******************************************************************************** MAST - Motif Alignment and Search Tool ******************************************************************************** MAST version 5.0.0 (Release date: Wed Oct 11 17:39:42 2017 -0700) For further information on how to interpret these results or to get a copy of the MAST software please access http://meme-suite.org . ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Michael Gribskov, "Combining evidence using p-values: application to sequence homology searches", Bioinformatics, 14(48-54), 1998. ******************************************************************************** ******************************************************************************** DATABASE AND MOTIFS ******************************************************************************** DATABASE adh.s (peptide) Last updated on Tue Feb 2 11:33:11 2016 Database contains 33 sequences, 9996 residues MOTIFS meme.adh.de.oops.xml (peptide) MOTIF ID ALT ID WIDTH BEST POSSIBLE MATCH ----- ------------------ ------ ----- ------------------- 1 LDLSGKVVJVTGAASGJG MEME-1 18 MDLQGKNVWVTGASCGIG 2 YSASKAAVASLTEALAFE MEME-2 18 YCASKWYVRMLTRCMAFE PAIRWISE MOTIF CORRELATIONS: MOTIF 1 ----- ----- 2 0.20 No overly similar pairs (correlation > 0.60) found. Random model letter frequencies (from non-redundant database): A 0.073 C 0.018 D 0.052 E 0.062 F 0.040 G 0.069 H 0.022 I 0.056 K 0.058 L 0.092 M 0.023 N 0.046 P 0.051 Q 0.041 R 0.052 S 0.074 T 0.059 V 0.064 W 0.013 Y 0.033 ******************************************************************************** ******************************************************************************** SECTION I: HIGH-SCORING SEQUENCES ******************************************************************************** - Each of the following 33 sequences has E-value less than 10. - The E-value of a sequence is the expected number of sequences in a random database of the same size that would match the motifs as well as the sequence does and is equal to the combined p-value of the sequence times the number of sequences in the database. - The combined p-value of a sequence measures the strength of the match of the sequence to all the motifs and is calculated by o finding the score of the single best match of each motif to the sequence (best matches may overlap), o calculating the sequence p-value of each score, o forming the product of the p-values, o taking the p-value of the product. - The sequence p-value of a score is defined as the probability of a random sequence of the same length containing some match with as good or better a score. - The score for the match of a position in a sequence to a motif is computed by by summing the appropriate entry from each column of the position-dependent scoring matrix that represents the motif. - Sequences shorter than one or more of the motifs are skipped. - The table is sorted by increasing E-value. ******************************************************************************** SEQUENCE NAME DESCRIPTION E-VALUE LENGTH ------------- ----------- -------- ------ YINL_LISMO HYPOTHETICAL 26.8 KD PROTE... 