# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF4517 PF15006.1 KII60210.1 - 3.4e-08 33.5 0.9 1.9e-07 31.0 0.6 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4517) MULE PF10551.4 KII60211.1 - 0.0013 18.8 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain DUF4433 PF14487.1 KII60211.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4433) DUF1955 PF09205.5 KII60211.1 - 0.058 12.9 0.1 0.092 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) Pkinase PF00069.20 KII60212.1 - 0.0003 20.0 0.0 0.00032 19.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.19 KII60214.1 - 6.8e-05 22.6 0.2 0.00013 21.6 0.1 1.5 2 0 0 2 2 2 1 SH2 domain Annexin PF00191.15 KII60215.1 - 0.027 14.3 0.1 0.052 13.4 0.1 1.5 1 0 0 1 1 1 0 Annexin COX17 PF05051.8 KII60215.1 - 0.036 14.0 0.5 0.036 14.0 0.4 1.6 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) rve PF00665.21 KII60220.1 - 4.9e-22 78.2 0.0 9.7e-22 77.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60220.1 - 7.7e-05 22.1 0.0 0.00018 20.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII60220.1 - 0.043 13.5 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease RVT_1 PF00078.22 KII60221.1 - 3.1e-20 72.4 0.0 9.5e-20 70.8 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.1 KII60221.1 - 2.2e-08 34.4 0.0 5e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII60221.1 - 8.6e-08 32.0 0.0 2.5e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII60221.1 - 6.9e-05 22.5 0.0 0.00021 21.0 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease DUF993 PF06187.6 KII60221.1 - 0.042 12.3 0.0 0.064 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF993) HTH_9 PF08221.6 KII60227.1 - 0.013 15.3 0.5 0.065 13.1 0.1 2.3 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Presenilin PF01080.12 KII60227.1 - 0.38 9.5 8.2 0.45 9.2 5.7 1.1 1 0 0 1 1 1 0 Presenilin DUF1673 PF07895.6 KII60228.1 - 0.018 14.5 1.3 0.021 14.3 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Dimer_Tnp_hAT PF05699.9 KII60230.1 - 4.8e-07 29.2 0.3 7.8e-07 28.6 0.2 1.3 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region DUF3671 PF12420.3 KII60232.1 - 0.42 10.6 5.5 23 5.0 3.3 2.2 1 1 1 2 2 2 0 Protein of unknown function Oxidored_q2 PF00420.19 KII60234.1 - 0.33 10.5 3.9 0.47 10.0 2.7 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF998 PF06197.8 KII60234.1 - 0.64 9.2 4.6 0.33 10.2 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF998) Claudin_2 PF13903.1 KII60234.1 - 0.99 9.0 4.1 1.5 8.4 2.9 1.4 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF4203 PF13886.1 KII60234.1 - 1.1 8.6 7.0 7.8 5.9 4.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4203) Tetraspannin PF00335.15 KII60234.1 - 9.9 5.3 7.5 37 3.5 5.2 2.0 1 1 0 1 1 1 0 Tetraspanin family DUF3440 PF11922.3 KII60236.1 - 0.18 11.3 1.0 0.22 11.0 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) Intein_splicing PF14890.1 KII60237.1 - 0.1 11.4 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Intein splicing domain Neuroparsin PF07327.6 KII60239.1 - 0.097 12.9 1.1 0.14 12.3 0.8 1.3 1 0 0 1 1 1 0 Neuroparsin DUF986 PF06173.7 KII60240.1 - 0.082 12.7 0.1 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF986) Tegument_dsDNA PF12818.2 KII60241.1 - 0.022 13.6 0.2 0.036 12.9 0.2 1.2 1 0 0 1 1 1 0 dsDNA viral tegument protein DUF3457 PF11939.3 KII60241.1 - 0.058 12.9 0.0 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3457) LINES_C PF14695.1 KII60241.1 - 0.11 11.7 0.2 0.29 10.4 0.1 1.7 2 0 0 2 2 2 0 Lines C-terminus rve PF00665.21 KII60242.1 - 7.7e-14 51.8 0.0 1.3e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60242.1 - 2.3e-05 23.8 0.0 5.1e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Glyco_transf_15 PF01793.11 KII60243.1 - 0.05 12.5 1.1 0.064 12.2 0.7 1.1 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase HTH_32 PF13565.1 KII60243.1 - 0.086 13.6 0.2 0.18 12.6 0.1 1.6 1 1 0 1 1 1 0 Homeodomain-like domain DUF3254 PF11630.3 KII60243.1 - 0.094 12.6 0.1 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3254) DDE_Tnp_IS1595 PF12762.2 KII60245.1 - 1.6e-19 70.2 0.0 2e-19 69.9 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain TauD PF02668.11 KII60245.1 - 0.094 12.3 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family DDE_3 PF13358.1 KII60246.1 - 2.8e-23 82.2 0.0 8.3e-23 80.7 0.0 1.8 1 1 1 2 2 2 1 DDE superfamily endonuclease DUF4070 PF13282.1 KII60247.1 - 0.016 14.7 0.4 0.16 11.5 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4070) Ribosomal_L18_c PF14204.1 KII60247.1 - 0.02 15.4 0.1 0.046 14.2 0.1 1.6 1 0 0 1 1 1 0 Ribosomal L18 C-terminal region zf-CCHC_3 PF13917.1 KII60247.1 - 0.056 13.1 9.6 0.74 9.5 0.8 2.7 1 1 1 2 2 2 0 Zinc knuckle UBN2 PF14223.1 KII60247.1 - 0.081 12.7 0.7 0.15 11.8 0.1 1.8 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type SRP54_N PF02881.14 KII60247.1 - 0.15 12.1 4.5 22 5.2 0.2 3.5 3 1 0 3 3 3 0 SRP54-type protein, helical bundle domain zf-CCHC_4 PF14392.1 KII60247.1 - 0.43 10.2 10.1 1.8 8.2 0.5 2.8 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC PF00098.18 KII60247.1 - 2.7 8.0 9.5 4.6 7.3 0.6 2.6 2 0 0 2 2 2 0 Zinc knuckle Mito_carr PF00153.22 KII60249.1 - 7.9e-17 60.7 0.0 9.1e-17 60.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein Ribosomal_L28 PF00830.14 KII60250.1 - 3.7 7.4 6.4 8.5 6.3 1.4 2.9 2 1 1 3 3 3 0 Ribosomal L28 family UQ_con PF00179.21 KII60253.1 - 6.6e-32 109.8 0.6 7.6e-32 109.6 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KII60253.1 - 0.00049 19.8 0.0 0.00058 19.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KII60253.1 - 0.0098 15.7 2.3 0.042 13.7 1.3 2.1 1 1 1 2 2 2 1 RWD domain Rep_fac_C PF08542.6 KII60253.1 - 0.11 12.5 0.0 0.11 12.4 0.0 1.4 1 1 0 1 1 1 0 Replication factor C C-terminal domain DUF912 PF06024.7 KII60254.1 - 0.46 10.5 2.8 0.66 10.0 0.0 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SeleniumBinding PF11524.3 KII60255.1 - 0.12 12.5 0.1 0.25 11.5 0.1 1.5 1 0 0 1 1 1 0 Selenium binding protein DUF771 PF05595.6 KII60255.1 - 0.35 10.7 2.9 14 5.6 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF771) HTH_32 PF13565.1 KII60259.1 - 0.001 19.7 0.1 0.002 18.8 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII60259.1 - 0.0021 18.0 0.2 0.0038 17.2 0.2 1.3 1 0 0 1 1 1 1 Transposase HTH_Tnp_IS630 PF01710.11 KII60259.1 - 0.018 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Transposase DDE_3 PF13358.1 KII60259.1 - 0.02 14.6 0.0 2.8 7.6 0.0 2.2 1 1 1 2 2 2 0 DDE superfamily endonuclease HTH_33 PF13592.1 KII60259.1 - 0.023 14.2 0.0 0.12 11.9 0.0 2.2 2 1 0 2 2 2 0 Winged helix-turn helix Arg_repressor PF01316.16 KII60259.1 - 0.04 13.4 0.4 0.06 12.8 0.3 1.3 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DUF1431 PF07248.7 KII60260.1 - 0.11 12.4 5.8 0.3 11.0 4.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1431) Glycos_transf_2 PF00535.21 KII60262.1 - 3.3e-31 108.2 0.0 7e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII60262.1 - 1.1e-11 44.9 0.0 1.6e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KII60262.1 - 2.7e-09 36.5 0.0 4.9e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 KII60262.1 - 0.0026 18.0 0.1 0.0075 16.5 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 DUF1230 PF06799.6 KII60263.1 - 0.033 14.0 0.2 0.036 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1230) DUF1772 PF08592.6 KII60263.1 - 0.076 12.7 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Pkinase PF00069.20 KII60264.1 - 2e-54 184.4 0.1 2.5e-54 184.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII60264.1 - 1.2e-28 99.8 0.0 1.7e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII60264.1 - 3.3e-07 29.5 0.0 4.2e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like CheF-arch PF04283.7 KII60264.1 - 0.068 12.3 0.2 0.19 10.9 0.1 1.7 1 1 0 1 1 1 0 Chemotaxis signal transduction system protein F from archaea Kdo PF06293.9 KII60264.1 - 0.1 11.6 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family cNMP_binding PF00027.24 KII60265.1 - 4.2e-10 39.3 0.1 8.8e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain ArsR PF09824.4 KII60265.1 - 0.0045 16.3 1.0 0.022 14.1 0.1 2.0 2 0 0 2 2 2 1 ArsR transcriptional regulator Bac_DNA_binding PF00216.16 KII60265.1 - 0.046 13.7 1.8 0.24 11.4 0.1 2.3 2 0 0 2 2 2 0 Bacterial DNA-binding protein Glyco_hydro_108 PF05838.7 KII60265.1 - 0.1 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase 108 RNase_HII PF01351.13 KII60265.1 - 0.28 10.8 2.4 0.33 10.5 1.4 1.3 1 1 0 1 1 1 0 Ribonuclease HII Dus PF01207.12 KII60268.1 - 1.3e-44 152.2 0.0 1.7e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) FMN_dh PF01070.13 KII60268.1 - 0.035 12.9 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase DHO_dh PF01180.16 KII60268.1 - 0.041 12.8 0.0 1.3 7.9 0.0 2.1 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase PAT1 PF09770.4 KII60269.1 - 1.3 7.1 11.0 1.4 7.0 7.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 zf-Di19 PF05605.7 KII60270.1 - 0.00072 19.6 3.9 0.24 11.5 0.8 2.2 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-FCS PF06467.9 KII60270.1 - 0.0013 18.2 5.4 0.057 13.0 1.0 2.4 2 0 0 2 2 2 2 MYM-type Zinc finger with FCS sequence motif zf-C2H2 PF00096.21 KII60270.1 - 0.0064 16.7 7.0 1.1 9.7 1.4 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type DUF3449 PF11931.3 KII60270.1 - 0.024 14.1 0.2 0.035 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Ima1_N PF09779.4 KII60270.1 - 0.057 13.9 2.6 1.7 9.1 1.6 2.1 1 1 1 2 2 2 0 Ima1 N-terminal domain PyrI_C PF02748.10 KII60270.1 - 0.065 12.6 3.8 0.57 9.6 0.1 2.3 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_4 PF13894.1 KII60270.1 - 0.19 12.1 6.7 3.3 8.2 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger LIM PF00412.17 KII60270.1 - 0.21 11.7 5.3 0.39 10.8 3.7 1.5 1 0 0 1 1 1 0 LIM domain zf-BED PF02892.10 KII60270.1 - 7 6.5 8.9 6.2 6.6 4.2 2.1 1 1 1 2 2 2 0 BED zinc finger Ldl_recept_a PF00057.13 KII60272.1 - 2e-39 133.2 69.1 2e-12 46.7 9.2 4.1 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A TetM_leader PF08076.6 KII60275.1 - 0.99 9.0 3.7 2 8.0 0.0 2.5 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide AT_hook PF02178.14 KII60277.1 - 0.45 10.3 4.7 1.7 8.5 3.2 2.0 1 0 0 1 1 1 0 AT hook motif DUF4580 PF15162.1 KII60278.1 - 1.8e-07 30.6 0.8 2.7e-07 30.1 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4580) Glycos_transf_1 PF00534.15 KII60278.1 - 0.071 12.5 0.2 0.27 10.6 0.1 1.8 1 1 1 2 2 2 0 Glycosyl transferases group 1 DDE_3 PF13358.1 KII60279.1 - 1.2e-16 60.7 0.0 2.8e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII60279.1 - 1.4e-09 38.0 0.0 2.4e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII60279.1 - 4e-09 35.8 0.9 3.3e-06 26.5 0.0 2.5 2 0 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII60279.1 - 4.3e-08 33.0 0.4 0.00041 20.2 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_32 PF13565.1 KII60279.1 - 4.7e-08 33.7 0.0 1.1e-07 32.5 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.13 KII60279.1 - 1.3e-05 24.9 0.5 2.4e-05 24.0 0.3 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_Tc3_2 PF01498.13 KII60279.1 - 4.1e-05 23.5 0.5 0.00068 19.6 0.0 2.4 2 0 0 2 2 2 1 Transposase HTH_24 PF13412.1 KII60279.1 - 0.00016 20.9 0.2 0.44 9.9 0.0 2.6 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_Tnp_1 PF01527.15 KII60279.1 - 0.00046 20.0 0.0 0.0025 17.7 0.0 2.2 1 1 1 2 2 2 1 Transposase HTH_38 PF13936.1 KII60279.1 - 0.00098 18.6 1.1 0.024 14.1 0.1 2.8 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_33 PF13592.1 KII60279.1 - 0.0047 16.4 0.1 0.0084 15.6 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn helix Fe_dep_repress PF01325.14 KII60279.1 - 0.032 14.1 0.0 0.09 12.7 0.0 1.7 2 0 0 2 2 1 0 Iron dependent repressor, N-terminal DNA binding domain MarR_2 PF12802.2 KII60279.1 - 0.036 13.7 0.0 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 MarR family HTH_Tnp_ISL3 PF13542.1 KII60279.1 - 0.06 12.5 0.4 6.1 6.1 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 CENP-B_N PF04218.8 KII60279.1 - 0.076 12.4 3.8 0.43 10.0 0.3 2.8 3 0 0 3 3 3 0 CENP-B N-terminal DNA-binding domain HTH_11 PF08279.7 KII60279.1 - 2 8.1 5.3 8.3 6.1 0.1 2.8 3 0 0 3 3 2 0 HTH domain Bot1p PF12298.3 KII60279.1 - 3.1 7.7 4.8 5.1 7.0 0.5 2.6 3 0 0 3 3 3 0 Eukaryotic mitochondrial regulator protein STAG PF08514.6 KII60281.1 - 0.026 14.2 0.3 0.045 13.4 0.0 1.4 2 0 0 2 2 2 0 STAG domain zf-DHHC PF01529.15 KII60282.1 - 2.7e-33 114.8 12.5 4e-33 114.2 8.6 1.3 1 1 0 1 1 1 1 DHHC palmitoyltransferase Phage_C PF12025.3 KII60284.1 - 0.33 10.9 1.4 1.1 9.2 0.2 2.0 2 0 0 2 2 2 0 Phage protein C V_ATPase_I PF01496.14 KII60285.1 - 1.4e-187 625.0 22.0 4.5e-104 348.8 10.5 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family TBPIP PF07106.8 KII60286.1 - 1.5e-13 50.6 11.1 3.9e-13 49.2 7.7 1.6 1 1 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Uds1 PF15456.1 KII60286.1 - 0.0035 17.3 1.8 0.0057 16.6 1.2 1.5 1 1 0 1 1 1 1 Up-regulated During Septation DUF964 PF06133.6 KII60286.1 - 0.013 15.5 6.5 0.02 14.9 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF964) FlxA PF14282.1 KII60286.1 - 0.031 14.2 1.5 0.031 14.2 1.1 2.4 1 1 1 2 2 2 0 FlxA-like protein Med9 PF07544.8 KII60286.1 - 0.073 12.8 0.1 0.073 12.8 0.1 1.9 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF2730 PF10805.3 KII60286.1 - 0.15 11.8 1.0 0.33 10.7 0.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) Vps51 PF08700.6 KII60286.1 - 0.16 11.8 4.1 0.16 11.8 0.2 2.5 2 1 0 2 2 2 0 Vps51/Vps67 Relaxase PF03432.9 KII60286.1 - 0.2 11.0 5.9 0.29 10.4 4.1 1.3 1 1 0 1 1 1 0 Relaxase/Mobilisation nuclease domain Lge1 PF11488.3 KII60286.1 - 0.28 11.4 3.8 0.81 9.9 2.6 1.9 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 FliD_N PF02465.13 KII60286.1 - 0.41 11.0 5.1 3.2 8.1 0.2 2.7 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus IncA PF04156.9 KII60286.1 - 0.41 10.2 4.6 0.21 11.1 1.0 1.8 1 1 0 2 2 2 0 IncA protein DUF3847 PF12958.2 KII60286.1 - 0.91 9.3 7.3 0.1 12.3 1.7 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3847) Matrilin_ccoil PF10393.4 KII60286.1 - 2.3 7.6 6.0 0.41 10.0 0.5 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Inhibitor_I29 PF08246.7 KII60287.1 - 9.1e-11 41.8 5.5 1.4e-10 41.2 3.8 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.18 KII60287.1 - 8.8e-09 35.5 0.6 1.6e-08 34.7 0.0 1.6 2 0 0 2 2 2 1 Papain family cysteine protease DUF694 PF05107.7 KII60287.1 - 0.0007 18.9 0.6 0.0011 18.2 0.3 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF694) Inhibitor_I29 PF08246.7 KII60288.1 - 1.3e-09 38.1 5.6 1.9e-09 37.6 3.9 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.18 KII60288.1 - 1.1e-08 35.3 0.7 1.6e-08 34.7 0.0 1.6 2 0 0 2 2 2 1 Papain family cysteine protease DUF694 PF05107.7 KII60288.1 - 0.0023 17.1 0.6 0.0027 16.9 0.4 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF694) Ribosomal_L30_N PF08079.7 KII60288.1 - 1.1 9.3 4.4 0.96 9.5 1.3 1.9 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain Peptidase_C1 PF00112.18 KII60291.1 - 5.2e-67 225.9 0.0 7.8e-67 225.3 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII60291.1 - 2.6e-07 30.7 2.5 4.8e-07 29.9 1.7 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KII60291.1 - 0.031 12.8 0.1 1.2 7.5 0.0 2.4 2 1 0 2 2 2 0 Peptidase C1-like family Got1 PF04178.7 KII60292.1 - 0.0036 17.3 0.3 0.0048 17.0 0.2 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family MLANA PF14991.1 KII60292.1 - 0.016 15.1 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein melan-A tRNA-synt_1 PF00133.17 KII60293.1 - 1.9e-138 462.1 0.0 2.8e-137 458.2 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 KII60293.1 - 4.3e-35 120.7 0.7 7.6e-35 119.9 0.5 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KII60293.1 - 7.1e-09 34.8 0.2 0.0013 17.4 0.0 3.9 3 1 1 4 4 4 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 KII60293.1 - 1.5e-06 27.6 0.1 0.00014 21.2 0.0 2.6 1 1 0 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.4 KII60293.1 - 0.12 12.4 1.7 0.21 11.6 1.2 1.4 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1b PF00579.20 KII60293.1 - 0.13 11.3 0.0 0.28 10.2 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) UBN2 PF14223.1 KII60295.1 - 0.05 13.3 0.0 0.06 13.1 0.0 1.2 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type HLH PF00010.21 KII60295.1 - 0.095 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain RVT_1 PF00078.22 KII60296.1 - 8.4e-18 64.5 0.2 1.7e-17 63.4 0.2 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RmuC PF02646.11 KII60297.1 - 0.04 12.7 0.1 0.059 12.2 0.1 1.2 1 0 0 1 1 1 0 RmuC family Spore_III_AF PF09581.5 KII60297.1 - 0.47 10.2 2.7 0.31 10.8 0.4 1.8 2 1 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) RVP PF00077.15 KII60299.1 - 1.7e-05 24.6 0.2 0.041 13.8 0.0 2.4 1 1 1 2 2 2 2 Retroviral aspartyl protease zf-CCHC PF00098.18 KII60299.1 - 0.00093 19.0 9.4 0.0042 16.9 0.2 3.1 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.1 KII60299.1 - 0.01 15.4 7.2 0.34 10.6 0.7 2.7 2 0 0 2 2 2 0 Zinc knuckle UBN2 PF14223.1 KII60299.1 - 0.014 15.1 0.0 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type Asp_protease_2 PF13650.1 KII60299.1 - 0.096 13.1 0.1 0.3 11.5 0.0 1.8 1 1 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII60299.1 - 0.11 12.2 0.2 0.7 9.7 0.1 2.1 1 1 1 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.1 KII60299.1 - 0.14 11.6 1.9 0.39 10.2 1.3 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger HTH_36 PF13730.1 KII60300.1 - 0.13 12.4 1.3 0.34 11.0 0.4 2.1 2 1 0 2 2 2 0 Helix-turn-helix domain RVT_1 PF00078.22 KII60302.1 - 7.1e-12 45.1 0.5 5.8e-10 38.8 0.0 2.7 1 1 2 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF483 PF04467.7 KII60311.1 - 0.028 14.5 0.1 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF483) RVT_1 PF00078.22 KII60312.1 - 1.1e-09 37.9 0.2 2.4e-09 36.8 0.1 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII60313.1 - 3e-18 66.0 0.0 4.3e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60313.1 - 0.0068 15.8 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Neil1-DNA_bind PF09292.5 KII60316.1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Endonuclease VIII-like 1, DNA bind Myb_DNA-binding PF00249.26 KII60321.1 - 2.5e-07 30.6 0.1 5.8e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KII60321.1 - 0.001 19.1 1.7 0.0029 17.6 0.0 2.6 2 1 0 2 2 2 1 Myb-like DNA-binding domain HTH_32 PF13565.1 KII60322.1 - 2.1e-10 41.2 0.6 5.4e-07 30.3 0.1 2.2 2 0 0 2 2 2 2 Homeodomain-like domain HTH_29 PF13551.1 KII60322.1 - 1.4e-08 34.8 0.4 2.9e-06 27.4 0.1 2.1 1 1 1 2 2 2 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII60322.1 - 1.8e-07 31.1 1.0 4e-06 26.7 0.0 2.7 2 1 1 3 3 3 1 Transposase HTH_28 PF13518.1 KII60322.1 - 3.6e-07 30.0 0.5 1.7e-05 24.6 0.1 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 KII60322.1 - 7.8e-07 28.5 0.2 0.00012 21.5 0.0 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_24 PF13412.1 KII60322.1 - 6.3e-06 25.4 0.1 0.011 15.1 0.0 2.4 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_Tnp_IS630 PF01710.11 KII60322.1 - 6.7e-06 25.7 0.4 1.1e-05 25.0 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_Tnp_ISL3 PF13542.1 KII60322.1 - 3.5e-05 22.8 0.0 0.001 18.2 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_DeoR PF08220.7 KII60322.1 - 0.00013 21.4 0.4 0.011 15.2 0.0 2.5 2 1 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_21 PF13276.1 KII60322.1 - 0.0077 16.2 0.1 0.042 13.8 0.0 2.3 2 1 0 2 2 2 1 HTH-like domain PAX PF00292.13 KII60322.1 - 0.0087 15.7 0.3 0.03 14.0 0.1 1.8 1 1 1 2 2 2 1 'Paired box' domain FeoC PF09012.5 KII60322.1 - 0.012 15.3 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_11 PF08279.7 KII60322.1 - 0.014 15.0 0.3 6.1 6.5 0.0 2.5 2 0 0 2 2 2 0 HTH domain CENP-B_N PF04218.8 KII60322.1 - 0.023 14.1 0.4 0.26 10.7 0.0 2.5 2 1 1 3 3 3 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.15 KII60322.1 - 0.026 14.4 0.6 0.078 12.9 0.2 1.9 2 0 0 2 2 2 0 Transposase HTH_AraC PF00165.18 KII60322.1 - 0.034 13.9 0.0 0.088 12.6 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family DUF3939 PF13075.1 KII60322.1 - 0.038 13.7 0.2 0.094 12.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3939) DUF2192 PF09958.4 KII60322.1 - 0.038 13.2 0.2 0.046 12.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2192) Rrf2 PF02082.15 KII60322.1 - 0.047 13.8 0.2 0.35 11.0 0.0 2.2 2 1 0 2 2 2 0 Transcriptional regulator Arg_repressor PF01316.16 KII60322.1 - 0.087 12.3 0.1 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_Tnp_4 PF13613.1 KII60322.1 - 0.12 11.9 0.0 0.27 10.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Terminase_5 PF06056.7 KII60322.1 - 0.15 11.6 0.5 12 5.5 0.0 2.5 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) CLAMP PF14769.1 KII60325.1 - 0.08 13.0 1.8 0.13 12.4 1.2 1.3 1 0 0 1 1 1 0 Flagellar C1a complex subunit C1a-32 DDE_Tnp_IS1595 PF12762.2 KII60330.1 - 2.1e-08 34.1 0.0 2.8e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain CfAFP PF05264.6 KII60331.1 - 8.9e-06 25.5 2.2 1.6 8.5 0.0 3.5 1 1 2 3 3 3 3 Choristoneura fumiferana antifreeze protein (CfAFP) Sigma_reg_N PF13800.1 KII60331.1 - 0.15 12.0 1.7 0.38 10.7 1.2 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Integrin_B_tail PF07965.7 KII60331.1 - 1.7 9.1 6.5 0.19 12.1 1.5 1.6 2 0 0 2 2 2 0 Integrin beta tail domain GATase_6 PF13522.1 KII60332.1 - 4.3e-05 23.4 0.0 5.2e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 KII60332.1 - 5.5e-05 22.0 0.0 6.7e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_4 PF13230.1 KII60332.1 - 0.00076 18.2 0.1 0.0008 18.1 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DUF1027 PF06265.6 KII60332.1 - 0.026 14.4 0.9 0.072 12.9 0.2 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1027) H_lectin PF09458.5 KII60333.1 - 0.089 12.4 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 H-type lectin domain Aldedh PF00171.17 KII60335.1 - 1.2e-54 185.4 0.0 1.2e-43 149.2 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family HhH-GPD PF00730.20 KII60336.1 - 2.2e-11 43.9 0.0 4.9e-11 42.8 0.0 1.6 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.1 KII60336.1 - 3.5e-10 39.3 0.0 5.5e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.18 KII60336.1 - 0.00063 19.3 0.0 0.002 17.7 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.4 KII60336.1 - 0.079 13.1 3.8 0.24 11.6 2.7 1.9 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III DDE_3 PF13358.1 KII60337.1 - 1.9e-07 30.9 0.0 4e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease RVT_1 PF00078.22 KII60338.1 - 2.5e-05 23.7 0.1 3.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L22e PF01776.12 KII60340.1 - 6.2e-38 129.2 2.2 7.7e-38 128.9 1.5 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family NMT PF01233.14 KII60340.1 - 0.00056 19.5 0.0 0.00064 19.3 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain AHS2 PF02626.10 KII60340.1 - 0.069 12.4 0.0 0.095 11.9 0.0 1.2 1 1 0 1 1 1 0 Allophanate hydrolase subunit 2 Lyase_1 PF00206.15 KII60341.1 - 3.4e-94 315.5 0.0 4.5e-94 315.1 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 KII60341.1 - 2.8e-24 84.9 0.1 5.1e-24 84.1 0.1 1.4 1 0 0 1 1 1 1 Fumarase C C-terminus LCCL PF03815.14 KII60341.1 - 0.025 14.5 0.0 0.071 13.1 0.0 1.8 1 0 0 1 1 1 0 LCCL domain DDE_3 PF13358.1 KII60342.1 - 0.00025 20.8 0.1 0.00053 19.7 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF2303 PF10065.4 KII60342.1 - 0.035 12.9 0.7 0.59 8.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2303) Tektin PF03148.9 KII60342.1 - 0.14 10.6 6.6 0.021 13.3 2.0 1.4 2 0 0 2 2 2 0 Tektin family Nup54 PF13874.1 KII60342.1 - 0.34 10.5 4.2 0.11 12.1 0.6 1.9 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 7tm_1 PF00001.16 KII60344.1 - 3.9e-16 58.9 10.3 5.6e-16 58.4 7.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.4 KII60344.1 - 1.2e-07 31.2 14.3 1.6e-07 30.7 9.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0182 PF03699.8 KII60344.1 - 0.3 8.9 6.7 0.36 8.6 4.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) DPM2 PF07297.7 KII60344.1 - 2 8.7 9.5 0.096 12.9 2.1 2.1 2 1 1 3 3 3 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF3963 PF13124.1 KII60344.1 - 7.5 6.4 12.5 2 8.2 0.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3963) Mesd PF10185.4 KII60345.1 - 1.8e-07 30.9 10.6 1e-05 25.2 7.4 2.0 1 1 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor Med6 PF04934.9 KII60345.1 - 0.051 13.1 0.2 0.074 12.5 0.1 1.4 1 1 0 1 1 1 0 MED6 mediator sub complex component G_glu_transpept PF01019.16 KII60348.1 - 3.7e-118 395.2 0.0 2.3e-108 362.8 0.0 2.0 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase YodA PF09223.6 KII60348.1 - 0.073 12.7 0.5 9.1 5.8 0.1 2.3 2 0 0 2 2 2 0 YodA lipocalin-like domain Ldl_recept_a PF00057.13 KII60351.1 - 1.8e-21 75.7 47.5 1.4e-12 47.2 9.4 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A rve PF00665.21 KII60352.1 - 3e-23 82.2 0.1 7.1e-23 80.9 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII60352.1 - 1.2e-07 31.3 0.1 3.5e-07 29.7 0.1 1.9 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII60352.1 - 0.00055 19.4 0.2 0.0013 18.2 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain FLYWCH_N PF15423.1 KII60354.1 - 0.039 14.1 0.2 0.06 13.5 0.1 1.3 1 0 0 1 1 1 0 FLYWCH-type zinc finger-containing protein Ndr PF03096.9 KII60354.1 - 0.14 10.5 0.0 0.18 10.2 0.0 1.3 1 0 0 1 1 1 0 Ndr family DUF4230 PF14014.1 KII60356.1 - 0.055 13.3 0.7 0.095 12.5 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4230) P4Ha_N PF08336.6 KII60357.1 - 3.4e-15 56.0 0.1 6.6e-15 55.1 0.0 1.5 1 1 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_1 PF00515.23 KII60357.1 - 0.063 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.1 KII60357.1 - 0.089 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat DDE_1 PF03184.14 KII60358.1 - 0.01 14.9 0.1 0.018 14.2 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Pox_F15 PF04596.7 KII60358.1 - 0.079 12.5 0.1 0.16 11.5 0.0 1.5 1 1 0 1 1 1 0 Poxvirus protein F15 Kelch_6 PF13964.1 KII60359.1 - 4.8e-16 58.1 19.1 0.00062 19.8 0.6 6.6 5 2 1 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII60359.1 - 9.5e-15 54.1 17.5 0.0065 16.2 0.2 7.0 5 2 2 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII60359.1 - 9.5e-13 47.9 12.9 0.021 14.9 0.0 7.0 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII60359.1 - 1.4e-09 37.3 27.6 0.00016 21.1 1.2 6.7 6 2 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KII60359.1 - 0.00019 21.0 11.0 0.3 10.9 0.0 5.6 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.1 KII60359.1 - 0.00049 19.9 11.1 0.24 11.4 0.2 5.2 6 0 0 6 6 6 2 Kelch motif PHD PF00628.24 KII60360.1 - 8.5e-07 28.5 9.1 8.5e-07 28.5 6.3 1.8 2 0 0 2 2 2 1 PHD-finger Bromo_TP PF07524.8 KII60360.1 - 1.1e-05 25.0 0.1 1.8e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated PHD_2 PF13831.1 KII60360.1 - 5.9e-05 22.2 2.5 0.00013 21.2 1.8 1.6 1 0 0 1 1 1 1 PHD-finger zf-RING_2 PF13639.1 KII60360.1 - 0.0013 18.5 7.4 0.0038 17.0 5.1 1.9 1 1 0 1 1 1 1 Ring finger domain Prok-RING_1 PF14446.1 KII60360.1 - 0.0014 18.3 2.6 0.0014 18.3 1.8 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 1 C1_1 PF00130.17 KII60360.1 - 0.011 15.4 2.7 0.011 15.4 1.9 1.7 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RecR PF02132.10 KII60360.1 - 0.021 14.2 2.2 0.061 12.7 1.5 1.7 1 0 0 1 1 1 0 RecR protein FYVE_2 PF02318.11 KII60360.1 - 0.11 12.4 3.7 0.26 11.2 2.5 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger zf-rbx1 PF12678.2 KII60360.1 - 0.14 12.2 4.1 0.39 10.8 2.8 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger DUF4428 PF14471.1 KII60360.1 - 7.8 6.3 10.6 2.2 8.0 2.5 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) RVT_1 PF00078.22 KII60362.1 - 8e-26 90.7 0.2 3.6e-25 88.6 0.3 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII60362.1 - 1.6e-07 31.1 0.0 3.5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII60362.1 - 2.7e-05 23.8 3.2 7e-05 22.5 2.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII60362.1 - 0.00025 21.4 0.0 0.0006 20.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_4 PF14392.1 KII60362.1 - 0.017 14.7 0.7 0.048 13.3 0.5 1.8 1 0 0 1 1 1 0 Zinc knuckle gag-asp_proteas PF13975.1 KII60362.1 - 0.02 14.6 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII60362.1 - 0.059 12.9 0.1 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP_2 PF08284.6 KII60362.1 - 0.11 12.4 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Ldl_recept_a PF00057.13 KII60363.1 - 2.4e-05 24.1 28.4 0.00014 21.6 12.5 3.3 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A CDC45 PF02724.9 KII60365.1 - 0.0019 16.3 1.3 0.0019 16.3 0.9 1.0 1 0 0 1 1 1 1 CDC45-like protein RRN3 PF05327.6 KII60365.1 - 0.91 7.5 5.5 1.1 7.2 3.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.7 KII60365.1 - 1.4 6.7 11.5 1.7 6.4 8.0 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 KII60365.1 - 3.7 6.7 12.8 4.5 6.4 8.8 1.1 1 0 0 1 1 1 0 SDA1 Nop25 PF09805.4 KII60365.1 - 4.6 7.3 11.1 6.5 6.8 7.7 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) YL1 PF05764.8 KII60365.1 - 8.5 5.9 12.6 12 5.4 8.8 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Ldl_recept_a PF00057.13 KII60366.1 - 5.4e-09 35.7 13.9 5.4e-09 35.7 9.7 2.3 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A Toxin_24 PF08094.6 KII60366.1 - 0.05 13.1 1.0 0.12 12.0 0.7 1.6 1 0 0 1 1 1 0 Conotoxin TVIIA/GS family Ldl_recept_a PF00057.13 KII60367.1 - 5.4e-09 35.7 13.9 5.4e-09 35.7 9.7 2.3 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A Toxin_24 PF08094.6 KII60367.1 - 0.05 13.1 1.0 0.12 12.0 0.7 1.6 1 0 0 1 1 1 0 Conotoxin TVIIA/GS family BNR PF02012.15 KII60368.1 - 0.16 11.9 5.6 2.3 8.4 0.0 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat DUF682 PF05081.7 KII60369.1 - 0.1 12.1 0.6 0.25 10.9 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF682) PAP_assoc PF03828.14 KII60370.1 - 0.0048 16.8 0.0 0.0062 16.4 0.0 1.3 1 0 0 1 1 1 1 Cid1 family poly A polymerase RAP PF08373.5 KII60371.1 - 0.02 14.6 0.3 0.043 13.5 0.1 1.6 2 0 0 2 2 2 0 RAP domain BNR PF02012.15 KII60372.1 - 0.00033 20.0 1.3 3.5 7.8 0.0 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII60374.1 - 4.7e-07 29.5 19.2 3.6e-05 23.5 4.7 2.9 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF3421 PF11901.3 KII60374.1 - 0.12 12.1 1.9 0.2 11.4 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3421) Usp PF00582.21 KII60376.1 - 1.7e-07 31.5 0.0 2.2e-06 27.8 0.0 2.0 1 1 0 1 1 1 1 Universal stress protein family OrfB_Zn_ribbon PF07282.6 KII60376.1 - 0.0099 15.5 0.4 0.014 14.9 0.3 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Propep_M14 PF02244.11 KII60376.1 - 0.023 14.3 0.1 0.072 12.7 0.0 1.8 1 1 0 1 1 1 0 Carboxypeptidase activation peptide BTG PF07742.7 KII60376.1 - 0.062 12.8 0.1 2.2 7.7 0.0 2.2 2 0 0 2 2 2 0 BTG family RepL PF05732.6 KII60376.1 - 0.09 11.9 2.8 0.2 10.8 0.3 2.0 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) Nuf2 PF03800.9 KII60377.1 - 2.9e-07 30.5 0.8 2.9e-07 30.5 0.5 2.0 2 1 0 2 2 2 1 Nuf2 family GAS PF13851.1 KII60377.1 - 0.0008 18.6 38.9 0.012 14.8 11.6 2.8 2 1 0 2 2 2 2 Growth-arrest specific micro-tubule binding TACC PF05010.9 KII60377.1 - 0.0012 18.6 13.3 0.0012 18.6 9.2 2.2 1 1 1 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC) AAA_13 PF13166.1 KII60377.1 - 0.0018 16.8 14.1 0.0018 16.8 9.8 2.0 1 1 1 2 2 2 2 AAA domain DUF869 PF05911.6 KII60377.1 - 0.0039 15.5 22.8 0.0052 15.0 15.8 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) APG6 PF04111.7 KII60377.1 - 0.011 14.8 28.0 0.1 11.6 6.6 2.3 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF1664 PF07889.7 KII60377.1 - 0.054 13.2 19.5 0.019 14.7 1.2 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.4 KII60377.1 - 0.093 12.5 40.5 0.08 12.8 4.1 4.7 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 KII60377.1 - 0.096 11.8 13.4 0.36 9.9 2.4 2.4 1 1 0 2 2 2 0 Reovirus sigma C capsid protein IncA PF04156.9 KII60377.1 - 1.2 8.6 33.5 5.2 6.6 14.1 3.3 1 1 1 2 2 2 0 IncA protein ERM PF00769.14 KII60377.1 - 1.4 8.3 27.9 0.016 14.7 7.3 2.6 2 1 0 2 2 2 0 Ezrin/radixin/moesin family DNA_photolyase PF00875.13 KII60377.1 - 1.7 8.3 4.1 5.7 6.6 0.4 2.8 2 1 0 3 3 3 0 DNA photolyase ADIP PF11559.3 KII60377.1 - 3.8 7.4 38.0 0.5 10.2 10.4 3.8 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding Occludin_ELL PF07303.8 KII60377.1 - 4.2 8.1 24.4 0.064 13.9 2.8 4.1 2 1 2 4 4 4 0 Occludin homology domain DUF1910 PF08928.5 KII60377.1 - 9.9 6.2 13.4 1.7 8.6 1.2 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF1910) DUF1049 PF06305.6 KII60380.1 - 0.002 17.5 1.2 0.0041 16.5 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1049) Na_H_Exchanger PF00999.16 KII60380.1 - 0.021 13.3 0.4 0.026 13.0 0.3 1.1 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family ABC2_membrane_2 PF12679.2 KII60380.1 - 0.097 11.5 0.1 0.16 10.7 0.1 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein RVT_1 PF00078.22 KII60381.1 - 4.4e-22 78.4 0.0 1.1e-21 77.2 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII60381.1 - 5.7e-08 32.5 0.0 1.4e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII60381.1 - 0.0042 17.5 0.0 0.0095 16.4 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_4 PF14392.1 KII60381.1 - 0.015 14.9 8.5 0.092 12.4 0.5 2.7 2 0 0 2 2 2 0 Zinc knuckle SH3_1 PF00018.23 KII60383.1 - 3.1e-15 55.2 0.1 6.7e-15 54.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KII60383.1 - 4.9e-15 54.8 0.1 1.1e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KII60383.1 - 1.1e-11 44.0 0.0 2.6e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain VHS PF00790.14 KII60383.1 - 6.4e-05 22.6 1.2 6.4e-05 22.6 0.9 2.2 2 0 0 2 2 2 1 VHS domain Tropomodulin PF03250.9 KII60383.1 - 0.018 14.5 1.3 1.8 8.1 0.0 2.6 2 0 0 2 2 2 0 Tropomodulin UIM PF02809.15 KII60383.1 - 0.12 12.0 0.2 0.12 12.0 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF884 PF05959.6 KII60384.1 - 0.077 12.3 0.2 0.2 10.9 0.0 1.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF884) DDE_3 PF13358.1 KII60389.1 - 0.11 12.2 0.2 0.16 11.7 0.1 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease HTH_Tnp_IS630 PF01710.11 KII60390.1 - 0.12 12.0 0.0 0.35 10.5 0.0 1.7 1 0 0 1 1 1 0 Transposase DUF4448 PF14610.1 KII60391.1 - 0.0048 16.4 0.0 0.0083 15.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) DUF912 PF06024.7 KII60391.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) LRS4 PF10422.4 KII60391.1 - 0.2 11.0 1.3 0.21 10.8 0.9 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 SNAP PF14938.1 KII60392.1 - 6.5e-05 22.2 0.7 0.00012 21.2 0.5 1.4 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PAXNEB PF05625.6 KII60394.1 - 0.12 11.1 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein DDE_Tnp_IS1595 PF12762.2 KII60395.1 - 0.00022 21.0 0.0 0.00025 20.9 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain GTP_EFTU PF00009.22 KII60396.1 - 1.4e-57 194.1 0.0 1.8e-57 193.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 KII60396.1 - 9.3e-06 25.6 0.0 2.2e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KII60396.1 - 0.0036 17.2 0.0 0.0073 16.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KII60396.1 - 0.14 11.3 0.4 3.4 6.8 0.0 2.3 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit EFG_IV PF03764.13 KII60397.1 - 2.4e-34 117.4 0.0 6.4e-34 116.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU PF00009.22 KII60397.1 - 1.8e-32 112.3 0.0 2.9e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 KII60397.1 - 9.6e-18 63.8 0.0 2.1e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 KII60397.1 - 3.7e-15 55.5 0.0 9.8e-15 54.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 KII60397.1 - 2.7e-06 27.3 0.0 6.9e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 HTH_23 PF13384.1 KII60398.1 - 2.1e-06 27.1 0.0 2.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII60398.1 - 3.5e-06 26.8 0.1 6.3e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.1 KII60398.1 - 1.7e-05 24.8 0.0 2.2e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.1 KII60398.1 - 2e-05 24.0 0.0 6.3e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.13 KII60398.1 - 0.00043 19.9 0.0 0.00051 19.7 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.1 KII60398.1 - 0.0012 18.6 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_11 PF08279.7 KII60398.1 - 0.0054 16.3 0.3 0.0082 15.7 0.2 1.3 1 0 0 1 1 1 1 HTH domain HTH_7 PF02796.10 KII60398.1 - 0.015 15.1 0.6 0.068 13.0 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.11 KII60398.1 - 0.015 14.9 0.3 0.02 14.5 0.2 1.1 1 0 0 1 1 1 0 Transposase HTH_Tnp_1 PF01527.15 KII60398.1 - 0.033 14.1 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 Transposase Sigma70_r4 PF04545.11 KII60398.1 - 0.042 13.1 0.0 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 MarR PF01047.17 KII60398.1 - 0.067 12.8 0.2 0.33 10.6 0.1 1.9 1 1 0 1 1 1 0 MarR family TrmB PF01978.14 KII60398.1 - 0.081 12.6 0.1 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sigma70_r4_2 PF08281.7 KII60398.1 - 0.16 11.4 0.1 0.46 9.9 0.0 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 Glycos_transf_2 PF00535.21 KII60400.1 - 0.0036 16.9 0.0 0.012 15.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 2 ATG27 PF09451.5 KII60402.1 - 0.079 12.1 0.0 0.087 12.0 0.0 1.1 1 0 0 1 1 1 0 Autophagy-related protein 27 DUF1327 PF07041.6 KII60406.1 - 0.0044 16.9 16.5 69 3.3 0.1 7.6 1 1 7 8 8 8 1 Protein of unknown function (DUF1327) DUF1366 PF07104.6 KII60406.1 - 0.095 12.3 5.0 27 4.4 0.0 4.2 1 1 3 5 5 5 0 Protein of unknown function (DUF1366) Interfer-bind PF09294.5 KII60408.1 - 0.063 13.3 0.7 0.11 12.5 0.5 1.5 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III HTH_9 PF08221.6 KII60409.1 - 0.013 15.3 0.5 0.065 13.1 0.1 2.3 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DnaJ PF00226.26 KII60411.1 - 2.4e-24 84.8 2.8 3.6e-24 84.2 2.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF1217 PF06748.7 KII60411.1 - 0.0076 16.3 0.2 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1217) DUF493 PF04359.9 KII60411.1 - 0.068 13.5 0.9 2.1 8.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF493) TerB-N PF13208.1 KII60412.1 - 0.16 11.3 0.8 3.4 7.0 0.0 2.1 2 0 0 2 2 2 0 TerB-N DDE_1 PF03184.14 KII60413.1 - 1.3e-19 70.2 0.0 2.4e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2840 PF11000.3 KII60414.1 - 0.07 12.6 0.1 0.092 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) DUF4474 PF14751.1 KII60415.1 - 0.01 15.0 0.3 0.012 14.8 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4474) DUF3542 PF12061.3 KII60415.1 - 0.013 14.5 0.7 0.021 13.8 0.2 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3542) DUF1016 PF06250.6 KII60415.1 - 0.05 12.5 1.6 0.055 12.4 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1016) PsbQ PF05757.6 KII60415.1 - 0.13 11.6 1.2 0.34 10.2 0.9 1.9 1 1 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) RhoGEF PF00621.15 KII60415.1 - 0.34 10.7 4.9 0.27 11.1 2.0 1.8 1 1 1 2 2 2 0 RhoGEF domain Sec8_exocyst PF04048.9 KII60415.1 - 1.1 8.8 4.8 0.44 10.1 0.4 2.0 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain LMBR1 PF04791.11 KII60415.1 - 2.1 6.8 4.0 2.5 6.5 2.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein TMF_TATA_bd PF12325.3 KII60415.1 - 2.1 8.0 6.7 0.74 9.5 1.8 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF573 PF04504.9 KII60415.1 - 2.5 8.4 6.7 1.1 9.6 2.0 1.9 1 1 1 2 2 2 0 Protein of unknown function, DUF573 GEMIN8 PF15348.1 KII60415.1 - 8.1 6.4 12.2 11 6.0 4.6 2.2 1 1 1 2 2 2 0 Gemini of Cajal bodies-associated protein 8 DDE_Tnp_IS1595 PF12762.2 KII60416.1 - 0.0034 17.2 0.6 0.005 16.6 0.4 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain BNR PF02012.15 KII60417.1 - 2e-05 23.7 0.7 0.23 11.4 0.0 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat MFS_2 PF13347.1 KII60419.1 - 3.3e-68 230.0 37.1 4.5e-68 229.6 25.7 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein DUF4605 PF15378.1 KII60419.1 - 0.056 13.1 0.3 0.056 13.1 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4605) UxaC PF02614.9 KII60420.1 - 8.6e-161 535.6 0.1 1.4e-160 534.9 0.0 1.3 1 1 0 1 1 1 1 Glucuronate isomerase UxuA PF03786.8 KII60421.1 - 1.3e-102 342.9 0.0 1.5e-102 342.7 0.0 1.0 1 0 0 1 1 1 1 D-mannonate dehydratase (UxuA) AP_endonuc_2 PF01261.19 KII60421.1 - 5.1e-07 29.1 0.1 6.6e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Acetyltransf_CG PF14542.1 KII60424.1 - 2.2e-19 69.1 0.0 3.7e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Fer4_19 PF06902.6 KII60424.1 - 7.5e-18 64.1 0.2 3.4e-17 62.0 0.0 2.0 2 0 0 2 2 2 1 Divergent 4Fe-4S mono-cluster Acetyltransf_7 PF13508.1 KII60424.1 - 4.3e-06 26.7 0.0 6.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KII60424.1 - 2.9e-05 23.9 0.0 4.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.1 KII60424.1 - 0.0039 17.0 0.0 0.0068 16.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KII60424.1 - 0.006 16.6 0.0 0.0082 16.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KII60424.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein EAL PF00563.15 KII60425.1 - 1e-46 159.3 0.2 1.2e-46 159.1 0.1 1.0 1 0 0 1 1 1 1 EAL domain Fimbrial PF00419.15 KII60426.1 - 6.3e-18 65.3 0.0 7.8e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 Fimbrial protein Fimbrial PF00419.15 KII60427.1 - 5.3e-15 55.9 10.3 5.7e-15 55.7 7.1 1.0 1 0 0 1 1 1 1 Fimbrial protein Phage_integrase PF00589.17 KII60428.1 - 8.5e-41 139.4 0.3 9.9e-41 139.2 0.2 1.1 1 0 0 1 1 1 1 Phage integrase family DUF3435 PF11917.3 KII60428.1 - 0.057 12.1 0.8 0.71 8.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3435) Phage_integrase PF00589.17 KII60429.1 - 3.3e-47 160.3 0.0 6.9e-47 159.3 0.0 1.5 1 1 1 2 2 2 1 Phage integrase family Cmc1 PF08583.5 KII60431.1 - 0.012 15.3 2.6 0.029 14.1 1.8 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF4460 PF14687.1 KII60431.1 - 0.11 12.2 0.8 0.33 10.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4460) Bunya_nucleocap PF00952.12 KII60432.1 - 0.02 14.9 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Bunyavirus nucleocapsid (N) protein RVT_1 PF00078.22 KII60433.1 - 4.4e-18 65.4 0.1 7.8e-18 64.6 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1193 PF06702.7 KII60433.1 - 0.16 11.3 0.5 5 6.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1193) RVP PF00077.15 KII60434.1 - 3e-07 30.2 0.0 1.3e-06 28.2 0.0 2.0 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII60434.1 - 6.7e-05 23.3 0.3 0.00016 22.0 0.1 1.7 2 0 0 2 2 2 1 Aspartyl protease rve PF00665.21 KII60435.1 - 1.4e-08 34.8 0.4 2.6e-08 33.9 0.1 1.6 2 0 0 2 2 2 1 Integrase core domain gag-asp_proteas PF13975.1 KII60438.1 - 0.006 16.3 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII60438.1 - 0.034 14.6 0.0 0.053 14.0 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease Actin PF00022.14 KII60442.1 - 4.7e-15 54.9 0.0 8.9e-09 34.2 0.0 2.1 1 1 1 2 2 2 2 Actin DUF1308 PF07000.6 KII60443.1 - 0.021 13.4 0.1 0.03 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) zf-CCHC PF00098.18 KII60444.1 - 7.5e-07 28.7 11.8 1.5e-05 24.6 2.3 2.5 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.15 KII60444.1 - 3.6e-05 23.6 0.1 8.7e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_4 PF14392.1 KII60444.1 - 0.022 14.4 9.4 0.082 12.5 1.1 2.6 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.9 KII60444.1 - 0.11 12.4 0.0 0.32 10.8 0.0 1.9 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_3 PF13917.1 KII60444.1 - 4.1 7.2 8.6 1.5 8.6 0.4 2.6 1 1 1 2 2 2 0 Zinc knuckle Coatomer_WDAD PF04053.9 KII60445.1 - 1.9e-76 257.6 14.3 3.5e-61 207.3 2.3 3.7 2 1 1 3 3 3 2 Coatomer WD associated region WD40 PF00400.27 KII60445.1 - 7.1e-29 98.6 13.2 1.2e-08 34.4 0.0 6.0 7 0 0 7 7 7 4 WD domain, G-beta repeat BBS2_Mid PF14783.1 KII60445.1 - 0.017 14.8 0.0 10 5.9 0.0 3.3 2 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region VHS PF00790.14 KII60447.1 - 0.031 13.9 0.2 0.041 13.5 0.2 1.2 1 0 0 1 1 1 0 VHS domain AA_permease PF00324.16 KII60449.1 - 6.4e-31 107.2 11.8 7.5e-31 106.9 8.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KII60449.1 - 1.5e-10 40.2 13.1 1.8e-10 39.9 9.1 1.0 1 0 0 1 1 1 1 Amino acid permease ATP_synt_I PF03899.10 KII60449.1 - 0.041 14.0 0.2 0.041 14.0 0.1 2.4 2 1 0 2 2 2 0 ATP synthase I chain DUF4131 PF13567.1 KII60449.1 - 0.087 12.2 0.2 0.087 12.2 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) RseC_MucC PF04246.7 KII60449.1 - 0.13 11.8 3.5 9 5.8 0.0 2.2 2 1 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Rhomboid PF01694.17 KII60449.1 - 0.16 11.9 4.9 0.18 11.8 3.1 1.5 1 1 0 1 1 1 0 Rhomboid family ATPase_gene1 PF09527.5 KII60449.1 - 0.44 10.3 6.0 2.1 8.2 0.1 3.4 2 1 1 3 3 3 0 Putative F0F1-ATPase subunit (ATPase_gene1) Claudin_2 PF13903.1 KII60449.1 - 0.46 10.1 9.9 0.75 9.4 3.4 2.3 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4293 PF14126.1 KII60449.1 - 0.57 10.0 8.8 2.1 8.2 1.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4293) ATP_synt_H PF05493.8 KII60449.1 - 2.3 8.3 12.6 8.6 6.5 3.5 2.4 2 0 0 2 2 2 0 ATP synthase subunit H AA_permease PF00324.16 KII60450.1 - 1.7e-69 234.4 25.3 2.1e-69 234.1 17.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KII60450.1 - 1.2e-22 80.0 24.4 1.4e-22 79.8 16.9 1.0 1 0 0 1 1 1 1 Amino acid permease SirB PF04247.7 KII60450.1 - 0.002 17.8 4.6 0.002 17.8 3.2 2.1 2 0 0 2 2 2 1 Invasion gene expression up-regulator, SirB LysR_substrate PF03466.15 KII60451.1 - 2.8e-26 91.9 0.0 4e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.22 KII60451.1 - 3.9e-20 71.3 2.0 7.5e-20 70.4 1.4 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.15 KII60451.1 - 0.0071 15.9 0.2 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.1 KII60451.1 - 0.036 13.4 0.0 0.076 12.4 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 KII60451.1 - 0.06 13.0 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 MarR family HTH_20 PF12840.2 KII60451.1 - 0.089 12.6 0.4 0.32 10.8 0.3 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Cys_Met_Meta_PP PF01053.15 KII60452.1 - 7.8e-94 314.0 0.0 1e-93 313.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GDC-P PF02347.11 KII60452.1 - 0.00016 20.5 0.0 0.00023 20.0 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein CobN-Mg_chel PF02514.11 KII60452.1 - 0.078 10.3 0.0 0.11 9.8 0.0 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase EamA PF00892.15 KII60453.1 - 1.6e-16 60.4 2.1 1.9e-16 60.2 1.5 1.0 1 0 0 1 1 1 1 EamA-like transporter family EmrE PF13536.1 KII60453.1 - 0.00082 19.5 1.5 0.00082 19.5 1.0 1.5 1 1 1 2 2 2 1 Multidrug resistance efflux transporter DUF606 PF04657.8 KII60453.1 - 0.11 12.5 3.7 0.14 12.2 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF606 UPF0104 PF03706.8 KII60453.1 - 0.64 9.2 6.2 1 8.5 4.3 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0104) EamA PF00892.15 KII60454.1 - 2.5e-09 37.2 11.9 2.8e-09 37.0 8.2 1.0 1 0 0 1 1 1 1 EamA-like transporter family EmrE PF13536.1 KII60454.1 - 0.093 12.9 11.4 0.12 12.6 7.9 1.1 1 0 0 1 1 1 0 Multidrug resistance efflux transporter UAA PF08449.6 KII60454.1 - 4.4 6.1 11.2 9.9 4.9 7.8 1.6 1 1 0 1 1 1 0 UAA transporter family DUF2136 PF09907.4 KII60455.1 - 1.1e-15 57.4 0.7 1.3e-15 57.1 0.1 1.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2136) DUF4296 PF14129.1 KII60455.1 - 0.095 12.8 0.4 0.21 11.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) Antirestrict PF03230.8 KII60456.1 - 5.6e-22 77.5 0.5 4.6e-19 68.2 0.0 2.1 1 1 1 2 2 2 2 Antirestriction protein SLT PF01464.15 KII60457.1 - 9.9e-21 73.4 0.0 1.2e-20 73.2 0.0 1.0 1 0 0 1 1 1 1 Transglycosylase SLT domain ArsR PF09824.4 KII60457.1 - 0.11 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 ArsR transcriptional regulator Tra_M PF05261.6 KII60458.1 - 1.7e-58 196.1 0.4 2.1e-58 195.8 0.3 1.0 1 0 0 1 1 1 1 TraM protein, DNA-binding TraL PF07178.6 KII60460.1 - 4.4e-39 132.4 1.5 4.8e-39 132.2 1.0 1.0 1 0 0 1 1 1 1 TraL protein AzlD PF05437.7 KII60460.1 - 0.068 13.1 0.1 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) TraE PF05309.6 KII60461.1 - 6.3e-75 250.4 0.1 7.1e-75 250.2 0.0 1.0 1 0 0 1 1 1 1 TraE protein DUF368 PF04018.8 KII60462.1 - 0.05 12.7 0.3 0.057 12.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF368) DUF843 PF05814.6 KII60462.1 - 0.091 12.5 0.7 0.13 12.0 0.5 1.2 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) DUF4131 PF13567.1 KII60462.1 - 0.13 11.6 0.6 0.19 11.1 0.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) COX1 PF00115.15 KII60464.1 - 0.011 14.4 0.9 0.013 14.1 0.6 1.1 1 0 0 1 1 1 0 Cytochrome C and Quinol oxidase polypeptide I HlyIII PF03006.15 KII60464.1 - 0.026 13.9 1.4 0.034 13.5 1.0 1.1 1 0 0 1 1 1 0 Haemolysin-III related Tetraspannin PF00335.15 KII60464.1 - 0.054 12.7 1.1 0.064 12.5 0.7 1.2 1 0 0 1 1 1 0 Tetraspanin family zf-CCHC_5 PF14787.1 KII60464.1 - 0.14 11.6 0.5 0.24 10.9 0.3 1.3 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Presenilin PF01080.12 KII60464.1 - 0.19 10.5 1.4 0.25 10.1 1.0 1.1 1 0 0 1 1 1 0 Presenilin DUF3754 PF12576.3 KII60464.1 - 0.63 9.6 3.2 1.8 8.2 2.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3754) DUF1218 PF06749.7 KII60464.1 - 0.8 10.1 7.2 3.1 8.3 4.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1218) DUF4212 PF13937.1 KII60464.1 - 3.1 7.8 5.5 5.9 6.9 3.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4212) PepSY_TM_3 PF13706.1 KII60464.1 - 3.7 7.0 7.4 0.11 11.9 0.6 1.8 2 0 0 2 2 2 0 PepSY-associated TM helix rve PF00665.21 KII60467.1 - 3.5e-23 81.9 0.0 4.8e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Serpin PF00079.15 KII60468.1 - 3.2e-12 46.2 0.1 4.5e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ldl_recept_a PF00057.13 KII60471.1 - 9.2e-08 31.8 12.0 9.2e-08 31.8 8.3 2.7 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF4024 PF13216.1 KII60471.1 - 4 7.3 6.6 10 5.9 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) Skp1 PF01466.14 KII60473.1 - 0.11 12.5 0.0 8.1 6.5 0.0 2.3 2 0 0 2 2 2 0 Skp1 family, dimerisation domain ANTH PF07651.11 KII60474.1 - 4.3e-27 94.5 0.9 5.3e-27 94.2 0.6 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 KII60474.1 - 0.00052 19.8 0.0 0.0026 17.6 0.0 2.1 2 0 0 2 2 2 1 ENTH domain GLYCAM-1 PF05242.6 KII60475.1 - 0.095 12.6 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) PurA PF04845.8 KII60476.1 - 0.00048 19.3 2.9 0.03 13.4 0.1 2.5 1 1 1 2 2 2 2 PurA ssDNA and RNA-binding protein CHORD PF04968.7 KII60478.1 - 1.1e-33 115.2 14.0 2e-25 88.8 2.7 2.2 2 0 0 2 2 2 2 CHORD Prok-RING_1 PF14446.1 KII60478.1 - 0.79 9.5 4.9 0.33 10.7 0.2 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 MinE PF03776.9 KII60481.1 - 0.009 15.5 0.1 0.035 13.6 0.0 2.1 1 0 0 1 1 1 1 Septum formation topological specificity factor MinE Vac14_Fab1_bd PF12755.2 KII60481.1 - 0.21 12.0 3.2 0.77 10.1 0.2 3.1 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Dimer_Tnp_hAT PF05699.9 KII60482.1 - 0.0028 17.2 0.0 0.0037 16.8 0.0 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region MCM PF00493.18 KII60483.1 - 3.9e-74 249.4 2.7 4.3e-62 209.8 0.0 2.3 1 1 1 2 2 2 2 MCM2/3/5 family AAA_5 PF07728.9 KII60483.1 - 1.4e-05 24.8 0.0 4.8e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.24 KII60483.1 - 0.0012 19.0 0.0 0.0072 16.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 KII60483.1 - 0.0048 16.0 0.2 0.14 11.2 0.0 2.