In [1]:
# Parameters
data_name = "Tcf7l1"
task_idxs = "0-213,216-278"
homer_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_scans"
modisco_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_modisco2019"
overwrite = False
In [2]:
from matlas.reports import collect_motifDB_to_be_displayed, display_comparative_cell_types

load data from labcluster

Using TensorFlow backend.
2019-08-23 11:42:41,384 [WARNING] git-lfs not installed
In [3]:
homer_matches, modisco_matches = collect_motifDB_to_be_displayed(task_idxs, homer_root, modisco_root, 
                                                              overwrite=False)

TF-MoDISco is using the TensorFlow backend.
In [4]:
display_comparative_cell_types(data_name, homer_matches, modisco_matches)
Tcf7l1: Motif: M00207_2.00



Forward PWM

Reverse PWM

Shared Cell types both TF-MoDISco and Homer finds Tcf7l1: #21

Cell typeModiscoHomer
wES;NRL_Tube;E11.5;D;En

Pattern: metacluster_1/pattern_5

Significance: 0.0202246

Pattern: motif15.motif

Significance: 0.0253569

SKLTL_Muscle;8wks;D;En

Pattern: metacluster_1/pattern_12

Significance: 0.00987101

Pattern: motif10.motif

Significance: 0.013095500000000001

prePLSM_B;A;GEO

Pattern: metacluster_1/pattern_20

Significance: 0.040053500000000006

Pattern: motif22.motif

Significance: 0.017396099999999998

plasmaB;A;CL

Pattern: metacluster_1/pattern_5

Significance: 0.000278971

Pattern: motif9.motif

Significance: 0.0241587

preB_BMD;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.00020360900000000002

Pattern: motif9.motif

Significance: 0.00789882

B;B220_CD43;A;GEO

Pattern: metacluster_1/pattern_9

Significance: 0.00020817

Pattern: motif11.motif

Significance: 0.0268827

largeDPprecrsr;CD4+CD8+CD69-;A;CL

Pattern: metacluster_1/pattern_5

Significance: 0.00569669

/

Pattern: metacluster_1/pattern_17

Significance: 8.784629999999999e-05

Pattern: motif18.motif

Significance: 0.027719099999999997

smallDPprecrsor;CD4+CD8+CD69-;A;CL

Pattern: metacluster_1/pattern_4

Significance: 0.00425152

/

Pattern: metacluster_1/pattern_15

Significance: 0.0005052769999999999

/

Pattern: metacluster_1/pattern_16

Significance: 0.0510645

Pattern: motif13.motif

Significance: 0.026623599999999997

CD4+CD8-TCR+CD69-CD24-CD25-;B2defM;A;CL

Pattern: metacluster_1/pattern_11

Significance: 0.000713926

Pattern: motif17.motif

Significance: 0.026615100000000003

NPC;F129;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.013948400000000001