2.9e-19 248 3BHD_COMTE 3-BETA-HYDROXYSTEROID DEHY... 1.1e-18 253 2BHD_STREX 20-BETA-HYDROXYSTEROID DEH... 1.4e-18 255 YRTP_BACSU HYPOTHETICAL 25.3 KD PROTE... 1.8e-18 238 HDHA_ECOLI 7-ALPHA-HYDROXYSTEROID DEH... 6.3e-18 255 ENTA_ECOLI 2,3-DIHYDRO-2,3-DIHYDROXYB... 2.1e-17 248 FVT1_HUMAN no comment 2.4e-17 332 AP27_MOUSE ADIPOCYTE P27 PROTEIN (AP27) 2.6e-17 244 DHMA_FLAS1 N-ACYLMANNOSAMINE 1-DEHYDR... 8.5e-17 270 DHII_HUMAN CORTICOSTEROID 11-BETA-DEH... 2.6e-16 292 HDE_CANTR HYDRATASE-DEHYDROGENASE-EP... 7.2e-16 906 NODG_RHIME NODULATION PROTEIN G (HOST... 1.3e-15 245 DHB3_HUMAN no comment 1.9e-15 310 BPHB_PSEPS BIPHENYL-CIS-DIOL DEHYDROG... 2.2e-15 275 RIDH_KLEAE RIBITOL 2-DEHYDROGENASE (E... 2.4e-15 249 DHB2_HUMAN no comment 6.1e-15 387 DHGB_BACME GLUCOSE 1-DEHYDROGENASE B ... 8.6e-15 262 RFBB_NEIGO no comment 1.8e-14 346 BDH_HUMAN D-BETA-HYDROXYBUTYRATE DEH... 9.3e-14 343 FIXR_BRAJA FIXR PROTEIN 2.2e-13 278 BUDC_KLETE ACETOIN(DIACETYL) REDUCTAS... 1.6e-12 241 DHES_HUMAN ESTRADIOL 17 BETA-DEHYDROG... 8.7e-12 327 LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC ... 1e-11 305 PCR_PEA no comment 2.7e-11 399 YURA_MYXXA no comment 7.9e-11 258 HMTR_LEIMA no comment 1.7e-10 287 GUTD_ECOLI SORBITOL-6-PHOSPHATE 2-DEH... 9e-09 259 BA72_EUBSP 7-ALPHA-HYDROXYSTEROID DEH... 1.3e-08 249 CSGA_MYXXA no comment 3e-08 166 FABI_ECOLI no comment 3.1e-08 262 ADH_DROME ALCOHOL DEHYDROGENASE (EC ... 6e-08 255 DHCA_HUMAN no comment 9e-07 276 MAS1_AGRRA no comment 3.9e-06 476 ******************************************************************************** ******************************************************************************** SECTION II: MOTIF DIAGRAMS ******************************************************************************** - The ordering and spacing of all non-overlapping motif occurrences are shown for each high-scoring sequence listed in Section I. - A motif occurrence is defined as a position in the sequence whose match to the motif has POSITION p-value less than 0.0001. - The POSITION p-value of a match is the probability of a single random subsequence of the length of the motif scoring at least as well as the observed match. - For each sequence, all motif occurrences are shown unless there are overlaps. In that case, a motif occurrence is shown only if its p-value is less than the product of the p-values of the other (lower-numbered) motif occurrences that it overlaps. - The table also shows the E-value of each sequence. - Spacers and motif occurences are indicated by o -d- `d' residues separate the end of the preceding motif occurrence and the start of the following motif occurrence o [n] occurrence of motif `n' with p-value less than 0.0001. ******************************************************************************** SEQUENCE