#	Sequenced Read Pairs	Normal Paired	Chimeric Paired	Chimeric Ambiguous	Unmapped	Ligation Motif Present	Alignable (Normal+Chimeric Paired)	Unique Reads	PCR Duplicates	Optical Duplicates	Library Complexity Estimate	Intra-fragment Reads	Hi-C Contacts	Hi-C Contacts Ligation Motif Present	Hi-C Contacts 3p Bias (Long Range)	Hi-C Contacts Pair Type (L-I-O-R)	Inter-chromosomal	Intra-chromosomal	Short Range (<20Kb)	Long Range (>20Kb)
L1240-SSB01-a_amanitin-0h-Hi-C	111,333,226	72,338,526 (64.97%)	0 (0.00%)	0 (0.00%)	38,994,700 (35.03%)	578,336  (0.52% / 0.93%)	72,338,526 (64.97%)	62,187,451 (55.86%)	10,124,343 (9.09%)	26,732 (0.02%)	233,525,989	11,157,779 (10.02% / 17.94%)	34,384,671 (30.88% / 55.29%)	578,336  (0.52% / 0.93%)	67% - 33%	25% - 25% - 25% - 25%	17,570,560  (15.78% / 28.25%)	16,814,111  (15.10% / 27.04%)	11,264,242  (10.12% / 18.11%)	5,549,754  (4.98% / 8.92%)
L1241-SSB01-a_amanitin-16h-Hi-C-rep1	60,696,609	37,448,896 (61.70%)	0 (0.00%)	0 (0.00%)	23,247,713 (38.30%)	534,561  (0.88% / 1.51%)	37,448,896 (61.70%)	35,302,915 (58.16%)	2,120,392 (3.49%)	25,589 (0.04%)	317,650,525	642,439 (1.06% / 1.82%)	24,238,281 (39.93% / 68.66%)	534,561  (0.88% / 1.51%)	68% - 32%	25% - 25% - 25% - 25%	16,530,785  (27.24% / 46.83%)	7,707,496  (12.70% / 21.83%)	1,948,364  (3.21% / 5.52%)	5,759,040  (9.49% / 16.31%)
L1242-SSB01-a_amanitin-16h-Hi-C-rep2	67,376,168	41,980,419 (62.31%)	0 (0.00%)	0 (0.00%)	25,395,749 (37.69%)	506,919  (0.75% / 1.32%)	41,980,419 (62.31%)	38,317,943 (56.87%)	3,637,968 (5.40%)	24,508 (0.04%)	227,736,960	1,294,567 (1.92% / 3.38%)	25,551,603 (37.92% / 66.68%)	506,919  (0.75% / 1.32%)	67% - 33%	25% - 25% - 25% - 25%	16,785,702  (24.91% / 43.81%)	8,765,901  (13.01% / 22.88%)	2,733,314  (4.06% / 7.13%)	6,032,518  (8.95% / 15.74%)
L1243-SSB01-a_amanitin-24h-Hi-C-rep1	81,532,584	51,973,309 (63.75%)	0 (0.00%)	0 (0.00%)	29,559,275 (36.25%)	546,077  (0.67% / 1.17%)	51,973,309 (63.75%)	46,622,828 (57.18%)	5,321,339 (6.53%)	29,142 (0.04%)	235,898,386	3,326,620 (4.08% / 7.14%)	29,748,439 (36.49% / 63.81%)	546,077  (0.67% / 1.17%)	67% - 33%	25% - 25% - 25% - 25%	17,594,153  (21.58% / 37.74%)	12,154,286  (14.91% / 26.07%)	5,518,236  (6.77% / 11.84%)	6,635,937  (8.14% / 14.23%)
