<!-- ============================================
     ::DATATOOL:: Generated from "docsum.asn"
     ::DATATOOL:: by application DATATOOL version 1.9.2
     ::DATATOOL:: on 05/06/2009 23:05:17
     ============================================ -->

<!-- ============================================ -->
<!-- This section is mapped from module "Docsum-3-1"
================================================= -->

<!--
 ============================================
 ::DATATOOL:: Generated from "docsum_3.1.xsd"
 ::DATATOOL:: by application DATATOOL version 1.8.6
 ::DATATOOL:: on 05/05/2009 10:27:19
 ============================================
 edited with XMLSPY v5 rel. 4 U (http://www.xmlspy.com) by Michael Kholodov (National Library of Medicine) 
 edited with XMLSpy v2005 rel. 3 U (http://www.altova.com) by Michael Feolo (NCBI/NLM/NIH) 
-->


<!ELEMENT Assay (
        Assay_attlist, 
        Assay_method, 
        Assay_taxonomy, 
        Assay_strains?, 
        Assay_comment?, 
        Assay_citation?)>

<!ELEMENT Assay_attlist (
        Assay_attlist_handle?, 
        Assay_attlist_batch?, 
        Assay_attlist_batchId?, 
        Assay_attlist_batchType?, 
        Assay_attlist_molType?, 
        Assay_attlist_sampleSize?, 
        Assay_attlist_population?, 
        Assay_attlist_linkoutUrl?)>

<!ELEMENT Assay_attlist_handle (#PCDATA)>

<!ELEMENT Assay_attlist_batch (#PCDATA)>

<!ELEMENT Assay_attlist_batchId (%INTEGER;)>

<!ELEMENT Assay_attlist_batchType %ENUM;>
<!ATTLIST Assay_attlist_batchType value (
        snpassay |
        validation |
        doublehit
        ) #REQUIRED >


<!ELEMENT Assay_attlist_molType %ENUM;>
<!ATTLIST Assay_attlist_molType value (
        genomic |
        cDNA |
        mito |
        chloro
        ) #REQUIRED >


<!ELEMENT Assay_attlist_sampleSize (%INTEGER;)>

<!ELEMENT Assay_attlist_population (#PCDATA)>

<!ELEMENT Assay_attlist_linkoutUrl (#PCDATA)>

<!ELEMENT Assay_method (
        Assay_method_eMethod?)>

<!ELEMENT Assay_method_eMethod (
        Assay_method_eMethod_attlist, 
        Assay_method_eMethod_exception)>

<!ELEMENT Assay_method_eMethod_attlist (
        Assay_method_eMethod_attlist_name?, 
        Assay_method_eMethod_attlist_id?)>

<!--Submitters method identifier -->
<!ELEMENT Assay_method_eMethod_attlist_name (#PCDATA)>

<!--dbSNP method identifier -->
<!ELEMENT Assay_method_eMethod_attlist_id (#PCDATA)>

<!--description of deviation from/addition to given method -->
<!ELEMENT Assay_method_eMethod_exception (#PCDATA)>

<!ELEMENT Assay_taxonomy (
        Assay_taxonomy_attlist, 
        Assay_taxonomy_taxonomy)>

<!ELEMENT Assay_taxonomy_attlist (
        Assay_taxonomy_attlist_id, 
        Assay_taxonomy_attlist_organism?)>

<!--NCBI taxonomy ID for variation -->
<!ELEMENT Assay_taxonomy_attlist_id (%INTEGER;)>

<!ELEMENT Assay_taxonomy_attlist_organism (#PCDATA)>

<!ELEMENT Assay_taxonomy_taxonomy EMPTY>

<!ELEMENT Assay_strains (Assay_strains_E*)>


<!ELEMENT Assay_strains_E (#PCDATA)>

<!ELEMENT Assay_comment (#PCDATA)>

<!ELEMENT Assay_citation (Assay_citation_E*)>


<!ELEMENT Assay_citation_E (#PCDATA)>

<!--A collection of genome sequence records (curated gene regions (NG's), contigs (NWNT's)  and chromosomes (NC/AC's) produced by a genome sequence project. Structure is populated from ContigInfo tables. -->
<!ELEMENT Assembly (
        Assembly_attlist, 
        Assembly_component?, 
        Assembly_snpStat)>

<!ELEMENT Assembly_attlist (
        Assembly_attlist_dbSnpBuild, 
        Assembly_attlist_genomeBuild, 
        Assembly_attlist_groupLabel?, 
        Assembly_attlist_assemblySource?, 
        Assembly_attlist_current?, 
        Assembly_attlist_reference?)>

<!--dbSNP build number defining the rsid set aligned to this assembly -->
<!ELEMENT Assembly_attlist_dbSnpBuild (%INTEGER;)>

<!--assembly build number with possible 'subbuild' version numbers to reflect updates in gene annotation (human e.g. 34_3, 35_1, 36_1) -->
<!ELEMENT Assembly_attlist_genomeBuild (#PCDATA)>

<!--High-level classification of the assembly to distinguish reference projects from alternate solutions. GroupLabel field from organism/build-specific ContigInfo tables. "reference" is occasionally used as the preferred assembly; standards will converge as additional organism genome projects are finished. Note that some organism assembly names include extended characters like '~' and '/' that may be incompatible with OS filename conventions. -->
<!ELEMENT Assembly_attlist_groupLabel (#PCDATA)>

