# Parameters
data_name = "Bcl11a"
task_idxs = "0-213,216-278"
homer_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_scans"
modisco_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_modisco2019"

from matlas.modisco_report import call_motifDB_to_be_displayed, display_comparative_cell_types

load data from labcluster

Using TensorFlow backend.
2019-07-25 23:16:39,099 [WARNING] git-lfs not installed

homer_matches, modisco_matches = call_motifDB_to_be_displayed(task_idxs, homer_root, modisco_root)

display_comparative_cell_types(data_name, homer_matches, modisco_matches)

TF-MoDISco is using the TensorFlow backend.

CISBP ID of Bcl11a: M4453_1.02

Shared Cell types both TF-MoDISco and Homer finds Bcl11a

Cell type	Modisco	Homer
Megakaryocyte progenitor cell	Significance: 5.04151e-09	Significance: 0.00228844
Granulocyte monocyte progenitor primary cell	Significance: 1.83099e-10	Significance: 0.00106384
restingB	Significance: 1.9538e-09	Significance: 6.82857e-07
aB LPS+IL4	Significance: 1.19398e-07	Significance: 0.012594
mouse spleen B cells, CD43-,CD11b- (immature B cells)	Significance: 1.3556500000000002e-09	Significance: 0.00182463
ch12 with quintuple mt	Significance: 1.3009000000000001e-06	Significance: 0.0017989
ch12 wt with drug	Significance: 3.2411599999999997e-06	Significance: 0.0148971
CLP	Significance: 8.23585e-09	Significance: 0.00397684

Unique Cell types only TF-MoDISco finds Bcl11a

Cell type	Modisco	Homer
preB cells	Significance: 5.97004e-12 Significance: 5.807419999999999e-06	absent
immature B cells	Significance: 1.26922e-09	absent
mature B cells	Significance: 1.7569200000000002e-09	absent
MZ B cells	Significance: 4.59277e-06	absent
B1 B cells	Significance: 2.4690700000000002e-06	absent
GC B cells	Significance: 9.760980000000002e-10	absent
Act B cell	Significance: 1.8865700000000002e-08	absent
aB LPS	Significance: 3.3010000000000003e-10	absent
Splenic B cell	Significance: 6.342290000000001e-10	absent
aB LPS+IL21	Significance: 6.62265e-06	absent
Bone marrow derived pre-B cell	Significance: 5.53914e-07	absent
aB aCD40+IL4	Significance: 3.6328699999999997e-10	absent
B220+CD43+ B cells	Significance: 4.20136e-10	absent
bone marrow-derived macrophages (Unstimulated)	Significance: 2.8293700000000003e-10	absent
bone marrow-derived macrophages(Lipid A stimulation 120min)	Significance: 1.52853e-07	absent
dendritic cell(100 ng/mL Lipopolysaccharide, 6hours)	Significance: 1.0244799999999998e-08	absent
Primary bone marrow derived dendritic cells (DCs, control vector)	Significance: 4.6223800000000003e-10 Significance: 0.00629245	absent
CH12.LX cell line	Significance: 8.60428e-09	absent
MEL cell line treated with 125 uM zinc dichloride for 24 hours	Significance: 0.0334911	absent
macrophage	Significance: 4.3184800000000005e-10	absent
spleen(adult-8wks)	Significance: 9.35551e-07	absent
Megakaryocyte primary cell	Significance: 1.02242e-10	absent
Common myeloid progenitor primary cell	Significance: 2.3702e-09	absent
dendritic cell(100 ng/mL Lipopolysaccharide, 4hours)	Significance: 1.8325999999999998e-06	absent
dendritic in vitro differentiated cells	Significance: 2.15443e-07	absent
Murine B-lymphoma cell line(A20 cell line)	Significance: 8.5265e-09	absent
gamma delta TCR Marco	Significance: 1.03789e-08	absent
acute myeloid leukemia	Significance: 2.0631599999999996e-10	absent
Act B cell 24h	Significance: 9.150060000000001e-06	absent
ch12 wt	Significance: 6.01087e-07	absent
mouse spleen B cells, CD43-,CD11b- (immature B cells)	Significance: 8.34797e-06	absent

Unique Cell types only Homer finds Bcl11a

Cell type	Modisco	Homer
aB LPS+a-d-dextran	absent	Significance: 0.0234804
aBCD180	absent	Significance: 0.000497029
dendritic cell(100 ng/mL Lipopolysaccharide, 2hours)	absent	Significance: 0.00042028599999999997