1664-042X 9 2018 Front Physiol A "Blood Relationship" Between the Overlooked Minimum Lactate Equivalent and Maximal Lactate Steady State in Trained Runners. Back to the Old Days? 1034 10.3389/fphys.2018.01034 Maximal Lactate Steady State (MLSS) and Lactate Threshold (LT) are physiologically-related and fundamental concepts within the sports and exercise sciences. Literature supporting their relationship, however, is scarce. Among the recognized LTs, we were particularly interested in the disused "Minimum Lactate Equivalent" (LE_min), first described in the early 1980s. We hypothesized that velocity at LT, conceptually comprehended as in the old days (LE_min), could predict velocity at MLSS (_VMLSS) more accurate than some other blood lactate-related thresholds (BL_RTs) routinely used nowadays by many sport science practitioners. Thirteen male endurance-trained [_VMLSS 15.0 ± 1.1 km·h^-1; maximal oxygen uptake ( V . O 2 m a x ) 67.6 ± 4.1 ml·kg^-1·min^-1] homogeneous (coefficient of variation: ≈7%) runners conducted 1) a submaximal discontinuous incremental running test to determine several BL_RTs followed by a maximal ramp incremental running test for V . O 2 m a x   determination, and 2) several (4-5) constant velocity running tests to determine _VMLSS with a precision of 0.20 km·h^-1. Determined BL_RTs include LE_min and LE_min-related LE_min plus 1 (LE_min+1mM) and 1.5 mmol·L^-1 (LE_min+1.5mM), along with well-established BL_RTs such as conventionally-calculated LT, D_max and fixed blood lactate concentration thresholds. LE_min did not differ from LT (P = 0.71; ES: 0.08) and was 27% lower than MLSS (P < 0.001; ES: 3.54). LE_min+1mM was not different from MLSS (P = 0.47; ES: 0.09). LE_min was the best predictor of _VMLSS (r = 0.91; P < 0.001; SEE = 0.47 km·h^-1), followed by LE_min+1mM (r = 0.86; P < 0.001; SEE = 0.58 km·h^-1) and LE_min+1.5mM (r = 0.84; P < 0.001; SEE = 0.86 km·h^-1). There was no statistical difference between MLSS and estimated MLSS using LE_min prediction formula (P = 0.99; ES: 0.001). Mean bias and limits of agreement were 0.00 ± 0.45 km·h^-1 and ±0.89 km·h^-1. Additionally, LE_min, LE_min+1mM and LE_min+1.5mM were the best predictors of V . O 2 m a x (r = 0.72-0.79; P < 0.001). These results support LE_min, an objective submaximal overlooked and underused BL_RT, to be one of the best single MLSS predictors in endurance trained runners. Our study advocates factors controlling LE_min to be shared, at least partly, with those controlling MLSS. Garcia-Tabar Ibai I Studies, Research and Sports Medicine Center, Government of Navarre, Pamplona, Spain. Gorostiaga Esteban M EM Studies, Research and Sports Medicine Center, Government of Navarre, Pamplona, Spain. eng Journal Article 2018 07 31