ó
¶GæIc           @   sC  d  d l  m Z d  d l m Z d  d l Td  d l m Z d  d l Z d  d l m Z d  d l	 Z	 d  d l
 m Z d e f d	 „  ƒ  YZ d
 e j f d „  ƒ  YZ d d d „  ƒ  YZ d e f d „  ƒ  YZ d d d „  ƒ  YZ d d d „  ƒ  YZ d d d „  ƒ  YZ d e f d „  ƒ  YZ d d  d „  ƒ  YZ d d! d „  ƒ  YZ d S("   iÿÿÿÿ(   t   IUPAC(   t   File(   t   *(   t   SeqN(   t   sqrt(   t   Motift	   MEMEMotifc           B   sJ   e  Z d  Z d „  Z d „  Z d „  Z d d d d d d	 „ Z d
 „  Z RS(   s  A subclass of Motif used in parsing MEME (and MAST) output.
    
    This sublcass defines functions and data specific to MEME motifs. 
    This includes the evalue for a motif and the PSSM of the motif.
    
    Methods:
    add_instance_from_values (name = 'default', pvalue = 1, sequence = 'ATA', start = 0, strand = +): create a new instance of the motif with the specified values.
    add_to_pssm (position): add a new position to the pssm. The position should be a list of nucleotide/amino acid frequencies
    add_to_logodds (position): add a new position to the log odds matrix. The position should be a tuple of log odds values for the nucleotide/amino acid at that position.
    compare_motifs (other_motif): returns the maximum correlation between this motif and other_motif
    c         C   s   t  j |  ƒ d |  _ d  S(   Ng        (   R   t   __init__t   evalue(   t   self(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR      s    c         C   s7   t  | ƒ t k r | |  _ n t | ƒ } | |  _ d  S(   N(   t   typet   intt   num_occurrences(   R	   t   number(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _numoccurrences    s    c         C   s+   x$ |  j  D] } | j | k r
 | Sq
 Wd  S(   N(   t	   instancest   sequence_namet   None(   R	   t   namet   i(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   get_instance_by_name'   s    t   defaulti   t   ATAi    t   +c         C   s   t  | |  j ƒ } | j | ƒ | j | ƒ | j | ƒ | j | ƒ |  j rb | j |  j ƒ n  |  j r~ | j	 |  j ƒ n  |  j
 | ƒ d  S(   N(   t   MEMEInstancet   alphabett   _pvaluet   _seqnamet   _startt   _strandt   lengtht   _lengthR   t
   _motifnamet   add_instance(   R	   R   t   pvaluet   sequencet   startt   strandt   inst(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   add_instance_from_values-   s    		c         C   s7   t  | ƒ t k r | |  _ n t | ƒ } | |  _ d  S(   N(   R
   t   floatR   (   R	   R   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _evalue9   s    (   t   __name__t
   __module__t   __doc__R   R   R   R'   R)   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR      s   			R   c           B   sV   e  Z d  Z d „  Z d „  Z d „  Z d „  Z d „  Z d „  Z d „  Z	 d „  Z
 RS(	   sM   A class describing the instances of a MEME motif, and the data thereof. 
    c         O   sP   t  j  j |  | | Ž d |  _ d |  _ d |  _ d |  _ d |  _ d |  _ d  S(   Nt    i    g      ð?(   R   R   R   R$   R"   R%   R   t
   motif_name(   R	   t   argst   kwds(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   D   s    					c         C   s   | |  _  d  S(   N(   R   (   R	   R   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   N   s    c         C   s   | |  _  d  S(   N(   R.   (   R	   R   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR    Q   s    c         C   s   t  | ƒ } | |  _ d  S(   N(   R   R$   (   R	   R$   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   T   s    c         C   s   t  | ƒ } | |  _ d  S(   N(   R(   R"   (   R	   t   pval(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   X   s    c         C   s   t  | ƒ } | |  _ d  S(   N(   R(   t   score(   R	   R2   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _score\   s    c         C   s   | |  _  d  S(   N(   R%   (   R	   R%   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   `   s    c         C   s   | |  _  d  S(   N(   R   (   R	   R   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   c   s    (   R*   R+   R,   R   R   R    R   R   R3   R   R   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   A   s   	
						t
   MEMERecordc           B   s    e  Z d  Z d „  Z d „  Z RS(   s²   A class for holding the results of a MEME run.
    
