# Parameters
data_name = "ES;F1216;A;GEO"
modisco_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_modisco2019"
tomtom_report_root = "http://mitra.stanford.edu/kundaje/msharmin/report/tomtom_outs/cells"
task_dir = "task_100-naivegw"
perf_file = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/fineFactorized/task_100-naivegw/NaiveauPRC.txt"
homer_root = "/srv/scratch/msharmin/mouse_hem/with_tfd/full_mouse50/Naive_scans"
reportfile = "/mnt/lab_data/kundaje/msharmin/annotations/filtering samples_MS2.xlsx"
sheetname = "filter23"

from matlas.reports import display_metadata

load data from labcluster

Using TensorFlow backend.
2019-08-30 19:02:26,076 [WARNING] git-lfs not installed

display_metadata(data_name, perf_file, reportfile, sheetname)

Sample Information

MetaData Name	Description
Cell type	mouse embryonic stem cells (F1216)
Cell Group	ES cells and embryonic tissues
Experiment Name	ATAC
Experiment Group	GEO

Pipeline Output

replicate	Naïve overlap peaks	IDR peaks	TSS enrichment (< 8 is very poor <10 is low)	Final number of unique mapping, dup-filtered, chrM filtered reads	Number of reads in called peak regions	Fraction of reads in called peak regions	Number of reads in promoter regions	Fraction of reads in promoter regions	Number of reads in enhancer regions	Fraction of reads in enhancer regions
rep1	148115	95272	9.1871	75743004	10188192	0.1345	7426944	0.0981	28133260	0.3715

Modelling Metadata

Metric	Value
auPRC	0.6992
Calibrated Recall at 50% FDR	0.144
Number of Positive Examples in Test Data	86037
Number of Negative Examples in Test Data	7984814
Imbalance Ratio in Test Data	0.0107
Test Chromosomes	chr2, chr3, chr19

from matlas.reports import display_paiwise_pattern_comparison
from matlas.reports import display_denovo_patterns

display_denovo_patterns(data_name, modisco_root=modisco_root)

TF-MoDISco is using the TensorFlow backend.

The following two links show list of Denovo Patterns and corresponding Motifs discovered by TF-MoDISco

Click here for Denovo Patterns by TF-MoDISco: #21

Pattern Name	TF Name(s)	Modisco
metacluster_0/pattern_0 # seqlets: 2145 SequenceContrib ScoresHyp_Contrib Scores	Ctcf, Ctcfl
metacluster_0/pattern_1 # seqlets: 2144 SequenceContrib ScoresHyp_Contrib Scores	Sp1, Sp2, Sp3, Klf3, Sp4, Sp5, Wt1, Maz, Klf6, Zbtb17, Klf1, Egr1, Klf15, Klf5, Zfp281, Klf4, Klf7, E2f4, Klf8, Klf12, Zfx, Egr2, Rela, Mxi1, Fli1, E2f1, Sall4, Srebf2, Usf2
metacluster_0/pattern_2 # seqlets: 2004 SequenceContrib ScoresHyp_Contrib Scores	Myc, Max, Tfap2c
metacluster_0/pattern_3 # seqlets: 1093 SequenceContrib ScoresHyp_Contrib Scores	Zfp740, Bcl6, Zscan10
metacluster_0/pattern_4 # seqlets: 922 SequenceContrib ScoresHyp_Contrib Scores	Nfyb, Nfyc, Nfya, Foxi1, Pbx3
metacluster_0/pattern_5 # seqlets: 646 SequenceContrib ScoresHyp_Contrib Scores	Gabpa, Elf1, Elk1, Elk4, Elk3, Ets1, Erg, Fev, Elf5, Etv5, Etv1, Etv4, Elf2, Elf4, Ehf, Etv6, XP_911724.4, Etv3, Spi1, Elf3, Etv2, Spdef
metacluster_0/pattern_6 # seqlets: 622 SequenceContrib ScoresHyp_Contrib Scores	Pou5f1, Nanog, Sox2, Pou2f2, Lef1
metacluster_0/pattern_7 # seqlets: 582 SequenceContrib ScoresHyp_Contrib Scores	Sox4, Sox3, Sox6, Sox17, Sox12, Sry, Sox14, Sox7, Sox9, Sox5, Sox11, Sox8, Sox18, Tcf7, Sox21, Sox30, Cux2, Sox15, Sox10, Tcf7l2, Tcf7l1
metacluster_0/pattern_8 # seqlets: 496 SequenceContrib ScoresHyp_Contrib Scores	Creb1, Atf1, Creb5, Atf7, Jdp2, Atf2, Crem, Tfe3, Srebf1, Tfec, Rxrb, Mlx, Tfeb, Usf1, Bhlhe40, Mitf, Arntl, Nfil3, Xbp1, Tef, Atf3, Jun, Clock, Mafb, Creb3l2, Dbp, Hlf
metacluster_0/pattern_9 # seqlets: 477 SequenceContrib ScoresHyp_Contrib Scores	Nrf1
metacluster_0/pattern_10 # seqlets: 384 SequenceContrib ScoresHyp_Contrib Scores	Tead4, Tead2, Tead1
metacluster_0/pattern_11 # seqlets: 373 SequenceContrib ScoresHyp_Contrib Scores	Fosl2, Fosb, Junb, Fosl1, Jund, Fos, Batf, Bach2, Nfe2l2, Bach1, Nfe2, Mafk, Mafa, Mafg, Maff, Nr1d2, Maf, Nfatc1
metacluster_0/pattern_12 # seqlets: 335 SequenceContrib ScoresHyp_Contrib Scores	Rfx3, Rfx2, Rfx1, Rfx4, Rfx7, Rfx6
metacluster_0/pattern_13 # seqlets: 294 SequenceContrib ScoresHyp_Contrib Scores	Six2, Six4, Six1
metacluster_0/pattern_14 # seqlets: 255 SequenceContrib ScoresHyp_Contrib Scores	Taf1, Yy1, Zfp42
metacluster_0/pattern_15 # seqlets: 231 SequenceContrib ScoresHyp_Contrib Scores	Zfp143, Thap11, Tbx2
metacluster_0/pattern_16 # seqlets: 123 SequenceContrib ScoresHyp_Contrib Scores	Zbtb33
metacluster_0/pattern_17 # seqlets: 116 SequenceContrib ScoresHyp_Contrib Scores	Rest
metacluster_0/pattern_18 # seqlets: 81 SequenceContrib ScoresHyp_Contrib Scores
metacluster_0/pattern_19 # seqlets: 77 SequenceContrib ScoresHyp_Contrib Scores	Grhl2
metacluster_0/pattern_20 # seqlets: 49 SequenceContrib ScoresHyp_Contrib Scores