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.1 KII60483.1 - 0.009 16.1 0.4 0.048 13.8 0.0 2.4 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 KII60483.1 - 0.012 15.5 0.4 0.028 14.4 0.3 1.5 1 0 0 1 1 1 0 AAA ATPase domain Phage_Treg PF04761.7 KII60483.1 - 0.013 15.2 0.1 4.4 7.1 0.0 2.7 2 0 0 2 2 2 0 Lactococcus bacteriophage putative transcription regulator Miro PF08477.8 KII60483.1 - 0.015 15.7 0.1 0.052 14.0 0.0 2.0 2 0 0 2 2 1 0 Miro-like protein Viral_helicase1 PF01443.13 KII60483.1 - 0.034 13.6 0.0 0.1 12.1 0.0 1.8 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.7 KII60483.1 - 0.038 13.0 0.0 0.11 11.5 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.17 KII60483.1 - 0.04 14.1 0.0 0.13 12.4 0.0 2.0 1 1 0 1 1 1 0 RNA helicase DUF815 PF05673.8 KII60483.1 - 0.046 12.6 0.2 0.14 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 KII60483.1 - 0.082 13.2 1.4 0.16 12.2 0.1 2.1 2 1 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.18 KII60483.1 - 0.089 12.7 0.3 0.3 11.0 0.0 2.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.1 KII60483.1 - 0.1 12.8 0.3 4.3 7.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 KII60483.1 - 0.18 11.1 0.9 0.34 10.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain RVP PF00077.15 KII60487.1 - 0.0097 15.8 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.6 KII60487.1 - 0.03 14.2 0.6 0.046 13.6 0.1 1.6 1 1 1 2 2 2 0 Retroviral aspartyl protease Asp_protease PF09668.5 KII60487.1 - 0.12 11.9 0.2 0.42 10.1 0.0 1.9 2 0 0 2 2 2 0 Aspartyl protease rve PF00665.21 KII60489.1 - 6.7e-24 84.3 0.0 3.7e-23 81.8 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII60489.1 - 4.1e-16 58.9 0.0 8.5e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII60489.1 - 4.8e-08 32.8 0.1 9.7e-08 31.8 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII60489.1 - 8.5e-05 22.3 0.0 0.0002 21.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII60489.1 - 0.00013 22.3 0.0 0.0003 21.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease rve_3 PF13683.1 KII60489.1 - 0.0028 17.1 0.0 0.0087 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII60489.1 - 3.6 7.7 10.5 0.31 11.0 2.4 2.6 2 0 0 2 2 2 0 Zinc knuckle BNR PF02012.15 KII60490.1 - 0.064 13.1 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 BNR/Asp-box repeat MULE PF10551.4 KII60494.1 - 4.9e-10 39.4 0.1 1.2e-09 38.2 0.1 1.7 1 0 0 1 1 1 1 MULE transposase domain UBA_e1_C PF09358.5 KII60494.1 - 0.041 14.0 0.1 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin-activating enzyme e1 C-terminal domain FLYWCH PF04500.11 KII60494.1 - 2.5 8.0 7.4 0.26 11.2 1.4 2.2 2 0 0 2 2 2 0 FLYWCH zinc finger domain DUF3510 PF12022.3 KII60497.1 - 0.1 12.7 0.2 0.14 12.3 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) FliG_N PF14842.1 KII60498.1 - 0.07 13.2 0.0 0.096 12.8 0.0 1.2 1 0 0 1 1 1 0 FliG N-terminal domain Tetraspannin PF00335.15 KII60500.1 - 1.4e-12 47.3 8.6 1.6e-12 47.1 6.0 1.0 1 0 0 1 1 1 1 Tetraspanin family FtsX PF02687.16 KII60500.1 - 0.0059 16.3 0.8 0.015 15.0 0.3 1.8 1 1 0 1 1 1 1 FtsX-like permease family Ldl_recept_a PF00057.13 KII60501.1 - 3.6e-07 29.9 9.8 3.6e-07 29.9 6.8 4.2 4 1 1 5 5 5 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII60501.1 - 0.0055 16.3 7.8 31 4.9 0.1 5.7 5 0 0 5 5 5 3 BNR/Asp-box repeat Serpin PF00079.15 KII60502.1 - 6.4e-53 180.2 2.2 7.2e-53 180.0 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Phenol_Hydrox PF02332.13 KII60502.1 - 0.026 13.8 0.2 0.043 13.1 0.1 1.3 1 0 0 1 1 1 0 Methane/Phenol/Toluene Hydroxylase Pox_E10 PF04805.7 KII60502.1 - 1.2 8.7 4.7 15 5.1 0.0 2.4 2 0 0 2 2 2 0 E10-like protein conserved region Alpha-L-AF_C PF06964.7 KII60504.1 - 0.045 13.5 0.0 0.085 12.6 0.0 1.5 1 1 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminus Bet_v_1 PF00407.14 KII60505.1 - 0.083 12.5 0.0 0.094 12.3 0.0 1.1 1 0 0 1 1 1 0 Pathogenesis-related protein Bet v I family Use1 PF09753.4 KII60506.1 - 3.8e-11 42.9 11.0 3.7e-10 39.6 2.8 2.1 1 1 1 2 2 2 2 Membrane fusion protein Use1 Fig1 PF12351.3 KII60506.1 - 0.21 11.4 2.4 0.33 10.8 1.2 1.7 1 1 1 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Med22 PF06179.7 KII60506.1 - 0.5 10.4 5.7 0.18 11.8 0.4 2.3 2 1 0 2 2 2 0 Surfeit locus protein 5 subunit 22 of Mediator complex Topo-VIb_trans PF09239.6 KII60507.1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Topoisomerase VI B subunit, transducer DDE_Tnp_IS1595 PF12762.2 KII60508.1 - 8.6e-12 45.1 0.0 2.3e-10 40.5 0.0 2.0 1 1 1 2 2 2 2 ISXO2-like transposase domain rve PF00665.21 KII60511.1 - 2.5e-17 63.1 0.0 3.4e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII60511.1 - 0.0016 18.2 0.0 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve_3 PF13683.1 KII60511.1 - 0.0085 15.5 0.0 0.015 14.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII60514.1 - 4.2e-12 45.8 0.3 3.8e-11 42.7 0.1 2.0 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Intein_splicing PF14890.1 KII60514.1 - 0.00097 18.1 0.1 0.001 18.0 0.0 1.0 1 0 0 1 1 1 1 Intein splicing domain DUF349 PF03993.7 KII60517.1 - 0.04 14.0 0.2 0.085 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) FAD_binding_8 PF08022.7 KII60518.1 - 0.011 15.5 0.1 0.04 13.7 0.0 1.8 1 1 0 2 2 2 0 FAD-binding domain rve_3 PF13683.1 KII60518.1 - 0.034 13.6 0.0 0.069 12.6 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain rve PF00665.21 KII60518.1 - 0.036 14.1 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain N-glycanase_C PF09113.5 KII60520.1 - 0.035 13.8 0.2 0.069 12.8 0.2 1.5 1 0 0 1 1 1 0 Peptide-N-glycosidase F, C terminal RVP PF00077.15 KII60520.1 - 0.069 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease RVT_1 PF00078.22 KII60525.1 - 2.4e-06 27.0 0.4 1.5e-05 24.4 0.3 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF659 PF04937.10 KII60526.1 - 0.13 11.7 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Dynactin_p22 PF07426.6 KII60527.1 - 0.086 12.1 0.1 0.13 11.5 0.0 1.4 1 1 0 1 1 1 0 Dynactin subunit p22 MFS_Mycoplasma PF07672.8 KII60527.1 - 0.11 11.6 0.0 0.12 11.5 0.0 1.0 1 0 0 1 1 1 0 Mycoplasma MFS transporter DUF3894 PF13033.1 KII60528.1 - 0.01 15.7 0.2 0.02 14.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3894) DUF1672 PF07901.6 KII60528.1 - 0.029 13.3 0.5 0.037 13.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Dynactin_p22 PF07426.6 KII60529.1 - 0.086 12.1 0.1 0.13 11.5 0.0 1.4 1 1 0 1 1 1 0 Dynactin subunit p22 MFS_Mycoplasma PF07672.8 KII60529.1 - 0.11 11.6 0.0 0.12 11.5 0.0 1.0 1 0 0 1 1 1 0 Mycoplasma MFS transporter DUF3894 PF13033.1 KII60530.1 - 0.01 15.7 0.2 0.02 14.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3894) DUF1672 PF07901.6 KII60530.1 - 0.029 13.3 0.5 0.037 13.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Bcr-Abl_Oligo PF09036.5 KII60532.1 - 0.076 12.9 0.4 0.19 11.6 0.1 1.9 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Cbl_N2 PF02761.9 KII60534.1 - 0.035 14.1 0.4 0.14 12.2 0.2 1.8 1 1 1 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain Laminin_EGF PF00053.19 KII60536.1 - 0.041 13.8 1.1 0.075 12.9 0.8 1.4 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) EGF_2 PF07974.8 KII60536.1 - 0.052 13.7 2.6 0.052 13.7 1.8 1.9 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.2 KII60536.1 - 0.056 13.5 4.0 0.16 12.0 2.8 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF EGF PF00008.22 KII60538.1 - 0.029 14.3 3.1 0.029 14.3 2.2 1.8 2 0 0 2 2 2 0 EGF-like domain EGF_2 PF07974.8 KII60538.1 - 0.039 14.1 6.5 0.1 12.7 4.5 1.8 1 0 0 1 1 1 0 EGF-like domain EGF_3 PF12947.2 KII60538.1 - 1.3 9.0 8.3 0.095 12.6 2.1 1.9 2 0 0 2 2 2 0 EGF domain Laminin_EGF PF00053.19 KII60538.1 - 1.5 8.7 7.1 3.1 7.8 4.9 1.6 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) EGF_MSP1_1 PF12946.2 KII60538.1 - 9.1 6.1 12.2 15 5.4 4.6 2.5 2 0 0 2 2 2 0 MSP1 EGF domain 1 hEGF PF12661.2 KII60540.1 - 0.025 14.6 2.5 0.052 13.6 1.7 1.6 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.8 KII60540.1 - 0.14 12.3 7.1 0.48 10.6 4.9 1.9 1 1 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.19 KII60540.1 - 0.26 11.2 3.3 0.32 10.9 1.8 1.6 1 1 0 1 1 1 0 Laminin EGF-like (Domains III and V) cEGF PF12662.2 KII60540.1 - 2.4 7.8 5.6 0.92 9.2 1.5 2.1 2 0 0 2 2 2 0 Complement Clr-like EGF-like Methyltransf_31 PF13847.1 KII60541.1 - 0.015 14.8 0.2 0.029 13.9 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain TLP-20 PF06088.6 KII60543.1 - 0.03 13.9 1.2 0.04 13.6 0.9 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Lipocalin PF00061.18 KII60543.1 - 0.062 13.2 1.8 0.094 12.6 1.3 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Endonuc_subdom PF09062.5 KII60546.1 - 0.0012 19.5 0.3 0.002 18.8 0.2 1.4 1 0 0 1 1 1 1 PI-PfuI Endonuclease subdomain DUF2899 PF11449.3 KII60547.1 - 0.4 9.7 1.5 0.93 8.6 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2899) End_beta_barrel PF12195.3 KII60547.1 - 2.1 8.1 13.0 3.9 7.2 1.4 3.7 2 2 1 3 3 3 0 Beta barrel domain of bacteriophage endosialidase DUF3753 PF12575.3 KII60548.1 - 0.018 14.8 0.7 0.018 14.8 0.5 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) Ldl_recept_a PF00057.13 KII60550.1 - 5.2e-06 26.2 11.6 5.2e-06 26.2 8.0 3.6 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A Nucleoporin_N PF08801.6 KII60550.1 - 0.047 12.4 0.0 0.085 11.5 0.0 1.3 1 0 0 1 1 1 0 Nup133 N terminal like FG-GAP PF01839.18 KII60551.1 - 1.7e-07 30.7 8.3 0.0021 17.6 3.9 2.4 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.1 KII60551.1 - 9.8e-07 29.0 0.5 9.8e-07 29.0 0.3 2.3 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EamA PF00892.15 KII60552.1 - 2.5e-14 53.3 36.9 2.1e-07 31.0 8.1 3.0 2 1 1 3 3 3 2 EamA-like transporter family EmrE PF13536.1 KII60552.1 - 0.0069 16.5 31.4 0.13 12.4 7.5 3.2 3 0 0 3 3 3 2 Multidrug resistance efflux transporter CAF1A PF12253.3 KII60553.1 - 6e-25 87.1 3.6 1.4e-24 85.9 2.5 1.6 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A Toxin-JAB1 PF15659.1 KII60553.1 - 0.035 14.0 1.8 0.2 11.5 0.0 2.7 3 0 0 3 3 3 0 JAB-like toxin 1 GNT-I PF03071.10 KII60555.1 - 1e-31 109.9 1.0 2.8e-31 108.5 0.7 1.6 1 1 0 1 1 1 1 GNT-I family MGAT2 PF05060.9 KII60555.1 - 1.3e-07 30.9 0.3 0.01 14.7 0.0 2.2 2 0 0 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) Glyco_transf_25 PF01755.12 KII60555.1 - 2.2e-05 24.2 0.7 3.6e-05 23.5 0.5 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Glycos_transf_2 PF00535.21 KII60555.1 - 0.0094 15.6 0.6 0.022 14.4 0.2 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 G2F PF07474.7 KII60557.1 - 0.097 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 G2F domain RVT_1 PF00078.22 KII60559.1 - 5.2e-09 35.7 0.1 7.7e-09 35.2 0.1 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_C50 PF03568.12 KII60560.1 - 0.064 11.9 0.2 0.065 11.9 0.1 1.0 1 0 0 1 1 1 0 Peptidase family C50 RVT_1 PF00078.22 KII60562.1 - 0.029 13.7 0.2 0.059 12.7 0.1 1.4 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII60563.1 - 0.034 14.2 0.0 0.071 13.2 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain rve PF00665.21 KII60564.1 - 0.00078 19.5 0.3 0.047 13.7 0.1 2.5 1 1 1 2 2 2 2 Integrase core domain DDE_1 PF03184.14 KII60565.1 - 8.5e-13 47.9 0.0 1.9e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII60565.1 - 0.0011 18.7 1.0 0.0025 17.5 0.7 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain MFS_1 PF07690.11 KII60566.1 - 6.3e-47 159.9 43.2 6.3e-47 159.9 30.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily ABC_tran PF00005.22 KII60566.1 - 1.2e-16 61.2 0.0 1.5e-09 38.2 0.0 3.8 3 1 0 3 3 3 3 ABC transporter AAA_21 PF13304.1 KII60566.1 - 9.6e-12 45.4 0.5 4.3e-06 26.8 0.1 3.7 3 0 0 3 3 3 2 AAA domain Sugar_tr PF00083.19 KII60566.1 - 1.4e-09 37.0 39.5 5.5e-09 35.1 5.6 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter AAA_29 PF13555.1 KII60566.1 - 4.8e-06 26.0 0.8 0.023 14.2 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MFS_3 PF05977.8 KII60566.1 - 4.3e-05 21.8 24.2 6.3e-05 21.2 16.8 1.1 1 0 0 1 1 1 1 Transmembrane secretion effector DnaJ_CXXCXGXG PF00684.14 KII60566.1 - 5.6e-05 23.1 2.9 0.0042 17.1 0.1 3.2 3 0 0 3 3 3 1 DnaJ central domain SMC_N PF02463.14 KII60566.1 - 0.00011 21.5 0.1 1.3 8.1 0.0 3.8 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KII60566.1 - 0.00041 20.3 0.0 0.72 9.8 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 KII60566.1 - 0.0011 19.1 0.1 7.1 6.7 0.0 3.8 5 0 0 5 5 4 0 AAA domain AAA_33 PF13671.1 KII60566.1 - 0.0017 18.2 0.1 0.54 10.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KII60566.1 - 0.0028 16.8 0.2 0.043 13.0 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_15 PF13175.1 KII60566.1 - 0.022 13.8 0.5 3.9 6.4 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain AAA_19 PF13245.1 KII60566.1 - 0.025 14.3 0.6 11 5.8 0.0 2.8 2 0 0 2 2 2 0 Part of AAA domain AAA_25 PF13481.1 KII60566.1 - 0.03 13.7 0.0 1.4 8.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain RNA12 PF10443.4 KII60566.1 - 0.059 11.8 0.1 2.2 6.6 0.0 2.1 2 0 0 2 2 2 0 RNA12 protein Viral_helicase1 PF01443.13 KII60566.1 - 0.061 12.8 0.0 2.5 7.5 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.7 KII60566.1 - 0.12 12.0 0.2 11 5.6 0.1 2.4 2 0 0 2 2 2 0 NACHT domain Miro PF08477.8 KII60566.1 - 0.21 12.0 0.0 15 6.0 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein IIGP PF05049.8 KII60566.1 - 0.31 9.8 0.6 1.5 7.5 0.0 1.9 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_23 PF13476.1 KII60566.1 - 0.37 11.0 0.4 2.8 8.2 0.2 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KII60566.1 - 2 9.2 5.7 12 6.7 0.2 2.8 2 0 0 2 2 2 0 AAA domain HpaB_N PF11794.3 KII60567.1 - 1.3e-96 323.0 0.0 1.7e-96 322.6 0.0 1.1 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal HpaB PF03241.8 KII60567.1 - 3.8e-74 247.9 0.0 5e-74 247.5 0.0 1.1 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase C terminal Chorismate_bind PF00425.13 KII60568.1 - 3.5e-45 154.3 0.0 4.8e-45 153.8 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 KII60568.1 - 1.2e-18 67.2 0.0 1.9e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 KII60568.1 - 0.0061 16.0 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 SNO PF01174.14 KII60568.1 - 0.0077 15.8 0.0 0.018 14.6 0.0 1.6 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Isochorismatase PF00857.15 KII60569.1 - 1e-34 119.9 0.0 1.1e-34 119.8 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family DAHP_synth_2 PF01474.11 KII60570.1 - 4.3e-115 384.5 0.0 1.6e-65 221.1 0.0 2.1 1 1 1 2 2 2 2 Class-II DAHP synthetase family adh_short PF00106.20 KII60570.1 - 2.3e-33 115.4 7.9 4e-33 114.7 5.5 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KII60570.1 - 3.1e-23 82.8 0.2 5e-23 82.1 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KII60570.1 - 5.8e-13 48.9 3.8 1.1e-12 48.0 2.7 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 KII60570.1 - 0.0092 14.9 0.3 0.014 14.3 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Saccharop_dh PF03435.13 KII60570.1 - 0.027 13.4 0.2 0.041 12.8 0.2 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Ldh_1_N PF00056.18 KII60570.1 - 0.038 13.8 0.2 0.15 11.8 0.1 2.0 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 KII60570.1 - 0.075 12.6 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 KII60570.1 - 0.12 11.8 0.3 0.21 11.0 0.2 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family AMP-binding PF00501.23 KII60571.1 - 2.7e-54 184.1 0.0 3.4e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KII60571.1 - 6.9e-09 36.5 0.1 1.8e-08 35.1 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.8 KII60571.1 - 0.24 9.8 0.0 0.64 8.4 0.0 1.6 2 0 0 2 2 2 0 GH3 auxin-responsive promoter AMP-binding PF00501.23 KII60572.1 - 3.9e-82 275.8 0.0 6.9e-82 275.0 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 KII60572.1 - 2.6e-32 111.9 1.1 7.4e-19 67.6 0.0 2.5 3 0 0 3 3 3 2 Condensation domain PP-binding PF00550.20 KII60572.1 - 1.4e-14 54.0 0.0 4.6e-14 52.4 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 KII60572.1 - 9e-13 48.9 0.0 2.5e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_4 PF07993.7 KII60572.1 - 6.1e-11 41.7 0.0 1.1e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein HxxPF_rpt PF13745.1 KII60572.1 - 2e-07 31.2 0.1 5.5e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 HxxPF-repeated domain Epimerase PF01370.16 KII60572.1 - 0.097 12.0 0.0 0.3 10.4 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Ribosomal_60s PF00428.14 KII60575.1 - 1.8e-17 63.4 7.2 2.1e-17 63.2 5.0 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF2420 PF10336.4 KII60577.1 - 0.048 13.2 0.1 0.087 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2420) AP4E_app_platf PF14807.1 KII60578.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.5 2 0 0 2 2 2 0 Adaptin AP4 complex epsilon appendage platform HSP20 PF00011.16 KII60579.1 - 1.3e-25 89.1 1.0 5.4e-14 51.8 0.1 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family CS PF04969.11 KII60579.1 - 0.056 14.0 0.5 6.3 7.4 0.0 2.7 2 1 0 2 2 2 0 CS domain HSP20 PF00011.16 KII60580.1 - 1.6e-25 88.8 0.7 7.2e-16 57.9 0.2 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family Ly-6_related PF06579.7 KII60580.1 - 0.079 13.1 0.1 0.17 12.0 0.0 1.6 1 1 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein Vfa1 PF08432.5 KII60581.1 - 0.16 11.9 14.8 0.061 13.3 8.1 2.0 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Protocadherin PF08374.6 KII60581.1 - 0.26 10.9 10.5 0.03 13.9 4.1 1.8 2 0 0 2 2 2 0 Protocadherin AAA_11 PF13086.1 KII60581.1 - 2.3 7.7 8.4 3.1 7.3 5.8 1.1 1 0 0 1 1 1 0 AAA domain DUF342 PF03961.8 KII60581.1 - 2.4 6.4 7.6 2.5 6.4 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Bap31 PF05529.7 KII60581.1 - 5.7 6.3 11.7 0.38 10.1 3.7 2.0 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like DEAD PF00270.24 KII60582.1 - 1.1e-06 28.2 0.0 1.4e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1253 PF06862.7 KII60583.1 - 0.084 11.2 0.0 0.095 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1253) SPC22 PF04573.7 KII60584.1 - 2e-25 88.9 0.3 2.4e-25 88.8 0.2 1.1 1 0 0 1 1 1 1 Signal peptidase subunit Homeobox_KN PF05920.6 KII60585.1 - 7.7e-14 51.1 0.2 2e-13 49.7 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 KII60585.1 - 6e-10 38.5 0.8 1.1e-09 37.7 0.5 1.4 1 0 0 1 1 1 1 Homeobox domain DUF1342 PF07072.6 KII60585.1 - 0.025 14.2 0.2 0.036 13.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) Homez PF11569.3 KII60585.1 - 0.049 12.6 0.0 0.095 11.7 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez SNARE PF05739.14 KII60586.1 - 9.6e-12 44.4 0.1 2.1e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 SNARE domain zf-C3HC4_2 PF13923.1 KII60587.1 - 2.5e-13 49.7 8.0 3.9e-13 49.1 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII60587.1 - 7.7e-12 44.6 5.4 1.1e-11 44.1 3.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KII60587.1 - 1.8e-11 43.5 5.0 2.5e-11 43.0 3.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KII60587.1 - 6.3e-11 41.9 7.8 1.1e-10 41.1 5.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KII60587.1 - 1.4e-10 40.7 5.1 2e-10 40.2 3.6 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KII60587.1 - 1.1e-07 31.4 1.2 1.7e-07 30.8 0.4 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KII60587.1 - 2.3e-06 27.3 7.6 3.4e-06 26.8 5.3 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING U-box PF04564.10 KII60587.1 - 6.6e-05 22.7 0.0 0.00019 21.3 0.0 1.7 2 0 0 2 2 1 1 U-box domain zf-rbx1 PF12678.2 KII60587.1 - 0.00052 20.0 7.0 0.0016 18.5 4.8 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger Rtf2 PF04641.7 KII60587.1 - 0.0025 17.0 0.1 0.003 16.8 0.1 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Apc11 PF12861.2 KII60587.1 - 0.0093 15.7 5.9 0.021 14.6 4.1 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.1 KII60587.1 - 0.021 14.5 4.2 0.04 13.7 2.9 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein RINGv PF12906.2 KII60587.1 - 0.023 14.7 3.5 0.1 12.6 2.5 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.1 KII60587.1 - 0.044 13.3 4.6 0.087 12.4 3.2 1.4 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 KII60587.1 - 0.051 13.1 7.9 0.14 11.7 5.5 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Nse PF11789.3 KII60587.1 - 0.063 12.8 2.9 0.1 12.1 2.0 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit GAGA PF09237.6 KII60587.1 - 0.16 11.5 0.7 3.9 7.1 0.0 2.2 2 0 0 2 2 2 0 GAGA factor zf-CCHC_2 PF13696.1 KII60587.1 - 0.3 10.5 0.0 0.3 10.5 0.0 2.3 3 0 0 3 3 2 0 Zinc knuckle zf-Di19 PF05605.7 KII60587.1 - 0.37 10.9 2.6 1.7 8.8 0.1 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding TerY-C PF15616.1 KII60587.1 - 0.4 10.6 4.5 0.57 10.1 3.1 1.2 1 0 0 1 1 1 0 TerY-C metal binding domain Baculo_IE-1 PF05290.6 KII60587.1 - 0.85 9.3 4.6 1.3 8.7 3.2 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) IBR PF01485.16 KII60587.1 - 4.9 7.0 9.5 4.2 7.3 4.5 2.3 1 1 1 2 2 2 0 IBR domain RVT_1 PF00078.22 KII60591.1 - 0.055 12.8 0.1 0.21 10.9 0.0 1.9 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) PC_rep PF01851.17 KII60593.1 - 7.5e-08 32.1 1.0 0.086 13.1 0.0 4.2 4 0 0 4 4 4 3 Proteasome/cyclosome repeat Erv26 PF04148.8 KII60594.1 - 0.012 14.9 1.2 0.012 14.9 0.9 1.8 2 0 0 2 2 2 0 Transmembrane adaptor Erv26 Sec23_trunk PF04811.10 KII60596.1 - 4.7e-42 144.0 0.3 7.7e-42 143.3 0.2 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.10 KII60596.1 - 6.8e-17 60.7 8.1 1.6e-16 59.5 5.6 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.10 KII60596.1 - 1.1e-15 56.8 0.2 2.9e-15 55.5 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 KII60596.1 - 1.7e-14 54.0 0.3 7e-14 52.1 0.2 2.2 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 KII60596.1 - 5.3e-08 32.4 0.0 1.3e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat HAP2-GCS1 PF10699.4 KII60597.1 - 1.2e-13 50.7 0.1 3.1e-13 49.4 0.1 1.8 1 0 0 1 1 1 1 Male gamete fusion factor PQQ_3 PF13570.1 KII60598.1 - 0.0019 18.3 0.4 0.1 12.9 0.0 2.7 2 0 0 2 2 2 1 PQQ-like domain EAP30 PF04157.11 KII60599.1 - 0.00021 20.5 0.0 0.00028 20.1 0.0 1.3 1 1 0 1 1 1 1 EAP30/Vps36 family LEAP-2 PF07359.6 KII60599.1 - 0.015 14.9 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) CLAG PF03805.8 KII60599.1 - 0.11 9.8 0.0 0.13 9.5 0.0 1.0 1 0 0 1 1 1 0 Cytoadherence-linked asexual protein Methyltransf_4 PF02390.12 KII60600.1 - 1.7e-40 138.1 0.2 1.9e-40 138.0 0.2 1.0 1 0 0 1 1 1 1 Putative methyltransferase Pox_MCEL PF03291.11 KII60601.1 - 0.012 14.5 0.1 0.047 12.5 0.0 1.8 2 0 0 2 2 2 0 mRNA capping enzyme Methyltransf_4 PF02390.12 KII60601.1 - 0.034 13.2 0.0 0.039 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_31 PF13847.1 KII60601.1 - 0.045 13.3 0.1 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.1 KII60601.1 - 0.063 12.9 0.2 0.12 12.0 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.20 KII60602.1 - 1.4e-16 60.4 0.0 2.6e-16 59.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII60602.1 - 8.1e-06 25.0 0.0 4.8e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase DDE_3 PF13358.1 KII60603.1 - 3e-13 49.7 0.4 3.5e-13 49.5 0.3 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Clp1 PF06807.9 KII60605.1 - 0.089 12.5 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 DDE_Tnp_IS1595 PF12762.2 KII60606.1 - 2.6e-08 33.8 0.2 7.9e-08 32.2 0.0 1.9 2 0 0 2 2 2 1 ISXO2-like transposase domain DUF3896 PF13035.1 KII60606.1 - 0.044 13.8 0.1 15 5.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) NADH_oxidored PF08040.6 KII60606.1 - 0.053 13.1 0.2 37 4.0 0.0 3.7 2 2 2 4 4 4 0 MNLL subunit OCC1 PF15506.1 KII60606.1 - 0.078 12.8 0.1 12 5.9 0.0 2.4 2 0 0 2 2 2 0 OCC1 family GRAM PF02893.15 KII60607.1 - 0.012 15.0 0.1 0.027 13.9 0.1 1.6 1 0 0 1 1 1 0 GRAM domain Serpin PF00079.15 KII60609.1 - 4.5e-42 144.5 5.3 5.2e-42 144.3 3.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.21 KII60610.1 - 8.3e-05 22.6 0.2 0.00043 20.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII60610.1 - 0.0035 16.8 0.0 0.006 16.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve PF00665.21 KII60616.1 - 3.4e-11 43.2 0.0 5e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_Zn PF02022.14 KII60616.1 - 0.033 13.6 0.2 0.9 9.0 0.1 2.4 2 0 0 2 2 2 0 Integrase Zinc binding domain Fibroin_P25 PF07294.6 KII60617.1 - 0.027 13.9 0.1 0.035 13.5 0.1 1.3 1 0 0 1 1 1 0 Fibroin P25 rve PF00665.21 KII60618.1 - 4.8e-26 91.2 0.0 1e-25 90.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII60618.1 - 0.00031 20.7 1.1 0.0025 17.7 0.0 2.7 3 0 0 3 3 3 1 DDE domain rve_3 PF13683.1 KII60618.1 - 0.0083 15.6 1.5 0.016 14.6 0.0 2.3 3 0 0 3 3 3 1 Integrase core domain WSN PF02206.13 KII60620.1 - 0.085 12.6 2.1 0.13 11.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function FliD_N PF02465.13 KII60620.1 - 0.64 10.4 5.5 0.12 12.8 0.9 1.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF2518 PF10726.4 KII60621.1 - 0.11 12.0 0.0 3 7.3 0.0 2.5 3 0 0 3 3 3 0 Protein of function (DUF2518) Serpin PF00079.15 KII60626.1 - 6.7e-36 124.2 0.7 7.6e-36 124.0 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAPc_SNAP43 PF09808.4 KII60628.1 - 0.067 12.8 0.0 0.09 12.4 0.0 1.2 1 0 0 1 1 1 0 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 PROL5-SMR PF15621.1 KII60629.1 - 0.1 13.0 10.1 0.12 12.8 0.3 2.1 2 0 0 2 2 2 0 Proline-rich submaxillary gland androgen-regulated family CST-I PF06002.7 KII60630.1 - 0.081 12.1 0.1 0.087 12.0 0.1 1.2 1 0 0 1 1 1 0 Alpha-2,3-sialyltransferase (CST-I) Hormone_6 PF00236.13 KII60631.1 - 0.026 14.3 0.6 0.026 14.3 0.4 1.6 1 1 1 2 2 2 0 Glycoprotein hormone LacI PF00356.16 KII60631.1 - 0.03 13.9 0.1 0.06 12.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family rve PF00665.21 KII60632.1 - 2.8e-25 88.7 0.0 8.7e-25 87.1 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII60632.1 - 2.2e-18 66.4 0.0 2e-17 63.2 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII60632.1 - 2.3e-06 26.9 0.1 7.1e-06 25.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RICH PF05062.7 KII60632.1 - 0.15 12.2 3.7 0.6 10.2 1.0 2.6 2 0 0 2 2 2 0 RICH domain SecA_SW PF07516.8 KII60633.1 - 0.0073 16.0 0.5 0.021 14.5 0.1 1.9 2 0 0 2 2 2 1 SecA Wing and Scaffold domain Ku PF02735.11 KII60633.1 - 0.018 14.4 1.3 0.026 13.9 0.9 1.2 1 0 0 1 1 1 0 Ku70/Ku80 beta-barrel domain DUF4085 PF13315.1 KII60633.1 - 0.025 13.9 1.8 0.042 13.2 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) rve PF00665.21 KII60635.1 - 0.00044 20.3 0.0 0.00065 19.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60635.1 - 0.064 12.7 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain His_Phos_2 PF00328.17 KII60639.1 - 6.5e-17 61.8 0.9 8.9e-17 61.4 0.6 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF4393 PF14337.1 KII60640.1 - 0.072 12.5 0.1 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4393) SNARE PF05739.14 KII60641.1 - 3.7e-06 26.5 8.4 5.4e-05 22.8 1.3 2.3 2 0 0 2 2 2 2 SNARE domain CASP_C PF08172.7 KII60641.1 - 0.0058 15.6 1.6 0.0074 15.3 1.1 1.1 1 0 0 1 1 1 1 CASP C terminal Laminin_II PF06009.7 KII60641.1 - 0.012 15.3 2.9 0.11 12.2 0.1 2.1 2 0 0 2 2 2 0 Laminin Domain II Tropomyosin PF00261.15 KII60641.1 - 0.03 13.4 7.1 0.29 10.1 1.4 2.1 2 0 0 2 2 2 0 Tropomyosin SlyX PF04102.7 KII60641.1 - 0.091 13.1 9.0 0.28 11.5 0.8 3.0 2 2 0 2 2 2 0 SlyX GerE PF00196.14 KII60641.1 - 0.093 12.0 0.6 5.3 6.4 0.2 2.9 2 1 0 2 2 2 0 Bacterial regulatory proteins, luxR family WXG100 PF06013.7 KII60641.1 - 0.12 12.4 2.7 1 9.4 0.1 2.9 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Orbi_VP5 PF00901.12 KII60641.1 - 0.14 10.2 2.7 0.51 8.4 0.2 2.0 2 0 0 2 2 2 0 Orbivirus outer capsid protein VP5 IncA PF04156.9 KII60641.1 - 0.16 11.5 10.2 0.54 9.8 0.2 2.1 2 0 0 2 2 2 0 IncA protein CorA PF01544.13 KII60641.1 - 0.18 10.8 5.0 0.34 9.8 0.4 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF4200 PF13863.1 KII60641.1 - 0.2 11.5 7.7 0.97 9.3 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Sec20 PF03908.8 KII60641.1 - 0.2 11.3 10.4 1.1 8.9 2.2 2.4 2 1 0 2 2 2 0 Sec20 DUF948 PF06103.6 KII60641.1 - 0.57 10.0 2.5 0.69 9.8 0.2 2.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.7 KII60641.1 - 0.76 10.0 6.2 2.6 8.3 0.6 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein V-SNARE_C PF12352.3 KII60641.1 - 0.96 9.5 12.1 0.82 9.7 2.5 2.3 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus APG6 PF04111.7 KII60641.1 - 1.2 8.1 8.1 2.3 7.1 0.9 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 AATF-Che1 PF13339.1 KII60641.1 - 1.8 8.7 7.2 1.9 8.6 0.9 2.2 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor TBPIP PF07106.8 KII60641.1 - 2.1 7.8 6.9 2 7.9 0.5 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1664 PF07889.7 KII60641.1 - 2.2 8.0 5.2 2.3 8.0 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ATG16 PF08614.6 KII60641.1 - 4.2 7.1 10.6 2.3 7.9 1.2 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Glyco_transf_52 PF07922.6 KII60644.1 - 0.08 11.9 0.6 0.089 11.8 0.4 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 52 LCAT PF02450.10 KII60645.1 - 2.1e-10 40.1 0.0 2.2e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF3437 PF11919.3 KII60645.1 - 0.063 13.0 0.0 0.19 11.4 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3437) adh_short PF00106.20 KII60647.1 - 1.3e-17 64.2 0.0 2.4e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KII60647.1 - 3e-08 33.7 0.0 5.3e-08 32.9 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KII60647.1 - 2.3e-05 24.1 0.0 5.6e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 KR domain AdoHcyase_NAD PF00670.16 KII60647.1 - 0.014 15.2 0.2 0.023 14.5 0.1 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Shikimate_DH PF01488.15 KII60647.1 - 0.079 13.0 0.2 0.32 11.0 0.1 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 KII60647.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 NADH(P)-binding DDE_3 PF13358.1 KII60648.1 - 1.8e-12 47.2 0.0 1.9e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease SCRL PF06876.7 KII60651.1 - 0.029 14.3 0.2 0.041 13.8 0.1 1.2 1 0 0 1 1 1 0 Plant self-incompatibility response (SCRL) protein PurA PF04845.8 KII60656.1 - 1.1e-07 31.1 1.1 6.8e-06 25.3 0.2 2.2 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein FtsQ PF03799.10 KII60659.1 - 0.057 13.6 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Cell division protein FtsQ Chlor_dismutase PF06778.7 KII60659.1 - 1.6 8.4 4.5 7.3 6.2 3.1 1.8 1 1 1 2 2 2 0 Chlorite dismutase BNR PF02012.15 KII60660.1 - 0.0052 16.4 0.0 6.7 6.9 0.0 3.1 2 0 0 2 2 2 2 BNR/Asp-box repeat DUF2441 PF10386.4 KII60661.1 - 0.099 12.6 0.1 0.2 11.7 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2441) DUF1301 PF06979.7 KII60664.1 - 0.013 15.6 0.5 0.02 15.0 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1301) rve PF00665.21 KII60668.1 - 4.8e-14 52.4 0.0 8.2e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60668.1 - 0.00079 18.9 0.1 0.0017 17.8 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain DUF600 PF04634.7 KII60669.1 - 0.059 13.3 3.9 0.33 10.9 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF600 RNA_pol_Rpb8 PF03870.10 KII60671.1 - 1.4e-43 148.3 0.3 1.6e-43 148.1 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 SIS PF01380.17 KII60673.1 - 1.3e-38 131.5 0.1 4.8e-22 77.9 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 KII60673.1 - 8.1e-20 70.8 1.2 7.2e-16 57.8 0.1 2.2 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 KII60673.1 - 8.1e-14 51.7 0.0 2.2e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 KII60673.1 - 7.4e-09 34.6 0.1 1.2e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_7 PF13537.1 KII60673.1 - 1.3e-06 28.1 0.0 3.3e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.1 KII60673.1 - 0.012 15.2 0.0 0.038 13.7 0.0 1.9 1 0 0 1 1 1 0 SIS domain EGF_2 PF07974.8 KII60674.1 - 0.0019 18.3 11.0 0.0019 18.3 7.6 3.4 3 1 0 3 3 3 2 EGF-like domain hEGF PF12661.2 KII60674.1 - 0.004 17.1 33.2 0.099 12.7 2.0 5.3 6 0 0 6 6 6 3 Human growth factor-like EGF Laminin_EGF PF00053.19 KII60674.1 - 0.53 10.2 33.8 21 5.1 14.3 3.3 1 1 1 2 2 2 0 Laminin EGF-like (Domains III and V) EGF PF00008.22 KII60674.1 - 2.1 8.3 31.3 0.22 11.5 1.4 3.9 3 2 0 3 3 3 0 EGF-like domain EGF_2 PF07974.8 KII60675.1 - 0.25 11.5 41.6 0.085 13.0 7.3 3.9 3 1 0 3 3 3 0 EGF-like domain hEGF PF12661.2 KII60675.1 - 0.28 11.3 28.1 0.087 12.9 1.6 4.2 4 0 0 4 4 4 0 Human growth factor-like EGF Conotoxin PF02950.12 KII60677.1 - 0.016 15.9 5.9 0.041 14.6 4.1 1.7 1 1 0 1 1 1 0 Conotoxin Baculo_11_kDa PF06143.6 KII60677.1 - 0.055 12.8 1.7 0.48 9.8 0.4 2.2 2 0 0 2 2 2 0 Baculovirus 11 kDa family TMEM61 PF15105.1 KII60677.1 - 0.061 12.8 0.1 0.093 12.2 0.1 1.2 1 0 0 1 1 1 0 TMEM61 protein family Head_binding PF09008.5 KII60679.1 - 5.2e-12 45.8 0.6 3 7.9 0.0 5.3 5 0 0 5 5 5 5 Head binding Nucleoplasmin PF03066.10 KII60679.1 - 2.3e-09 36.9 0.0 2.3e-09 36.9 0.0 2.3 2 1 0 2 2 2 1 Nucleoplasmin Sda PF08970.5 KII60679.1 - 0.28 10.6 10.7 72 2.9 0.0 5.7 6 0 0 6 6 6 0 Sporulation inhibitor A DUF2149 PF09919.4 KII60679.1 - 5.9 7.0 17.2 95 3.1 0.1 5.8 1 1 1 6 6 6 0 Uncharacterized conserved protein (DUF2149) GSHPx PF00255.14 KII60680.1 - 5.9e-19 67.4 0.2 1e-18 66.6 0.1 1.5 1 1 0 1 1 1 1 Glutathione peroxidase Epimerase PF01370.16 KII60681.1 - 1.8e-14 53.7 0.0 4.3e-14 52.5 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KII60681.1 - 4.8e-09 35.3 0.0 9.3e-07 27.8 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 KII60681.1 - 6.3e-07 29.5 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 KII60681.1 - 7.2e-06 25.0 0.0 1.8e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain Saccharop_dh PF03435.13 KII60681.1 - 0.00018 20.6 0.0 0.00029 19.9 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase adh_short PF00106.20 KII60681.1 - 0.00022 21.2 0.0 0.00056 19.8 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 KII60681.1 - 0.0038 16.1 0.2 0.098 11.5 0.0 2.8 1 1 1 2 2 2 1 Male sterility protein DUF1731 PF08338.6 KII60681.1 - 0.004 16.6 0.1 0.0071 15.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) KR PF08659.5 KII60681.1 - 0.016 14.8 0.0 0.05 13.2 0.0 1.8 1 1 0 1 1 1 0 KR domain DUF3798 PF12683.2 KII60681.1 - 0.024 13.7 0.1 0.042 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) UPF1_Zn_bind PF09416.5 KII60681.1 - 0.035 13.6 0.0 0.09 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) Toxin_53 PF15532.1 KII60681.1 - 0.061 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative toxin 53 Maelstrom PF13017.1 KII60682.1 - 2.7e-23 82.6 0.1 4.5e-23 81.8 0.1 1.3 1 0 0 1 1 1 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.5 KII60682.1 - 0.00078 19.7 0.5 0.0026 18.1 0.3 1.8 1 0 0 1 1 1 1 HMG-box domain DUF4499 PF14934.1 KII60684.1 - 0.98 9.4 8.8 1.8 8.5 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4499) 7tm_7 PF08395.7 KII60684.1 - 1.5 7.7 23.8 0.14 11.1 3.3 2.0 1 1 1 2 2 2 0 7tm Chemosensory receptor DDE_3 PF13358.1 KII60685.1 - 1.2e-08 34.7 0.1 2e-08 34.1 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease KdgM PF06178.8 KII60686.1 - 2e-65 220.3 9.8 2.2e-65 220.1 6.8 1.0 1 0 0 1 1 1 1 Oligogalacturonate-specific porin protein (KdgM) DUF4369 PF14289.1 KII60686.1 - 0.007 16.3 0.1 0.036 14.1 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4369) TonB_dep_Rec PF00593.19 KII60686.1 - 0.023 14.6 9.1 0.028 14.3 6.3 1.1 1 0 0 1 1 1 0 TonB dependent receptor OMP_b-brl PF13505.1 KII60686.1 - 0.042 13.7 12.8 0.56 10.1 8.6 2.5 1 1 0 1 1 1 0 Outer membrane protein beta-barrel domain GerE PF00196.14 KII60687.1 - 5.3e-10 38.4 0.0 1.1e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_38 PF13936.1 KII60687.1 - 1.6e-05 24.3 0.2 0.00024 20.5 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.7 KII60687.1 - 0.00044 19.6 0.1 0.00087 18.7 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.1 KII60687.1 - 0.00054 19.0 0.0 0.00093 18.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.1 KII60687.1 - 0.0007 19.5 0.0 0.0022 17.9 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4 PF04545.11 KII60687.1 - 0.0012 18.0 2.0 0.0018 17.5 0.4 2.0 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_23 PF13384.1 KII60687.1 - 0.0021 17.6 0.4 0.0052 16.3 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain LacI PF00356.16 KII60687.1 - 0.019 14.6 0.1 0.036 13.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family MarR_2 PF12802.2 KII60687.1 - 0.027 14.1 0.2 0.19 11.4 0.1 2.1 2 0 0 2 2 2 0 MarR family SAP PF02037.22 KII60687.1 - 0.03 13.8 0.2 0.061 12.8 0.1 1.5 1 0 0 1 1 1 0 SAP domain HTH_7 PF02796.10 KII60687.1 - 0.052 13.4 0.0 0.099 12.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase GIDA_assoc_3 PF13932.1 KII60687.1 - 0.054 13.5 0.1 0.13 12.3 0.1 1.8 1 1 0 1 1 1 0 GidA associated domain 3 CDT1 PF08839.6 KII60687.1 - 0.11 12.3 0.0 0.27 11.1 0.0 1.6 1 1 1 2 2 2 0 DNA replication factor CDT1 like HTH_29 PF13551.1 KII60687.1 - 0.13 12.4 0.1 0.53 10.4 0.1 2.0 2 0 0 2 2 2 0 Winged helix-turn helix Med26 PF08711.6 KII60688.1 - 7.9e-06 25.2 0.7 1.9e-05 24.1 0.5 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain LEDGF PF11467.3 KII60688.1 - 0.068 12.8 0.3 0.12 12.1 0.2 1.5 1 1 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) TCL1_MTCP1 PF01840.12 KII60692.1 - 0.043 13.3 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 TCL1/MTCP1 family Meiosis_expr PF15163.1 KII60693.1 - 0.1 12.9 0.7 0.37 11.1 0.4 1.8 1 1 1 2 2 2 0 Meiosis-expressed Kunitz_BPTI PF00014.18 KII60695.1 - 0.013 15.6 11.5 0.013 15.6 7.9 2.5 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain Toxin_49 PF15529.1 KII60695.1 - 0.03 14.2 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Putative toxin 49 rve PF00665.21 KII60697.1 - 1.8e-28 99.0 0.0 3.7e-28 98.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60697.1 - 0.0012 18.3 0.0 0.0027 17.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII60697.1 - 0.0066 16.4 0.4 0.058 13.3 0.0 2.2 2 0 0 2 2 2 1 DDE domain LysM PF01476.15 KII60698.1 - 0.17 11.7 1.0 0.63 9.9 0.0 2.6 2 0 0 2 2 2 0 LysM domain rve PF00665.21 KII60700.1 - 5.4e-22 78.1 0.0 7.9e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60700.1 - 9.7e-06 25.0 0.0 2.6e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain U1snRNP70_N PF12220.3 KII60701.1 - 0.044 14.0 0.0 0.064 13.5 0.0 1.3 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal EF-hand_1 PF00036.27 KII60707.1 - 8.1e-10 37.2 2.3 4.4e-05 22.4 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KII60707.1 - 2.3e-07 30.8 0.7 5.9e-07 29.5 0.5 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KII60707.1 - 5.7e-07 28.5 0.8 0.0031 16.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KII60707.1 - 7.3e-07 28.7 4.9 0.0019 17.7 0.1 3.0 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KII60707.1 - 2.7e-06 26.8 1.6 0.13 12.2 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain SCRG1 PF15224.1 KII60707.1 - 0.12 12.2 0.3 0.23 11.2 0.2 1.5 1 0 0 1 1 1 0 Scrapie-responsive protein 1 DDE_Tnp_IS1595 PF12762.2 KII60708.1 - 2e-09 37.4 0.0 2.1e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Kinesin PF00225.18 KII60709.1 - 2.5e-44 151.3 0.0 3.5e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain HCMV_UL139 PF12507.3 KII60710.1 - 0.019 15.1 1.6 0.038 14.1 0.7 1.8 1 1 0 1 1 1 0 Human Cytomegalovirus UL139 protein Bacillus_HBL PF05791.6 KII60710.1 - 0.052 12.9 16.8 0.053 12.9 7.7 2.3 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) YfhO PF09586.5 KII60710.1 - 0.1 10.6 1.0 0.11 10.5 0.7 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Sipho_Gp157 PF05565.6 KII60710.1 - 0.16 11.5 11.5 0.043 13.3 4.8 2.0 1 1 1 2 2 2 0 Siphovirus Gp157 Reo_sigmaC PF04582.7 KII60710.1 - 0.64 9.1 6.5 0.78 8.8 3.4 1.6 1 1 1 2 2 2 0 Reovirus sigma C capsid protein eIF-4B PF06273.6 KII60710.1 - 1.5 7.5 6.2 2 7.1 4.3 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B DUF3735 PF12537.3 KII60710.1 - 2.3 8.3 4.2 37 4.4 1.6 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3735) Cep57_CLD_2 PF14197.1 KII60710.1 - 3.1 7.8 19.5 0.13 12.1 2.5 3.5 1 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF883 PF05957.8 KII60710.1 - 3.3 8.1 6.2 2.2 8.7 2.3 2.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) TBPIP PF07106.8 KII60710.1 - 3.9 6.9 21.8 1.9 8.0 7.1 2.6 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SlyX PF04102.7 KII60710.1 - 5.3 7.5 10.4 6.3 7.2 1.0 3.1 1 1 0 2 2 2 0 SlyX Laminin_II PF06009.7 KII60710.1 - 9.3 6.0 14.1 9.1 6.0 1.7 2.2 1 1 1 2 2 2 0 Laminin Domain II DUF4559 PF15112.1 KII60711.1 - 0.066 12.3 14.9 0.074 12.2 8.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) Filament PF00038.16 KII60711.1 - 0.073 12.5 15.2 0.041 13.3 3.1 2.2 1 1 1 2 2 2 0 Intermediate filament protein IncA PF04156.9 KII60711.1 - 0.53 9.8 15.0 0.47 10.0 6.1 2.1 1 1 1 2 2 2 0 IncA protein Sec20 PF03908.8 KII60711.1 - 1.8 8.3 7.8 6.5 6.5 0.3 3.0 2 1 1 3 3 3 0 Sec20 GTP_EFTU_D2 PF03144.20 KII60712.1 - 0.00021 21.3 0.1 0.0003 20.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu domain 2 IF-2 PF11987.3 KII60713.1 - 8.3e-33 112.5 1.5 1.8e-32 111.4 1.1 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 KII60713.1 - 8.3e-08 32.2 1.2 3.5e-07 30.2 0.1 2.3 1 1 1 2 2 2 2 Elongation factor Tu domain 2 SmpB PF01668.13 KII60713.1 - 0.054 13.3 0.3 0.74 9.6 0.0 2.7 3 0 0 3 3 3 0 SmpB protein IF2_N PF04760.10 KII60714.1 - 9.1e-15 54.0 0.9 1.8e-14 53.0 0.6 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region GTP_EFTU PF00009.22 KII60714.1 - 4.9e-12 45.6 1.2 4.9e-12 45.6 0.9 2.9 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KII60714.1 - 1.3e-05 25.1 0.0 3.7e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KII60714.1 - 0.00091 18.4 1.2 0.0026 16.9 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit DUF966 PF06136.8 KII60714.1 - 0.0093 15.4 9.1 0.011 15.1 6.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF966) Miro PF08477.8 KII60714.1 - 0.039 14.4 0.0 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 Miro-like protein BDV_G PF06208.6 KII60714.1 - 0.039 12.8 0.0 0.053 12.4 0.0 1.1 1 0 0 1 1 1 0 Borna disease virus G protein FeoB_N PF02421.13 KII60714.1 - 0.055 12.7 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.18 KII60714.1 - 2.5 7.9 7.0 4.4 7.1 0.0 3.1 2 1 1 3 3 3 0 Dynamin family Rrn6 PF10214.4 KII60714.1 - 2.8 5.9 5.4 3.4 5.6 3.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SAPS PF04499.10 KII60714.1 - 3.6 6.1 6.5 5.1 5.6 4.5 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pterin_bind PF00809.17 KII60715.1 - 3.7e-72 242.1 0.0 5.2e-72 241.6 0.0 1.2 1 0 0 1 1 1 1 Pterin binding enzyme TSNR_N PF04705.7 KII60715.1 - 0.044 13.5 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 Thiostrepton-resistance methylase, N terminus Peptidase_M41 PF01434.13 KII60716.1 - 2.6e-25 89.1 0.1 3.1e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M41 CSTF2_hinge PF14327.1 KII60716.1 - 0.00027 20.9 0.1 0.00041 20.3 0.1 1.3 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 WD40 PF00400.27 KII60717.1 - 7.9e-19 66.7 3.3 0.00036 20.3 0.0 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat PRP4 PF08799.6 KII60717.1 - 0.0075 15.5 1.5 0.021 14.0 1.0 1.8 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like DUF3856 PF12968.2 KII60717.1 - 0.04 13.7 0.1 0.065 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) Asp_protease_2 PF13650.1 KII60720.1 - 1.3e-05 25.6 0.0 0.00061 20.2 0.0 2.1 1 1 1 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KII60720.1 - 1.7e-05 24.5 0.0 3.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII60720.1 - 0.027 14.4 0.0 0.071 13.0 0.0 1.7 1 1 1 2 2 2 0 Retroviral aspartyl protease MRP-S25 PF13741.1 KII60720.1 - 0.041 13.3 0.1 0.067 12.6 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S25 Asp_protease PF09668.5 KII60720.1 - 0.12 11.9 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Aspartyl protease GUB_WAK_bind PF13947.1 KII60721.1 - 0.04 14.4 1.1 0.049 14.1 0.8 1.2 1 0 0 1 1 1 0 Wall-associated receptor kinase galacturonan-binding DED PF01335.16 KII60722.1 - 0.044 13.8 0.1 0.044 13.8 0.1 3.2 4 0 0 4 4 4 0 Death effector domain DUF4188 PF13826.1 KII60722.1 - 0.085 12.9 3.3 0.16 12.0 1.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4188) DUF1884 PF08967.5 KII60722.1 - 0.22 11.6 2.8 9.1 6.4 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1884) Reo_sigmaC PF04582.7 KII60722.1 - 0.24 10.5 10.5 0.69 9.0 1.8 2.2 1 1 0 2 2 2 0 Reovirus sigma C capsid protein Adeno_PIX PF03955.9 KII60722.1 - 0.44 11.0 11.9 6.7 7.2 0.2 3.7 2 1 2 4 4 4 0 Adenovirus hexon-associated protein (IX) Nup54 PF13874.1 KII60722.1 - 0.62 9.7 21.8 0.8 9.3 3.8 3.1 1 1 1 3 3 3 0 Nucleoporin complex subunit 54 Laminin_II PF06009.7 KII60722.1 - 0.77 9.5 24.9 0.15 11.8 2.2 3.9 1 1 3 4 4 4 0 Laminin Domain II TPR_MLP1_2 PF07926.7 KII60722.1 - 1.8 8.3 33.2 0.28 10.9 2.9 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein CHD5 PF04420.9 KII60722.1 - 3 7.4 9.8 3.5 7.2 0.8 3.1 2 1 1 3 3 3 0 CHD5-like protein DUF342 PF03961.8 KII60722.1 - 4.5 5.5 26.2 0.65 8.3 5.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF342) CesA PF11439.3 KII60722.1 - 4.7 7.2 9.7 1.2 9.0 0.9 3.4 2 2 0 2 2 2 0 Type III secretion system filament chaperone CesA Syntaxin_2 PF14523.1 KII60722.1 - 4.8 7.2 28.1 7.4 6.6 6.4 3.9 2 2 0 2 2 2 0 Syntaxin-like protein IncA PF04156.9 KII60722.1 - 6 6.4 27.4 8.4 5.9 8.7 3.1 1 1 1 2 2 2 0 IncA protein SAC3_GANP PF03399.11 KII60723.1 - 5.4e-47 159.9 4.1 8.6e-47 159.3 2.8 1.3 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 KII60723.1 - 5.8e-07 29.3 0.8 1.3e-06 28.2 0.6 1.5 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 ATP_bind_1 PF03029.12 KII60724.1 - 7.2e-61 205.7 0.1 8.7e-61 205.4 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_14 PF13173.1 KII60724.1 - 0.001 19.0 0.0 0.0031 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KII60724.1 - 0.0016 19.2 0.0 0.0054 17.5 0.0 1.9 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KII60724.1 - 0.0025 16.9 0.0 0.0043 16.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 KII60724.1 - 0.0045 17.1 0.0 0.009 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KII60724.1 - 0.022 14.4 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.18 KII60724.1 - 0.034 14.1 0.0 0.1 12.5 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.1 KII60724.1 - 0.048 13.5 0.0 0.064 13.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain cobW PF02492.14 KII60724.1 - 0.058 12.8 0.3 0.19 11.1 0.0 2.0 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain ADK PF00406.17 KII60724.1 - 0.062 13.1 0.0 3.1 7.6 0.0 2.4 2 1 0 2 2 2 0 Adenylate kinase AAA PF00004.24 KII60724.1 - 0.07 13.3 0.0 0.21 11.8 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 KII60724.1 - 0.081 13.2 0.1 0.3 11.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KII60724.1 - 0.085 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RepB-RCR_reg PF10723.4 KII60725.1 - 0.023 14.4 0.6 0.12 12.1 0.0 2.2 1 1 1 2 2 2 0 Replication regulatory protein RepB HTH_Tnp_IS630 PF01710.11 KII60726.1 - 0.0023 17.5 0.0 0.0043 16.7 0.0 1.4 1 0 0 1 1 1 1 Transposase CS PF04969.11 KII60728.1 - 0.034 14.6 0.2 0.092 13.3 0.1 1.7 1 0 0 1 1 1 0 CS domain RVP PF00077.15 KII60730.1 - 1.2e-05 25.1 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII60730.1 - 0.08 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4319 PF14203.1 KII60731.1 - 0.0033 16.9 2.1 0.22 11.0 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4319) NPV_P10 PF05531.7 KII60731.1 - 0.059 13.6 1.2 0.059 13.6 0.8 2.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AAA_23 PF13476.1 KII60731.1 - 0.086 13.1 4.8 0.12 12.6 3.3 1.3 1 0 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.7 KII60731.1 - 0.15 11.7 6.8 0.38 10.5 4.7 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein FliD_N PF02465.13 KII60731.1 - 0.18 12.2 0.5 0.38 11.1 0.3 1.5 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF2762 PF10960.3 KII60731.1 - 0.26 11.0 6.0 1.8 8.3 2.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2762) Nsp1_C PF05064.8 KII60731.1 - 0.26 10.9 4.6 0.13 11.9 0.9 1.9 2 0 0 2 2 2 0 Nsp1-like C-terminal region DUF1664 PF07889.7 KII60731.1 - 0.98 9.2 4.0 0.43 10.3 1.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin PF00804.20 KII60731.1 - 7.7 6.7 9.7 15 5.7 5.3 2.4 2 1 0 2 2 2 0 Syntaxin ECR1_N PF14382.1 KII60732.1 - 3.1e-10 39.1 0.1 1.7e-09 36.7 0.0 2.2 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 KII60732.1 - 8e-10 38.5 0.1 1.4e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 Ribosomal_L27 PF01016.14 KII60732.1 - 0.0027 17.4 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein ECR1_N PF14382.1 KII60734.1 - 3.1e-10 39.1 0.1 1.7e-09 36.7 0.0 2.2 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 KII60734.1 - 8e-10 38.5 0.1 1.4e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 Ribosomal_L27 PF01016.14 KII60734.1 - 0.0027 17.4 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein Med31 PF05669.7 KII60736.1 - 0.08 12.6 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 SOH1 Acetyltransf_1 PF00583.19 KII60737.1 - 5.5e-12 45.5 0.0 1.1e-11 44.5 0.0 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.5 KII60737.1 - 1.8e-06 27.5 0.0 2.9e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 KII60737.1 - 7.1e-06 26.1 0.0 1e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KII60737.1 - 1.5e-05 25.0 0.0 3.3e-05 23.9 0.0 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KII60737.1 - 0.00018 21.4 0.0 0.00027 20.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 KII60737.1 - 0.012 15.5 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MULE PF10551.4 KII60738.1 - 1.8e-06 27.9 0.3 5.1e-06 26.5 0.2 1.7 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.11 KII60738.1 - 1.5e-05 24.7 1.4 5.7e-05 22.9 1.0 2.1 1 0 0 1 1 1 1 FLYWCH zinc finger domain DDE_Tnp_IS1595 PF12762.2 KII60739.1 - 1.6e-22 79.9 0.0 7.7e-22 77.7 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain Cyt-b5 PF00173.23 KII60740.1 - 2e-19 69.1 0.0 2.4e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF771 PF05595.6 KII60740.1 - 0.013 15.4 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF771) Aldedh PF00171.17 KII60741.1 - 2.7e-85 286.4 0.0 4.5e-85 285.7 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Bac_Ubq_Cox PF01654.12 KII60743.1 - 0.0092 14.4 0.1 0.01 14.2 0.1 1.2 1 0 0 1 1 1 1 Bacterial Cytochrome Ubiquinol Oxidase Ldl_recept_a PF00057.13 KII60744.1 - 1.9e-05 24.4 16.1 1.9e-05 24.4 11.2 2.1 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A DUF832 PF05734.6 KII60745.1 - 0.23 10.6 1.9 0.32 10.1 0.9 1.5 1 1 1 2 2 2 0 Herpesvirus protein of unknown function (DUF832) SNAP PF14938.1 KII60746.1 - 0.00017 20.8 2.7 0.00022 20.5 0.4 1.9 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII60746.1 - 0.15 11.7 1.7 0.18 11.5 0.1 2.0 3 0 0 3 3 3 0 TPR repeat DDE_3 PF13358.1 KII60748.1 - 1e-10 41.5 0.1 1.3e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease 3H PF02829.9 KII60748.1 - 0.14 12.2 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 3H domain PAX PF00292.13 KII60749.1 - 1.4e-09 37.7 0.7 1.7e-09 37.4 0.1 1.5 2 0 0 2 2 2 1 'Paired box' domain HTH_32 PF13565.1 KII60749.1 - 0.015 16.1 0.6 0.14 12.9 0.1 2.1 1 1 1 2 2 2 0 Homeodomain-like domain MIG-14_Wnt-bd PF06664.7 KII60750.1 - 0.051 12.4 2.2 0.057 12.2 1.5 1.1 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion zf-C3HC4_3 PF13920.1 KII60751.1 - 6.3e-09 35.3 5.0 8.5e-09 34.9 3.5 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KII60751.1 - 1.3e-05 25.1 9.0 2e-05 24.5 6.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KII60751.1 - 0.0025 17.6 6.3 0.0039 16.9 4.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KII60751.1 - 0.0046 16.5 8.5 0.008 15.8 5.