    A MEMERecord is an object that holds the results from running
    MEME. It implements no methods of its own.
        
    c         C   s:   g  |  _  d |  _ d |  _ d |  _ d |  _ g  |  _ d S(   s   __init__ (self)R-   N(   t   motifst   versiont   datafilet   commandR   R   t   sequence_names(   R	   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   n   s    					c         C   s+   x$ |  j  D] } | j | k r
 | Sq
 Wd  S(   N(   R5   R   (   R	   R   t   m(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   get_motif_by_namew   s    (   R*   R+   R,   R   R;   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR4   g   s   		t
   MEMEParserc           B   s    e  Z d  Z d „  Z d „  Z RS(   s  A parser for the text output of the MEME program.
    Parses the output into an object of the MEMERecord class.
    
    Methods:
    parse (handle): parses the contents of the file handle passed to it.
    
    Example:
    
    >>>f = open("meme.output.txt")
    >>>parser = MEMEParser()
    >>>meme_record = parser.parse(f)
    >>>for motif in meme_record.motifs:
    ...    for instance in motif.instances:
    ...        print instance.motif_name, instance.sequence_name, instance.strand, instance.pvalue
    
    c         C   s   t  ƒ  |  _ t ƒ  |  _ d S(   s   __init__ (self)N(   t   _MEMEScannert   _scannert   _MEMEConsumert	   _consumer(   R	   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR      s    c         C   s    |  j  j | |  j ƒ |  j j S(   s   parse (self, handle)(   R>   t   feedR@   t   data(   R	   t   handle(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   parse’   s    (   R*   R+   R,   R   RD   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR<   |   s   	R=   c           B   s)   e  Z d  Z d „  Z d „  Z d „  Z RS(   sB   Scanner for MEME output. 
    
    Methods:
    feed
        
    c         C   sN   t  | t j ƒ r | } n t j | ƒ } |  j | | ƒ |  j | | ƒ d S(   sµ   
        Feeds in MEME output for scanning. handle should
        implement the readline method. consumer is 
        a Consumer object that can receive the salient events.
        N(   t
   isinstanceR   t
   UndoHandlet   _scan_headert   _scan_motifs(   R	   RC   t   consumert   uhandle(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRA   ¡   s
    	c         C   sF  y t  | | j d d ƒWn t k
 r9 t d ƒ ‚ n Xt | | j d d ƒt  | | j d d ƒt | | j d d ƒt | | j d d ƒt | | j d d ƒt | | j d d ƒt | | j d d	 ƒt | | j d d
 ƒt  | | j d d ƒt  | | j d d ƒt | | j d d ƒt  | | j d d ƒd  S(   Nt   containss   MEME versionsF   Improper input file. File should contain a line starting MEME version.R$   s   TRAINING SETs   ****t   DATAFILEt   ALPHABETs   Sequence names   ----s   ***s   command:s   MOTIF  1(	   t   read_and_call_untilt   noeventt
   ValueErrort   read_and_callt   _versiont	   _datafilet	   _alphabett   _sequence_namet   _commandline(   R	   RJ   RI   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRG   ¯   s     c         C   sÆ  x¿t  | | j d d ƒt | | j d d ƒt  | | j d d ƒt  | | j d d ƒt  | | j d d ƒt  | | j d d ƒt | | j d d ƒt | | j d d ƒt  | | j ƒ t | | j d d ƒt | | j d d ƒt  | | j d d ƒt | | j d d ƒt | | j d d	 ƒt  | | j d d	 ƒt  | | j d
 d ƒt  | | j d d ƒt | | j d
 d ƒt  | | j d d ƒt	 | ƒ } | j
 d ƒ r Pq q Wd  S(   NR$   t   MOTIFRK   s   sorted by position p-values   ---s   Sequence names   log-odds matrixs   letter-probability matrixt   Timet   blanki   s   ***s   SUMMARY OF MOTIFS(   RQ   t   _add_motif_with_infoRN   RO   R.   R!   t   add_to_logoddst   add_to_pssmt   read_and_call_whilet   safe_peeklinet
   startswith(   R	   RJ   RI   t   line(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRH   Á   s.    (   R*   R+   R,   RA   RG   RH   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR=   ™   s   		R?   c           B   sz   e  Z d  Z d „  Z d „  Z d „  Z d „  Z d „  Z d „  Z d „  Z	 d „  Z
 d	 „  Z d
 „  Z d „  Z d „  Z RS(   s’   
    Consumer that can receive events from MEME Scanner.
    