NAME E-VALUE MOTIF DIAGRAM ------------- -------- ------------- YINL_LISMO 2.9e-19 [1]-135-[2]-77 3BHD_COMTE 1.1e-18 1-[1]-56-[1]-57-[2]-85 2BHD_STREX 1.4e-18 1-[1]-132-[2]-86 YRTP_BACSU 1.8e-18 1-[1]-135-[2]-66 HDHA_ECOLI 6.3e-18 6-[1]-134-[2]-79 ENTA_ECOLI 2.1e-17 [1]-[2]-81-[1]-8-[2]-87 FVT1_HUMAN 2.4e-17 27-[1]-64-[1]-58-[2]-129 AP27_MOUSE 2.6e-17 2-[1]-128-[2]-78 DHMA_FLAS1 8.5e-17 9-[1]-54-[1]-65-[2]-88 DHII_HUMAN 2.6e-16 29-[1]-34-[2]-83-[2]-92 HDE_CANTR 7.2e-16 3-[1]-141-[2]-3-[2]-116-[1]-131-[2]-41-[1]-363 NODG_RHIME 1.3e-15 1-[1]-108-[1]-6-[2]-76 DHB3_HUMAN 1.9e-15 43-[1]-136-[2]-95 BPHB_PSEPS 2.2e-15 [1]-134-[2]-105 RIDH_KLEAE 2.4e-15 9-[1]-132-[2]-72 DHB2_HUMAN 6.1e-15 77-[1]-136-[2]-138 DHGB_BACME 8.6e-15 2-[1]-139-[2]-85 RFBB_NEIGO 1.8e-14 1-[1]-145-[2]-164 BDH_HUMAN 9.3e-14 50-[1]-139-[2]-118 FIXR_BRAJA 2.2e-13 31-[1]-139-[2]-72 BUDC_KLETE 1.6e-12 74-[1]-53-[2]-4-[1]-56 DHES_HUMAN 8.7e-12 129-[1]-7-[2]-155 LIGD_PSEPA 1e-11 1-[1]-137-[2]-131 PCR_PEA 2.7e-11 81-[1]-168-[2]-114 YURA_MYXXA 7.9e-11 153-[2]-4-[1]-65 HMTR_LEIMA 1.7e-10 1-[1]-11-[2]-144-[2]-77 GUTD_ECOLI 9e-09 129-[1]-6-[2]-88 BA72_EUBSP 1.3e-08 1-[1]-[2]-119-[2]-75 CSGA_MYXXA 3e-08 12-[1]-57-[2]-61 FABI_ECOLI 3.1e-08 1-[1]-2-[2]-223 ADH_DROME 6e-08 1-[1]-132-[2]-86 DHCA_HUMAN 9e-07 77-[1]-97-[2]-2-[1]-46 MAS1_AGRRA 3.9e-06 162-[2]-60-[1]-42-[1]-73-[2]-67 ******************************************************************************** ******************************************************************************** SECTION III: ANNOTATED SEQUENCES ******************************************************************************** - The positions and p-values of the non-overlapping motif occurrences are shown above the actual sequence for each of the high-scoring sequences from Section I. - A motif occurrence is defined as a position in the sequence whose match to the motif has POSITION p-value less than 0.0001 as defined in Section II. - For each sequence, the first line specifies the name of the sequence. - The second (and possibly more) lines give a description of the sequence. - Following the description line(s) is a line giving the length, combined p-value, and E-value of the sequence as defined in Section I. - The next line reproduces the motif diagram from Section II. - The entire sequence is printed on the following lines. - Motif occurrences are indicated directly above their positions in the sequence on lines showing o the motif number of the occurrence, o the position p-value of the occurrence, o the best possible match to the motif, and o columns whose match to the motif has a positive score (indicated by a plus sign). ******************************************************************************** YINL_LISMO HYPOTHETICAL 26.8 KD PROTEIN IN INLA 5'REGION (ORFA) LENGTH = 248 COMBINED P-VALUE = 8.85e-21 E-VALUE = 2.9e-19 DIAGRAM: [1]-135-[2]-77 [1] 1.5e-14 MDLQGKNVWVTGASCGIG ++++++++++++++++++ 1 