2329-4302 5 2 2018 Apr J Med Imaging (Bellingham) Development of a pulmonary imaging biomarker pipeline for phenotyping of chronic lung disease. 026002 10.1117/1.JMI.5.2.026002 We designed and generated pulmonary imaging biomarker pipelines to facilitate high-throughput research and point-of-care use in patients with chronic lung disease. Image processing modules and algorithm pipelines were embedded within a graphical user interface (based on the .NET framework) for pulmonary magnetic resonance imaging (MRI) and x-ray computed-tomography (CT) datasets. The software pipelines were generated using C++ and included: (1) inhaled He 3 / Xe 129   MRI ventilation and apparent diffusion coefficients, (2) CT-MRI coregistration for lobar and segmental ventilation and perfusion measurements, (3) ultrashort echo-time H 1   MRI proton density measurements, (4) free-breathing Fourier-decomposition H 1   MRI ventilation/perfusion and free-breathing H 1   MRI specific ventilation, (5) multivolume CT and MRI parametric response maps, and (6) MRI and CT texture analysis and radiomics. The image analysis framework was implemented on a desktop workstation/tablet to generate biomarkers of regional lung structure and function related to ventilation, perfusion, lung tissue texture, and integrity as well as multiparametric measures of gas trapping and airspace enlargement. All biomarkers were generated within 10 min with measurement reproducibility consistent with clinical and research requirements. The resultant pulmonary imaging biomarker pipeline provides real-time and automated lung imaging measurements for point-of-care and high-throughput research. Guo Fumin F University of Western Ontario, Robarts Research Institute, London, Ontario, Canada. University of Western Ontario, Graduate Program in Biomedical Engineering, London, Ontario, Canada. University of Toronto, Sunnybrook Research Institute, Toronto, Canada. Capaldi Dante D https://orcid.org/0000-0002-4590-7461 University of Western Ontario, Robarts Research Institute, London, Ontario, Canada. University of Western Ontario, Department of Medical Biophysics, London, Ontario, Canada. Kirby Miranda M University of British Columbia, St. Paul's Hospital, Centre for Heart Lung Innovation, Vancouver, Canada. Sheikh Khadija K University of Western Ontario, Robarts Research Institute, London, Ontario, Canada. Svenningsen Sarah S University of Western Ontario, Robarts Research Institute, London, Ontario, Canada. McCormack David G DG University of Western Ontario, Division of Respirology, Department of Medicine, London, Ontario, Canada. Fenster Aaron A https://orcid.org/0000-0003-3525-2788 University of Western Ontario, Robarts Research Institute, London, Ontario, Canada. University of Western Ontario, Graduate Program in Biomedical Engineering, London, Ontario, Canada. University of Western Ontario, Department of Medical Biophysics, London, Ontario, Canada. Parraga Grace G University of Western Ontario, Robarts Research Institute, London, Ontario, Canada. University of Western Ontario, Graduate Program in Biomedical Engineering, London, Ontario, Canada. University of Western Ontario, Department of Medical Biophysics, London, Ontario, Canada. Canadian Respiratory Research Network eng Journal Article 2018 06 28