    This is the Consumer object that should be passed to the 
    MEME Scanner.
    c         C   s"   d  |  _ g  |  _ t ƒ  |  _ d  S(   N(   R   t   current_motifR9   R4   RB   (   R	   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   ä   s    		c         C   s,   | j  ƒ  } | j ƒ  } | d |  j _ d  S(   Ni   (   t   stript   splitRB   R6   (   R	   R`   t   ls(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRR   é   s    c         C   s.   | j  ƒ  } | j d d ƒ } | |  j _ d  S(   Ns
   DATAFILE= R-   (   Rb   t   replaceRB   R7   (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRS   î   s    c         C   sO   | j  ƒ  } | j d d ƒ } | d k r6 t j } n	 t j } | |  j _ d  S(   Ns
   ALPHABET= R-   t   ACGT(   Rb   Re   R    t   unambiguous_dnat   proteinRB   R   (   R	   R`   t   al(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRT   ó   s    	c         C   s_   | j  ƒ  } | j ƒ  } |  j j j | d ƒ t | ƒ d k r[ |  j j j | d ƒ n  d  S(   Ni    i   i   (   Rb   Rc   RB   R9   t   appendt   len(   R	   R`   Rd   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRU   ü   s
    c         C   s.   | j  ƒ  } | j d d ƒ } | |  j _ d  S(   Ns	   command: R-   (   Rb   Re   RB   R8   (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRV     s    c         C   sr   | j  ƒ  } | j ƒ  } t ƒ  } | j | d ƒ | j | d ƒ |  j j | _ |  j j j | ƒ | |  _	 d  S(   Ni   i   (
   Rb   Rc   R   R   R)   RB   R   R5   Rj   Ra   (   R	   R`   Rd   t   motif(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRZ     s    	c         C   s>   | j  ƒ  } | j ƒ  } d j | d d !ƒ } | |  j _ d  S(   Nt    i    i   (   Rb   Rc   t   joinRa   R   (   R	   R`   Rd   R   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR.     s    c         C   s®   | j  ƒ  } | j ƒ  } |  j j j d ƒ d k ru |  j j d | d d | d d | d d	 | d
 d | d ƒ n5 |  j j d | d d | d d | d d	 | d ƒ d  S(   Nt   revcompiÿÿÿÿR   i    R#   i   R$   i   R"   i   R%   i   i   (   Rb   Rc   RB   R8   t   findRa   R'   (   R	   R`   Rd   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR!     s
    Bc         C   s   d  S(   N(    (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR\   #  s    c         C   s   d  S(   N(    (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR[   &  s    c         C   s   d  S(   N(    (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRO   )  s    (   R*   R+   R,   R   RR   RS   RT   RU   RV   RZ   R.   R!   R\   R[   RO   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR?   Ü   s   										
		t   _MASTConsumerc           B   sŒ   e  Z d  Z d „  Z d „  Z d „  Z d „  Z d „  Z d „  Z d „  Z	 d „  Z
 d	 „  Z d
 „  Z d „  Z d „  Z d „  Z d „  Z RS(   sÌ  
    Consumer that can receive events from _MASTScanner.
    
