601100 1 STRESS 70 PROTEIN CHAPERONE, MICROSOME-ASSOCIATED, 60-KD; STCH Copyright (c) 1966-2008 Johns Hopkins University STCH 21q11.1 TEXT The stress-70 chaperone family consists of proteins that bind to denatured or incorrectly folded polypeptides and play a major role in the processing of cytosolic and secretory proteins. {2:Otterson et al. (1994)} cloned a human cDNA encoding a predicted 471-amino acid protein (60 kD) which they designated STCH. {1:Brodsky et al. (1995)} stated that the protein sequence is very similar to that of HSP70 ({140550}) and BiP ({138120}). As with other members of the family, the STCH protein contains an ATPase domain at the amino terminus whose activity was shown to be independent of peptide stimulation. The protein was found to be microsome-associated and constitutively expressed in all cell types examined. 30 8131751,9358068,10675567,9488737,8757872,11048651,2559088,10982831,2105497,16572726,9083109,17181539,14508011,15028727,10651811,9108392,11599566,2661019,11836248,7594475,12406544,8536694,12389629,10430932,9177027,9837933,8522346,2928112,12834280,8702658 0 TEXT {1:Brodsky et al. (1995)} mapped the STCH gene to chromosome 21q11.1 with a high-resolution somatic cell hybrid panel for chromosome 21 and by fluorescence in situ hybridization with a YAC containing the gene. By interspecific backcross analysis, {3:Reeves et al. (1998)} mapped the mouse Stch gene to chromosome 16. 30 1354597,8244375,8597637,8838809,9143508,1427875,7806216,9852683,7835904,11060461,10083745,7789175,7806232,7513297,8020937,12014109,1769649,2045096,9747039,8034329,8088815,1783375,8275716,8020959,7956352,8020952,10198174,7655454,8750197,11272792 0 terry 1999 3 9 carol 1999 3 7 carol 1998 7 8 terry 1996 5 24 mark 1996 3 1 mark 1996 3 1 Alan F. Scott 1996 3 1 1 1 Brodsky, G. 1 Otterson, G. A. 1 Parry, B. B. 1 Hart, I. 1 Patterson, D. 1 Kaye, F. J. 1 Brodsky et al. Localization of STCH to human chromosome 21q11.1. 0 30 Genomics 1995 0 0 627 628 8825657 2 2 Otterson, G. A. 1 Flynn, G. C. 1 Kratzke, R. A. 1 Coxon, A. 1 Johnston, P. G. 1 Kaye, F. J. 1 Otterson et al. Stch encodes the 'ATPase core' of a microsomal stress70 protein. 0 13 EMBO J. 1994 0 0 1216 1225 8131751 3 3 Reeves, R. H. 1 Rue, E. 1 Yu, J. 1 Kao, F.-T. 1 Reeves et al. Stch maps to mouse chromosome 16, extending the conserved synteny with human chromosome 21. 0 49 Genomics 1998 0 0 156 157 9570963 Carol A. Bocchini - updated 1999 3 7 1 3 8825657,8131751,9570963 0 7 148747550,67461586,48928056,30089677,2352621,1351125,460148 0 5 148747549,55741785,48928055,2352620,460147 0