Click here for Motifs by TF-MoDISco: #157

TF Name	Pattern(s)
Ctcf	Pattern Name Modisco Significance metacluster_0/pattern_0 3.5598400000000003e-10
Ctcfl	Pattern Name Modisco Significance metacluster_0/pattern_0 2.45923e-11 metacluster_0/pattern_1 0.0105174 metacluster_0/pattern_2 0.0352774
Sp1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00034280599999999997 metacluster_0/pattern_2 0.0110871 metacluster_0/pattern_3 0.028064699999999998 metacluster_0/pattern_9 0.0446543 metacluster_0/pattern_14 0.00014477
Sp2	Pattern Name Modisco Significance metacluster_0/pattern_1 1.3808499999999999e-13 metacluster_0/pattern_2 0.00217147 metacluster_0/pattern_3 0.00116881 metacluster_0/pattern_9 0.010059299999999998 metacluster_0/pattern_14 1.73266e-05
Sp3	Pattern Name Modisco Significance metacluster_0/pattern_1 1.3808499999999999e-13 metacluster_0/pattern_2 0.00353545 metacluster_0/pattern_3 0.000314461 metacluster_0/pattern_14 0.000423841
Klf3	Pattern Name Modisco Significance metacluster_0/pattern_1 2.8256e-10 metacluster_0/pattern_2 0.044632599999999995 metacluster_0/pattern_3 0.00299524 metacluster_0/pattern_14 0.036338
Sp4	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00176817 metacluster_0/pattern_3 0.0537172
Sp5	Pattern Name Modisco Significance metacluster_0/pattern_1 1.3253e-07 metacluster_0/pattern_3 0.00013711299999999999
Wt1	Pattern Name Modisco Significance metacluster_0/pattern_1 5.723980000000001e-07 metacluster_0/pattern_3 0.00117129 metacluster_0/pattern_14 0.0251019
Maz	Pattern Name Modisco Significance metacluster_0/pattern_1 3.5530300000000005e-06 metacluster_0/pattern_3 0.000864318 metacluster_0/pattern_14 0.029062
Klf6	Pattern Name Modisco Significance metacluster_0/pattern_1 5.7005799999999996e-06 metacluster_0/pattern_3 0.012040100000000001
Zbtb17	Pattern Name Modisco Significance metacluster_0/pattern_1 8.98213e-06 metacluster_0/pattern_2 0.044632599999999995 metacluster_0/pattern_3 4.06828e-07 metacluster_0/pattern_14 0.0154405
Klf1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.048208600000000004
Egr1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00540035 metacluster_0/pattern_2 0.0372048 metacluster_0/pattern_3 0.0535538
Klf15	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00012880000000000001 metacluster_0/pattern_3 0.00424073
Klf5	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00020025099999999998 metacluster_0/pattern_3 0.00367573
Zfp281	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00039950900000000004 metacluster_0/pattern_3 0.00299524
Klf4	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00169078 metacluster_0/pattern_3 0.00299524
Klf7	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00107803 metacluster_0/pattern_3 0.0569773
E2f4	Pattern Name Modisco Significance metacluster_0/pattern_1 0.0014564 metacluster_0/pattern_3 0.046734899999999996
Klf8	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00218895 metacluster_0/pattern_3 0.059622
Klf12	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00234315
Zfx	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00587542 metacluster_0/pattern_2 0.017853900000000002 metacluster_0/pattern_9 0.0269877 metacluster_0/pattern_14 0.00545325
Egr2	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00772106 metacluster_0/pattern_3 0.00367573 metacluster_0/pattern_14 0.039236
Rela	Pattern Name Modisco Significance metacluster_0/pattern_1 0.012332 metacluster_0/pattern_3 0.047544800000000005
Mxi1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.012332 metacluster_0/pattern_2 0.00217147 metacluster_0/pattern_14 0.029062
Fli1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.0175012 metacluster_0/pattern_5 0.00682374
E2f1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.0175012 metacluster_0/pattern_3 0.041782599999999996
Sall4	Pattern Name Modisco Significance metacluster_0/pattern_1 0.030896499999999997 metacluster_0/pattern_3 0.0391673
Srebf2	Pattern Name Modisco Significance metacluster_0/pattern_1 0.039174 metacluster_0/pattern_3 0.0535538 metacluster_0/pattern_8 0.0229575
Usf2	Pattern Name Modisco Significance metacluster_0/pattern_1 0.058625300000000005 metacluster_0/pattern_2 0.00217147 metacluster_0/pattern_8 0.0551837
Myc	Pattern Name Modisco Significance metacluster_0/pattern_2 0.0185508
Max	Pattern Name Modisco Significance metacluster_0/pattern_2 0.044632599999999995
Tfap2c	Pattern Name Modisco Significance metacluster_0/pattern_2 0.0506718
Zfp740	Pattern Name Modisco Significance metacluster_0/pattern_3 0.012040100000000001
Bcl6	Pattern Name Modisco Significance metacluster_0/pattern_3 0.041782599999999996