    A _MASTConsumer parses lines from a mast text output file.
    The motif match diagrams are parsed using line buffering. 
    Each of the buffering functions have a dummy variable that is
    required for testing using the Bio.ParserSupport.TaggingConsumer.
    If this variable isn't there, the TaggingConsumer barfs. In
    the _MASTScanner, None is passed in the place of this variable.
    c         C   s4   t  ƒ  |  _ d |  _ g  |  _ d |  _ d |  _ d  S(   NR-   i    (   t
   MASTRecordRB   t   _current_seqt   _line_buffert   _buffer_sizet   _buffered_seq_start(   R	   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   9  s
    			c         C   s0   | j  ƒ  } | j ƒ  } |  j j | d ƒ d  S(   Ni   (   Rb   Rc   RB   RR   (   R	   R`   Rd   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRR   @  s    c         C   s{   | j  ƒ  } | j ƒ  } |  j j | d ƒ d } | d d k r^ t j } |  j j | ƒ n t j } |  j j | ƒ d  S(   Ni   R-   i   s   (nucleotide)(   Rb   Rc   RB   t	   _databaseR    Rg   RT   Rh   (   R	   R`   Rd   Ri   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRw   E  s    		c         C   su   | j  ƒ  } | j ƒ  } t ƒ  } |  j j | _ | d | _ | d } | | _ | j | d ƒ |  j j | ƒ d  S(   Ni   i    i   (	   Rb   Rc   R   RB   R   R   R   R!   t
   _add_motif(   R	   R`   Rd   R:   R   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRx   Q  s    	
	c   
      C   sd  | j  ƒ  } | j ƒ  } |  j j | d |  j ƒ | d j d ƒ } d } d } xt d t | ƒ ƒ D]õ } | | j d ƒ d k sŸ | | j d ƒ d k rHt ƒ  } | j	 |  j ƒ | j
 | ƒ t j d ƒ } | j | | ƒ d } | | j d ƒ d k rd | _ n	 d	 | _ |  j j | ƒ }	 |	 j | ƒ | |	 j 7} qg | t | | ƒ 7} qg Wd  S(
   Ni   t   _i    t   [iÿÿÿÿt   <s   \d+t   -R   (   Rb   Rc   RB   t   _add_diagram_for_sequenceRs   t   rangeRk   Rp   R   R   R   t   ret   compilet   findallR%   R;   R!   R   R   (
   R	   R`   Rd   t   dsR   R$   R&   t   rt   mnRl   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _add_match_diagram\  s(    2		c   
      C   sz  | j  ƒ  } | j ƒ  } |  j j | d ƒ |  j j | d | d ƒ | d j d ƒ } d } d } xt d t | ƒ ƒ D]ö } | | j d ƒ d k s´ | | j d ƒ d k r^t ƒ  } | j	 | d ƒ | j
 | ƒ t j d ƒ } | j | | ƒ d } | | j d ƒ d k r&d | _ n	 d | _ |  j j | ƒ }	 |	 j | ƒ | |	 j 7} q| | t | | ƒ 7} q| Wd  S(   Ni    i   Ry   R   iÿÿÿÿR|   s   \d+(   Rb   Rc   RB   t   _add_sequenceR}   R~   Rk   Rp   R   R   R   R   R€   R   R%   R;   R!   R   R   (
   R	   R`   Rd   R‚   R   R$   R&   Rƒ   R„   Rl   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt    _add_sequence_match_with_diagramt  s*    2		c         C   s‚  d } x! |  j  D] } | | j ƒ  7} q W| j ƒ  } |  j j | d |  j ƒ | d j d ƒ } d } d } xt d t | ƒ ƒ D]õ } | | j d ƒ d k s½ | | j d ƒ d k rft	 ƒ  } | j
 |  j ƒ | j | ƒ t j d ƒ }	 |	 j | | ƒ d }
 | | j d	 ƒ d k r.d	 | _ n	 d
 | _ |  j j |