<!--Name of the group(s) or organization(s) that generated the assembly -->
<!ELEMENT Assembly_attlist_assemblySource (#PCDATA)>

<!--Marks the current genomic assembly -->
<!ELEMENT Assembly_attlist_current EMPTY>
<!ATTLIST Assembly_attlist_current value ( true | false ) #REQUIRED >


<!ELEMENT Assembly_attlist_reference EMPTY>
<!ATTLIST Assembly_attlist_reference value ( true | false ) #REQUIRED >


<!ELEMENT Assembly_component (Component*)>

<!ELEMENT Assembly_snpStat (
        Assembly_snpStat_attlist, 
        Assembly_snpStat_snpStat)>

<!ELEMENT Assembly_snpStat_attlist (
        Assembly_snpStat_attlist_mapWeight, 
        Assembly_snpStat_attlist_chromCount?, 
        Assembly_snpStat_attlist_placedContigCount?, 
        Assembly_snpStat_attlist_unplacedContigCount?, 
        Assembly_snpStat_attlist_seqlocCount?, 
        Assembly_snpStat_attlist_hapCount?)>

<!--summary measure of placement precision in the assembly -->
<!ELEMENT Assembly_snpStat_attlist_mapWeight %ENUM;>
<!ATTLIST Assembly_snpStat_attlist_mapWeight value (
        unmapped |
        unique-in-contig |
        two-hits-in-contig |
        less-10-hits |
        multiple-hits
        ) #REQUIRED >


<!--number of distinct chromosomes in the mapset -->
<!ELEMENT Assembly_snpStat_attlist_chromCount (%INTEGER;)>

<!--number of distinct contigs [ gi | accession[.version] ] in the mapset -->
<!ELEMENT Assembly_snpStat_attlist_placedContigCount (%INTEGER;)>

<!--number of sequence postions to a contig with unknown chromosomal assignment -->
<!ELEMENT Assembly_snpStat_attlist_unplacedContigCount (%INTEGER;)>

<!--total number of sequence positions in the mapset -->
<!ELEMENT Assembly_snpStat_attlist_seqlocCount (%INTEGER;)>

<!--Number of hits to alternative genomic haplotypes (e.g. HLA DR region, KIR, or pseudo-autosomal regions like PAR) within the assembly mapset. Note that positions on haplotypes defined in other assemblies (a different assembly_group_label value) will not be counted in this value. -->
<!ELEMENT Assembly_snpStat_attlist_hapCount (%INTEGER;)>

<!ELEMENT Assembly_snpStat_snpStat EMPTY>

<!--URL value from dbSNP_main.BaseURL links table. attributes provide context information and URL id that is referenced within individual refSNP objects. -->
<!ELEMENT BaseURL (
        BaseURL_attlist, 
        BaseURL_baseURL)>

<!ELEMENT BaseURL_attlist (
        BaseURL_attlist_urlId?, 
        BaseURL_attlist_resourceName?, 
        BaseURL_attlist_resourceId?)>

<!--Resource identifier from dbSNP_main.baseURL. -->
<!ELEMENT BaseURL_attlist_urlId (%INTEGER;)>

<!--Name of linked resource -->
<!ELEMENT BaseURL_attlist_resourceName (#PCDATA)>

<!--identifier expected by resource for URL -->
<!ELEMENT BaseURL_attlist_resourceId (#PCDATA)>

<!--URL value from dbSNP_main.BaseURL links table. attributes provide context information and URL id that is referenced within individual refSNP objects. -->
<!ELEMENT BaseURL_baseURL (#PCDATA)>


<!ELEMENT Component (
        Component_attlist, 
        Component_mapLoc)>

<!ELEMENT Component_attlist (
        Component_attlist_componentType?, 
        Component_attlist_ctgId?, 
        Component_attlist_accession?, 
        Component_attlist_name?, 
        Component_attlist_chromosome?, 
        Component_attlist_start?, 
        Component_attlist_end?, 
        Component_attlist_orientation?, 
        Component_attlist_gi?, 
        Component_attlist_groupTerm?, 
        Component_attlist_contigLabel?)>

<!--type of component: chromosome, contig, gene_region, etc. -->
<!ELEMENT Component_attlist_componentType %ENUM;>
<!ATTLIST Component_attlist_componentType value (
        contig |
        mrna
        ) #REQUIRED >


<!--dbSNP contig_id used to join on contig hit / mapset data to these assembly properties -->
<!ELEMENT Component_attlist_ctgId (%INTEGER;)>

<!--Accession[.version] for the sequence component -->
<!ELEMENT Component_attlist_accession (#PCDATA)>

<!--contig name defined as either a submitter local id, element of a whole genome assembly set, or internal NCBI local id -->
<!ELEMENT Component_attlist_name (#PCDATA)>

<!--Organism appropriate chromosome tag, 'Un' reserved for default case of unplaced components -->
<!ELEMENT Component_attlist_chromosome (#PCDATA)>

<!--component starting position on the chromosome (base 0 inclusive) -->
<!ELEMENT Component_attlist_start (%INTEGER;)>