Zscan10	Pattern Name Modisco Significance metacluster_0/pattern_3 0.0537047
Nfyb	Pattern Name Modisco Significance metacluster_0/pattern_4 1.13751e-12
Nfyc	Pattern Name Modisco Significance metacluster_0/pattern_4 2.2580799999999997e-09
Nfya	Pattern Name Modisco Significance metacluster_0/pattern_4 1.4500899999999998e-08
Foxi1	Pattern Name Modisco Significance metacluster_0/pattern_4 8.28403e-06
Pbx3	Pattern Name Modisco Significance metacluster_0/pattern_4 1.01196e-05
Gabpa	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00414435
Elf1	Pattern Name Modisco Significance metacluster_0/pattern_5 4.49065e-08
Elk1	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00404956
Elk4	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00599407
Elk3	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00404956
Ets1	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00720106
Erg	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00677743
Fev	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0032012
Elf5	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0114584
Etv5	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0032012
Etv1	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00414435
Etv4	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00599407
Elf2	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00936138
Elf4	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00507723
Ehf	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0071232
Etv6	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00550503
XP_911724.4	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00720106
Etv3	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00868099
Spi1	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0160847
Elf3	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0242261
Etv2	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0222773
Spdef	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0351514
Pou5f1	Pattern Name Modisco Significance metacluster_0/pattern_6 2.8354400000000002e-06 metacluster_0/pattern_7 0.024292400000000002 metacluster_0/pattern_12 0.050787
Nanog	Pattern Name Modisco Significance metacluster_0/pattern_6 3.01034e-09 metacluster_0/pattern_7 0.000166635
Sox2	Pattern Name Modisco Significance metacluster_0/pattern_6 2.8354400000000002e-06 metacluster_0/pattern_7 0.00903534 metacluster_0/pattern_12 0.033305400000000006
Pou2f2	Pattern Name Modisco Significance metacluster_0/pattern_6 0.0534078
Lef1	Pattern Name Modisco Significance metacluster_0/pattern_6 0.0406816 metacluster_0/pattern_7 0.00275747
Sox4	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00203124
Sox3	Pattern Name Modisco Significance metacluster_0/pattern_7 3.91971e-05
Sox6	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0232785
Sox17	Pattern Name Modisco Significance metacluster_0/pattern_7 0.000759563
Sox12	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00212072
Sry	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0572765
Sox14	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00789618
Sox7	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00821045
Sox9	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00821045
Sox5	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00852115
Sox11	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00854717
Sox8	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00935203
Sox18	Pattern Name Modisco Significance metacluster_0/pattern_7 0.013053700000000001
Tcf7	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0572765
Sox21	Pattern Name Modisco Significance metacluster_0/pattern_7 0.019726900000000002
Sox30	Pattern Name Modisco Significance metacluster_0/pattern_7 0.04008780000000001
Cux2	Pattern Name Modisco Significance metacluster_0/pattern_7 0.040179400000000004
Sox15	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0402483
Sox10	Pattern Name Modisco Significance metacluster_0/pattern_7 0.056690599999999994
Tcf7l2	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0594091
Tcf7l1	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0594091
Creb1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00166903
Atf1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0229575
Creb5	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0008943930000000001
Atf7	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00222004
Jdp2	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00775978 metacluster_0/pattern_11 0.000861143
Atf2	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00245673
Crem	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00751819