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.9 KII60751.1 - 0.0099 15.3 2.5 0.014 14.8 1.7 1.2 1 0 0 1 1 1 1 P-11 zinc finger UPF0547 PF10571.4 KII60751.1 - 0.11 12.2 0.4 0.11 12.2 0.2 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-RING_5 PF14634.1 KII60751.1 - 0.17 11.6 9.4 0.92 9.2 6.5 2.0 1 1 0 1 1 1 0 zinc-RING finger domain DZR PF12773.2 KII60751.1 - 0.29 11.0 6.8 3.8 7.3 4.7 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_3 PF14369.1 KII60751.1 - 0.58 10.2 5.9 0.54 10.2 2.2 2.3 2 1 0 2 2 2 0 zinc-finger zf-ribbon_3 PF13248.1 KII60751.1 - 5.3 6.3 11.3 1.9 7.8 0.1 3.2 2 1 0 3 3 3 0 zinc-ribbon domain DDE_Tnp_IS1595 PF12762.2 KII60752.1 - 0.00029 20.7 0.0 0.00037 20.3 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII60754.1 - 5.6e-18 65.2 0.2 6.5e-18 65.0 0.2 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain Thr_dehydrat_C PF00585.13 KII60755.1 - 0.025 14.1 0.1 0.047 13.2 0.0 1.5 1 1 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase DUF3550 PF12070.3 KII60755.1 - 0.056 12.1 0.2 0.058 12.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3550/UPF0682) Thioredoxin PF00085.15 KII60757.1 - 1.2e-06 28.0 0.5 1.9e-06 27.4 0.4 1.3 1 0 0 1 1 1 1 Thioredoxin EphA2_TM PF14575.1 KII60758.1 - 0.0004 20.7 0.1 0.0038 17.5 0.0 2.1 1 1 1 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain IncA PF04156.9 KII60758.1 - 0.0073 15.9 0.7 0.61 9.6 0.0 2.1 2 0 0 2 2 2 1 IncA protein BatD PF13584.1 KII60758.1 - 0.0085 14.7 0.3 0.0099 14.5 0.2 1.0 1 0 0 1 1 1 1 Oxygen tolerance TMEM154 PF15102.1 KII60758.1 - 0.043 13.5 0.7 0.061 13.0 0.5 1.4 1 1 0 1 1 1 0 TMEM154 protein family Rax2 PF12768.2 KII60758.1 - 0.047 12.9 0.1 0.09 11.9 0.0 1.5 1 1 1 2 2 2 0 Cortical protein marker for cell polarity DUF4446 PF14584.1 KII60758.1 - 0.14 12.0 0.7 18 5.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) SbcD_C PF12320.3 KII60758.1 - 6.2 6.9 7.7 1.2 9.1 2.1 1.8 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain adh_short PF00106.20 KII60759.1 - 2.8e-07 30.5 0.0 4.1e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KII60759.1 - 7.8e-05 22.4 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 KR domain DapB_N PF01113.15 KII60759.1 - 0.0014 18.5 0.1 0.004 17.0 0.1 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.16 KII60759.1 - 0.0034 16.8 0.0 0.0056 16.1 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 KII60759.1 - 0.03 14.6 0.0 0.05 13.9 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CPSase_sm_chain PF00988.17 KII60759.1 - 0.092 12.2 0.1 0.21 11.0 0.0 1.6 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase small chain, CPSase domain Sec1 PF00995.18 KII60760.1 - 4.8e-07 28.8 0.0 7.6e-07 28.1 0.0 1.3 1 1 0 1 1 1 1 Sec1 family DDE_3 PF13358.1 KII60762.1 - 1.5e-10 40.9 0.1 1.8e-10 40.7 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII60762.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Adap_comp_sub PF00928.16 KII60762.1 - 0.14 11.2 0.2 0.22 10.6 0.1 1.2 1 1 0 1 1 1 0 Adaptor complexes medium subunit family PDDEXK_5 PF11645.3 KII60765.1 - 0.055 13.1 0.4 0.099 12.3 0.2 1.5 1 1 0 1 1 1 0 PD-(D/E)XK endonuclease BNR PF02012.15 KII60766.1 - 1.3e-05 24.2 2.9 0.07 12.9 0.1 3.6 3 0 0 3 3 3 3 BNR/Asp-box repeat BNR_2 PF13088.1 KII60766.1 - 0.11 11.7 0.1 0.78 8.9 0.1 2.1 1 1 0 1 1 1 0 BNR repeat-like domain NosD PF05048.8 KII60767.1 - 0.013 14.7 2.7 0.018 14.2 1.9 1.2 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) rve PF00665.21 KII60769.1 - 1.5e-20 73.5 0.1 2.3e-20 72.8 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60769.1 - 0.0011 18.4 0.0 0.0025 17.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII60769.1 - 0.044 13.5 0.1 0.074 12.7 0.1 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Nepo_coat_N PF03689.10 KII60769.1 - 0.05 13.3 0.1 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain DDE_Tnp_IS1595 PF12762.2 KII60770.1 - 1.9e-15 57.0 0.0 2.1e-15 56.8 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF2042 PF09743.4 KII60774.1 - 3.4e-16 59.3 3.9 3.7e-16 59.2 2.7 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2042) DUF2682 PF10909.3 KII60774.1 - 0.13 12.6 1.6 0.64 10.3 0.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2682) DUF4513 PF14983.1 KII60774.1 - 0.13 12.1 0.3 0.71 9.7 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4513) HAD PF12710.2 KII60775.1 - 2.7e-13 50.5 0.0 6.4e-13 49.2 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII60775.1 - 4.8e-12 45.6 0.0 1.5e-11 44.0 0.0 1.9 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 KII60775.1 - 5.7e-11 43.2 0.0 2.6e-09 37.8 0.0 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KII60775.1 - 0.025 14.1 0.3 0.025 14.1 0.2 2.2 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase rve PF00665.21 KII60776.1 - 1.3e-24 86.6 0.0 2e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60776.1 - 0.0032 16.9 0.9 0.13 11.7 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Tcp11 PF05794.8 KII60776.1 - 0.049 12.3 0.1 0.073 11.7 0.1 1.2 1 0 0 1 1 1 0 T-complex protein 11 AAT PF03417.11 KII60781.1 - 0.06 12.7 0.3 0.097 12.1 0.2 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Cellsynth_D PF03500.8 KII60788.1 - 0.1 12.2 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Cellulose synthase subunit D FAM60A PF15396.1 KII60789.1 - 1.2e-07 31.6 0.1 1.2e-07 31.6 0.1 1.5 2 0 0 2 2 2 1 Protein Family FAM60A Gal-3-0_sulfotr PF06990.6 KII60790.1 - 6.8e-32 110.6 4.9 4e-31 108.0 3.4 1.8 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Borrelia_orfD PF02999.9 KII60790.1 - 1.4 9.1 6.4 0.57 10.3 0.3 2.8 3 0 0 3 3 3 0 Borrelia orf-D family SANTA PF09133.5 KII60795.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 SANTA (SANT Associated) MANEC PF07502.9 KII60796.1 - 6 6.9 34.1 1.5 8.8 6.3 4.6 3 3 0 3 3 3 0 MANEC domain rve PF00665.21 KII60797.1 - 1.9e-28 99.0 0.0 3.2e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII60797.1 - 0.00036 20.4 0.3 0.0014 18.5 0.0 1.9 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII60797.1 - 0.0035 16.8 0.0 0.011 15.1 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain DUF4522 PF15022.1 KII60797.1 - 0.077 12.7 0.1 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) DDE_3 PF13358.1 KII60798.1 - 2.8e-10 40.1 0.1 1e-09 38.3 0.0 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease Sigma_reg_N PF13800.1 KII60799.1 - 0.024 14.6 0.7 0.37 10.8 0.1 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal TFIIA_gamma_N PF02268.11 KII60803.1 - 6e-13 48.1 0.0 9.3e-13 47.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.9 KII60803.1 - 1.1e-09 37.9 0.6 1.6e-09 37.3 0.4 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit Methyltransf_10 PF05971.7 KII60804.1 - 9.5e-48 162.8 0.0 6.4e-34 117.4 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF890) Methyltransf_26 PF13659.1 KII60804.1 - 0.025 14.6 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 KII60804.1 - 0.041 14.2 0.0 0.095 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 KII60804.1 - 0.043 13.1 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DNA_pol_A PF00476.15 KII60806.1 - 2.7e-68 230.3 0.0 3.8e-68 229.8 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.15 KII60806.1 - 5.9e-06 25.8 0.0 1.5e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 3'-5' exonuclease DUF939 PF06081.6 KII60810.1 - 0.16 11.8 10.2 0.2 11.5 7.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF939) H_PPase PF03030.11 KII60810.1 - 0.27 9.4 6.2 0.32 9.1 4.3 1.0 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase Cation_ATPase_C PF00689.16 KII60810.1 - 5.6 6.4 15.6 15 5.0 10.8 1.8 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus UDPG_MGDP_dh_N PF03721.9 KII60811.1 - 5.2e-22 78.1 0.0 5.8e-22 77.9 0.0 1.0 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.18 KII60811.1 - 0.012 15.3 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_C PF03720.10 KII60812.1 - 1.5e-30 105.4 0.1 2e-30 105.0 0.1 1.1 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_synthase PF02540.12 KII60812.1 - 0.068 12.0 0.1 0.08 11.8 0.0 1.1 1 0 0 1 1 1 0 NAD synthase Rgp1 PF08737.5 KII60813.1 - 5.4e-05 22.4 0.9 0.00016 20.9 0.1 1.8 1 1 1 2 2 2 2 Rgp1 Mob1_phocein PF03637.12 KII60814.1 - 2.3e-58 196.7 0.1 2.8e-58 196.4 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family Phosducin PF02114.11 KII60814.1 - 0.043 12.5 0.0 0.12 11.1 0.0 1.6 1 1 1 2 2 2 0 Phosducin Sec23_helical PF04815.10 KII60814.1 - 0.053 12.9 0.1 1.2 8.5 0.0 2.3 3 0 0 3 3 3 0 Sec23/Sec24 helical domain DDE_1 PF03184.14 KII60816.1 - 2.2e-16 59.6 0.5 2.3e-10 40.0 0.0 3.1 2 2 1 3 3 3 3 DDE superfamily endonuclease ABC_tran PF00005.22 KII60821.1 - 0.0024 18.1 0.0 0.0034 17.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KII60821.1 - 0.0035 17.3 0.1 0.0063 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 KII60821.1 - 0.048 12.8 0.0 0.067 12.4 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DDE_3 PF13358.1 KII60823.1 - 1.2e-05 25.0 0.0 3.5e-05 23.5 0.0 1.6 1 1 1 2 2 2 2 DDE superfamily endonuclease Radical_SAM PF04055.16 KII60824.1 - 1.5e-17 64.2 0.1 2.3e-17 63.6 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.15 KII60824.1 - 2.9e-08 33.3 0.4 1.4e-07 31.2 0.0 2.1 2 0 0 2 2 2 1 TRAM domain CMD PF02627.15 KII60824.1 - 0.12 12.1 0.1 0.43 10.4 0.0 1.8 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family Ten1 PF12658.2 KII60826.1 - 0.098 12.4 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Telomere capping, CST complex subunit DDE_3 PF13358.1 KII60828.1 - 1.1e-28 99.8 0.0 1.8e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HNH_2 PF13391.1 KII60828.1 - 0.026 14.3 0.0 0.57 10.0 0.0 2.5 2 0 0 2 2 2 0 HNH endonuclease rve PF00665.21 KII60828.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain HTH_6 PF01418.12 KII60829.1 - 0.026 14.2 0.1 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family RVT_1 PF00078.22 KII60829.1 - 0.11 11.8 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII60830.1 - 7.9e-08 32.4 0.0 1e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain SNAP PF14938.1 KII60833.1 - 1.3e-15 57.3 3.3 2.2e-15 56.5 2.3 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII60833.1 - 0.0088 15.9 4.8 0.057 13.3 0.6 3.5 1 1 2 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII60833.1 - 0.014 15.2 8.4 0.33 10.9 0.4 4.6 4 1 0 5 5 5 0 Tetratricopeptide repeat DUF2312 PF10073.4 KII60833.1 - 0.028 13.7 0.1 0.053 12.8 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) TPR_14 PF13428.1 KII60833.1 - 0.17 12.6 0.6 27 5.7 0.1 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII60833.1 - 0.2 11.3 7.7 0.65 9.6 1.9 3.6 3 1 1 4 4 4 0 TPR repeat TPR_8 PF13181.1 KII60833.1 - 0.35 10.7 7.6 0.55 10.1 0.5 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat NSF PF02071.15 KII60833.1 - 0.75 10.5 7.8 1.1e+02 4.1 0.1 5.5 5 1 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat Glyco_hydro_38C PF07748.8 KII60837.1 - 1.4e-31 109.8 0.1 1.8e-31 109.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro_38 PF01074.17 KII60837.1 - 7.4e-29 100.8 0.0 1.2e-28 100.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.6 KII60837.1 - 0.015 15.4 0.2 0.045 13.9 0.1 1.8 1 0 0 1 1 1 0 Alpha mannosidase, middle domain Amidase PF01425.16 KII60839.1 - 7.4e-09 34.9 0.0 1.1e-08 34.3 0.0 1.3 1 1 0 1 1 1 1 Amidase RVP PF00077.15 KII60841.1 - 2.2e-09 37.1 0.1 4.5e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII60841.1 - 4.2e-05 23.2 8.3 0.0023 17.8 0.2 2.5 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII60841.1 - 0.0011 19.4 0.0 0.0027 18.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease UBN2 PF14223.1 KII60841.1 - 0.011 15.5 0.2 0.044 13.5 0.0 2.1 2 1 0 2 2 2 0 gag-polypeptide of LTR copia-type Peptidase_A2E PF12382.3 KII60841.1 - 0.012 15.3 0.2 0.031 14.0 0.1 1.7 1 1 0 1 1 1 0 Retrotransposon peptidase gag-asp_proteas PF13975.1 KII60841.1 - 0.023 14.4 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII60841.1 - 0.14 11.8 6.9 0.22 11.2 1.0 2.8 2 0 0 2 2 2 0 Zinc knuckle Copper-fist PF00649.13 KII60841.1 - 0.18 11.0 7.1 0.087 12.0 3.1 1.8 1 1 1 2 2 2 0 Copper fist DNA binding domain ZZ PF00569.12 KII60841.1 - 0.57 9.7 4.7 1.5 8.4 3.3 1.7 1 0 0 1 1 1 0 Zinc finger, ZZ type C1_1 PF00130.17 KII60842.1 - 0.0086 15.7 1.5 0.016 14.9 1.1 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Tospo_nucleocap PF01533.11 KII60842.1 - 0.12 11.5 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Tospovirus nucleocapsid protein FYVE PF01363.16 KII60842.1 - 0.39 10.6 5.3 0.51 10.2 3.7 1.4 1 1 0 1 1 1 0 FYVE zinc finger zf-UBR PF02207.15 KII60843.1 - 2.6e-12 46.2 7.5 2.6e-12 46.2 5.2 3.2 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) Phostensin PF13914.1 KII60845.1 - 0.14 12.3 0.1 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Phostensin PP1-binding and SH3-binding region DUF4537 PF15057.1 KII60846.1 - 8e-10 38.5 0.6 3.5e-05 23.5 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4537) DDE_Tnp_IS1595 PF12762.2 KII60848.1 - 1.1e-16 61.0 0.6 1.6e-14 53.9 0.2 2.2 1 1 1 2 2 2 2 ISXO2-like transposase domain DUF3797 PF12677.2 KII60848.1 - 0.22 11.1 3.4 1.5 8.4 0.8 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF3797) Cpn60_TCP1 PF00118.19 KII60849.1 - 3.1e-134 448.2 14.0 3.6e-134 448.0 9.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HAD PF12710.2 KII60849.1 - 0.15 12.1 0.3 4 7.5 0.2 2.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase rve PF00665.21 KII60850.1 - 1.6e-25 89.5 0.0 5.4e-25 87.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII60850.1 - 1.9e-06 27.3 0.1 4.7e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-RING_2 PF13639.1 KII60853.1 - 1.8e-10 40.4 5.9 3.2e-10 39.6 4.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KII60853.1 - 5.9e-08 32.6 3.6 1.4e-07 31.4 2.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 KII60853.1 - 3.3e-07 29.9 6.3 5.3e-07 29.2 4.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KII60853.1 - 3e-06 26.7 3.8 5.4e-06 25.9 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KII60853.1 - 2.3e-05 24.3 7.8 4.2e-05 23.4 5.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII60853.1 - 0.00013 21.5 6.9 0.00025 20.6 4.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KII60853.1 - 0.00061 19.5 5.4 0.0071 16.1 3.7 2.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 KII60853.1 - 0.2 11.2 2.5 0.38 10.3 1.7 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.2 KII60853.1 - 0.47 10.5 4.5 1.4 9.0 3.1 1.8 1 1 0 1 1 1 0 RING-variant domain PHD PF00628.24 KII60853.1 - 0.61 9.8 5.9 2.3 7.9 4.2 1.9 1 1 1 2 2 2 0 PHD-finger Prok-RING_1 PF14446.1 KII60853.1 - 1.5 8.5 4.3 6.5 6.5 3.0 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 FANCL_C PF11793.3 KII60853.1 - 1.6 8.7 6.4 7.2 6.6 4.4 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 KII60853.1 - 2.4 8.0 7.5 30 4.5 5.6 2.5 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DUF3951 PF13131.1 KII60853.1 - 2.6 7.9 8.1 8.5 6.2 5.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) zf-RING_UBOX PF13445.1 KII60853.1 - 4.8 6.9 6.1 15 5.4 1.1 2.4 2 0 0 2 2 2 0 RING-type zinc-finger DDE_3 PF13358.1 KII60854.1 - 9.4e-15 54.6 0.1 1.2e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_transf_10 PF00852.14 KII60857.1 - 8.6e-48 162.6 6.3 1e-47 162.4 4.3 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) Glyco_transf_10 PF00852.14 KII60858.1 - 2.6e-47 161.0 3.8 3e-47 160.9 2.6 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) DUF4450 PF14614.1 KII60858.1 - 0.13 11.3 1.0 1.1 8.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4450) Glyco_transf_10 PF00852.14 KII60859.1 - 1.2e-46 158.9 7.2 1.4e-46 158.7 5.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) RSF PF14876.1 KII60859.1 - 0.06 12.1 0.3 0.089 11.5 0.2 1.2 1 0 0 1 1 1 0 Respiratory growth transcriptional regulator DDE_3 PF13358.1 KII60860.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease Peptidase_C48 PF02902.14 KII60862.1 - 0.09 12.3 0.9 2.1 7.9 0.2 2.0 2 0 0 2 2 2 0 Ulp1 protease family, C-terminal catalytic domain DUF3514 PF12027.3 KII60863.1 - 0.08 12.1 0.2 0.082 12.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3514) Desulfoferrod_N PF06397.7 KII60863.1 - 0.081 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain IlvGEDA_leader PF08046.6 KII60864.1 - 0.78 8.9 3.7 1.4 8.1 2.5 1.4 1 0 0 1 1 1 0 IlvGEDA operon leader peptide GP4 PF03010.9 KII60865.1 - 0.066 12.8 0.1 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 GP4 Lipocalin_4 PF13648.1 KII60865.1 - 5.1 7.7 6.6 36 5.0 0.1 2.8 1 1 2 3 3 3 0 Lipocalin-like domain DUF3357 PF11837.3 KII60866.1 - 0.0071 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3357) DUF4500 PF14937.1 KII60866.1 - 0.17 11.7 1.0 0.4 10.5 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4500) Sigma_reg_N PF13800.1 KII60866.1 - 4.1 7.4 8.1 0.77 9.8 1.1 2.7 3 1 1 4 4 4 0 Sigma factor regulator N-terminal DUF4500 PF14937.1 KII60867.1 - 0.024 14.4 0.5 0.058 13.2 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4500) DUF4097 PF13349.1 KII60868.1 - 0.079 12.5 0.7 0.079 12.5 0.5 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4097) DUF3844 PF12955.2 KII60868.1 - 0.2 11.7 1.5 0.43 10.6 1.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3844) Ninjurin PF04923.7 KII60868.1 - 0.31 10.8 2.5 2.6 7.8 0.0 2.2 1 1 1 2 2 2 0 Ninjurin LysE PF01810.13 KII60869.1 - 0.062 12.5 0.1 0.085 12.1 0.1 1.2 1 0 0 1 1 1 0 LysE type translocator DUF1514 PF07438.6 KII60871.1 - 0.027 14.3 0.1 0.075 12.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1514) SNAP PF14938.1 KII60872.1 - 7.1e-15 54.9 0.9 1e-14 54.3 0.6 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII60872.1 - 0.0048 16.8 2.4 0.19 11.6 0.1 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat PPR PF01535.15 KII60872.1 - 0.17 11.9 3.1 18 5.5 0.0 3.5 3 0 0 3 3 3 0 PPR repeat SHS2_Rpb7-N PF03876.12 KII60873.1 - 0.017 15.2 0.0 0.038 14.1 0.0 1.6 1 0 0 1 1 1 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Asp_protease PF09668.5 KII60875.1 - 0.034 13.7 0.1 0.066 12.7 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease Asp_protease_2 PF13650.1 KII60875.1 - 0.13 12.7 0.3 0.57 10.7 0.1 2.1 2 0 0 2 2 2 0 Aspartyl protease zf-CCHC PF00098.18 KII60876.1 - 0.018 14.9 2.1 0.018 14.9 1.4 2.3 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.21 KII60877.1 - 1.7e-14 53.9 0.1 2.3e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII60877.1 - 0.0025 17.3 0.0 0.0046 16.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Vasohibin PF14822.1 KII60878.1 - 0.021 13.9 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Vasohibin HTH_Crp_2 PF13545.1 KII60883.1 - 0.095 12.4 0.0 0.14 11.9 0.0 1.5 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain DUF2481 PF10654.4 KII60883.1 - 0.23 11.1 3.5 1.7 8.3 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2481) adh_short PF00106.20 KII60885.1 - 2.2e-29 102.5 0.0 3.3e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KII60885.1 - 6.4e-22 78.4 0.0 8e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KII60885.1 - 4.1e-11 42.8 0.0 7e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 KII60885.1 - 0.0016 17.9 0.2 0.014 14.8 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PALP PF00291.20 KII60885.1 - 0.091 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Eno-Rase_NADH_b PF12242.3 KII60885.1 - 0.11 12.3 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase MFS_1 PF07690.11 KII60886.1 - 5.2e-26 91.1 35.9 5.2e-26 91.1 24.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KII60886.1 - 3.8e-08 32.1 35.0 5.5e-05 21.7 6.9 3.3 1 1 2 3 3 3 3 MFS/sugar transport protein Nuc_H_symport PF03825.11 KII60886.1 - 1.6e-06 27.1 23.1 2.7e-06 26.4 16.0 1.2 1 0 0 1 1 1 1 Nucleoside H+ symporter LacY_symp PF01306.14 KII60886.1 - 0.00077 18.1 14.8 0.00077 18.1 10.3 1.8 2 1 0 2 2 2 1 LacY proton/sugar symporter SNAP PF14938.1 KII60887.1 - 5.2e-07 29.0 0.4 6.2e-07 28.8 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Endotoxin_C PF03944.9 KII60888.1 - 0.0013 18.8 0.6 0.0018 18.3 0.4 1.3 1 0 0 1 1 1 1 delta endotoxin RhoGEF PF00621.15 KII60890.1 - 1.1e-32 113.3 1.9 1.8e-32 112.6 1.3 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.24 KII60890.1 - 0.0012 18.9 0.9 0.0049 17.0 0.4 2.4 2 1 0 2 2 2 1 PH domain FlhC PF05280.6 KII60892.1 - 0.084 12.3 0.1 0.25 10.8 0.0 1.8 1 1 0 1 1 1 0 Flagellar transcriptional activator (FlhC) DUF1759 PF03564.10 KII60895.1 - 5e-06 26.3 0.0 6.7e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) PNMA PF14893.1 KII60895.1 - 0.048 12.6 0.1 0.069 12.1 0.1 1.2 1 0 0 1 1 1 0 PNMA Sod_Cu PF00080.15 KII60896.1 - 5.5e-18 65.4 0.9 7.1e-18 65.1 0.6 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Peptidase_M13_N PF05649.8 KII60898.1 - 5.9e-58 196.7 2.2 1.2e-30 106.9 0.0 2.5 2 1 1 3 3 3 2 Peptidase family M13 Peptidase_M13 PF01431.16 KII60898.1 - 5e-49 166.2 0.0 8e-49 165.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 BHD_3 PF10405.4 KII60899.1 - 1.9e-25 88.3 0.1 6.8e-25 86.5 0.0 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.4 KII60899.1 - 0.00012 22.2 0.2 0.00048 20.3 0.0 2.0 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 GCK PF07802.6 KII60900.1 - 0.0051 16.9 0.7 0.0051 16.9 0.5 1.5 2 0 0 2 2 2 1 GCK domain EF-hand_10 PF14788.1 KII60900.1 - 0.051 13.2 1.5 1.4 8.6 0.1 2.3 2 0 0 2 2 2 0 EF hand FLYWCH PF04500.11 KII60902.1 - 0.011 15.5 4.8 0.017 15.0 3.3 1.3 1 0 0 1 1 1 0 FLYWCH zinc finger domain Paramyxo_P PF01806.12 KII60902.1 - 0.02 14.1 0.5 0.023 13.9 0.4 1.1 1 0 0 1 1 1 0 Paramyxovirinae P phosphoprotein C-terminal region YdjO PF14169.1 KII60902.1 - 0.029 13.8 0.1 0.048 13.1 0.1 1.4 1 0 0 1 1 1 0 Cold-inducible protein YdjO DHC PF09626.5 KII60902.1 - 0.1 13.2 0.4 0.14 12.8 0.3 1.3 1 0 0 1 1 1 0 Dihaem cytochrome c TPR_11 PF13414.1 KII60904.1 - 1.4e-10 40.6 3.1 6.3e-08 32.1 0.2 2.5 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KII60904.1 - 1.7e-09 36.8 3.5 0.0069 16.2 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 KII60904.1 - 1.7e-09 37.8 0.9 3.6e-05 24.0 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII60904.1 - 2e-07 30.8 0.6 0.00062 19.6 0.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat FKBP_C PF00254.23 KII60904.1 - 3.1e-05 23.9 0.0 8.3e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.23 KII60904.1 - 3.2e-05 23.3 6.5 0.43 10.2 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII60904.1 - 0.00044 19.8 0.7 5 7.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 KII60904.1 - 0.0012 18.9 0.4 0.0033 17.5 0.3 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 KII60904.1 - 0.0014 19.2 0.1 0.89 10.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KII60904.1 - 0.0018 18.7 0.0 3.2 8.6 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 KII60904.1 - 0.006 16.9 0.6 1 9.9 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII60904.1 - 0.083 12.7 0.3 3.2 7.7 0.0 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Prenyltrans PF00432.16 KII60905.1 - 1.2e-26 91.9 5.0 2.1e-13 49.5 0.0 5.3 6 1 0 6 6 6 2 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 KII60905.1 - 2.3e-18 66.6 0.0 1.4e-10 41.6 0.0 3.1 1 1 1 3 3 3 2 Prenyltransferase-like Prenyltrans_1 PF13243.1 KII60905.1 - 0.0023 17.9 0.0 0.44 10.5 0.0 3.1 3 1 0 3 3 3 1 Prenyltransferase-like Aconitase_C PF00694.14 KII60906.1 - 1e-44 151.8 0.0 1.6e-44 151.1 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase PF00330.15 KII60906.1 - 1.4e-40 139.1 0.0 1.7e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Pax7 PF12360.3 KII60906.1 - 0.019 15.2 0.5 0.056 13.7 0.0 2.1 2 0 0 2 2 2 0 Paired box protein 7 Kelch_6 PF13964.1 KII60908.1 - 8.3e-13 47.9 3.0 0.00039 20.4 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII60908.1 - 5.5e-07 29.5 0.4 0.00054 20.0 0.0 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII60908.1 - 8.5e-06 25.3 1.6 0.78 9.6 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 KII60908.1 - 5.5e-05 22.6 7.3 0.044 13.3 1.3 3.8 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 KII60908.1 - 0.0013 18.6 0.9 0.0055 16.6 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Ras PF00071.17 KII60909.1 - 5.8e-47 159.0 0.0 7.3e-47 158.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII60909.1 - 1.9e-14 54.1 0.0 3.2e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII60909.1 - 1e-07 31.3 0.0 1.7e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KII60909.1 - 0.049 12.7 0.0 0.066 12.3 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Transglut_C PF00927.17 KII60911.1 - 0.011 15.7 1.9 1.8 8.6 0.1 3.0 2 1 1 3 3 3 0 Transglutaminase family, C-terminal ig like domain polyprenyl_synt PF00348.12 KII60912.1 - 2.3e-44 151.2 0.1 3.6e-44 150.5 0.1 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase DDE_1 PF03184.14 KII60913.1 - 3.3e-10 39.4 0.0 5.7e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_3 PF01381.17 KII60913.1 - 0.00041 20.1 0.2 0.001 18.8 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix CENP-B_N PF04218.8 KII60913.1 - 0.00078 18.8 0.1 0.0017 17.7 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain LacI PF00356.16 KII60913.1 - 0.00088 18.8 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_38 PF13936.1 KII60913.1 - 0.0015 18.0 0.4 0.005 16.3 0.1 2.1 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_23 PF13384.1 KII60913.1 - 0.0052 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_IclR PF09339.5 KII60913.1 - 0.0068 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_psq PF05225.11 KII60913.1 - 0.0071 15.8 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_28 PF13518.1 KII60913.1 - 0.038 14.0 0.1 0.11 12.5 0.1 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.1 KII60913.1 - 0.046 13.1 0.2 0.09 12.1 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_36 PF13730.1 KII60913.1 - 0.059 13.5 0.1 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.7 KII60913.1 - 0.073 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain HTH_Tnp_Tc3_2 PF01498.13 KII60913.1 - 0.13 12.3 0.3 0.25 11.4 0.2 1.4 1 0 0 1 1 1 0 Transposase polyprenyl_synt PF00348.12 KII60914.1 - 1.9e-43 148.1 0.1 3.1e-43 147.5 0.1 1.4 1 0 0 1 1 1 1 Polyprenyl synthetase Homeobox PF00046.24 KII60917.1 - 4.7e-19 67.7 4.0 7.2e-19 67.1 2.2 1.8 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 KII60917.1 - 0.0001 21.9 1.1 0.00047 19.7 0.1 2.4 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.3 KII60917.1 - 0.014 14.4 0.6 0.026 13.5 0.1 1.7 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Ribosomal_L6e PF01159.14 KII60918.1 - 2.4e-32 111.3 0.7 2.4e-32 111.3 0.5 2.0 2 0 0 2 2 2 1 Ribosomal protein L6e Borrelia_orfA PF02414.10 KII60918.1 - 2.3 7.2 11.6 0.59 9.1 1.4 2.0 2 0 0 2 2 2 0 Borrelia ORF-A HTH_Tnp_ISL3 PF13542.1 KII60919.1 - 0.06 12.5 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 CAP PF00188.21 KII60921.1 - 0.00013 22.4 1.4 0.00015 22.2 0.4 1.5 2 0 0 2 2 2 1 Cysteine-rich secretory protein family CAP PF00188.21 KII60922.1 - 5.9e-11 42.9 0.1 7.6e-11 42.5 0.1 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family HTH_Tnp_Tc5 PF03221.11 KII60925.1 - 0.00056 19.6 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HEM4 PF02602.10 KII60928.1 - 5.3e-17 61.8 0.0 5.9e-17 61.6 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD PUF PF00806.14 KII60929.1 - 1.7e-13 49.2 0.9 4.2e-05 22.7 0.0 6.4 7 0 0 7 7 7 2 Pumilio-family RNA binding repeat RFC1 PF08519.7 KII60929.1 - 0.0062 16.3 1.0 0.028 14.1 0.3 2.3 1 1 0 2 2 2 1 Replication factor RFC1 C terminal domain PWI PF01480.12 KII60929.1 - 0.056 13.5 0.7 0.24 11.5 0.0 2.5 3 0 0 3 3 3 0 PWI domain DUF3918 PF13056.1 KII60931.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) GATA PF00320.22 KII60932.1 - 3.1e-11 42.4 5.8 8.1e-11 41.0 4.0 1.8 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.13 KII60932.1 - 0.026 14.2 1.5 0.04 13.7 0.6 1.6 1 1 0 1 1 1 0 Putative GTPase activating protein for Arf Hexokinase_2 PF03727.11 KII60933.1 - 6.5e-66 222.0 0.2 8.1e-66 221.6 0.1 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII60933.1 - 4.2e-49 166.6 0.0 6e-49 166.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF1186 PF06685.6 KII60933.1 - 0.075 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) Ldl_recept_a PF00057.13 KII60934.1 - 5.2e-07 29.4 9.7 5.2e-07 29.4 6.7 4.0 5 0 0 5 5 5 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII60934.1 - 1.4 9.0 5.0 7.6 6.8 0.1 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat zf-CCHC PF00098.18 KII60935.1 - 4.8e-05 23.0 2.0 4.8e-05 23.0 1.4 2.0 2 0 0 2 2 2 1 Zinc knuckle Viral_NABP PF05515.6 KII60935.1 - 0.013 15.7 0.2 0.055 13.7 0.1 2.0 2 0 0 2 2 2 0 Viral nucleic acid binding gag-asp_proteas PF13975.1 KII60935.1 - 0.035 13.9 0.0 0.069 12.9 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII60935.1 - 0.046 14.2 0.0 0.14 12.6 0.0 1.9 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.1 KII60935.1 - 0.26 10.9 4.9 0.079 12.6 1.0 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.1 KII60935.1 - 0.4 10.2 2.3 0.82 9.2 1.6 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger MFS_1 PF07690.11 KII60941.1 - 2e-26 92.5 21.2 4.8e-26 91.3 11.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KII60941.1 - 1.7e-08 33.5 19.8 1e-05 24.3 10.4 2.5 1 1 1 2 2 2 2 Sugar (and other) transporter OATP PF03137.15 KII60941.1 - 0.56 8.1 10.6 0.42 8.6 2.8 2.3 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII60942.1 - 5.9e-29 100.8 17.7 8.6e-29 100.3 12.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KII60942.1 - 9e-13 47.5 12.6 9e-13 47.5 8.7 2.2 2 1 0 2 2 2 1 Sugar (and other) transporter DUF1240 PF06836.7 KII60942.1 - 0.047 13.9 0.2 0.047 13.9 0.1 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF1240) Thioredoxin_3 PF13192.1 KII60944.1 - 0.016 15.0 0.1 0.023 14.4 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin domain WD40 PF00400.27 KII60945.1 - 6.6e-31 105.0 11.6 3.7e-07 29.7 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Sof1 PF04158.9 KII60945.1 - 2.6e-20 72.2 4.8 5.4e-20 71.2 3.3 1.5 1 0 0 1 1 1 1 Sof1-like domain eIF2A PF08662.6 KII60945.1 - 4.7e-06 26.4 0.3 0.08 12.6 0.0 3.2 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PRONE PF03759.8 KII60946.1 - 0.0024 16.4 1.2 0.0033 16.0 0.8 1.2 1 0 0 1 1 1 1 PRONE (Plant-specific Rop nucleotide exchanger) Phage_30_3 PF08010.6 KII60947.1 - 0.028 13.9 0.0 0.03 13.8 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 RepB PF07506.6 KII60947.1 - 0.077 12.8 0.1 0.09 12.6 0.1 1.4 1 0 0 1 1 1 0 RepB plasmid partitioning protein DUF1319 PF07028.6 KII60947.1 - 0.2 11.8 2.1 0.24 11.5 0.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Aldo_ket_red PF00248.16 KII60949.1 - 2.9e-14 52.5 0.0 3.5e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Arf PF00025.16 KII60951.1 - 1.7e-24 86.0 0.1 1.9e-24 85.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 KII60951.1 - 6.4e-06 26.6 0.2 1.1e-05 25.8 0.1 1.4 1 1 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 KII60951.1 - 8.8e-05 21.7 0.3 0.00016 20.9 0.2 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.1 KII60951.1 - 0.0007 19.4 0.1 0.0011 18.8 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII60951.1 - 0.00094 19.4 0.0 0.0013 19.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII60951.1 - 0.0022 18.8 0.0 0.0036 18.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.7 KII60951.1 - 0.0025 16.9 0.8 0.0073 15.4 0.6 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KII60951.1 - 0.0054 16.6 0.3 0.11 12.4 0.2 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 KII60951.1 - 0.012 15.7 1.0 0.047 13.8 0.7 1.8 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.13 KII60951.1 - 0.058 12.6 0.1 7.2 5.8 0.1 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.4 KII60951.1 - 0.061 12.8 0.7 0.41 10.1 0.4 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Phage-scaffold PF09306.5 KII60951.1 - 0.091 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein GTP_EFTU PF00009.22 KII60951.1 - 0.1 11.9 0.5 8.4 5.7 0.0 2.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.12 KII60951.1 - 0.12 11.9 0.0 0.36 10.3 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.1 KII60951.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.1 KII60951.1 - 0.12 11.3 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.10 KII60951.1 - 0.15 11.7 0.1 0.43 10.2 0.0 1.7 2 0 0 2 2 2 0 NTPase GNAT_acetyltran PF12746.2 KII60955.1 - 0.088 11.6 0.0 0.09 11.5 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase DUF3267 PF11667.3 KII60956.1 - 0.096 12.8 1.4 0.13 12.4 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3267) ABC_tran PF00005.22 KII60957.1 - 9.1e-11 42.2 0.0 1.4e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KII60957.1 - 2.9e-05 24.2 5.3 0.03 14.2 0.1 2.1 1 1 1 2 2 2 2 AAA domain AAA_15 PF13175.1 KII60957.1 - 0.0047 16.0 3.3 0.23 10.4 0.1 2.1 1 1 1 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 KII60957.1 - 0.1 12.1 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.1 KII60957.1 - 0.11 12.3 0.2 2.9 7.8 0.0 2.2 1 1 1 2 2 2 0 AAA domain Dus PF01207.12 KII60958.1 - 2.9e-69 233.2 0.0 3.5e-69 233.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 KII60958.1 - 0.00071 18.6 0.0 0.022 13.6 0.0 2.0 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.16 KII60958.1 - 0.002 17.4 0.0 0.0026 17.0 0.0 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF2188 PF09954.4 KII60958.1 - 0.017 15.0 0.0 0.27 11.1 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2188) ThiG PF05690.9 KII60958.1 - 0.044 12.8 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG SOR_SNZ PF01680.12 KII60958.1 - 0.049 13.2 0.0 3.3 7.2 0.0 2.1 1 1 1 2 2 2 0 SOR/SNZ family RRM_1 PF00076.17 KII60959.1 - 1.1e-12 47.3 0.0 1.6e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII60959.1 - 4.7e-10 39.3 0.0 7.3e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII60959.1 - 1.5e-06 27.9 0.1 2.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ECR1_N PF14382.1 KII60960.1 - 3.9e-08 32.4 0.0 6.4e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region GRASP55_65 PF04495.9 KII60961.1 - 6.4e-54 181.6 0.6 2.5e-41 140.8 0.1 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.1 KII60961.1 - 0.00028 20.7 0.0 0.043 13.7 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PBP PF01161.15 KII60964.1 - 7.4e-13 48.5 0.0 8.8e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein EF-hand_7 PF13499.1 KII60965.1 - 6.5e-21 74.2 6.2 9.3e-14 51.3 0.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KII60965.1 - 3.7e-19 66.5 2.5 4e-06 25.7 0.0 3.9 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 KII60965.1 - 1.2e-16 58.9 1.8 5.1e-06 25.9 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.1 KII60965.1 - 1.2e-10 40.1 1.9 7.6e-05 21.8 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KII60965.1 - 2.9e-09 36.4 5.1 1e-06 28.2 0.0 3.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.1 KII60965.1 - 2.1e-07 30.7 0.1 3.7e-05 23.5 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KII60965.1 - 0.00089 19.2 0.1 0.0069 16.4 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KII60965.1 - 0.07 12.8 0.6 0.88 9.2 0.0 3.0 3 1 1 4 4 4 0 EF hand DUF1707 PF08044.6 KII60965.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) Transglut_core PF01841.14 KII60968.1 - 1.8e-15 57.1 0.3 3.4e-15 56.2 0.2 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_N PF00868.15 KII60968.1 - 1.4e-12 47.6 0.0 3.6e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.17 KII60968.1 - 0.0001 22.2 0.1 0.00027 20.9 0.1 1.6 1 0 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain Peptidase_S24 PF00717.18 KII60969.1 - 3.9e-06 26.4 0.0 6.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like TRAPP PF04051.11 KII60970.1 - 5.8e-19 68.1 0.1 6.2e-19 68.0 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Cpn60_TCP1 PF00118.19 KII60971.1 - 1e-134 449.8 6.9 1.2e-134 449.6 4.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_S17e PF00833.13 KII60972.1 - 7.4e-52 174.2 0.1 8.4e-52 174.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal S17 BAH PF01426.13 KII60975.1 - 1.8e-08 34.1 0.1 0.0039 16.9 0.0 2.4 1 1 0 2 2 2 2 BAH domain Pkinase PF00069.20 KII60976.1 - 3e-36 124.8 0.2 5.6e-36 124.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII60976.1 - 5.6e-32 110.8 0.2 3.9e-30 104.7 0.1 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KII60976.1 - 0.0015 18.3 0.1 0.0056 16.4 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KII60976.1 - 0.14 11.1 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MTS_N PF08468.6 KII60979.1 - 0.0026 17.5 0.1 0.29 10.9 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase small domain N-terminal DUF870 PF05912.6 KII60979.1 - 0.051 13.3 0.0 0.091 12.5 0.0 1.5 1 0 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF870) FLYWCH PF04500.11 KII60980.1 - 1.2e-08 34.7 1.0 1.2e-08 34.7 0.7 1.7 2 0 0 2 2 2 1 FLYWCH zinc finger domain Oxysterol_BP PF01237.13 KII60984.1 - 4.6e-55 186.5 0.4 6e-55 186.1 0.3 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein Y_phosphatase PF00102.22 KII60985.1 - 1.3e-61 208.0 1.7 1.3e-61 208.0 1.1 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.15 KII60985.1 - 0.011 15.2 1.5 0.035 13.7 0.4 2.3 2 1 1 3 3 3 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 KII60985.1 - 0.021 15.0 0.0 0.34 11.1 0.0 2.3 2 0 0 2 2 2 0 Tyrosine phosphatase family Topoisom_bac PF01131.15 KII60986.1 - 2.2e-76 257.3 0.0 6.2e-76 255.8 0.0 1.7 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 KII60986.1 - 4.6e-14 52.1 0.0 9.8e-14 51.1 0.0 1.6 1 0 0 1 1 1 1 Toprim domain Enolase_C PF00113.17 KII60987.1 - 1.3e-151 503.6 0.3 1.6e-151 503.3 0.2 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 KII60987.1 - 2.1e-57 192.7 0.2 3.7e-57 191.9 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.1 KII60987.1 - 1e-05 25.4 0.0 2.2e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.6 KII60987.1 - 0.0035 16.3 0.3 0.0035 16.3 0.2 1.7 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus Radical_SAM PF04055.16 KII60988.1 - 7.4e-15 55.5 0.1 2.1e-14 54.0 0.1 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 KII60988.1 - 5.1e-11 42.4 0.1 1.4e-10 41.0 0.1 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Radical_SAM PF04055.16 KII60989.1 - 2.9e-15 56.8 0.1 1e-14 55.0 0.0 2.0 2 1 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 KII60989.1 - 5.8e-10 39.0 0.0 1.5e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family AAA PF00004.24 KII60990.1 - 5e-40 136.7 0.0 8.7e-40 135.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 KII60990.1 - 3.7e-20 71.5 0.0 1.1e-19 70.0 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 KII60990.1 - 1.8e-14 53.3 0.7 1.8e-14 53.3 0.5 2.0 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_17 PF13207.1 KII60990.1 - 1.1e-06 29.4 0.0 4.1e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KII60990.1 - 1.2e-05 25.1 0.0 4.9e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 KII60990.1 - 1.5e-05 24.2 0.0 0.00013 21.1 0.0 2.4 3 1 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KII60990.1 - 1.7e-05 24.9 0.0 0.0012 19.0 0.0 2.7 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.8 KII60990.1 - 2.7e-05 23.2 0.0 0.00012 21.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_25 PF13481.1 KII60990.1 - 3e-05 23.5 0.3 0.16 11.3 0.0 2.3 1 1 1 2 2 2 2 AAA domain IstB_IS21 PF01695.12 KII60990.1 - 3.1e-05 23.4 0.0 5.4e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.9 KII60990.1 - 7.8e-05 22.4 0.0 0.00023 20.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 KII60990.1 - 0.00023 19.9 0.0 0.00036 19.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_2 PF07724.9 KII60990.1 - 0.00037 20.4 0.0 0.001 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KII60990.1 - 0.00051 20.0 0.2 0.019 14.9 0.0 2.7 1 1 2 3 3 3 1 AAA ATPase domain AAA_33 PF13671.1 KII60990.1 - 0.0006 19.7 0.0 0.0014 18.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII60990.1 - 0.0031 17.8 0.1 0.0098 16.1 0.0 1.9 2 0 0 2 2 1 1 AAA domain NACHT PF05729.7 KII60990.1 - 0.013 15.1 0.0 2 8.0 0.0 2.4 1 1 1 2 2 2 0 NACHT domain Mg_chelatase PF01078.16 KII60990.1 - 0.025 13.7 0.0 0.062 12.4 0.0 1.7 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 KII60990.1 - 0.025 14.0 0.0 0.22 10.9 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.11 KII60990.1 - 0.033 13.4 0.2 0.087 12.0 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.17 KII60990.1 - 0.034 14.3 0.0 0.098 12.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.1 KII60990.1 - 0.036 13.6 0.0 0.074 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KII60990.1 - 0.04 13.6 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Zeta_toxin PF06414.7 KII60990.1 - 0.055 12.5 0.0 0.14 11.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin KaiC PF06745.8 KII60990.1 - 0.072 12.1 0.1 6.7 5.7 0.0 2.3 1 1 1 2 2 2 0 KaiC Sigma54_activ_2 PF14532.1 KII60990.1 - 0.08 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 KII60990.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain EMP70 PF02990.11 KII60992.1 - 8.6e-08 31.0 0.4 8.8e-08 31.0 0.3 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 Y_phosphatase PF00102.22 KII60993.1 - 3.3e-70 236.0 2.2 4.5e-70 235.6 1.5 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.19 KII60993.1 - 0.00058 19.6 0.1 0.0015 18.2 0.1 1.8 1 0 0 1 1 1 1 SH2 domain PTPlike_phytase PF14566.1 KII60993.1 - 0.00076 19.5 0.0 0.017 15.1 0.0 2.5 2 0 0 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.15 KII60993.1 - 0.0022 17.5 0.2 0.0064 16.0 0.1 1.9 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 KII60993.1 - 0.02 15.1 0.7 0.097 12.9 0.1 2.5 2 2 1 3 3 3 0 Tyrosine phosphatase family Dynamin_M PF01031.15 KII60996.1 - 3.4e-61 206.6 0.9 4.9e-61 206.0 0.6 1.2 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 KII60996.1 - 1.1e-07 31.8 0.1 2.7e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Dynamin family PH PF00169.24 KII60996.1 - 0.0011 19.1 0.3 0.0026 17.9 0.2 1.8 1 0 0 1 1 1 1 PH domain zf-RING_2 PF13639.1 KII60997.1 - 6.1e-12 45.1 8.0 1.2e-11 44.2 5.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KII60997.1 - 1.2e-07 31.3 7.8 1.2e-07 31.3 5.4 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KII60997.1 - 2.7e-07 30.6 8.0 1.1e-06 28.6 5.6 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 KII60997.1 - 2.9e-07 30.0 6.6 6e-07 29.0 4.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KII60997.1 - 3.9e-07 29.9 8.3 9.7e-07 28.7 5.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KII60997.1 - 0.0019 18.0 5.8 0.0054 16.5 4.0 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 KII60997.1 - 0.0022 17.6 6.7 0.0022 17.6 4.6 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 KII60997.1 - 0.0031 17.3 3.6 0.0072 16.1 2.5 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 KII60997.1 - 0.01 15.5 5.5 0.021 14.5 3.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.3 KII60997.1 - 0.038 13.5 4.8 0.077 12.5 3.3 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.3 KII60997.1 - 0.16 11.9 9.4 1.4 8.8 6.5 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 KII60997.1 - 0.17 11.9 5.0 0.49 10.4 3.4 1.8 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.1 KII60997.1 - 0.46 10.1 3.6 1.7 8.2 2.5 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Ras PF00071.17 KII60998.1 - 3.5e-55 185.8 0.2 4.1e-55 185.6 0.2 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII60998.1 - 8.5e-16 58.5 0.1 1.3e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII60998.1 - 9.8e-13 47.7 0.1 1.2e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KII60998.1 - 1.5e-05 24.2 0.2 1.8e-05 23.9 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KII60998.1 - 0.00041 19.8 0.1 0.0011 18.3 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KII60998.1 - 0.027 14.4 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ras PF00071.17 KII60999.1 - 2.3e-58 196.1 0.6 2.7e-58 195.9 0.4 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII60999.1 - 5.9e-15 55.8 0.1 1.2e-14 54.8 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KII60999.1 - 3.7e-14 52.3 0.0 4.5e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KII60999.1 - 7.7e-09 35.0 0.1 9.7e-09 34.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KII60999.1 - 0.0012 18.8 0.0 0.0015 18.4 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KII60999.1 - 0.0016 17.8 0.0 0.0098 15.3 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 KII60999.1 - 0.003 16.8 0.0 0.005 16.0 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 KII60999.1 - 0.013 15.6 0.0 0.25 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.1 KII60999.1 - 0.022 13.8 0.4 0.027 13.5 0.3 1.2 1 0 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.13 KII60999.1 - 0.022 14.0 0.0 0.13 11.4 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Flu_M1 PF00598.14 KII60999.1 - 0.033 13.5 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 Influenza Matrix protein (M1) Mo-co_dimer PF03404.11 KII61000.1 - 1.1e-35 122.0 0.0 1.3e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain BNR_2 PF13088.1 KII61000.1 - 0.066 12.4 0.0 0.099 11.9 0.0 1.3 1 1 0 1 1 1 0 BNR repeat-like domain BNR PF02012.15 KII61000.1 - 0.29 11.1 0.0 0.29 11.1 0.0 2.6 3 0 0 3 3 3 0 BNR/Asp-box repeat Homeobox PF00046.24 KII61004.1 - 1.6e-20 72.4 3.6 3.3e-20 71.4 2.5 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KII61004.1 - 0.0058 16.2 0.2 0.014 15.0 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain MRP-L20 PF12824.2 KII61004.1 - 0.0061 16.5 1.2 0.013 15.5 0.8 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_28 PF13518.1 KII61004.1 - 0.11 12.5 0.1 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.8 KII61004.1 - 0.14 11.6 0.0 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain YjeF_N PF03853.10 KII61007.1 - 2.2e-34 118.4 0.0 2.9e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus MitMem_reg PF13012.1 KII61008.1 - 5.5e-21 74.7 0.9 9.2e-21 74.0 0.6 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 KII61008.1 - 5.8e-18 64.6 0.0 9.5e-18 64.0 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease ATG11 PF10377.4 KII61009.1 - 0.091 12.6 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 11 Pkinase PF00069.20 KII61010.1 - 2.9e-13 49.5 0.0 3.3e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII61010.1 - 2.9e-08 33.0 0.0 3.3e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 KII61011.1 - 6.1e-07 29.7 0.1 1.2e-06 28.8 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase PF00069.20 KII61011.1 - 0.00099 18.3 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF603 PF04645.7 KII61012.1 - 0.068 13.1 1.5 0.1 12.5 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF603 RraB PF06877.6 KII61012.1 - 0.11 13.0 0.6 0.61 10.7 0.3 2.1 2 0 0 2 2 2 0 Regulator of ribonuclease activity B TetR_C_8 PF14278.1 KII61012.1 - 3 8.3 6.7 1.5 9.2 0.5 2.8 2 1 1 3 3 3 0 Transcriptional regulator C-terminal region EGF_2 PF07974.8 KII61015.1 - 0.0026 17.8 10.5 0.007 16.5 7.3 1.8 1 0 0 1 1 1 1 EGF-like domain OST-HTH PF12872.2 KII61016.1 - 4.7e-07 29.5 0.0 0.00043 20.0 0.0 2.4 2 0 0 2 2 2 2 OST-HTH/LOTUS domain DDE_Tnp_IS1595 PF12762.2 KII61017.1 - 6.2e-18 65.0 0.0 7e-18 64.8 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain Y_phosphatase PF00102.22 KII61019.1 - 1.3e-69 234.1 0.9 1.8e-69 233.6 0.6 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.19 KII61019.1 - 1.8e-07 30.8 0.1 0.0054 16.5 0.0 3.0 3 0 0 3 3 3 2 SH2 domain DSPc PF00782.15 KII61019.1 - 0.0053 16.3 0.0 0.014 15.0 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 KII61019.1 - 0.056 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family zf-UBR PF02207.15 KII61020.1 - 1.4e-16 59.9 11.4 3.7e-16 58.5 7.9 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 KII61020.1 - 0.039 13.6 0.0 0.095 12.4 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS Phage_glycop_gL PF11108.3 KII61021.1 - 0.003 17.4 0.6 0.0051 16.7 0.1 1.6 1 1 1 2 2 2 1 Viral glycoprotein L Arch_fla_DE PF04659.8 KII61021.1 - 0.023 14.4 0.1 0.028 14.2 0.1 1.3 1 0 0 1 1 1 0 Archaeal flagella protein EF-hand_like PF09279.6 KII61021.1 - 0.025 14.5 1.9 3.4 7.7 0.0 2.2 1 1 1 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like YtxH PF12732.2 KII61021.1 - 0.17 12.2 0.2 0.25 11.7 0.1 1.2 1 0 0 1 1 1 0 YtxH-like protein DUF2894 PF11445.3 KII61021.1 - 0.8 9.9 2.8 1.6 8.9 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2894) Dynamin_M PF01031.15 KII61022.1 - 9.7e-62 208.4 0.7 2.4e-34 118.4 0.1 2.2 2 0 0 2 2 2 2 Dynamin central region Dynamin_N PF00350.18 KII61022.1 - 9.2e-47 158.9 0.0 2e-46 157.8 0.0 1.6 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KII61022.1 - 0.0028 17.6 0.5 0.013 15.4 0.1 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 KII61022.1 - 0.051 14.0 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein GDPD_2 PF13653.1 KII61022.1 - 0.1 12.8 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family GED PF02212.13 KII61023.1 - 0.083 12.7 0.5 0.13 12.1 0.3 1.3 1 0 0 1 1 1 0 Dynamin GTPase effector domain rve PF00665.21 KII61026.1 - 2.8e-25 88.7 0.0 8.7e-25 87.1 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII61026.1 - 2.2e-18 66.4 0.0 2e-17 63.2 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII61026.1 - 2.3e-06 26.9 0.1 7.1e-06 25.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RICH PF05062.7 KII61026.1 - 0.15 12.2 3.7 0.6 10.2 1.0 2.6 2 0 0 2 2 2 0 RICH domain Fumarate_red_D PF02313.12 KII61028.1 - 0.051 13.4 0.1 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 Fumarate reductase subunit D Asp_protease_2 PF13650.1 KII61030.1 - 4.3e-07 30.3 0.0 9.3e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII61030.1 - 3.1e-05 23.7 1.0 9.6e-05 22.2 0.1 2.2 3 0 0 3 3 3 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII61030.1 - 0.00019 21.2 0.0 0.00053 19.7 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII61030.1 - 0.0013 18.5 5.8 0.003 17.3 1.2 2.6 2 0 0 2 2 2 1 Zinc knuckle DUF1843 PF08898.5 KII61031.1 - 0.13 12.3 0.4 0.35 10.9 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) Rgp1 PF08737.5 KII61031.1 - 0.63 9.0 7.4 1.5 7.7 5.1 1.5 1 1 0 1 1 1 0 Rgp1 PsaA_PsaB PF00223.14 KII61034.1 - 0.056 11.5 0.0 0.066 11.2 0.0 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein Chromosome_seg PF13889.1 KII61037.1 - 0.13 12.1 0.9 1.3 8.9 0.1 2.6 2 0 0 2 2 2 0 Chromosome segregation during meiosis Phage_connect_1 PF05135.8 KII61038.1 - 0.066 13.3 1.9 0.095 12.8 1.3 1.3 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein L_lactis_RepB_C PF06430.7 KII61038.1 - 0.11 12.5 0.8 0.16 12.0 0.6 1.4 1 1 0 1 1 1 0 Lactococcus lactis RepB C-terminus SNAP PF14938.1 KII61039.1 - 4e-06 26.1 10.3 5.4e-06 25.7 7.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Pox_polyA_pol_N PF12630.2 KII61039.1 - 0.12 12.4 0.2 0.12 12.4 0.1 2.5 2 1 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain TPR_2 PF07719.12 KII61039.1 - 6.6 6.9 13.6 6.2 7.0 0.1 5.2 4 2 2 6 6 6 0 Tetratricopeptide repeat Ldl_recept_a PF00057.13 KII61041.1 - 1.6e-15 56.6 50.7 2.5e-09 36.8 7.6 3.2 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Crisp PF08562.5 KII61041.1 - 6.1 7.1 35.6 1.3 9.3 7.2 3.1 2 1 1 3 3 3 0 Crisp Nucleoplasmin PF03066.10 KII61043.1 - 5.2e-30 103.9 1.4 5.2e-30 103.9 0.9 3.0 1 1 1 2 2 2 1 Nucleoplasmin SAPS PF04499.10 KII61043.1 - 0.019 13.6 10.1 0.026 13.1 7.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.7 KII61043.1 - 0.035 12.0 24.9 0.042 11.7 17.2 1.1 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.7 KII61043.1 - 0.59 9.9 13.4 0.9 9.3 9.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ebola_NP PF05505.7 KII61043.1 - 0.76 7.7 11.8 0.99 7.3 8.2 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein YL1 PF05764.8 KII61043.1 - 2.7 7.5 23.7 4.7 6.7 16.