L1244-SSB01-a_amanitin-24h-Hi-C-rep2	106,381,220	67,201,838 (63.17%)	0 (0.00%)	0 (0.00%)	39,179,382 (36.83%)	366,283  (0.34% / 0.73%)	67,201,838 (63.17%)	50,345,966 (47.33%)	16,825,198 (15.82%)	30,674 (0.03%)	110,607,925	7,961,710 (7.48% / 15.81%)	28,845,306 (27.12% / 57.29%)	366,283  (0.34% / 0.73%)	65% - 35%	25% - 25% - 25% - 25%	13,249,756  (12.45% / 26.32%)	15,595,550  (14.66% / 30.98%)	10,678,732  (10.04% / 21.21%)	4,916,732  (4.62% / 9.77%)
L1245-SSB01-a_amanitin-48h-Hi-C-rep1	90,180,763	57,908,666 (64.21%)	0 (0.00%)	0 (0.00%)	32,272,097 (35.79%)	443,538  (0.49% / 0.92%)	57,908,666 (64.21%)	48,307,895 (53.57%)	9,577,507 (10.62%)	23,264 (0.03%)	155,046,434	7,236,193 (8.02% / 14.98%)	27,045,343 (29.99% / 55.99%)	443,538  (0.49% / 0.92%)	66% - 34%	25% - 25% - 25% - 25%	14,627,900  (16.22% / 30.28%)	12,417,443  (13.77% / 25.70%)	7,996,822  (8.87% / 16.55%)	4,420,494  (4.90% / 9.15%)
L1246-SSB01-a_amanitin-48h-Hi-C-rep2	78,982,528	51,911,474 (65.73%)	0 (0.00%)	0 (0.00%)	27,071,054 (34.27%)	210,086  (0.27% / 0.48%)	51,911,474 (65.73%)	43,995,721 (55.70%)	7,898,229 (10.00%)	17,524 (0.02%)	152,703,652	10,204,996 (12.92% / 23.20%)	22,153,117 (28.05% / 50.35%)	210,086  (0.27% / 0.48%)	62% - 38%	25% - 25% - 25% - 25%	10,227,616  (12.95% / 23.25%)	11,925,501  (15.10% / 27.11%)	9,688,693  (12.27% / 22.02%)	2,236,727  (2.83% / 5.08%)
L1247-SSB01-a_amanitin_high-48h-Hi-C	110,015,013	69,735,084 (63.39%)	0 (0.00%)	0 (0.00%)	40,279,929 (36.61%)	174,326  (0.16% / 0.31%)	69,735,084 (63.39%)	56,318,014 (51.19%)	13,393,513 (12.17%)	23,557 (0.02%)	157,350,902	12,904,500 (11.73% / 22.91%)	28,138,017 (25.58% / 49.96%)	174,326  (0.16% / 0.31%)	58% - 42%	25% - 25% - 25% - 25%	12,521,207  (11.38% / 22.23%)	15,616,810  (14.20% / 27.73%)	13,323,212  (12.11% / 23.66%)	2,293,491  (2.08% / 4.07%)
L1332-SSB01-a_amanitin-0h-Hi-C	50,829,756	37,723,529 (74.22%)	2,357,776 (4.64%)	900,492 (1.77%)	9,847,959 (19.37%)	4,534,936  (8.92% / 13.16%)	40,081,305 (78.85%)	34,460,229 (67.80%)	5,603,323 (11.02%)	17,753 (0.03%)	129,535,007	7,935,275 (15.61% / 23.03%)	18,824,111 (37.03% / 54.63%)	4,534,936  (8.92% / 13.16%)	67% - 33%	25% - 25% - 25% - 25%	8,856,415  (17.42% / 25.70%)	9,967,696  (19.61% / 28.93%)	6,932,955  (13.64% / 20.12%)	3,034,688  (5.97% / 8.81%)
L1333-SSB01-a_amanitin-48h-Hi-C-rep1	81,447,736	59,782,816 (73.40%)	3,375,087 (4.14%)	1,366,177 (1.68%)	16,923,656 (20.78%)	2,431,401  (2.99% / 5.71%)	63,157,903 (77.54%)	42,566,706 (52.26%)	20,573,529 (25.26%)	17,668 (0.02%)	74,443,346	11,885,421 (14.59% / 27.92%)	19,781,423 (24.29% / 46.47%)	2,431,401  (2.99% / 5.71%)	60% - 40%	25% - 25% - 25% - 25%	9,625,400  (11.82% / 22.61%)	10,156,023  (12.47% / 23.86%)	8,219,059  (10.09% / 19.31%)	1,936,888  (2.38% / 4.55%)
