# FREQS A 0.325 C 0.175 G 0.175 T 0.325
    A   R   G   C   Y   T   K   M   S   W   N   X
A   8   2  -2 -12 -13 -15  -9  -2  -7  -3  -1 -27
R   0   2   4 -11 -13 -14  -5  -5  -3  -6  -1 -27
G  -6   2  10 -11 -12 -13  -1  -8   0  -9  -1 -27
C -13 -12 -11  10   2  -6  -8  -1   0  -9  -1 -27
Y -14 -13 -11   4   2   0  -5  -5  -3  -6  -1 -27
T -15 -13 -12  -2   2   8  -2  -9  -7  -3  -1 -27
K -10  -5   0  -7  -5  -2  -1  -9  -3  -6  -1 -27
M  -2  -5  -7   0  -5 -10  -9  -1  -3  -6  -1 -27
S  -9  -5   0   0  -5  -9  -5  -5   0  -9  -1 -27
W  -3  -5  -7  -7  -5  -3  -5  -5  -7  -3  -1 -27
N  -1  -1  -1  -1  -1  -1  -1  -1  -1  -1  -1 -27
X -27 -27 -27 -27 -27 -27 -27 -27 -27 -27 -27 -27