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein BNR PF02012.15 KII61044.1 - 0.00054 19.3 5.8 1.2 9.2 0.1 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR PF02012.15 KII61047.1 - 0.31 11.0 9.2 3.7 7.7 2.7 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat TMEM154 PF15102.1 KII61048.1 - 0.17 11.5 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family SR-25 PF10500.4 KII61049.1 - 1.8 8.0 10.2 2 7.7 1.5 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-UBP PF02148.14 KII61055.1 - 0.051 13.6 2.2 0.087 12.9 1.5 1.4 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-C2H2_jaz PF12171.3 KII61055.1 - 0.21 11.7 3.3 2.9 8.1 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF4457 PF14652.1 KII61056.1 - 0.052 12.5 0.1 0.063 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) RVT_1 PF00078.22 KII61057.1 - 0.026 13.8 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII61058.1 - 0.018 15.1 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain zf-3CxxC PF13695.1 KII61058.1 - 0.048 13.8 0.5 0.061 13.5 0.4 1.4 1 1 0 1 1 1 0 Zinc-binding domain PUA PF01472.15 KII61062.1 - 4e-21 74.5 0.9 8.2e-21 73.5 0.6 1.6 1 0 0 1 1 1 1 PUA domain DUF1168 PF06658.7 KII61063.1 - 3.2e-19 68.8 8.4 4.9e-19 68.2 5.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Vma12 PF11712.3 KII61063.1 - 0.17 11.5 1.2 0.17 11.5 0.8 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2951 PF11166.3 KII61063.1 - 0.32 10.8 9.7 0.62 9.9 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF3490 PF11995.3 KII61063.1 - 0.58 9.6 9.8 0.86 9.1 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) Acyltransferase PF01553.16 KII61064.1 - 1.4e-14 53.6 0.0 2.1e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase WND PF07861.6 KII61064.1 - 0.17 10.8 0.1 0.26 10.2 0.1 1.2 1 0 0 1 1 1 0 WisP family N-Terminal Region SEO_C PF14577.1 KII61068.1 - 0.064 12.6 0.1 0.072 12.4 0.0 1.1 1 0 0 1 1 1 0 Sieve element occlusion C-terminus Dynamin_N PF00350.18 KII61069.1 - 0.0094 15.7 0.3 0.013 15.2 0.2 1.2 1 0 0 1 1 1 1 Dynamin family Sin3_corepress PF08295.7 KII61069.1 - 0.051 13.3 0.4 0.092 12.5 0.3 1.4 1 0 0 1 1 1 0 Sin3 family co-repressor RVT_1 PF00078.22 KII61070.1 - 6.5e-09 35.4 0.0 7.1e-09 35.3 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.9 KII61070.1 - 0.12 11.2 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_IS1595 PF12762.2 KII61072.1 - 6.3e-10 39.0 0.0 2.4e-09 37.1 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII61074.1 - 6.9e-11 42.0 0.0 1.1e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2024 PF09630.5 KII61074.1 - 0.13 12.0 0.1 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) DDE_3 PF13358.1 KII61076.1 - 3.6e-14 52.7 0.1 4.4e-14 52.4 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease bZIP_1 PF00170.16 KII61078.1 - 1.2e-11 44.3 8.8 1.7e-11 43.8 6.1 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KII61078.1 - 2e-06 27.4 9.8 2.9e-06 27.0 6.6 1.4 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 KII61078.1 - 0.014 15.7 7.0 0.02 15.1 4.9 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor Tim44 PF04280.10 KII61079.1 - 2.6e-05 24.2 0.0 3.7e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Tim44-like domain Nyv1_N PF09426.5 KII61079.1 - 0.011 15.2 0.1 0.023 14.2 0.0 1.4 1 1 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal Cpn60_TCP1 PF00118.19 KII61080.1 - 7.1e-149 496.5 8.8 8.2e-149 496.3 6.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRS1_YhbY PF01985.16 KII61080.1 - 0.035 14.1 0.5 0.31 11.0 0.2 2.7 4 0 0 4 4 4 0 CRS1 / YhbY (CRM) domain SMC_Nse1 PF07574.8 KII61081.1 - 2.1e-12 47.0 1.1 3.1e-12 46.5 0.5 1.4 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 KII61081.1 - 0.00046 20.1 13.6 0.00077 19.4 9.4 1.4 1 0 0 1 1 1 1 RING-like domain C1_1 PF00130.17 KII61081.1 - 0.011 15.4 7.9 0.011 15.4 5.5 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3349 PF11829.3 KII61081.1 - 0.017 15.5 0.3 0.052 13.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) Rpr2 PF04032.11 KII61081.1 - 0.049 13.4 7.3 0.15 11.9 5.1 1.8 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain MutS_III PF05192.13 KII61081.1 - 0.055 13.2 0.3 0.076 12.7 0.2 1.2 1 0 0 1 1 1 0 MutS domain III APG5 PF04106.7 KII61081.1 - 0.06 12.8 1.1 0.076 12.4 0.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg5 EcoEI_R_C PF08463.5 KII61081.1 - 0.11 12.3 2.9 1.3 8.8 2.0 2.4 1 1 0 1 1 1 0 EcoEI R protein C-terminal PHD PF00628.24 KII61081.1 - 0.72 9.5 12.2 1.2 8.8 8.5 1.4 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 KII61081.1 - 4.9 6.9 12.1 24 4.7 8.5 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 WD40 PF00400.27 KII61082.1 - 0.12 12.3 0.0 0.52 10.2 0.0 2.1 2 0 0 2 2 2 0 WD domain, G-beta repeat WD40 PF00400.27 KII61083.1 - 0.00015 21.4 0.6 0.12 12.2 0.7 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat ALIX_LYPXL_bnd PF13949.1 KII61084.1 - 3.8e-30 104.8 8.3 3.8e-30 104.8 5.8 2.2 3 0 0 3 3 3 1 ALIX V-shaped domain binding to HIV BRO1 PF03097.13 KII61084.1 - 1.8e-27 96.0 0.1 1.8e-27 96.0 0.1 1.8 2 0 0 2 2 2 1 BRO1-like domain COG5 PF10392.4 KII61084.1 - 0.069 13.1 6.1 0.059 13.3 1.0 3.0 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Peptidase_M22 PF00814.20 KII61085.1 - 9.5e-49 166.2 0.0 1.5e-48 165.6 0.0 1.3 1 0 0 1 1 1 1 Glycoprotease family TAP42 PF04177.7 KII61088.1 - 3.6e-46 157.6 9.4 3.1e-45 154.6 6.5 1.9 1 1 0 1 1 1 1 TAP42-like family Ski_Sno PF02437.12 KII61088.1 - 0.051 13.1 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 SKI/SNO/DAC family ECIST_Cterm PF14784.1 KII61088.1 - 0.67 9.9 4.4 0.41 10.5 0.2 2.4 2 1 0 2 2 2 0 C-terminal domain of the ECSIT protein FragX_IP PF05994.6 KII61091.1 - 2.7e-127 425.7 20.7 3.5e-127 425.3 14.4 1.1 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family CCG PF02754.11 KII61091.1 - 0.061 13.3 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Cysteine-rich domain C2 PF00168.25 KII61093.1 - 2.3e-09 36.9 0.1 4.9e-09 35.9 0.1 1.6 1 0 0 1 1 1 1 C2 domain tRNA-synt_1d PF00750.14 KII61094.1 - 4e-105 351.5 0.2 5.8e-105 350.9 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 KII61094.1 - 5.6e-21 74.6 0.0 1.7e-20 73.1 0.0 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 KII61094.1 - 2.1e-08 34.6 0.0 5.4e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.14 KII61094.1 - 0.0022 17.1 0.0 0.004 16.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain EF-hand_8 PF13833.1 KII61094.1 - 0.066 12.8 0.0 37 4.0 0.0 3.4 3 0 0 3 3 3 0 EF-hand domain pair DUF1838 PF08894.6 KII61094.1 - 0.15 11.2 0.3 18 4.4 0.0 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF1838) SRI PF08236.6 KII61095.1 - 0.0095 15.8 1.4 0.013 15.4 1.0 1.4 1 1 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain ICE2 PF08426.5 KII61095.1 - 0.071 11.7 0.2 0.079 11.5 0.1 1.0 1 0 0 1 1 1 0 ICE2 LRR_4 PF12799.2 KII61097.1 - 1.9e-26 91.1 56.8 1.8e-10 40.2 3.9 4.7 2 2 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KII61097.1 - 3.8e-24 84.2 44.3 3e-10 39.6 4.3 3.6 2 2 2 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 KII61097.1 - 1.5e-14 51.7 28.4 0.012 15.5 0.0 7.0 7 0 0 7 7 7 6 Leucine Rich Repeat LRR_7 PF13504.1 KII61097.1 - 1.8e-08 33.2 20.5 0.94 9.9 0.4 7.0 7 0 0 7 7 7 3 Leucine rich repeat LRR_6 PF13516.1 KII61097.1 - 8e-05 22.3 27.7 0.086 12.9 1.2 6.4 5 1 1 6 6 6 4 Leucine Rich repeat LRR_9 PF14580.1 KII61097.1 - 0.00086 18.9 11.7 0.00092 18.8 1.7 2.9 1 1 2 3 3 3 2 Leucine-rich repeat Pkinase PF00069.20 KII61098.1 - 8e-28 97.2 0.0 3.4e-21 75.5 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KII61098.1 - 1.3e-27 96.5 0.0 1.1e-20 73.8 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase DUF2318 PF10080.4 KII61099.1 - 0.0018 18.0 2.2 0.01 15.5 0.2 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2318) DUF1451 PF07295.6 KII61099.1 - 0.025 14.3 4.1 0.1 12.3 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1451) Elf1 PF05129.8 KII61099.1 - 0.16 11.6 10.9 0.22 11.2 0.2 3.0 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like zinc_ribbon_6 PF14599.1 KII61099.1 - 0.21 11.3 5.5 0.61 9.9 0.9 2.2 2 0 0 2 2 2 0 Zinc-ribbon PHD PF00628.24 KII61099.1 - 1.1 9.0 10.4 3.4 7.4 2.1 2.4 2 0 0 2 2 2 0 PHD-finger DUF4182 PF13790.1 KII61099.1 - 2.6 7.9 7.1 0.46 10.3 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4182) C1_1 PF00130.17 KII61099.1 - 4.1 7.2 9.9 6.6 6.5 0.2 2.5 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) L71 PF02448.10 KII61099.1 - 7.1 6.5 8.7 1.1 9.0 2.2 2.0 2 0 0 2 2 2 0 L71 family DnaI_N PF07319.6 KII61100.1 - 0.0087 16.2 0.4 0.019 15.2 0.3 1.6 1 0 0 1 1 1 1 Primosomal protein DnaI N-terminus RBD PF02196.10 KII61100.1 - 0.023 14.4 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 Raf-like Ras-binding domain DUF262 PF03235.9 KII61100.1 - 0.057 13.3 2.2 0.098 12.6 1.5 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF262 DUF2205 PF10224.4 KII61100.1 - 0.31 10.6 4.5 0.059 12.9 0.6 1.7 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) YIF1 PF03878.10 KII61101.1 - 3e-28 98.6 2.2 3.6e-28 98.3 1.5 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 KII61101.1 - 0.0085 15.6 0.1 0.012 15.1 0.1 1.2 1 0 0 1 1 1 1 Yip1 domain Nop53 PF07767.6 KII61102.1 - 6.4e-10 38.5 7.8 7.2e-10 38.4 5.4 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Muted PF14942.1 KII61102.1 - 0.0078 16.0 1.2 0.0078 16.0 0.8 1.4 1 1 0 1 1 1 1 Organelle biogenesis, Muted-like protein DUF3381 PF11861.3 KII61102.1 - 0.016 14.7 8.2 0.019 14.4 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF1053 PF06327.9 KII61102.1 - 0.91 9.9 5.0 7.6 6.9 3.2 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1053) DUF2951 PF11166.3 KII61102.1 - 1.1 9.2 6.1 0.13 12.1 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) PRP1_N PF06424.7 KII61102.1 - 2.9 8.2 8.6 4.8 7.5 5.5 1.7 1 1 1 2 2 2 0 PRP1 splicing factor, N-terminal GST_C PF00043.20 KII61103.1 - 2.5e-08 33.8 0.0 4.4e-08 33.0 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KII61103.1 - 3.8e-08 33.7 0.0 5.1e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KII61103.1 - 1e-06 28.7 0.0 2.2e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KII61103.1 - 0.0012 18.7 0.0 0.0024 17.7 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KII61103.1 - 0.05 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Far-17a_AIG1 PF04750.9 KII61104.1 - 0.0078 15.3 0.5 0.0094 15.1 0.4 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Srg PF02118.16 KII61104.1 - 0.028 13.8 5.0 0.032 13.6 3.4 1.1 1 0 0 1 1 1 0 Srg family chemoreceptor DUF4231 PF14015.1 KII61104.1 - 0.11 12.4 2.5 0.12 12.3 1.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Nramp PF01566.13 KII61104.1 - 0.19 10.4 5.9 0.079 11.7 1.6 1.7 1 1 1 2 2 2 0 Natural resistance-associated macrophage protein DUF3533 PF12051.3 KII61104.1 - 0.31 9.7 4.5 0.31 9.7 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) MFS_1 PF07690.11 KII61105.1 - 4e-16 58.6 9.1 4.5e-16 58.4 6.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KII61105.1 - 2.2e-06 26.5 4.2 2.3e-06 26.4 2.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.15 KII61105.1 - 0.0006 17.9 6.1 0.025 12.6 1.2 2.0 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.1 KII61105.1 - 0.00083 17.8 4.8 0.0013 17.2 3.3 1.3 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_3 PF05977.8 KII61105.1 - 0.0082 14.3 0.8 0.0092 14.1 0.6 1.1 1 0 0 1 1 1 1 Transmembrane secretion effector C1_1 PF00130.17 KII61108.1 - 0.00011 21.8 12.3 0.0002 21.0 8.5 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) CDC37_C PF08564.5 KII61109.1 - 5e-23 80.8 0.8 5e-23 80.8 0.6 1.7 1 1 1 2 2 2 1 Cdc37 C terminal domain Autophagy_N PF03986.8 KII61109.1 - 0.17 11.6 5.8 0.028 14.1 1.2 1.7 2 0 0 2 2 2 0 Autophagocytosis associated protein (Atg3), N-terminal domain Utp11 PF03998.8 KII61110.1 - 2.6e-27 96.2 34.3 2.9e-25 89.4 9.1 2.1 1 1 1 2 2 2 2 Utp11 protein Prominin PF05478.6 KII61110.1 - 0.055 11.0 3.2 0.071 10.6 2.2 1.1 1 0 0 1 1 1 0 Prominin DUF3373 PF11853.3 KII61110.1 - 0.075 11.5 5.0 0.097 11.1 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) FlxA PF14282.1 KII61110.1 - 0.35 10.8 10.4 0.7 9.8 7.2 1.5 1 0 0 1 1 1 0 FlxA-like protein FlaC_arch PF05377.6 KII61110.1 - 1.8 8.5 6.7 0.31 10.9 1.8 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2756 PF10956.3 KII61110.1 - 4.2 7.6 9.6 0.52 10.5 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2756) DUF4337 PF14235.1 KII61110.1 - 4.4 7.1 16.9 0.13 12.1 5.4 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4337) V_ATPase_I PF01496.14 KII61110.1 - 5.5 4.7 12.6 4.3 5.0 7.9 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.7 KII61110.1 - 5.8 6.6 19.6 11 5.8 12.5 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1925 PF09094.6 KII61110.1 - 6.1 6.9 7.3 0.74 9.8 0.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1925) Aa_trans PF01490.13 KII61111.1 - 1.7e-41 142.1 54.4 1.9e-41 141.9 37.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KII61111.1 - 2.2e-07 30.0 47.8 3.5e-07 29.3 33.2 1.4 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Med26 PF08711.6 KII61112.1 - 1.1e-10 40.8 2.1 2e-10 40.0 1.4 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain LEDGF PF11467.3 KII61112.1 - 0.0053 16.4 0.2 0.009 15.6 0.1 1.3 1 0 0 1 1 1 1 Lens epithelium-derived growth factor (LEDGF) HrcA PF01628.16 KII61112.1 - 0.078 12.5 0.5 0.12 11.9 0.3 1.2 1 0 0 1 1 1 0 HrcA protein C terminal domain HeLo PF14479.1 KII61113.1 - 0.083 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF775 PF05603.7 KII61114.1 - 0.023 14.1 3.3 0.034 13.6 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Daxx PF03344.10 KII61114.1 - 1.6 7.1 26.4 2.1 6.7 18.3 1.2 1 0 0 1 1 1 0 Daxx Family THRAP3_BCLAF1 PF15440.1 KII61114.1 - 3 6.3 16.9 4.4 5.8 11.7 1.2 1 0 0 1 1 1 0 THRAP3/BCLAF1 family WD40 PF00400.27 KII61115.1 - 1.1e-28 97.9 26.0 1.5e-07 31.0 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat PDR_CDR PF06422.7 KII61116.1 - 3.5 7.3 5.1 2.6 7.7 1.2 2.4 2 0 0 2 2 2 0 CDR ABC transporter DUF1825 PF08855.5 KII61117.1 - 0.0022 17.9 5.1 0.0022 17.9 3.5 3.4 2 1 1 4 4 4 1 Domain of unknown function (DUF1825) HsbA PF12296.3 KII61117.1 - 0.0082 15.9 1.6 0.26 11.1 0.1 3.2 3 0 0 3 3 3 1 Hydrophobic surface binding protein A PuR_N PF09182.5 KII61117.1 - 0.033 13.8 0.1 0.088 12.4 0.1 1.7 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal DUF2937 PF11157.3 KII61117.1 - 0.11 11.8 4.3 0.53 9.5 0.1 3.4 3 2 1 4 4 4 0 Protein of unknown function (DUF2937) DUF948 PF06103.6 KII61117.1 - 0.41 10.5 18.3 1.2 9.0 0.2 4.8 2 1 3 5 5 5 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.7 KII61117.1 - 4.6 7.6 24.0 1.5 9.2 0.2 5.6 4 2 1 6 6 6 0 SlyX Na_K-ATPase PF00287.13 KII61118.1 - 1.6e-06 27.1 0.7 0.0047 15.7 0.2 3.0 1 1 2 3 3 3 3 Sodium / potassium ATPase beta chain But2 PF09792.4 KII61118.1 - 0.058 13.1 0.0 0.091 12.5 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin 3 binding protein But2 C-terminal domain BNR PF02012.15 KII61119.1 - 0.00039 19.8 5.3 2.7 8.1 0.1 4.5 4 0 0 4 4 4 3 BNR/Asp-box repeat Toxin_24 PF08094.6 KII61119.1 - 0.22 11.1 3.6 0.4 10.3 2.5 1.4 1 0 0 1 1 1 0 Conotoxin TVIIA/GS family DDE_3 PF13358.1 KII61121.1 - 2.5e-15 56.4 0.0 3.5e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Aldo_ket_red PF00248.16 KII61122.1 - 6.4e-26 90.8 0.0 7.2e-26 90.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Corona_S2 PF01601.11 KII61123.1 - 0.01 13.9 0.0 0.01 13.9 0.0 1.0 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein RAG1 PF12940.2 KII61123.1 - 0.011 14.0 0.1 0.014 13.7 0.1 1.1 1 0 0 1 1 1 0 Recombination-activation protein 1 (RAG1) Arc_PepC_II PF06847.6 KII61123.1 - 0.013 15.9 1.1 0.021 15.2 0.8 1.4 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II NnrU PF07298.6 KII61123.1 - 0.026 13.8 1.9 0.033 13.5 1.3 1.1 1 0 0 1 1 1 0 NnrU protein ATPase_gene1 PF09527.5 KII61123.1 - 0.24 11.2 2.1 0.41 10.4 1.4 1.4 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit (ATPase_gene1) Shisa PF13908.1 KII61125.1 - 0.039 14.1 0.1 0.055 13.6 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM154 PF15102.1 KII61125.1 - 0.1 12.3 0.3 0.14 11.8 0.2 1.2 1 0 0 1 1 1 0 TMEM154 protein family Adeno_E3 PF06040.6 KII61125.1 - 0.19 11.7 3.2 0.27 11.2 2.2 1.2 1 0 0 1 1 1 0 Adenovirus E3 protein Calcyon PF06387.6 KII61125.1 - 0.54 9.6 1.9 0.71 9.2 1.3 1.1 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Aldo_ket_red PF00248.16 KII61126.1 - 7.1e-05 21.7 0.0 7.1e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family RecX PF02631.11 KII61128.1 - 0.12 12.6 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 RecX family Claudin_3 PF06653.6 KII61129.1 - 1.3 8.6 10.1 1.4 8.6 7.0 1.1 1 0 0 1 1 1 0 Tight junction protein, Claudin-like YukC PF10140.4 KII61129.1 - 9.8 4.6 7.0 0.34 9.4 0.9 1.4 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC rve PF00665.21 KII61135.1 - 1.3e-07 31.7 0.0 2.4e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII61135.1 - 0.0016 17.8 0.0 0.0036 16.6 0.0 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger zf-CCHC PF00098.18 KII61136.1 - 0.0047 16.7 0.3 0.0071 16.2 0.2 1.3 1 0 0 1 1 1 1 Zinc knuckle EB1 PF03271.12 KII61136.1 - 0.054 13.5 0.1 0.087 12.8 0.0 1.4 1 0 0 1 1 1 0 EB1-like C-terminal motif Dynein_heavy PF03028.10 KII61137.1 - 0.0071 14.4 0.0 0.008 14.2 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Glyco_hydro_63 PF03200.11 KII61138.1 - 0.042 11.6 0.1 0.048 11.5 0.0 1.1 1 0 0 1 1 1 0 Mannosyl oligosaccharide glucosidase MSA-2c PF12238.3 KII61140.1 - 0.42 10.2 3.7 0.57 9.8 2.6 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c zf-CCHC PF00098.18 KII61141.1 - 0.88 9.6 4.6 1.7 8.7 3.2 1.5 1 0 0 1 1 1 0 Zinc knuckle AAA_9 PF12781.2 KII61142.1 - 0.049 12.4 0.4 0.062 12.1 0.3 1.1 1 0 0 1 1 1 0 ATP-binding dynein motor region D5 DUF1031 PF06275.6 KII61142.1 - 2.9 7.9 7.1 2.1 8.4 1.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) FliD_C PF07195.7 KII61143.1 - 0.12 11.6 0.1 0.15 11.3 0.1 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus SusD-like_3 PF14322.1 KII61144.1 - 0.028 14.4 0.3 0.041 13.9 0.2 1.3 1 0 0 1 1 1 0 Starch-binding associating with outer membrane DUF1180 PF06679.7 KII61144.1 - 0.11 12.3 0.1 0.17 11.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Pox_A14 PF05767.7 KII61145.1 - 0.08 12.9 2.4 2.6 8.0 0.1 2.8 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 SNAP PF14938.1 KII61147.1 - 1.1e-07 31.3 2.3 1.1e-07 31.3 1.6 2.0 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP Phage_X PF05155.10 KII61147.1 - 0.092 12.6 0.1 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Phage X family ETC_C1_NDUFA5 PF04716.9 KII61147.1 - 0.1 12.1 0.2 0.22 11.0 0.2 1.5 1 0 0 1 1 1 0 ETC complex I subunit conserved region BNR PF02012.15 KII61149.1 - 3.1e-05 23.1 0.2 2.6 8.2 0.0 3.9 3 0 0 3 3 3 2 BNR/Asp-box repeat SH2 PF00017.19 KII61150.1 - 8.2e-06 25.5 0.1 1.3e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 SH2 domain Fer4_12 PF13353.1 KII61150.1 - 0.033 14.2 0.1 0.039 14.0 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S single cluster domain Integrin_beta PF00362.13 KII61151.1 - 1.5e-27 96.5 0.0 1.9e-27 96.2 0.0 1.0 1 0 0 1 1 1 1 Integrin, beta chain PSI PF01437.20 KII61151.1 - 0.0074 16.4 0.2 0.013 15.5 0.1 1.4 1 0 0 1 1 1 1 Plexin repeat Kelch_4 PF13418.1 KII61152.1 - 7e-20 70.5 13.4 1.4e-05 24.7 0.1 5.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KII61152.1 - 1.7e-19 69.0 17.0 0.0013 18.8 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 KII61152.1 - 2e-19 69.1 3.9 0.0016 18.5 0.0 7.1 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII61152.1 - 1.4e-18 66.1 12.4 0.0011 18.4 0.1 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.1 KII61152.1 - 3.5e-12 45.9 14.4 0.06 13.3 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KII61152.1 - 1.1e-10 40.8 13.8 0.016 14.9 0.0 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 KII61153.1 - 1.1e-24 85.4 22.6 8.2e-08 32.0 0.1 6.3 4 2 2 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KII61153.1 - 4.3e-17 61.3 13.0 7.5e-06 25.3 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 KII61153.1 - 3.5e-16 58.8 11.5 2.7e-05 24.1 0.0 5.7 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 KII61153.1 - 1.7e-15 56.4 19.2 9.7e-05 22.0 0.1 6.2 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII61153.1 - 5.8e-08 32.5 18.0 0.33 10.9 0.0 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KII61153.1 - 0.0032 17.1 18.3 0.13 12.1 0.0 5.8 6 1 0 6 6 6 3 Kelch motif Kelch_6 PF13964.1 KII61154.1 - 1.2e-05 25.3 1.9 0.00099 19.1 0.1 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII61154.1 - 4e-05 23.1 0.3 0.00052 19.6 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.20 KII61154.1 - 7.4e-05 22.2 4.0 0.032 13.7 1.2 2.5 2 1 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 KII61154.1 - 0.00086 19.4 0.4 0.01 16.0 0.1 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KII61154.1 - 0.0021 17.7 1.0 0.14 11.9 0.1 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain DUF1342 PF07072.6 KII61154.1 - 0.094 12.3 0.1 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) Kelch_6 PF13964.1 KII61155.1 - 1.9e-13 49.9 6.1 0.00088 19.3 0.2 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII61155.1 - 4.9e-09 35.5 6.8 0.00013 21.4 0.7 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII61155.1 - 4e-08 32.8 1.5 0.0039 16.9 0.0 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII61155.1 - 3e-06 27.0 3.8 0.0013 18.5 0.2 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 KII61155.1 - 8.3e-06 25.8 2.4 1.3 9.2 0.0 3.8 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII61155.1 - 2.4e-05 23.8 1.1 0.95 9.3 0.1 3.3 3 0 0 3 3 3 2 Kelch motif DUF4395 PF14340.1 KII61155.1 - 0.041 13.9 0.0 0.061 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4395) L-fibroin PF05849.6 KII61155.1 - 0.095 12.0 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) Kelch_1 PF01344.20 KII61156.1 - 1.2e-12 47.1 11.0 1.2e-06 27.9 0.4 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 KII61156.1 - 4.3e-12 45.6 7.2 0.00015 21.7 0.2 3.1 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII61156.1 - 1.2e-11 44.3 1.9 0.00042 20.4 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.1 KII61156.1 - 2.3e-11 43.2 3.0 0.00033 20.3 0.0 3.1 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KII61156.1 - 8e-10 38.4 7.2 0.00072 19.4 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII61156.1 - 1.1e-09 37.6 4.4 0.0046 16.6 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Rax2 PF12768.2 KII61156.1 - 0.022 14.0 0.1 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity RAG2 PF03089.9 KII61156.1 - 0.027 13.2 0.2 1.2 7.8 0.0 2.0 1 1 1 2 2 2 0 Recombination activating protein 2 Toxin_23 PF08093.6 KII61156.1 - 1.9 8.4 5.5 7.5 6.5 0.5 2.7 2 0 0 2 2 2 0 Magi 5 toxic peptide family DUF3861 PF12977.2 KII61157.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3861) DUF3780 PF12635.2 KII61157.1 - 0.12 11.8 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3780) DDE_3 PF13358.1 KII61158.1 - 3.6e-27 94.9 0.0 6.3e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII61158.1 - 1.7e-08 34.5 0.0 4e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII61158.1 - 5.2e-07 30.3 0.3 2.2e-06 28.3 0.0 2.2 3 0 0 3 3 2 1 Homeodomain-like domain HTH_23 PF13384.1 KII61158.1 - 5.2e-07 29.1 0.2 5.8e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.13 KII61158.1 - 9.3e-06 25.3 0.2 1.7e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_33 PF13592.1 KII61158.1 - 1.1e-05 24.8 0.0 4.7e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.1 KII61158.1 - 0.00011 22.1 0.1 0.0061 16.5 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain DUF1323 PF07037.6 KII61158.1 - 0.00017 21.7 0.6 0.002 18.2 0.1 2.7 2 1 0 2 2 2 1 Putative transcription regulator (DUF1323) CENP-B_N PF04218.8 KII61158.1 - 0.00076 18.8 0.1 0.0026 17.1 0.1 1.9 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_IS630 PF01710.11 KII61158.1 - 0.0035 17.0 0.3 0.0056 16.3 0.2 1.3 1 0 0 1 1 1 1 Transposase TrmB PF01978.14 KII61158.1 - 0.029 14.0 0.0 0.088 12.5 0.0 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_Tnp_Tc3_2 PF01498.13 KII61158.1 - 0.048 13.7 2.5 0.13 12.2 0.1 2.5 3 0 0 3 3 3 0 Transposase Arg_repressor PF01316.16 KII61158.1 - 0.084 12.4 1.0 0.75 9.3 0.0 2.6 3 0 0 3 3 3 0 Arginine repressor, DNA binding domain Kelch_6 PF13964.1 KII61159.1 - 2.1e-15 56.1 11.6 0.0098 16.0 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KII61159.1 - 2.3e-12 46.2 12.9 0.0049 16.3 0.1 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 KII61159.1 - 3.1e-09 36.7 6.7 0.028 14.5 0.0 6.3 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII61159.1 - 7.3e-07 28.8 20.2 0.0042 16.8 0.1 6.8 6 1 1 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII61159.1 - 4.9e-06 26.3 6.3 0.0071 16.2 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 KII61159.1 - 0.0037 16.9 15.0 0.13 12.0 0.1 6.3 6 2 0 6 6 6 1 Kelch motif DUF4611 PF15387.1 KII61159.1 - 0.044 13.9 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Kelch_1 PF01344.20 KII61160.1 - 6.5e-15 54.3 4.0 2.2e-07 30.2 0.2 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 KII61160.1 - 7.1e-12 44.9 4.4 1.4e-05 25.0 0.2 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII61160.1 - 2.1e-09 37.0 1.2 4.9e-05 23.0 0.1 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII61160.1 - 3.4e-09 36.0 3.7 0.0007 19.2 0.3 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.1 KII61160.1 - 1.2e-06 28.2 4.6 0.00011 22.1 0.4 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 KII61160.1 - 0.002 18.2 0.9 1.9 8.7 0.0 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_4 PF13418.1 KII61161.1 - 0.00066 19.3 0.7 0.0015 18.2 0.5 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_3 PF13415.1 KII61161.1 - 0.069 13.3 1.8 0.24 11.5 0.1 2.4 1 1 1 2 2 2 0 Galactose oxidase, central domain NOC3p PF07540.6 KII61162.1 - 0.1 12.8 0.1 0.69 10.2 0.1 2.0 1 1 0 1 1 1 0 Nucleolar complex-associated protein HEPN PF05168.9 KII61162.1 - 0.11 12.3 0.1 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 HEPN domain Kelch_6 PF13964.1 KII61163.1 - 2.1e-26 90.9 15.4 4e-07 29.9 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 KII61163.1 - 8.4e-19 67.2 11.5 1.7e-06 27.9 0.1 6.3 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII61163.1 - 1.6e-18 65.9 20.2 1.1e-05 24.8 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII61163.1 - 5.9e-16 57.9 17.4 0.00052 19.7 0.1 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KII61163.1 - 5.1e-12 45.4 15.7 0.011 15.7 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KII61163.1 - 8.8e-05 22.1 18.4 0.031 14.0 0.0 6.2 6 1 0 6 6 6 3 Kelch motif DDE_3 PF13358.1 KII61164.1 - 2e-19 69.7 0.0 2.2e-19 69.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3766 PF12611.3 KII61164.1 - 0.19 11.2 1.5 2 7.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3766) HTH_Tnp_Tc3_2 PF01498.13 KII61165.1 - 0.00051 20.0 0.2 0.00098 19.1 0.1 1.5 1 0 0 1 1 1 1 Transposase CENP-B_N PF04218.8 KII61165.1 - 0.012 15.0 0.6 1 8.8 0.0 2.8 3 0 0 3 3 3 0 CENP-B N-terminal DNA-binding domain AAA-ATPase_like PF09820.4 KII61165.1 - 0.03 13.4 1.5 0.037 13.2 1.0 1.0 1 0 0 1 1 1 0 Predicted AAA-ATPase Kelch_6 PF13964.1 KII61166.1 - 7.8e-15 54.3 10.6 2.8e-05 24.0 0.4 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.1 KII61166.1 - 9.7e-10 38.0 14.1 8.2e-05 22.2 0.0 4.9 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII61166.1 - 1.2e-08 34.3 13.5 0.0024 17.3 0.1 5.4 5 1 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 KII61166.1 - 6.2e-07 29.4 5.4 0.71 10.1 0.0 4.8 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII61166.1 - 2.6e-06 27.2 5.6 0.11 12.4 0.0 4.6 5 0 0 5 5 5 3 Kelch motif Rax2 PF12768.2 KII61166.1 - 0.00038 19.7 0.1 0.00063 19.0 0.1 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Kelch_2 PF07646.10 KII61166.1 - 0.0013 18.3 8.1 0.44 10.3 0.1 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.1 KII61167.1 - 2e-31 107.5 12.4 2.3e-06 27.2 0.0 6.2 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 KII61167.1 - 3.8e-25 86.9 18.9 0.0001 22.3 0.1 6.2 5 1 1 6 6 6 6 Kelch motif Kelch_3 PF13415.1 KII61167.1 - 4.4e-20 71.2 8.3 0.00073 19.6 0.1 6.9 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII61167.1 - 1.1e-16 60.0 29.7 1.6e-05 24.3 0.1 6.7 6 1 0 6 6 6 5 Kelch motif Kelch_5 PF13854.1 KII61167.1 - 3.2e-15 55.6 14.8 0.00015 21.6 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KII61167.1 - 5.4e-07 29.1 11.9 0.053 13.3 0.0 5.7 6 0 0 6 6 6 3 Kelch motif Rax2 PF12768.2 KII61167.1 - 4.6e-05 22.7 1.4 0.00011 21.5 0.5 1.9 2 0 0 2 2 2 1 Cortical protein marker for cell polarity Kelch_6 PF13964.1 KII61168.1 - 3.5e-06 26.9 0.5 0.1 12.8 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII61168.1 - 0.00068 19.3 3.6 0.031 14.0 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII61168.1 - 0.0017 17.8 0.9 0.43 10.1 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.1 KII61168.1 - 0.013 15.4 4.7 0.07 13.1 1.3 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.1 KII61168.1 - 0.025 14.7 0.1 0.12 12.6 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF815 PF05673.8 KII61168.1 - 0.12 11.2 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Kelch_6 PF13964.1 KII61169.1 - 1.6e-13 50.2 5.0 0.0002 21.4 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII61169.1 - 1e-10 41.2 1.8 0.0009 19.1 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII61169.1 - 3.6e-10 39.4 6.7 0.00091 18.9 0.1 3.3 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII61169.1 - 3.5e-09 36.5 1.9 0.02 15.0 0.0 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII61169.1 - 5.1e-08 32.3 10.0 0.0046 16.4 0.6 3.5 3 1 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII61169.1 - 6.6e-07 28.8 1.9 0.29 10.9 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Asp_protease_2 PF13650.1 KII61172.1 - 0.014 15.9 0.0 0.023 15.2 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII61172.1 - 0.075 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Miro PF08477.8 KII61173.1 - 0.0076 16.7 0.0 0.015 15.7 0.0 1.5 1 1 0 1 1 1 1 Miro-like protein AlgF PF11182.3 KII61175.1 - 0.044 13.4 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Alginate O-acetyl transferase AlgF EBA-175_VI PF11556.3 KII61176.1 - 0.11 12.6 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Erythrocyte binding antigen 175 FAM150 PF15129.1 KII61177.1 - 0.002 18.0 0.1 0.0035 17.1 0.1 1.4 1 0 0 1 1 1 1 FAM150 family DDE_Tnp_IS1595 PF12762.2 KII61178.1 - 6.9e-18 64.9 0.8 1.2e-17 64.1 0.1 1.8 2 1 0 2 2 2 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII61178.1 - 0.0097 15.1 0.2 0.017 14.3 0.0 1.4 2 0 0 2 2 2 1 Transposase IS66 family Ldl_recept_a PF00057.13 KII61180.1 - 9e-34 115.0 137.7 1.6e-08 34.2 7.3 8.5 6 1 1 8 8 8 7 Low-density lipoprotein receptor domain class A RVT_1 PF00078.22 KII61181.1 - 3.9e-12 46.0 0.0 6.5e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII61181.1 - 0.0049 16.7 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease MULE PF10551.4 KII61182.1 - 0.00025 21.1 0.2 0.00052 20.1 0.2 1.6 1 0 0 1 1 1 1 MULE transposase domain rve PF00665.21 KII61185.1 - 2.9e-06 27.3 0.0 5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII61185.1 - 0.00031 20.1 0.0 0.0007 19.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RNHCP PF12647.2 KII61189.1 - 0.053 13.3 1.6 0.083 12.7 1.1 1.3 1 0 0 1 1 1 0 RNHCP domain HTH_Tnp_Tc5 PF03221.11 KII61190.1 - 1.4e-09 37.6 0.0 4.3e-09 36.0 0.0 1.9 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 KII61190.1 - 5.5e-07 28.9 1.2 1e-06 28.0 0.5 1.7 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.1 KII61190.1 - 0.00081 19.3 0.1 0.0018 18.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 KII61190.1 - 0.0069 16.0 0.1 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_1 PF01527.15 KII61190.1 - 0.012 15.5 0.5 0.024 14.6 0.4 1.8 1 1 0 1 1 1 0 Transposase DUF336 PF03928.9 KII61190.1 - 0.017 14.9 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF336) HTH_38 PF13936.1 KII61190.1 - 0.036 13.6 0.3 0.06 12.9 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Kelch_6 PF13964.1 KII61191.1 - 9.8e-24 82.4 23.5 4.8e-06 26.5 0.2 6.2 4 2 2 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII61191.1 - 1.3e-20 72.9 22.3 0.0002 21.0 0.1 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KII61191.1 - 1.1e-19 70.0 13.8 0.0069 16.5 0.0 6.6 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII61191.1 - 1.7e-13 49.9 20.5 1.2e-05 24.7 0.1 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KII61191.1 - 7.4e-12 44.5 11.9 0.00089 18.9 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 KII61191.1 - 8e-11 41.6 11.1 0.0089 15.9 0.1 5.2 5 0 0 5 5 5 3 Kelch motif Rax2 PF12768.2 KII61191.1 - 0.0023 17.2 0.1 0.013 14.7 0.1 2.0 1 1 1 2 2 2 1 Cortical protein marker for cell polarity Pox_D3 PF04580.8 KII61197.1 - 0.0068 15.6 0.0 0.0074 15.5 0.0 1.1 1 0 0 1 1 1 1 Chordopoxvirinae D3 protein rve PF00665.21 KII61198.1 - 3.4e-15 56.1 0.0 4.4e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII61198.1 - 0.0095 15.4 0.0 0.022 14.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve PF00665.21 KII61201.1 - 1.3e-09 38.1 0.0 1.5e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve PF00665.21 KII61202.1 - 2.8e-25 88.7 0.0 8.7e-25 87.1 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII61202.1 - 2.2e-18 66.4 0.0 2e-17 63.2 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII61202.1 - 2.3e-06 26.9 0.1 7.1e-06 25.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RICH PF05062.7 KII61202.1 - 0.15 12.2 3.7 0.6 10.2 1.0 2.6 2 0 0 2 2 2 0 RICH domain DDE_3 PF13358.1 KII61204.1 - 4.9e-12 45.8 0.1 6.3e-12 45.4 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 KII61205.1 - 3.1e-10 39.3 0.5 2.4e-08 33.3 0.0 2.8 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.1 KII61205.1 - 3.5e-10 39.6 1.4 1.5e-09 37.6 0.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII61205.1 - 1.2e-08 35.1 0.1 1.8e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII61205.1 - 1.5e-05 25.7 0.0 3.7e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.1 KII61205.1 - 1.9e-05 23.9 0.1 3.5e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding PAX PF00292.13 KII61205.1 - 3.3e-05 23.5 0.2 5.1e-05 22.9 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.11 KII61205.1 - 0.00013 21.6 1.0 0.00019 21.0 0.7 1.2 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.1 KII61205.1 - 0.00022 20.6 0.0 0.00044 19.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_11 PF08279.7 KII61205.1 - 0.00036 20.1 0.4 0.092 12.4 0.2 2.3 2 0 0 2 2 2 1 HTH domain HTH_Tnp_1 PF01527.15 KII61205.1 - 0.0005 19.9 0.1 0.016 15.1 0.0 2.2 1 1 1 2 2 2 1 Transposase DDE_3 PF13358.1 KII61205.1 - 0.00053 19.7 0.0 0.0013 18.5 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease TrmB PF01978.14 KII61205.1 - 0.0011 18.6 0.3 0.0028 17.3 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB CENP-B_N PF04218.8 KII61205.1 - 0.0011 18.2 1.4 0.0025 17.1 0.5 1.9 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_ISL3 PF13542.1 KII61205.1 - 0.0017 17.4 1.3 0.2 10.8 0.0 3.2 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 HTH_3 PF01381.17 KII61205.1 - 0.0044 16.8 0.1 0.0094 15.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix Sigma70_r4_2 PF08281.7 KII61205.1 - 0.0064 15.9 0.0 0.018 14.4 0.0 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.11 KII61205.1 - 0.013 14.7 0.1 0.027 13.7 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_38 PF13936.1 KII61205.1 - 0.014 14.9 0.7 0.12 11.9 0.8 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain MarR_2 PF12802.2 KII61205.1 - 0.025 14.2 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 MarR family DUF603 PF04645.7 KII61205.1 - 0.038 13.9 0.1 0.058 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF603 HTH_Tnp_Tc3_2 PF01498.13 KII61205.1 - 0.044 13.8 0.6 0.078 13.0 0.1 1.7 2 0 0 2 2 1 0 Transposase Bot1p PF12298.3 KII61205.1 - 0.056 13.3 1.1 1.4 8.8 0.1 2.2 2 0 0 2 2 2 0 Eukaryotic mitochondrial regulator protein HTH_1 PF00126.22 KII61205.1 - 0.065 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_8 PF02954.14 KII61205.1 - 0.1 12.1 0.2 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_17 PF12728.2 KII61205.1 - 0.11 12.8 0.2 1 9.6 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_36 PF13730.1 KII61205.1 - 0.12 12.4 0.1 0.36 10.9 0.0 1.8 2 0 0 2 2 1 0 Helix-turn-helix domain DUF977 PF06163.6 KII61205.1 - 0.14 11.9 0.9 0.39 10.4 0.5 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF977) PFEMP PF03011.10 KII61205.1 - 0.2 12.0 1.0 0.43 10.9 0.1 1.8 1 1 0 2 2 2 0 PFEMP DBL domain HTH_16 PF12645.2 KII61205.1 - 0.23 11.4 1.1 0.92 9.4 0.0 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain RVT_1 PF00078.22 KII61207.1 - 0.038 13.3 0.1 0.073 12.4 0.0 1.5 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotrans_gag PF03732.12 KII61209.1 - 0.0043 17.0 0.2 0.0066 16.4 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein HTH_29 PF13551.1 KII61210.1 - 0.00025 21.1 0.0 0.00031 20.8 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.1 KII61210.1 - 0.025 13.7 0.5 0.37 10.0 0.1 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 TrmB PF01978.14 KII61210.1 - 0.058 13.1 0.0 0.39 10.4 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 KII61210.1 - 0.11 11.8 0.1 0.4 10.1 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF4026 PF13218.1 KII61212.1 - 0.054 12.3 0.1 0.072 11.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4026) DDE_Tnp_IS1595 PF12762.2 KII61214.1 - 5.6e-08 32.7 0.0 7e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain HTH_5 PF01022.15 KII61215.1 - 0.0059 16.2 0.3 0.15 11.7 0.0 2.4 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family GerE PF00196.14 KII61215.1 - 0.027 13.8 0.1 0.34 10.2 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_23 PF13384.1 KII61215.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain INT_SG_DDX_CT_C PF15300.1 KII61215.1 - 0.19 11.1 2.7 3.5 7.1 0.2 2.9 3 0 0 3 3 3 0 INTS6/SAGE1/DDX26B/CT45 C-terminus SH2 PF00017.19 KII61216.1 - 2.1e-05 24.2 0.2 3.6e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 SH2 domain Kunitz_BPTI PF00014.18 KII61221.1 - 0.2 11.8 8.1 0.81 9.9 0.2 2.4 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain 2C_adapt PF08793.5 KII61221.1 - 0.36 10.7 2.3 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 2-cysteine adaptor domain RVP PF00077.15 KII61222.1 - 7.6e-06 25.7 0.0 1.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII61222.1 - 0.091 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Telomerase_RBD PF12009.3 KII61228.1 - 0.0031 17.4 0.7 0.0039 17.0 0.5 1.3 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain DDE_3 PF13358.1 KII61229.1 - 2.3e-36 124.7 0.0 2.7e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII61229.1 - 2.5e-07 30.7 0.0 3.5e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_1 PF03184.14 KII61229.1 - 2.6e-06 26.7 0.1 3.7e-06 26.2 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 KII61229.1 - 0.099 11.3 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DDE_3 PF13358.1 KII61230.1 - 9.6e-07 28.6 0.0 1.2e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Flocculin_t3 PF13928.1 KII61230.1 - 0.1 12.7 0.7 0.24 11.5 0.5 1.6 1 0 0 1 1 1 0 Flocculin type 3 repeat Kunitz_BPTI PF00014.18 KII61232.1 - 6.1e-05 23.1 15.1 7.9e-05 22.7 3.4 2.3 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF3826 PF12875.2 KII61232.1 - 0.011 15.4 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) Furin-like PF00757.15 KII61232.1 - 0.45 10.1 7.6 0.069 12.8 2.8 1.4 2 0 0 2 2 2 0 Furin-like cysteine rich region Fer4_10 PF13237.1 KII61232.1 - 5.4 6.8 7.1 0.88 9.4 0.8 2.2 2 1 0 2 2 2 0 4Fe-4S dicluster domain Apc4_WD40 PF12894.2 KII61233.1 - 1.6e-05 24.3 0.3 0.017 14.6 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain A2M_N_2 PF07703.9 KII61233.1 - 0.12 12.1 0.0 9.2 6.0 0.0 2.6 3 0 0 3 3 3 0 Alpha-2-macroglobulin family N-terminal region DUF3826 PF12875.2 KII61237.1 - 0.017 14.7 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) Kunitz_BPTI PF00014.18 KII61237.1 - 5.9 7.1 9.0 6.7 6.9 0.2 2.5 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain Kunitz_BPTI PF00014.18 KII61239.1 - 0.16 12.1 18.5 0.51 10.5 1.4 2.4 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain PurA PF04845.8 KII61240.1 - 0.0016 17.6 0.0 0.11 11.5 0.0 2.7 1 1 1 2 2 2 2 PurA ssDNA and RNA-binding protein zf-BED PF02892.10 KII61242.1 - 0.0008 19.1 1.6 0.0031 17.2 1.1 2.1 1 0 0 1 1 1 1 BED zinc finger RICTOR_phospho PF14665.1 KII61242.1 - 0.018 15.1 1.8 0.03 14.3 0.5 1.8 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, phosphorylation-site Voldacs PF03517.8 KII61242.1 - 0.051 13.4 0.1 0.06 13.1 0.1 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling zf-C2H2_jaz PF12171.3 KII61242.1 - 0.81 9.9 6.0 0.63 10.2 1.0 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_jaz PF12171.3 KII61243.1 - 0.1 12.7 0.8 0.1 12.7 0.5 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding MSG PF02349.10 KII61244.1 - 0.8 9.7 4.8 0.63 10.0 1.0 2.0 1 1 1 2 2 2 0 Major surface glycoprotein Usp PF00582.21 KII61246.1 - 0.0094 16.1 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Serpin PF00079.15 KII61247.1 - 1.4e-16 60.6 0.4 1.4e-16 60.6 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF877 PF05943.7 KII61247.1 - 0.062 11.7 0.0 0.072 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF877) Serpin PF00079.15 KII61248.1 - 5.3e-26 91.6 2.8 5.7e-26 91.5 1.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) ig PF00047.20 KII61249.1 - 0.1 12.7 0.3 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Serpin PF00079.15 KII61250.1 - 1.7e-13 50.5 3.0 1.9e-13 50.3 2.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII61251.1 - 1.1e-22 80.7 4.5 1.3e-22 80.4 3.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII61252.1 - 5.7e-05 22.4 0.3 6.1e-05 22.3 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_1 PF03184.14 KII61253.1 - 1.9e-32 112.1 0.0 2.4e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Aldedh PF00171.17 KII61254.1 - 4.3e-30 104.4 0.2 6.3e-30 103.9 0.1 1.3 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.17 KII61255.1 - 5.2e-30 104.1 0.0 5.7e-30 104.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.17 KII61256.1 - 9.3e-106 353.9 0.0 3.9e-52 177.1 0.1 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family PhageMin_Tail PF10145.4 KII61256.1 - 0.06 12.9 0.7 0.085 12.4 0.5 1.2 1 0 0 1 1 1 0 Phage-related minor tail protein Aldedh PF00171.17 KII61257.1 - 5.1e-27 94.3 0.0 5.6e-27 94.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Serpin PF00079.15 KII61258.1 - 2.6e-25 89.3 0.0 3.1e-25 89.0 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Phage_holin PF04688.8 KII61258.1 - 0.44 10.1 3.0 0.2 11.1 0.3 1.8 2 0 0 2 2 2 0 Phage lysis protein, holin Serpin PF00079.15 KII61260.1 - 9.5e-45 153.3 4.5 1.1e-44 153.1 3.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII61261.1 - 3.9e-44 151.2 4.4 4.7e-44 151.0 3.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII61262.1 - 1.9e-12 47.0 0.1 2.1e-12 46.8 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PET122 PF05476.6 KII61262.1 - 0.11 11.7 0.1 0.12 11.6 0.1 1.0 1 0 0 1 1 1 0 PET122 SNAP PF14938.1 KII61263.1 - 1.9e-06 27.2 0.4 2.3e-06 26.9 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RNase_Zc3h12a PF11977.3 KII61263.1 - 0.017 14.9 0.3 0.023 14.5 0.2 1.2 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain DUF3951 PF13131.1 KII61264.1 - 0.16 11.7 0.9 0.31 10.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) BRCT PF00533.21 KII61266.1 - 2e-06 27.8 1.1 4.7e-05 23.4 0.2 2.6 1 1 1 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KII61266.1 - 0.00015 21.5 0.3 0.00071 19.3 0.0 2.4 3 0 0 3 3 3 1 twin BRCT domain Peptidase_C1 PF00112.18 KII61270.1 - 2.7e-59 200.7 0.4 3.5e-59 200.3 0.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 KII61270.1 - 0.00068 18.2 1.1 0.17 10.3 0.0 2.8 3 1 1 4 4 4 2 Peptidase C1-like family GNT-I PF03071.10 KII61272.1 - 2.5e-78 263.5 3.2 3.1e-78 263.2 2.2 1.1 1 0 0 1 1 1 1 GNT-I family TCR PF03638.10 KII61274.1 - 4.6e-13 48.7 33.7 2e-11 43.5 13.7 2.4 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain YaaC PF14175.1 KII61274.1 - 0.029 13.3 0.2 0.041 12.8 0.1 1.1 1 0 0 1 1 1 0 YaaC-like Protein DDE_Tnp_IS1595 PF12762.2 KII61278.1 - 0.09 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 ISXO2-like transposase domain DUF4206 PF13901.1 KII61279.1 - 0.0023 17.4 3.6 0.0034 16.9 2.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4206) DUF3067 PF11267.3 KII61279.1 - 0.062 13.3 0.1 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3067) Bromodomain PF00439.20 KII61281.1 - 0.088 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Bromodomain DDE_Tnp_IS1595 PF12762.2 KII61283.1 - 1.5e-10 41.0 0.1 4e-10 39.7 0.1 1.6 1 1 1 2 2 2 1 ISXO2-like transposase domain RVT_1 PF00078.22 KII61288.1 - 1.4e-09 37.6 0.2 5.1e-06 26.0 0.0 3.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Xol-1_GHMP-like PF09109.5 KII61291.1 - 0.022 14.8 0.0 0.023 14.7 0.0 1.0 1 0 0 1 1 1 0 Switch protein XOL-1, GHMP-like RED_C PF07807.6 KII61293.1 - 0.0083 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 RED-like protein C-terminal region ClpS PF02617.12 KII61294.1 - 0.0075 15.9 0.1 0.013 15.2 0.1 1.3 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS rve PF00665.21 KII61295.1 - 6.6e-17 61.7 0.0 9.1e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII61295.1 - 4.9e-05 22.7 0.0 8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve PF00665.21 KII61298.1 - 2.3e-16 59.9 0.0 9.8e-16 57.9 0.0 1.9 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII61298.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Chaperone_III PF07824.7 KII61301.1 - 0.051 13.5 0.1 10 6.0 0.0 2.3 2 0 0 2 2 2 0 Type III secretion chaperone domain HobA PF12163.3 KII61301.1 - 0.081 12.2 0.2 2.4 7.3 0.0 2.1 1 1 0 2 2 2 0 DNA replication regulator DDE_3 PF13358.1 KII61303.1 - 7.6e-07 28.9 0.0 9.2e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RVT_1 PF00078.22 KII61305.1 - 0.0093 15.3 0.0 0.0095 15.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GATA PF00320.22 KII61306.1 - 1.4e-15 56.3 7.7 1.4e-15 56.3 5.4 2.5 2 0 0 2 2 2 1 GATA zinc finger DUF2387 PF09526.5 KII61306.1 - 0.00024 20.9 4.8 0.26 11.2 0.4 2.6 1 1 1 2 2 2 2 Probable metal-binding protein (DUF2387) zf-TFIIB PF13453.1 KII61306.1 - 0.0003 19.9 0.1 0.0003 19.9 0.1 2.1 2 0 0 2 2 2 1 Transcription factor zinc-finger TF_Zn_Ribbon PF08271.7 KII61306.1 - 0.00039 19.6 8.7 0.0066 15.7 1.0 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding eIF-5_eIF-2B PF01873.12 KII61306.1 - 0.0014 18.2 6.4 0.49 10.0 0.1 2.7 2 1 0 2 2 2 2 Domain found in IF2B/IF5 ArfGap PF01412.13 KII61306.1 - 0.013 15.2 0.6 0.013 15.2 0.4 2.6 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf DZR PF12773.2 KII61306.1 - 0.076 12.8 11.2 74 3.2 7.9 2.6 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.5 KII61306.1 - 0.16 11.9 0.1 0.16 11.9 0.1 3.2 2 1 3 5 5 5 0 Zinc ribbon domain OrfB_Zn_ribbon PF07282.6 KII61306.1 - 0.85 9.3 8.5 5.8 6.6 0.1 2.7 1 1 0 2 2 2 0 Putative transposase DNA-binding domain RRN7 PF11781.3 KII61306.1 - 0.89 9.1 7.9 0.24 10.9 0.5 3.0 2 1 1 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 Zn_Tnp_IS1595 PF12760.2 KII61306.1 - 0.94 9.3 7.9 9.1 6.1 1.8 3.2 2 2 1 3 3 3 0 Transposase zinc-ribbon domain NOB1_Zn_bind PF08772.6 KII61306.1 - 1.4 8.7 12.8 1.6 8.6 1.2 2.5 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Prim_Zn_Ribbon PF08273.7 KII61306.1 - 8.4 6.5 13.0 11 6.1 0.2 4.1 3 1 1 4 4 4 0 Zinc-binding domain of primase-helicase DUF2248 PF10005.4 KII61307.1 - 0.044 12.7 0.1 0.053 12.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2248) Pico_P1A PF02226.11 KII61308.1 - 0.042 13.5 4.5 1.7 8.4 0.1 2.3 2 0 0 2 2 2 0 Picornavirus coat protein (VP4) DUF4184 PF13803.1 KII61308.1 - 0.05 12.9 0.2 0.074 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4184) Porin_3 PF01459.17 KII61309.1 - 3e-09 36.5 0.0 7.9e-09 35.2 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic porin ATG11 PF10377.4 KII61310.1 - 3e-06 27.1 0.3 3.3e-06 27.0 0.2 1.1 1 0 0 1 1 1 1 Autophagy-related protein 11 DUF3737 PF12541.3 KII61310.1 - 0.0053 15.7 0.1 0.0076 15.2 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3737) MCC-bdg_PDZ PF10506.4 KII61310.1 - 0.022 14.5 0.2 0.033 14.0 0.1 1.2 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF3896 PF13035.1 KII61310.1 - 3 7.9 6.5 0.34 11.0 1.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) Erf4 PF10256.4 KII61311.1 - 1.5e-24 86.1 1.2 1.9e-24 85.8 0.8 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Rib_5-P_isom_A PF06026.9 KII61312.1 - 1.8e-53 180.4 0.2 2.3e-53 180.0 0.1 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Tetraspannin PF00335.15 KII61313.1 - 0.78 8.9 5.2 6.5 5.9 3.4 2.0 1 1 1 2 2 2 0 Tetraspanin family UPF0020 PF01170.13 KII61314.1 - 4e-13 49.3 0.0 7.6e-13 48.4 0.0 1.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 KII61314.1 - 2.3e-07 30.8 0.0 3.3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 KII61314.1 - 0.00069 19.1 0.0 0.057 12.9 0.0 2.2 2 0 0 2 2 2 1 DNA methylase Methyltransf_15 PF09445.5 KII61314.1 - 0.0083 15.6 0.2 0.054 13.0 0.2 1.9 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.10 KII61314.1 - 0.08 12.3 0.1 2.6 7.4 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical protein 95 N6_Mtase PF02384.11 KII61314.1 - 0.081 11.9 0.0 0.33 9.9 0.0 1.8 1 1 0 1 1 1 0 N-6 DNA Methylase MethyltransfD12 PF02086.10 KII61314.1 - 0.082 12.3 0.3 1.3 8.3 0.0 2.0 1 1 1 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase WD40 PF00400.27 KII61315.1 - 1.2e-25 88.3 21.7 4.4e-07 29.5 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat DUF972 PF06156.8 KII61315.1 - 0.0037 17.5 0.7 0.0079 16.5 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF972) Shugoshin_N PF07558.6 KII61315.1 - 0.004 16.8 0.2 0.0096 15.6 0.2 1.7 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Herpes_BLRF2 PF05812.7 KII61315.1 - 0.02 14.7 0.1 0.034 13.9 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein FH2 PF02181.18 KII61315.1 - 0.02 13.7 1.6 0.031 13.1 1.1 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain DivIC PF04977.10 KII61315.1 - 0.059 12.8 0.8 0.1 12.0 0.1 1.7 2 0 0 2 2 2 0 Septum formation initiator DUF4165 PF13752.1 KII61315.1 - 0.064 13.0 0.0 0.27 11.0 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4165) Lipocalin PF00061.18 KII61316.1 - 0.0041 17.1 0.5 0.0056 16.6 0.4 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Gp_UL130 PF11668.3 KII61316.1 - 0.058 12.9 0.2 0.081 12.4 0.2 1.2 1 0 0 1 1 1 0 HCMV glycoprotein pUL130 DUF951 PF06107.6 KII61317.1 - 0.026 14.0 0.4 0.053 13.0 0.3 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF951) DUF4296 PF14129.1 KII61317.1 - 0.12 12.5 0.1 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) zinc_ribbon_5 PF13719.1 KII61317.1 - 0.18 11.4 1.1 0.87 9.2 0.2 2.5 3 0 0 3 3 3 0 zinc-ribbon domain DUF4182 PF13790.1 KII61317.1 - 0.69 9.7 2.4 14 5.6 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4182) GAS2 PF02187.12 KII61318.1 - 0.016 14.9 0.0 0.04 13.6 0.0 1.6 1 0 0 1 1 1 0 Growth-Arrest-Specific Protein 2 Domain SMK-1 PF04802.10 KII61318.1 - 0.074 12.5 0.4 0.12 11.9 0.3 1.2 1 0 0 1 1 1 0 Component of IIS longevity pathway SMK-1 DUF1899 PF08953.6 KII61318.1 - 0.11 12.1 0.1 9.2 6.