In [1]:
# Parameters
data_name = "Runx2"
task_idxs = "0-213,216-278"
homer_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_scans"
modisco_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_modisco2019"
overwrite = False
In [2]:
from matlas.reports import collect_motifDB_to_be_displayed, display_comparative_cell_types

load data from labcluster

Using TensorFlow backend.
2019-08-23 11:33:00,135 [WARNING] git-lfs not installed
In [3]:
homer_matches, modisco_matches = collect_motifDB_to_be_displayed(task_idxs, homer_root, modisco_root, 
                                                              overwrite=False)

TF-MoDISco is using the TensorFlow backend.
In [4]:
display_comparative_cell_types(data_name, homer_matches, modisco_matches)
Runx2: Motif: M01307_2.00



Forward PWM

Reverse PWM

Shared Cell types both TF-MoDISco and Homer finds Runx2: #65

Cell typeModiscoHomer
MPP;A;CL

Pattern: metacluster_1/pattern_9

Significance: 0.0224617

/

Pattern: metacluster_1/pattern_22

Significance: 0.052698

Pattern: motif3.motif

Significance: 0.015511600000000002

T_MLD;TCR_SV40-I_CD8+;D35;A;GEO

Pattern: metacluster_1/pattern_4

Significance: 0.00363698

Pattern: motif4.motif

Significance: 0.00396302

T_MLD;TCR_SV40-I_CD8+;D28;A;GEO

Pattern: metacluster_1/pattern_8

Significance: 0.0107007

Pattern: motif4.motif

Significance: 5.5379899999999995e-05

memT_tmrD_lstr;TCR_SV40-I_CD8+;D7;A;GEO

Pattern: metacluster_1/pattern_6

Significance: 0.00931089

Pattern: motif4.motif

Significance: 0.0141674

memT_tmrD_lstr;TCR_SV40-I_CD8+;D14;A;GEO

Pattern: metacluster_0/pattern_5

Significance: 0.00424621

Pattern: motif4.motif

Significance: 0.0076295

memT_tmrD_lstr;TCR_SV40-I_CD8+;D35;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.0175388

Pattern: motif4.motif

Significance: 0.0136685

memT_tmrD;TCR_SV40-I_CD8+;D7;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.00637389