<!--component ending position on the chromosome (base 0 inclusive) -->
<!ELEMENT Component_attlist_end (%INTEGER;)>

<!--orientation of this component to chromosome, forward (fwd) = 0, reverse (rev) = 1, unknown = NULL in ContigInfo.orient. -->
<!ELEMENT Component_attlist_orientation %ENUM;>
<!ATTLIST Component_attlist_orientation value (
        fwd |
        rev |
        unknown
        ) #REQUIRED >


<!--NCBI gi for component sequence (equivalent to accession.version) for nucleotide sequence. -->
<!ELEMENT Component_attlist_gi (#PCDATA)>

<!--Identifier label for the genome assembly that defines the contigs in this mapset and their placement within the organism genome.  -->
<!ELEMENT Component_attlist_groupTerm (#PCDATA)>

<!--Display label for component -->
<!ELEMENT Component_attlist_contigLabel (#PCDATA)>

<!ELEMENT Component_mapLoc (MapLoc*)>

<!--Set of dbSNP refSNP docsums -->
<!ELEMENT ExchangeSet (
        ExchangeSet_attlist, 
        ExchangeSet_sourceDatabase, 
        ExchangeSet_rs?, 
        ExchangeSet_assay?, 
        ExchangeSet_query?, 
        ExchangeSet_summary, 
        ExchangeSet_baseURL)>

<!ELEMENT ExchangeSet_attlist (
        ExchangeSet_attlist_setType?, 
        ExchangeSet_attlist_setDepth?, 
        ExchangeSet_attlist_specVersion?, 
        ExchangeSet_attlist_dbSnpBuild?, 
        ExchangeSet_attlist_generated?)>

<!--set-type: full dump; from query; single refSNP -->
<!ELEMENT ExchangeSet_attlist_setType (#PCDATA)>

<!--content depth: brief XML (only refSNP properties and summary subSNP element content); full XML (full refSNP, full subSNP content; all flanking sequences) -->
<!ELEMENT ExchangeSet_attlist_setDepth (#PCDATA)>

<!--version number of docsum.asn/docsum.dtd specification -->
<!ELEMENT ExchangeSet_attlist_specVersion (#PCDATA)>

<!--build number of database for this export -->
<!ELEMENT ExchangeSet_attlist_dbSnpBuild (%INTEGER;)>

<!--Generated date -->
<!ELEMENT ExchangeSet_attlist_generated (#PCDATA)>

<!ELEMENT ExchangeSet_sourceDatabase (
        ExchangeSet_sourceDatabase_attlist, 
        ExchangeSet_sourceDatabase_sourceDatabase)>

<!ELEMENT ExchangeSet_sourceDatabase_attlist (
        ExchangeSet_sourceDatabase_attlist_taxId, 
        ExchangeSet_sourceDatabase_attlist_organism, 
        ExchangeSet_sourceDatabase_attlist_dbSnpOrgAbbr?, 
        ExchangeSet_sourceDatabase_attlist_gpipeOrgAbbr?)>

<!--NCBI taxonomy ID for variation -->
<!ELEMENT ExchangeSet_sourceDatabase_attlist_taxId (%INTEGER;)>

<!--common name for species used as part of database name. -->
<!ELEMENT ExchangeSet_sourceDatabase_attlist_organism (#PCDATA)>

<!--organism abbreviation used in dbSNP.  -->
<!ELEMENT ExchangeSet_sourceDatabase_attlist_dbSnpOrgAbbr (#PCDATA)>

<!--organism abbreviation used within NCBI genome pipeline data dumps. -->
<!ELEMENT ExchangeSet_sourceDatabase_attlist_gpipeOrgAbbr (#PCDATA)>

<!ELEMENT ExchangeSet_sourceDatabase_sourceDatabase EMPTY>

<!ELEMENT ExchangeSet_rs (Rs*)>

<!ELEMENT ExchangeSet_assay (Assay)>

<!ELEMENT ExchangeSet_query (
        ExchangeSet_query_attlist, 
        ExchangeSet_query_query)>

<!ELEMENT ExchangeSet_query_attlist (
        ExchangeSet_query_attlist_date?, 
        ExchangeSet_query_attlist_string?)>

<!--yyyy-mm-dd -->
<!ELEMENT ExchangeSet_query_attlist_date (#PCDATA)>

<!--Query terms or search constraints -->
<!ELEMENT ExchangeSet_query_attlist_string (#PCDATA)>

<!ELEMENT ExchangeSet_query_query EMPTY>

<!ELEMENT ExchangeSet_summary (
        ExchangeSet_summary_attlist, 
        ExchangeSet_summary_summary)>

<!ELEMENT ExchangeSet_summary_attlist (
        ExchangeSet_summary_attlist_numRsIds?, 
        ExchangeSet_summary_attlist_totalSeqLength?, 
        ExchangeSet_summary_attlist_numContigHits?, 
        ExchangeSet_summary_attlist_numGeneHits?, 
        ExchangeSet_summary_attlist_numGiHits?, 
        ExchangeSet_summary_attlist_num3dStructs?, 
        ExchangeSet_summary_attlist_numAlleleFreqs?, 
        ExchangeSet_summary_attlist_numStsHits?, 
        ExchangeSet_summary_attlist_numUnigeneCids?)>

