# species: Homo sapiens # support: EXP, IMP, ISS, ISM, TAS, IEA, IDA, IGI, ISO, IGC, NAS, IPI, IEP, ISA, RCA, IC # associations retrieved on: 2017-08-16 15:10:16-04 # gofunc built on: 2016-02-08 14:16:26.444801-05 # gene associations file: ftp://ftp.geneontology.org/pub/go/gene-associations/gene_association.goa_human.gz # revision: 12/09/2015 $ # downloaded on: 2015-12-22 08:03:12-05 # GO DAG files from: http://archive.geneontology.org/latest-full/go_201512-termdb-tables.tar.gz # downloaded on: 2015-12-22 05:43:21-05 # translation required: yes # translation info: # authority: ensembl # synergizer db built on: 2015-11-17 14:24:21.26681-05 # synergizer db built from: Ensembl Genes 82 / Metazoa Mart / Plant Mart # namespace: hgnc_symbol # coverage: 99.6% # size of "genespace": 18111 # number of attributes: 19424 # NOTE: the last record consists of all the entities in the # "genespace" that are not associated with any attribute (for # the requested support). # Original number of entities in query: 242 # Number of entities in query: 242 # Total number of entities: 18120 # Original total number of entities: 18111 # Entities not in default gene space: 9 # Total number of attributes: 19424 # Translation required: yes # Translation coverage: 0.995719 # Mode: unordered # Number of simulations: 1000 # Adjusted P-value cutoff: 0.05 # Over/under: over # Evidence codes: EXP, IMP, ISS, ISM, TAS, IEA, IDA, IGI, ISO, IGC, NAS, IPI, IEP, ISA, RCA, IC OVERREPRESENTED ATTRIBUTES N X LOD P P_adj attrib ID attrib name 4 9 1.78757104555668 3.70977616840087e-06 0.013 GO:0005832 chaperonin-containing T-complex 4 12 1.59844190851698 1.41220852447205e-05 0.039 GO:0051131 chaperone-mediated protein complex assembly 8 30 1.45888989866285 4.09515862909769e-09 <0.001 GO:0003724 RNA helicase activity 5 20 1.42633393167858 5.36568730989265e-06 0.014 GO:0004004 ATP-dependent RNA helicase activity 5 22 1.37357895476847 8.91688568831533e-06 0.023 GO:0008186 RNA-dependent ATPase activity 5 25 1.30479019259785 1.74107016263135e-05 0.045 GO:0004003 ATP-dependent DNA helicase activity 6 31 1.28426539901653 2.9685575346923e-06 0.009 GO:0010494 cytoplasmic stress granule 8 45 1.23667617523217 1.26879313718018e-07 <0.001 GO:0006986 response to unfolded protein 8 47 1.21406166097571 1.80882308022377e-07 <0.001 GO:0008026 ATP-dependent helicase activity 8 47 1.21406166097571 1.80882308022377e-07 <0.001 GO:0070035 purine NTP-dependent helicase activity 13 79 1.19745431067121 3.76669915305858e-11 <0.001 GO:0071013 catalytic step 2 spliceosome 8 52 1.16217700584304 4.08729078489495e-07 0.001 GO:0035966 response to topologically incorrect protein 8 55 1.13377034694852 6.38880133543571e-07 0.002 GO:0032392 DNA geometric change 7 49 1.12599106004369 3.70175150085387e-06 0.01 GO:0008094 DNA-dependent ATPase activity 7 50 1.11586638381878 4.2557843517423e-06 0.013 GO:0006458 'de novo' protein folding 7 50 1.11586638381878 4.2557843517423e-06 0.013 GO:0032508 DNA duplex unwinding 8 57 1.11581004397701 8.47345948661909e-07 0.002 GO:0003725 double-stranded RNA binding 12 91 1.08427975748027 3.0466060469799e-09 <0.001 GO:0051082 unfolded protein binding 12 93 1.07344047615145 3.92904458625368e-09 <0.001 GO:0071103 DNA conformation change 7 57 1.05089377917492 1.04048536614316e-05 0.031 GO:0003727 single-stranded RNA binding 97 1141 1.03343340003383 3.6108695470258e-53 <0.001 GO:0044822 poly(A) RNA binding 12 103 1.02293290230828 1.28209264340783e-08 <0.001 GO:0004386 helicase activity 7 61 1.01769120582978 1.64083390404049e-05 0.043 GO:0008135 translation factor activity, RNA binding 21 187 1.0139303547697 7.98857281566078e-14 <0.001 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 21 187 1.0139303547697 7.98857281566078e-14 <0.001 GO:0000398 mRNA splicing, via spliceosome 21 