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1899) CH PF00307.26 KII61319.1 - 5.5e-08 32.8 0.3 1.4e-07 31.4 0.2 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF4179 PF13786.1 KII61319.1 - 0.12 12.6 1.2 0.38 11.0 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) Herpes_UL4 PF03277.8 KII61319.1 - 0.19 10.9 2.0 0.17 11.1 0.1 1.8 2 1 0 2 2 2 0 Herpesvirus UL4 family DDE_Tnp_IS1595 PF12762.2 KII61320.1 - 1.1e-06 28.6 0.0 7.6e-06 25.8 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain NUFIP1 PF10453.4 KII61321.1 - 2.3e-07 30.1 6.4 2.3e-07 30.1 4.5 1.9 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) G10 PF01125.12 KII61321.1 - 2.2 7.8 8.2 5.1 6.6 5.7 1.7 1 1 0 1 1 1 0 G10 protein Peptidase_M3 PF01432.15 KII61322.1 - 5.3e-128 427.9 1.5 6.9e-128 427.5 1.1 1.1 1 0 0 1 1 1 1 Peptidase family M3 PP2C PF00481.16 KII61323.1 - 7.3e-08 32.1 0.0 0.00028 20.3 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 KII61323.1 - 0.0076 15.6 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C Ldl_recept_a PF00057.13 KII61327.1 - 1.1e-07 31.6 11.8 1.1e-07 31.6 8.2 3.0 3 1 0 3 3 3 2 Low-density lipoprotein receptor domain class A tRNA-synt_1g PF09334.6 KII61328.1 - 7.3e-31 107.1 0.3 1.1e-30 106.6 0.2 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) Anticodon_1 PF08264.8 KII61328.1 - 0.0057 16.4 0.0 0.0087 15.8 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KII61329.1 - 5.8e-67 226.0 0.7 6.7e-67 225.8 0.5 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 KII61329.1 - 4.6e-06 24.9 0.0 8.5e-06 24.0 0.0 1.3 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Mu-like_Com PF10122.4 KII61329.1 - 0.0031 16.5 2.9 0.63 9.1 0.7 2.6 2 0 0 2 2 2 2 Mu-like prophage protein Com DUF1228 PF06779.9 KII61329.1 - 0.098 12.6 0.1 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1228) DUF2797 PF10977.3 KII61329.1 - 0.55 9.8 2.8 0.89 9.1 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Rpr2 PF04032.11 KII61329.1 - 1.7 8.6 7.0 0.41 10.5 0.6 2.7 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain C1_1 PF00130.17 KII61329.1 - 4.3 7.1 16.0 1.4 8.7 0.6 3.0 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HTH_Tnp_Tc5 PF03221.11 KII61330.1 - 4.1e-05 23.3 2.2 0.0017 18.1 1.5 2.5 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain AAA_11 PF13086.1 KII61330.1 - 0.014 14.9 0.1 0.017 14.7 0.1 1.1 1 0 0 1 1 1 0 AAA domain Glyco_transf_41 PF13844.1 KII61331.1 - 3.5e-152 506.6 0.2 1.5e-81 273.7 0.1 2.2 1 1 0 2 2 2 2 Glycosyl transferase family 41 TPR_11 PF13414.1 KII61331.1 - 2.8e-66 219.1 31.1 1.2e-13 50.5 0.2 8.9 7 2 2 9 9 9 8 TPR repeat TPR_1 PF00515.23 KII61331.1 - 9.3e-52 170.6 31.0 3.2e-07 29.6 0.1 13.6 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_2 PF07719.12 KII61331.1 - 8.8e-46 150.1 22.8 9.7e-06 25.1 0.0 13.3 13 0 0 13 13 13 10 Tetratricopeptide repeat TPR_12 PF13424.1 KII61331.1 - 9.1e-41 137.6 21.7 1.5e-10 40.8 0.4 8.2 4 1 4 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 KII61331.1 - 5.5e-39 132.0 1.0 1.6e-08 34.9 0.1 7.5 5 1 3 8 8 8 7 Tetratricopeptide repeat TPR_17 PF13431.1 KII61331.1 - 3e-38 126.8 21.3 4.8e-06 26.3 0.1 12.4 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_14 PF13428.1 KII61331.1 - 2.9e-34 114.3 0.0 7.2e-05 23.0 0.0 10.5 4 3 7 11 11 11 6 Tetratricopeptide repeat TPR_8 PF13181.1 KII61331.1 - 6.5e-34 113.1 13.9 0.0038 16.9 0.0 12.8 11 1 2 13 13 12 10 Tetratricopeptide repeat TPR_19 PF14559.1 KII61331.1 - 2.9e-28 97.9 1.8 1e-05 25.7 0.0 7.7 4 2 5 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.1 KII61331.1 - 4.4e-18 63.5 13.9 0.066 13.0 0.0 11.5 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_10 PF13374.1 KII61331.1 - 3.4e-14 52.2 5.2 5.6e-05 22.9 0.1 7.4 7 0 0 7 7 6 2 Tetratricopeptide repeat Apc3 PF12895.2 KII61331.1 - 6.4e-14 51.8 16.7 0.00063 19.8 0.0 5.7 3 2 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KII61331.1 - 4e-13 48.8 0.4 0.19 12.2 0.0 8.8 11 0 0 11 11 9 3 Tetratricopeptide repeat NARP1 PF12569.3 KII61331.1 - 1.2e-09 37.5 2.4 0.05 12.3 0.0 5.3 2 1 4 7 7 7 4 NMDA receptor-regulated protein 1 TPR_9 PF13371.1 KII61331.1 - 5.3e-09 35.8 1.1 0.24 11.2 0.1 5.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 KII61331.1 - 2.2e-05 23.6 1.6 0.12 11.3 0.8 4.5 2 1 3 5 5 5 2 Tetratricopeptide repeat Glyco_trans_1_4 PF13692.1 KII61331.1 - 0.0023 18.0 0.0 0.017 15.2 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 ChAPs PF09295.5 KII61331.1 - 0.0043 15.8 0.1 0.45 9.2 0.0 2.5 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.12 KII61331.1 - 0.057 13.7 0.1 21 5.3 0.0 3.3 2 1 0 3 3 3 0 Bacterial transcriptional activator domain TPR_3 PF07720.7 KII61331.1 - 0.067 13.0 5.6 3.4 7.5 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat MIT PF04212.13 KII61331.1 - 0.13 12.2 7.3 22 4.9 0.0 5.5 6 1 0 6 6 5 0 MIT (microtubule interacting and transport) domain SNAP PF14938.1 KII61331.1 - 0.18 10.8 8.0 2.5 7.1 0.2 4.0 1 1 2 3 3 3 0 Soluble NSF attachment protein, SNAP PPR PF01535.15 KII61331.1 - 0.25 11.3 4.9 11 6.2 0.0 4.8 5 0 0 5 5 5 0 PPR repeat Ribosomal_S2 PF00318.15 KII61332.1 - 1.1e-32 112.9 2.1 9.1e-17 60.9 0.1 2.4 2 1 0 2 2 2 2 Ribosomal protein S2 RPEL PF02755.10 KII61333.1 - 0.075 12.3 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 RPEL repeat Hydrolase_like2 PF13246.1 KII61335.1 - 3.2e-12 46.2 0.1 2e-11 43.6 0.0 2.2 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 KII61335.1 - 4.7e-11 43.2 0.0 1.1e-10 41.9 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KII61335.1 - 2.2e-09 38.0 0.0 2.3e-08 34.7 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 KII61335.1 - 0.00051 19.1 3.2 0.00051 19.1 2.2 2.4 2 1 0 2 2 2 1 E1-E2 ATPase DUF4231 PF14015.1 KII61335.1 - 8.8 6.3 6.8 39 4.2 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) HAD PF12710.2 KII61336.1 - 1.2e-14 54.9 0.5 3.9e-14 53.2 0.3 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KII61336.1 - 5.8e-12 46.4 0.0 1.8e-10 41.6 0.0 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII61336.1 - 1.6e-11 44.0 0.0 4.4e-11 42.5 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KII61336.1 - 0.0077 15.8 0.5 0.024 14.1 0.3 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CP2 PF04516.10 KII61339.1 - 8.2e-11 41.4 0.4 9.9e-11 41.1 0.3 1.1 1 0 0 1 1 1 1 CP2 transcription factor Imm20 PF15568.1 KII61339.1 - 0.11 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 20 Shigella_OspC PF06128.6 KII61341.1 - 0.09 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Shigella flexneri OspC protein ubiquitin PF00240.18 KII61345.1 - 3.3e-06 26.4 0.0 5.6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 KII61345.1 - 0.00073 19.1 0.0 0.02 14.5 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like RNA_pol_Rpb2_6 PF00562.23 KII61348.1 - 4e-27 94.9 0.0 4.9e-27 94.6 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.15 KII61348.1 - 8.1e-08 32.4 2.1 2.1e-07 31.1 0.7 2.0 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.11 KII61349.1 - 1.6e-18 66.1 0.0 3e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.9 KII61349.1 - 9e-05 21.9 1.1 0.00015 21.2 0.0 1.9 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_1 PF04563.10 KII61349.1 - 0.11 11.3 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase beta subunit RNA_pol_Rpb2_1 PF04563.10 KII61350.1 - 1.8e-28 98.8 1.0 2e-28 98.7 0.7 1.0 1 0 0 1 1 1 1 RNA polymerase beta subunit DDE_3 PF13358.1 KII61351.1 - 2.4e-11 43.6 0.0 2.8e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII61351.1 - 0.011 14.9 0.1 0.017 14.2 0.1 1.3 1 1 0 1 1 1 0 DDE superfamily endonuclease CAMSAP_CKK PF08683.6 KII61351.1 - 0.041 13.5 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated Globin PF00042.17 KII61355.1 - 1.7e-09 37.9 0.0 2.4e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Globin DUF677 PF05055.7 KII61355.1 - 0.079 11.6 0.6 0.11 11.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) EMP24_GP25L PF01105.19 KII61355.1 - 0.094 12.4 0.6 0.14 11.8 0.4 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD PAP_central PF04928.12 KII61356.1 - 2.2e-79 265.8 0.0 3e-79 265.4 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 KII61356.1 - 1.7e-20 73.0 0.7 3.3e-20 72.1 0.5 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 KII61356.1 - 9.4e-05 22.6 0.0 0.00025 21.3 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain RNA_pol_Rpc34 PF05158.7 KII61358.1 - 9.8e-35 120.2 0.5 1.2e-34 120.0 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit TrmB PF01978.14 KII61358.1 - 3.5e-07 29.8 1.1 0.079 12.6 0.0 3.7 3 1 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB RPA_C PF08784.6 KII61358.1 - 0.00035 20.9 0.4 0.92 9.9 0.0 2.8 3 0 0 3 3 3 2 Replication protein A C terminal HTH_24 PF13412.1 KII61358.1 - 0.0022 17.3 7.6 0.0028 17.0 0.6 3.8 4 0 0 4 4 4 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.15 KII61358.1 - 0.017 15.2 0.1 1.4 9.0 0.0 3.1 4 0 0 4 4 4 0 Transcriptional regulator MarR PF01047.17 KII61358.1 - 0.017 14.8 0.1 0.41 10.4 0.0 2.5 2 0 0 2 2 2 0 MarR family Penicillinase_R PF03965.11 KII61358.1 - 0.11 12.5 0.0 6.2 6.9 0.0 2.9 3 0 0 3 3 3 0 Penicillinase repressor Tubulin PF00091.20 KII61360.1 - 1.6e-54 185.0 0.0 2.8e-54 184.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KII61360.1 - 1.6e-46 157.4 0.0 2.6e-46 156.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Lipase_3 PF01764.20 KII61360.1 - 0.00015 21.3 0.4 0.00091 18.8 0.0 2.3 3 0 0 3 3 3 1 Lipase (class 3) Tubulin_2 PF13809.1 KII61360.1 - 0.1 11.4 0.0 0.24 10.2 0.0 1.5 2 0 0 2 2 2 0 Tubulin like T2SE PF00437.15 KII61360.1 - 0.12 11.2 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF479 PF04336.7 KII61363.1 - 0.12 12.5 1.5 0.44 10.6 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function, DUF479 zf-C2H2 PF00096.21 KII61364.1 - 0.02 15.2 0.2 0.02 15.2 0.2 3.5 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-met2 PF12907.2 KII61364.1 - 0.11 12.4 3.5 2.9 7.9 0.6 2.5 1 1 1 2 2 2 0 Zinc-binding zf-C2H2_4 PF13894.1 KII61364.1 - 0.15 12.4 0.3 0.15 12.4 0.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.7 KII61364.1 - 0.18 11.9 4.9 0.13 12.3 2.1 1.7 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF4428 PF14471.1 KII61364.1 - 0.71 9.6 3.4 3.2 7.5 2.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) zf-H2C2_2 PF13465.1 KII61364.1 - 1.3 9.4 12.8 1.9 8.9 0.2 3.1 3 0 0 3 3 3 0 Zinc-finger double domain zf-met PF12874.2 KII61364.1 - 5.3 7.3 7.8 12 6.3 0.1 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF2975 PF11188.3 KII61365.1 - 0.045 13.4 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) DUF1184 PF06683.6 KII61365.1 - 0.056 13.0 0.2 0.073 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1184) Baculo_11_kDa PF06143.6 KII61365.1 - 0.42 10.0 6.1 0.23 10.8 2.6 1.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family RNase_T PF00929.19 KII61366.1 - 1.1e-11 45.2 0.1 1.6e-11 44.7 0.1 1.2 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 KII61366.1 - 0.00064 19.2 0.0 0.00086 18.8 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease RNase_T PF00929.19 KII61367.1 - 1.4e-12 48.2 0.2 1.9e-12 47.8 0.1 1.2 1 0 0 1 1 1 1 Exonuclease DUF4524 PF15025.1 KII61367.1 - 0.046 13.1 0.1 0.086 12.3 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4524) ABC_tran PF00005.22 KII61368.1 - 4e-11 43.3 0.2 6.1e-11 42.7 0.2 1.3 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 KII61368.1 - 0.0065 16.6 0.1 0.16 12.1 0.1 2.0 1 1 1 2 2 2 1 AAA domain DUF87 PF01935.12 KII61368.1 - 0.0092 15.8 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF87 AAA_21 PF13304.1 KII61368.1 - 0.013 15.4 3.5 0.04 13.8 0.1 2.0 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 KII61368.1 - 0.014 15.8 0.1 0.024 15.1 0.1 1.4 1 0 0 1 1 1 0 Miro-like protein Gtr1_RagA PF04670.7 KII61368.1 - 0.022 13.8 0.1 0.032 13.3 0.1 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region UPF0079 PF02367.12 KII61368.1 - 0.052 13.1 0.1 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_17 PF13207.1 KII61368.1 - 0.075 13.8 0.1 0.13 13.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 KII61368.1 - 0.076 11.8 0.0 0.094 11.6 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein PRK PF00485.13 KII61368.1 - 0.096 12.2 0.3 0.24 10.9 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.1 KII61368.1 - 0.16 11.4 0.5 0.29 10.6 0.1 1.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.22 KII61369.1 - 3.1e-08 34.0 0.0 4e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KII61369.1 - 1.8e-07 30.6 0.1 2e-07 30.4 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 KII61369.1 - 0.085 12.7 0.0 0.28 11.1 0.0 1.9 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ArfGap PF01412.13 KII61370.1 - 2e-14 53.4 1.6 9.9e-14 51.1 0.4 2.5 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ank_5 PF13857.1 KII61370.1 - 8.2e-05 22.7 0.1 0.0002 21.4 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) GIT_SHD PF08518.6 KII61370.1 - 0.0002 20.6 0.1 0.0023 17.2 0.1 2.6 2 0 0 2 2 2 1 Spa2 homology domain (SHD) of GIT Ank_3 PF13606.1 KII61370.1 - 0.0018 18.3 0.2 1.5 9.2 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KII61370.1 - 0.0018 18.7 0.1 0.016 15.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KII61370.1 - 0.0026 18.0 0.5 0.013 15.8 0.2 2.2 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Helicase_C PF00271.26 KII61371.1 - 6.9e-07 29.0 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 KII61371.1 - 0.00037 19.3 0.0 0.00037 19.3 0.0 1.0 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 AIF_C PF14721.1 KII61372.1 - 3.6e-07 30.4 0.2 0.00011 22.4 0.1 2.8 3 1 1 4 4 4 2 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox_2 PF07992.9 KII61372.1 - 1e-05 25.4 0.0 1.7e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KII61372.1 - 0.026 14.9 0.0 1.6 9.1 0.0 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF1344 PF07076.6 KII61372.1 - 0.051 13.1 0.3 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) Pox_P35 PF03213.9 KII61374.1 - 0.06 12.3 0.1 0.81 8.6 0.3 2.0 1 1 1 2 2 2 0 Poxvirus P35 protein C1_1 PF00130.17 KII61375.1 - 1.2e-09 37.7 4.8 2.2e-09 36.9 3.3 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RA PF00788.18 KII61375.1 - 1.9e-09 37.8 0.1 5e-09 36.5 0.0 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Ion_trans PF00520.26 KII61376.1 - 1.8e-41 141.6 83.8 2.7e-22 79.0 14.6 3.5 3 0 0 3 3 3 3 Ion transport protein hEGF PF12661.2 KII61378.1 - 0.0014 18.6 3.3 0.0014 18.6 2.3 3.3 3 0 0 3 3 3 1 Human growth factor-like EGF Toxin_31 PF08119.6 KII61378.1 - 0.23 11.0 9.6 0.83 9.2 6.6 2.0 1 1 0 1 1 1 0 Scorpion acidic alpha-KTx toxin family Toxin_11 PF07473.6 KII61378.1 - 6 6.8 8.9 0.62 9.9 1.3 2.8 2 2 0 2 2 2 0 Spasmodic peptide gm9a DUF3953 PF13129.1 KII61379.1 - 0.013 15.0 0.5 0.029 13.9 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) DUF485 PF04341.7 KII61379.1 - 0.1 12.3 0.1 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF485 DUF872 PF05915.7 KII61379.1 - 0.11 12.3 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) EGF_2 PF07974.8 KII61380.1 - 0.017 15.2 23.3 0.058 13.5 0.5 3.3 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.2 KII61380.1 - 0.02 14.9 2.4 0.02 14.9 1.7 3.7 3 0 0 3 3 3 0 Human growth factor-like EGF Phage_FRD3 PF05798.6 KII61380.1 - 0.12 12.7 0.1 0.12 12.7 0.1 2.1 2 1 0 2 2 2 0 Bacteriophage FRD3 protein Tme5_EGF_like PF09064.5 KII61380.1 - 2.4 7.8 24.0 1.3 8.7 0.1 3.4 3 0 0 3 3 3 0 Thrombomodulin like fifth domain, EGF-like EGF PF00008.22 KII61381.1 - 0.017 15.0 9.9 0.017 15.0 6.9 4.2 3 2 0 3 3 3 0 EGF-like domain hEGF PF12661.2 KII61381.1 - 4.3 7.6 11.9 22 5.3 4.8 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF Helicase_C PF00271.26 KII61382.1 - 7.7e-15 54.5 0.0 1.4e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-P11 PF03854.9 KII61382.1 - 0.022 14.2 1.2 0.047 13.1 0.9 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-C3HC4_3 PF13920.1 KII61382.1 - 0.027 14.1 1.8 0.056 13.1 1.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.24 KII61383.1 - 0.0031 17.0 0.0 0.0031 17.0 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase PGI PF00342.14 KII61386.1 - 1.9e-50 171.7 0.1 2.2e-50 171.4 0.1 1.1 1 0 0 1 1 1 1 Phosphoglucose isomerase V-SNARE_C PF12352.3 KII61388.1 - 8.3e-10 38.5 2.4 4.9e-07 29.7 0.8 3.0 3 1 0 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus DUF2353 PF09789.4 KII61388.1 - 0.0014 17.9 6.6 0.0016 17.7 4.6 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) SF-assemblin PF06705.6 KII61388.1 - 0.0042 16.2 4.4 0.0064 15.6 2.7 1.6 1 1 1 2 2 2 1 SF-assemblin/beta giardin DUF3731 PF12531.3 KII61388.1 - 0.06 12.8 0.5 0.085 12.3 0.3 1.4 1 1 0 1 1 1 0 DNA-K related protein Toxin-deaminase PF14424.1 KII61388.1 - 0.071 13.0 0.4 0.12 12.3 0.3 1.3 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases DDE_3 PF13358.1 KII61390.1 - 4.1e-15 55.7 0.0 5.2e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII61390.1 - 0.12 12.4 0.0 0.43 10.7 0.0 1.7 2 0 0 2 2 2 0 Integrase core domain SNARE_assoc PF09335.6 KII61390.1 - 0.14 12.4 0.5 0.45 10.7 0.2 1.9 1 1 1 2 2 2 0 SNARE associated Golgi protein EZH2_WD-Binding PF11616.3 KII61391.1 - 0.043 13.6 0.4 0.082 12.7 0.3 1.5 1 0 0 1 1 1 0 WD repeat binding protein EZH2 Antimicrobial19 PF08225.6 KII61391.1 - 4.1 6.8 5.5 0.63 9.5 0.3 2.3 2 0 0 2 2 2 0 Pseudin antimicrobial peptide MtN3_slv PF03083.11 KII61392.1 - 7.2 6.5 9.7 0.4 10.5 1.0 2.9 2 1 1 4 4 4 0 Sugar efflux transporter for intercellular exchange Sugar_tr PF00083.19 KII61393.1 - 2.4e-46 158.2 33.7 2.9e-46 157.9 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII61393.1 - 1.3e-06 27.3 35.0 1.3e-06 27.3 24.2 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Aph-1 PF06105.7 KII61394.1 - 0.56 9.4 7.2 0.057 12.6 1.0 1.8 2 0 0 2 2 2 0 Aph-1 protein Adeno_E3B PF03376.9 KII61394.1 - 1.9 8.4 5.7 0.28 11.0 0.3 2.2 2 1 0 2 2 2 0 Adenovirus E3B protein SH PF01445.12 KII61394.1 - 3.9 7.1 8.5 9.1 6.0 1.1 2.5 2 0 0 2 2 2 0 Viral small hydrophobic protein Fer4 PF00037.22 KII61395.1 - 5.1e-14 51.1 17.4 1.7e-08 33.7 3.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 KII61395.1 - 2.6e-12 46.8 10.9 4.5e-12 46.1 7.6 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.1 KII61395.1 - 5.6e-10 39.8 5.7 0.00014 22.5 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.1 KII61395.1 - 6.8e-10 39.0 9.0 1.4e-09 38.0 6.3 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 KII61395.1 - 1.7e-09 37.3 22.6 6.9e-08 32.1 8.8 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 KII61395.1 - 1.1e-08 34.4 13.9 9.1e-05 22.1 1.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.1 KII61395.1 - 4.1e-08 33.1 19.2 1.3e-05 25.1 8.1 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.2 KII61395.1 - 6.6e-08 32.0 18.0 0.00071 19.3 3.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.1 KII61395.1 - 7.8e-08 32.0 22.8 1.3e-05 24.9 8.7 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.2 KII61395.1 - 2.4e-06 27.4 12.2 0.00062 19.8 2.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 KII61395.1 - 1.8e-05 25.0 10.3 0.0005 20.3 7.8 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_18 PF13746.1 KII61395.1 - 3.6e-05 24.0 10.1 0.02 15.2 0.7 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.1 KII61395.1 - 0.00012 22.3 11.1 0.04 14.3 0.5 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_15 PF13459.1 KII61395.1 - 0.0066 16.9 12.8 0.35 11.4 1.3 2.6 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_3 PF12798.2 KII61395.1 - 0.037 14.5 18.1 0.076 13.6 3.2 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.5 KII61395.1 - 0.69 10.0 5.5 0.86 9.7 0.1 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain RCC1_2 PF13540.1 KII61396.1 - 9.3e-23 79.2 11.1 2.7e-08 33.1 0.2 3.5 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 KII61396.1 - 1.2e-16 60.6 5.4 7.2e-07 29.3 0.0 4.1 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat DEAD PF00270.24 KII61397.1 - 3.9e-22 78.5 0.0 6.7e-13 48.4 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KII61397.1 - 7.9e-06 25.6 0.0 1.8e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain EGF PF00008.22 KII61398.1 - 0.00017 21.4 48.5 0.00032 20.5 4.5 5.8 4 1 0 4 4 4 2 EGF-like domain EGF_2 PF07974.8 KII61398.1 - 0.0066 16.5 9.2 0.0066 16.5 6.4 5.3 6 0 0 6 6 6 3 EGF-like domain hEGF PF12661.2 KII61398.1 - 0.089 12.9 0.8 0.089 12.9 0.5 4.5 4 0 0 4 4 4 0 Human growth factor-like EGF GTP_EFTU PF00009.22 KII61399.1 - 8.6e-24 84.0 0.0 1.6e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 KII61399.1 - 3.5e-12 46.1 0.0 8.4e-12 44.9 0.0 1.6 1 0 0 1 1 1 1 Translation-initiation factor 2 PduV-EutP PF10662.4 KII61399.1 - 0.0021 17.5 0.2 0.0047 16.4 0.1 1.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU_D2 PF03144.20 KII61399.1 - 0.0022 18.0 0.0 0.016 15.3 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KII61399.1 - 0.01 15.8 0.2 0.038 13.9 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 KII61399.1 - 0.088 12.4 0.1 0.4 10.3 0.1 2.1 1 1 0 1 1 1 0 Elongation factor Tu domain 4 AMP-binding PF00501.23 KII61400.1 - 4.9e-22 77.9 0.0 7.8e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PQQ_3 PF13570.1 KII61400.1 - 2e-21 75.5 0.0 4.1e-07 30.0 0.0 8.1 8 0 0 8 8 8 4 PQQ-like domain PQQ_2 PF13360.1 KII61400.1 - 9.3e-19 67.8 0.0 7.8e-09 35.3 0.0 4.0 1 1 1 2 2 2 2 PQQ-like domain PQQ PF01011.16 KII61400.1 - 1.8e-18 65.0 0.2 1.6e-05 24.1 0.0 5.3 5 0 0 5 5 5 4 PQQ enzyme repeat PP-binding PF00550.20 KII61400.1 - 0.0066 16.6 0.1 0.018 15.2 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site PCI_Csn8 PF10075.4 KII61401.1 - 7.5e-17 61.4 0.6 1.2e-16 60.8 0.4 1.4 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 KII61401.1 - 5.1e-15 55.5 1.8 5.1e-15 55.5 1.2 1.5 2 0 0 2 2 2 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family Neur_chan_memb PF02932.11 KII61403.1 - 1.5 8.6 8.2 0.13 12.1 0.6 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Macoilin PF09726.4 KII61403.1 - 8.8 4.4 16.0 10 4.2 11.1 1.1 1 0 0 1 1 1 0 Transmembrane protein DDE_3 PF13358.1 KII61405.1 - 0.0001 22.1 0.0 0.00014 21.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Transglut_core PF01841.14 KII61406.1 - 0.0076 16.4 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Peptidase_M17 PF00883.16 KII61408.1 - 5.4e-114 380.2 0.1 6.6e-114 379.9 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.12 KII61408.1 - 2.6e-10 40.1 0.0 6.3e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain DUF4371 PF14291.1 KII61409.1 - 0.0055 16.2 0.1 0.0072 15.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Jiv90 PF14901.1 KII61413.1 - 0.067 13.1 0.0 4.9 7.2 0.0 2.5 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone MULE PF10551.4 KII61414.1 - 6.1e-06 26.3 0.1 1.3e-05 25.2 0.0 1.6 1 1 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.12 KII61414.1 - 0.068 12.7 0.0 0.13 11.8 0.0 1.5 1 1 1 2 2 2 0 Transposase DUF1955 PF09205.5 KII61414.1 - 0.092 12.2 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) AviRa PF11599.3 KII61414.1 - 0.15 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa SBDS PF01172.13 KII61416.1 - 1.6e-27 95.0 1.9 3.4e-27 94.0 1.3 1.6 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.5 KII61416.1 - 4.4e-16 58.7 1.5 8.8e-16 57.7 1.0 1.5 1 0 0 1 1 1 1 SBDS protein C-terminal domain DUF3416 PF11896.3 KII61416.1 - 0.12 12.2 0.1 0.6 10.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3416) Homeobox PF00046.24 KII61417.1 - 0.0039 16.7 0.0 0.011 15.2 0.0 1.7 2 0 0 2 2 2 1 Homeobox domain PRP21_like_P PF12230.3 KII61419.1 - 1.8e-36 125.8 16.8 6.5e-36 123.9 11.6 2.0 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.15 KII61419.1 - 5.6e-36 121.9 8.0 2.6e-18 65.4 1.2 2.6 2 0 0 2 2 2 2 Surp module ubiquitin PF00240.18 KII61419.1 - 4.2e-09 35.6 0.3 1.2e-08 34.1 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 KII61419.1 - 8.6e-05 22.7 0.4 0.00023 21.3 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain PUA PF01472.15 KII61420.1 - 3.2e-15 55.5 0.0 5.1e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 PUA domain Ribosomal_S16 PF00886.14 KII61422.1 - 1.1e-19 69.9 0.0 1.4e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 DUF378 PF04070.7 KII61422.1 - 0.037 13.6 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF378) ATP-synt_F PF01990.12 KII61423.1 - 7e-25 87.2 0.1 9.2e-25 86.8 0.1 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit IBP39 PF11422.3 KII61424.1 - 0.087 12.3 0.6 0.15 11.5 0.4 1.5 1 1 0 1 1 1 0 Initiator binding protein 39 kDa Tropomyosin_1 PF12718.2 KII61425.1 - 6.1 6.6 39.6 5.8 6.7 7.1 4.4 3 1 2 5 5 5 0 Tropomyosin like Ofd1_CTDD PF10637.4 KII61426.1 - 0.0034 16.5 0.3 0.0048 16.0 0.2 1.2 1 0 0 1 1 1 1 Oxoglutarate and iron-dependent oxygenase degradation C-term DRY_EERY PF09750.4 KII61427.1 - 5.5e-09 36.1 0.3 5.5e-09 36.1 0.2 3.8 2 2 0 2 2 2 1 Alternative splicing regulator Mit_KHE1 PF10173.4 KII61427.1 - 0.012 15.5 0.6 0.062 13.1 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related YchF-GTPase_C PF06071.8 KII61428.1 - 3.4e-32 110.0 3.0 6.2e-32 109.2 2.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF933) TGS PF02824.16 KII61428.1 - 0.0026 17.5 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 KII61429.1 - 3.1e-19 69.0 0.0 3.8e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KII61429.1 - 9.3e-07 28.2 0.0 1.6e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KII61429.1 - 3.1e-05 23.8 0.0 0.14 11.9 0.0 2.4 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 KII61429.1 - 0.028 14.9 0.0 0.051 14.0 0.0 1.7 1 1 0 1 1 1 0 Miro-like protein RRM_1 PF00076.17 KII61430.1 - 6.6e-15 54.5 0.0 8.7e-15 54.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII61430.1 - 2.2e-13 50.0 0.0 2.8e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII61430.1 - 0.0017 18.2 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_trans_4_2 PF13477.1 KII61430.1 - 0.087 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like Ribosomal_L21p PF00829.16 KII61431.1 - 3.7e-18 65.4 0.9 6e-18 64.7 0.6 1.4 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein E1-E2_ATPase PF00122.15 KII61432.1 - 6.6e-39 133.2 0.7 2.9e-38 131.1 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.21 KII61432.1 - 4.7e-08 33.0 0.6 1.3e-07 31.6 0.4 1.8 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase PF00702.21 KII61432.1 - 0.00023 21.6 0.0 0.00044 20.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase RhoGAP PF00620.22 KII61433.1 - 2.1e-07 30.6 0.4 4.6e-07 29.5 0.1 1.7 2 1 1 3 3 3 1 RhoGAP domain BAR PF03114.13 KII61433.1 - 4.2e-06 26.4 0.7 8.6e-06 25.4 0.4 1.5 1 1 1 2 2 2 1 BAR domain RhoGAP PF00620.22 KII61434.1 - 5.4e-26 91.0 0.0 7.2e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain Pkinase PF00069.20 KII61435.1 - 9.7e-12 44.5 0.0 1.3e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII61435.1 - 2.1e-07 30.2 0.0 2.7e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_S10 PF00338.17 KII61436.1 - 3.6e-19 68.4 0.0 4.7e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Peptidase_M50 PF02163.17 KII61437.1 - 1.5e-07 30.6 10.9 1.9e-05 23.7 1.5 2.2 1 1 1 2 2 2 2 Peptidase family M50 Ribosomal_L36e PF01158.13 KII61438.1 - 2.3e-37 126.9 6.8 2.7e-37 126.6 4.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Ribosomal_S30 PF04758.9 KII61438.1 - 0.82 9.4 6.5 0.14 11.9 1.0 2.2 1 1 1 3 3 3 0 Ribosomal protein S30 Peptidase_S9 PF00326.16 KII61439.1 - 5.3e-34 117.3 0.0 6.5e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KII61439.1 - 3.1e-08 33.5 0.0 3.9e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KII61439.1 - 4.7e-07 29.9 0.0 6.4e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII61439.1 - 8.2e-06 25.5 0.0 3e-05 23.6 0.0 1.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.15 KII61439.1 - 0.001 18.5 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.11 KII61439.1 - 0.0031 16.9 0.0 0.31 10.4 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S28 PF05577.7 KII61439.1 - 0.0049 15.4 0.0 0.0054 15.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 DUF2920 PF11144.3 KII61439.1 - 0.0079 15.2 0.1 0.032 13.2 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2920) Peptidase_S15 PF02129.13 KII61439.1 - 0.021 14.2 0.1 2 7.7 0.0 2.1 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF3802 PF12290.3 KII61439.1 - 0.062 13.6 0.0 0.092 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) DPPIV_N PF00930.16 KII61440.1 - 2.2e-52 177.7 0.2 4.1e-52 176.9 0.1 1.4 1 1 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF501 PF04417.7 KII61441.1 - 0.088 12.6 3.6 0.11 12.3 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF501) NPV_P10 PF05531.7 KII61441.1 - 1.3 9.3 10.2 0.1 12.8 0.4 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein RNA_pol_Rpb1_2 PF00623.15 KII61441.1 - 2.5 8.0 9.0 0.51 10.2 1.7 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 2 BLOC1_2 PF10046.4 KII61441.1 - 9.4 6.4 17.2 9.5 6.4 2.6 3.3 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Na_H_Exchanger PF00999.16 KII61442.1 - 4.4e-41 140.6 27.5 5.1e-41 140.4 19.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family rve PF00665.21 KII61443.1 - 1.9e-25 89.3 0.0 3.6e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII61443.1 - 0.0026 17.2 0.0 0.01 15.3 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain RRM_1 PF00076.17 KII61445.1 - 3.2e-13 49.1 0.0 4.9e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII61445.1 - 3e-07 30.3 0.0 5.1e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII61445.1 - 0.00019 21.2 0.0 0.00028 20.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDE_3 PF13358.1 KII61446.1 - 1.4e-12 47.5 0.0 2.3e-12 46.9 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF1335 PF07056.6 KII61446.1 - 0.084 12.6 0.4 2 8.1 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1335) HTH_Tnp_Tc3_2 PF01498.13 KII61447.1 - 0.002 18.1 0.0 0.0044 17.0 0.0 1.7 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.1 KII61447.1 - 0.0072 15.8 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix Pico_P2B PF01552.12 KII61447.1 - 0.03 14.4 0.7 0.049 13.7 0.5 1.6 1 1 0 1 1 1 0 Picornavirus 2B protein Abhydrolase_6 PF12697.2 KII61448.1 - 2.2e-21 76.7 0.0 4.2e-21 75.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII61448.1 - 1.7e-13 50.7 0.0 1.2e-12 47.9 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KII61448.1 - 1.9e-12 47.1 0.0 6.5e-12 45.4 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.9 KII61448.1 - 0.0001 20.9 0.0 0.00016 20.2 0.0 1.3 1 0 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.3 KII61448.1 - 0.00036 20.3 0.0 0.00068 19.4 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydro_lipase PF04083.11 KII61448.1 - 0.01 15.1 0.0 0.033 13.5 0.0 1.8 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region BAAT_C PF08840.6 KII61448.1 - 0.024 14.3 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1057 PF06342.7 KII61448.1 - 0.035 12.9 0.0 0.068 11.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) PGAP1 PF07819.8 KII61448.1 - 0.073 12.6 0.1 0.24 10.9 0.0 1.8 1 1 0 1 1 1 0 PGAP1-like protein DUF2305 PF10230.4 KII61448.1 - 0.082 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Abhydrolase_3 PF07859.8 KII61448.1 - 0.099 12.2 0.0 0.37 10.3 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 KII61448.1 - 0.15 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) RVT_1 PF00078.22 KII61450.1 - 2.5e-09 36.7 0.0 6.8e-09 35.3 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Isochorismatase PF00857.15 KII61451.1 - 5.5e-25 88.3 0.3 3e-24 85.8 0.2 1.9 1 1 0 1 1 1 1 Isochorismatase family TFIIS_C PF01096.13 KII61452.1 - 0.046 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) DDE_Tnp_IS1595 PF12762.2 KII61452.1 - 0.049 13.4 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 ISXO2-like transposase domain His_Phos_2 PF00328.17 KII61453.1 - 3.6e-20 72.5 0.0 5.1e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.17 KII61454.1 - 1.7e-13 50.6 0.9 2.3e-13 50.2 0.6 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) N2227 PF07942.7 KII61454.1 - 0.009 14.9 0.6 0.013 14.4 0.4 1.4 1 1 0 1 1 1 1 N2227-like protein Pkinase PF00069.20 KII61455.1 - 8.9e-39 133.2 0.0 9.5e-39 133.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII61455.1 - 5.1e-26 91.3 0.0 6.3e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII61455.1 - 0.0052 15.7 0.0 0.0068 15.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Ribosomal_L7Ae PF01248.21 KII61456.1 - 3.5e-20 71.3 0.0 4.4e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FOLN PF09289.5 KII61456.1 - 0.087 12.6 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 Follistatin/Osteonectin-like EGF domain HEAT_2 PF13646.1 KII61459.1 - 1.1e-07 32.0 0.0 0.0023 18.1 0.0 3.8 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.17 KII61459.1 - 1.2e-07 31.2 3.9 0.012 15.6 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 KII61459.1 - 6.1e-06 26.5 0.0 0.0019 18.6 0.0 4.3 3 1 1 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KII61459.1 - 0.00064 20.0 3.8 0.061 13.7 0.0 3.8 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region IBN_N PF03810.14 KII61459.1 - 0.013 15.3 2.2 1.1 9.2 0.3 3.6 3 2 0 4 4 4 0 Importin-beta N-terminal domain HEAT PF02985.17 KII61460.1 - 2.4e-06 27.1 1.6 0.021 14.8 0.0 4.7 4 1 0 4 4 4 2 HEAT repeat CLASP_N PF12348.3 KII61460.1 - 3.9e-06 26.3 0.0 0.0014 18.0 0.0 3.3 2 1 1 3 3 3 1 CLASP N terminal Vac14_Fab1_bd PF12755.2 KII61460.1 - 0.01 16.1 0.5 3.3 8.1 0.0 3.6 3 2 1 4 4 4 0 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.1 KII61460.1 - 0.02 15.1 0.0 1.5 9.1 0.0 3.0 2 0 0 2 2 2 0 HEAT repeats HEAT_EZ PF13513.1 KII61460.1 - 0.034 14.6 0.3 14 6.3 0.0 3.8 3 2 1 4 4 4 0 HEAT-like repeat Ipi1_N PF12333.3 KII61460.1 - 0.038 13.9 0.0 1.3 9.0 0.0 2.7 2 1 1 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation Cohesin_HEAT PF12765.2 KII61460.1 - 0.094 12.7 0.7 0.36 10.8 0.1 2.3 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Glyco_hydro_57 PF03065.10 KII61461.1 - 0.11 11.3 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 EGF PF00008.22 KII61462.1 - 0.0029 17.5 9.6 0.0029 17.5 6.6 4.8 4 1 1 5 5 5 2 EGF-like domain EGF_2 PF07974.8 KII61462.1 - 0.059 13.5 10.1 0.059 13.5 7.0 5.2 3 2 1 4 4 4 0 EGF-like domain hEGF PF12661.2 KII61462.1 - 0.088 12.9 27.3 0.2 11.7 0.7 6.0 5 1 0 5 5 5 0 Human growth factor-like EGF PAZ PF02170.17 KII61465.1 - 0.042 13.1 0.0 0.05 12.9 0.0 1.2 1 0 0 1 1 1 0 PAZ domain Hexokinase_2 PF03727.11 KII61468.1 - 6.8e-53 179.3 0.2 5.5e-43 146.9 0.0 2.1 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.16 KII61468.1 - 8.9e-32 110.0 0.0 1.3e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase SapB_1 PF05184.10 KII61468.1 - 0.19 11.6 2.3 16 5.4 0.4 3.0 2 0 0 2 2 2 0 Saposin-like type B, region 1 Diphthamide_syn PF01866.12 KII61469.1 - 1.8e-14 53.7 0.0 2.4e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein zf-DNL PF05180.7 KII61469.1 - 0.1 12.3 0.1 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 DNL zinc finger CwfJ_C_1 PF04677.10 KII61470.1 - 2.1e-12 46.7 0.5 3.6e-12 45.9 0.4 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 TAFII28 PF04719.9 KII61471.1 - 1.8e-16 59.6 0.0 2.3e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 hTAFII28-like protein conserved region Histone PF00125.19 KII61471.1 - 0.00037 20.5 0.0 0.0005 20.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KII61471.1 - 0.0066 16.4 0.9 0.0066 16.4 0.6 1.8 1 1 1 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF3381 PF11861.3 KII61472.1 - 0.031 13.7 0.0 0.038 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF3505 PF12013.3 KII61473.1 - 0.018 15.2 0.1 0.033 14.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3505) EF1_GNE PF00736.14 KII61474.1 - 2.2e-23 81.7 4.3 2.2e-23 81.7 3.0 1.6 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain Allexi_40kDa PF05549.6 KII61474.1 - 0.0017 17.6 0.1 0.003 16.8 0.1 1.4 1 0 0 1 1 1 1 Allexivirus 40kDa protein DUF16 PF01519.11 KII61474.1 - 0.037 14.2 0.9 0.13 12.4 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF16 WD40 PF00400.27 KII61475.1 - 3.8e-06 26.5 5.5 0.031 14.1 0.2 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Collagen PF01391.13 KII61476.1 - 3.3e-06 26.5 15.3 5.5e-06 25.8 10.6 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) RPAP1_N PF08621.5 KII61476.1 - 1.2 8.7 7.2 0.94 9.1 0.1 3.0 3 0 0 3 3 3 0 RPAP1-like, N-terminal Pkinase PF00069.20 KII61478.1 - 2.6e-67 226.7 0.0 3e-67 226.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII61478.1 - 3.5e-29 101.6 0.0 4.4e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII61478.1 - 0.0001 21.3 0.0 0.21 10.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Mito_carr PF00153.22 KII61479.1 - 2.8e-46 155.1 5.1 6.6e-20 70.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_39 PF01229.12 KII61481.1 - 0.057 11.8 0.0 0.057 11.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 EF-hand_7 PF13499.1 KII61482.1 - 5.5e-12 45.6 0.0 1.4e-05 25.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KII61482.1 - 4.8e-09 35.3 0.5 0.0052 16.5 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KII61482.1 - 2.7e-07 29.3 0.0 0.015 14.5 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KII61482.1 - 0.0053 16.3 0.0 0.085 12.4 0.0 2.5 2 1 1 3 3 3 1 EF-hand domain pair Bromodomain PF00439.20 KII61483.1 - 2.8e-23 81.6 2.7 2.8e-23 81.6 1.9 2.9 3 0 0 3 3 3 1 Bromodomain PHD PF00628.24 KII61483.1 - 8.9e-09 34.9 27.1 0.00017 21.1 4.2 2.6 2 0 0 2 2 2 2 PHD-finger MBD PF01429.14 KII61483.1 - 3.2e-05 23.3 0.0 0.0001 21.7 0.0 1.9 1 0 0 1 1 1 1 Methyl-CpG binding domain DDT PF02791.12 KII61483.1 - 0.02 14.6 1.5 0.046 13.4 0.3 2.3 2 0 0 2 2 2 0 DDT domain PHD_2 PF13831.1 KII61483.1 - 0.027 13.7 20.2 0.092 12.0 0.8 3.4 3 0 0 3 3 3 0 PHD-finger C1_1 PF00130.17 KII61483.1 - 0.8 9.4 27.8 0.12 12.1 2.9 3.2 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) P34-Arc PF04045.9 KII61485.1 - 3.9e-45 154.0 0.0 5e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc CoaE PF01121.15 KII61486.1 - 3.1e-33 114.6 0.0 5.1e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase CTP_transf_2 PF01467.21 KII61486.1 - 9.2e-08 32.2 0.1 4.8e-06 26.7 0.0 2.8 3 0 0 3 3 3 1 Cytidylyltransferase AAA_18 PF13238.1 KII61486.1 - 3.3e-05 24.2 2.0 0.00043 20.5 0.6 2.8 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KII61486.1 - 9.2e-05 23.2 2.2 0.00078 20.2 0.4 3.0 2 2 0 2 2 2 1 AAA domain FAD_syn PF06574.7 KII61486.1 - 0.022 14.3 0.5 0.097 12.2 0.2 2.0 1 1 1 2 2 2 0 FAD synthetase Guanylate_kin PF00625.16 KII61487.1 - 2.5e-18 66.1 0.0 2.7e-18 66.0 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase TPR_1 PF00515.23 KII61488.1 - 9.7e-05 21.8 0.5 0.0011 18.4 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII61488.1 - 0.00011 21.7 2.1 0.00049 19.6 0.0 2.6 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KII61488.1 - 0.062 13.2 1.4 0.18 11.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Colicin_D PF11429.3 KII61488.1 - 0.1 12.7 1.0 2.4 8.3 0.0 3.0 3 0 0 3 3 3 0 Colicin D Ribosomal_L50 PF10501.4 KII61488.1 - 0.41 10.6 0.1 0.41 10.6 0.0 2.9 3 0 0 3 3 3 0 Ribosomal subunit 39S DUF2545 PF10810.3 KII61489.1 - 0.14 12.5 3.9 1.8 9.0 2.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2545) LRR_9 PF14580.1 KII61490.1 - 1.3e-56 190.8 1.3 1.7e-56 190.5 0.9 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 KII61490.1 - 1.2e-11 43.9 12.2 2.7e-05 23.6 3.0 3.8 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KII61490.1 - 3.6e-07 29.8 12.3 1.5e-06 27.8 3.4 3.2 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KII61490.1 - 0.00012 21.6 8.2 0.48 10.6 0.5 4.4 3 2 1 4 4 4 2 Leucine Rich Repeat CRAL_TRIO PF00650.15 KII61490.1 - 0.082 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 CRAL/TRIO domain LRR_7 PF13504.1 KII61490.1 - 1.6 9.2 11.6 6.6 7.4 0.4 5.3 6 0 0 6 6 6 0 Leucine rich repeat LRR_6 PF13516.1 KII61490.1 - 7.6 6.9 14.2 4 7.8 0.5 4.6 3 1 2 5 5 5 0 Leucine Rich repeat GNAT_acetyltr_2 PF13718.1 KII61491.1 - 4.1e-73 244.8 0.0 7.8e-73 243.9 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 KII61491.1 - 1.1e-56 191.2 0.0 2.4e-56 190.1 0.0 1.6 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.6 KII61491.1 - 4.7e-33 112.7 0.3 1.3e-32 111.3 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 KII61491.1 - 1e-21 76.9 1.3 2.8e-21 75.4 0.9 1.8 1 0 0 1 1 1 1 Possible tRNA binding domain AAA_22 PF13401.1 KII61491.1 - 0.007 16.5 0.1 0.24 11.5 0.0 3.0 2 1 1 3 3 3 1 AAA domain Acetyltransf_7 PF13508.1 KII61491.1 - 0.027 14.6 0.0 0.25 11.5 0.0 2.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KII61491.1 - 0.067 13.2 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Bac_small_YrzI PF09501.5 KII61492.1 - 0.38 10.7 5.2 0.94 9.4 3.6 1.8 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) Borrelia_lipo_2 PF06238.6 KII61492.1 - 2 8.4 4.7 0.72 9.9 1.5 1.6 2 0 0 2 2 2 0 Borrelia burgdorferi BBR25 lipoprotein Ribosomal_L18p PF00861.17 KII61493.1 - 5.4e-40 136.3 3.1 8.6e-40 135.6 0.4 2.1 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 KII61493.1 - 4.8e-28 97.5 5.0 4.8e-28 97.5 3.5 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region EGF_2 PF07974.8 KII61495.1 - 0.0004 20.4 11.3 0.0004 20.4 7.8 3.5 3 1 0 3 3 3 1 EGF-like domain FAM24 PF15193.1 KII61495.1 - 5.7 7.1 8.8 16 5.7 4.7 2.3 1 1 1 2 2 2 0 FAM24 family Actin PF00022.14 KII61497.1 - 5.8e-162 538.6 0.0 6.5e-162 538.4 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 KII61497.1 - 0.078 13.3 0.0 0.18 12.1 0.0 1.6 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) HALZ PF02183.13 KII61498.1 - 0.11 12.2 1.5 0.19 11.4 1.0 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Pox_A_type_inc PF04508.7 KII61498.1 - 0.14 12.0 3.0 0.16 11.8 0.9 2.1 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DivIC PF04977.10 KII61498.1 - 0.91 9.0 4.4 0.54 9.7 1.7 1.7 2 0 0 2 2 2 0 Septum formation initiator WD40 PF00400.27 KII61499.1 - 2.6e-09 36.6 3.4 0.0055 16.5 0.2 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat eIF2A PF08662.6 KII61499.1 - 1.9e-05 24.4 0.3 0.14 11.8 0.0 3.0 1 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ank_2 PF12796.2 KII61501.1 - 3.2e-27 94.7 0.7 2.3e-13 50.2 0.1 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KII61501.1 - 1.6e-13 49.7 0.5 2.7e-06 26.9 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 KII61501.1 - 8e-13 47.2 3.1 0.00035 20.5 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.1 KII61501.1 - 7.4e-11 42.2 0.3 6e-05 23.4 0.0 2.8 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII61501.1 - 7.5e-08 32.3 0.1 0.00052 20.1 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) YcbB PF08664.5 KII61501.1 - 0.016 14.9 0.2 0.038 13.7 0.1 1.6 1 0 0 1 1 1 0 YcbB domain zf-C3HC4_2 PF13923.1 KII61502.1 - 9.4e-10 38.3 12.1 1.6e-09 37.5 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KII61502.1 - 7.5e-09 35.1 7.8 1.3e-08 34.3 5.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KII61502.1 - 3.1e-08 33.2 9.7 5.2e-08 32.5 6.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-CCCH PF00642.19 KII61502.1 - 9.5e-08 31.5 2.0 2.4e-07 30.2 1.4 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4 PF00097.20 KII61502.1 - 1.3e-06 27.9 13.5 2.4e-06 27.1 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KII61502.1 - 8.5e-05 22.1 13.0 0.00016 21.3 9.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KII61502.1 - 0.00013 21.7 8.7 0.00027 20.7 6.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 KII61502.1 - 0.00056 19.3 5.6 0.0009 18.7 3.9 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KII61502.1 - 0.00066 19.3 7.6 0.0013 18.4 5.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger BmKX PF09132.5 KII61502.1 - 0.035 13.9 0.5 0.035 13.9 0.3 2.5 2 1 0 2 2 2 0 BmKX Kp4 PF09044.5 KII61502.1 - 0.058 13.2 0.9 0.1 12.4 0.7 1.5 1 0 0 1 1 1 0 Kp4 zf-rbx1 PF12678.2 KII61502.1 - 0.13 12.4 10.1 0.5 10.5 7.0 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger IRK_N PF08466.5 KII61502.1 - 0.13 12.1 0.3 0.3 11.0 0.0 1.8 2 0 0 2 2 2 0 Inward rectifier potassium channel N-terminal zf-RING_6 PF14835.1 KII61502.1 - 0.64 9.8 4.4 1.1 9.0 3.0 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein GTP_EFTU_D3 PF03143.12 KII61504.1 - 5.4e-10 39.3 0.0 9.6e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.22 KII61504.1 - 6.8e-07 28.8 0.0 8.9e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KII61504.1 - 0.071 12.2 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region E1_DerP2_DerF2 PF02221.10 KII61507.1 - 0.0004 20.6 0.2 0.0012 19.0 0.1 1.7 1 1 0 1 1 1 1 ML domain DDE_Tnp_IS1595 PF12762.2 KII61508.1 - 8.5e-10 38.6 0.0 2.1e-08 34.1 0.0 2.3 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF1882 PF08966.6 KII61511.1 - 0.13 12.2 0.3 0.2 11.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) Ank_3 PF13606.1 KII61512.1 - 1.3e-09 37.3 0.1 2e-07 30.5 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.2 KII61512.1 - 3.2e-07 30.6 0.1 7.6e-07 29.3 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KII61512.1 - 3.7e-06 26.9 0.1 0.0009 19.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KII61512.1 - 7.3e-06 26.3 0.2 0.012 16.1 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KII61512.1 - 0.0013 18.4 0.0 0.004 16.8 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Helicase_C PF00271.26 KII61513.1 - 3.7e-28 97.1 0.0 1.1e-27 95.6 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KII61513.1 - 1.6e-18 66.7 0.0 7.4e-18 64.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KII61513.1 - 0.042 13.9 0.0 0.083 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Calcipressin PF04847.7 KII61514.1 - 7.2e-11 42.0 0.0 9.4e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 Calcipressin MULE PF10551.4 KII61515.1 - 5.3e-06 26.5 0.0 1.5e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 MULE transposase domain CWC25 PF12542.3 KII61516.1 - 0.075 13.4 1.3 0.12 12.7 0.9 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing factor DDE_Tnp_IS1595 PF12762.2 KII61517.1 - 0.00055 19.7 0.3 0.0007 19.4 0.2 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain HECT PF00632.20 KII61518.1 - 1.2e-89 300.6 1.0 1.7e-89 300.0 0.7 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 KII61518.1 - 8.1e-16 57.5 4.3 1.2e-07 31.4 0.2 2.6 2 0 0 2 2 2 2 WW domain Lep_receptor_Ig PF06328.6 KII61518.1 - 0.1 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Ig-like C2-type domain hDGE_amylase PF14701.1 KII61519.1 - 1.5e-125 419.4 0.8 2.1e-125 418.9 0.6 1.2 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme Alpha-amylase PF00128.19 KII61519.1 - 1.9e-09 37.4 0.6 0.00027 20.4 0.3 2.4 2 0 0 2 2 2 2 Alpha amylase, catalytic domain hGDE_N PF14699.1 KII61519.1 - 1.4e-07 31.2 0.2 2.8e-07 30.2 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme hGDE_central PF14702.1 KII61520.1 - 1.4e-22 80.1 0.9 7.3e-22 77.7 0.6 1.8 1 1 0 1 1 1 1 central domain of human glycogen debranching enzyme DDE_Tnp_IS1595 PF12762.2 KII61524.1 - 2.9e-22 79.1 0.0 3.6e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII61524.1 - 0.037 13.7 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease RFX_DNA_binding PF02257.10 KII61525.1 - 2.1e-22 79.0 0.1 5.8e-22 77.6 0.1 1.8 1 0 0 1 1 1 1 RFX DNA-binding domain Ldl_recept_a PF00057.13 KII61526.1 - 1.4e-42 143.2 110.7 4.6e-10 39.2 4.5 8.3 8 1 0 8 8 8 7 Low-density lipoprotein receptor domain class A PEX11 PF05648.9 KII61526.1 - 0.049 12.8 0.0 0.084 12.1 0.0 1.3 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Serpin PF00079.15 KII61528.1 - 1.8e-27 96.4 1.8 2e-27 96.2 1.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CDT1 PF08839.6 KII61529.1 - 3.4e-34 118.1 0.3 1.1e-33 116.5 0.2 1.9 1 0 0 1 1 1 1 DNA replication factor CDT1 like Ribosomal_L10 PF00466.15 KII61530.1 - 9e-13 48.0 0.1 1.3e-12 47.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 DNA_mis_repair PF01119.14 KII61532.1 - 5.2e-24 83.9 0.4 1.5e-23 82.4 0.1 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 KII61532.1 - 1.4e-15 57.1 0.6 2.6e-14 53.0 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KII61532.1 - 2.4e-07 30.4 0.1 2.5e-06 27.1 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MULE PF10551.4 KII61533.1 - 4.9e-06 26.6 0.1 1.1e-05 25.5 0.0 1.6 1 1 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.12 KII61533.1 - 0.054 13.0 0.0 0.12 11.8 0.0 1.5 1 1 0 1 1 1 0 Transposase DUF1955 PF09205.5 KII61533.1 - 0.077 12.5 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) AviRa PF11599.3 KII61533.1 - 0.12 11.3 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa DDE_Tnp_IS1595 PF12762.2 KII61536.1 - 0.059 13.2 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain zf-U11-48K PF05253.7 KII61537.1 - 0.05 13.3 0.5 0.14 11.9 0.3 1.8 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger Folate_rec PF03024.9 KII61538.1 - 1e-07 31.7 2.3 1.1e-07 31.6 1.6 1.0 1 0 0 1 1 1 1 Folate receptor family Toxin_7 PF05980.7 KII61538.1 - 0.11 12.5 1.9 0.11 12.5 1.3 1.7 2 0 0 2 2 2 0 Toxin 7 TraW_N PF12477.3 KII61538.1 - 0.11 12.4 0.1 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Sex factor F TraW protein N terminal Adaptin_binding PF10199.4 KII61539.1 - 7.2e-08 32.7 4.9 0.00011 22.5 1.2 2.3 1 1 1 2 2 2 2 Alpha and gamma adaptin binding protein p34 RRM_1 PF00076.17 KII61540.1 - 1.1e-28 98.6 0.1 7e-17 60.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII61540.1 - 3e-23 81.5 0.1 9e-13 48.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII61540.1 - 7.4e-10 38.5 0.0 1.7e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII61540.1 - 0.00065 19.4 0.0 0.0091 15.7 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 KII61540.1 - 0.0023 17.7 0.8 0.023 14.5 0.0 2.5 3 0 0 3 3 3 1 RNA binding motif OB_RNB PF08206.6 KII61540.1 - 0.039 13.4 0.1 5.5 6.5 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain DDE_Tnp_IS1595 PF12762.2 KII61542.1 - 3.4e-08 33.4 0.1 2.6e-07 30.5 0.0 1.9 1 1 1 2 2 2 2 ISXO2-like transposase domain PPV_E2_C PF00511.12 KII61542.1 - 0.2 11.6 2.5 0.42 10.5 0.8 2.0 2 0 0 2 2 2 0 E2 (early) protein, C terminal UbiA PF01040.13 KII61543.1 - 7.1e-32 110.6 14.4 8.5e-32 110.3 10.0 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family Vps23_core PF09454.5 KII61544.1 - 6.5e-12 44.8 0.2 1.4e-11 43.8 0.0 1.7 2 0 0 2 2 2 1 Vps23 core domain UEV PF05743.8 KII61544.1 - 8.1e-06 25.5 0.0 1.8e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 UEV domain PRKCSH-like PF12999.2 KII61546.1 - 0.11 12.0 2.1 0.14 11.6 1.4 1.1 1 0 0 1 1 1 0 Glucosidase II beta subunit-like VWA_2 PF13519.1 KII61547.1 - 5.4e-08 33.1 0.1 7.9e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KII61547.1 - 0.0023 17.6 0.3 0.0033 17.1 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain G8 PF10162.4 KII61547.1 - 0.034 13.9 0.4 0.079 12.7 0.2 1.7 1 1 1 2 2 2 0 G8 domain DNA_photolyase PF00875.13 KII61547.1 - 0.16 11.6 0.5 0.41 10.3 0.1 1.7 2 0 0 2 2 2 0 DNA photolyase RVT_1 PF00078.22 KII61548.1 - 5.6e-19 68.3 0.0 1.6e-18 66.8 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4129 PF13559.1 KII61549.1 - 0.0042 17.0 0.1 0.0079 16.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) PIH1 PF08190.7 KII61550.1 - 3.9e-14 52.8 0.2 2.2e-12 47.0 0.0 2.1 2 0 0 2 2 2 2 pre-RNA processing PIH1/Nop17 Ank PF00023.25 KII61551.1 - 6.8e-12 44.5 0.0 2.7e-10 39.