<!--Total number of refsnp-ids in this exchange set -->
<!ELEMENT ExchangeSet_summary_attlist_numRsIds (%INTEGER;)>

<!--Total length of exemplar flanking sequences -->
<!ELEMENT ExchangeSet_summary_attlist_totalSeqLength (%INTEGER;)>

<!--Total number of contig locations from SNPContigLoc -->
<!ELEMENT ExchangeSet_summary_attlist_numContigHits (%INTEGER;)>

<!--Total number of locus ids from SNPContigLocusId -->
<!ELEMENT ExchangeSet_summary_attlist_numGeneHits (%INTEGER;)>

<!--Total number of gi hits from MapLink -->
<!ELEMENT ExchangeSet_summary_attlist_numGiHits (%INTEGER;)>

<!--Total number of 3D structures from SNP3D -->
<!ELEMENT ExchangeSet_summary_attlist_num3dStructs (%INTEGER;)>

<!--Total number of allele frequences from SubPopAllele -->
<!ELEMENT ExchangeSet_summary_attlist_numAlleleFreqs (%INTEGER;)>

<!--Total number of STS hits from SnpInSts -->
<!ELEMENT ExchangeSet_summary_attlist_numStsHits (%INTEGER;)>

<!--Total number of unigene cluster ids from UnigeneSnp -->
<!ELEMENT ExchangeSet_summary_attlist_numUnigeneCids (%INTEGER;)>

<!ELEMENT ExchangeSet_summary_summary EMPTY>

<!ELEMENT ExchangeSet_baseURL (BaseURL*)>

<!--functional relationship of SNP (and possibly alleles) to genes at contig location as defined in organism-specific bxxx_SNPContigLocusId_xxx tables. -->
<!ELEMENT FxnSet (
        FxnSet_attlist, 
        FxnSet_fxnSet)>

<!ELEMENT FxnSet_attlist (
        FxnSet_attlist_geneId?, 
        FxnSet_attlist_symbol?, 
        FxnSet_attlist_mrnaAcc?, 
        FxnSet_attlist_mrnaVer?, 
        FxnSet_attlist_protAcc?, 
        FxnSet_attlist_protVer?, 
        FxnSet_attlist_fxnClass?, 
        FxnSet_attlist_readingFrame?, 
        FxnSet_attlist_allele?, 
        FxnSet_attlist_residue?, 
        FxnSet_attlist_aaPosition?)>

<!--gene-id of gene as aligned to contig -->
<!ELEMENT FxnSet_attlist_geneId (%INTEGER;)>

<!--symbol (official if present in Entrez Gene) of gene -->
<!ELEMENT FxnSet_attlist_symbol (#PCDATA)>

<!--mRNA accession if variation in transcript -->
<!ELEMENT FxnSet_attlist_mrnaAcc (#PCDATA)>

<!--mRNA sequence version if variation is in transcripot -->
<!ELEMENT FxnSet_attlist_mrnaVer (%INTEGER;)>

<!--protein accession if variation in protein -->
<!ELEMENT FxnSet_attlist_protAcc (#PCDATA)>

<!--protein version if variation is in protein -->
<!ELEMENT FxnSet_attlist_protVer (%INTEGER;)>
<!--
variation in region of gene, but not in transcript - deprecated
								synonymous change	
								nonsynonymous change - deprecated
								untranslated region - deprecated
								splice-site - deprecated
								contig reference
								deprecated
									coding: synonymy unknown
									In gene segment with null mrna and protein. ex. IGLV4-69. geneId=28784
									within 3' 0.5kb to a gene.
									changes to STOP codon.
									alters codon to make an altered amino acid in protein product.
									indel snp causing frameshift.
									3 prime untranslated region
									5 prime untranslated region
									3 prime acceptor dinucleotide
									5 prime donor dinucleotide
-->
<!ELEMENT FxnSet_attlist_fxnClass %ENUM;>
<!ATTLIST FxnSet_attlist_fxnClass value (
        locus-region |
        coding-unknown |
        coding-synonymous |
        coding-nonsynonymous |
        mrna-utr |
        intron |
        splice-site |
        reference |
        coding-exception |
        synonymy-unknown |
        gene-segment |
        near-gene-3 |
        near-gene-5 |
        nonsense |
        missense |
        frameshift |
        utr-3 |
        utr-5 |
        splice-3 |
        splice-5
        ) #REQUIRED >


<!ELEMENT FxnSet_attlist_readingFrame (%INTEGER;)>

<!--variation allele: * suffix indicates allele of contig at this location -->
<!ELEMENT FxnSet_attlist_allele (#PCDATA)>

<!--translated amino acid residue for allele -->
<!ELEMENT FxnSet_attlist_residue (#PCDATA)>

<!--position of the variant residue in peptide sequence -->
<!ELEMENT FxnSet_attlist_aaPosition (%INTEGER;)>

<!--functional relationship of SNP (and possibly alleles) to genes at contig location as defined in organism-specific bxxx_SNPContigLocusId_xxx tables. -->
<!ELEMENT FxnSet_fxnSet EMPTY>

