LOCUS       NP_034640                182 aa            linear   ROD 15-NOV-2007
DEFINITION  interferon beta 1, fibroblast precursor [Mus musculus].
ACCESSION   NP_034640
VERSION     NP_034640.1  GI:6754304
DBSOURCE    REFSEQ: accession NM_010510.1
KEYWORDS    .
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE   1  (residues 1 to 182)
  AUTHORS   Schroder,K., Spille,M., Pilz,A., Lattin,J., Bode,K.A., Irvine,K.M.,
            Burrows,A.D., Ravasi,T., Weighardt,H., Stacey,K.J., Decker,T.,
            Hume,D.A., Dalpke,A.H. and Sweet,M.J.
  TITLE     Differential effects of CpG DNA on IFN-beta induction and STAT1
            activation in murine macrophages versus dendritic cells:
            alternatively activated STAT1 negatively regulates TLR signaling in
            macrophages
  JOURNAL   J. Immunol. 179 (6), 3495-3503 (2007)
   PUBMED   17785783
  REMARK    GeneRIF: The interferon-beta/STAT1 axis is a key regulator of CpG
            DNA signaling; divergent activation of this pathway between bone
            marrow-derived macrophages and myeloid dendritic cells dictates
            cell-specific immune responses.
REFERENCE   2  (residues 1 to 182)
  AUTHORS   Wang,Y.X., da Cunha,V., Vincelette,J., White,K., Velichko,S.,
            Xu,Y., Gross,C., Fitch,R.M., Halks-Miller,M., Larsen,B.R.,
            Yajima,T., Knowlton,K.U., Vergona,R., Sullivan,M.E. and Croze,E.
  TITLE     Antiviral and myocyte protective effects of murine interferon-beta
            and -{alpha}2 in coxsackievirus B3-induced myocarditis and
            epicarditis in Balb/c mice
  JOURNAL   Am. J. Physiol. Heart Circ. Physiol. 293 (1), H69-H76 (2007)
   PUBMED   17434974
  REMARK    GeneRIF: These data demonstrate antiviral effects for both
            mIFN-beta and mIFN-alpha(2), which lead to protection of the mice
            from CVB3-induced myocarditis.
REFERENCE   3  (residues 1 to 182)
  AUTHORS   Chang,E.Y., Guo,B., Doyle,S.E. and Cheng,G.
  TITLE     Cutting edge: involvement of the type I IFN production and
            signaling pathway in lipopolysaccharide-induced IL-10 production
  JOURNAL   J. Immunol. 178 (11), 6705-6709 (2007)
   PUBMED   17513714
  REMARK    GeneRIF: Type I interferon production and signaling pathway play a
            role in regulating the lipopolysaccharide response in bone
            marrow-derived macrophages.
REFERENCE   4  (residues 1 to 182)
  AUTHORS   Meissner,N., Rutkowski,M., Harmsen,A.L., Han,S. and Harmsen,A.G.
  TITLE     Type I interferon signaling and B cells maintain hemopoiesis during
            Pneumocystis infection of the lung
  JOURNAL   J. Immunol. 178 (10), 6604-6615 (2007)
   PUBMED   17475892
  REMARK    GeneRIF: Both interferon-beta and -alpha genes are required in the
            regenerative capabilities of the hemopoietic system under the
            pressure of Pneumocystis infection.
REFERENCE   5  (residues 1 to 182)
  AUTHORS   Henry,T., Brotcke,A., Weiss,D.S., Thompson,L.J. and Monack,D.M.
  TITLE     Type I interferon signaling is required for activation of the
            inflammasome during Francisella infection
  JOURNAL   J. Exp. Med. 204 (5), 987-994 (2007)
   PUBMED   17452523
REFERENCE   6  (residues 1 to 182)
  AUTHORS   Senda,T., Shimazu,T., Matsuda,S., Kawano,G., Shimizu,H.,
            Nakamura,K.T. and Mitsui,Y.
  TITLE     Three-dimensional crystal structure of recombinant murine
            interferon-beta
  JOURNAL   EMBO J. 11 (9), 3193-3201 (1992)
   PUBMED   1505514
REFERENCE   7  (residues 1 to 182)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm. Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   8  (residues 1 to 182)
  AUTHORS   Tanaka,N. and Taniguchi,T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv. Immunol. 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   9  (residues 1 to 182)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm. Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (residues 1 to 182)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
COMMENT     VALIDATED REFSEQ: This record has undergone preliminary review of
            the sequence, but has not yet been subject to final review. The
            reference sequence was derived from K00020.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..182
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.6 cM"
     Protein         1..182
                     /product="interferon beta 1, fibroblast precursor"
     sig_peptide     1..21
                     /note="ifn-beta"
                     /calculated_mol_wt=2410
     mat_peptide     22..182
                     /product="ifn-beta"
                     /calculated_mol_wt=19735
     Region          27..173
                     /region_name="IFab"
                     /note="Interferon alpha, beta. Includes also interferon
                     omega and tau. Different from interferon gamma family;
                     cd00095"
                     /db_xref="CDD:28979"
     Site            order(29..30,33,36..37,40,43..44,96..97,99..100,102..103,
                     106,109..110,113..114,117)
                     /site_type="other"
                     /note="putative IFNAR-1 binding site"
                     /db_xref="CDD:28979"
     Site            order(51..58,60..62,66..67,136..137,139..140,143..144,
                     146..147,150..155)
                     /site_type="other"
                     /note="putative IFNAR-2 binding site"
                     /db_xref="CDD:28979"
     Site            97
                     /site_type="other"
                     /note="N-glycosylation site"
                     /db_xref="CDD:28979"
     CDS             1..182
                     /gene="Ifnb1"
                     /coded_by="NM_010510.1:21..569"
                     /GO_component="extracellular region"
                     /GO_function="cytokine activity;
                     hematopoietin/interferon-class (D200-domain) cytokine
                     receptor binding"
                     /GO_process="defense response; defense response to
                     bacterium; response to virus"
                     /db_xref="CCDS:CCDS18318.1"
                     /db_xref="GeneID:15977"
                     /db_xref="MGI:107657"
ORIGIN      
        1 mnnrwilhaa fllcfsttal sinykqlqlq ertnirkcqe lleqlngkin ltyradfkip
       61 memtekmqks ytafaiqeml qnvflvfrnn fsstgwneti vvrlldelhq qtvflktvle
      121 ekqeerltwe msstalhlks yywrvqrylk lmkynsyawm vvraeifrnf liirrltrnf
      181 qn
//