Pattern: motif4.motif

Significance: 0.00298351

iNKT;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.014427700000000002

Pattern: motif4.motif

Significance: 0.05289169999999999

Spleen;8wks;D;En

Pattern: metacluster_1/pattern_12

Significance: 0.0119027

Pattern: motif16.motif

Significance: 0.0156099

3134_mammaryADNCRCNM;D;En

Pattern: metacluster_0/pattern_7

Significance: 0.00757831

Pattern: motif5.motif

Significance: 0.00566108

B;B220_CD43;A;GEO

Pattern: metacluster_1/pattern_10

Significance: 0.00873835

Pattern: motif5.motif

Significance: 0.0335764

aB_LPS+IL4;A;CL

Pattern: metacluster_1/pattern_15

Significance: 0.0121305

Pattern: motif16.motif

Significance: 0.0355727

MCRPHG_BMD.UnStmltd;A;GEO

Pattern: metacluster_1/pattern_12

Significance: 0.00546665

Pattern: motif10.motif

Significance: 0.0552149

aB_LSP+a_d_dextran;A;CL

Pattern: metacluster_0/pattern_14

Significance: 0.00893544

Pattern: motif12.motif

Significance: 0.0400825

MCRPHG_BMD.LPD_Stmltd;A;GEO

Pattern: metacluster_1/pattern_15

Significance: 0.0167793

Pattern: motif13.motif

Significance: 0.00569056

Mast;A;CL

Pattern: metacluster_0/pattern_5

Significance: 0.0131106

Pattern: motif7.motif

Significance: 0.0161083

BSPHL;A;CL

Pattern: metacluster_1/pattern_6

Significance: 0.00976578

Pattern: motif4.motif

Significance: 0.012375299999999999

ESNPHL_ex-vivo_BlbC;A;CL

Pattern: metacluster_0/pattern_11

Significance: 0.016949000000000002

Pattern: motif11.motif

Significance: 0.050243699999999995

DC_LPS;2h;A;GEO

Pattern: metacluster_1/pattern_10

Significance: 0.0130873

Pattern: motif8.motif

Significance: 0.00381851

DC_pBMD;A;GEO

Pattern: metacluster_1/pattern_13

Significance: 3.42816e-06

Pattern: motif7.motif

Significance: 0.0127912

MEL_Znc_di-cl;24h;D;En

Pattern: metacluster_1/pattern_25

Significance: 0.00659386

Pattern: motif9.motif

Significance: 0.029540300000000002

3T3-L1;D;En

Pattern: metacluster_1/pattern_10

Significance: 0.05168330000000001

Pattern: motif6.motif

Significance: 0.00116278

CD4+CD8intTCR+CD69+CD24+;B2defM;A;CL

Pattern: metacluster_1/pattern_10

Significance: 0.0115192

Pattern: motif11.motif

Significance: 0.0501111

CD4+CD8-TCR+CD25+Foxp3-;A;CL

Pattern: metacluster_1/pattern_12

Significance: 0.011014399999999999

Pattern: motif14.motif

Significance: 0.00245048

DC_BMD;A;CL

Pattern: metacluster_1/pattern_8

Significance: 0.0107788

Pattern: motif6.motif

Significance: 0.0403397

DP3a;A;CL

Pattern: metacluster_1/pattern_3

Significance: 0.0132067

Pattern: motif3.motif

Significance: 0.0196779

DP3b;A;CL

Pattern: metacluster_1/pattern_4

Significance: 0.023250999999999997

Pattern: motif4.motif

Significance: 0.0418237

ES;MEF;A;CL

Pattern: metacluster_1/pattern_9

Significance: 0.012663500000000001

Pattern: motif6.motif

Significance: 0.00146533

pCMP;A;CL

Pattern: metacluster_1/pattern_3

Significance: 0.0118534

Pattern: motif4.motif

Significance: 0.017405900000000002

DC_LPS;4h;A;En

Pattern: metacluster_1/pattern_11

Significance: 0.00989833

Pattern: motif9.motif

Significance: 0.024431099999999997

pGMP;A;En

Pattern: metacluster_1/pattern_13

Significance: 0.028082799999999998

/

Pattern: metacluster_1/pattern_17

Significance: 0.00759933

Pattern: motif5.motif

Significance: 0.023856799999999997

DC;A;En

Pattern: metacluster_1/pattern_8

Significance: 0.007424299999999999

Pattern: motif7.motif

Significance: 0.00475546

NIH3T3_FBROBLST;D;GEO

Pattern: metacluster_1/pattern_14

Significance: 0.036200699999999995

Pattern: motif16.motif

Significance: 0.0280217

aB;CD180;A;CL

Pattern: metacluster_1/pattern_13