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 KII61551.1 - 2.5e-11 43.4 0.0 4.2e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KII61551.1 - 5.5e-11 42.6 0.2 5.1e-07 30.0 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KII61551.1 - 4.7e-08 33.2 0.0 5.3e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KII61551.1 - 1.8e-06 27.6 0.1 4.6e-05 23.2 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Imm29 PF15575.1 KII61551.1 - 0.064 12.8 0.0 0.072 12.6 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 29 RVP PF00077.15 KII61551.1 - 0.071 13.0 0.0 0.091 12.6 0.0 1.2 1 0 0 1 1 1 0 Retroviral aspartyl protease Ank_4 PF13637.1 KII61552.1 - 3.2e-06 27.5 0.2 7.3e-06 26.3 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KII61552.1 - 2.8e-05 24.3 0.0 3.4e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KII61552.1 - 0.00068 19.6 0.1 0.97 9.8 0.0 2.9 2 1 0 2 2 2 2 Ankyrin repeat Ank PF00023.25 KII61552.1 - 0.056 13.2 0.0 1 9.3 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat FAM60A PF15396.1 KII61553.1 - 1.2e-05 25.2 3.9 1.5e-05 24.8 0.0 2.0 1 1 1 2 2 2 1 Protein Family FAM60A FAM91_C PF14648.1 KII61554.1 - 1.6e-30 106.3 0.8 2.4e-30 105.7 0.6 1.3 1 0 0 1 1 1 1 FAM91 C-terminus FAM91_N PF14647.1 KII61554.1 - 4.8e-24 84.9 0.1 8.8e-24 84.1 0.0 1.4 1 0 0 1 1 1 1 FAM91 N-terminus Phage_rep_org_N PF09681.5 KII61554.1 - 0.016 14.7 1.3 0.024 14.2 0.1 1.9 2 0 0 2 2 2 0 N-terminal phage replisome organiser (Phage_rep_org_N) DUF4423 PF14394.1 KII61554.1 - 0.082 12.4 1.2 2.4 7.6 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4423) DUF4393 PF14337.1 KII61554.1 - 0.084 12.3 0.5 0.19 11.1 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4393) FAM91_C PF14648.1 KII61555.1 - 1.8e-46 158.9 0.2 1e-29 103.6 0.1 2.0 1 1 1 2 2 2 2 FAM91 C-terminus FGGY_N PF00370.16 KII61556.1 - 6.4e-28 97.7 0.1 8.1e-28 97.3 0.1 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Ribosomal_S4e PF00900.15 KII61558.1 - 1.3e-29 101.6 0.2 2.9e-29 100.5 0.2 1.6 1 0 0 1 1 1 1 Ribosomal family S4e KOW PF00467.24 KII61558.1 - 2.9e-06 26.7 3.6 4e-06 26.3 0.2 2.8 3 0 0 3 3 3 1 KOW motif Phage_attach PF05354.6 KII61558.1 - 0.014 14.9 0.1 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 Phage Head-Tail Attachment zf-tcix PF14952.1 KII61559.1 - 0.023 14.0 0.3 0.07 12.4 0.2 1.8 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding TraH PF06122.6 KII61559.1 - 0.13 11.0 2.9 0.76 8.5 0.0 2.0 1 1 1 2 2 2 0 Conjugative relaxosome accessory transposon protein zf-A20 PF01754.11 KII61559.1 - 0.92 9.1 6.0 0.26 10.8 0.3 2.4 2 0 0 2 2 2 0 A20-like zinc finger rve PF00665.21 KII61560.1 - 4.2e-22 78.4 0.0 9.2e-22 77.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Methyltransf_26 PF13659.1 KII61560.1 - 5.7e-07 29.5 0.0 1.1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 KII61560.1 - 8.9e-06 25.3 0.0 2.1e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.1 KII61560.1 - 0.00053 19.6 0.0 0.0018 17.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain zf-H2C2 PF09337.5 KII61560.1 - 0.00061 19.1 0.5 0.0017 17.7 0.4 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII61560.1 - 0.00098 18.6 0.0 0.0041 16.6 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain DUF3172 PF11371.3 KII61560.1 - 0.11 11.9 0.0 0.67 9.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3172) PHD PF00628.24 KII61563.1 - 8.8e-09 34.9 10.2 1.6e-08 34.1 7.1 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 KII61563.1 - 0.37 10.9 7.0 0.83 9.8 4.8 1.7 1 1 0 1 1 1 0 PHD-like zinc-binding domain DapH_N PF08503.5 KII61565.1 - 0.066 13.3 0.4 0.2 11.8 0.2 1.9 1 1 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal DUF3858 PF12970.2 KII61565.1 - 0.13 12.0 0.1 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3858) Kelch_1 PF01344.20 KII61569.1 - 5.4e-11 41.8 14.5 2e-05 24.0 0.5 4.5 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 KII61569.1 - 1.4e-10 41.0 3.2 7.4e-05 22.7 0.1 4.4 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII61569.1 - 2.9e-10 39.7 7.5 0.0003 20.4 0.1 4.3 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 KII61569.1 - 5.7e-10 38.9 10.2 0.00071 19.6 0.1 4.3 4 1 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 KII61569.1 - 1.6e-08 33.9 8.8 0.047 13.4 0.0 4.6 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.1 KII61569.1 - 0.0021 17.9 9.3 0.25 11.3 0.4 3.3 4 0 0 4 4 4 2 Kelch motif HECT PF00632.20 KII61570.1 - 0.036 13.2 0.4 0.037 13.1 0.2 1.1 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) NUT_N PF12881.2 KII61575.1 - 0.018 14.1 0.1 0.027 13.6 0.1 1.2 1 0 0 1 1 1 0 NUT protein N terminus Cut8_C PF08559.5 KII61577.1 - 0.004 16.9 0.1 0.048 13.4 0.0 2.0 1 1 1 2 2 2 1 Cut8 six-helix bundle DUF2013 PF09431.5 KII61578.1 - 0.025 14.3 0.0 0.1 12.3 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2013) Flagellar_rod PF05149.7 KII61582.1 - 0.032 13.4 0.2 0.07 12.3 0.2 1.6 2 0 0 2 2 2 0 Paraflagellar rod protein TACI-CRD2 PF09305.5 KII61583.1 - 2.1 8.2 7.5 6.5 6.6 0.6 2.5 2 0 0 2 2 2 0 TACI, cysteine-rich domain RRXRR PF14239.1 KII61583.1 - 2.5 7.4 5.4 3.8 6.8 3.8 1.2 1 0 0 1 1 1 0 RRXRR protein RVP PF00077.15 KII61584.1 - 1.1e-05 25.3 0.0 2.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII61584.1 - 0.072 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease PRANC PF09372.5 KII61585.1 - 0.11 12.4 2.4 0.57 10.1 0.1 2.5 2 1 0 2 2 2 0 PRANC domain TFIIF_beta PF02270.10 KII61586.1 - 5e-35 121.6 0.2 7.2e-31 108.0 0.2 2.0 1 1 1 2 2 2 2 Transcription initiation factor IIF, beta subunit BSD PF03909.12 KII61587.1 - 3.1e-05 23.6 0.1 3.1e-05 23.6 0.1 1.8 3 0 0 3 3 3 1 BSD domain DUF1357 PF07094.6 KII61588.1 - 0.41 10.0 7.3 0.1 12.0 2.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1357) Cyclin_N PF00134.18 KII61589.1 - 2.6e-06 27.0 1.3 4.3e-06 26.3 0.9 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain A2M_N_2 PF07703.9 KII61589.1 - 0.097 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Alpha-2-macroglobulin family N-terminal region Exo70 PF03081.10 KII61590.1 - 4.1e-07 29.1 1.5 4.5e-07 28.9 1.0 1.0 1 0 0 1 1 1 1 Exo70 exocyst complex subunit DUF2151 PF10221.4 KII61590.1 - 0.0097 14.1 0.5 0.011 14.0 0.3 1.1 1 0 0 1 1 1 1 Cell cycle and development regulator Prefoldin_2 PF01920.15 KII61590.1 - 0.025 14.3 0.7 0.035 13.8 0.5 1.2 1 0 0 1 1 1 0 Prefoldin subunit DUF2262 PF10020.4 KII61590.1 - 0.039 14.1 0.3 0.053 13.7 0.2 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) AChE_tetra PF08674.5 KII61590.1 - 0.061 12.8 0.3 1 8.9 0.1 2.2 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain DUF1040 PF06288.8 KII61590.1 - 0.11 12.7 0.8 3 8.1 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1040) Sedlin_N PF04628.8 KII61590.1 - 0.16 11.8 1.6 0.78 9.6 0.1 2.1 1 1 1 2 2 2 0 Sedlin, N-terminal conserved region T2SG PF08334.6 KII61590.1 - 0.17 11.6 0.7 1 9.1 0.1 2.0 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein G Fib_alpha PF08702.5 KII61590.1 - 0.65 10.1 3.4 1.2 9.1 2.5 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family AdoHcyase PF05221.12 KII61591.1 - 0.015 14.3 0.0 0.016 14.1 0.0 1.1 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase Integrin_alpha2 PF08441.7 KII61592.1 - 2e-23 82.9 0.1 3.1e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.18 KII61592.1 - 0.00095 18.7 0.1 0.0023 17.5 0.1 1.7 1 0 0 1 1 1 1 FG-GAP repeat DUF3902 PF13042.1 KII61593.1 - 0.021 14.0 5.0 0.028 13.7 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3902) COX2_TM PF02790.10 KII61593.1 - 0.11 12.4 1.0 0.18 11.8 0.7 1.5 1 1 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain DUF872 PF05915.7 KII61593.1 - 0.13 12.1 0.9 0.15 11.9 0.6 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) EamA PF00892.15 KII61593.1 - 0.15 12.1 6.2 0.21 11.6 4.3 1.2 1 0 0 1 1 1 0 EamA-like transporter family DUF4418 PF14387.1 KII61593.1 - 0.21 11.3 1.9 0.26 11.0 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4418) DUF2871 PF11070.3 KII61593.1 - 0.55 10.4 4.4 0.69 10.0 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) DUF381 PF04038.7 KII61595.1 - 0.1 12.6 0.5 0.79 9.8 0.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF381) IU_nuc_hydro PF01156.14 KII61596.1 - 5.9e-46 157.1 0.0 6.7e-46 156.9 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DDE_3 PF13358.1 KII61597.1 - 0.002 17.9 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease LRR_4 PF12799.2 KII61597.1 - 0.096 12.3 0.3 0.2 11.3 0.2 1.5 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) Transglut_N PF00868.15 KII61598.1 - 0.0022 18.0 0.0 0.0051 16.8 0.0 1.6 1 1 0 1 1 1 1 Transglutaminase family IU_nuc_hydro PF01156.14 KII61600.1 - 2.9e-39 135.1 0.0 3.8e-38 131.4 0.0 1.9 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF1904 PF08921.6 KII61601.1 - 0.015 15.3 0.5 0.071 13.1 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1904) RVT_1 PF00078.22 KII61603.1 - 0.00076 18.8 0.0 0.0015 17.9 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MbeB_N PF04837.7 KII61604.1 - 0.039 14.0 0.2 0.075 13.1 0.2 1.5 1 0 0 1 1 1 0 MbeB-like, N-term conserved region HycI PF01750.13 KII61604.1 - 0.098 12.2 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase maturation protease Sec63 PF02889.11 KII61605.1 - 1.2e-06 28.0 0.1 1.2e-06 27.9 0.1 1.1 1 0 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.26 KII61606.1 - 1.9e-11 43.4 0.0 2.8e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Herpes_glycop PF01528.11 KII61606.1 - 0.013 14.2 0.0 0.015 14.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M DUF1673 PF07895.6 KII61606.1 - 0.013 15.0 0.3 0.019 14.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) DUF2206 PF09971.4 KII61606.1 - 0.021 13.6 0.1 0.029 13.2 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) RVP PF00077.15 KII61607.1 - 1.9e-08 34.1 0.0 3.8e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII61607.1 - 6.1e-07 29.8 0.0 1.3e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 KII61607.1 - 1e-06 28.6 0.0 2.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII61607.1 - 2e-06 27.3 0.1 8.8e-06 25.2 0.1 1.9 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII61607.1 - 2e-05 24.3 0.0 0.00025 20.7 0.0 2.3 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease FYVE_2 PF02318.11 KII61607.1 - 0.026 14.4 0.1 0.054 13.3 0.1 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Peptidase_A3 PF02160.10 KII61607.1 - 0.035 13.6 0.2 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 Cauliflower mosaic virus peptidase (A3) zf-CCHC PF00098.18 KII61607.1 - 0.087 12.7 5.8 0.17 11.8 4.0 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.1 KII61607.1 - 0.17 11.5 4.8 0.35 10.5 3.3 1.5 1 0 0 1 1 1 0 Zinc knuckle Orthoreo_P17 PF07272.6 KII61608.1 - 0.0033 17.2 0.3 0.0039 16.9 0.2 1.1 1 0 0 1 1 1 1 Orthoreovirus P17 protein Neurochondrin PF05536.6 KII61608.1 - 0.033 12.5 0.1 0.036 12.3 0.1 1.1 1 0 0 1 1 1 0 Neurochondrin TMEM71 PF15121.1 KII61609.1 - 0.024 14.3 0.4 0.033 13.9 0.3 1.2 1 0 0 1 1 1 0 TMEM71 protein family Chlam_vir PF05475.6 KII61610.1 - 0.14 11.2 0.8 0.19 10.7 0.6 1.2 1 0 0 1 1 1 0 Chlamydia virulence protein PGP3-D TMF_TATA_bd PF12325.3 KII61612.1 - 0.00013 21.6 18.4 0.00082 19.1 3.2 3.1 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.4 KII61612.1 - 0.00025 20.9 23.9 0.083 12.7 6.5 2.6 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.1 KII61612.1 - 0.0003 19.4 15.1 0.00035 19.1 10.5 1.1 1 0 0 1 1 1 1 AAA domain GAS PF13851.1 KII61612.1 - 0.00046 19.4 20.6 0.0035 16.5 9.2 2.6 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding DUF869 PF05911.6 KII61612.1 - 0.00062 18.1 9.4 0.00062 18.1 6.5 1.8 1 1 0 1 1 1 1 Plant protein of unknown function (DUF869) Pkinase_C PF00433.19 KII61612.1 - 0.0015 19.0 0.3 0.005 17.3 0.2 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Tektin PF03148.9 KII61612.1 - 0.0016 17.0 14.5 0.0026 16.3 2.8 2.8 1 1 1 3 3 3 2 Tektin family Baculo_PEP_C PF04513.7 KII61612.1 - 0.0019 18.0 14.1 0.09 12.5 2.7 2.3 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Tropomyosin_1 PF12718.2 KII61612.1 - 0.0031 17.3 19.0 0.0047 16.7 12.7 1.6 1 1 0 1 1 1 1 Tropomyosin like IncA PF04156.9 KII61612.1 - 0.0064 16.1 24.0 0.075 12.6 4.0 2.2 1 1 1 2 2 2 2 IncA protein FTHFS PF01268.14 KII61612.1 - 0.0082 14.1 2.2 0.012 13.6 1.6 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase Cluap1 PF10234.4 KII61612.1 - 0.01 15.0 15.5 0.024 13.8 2.8 2.1 1 1 1 2 2 2 0 Clusterin-associated protein-1 RIC3 PF15361.1 KII61612.1 - 0.013 15.7 0.6 0.03 14.5 0.4 1.5 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Myosin_tail_1 PF01576.14 KII61612.1 - 0.014 13.1 21.2 0.13 9.9 14.6 2.0 1 1 0 1 1 1 0 Myosin tail FliJ PF02050.11 KII61612.1 - 0.015 15.3 10.2 0.15 12.1 0.1 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein CCDC155 PF14662.1 KII61612.1 - 0.046 13.3 22.7 0.11 12.0 15.7 1.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 SCP-1 PF05483.7 KII61612.1 - 0.056 11.2 18.9 0.13 9.9 12.4 1.7 1 1 1 2 2 2 0 Synaptonemal complex protein 1 (SCP-1) DUF1664 PF07889.7 KII61612.1 - 0.11 12.3 13.4 1.2 8.9 1.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3053 PF11254.3 KII61612.1 - 0.12 11.5 10.6 2.1 7.5 0.5 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3053) Apolipoprotein PF01442.13 KII61612.1 - 0.23 10.9 10.5 0.48 9.9 7.3 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Reo_sigmaC PF04582.7 KII61612.1 - 0.26 10.4 14.8 0.37 9.9 3.5 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Atg14 PF10186.4 KII61612.1 - 0.3 9.9 17.3 0.37 9.6 2.3 2.1 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Cep57_CLD_2 PF14197.1 KII61612.1 - 0.34 10.8 19.7 4.7 7.2 9.8 3.3 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Tropomyosin PF00261.15 KII61612.1 - 0.36 9.8 18.6 0.78 8.7 4.6 2.5 1 1 1 2 2 2 0 Tropomyosin Nup54 PF13874.1 KII61612.1 - 0.46 10.1 12.1 1.5 8.5 4.8 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Phage_GP20 PF06810.6 KII61612.1 - 0.57 9.6 20.7 0.39 10.1 0.9 3.2 1 1 2 3 3 3 0 Phage minor structural protein GP20 DUF4201 PF13870.1 KII61612.1 - 0.58 9.5 20.1 0.43 10.0 3.4 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) APG6 PF04111.7 KII61612.1 - 0.77 8.7 20.7 0.33 9.9 4.1 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF4140 PF13600.1 KII61612.1 - 0.77 10.2 9.4 1.4 9.3 1.4 2.9 1 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) RmuC PF02646.11 KII61612.1 - 1.3 7.7 13.1 3.6 6.3 3.4 2.3 1 1 2 3 3 3 0 RmuC family ADIP PF11559.3 KII61612.1 - 1.3 8.8 22.2 1.2 8.9 3.4 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Fib_alpha PF08702.5 KII61612.1 - 1.4 9.0 16.9 1.1 9.3 2.6 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 KII61612.1 - 1.5 8.7 28.0 0.78 9.5 7.7 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF972 PF06156.8 KII61612.1 - 1.5 9.1 18.6 8.9 6.7 4.4 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Ead_Ea22 PF13935.1 KII61612.1 - 1.5 9.1 6.8 1.4 9.2 2.6 2.3 2 1 1 3 3 2 0 Ead/Ea22-like protein NPV_P10 PF05531.7 KII61612.1 - 1.8 8.8 12.5 12 6.1 1.8 3.3 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein CALCOCO1 PF07888.6 KII61612.1 - 1.8 6.7 19.0 0.17 10.1 6.2 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.6 KII61612.1 - 2 6.9 22.8 0.17 10.5 5.8 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein PspA_IM30 PF04012.7 KII61612.1 - 2 7.7 12.5 1.8 7.8 3.4 2.3 1 1 0 1 1 1 0 PspA/IM30 family Streptin-Immun PF11083.3 KII61612.1 - 2.5 8.1 12.9 2.4 8.1 0.8 3.2 1 1 3 4 4 4 0 Lantibiotic streptin immunity protein DivIVA PF05103.8 KII61612.1 - 2.7 8.0 16.2 6.4 6.8 0.7 3.3 1 1 2 3 3 3 0 DivIVA protein TBPIP PF07106.8 KII61612.1 - 2.8 7.4 21.4 7.3 6.1 3.4 2.7 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Syntaxin PF00804.20 KII61612.1 - 2.9 8.1 18.5 1.5 9.0 3.4 2.7 1 1 1 2 2 2 0 Syntaxin DUF2968 PF11180.3 KII61612.1 - 3.1 7.1 9.7 3.8 6.8 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF3450 PF11932.3 KII61612.1 - 3.8 6.7 12.7 3.3 6.9 3.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ATG16 PF08614.6 KII61612.1 - 4 7.2 22.1 4.9e+02 0.3 14.7 2.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Cortex-I_coil PF09304.5 KII61612.1 - 4 7.5 20.7 0.34 10.9 3.6 3.0 1 1 0 2 2 2 0 Cortexillin I, coiled coil Rootletin PF15035.1 KII61612.1 - 4.3 7.2 20.5 1.3 9.0 3.1 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Bacillus_HBL PF05791.6 KII61612.1 - 4.9 6.4 17.2 4.7 6.5 2.5 2.3 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) NAD_binding_6 PF08030.7 KII61612.1 - 5.2 6.9 12.0 0.98 9.3 1.2 2.4 1 1 1 2 2 2 0 Ferric reductase NAD binding domain Seryl_tRNA_N PF02403.17 KII61612.1 - 5.4 7.0 16.2 3.9 7.5 1.5 3.0 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain SlyX PF04102.7 KII61612.1 - 5.6 7.4 12.6 3.8 7.9 0.3 3.0 1 1 2 3 3 3 0 SlyX YlqD PF11068.3 KII61612.1 - 6.7 6.7 13.5 1.8 8.5 4.3 2.5 1 1 1 2 2 2 0 YlqD protein CENP-Q PF13094.1 KII61612.1 - 7.2 6.6 20.9 39 4.2 13.8 2.7 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4200 PF13863.1 KII61612.1 - 7.6 6.4 20.9 2.4 8.0 3.4 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) DUF3847 PF12958.2 KII61612.1 - 8.3 6.2 16.4 8.9 6.1 3.7 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF3847) DUF641 PF04859.7 KII61612.1 - 8.7 6.1 13.1 11 5.7 2.4 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CNH PF00780.17 KII61613.1 - 3.7e-21 75.7 0.1 1e-20 74.3 0.1 1.7 1 0 0 1 1 1 1 CNH domain IncA PF04156.9 KII61613.1 - 0.0077 15.8 19.8 0.0077 15.8 13.7 4.2 1 1 2 4 4 4 2 IncA protein Prok-RING_1 PF14446.1 KII61613.1 - 0.029 14.1 4.7 0.082 12.6 3.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DUF4206 PF13901.1 KII61613.1 - 0.26 10.8 12.0 0.022 14.3 2.7 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4206) C1_1 PF00130.17 KII61613.1 - 0.64 9.7 13.7 0.24 11.1 7.1 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.1 KII61613.1 - 0.64 9.8 13.3 0.04 13.7 4.3 2.7 2 0 0 2 2 2 0 Ring finger domain DUF2259 PF10016.4 KII61615.1 - 0.087 12.5 0.2 3.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Predicted secreted protein (DUF2259) CLU_N PF15044.1 KII61615.1 - 0.21 11.7 0.3 0.21 11.7 0.2 3.1 4 0 0 4 4 4 0 Mitochondrial function, CLU-N-term DUF1132 PF06575.7 KII61615.1 - 0.52 10.6 7.6 0.26 11.6 2.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1132) TruD PF01142.13 KII61616.1 - 0.065 11.8 0.1 0.085 11.5 0.1 1.2 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) DDE_3 PF13358.1 KII61617.1 - 7.8e-09 35.4 0.2 7.5e-07 28.9 0.2 2.3 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII61617.1 - 0.0036 16.8 0.0 0.0069 15.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII61617.1 - 0.021 14.8 0.0 0.046 13.7 0.0 1.7 1 1 0 1 1 1 0 Transposase B5 PF03484.10 KII61617.1 - 0.032 14.0 0.0 0.067 13.0 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetase B5 domain PAP2_C PF14360.1 KII61618.1 - 2.6e-22 78.8 12.2 3.5e-22 78.4 8.5 1.2 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PAP2_3 PF14378.1 KII61618.1 - 0.00031 20.3 2.4 0.00042 19.8 1.6 1.2 1 0 0 1 1 1 1 PAP2 superfamily PAP2 PF01569.16 KII61618.1 - 0.0021 17.7 2.9 0.0026 17.4 2.0 1.1 1 0 0 1 1 1 1 PAP2 superfamily PyrI_C PF02748.10 KII61620.1 - 0.016 14.6 0.6 1.3 8.4 0.1 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DDE_Tnp_IS1595 PF12762.2 KII61621.1 - 3.5e-15 56.1 0.0 1.5e-14 54.1 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain zf-C2H2_7 PF15269.1 KII61622.1 - 0.094 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger MH1 PF03165.11 KII61623.1 - 4.5e-14 52.3 0.6 6e-14 51.8 0.4 1.2 1 0 0 1 1 1 1 MH1 domain UPF0147 PF03685.8 KII61625.1 - 0.0024 17.7 0.2 0.012 15.4 0.1 1.9 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0147) DUF4371 PF14291.1 KII61625.1 - 0.0071 15.9 0.2 0.0075 15.8 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) PerB PF06590.6 KII61625.1 - 0.029 14.6 0.1 0.032 14.5 0.1 1.2 1 0 0 1 1 1 0 PerB protein PGK PF00162.14 KII61627.1 - 2.9e-140 467.1 0.1 3.4e-140 466.9 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DDE_Tnp_IS1595 PF12762.2 KII61628.1 - 0.038 13.8 0.1 0.52 10.1 0.0 2.0 1 1 0 1 1 1 0 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII61630.1 - 2.1e-09 37.3 0.3 3.2e-08 33.5 0.0 2.0 1 1 1 2 2 2 1 ISXO2-like transposase domain DUF3722 PF12519.3 KII61630.1 - 0.0061 15.8 0.0 0.0066 15.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) FLYWCH PF04500.11 KII61632.1 - 8.2e-16 57.6 2.9 2.1e-15 56.3 2.0 1.7 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 KII61632.1 - 4.4e-11 42.7 0.1 3.4e-09 36.7 0.1 2.5 2 0 0 2 2 2 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.12 KII61632.1 - 0.0094 15.5 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Transposase EMA PF02488.10 KII61632.1 - 0.077 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Merozoite Antigen Zn_ribbon_recom PF13408.1 KII61632.1 - 0.24 11.6 6.4 0.53 10.5 4.4 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain rve PF00665.21 KII61633.1 - 1.4e-29 102.6 0.0 3.1e-29 101.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII61633.1 - 1e-25 90.4 0.1 2.2e-25 89.2 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII61633.1 - 7.8e-06 25.7 0.1 2.1e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII61633.1 - 1.1e-05 24.9 0.0 3.8e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.18 KII61633.1 - 6.5e-05 22.6 10.1 0.015 15.2 1.6 2.8 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII61633.1 - 0.00091 19.6 0.0 0.0024 18.3 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII61633.1 - 0.00094 18.9 0.0 0.0021 17.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.1 KII61633.1 - 0.0015 18.0 0.0 0.0062 16.0 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.6 KII61633.1 - 0.0022 17.9 0.4 0.0055 16.6 0.3 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII61633.1 - 0.013 15.2 1.4 0.013 15.2 1.0 2.8 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.1 KII61633.1 - 0.33 10.6 14.1 0.11 12.1 1.9 2.7 2 0 0 2 2 2 0 Zinc knuckle Cluap1 PF10234.4 KII61634.1 - 0.046 12.9 0.0 0.049 12.8 0.0 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 RVT_1 PF00078.22 KII61636.1 - 1.1e-19 70.6 0.0 2.3e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII61636.1 - 0.0011 18.9 0.0 0.0025 17.7 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII61636.1 - 0.017 15.5 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII61636.1 - 0.041 13.7 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease P2X_receptor PF00864.14 KII61639.1 - 0.081 11.6 0.0 0.098 11.3 0.0 1.1 1 0 0 1 1 1 0 ATP P2X receptor Serpin PF00079.15 KII61640.1 - 8.7e-21 74.4 1.3 1.2e-16 60.8 0.0 2.0 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) Serpin PF00079.15 KII61641.1 - 1.2e-48 166.1 1.8 1.4e-48 165.9 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_Tnp_IS1595 PF12762.2 KII61643.1 - 1e-13 51.3 0.0 1.4e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Wx5_PLAF3D7 PF09688.5 KII61644.1 - 0.0032 17.4 0.3 0.0079 16.1 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (Wx5_PLAF3D7) Ribosomal_L22e PF01776.12 KII61644.1 - 0.014 15.3 0.0 0.032 14.2 0.0 1.5 1 1 0 1 1 1 0 Ribosomal L22e protein family Med5 PF08689.5 KII61644.1 - 0.02 12.6 0.6 0.025 12.2 0.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit Med5 ATG16 PF08614.6 KII61644.1 - 0.036 13.8 0.6 0.067 13.0 0.0 1.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF479 PF04336.7 KII61644.1 - 0.12 12.4 0.5 3.4 7.8 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function, DUF479 OATP PF03137.15 KII61645.1 - 3.6e-73 246.4 33.5 3.8e-71 239.7 23.2 2.6 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII61645.1 - 8.3e-19 67.5 34.4 3.6e-17 62.1 20.3 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF872 PF05915.7 KII61645.1 - 0.14 11.9 7.7 3.9 7.3 0.4 3.9 4 0 0 4 4 4 0 Eukaryotic protein of unknown function (DUF872) Mtp PF03821.11 KII61647.1 - 0.33 10.3 12.4 3.6 6.9 8.6 2.0 1 1 0 1 1 1 0 Golgi 4-transmembrane spanning transporter DnaB_C PF03796.10 KII61650.1 - 0.059 12.2 0.0 0.079 11.8 0.0 1.1 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Sec23_trunk PF04811.10 KII61651.1 - 6.5e-34 117.3 0.0 9.1e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.10 KII61651.1 - 2.1e-10 40.0 3.5 4.1e-10 39.0 1.3 2.3 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger LicD PF04991.8 KII61651.1 - 0.005 16.9 0.6 0.013 15.5 0.4 1.6 1 0 0 1 1 1 1 LicD family Gelsolin PF00626.17 KII61652.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Gelsolin repeat CPSF100_C PF13299.1 KII61653.1 - 3.3e-20 72.8 0.1 7.7e-19 68.4 0.1 2.4 1 1 1 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 KII61653.1 - 2.7e-12 46.7 0.2 7.5e-10 38.8 0.0 3.1 2 1 0 2 2 2 2 Beta-Casp domain DDE_Tnp_IS1595 PF12762.2 KII61654.1 - 8.6e-14 51.6 0.0 1e-13 51.3 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain RRM_1 PF00076.17 KII61655.1 - 7e-21 73.6 0.1 4.1e-13 48.7 0.0 3.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII61655.1 - 2.6e-15 56.1 0.1 3.7e-08 33.2 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SPOC PF07744.8 KII61655.1 - 5.3e-11 43.0 0.0 1.3e-10 41.7 0.0 1.7 1 0 0 1 1 1 1 SPOC domain RRM_5 PF13893.1 KII61655.1 - 4.6e-07 29.5 0.1 0.00011 22.0 0.0 3.3 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ProSAAS PF07259.7 KII61655.1 - 0.019 14.5 0.7 0.019 14.5 0.5 1.6 2 0 0 2 2 2 0 ProSAAS precursor Cullin PF00888.17 KII61656.1 - 4.6e-10 38.6 1.9 5.1e-10 38.5 1.3 1.2 1 0 0 1 1 1 1 Cullin family Y1_Tnp PF01797.11 KII61658.1 - 0.14 12.0 0.4 0.42 10.4 0.1 1.8 1 1 0 2 2 2 0 Transposase IS200 like Pro_isomerase PF00160.16 KII61660.1 - 2.1e-34 118.9 0.1 3.9e-34 118.1 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Vfa1 PF08432.5 KII61660.1 - 0.0046 17.0 0.4 0.0046 17.0 0.3 1.6 2 0 0 2 2 2 1 AAA-ATPase Vps4-associated protein 1 La PF05383.12 KII61663.1 - 0.0011 18.6 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 La domain DUF4371 PF14291.1 KII61666.1 - 0.15 11.6 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) Mito_carr PF00153.22 KII61667.1 - 3.4e-51 170.9 0.0 5.9e-21 73.9 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Ammonium_transp PF00909.16 KII61667.1 - 0.011 14.2 0.2 0.58 8.5 0.1 2.1 2 0 0 2 2 2 0 Ammonium Transporter Family Antimicrobial20 PF08256.6 KII61667.1 - 0.034 14.4 0.8 0.29 11.5 0.0 3.0 3 0 0 3 3 3 0 Aurein-like antibiotic peptide DUF1992 PF09350.5 KII61670.1 - 0.094 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1992) DDE_3 PF13358.1 KII61671.1 - 0.00079 19.1 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3403 PF11883.3 KII61671.1 - 0.087 13.1 0.2 0.46 10.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3403) YmgB PF10798.3 KII61672.1 - 0.042 13.6 0.2 0.08 12.7 0.1 1.4 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR Fe_dep_repr_C PF02742.10 KII61672.1 - 0.059 13.0 0.2 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain Latexin PF06907.7 KII61673.1 - 0.0022 17.1 0.0 0.0028 16.8 0.0 1.1 1 0 0 1 1 1 1 Latexin DUF3328 PF11807.3 KII61675.1 - 0.062 12.9 0.3 0.11 12.1 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) Ilm1 PF10311.4 KII61675.1 - 0.067 12.6 0.2 0.095 12.2 0.2 1.3 1 1 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 BNR PF02012.15 KII61676.1 - 0.0014 18.1 2.6 3 8.0 0.0 4.0 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF2624 PF11116.3 KII61676.1 - 0.11 12.9 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) Serpin PF00079.15 KII61677.1 - 6.1e-48 163.8 1.4 6.9e-48 163.6 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Lactococcin_972 PF09683.5 KII61677.1 - 0.099 13.0 0.6 5.7 7.3 0.0 2.4 2 0 0 2 2 2 0 Bacteriocin (Lactococcin_972) Serpin PF00079.15 KII61678.1 - 1.4e-40 139.5 1.0 6.5e-36 124.2 0.4 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) Septin PF00735.13 KII61679.1 - 4.1e-54 183.4 0.1 4.7e-54 183.3 0.1 1.0 1 0 0 1 1 1 1 Septin Serpin PF00079.15 KII61680.1 - 3.4e-13 49.4 0.2 4.3e-13 49.1 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-NPL4 PF05020.10 KII61680.1 - 0.025 14.2 0.1 0.048 13.3 0.0 1.5 1 1 0 1 1 1 0 NPL4 family, putative zinc binding region Serpin PF00079.15 KII61681.1 - 2.2e-39 135.6 3.4 2.7e-39 135.3 2.3 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII61682.1 - 4.3e-17 62.3 2.4 4.7e-17 62.1 1.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII61684.1 - 5.6e-36 124.4 0.0 6.9e-36 124.1 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) UQ_con PF00179.21 KII61687.1 - 9.9e-18 63.9 0.5 8.8e-17 60.8 0.3 1.9 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Ala_racemase_N PF01168.15 KII61688.1 - 1.9e-07 30.8 0.0 4.7e-06 26.3 0.0 2.1 1 1 1 2 2 2 1 Alanine racemase, N-terminal domain DDE_3 PF13358.1 KII61688.1 - 5.4e-07 29.4 0.0 9.8e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2296 PF10058.4 KII61688.1 - 0.01 15.5 1.6 15 5.4 0.1 3.3 3 0 0 3 3 3 0 Predicted integral membrane metal-binding protein (DUF2296) THP2 PF09432.5 KII61689.1 - 0.042 13.7 0.1 0.11 12.3 0.1 1.6 1 1 0 1 1 1 0 Tho complex subunit THP2 DUF732 PF05305.9 KII61689.1 - 0.062 13.3 0.0 0.08 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF732) Myotub-related PF06602.9 KII61690.1 - 0.0013 17.6 0.3 0.0022 16.8 0.1 1.4 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain HTH_33 PF13592.1 KII61693.1 - 7.4e-05 22.2 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_29 PF13551.1 KII61693.1 - 0.0003 20.9 0.1 0.06 13.4 0.0 3.0 2 1 0 2 2 2 1 Winged helix-turn helix MarR_2 PF12802.2 KII61693.1 - 0.00045 19.8 0.2 0.15 11.7 0.0 2.7 3 0 0 3 3 3 1 MarR family ComX PF05952.7 KII61693.1 - 0.00067 19.1 0.1 0.15 11.6 0.0 2.4 2 0 0 2 2 2 1 Bacillus competence pheromone ComX PAX PF00292.13 KII61693.1 - 0.00095 18.8 0.1 0.0021 17.7 0.0 1.6 2 0 0 2 2 2 1 'Paired box' domain TrmB PF01978.14 KII61693.1 - 0.0073 15.9 0.0 3.6 7.3 0.0 2.4 2 0 0 2 2 2 2 Sugar-specific transcriptional regulator TrmB HTH_Tnp_Tc3_2 PF01498.13 KII61693.1 - 0.016 15.2 0.1 37 4.4 0.0 3.9 4 0 0 4 4 4 0 Transposase HTH_28 PF13518.1 KII61693.1 - 0.016 15.1 0.0 9.2 6.3 0.0 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_23 PF13384.1 KII61693.1 - 0.021 14.5 0.0 1.3 8.7 0.0 3.2 3 0 0 3 3 3 0 Homeodomain-like domain HTH_24 PF13412.1 KII61693.1 - 0.028 13.7 0.0 0.38 10.1 0.0 2.4 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF1974 PF09317.6 KII61693.1 - 0.065 12.6 0.0 0.11 11.8 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1974) SlyX PF04102.7 KII61693.1 - 0.24 11.7 2.3 15 6.0 0.0 2.5 2 0 0 2 2 2 0 SlyX Band_7 PF01145.20 KII61694.1 - 2.2e-08 34.2 0.1 2.5e-08 34.0 0.1 1.0 1 0 0 1 1 1 1 SPFH domain / Band 7 family Mesothelin PF06060.7 KII61698.1 - 0.089 10.8 0.0 0.11 10.5 0.0 1.1 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Proteasome PF00227.21 KII61699.1 - 5.6e-34 117.0 0.0 7.4e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit ATP-synt_ab PF00006.20 KII61700.1 - 3.3e-56 190.1 0.1 4.4e-56 189.7 0.1 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.18 KII61700.1 - 2.7e-11 43.5 0.2 5.7e-11 42.4 0.1 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Rtf2 PF04641.7 KII61700.1 - 0.22 10.7 0.0 0.32 10.1 0.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger PAS PF00989.19 KII61701.1 - 0.0011 18.7 0.0 0.0036 17.0 0.0 1.8 1 1 0 1 1 1 1 PAS fold PAS_9 PF13426.1 KII61701.1 - 0.0037 17.6 0.0 0.0057 17.0 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_2 PF08446.6 KII61701.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.6 1 1 1 2 2 2 0 PAS fold Acetyltransf_CG PF14542.1 KII61702.1 - 0.05 13.4 1.4 0.093 12.6 0.2 1.9 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase IncA PF04156.9 KII61703.1 - 0.058 12.9 0.2 0.15 11.6 0.2 1.8 1 1 0 1 1 1 0 IncA protein NPV_P10 PF05531.7 KII61703.1 - 0.081 13.1 1.6 7 6.9 0.0 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein EF-hand_5 PF13202.1 KII61704.1 - 0.092 12.1 0.2 0.46 9.9 0.1 2.2 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.1 KII61704.1 - 0.12 12.3 0.6 6.5 6.9 0.0 3.5 3 1 1 4 4 4 0 EF-hand domain EF-hand_7 PF13499.1 KII61704.1 - 0.23 11.6 3.5 14 5.9 0.3 2.6 1 1 0 2 2 2 0 EF-hand domain pair 2OG-FeII_Oxy_3 PF13640.1 KII61705.1 - 0.0023 18.3 0.0 0.011 16.2 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DDE_3 PF13358.1 KII61706.1 - 3.8e-15 55.8 0.0 5.4e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII61706.1 - 0.0086 16.1 0.0 0.028 14.5 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain RDD PF06271.7 KII61708.1 - 9.1e-07 28.8 12.4 4e-06 26.7 8.6 1.8 1 1 0 1 1 1 1 RDD family DDE_3 PF13358.1 KII61709.1 - 0.00028 20.6 0.0 0.00046 19.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DAG_kinase_N PF14513.1 KII61713.1 - 0.095 12.9 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus DEAD PF00270.24 KII61717.1 - 2.7e-44 150.6 0.0 6.7e-44 149.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII61717.1 - 1.2e-24 85.9 0.1 3.5e-24 84.4 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII61717.1 - 0.0074 16.1 0.0 0.021 14.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KII61718.1 - 5.4e-65 219.1 0.0 1.1e-64 218.1 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 KII61718.1 - 1.5e-18 66.1 2.4 4.6e-09 35.8 0.1 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 KII61718.1 - 1.8e-14 53.3 0.0 4.7e-14 51.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII61718.1 - 7.2e-07 29.2 0.0 2.1e-05 24.4 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RE_EcoO109I PF14511.1 KII61719.1 - 0.22 10.9 2.6 0.36 10.2 0.6 1.9 1 1 1 2 2 2 0 Type II restriction endonuclease EcoO109I DDE_3 PF13358.1 KII61720.1 - 1.5e-20 73.4 0.0 1.7e-20 73.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Fer4_12 PF13353.1 KII61720.1 - 0.01 15.9 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain DDE_1 PF03184.14 KII61720.1 - 0.055 12.6 0.0 0.069 12.2 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_33 PF13592.1 KII61721.1 - 0.014 14.8 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII61721.1 - 0.016 15.2 0.1 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Transposase Arg_repressor PF01316.16 KII61721.1 - 0.028 13.9 0.2 0.51 9.9 0.1 2.1 1 1 1 2 2 2 0 Arginine repressor, DNA binding domain HTH_29 PF13551.1 KII61721.1 - 0.1 12.7 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn helix Sas10_Utp3 PF04000.10 KII61727.1 - 0.0092 16.1 0.1 0.068 13.3 0.0 2.3 2 1 0 2 2 2 1 Sas10/Utp3/C1D family ARHGEF5_35 PF15441.1 KII61727.1 - 0.12 11.1 1.8 0.15 10.8 1.3 1.1 1 0 0 1 1 1 0 Rho guanine nucleotide exchange factor 5/35 TCP PF03634.8 KII61727.1 - 0.24 11.7 5.8 4.9 7.5 4.0 2.2 1 1 0 1 1 1 0 TCP family transcription factor Acyltransferase PF01553.16 KII61728.1 - 3.4e-17 62.1 0.1 6.3e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Citrate_synt PF00285.16 KII61730.1 - 4.6e-89 298.6 0.0 5.4e-89 298.4 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase MRP-S22 PF10245.4 KII61731.1 - 4e-36 124.6 0.3 5.3e-36 124.2 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S22 MFS_1 PF07690.11 KII61732.1 - 8.9e-10 37.8 18.8 1e-09 37.5 13.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF998 PF06197.8 KII61732.1 - 1.5 8.1 12.7 0.038 13.2 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF998) dsrm PF00035.20 KII61734.1 - 1.9e-10 41.1 0.4 8.3e-05 23.0 0.0 2.2 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.1 KII61734.1 - 0.02 15.1 0.4 2.4 8.4 0.3 2.8 2 1 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 tRNA_bind PF01588.15 KII61736.1 - 5.8e-13 48.4 0.2 9.2e-13 47.8 0.1 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain Histone PF00125.19 KII61737.1 - 2.3e-12 46.8 0.2 2.7e-12 46.6 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 KII61737.1 - 0.00024 20.9 0.1 0.00038 20.3 0.0 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 KII61737.1 - 0.0045 17.0 0.0 0.007 16.4 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.1 KII61737.1 - 0.036 14.2 0.1 0.058 13.5 0.1 1.5 1 1 0 1 1 1 0 Kinetochore component CENP-S TFIID-31kDa PF02291.10 KII61737.1 - 0.067 12.9 0.0 0.072 12.8 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit E3_binding PF02817.12 KII61737.1 - 0.17 11.5 0.7 0.44 10.2 0.3 1.9 1 1 1 2 2 2 0 e3 binding domain RICTOR_M PF14666.1 KII61741.1 - 2e-14 53.1 7.6 4.5e-14 52.0 1.0 2.7 3 0 0 3 3 3 2 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.1 KII61741.1 - 1.8e-06 27.8 0.4 8.6e-06 25.6 0.0 2.3 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.1 KII61741.1 - 0.00088 19.1 0.1 0.0046 16.8 0.0 2.1 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 Cnd1 PF12717.2 KII61741.1 - 1.7 8.4 6.9 4.1 7.1 0.3 3.2 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 ParA PF10609.4 KII61743.1 - 2.5e-25 88.1 0.1 4e-25 87.5 0.1 1.3 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 KII61743.1 - 2.8e-21 75.8 0.0 3.9e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 KII61743.1 - 2.2e-12 47.2 0.1 2.8e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.10 KII61743.1 - 7.6e-11 41.6 0.4 4.7e-07 29.1 0.3 3.0 3 0 0 3 3 3 2 Anion-transporting ATPase MipZ PF09140.6 KII61743.1 - 2.8e-08 33.1 0.0 5.4e-08 32.2 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ SRP54 PF00448.17 KII61743.1 - 0.0011 18.5 0.2 0.012 15.1 0.0 2.1 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_NifH PF00142.13 KII61743.1 - 0.0017 17.6 0.1 0.0037 16.4 0.0 1.5 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_26 PF13500.1 KII61743.1 - 0.0029 17.2 0.1 1.7 8.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain ArgK PF03308.11 KII61743.1 - 0.0077 15.0 0.1 0.011 14.5 0.1 1.2 1 0 0 1 1 1 1 ArgK protein APS_kinase PF01583.15 KII61743.1 - 0.017 14.7 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase MobB PF03205.9 KII61743.1 - 0.038 13.6 0.1 0.061 13.0 0.1 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B VirC1 PF07015.6 KII61743.1 - 0.061 12.3 0.1 0.093 11.7 0.0 1.2 1 0 0 1 1 1 0 VirC1 protein KTI12 PF08433.5 KII61743.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 CBF PF03914.12 KII61744.1 - 5.6e-24 84.4 0.9 9.8e-24 83.6 0.1 1.8 2 0 0 2 2 2 1 CBF/Mak21 family AhpC-TSA PF00578.16 KII61746.1 - 6.5e-42 142.1 0.0 9e-42 141.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KII61746.1 - 1.3e-17 63.7 0.0 1.8e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 KII61746.1 - 6.3e-10 38.5 0.0 1.2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin MFS_1 PF07690.11 KII61747.1 - 1.5e-09 37.0 47.6 4.7e-09 35.4 24.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_M50 PF02163.17 KII61747.1 - 3.5 6.5 10.6 16 4.3 6.3 2.8 1 1 0 1 1 1 0 Peptidase family M50 Aldo_ket_red PF00248.16 KII61748.1 - 2.1e-26 92.4 0.0 2.4e-26 92.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Cation_efflux PF01545.16 KII61749.1 - 1.5e-49 168.5 6.8 1.9e-49 168.3 4.7 1.0 1 0 0 1 1 1 1 Cation efflux family HMG_box PF00505.14 KII61750.1 - 3.4e-13 49.6 2.4 1.5e-12 47.5 0.3 2.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KII61750.1 - 1.1e-11 44.8 1.7 3.7e-11 43.2 0.1 2.6 2 0 0 2 2 2 1 HMG-box domain DUF740 PF05340.7 KII61750.1 - 0.012 13.9 0.7 0.015 13.6 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Myb_DNA-bind_4 PF13837.1 KII61750.1 - 0.03 14.4 1.7 0.15 12.2 0.1 2.6 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain CCDC-167 PF15188.1 KII61750.1 - 0.071 13.0 1.1 6.2 6.8 0.1 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF3119 PF11317.3 KII61751.1 - 0.13 12.3 0.4 0.3 11.1 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) UCH PF00443.24 KII61752.1 - 6.7e-47 159.8 0.7 1.3e-46 158.9 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KII61752.1 - 8.1e-28 97.6 0.0 1.4e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.3 KII61752.1 - 1.5e-11 44.0 3.1 6.4e-09 35.4 2.5 2.2 1 1 0 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 KII61753.1 - 1e-06 28.3 0.5 1.8e-06 27.5 0.1 1.5 1 1 1 2 2 2 1 Ubiquitin-specific protease C-terminal AKAP7_NLS PF10469.4 KII61754.1 - 0.015 14.9 0.2 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 AKAP7 2'5' RNA ligase-like domain KH_3 PF13014.1 KII61754.1 - 0.079 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 KH domain AKAP7_NLS PF10469.4 KII61755.1 - 7.6e-41 140.1 0.2 8.4e-41 139.9 0.1 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.1 KII61755.1 - 1.2e-09 38.0 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily GSH-S_ATP PF02955.11 KII61755.1 - 0.0019 17.3 0.0 0.0029 16.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain DUF2365 PF10157.4 KII61755.1 - 0.012 15.4 0.1 0.22 11.4 0.0 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2365) DUF3810 PF12725.2 KII61755.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) UAA PF08449.6 KII61756.1 - 2.9e-86 289.1 25.5 3.4e-86 288.9 17.7 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KII61756.1 - 1.1e-10 41.3 7.6 1.1e-10 41.3 5.3 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KII61756.1 - 0.0046 16.9 6.5 0.0046 16.9 4.5 4.2 1 1 3 4 4 4 3 EamA-like transporter family CK_II_beta PF01214.13 KII61757.1 - 2.5e-46 157.4 0.9 3.1e-46 157.2 0.6 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CK_II_beta PF01214.13 KII61758.1 - 7.1e-48 162.5 0.0 8.5e-48 162.2 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit zf-C2H2_jaz PF12171.3 KII61758.1 - 0.12 12.5 0.2 0.12 12.5 0.1 2.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DDE_Tnp_IS1595 PF12762.2 KII61759.1 - 4.1e-08 33.1 0.0 1.1e-07 31.8 0.0 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain Elongin_A PF06881.6 KII61759.1 - 0.14 12.5 1.1 0.31 11.4 0.8 1.7 1 1 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A RVT_1 PF00078.22 KII61761.1 - 3.3e-26 91.9 0.0 7.5e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII61761.1 - 5.9e-23 81.2 0.1 1.6e-21 76.6 0.0 3.2 4 0 0 4 4 3 1 Integrase core domain RVP PF00077.15 KII61761.1 - 2.3e-07 30.6 0.1 6.2e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII61761.1 - 1.3e-06 28.7 0.0 3.3e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease Retrotrans_gag PF03732.12 KII61761.1 - 2.6e-05 24.1 0.0 0.00037 20.5 0.0 2.6 2 0 0 2 2 2 1 Retrotransposon gag protein RVP_2 PF08284.6 KII61761.1 - 0.00077 19.4 0.0 0.0018 18.2 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII61761.1 - 0.002 17.9 3.4 0.002 17.9 2.4 2.4 2 0 0 2 2 2 1 Zinc knuckle Asp_protease PF09668.5 KII61761.1 - 0.0062 16.1 0.3 0.012 15.1 0.2 1.4 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A3 PF02160.10 KII61761.1 - 0.0076 15.8 0.3 0.019 14.5 0.2 1.7 1 0 0 1 1 1 1 Cauliflower mosaic virus peptidase (A3) zf-CCHC_4 PF14392.1 KII61761.1 - 0.0084 15.7 0.2 0.033 13.8 0.1 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-H2C2 PF09337.5 KII61761.1 - 0.0096 15.3 0.1 0.021 14.2 0.1 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger gag-asp_proteas PF13975.1 KII61761.1 - 0.082 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease IU_nuc_hydro PF01156.14 KII61762.1 - 8.4e-40 136.8 0.0 9.4e-40 136.7 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DDE_Tnp_IS1595 PF12762.2 KII61763.1 - 1.9e-10 40.7 0.0 2.3e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF4516 PF14990.1 KII61765.1 - 0.31 10.6 1.8 2.8 7.5 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4516) Mg296 PF09644.5 KII61766.1 - 0.24 11.2 1.4 2.5 7.9 0.0 2.4 1 1 1 2 2 2 0 Mg296 protein NPL4 PF05021.10 KII61767.1 - 6.2e-91 304.7 0.0 7.9e-91 304.3 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 KII61767.1 - 7e-36 123.0 3.0 7e-36 123.0 2.1 2.2 2 0 0 2 2 2 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 KII61767.1 - 0.00092 19.4 0.0 0.0021 18.2 0.0 1.6 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 ESCRT-II PF05871.7 KII61768.1 - 0.084 12.7 0.9 0.11 12.4 0.7 1.1 1 0 0 1 1 1 0 ESCRT-II complex subunit RloB PF13707.1 KII61769.1 - 0.042 13.5 0.7 0.053 13.1 0.5 1.2 1 0 0 1 1 1 0 RloB-like protein eRF1_3 PF03465.10 KII61769.1 - 0.074 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 eRF1 domain 3 Motile_Sperm PF00635.21 KII61775.1 - 3.9e-15 55.4 1.2 7.3e-15 54.5 0.8 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CCSMST1 PF15013.1 KII61775.1 - 0.02 14.8 0.2 0.046 13.6 0.1 1.7 1 0 0 1 1 1 0 CCSMST1 family Big_2 PF02368.13 KII61775.1 - 0.042 13.7 0.3 0.065 13.1 0.2 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) PapD_N PF00345.15 KII61775.1 - 0.042 13.6 0.2 0.11 12.3 0.2 1.7 1 1 0 1 1 1 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain DDE_3 PF13358.1 KII61776.1 - 0.0046 16.6 0.1 0.0076 16.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII61777.1 - 1.3e-23 83.3 0.0 2.8e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII61777.1 - 5.2e-15 55.3 0.0 1.3e-14 54.0 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII61777.1 - 0.0012 18.3 0.0 0.0031 16.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII61777.1 - 0.037 14.0 0.0 0.099 12.6 0.0 1.7 1 0 0 1 1 1 0 DDE domain RVP PF00077.15 KII61778.1 - 0.00017 21.4 0.0 0.00042 20.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII61778.1 - 0.0046 16.7 0.0 0.0073 16.0 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII61778.1 - 0.0062 16.4 13.6 0.023 14.6 0.7 2.6 2 0 0 2 2 2 2 Zinc knuckle Retrotrans_gag PF03732.12 KII61778.1 - 0.1 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein eIF3g PF12353.3 KII61778.1 - 0.79 9.6 4.9 0.21 11.5 1.1 1.7 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_4 PF14392.1 KII61778.1 - 4.2 7.1 11.4 1.1 8.9 0.7 2.7 2 0 0 2 2 2 0 Zinc knuckle PC_rep PF01851.17 KII61779.1 - 0.063 13.5 2.2 6.9 7.1 0.0 4.1 5 0 0 5 5 5 0 Proteasome/cyclosome repeat APC10 PF03256.11 KII61780.1 - 3e-30 105.2 0.0 3.3e-30 105.1 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Tetraspannin PF00335.15 KII61783.1 - 8.7e-11 41.5 17.0 1.4e-10 40.8 11.8 1.3 1 1 0 1 1 1 1 Tetraspanin family Flavi_propep PF01570.12 KII61784.1 - 0.071 12.8 0.7 0.13 12.0 0.5 1.4 1 0 0 1 1 1 0 Flavivirus polyprotein propeptide AftA_N PF12250.3 KII61785.1 - 0.029 13.1 2.9 0.06 12.0 2.0 1.5 1 1 0 1 1 1 0 Arabinofuranosyltransferase N terminal DUF485 PF04341.7 KII61785.1 - 0.22 11.2 3.8 1.3 8.7 2.6 2.0 1 1 0 1 1 1 0 Protein of unknown function, DUF485 FtsX PF02687.16 KII61785.1 - 0.32 10.7 8.3 0.065 12.9 3.3 1.6 1 1 0 1 1 1 0 FtsX-like permease family OB_RNB PF08206.6 KII61786.1 - 0.057 12.9 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain FixG_C PF11614.3 KII61786.1 - 0.08 13.0 0.2 1 9.5 0.1 2.3 2 1 0 2 2 2 0 IG-like fold at C-terminal of FixG, putative oxidoreductase ARPC4 PF05856.7 KII61786.1 - 0.083 12.2 2.1 0.28 10.5 0.2 2.0 1 1 1 2 2 2 0 ARP2/3 complex 20 kDa subunit (ARPC4) Cupredoxin_1 PF13473.1 KII61787.1 - 0.016 15.0 0.1 0.035 13.9 0.1 1.5 1 0 0 1 1 1 0 Cupredoxin-like domain Peptidase_A8 PF01252.13 KII61789.1 - 0.032 13.8 0.2 0.048 13.2 0.1 1.2 1 0 0 1 1 1 0 Signal peptidase (SPase) II Paramyxo_C PF01692.13 KII61789.1 - 0.26 10.8 6.3 0.068 12.7 1.6 1.8 1 1 1 2 2 2 0 Paramyxovirus non-structural protein c DUF3674 PF12426.3 KII61791.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 RNA dependent RNA polymerase Tnp_zf-ribbon_2 PF13842.1 KII61792.1 - 0.1 12.9 0.9 0.29 11.5 0.6 1.8 1 1 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon RVT_1 PF00078.22 KII61794.1 - 0.09 12.1 0.1 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.9 KII61794.1 - 0.097 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) DUF2417 PF10329.4 KII61795.1 - 0.054 12.9 0.0 0.07 12.5 0.0 1.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) UvrD_C PF13361.1 KII61796.1 - 2.3e-38 132.5 0.5 2.7e-38 132.3 0.3 1.1 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 KII61796.1 - 8.2e-11 41.9 0.0 1.5e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 KII61796.1 - 0.01 15.3 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Exonuc_V_gamma PF04257.9 KII61796.1 - 0.012 13.6 0.0 0.015 13.3 0.0 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit EAL PF00563.15 KII61797.1 - 2.6e-66 223.4 0.3 7.2e-66 222.0 0.3 1.6 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.16 KII61797.1 - 1.5e-42 144.8 0.2 2.9e-42 143.9 0.1 1.5 1 0 0 1 1 1 1 GGDEF domain Resolvase PF00239.16 KII61797.1 - 0.096 12.5 0.0 1.7 8.4 0.0 2.7 2 1 1 3 3 3 0 Resolvase, N terminal domain O-antigen_lig PF13425.1 KII61798.1 - 9e-23 80.8 1.1 9e-23 80.8 0.7 3.5 2 1 0 3 3 3 1 O-antigen ligase like membrane protein Wzy_C PF04932.10 KII61798.1 - 3.3e-17 62.7 0.3 3.3e-17 62.7 0.2 2.6 1 1 0 2 2 2 1 O-Antigen ligase DUF4131 PF13567.1 KII61798.1 - 2.1 7.7 31.7 0.19 11.1 0.5 4.6 2 1 3 5 5 5 0 Domain of unknown function (DUF4131) Glycos_transf_2 PF00535.21 KII61799.1 - 6.4e-20 71.5 0.2 1.2e-19 70.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII61799.1 - 1.7e-09 37.8 0.0 2.4e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KII61799.1 - 1.4e-08 34.6 0.0 1.9e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_2 PF10111.4 KII61799.1 - 7.8e-07 28.4 7.6 2.9e-06 26.6 5.3 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.9 KII61799.1 - 8.5e-05 21.9 0.1 0.00016 21.1 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase zf-U11-48K PF05253.7 KII61800.1 - 2e-09 36.9 6.1 9.3e-07 28.4 0.2 3.0 3 0 0 3 3 3 2 U11-48K-like CHHC zinc finger dsrm PF00035.20 KII61800.1 - 0.00033 21.1 0.1 0.00069 20.1 0.1 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Phage_XkdX PF09693.5 KII61802.1 - 0.14 11.6 0.6 0.31 10.5 0.1 1.8 2 0 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) uDENN PF03456.13 KII61806.1 - 0.049 13.6 0.9 0.66 9.9 0.0 2.8 3 0 0 3 3 3 0 uDENN domain PIF1 PF05970.9 KII61807.1 - 1.7e-26 93.0 0.4 1.9e-26 92.9 0.3 1.1 1 0 0 1 1 1 1 PIF1-like helicase RVT_1 PF00078.22 KII61807.1 - 0.017 14.4 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Rifin_STEVOR PF02009.11 KII61808.1 - 0.00011 21.9 6.2 0.00015 21.5 4.3 1.1 1 0 0 1 1 1 1 Rifin/stevor family DUF912 PF06024.7 KII61808.1 - 0.0022 17.9 0.5 0.0041 17.1 0.4 1.6 1 1 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4448 PF14610.1 KII61808.1 - 0.013 14.9 0.5 0.02 14.4 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) 60KD_IMP PF02096.15 KII61808.1 - 0.023 14.3 1.7 0.031 13.9 1.2 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein Vma12 PF11712.3 KII61808.1 - 0.029 14.0 2.7 0.046 13.4 1.9 1.5 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF3464 PF11947.3 KII61808.1 - 0.052 13.0 2.3 0.077 12.4 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) AMA-1 PF02430.10 KII61808.1 - 0.057 12.2 1.2 0.069 12.0 0.8 1.0 1 0 0 1 1 1 0 Apical membrane antigen 1 TMEM192 PF14802.1 KII61808.1 - 0.058 12.2 0.5 0.079 11.8 0.3 1.2 1 0 0 1 1 1 0 TMEM192 family Viral_Beta_CD PF04530.7 KII61808.1 - 0.059 13.5 0.2 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Viral Beta C/D like family AJAP1_PANP_C PF15298.1 KII61808.1 - 0.074 12.9 25.5 0.1 12.4 17.7 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF3139 PF11337.3 KII61808.1 - 0.21 11.9 2.3 0.38 11.0 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Plasmodium_Vir PF05795.6 KII61808.1 - 0.32 10.1 1.9 0.39 9.8 1.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Pex14_N PF04695.8 KII61808.1 - 0.54 10.3 4.9 1.1 9.2 3.4 1.6 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Jacalin PF01419.12 KII61809.1 - 0.065 13.1 0.2 0.097 12.5 0.1 1.3 1 1 0 1 1 1 0 Jacalin-like lectin domain DUF3942 PF13078.1 KII61809.1 - 0.082 13.0 2.4 0.11 12.6 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3942) DUF3990 PF13151.1 KII61810.1 - 0.054 12.8 0.2 0.072 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) WD40 PF00400.27 KII61811.1 - 1.3e-12 47.1 12.2 4.7e-10 38.9 0.1 5.9 7 0 0 7 7 7 2 WD domain, G-beta repeat TFIID_30kDa PF03540.8 KII61812.1 - 6.9e-15 54.6 0.0 1.1e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Ribosomal_60s PF00428.14 KII61812.1 - 0.13 12.7 0.2 0.41 11.0 0.0 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein Lactamase_B PF00753.22 KII61813.1 - 3.6e-08 33.2 0.0 4.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KII61813.1 - 0.0013 18.2 0.0 0.0015 18.