<!--Position of a single hit of a variation on a contig -->
<!ELEMENT MapLoc (
        MapLoc_attlist, 
        MapLoc_fxnSet?)>

<!ELEMENT MapLoc_attlist (
        MapLoc_attlist_asnFrom, 
        MapLoc_attlist_asnTo, 
        MapLoc_attlist_locType, 
        MapLoc_attlist_alnQuality?, 
        MapLoc_attlist_orient?, 
        MapLoc_attlist_physMapInt?, 
        MapLoc_attlist_leftFlankNeighborPos?, 
        MapLoc_attlist_rightFlankNeighborPos?, 
        MapLoc_attlist_leftContigNeighborPos?, 
        MapLoc_attlist_rightContigNeighborPos?, 
        MapLoc_attlist_numberOfMismatches?, 
        MapLoc_attlist_numberOfDeletions?, 
        MapLoc_attlist_numberOfInsertions?)>

<!--beginning of variation as feature on contig -->
<!ELEMENT MapLoc_attlist_asnFrom (%INTEGER;)>

<!--end position of variation as feature on contig -->
<!ELEMENT MapLoc_attlist_asnTo (%INTEGER;)>
<!--
defines the seq-loc symbol if asn_from != asn_to
insertion on contig
asn-from = asn-to write as 'asn-from'
deletion on contig
-->
<!ELEMENT MapLoc_attlist_locType %ENUM;>
<!ATTLIST MapLoc_attlist_locType value (
        insertion |
        exact |
        deletion |
        range-ins |
        range-exact |
        range-del
        ) #REQUIRED >


<!--alignment qualiity -->
<!ELEMENT MapLoc_attlist_alnQuality (%REAL;)>

<!--orientation of refSNP sequence to contig sequence -->
<!ELEMENT MapLoc_attlist_orient %ENUM;>
<!ATTLIST MapLoc_attlist_orient value (
        forward |
        reverse
        ) #REQUIRED >


<!--chromosome position as integer for sorting -->
<!ELEMENT MapLoc_attlist_physMapInt (%INTEGER;)>

<!--nearest aligned position in 5' flanking sequence of snp -->
<!ELEMENT MapLoc_attlist_leftFlankNeighborPos (%INTEGER;)>

<!--nearest aligned position in 3' flanking sequence of snp  -->
<!ELEMENT MapLoc_attlist_rightFlankNeighborPos (%INTEGER;)>

<!--nearest aligned position in 5' contig alignment of snp -->
<!ELEMENT MapLoc_attlist_leftContigNeighborPos (%INTEGER;)>

<!--nearest aligned position in 3' contig alignment of snp -->
<!ELEMENT MapLoc_attlist_rightContigNeighborPos (%INTEGER;)>

<!--number of Mismatched positions in this alignment -->
<!ELEMENT MapLoc_attlist_numberOfMismatches (%INTEGER;)>

<!--number of deletions in this alignment -->
<!ELEMENT MapLoc_attlist_numberOfDeletions (%INTEGER;)>

<!--number of insetions in this alignment -->
<!ELEMENT MapLoc_attlist_numberOfInsertions (%INTEGER;)>

<!ELEMENT MapLoc_fxnSet (FxnSet*)>


<!ELEMENT PrimarySequence (
        PrimarySequence_attlist, 
        PrimarySequence_mapLoc)>

<!ELEMENT PrimarySequence_attlist (
        PrimarySequence_attlist_dbSnpBuild, 
        PrimarySequence_attlist_gi, 
        PrimarySequence_attlist_source?, 
        PrimarySequence_attlist_accession?)>

<!ELEMENT PrimarySequence_attlist_dbSnpBuild (%INTEGER;)>

<!ELEMENT PrimarySequence_attlist_gi (%INTEGER;)>

<!ELEMENT PrimarySequence_attlist_source %ENUM;>
<!ATTLIST PrimarySequence_attlist_source value (
        submitter |
        blastmb |
        xm |
        remap
        ) #REQUIRED >


<!ELEMENT PrimarySequence_attlist_accession (#PCDATA)>

<!ELEMENT PrimarySequence_mapLoc (MapLoc*)>

<!--defines the docsum structure for refSNP clusters, where a refSNP cluster (rs) is a grouping of individual dbSNP submissions that all refer to the same variation. The refsnp provides a single unified record for annotation of NCBI resources such as reference genome sequence. -->
<!ELEMENT Rs (
        Rs_attlist, 
        Rs_het?, 
        Rs_validation, 
        Rs_create, 
        Rs_update?, 
        Rs_sequence, 
        Rs_ss, 
        Rs_assembly?, 
        Rs_primarySequence?, 
        Rs_rsStruct?, 
        Rs_rsLinkout?, 
        Rs_mergeHistory?, 
        Rs_hgvs?)>

<!ELEMENT Rs_attlist (
        Rs_attlist_rsId, 
        Rs_attlist_snpClass, 
        Rs_attlist_snpType, 
        Rs_attlist_molType, 
        Rs_attlist_validProbMin?, 
        Rs_attlist_validProbMax?, 
        Rs_attlist_genotype?, 
        Rs_attlist_bitField?)>

