o
    ïØàf`2  ã                   @   s  d dl Z d dlZd dlZd dlZd dlZd dlmZ	 d dl
mZ d dlmZ d dlmZ d dlmZ d dlmZ d dlmZ dd	lmZ d
d„ Zdd„ Zdd„ Zdd„ Zdd„ Zdd„ ZG dd„ deƒZd(dd„ZdZ dddddœZ!ed d!Z"e e!e"fd"d#„Z#d$d%„ Z$d&d'„ Z%dS ))é    N)ÚAbstractPathEffect)ÚTextPath)ÚAffine2D)ÚFontProperties)Úpatches)ÚTemplateé   )Ú	templatesc                 C   sD   |   d¡\}}|dkrd}n|dkrd}|  d¡d }|› d|› S )	NÚ.Úpos_patternsú+Úneg_patternsú-Ú_r   ú/)Úsplit)ÚnameÚgroupZmotifZgroup_shortZ	motif_num© r   ú>/users/shouvikm/ChromBPNet/finemo_gpu/src/finemo/evaluation.pyÚabbreviate_motif_name   s   r   c           
      C   s¢   |   ¡ jddddd d¡jtj|Ž d dg¡}|j}t|ƒ}t	j
||ft	jd}t|ƒD ]\}}| |¡ ¡ |d d …|f< q.|dk t	j¡}|j| }	||	fS )	NÚpeak_idÚ
motif_nameÚcountÚsum)ÚindexÚcolumnsÚvaluesÚaggregate_functionr   )Útotal©Údtype)ÚcollectÚpivotÚ	fill_nullÚwith_columnsÚplÚsum_horizontalÚsortÚheightÚlenÚnpÚzerosÚint16Ú	enumerateÚ
get_columnÚto_numpyÚastypeÚint32ÚT)
Úhits_dfÚmotif_namesÚocc_dfÚ	num_peaksÚ
num_motifsZocc_matÚiÚmZocc_binZcooccr   r   r   Úget_motif_occurences   s"   
þ
üú	
r;   c                 C   sd  t j |d¡}t j|dd |D ]M}tjdd\}}tj|  |¡dd\}}|| 	¡  }	t 
|¡d }
t |
¡}t |
¡}|	||< | ||¡ t j ||› d¡}tj|d	d
 t |¡ qtjdd\}}tj|  d¡dd\}}|| 	¡  }	t 
|¡d }
t |
¡}t |
¡}|	||< | ||¡ | d¡ | d¡ t j |d¡}tj|d	d
 t |¡ d S )NZmotif_hit_distributionsT©Úexist_ok)é   é   ©Úfigsize)Úreturn_countsr   ú.pngé,  ©Zdpi)é   é   r   zMotifs per peakZ	Frequencyztotal_hit_distribution.png)ÚosÚpathÚjoinÚmakedirsÚpltÚsubplotsr+   Úuniquer/   r   ÚamaxÚaranger,   ÚbarÚsavefigÚcloseÚ
set_xlabelÚ
set_ylabel)r6   r5   Úplot_dirZ
motifs_dirr:   ÚfigÚaxrN   ÚcountsÚfreqZnum_binsÚxÚyÚoutput_pathr   r   r   Úplot_hit_distributions6   s6   





r^   c                 C   sÖ   dt  t  | ¡¡ }| |dd…df  |ddd…f  }dd„ |D ƒ}tjdd\}}|j|ddd	d
 | t  t|ƒ¡¡ | 	|¡ | 
t  t|ƒ¡¡ |j|dd | d¡ | d¡ tj|dd t ¡  dS )zF
    Plots a simple indicator heatmap of the motifs in each peak.
    r   Nc                 S   s   g | ]}t |ƒ‘qS r   )r   )Ú.0r:   r   r   r   Ú
<listcomp>c   s    z5plot_peak_motif_indicator_heatmap.<locals>.<listcomp>©rF   rF   r@   ÚnearestÚautoZGreens)ÚinterpolationZaspectZcmapéZ   )ZrotationzMotif izMotif jrD   rE   )r+   ÚsqrtÚdiagrL   rM   ÚimshowZ
set_yticksrP   r*   Zset_yticklabelsZ
set_xticksZset_xticklabelsrT   rU   rR   rS   )Zpeak_hit_countsr5   r]   Zcov_normÚmatrixZ
motif_keysrW   rX   r   r   r   Ú!plot_peak_motif_indicator_heatmap]   s   $