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PDEase_II PF02112.10 KII61813.1 - 0.0081 15.1 0.1 0.0091 14.9 0.0 1.2 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II DNA_ligase_ZBD PF03119.11 KII61814.1 - 0.079 12.6 0.1 0.18 11.5 0.1 1.7 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Hexokinase_2 PF03727.11 KII61817.1 - 4.3e-29 101.4 0.3 5.9e-29 100.9 0.2 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII61817.1 - 7.4e-29 100.5 0.1 1e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 KII61818.1 - 2.4e-31 108.7 0.3 3e-31 108.4 0.2 1.0 1 0 0 1 1 1 1 Hexokinase DUF3037 PF11236.3 KII61820.1 - 0.047 13.7 0.0 0.085 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) Sec5 PF15469.1 KII61820.1 - 0.51 10.0 5.3 0.31 10.7 2.0 1.7 2 0 0 2 2 2 0 Exocyst complex component Sec5 DDE_3 PF13358.1 KII61821.1 - 4.8e-09 36.1 0.0 8.1e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_IS630 PF01710.11 KII61821.1 - 3.9e-06 26.5 0.1 6.4e-06 25.8 0.1 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.1 KII61821.1 - 3.8e-05 23.1 0.0 0.00057 19.4 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII61821.1 - 4.9e-05 23.2 0.0 0.00019 21.3 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.1 KII61821.1 - 0.0037 18.0 0.0 0.0093 16.7 0.1 1.7 2 0 0 2 2 1 1 Homeodomain-like domain HTH_29 PF13551.1 KII61821.1 - 0.0086 16.2 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 KII61821.1 - 0.015 15.0 0.0 0.034 13.8 0.0 1.5 2 0 0 2 2 2 0 'Paired box' domain HTH_Tnp_Tc3_2 PF01498.13 KII61821.1 - 0.022 14.8 1.7 0.044 13.8 0.5 2.0 2 0 0 2 2 2 0 Transposase LpxB PF02684.10 KII61821.1 - 0.031 12.8 0.1 0.043 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase HTH_33 PF13592.1 KII61821.1 - 0.034 13.6 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix DUF3523 PF12037.3 KII61821.1 - 0.051 12.5 1.2 0.08 11.9 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) HTH_Crp_2 PF13545.1 KII61821.1 - 0.064 13.0 0.0 4.1 7.2 0.0 2.8 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain Lactamase_B PF00753.22 KII61823.1 - 2.5e-11 43.5 0.1 2.9e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KII61823.1 - 0.002 17.6 0.1 0.0024 17.4 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CBAH PF02275.13 KII61823.1 - 0.035 13.5 0.0 0.035 13.5 0.0 1.1 1 0 0 1 1 1 0 Linear amide C-N hydrolases, choloylglycine hydrolase family Utp12 PF04003.7 KII61824.1 - 1.2e-07 31.5 0.5 1.8e-07 31.0 0.3 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family RSF PF14876.1 KII61824.1 - 0.021 13.6 0.7 0.03 13.1 0.5 1.2 1 0 0 1 1 1 0 Respiratory growth transcriptional regulator zf-CpG_bind_C PF12269.3 KII61827.1 - 0.037 13.5 0.0 0.046 13.2 0.0 1.1 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Ldl_recept_a PF00057.13 KII61830.1 - 1.1e-45 153.1 124.8 4.6e-11 42.4 6.2 7.8 7 0 0 7 7 7 7 Low-density lipoprotein receptor domain class A E1_DerP2_DerF2 PF02221.10 KII61834.1 - 2.8e-07 30.8 0.4 4.1e-07 30.3 0.3 1.1 1 0 0 1 1 1 1 ML domain rve PF00665.21 KII61838.1 - 1.6e-21 76.6 0.0 1.9e-21 76.3 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII61838.1 - 0.14 11.7 0.0 0.28 10.7 0.0 1.6 1 1 0 1 1 1 0 Integrase core domain Tetraspannin PF00335.15 KII61840.1 - 3.4e-05 23.2 7.9 3.9e-05 23.0 5.5 1.1 1 0 0 1 1 1 1 Tetraspanin family TauE PF01925.14 KII61840.1 - 0.0059 16.0 5.8 0.0079 15.6 4.0 1.3 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE QueT PF06177.6 KII61840.1 - 0.029 14.3 8.1 0.043 13.7 5.6 1.3 1 0 0 1 1 1 0 QueT transporter DUF4134 PF13572.1 KII61840.1 - 0.04 14.0 5.1 0.13 12.3 3.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4134) Arif-1 PF06770.6 KII61840.1 - 0.097 12.0 4.4 0.12 11.7 3.1 1.2 1 0 0 1 1 1 0 Actin-rearrangement-inducing factor (Arif-1) DUF4173 PF13777.1 KII61840.1 - 0.21 10.8 3.8 0.27 10.5 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) Arteri_Gl PF00951.13 KII61840.1 - 1.2 8.6 6.9 0.4 10.2 2.8 1.5 1 1 1 2 2 2 0 Arterivirus GL envelope glycoprotein YlaH PF14036.1 KII61840.1 - 8.8 6.4 10.7 0.28 11.3 2.8 1.9 2 0 0 2 2 2 0 YlaH-like protein COesterase PF00135.23 KII61841.1 - 0.0017 17.1 0.3 0.0023 16.7 0.2 1.2 1 0 0 1 1 1 1 Carboxylesterase family UBN2 PF14223.1 KII61846.1 - 7.6e-05 22.4 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type RVT_1 PF00078.22 KII61846.1 - 9.5e-05 21.8 0.0 0.00021 20.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII61846.1 - 0.00041 20.2 0.0 0.00088 19.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII61846.1 - 0.00051 19.7 12.8 0.025 14.3 1.3 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.18 KII61846.1 - 0.001 18.8 14.6 0.031 14.2 2.2 2.6 2 0 0 2 2 2 2 Zinc knuckle Peptidase_A2E PF12382.3 KII61846.1 - 0.0068 16.2 0.3 0.012 15.3 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon peptidase Asp_protease_2 PF13650.1 KII61846.1 - 0.031 14.7 0.0 0.065 13.7 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease rve PF00665.21 KII61847.1 - 6.8e-25 87.5 0.0 2e-24 85.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII61847.1 - 0.037 13.5 0.0 0.093 12.2 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Serpin PF00079.15 KII61849.1 - 2.9e-36 125.3 1.5 4.3e-36 124.8 1.1 1.2 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.21 KII61852.1 - 8.4e-25 87.2 0.0 1.5e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII61852.1 - 0.00034 20.0 0.0 0.00072 19.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain CDK2AP PF09806.4 KII61853.1 - 5.7 7.1 9.4 18 5.5 6.5 2.0 1 1 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Fig1 PF12351.3 KII61854.1 - 0.095 12.5 0.4 0.12 12.2 0.2 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Peptidase_S9 PF00326.16 KII61856.1 - 2.3e-20 72.7 0.0 3.2e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KII61856.1 - 1.7e-07 31.0 0.0 3.7e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII61856.1 - 1.9e-07 30.8 0.2 0.00053 19.6 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KII61856.1 - 1.3e-05 25.2 0.0 3.4e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 KII61856.1 - 3.8e-05 23.0 0.0 7e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.8 KII61856.1 - 0.00017 21.0 0.0 0.00033 20.1 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 KII61856.1 - 0.0051 16.2 0.0 0.51 9.7 0.0 2.4 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S28 PF05577.7 KII61856.1 - 0.0076 14.8 0.0 0.021 13.4 0.0 1.7 2 0 0 2 2 2 1 Serine carboxypeptidase S28 APC_CDC26 PF10471.4 KII61856.1 - 0.075 13.7 0.3 0.15 12.7 0.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 ArsC PF03960.10 KII61858.1 - 0.067 13.2 0.0 0.17 11.9 0.0 1.7 1 1 0 1 1 1 0 ArsC family AT_hook PF02178.14 KII61859.1 - 0.11 12.2 1.4 0.11 12.2 1.0 2.8 2 0 0 2 2 2 0 AT hook motif Nbl1_Borealin_N PF10444.4 KII61864.1 - 0.11 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Nbl1 / Borealin N terminal Peptidase_S9 PF00326.16 KII61866.1 - 1.7e-22 79.7 0.0 3.1e-14 52.7 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KII61866.1 - 9.2e-10 38.4 0.0 1.3e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KII61866.1 - 2.2e-06 27.7 0.0 0.0041 17.0 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII61866.1 - 6.5e-06 25.8 0.0 0.0026 17.3 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.13 KII61866.1 - 3.3e-05 23.2 0.0 6.6e-05 22.2 0.0 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.8 KII61866.1 - 0.00053 19.5 0.0 0.00094 18.6 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.13 KII61866.1 - 0.0031 16.9 0.0 1.7 7.9 0.0 2.2 1 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.11 KII61866.1 - 0.012 15.1 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Peptidase_S28 PF05577.7 KII61866.1 - 0.012 14.1 0.0 0.021 13.4 0.0 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Serpin PF00079.15 KII61867.1 - 6.7e-46 157.0 3.1 8.5e-46 156.7 2.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cadherin_pro PF08758.6 KII61867.1 - 0.014 15.1 0.1 0.045 13.5 0.0 1.8 2 0 0 2 2 2 0 Cadherin prodomain like RRM_1 PF00076.17 KII61869.1 - 3e-10 39.5 0.0 6.2e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII61869.1 - 1.4e-08 34.5 0.0 3.5e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII61869.1 - 0.002 17.9 0.1 0.0044 16.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 KII61869.1 - 7.4 7.0 8.3 17 5.9 4.2 2.7 1 1 1 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 DEAD PF00270.24 KII61872.1 - 9.5e-26 90.2 0.4 2.1e-25 89.1 0.3 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII61872.1 - 9.1e-22 76.7 0.1 2.3e-21 75.4 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII61872.1 - 1.5e-10 41.1 0.0 5.2e-10 39.4 0.0 1.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KII61872.1 - 0.00068 18.5 0.0 0.002 16.9 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain DUF1253 PF06862.7 KII61872.1 - 0.0011 17.5 0.2 0.018 13.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1253) AAA_22 PF13401.1 KII61872.1 - 0.0092 16.1 0.0 0.16 12.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain T4SS-DNA_transf PF02534.9 KII61872.1 - 0.021 13.4 0.0 0.035 12.7 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer T2SE PF00437.15 KII61872.1 - 0.025 13.4 0.0 0.04 12.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF87 PF01935.12 KII61872.1 - 0.054 13.2 0.2 0.25 11.1 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function DUF87 AAA_10 PF12846.2 KII61872.1 - 0.057 12.8 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Pkinase PF00069.20 KII61873.1 - 8.9e-57 192.1 0.0 1.3e-56 191.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII61873.1 - 2.5e-32 111.9 0.0 3.9e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KII61873.1 - 0.023 13.7 0.1 0.074 12.1 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KII61873.1 - 0.034 13.1 0.0 0.057 12.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Phage_Gp111 PF07410.6 KII61873.1 - 0.038 14.1 0.2 0.13 12.3 0.2 1.9 1 1 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein APH PF01636.18 KII61873.1 - 0.072 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_4 PF12799.2 KII61876.1 - 0.00084 18.8 34.5 0.13 11.9 0.1 8.0 7 2 0 8 8 8 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KII61876.1 - 0.0072 16.2 26.8 1.9 8.8 0.0 8.1 8 1 0 8 8 8 3 Leucine Rich repeat LRR_8 PF13855.1 KII61876.1 - 0.043 13.5 22.9 0.16 11.7 1.4 6.1 4 1 3 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 KII61876.1 - 0.46 10.7 0.1 0.46 10.7 0.0 7.5 6 1 1 7 7 7 0 Leucine Rich Repeat DUF1087 PF06465.8 KII61877.1 - 0.14 12.0 0.9 0.32 10.9 0.2 1.9 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1087) UBA_e1_C PF09358.5 KII61879.1 - 0.043 13.9 0.2 0.061 13.4 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin-activating enzyme e1 C-terminal domain Ldl_recept_a PF00057.13 KII61883.1 - 0.00075 19.3 18.7 0.00075 19.3 13.0 4.7 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII61883.1 - 0.0076 15.9 6.9 1.7 8.7 0.1 4.6 4 0 0 4 4 4 2 BNR/Asp-box repeat zf-CCHC PF00098.18 KII61885.1 - 5.4e-05 22.9 0.9 8.1e-05 22.3 0.6 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.1 KII61885.1 - 0.085 12.5 0.7 0.21 11.3 0.5 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII61885.1 - 0.09 12.4 0.3 0.18 11.4 0.2 1.5 1 0 0 1 1 1 0 Zinc knuckle MULE PF10551.4 KII61887.1 - 6.2e-10 39.1 0.0 1.4e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.11 KII61887.1 - 9.5e-09 35.0 0.2 1.9e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain rve PF00665.21 KII61889.1 - 2.2e-07 30.9 0.0 5.1e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain IstB_IS21 PF01695.12 KII61892.1 - 0.036 13.4 0.0 0.038 13.4 0.0 1.1 1 0 0 1 1 1 0 IstB-like ATP binding protein Ras PF00071.17 KII61893.1 - 3.8e-41 140.1 0.0 5.8e-41 139.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII61893.1 - 6.1e-15 55.7 0.0 1.2e-14 54.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 KII61893.1 - 3.4e-09 36.4 0.0 4.7e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.16 KII61893.1 - 4.2e-05 22.8 0.0 4.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KII61893.1 - 0.0046 16.1 0.2 0.011 14.9 0.1 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KII61893.1 - 0.012 15.6 0.0 0.029 14.3 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase Cas_Cas4 PF01930.12 KII61893.1 - 0.016 15.1 0.6 0.028 14.3 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function DUF83 CbiA PF01656.18 KII61893.1 - 0.019 14.3 1.5 1 8.7 0.0 2.1 1 1 1 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF89 PF01937.14 KII61893.1 - 0.027 13.2 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF89 SRP54 PF00448.17 KII61893.1 - 1.4 8.2 4.7 6.6 6.1 0.0 2.7 2 2 1 3 3 3 0 SRP54-type protein, GTPase domain DDE_3 PF13358.1 KII61896.1 - 1.1e-14 54.4 0.0 1.8e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Phage_int_SAM_1 PF02899.12 KII61896.1 - 0.056 13.5 0.0 0.095 12.8 0.0 1.3 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain HTH_23 PF13384.1 KII61897.1 - 0.0037 16.8 0.0 0.0086 15.6 0.0 1.6 1 1 0 1 1 1 1 Homeodomain-like domain DASH_Dam1 PF08653.5 KII61898.1 - 1.1 9.0 4.0 0.45 10.3 0.3 2.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 Vps39_1 PF10366.4 KII61900.1 - 0.05 13.6 1.7 0.06 13.3 1.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 MSA-2c PF12238.3 KII61900.1 - 0.092 12.4 3.1 0.11 12.1 2.1 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c FixG_C PF11614.3 KII61900.1 - 0.1 12.6 0.8 0.15 12.2 0.5 1.3 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase DX PF01666.12 KII61903.1 - 0.072 13.5 0.1 0.23 11.9 0.0 1.8 1 1 1 2 2 2 0 DX module Homeobox PF00046.24 KII61903.1 - 0.077 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Homeobox domain MULE PF10551.4 KII61904.1 - 1.4e-11 44.4 0.0 3.5e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.13 KII61904.1 - 9.7e-05 21.0 0.1 0.00014 20.5 0.1 1.2 1 0 0 1 1 1 1 Transposase, Mutator family Bromo_TP PF07524.8 KII61907.1 - 0.095 12.4 0.2 12 5.6 0.0 2.5 2 0 0 2 2 2 0 Bromodomain associated G_glu_transpept PF01019.16 KII61910.1 - 1.9e-115 386.3 0.0 2.2e-115 386.0 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Serpin PF00079.15 KII61911.1 - 2.2e-58 198.2 0.6 2.5e-58 198.0 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) ER PF01133.12 KII61911.1 - 0.021 14.4 0.7 10 5.8 0.0 3.2 2 2 1 3 3 3 0 Enhancer of rudimentary Arm PF00514.18 KII61912.1 - 2.3e-12 46.2 0.3 5.6e-06 25.9 0.0 2.6 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KII61912.1 - 8.7e-07 29.1 0.0 4.6e-05 23.6 0.0 2.1 1 1 1 2 2 2 2 HEAT repeats HEAT_EZ PF13513.1 KII61912.1 - 1.7e-05 25.1 0.1 0.00018 21.9 0.0 2.5 2 1 1 3 3 3 1 HEAT-like repeat HEAT PF02985.17 KII61912.1 - 0.00074 19.4 0.2 0.24 11.5 0.1 3.0 2 0 0 2 2 2 1 HEAT repeat TFCD_C PF12612.3 KII61912.1 - 0.0082 15.5 0.1 0.017 14.5 0.1 1.6 1 1 0 1 1 1 1 Tubulin folding cofactor D C terminal Arm PF00514.18 KII61913.1 - 6.9e-08 32.0 3.4 0.009 15.8 0.0 4.0 4 1 0 4 4 4 3 Armadillo/beta-catenin-like repeat Neurochondrin PF05536.6 KII61913.1 - 0.0021 16.4 2.1 0.021 13.1 0.3 2.0 1 1 1 2 2 2 2 Neurochondrin Arm PF00514.18 KII61914.1 - 1e-11 44.2 2.3 0.00018 21.1 0.1 5.2 5 1 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KII61914.1 - 3e-06 27.5 0.0 0.29 11.6 0.0 3.8 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.1 KII61914.1 - 0.00041 20.5 0.0 13 6.1 0.0 3.8 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.17 KII61914.1 - 0.0013 18.6 0.0 0.55 10.4 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat Proteasom_PSMB PF10508.4 KII61914.1 - 0.0027 16.0 4.5 0.17 10.0 0.3 2.5 1 1 1 2 2 2 2 Proteasome non-ATPase 26S subunit Arm_2 PF04826.8 KII61914.1 - 0.0052 15.9 8.6 0.074 12.1 0.3 3.0 1 1 2 3 3 3 2 Armadillo-like Proteasom_PSMB PF10508.4 KII61917.1 - 0.056 11.7 0.3 0.74 8.0 0.0 1.9 1 1 1 2 2 2 0 Proteasome non-ATPase 26S subunit Tenui_NCP PF04876.7 KII61918.1 - 0.084 12.4 0.7 0.091 12.3 0.5 1.1 1 0 0 1 1 1 0 Tenuivirus major non-capsid protein TrbL PF04610.9 KII61918.1 - 0.096 12.3 0.0 0.099 12.3 0.0 1.0 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein SNAP PF14938.1 KII61921.1 - 8.9e-07 28.3 0.2 1.1e-06 28.0 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII61921.1 - 0.015 15.2 0.3 0.021 14.7 0.2 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII61921.1 - 0.1 12.2 1.1 0.16 11.6 0.8 1.5 1 1 0 1 1 1 0 TPR repeat TPR_7 PF13176.1 KII61921.1 - 0.13 12.0 0.3 2.7 7.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat NSF PF02071.15 KII61921.1 - 0.68 10.7 6.0 8.9 7.3 0.2 3.3 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_1 PF00515.23 KII61921.1 - 0.81 9.3 3.7 0.59 9.8 1.1 1.9 2 1 0 2 2 2 0 Tetratricopeptide repeat IncFII_repA PF02387.10 KII61922.1 - 0.027 13.6 0.8 0.037 13.1 0.5 1.1 1 0 0 1 1 1 0 IncFII RepA protein family OGG_N PF07934.7 KII61922.1 - 0.092 12.7 0.3 0.3 11.0 0.2 2.0 1 1 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain DUF2274 PF10038.4 KII61922.1 - 0.095 12.8 0.1 0.24 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2274) Arch_ATPase PF01637.13 KII61922.1 - 0.14 11.7 1.1 0.21 11.2 0.2 1.6 2 0 0 2 2 2 0 Archaeal ATPase HTH_Tnp_4 PF13613.1 KII61923.1 - 0.033 13.7 2.3 0.042 13.3 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix of DDE superfamily endonuclease Chromosome_seg PF13889.1 KII61925.1 - 0.45 10.4 2.2 0.31 10.9 0.1 1.8 2 0 0 2 2 2 0 Chromosome segregation during meiosis rve PF00665.21 KII61927.1 - 2.2e-26 92.3 0.1 1.2e-25 89.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII61927.1 - 3e-24 85.5 0.0 5.8e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII61927.1 - 1.5e-07 31.2 0.0 3.5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII61927.1 - 0.00015 21.2 0.0 0.0004 19.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.1 KII61927.1 - 0.014 15.9 0.0 0.039 14.4 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease Mob1_phocein PF03637.12 KII61928.1 - 0.028 14.0 2.0 0.033 13.8 1.4 1.2 1 0 0 1 1 1 0 Mob1/phocein family Vg_Tdu PF07545.9 KII61928.1 - 0.081 12.3 0.1 0.51 9.8 0.0 2.2 2 0 0 2 2 2 0 Vestigial/Tondu family DDE_Tnp_IS1595 PF12762.2 KII61929.1 - 9.4e-08 32.0 0.0 1.3e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII61929.1 - 0.013 14.7 0.0 0.014 14.6 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family Haemocyan_bet_s PF14830.1 KII61931.1 - 0.085 12.5 0.3 0.21 11.3 0.2 1.6 1 0 0 1 1 1 0 Haemocyanin beta-sandwich Fork_head PF00250.13 KII61932.1 - 0.11 12.5 0.8 0.2 11.7 0.5 1.6 1 1 1 2 2 2 0 Fork head domain ComFB PF10719.4 KII61932.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Late competence development protein ComFB Tetraspannin PF00335.15 KII61935.1 - 3.2e-12 46.1 15.9 4.2e-12 45.8 11.0 1.1 1 0 0 1 1 1 1 Tetraspanin family DDE_3 PF13358.1 KII61936.1 - 0.011 15.5 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease SCP2 PF02036.12 KII61939.1 - 0.13 12.6 0.1 0.65 10.3 0.0 1.8 2 0 0 2 2 2 0 SCP-2 sterol transfer family DUF4064 PF13273.1 KII61940.1 - 0.042 13.9 4.1 0.32 11.1 2.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF2909 PF11137.3 KII61940.1 - 0.077 12.7 6.3 0.77 9.5 1.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2909) DUF4044 PF13253.1 KII61940.1 - 0.5 9.5 3.7 1.9 7.7 2.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) ABC2_membrane_5 PF13346.1 KII61941.1 - 0.099 11.9 16.7 0.1 11.9 6.7 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein SVM_signal PF12113.3 KII61941.1 - 0.12 12.1 0.7 6.4 6.7 0.1 2.9 2 0 0 2 2 2 0 SVM protein signal sequence zf-CCHC PF00098.18 KII61943.1 - 0.00012 21.8 2.4 0.00012 21.8 1.7 2.6 2 0 0 2 2 2 1 Zinc knuckle Asp_protease_2 PF13650.1 KII61943.1 - 0.0024 18.3 0.0 0.0056 17.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII61943.1 - 0.061 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII61943.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Retrotrans_gag PF03732.12 KII61943.1 - 0.17 12.0 0.0 1.8 8.6 0.0 2.5 3 0 0 3 3 3 0 Retrotransposon gag protein zf-CCHC_4 PF14392.1 KII61943.1 - 4.5 7.0 13.6 6.6 6.4 3.6 2.7 2 0 0 2 2 2 0 Zinc knuckle ABC2_membrane PF01061.19 KII61944.1 - 0.86 8.7 15.9 1.1 8.3 6.0 2.1 1 1 1 2 2 2 0 ABC-2 type transporter DUF2244 PF10003.4 KII61944.1 - 3.2 7.1 6.1 10 5.4 2.3 2.2 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) DUF4064 PF13273.1 KII61944.1 - 5.1 7.2 7.4 1.6 8.8 2.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF3687 PF12459.3 KII61945.1 - 0.023 13.9 0.5 0.064 12.5 0.4 1.8 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein Claudin_2 PF13903.1 KII61945.1 - 4.1 7.0 12.7 11 5.6 8.8 1.8 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction O-antigen_lig PF13425.1 KII61945.1 - 4.8 7.1 10.9 1 9.3 3.2 2.3 2 1 0 2 2 2 0 O-antigen ligase like membrane protein Peptidase_M56 PF05569.6 KII61946.1 - 0.36 9.7 1.5 0.37 9.7 0.2 1.5 1 1 0 1 1 1 0 BlaR1 peptidase M56 DDE_3 PF13358.1 KII61947.1 - 1.1e-12 47.9 0.0 4.1e-11 42.8 0.0 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF2718 PF10918.3 KII61947.1 - 0.063 13.3 0.1 0.092 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2718) DDE_Tnp_IS1595 PF12762.2 KII61949.1 - 4e-18 65.6 0.2 4.8e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF1975 PF09318.5 KII61949.1 - 0.025 14.1 0.2 0.033 13.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1975) ACR_tran PF00873.14 KII61949.1 - 0.054 10.9 0.1 0.071 10.5 0.1 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family PPR_1 PF12854.2 KII61950.1 - 0.29 10.6 2.2 0.47 9.9 1.5 1.3 1 0 0 1 1 1 0 PPR repeat EI24 PF07264.6 KII61951.1 - 3.7 6.9 11.0 7.1 5.9 7.6 1.5 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Claudin_2 PF13903.1 KII61952.1 - 0.95 9.1 7.8 0.63 9.7 3.9 1.8 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2254 PF10011.4 KII61953.1 - 0.086 11.2 0.7 0.12 10.8 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) YjgP_YjgQ PF03739.9 KII61953.1 - 1 8.0 5.8 1.2 7.7 4.0 1.1 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family DUF751 PF05421.6 KII61953.1 - 6.2 7.1 9.0 0.19 12.0 1.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF751) ImcF-related_N PF14331.1 KII61954.1 - 0.11 11.4 0.1 0.13 11.1 0.0 1.0 1 0 0 1 1 1 0 ImcF-related N-terminal domain Dict-STAT-coil PF09267.5 KII61957.1 - 0.015 15.5 0.0 3.1 8.0 0.0 2.2 1 1 1 2 2 2 0 Dictyostelium STAT, coiled coil TAFII55_N PF04658.8 KII61957.1 - 0.066 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 TAFII55 protein conserved region DDE_3 PF13358.1 KII61959.1 - 1.3e-06 28.2 0.3 1.7e-06 27.8 0.2 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease EMP24_GP25L PF01105.19 KII61964.1 - 4.8e-24 85.0 0.8 5.2e-24 84.9 0.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Fcf2 PF08698.6 KII61965.1 - 1.7e-18 66.4 0.4 3e-18 65.6 0.1 1.4 1 1 0 1 1 1 1 Fcf2 pre-rRNA processing S1FA PF04689.8 KII61965.1 - 4.1 7.3 9.0 1.5 8.7 1.0 2.6 2 1 1 3 3 3 0 DNA binding protein S1FA Glycos_transf_2 PF00535.21 KII61968.1 - 3.9e-38 130.7 1.2 5.4e-38 130.3 0.3 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII61968.1 - 2.8e-15 56.7 0.0 5.2e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KII61968.1 - 3.5e-13 49.2 0.4 3.5e-13 49.2 0.3 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 IncA PF04156.9 KII61968.1 - 0.002 17.7 6.3 0.0033 17.0 4.4 1.4 1 0 0 1 1 1 1 IncA protein Glyco_tranf_2_4 PF13704.1 KII61968.1 - 0.0034 17.6 0.0 0.015 15.6 0.0 2.1 1 1 1 2 2 2 1 Glycosyl transferase family 2 ERM PF00769.14 KII61968.1 - 0.0047 16.4 4.6 0.0072 15.8 3.2 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Phage_GP20 PF06810.6 KII61968.1 - 0.076 12.4 4.8 0.16 11.3 3.3 1.6 1 0 0 1 1 1 0 Phage minor structural protein GP20 DivIC PF04977.10 KII61968.1 - 0.46 9.9 6.3 3.1 7.3 0.2 2.6 2 0 0 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.3 KII61968.1 - 0.47 10.2 9.1 0.5 10.2 4.8 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF2570 PF10828.3 KII61968.1 - 0.59 9.7 6.9 0.17 11.5 2.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) CENP-F_leu_zip PF10473.4 KII61968.1 - 1.3 8.8 14.5 0.47 10.2 7.6 1.9 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Glycos_transf_1 PF00534.15 KII61969.1 - 3.7e-29 101.3 0.0 5.4e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 KII61969.1 - 8.2e-22 77.5 0.3 1.4e-21 76.8 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_4 PF13692.1 KII61969.1 - 6.4e-12 45.7 0.0 1.3e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KII61969.1 - 4e-10 39.8 0.0 9.4e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 KII61969.1 - 0.00066 19.8 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.1 KII61969.1 - 0.0064 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 NSP13 PF06460.7 KII61970.1 - 0.06 12.2 0.0 0.062 12.1 0.0 1.2 1 0 0 1 1 1 0 Coronavirus NSP13 DDE_3 PF13358.1 KII61972.1 - 1.1e-36 125.7 0.0 1.3e-36 125.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII61972.1 - 5e-08 33.0 0.0 5.5e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain DDE_1 PF03184.14 KII61972.1 - 6.8e-05 22.1 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 KII61972.1 - 0.027 13.1 0.0 0.033 12.9 0.0 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain UTRA PF07702.8 KII61976.1 - 2.6e-34 117.8 0.0 3.7e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 UTRA domain GntR PF00392.16 KII61976.1 - 1.2e-19 69.5 0.1 1.9e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family GspL_C PF12693.2 KII61976.1 - 0.016 14.9 0.1 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 GspL periplasmic domain HTH_Crp_2 PF13545.1 KII61976.1 - 0.029 14.1 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain SBP_bac_1 PF01547.20 KII61977.1 - 8.9e-05 22.3 0.0 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Homeobox PF00046.24 KII61977.1 - 0.076 12.6 0.1 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 Homeobox domain DUF1237 PF06824.6 KII61977.1 - 0.077 11.5 0.0 0.081 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1237) NYN PF01936.13 KII61978.1 - 2.3e-31 109.0 0.1 3.6e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 NYN domain OST-HTH PF12872.2 KII61978.1 - 2.2e-18 65.8 0.0 3.4e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Annexin PF00191.15 KII61980.1 - 1e-11 44.5 0.7 4.4e-05 23.3 0.0 3.7 4 0 0 4 4 4 2 Annexin Ist1 PF03398.9 KII61980.1 - 0.0027 17.1 0.1 0.0055 16.1 0.0 1.5 2 0 0 2 2 2 1 Regulator of Vps4 activity in the MVB pathway zf-UDP PF14569.1 KII61980.1 - 0.061 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger Tox-REase-3 PF15647.1 KII61980.1 - 0.13 12.1 0.1 1.6 8.5 0.1 2.1 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 3 RVP PF00077.15 KII61981.1 - 1.4e-05 24.9 0.3 5.8e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII61981.1 - 3.1e-05 23.7 0.0 6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII61981.1 - 0.00042 20.7 0.0 0.00099 19.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII61981.1 - 1.4 8.9 8.2 0.82 9.7 1.1 2.5 2 0 0 2 2 2 0 Zinc knuckle TNF PF00229.13 KII61983.1 - 0.012 15.1 1.7 0.023 14.2 0.1 2.2 2 0 0 2 2 2 0 TNF(Tumour Necrosis Factor) family Staphylcoagulse PF04022.7 KII61984.1 - 0.24 10.7 1.6 0.73 9.2 1.1 1.8 1 0 0 1 1 1 0 Staphylocoagulase repeat ARL2_Bind_BART PF11527.3 KII61986.1 - 3.2 7.5 9.5 0.24 11.1 0.7 2.2 1 1 0 2 2 2 0 The ARF-like 2 binding protein BART UPF0118 PF01594.11 KII61986.1 - 7 5.5 6.1 13 4.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF20 zf-UBR PF02207.15 KII61988.1 - 7.2e-09 35.2 18.5 1.6e-08 34.1 12.8 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-UBR PF02207.15 KII61993.1 - 2.4e-13 49.5 13.8 2.4e-13 49.5 9.6 2.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-UBR PF02207.15 KII61994.1 - 6.1e-14 51.4 13.0 1.7e-13 50.1 9.0 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) SNAP PF14938.1 KII61996.1 - 9.6e-30 103.6 4.0 1.2e-29 103.3 2.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII61996.1 - 0.0034 17.1 2.9 0.068 13.1 0.4 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 KII61996.1 - 0.011 15.8 1.2 0.064 13.4 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KII61996.1 - 0.086 13.3 1.2 1.5 9.4 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII61996.1 - 0.12 12.0 0.4 7.9 6.2 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_16 PF13432.1 KII61996.1 - 0.14 12.8 0.3 0.54 11.0 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII61996.1 - 0.16 11.9 2.1 0.43 10.4 0.7 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Kelch_6 PF13964.1 KII61997.1 - 0.09 12.9 0.8 2.9 8.2 0.1 2.3 1 1 1 2 2 2 0 Kelch motif Kelch_6 PF13964.1 KII61998.1 - 2.5e-22 78.0 6.4 2.1e-06 27.6 0.4 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII61998.1 - 4.6e-21 74.0 7.4 4e-06 26.2 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII61998.1 - 1e-17 63.6 1.3 1e-05 25.3 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII61998.1 - 1.4e-16 60.0 2.9 0.00041 20.4 0.2 4.2 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_4 PF13418.1 KII61998.1 - 1.8e-16 59.6 6.4 4.6e-05 23.0 0.6 3.3 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII61998.1 - 1.2e-08 34.4 2.0 0.006 16.3 0.0 3.4 3 0 0 3 3 3 2 Kelch motif rve PF00665.21 KII62002.1 - 0.00034 20.6 0.0 0.0004 20.4 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain DUF2772 PF10970.3 KII62005.1 - 0.018 15.1 0.1 0.023 14.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2772) Nup35_RRM_2 PF14605.1 KII62005.1 - 0.059 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF2911 PF11138.3 KII62005.1 - 0.066 12.8 0.1 0.11 12.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2911) DUF4295 PF14128.1 KII62005.1 - 0.4 10.3 3.4 4.9 6.8 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4295) rve_3 PF13683.1 KII62006.1 - 0.019 14.5 0.0 0.039 13.4 0.0 1.6 1 1 0 1 1 1 0 Integrase core domain Ssu72 PF04722.8 KII62010.1 - 0.034 13.4 0.0 0.043 13.1 0.0 1.1 1 0 0 1 1 1 0 Ssu72-like protein ATG2_CAD PF13329.1 KII62011.1 - 0.08 12.5 0.3 0.13 11.8 0.1 1.5 1 1 0 1 1 1 0 Autophagy-related protein 2 CAD motif rve PF00665.21 KII62012.1 - 2.6e-23 82.4 0.0 1.7e-22 79.7 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain rve_3 PF13683.1 KII62012.1 - 0.0057 16.1 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII62012.1 - 0.015 14.7 0.6 0.031 13.6 0.1 1.8 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger PI3_PI4_kinase PF00454.22 KII62014.1 - 9.8e-37 126.6 0.5 2.1e-36 125.5 0.3 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 KII62014.1 - 1.2e-08 34.3 0.5 2.7e-08 33.2 0.3 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.19 KII62014.1 - 0.0016 18.2 0.0 0.0039 16.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 NTP_transferase PF00483.18 KII62015.1 - 5.7e-44 150.2 0.0 7.9e-44 149.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 KII62015.1 - 7.5e-13 48.8 0.0 9.6e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 KII62015.1 - 1e-11 43.7 11.3 4.5e-07 29.0 3.5 3.6 1 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KII62015.1 - 3.1e-05 23.4 12.6 0.066 12.7 5.5 4.1 4 1 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase IspD PF01128.14 KII62015.1 - 0.028 13.9 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Peptidase_M16 PF00675.15 KII62016.1 - 3e-47 160.1 0.0 4.4e-47 159.5 0.0 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KII62016.1 - 3.1e-29 101.9 0.0 7.9e-29 100.6 0.0 1.7 2 1 0 2 2 2 1 Peptidase M16 inactive domain DDE_3 PF13358.1 KII62017.1 - 1.6e-17 63.6 0.0 2e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_M17 PF00883.16 KII62018.1 - 6.6e-96 320.8 0.0 7.5e-96 320.6 0.0 1.0 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Rpr2 PF04032.11 KII62021.1 - 0.06 13.2 0.3 0.35 10.7 0.1 2.1 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain FrhB_FdhB_C PF04432.8 KII62026.1 - 0.094 12.1 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus NifW PF03206.9 KII62029.1 - 0.0046 17.0 0.0 3.4 7.8 0.0 2.3 2 1 0 2 2 2 2 Nitrogen fixation protein NifW Consortin_C PF15281.1 KII62029.1 - 0.1 12.1 0.4 15 5.0 0.0 2.3 2 0 0 2 2 2 0 Consortin C-terminus PNPOx_C PF10590.4 KII62029.1 - 0.16 11.5 1.0 0.83 9.2 0.1 2.5 2 0 0 2 2 2 0 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Ric8 PF10165.4 KII62029.1 - 0.39 9.4 6.0 2.3 6.9 1.5 2.3 2 1 0 2 2 2 0 Guanine nucleotide exchange factor synembryn malic PF00390.14 KII62030.1 - 0.014 15.0 0.0 0.045 13.3 0.0 1.8 1 0 0 1 1 1 0 Malic enzyme, N-terminal domain PPV_E2_C PF00511.12 KII62031.1 - 0.057 13.3 0.0 0.18 11.7 0.0 1.9 1 0 0 1 1 1 0 E2 (early) protein, C terminal DDE_Tnp_IS1595 PF12762.2 KII62036.1 - 7.3e-16 58.3 0.4 1.9e-15 56.9 0.3 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII62036.1 - 0.025 14.3 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Syntaxin_2 PF14523.1 KII62037.1 - 0.4 10.7 3.9 1.8 8.6 0.8 2.2 2 0 0 2 2 2 0 Syntaxin-like protein DUF4110 PF13422.1 KII62043.1 - 0.15 11.9 0.4 0.84 9.5 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4110) MFS_1 PF07690.11 KII62044.1 - 0.0044 15.7 0.0 0.0047 15.6 0.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4040 PF13244.1 KII62044.1 - 0.019 14.9 0.4 0.034 14.1 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) DUF1469 PF07332.6 KII62044.1 - 0.032 13.9 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) DDE_1 PF03184.14 KII62050.1 - 4.8e-06 25.8 0.0 7.2e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII62050.1 - 0.0014 18.4 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_3 PF01381.17 KII62050.1 - 0.0023 17.7 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix CENP-B_N PF04218.8 KII62050.1 - 0.0065 15.8 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain LacI PF00356.16 KII62050.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_psq PF05225.11 KII62050.1 - 0.029 13.9 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_38 PF13936.1 KII62050.1 - 0.14 11.7 0.1 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.1 KII62050.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain DDE_3 PF13358.1 KII62051.1 - 1.4e-07 31.3 0.0 1.6e-07 31.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DPCD PF14913.1 KII62051.1 - 0.03 13.4 0.1 0.039 13.0 0.0 1.2 1 0 0 1 1 1 0 DPCD protein family RVT_1 PF00078.22 KII62053.1 - 2.4e-21 76.0 0.1 4.7e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII62053.1 - 5.9e-07 29.3 0.1 1.2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII62053.1 - 3.1e-05 24.4 0.0 5.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII62053.1 - 0.0004 20.1 3.3 0.0004 20.1 2.3 2.8 2 0 0 2 2 2 1 Zinc knuckle RVP_2 PF08284.6 KII62053.1 - 0.042 13.7 0.1 0.073 13.0 0.1 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII62053.1 - 0.055 13.2 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII62053.1 - 0.44 10.2 9.6 3.2 7.5 0.9 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 KII62053.1 - 0.74 9.5 10.0 0.13 12.0 1.1 2.6 1 1 1 2 2 2 0 Zinc knuckle TetR PF13972.1 KII62055.1 - 0.15 11.5 6.4 1 8.8 0.6 2.3 1 1 1 2 2 2 0 Bacterial transcriptional repressor COG2 PF06148.6 KII62055.1 - 0.56 10.0 5.4 13 5.6 3.8 2.3 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.7 KII62055.1 - 0.69 9.7 10.9 11 5.8 7.6 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sec39 PF08314.6 KII62055.1 - 3.1 5.6 15.0 5.6 4.7 5.1 2.1 1 1 1 2 2 2 0 Secretory pathway protein Sec39 Elong-fact-P_C PF09285.6 KII62056.1 - 0.0079 15.5 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 Elongation factor P, C-terminal YecM PF06185.7 KII62056.1 - 0.034 13.3 0.1 0.068 12.3 0.1 1.5 1 0 0 1 1 1 0 YecM protein DDE_3 PF13358.1 KII62056.1 - 0.036 13.8 0.0 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 DDE superfamily endonuclease DDE_3 PF13358.1 KII62059.1 - 8.8e-19 67.6 0.1 1.4e-09 37.8 0.1 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease Filament PF00038.16 KII62060.1 - 0.017 14.6 4.6 0.021 14.3 3.0 1.3 1 1 0 1 1 1 0 Intermediate filament protein DKNYY PF13644.1 KII62060.1 - 0.019 15.2 1.0 0.019 15.2 0.7 1.5 2 0 0 2 2 2 0 DKNYY family Fib_alpha PF08702.5 KII62060.1 - 0.36 10.9 3.8 0.49 10.5 0.3 2.2 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family PRKCSH-like PF12999.2 KII62061.1 - 7.5e-28 97.2 2.8 8.9e-28 97.0 1.9 1.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like Ldl_recept_a PF00057.13 KII62061.1 - 0.13 12.1 8.0 0.13 12.1 3.4 2.2 1 1 1 2 2 2 0 Low-density lipoprotein receptor domain class A Adap_comp_sub PF00928.16 KII62064.1 - 9.6e-06 24.8 0.1 2.2e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 KII62064.1 - 8.2e-05 22.3 0.2 0.00014 21.6 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain YfzA PF14118.1 KII62064.1 - 0.087 12.9 0.1 0.58 10.2 0.0 2.1 2 0 0 2 2 2 0 YfzA-like protein EF-hand_1 PF00036.27 KII62065.1 - 1.1e-36 121.3 17.5 2.6e-10 38.8 0.3 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KII62065.1 - 1.7e-32 111.3 7.4 1.8e-18 66.3 0.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KII62065.1 - 1.3e-29 99.3 5.4 5.4e-10 38.3 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KII62065.1 - 1e-28 98.6 16.4 4.7e-15 54.9 2.3 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KII62065.1 - 9.3e-24 81.6 10.2 2e-09 36.3 0.1 4.3 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.4 KII62065.1 - 6.4e-12 45.5 2.2 3.4e-05 23.8 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KII62065.1 - 5.1e-11 42.3 0.3 1.3e-05 25.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KII62065.1 - 8.2e-11 41.5 5.3 7.3e-07 28.8 0.4 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.8 KII62065.1 - 4.8e-05 22.8 1.6 0.027 14.0 0.1 2.4 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0154) TerB PF05099.8 KII62065.1 - 7.9e-05 22.4 0.2 0.0071 16.0 0.0 2.2 2 0 0 2 2 2 1 Tellurite resistance protein TerB Caleosin PF05042.8 KII62065.1 - 0.00058 19.4 0.0 0.011 15.3 0.0 2.2 1 1 0 1 1 1 1 Caleosin related protein RNA_pol_Rpb4 PF03874.11 KII62065.1 - 0.0038 17.2 3.3 0.053 13.5 0.5 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb4 RhoGEF PF00621.15 KII62065.1 - 0.027 14.3 0.1 0.1 12.4 0.0 1.9 1 1 1 2 2 2 0 RhoGEF domain Gly_acyl_tr_N PF06021.6 KII62065.1 - 0.11 11.8 0.4 0.15 11.4 0.3 1.3 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase HrpJ PF07201.6 KII62065.1 - 0.12 12.3 2.1 0.33 10.9 0.2 2.0 2 0 0 2 2 2 0 HrpJ-like domain RTX_C PF08339.5 KII62065.1 - 0.15 11.7 1.2 3 7.5 0.3 2.2 1 1 1 2 2 2 0 RTX C-terminal domain Cna_B PF05738.8 KII62065.1 - 0.17 11.6 0.5 4.6 7.0 0.0 2.6 2 1 0 2 2 2 0 Cna protein B-type domain FKBP_N PF01346.13 KII62065.1 - 0.36 10.8 3.0 0.22 11.5 0.3 2.0 2 1 1 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase MgtE_N PF03448.12 KII62065.1 - 1.3 9.3 4.9 2.9 8.2 0.3 2.2 1 1 0 2 2 2 0 MgtE intracellular N domain EF-hand_10 PF14788.1 KII62065.1 - 2 8.1 7.1 2.6 7.7 1.3 3.0 2 1 1 3 3 3 0 EF hand Helicase_C PF00271.26 KII62066.1 - 2.4e-10 40.1 0.0 8.2e-10 38.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 KII62066.1 - 6.3e-07 29.4 0.0 4.8e-06 26.6 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix domain DUF4332 PF14229.1 KII62066.1 - 0.0058 16.5 1.1 0.017 15.0 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4332) HTH_41 PF14502.1 KII62066.1 - 0.11 12.1 0.0 0.42 10.2 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain DSBA PF01323.15 KII62066.1 - 0.17 11.3 1.6 2 7.9 0.5 2.2 2 0 0 2 2 2 0 DSBA-like thioredoxin domain DEAD PF00270.24 KII62067.1 - 1.2e-12 47.7 0.0 1.4e-12 47.4 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase SecA_DEAD PF07517.9 KII62067.1 - 0.002 17.4 0.0 0.0026 17.1 0.0 1.1 1 0 0 1 1 1 1 SecA DEAD-like domain ResIII PF04851.10 KII62067.1 - 0.015 15.1 0.0 0.034 13.9 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Nup84_Nup100 PF04121.8 KII62068.1 - 1.3e-36 125.6 6.5 1.8e-36 125.1 4.5 1.2 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 RELT PF12606.3 KII62070.1 - 0.0018 17.3 0.8 0.0037 16.3 0.6 1.5 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 DUF4577 PF15145.1 KII62070.1 - 0.013 15.4 0.1 0.69 9.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) Baculo_11_kDa PF06143.6 KII62070.1 - 0.022 14.1 1.0 0.083 12.2 0.7 2.0 1 0 0 1 1 1 0 Baculovirus 11 kDa family TMEM154 PF15102.1 KII62070.1 - 0.52 10.0 11.0 7.8 6.1 7.6 2.3 1 1 0 1 1 1 0 TMEM154 protein family DUF912 PF06024.7 KII62070.1 - 1.3 9.1 5.2 1.1 9.3 2.5 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF846 PF05832.7 KII62072.1 - 2.1e-37 127.9 16.1 2.6e-37 127.6 11.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Tudor-knot PF11717.3 KII62073.1 - 1.2e-16 60.1 0.4 2.1e-16 59.3 0.3 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 KII62073.1 - 0.031 13.9 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain BLOC1_2 PF10046.4 KII62073.1 - 0.085 13.0 0.0 0.13 12.3 0.0 1.4 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MOZ_SAS PF01853.13 KII62074.1 - 3.3e-34 117.7 0.0 3.4e-34 117.7 0.0 1.0 1 0 0 1 1 1 1 MOZ/SAS family DUF1900 PF08954.6 KII62075.1 - 6.9e-22 77.4 0.0 1.1e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1900) UN_NPL4 PF11543.3 KII62075.1 - 0.14 12.4 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 DUF1900 PF08954.6 KII62076.1 - 7.3e-19 67.6 0.1 1.1e-12 47.6 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1900) WD40 PF00400.27 KII62076.1 - 2.1e-06 27.3 4.5 0.046 13.6 0.1 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat WD40 PF00400.27 KII62077.1 - 0.054 13.4 1.0 21 5.2 0.0 3.4 4 0 0 4 4 4 0 WD domain, G-beta repeat DUF1899 PF08953.6 KII62077.1 - 0.077 12.6 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1899) DUF1126 PF06565.7 KII62078.1 - 0.11 12.0 0.1 0.25 10.8 0.1 1.7 1 0 0 1 1 1 0 Repeat of unknown function (DUF1126) RPAP3_C PF13877.1 KII62078.1 - 0.49 10.4 5.4 14 5.6 0.1 3.5 3 1 0 3 3 3 0 Potential Monad-binding region of RPAP3 HSP20 PF00011.16 KII62079.1 - 5.8e-28 96.7 2.3 1.7e-15 56.6 0.1 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family DUF4097 PF13349.1 KII62079.1 - 0.0038 16.7 0.6 0.094 12.2 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4097) ATP_bind_1 PF03029.12 KII62080.1 - 1.5e-29 103.2 0.0 1.9e-29 102.9 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.18 KII62080.1 - 1.4e-05 24.5 0.0 1.5e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 KII62080.1 - 8.1e-05 23.4 0.1 9.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain DUF87 PF01935.12 KII62080.1 - 0.00036 20.4 0.1 0.00036 20.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF87 SRP54 PF00448.17 KII62080.1 - 0.00041 19.8 0.1 0.0006 19.3 0.1 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MobB PF03205.9 KII62080.1 - 0.00059 19.5 0.2 0.001 18.8 0.2 1.5 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 KII62080.1 - 0.00067 18.6 0.0 0.00078 18.4 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.7 KII62080.1 - 0.0011 18.7 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 NACHT domain 6PF2K PF01591.13 KII62080.1 - 0.0011 18.1 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.1 KII62080.1 - 0.0011 18.8 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII62080.1 - 0.0018 18.4 0.0 0.0021 18.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII62080.1 - 0.0029 17.3 0.0 0.004 16.8 0.0 1.2 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 KII62080.1 - 0.0034 17.3 0.0 0.0034 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_31 PF13614.1 KII62080.1 - 0.008 16.1 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain UPF0079 PF02367.12 KII62080.1 - 0.0091 15.6 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_14 PF13173.1 KII62080.1 - 0.0091 15.8 0.1 0.014 15.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 KII62080.1 - 0.0095 15.1 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_30 PF13604.1 KII62080.1 - 0.012 15.1 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 KII62080.1 - 0.012 15.0 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.17 KII62080.1 - 0.015 14.1 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain PduV-EutP PF10662.4 KII62080.1 - 0.018 14.5 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Trm56 PF01994.11 KII62080.1 - 0.019 14.7 0.0 0.44 10.3 0.0 2.2 2 1 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 ArgK PF03308.11 KII62080.1 - 0.022 13.5 0.0 0.029 13.1 0.0 1.1 1 0 0 1 1 1 0 ArgK protein AAA_23 PF13476.1 KII62080.1 - 0.028 14.7 0.2 0.065 13.5 0.1 1.4 1 1 0 1 1 1 0 AAA domain Miro PF08477.8 KII62080.1 - 0.031 14.7 0.0 0.042 14.3 0.0 1.3 1 0 0 1 1 1 0 Miro-like protein APS_kinase PF01583.15 KII62080.1 - 0.031 13.9 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase LpxK PF02606.9 KII62080.1 - 0.044 12.7 0.0 0.052 12.5 0.0 1.1 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase RNA_helicase PF00910.17 KII62080.1 - 0.051 13.7 0.1 0.093 12.9 0.1 1.5 1 1 0 1 1 1 0 RNA helicase AAA_18 PF13238.1 KII62080.1 - 0.057 13.7 0.0 0.061 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 KII62080.1 - 0.058 12.9 0.0 0.065 12.7 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 KII62080.1 - 0.063 12.9 0.0 0.07 12.8 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase PRK PF00485.13 KII62080.1 - 0.083 12.4 0.0 0.088 12.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.10 KII62080.1 - 0.084 12.5 0.3 0.12 12.0 0.2 1.2 1 0 0 1 1 1 0 NTPase DUF463 PF04317.7 KII62080.1 - 0.084 11.4 0.0 0.097 11.2 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 ABC_tran PF00005.22 KII62080.1 - 0.085 13.1 0.2 0.14 12.4 0.1 1.4 1 1 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.4 KII62080.1 - 0.1 11.2 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.1 KII62080.1 - 0.12 11.9 0.1 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 KII62080.1 - 0.13 11.7 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 KII62080.1 - 0.15 11.6 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.12 KII62081.1 - 1.5e-29 103.2 0.0 1.9e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.18 KII62081.1 - 1.4e-05 24.6 0.0 1.5e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 KII62081.1 - 8.4e-05 23.3 0.1 9.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 KII62081.1 - 0.00041 19.8 0.1 0.0006 19.3 0.1 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain DUF87 PF01935.12 KII62081.1 - 0.00045 20.0 0.1 0.00049 19.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF87 T2SE PF00437.15 KII62081.1 - 0.00051 19.0 0.0 0.0006 18.8 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein MobB PF03205.9 KII62081.1 - 0.00059 19.5 0.2 0.001 18.8 0.2 1.5 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 KII62081.1 - 0.0011 18.7 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 NACHT domain 6PF2K PF01591.13 KII62081.1 - 0.0011 18.1 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.1 KII62081.1 - 0.0011 18.8 0.0 0.0011 18.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII62081.1 - 0.0018 18.4 0.0 0.0021 18.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII62081.1 - 0.0029 17.3 0.0 0.004 16.8 0.0 1.2 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 KII62081.1 - 0.0035 17.3 0.0 0.0035 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_31 PF13614.1 KII62081.1 - 0.0079 16.1 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KII62081.1 - 0.009 15.9 0.1 0.014 15.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain UPF0079 PF02367.12 KII62081.1 - 0.0091 15.6 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 KTI12 PF08433.5 KII62081.1 - 0.0095 15.1 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 cobW PF02492.14 KII62081.1 - 0.012 15.0 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.1 KII62081.1 - 0.012 15.1 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 KII62081.1 - 0.014 14.2 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Trm56 PF01994.11 KII62081.1 - 0.016 14.9 0.0 0.44 10.3 0.0 2.2 2 1 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 PduV-EutP PF10662.4 KII62081.1 - 0.018 14.5 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ArgK PF03308.11 KII62081.1 - 0.021 13.6 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 ArgK protein Miro PF08477.8 KII62081.1 - 0.03 14.7 0.0 0.042 14.3 0.0 1.3 1 0 0 1 1 1 0 Miro-like protein APS_kinase PF01583.15 KII62081.1 - 0.031 13.9 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_23 PF13476.1 KII62081.1 - 0.032 14.5 0.2 0.043 14.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain LpxK PF02606.9 KII62081.1 - 0.046 12.6 0.0 0.054 12.4 0.0 1.1 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase RNA_helicase PF00910.17 KII62081.1 - 0.049 13.8 0.1 0.093 12.9 0.1 1.5 1 1 0 1 1 1 0 RNA helicase AAA_18 PF13238.1 KII62081.1 - 0.057 13.7 0.0 0.061 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 KII62081.1 - 0.058 12.9 0.0 0.065 12.7 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 KII62081.1 - 0.062 12.9 0.0 0.07 12.8 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase PRK PF00485.13 KII62081.1 - 0.083 12.4 0.0 0.088 12.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.10 KII62081.1 - 0.084 12.5 0.3 0.12 12.0 0.2 1.2 1 0 0 1 1 1 0 NTPase DUF463 PF04317.7 KII62081.1 - 0.084 11.4 0.0 0.097 11.2 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 ABC_tran PF00005.22 KII62081.1 - 0.085 13.1 0.2 0.14 12.4 0.1 1.4 1 1 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.4 KII62081.1 - 0.11 11.0 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.1 KII62081.1 - 0.12 11.9 0.1 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 KII62081.1 - 0.12 11.8 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 KII62081.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sugar_tr PF00083.19 KII62082.1 - 1.4e-35 122.7 11.9 2.5e-35 121.9 8.2 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII62082.1 - 8.8e-17 60.8 23.6 2.5e-16 59.3 16.5 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1189 PF06691.6 KII62082.1 - 0.036 13.3 3.0 0.11 11.8 2.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Pex24p PF06398.6 KII62082.1 - 0.16 10.7 1.6 0.24 10.1 0.7 1.4 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin Sugar_tr PF00083.19 KII62083.1 - 5e-15 55.0 0.8 5.8e-15 54.8 0.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter YibE_F PF07907.6 KII62083.1 - 0.028 13.6 0.8 0.034 13.3 0.6 1.1 1 0 0 1 1 1 0 YibE/F-like protein DUF912 PF06024.7 KII62083.1 - 0.15 12.1 0.7 0.22 11.5 0.5 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MscL PF01741.13 KII62083.1 - 0.24 11.5 2.3 0.26 11.4 1.6 1.3 1 1 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL YebO PF13974.1 KII62083.1 - 0.3 10.9 1.7 2.5 7.9 1.2 2.1 2 0 0 2 2 2 0 YebO-like protein DDE_Tnp_IS1595 PF12762.2 KII62084.1 - 0.0086 15.9 0.1 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain AKAP2_C PF15304.1 KII62084.1 - 0.042 13.4 0.0 0.042 13.4 0.0 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 2 C-terminus PRCC PF10253.4 KII62091.1 - 0.09 13.4 0.0 0.13 12.9 0.0 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Reg_prop PF07494.6 KII62092.1 - 0.13 12.3 0.2 58 4.2 0.0 3.3 3 0 0 3 3 3 0 Two component regulator propeller MULE PF10551.4 KII62093.1 - 0.00032 20.8 0.0 0.00059 19.9 0.0 1.6 1 1 0 1 1 1 1 MULE transposase domain RsbU_N PF08673.5 KII62095.1 - 0.1 12.6 1.0 14 5.7 0.0 2.5 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain Nbs1_C PF08599.5 KII62095.1 - 0.11 12.4 0.1 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 DNA damage repair protein Nbs1 Symplekin_C PF12295.3 KII62096.1 - 1.2e-44 152.4 3.7 1.2e-44 152.4 2.6 3.0 3 0 0 3 3 3 2 Symplekin tight junction protein C terminal TGF_beta PF00019.15 KII62097.1 - 7.5e-24 84.0 0.7 1.3e-23 83.3 0.5 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain Hormone_6 PF00236.13 KII62097.1 - 0.042 13.6 0.0 0.098 12.4 0.0 1.6 1 0 0 1 1 1 0 Glycoprotein hormone Serpin PF00079.15 KII62098.1 - 1.7e-41 142.6 0.4 1.9e-41 142.4 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Lectin_N PF03954.9 KII62099.1 - 0.089 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain RRM_1 PF00076.17 KII62100.1 - 1.8e-05 24.2 0.0 3.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII62100.1 - 0.0014 18.4 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII62100.1 - 0.0038 17.1 0.0 0.0082 16.1 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Phage_int_SAM_4 PF13495.1 KII62100.1 - 0.082 13.2 0.2 0.21 11.9 0.0 1.6 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain PAP_assoc PF03828.14 KII62101.1 - 5.1e-11 42.3 0.2 2.7e-10 40.0 0.1 2.3 2 1 0 2 2 2 1 Cid1 family poly A polymerase RRM_1 PF00076.17 KII62101.1 - 0.00016 21.2 0.0 0.00043 19.