194 0.995873445891663 1.66274624788204e-13 <0.001 GO:0000375 RNA splicing, via transesterification reactions 15 141 0.980519292986106 6.83276699503035e-10 <0.001 GO:0005681 spliceosomal complex 12 121 0.944500171861133 7.93982224383896e-08 <0.001 GO:0051028 mRNA transport 10 103 0.934020809893787 1.19279904461135e-06 0.005 GO:0006364 rRNA processing 102 1502 0.933682104322356 4.63802943016642e-47 <0.001 GO:0003723 RNA binding 8 83 0.931834515930819 1.50077450673003e-05 0.041 GO:0007059 chromosome segregation 12 126 0.924986584941999 1.24543044736857e-07 <0.001 GO:0035770 ribonucleoprotein granule 11 119 0.910416754326979 5.69799405486222e-07 0.001 GO:0036464 cytoplasmic ribonucleoprotein granule 10 109 0.90686280455503 2.0100467262003e-06 0.006 GO:0016072 rRNA metabolic process 26 301 0.893265394667365 4.3310959055797e-14 <0.001 GO:0008380 RNA splicing 11 128 0.875588618562744 1.18375273231648e-06 0.005 GO:0043488 regulation of mRNA stability 12 141 0.871155438436546 4.27221763734716e-07 0.001 GO:0050657 nucleic acid transport 12 141 0.871155438436546 4.27221763734716e-07 0.001 GO:0050658 RNA transport 12 141 0.871155438436546 4.27221763734716e-07 0.001 GO:0051236 establishment of RNA localization 11 131 0.864566077705062 1.49006285508462e-06 0.005 GO:0043487 regulation of RNA stability 15 183 0.854981214265224 2.49164433465083e-08 <0.001 GO:0005694 chromosome 15 184 0.852386894376619 2.68091181864253e-08 <0.001 GO:0006457 protein folding 43 643 0.7975393825257 1.54332390531674e-18 <0.001 GO:0006396 RNA processing 10 138 0.795073805042841 1.66330766759527e-05 0.043 GO:0022618 ribonucleoprotein complex assembly 21 295 0.794146075394126 4.9783973018339e-10 <0.001 GO:0051276 chromosome organization 14 195 0.791517089457862 3.79048673713112e-07 0.001 GO:0006913 nucleocytoplasmic transport 25 357 0.791479770233265 1.45124755922059e-11 <0.001 GO:0006397 mRNA processing 12 170 0.782685788465736 3.11874604847447e-06 0.009 GO:0015931 nucleobase-containing compound transport 14 200 0.779592165961695 5.15596908489142e-07 0.001 GO:0051169 nuclear transport 48 772 0.771161807384731 2.3226472184828e-19 <0.001 GO:0005730 nucleolus 17 251 0.766358011496763 4.90620748186814e-08 <0.001 GO:0016887 ATPase activity 12 181 0.753275680481848 5.96187379986825e-06 0.016 GO:0042623 ATPase activity, coupled 36 580 0.750286243663053 1.30013558762131e-14 <0.001 GO:0030529 intracellular ribonucleoprotein complex 36 580 0.750286243663053 1.30013558762131e-14 <0.001 GO:1990904 ribonucleoprotein complex 15 246 0.71548249239091 1.16761694764063e-06 0.004 GO:0031965 nuclear membrane 25 424 0.710093141002962 5.59600309712158e-10 <0.001 GO:0000278 mitotic cell cycle 133 3577 0.708342702286087 2.85864363158538e-34 <0.001 GO:0044428 nuclear part 15 258 0.693239108879953 2.11334018526967e-06 0.006 GO:0034470 ncRNA processing 22 390 0.68563497934612 1.42697792068531e-08 <0.001 GO:0010608 posttranscriptional regulation of gene expression 29 526 0.683718304293178 1.04845982858352e-10 <0.001 GO:0016071 mRNA metabolic process 18 326 0.671484334991713 4.23703467519392e-07 0.001 GO:0016604 nuclear body 33 632 0.66360276386947 2.0421616233362e-11 <0.001 GO:0007049 cell cycle 46 928 0.658735182721517 8.23456411464187e-15 <0.001 GO:0010467 gene expression 124 3563 0.644507842375702 2.4270005832747e-28 <0.001 GO:0003676 nucleic acid binding 220 12591 0.639758222045535 6.29627851888317e-16 <0.001 GO:0044424 intracellular part 18 361 0.623946795355547 1.83991525467798e-06 0.006 GO:0051301 cell division 28 575 0.623869591468044 3.64192032013574e-09 <0.001 GO:0017111 nucleoside-triphosphatase activity 22 447 0.621756890223268 1.58227476058695e-07 <0.001 GO:0006281 DNA repair 154 5433 0.619745729715602 1.4843466111147e-27 <0.001 GO:0097159 organic cyclic compound binding 153 5367 