 ƒ } | j | ƒ | | j 7} q… | t | | ƒ 7} q… Wd  S(   NR-   i   Ry   i    Rz   iÿÿÿÿR{   s   \d+R|   R   (   Rt   Rb   Rc   RB   R}   Rs   R~   Rk   Rp   R   R   R   R   R€   R   R%   R;   R!   R   R   (   R	   t   dummyR`   t   lRd   R‚   R   R$   R&   Rƒ   R„   Rl   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _add_diagram_from_buffer  s,    2		c         C   sD   | j  ƒ  } | |  _ |  j j j | ƒ s@ |  j j j | ƒ n  d  S(   N(   Rb   Rs   RB   t	   sequencest   countRj   (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _set_current_seq§  s    	c         C   s6   | j  ƒ  } | j d ƒ s. |  j j | ƒ n d Sd  S(   Ns   *****iÿÿÿÿ(   Rb   R_   Rt   Rj   (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _add_line_to_buffer­  s    c         C   s–  |  j  j |  j ƒ } t | ƒ d k r’|  j |  j d } |  j d j ƒ  } d } t | ƒ } x6| | k  r˜| | j d ƒ d k r‹g  } | | j d ƒ } | j ƒ  | d j	 d ƒ }	 |	 d k rç | d d d | d }
 n | d |	 d d | d }
 | j
 |
 ƒ xt d t | ƒ ƒ D]} | | j	 d ƒ }	 | | d j	 d ƒ } |	 d k rÉ| d k r™| | |	 d d | | d d  }
 q#| | |	 d d | | d d | d !}
 nZ | d k rú| | d d | | d d  }
 n) | | d d | | d d | d !}
 | j
 |
 ƒ q(W| j ƒ  | d k rj| d | !| | | d } n | | | d } t | ƒ } n  | d 7} qc Wd } t | ƒ t | ƒ k røt j j d |  j d |  j d d	 t | ƒ d
 ƒ g  } n  x— t d t | ƒ ƒ D]} } | | } | j |  j d } | | | | j !} t j | |  j  j ƒ } | j | ƒ | r| j t | | ƒ ƒ qqWn  d S(   s©   Parses the line buffer to get e-values for each instance of a motif.
        This buffer parser is the most likely point of failure for the 
        MASTParser.
        i    i   t   et   .iÿÿÿÿi   s   Failure to parse p-values for s   :  s    to: s   
N(   RB   t   get_motif_matches_for_sequenceRs   Rk   Rt   Ru   Rc   RŒ   t   reverseRp   Rj   R~   t   syst   stderrt   writet   strR$   Rv   R   R   R   t	   _sequenceR   R(   (   R	   Rˆ   t   instst   fullSeqt   pvalst   pt   lpvalt   pvst   spet   dotindt   thispvalt   spit
   prevdotindR   R&   R$   t   thisSeq(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _parse_buffer´  sZ    
)0%)
 8	
c         C   s   g  |  _  d |  _ d  S(   Ni    (   Rt   Ru   (   R	   Rˆ   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _blank_bufferñ  s    	c         C   sÛ  |  j  d k r t |  j ƒ d k r×t |  j ƒ |  _  |  j |  j  d j ƒ  } | d |  j |  j  d <t | d ƒ |  _ q×nVd } xZ t |  j  t |  j ƒ d ƒ D]9 } |  j | |  j  |  j | j ƒ  |  j | |  j  <q§ W|  j t |  j ƒ d j ƒ  } t | d ƒ |  j t |  j |  j  d ƒ k rV|  j |  j  d c | d 7<nk t | d ƒ |  j t |  j |  j  d ƒ } |  j |  j  d c d | 7<|  j |  j  d c | d 7<|  j d |  j  !|  _ d  S(   Ni    i   t   N(   Ru   Rk   Rt   Rc   R   Rv   R~   Rb   (   R	   Rˆ   t   llR   t   differ(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _collapse_bufferõ  s     &7 1!/c         C   sm   | j  ƒ  } | j d ƒ d k si | j d ƒ d k r9 n0 | j d ƒ d k rQ n | j d ƒ d k ri n  d  S(   NRz   iÿÿÿÿR{   R   R   (   Rb   Rp   (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   _add_motif_match	  s    *c         C   s   d  S(   N(    (   R	   R`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRO     s    (   R*   R+   R,   R   RR   Rw   Rx   R…   R‡   RŠ   R   RŽ   R¤   R¥   R©   Rª   RO   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRq   .  s   
										=				t
   MASTParserc           B   s    e  Z d  Z d „  Z d „  Z RS(   s>  
    Parser for MAST text output. HTML output cannot be parsed, yet. Returns a MASTRecord
    