MTIKNKVIIITGASSGIGKATALLLAEKGAKLVLAARRVEKLEKIVQIIKANSGEAIFAKTDVTKREDNKKLVEL [2] 2.2e-13 YCASKWYVRMLTRCMAFE +++++++++ ++++++++ 151 GAVYGATKWAVRDLMEVLRMESAQEGTNIRTATIYPAAINTELLETITDKETEQGMTSLYKQYGITPDRIASIVA 3BHD_COMTE 3-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.51) LENGTH = 253 COMBINED P-VALUE = 3.21e-20 E-VALUE = 1.1e-18 DIAGRAM: 1-[1]-56-[1]-57-[2]-85 [1] 1.1e-14 MDLQGKNVWVTGASCGIG ++++++++++++++++++ 1 TNRLQGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELGERSMFVRHDVSSEADWTLVMAAVQ [1] 7.7e-06 MDLQGKNVWVTGASCGIG ++++ ++++++ ++ + 76 RRLGTLNVLVNNAGILLPGDMETGRLEDFSRLLKINTESVFIGCQQGIAAMKETGGSIINMASVSSWLPIEQYAG [2] 1.1e-12 YCASKWYVRMLTRCMAFE ++++++++++++++ +++ 151 YSASKAAVSALTRAAALSCRKQGYAIRVNSIHPDGIYTPMMQASLPKGVSKEMVLHDPKLNRAGRAYMPERIAQL 2BHD_STREX 20-BETA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.53) LENGTH = 255 COMBINED P-VALUE = 4.38e-20 E-VALUE = 1.4e-18 DIAGRAM: 1-[1]-132-[2]-86 [1] 1.9e-14 MDLQGKNVWVTGASCGIG ++++++++++++++++++ 1 MNDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDWQRVVAYAR [2] 8.1e-13 YCASKWYVRMLTRCMAFE ++++++++++++++ +++ 151 SYGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGNYPNTPMGRVGNEPGEIAGAVVKLL YRTP_BACSU HYPOTHETICAL 25.3 KD PROTEIN IN RTP 5'REGION (ORF238) LENGTH = 238 COMBINED P-VALUE = 5.56e-20 E-VALUE = 1.8e-18 DIAGRAM: 1-[1]-135-[2]-66 [1] 1.6e-13 MDLQGKNVWVTGASCGIG ++++++++++++++++++ 1 MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVEKVAEEVKALGVKAAFAAADVKDADQVNQAVA [2] 1.4e-13 YCASKWYVRMLTRCMAFE ++++++++ ++++++ ++ 151 VTSAYSASKFAVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVAQLKLDPR HDHA_ECOLI 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (HSDH) LENGTH = 255 COMBINED P-VALUE = 1.92e-19 E-VALUE = 6.3e-18 DIAGRAM: 6-[1]-134-[2]-79 [1] 5.8e-14 MDLQGKNVWVTGASCGIG ++++++++++++++ +++ 1 MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFACRCDITSEQEL [2] 1.2e-12 YCASKWYVRMLTRCMAFE +++++++ ++++++++++ 151 NKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSVITPEIEQKMLQHTPIRRLGQPQDIA ENTA_ECOLI 2,3-DIHYDRO-2,3-DIHYDROXYBENZOATE DEHYDROGENASE (EC 1.3.1.28) LENGTH = 248 COMBINED P-VALUE = 6.26e-19 E-VALUE = 2.1e-17 DIAGRAM: [1]-[2]-81-[1]-8-[2]-87 [1] [2] 8.7e-18 4.3e-08 MDLQGKNVWVTGASCGIGYCASKWYVRMLTRCMAFE ++++++++++++++++++++ + +++++ +++++++ 1 MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDA [1] [2] 5.0e-05 2.9e-08 MDLQGKNVWVTGASCGIG YCASKWY ++ + ++++ ++ +++++++ 76 LVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAA VRMLTRCMAFE + +++ + +++ 151 LKSLALSVGLELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFL FVT1_HUMAN no comment LENGTH = 332 COMBINED P-VALUE = 7.21e-19 E-VALUE = 2.4e-17 DIAGRAM: 27-[1]-64-[1]-58-[2]-129 [1] 3.6e-11 MDLQGKNVWVTGASCGIG + + + ++++++++++++ 1 MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKE [1] 1.9e-05 MDLQGKNVWVTGASCGIG + +++ +++++++ + 76 IEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSV [2] 4.4e-15 YCASKWYVRMLTRCMAFE ++++++++++++++++++ 151 YPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFA AP27_MOUSE ADIPOCYTE P27 PROTEIN (AP27) LENGTH = 244 COMBINED P-VALUE = 8.02e-19 E-VALUE = 2.6e-17 DIAGRAM: 2-[1]-128-[2]-78 [1] 9.7e-13 MDLQGKNVWVTGASCGIG + ++++++++++++++++ 1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDATEKALGGIG [2 3. YC ++ 76 PVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYS ] 5e-13 ASKWYVRMLTRCMAFE +++ ++++++++++++ 151 STKGAMTMLTKAMAMELGPHKIRVNSVNPTVVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSD DHMA_FLAS1 N-ACYLMANNOSAMINE 1-DEHYDROGENASE (EC 1.1.1.233) (NAM-DH) LENGTH = 270 COMBINED P-VALUE = 2.57e-18 E-VALUE = 8.5e-17 DIAGRAM: 9-[1]-54-[1]-65-[2]-88 [1] 5.8e-14 MDLQGKNVWVTGASCGIG ++ ++++++++++++++ 1 TTAGVSRRPGRLAGKAAIVTGAAGGIGRATVEAYLREGASVVAMDLAPRLAATRYEEPGAIPIACDLADRAAIDA [1] 3.5e-05 MDLQGKNVWVTGASCGIG +++++ +++ +++ + + 76 AMADAVARLGGLDILVAGGALKGGTGNFLDLSDADWDRYVDVNMTGTFLTCRAGARMAVAAGAGKDGRSARIITI [2] 1.5e-11 YCASKWYVRMLTRCMAFE + +++ ++++++++++++ 151 GSVNSFMAEPEAAAYVAAKGGVAMLTRAMAVDLARHGILVNMIAPGPVDVTGNNTGYSEPRLAEQVLDEVALGRP DHII_HUMAN CORTICOSTEROID 11-BETA-DEHYDROGENASE (EC 1.1.1.146) (11-DH) (11-BETA- HYDROXYSTEROID DEHYDROGENASE) (11-BETA-HSD) LENGTH = 292 COMBINED P-VALUE = 7.78e-18 E-VALUE = 2.6e-16 DIAGRAM: 29-[1]-34-[2]-83-[2]-92 [1] 7.3e-16 MDLQGKNVWVTGASCGIG ++++++++++++++++++ 1 MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVV [2] 9.0e-05 YCASKWYVRMLTRCMAFE +++ +++++ ++ + + 76 SHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVL [2] 3.2e-09 YCASKWYVRMLTRCMAFE ++++++++++++ + + + 151 TVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMK HDE_CANTR HYDRATASE-DEHYDROGENASE-EPIMERASE (HDE) LENGTH = 906 COMBINED P-VALUE = 2.19e-17 E-VALUE = 7.2e-16 DIAGRAM: 3-[1]-141-[2]-3-[2]-116-[1]-131-[2]-41-[1]-363 [1] 1.6e-13 MDLQGKNVWVTGASCGIG +++++++++++++++++ 1 MSPVDFKDKVVIITGAGGGLGKYYSLEFAKLGAKVVVNDLGGALNGQGGNSKAADVVVDEIVKNGGVAVADYNNV [2] [2] 2.3e-07 3.8e-05 YCASKWYVRMLTRCMAFE YCASKWYVRMLTRCMAFE +++++ ++ +++++++ + + +++ ++++ ++ 151 PAGLYGNFGQANYASAKSALLGFAETLAKEGAKYNIKANAIAPLARSRMTESILPPPMLEKLGPEKVAPLVLYLS [1] 4.0e-12 MDLQGKNVWVTGASCGIG +++++++++++++ +++ 301 TNEARKLPANDASGAPTVSLKDKVVLITGAGAGLGKEYAKWFAKYGAKVVVNDFKDATKTVDEIKAAGGEAWPDQ [2] 4.0e-12 YCASKWYVRMLTRCMAFE ++++++++ +++++++ + 451 NITSTSGIYGNFGQANYSSSKAGILGLSKTMAIEGAKNNIKVNIVAPHAETAMTLTIFREQDKNLYHADQVAPLL [1] 6.9e-05 MDLQGKNVWVTGASCGIG ++ + +++ + ++ 526 VYLGTDDVPVTGETSEIGGGWIGNTRWQRAKGAVSHDEHTTVEFIKEHLNEITDFTTDTENPKSTTESSMAILSA NODG_RHIME NODULATION PROTEIN G (HOST-SPECIFICITY OF NODULATION PROTEIN C) LENGTH = 245 COMBINED P-VALUE = 3.92e-17 E-VALUE = 1.3e-15 DIAGRAM: 1-[1]-108-[1]-6-[2]-76 [1] 1.1e-11 MDLQGKNVWVTGASCGIG +++++++++++++++ ++ 1 MFELTGRKALVTGASGAIGGAIARVLHAQGAIVGLHGTQIEKLETLATELGDRVKLFPANLANRDEVKALGQRAE [1] 1.7e-06 MDLQGKNVWVTGASCGIG ++ ++ + ++ ++ ++ 76 ADLEGVDILVNNAGITKDGLFLHMADPDWDIVLEVNLTAMFRLTREITQQMIRRRNGRIINVTSVAGAIGNPGQT [2] 1.6e-12 YCASKWYVRMLTRCMAFE ++++++++ +++++++++ 151 NYCASKAGMIGFSKSLAQEIATRNITVNCVAPGFIESAMTDKLNHKQKEKIMVAIPIHRMGTGTEVASAVAYLAS