L1334-SSB01-a_amanitin_high-48h-Hi-C	54,507,966	38,639,101 (70.89%)	3,262,018 (5.98%)	1,352,854 (2.48%)	11,253,993 (20.65%)	657,799  (1.21% / 1.86%)	41,901,119 (76.87%)	35,392,104 (64.93%)	6,498,480 (11.92%)	10,535 (0.02%)	120,659,889	12,149,243 (22.29% / 34.33%)	15,345,286 (28.15% / 43.36%)	657,799  (1.21% / 1.86%)	53% - 47%	24% - 26% - 25% - 25%	7,954,448  (14.59% / 22.48%)	7,390,838  (13.56% / 20.88%)	6,704,651  (12.30% / 18.94%)	686,125  (1.26% / 1.94%)
L1336-SSB01-a_amanitin_high-24h-Hi-C-V2	58,747,402	43,297,876 (73.70%)	2,397,165 (4.08%)	978,958 (1.67%)	12,073,403 (20.55%)	1,670,685  (2.84% / 4.53%)	45,695,041 (77.78%)	36,911,412 (62.83%)	8,773,139 (14.93%)	10,490 (0.02%)	103,174,104	13,161,243 (22.40% / 35.66%)	15,663,160 (26.66% / 42.43%)	1,670,685  (2.84% / 4.53%)	58% - 42%	25% - 25% - 25% - 25%	7,063,048  (12.02% / 19.14%)	8,600,112  (14.64% / 23.30%)	7,507,098  (12.78% / 20.34%)	1,092,920  (1.86% / 2.96%)
L1337-SSB01-a_amanitin_high-48h-Hi-C-V2	57,996,276	44,874,904 (77.38%)	1,733,119 (2.99%)	826,564 (1.43%)	10,561,689 (18.21%)	1,466,937  (2.53% / 4.64%)	46,608,023 (80.36%)	31,591,675 (54.47%)	15,003,889 (25.87%)	12,459 (0.02%)	55,803,721	12,702,052 (21.90% / 40.21%)	11,993,319 (20.68% / 37.96%)	1,466,937  (2.53% / 4.64%)	60% - 40%	25% - 25% - 25% - 25%	4,509,911  (7.78% / 14.28%)	7,483,408  (12.90% / 23.69%)	6,557,471  (11.31% / 20.76%)	925,885  (1.60% / 2.93%)
L1344-Triptolide_time_course_0h_NT-HiC	46,067,345	27,930,426 (60.63%)	0 (0.00%)	0 (0.00%)	18,136,919 (39.37%)	400,543  (0.87% / 1.55%)	27,930,426 (60.63%)	25,875,457 (56.17%)	2,044,879 (4.44%)	10,090 (0.02%)	181,184,067	4,359,670 (9.46% / 16.85%)	14,258,229 (30.95% / 55.10%)	400,543  (0.87% / 1.55%)	74% - 26%	25% - 25% - 25% - 25%	8,705,306  (18.90% / 33.64%)	5,552,923  (12.05% / 21.46%)	3,332,771  (7.23% / 12.88%)	2,220,106  (4.82% / 8.58%)
L1346-Triptolide_time_course_8h_normal_dose-Hi-C	56,684,720	35,688,666 (62.96%)	0 (0.00%)	0 (0.00%)	20,996,054 (37.04%)	438,021  (0.77% / 1.36%)	35,688,666 (62.96%)	32,294,613 (56.97%)	3,383,813 (5.97%)	10,240 (0.02%)	176,003,081	7,091,705 (12.51% / 21.96%)	16,256,256 (28.68% / 50.34%)	438,021  (0.77% / 1.36%)	73% - 27%	25% - 25% - 25% - 25%	9,664,851  (17.05% / 29.93%)	6,591,405  (11.63% / 20.41%)	4,367,366  (7.70% / 13.52%)	2,223,978  (3.92% / 6.89%)