Tfe3	Pattern Name Modisco Significance metacluster_0/pattern_8 0.045507900000000004
Srebf1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0419957
Tfec	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0419957
Rxrb	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00939067
Mlx	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0169207
Tfeb	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0275523
Usf1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0275523
Bhlhe40	Pattern Name Modisco Significance metacluster_0/pattern_8 0.041774599999999995
Mitf	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0315233
Arntl	Pattern Name Modisco Significance metacluster_0/pattern_8 0.045507900000000004
Nfil3	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0229575
Xbp1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0229575
Tef	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0229575
Atf3	Pattern Name Modisco Significance metacluster_0/pattern_8 0.047148 metacluster_0/pattern_11 1.0390799999999999e-05
Jun	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0275523 metacluster_0/pattern_11 1.0390799999999999e-05
Clock	Pattern Name Modisco Significance metacluster_0/pattern_8 0.028611200000000003
Mafb	Pattern Name Modisco Significance metacluster_0/pattern_8 0.035289999999999995 metacluster_0/pattern_11 0.018416099999999998
Creb3l2	Pattern Name Modisco Significance metacluster_0/pattern_8 0.047148
Dbp	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0554933
Hlf	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0554933
Nrf1	Pattern Name Modisco Significance metacluster_0/pattern_9 1.26584e-06
Tead4	Pattern Name Modisco Significance metacluster_0/pattern_10 0.000392339
Tead2	Pattern Name Modisco Significance metacluster_0/pattern_10 0.00130259
Tead1	Pattern Name Modisco Significance metacluster_0/pattern_10 0.00241992
Fosl2	Pattern Name Modisco Significance metacluster_0/pattern_11 1.52205e-05
Fosb	Pattern Name Modisco Significance metacluster_0/pattern_11 1.9415e-05
Junb	Pattern Name Modisco Significance metacluster_0/pattern_11 2.49467e-05
Fosl1	Pattern Name Modisco Significance metacluster_0/pattern_11 2.49467e-05
Jund	Pattern Name Modisco Significance metacluster_0/pattern_11 0.022572799999999997
Fos	Pattern Name Modisco Significance metacluster_0/pattern_11 5.2278400000000004e-05
Batf	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00998947
Bach2	Pattern Name Modisco Significance metacluster_0/pattern_11 0.000672935
Nfe2l2	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00425319
Bach1	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00338771
Nfe2	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00380204
Mafk	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00998947
Mafa	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00998947
Mafg	Pattern Name Modisco Significance metacluster_0/pattern_11 0.014095600000000002
Maff	Pattern Name Modisco Significance metacluster_0/pattern_11 0.0190632
Nr1d2	Pattern Name Modisco Significance metacluster_0/pattern_11 0.0379755
Maf	Pattern Name Modisco Significance metacluster_0/pattern_11 0.0379755
Nfatc1	Pattern Name Modisco Significance metacluster_0/pattern_11 0.0394626
Rfx3	Pattern Name Modisco Significance metacluster_0/pattern_12 0.000527924
Rfx2	Pattern Name Modisco Significance metacluster_0/pattern_12 0.00748652
Rfx1	Pattern Name Modisco Significance metacluster_0/pattern_12 9.39822e-09 metacluster_0/pattern_14 0.0117312
Rfx4	Pattern Name Modisco Significance metacluster_0/pattern_12 1.06493e-05
Rfx7	Pattern Name Modisco Significance metacluster_0/pattern_12 0.0002108
Rfx6	Pattern Name Modisco Significance metacluster_0/pattern_12 0.000136207
Six2	Pattern Name Modisco Significance metacluster_0/pattern_13 2.26928e-06
Six4	Pattern Name Modisco Significance metacluster_0/pattern_13 8.54052e-06
Six1	Pattern Name Modisco Significance metacluster_0/pattern_13 0.00016411
Taf1	Pattern Name Modisco Significance metacluster_0/pattern_14 2.84938e-06
Yy1	Pattern Name Modisco Significance metacluster_0/pattern_14 1.73266e-05
Zfp42	Pattern Name Modisco Significance metacluster_0/pattern_14 0.0117793
Zfp143	Pattern Name Modisco Significance metacluster_0/pattern_15 4.513240000000001e-22
Thap11	Pattern Name Modisco Significance metacluster_0/pattern_15 1.09261e-20
Tbx2	Pattern Name Modisco Significance metacluster_0/pattern_15 5.67631e-14
Zbtb33	Pattern Name Modisco Significance metacluster_0/pattern_16 0.00021241400000000002
Rest	Pattern Name Modisco Significance metacluster_0/pattern_17 0.00411179 metacluster_0/pattern_18 1.87764e-18
Grhl2	Pattern Name Modisco Significance metacluster_0/pattern_19 0.000669125