0.619660721032267 1.46171749230972e-27 <0.001 GO:1901363 heterocyclic compound binding 34 735 0.607645317612065 2.53072156856044e-10 <0.001 GO:0006259 DNA metabolic process 28 612 0.594541058666401 1.40961336402336e-08 <0.001 GO:0016462 pyrophosphatase activity 28 614 0.593007331386938 1.5117715206758e-08 <0.001 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28 616 0.591478648523892 1.62082717190424e-08 <0.001 GO:0016817 hydrolase activity, acting on acid anhydrides 30 681 0.579248743498578 9.73383484316459e-09 <0.001 GO:1903047 mitotic cell cycle process 85 2330 0.577428715179698 3.75497449039676e-19 <0.001 GO:0043228 non-membrane-bounded organelle 85 2330 0.577428715179698 3.75497449039676e-19 <0.001 GO:0043232 intracellular non-membrane-bounded organelle 90 2523 0.575949356740342 8.73681843921737e-20 <0.001 GO:0005654 nucleoplasm 221 13372 0.56859151886549 4.01891715541797e-12 <0.001 GO:0005488 binding 41 1005 0.557729978634431 1.38468856349196e-10 <0.001 GO:0022402 cell cycle process 28 667 0.554101680431516 8.66959703523342e-08 <0.001 GO:0044427 chromosomal part 172 7465 0.550375371616807 2.91601599580817e-21 <0.001 GO:0044446 intracellular organelle part 79 2232 0.550308958504848 6.95810017654598e-17 <0.001 GO:0000166 nucleotide binding 79 2233 0.550079718088011 7.14072023784026e-17 <0.001 GO:1901265 nucleoside phosphate binding 21 519 0.529461832729286 6.8789973549224e-06 0.019 GO:0034622 cellular macromolecular complex assembly 172 7687 0.52814855502064 1.1101815664278e-19 <0.001 GO:0044422 organelle part 52 1421 0.521436207400316 1.69379627914094e-11 <0.001 GO:0005524 ATP binding 52 1458 0.508884103112673 4.37601270847576e-11 <0.001 GO:0032559 adenyl ribonucleotide binding 52 1465 0.506543433830732 5.2156557980086e-11 <0.001 GO:0030554 adenyl nucleotide binding 81 2518 0.504729943474086 6.05038012695242e-15 <0.001 GO:0036094 small molecule binding 26 689 0.501866686743633 1.92312157550361e-06 0.006 GO:0006974 cellular response to DNA damage stimulus 23 617 0.493138299679406 9.4819731817048e-06 0.029 GO:0016032 viral process 23 617 0.493138299679406 9.4819731817048e-06 0.029 GO:0044403 symbiosis, encompassing mutualism through parasitism 23 622 0.489375321828535 1.07963851825289e-05 0.031 GO:0044764 multi-organism cellular process 58 1762 0.478393354287366 6.14521749332849e-11 <0.001 GO:0032549 ribonucleoside binding 58 1769 0.47642546173236 7.18778651682536e-11 <0.001 GO:0001882 nucleoside binding 57 1749 0.471948204975239 1.38955960183701e-10 <0.001 GO:0035639 purine ribonucleoside triphosphate binding 57 1759 0.469121372231345 1.73108181758703e-10 <0.001 GO:0032550 purine ribonucleoside binding 57 1762 0.46827621986413 1.84834616418184e-10 <0.001 GO:0001883 purine nucleoside binding 58 1804 0.466692579392598 1.55146621967555e-10 <0.001 GO:0032553 ribonucleotide binding 229 15497 0.463376245504547 5.12365107423346e-06 0.013 GO:0003674 molecular_function 57 1790 0.460451583704693 3.37921418542152e-10 <0.001 GO:0032555 purine ribonucleotide binding 191 10258 0.460174348084385 1.84373123803068e-13 <0.001 GO:0005515 protein binding 25 725 0.458658018751102 1.45275321632157e-05 0.039 GO:0044419 interspecies interaction between organisms 57 1799 0.457960486280113 4.08941880098795e-10 <0.001 GO:0017076 purine nucleotide binding 101 3735 0.448912138752138 5.15398665921505e-14 <0.001 GO:0090304 nucleic acid metabolic process 117 4600 0.4467358954043 8.63440499572251e-15 <0.001 GO:0005634 nucleus 184 9826 0.430393559639877 1.34614543344542e-12 <0.001 GO:0043226 organelle 62 2123 0.424357315096208 1.47683623453958e-09 <0.001 GO:0097367 carbohydrate derivative binding 167 8353 0.419405403263495 3.66504189111403e-13 <0.001 GO:0043229 intracellular organelle 104 4142 0.412598209496138 2.27857338303758e-12 <0.001 GO:0006139 