Pattern: motif10.motif

Significance: 0.014336700000000003

NPC;G4;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.00272578

Pattern: motif9.motif

Significance: 0.00707352

NPC;Ch13;A;GEO

Pattern: metacluster_1/pattern_9

Significance: 0.00630504

Pattern: motif13.motif

Significance: 0.00672427

NPC;mE6;A;GEO

Pattern: metacluster_1/pattern_7

Significance: 0.00265161

Pattern: motif11.motif

Significance: 0.00547962

DP;A;CL

Pattern: metacluster_1/pattern_10

Significance: 0.00804504

Pattern: motif17.motif

Significance: 0.0232814

iPV_NRN;A;GEO

Pattern: metacluster_1/pattern_3

Significance: 0.000106758

Pattern: motif3.motif

Significance: 0.0128835

DP3b;A;CL

Pattern: metacluster_1/pattern_3

Significance: 0.0108498

/

Pattern: metacluster_1/pattern_8

Significance: 0.000142318

Pattern: motif7.motif

Significance: 0.0265288

ISP;A;CL

Pattern: metacluster_1/pattern_4

Significance: 0.0006918889999999999

/

Pattern: metacluster_1/pattern_15

Significance: 0.000316859

Pattern: motif14.motif

Significance: 0.0155834

/

Pattern: motif19.motif

Significance: 0.054122300000000005

ES;E14;A;CL

Pattern: metacluster_1/pattern_10

Significance: 8.378059999999999e-05

Pattern: motif7.motif

Significance: 0.0582135

Muscle;A;CL

Pattern: metacluster_1/pattern_16

Significance: 0.0246981

Pattern: motif19.motif

Significance: 0.025906400000000003

RTN;D1;D;En

Pattern: metacluster_0/pattern_4

Significance: 0.028844400000000003

Pattern: motif16.motif

Significance: 0.030653700000000002

wES;Md_BRN;E11.5;D;En

Pattern: metacluster_0/pattern_4

Significance: 0.00829859

Pattern: motif19.motif

Significance: 0.0333715

Unique Cell types only TF-MoDISco finds Tcf7l1: #50

Cell typeModiscoHomer
naiveCD8;A;CL

Pattern: metacluster_0/pattern_13

Significance: 0.0009343110000000001

Absent
memT;CD4+;A;CL

Pattern: metacluster_1/pattern_13

Significance: 0.00047125300000000004

Absent
wES;Fr_lmb;E11.5;D;En

Pattern: metacluster_1/pattern_3

Significance: 0.0236767

Absent
wES;limb;E11.5;D;En

Pattern: metacluster_0/pattern_6

Significance: 0.00770948

/

Pattern: metacluster_0/pattern_16

Significance: 0.00026576299999999997

Absent
proB;A;CL

Pattern: metacluster_1/pattern_3

Significance: 0.000355754

Absent
preB;A;CL

Pattern: metacluster_1/pattern_4

Significance: 0.00149735

Absent
wES;Hnd_lmb;E11.5;D;En

Pattern: metacluster_0/pattern_15

Significance: 0.000276933

/

Pattern: metacluster_0/pattern_22

Significance: 0.0495245

Absent
iNKT;A;GEO

Pattern: metacluster_1/pattern_17

Significance: 0.034719599999999996

Absent
Tfh_LCMV;A;CL

Pattern: metacluster_1/pattern_16

Significance: 0.0410156

/

Pattern: metacluster_1/pattern_18

Significance: 0.000225364

Absent
aNonTfh;A;CL

Pattern: metacluster_1/pattern_18

Significance: 0.0017858000000000001

Absent
wES;3rd_Rhmbmr;E8.5;A;GEO

Pattern: metacluster_0/pattern_10

Significance: 0.0006454519999999999

Absent
npES;5th_Rhmbmr_delC;E8.5;A;GEO

Pattern: metacluster_1/pattern_21

Significance: 0.012377899999999999

Absent
wES;5th_Rhmbmr;E9.5;A;GEO

Pattern: metacluster_0/pattern_15

Significance: 0.013943500000000001

Absent
wES;5th_Rhmbmr;E8.5;A;GEO

Pattern: metacluster_0/pattern_12

Significance: 0.00271457

Absent
npES;5th_Rhmbmr_delA;E8.5;A;GEO

Pattern: metacluster_0/pattern_5

Significance: 0.0452741

Absent
CD4+CD8intTCR+CD69+CD24+;B2defM;A;CL

Pattern: metacluster_1/pattern_13

Significance: 0.0162666

/

Pattern: metacluster_1/pattern_14

Significance: 0.020815200000000002

Absent
CD4+CD8-TCR+CD69+CD24+CD25-;B2defM;A;CL

Pattern: metacluster_1/pattern_12

Significance: 0.00115337

Absent
naiveT;CD4+_CD44-_CD62L-_CD25-;A;CL

Pattern: metacluster_1/pattern_12

Significance: 0.000149696

Absent
naiveT_mut;CD4+_CD44-_CD62L-_CD25-;A;CL

Pattern: metacluster_1/pattern_15

Significance: 0.014282

Absent
wES;posterior;1;E9.5;A;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.00765077