    A MASTParser takes a file handle for a MAST text output file and 
    returns a MASTRecord, containing the hits between motifs and 
    sequences. The parser does some unusual line buffering to parse out 
    match diagrams. Really complex diagrams often lead to an error message 
    and p-values not being parsed for a given line.
    
    Methods:
    parse (handle): parses the data from the file handle passed to it.
    
    Example:
    
    >>>f = open("mast_file.txt")
    >>>parser = MASTParser()
    >>>mast_record = parser.parse(f)
    >>>for motif in mast_record.motifs:
    >>>    for instance in motif.instances:
    >>>        print instance.motif_name, instance.sequence_name, instance.strand, instance.pvalue
    c         C   s   t  ƒ  |  _ t ƒ  |  _ d  S(   N(   Rq   R@   t   _MASTScannerR>   (   R	   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   -  s    c         C   s    |  j  j | |  j ƒ |  j j S(   N(   R>   RA   R@   RB   (   R	   RC   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRD   1  s    (   R*   R+   R,   R   RD   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR«     s   	R¬   c           B   s2   e  Z d  Z d „  Z d „  Z d „  Z d „  Z RS(   s1   
    Scanner for MAST text output. 
        
    c         C   s^   t  | t j ƒ r | } n t j | ƒ } |  j | | ƒ |  j | | ƒ |  j | | ƒ d  S(   N(   RE   R   RF   RG   t   _scan_matchest   _scan_annotated_matches(   R	   RC   RI   RJ   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRA   <  s    	c         C   s  y t  | | j d d ƒWn t k
 r9 t d ƒ ‚ n Xt | | j d d ƒt  | | j d d ƒt | | j d d ƒt | | j d d ƒt | | j d d ƒt  | | j d d ƒt | | j d d	 ƒt | | j d d
 ƒt  | | j d d ƒt  | | j d d ƒd  S(   NRK   s   MAST versionsC   Improper input file. Does not begin with a line with 'MAST version'R$   s   DATABASE AND MOTIFSt   DATABASEs   ****s   MOTIF WIDTHRW   s   ----RY   i   s   SECTION II:(   RN   RO   RP   RQ   RR   Rw   Rx   (   R	   RJ   RI   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRG   F  s    c         C   sr   t  | | j d d ƒt | | j d d ƒt | | j d d ƒt  | | j d d ƒt | | j d d ƒd  S(   NR$   s   SEQUENCE NAMEs   ---RY   i   (   RN   RO   RQ   (   R	   RJ   RI   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR­   V  s
    c         C   s  t  | | j d d ƒt | | j d d ƒt  | | j d d ƒt | | j d d ƒt  | | j d d ƒt | | j ƒ t | | j d d ƒd } x~| d k r| j rá | j d k rÑ | j d  ƒ n  | j d  ƒ n  t | | j	 ƒ t  | | j d d ƒt  | | j
 d d ƒ| j d  ƒ | j d  ƒ t | | j d d ƒxÇ t | ƒ } | j d ƒ r‚| j d  ƒ d } Pn  t  | | j
 d d ƒt | | j d d ƒ| j d  ƒ t | | j d d ƒr×PqPt | | j d d ƒrP| j d  ƒ | j d  ƒ d } PqPqPWq Wd  S(	   NR$   s   SECTION III:s   ****s   *****RY   i   i    s	     DIAGRAM(   RN   RO   RQ   R]   Rs   Ru   R¤   R   R¥   R   RŽ   RŠ   R^   R_   R©   t   attempt_read_and_call(   R	   RJ   RI   t   readMatchesR`   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR®   ^  sF    	(   R*   R+   R,   RA   RG   R­   R®   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR¬   7  s
   	