display_paiwise_pattern_comparison(data_name, modisco_root, homer_root)

Number of CISBP TFs obtained by TF-MoDISco and Homer

Shared TFs between TF-MoDISco and Homer: #78

TF Name	Modisco	Homer
Nfya	Pattern Name Modisco Significance metacluster_0/pattern_4 1.4500899999999998e-08	Pattern Name Homer Significance motif4.motif 4.85173e-08
Creb1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00166903	Pattern Name Homer Significance motif12.motif 0.011071899999999999
Etv1	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00414435	Pattern Name Homer Significance motif9.motif 0.021432299999999998
Atf2	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00245673	Pattern Name Homer Significance motif12.motif 0.0009296039999999999
Gabpa	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00414435	Pattern Name Homer Significance motif9.motif 0.0200197
Jdp2	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00775978 metacluster_0/pattern_11 0.000861143	Pattern Name Homer Significance motif12.motif 0.00632821
Pbx3	Pattern Name Modisco Significance metacluster_0/pattern_4 1.01196e-05	Pattern Name Homer Significance motif4.motif 0.000160364
Etv3	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00868099	Pattern Name Homer Significance motif9.motif 0.0379237
Tfec	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0419957	Pattern Name Homer Significance motif19.motif 0.00173992
Tfe3	Pattern Name Modisco Significance metacluster_0/pattern_8 0.045507900000000004	Pattern Name Homer Significance motif19.motif 0.00164564
Srebf2	Pattern Name Modisco Significance metacluster_0/pattern_1 0.039174 metacluster_0/pattern_3 0.0535538 metacluster_0/pattern_8 0.0229575	Pattern Name Homer Significance motif19.motif 0.0174092
Zfp143	Pattern Name Modisco Significance metacluster_0/pattern_15 4.513240000000001e-22	Pattern Name Homer Significance motif3.motif 5.3201e-08
Creb3l2	Pattern Name Modisco Significance metacluster_0/pattern_8 0.047148	Pattern Name Homer Significance motif19.motif 0.014668700000000002
Zbtb17	Pattern Name Modisco Significance metacluster_0/pattern_1 8.98213e-06 metacluster_0/pattern_2 0.044632599999999995 metacluster_0/pattern_3 4.06828e-07 metacluster_0/pattern_14 0.0154405	Pattern Name Homer Significance motif2.motif 0.0484759
Egr2	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00772106 metacluster_0/pattern_3 0.00367573 metacluster_0/pattern_14 0.039236	Pattern Name Homer Significance motif2.motif 0.05670650000000001
Ctcf	Pattern Name Modisco Significance metacluster_0/pattern_0 3.5598400000000003e-10	Pattern Name Homer Significance motif1.motif 5.54631e-07
Thap11	Pattern Name Modisco Significance metacluster_0/pattern_15 1.09261e-20	Pattern Name Homer Significance motif3.motif 3.03915e-08
Pou5f1	Pattern Name Modisco Significance metacluster_0/pattern_6 2.8354400000000002e-06 metacluster_0/pattern_7 0.024292400000000002 metacluster_0/pattern_12 0.050787	Pattern Name Homer Significance motif7.motif 5.26145e-08
Klf6	Pattern Name Modisco Significance metacluster_0/pattern_1 5.7005799999999996e-06 metacluster_0/pattern_3 0.012040100000000001	Pattern Name Homer Significance motif2.motif 0.000937773
Klf5	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00020025099999999998 metacluster_0/pattern_3 0.00367573	Pattern Name Homer Significance motif2.motif 0.0259488
Klf7	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00107803 metacluster_0/pattern_3 0.0569773	Pattern Name Homer Significance motif2.motif 0.000619111
Elk4	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00599407	Pattern Name Homer Significance motif9.motif 0.027423700000000002
Nfyb	Pattern Name Modisco Significance metacluster_0/pattern_4 1.13751e-12	Pattern Name Homer Significance motif4.motif 4.85173e-08
Zbtb33	Pattern Name Modisco Significance metacluster_0/pattern_16 0.00021241400000000002	Pattern Name Homer Significance motif14.motif 0.00156834
Erg	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00677743	Pattern Name Homer Significance motif9.motif 0.031036599999999998
Elf2	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00936138	Pattern Name Homer Significance motif9.motif 0.0220491
Etv5	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0032012	Pattern Name Homer Significance motif9.motif 0.010929799999999998
Fev	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0032012	Pattern Name Homer Significance motif9.motif 0.0148159
Usf1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0275523	Pattern Name Homer Significance motif19.motif 0.00416974
Klf12	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00234315	Pattern Name Homer Significance motif2.motif 0.0144329
Elk3	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00404956	Pattern Name Homer Significance motif9.motif 0.0198995
Creb5	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0008943930000000001	Pattern Name Homer Significance motif12.motif 0.00109776
Atf7	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00222004	Pattern Name Homer Significance motif12.motif 0.000765645
Xbp1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0229575	Pattern Name Homer Significance motif19.motif 0.014121200000000002
Clock	Pattern Name Modisco Significance metacluster_0/pattern_8 0.028611200000000003	Pattern Name Homer Significance motif19.motif 0.0305443
E2f1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.0175012 metacluster_0/pattern_3 0.041782599999999996	Pattern Name Homer Significance motif2.motif 0.0463466
Klf1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.048208600000000004	Pattern Name Homer Significance motif2.motif 0.0484759
Rest	Pattern Name Modisco Significance metacluster_0/pattern_17 0.00411179 metacluster_0/pattern_18 1.87764e-18	Pattern Name Homer Significance motif24.motif 0.013324
Max	Pattern Name Modisco Significance metacluster_0/pattern_2 0.044632599999999995	Pattern Name Homer Significance motif19.motif 0.052728199999999996
Ctcfl	Pattern Name Modisco Significance metacluster_0/pattern_0 2.45923e-11 metacluster_0/pattern_1 0.0105174 metacluster_0/pattern_2 0.0352774	Pattern Name Homer Significance motif1.motif 8.506639999999999e-05