Absent
wES;posterior;2;E9.5;A;GEO

Pattern: metacluster_0/pattern_9

Significance: 0.0108043

Absent
CD4+CD8-TCR+CD25+Foxp3-;A;CL

Pattern: metacluster_1/pattern_10

Significance: 0.000104381

Absent
CD4+CD8-TCR+CD25-Foxp3+;A;CL

Pattern: metacluster_1/pattern_16

Significance: 0.000149622

Absent
wES;posterior;1;E8.5;A;GEO

Pattern: metacluster_0/pattern_3

Significance: 0.0593254

/

Pattern: metacluster_0/pattern_10

Significance: 0.00139833

Absent
npES;posterior_delC;E8.5;A;GEO

Pattern: metacluster_0/pattern_9

Significance: 0.00292596

Absent
npES;posterior_delA;E8.5;A;GEO

Pattern: metacluster_0/pattern_3

Significance: 0.0286314

/

Pattern: metacluster_0/pattern_8

Significance: 0.0222329

Absent
BCK_SKN;A;GEO

Pattern: metacluster_0/pattern_22

Significance: 0.00163442

/

Pattern: metacluster_0/pattern_23

Significance: 0.0291849

Absent
wES.CRNL_NRL_CRST;E10.5;A;GEO

Pattern: metacluster_0/pattern_18

Significance: 0.00284761

Absent
iVIP_NRN;A;GEO

Pattern: metacluster_1/pattern_0

Significance: 0.0192233

/

Pattern: metacluster_1/pattern_18

Significance: 0.0195924

Absent
Corticotrope;A;GEO

Pattern: metacluster_0/pattern_17

Significance: 0.010353200000000002

Absent
LNG;A;CL

Pattern: metacluster_1/pattern_20

Significance: 0.00519967

Absent
Melanotrope;A;GEO

Pattern: metacluster_0/pattern_8

Significance: 0.0137314

Absent
ES;JM8.N4;Asynch;A;GEO

Pattern: metacluster_0/pattern_10

Significance: 0.050375199999999995

Absent
BRN;OLFTRY_BLB;A;CL

Pattern: metacluster_0/pattern_13

Significance: 0.00225171

Absent
ES;ZhBTc4;2;D;GEO

Pattern: metacluster_1/pattern_5

Significance: 0.0286096

Absent
gamma_delta_TCR;A;CL

Pattern: metacluster_1/pattern_21

Significance: 0.019056

Absent
apCD4Eff;D;GEO

Pattern: metacluster_1/pattern_17

Significance: 0.00027949

Absent
WHL_BRN;8wks;D;GEO

Pattern: metacluster_1/pattern_10

Significance: 0.00875166

Absent
wCH12_drug;A;CL

Pattern: metacluster_1/pattern_17

Significance: 0.00329604

Absent
ES;J1;A;CL

Pattern: metacluster_1/pattern_4

Significance: 0.044213199999999994

Absent
LNG;8wks;D;En

Pattern: metacluster_0/pattern_17

Significance: 0.0477549

Absent
ES;F1216;A;GEO

Pattern: metacluster_0/pattern_7

Significance: 0.0594091

Absent
Heart;8wks;D;En

Pattern: metacluster_0/pattern_11

Significance: 0.0195195

Absent
wES;RTN;E11.5;D;En

Pattern: metacluster_0/pattern_3

Significance: 0.042715699999999995

Absent
Fr_BRN;P0;D;En

Pattern: metacluster_1/pattern_15

Significance: 0.0347755

Absent
wES;Hnd_BRN;E11.5;D;En

Pattern: metacluster_0/pattern_4

Significance: 0.0036404000000000002

Absent
wES;Hnd_BRN;E14.5;D;En

Pattern: metacluster_0/pattern_7

Significance: 0.0243736

Absent
wES;Md_BRN;E14.4;D;En

Pattern: metacluster_0/pattern_4

Significance: 0.00718998

Absent
wES;WHL_BRN;E14.5;D;En

Pattern: metacluster_1/pattern_3

Significance: 0.0165819

/

Pattern: metacluster_1/pattern_5

Significance: 0.014547999999999998

Absent
WHL_BRN;8wks;D;En

Pattern: metacluster_1/pattern_11

Significance: 0.0240327

Absent
Unique Cell types only Homer finds Tcf7l1: #9

Cell typeModiscoHomer
wES;limb;E14.5;D;EnAbsent

Pattern: motif5.motif

Significance: 0.0151236

wES;FaceP;E14.5;D;EnAbsent

Pattern: motif5.motif

Significance: 0.008357700000000001

LNG;P0;D;EnAbsent

Pattern: motif18.motif

Significance: 0.027951900000000002

wES;LNG;E14.5;D;EnAbsent

Pattern: motif13.motif

Significance: 0.016567500000000002

CD4+CD8+TCR+CD69-CD24-;MHC2defM;A;CLAbsent

Pattern: motif14.motif

Significance: 0.040205

A20;B-lymphoma;D;EnAbsent

Pattern: motif13.motif

Significance: 0.014824500000000001

DP3a;A;CLAbsent

Pattern: motif12.motif

Significance: 0.00484764

wES;MSDRM;E11.5;D;EnAbsent

Pattern: motif4.motif

Significance: 0.00820756

Heart;D;EnAbsent

Pattern: motif13.motif

Significance: 0.00718985