Significance: 4.54314e-05

Pattern: motif11.motif

Significance: 0.044437199999999996

LNG_TRM_HSC;A;CL

Pattern: metacluster_1/pattern_8

Significance: 0.00680275

Pattern: motif12.motif

Significance: 0.0470027

3134_mammaryADNCRCNM;D;GE

Pattern: metacluster_1/pattern_12

Significance: 0.0117068

Pattern: motif5.motif

Significance: 0.00224396

NK;IL2+IL12+;A;CL

Pattern: metacluster_1/pattern_7

Significance: 0.00685877

Pattern: motif3.motif

Significance: 0.00977623

apCD4Eff;D;GEO

Pattern: metacluster_1/pattern_6

Significance: 0.0078529

Pattern: motif4.motif

Significance: 0.00510904

NCR+ILC3;A;CL

Pattern: metacluster_1/pattern_3

Significance: 0.00591508

Pattern: motif3.motif

Significance: 0.0234689

416B_MP;CD34+;D;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.00960481

Pattern: motif4.motif

Significance: 0.0151651

NCR+ILC3+IL23;A;CL

Pattern: metacluster_1/pattern_4

Significance: 0.00343007

Pattern: motif5.motif

Significance: 0.00919906

CH12_QNTPLE;A;CL

Pattern: metacluster_1/pattern_13

Significance: 0.0160907

Pattern: motif18.motif

Significance: 0.0103172

wCH12;A;CL

Pattern: metacluster_1/pattern_17

Significance: 0.00778163

Pattern: motif15.motif

Significance: 0.00114637

FBRBLST;8wks;D;En

Pattern: metacluster_1/pattern_9

Significance: 0.0116236

Pattern: motif5.motif

Significance: 0.000542354

3T3-L1;FBRBLST;D;En

Pattern: metacluster_1/pattern_12

Significance: 0.0462852

Pattern: motif11.motif

Significance: 0.031764099999999997

CLP;A;CL

Pattern: metacluster_1/pattern_4

Significance: 0.024542599999999998

Pattern: motif3.motif

Significance: 0.00431526

mem_precrsrT_SPLND;CD8+;A;GEO

Pattern: metacluster_1/pattern_3

Significance: 0.00315615

Pattern: motif4.motif

Significance: 0.00358067

NK_LVRD;CD19-CD3e-NKp46+DX+Trail-;A;GEO

Pattern: metacluster_1/pattern_4

Significance: 0.00589335

Pattern: motif3.motif

Significance: 0.0571386

ILC2+IL33+IL25;A;GEO

Pattern: metacluster_1/pattern_7

Significance: 0.00545524

Pattern: motif5.motif

Significance: 0.0299788

ILC1;A;GEO

Pattern: metacluster_1/pattern_3

Significance: 0.010506399999999999

Pattern: motif4.motif

Significance: 0.00183818

ILC3;A;GEO

Pattern: metacluster_1/pattern_3

Significance: 0.00691599

Pattern: motif3.motif

Significance: 0.00301741

ILC1_AbxGRMFree;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.00912942

Pattern: motif4.motif

Significance: 0.028374700000000003

ILC2_AbxGRMFree;A;GEO

Pattern: metacluster_1/pattern_15

Significance: 0.0101309

Pattern: motif9.motif

Significance: 0.0115041

ILC3_AbxGRMFree;A;GEO

Pattern: metacluster_1/pattern_3

Significance: 0.00663653

Pattern: motif3.motif

Significance: 0.028639799999999997

T_LCMV;CD8+;D8;A;GEO

Pattern: metacluster_1/pattern_6

Significance: 0.00700785

Pattern: motif4.motif

Significance: 0.0105515

T_LCMV;CD8+;D33;A;GEO

Pattern: metacluster_1/pattern_4

Significance: 0.00965361

Pattern: motif4.motif

Significance: 0.0524038

T_LCMV;CD8+;D35;A;GEO

Pattern: metacluster_1/pattern_4

Significance: 0.0069123000000000006

Pattern: motif4.motif

Significance: 0.059033100000000005

Muller;P12;D;En

Pattern: metacluster_1/pattern_10

Significance: 0.0121198

Pattern: motif5.motif

Significance: 0.0266765

TExh_SPLND;CD8+;A;GEO

Pattern: metacluster_1/pattern_8

Significance: 0.0126227

Pattern: motif4.motif

Significance: 0.0177288

TSLEC_SPLND;CD8+A;GEO

Pattern: metacluster_1/pattern_8

Significance: 0.00386993

Pattern: motif4.motif

Significance: 0.0211646

cntrl_memT;TCR_SV40-I_CD8+;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.0136213