Zfx	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00587542 metacluster_0/pattern_2 0.017853900000000002 metacluster_0/pattern_9 0.0269877 metacluster_0/pattern_14 0.00545325	Pattern Name Homer Significance motif2.motif 0.0259488
Tbx2	Pattern Name Modisco Significance metacluster_0/pattern_15 5.67631e-14	Pattern Name Homer Significance motif3.motif 2.12825e-05
Atf1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0229575	Pattern Name Homer Significance motif12.motif 0.000787719
Bhlhe40	Pattern Name Modisco Significance metacluster_0/pattern_8 0.041774599999999995	Pattern Name Homer Significance motif19.motif 0.0113352
Elf1	Pattern Name Modisco Significance metacluster_0/pattern_5 4.49065e-08	Pattern Name Homer Significance motif9.motif 0.00931741
Elf5	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0114584	Pattern Name Homer Significance motif9.motif 0.0198995
E2f4	Pattern Name Modisco Significance metacluster_0/pattern_1 0.0014564 metacluster_0/pattern_3 0.046734899999999996	Pattern Name Homer Significance motif2.motif 0.0005947130000000001
Mlx	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0169207	Pattern Name Homer Significance motif19.motif 0.00387469
Etv4	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00599407	Pattern Name Homer Significance motif9.motif 0.0220491
Nrf1	Pattern Name Modisco Significance metacluster_0/pattern_9 1.26584e-06	Pattern Name Homer Significance motif11.motif 0.000295421
Sp2	Pattern Name Modisco Significance metacluster_0/pattern_1 1.3808499999999999e-13 metacluster_0/pattern_2 0.00217147 metacluster_0/pattern_3 0.00116881 metacluster_0/pattern_9 0.010059299999999998 metacluster_0/pattern_14 1.73266e-05	Pattern Name Homer Significance motif2.motif 8.623959999999999e-05
Klf3	Pattern Name Modisco Significance metacluster_0/pattern_1 2.8256e-10 metacluster_0/pattern_2 0.044632599999999995 metacluster_0/pattern_3 0.00299524 metacluster_0/pattern_14 0.036338	Pattern Name Homer Significance motif2.motif 0.000169083
Foxi1	Pattern Name Modisco Significance metacluster_0/pattern_4 8.28403e-06	Pattern Name Homer Significance motif4.motif 0.000155313
Srebf1	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0419957	Pattern Name Homer Significance motif19.motif 0.014332399999999999
Sp4	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00176817 metacluster_0/pattern_3 0.0537172	Pattern Name Homer Significance motif2.motif 0.0259488
Sox2	Pattern Name Modisco Significance metacluster_0/pattern_6 2.8354400000000002e-06 metacluster_0/pattern_7 0.00903534 metacluster_0/pattern_12 0.033305400000000006	Pattern Name Homer Significance motif7.motif 9.77417e-06
Tfeb	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0275523	Pattern Name Homer Significance motif19.motif 0.000144149
Ets1	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00720106	Pattern Name Homer Significance motif9.motif 0.0379237
Myc	Pattern Name Modisco Significance metacluster_0/pattern_2 0.0185508	Pattern Name Homer Significance motif19.motif 0.047089400000000003
Elf4	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00507723	Pattern Name Homer Significance motif9.motif 0.027423700000000002
Elk1	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00404956	Pattern Name Homer Significance motif9.motif 0.0198995
Atf3	Pattern Name Modisco Significance metacluster_0/pattern_8 0.047148 metacluster_0/pattern_11 1.0390799999999999e-05	Pattern Name Homer Significance motif12.motif 0.041679
Egr1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00540035 metacluster_0/pattern_2 0.0372048 metacluster_0/pattern_3 0.0535538	Pattern Name Homer Significance motif2.motif 0.019259900000000003
Usf2	Pattern Name Modisco Significance metacluster_0/pattern_1 0.058625300000000005 metacluster_0/pattern_2 0.00217147 metacluster_0/pattern_8 0.0551837	Pattern Name Homer Significance motif19.motif 0.00130582
Sp1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00034280599999999997 metacluster_0/pattern_2 0.0110871 metacluster_0/pattern_3 0.028064699999999998 metacluster_0/pattern_9 0.0446543 metacluster_0/pattern_14 0.00014477	Pattern Name Homer Significance motif2.motif 0.00686697
Pou2f2	Pattern Name Modisco Significance metacluster_0/pattern_6 0.0534078	Pattern Name Homer Significance motif7.motif 0.0150155
Etv6	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00550503	Pattern Name Homer Significance motif9.motif 0.031036599999999998
Fli1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.0175012 metacluster_0/pattern_5 0.00682374	Pattern Name Homer Significance motif9.motif 0.031036599999999998
Arntl	Pattern Name Modisco Significance metacluster_0/pattern_8 0.045507900000000004	Pattern Name Homer Significance motif19.motif 0.00130582
Sp3	Pattern Name Modisco Significance metacluster_0/pattern_1 1.3808499999999999e-13 metacluster_0/pattern_2 0.00353545 metacluster_0/pattern_3 0.000314461 metacluster_0/pattern_14 0.000423841	Pattern Name Homer Significance motif2.motif 8.623959999999999e-05
Nanog	Pattern Name Modisco Significance metacluster_0/pattern_6 3.01034e-09 metacluster_0/pattern_7 0.000166635	Pattern Name Homer Significance motif7.motif 3.2758199999999997e-06
Ehf	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0071232	Pattern Name Homer Significance motif9.motif 0.0379237
Klf4	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00169078 metacluster_0/pattern_3 0.00299524	Pattern Name Homer Significance motif2.motif 0.0005947130000000001
Klf8	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00218895 metacluster_0/pattern_3 0.059622	Pattern Name Homer Significance motif2.motif 0.00122736
Nfyc	Pattern Name Modisco Significance metacluster_0/pattern_4 2.2580799999999997e-09	Pattern Name Homer Significance motif4.motif 1.83402e-07
Mitf	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0315233	Pattern Name Homer Significance motif19.motif 0.00389806
Crem	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00751819	Pattern Name Homer Significance motif12.motif 0.0327346
XP_911724.4	Pattern Name Modisco Significance metacluster_0/pattern_5 0.00720106	Pattern Name Homer Significance motif9.motif 0.0379237