<!--refSNP (rs) number -->
<!ELEMENT Rs_attlist_rsId (%INTEGER;)>

<!ELEMENT Rs_attlist_snpClass %ENUM;>
<!ATTLIST Rs_attlist_snpClass value (
        snp |
        in-del |
        heterozygous |
        microsatellite |
        named-locus |
        no-variation |
        mixed |
        multinucleotide-polymorphism
        ) #REQUIRED >


<!ELEMENT Rs_attlist_snpType %ENUM;>
<!ATTLIST Rs_attlist_snpType value (
        notwithdrawn |
        artifact |
        gene-duplication |
        duplicate-submission |
        notspecified |
        ambiguous-location |
        low-map-quality
        ) #REQUIRED >


<!ELEMENT Rs_attlist_molType %ENUM;>
<!ATTLIST Rs_attlist_molType value (
        genomic |
        cDNA |
        mito |
        chloro |
        unknown
        ) #REQUIRED >


<!--minimum reported success rate of all submissions in cluster -->
<!ELEMENT Rs_attlist_validProbMin (%INTEGER;)>

<!--maximum reported success rate of all submissions in cluster -->
<!ELEMENT Rs_attlist_validProbMax (%INTEGER;)>

<!--at least one genotype reported for this refSNP -->
<!ELEMENT Rs_attlist_genotype EMPTY>
<!ATTLIST Rs_attlist_genotype value ( true | false ) #REQUIRED >


<!ELEMENT Rs_attlist_bitField (#PCDATA)>

<!ELEMENT Rs_het (
        Rs_het_attlist, 
        Rs_het_het)>

<!ELEMENT Rs_het_attlist (
        Rs_het_attlist_type, 
        Rs_het_attlist_value, 
        Rs_het_attlist_stdError?)>

<!--Est=Estimated average het from allele frequencies, Obs=Observed from genotype data -->
<!ELEMENT Rs_het_attlist_type %ENUM;>
<!ATTLIST Rs_het_attlist_type value (
        est |
        obs
        ) #REQUIRED >


<!--Heterozygosity -->
<!ELEMENT Rs_het_attlist_value (%REAL;)>

<!--Standard error of Het estimate -->
<!ELEMENT Rs_het_attlist_stdError (%REAL;)>

<!ELEMENT Rs_het_het EMPTY>

<!ELEMENT Rs_validation (
        Rs_validation_attlist, 
        Rs_validation_otherPopBatchId?, 
        Rs_validation_twoHit2AlleleBatchId?)>

<!ELEMENT Rs_validation_attlist (
        Rs_validation_attlist_byCluster?, 
        Rs_validation_attlist_byFrequency?, 
        Rs_validation_attlist_byOtherPop?, 
        Rs_validation_attlist_by2Hit2Allele?, 
        Rs_validation_attlist_byHapMap?)>

<!--at least one subsnp in cluster has frequency data submitted -->
<!ELEMENT Rs_validation_attlist_byCluster EMPTY>
<!ATTLIST Rs_validation_attlist_byCluster value ( true | false ) #REQUIRED >


<!--cluster has 2+ submissions, with 1+ submissions assayed with a non-computational method -->
<!ELEMENT Rs_validation_attlist_byFrequency EMPTY>
<!ATTLIST Rs_validation_attlist_byFrequency value ( true | false ) #REQUIRED >


<!ELEMENT Rs_validation_attlist_byOtherPop EMPTY>
<!ATTLIST Rs_validation_attlist_byOtherPop value ( true | false ) #REQUIRED >


<!--cluster has 2+ submissions, with 1+ submissions assayed with a non-computational method -->
<!ELEMENT Rs_validation_attlist_by2Hit2Allele EMPTY>
<!ATTLIST Rs_validation_attlist_by2Hit2Allele value ( true | false ) #REQUIRED >


<!--TBD -->
<!ELEMENT Rs_validation_attlist_byHapMap EMPTY>
<!ATTLIST Rs_validation_attlist_byHapMap value ( true | false ) #REQUIRED >


<!--dbSNP batch-id's for other pop snp validation data. -->
<!ELEMENT Rs_validation_otherPopBatchId (Rs_validation_otherPopBatchId_E*)>


<!ELEMENT Rs_validation_otherPopBatchId_E (%INTEGER;)>

<!--dbSNP batch-id's for double-hit snp validation data. Use batch-id to get methods, etc. -->
<!ELEMENT Rs_validation_twoHit2AlleleBatchId (Rs_validation_twoHit2AlleleBatchId_E*)>


<!ELEMENT Rs_validation_twoHit2AlleleBatchId_E (%INTEGER;)>
<!--date the refsnp cluster was instantiated -->
<!--date the refsnp cluster was instantiated -->
<!ELEMENT Rs_create (
        Rs_create_attlist, 
        Rs_create_create)>
<!--date the refsnp cluster was instantiated -->
<!ELEMENT Rs_create_attlist (
        Rs_create_attlist_build?, 
        Rs_create_attlist_date?)>

<!--build number when the cluster was created -->
<!ELEMENT Rs_create_attlist_build (%INTEGER;)>