		Rr   c           B   sq   e  Z d  Z d „  Z d „  Z d „  Z d „  Z d „  Z d „  Z d „  Z	 d „  Z
 d	 „  Z d
 „  Z d „  Z RS(   sv  The class for holding the results from a MAST run.
    
    A MASTRecord holds data about matches between motifs and sequences.
    The motifs held by the MASTRecord are objects of the class MEMEMotif.
    
    Methods:
    get_motif_matches_for_sequence(sequence_name): returns all of the
    motif matches within a given sequence. The matches are objects of
    the class MEMEInstance
    get_motif_matches (motif_name): returns all of the matches for a motif
    in the sequences searched. The matches returned are of class 
    MEMEInstance
    get_motif_by_name (motif_name): returns a MEMEMotif with the given
    name.
    c         C   sC   g  |  _  d |  _ g  |  _ d |  _ i  |  _ d  |  _ g  |  _ d  S(   NR-   (   R‹   R6   t   matchest   databaset   diagramsR   R   R5   (   R	   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR   •  s    						c         C   s   | |  _  d  S(   N(   R6   (   R	   R6   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRR   ž  s    c         C   sA   | t  j k s- | t  j k s- | t  j k r9 | |  _ n d Sd  S(   Niÿÿÿÿ(   R    Rh   t   ambiguous_dnaRg   R   (   R	   R   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRT   ¡  s    -c         C   s   | |  _  d  S(   N(   R³   (   R	   R³   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRw   §  s    c         C   sa   g  } xD |  j  D]9 } x0 | j D]% } | j | k r  | j | ƒ q  q  Wq W| j d „  ƒ | S(   Nc         S   s   t  |  j | j ƒ S(   N(   t   cmpR$   (   t   xt   y(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   <lambda>°  s    (   R5   R   R   Rj   t   sort(   R	   t   seqR˜   R:   R   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR‘   ª  s    c         C   s   |  j  | j ƒ } | j S(   N(   R;   R   R   (   R	   Rl   R:   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   get_motif_matches³  s    c         C   s   | |  j  | <d  S(   N(   R´   (   R	   t   diagramR»   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR}   ·  s    c         C   s   |  j  j | ƒ d  S(   N(   R²   Rj   (   R	   t   match(    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt
   _add_matchº  s    c         C   s   |  j  j | ƒ d  S(   N(   R‹   Rj   (   R	   R#   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR†   ½  s    c         C   s   |  j  j | ƒ d  S(   N(   R5   Rj   (   R	   Rl   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRx   À  s    c         C   s+   x$ |  j  D] } | j | k r
 | Sq
 Wd  S(   N(   R5   R   (   R	   R   R:   (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyR;   Ã  s    (   R*   R+   R,   R   RR   RT   Rw   R‘   R¼   R}   R¿   R†   Rx   R;   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyRr   …  s   												(    (    (    (    (    (    (   t   Bio.AlphabetR    t   BioR   t   Bio.ParserSupportR   R   t   mathR   R“   t	   Bio.MotifR   R   R   R4   t   AbstractParserR<   R=   R?   Rq   R«   R¬   Rr   (    (    (    s‰   /oak/stanford/groups/akundaje/marinovg/programs/biopython-1.50.tar.gz/biopython-1.50/build/lib.linux-x86_64-2.7/Bio/Motif/Parsers/MEME.pyt   <module>   s"   
1&CRé N