Unique TF-MoDISco TFs: #79

TF Name	Modisco	Homer
Rfx7	Pattern Name Modisco Significance metacluster_0/pattern_12 0.0002108	Absent
Rela	Pattern Name Modisco Significance metacluster_0/pattern_1 0.012332 metacluster_0/pattern_3 0.047544800000000005	Absent
Rfx1	Pattern Name Modisco Significance metacluster_0/pattern_12 9.39822e-09 metacluster_0/pattern_14 0.0117312	Absent
Wt1	Pattern Name Modisco Significance metacluster_0/pattern_1 5.723980000000001e-07 metacluster_0/pattern_3 0.00117129 metacluster_0/pattern_14 0.0251019	Absent
Rfx3	Pattern Name Modisco Significance metacluster_0/pattern_12 0.000527924	Absent
Tead4	Pattern Name Modisco Significance metacluster_0/pattern_10 0.000392339	Absent
Etv2	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0222773	Absent
Maz	Pattern Name Modisco Significance metacluster_0/pattern_1 3.5530300000000005e-06 metacluster_0/pattern_3 0.000864318 metacluster_0/pattern_14 0.029062	Absent
Tead1	Pattern Name Modisco Significance metacluster_0/pattern_10 0.00241992	Absent
Sox5	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00852115	Absent
Tef	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0229575	Absent
Jund	Pattern Name Modisco Significance metacluster_0/pattern_11 0.022572799999999997	Absent
Nr1d2	Pattern Name Modisco Significance metacluster_0/pattern_11 0.0379755	Absent
Fosb	Pattern Name Modisco Significance metacluster_0/pattern_11 1.9415e-05	Absent
Klf15	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00012880000000000001 metacluster_0/pattern_3 0.00424073	Absent
Spi1	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0160847	Absent
Sox15	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0402483	Absent
Spdef	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0351514	Absent
Nfatc1	Pattern Name Modisco Significance metacluster_0/pattern_11 0.0394626	Absent
Sox21	Pattern Name Modisco Significance metacluster_0/pattern_7 0.019726900000000002	Absent
Sox4	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00203124	Absent
Nfe2	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00380204	Absent
Sox11	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00854717	Absent
Yy1	Pattern Name Modisco Significance metacluster_0/pattern_14 1.73266e-05	Absent
Mafg	Pattern Name Modisco Significance metacluster_0/pattern_11 0.014095600000000002	Absent
Tfap2c	Pattern Name Modisco Significance metacluster_0/pattern_2 0.0506718	Absent
Taf1	Pattern Name Modisco Significance metacluster_0/pattern_14 2.84938e-06	Absent
Hlf	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0554933	Absent
Rxrb	Pattern Name Modisco Significance metacluster_0/pattern_8 0.00939067	Absent
Tcf7l1	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0594091	Absent
Sox17	Pattern Name Modisco Significance metacluster_0/pattern_7 0.000759563	Absent
Mxi1	Pattern Name Modisco Significance metacluster_0/pattern_1 0.012332 metacluster_0/pattern_2 0.00217147 metacluster_0/pattern_14 0.029062	Absent
Zfp281	Pattern Name Modisco Significance metacluster_0/pattern_1 0.00039950900000000004 metacluster_0/pattern_3 0.00299524	Absent
Bach1	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00338771	Absent
Sox30	Pattern Name Modisco Significance metacluster_0/pattern_7 0.04008780000000001	Absent
Six4	Pattern Name Modisco Significance metacluster_0/pattern_13 8.54052e-06	Absent
Sox3	Pattern Name Modisco Significance metacluster_0/pattern_7 3.91971e-05	Absent
Tead2	Pattern Name Modisco Significance metacluster_0/pattern_10 0.00130259	Absent
Maf	Pattern Name Modisco Significance metacluster_0/pattern_11 0.0379755	Absent
Sox18	Pattern Name Modisco Significance metacluster_0/pattern_7 0.013053700000000001	Absent
Rfx6	Pattern Name Modisco Significance metacluster_0/pattern_12 0.000136207	Absent
Fosl1	Pattern Name Modisco Significance metacluster_0/pattern_11 2.49467e-05	Absent
Tcf7	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0572765	Absent
Sry	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0572765	Absent
Zscan10	Pattern Name Modisco Significance metacluster_0/pattern_3 0.0537047	Absent
Maff	Pattern Name Modisco Significance metacluster_0/pattern_11 0.0190632	Absent
Sox9	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00821045	Absent
Sox7	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00821045	Absent
Mafk	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00998947	Absent
Jun	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0275523 metacluster_0/pattern_11 1.0390799999999999e-05	Absent
Cux2	Pattern Name Modisco Significance metacluster_0/pattern_7 0.040179400000000004	Absent
Six1	Pattern Name Modisco Significance metacluster_0/pattern_13 0.00016411	Absent
Sox10	Pattern Name Modisco Significance metacluster_0/pattern_7 0.056690599999999994	Absent
Zfp42	Pattern Name Modisco Significance metacluster_0/pattern_14 0.0117793	Absent
Sox8	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00935203	Absent
Six2	Pattern Name Modisco Significance metacluster_0/pattern_13 2.26928e-06	Absent
Dbp	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0554933	Absent
Fosl2	Pattern Name Modisco Significance metacluster_0/pattern_11 1.52205e-05	Absent
Zfp740	Pattern Name Modisco Significance metacluster_0/pattern_3 0.012040100000000001	Absent
Mafa	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00998947	Absent
Batf	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00998947	Absent
Nfe2l2	Pattern Name Modisco Significance metacluster_0/pattern_11 0.00425319	Absent
Rfx2	Pattern Name Modisco Significance metacluster_0/pattern_12 0.00748652	Absent
Sall4	Pattern Name Modisco Significance metacluster_0/pattern_1 0.030896499999999997 metacluster_0/pattern_3 0.0391673	Absent
Bach2	Pattern Name Modisco Significance metacluster_0/pattern_11 0.000672935	Absent
Sp5	Pattern Name Modisco Significance metacluster_0/pattern_1 1.3253e-07 metacluster_0/pattern_3 0.00013711299999999999	Absent
Sox6	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0232785	Absent
Elf3	Pattern Name Modisco Significance metacluster_0/pattern_5 0.0242261	Absent
Grhl2	Pattern Name Modisco Significance metacluster_0/pattern_19 0.000669125	Absent
Tcf7l2	Pattern Name Modisco Significance metacluster_0/pattern_7 0.0594091	Absent
Bcl6	Pattern Name Modisco Significance metacluster_0/pattern_3 0.041782599999999996	Absent
Mafb	Pattern Name Modisco Significance metacluster_0/pattern_8 0.035289999999999995 metacluster_0/pattern_11 0.018416099999999998	Absent
Fos	Pattern Name Modisco Significance metacluster_0/pattern_11 5.2278400000000004e-05	Absent
Rfx4	Pattern Name Modisco Significance metacluster_0/pattern_12 1.06493e-05	Absent
Lef1	Pattern Name Modisco Significance metacluster_0/pattern_6 0.0406816 metacluster_0/pattern_7 0.00275747	Absent
Sox12	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00212072	Absent
Sox14	Pattern Name Modisco Significance metacluster_0/pattern_7 0.00789618	Absent
Nfil3	Pattern Name Modisco Significance metacluster_0/pattern_8 0.0229575	Absent
Junb	Pattern Name Modisco Significance metacluster_0/pattern_11 2.49467e-05	Absent