<!--yyyy-mm-dd -->
<!ELEMENT Rs_create_attlist_date (#PCDATA)>

<!--date the refsnp cluster was instantiated -->
<!ELEMENT Rs_create_create EMPTY>
<!--most recent date the cluster was updated (member added or deleted) -->
<!--most recent date the cluster was updated (member added or deleted) -->
<!ELEMENT Rs_update (
        Rs_update_attlist, 
        Rs_update_update)>
<!--most recent date the cluster was updated (member added or deleted) -->
<!ELEMENT Rs_update_attlist (
        Rs_update_attlist_build?, 
        Rs_update_attlist_date?)>

<!--build number when the cluster was updated -->
<!ELEMENT Rs_update_attlist_build (%INTEGER;)>

<!--yyyy-mm-dd -->
<!ELEMENT Rs_update_attlist_date (#PCDATA)>

<!--most recent date the cluster was updated (member added or deleted) -->
<!ELEMENT Rs_update_update EMPTY>

<!ELEMENT Rs_sequence (
        Rs_sequence_attlist, 
        Rs_sequence_seq5?, 
        Rs_sequence_observed, 
        Rs_sequence_seq3?)>

<!ELEMENT Rs_sequence_attlist (
        Rs_sequence_attlist_exemplarSs)>

<!--dbSNP ss# selected as source of refSNP flanking sequence, ss# part of ss-list below  -->
<!ELEMENT Rs_sequence_attlist_exemplarSs (%INTEGER;)>

<!--
5' sequence that flanks the variation
5' sequence that flanks the variation
-->
<!ELEMENT Rs_sequence_seq5 (#PCDATA)>

<!--
list of all nucleotide alleles observed in ss-list members, correcting for reverse complementation of memebers reported in reverse orientation
list of all nucleotide alleles observed in ss-list members, correcting for reverse complementation of memebers reported in reverse orientation
-->
<!ELEMENT Rs_sequence_observed (#PCDATA)>

<!--
3' sequence that flanks the variation
3' sequence that flanks the variation
-->
<!ELEMENT Rs_sequence_seq3 (#PCDATA)>

<!ELEMENT Rs_ss (Ss*)>

<!ELEMENT Rs_assembly (Assembly*)>

<!ELEMENT Rs_primarySequence (PrimarySequence*)>

<!ELEMENT Rs_rsStruct (RsStruct*)>

<!ELEMENT Rs_rsLinkout (RsLinkout*)>

<!ELEMENT Rs_mergeHistory (Rs_mergeHistory_E*)>


<!ELEMENT Rs_mergeHistory_E (
        Rs_mergeHistory_E_attlist, 
        Rs_mergeHistory_E_mergeHistory)>

<!ELEMENT Rs_mergeHistory_E_attlist (
        Rs_mergeHistory_E_attlist_rsId, 
        Rs_mergeHistory_E_attlist_buildId?, 
        Rs_mergeHistory_E_attlist_orientFlip?)>

<!--previously issued rs id whose member assays have now been merged -->
<!ELEMENT Rs_mergeHistory_E_attlist_rsId (%INTEGER;)>

<!--build id when rs id was merged into parent rs -->
<!ELEMENT Rs_mergeHistory_E_attlist_buildId (%INTEGER;)>

<!--TRUE if strand of rs id is reverse to parent object's current strand -->
<!ELEMENT Rs_mergeHistory_E_attlist_orientFlip EMPTY>
<!ATTLIST Rs_mergeHistory_E_attlist_orientFlip value ( true | false ) #REQUIRED >


<!ELEMENT Rs_mergeHistory_E_mergeHistory EMPTY>

<!--							HGVS name list -->
<!ELEMENT Rs_hgvs (Rs_hgvs_E*)>


<!ELEMENT Rs_hgvs_E (#PCDATA)>

<!--link data for another resource -->
<!ELEMENT RsLinkout (
        RsLinkout_attlist, 
        RsLinkout_rsLinkout)>

<!ELEMENT RsLinkout_attlist (
        RsLinkout_attlist_resourceId, 
        RsLinkout_attlist_linkValue)>

<!--BaseURLList.url_id -->
<!ELEMENT RsLinkout_attlist_resourceId (#PCDATA)>

<!--value to append to ResourceURL.base-url for complete link -->
<!ELEMENT RsLinkout_attlist_linkValue (#PCDATA)>

<!--link data for another resource -->
<!ELEMENT RsLinkout_rsLinkout EMPTY>

<!--structure information for SNP -->
<!ELEMENT RsStruct (
        RsStruct_attlist, 
        RsStruct_rsStruct)>

<!ELEMENT RsStruct_attlist (
        RsStruct_attlist_protAcc?, 
        RsStruct_attlist_protGi?, 
        RsStruct_attlist_protLoc?, 
        RsStruct_attlist_protResidue?, 
        RsStruct_attlist_rsResidue?, 
        RsStruct_attlist_structGi?, 
        RsStruct_attlist_structLoc?, 
        RsStruct_attlist_structResidue?)>

<!--accession of the protein with variation -->
<!ELEMENT RsStruct_attlist_protAcc (#PCDATA)>

<!--GI of the protein with variation -->
<!ELEMENT RsStruct_attlist_protGi (%INTEGER;)>

<!--position of the residue for the protein GI -->
<!ELEMENT RsStruct_attlist_protLoc (%INTEGER;)>