rj   c              	   C   sâ  |j t d¡t d¡t d¡ t d¡d}| d¡ ¡ }| d¡ ¡ }| d¡ ¡  t¡}|d d …d d f }|d d …d d f tjdd|ft	d	 }|| d d …d d …f  t 
|¡d d d d …f 7  < ||d d …d d …f  t 
|¡d d d d d
…f 7  < tj|jd ddft	d	}	|	| d d …d d …f  t 
d¡d d d …d f 7  < |	|d d …d d …f  t 
d¡d d d d
…d f 7  < | ||	|f }
t ¡  tjddd tjddd |
jdd}W d   ƒ |S 1 sêw   Y  |S )Nr   Ústart_untrimmedÚpeak_region_startÚ
is_revcomp)Úpeak_idxÚ	start_idxrm   rn   ro   r   r    éÿÿÿÿr   rG   Úignorez#invalid value encountered in divide)ÚactionÚmessagezMean of empty slice©Úaxis)Úselectr&   Úcolr/   r0   r1   Úboolr+   r,   ÚintrP   ÚshapeÚwarningsÚcatch_warningsÚfilterwarningsÚmean)ÚregionsZpositions_dfÚmotif_widthZidx_dfrn   ro   rm   Úrow_idxZpos_idxZnuc_idxZseqsÚcwmsr   r   r   Úget_cwmsw   s4   üÿ&4444

ýûrƒ   c           $   
   C   sî  |  t d¡ tj¡¡j| ¡ dddjt d¡t d¡t d¡t d¡dkt d	¡t d
¡t d¡d}|jg d¢d}| j	d }|d }	| 
t d¡t d
¡ |	| kt d¡t d
¡ |	| k@ ¡jg d¢d}
|
j|g d¢dd ¡ }|j|g d¢dd ¡ }|
j|g d¢dd ¡ }| ¡ jd	dd}|
 ¡ jd	dd}| ¡ jd	dd}|jd	dd}|jd	dd}|jd	dd}i }i }| ¡ }|D ]š}| ||¡}| ||¡}
| ||¡}| ||¡}| ||¡}| ||¡}t |j¡|j |j|
j|j|j|j|jdœ||< t| ||ƒt| ||ƒt| ||ƒt| ||ƒdœ||< || d d d d…d d d…f || d< || d }|| d }t |d  ¡ ¡}t |d  ¡ ¡} ||  ¡ ||   }!|!|| d< qÉdd„ | ¡ D ƒ}"t |"¡}#||#|fS )Nr   Úinner)ÚonÚhowÚchrrk   Úend_untrimmedÚstrandr   r   rl   )r‡   rk   rˆ   rm   r   rl   r   )r‡   rk   r   rm   )Úsubsetr?   )r‡   rk   rm   r   ÚantiT)Úas_dict)Úseqlet_recallÚnum_hits_totalZnum_hits_restrictedÚnum_seqletsZnum_overlapsZnum_seqlets_onlyZnum_hits_restricted_only)Úhits_fcÚ
seqlets_fcÚseqlets_onlyÚhits_restricted_onlyr   rp   Zhits_rcr“   r‘   Zcwm_correlationc                 S   s   g | ]
\}}d |i|B ‘qS )r   r   )r_   ÚkÚvr   r   r   r`   ü   s    z!seqlet_recall.<locals>.<listcomp>)r%   r&   rw   ÚcastÚUInt32rJ   Úlazyrv   rN   rz   Úfilterr"   Úpartition_byÚclearÚgetr+   Úfloat64r)   rƒ   rf   r   ÚitemsÚ
from_dicts)$r   r4   Úpeaks_dfÚ
seqlets_dfr5   Úmodisco_half_widthr€   Zhits_uniqueZ
region_lenÚcenterZhits_filteredZoverlaps_dfZseqlets_only_dfZhits_only_filtered_dfZhits_by_motifZhits_fitered_by_motifZseqlets_by_motifZoverlaps_by_motifZseqlets_only_by_motifZhits_only_filtered_by_motifÚrecall_datar‚   Zdummy_dfr:   ÚhitsZseqletsZoverlapsr’   Zhits_only_filteredZhits_only_cwmZseqlets_cwmZhnormZsnormZcwm_corÚrecordsÚ	recall_dfr   r   r   r   –   s®   
ýôÿ
ÿÿûÿ
ýú
ýú
ýú	
ù