DHB3_HUMAN no comment LENGTH = 310 COMBINED P-VALUE = 5.85e-17 E-VALUE = 1.9e-15 DIAGRAM: 43-[1]-136-[2]-95 [1] 2.0e-11 MDLQGKNVWVTGASCGIG ++ +++++++++++ +++ 1 MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYYKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNV [2] 8.1e-13 YCASKWYVRMLTRCMAFE ++++++++++++++++ + 151 QSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV BPHB_PSEPS BIPHENYL-CIS-DIOL DEHYDROGENASE (EC 1.3.1.-) LENGTH = 275 COMBINED P-VALUE = 6.57e-17 E-VALUE = 2.2e-15 DIAGRAM: [1]-134-[2]-105 [1] 1.2e-12 MDLQGKNVWVTGASCGIG + +++ ++++++++++++ 1 MKLKGEAVLITGGASGLGRALVDRFVAEAKVAVLDKSAERLAELETDLGDNVLGIVGDVRSLEDQKQAASRCVAR [2] 1.9e-11 YCASKWYVRMLTRCMAFE +++++ ++ ++++ ++++ 151 PLYTAAKQAIVGLVRELAFELAPYVRVNGVGPGGMNSDMRGPSSLGMGSKAISTVPLADMLKSVLPIGRMPEVEE RIDH_KLEAE RIBITOL 2-DEHYDROGENASE (EC 1.1.1.56) (RDH) LENGTH = 249 COMBINED P-VALUE = 7.23e-17 E-VALUE = 2.4e-15 DIAGRAM: 9-[1]-132-[2]-72 [1] 3.8e-13 MDLQGKNVWVTGASCGIG +++++++ +++++++++ 1 MKHSVSSMNTSLSGKVAAITGAASGIGLECARTLLGAGAKVVLIDREGEKLNKLVAELGENAFALQVDLMQADQV [2] 8.4e-11 YCASKWYVRMLTRCMAFE ++++++++++++++++++ 151 VVPVIWEPVYTASKFAVQAFVHTTRRQVAQYGVRVGAVLPGPVVTALLDDWPKAKMDEALANGSLMQPIEVAESV DHB2_HUMAN no comment LENGTH = 387 COMBINED P-VALUE = 1.86e-16 E-VALUE = 6.1e-15 DIAGRAM: 77-[1]-136-[2]-138 [1] 1.8e-11 MDLQGKNVWVTGASCGIG ++++++++++++++++++ 76 ELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYS [2] 1.8e-12 YCASKWYVRMLTRCMAFE ++++++++++++ +++++ 226 MERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI DHGB_BACME GLUCOSE 1-DEHYDROGENASE B (EC 1.1.1.47) LENGTH = 262 COMBINED P-VALUE = 2.59e-16 E-VALUE = 8.6e-15 DIAGRAM: 2-[1]-139-[2]-85 [1] 2.7e-13 MDLQGKNVWVTGASCGIG ++++++++++++ + +++ 1 MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEEIKKVGGEAIAVKGDVTVESDVIN [2] 4.0e-10 YCASKWYVRMLTRCMAFE +++++ ++ ++++++++ 151 KIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPEQRADVESMIPMGYIGEPEE RFBB_NEIGO no comment LENGTH = 346 COMBINED P-VALUE = 5.54e-16 E-VALUE = 1.8e-14 DIAGRAM: 1-[1]-145-[2]-164 [1] 6.2e-11 MDLQGKNVWVTGASCGIG ++ ++++++++++++ ++ 1 MQTEGKKNILVTGGAGFIGSAVVRHIIQNTRDSVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICDRAELDRVF [2] 2.1e-12 YCASKWYVRMLTRCMAFE +++++++ ++++++++++ 151 DLFTETTPYAPSSPYSASKAAADHLVRAWQRTYRLPSIVSNCSNNYGPRQFPEKLIPLMILNALSGKPLPVYGDG BDH_HUMAN D-BETA-HYDROXYBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.30) (BDH) (3-HYDROXYBUTYRATE DEHYDROGENASE) (FRAGMENT) LENGTH = 343 COMBINED P-VALUE = 2.81e-15 E-VALUE = 9.3e-14 DIAGRAM: 50-[1]-139-[2]-118 [1] 2.0e-11 MDLQGKNVWVTGASCGIG ++++++++++++++++++ 1 GLRPPPPGRFSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHL [2] 3.5e-11 YCASKWYVRMLTRCMAFE ++ +++++++++++++++ 151 GEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYE FIXR_BRAJA FIXR PROTEIN LENGTH = 278 COMBINED P-VALUE = 6.63e-15 E-VALUE = 2.2e-13 DIAGRAM: 31-[1]-139-[2]-72 [1] 1.5e-10 MDLQGKNVWVTGASCGIG ++ ++++++ ++++++++ 1 MGLDLPNDNLIRGPLPEAHLDRLVDAVNARVDRGEPKVMLLTGASRGIGHATAKLFSEAGWRIISCARQPFDGER [2] 1.7e-11 YCASKWYVRMLTRCMAFE ++ ++++++++++ ++++ 151 APILLAQGLFDELRAASGSIVNVTSIAGSRVHPFAGSAYATSKAALASLTRELAHDYAPHGIRVNAIAPGEIRTD BUDC_KLETE ACETOIN(DIACETYL) REDUCTASE (EC 1.1.1.5) (ACETOIN DEHYDROGENASE) LENGTH = 241 COMBINED P-VALUE = 4.85e-14 E-VALUE = 1.6e-12 DIAGRAM: 74-[1]-53-[2]-4-[1]-56 [ 2 M + 1 MQKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATATAVAAEINQAGGRAVAIKVDVSRRDQVFAAVEQARK 1] [2] .6e-05 9.5e- DLQGKNVWVTGASCGIG YCASK +++ +++++ ++ ++ 76 ALGGFNVIVNNAGIAPSTPIESITEEIVDRVYNINVKGVIWGMQAAVEAFKKEGHGGKIVNACSQAGHVGNPELA [1] 05 1.3e-08 WYVRMLTRCMAFE MDLQGKNVWVTGASCGIG ++++++ + +++ +++ ++ + +++ ++++ 151 VYSSSKFAVRGLTQTAARDLAPLGITVNGFCPGIVKTPMWAEIDRQCRKRRANRWATARLNLPNASPLAACRSLK DHES_HUMAN ESTRADIOL 17 BETA-DEHYDROGENASE (EC 1.1.1.62) (20 ALPHA-HYDROXYSTEROID DEHYDROGENASE) (E2DH) (17-BETA-HSD) (PLACENTAL 17-BETA-HYDROXYSTEROID DEHYDROGENASE) LENGTH = 327 COMBINED P-VALUE = 2.63e-13 E-VALUE = 8.7e-12 DIAGRAM: 129-[1]-7-[2]-155 [1] 8.6e-09 MDLQGKNVWVTGASCGIG ++ ++ ++++++ +++ 76 RERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLP [2] 9.5e-12 YCASKWYVRMLTRCMAFE +++++++++++++++++ 151 FNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQV LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC -.-.-.-) LENGTH = 305 COMBINED P-VALUE = 3.13e-13 E-VALUE = 1e-11 DIAGRAM: 1-[1]-137-[2]-131 [1] 3.2e-11 MDLQGKNVWVTGASCGIG ++++++++ +++++++ + 1 MKDFQDQVAFITGGASGAGFGQAKVFGQAGAKIVVADVRAEAVEKAVAELEGLGITAHGIVLDIMDREAYARAAD [2] 3.5e-09 YCASKWYVRMLTRCMAFE ++++++++ ++++ +++ 151 SALAGPYSAAKAASINLMEGYRQGLEKYGIGVSVCTPANIKSNIAEASRLRPAKYGTSGYVENEESIASLHSIHQ PCR_PEA no comment LENGTH = 399 COMBINED P-VALUE = 8.28e-13 E-VALUE = 2.7e-11 DIAGRAM: 81-[1]-168-[2]-114 [1] 8.6e-13 MDLQGKNVWVTGASCGIG +++++ ++++++++++++ 76 SSSEGKKTLRKGNVVITGASSGLGLATAKALAESGKWHVIMACRDYLKAARAAKSAGLAKENYTIMHLDLASLDS [2] 2.0e-07 YCASKWYVRMLTRCMAFE + ++++ +++++++ ++ 226 SITGNTNTLAGNVPPKANLGDLRGLAGGLTGLNSSAMIDGGDFDGAKAYKDSKVCNMLTMQEFHRRYHEETGITF YURA_MYXXA no comment LENGTH = 258 COMBINED P-VALUE = 2.39e-12 E-VALUE = 7.9e-11 DIAGRAM: 153-[2]-4-[1]-65 [2] [1] 6.4e-05 1.8e-08 YCASKWYVRMLTRCMAFE MDLQGKNVWVTGASCGIG + ++++++ + ++ ++++ +++++ ++++ 151 GFRGLPATRYSASKAFLSTFMESLRVDLRGTGVRVTCIYPGFVKSELTATNNFPMPFLMETHDAVELMGKGIVRG HMTR_LEIMA no comment LENGTH = 287 COMBINED P-VALUE = 5.18e-12 E-VALUE = 1.7e-10 DIAGRAM: 1-[1]-11-[2]-144-[2]-77 [1] [2] 1.2e-05 1.1e-07 MDLQGKNVWVTGASCGIG YCASKWYVRMLTRCMAFE + +++++++++ ++ ++ + +++++ +++ +++ 1 MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVS [2] 3.6e-10 YCASKWYVRMLTRCMAFE +++++ ++++++++ +++ 151 PYFLIKAFAHRSRHPSQASRTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGL GUTD_ECOLI SORBITOL-6-PHOSPHATE 2-DEHYDROGENASE (EC 1.1.1.140) (GLUCITOL-6- PHOSPHATE DEHYDROGENASE) (KETOSEPHOSPHATE REDUCTASE) LENGTH = 259 COMBINED P-VALUE = 2.74e-10 E-VALUE = 9e-09 DIAGRAM: 129-[1]-6-[2]-88 [1] 1.2e-06 MDLQGKNVWVTGASCGIG + ++++ ++++ +++++ 76 DEIFGRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKH [2] 1.4e-10 YCASKWYVRMLTRCMAFE +++++++ +++++++++ 151 NSGYSAAKFGGVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLGIKPDQVEQYYIDKVPLKRGC BA72_EUBSP 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (EC 1.1.1.159) (BILE ACID 7-DEHYDROXYLASE) (BILE ACID-INDUCIBLE PROTEIN) LENGTH = 249 COMBINED P-VALUE = 4.05e-10 E-VALUE = 1.3e-08 DIAGRAM: 1-[1]-[2]-119-[2]-75 [1] [2] 3.5e-08 1.4e-07 MDLQGKNVWVTGASCGIGYCASKWYVRMLTRCMAFE + +++++ +++++ ++++++++++++++ +++ + 1 MNLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSRDAVMAA [2] 8.4e-09 YCASKWYVRMLTRCMAFE ++++++ + ++++ ++++ 151 SLSGVGYPASKASVIGLTHGLGREIIRKNIRVVGVAPGVVNTDMTNGNPPEIMEGYLKALPMKRMLEPEEIANVY CSGA_MYXXA no comment LENGTH = 166 COMBINED P-VALUE = 8.98e-10 E-VALUE = 3e-08 DIAGRAM: 12-[1]-57-[2]-61 [1] 1.0e-06 MDLQGKNVWVTGASCGIG ++ ++ + + ++ ++ 1 MRAFATNVCTGPVDVLINNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLPGLRQGALRRVAHVTSRMG [2] 1.5e-09 YCASKWYVRMLTRCMAFE + ++++++ + ++++ ++ 76 SLAANTDGGAYAYRMSKAALNMAVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNP FABI_ECOLI no comment LENGTH = 262 COMBINED P-VALUE = 9.49e-10 E-VALUE = 3.1e-08 DIAGRAM: 1-[1]-2-[2]-223 [1] [2] 3.0e-10 2.1e-06 MDLQGKNVWVTGASCGIG YCASKWYVRMLTRCMAFE ++++++++++ ++++ ++ ++++++ +++ ++ 1 MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMF ADH_DROME ALCOHOL DEHYDROGENASE (EC 1.1.1.1) LENGTH = 255 COMBINED P-VALUE = 1.81e-09 E-VALUE = 6e-08 DIAGRAM: 1-[1]-132-[2]-86 [1] 8.0e-09 MDLQGKNVWVTGASCGIG +++++++++ + ++++ 1 SFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYPYDVTVPIAETTKL [2] 1.6e-07 YCASKWYVRMLTRCMAFE ++ +++++ +++ +++ 151 VYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKA DHCA_HUMAN no comment LENGTH = 276 COMBINED P-VALUE = 2.74e-08 E-VALUE = 9e-07 DIAGRAM: 77-[1]-97-[2]-2-[1]-46 [1] 5.2e-07 MDLQGKNVWVTGASCGIG ++ +++ ++++ ++ + 76 LRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCS [2] [1] 3.6e-08 5.5e-05 YCASKWYVRMLTRCMAFE MDLQGKNVWVTGA ++ ++++++ +++ +++ + ++ +++ + + 151 PELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNAC SCGIG +++ 226 CPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW MAS1_AGRRA no comment LENGTH = 476 COMBINED P-VALUE = 1.17e-07 E-VALUE = 3.9e-06 DIAGRAM: 162-[2]-60-[1]-42-[1]-73-[2]-67 [2] 8.0e-07 YCASKWYVRMLTRCMAFE ++ +++ +++ ++ ++ 151 LKERDFGKHEGGYGPLKMFEDNYPDCEDTEMFSLRVAKALTHAKNENTLFVSHGGVLRVIAALLGVDLTKEHTNN [1] 2.2e-06 MDLQGKNVWVTGASCGIG + +++ ++++ + ++++ 226 GRVLHFRRGFSHWTVEIHQSPVILVSGSNRGVGKAIAEDLIAHGYRLSLGARKVKDLEVAFGPQDEWLHYARFDA [1] 3.5e-08 MDLQGKNVWVTGASCGIG ++++ ++++++ + +++ 301 EDHGTMAAWVTAAVEKFGRIDGLVNNAGYGEPVNLDKHVDYQRFHLQWYINCVAPLRMTELCLPHLYETGSGRIV [2] 2.1e-06 YCASKWYVRMLTRCMAFE + ++++++ ++++++++ 376 NINSMSGQRVLNPLVGYNMTKHALGGLTKTTQHVGWDRRCAAIDICLGFVATDMSAWTDLIASKDMIQPEDIAKL ******************************************************************************** CPU: Timothys-iMac.rd.unr.edu Time 0.018 secs. mast -oc results/mast23 -nostatus meme/meme.adh.de.oops.xml common/adh.s