Pattern: motif4.motif

Significance: 0.023668099999999997

T_MLD;TCR_SV40-I_CD8+;D5;A;GEO

Pattern: metacluster_1/pattern_11

Significance: 0.0107158

Pattern: motif9.motif

Significance: 0.031104400000000004

T_MLD;TCR_SV40-I_CD8+;D7;A;GEO

Pattern: metacluster_1/pattern_4

Significance: 0.00582652

Pattern: motif4.motif

Significance: 0.0431049

T_MLD;TCR_SV40-I_CD8+;D14;A;GEO

Pattern: metacluster_1/pattern_4

Significance: 0.00522715

Pattern: motif4.motif

Significance: 0.0594582

T_MLD;TCR_SV40-I_CD8+;D21;A;GEO

Pattern: metacluster_1/pattern_6

Significance: 0.00909769

Pattern: motif5.motif

Significance: 0.010035299999999999

Unique Cell types only TF-MoDISco finds Runx2: #67

Cell typeModiscoHomer
naiveCD8;A;CL

Pattern: metacluster_0/pattern_7

Significance: 0.00647218

Absent
memT;CD4+;A;CL

Pattern: metacluster_1/pattern_10

Significance: 0.00763416

Absent
Th17;CD4+;A;CL

Pattern: metacluster_1/pattern_8

Significance: 0.011629200000000001

Absent
NK_SPLND;A;CL

Pattern: metacluster_0/pattern_5

Significance: 0.00624624

Absent
proB;A;CL

Pattern: metacluster_1/pattern_7

Significance: 0.0118791

Absent
preB;A;CL

Pattern: metacluster_1/pattern_16

Significance: 0.00101306

Absent
T_MLD;TCR_SV40-I_CD8+;D60;A;GEO

Pattern: metacluster_0/pattern_4

Significance: 0.00968651

Absent
matureB;A;CL

Pattern: metacluster_0/pattern_11

Significance: 0.00121772

Absent
MZ_B;A;CL

Pattern: metacluster_1/pattern_10

Significance: 0.0066471

Absent
B1_B;A;CL

Pattern: metacluster_1/pattern_16

Significance: 0.00341127

Absent
memT_tmrD;TCR_SV40-I_CD8+;D14;A;GEO

Pattern: metacluster_1/pattern_9

Significance: 0.00775405

Absent
plasmaB;A;CL

Pattern: metacluster_1/pattern_19

Significance: 0.00114631

Absent
aB;A;GEO

Pattern: metacluster_1/pattern_15

Significance: 0.00355805

Absent
preB_BMD;A;GEO

Pattern: metacluster_1/pattern_15

Significance: 0.0164182

Absent
AML;D;En

Pattern: metacluster_1/pattern_8

Significance: 0.00533243

Absent
AML;AE9a;A;GEO

Pattern: metacluster_1/pattern_7

Significance: 0.0135608

Absent
DC_LPS;6h;A;GEO

Pattern: metacluster_1/pattern_13

Significance: 0.00698642

/

Pattern: metacluster_1/pattern_21

Significance: 0.011915899999999998

/

Pattern: metacluster_1/pattern_22

Significance: 7.248639999999999e-06

Absent
MEL;D;En

Pattern: metacluster_1/pattern_12

Significance: 0.0159546

Absent
Tfh_LCMV;A;CL

Pattern: metacluster_1/pattern_9

Significance: 0.0102417

Absent
Tfh;A;CL

Pattern: metacluster_1/pattern_13

Significance: 0.00326714

Absent
aNonTfh;A;CL

Pattern: metacluster_1/pattern_6

Significance: 0.010081399999999999

Absent
aNonTfh_mut;A;CL

Pattern: metacluster_1/pattern_11

Significance: 0.0105479

Absent
Tfr;CD4+CD44+CXCR5+PD1+CD25+;A;CL

Pattern: metacluster_1/pattern_14

Significance: 0.00595939

Absent
Tfr_mut;CD4+CD44+CXCR5+PD1+CD25+;A;CL

Pattern: metacluster_1/pattern_15

Significance: 0.018306799999999998

Absent
naiveT;CD4+_CD44-_CD62L-_CD25-;A;CL

Pattern: metacluster_1/pattern_6

Significance: 0.0341161

Absent
naiveT_mut;CD4+_CD44-_CD62L-_CD25-;A;CL

Pattern: metacluster_1/pattern_13

Significance: 0.00121176

Absent
largeDPprecrsr;CD4+CD8+CD69-;A;CL

Pattern: metacluster_1/pattern_14

Significance: 0.010580899999999999

Absent
smallDPprecrsor;CD4+CD8+CD69-;A;CL

Pattern: metacluster_1/pattern_13

Significance: 0.00937593

Absent
wES;FaceP;E14.5;D;En

Pattern: metacluster_0/pattern_21

Significance: 0.012561200000000002

Absent
CD4+CD8-TCR+CD69+CD24+CD25-;B2defM;A;CL

Pattern: metacluster_1/pattern_11

Significance: 0.010936

Absent
CD4+CD8-TCR+CD69-CD24-CD25-;B2defM;A;CL

Pattern: metacluster_1/pattern_6

Significance: 0.00871647

Absent
CD4+CD8intTCR+CD69+CD24+;MHC2defM;A;CL

Pattern: metacluster_1/pattern_9