nucleobase-containing compound metabolic process 115 4802 0.406424700522294 1.50262635659e-12 <0.001 GO:0034641 cellular nitrogen compound metabolic process 120 5104 0.405633864376967 1.12384990742992e-12 <0.001 GO:0060255 regulation of macromolecule metabolic process 223 14860 0.40452203396394 4.81172785054819e-06 0.013 GO:0044464 cell part 39 1348 0.39023658268304 3.73310040201575e-06 0.013 GO:0033554 cellular response to stress 104 4325 0.387570932623986 3.60158250563698e-11 <0.001 GO:0046483 heterocycle metabolic process 36 1244 0.387074779582252 9.24976905445182e-06 0.023 GO:0044877 macromolecular complex binding 104 4343 0.38515032758869 4.66978645119663e-11 <0.001 GO:0006725 cellular aromatic compound metabolic process 105 4411 0.38348516024296 5.04316761958269e-11 <0.001 GO:0005737 cytoplasm 92 3733 0.380758655606038 2.97837733644497e-10 <0.001 GO:0051171 regulation of nitrogen compound metabolic process 117 5153 0.377914876900192 3.45263095834864e-11 <0.001 GO:0006807 nitrogen compound metabolic process 129 5942 0.374381554071964 2.90226298492838e-11 <0.001 GO:0019222 regulation of metabolic process 77 3040 0.372336589257228 5.54835589163579e-09 <0.001 GO:0005829 cytosol 133 6235 0.371575594850455 3.64274306960509e-11 <0.001 GO:0044260 cellular macromolecule metabolic process 90 3727 0.366131467731996 1.5635169712322e-09 <0.001 GO:0010468 regulation of gene expression 105 4563 0.36352968688853 4.10263773425951e-10 <0.001 GO:1901360 organic cyclic compound metabolic process 166 8875 0.360105234039021 4.07721055872112e-10 <0.001 GO:0043227 membrane-bounded organelle 79 3219 0.358303859690614 1.35129806733971e-08 <0.001 GO:0016070 RNA metabolic process 113 5074 0.358291567638079 3.80991919039964e-10 <0.001 GO:0080090 regulation of primary metabolic process 63 2469 0.356883897729112 1.82967547205335e-07 <0.001 GO:0043168 anion binding 99 4292 0.354655201315303 1.73881763861777e-09 <0.001 GO:0032991 macromolecular complex 140 6900 0.35301984212842 2.88232966082499e-10 <0.001 GO:0043170 macromolecule metabolic process 113 5155 0.348526811370057 1.05546787126906e-09 <0.001 GO:0031323 regulation of cellular metabolic process 102 4531 0.345398974391966 3.25488171721847e-09 <0.001 GO:0071840 cellular component organization or biogenesis 51 1995 0.343168943786526 3.59756856701138e-06 0.01 GO:0043933 macromolecular complex subunit organization 59 2377 0.337697344816283 1.29099281055496e-06 0.005 GO:0006996 organelle organization 144 7381 0.333845889229006 2.43667170490491e-09 <0.001 GO:0043231 intracellular membrane-bounded organelle 99 4508 0.32593330735559 2.59997657203539e-08 <0.001 GO:0016043 cellular component organization 149 7974 0.312634768270475 2.43131130237049e-08 <0.001 GO:0044237 cellular metabolic process 76 3353 0.31110196973775 8.18040043037323e-07 0.002 GO:2000112 regulation of cellular macromolecule biosynthetic process 82 3676 0.310205467247284 4.63104905972332e-07 0.001 GO:0009889 regulation of biosynthetic process 81 3632 0.308743680194568 5.73599517856317e-07 0.001 GO:0031326 regulation of cellular biosynthetic process 58 2468 0.308500561424302 9.11005891223826e-06 0.023 GO:0009892 negative regulation of metabolic process 196 12266 0.308248335132027 2.3247925353839e-06 0.006 GO:0009987 cellular process 77 3464 0.301737741677327 1.45762632040014e-06 0.005 GO:0019219 regulation of nucleobase-containing compound metabolic process 153 8404 0.301265967786615 8.41755599995148e-08 <0.001 GO:0071704 organic substance metabolic process 77 3467 0.301263380804638 1.5086851674544e-06 0.005 GO:0010556 regulation of macromolecule biosynthetic process 149 8110 0.299236891494062 9.01307296112149e-08 <0.001 GO:0044238 primary metabolic process 160 9318 0.26773812486394 2.29967033406322e-06 0.006 GO:0008152 metabolic process