L1347-Triptolide_time_course_8h_high_dose-Hi-C	76,780,108	47,128,146 (61.38%)	0 (0.00%)	0 (0.00%)	29,651,962 (38.62%)	546,137  (0.71% / 1.33%)	47,128,146 (61.38%)	41,169,726 (53.62%)	5,946,542 (7.74%)	11,878 (0.02%)	170,598,200	9,139,702 (11.90% / 22.20%)	20,331,629 (26.48% / 49.38%)	546,137  (0.71% / 1.33%)	73% - 27%	25% - 25% - 25% - 25%	12,538,332  (16.33% / 30.46%)	7,793,297  (10.15% / 18.93%)	5,328,647  (6.94% / 12.94%)	2,464,576  (3.21% / 5.99%)
L1348-Triptolide_time_course_24h_NT-HiC	52,148,987	34,990,642 (67.10%)	0 (0.00%)	0 (0.00%)	17,158,345 (32.90%)	548,674  (1.05% / 1.74%)	34,990,642 (67.10%)	31,540,244 (60.48%)	3,438,370 (6.59%)	12,028 (0.02%)	166,057,825	6,979,151 (13.38% / 22.13%)	15,674,551 (30.06% / 49.70%)	548,674  (1.05% / 1.74%)	71% - 29%	25% - 25% - 25% - 25%	9,064,518  (17.38% / 28.74%)	6,610,033  (12.68% / 20.96%)	4,572,399  (8.77% / 14.50%)	2,037,564  (3.91% / 6.46%)
L1349-Triptolide_time_course_24h_normal_dose-Hi-C	80,755,354	50,902,493 (63.03%)	0 (0.00%)	0 (0.00%)	29,852,861 (36.97%)	645,018  (0.80% / 1.45%)	50,902,493 (63.03%)	44,522,766 (55.13%)	6,360,287 (7.88%)	19,440 (0.02%)	186,195,153	8,068,325 (9.99% / 18.12%)	23,917,657 (29.62% / 53.72%)	645,018  (0.80% / 1.45%)	74% - 26%	25% - 25% - 25% - 25%	14,682,269  (18.18% / 32.98%)	9,235,388  (11.44% / 20.74%)	5,978,780  (7.40% / 13.43%)	3,256,547  (4.03% / 7.31%)
L1350-Triptolide_time_course_24h_high_dose-Hi-C	72,996,951	44,263,068 (60.64%)	0 (0.00%)	0 (0.00%)	28,733,883 (39.36%)	748,084  (1.02% / 1.85%)	44,263,068 (60.64%)	40,529,205 (55.52%)	3,720,893 (5.10%)	12,970 (0.02%)	248,151,872	4,178,234 (5.72% / 10.31%)	24,403,576 (33.43% / 60.21%)	748,084  (1.02% / 1.85%)	76% - 24%	25% - 25% - 25% - 25%	17,352,686  (23.77% / 42.82%)	7,050,890  (9.66% / 17.40%)	3,608,073  (4.94% / 8.90%)	3,442,753  (4.72% / 8.49%)
L1352-Triptolide_time_course_48h_normal_dose-Hi-C	61,485,603	39,142,322 (63.66%)	0 (0.00%)	0 (0.00%)	22,343,281 (36.34%)	431,875  (0.70% / 1.20%)	39,142,322 (63.66%)	35,980,002 (58.52%)	3,152,520 (5.13%)	9,800 (0.02%)	229,650,536	7,702,460 (12.53% / 21.41%)	18,351,590 (29.85% / 51.00%)	431,875  (0.70% / 1.20%)	73% - 27%	25% - 25% - 25% - 25%	10,201,062  (16.59% / 28.35%)	8,150,528  (13.26% / 22.65%)	5,678,662  (9.24% / 15.78%)	2,471,791  (4.02% / 6.87%)