Unique Homer TFs: #18

TF Name	Modisco	Homer
Npas2	Absent	Pattern Name Homer Significance motif19.motif 0.048338900000000004
Arnt	Absent	Pattern Name Homer Significance motif19.motif 0.0239713
Snai1	Absent	Pattern Name Homer Significance motif1.motif 0.043979199999999996
E2f7	Absent	Pattern Name Homer Significance motif2.motif 0.0463466
Hes2	Absent	Pattern Name Homer Significance motif19.motif 0.0458671
Hes1	Absent	Pattern Name Homer Significance motif19.motif 0.0458671
Mlxip	Absent	Pattern Name Homer Significance motif19.motif 0.0369668
Zic3	Absent	Pattern Name Homer Significance motif1.motif 0.043979199999999996
Pax2	Absent	Pattern Name Homer Significance motif19.motif 0.054432299999999996
Zbtb1	Absent	Pattern Name Homer Significance motif2.motif 0.0458251
Epas1	Absent	Pattern Name Homer Significance motif19.motif 0.053848
Hes5	Absent	Pattern Name Homer Significance motif19.motif 0.0458671
Zic2	Absent	Pattern Name Homer Significance motif1.motif 0.043979199999999996
Hey2	Absent	Pattern Name Homer Significance motif19.motif 0.014121200000000002
Arnt2	Absent	Pattern Name Homer Significance motif19.motif 0.047089400000000003
Tcfl5	Absent	Pattern Name Homer Significance motif19.motif 0.0177923
Bhlhe41	Absent	Pattern Name Homer Significance motif19.motif 0.00316771
Mycn	Absent	Pattern Name Homer Significance motif19.motif 0.0423537