Significance: 0.029739299999999996

Absent
CD4+CD8+TCR+CD69+CD24+;MHC2defM;A;C

Pattern: metacluster_1/pattern_10

Significance: 0.00435064

Absent
CD4+CD8+TCR+CD69-CD24-;MHC2defM;A;CL

Pattern: metacluster_1/pattern_6

Significance: 0.0256829

Absent
BCK_SKN;A;GEO

Pattern: metacluster_0/pattern_17

Significance: 0.00216522

Absent
CD4+CD8-TCR+CD25-Foxp3+;A;CL

Pattern: metacluster_1/pattern_9

Significance: 0.012765

Absent
CD4+CD8-TCR+CD25+Foxp3+;A;CL

Pattern: metacluster_1/pattern_12

Significance: 0.017004

Absent
MCRPHG;A;CL

Pattern: metacluster_1/pattern_17

Significance: 0.0278893

/

Pattern: metacluster_1/pattern_18

Significance: 0.00158821

Absent
DP;A;CL

Pattern: metacluster_1/pattern_11

Significance: 0.0161229

Absent
ISP;A;CL

Pattern: metacluster_1/pattern_11

Significance: 0.00664038

Absent
ThMS_MEC;Aire++;A;GEO

Pattern: metacluster_1/pattern_20

Significance: 0.046588199999999996

Absent
Mammary_BptfKO;A;GEO

Pattern: metacluster_0/pattern_25

Significance: 0.00297967

Absent
pMeg;A;En

Pattern: metacluster_1/pattern_13

Significance: 0.0181754

/

Pattern: metacluster_1/pattern_19

Significance: 0.00553012

Absent
MegP;A;En

Pattern: metacluster_1/pattern_10

Significance: 0.00921353

Absent
LNG;8wks;D;GEO

Pattern: metacluster_0/pattern_23

Significance: 0.0110204

Absent
SHRT_TRM_HSC;A;CL

Pattern: metacluster_1/pattern_8

Significance: 0.00921048

Absent
gamma_delta_TCR;A;CL

Pattern: metacluster_1/pattern_8

Significance: 0.00922397

Absent
gamma_delta_TCR_MCR;A;CL

Pattern: metacluster_1/pattern_12

Significance: 0.012804300000000001

Absent
gamma_delta_TCR_M-S-;A;CL

Pattern: metacluster_0/pattern_8

Significance: 0.00649926

Absent
naiveT_SPLND;CD4+;D;GEO

Pattern: metacluster_1/pattern_9

Significance: 0.0410774

Absent
ILC2precrsr;A;CL

Pattern: metacluster_1/pattern_12

Significance: 0.04063169999999999

Absent
ILC2_Nippo;A;CL

Pattern: metacluster_1/pattern_8

Significance: 0.0483978

Absent
ILC1;A;CL

Pattern: metacluster_1/pattern_4

Significance: 0.00705195

Absent
ILC2;A;CL

Pattern: metacluster_1/pattern_9

Significance: 0.0316859

Absent
Th2_nippo;A;CL

Pattern: metacluster_1/pattern_12

Significance: 0.00979585

Absent
aB_LPS+IL4_24h;A;CL

Pattern: metacluster_0/pattern_17

Significance: 0.00612792

Absent
aB_LPS+IL4+Oligomycin_24h;A;CL

Pattern: metacluster_1/pattern_20

Significance: 0.0409913

Absent
NIH3T3_FBROBLST;D;En

Pattern: metacluster_1/pattern_15

Significance: 0.0291051

Absent
wCH12_drug;A;CL

Pattern: metacluster_1/pattern_19

Significance: 0.00548895

Absent
Mammary_GLND;A;GEO

Pattern: metacluster_1/pattern_20

Significance: 9.69963e-05

Absent
ILC2;A;GEO

Pattern: metacluster_1/pattern_9

Significance: 0.0113432

Absent
abTreg;CD4+_CD25+;8wks;D;En

Pattern: metacluster_1/pattern_6

Significance: 0.027420299999999998

Absent
naiveT;CD8+;A;GEO

Pattern: metacluster_1/pattern_7

Significance: 0.0191067

Absent
416B_MP;CD34+;D;En

Pattern: metacluster_1/pattern_5

Significance: 0.00789126

Absent
TEff_SPLND;CD8+;A;GEO

Pattern: metacluster_1/pattern_6

Significance: 0.00782392

Absent
naiveT;trnsgncTCR_SV40-I_CD8;A;GEO

Pattern: metacluster_0/pattern_6

Significance: 0.0301181

Absent
Teff;TCR_SV40-I_CD8+;D7;A;GEO

Pattern: metacluster_1/pattern_6

Significance: 0.019530099999999998

Absent
Unique Cell types only Homer finds Runx2: #5

Cell typeModiscoHomer
restingB;A;CLAbsent

Pattern: motif17.motif

Significance: 0.030088999999999998

prePLSM_B;A;GEOAbsent

Pattern: motif15.motif

Significance: 0.0542031

416B;HMTP_SPNSN;CD34+;D;EnAbsent

Pattern: motif4.motif

Significance: 0.0347445

T_SPLND_blstCLTRD;CD4+;D;GEOAbsent

Pattern: motif4.motif

Significance: 0.05164

MegEP;A;CLAbsent

Pattern: motif12.motif

Significance: 0.0410968