L1353-Triptolide_time_course_48h_high_dose-Hi-C	66,018,815	41,739,088 (63.22%)	0 (0.00%)	0 (0.00%)	24,279,727 (36.78%)	443,504  (0.67% / 1.18%)	41,739,088 (63.22%)	37,538,312 (56.86%)	4,191,189 (6.35%)	9,587 (0.01%)	193,583,476	9,516,859 (14.42% / 25.35%)	18,195,349 (27.56% / 48.47%)	443,504  (0.67% / 1.18%)	71% - 29%	25% - 25% - 25% - 25%	9,697,118  (14.69% / 25.83%)	8,498,231  (12.87% / 22.64%)	6,290,807  (9.53% / 16.76%)	2,207,371  (3.34% / 5.88%)
L1859-Triptolide_time_course_8h_NT_intactHi-C	66,901,271	40,530,021 (60.58%)	0 (0.00%)	0 (0.00%)	26,371,250 (39.42%)	957,338  (1.43% / 2.99%)	40,530,021 (60.58%)	31,968,558 (47.78%)	8,530,168 (12.75%)	31,295 (0.05%)	82,102,436	2,319,117 (3.47% / 7.25%)	20,405,394 (30.50% / 63.83%)	957,338  (1.43% / 2.99%)	78% - 22%	25% - 25% - 25% - 25%	11,777,718  (17.60% / 36.84%)	8,627,676  (12.90% / 26.99%)	3,085,753  (4.61% / 9.65%)	5,541,871  (8.28% / 17.34%)
L1860-NT_time_course_0h_Hi-C	63,376,846	40,874,507 (64.49%)	0 (0.00%)	0 (0.00%)	22,502,339 (35.51%)	898,376  (1.42% / 2.36%)	40,874,507 (64.49%)	38,140,767 (60.18%)	2,699,674 (4.26%)	34,066 (0.05%)	295,146,381	3,624,082 (5.72% / 9.50%)	23,998,854 (37.87% / 62.92%)	898,376  (1.42% / 2.36%)	69% - 31%	25% - 25% - 25% - 25%	14,148,277  (22.32% / 37.09%)	9,850,577  (15.54% / 25.83%)	4,476,912  (7.06% / 11.74%)	5,373,576  (8.48% / 14.09%)
L1861-NT_time_course_48h_Hi-C	50,110,006	31,160,719 (62.18%)	0 (0.00%)	0 (0.00%)	18,949,287 (37.82%)	1,005,080  (2.01% / 3.34%)	31,160,719 (62.18%)	30,052,589 (59.97%)	1,080,050 (2.16%)	28,080 (0.06%)	438,263,324	488,641 (0.98% / 1.63%)	20,240,831 (40.39% / 67.35%)	1,005,080  (2.01% / 3.34%)	72% - 28%	25% - 25% - 25% - 25%	13,072,004  (26.09% / 43.50%)	7,168,827  (14.31% / 23.85%)	2,969,228  (5.93% / 9.88%)	4,199,554  (8.38% / 13.97%)
L1862-Amanitin_time_course_48h_high_dose_Hi-C	34,285,113	20,618,163 (60.14%)	0 (0.00%)	0 (0.00%)	13,666,950 (39.86%)	869,257  (2.54% / 4.30%)	20,618,163 (60.14%)	20,194,649 (58.90%)	409,578 (1.19%)	13,936 (0.04%)	511,366,949	290,265 (0.85% / 1.44%)	13,933,089 (40.64% / 68.99%)	869,257  (2.54% / 4.30%)	76% - 24%	25% - 25% - 25% - 25%	9,590,066  (27.97% / 47.49%)	4,343,023  (12.67% / 21.51%)	1,840,009  (5.37% / 9.11%)	2,502,993  (7.30% / 12.39%)
L1863-Triptolide_time_course_48h_high_dose_Hi-C	51,692,203	30,320,330 (58.66%)	0 (0.00%)	0 (0.00%)	21,371,873 (41.34%)	1,209,401  (2.34% / 4.11%)	30,320,330 (58.66%)	29,427,655 (56.93%)	875,443 (1.69%)	17,232 (0.03%)	514,314,180	372,641 (0.72% / 1.27%)	20,258,253 (39.19% / 68.84%)	1,209,401  (2.34% / 4.11%)	76% - 24%	25% - 25% - 25% - 25%	14,483,933  (28.02% / 49.22%)	5,774,320  (11.17% / 19.62%)	2,425,431  (4.69% / 8.24%)	3,348,867  (6.48% / 11.38%)