ü(

r   c                       s*   e Zd Z		d‡ fdd„	Zdd„ Z‡  ZS )	Ú	LogoGlyphÚEN©ç        r«   c                    sÊ   t ƒ  |¡ td|d|d}| ¡ }td|d|d ¡ }d|j }	t|j|jƒ}
d|
 }d|j|
  d }|j }|j }t	ƒ j
||dj||	dj
|dd}tjg fi |¤Ž| _| |¡| j_|| _d S )N©r   r   r   )ÚsizeÚpropr?   )ZtxÚty)ZsxZsyr   )ÚsuperÚ__init__r   Zget_extentsr)   ÚmaxÚwidthÚx0Zy0r   Ú	translateÚscaler   Z	PathPatchÚpatchZtransform_pathÚ_pathZ_gc)ÚselfÚglyphZ	ref_glyphÚ
font_propsÚoffsetÚkwargsZ	path_origÚdimsZref_dimsZh_scaleZ	ref_widthZw_scaleZw_shiftZx_shiftZy_shiftZstretch©Ú	__class__r   r   r±     s*   
ÿþýÿ
zLogoGlyph.__init__c                 C   sj   | j j|d | j  ||  |¡ ¡ | j  | ¡ ¡ | ¡ }|r-| j  ¡ d u r-| j j|Ž  | j  |¡ d S )N)Úcolor)	r·   ÚsetZset_transformZ_offset_transformZset_clip_boxZget_clip_rectangleZget_clip_pathZset_clip_pathÚdraw)r¹   ZrendererÚgcZtpathZaffineZrgbFaceZ	clip_pathr   r   r   Ú	draw_path  s   zLogoGlyph.draw_path)r©   Nrª   )Ú__name__Ú
__module__Ú__qualname__r±   rÅ   Ú__classcell__r   r   r¿   r   r¨     s
    ÿr¨   c              
   C   sB  |d u rdd„ |D ƒ}| j ddd t |dd ¡}t |d d¡}tj|dd}tj|ddd d d…d d …f }tj|dd}	tj|dd}
tjtjtj||dddd|	dd}tjtjtj||dddd|
dd}|| | }t |jd ¡}t|||ƒD ]\}}}| j	||d|t
||d	g|| d
 q| jdddd d S )Nc                 S   s   i | ]}|d “qS )Nr   )r_   Úgr   r   r   Ú
<dictcomp>+  s    zplot_logo.<locals>.<dictcomp>r   )r[   r\   rt   rp   r   gffffffî?)r»   )ÚbottomZpath_effectsrÁ   g      à?Zblack)ZzorderÚ	linewidthrÁ   )Zmarginsr+   ÚclipÚargsortÚtake_along_axisÚcumsumrP   rz   ÚziprQ   r¨   Zaxhline)rX   ZheightsZglyphsÚcolorsr»   Z
pos_valuesZ
neg_valuesZ	pos_orderZ	neg_orderZpos_reorderZneg_reorderZpos_offsetsZneg_offsetsZbottomsr[   rº   r)   rÌ   r   r   r   Ú	plot_logo)  s8    ÿýÿýÿrÔ   ZACGTz#109648z#255C99z#F7B32Bz#D62839)ÚAÚCÚGr3   Úbold)Úweightc              	   C   s°   |   ¡ D ]Q\}}tj ||¡}tj|dd |  ¡ D ]:\}}	tj ||› d¡}
tjdd\}}t||	|||d |j  ¡ D ]	\}}| 	d¡ q>tj
|
dd	 t |¡ qqd S )
NTr<   rC   )é
   r?   r@   )rÓ   r»   Féd   rE   )rž   rH   rI   rJ   rK   rL   rM   rÔ   ZspinesZset_visiblerR   rS   )r‚   Úout_dirÚalphabetrÓ   Zfontr:   r•   Ú	motif_dirÚcwm_typeÚcwmr]   rW   rX   r   Zspiner   r   r   Ú	plot_cwmsN  s   õýrá   c                 C   s  g }g }g }|   ¡ D ]\}}| |d ¡ | |d ¡ | |¡ q
tt |¡t |¡ƒ}tjdd\}}	|	jd||fdddd	 |	j||d
d t	|ƒD ]\}
}t
|ƒ}|	j|||
 ||
 fddd qM|	 d¡ |	 d¡ |	 d¡ |	 d¡ tj|dd t ¡  d S )NrŽ   r   ra   r@   r¬   z0.3gffffffæ?)r   )é   râ   )rÁ   rÍ   Z	linestylerâ   )ÚsrF   rØ   )ÚfontsizerÙ   ÚlogzHits per motifzSeqlets per motifrD   rE   )rž   Úappendr²   r+   rO   rL   rM   ZaxlineZscatterr.   r   ZannotateZ
set_yscaleZ
set_xscalerT   rU   rR   rS   )r¤   r]   r[   r\   r:   r”   r•   ZlimrW   rX   r9   ÚtxtÚshortr   r   r   Úplot_hit_vs_seqlet_counts`  s(    


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ré   c                 C   sn   t j t¡ d¡ ¡ }t|ƒ}|j| jdd|d}t	|dƒ}| 
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