<!--residue specified for protein at prot-loc location -->
<!ELEMENT RsStruct_attlist_protResidue (#PCDATA)>

<!--alternative residue specified by variation sequence -->
<!ELEMENT RsStruct_attlist_rsResidue (#PCDATA)>

<!--GI of the structure neighbor -->
<!ELEMENT RsStruct_attlist_structGi (%INTEGER;)>

<!--position of the residue for the structure GI -->
<!ELEMENT RsStruct_attlist_structLoc (%INTEGER;)>

<!--residue specified for protein at struct-loc location -->
<!ELEMENT RsStruct_attlist_structResidue (#PCDATA)>

<!--structure information for SNP -->
<!ELEMENT RsStruct_rsStruct EMPTY>

<!--data for an individual submission to dbSNP -->
<!ELEMENT Ss (
        Ss_attlist, 
        Ss_sequence)>

<!ELEMENT Ss_attlist (
        Ss_attlist_ssId, 
        Ss_attlist_handle, 
        Ss_attlist_batchId, 
        Ss_attlist_locSnpId?, 
        Ss_attlist_subSnpClass?, 
        Ss_attlist_orient?, 
        Ss_attlist_strand?, 
        Ss_attlist_molType?, 
        Ss_attlist_buildId?, 
        Ss_attlist_methodClass?, 
        Ss_attlist_validated?, 
        Ss_attlist_linkoutUrl?)>

<!--dbSNP accession number for submission -->
<!ELEMENT Ss_attlist_ssId (%INTEGER;)>

<!--Tag for the submitting laboratory -->
<!ELEMENT Ss_attlist_handle (#PCDATA)>

<!--dbSNP number for batch submission -->
<!ELEMENT Ss_attlist_batchId (%INTEGER;)>

<!--
submission (ss#)
submitter ID
-->
<!ELEMENT Ss_attlist_locSnpId (#PCDATA)>

<!--SubSNP classification by type of variation -->
<!ELEMENT Ss_attlist_subSnpClass %ENUM;>
<!ATTLIST Ss_attlist_subSnpClass value (
        snp |
        in-del |
        heterozygous |
        microsatellite |
        named-locus |
        no-variation |
        mixed |
        multinucleotide-polymorphism
        ) #REQUIRED >

<!--
orientation of refsnp cluster members to refsnp cluster sequence
ss flanking sequence is in same orientation as seq-ss-exemplar
lanking sequence and alleles are reverse complement of refSNP as defined by ss exemplar
-->
<!ELEMENT Ss_attlist_orient %ENUM;>
<!ATTLIST Ss_attlist_orient value (
        forward |
        reverse
        ) #REQUIRED >


<!--strand is defined as TOP/BOTTOM by nature of flanking nucleotide sequence -->
<!ELEMENT Ss_attlist_strand %ENUM;>
<!ATTLIST Ss_attlist_strand value (
        top |
        bottom
        ) #REQUIRED >


<!--moltype from Batch table -->
<!ELEMENT Ss_attlist_molType %ENUM;>
<!ATTLIST Ss_attlist_molType value (
        genomic |
        cDNA |
        mito |
        chloro |
        unknown
        ) #REQUIRED >


<!--dbSNP build number when ss# was added to a refSNP (rs#) cluster -->
<!ELEMENT Ss_attlist_buildId (%INTEGER;)>
<!--
class of method used to assay for the variation
Denaturing High Pressure Liquid Chromatography used to detect SNP
a hybridization method (e.g. chip) was used to assay for variation
variation was mined from sequence alignment with software
samples were sequenced and resulting alignment used to define variation
-->
<!ELEMENT Ss_attlist_methodClass %ENUM;>
<!ATTLIST Ss_attlist_methodClass value (
        dHPLC |
        hybridize |
        computed |
        sSCP |
        other |
        unknown |
        rFLP |
        sequence
        ) #REQUIRED >

<!--
subsnp has been experimentally validated by submitter
subsnp has frequency data submitted
has 2+ submissions, with 1+ submission assayed with a non-computational method
-->
<!ELEMENT Ss_attlist_validated %ENUM;>
<!ATTLIST Ss_attlist_validated value (
        by-submitter |
        by-frequency |
        by-cluster
        ) #REQUIRED >


<!--append loc-snp-id to this base URL to construct a pointer to submitter data. -->
<!ELEMENT Ss_attlist_linkoutUrl (#PCDATA)>

<!ELEMENT Ss_sequence (
        Ss_sequence_seq5?, 
        Ss_sequence_observed, 
        Ss_sequence_seq3?)>

<!--
5' sequence that flanks the variation
5' sequence that flanks the variation
-->
<!ELEMENT Ss_sequence_seq5 (#PCDATA)>

<!--
list of all nucleotide alleles observed in ss-list members, correcting for reverse complementation of memebers reported in reverse orientation
list of all nucleotide alleles observed in ss-list members, correcting for reverse complementation of memebers reported in reverse orientation
-->
<!ELEMENT Ss_sequence_observed (#PCDATA)>

<!--
3' sequence that flanks the variation
3' sequence that flanks the variation
-->
<!ELEMENT Ss_sequence_seq3 (#PCDATA)>