L1864-NT_time_course_96h_washout_Hi-C	69,331,722	45,281,431 (65.31%)	0 (0.00%)	0 (0.00%)	24,050,291 (34.69%)	680,761  (0.98% / 1.64%)	45,281,431 (65.31%)	41,508,293 (59.87%)	3,745,135 (5.40%)	28,003 (0.04%)	258,102,133	3,155,267 (4.55% / 7.60%)	26,471,641 (38.18% / 63.77%)	680,761  (0.98% / 1.64%)	63% - 37%	25% - 25% - 25% - 25%	12,353,321  (17.82% / 29.76%)	14,118,320  (20.36% / 34.01%)	10,798,300  (15.57% / 26.01%)	3,319,746  (4.79% / 8.00%)
L1865-Amanitin_time_course_96h_washout_high_dose_Hi-C	45,055,806	27,634,376 (61.33%)	0 (0.00%)	0 (0.00%)	17,421,430 (38.67%)	927,469  (2.06% / 3.47%)	27,634,376 (61.33%)	26,733,985 (59.34%)	883,330 (1.96%)	17,061 (0.04%)	422,472,015	504,958 (1.12% / 1.89%)	18,126,550 (40.23% / 67.80%)	927,469  (2.06% / 3.47%)	73% - 27%	25% - 25% - 25% - 25%	11,283,311  (25.04% / 42.21%)	6,843,239  (15.19% / 25.60%)	3,809,588  (8.46% / 14.25%)	3,033,600  (6.73% / 11.35%)
L1866-Triptolide_time_course_96h_washout_high_dose_Hi-C	54,731,637	33,380,170 (60.99%)	0 (0.00%)	0 (0.00%)	21,351,467 (39.01%)	1,185,812  (2.17% / 3.67%)	33,380,170 (60.99%)	32,288,548 (58.99%)	1,067,138 (1.95%)	24,484 (0.04%)	510,122,857	595,953 (1.09% / 1.85%)	22,146,724 (40.46% / 68.59%)	1,185,812  (2.17% / 3.67%)	74% - 26%	25% - 25% - 25% - 25%	14,960,287  (27.33% / 46.33%)	7,186,437  (13.13% / 22.26%)	3,349,384  (6.12% / 10.37%)	3,837,015  (7.01% / 11.88%)
L533-Symbiodinium_27C_Hi-C	456,598,476	246,822,641 (54.06%)	2,737,182 (0.60%)	869,894 (0.19%)	206,168,759 (45.15%)	13,480,488  (2.95% / 5.86%)	249,559,823 (54.66%)	230,023,597 (50.38%)	19,478,079 (4.27%)	58,147 (0.01%)	1,513,681,189	9,333,937 (2.04% / 4.06%)	151,588,939 (33.20% / 65.90%)	13,480,488  (2.95% / 5.86%)	76% - 24%	25% - 25% - 25% - 25%	86,874,088  (19.03% / 37.77%)	64,714,851  (14.17% / 28.13%)	15,980,982  (3.50% / 6.95%)	48,733,566  (10.67% / 21.19%)
L534-Symbiodinium_34C_Hi-C	450,233,968	252,544,429 (56.09%)	4,287,612 (0.95%)	1,263,568 (0.28%)	192,138,359 (42.68%)	18,713,600  (4.16% / 7.61%)	256,832,041 (57.04%)	245,981,064 (54.63%)	10,775,862 (2.39%)	75,115 (0.02%)	2,972,681,055	7,964,005 (1.77% / 3.24%)	165,195,696 (36.69% / 67.16%)	18,713,600  (4.16% / 7.61%)	78% - 22%	25% - 25% - 25% - 25%	105,854,838  (23.51% / 43.03%)	59,340,858  (13.18% / 24.12%)	15,152,077  (3.37% / 6.16%)	44,188,629  (9.81% / 17.96%)