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA_NucTransf2 PF09249.6 KII62101.1 - 0.00037 20.3 0.0 0.0029 17.4 0.0 2.5 2 0 0 2 2 2 1 tRNA nucleotidyltransferase, second domain RRM_5 PF13893.1 KII62101.1 - 0.011 15.6 0.0 0.029 14.2 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII62101.1 - 0.041 13.8 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S30 PF04758.9 KII62102.1 - 2.1e-22 78.6 10.4 2.8e-22 78.2 7.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S30 ubiquitin PF00240.18 KII62102.1 - 1.2e-10 40.6 0.0 1.6e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 KII62102.1 - 0.002 17.7 0.1 0.0034 17.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PAP_assoc PF03828.14 KII62103.1 - 6.3e-13 48.4 0.3 2e-12 46.8 0.2 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase RRM_5 PF13893.1 KII62103.1 - 4.6e-06 26.3 0.6 1.3e-05 24.9 0.2 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII62103.1 - 5.9e-05 22.6 0.1 0.00014 21.4 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA_NucTransf2 PF09249.6 KII62103.1 - 0.0043 16.9 0.0 0.014 15.2 0.0 1.9 1 0 0 1 1 1 1 tRNA nucleotidyltransferase, second domain RRM_6 PF14259.1 KII62103.1 - 0.0065 16.4 0.0 0.019 14.9 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_2 PF12756.2 KII62103.1 - 0.019 15.0 0.2 0.019 15.0 0.1 3.2 4 0 0 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 KII62103.1 - 0.029 14.5 2.4 0.21 11.7 1.6 2.6 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KII62103.1 - 0.82 9.9 8.4 1.4 9.2 2.7 3.3 2 1 0 2 2 2 0 Zinc-finger of C2H2 type His_Phos_2 PF00328.17 KII62104.1 - 4.1e-78 263.1 1.2 5.1e-78 262.8 0.3 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 KII62104.1 - 1.5e-06 27.8 0.0 3.5e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain stn_TNFRSF12A PF12191.3 KII62106.1 - 0.0035 17.3 2.2 0.0078 16.2 1.5 1.6 1 1 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF2207 PF09972.4 KII62106.1 - 0.062 11.8 0.1 0.09 11.3 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3293 PF11697.3 KII62106.1 - 0.063 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3293) PSI PF01437.20 KII62106.1 - 0.21 11.8 8.1 0.37 10.9 5.6 1.4 1 0 0 1 1 1 0 Plexin repeat PRP38 PF03371.10 KII62112.1 - 5.3e-60 201.9 0.8 6.9e-60 201.5 0.5 1.1 1 0 0 1 1 1 1 PRP38 family TAF8_C PF10406.4 KII62113.1 - 0.00023 21.1 0.1 0.00048 20.1 0.0 1.5 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term GYF PF02213.11 KII62114.1 - 1.1e-07 31.2 1.7 1.1e-07 31.2 1.2 2.0 2 0 0 2 2 2 1 GYF domain Pkinase_Tyr PF07714.12 KII62115.1 - 2.7e-29 102.0 0.0 9.6e-28 96.9 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KII62115.1 - 1.5e-19 70.1 0.2 1.4e-18 66.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Kringle PF00051.13 KII62115.1 - 1.7e-15 56.8 0.7 5.4e-15 55.2 0.2 2.1 2 0 0 2 2 2 1 Kringle domain Hormone_1 PF00103.15 KII62115.1 - 0.0077 15.5 0.1 0.018 14.3 0.1 1.5 1 0 0 1 1 1 1 Somatotropin hormone family IRS PF02174.12 KII62116.1 - 0.093 12.3 0.0 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 PTB domain (IRS-1 type) rve PF00665.21 KII62117.1 - 0.003 17.6 0.0 0.0044 17.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Laminin_G_3 PF13385.1 KII62119.1 - 1.3e-08 35.2 0.0 2.1e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Hexokinase_2 PF03727.11 KII62120.1 - 5.6e-66 222.2 0.1 7.8e-66 221.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII62120.1 - 7.5e-53 178.9 0.0 1.2e-52 178.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Maelstrom PF13017.1 KII62121.1 - 0.065 12.7 0.5 0.15 11.5 0.1 1.6 2 0 0 2 2 2 0 piRNA pathway germ-plasm component Aminotran_5 PF00266.14 KII62122.1 - 2.9e-15 55.8 0.0 6e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 KII62122.1 - 8.9e-06 24.8 0.2 1.4e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Gar1 PF04410.9 KII62123.1 - 5.4e-10 38.9 0.1 9.7e-10 38.1 0.1 1.4 1 1 0 1 1 1 1 Gar1/Naf1 RNA binding region Ribosomal_L34e PF01199.13 KII62124.1 - 8.2e-41 138.1 5.5 9.5e-41 137.9 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L34e Laminin_EGF PF00053.19 KII62124.1 - 0.076 12.9 0.4 2.3 8.1 0.0 2.1 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) Fer2_BFD PF04324.10 KII62124.1 - 0.097 12.7 0.6 1.5 8.9 0.1 2.1 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain PSDC PF12588.3 KII62126.1 - 0.027 14.0 0.2 0.032 13.8 0.1 1.2 1 0 0 1 1 1 0 Phophatidylserine decarboxylase Herpes_gE PF02480.11 KII62127.1 - 0.014 13.6 0.0 0.014 13.6 0.0 2.9 1 1 3 4 4 4 0 Alphaherpesvirus glycoprotein E DUF872 PF05915.7 KII62127.1 - 0.04 13.7 0.6 0.11 12.4 0.4 2.0 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) DUF1049 PF06305.6 KII62127.1 - 0.087 12.3 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) 7tm_1 PF00001.16 KII62127.1 - 0.16 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TFIIA PF03153.8 KII62127.1 - 0.51 10.1 21.3 0.64 9.8 14.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Borrelia_rep PF03183.8 KII62127.1 - 1.3 8.9 4.8 2.9 7.8 3.3 1.6 1 0 0 1 1 1 0 Borrelia repeat protein Macoilin PF09726.4 KII62127.1 - 4 5.5 17.9 4.8 5.3 12.4 1.1 1 0 0 1 1 1 0 Transmembrane protein IER PF05760.7 KII62127.1 - 5.3 6.8 17.7 7 6.4 12.3 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) Utp14 PF04615.8 KII62127.1 - 5.6 5.0 20.4 6.8 4.7 14.1 1.0 1 0 0 1 1 1 0 Utp14 protein Mitofilin PF09731.4 KII62127.1 - 8.6 4.8 23.8 11 4.5 16.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF465 PF04325.8 KII62129.1 - 0.067 12.9 2.3 0.12 12.0 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF465) DUF883 PF05957.8 KII62129.1 - 0.13 12.6 3.3 6.5 7.2 0.2 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) MCPsignal PF00015.16 KII62129.1 - 0.32 10.4 9.9 0.044 13.3 1.1 3.0 3 1 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3053 PF11254.3 KII62129.1 - 0.36 10.0 8.0 0.026 13.7 0.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3053) Laminin_II PF06009.7 KII62129.1 - 1.1 9.0 13.4 0.34 10.6 1.8 3.0 3 0 0 3 3 3 0 Laminin Domain II ALIX_LYPXL_bnd PF13949.1 KII62129.1 - 1.3 7.9 21.9 0.47 9.3 3.3 3.6 3 1 1 4 4 4 0 ALIX V-shaped domain binding to HIV NPV_P10 PF05531.7 KII62129.1 - 1.3 9.2 6.3 1.2 9.3 0.1 3.3 4 1 0 4 4 3 0 Nucleopolyhedrovirus P10 protein V_ATPase_I PF01496.14 KII62129.1 - 3.3 5.4 18.0 0.88 7.3 1.6 2.6 1 1 2 3 3 3 0 V-type ATPase 116kDa subunit family DUF1342 PF07072.6 KII62129.1 - 3.4 7.2 11.0 0.14 11.7 1.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1342) Occludin_ELL PF07303.8 KII62129.1 - 3.5 8.4 25.2 5.3 7.8 0.2 3.9 3 1 1 4 4 4 0 Occludin homology domain Zein-binding PF04576.10 KII62129.1 - 5 7.3 10.3 0.89 9.7 1.7 2.6 2 0 0 2 2 2 0 Zein-binding TBCA PF02970.11 KII62129.1 - 8.3 6.5 15.4 0.034 14.2 2.2 3.0 4 1 0 4 4 4 0 Tubulin binding cofactor A WD40 PF00400.27 KII62130.1 - 5e-07 29.3 0.1 0.00044 20.0 0.0 3.0 2 1 0 2 2 2 2 WD domain, G-beta repeat DUF4371 PF14291.1 KII62132.1 - 0.042 13.4 0.0 0.072 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) V_ATPase_I PF01496.14 KII62134.1 - 1.3e-160 535.8 5.3 1.6e-160 535.5 3.7 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family WD40 PF00400.27 KII62135.1 - 0.00034 20.3 0.4 0.3 11.0 0.3 4.2 5 0 0 5 5 5 2 WD domain, G-beta repeat ABC_tran PF00005.22 KII62136.1 - 3.8e-22 79.0 0.0 5.4e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KII62136.1 - 2.9e-12 47.1 0.2 1.8e-07 31.3 0.0 2.1 1 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KII62136.1 - 3.5e-06 27.1 0.1 1.2e-05 25.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 KII62136.1 - 2.8e-05 23.4 0.0 0.011 14.9 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 KII62136.1 - 0.00013 21.1 1.5 0.061 12.3 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.1 KII62136.1 - 0.0002 21.4 0.0 0.00042 20.3 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.1 KII62136.1 - 0.00028 20.7 0.0 0.00082 19.2 0.0 1.8 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit DUF258 PF03193.11 KII62136.1 - 0.00044 19.4 0.0 0.00083 18.5 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 KII62136.1 - 0.00073 19.0 0.3 0.011 15.1 0.2 2.0 2 0 0 2 2 2 1 AAA-like domain cobW PF02492.14 KII62136.1 - 0.00083 18.8 0.0 0.0015 18.0 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 KII62136.1 - 0.0011 18.6 0.3 0.64 9.7 0.1 2.3 2 0 0 2 2 2 2 NTPase Septin PF00735.13 KII62136.1 - 0.0017 17.4 0.0 0.002 17.1 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 KII62136.1 - 0.0019 18.1 0.2 0.0027 17.6 0.2 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.7 KII62136.1 - 0.0021 17.7 0.2 0.0042 16.7 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_24 PF13479.1 KII62136.1 - 0.0024 17.4 0.0 0.0031 17.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 KII62136.1 - 0.0036 16.8 0.3 0.0076 15.7 0.2 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family Miro PF08477.8 KII62136.1 - 0.0071 16.8 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein AAA_29 PF13555.1 KII62136.1 - 0.0072 15.8 0.1 0.013 15.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 KII62136.1 - 0.0073 15.7 0.1 0.74 9.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KII62136.1 - 0.0086 15.9 0.0 0.24 11.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 KII62136.1 - 0.01 15.3 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.9 KII62136.1 - 0.013 15.2 0.1 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.24 KII62136.1 - 0.017 15.2 0.8 0.2 11.8 0.6 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KII62136.1 - 0.019 14.8 0.1 0.042 13.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.5 KII62136.1 - 0.026 13.7 0.1 0.081 12.1 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit T2SE PF00437.15 KII62136.1 - 0.027 13.3 0.1 0.058 12.2 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 KII62136.1 - 0.028 14.7 0.2 0.054 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain Pox_A32 PF04665.7 KII62136.1 - 0.034 13.4 0.3 0.057 12.7 0.1 1.5 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_28 PF13521.1 KII62136.1 - 0.038 13.9 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KII62136.1 - 0.048 13.8 0.0 0.092 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase MobB PF03205.9 KII62136.1 - 0.049 13.3 0.3 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 KII62136.1 - 0.068 13.9 0.1 0.079 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KII62136.1 - 0.088 13.1 0.2 0.21 11.8 0.1 1.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 KII62136.1 - 0.1 11.4 0.2 0.19 10.5 0.2 1.4 1 0 0 1 1 1 0 NB-ARC domain IstB_IS21 PF01695.12 KII62136.1 - 0.12 11.7 0.1 4 6.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein LRRNT PF01462.13 KII62137.1 - 0.031 13.7 4.0 0.12 11.9 0.7 2.4 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Mesd PF10185.4 KII62138.1 - 0.014 15.1 11.0 2 8.0 7.6 2.0 1 1 0 1 1 1 0 Chaperone for wingless signalling and trafficking of LDL receptor LAGLIDADG_1 PF00961.14 KII62138.1 - 0.24 11.9 4.3 0.11 13.0 0.4 2.0 2 0 0 2 2 2 0 LAGLIDADG endonuclease IBR PF01485.16 KII62140.1 - 0.018 14.8 2.4 0.035 13.9 1.7 1.4 1 0 0 1 1 1 0 IBR domain zf-CCHC_4 PF14392.1 KII62140.1 - 0.022 14.3 1.1 0.022 14.3 0.7 2.2 3 0 0 3 3 3 0 Zinc knuckle Zn_Tnp_IS91 PF14319.1 KII62140.1 - 0.033 13.7 2.6 0.053 13.0 1.8 1.4 1 0 0 1 1 1 0 Transposase zinc-binding domain THF_DHG_CYH PF00763.18 KII62140.1 - 0.36 10.8 1.9 1.7 8.6 0.4 2.5 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain PBP-Tp47_a PF14889.1 KII62141.1 - 0.013 14.8 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a DUF3141 PF11339.3 KII62143.1 - 0.1 10.9 0.1 0.1 10.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) HMG-CoA_red PF00368.13 KII62144.1 - 2.6e-118 394.9 0.3 3.5e-118 394.5 0.2 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase B56 PF01603.15 KII62145.1 - 2.1e-42 145.1 20.7 1.6e-18 66.5 2.4 4.2 1 1 3 4 4 4 4 Protein phosphatase 2A regulatory B subunit (B56 family) DUF3440 PF11922.3 KII62145.1 - 0.081 12.4 0.1 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3440) WD40 PF00400.27 KII62146.1 - 5.9e-55 181.3 22.7 2.4e-13 49.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KII62146.1 - 0.057 11.5 3.7 4.6 5.2 1.9 3.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 SPOC PF07744.8 KII62148.1 - 5.8e-15 55.8 0.0 1e-14 55.0 0.0 1.4 1 0 0 1 1 1 1 SPOC domain PHO4 PF01384.15 KII62149.1 - 3.2e-19 68.7 5.8 3.7e-19 68.5 4.0 1.1 1 0 0 1 1 1 1 Phosphate transporter family MtN3_slv PF03083.11 KII62149.1 - 0.029 14.2 0.3 0.029 14.2 0.2 1.9 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange DUF4239 PF14023.1 KII62149.1 - 0.063 12.6 0.6 0.1 11.9 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Cyclin_N PF00134.18 KII62151.1 - 1e-05 25.1 0.3 1.7e-05 24.3 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Tetraspannin PF00335.15 KII62153.1 - 8.6e-22 77.4 14.4 1.1e-21 77.0 10.0 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF3810 PF12725.2 KII62153.1 - 0.065 12.1 0.0 0.09 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) SieB PF14163.1 KII62153.1 - 0.16 11.5 1.5 9.8 5.7 0.1 2.3 2 0 0 2 2 2 0 Superinfection exclusion protein B Reticulon PF02453.12 KII62153.1 - 2.3 7.8 7.8 0.086 12.4 1.1 1.8 2 0 0 2 2 2 0 Reticulon PLAC8 PF04749.12 KII62154.1 - 8.6e-14 51.9 12.5 1e-13 51.7 8.7 1.1 1 0 0 1 1 1 1 PLAC8 family Vanabin-2 PF11437.3 KII62154.1 - 1.7 8.6 9.6 0.2 11.6 3.6 1.7 2 0 0 2 2 2 0 Vanadium-binding protein 2 Fibrillarin PF01269.12 KII62155.1 - 1.1e-108 361.4 0.0 1.4e-108 361.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 KII62155.1 - 1.1e-05 25.1 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 KII62155.1 - 0.016 14.7 0.1 0.028 13.9 0.0 1.3 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KII62155.1 - 0.032 13.8 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Shadoo PF14999.1 KII62155.1 - 4.7 7.0 14.5 0.042 13.7 3.1 2.1 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective RRM_1 PF00076.17 KII62157.1 - 1.5e-12 46.9 0.0 3.1e-12 45.9 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII62157.1 - 1.5e-06 28.0 0.0 3.1e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII62157.1 - 0.0035 17.1 0.0 0.0072 16.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII62157.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif GA PF01468.12 KII62157.1 - 0.12 12.5 0.6 0.32 11.1 0.3 1.7 1 1 0 1 1 1 0 GA module Actin PF00022.14 KII62158.1 - 3.1e-65 220.1 0.0 3.5e-65 219.9 0.0 1.0 1 0 0 1 1 1 1 Actin Cyt-b5 PF00173.23 KII62158.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain MOZ_SAS PF01853.13 KII62159.1 - 2e-81 271.7 0.8 2.9e-81 271.2 0.6 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 KII62159.1 - 4.7e-17 61.4 0.4 1e-16 60.3 0.3 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-C2H2_4 PF13894.1 KII62159.1 - 0.069 13.5 3.0 0.22 11.9 2.1 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 KII62159.1 - 0.078 13.3 3.5 0.28 11.5 2.4 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type FR47 PF08445.5 KII62159.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_7 PF13508.1 KII62159.1 - 0.11 12.6 0.0 0.38 10.9 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KII62159.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Tetraspannin PF00335.15 KII62162.1 - 1.7e-10 40.5 16.5 2.6e-10 39.9 11.5 1.3 1 1 0 1 1 1 1 Tetraspanin family DUF2254 PF10011.4 KII62162.1 - 1.7 6.9 4.6 2.2 6.6 3.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Tetraspannin PF00335.15 KII62163.1 - 4.7e-17 62.0 15.8 6.1e-17 61.6 10.9 1.1 1 0 0 1 1 1 1 Tetraspanin family Tetraspannin PF00335.15 KII62164.1 - 4.5e-11 42.4 8.7 5.3e-11 42.2 6.0 1.0 1 0 0 1 1 1 1 Tetraspanin family RVT_1 PF00078.22 KII62166.1 - 2e-10 40.4 1.0 3.4e-10 39.6 0.7 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PurA PF04845.8 KII62168.1 - 3.6e-08 32.7 0.3 4.5e-06 25.9 0.4 2.5 2 1 0 2 2 2 2 PurA ssDNA and RNA-binding protein V-set PF07686.12 KII62171.1 - 0.00024 20.9 0.2 0.00031 20.5 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain COX_ARM PF06481.9 KII62171.1 - 0.11 12.1 1.7 6.2 6.5 0.1 2.2 2 0 0 2 2 2 0 COX Aromatic Rich Motif DUF809 PF05663.6 KII62173.1 - 0.021 14.7 2.6 0.024 14.5 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF809) CDC45 PF02724.9 KII62173.1 - 0.059 11.4 2.7 0.054 11.5 1.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Myc_N PF01056.13 KII62173.1 - 0.087 11.9 8.7 0.12 11.5 6.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region CobT PF06213.7 KII62173.1 - 0.14 11.2 9.8 0.14 11.2 6.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.7 KII62173.1 - 7.3 4.3 17.0 8.6 4.1 11.8 1.1 1 0 0 1 1 1 0 Nop14-like family Prefoldin PF02996.12 KII62174.1 - 6.1e-22 77.5 0.5 8.4e-22 77.0 0.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.15 KII62174.1 - 0.0003 20.5 0.4 0.0023 17.6 0.0 2.2 2 0 0 2 2 2 1 Prefoldin subunit PAP_central PF04928.12 KII62174.1 - 0.043 12.6 0.2 0.045 12.5 0.1 1.1 1 0 0 1 1 1 0 Poly(A) polymerase central domain Stn1_C PF12659.2 KII62174.1 - 0.085 12.6 0.4 11 5.9 0.0 2.3 2 0 0 2 2 2 0 Telomere capping C-terminal wHTH Paramyx_P_V_C PF03210.8 KII62174.1 - 0.1 12.4 2.4 0.55 10.0 0.6 2.0 2 0 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal XPG_I PF00867.13 KII62175.1 - 0.14 12.2 0.1 0.23 11.5 0.1 1.5 1 1 0 1 1 1 0 XPG I-region Serpin PF00079.15 KII62176.1 - 2.3e-16 59.8 0.5 2e-15 56.8 0.4 1.9 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Kelch_6 PF13964.1 KII62177.1 - 6.3e-27 92.5 16.4 3e-06 27.1 0.1 5.1 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 KII62177.1 - 4.4e-24 83.9 15.3 7.8e-06 25.5 0.4 5.1 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII62177.1 - 7.8e-23 79.7 14.0 3.9e-06 26.2 0.1 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 KII62177.1 - 1.2e-16 60.3 13.7 0.0012 18.9 0.2 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.10 KII62177.1 - 6.5e-15 54.2 10.4 0.0058 16.3 0.0 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.1 KII62177.1 - 2.6e-12 46.4 8.1 0.0011 18.8 0.0 5.2 5 0 0 5 5 5 4 Kelch motif Glyco_transf_7N PF13733.1 KII62179.1 - 2e-23 82.2 0.4 3.7e-23 81.4 0.3 1.4 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.9 KII62179.1 - 3.9e-16 58.2 0.0 1e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase HTH_Tnp_ISL3 PF13542.1 KII62182.1 - 0.00032 19.8 0.0 0.00061 18.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_32 PF13565.1 KII62182.1 - 0.083 13.7 0.0 0.19 12.5 0.0 1.6 1 1 0 1 1 1 0 Homeodomain-like domain HTH_23 PF13384.1 KII62182.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Fimbrial PF00419.15 KII62184.1 - 1.2e-18 67.7 0.0 1.4e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Fimbrial protein PapC_N PF13954.1 KII62185.1 - 1.2e-39 135.2 0.0 1.4e-39 134.9 0.0 1.0 1 0 0 1 1 1 1 PapC N-terminal domain Fimbrial PF00419.15 KII62186.1 - 2.9e-21 76.2 6.5 4.6e-21 75.5 4.5 1.3 1 0 0 1 1 1 1 Fimbrial protein Fimbrial PF00419.15 KII62187.1 - 3.2e-17 63.1 6.4 3.6e-17 62.9 4.4 1.0 1 0 0 1 1 1 1 Fimbrial protein GerE PF00196.14 KII62188.1 - 7.7e-05 21.9 0.1 0.00012 21.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family FTCD PF02971.9 KII62188.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Formiminotransferase domain DSBA PF01323.15 KII62189.1 - 7.3e-10 38.7 0.8 1.2e-08 34.7 0.1 2.1 1 1 1 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.1 KII62189.1 - 9.7e-06 25.6 0.6 2.3e-05 24.4 0.4 1.6 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_5 PF13743.1 KII62189.1 - 0.0013 18.2 0.3 0.0043 16.6 0.1 1.8 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_3 PF13192.1 KII62189.1 - 0.0082 15.9 0.4 5.2 6.9 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin domain Thioredoxin_8 PF13905.1 KII62189.1 - 0.019 15.0 0.1 0.62 10.2 0.1 2.5 1 1 0 1 1 1 0 Thioredoxin-like ACT_3 PF10000.4 KII62189.1 - 0.089 12.5 0.0 0.27 10.9 0.0 1.8 2 0 0 2 2 2 0 ACT domain NAD_binding_9 PF13454.1 KII62190.1 - 1.4e-35 122.3 0.0 5.1e-35 120.5 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding GFO_IDH_MocA PF01408.17 KII62190.1 - 0.0019 18.6 0.3 0.04 14.4 0.0 2.8 3 0 0 3 3 3 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.12 KII62190.1 - 0.0085 16.5 1.4 0.031 14.6 0.1 2.5 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.13 KII62190.1 - 0.06 13.0 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K_oxygenase PF13434.1 KII62190.1 - 0.15 10.9 0.0 3 6.6 0.0 2.5 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) PALP PF00291.20 KII62191.1 - 3.1e-10 39.7 0.0 3.9e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DAO PF01266.19 KII62192.1 - 3.7e-15 55.7 1.5 1.1e-14 54.1 1.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 KII62192.1 - 6.1e-11 41.8 0.5 1.3e-07 30.9 0.2 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_2 PF00890.19 KII62192.1 - 4.3e-06 25.8 0.6 8.9e-06 24.7 0.3 1.6 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 KII62192.1 - 7.1e-05 21.8 0.9 0.0032 16.4 0.1 2.7 1 1 0 2 2 2 1 Lycopene cyclase protein 3HCDH_N PF02737.13 KII62192.1 - 0.00021 20.9 0.3 0.00042 20.0 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.1 KII62192.1 - 0.00024 21.2 0.0 0.00083 19.4 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KII62192.1 - 0.0018 17.4 0.8 0.0031 16.6 0.2 1.7 2 0 0 2 2 2 1 FAD binding domain UDPG_MGDP_dh_N PF03721.9 KII62192.1 - 0.0018 17.7 0.0 0.0026 17.1 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.18 KII62192.1 - 0.0026 17.4 0.2 0.0045 16.7 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_8 PF13450.1 KII62192.1 - 0.0031 17.4 0.4 0.011 15.7 0.3 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 KII62192.1 - 0.005 15.3 0.4 0.0091 14.4 0.3 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 KII62192.1 - 0.0053 16.6 0.0 0.0086 15.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 KII62192.1 - 0.0068 15.8 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 KII62192.1 - 0.054 13.5 0.1 0.14 12.2 0.0 1.7 2 0 0 2 2 1 0 TrkA-N domain GIDA PF01134.17 KII62192.1 - 0.054 12.3 0.8 0.082 11.7 0.5 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_10 PF13460.1 KII62192.1 - 0.077 12.9 0.2 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 NADH(P)-binding Shikimate_DH PF01488.15 KII62192.1 - 0.08 13.0 0.3 0.19 11.8 0.2 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.1 KII62192.1 - 0.082 12.6 0.9 0.39 10.4 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 KII62192.1 - 0.1 13.0 0.4 0.34 11.3 0.3 1.9 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KII62192.1 - 0.4 9.6 2.7 0.94 8.4 1.9 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase tRNA-synt_1g PF09334.6 KII62193.1 - 3.7e-47 160.8 0.0 4.9e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) PHF5 PF03660.9 KII62193.1 - 0.067 13.2 3.6 0.13 12.3 2.5 1.4 1 0 0 1 1 1 0 PHF5-like protein zf-C2H2_jaz PF12171.3 KII62193.1 - 1.4 9.1 5.1 7.7 6.7 0.3 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Cupin_2 PF07883.6 KII62194.1 - 7.2e-13 47.8 0.1 9.9e-13 47.3 0.1 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 KII62194.1 - 0.00046 19.8 0.1 0.0006 19.5 0.1 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain CENP-C_C PF11699.3 KII62194.1 - 0.0016 18.4 0.0 0.0019 18.1 0.0 1.1 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_3 PF05899.7 KII62194.1 - 0.031 13.6 0.0 0.048 13.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF861) Glyco_hydro_16 PF00722.16 KII62194.1 - 0.035 13.3 0.7 0.042 13.1 0.5 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 16 Cupin_6 PF12852.2 KII62194.1 - 0.043 13.4 0.0 0.05 13.2 0.0 1.1 1 0 0 1 1 1 0 Cupin Cupin_1 PF00190.17 KII62194.1 - 0.09 12.2 0.1 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Cupin LysR_substrate PF03466.15 KII62195.1 - 9.2e-31 106.5 0.0 1.1e-30 106.3 0.0 1.0 1 0 0 1 1 1 1 LysR substrate binding domain EamA PF00892.15 KII62196.1 - 1.2e-29 102.9 37.2 1.1e-16 61.0 11.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 KII62196.1 - 7.1e-08 32.6 35.1 3.6e-07 30.3 8.1 3.1 2 1 1 3 3 3 2 Multidrug resistance efflux transporter Multi_Drug_Res PF00893.14 KII62196.1 - 0.053 13.9 1.2 0.053 13.9 0.8 2.7 2 2 0 2 2 2 0 Small Multidrug Resistance protein DUF3961 PF13106.1 KII62196.1 - 0.12 11.9 2.7 0.63 9.6 1.8 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) UPF0546 PF10639.4 KII62196.1 - 0.76 9.6 7.8 0.45 10.3 1.7 2.8 2 1 0 2 2 2 0 Uncharacterised protein family UPF0546 DUF3754 PF12576.3 KII62196.1 - 8.1 6.0 10.2 8.6 5.9 4.3 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3754) LysR_substrate PF03466.15 KII62197.1 - 1.9e-27 95.7 0.1 2.5e-27 95.3 0.1 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.22 KII62197.1 - 5.2e-16 58.1 0.1 8.4e-16 57.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.1 KII62197.1 - 0.017 14.6 0.0 0.044 13.3 0.0 1.7 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DNA_binding_1 PF01035.15 KII62198.1 - 5.3e-25 86.9 0.0 7.9e-25 86.4 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.10 KII62198.1 - 0.0065 17.0 0.0 0.0096 16.4 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain DUF572 PF04502.8 KII62199.1 - 5.3e-83 278.9 12.6 6.6e-83 278.6 8.8 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) zf-FCS PF06467.9 KII62199.1 - 0.0051 16.4 0.5 0.16 11.6 0.1 2.3 2 0 0 2 2 2 1 MYM-type Zinc finger with FCS sequence motif DUF262 PF03235.9 KII62199.1 - 0.11 12.3 3.2 0.16 11.8 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 Lar_restr_allev PF14354.1 KII62199.1 - 0.14 12.5 0.5 1.8 8.9 0.6 2.3 1 1 1 2 2 2 0 Restriction alleviation protein Lar TF_Zn_Ribbon PF08271.7 KII62199.1 - 0.49 9.7 4.1 0.32 10.3 0.3 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding zf-ribbon_3 PF13248.1 KII62199.1 - 6.2 6.1 6.2 93 2.4 4.3 2.3 1 1 0 1 1 1 0 zinc-ribbon domain KTI12 PF08433.5 KII62203.1 - 1e-18 67.5 0.2 1.3e-18 67.1 0.1 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Arch_ATPase PF01637.13 KII62203.1 - 4.4e-05 23.2 3.4 0.00076 19.2 0.1 3.0 2 1 0 2 2 2 1 Archaeal ATPase AAA PF00004.24 KII62203.1 - 6e-05 23.2 0.0 0.00011 22.3 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 KII62203.1 - 0.00011 22.0 0.4 0.00044 20.1 0.0 2.2 2 2 1 3 3 3 1 AAA domain AAA_33 PF13671.1 KII62203.1 - 0.00015 21.6 0.0 0.0013 18.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KII62203.1 - 0.00016 21.9 0.1 0.00084 19.6 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 KII62203.1 - 0.0002 22.1 0.0 0.00044 21.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII62203.1 - 0.00034 20.7 0.1 0.0046 17.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 KII62203.1 - 0.00043 19.7 0.0 0.0026 17.2 0.0 2.3 2 1 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.1 KII62203.1 - 0.0029 17.6 0.0 0.029 14.3 0.1 2.2 1 1 1 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.17 KII62203.1 - 0.072 13.2 0.0 0.27 11.4 0.0 2.1 2 0 0 2 2 2 0 RNA helicase MobB PF03205.9 KII62203.1 - 0.077 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RVT_1 PF00078.22 KII62204.1 - 2.9e-25 88.8 0.1 7.3e-25 87.5 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII62204.1 - 5.8e-07 29.3 0.0 1.3e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII62204.1 - 1.1e-06 28.2 13.4 1.6e-05 24.6 2.3 2.9 2 0 0 2 2 2 2 Zinc knuckle rve PF00665.21 KII62204.1 - 1.7e-06 28.1 0.0 3.3e-05 23.9 0.0 2.7 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62204.1 - 0.00042 19.7 0.0 0.003 17.0 0.0 2.5 3 0 0 3 3 3 1 Integrase core domain Asp_protease_2 PF13650.1 KII62204.1 - 0.001 19.5 0.1 0.0021 18.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 KII62204.1 - 0.0016 18.3 0.2 0.0033 17.3 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII62204.1 - 0.011 15.5 0.1 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_3 PF13917.1 KII62204.1 - 0.022 14.4 11.1 1 9.1 7.7 2.5 1 1 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII62204.1 - 0.052 13.2 7.5 0.43 10.2 0.3 2.9 2 0 0 2 2 2 0 Zinc knuckle Peptidase_A2E PF12382.3 KII62204.1 - 0.055 13.2 0.1 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 Retrotransposon peptidase rve PF00665.21 KII62205.1 - 2.2e-22 79.4 0.0 3.3e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62205.1 - 1.3e-05 24.6 0.1 3.6e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain BNR PF02012.15 KII62208.1 - 0.00091 18.6 2.4 0.64 10.0 0.1 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF3786 PF12654.2 KII62210.1 - 0.019 14.2 0.1 0.022 14.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3786) Ste5_C PF12194.3 KII62210.1 - 0.19 11.3 3.3 0.23 11.0 2.3 1.1 1 0 0 1 1 1 0 Protein kinase Fus3-binding Kelch_6 PF13964.1 KII62214.1 - 1.3e-09 37.8 6.7 0.0039 17.3 0.2 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII62214.1 - 9.9e-05 22.0 0.2 0.33 10.7 0.0 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII62214.1 - 0.0012 18.9 1.4 7.4 6.8 0.0 3.6 3 1 0 3 3 3 2 Galactose oxidase, central domain Thymidylate_kin PF02223.12 KII62214.1 - 0.095 12.0 0.1 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase Kelch_1 PF01344.20 KII62214.1 - 2.2 7.8 14.5 8.2 6.0 0.0 4.2 4 1 0 4 4 4 0 Kelch motif Kelch_1 PF01344.20 KII62215.1 - 4.3e-08 32.5 0.3 4.8e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII62215.1 - 1.6e-07 31.0 0.2 0.02 14.6 0.0 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.1 KII62215.1 - 2.3e-06 27.5 0.2 0.028 14.6 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII62215.1 - 0.00072 19.2 0.2 0.073 12.8 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.1 KII62215.1 - 0.0043 17.1 0.8 1 9.5 0.0 2.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KII62215.1 - 0.013 15.4 0.6 0.3 11.0 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 KII62216.1 - 2.6e-18 65.3 5.8 3.9e-06 26.7 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII62216.1 - 7.1e-15 54.2 8.9 2.9e-06 26.6 0.4 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII62216.1 - 9.1e-15 54.1 4.6 3.4e-06 26.7 0.0 3.4 2 2 1 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII62216.1 - 2.5e-13 49.7 5.1 0.00039 20.5 0.0 3.2 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII62216.1 - 2.3e-09 36.6 8.2 6.8e-05 22.4 0.1 3.6 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 KII62216.1 - 4.9e-06 26.3 3.3 0.039 13.9 0.2 3.3 3 0 0 3 3 3 3 Kelch motif Med26 PF08711.6 KII62217.1 - 6.7e-09 35.1 0.5 1.1e-08 34.4 0.4 1.3 1 0 0 1 1 1 1 TFIIS helical bundle-like domain LEDGF PF11467.3 KII62217.1 - 0.036 13.7 0.1 0.056 13.1 0.1 1.3 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) Pkinase PF00069.20 KII62218.1 - 2.3e-17 63.0 0.2 4.3e-17 62.1 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.17 KII62218.1 - 1.9e-10 39.9 0.3 0.0096 15.9 0.0 4.7 4 0 0 4 4 4 3 HEAT repeat WD40 PF00400.27 KII62218.1 - 2e-08 33.7 0.6 0.0012 18.6 0.0 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat CLASP_N PF12348.3 KII62218.1 - 0.0015 17.9 4.1 0.019 14.3 0.0 3.5 4 0 0 4 4 4 1 CLASP N terminal Pkinase_Tyr PF07714.12 KII62218.1 - 0.0074 15.3 0.0 0.031 13.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KII62218.1 - 0.41 10.3 0.0 0.67 9.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-UBR PF02207.15 KII62220.1 - 0.012 15.3 1.7 0.52 10.0 0.7 2.1 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) rve PF00665.21 KII62223.1 - 3.1e-12 46.6 0.0 3.5e-12 46.5 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain Lipoprotein_17 PF04200.7 KII62227.1 - 0.15 12.2 2.1 0.23 11.6 1.4 1.5 1 1 0 1 1 1 0 Lipoprotein associated domain Transcrip_reg PF01709.15 KII62232.1 - 5.3e-29 101.0 1.6 6.3e-29 100.7 1.1 1.1 1 0 0 1 1 1 1 Transcriptional regulator Complex1_LYR PF05347.10 KII62232.1 - 0.14 11.9 0.4 0.93 9.3 0.0 2.4 3 0 0 3 3 3 0 Complex 1 protein (LYR family) DUF4537 PF15057.1 KII62233.1 - 4.8e-08 32.8 1.3 0.0022 17.7 0.1 2.7 3 0 0 3 3 3 2 Domain of unknown function (DUF4537) STIL_N PF15253.1 KII62234.1 - 0.006 15.3 0.4 0.007 15.1 0.3 1.0 1 0 0 1 1 1 1 SCL-interrupting locus protein N-terminus Glyco_hydro_42 PF02449.10 KII62234.1 - 0.098 11.7 0.2 0.12 11.5 0.2 1.0 1 0 0 1 1 1 0 Beta-galactosidase DUF2790 PF10976.3 KII62235.1 - 0.0096 15.6 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2790) DUF3794 PF12673.2 KII62235.1 - 0.057 13.5 0.2 0.079 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3794) E1_DerP2_DerF2 PF02221.10 KII62237.1 - 1.3e-10 41.6 0.9 1.5e-10 41.4 0.6 1.1 1 0 0 1 1 1 1 ML domain Sulfolobus_pRN PF05584.6 KII62240.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein BNR PF02012.15 KII62241.1 - 7.9e-06 24.9 0.8 1.6 8.8 0.0 3.9 3 0 0 3 3 3 3 BNR/Asp-box repeat PurA PF04845.8 KII62242.1 - 0.1 11.7 0.1 0.11 11.6 0.1 1.1 1 0 0 1 1 1 0 PurA ssDNA and RNA-binding protein DUF1504 PF07399.6 KII62242.1 - 0.2 10.2 0.4 0.52 8.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1504) Serpin PF00079.15 KII62243.1 - 8.7e-43 146.8 2.9 9.3e-43 146.7 2.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) TSLP PF15216.1 KII62244.1 - 0.067 12.9 0.2 0.14 11.8 0.1 1.6 1 1 0 1 1 1 0 Thymic stromal lymphopoietin Transglut_core PF01841.14 KII62246.1 - 7.9e-10 38.9 0.1 0.0013 18.8 0.0 2.5 2 0 0 2 2 2 2 Transglutaminase-like superfamily AAA PF00004.24 KII62248.1 - 4e-13 49.7 0.0 1.3e-12 48.0 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KII62248.1 - 4.2e-07 30.7 0.1 2.7e-06 28.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KII62248.1 - 6.2e-06 26.1 2.3 3e-05 23.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain BRCT PF00533.21 KII62248.1 - 6.9e-06 26.1 0.1 3.1e-05 24.0 0.1 2.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RNA_helicase PF00910.17 KII62248.1 - 4.8e-05 23.4 1.5 0.00015 21.8 0.0 2.5 2 1 0 2 2 2 1 RNA helicase DNA_pol3_delta PF06144.8 KII62248.1 - 0.00018 21.0 0.1 0.00018 21.0 0.0 2.6 3 0 0 3 3 3 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 KII62248.1 - 0.00019 21.5 0.1 0.021 14.9 0.1 2.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KII62248.1 - 0.0026 16.8 0.1 0.014 14.4 0.0 2.3 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 KII62248.1 - 0.0085 16.3 0.0 0.0085 16.3 0.0 2.9 3 2 0 3 3 2 1 AAA domain AAA_33 PF13671.1 KII62248.1 - 0.0088 15.9 0.0 0.024 14.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII62248.1 - 0.011 15.7 0.0 0.036 14.0 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain Sigma54_activ_2 PF14532.1 KII62248.1 - 0.016 15.2 0.0 0.054 13.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain RAMP4 PF06624.7 KII62248.1 - 0.042 13.4 0.2 0.11 12.0 0.1 1.7 1 0 0 1 1 1 0 Ribosome associated membrane protein RAMP4 DDE_3 PF13358.1 KII62249.1 - 1.1e-06 28.4 0.0 1.3e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease FliS PF02561.9 KII62249.1 - 0.015 15.1 0.0 0.019 14.8 0.0 1.1 1 0 0 1 1 1 0 Flagellar protein FliS Velvet PF11754.3 KII62250.1 - 8.4e-05 22.2 0.0 0.0001 21.9 0.0 1.1 1 0 0 1 1 1 1 Velvet factor Abhydrolase_5 PF12695.2 KII62251.1 - 1.7e-22 79.7 0.0 2.2e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KII62251.1 - 4.1e-12 46.4 0.0 1.7e-09 37.8 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KII62251.1 - 7.4e-06 25.3 0.0 0.0013 18.0 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 KII62251.1 - 5.2e-05 22.9 0.0 0.021 14.3 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 KII62251.1 - 0.00038 19.9 0.1 0.0012 18.3 0.1 1.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DUF818 PF05677.7 KII62251.1 - 0.00068 18.4 0.1 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) LIP PF03583.9 KII62251.1 - 0.0049 16.1 0.0 1.9 7.6 0.0 2.1 2 0 0 2 2 2 2 Secretory lipase Peptidase_S15 PF02129.13 KII62251.1 - 0.02 14.3 0.0 0.79 9.0 0.0 2.1 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1057 PF06342.7 KII62251.1 - 0.02 13.7 0.1 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) AXE1 PF05448.7 KII62251.1 - 0.021 13.3 0.1 0.11 10.9 0.0 2.0 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) FSH1 PF03959.8 KII62251.1 - 0.034 13.6 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.8 KII62251.1 - 0.067 12.7 0.1 0.12 11.9 0.1 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold DLH PF01738.13 KII62251.1 - 0.07 12.4 0.0 0.14 11.3 0.0 1.5 1 1 0 1 1 1 0 Dienelactone hydrolase family UPF0227 PF05728.7 KII62251.1 - 0.11 12.2 0.0 14 5.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Esterase PF00756.15 KII62251.1 - 0.16 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative esterase AF2331-like PF14556.1 KII62252.1 - 0.042 14.1 0.0 0.59 10.5 0.0 2.2 2 0 0 2 2 2 0 AF2331-like PDZ PF00595.19 KII62254.1 - 1.1e-15 57.6 2.3 3.5e-15 55.9 1.6 1.7 1 1 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII62254.1 - 0.00048 19.9 0.1 0.00069 19.4 0.1 1.3 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.1 KII62254.1 - 0.011 15.5 0.1 0.016 14.9 0.1 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain PDZ PF00595.19 KII62255.1 - 1.1e-22 79.9 0.3 1.9e-11 43.9 0.0 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII62255.1 - 8.1e-15 54.4 0.0 5.3e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 PDZ domain ZU5 PF00791.15 KII62255.1 - 7.5e-10 38.4 0.0 2e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain Guanylate_kin PF00625.16 KII62255.1 - 4.1e-06 26.3 0.1 1.2e-05 24.8 0.1 1.8 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.12 KII62255.1 - 0.00074 18.9 0.0 0.0016 17.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Tricorn_PDZ PF14685.1 KII62255.1 - 0.002 17.8 0.0 0.5 10.1 0.0 2.5 2 0 0 2 2 2 1 Tricorn protease PDZ domain SH3_9 PF14604.1 KII62255.1 - 0.019 14.5 0.0 0.057 13.0 0.0 1.9 1 0 0 1 1 1 0 Variant SH3 domain RasGEF PF00617.14 KII62256.1 - 0.027 14.2 0.4 0.032 13.9 0.3 1.1 1 0 0 1 1 1 0 RasGEF domain RHH_3 PF12651.2 KII62256.1 - 0.046 13.4 0.0 0.27 10.9 0.0 2.1 1 1 0 1 1 1 0 Ribbon-helix-helix domain CM_2 PF01817.16 KII62256.1 - 0.062 13.3 0.2 3.7 7.6 0.0 2.1 2 0 0 2 2 2 0 Chorismate mutase type II DDE_1 PF03184.14 KII62259.1 - 7.3e-08 31.8 0.0 1.4e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII62259.1 - 6.1e-05 22.7 0.2 9.8e-05 22.0 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain LacI PF00356.16 KII62259.1 - 0.016 14.7 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_23 PF13384.1 KII62259.1 - 0.017 14.7 0.4 1.3 8.8 0.0 2.5 2 0 0 2 2 2 0 Homeodomain-like domain ABC_tran PF00005.22 KII62259.1 - 0.025 14.8 0.0 0.033 14.4 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Tnp_P_element PF12017.3 KII62259.1 - 0.04 13.1 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 Transposase protein DUF3852 PF12963.2 KII62266.1 - 0.11 12.5 0.6 0.14 12.1 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3852) Plasmid_Txe PF06769.8 KII62268.1 - 0.007 16.1 0.1 0.0092 15.7 0.0 1.3 1 0 0 1 1 1 1 Plasmid encoded toxin Txe Kelch_6 PF13964.1 KII62269.1 - 1.2e-15 56.8 17.2 0.00021 21.3 0.1 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 KII62269.1 - 9.4e-14 50.9 16.3 0.011 15.4 0.1 5.7 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII62269.1 - 8.7e-13 48.0 7.3 0.0099 16.0 0.0 5.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII62269.1 - 3.3e-08 32.9 25.8 0.003 17.0 0.9 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 KII62269.1 - 1.9e-07 30.8 8.6 0.017 15.0 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 KII62269.1 - 1.3e-06 27.9 14.4 0.073 12.8 0.2 5.5 5 0 0 5 5 5 3 Kelch motif Rax2 PF12768.2 KII62269.1 - 0.33 10.1 6.7 2.7 7.1 0.1 2.7 1 1 2 3 3 3 0 Cortical protein marker for cell polarity DUF1087 PF06465.8 KII62271.1 - 0.14 12.0 0.9 0.32 10.9 0.2 1.9 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1087) Peptidase_A17 PF05380.8 KII62275.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 1 0 1 1 1 0 Pao retrotransposon peptidase Actino_peptide PF14408.1 KII62275.1 - 0.12 12.3 0.1 0.35 10.8 0.0 1.7 2 0 0 2 2 2 0 Ribosomally synthesized peptide in actinomycetes RVT_1 PF00078.22 KII62276.1 - 1.8e-07 30.7 0.0 4.9e-07 29.3 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII62276.1 - 0.089 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.18 KII62276.1 - 0.46 10.5 16.2 0.12 12.3 4.6 2.6 2 0 0 2 2 2 0 Zinc knuckle PhoQ_Sensor PF08918.5 KII62278.1 - 0.032 13.7 0.9 0.062 12.8 0.6 1.5 1 0 0 1 1 1 0 PhoQ Sensor rve PF00665.21 KII62279.1 - 4.1e-20 72.0 0.0 7.8e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62279.1 - 6.5e-05 22.3 0.1 0.00014 21.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain FLYWCH PF04500.11 KII62285.1 - 6.3e-11 42.0 0.3 1.2e-10 41.1 0.2 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain AcetylCoA_hyd_C PF13336.1 KII62286.1 - 2e-61 206.1 0.1 3.5e-61 205.3 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.10 KII62286.1 - 5.9e-25 88.1 0.0 1.1e-24 87.2 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain MAD PF05557.8 KII62289.1 - 6.6e-17 60.8 48.4 9.7e-13 47.1 1.7 3.3 2 1 1 3 3 3 3 Mitotic checkpoint protein TSC22 PF01166.13 KII62289.1 - 0.083 12.8 0.2 0.083 12.8 0.1 5.1 4 1 0 4 4 4 0 TSC-22/dip/bun family Peptidase_C71 PF12386.3 KII62289.1 - 0.14 11.5 2.0 0.21 10.9 0.1 2.2 2 0 0 2 2 2 0 Pseudomurein endo-isopeptidase Pei Reo_sigmaC PF04582.7 KII62289.1 - 8.8 5.3 12.1 0.51 9.4 3.7 2.2 2 1 0 2 2 2 0 Reovirus sigma C capsid protein Bap31 PF05529.7 KII62289.1 - 9 5.7 18.2 0.69 9.3 4.0 2.8 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like RepA_N PF06970.6 KII62290.1 - 0.018 14.8 0.4 0.063 13.0 0.1 2.0 1 1 1 2 2 2 0 Replication initiator protein A (RepA) N-terminus Peptidase_M1 PF01433.15 KII62291.1 - 1.2e-65 222.0 1.4 2e-65 221.3 0.9 1.4 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 KII62291.1 - 1.1e-30 107.0 0.0 1.5e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 KII62291.1 - 1.3e-15 57.5 0.2 2.6e-15 56.5 0.1 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily IstB_IS21_ATP PF08483.6 KII62291.1 - 0.025 14.2 0.4 0.045 13.4 0.3 1.4 1 0 0 1 1 1 0 IstB-like ATP binding N-terminal Glycogen_syn PF05693.8 KII62293.1 - 2.2e-237 789.3 0.8 1.5e-236 786.6 0.2 1.8 1 1 1 2 2 2 2 Glycogen synthase Glycos_transf_1 PF00534.15 KII62293.1 - 5.2e-06 25.9 0.0 0.0029 17.0 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 DDE_3 PF13358.1 KII62294.1 - 1.4e-08 34.6 0.0 0.00019 21.1 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_3 PF13358.1 KII62296.1 - 3.2e-12 46.4 0.0 4.3e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease TMC PF07810.8 KII62296.1 - 0.098 13.0 0.3 0.14 12.5 0.2 1.3 1 1 0 1 1 1 0 TMC domain Baculo_p24 PF05073.7 KII62297.1 - 0.0098 15.4 0.8 0.057 12.9 0.1 1.9 2 0 0 2 2 2 1 Baculovirus P24 capsid protein Tox-REase-2 PF15646.1 KII62297.1 - 0.085 12.7 0.0 0.13 12.1 0.0 1.3 1 1 0 1 1 1 0 Restriction endonuclease fold toxin 2 LIM PF00412.17 KII62298.1 - 4.8e-28 97.0 58.4 1.4e-13 50.6 4.2 6.2 5 1 2 7 7 7 4 LIM domain GluR_Homer-bdg PF10606.4 KII62298.1 - 0.16 11.8 0.3 0.3 11.0 0.2 1.5 1 0 0 1 1 1 0 Homer-binding domain of metabotropic glutamate receptor FUR PF01475.14 KII62298.1 - 0.53 10.2 6.7 0.31 10.9 2.4 2.1 1 1 1 2 2 2 0 Ferric uptake regulator family zf-RING_2 PF13639.1 KII62300.1 - 3.6e-11 42.7 10.3 7.9e-11 41.6 7.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KII62300.1 - 7.8e-10 38.6 11.6 1.5e-09 37.7 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII62300.1 - 6.4e-09 35.3 9.5 1.1e-08 34.5 6.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KII62300.1 - 2.1e-08 33.6 8.1 3.6e-08 32.9 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KII62300.1 - 1.7e-07 30.8 5.9 2.9e-07 30.1 4.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 KII62300.1 - 0.00058 19.6 2.6 0.0011 18.7 1.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 KII62300.1 - 0.0008 19.4 7.3 0.0024 17.9 5.0 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_6 PF14835.1 KII62300.1 - 0.0014 18.3 4.8 0.0031 17.2 3.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 KII62300.1 - 0.0021 17.9 10.0 0.0021 17.9 6.9 2.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KII62300.1 - 0.085 12.5 6.0 0.59 9.8 4.1 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-MIZ PF02891.15 KII62300.1 - 0.17 11.4 10.7 0.31 10.6 7.4 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger FdhE PF04216.7 KII62300.1 - 0.29 10.7 1.3 0.53 9.9 0.9 1.4 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-Nse PF11789.3 KII62300.1 - 1.9 8.0 7.9 3.6 7.1 5.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 KII62300.1 - 3.1 7.4 7.4 9.2 5.9 5.3 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain ssDNA-exonuc_C PF10141.4 KII62304.1 - 0.032 13.7 0.1 1.7 8.0 0.0 2.1 1 1 1 2 2 2 0 Single-strand DNA-specific exonuclease, C terminal domain Serpin PF00079.15 KII62305.1 - 1.1e-49 169.5 1.6 1.3e-49 169.3 1.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII62306.1 - 3.1e-24 85.8 0.2 3.7e-24 85.5 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.21 KII62308.1 - 1.4e-27 96.1 0.0 2e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII62308.1 - 4.6e-05 22.7 0.2 8.3e-05 21.9 0.2 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII62308.1 - 0.0058 16.1 0.0 0.012 15.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII62308.1 - 0.02 14.8 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 DDE domain Serpin PF00079.15 KII62310.1 - 6.4e-08 32.1 0.1 7.6e-08 31.8 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) F-box PF00646.28 KII62311.1 - 0.063 12.9 0.9 0.11 12.1 0.1 1.8 2 0 0 2 2 2 0 F-box domain HeH PF12949.2 KII62317.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 HeH/LEM domain Homeobox PF00046.24 KII62318.1 - 2.2e-06 27.2 0.7 4e-06 26.3 0.1 1.8 2 0 0 2 2 2 1 Homeobox domain HTH_23 PF13384.1 KII62320.1 - 7e-08 31.8 0.0 2.8e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII62320.1 - 3e-07 30.5 0.1 3.6e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 KII62320.1 - 9.6e-07 28.5 0.1 1.1e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain MarR_2 PF12802.2 KII62320.1 - 4.7e-06 26.1 0.1 1.1e-05 25.0 0.0 1.6 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.1 KII62320.1 - 1.2e-05 24.6 0.2 0.00017 20.9 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.1 KII62320.1 - 2.9e-05 23.9 0.0 0.0022 17.9 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_38 PF13936.1 KII62320.1 - 7.4e-05 22.2 0.4 0.00039 19.8 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.8 KII62320.1 - 8.3e-05 21.9 0.0 0.00019 20.7 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Sigma70_r4 PF04545.11 KII62320.1 - 0.00015 20.9 0.1 0.00036 19.7 0.0 1.7 2 0 0 2 2 2 1 Sigma-70, region 4 LacI PF00356.16 KII62320.1 - 0.00061 19.3 0.7 0.0086 15.6 0.2 2.7 2 1 1 3 3 3 1 Bacterial regulatory proteins, lacI family TrmB PF01978.14 KII62320.1 - 0.00068 19.3 0.0 0.002 17.8 0.0 1.7 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.14 KII62320.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_IclR PF09339.5 KII62320.1 - 0.0024 17.4 0.0 0.055 13.0 0.0 2.2 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_Tnp_ISL3 PF13542.1 KII62320.1 - 0.0038 16.3 0.0 0.013 14.6 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_3 PF01381.17 KII62320.1 - 0.0055 16.5 0.1 0.038 13.8 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix HTH_32 PF13565.1 KII62320.1 - 0.006 17.3 0.1 0.016 16.0 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain Phage_CI_repr PF07022.8 KII62320.1 - 0.0073 16.3 0.0 0.0092 16.0 0.0 1.3 1 1 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain HTH_1 PF00126.22 KII62320.1 - 0.0086 15.8 0.3 0.036 13.7 0.0 2.2 3 0 0 3 3 2 1 Bacterial regulatory helix-turn-helix protein, lysR family Bot1p PF12298.3 KII62320.1 - 0.014 15.3 1.0 1.5 8.7 0.1 2.0 1 1 0 2 2 2 0 Eukaryotic mitochondrial regulator protein Sigma70_r4_2 PF08281.7 KII62320.1 - 0.014 14.8 0.0 0.086 12.3 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 ComX PF05952.7 KII62320.1 - 0.015 14.7 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 Bacillus competence pheromone ComX HTH_Tnp_Tc3_2 PF01498.13 KII62320.1 - 0.017 15.1 0.4 0.84 9.7 0.0 2.2 2 0 0 2 2 2 0 Transposase HTH_27 PF13463.1 KII62320.1 - 0.026 14.8 0.1 0.09 13.1 0.0 1.9 1 1 1 2 2 2 0 Winged helix DNA-binding domain FliG_N PF14842.1 KII62320.1 - 0.038 14.0 0.1 0.054 13.5 0.1 1.5 1 1 0 1 1 1 0 FliG N-terminal domain MarR PF01047.17 KII62320.1 - 0.05 13.3 0.0 0.21 11.3 0.0 2.0 2 0 0 2 2 2 0 MarR family HTH_30 PF13556.1 KII62320.1 - 0.073 12.6 0.1 7.4 6.2 0.0 2.7 2 1 1 3 3 3 0 PucR C-terminal helix-turn-helix domain HTH_Tnp_1 PF01527.15 KII62320.1 - 0.084 12.8 0.1 0.12 12.3 0.0 1.4 1 1 0 1 1 1 0 Transposase NUMOD1 PF07453.8 KII62320.1 - 0.085 12.7 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 NUMOD1 domain HTH_10 PF04967.7 KII62320.1 - 0.13 11.8 0.1 0.67 9.5 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain DUF2470 PF10615.4 KII62320.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) SpoIIID PF12116.3 KII62320.1 - 0.17 11.8 1.0 1.6 8.7 0.2 2.3 1 1 1 2 2 2 0 Stage III sporulation protein D PK PF00224.16 KII62321.1 - 6.5e-100 334.1 2.8 8.1e-100 333.8 1.9 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KII62321.1 - 3.9e-23 81.2 0.0 3.7e-22 78.0 0.0 2.3 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 KII62321.1 - 3.6e-05 22.7 0.6 6.7e-05 21.8 0.4 1.3 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family DUF3127 PF11325.3 KII62321.1 - 0.03 14.3 0.2 0.096 12.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3127) PSII_Pbs27 PF13326.1 KII62322.1 - 0.048 13.6 0.3 0.13 12.2 0.0 1.7 2 0 0 2 2 2 0 Photosystem II Pbs27 RVT_1 PF00078.22 KII62323.1 - 1.6e-18 66.8 0.0 6.3e-18 64.9 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII62323.1 - 3.4e-05 23.7 0.0 7.9e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII62323.1 - 5.8e-05 22.8 0.0 0.00015 21.5 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII62323.1 - 0.00018 21.9 0.0 0.00036 20.9 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease rve PF00665.21 KII62324.1 - 2.9e-24 85.4 0.2 7.8e-24 84.0 0.1 1.7 1 1 1 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII62324.1 - 3.6e-07 29.6 0.3 7.7e-07 28.5 0.2 1.5 1 0 0 1 1 1 1 Integrase core domain MCM PF00493.18 KII62325.1 - 7e-135 449.0 0.1 9.8e-135 448.6 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 KII62325.1 - 5e-18 65.7 1.8 1.2e-17 64.5 1.3 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 KII62325.1 - 9.2e-07 28.2 0.0 0.00013 21.1 0.0 2.4 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KII62325.1 - 1.2e-05 25.0 0.0 2.3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 KII62325.1 - 0.0047 16.4 0.1 0.028 13.8 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 KII62325.1 - 0.01 15.4 0.1 0.048 13.2 0.0 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DDE_1 PF03184.14 KII62327.1 - 4.4e-21 75.0 0.1 5.5e-21 74.7 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII62328.1 - 0.0011 18.7 0.0 0.0026 17.5 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII62329.1 - 8.5e-09 35.3 0.0 1.1e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease ATE_C PF04377.10 KII62331.1 - 8.8e-32 109.8 5.0 2e-31 108.6 3.5 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 KII62331.1 - 3.8e-08 33.0 3.7 1e-07 31.6 2.6 1.8 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus DUF1829 PF08862.5 KII62333.1 - 0.33 11.2 2.1 0.36 11.1 0.3 1.9 2 1 0 2 2 2 0 Domain of unknown function DUF1829 Serpin PF00079.15 KII62334.1 - 8e-34 117.3 0.2 8.9e-34 117.2 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Lip_prot_lig_C PF10437.4 KII62335.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus Maelstrom PF13017.1 KII62336.1 - 0.081 12.3 0.1 0.54 9.7 0.0 1.9 2 0 0 2 2 2 0 piRNA pathway germ-plasm component zf-ribbon_3 PF13248.1 KII62338.1 - 0.014 14.5 1.7 0.015 14.5 0.2 1.8 2 0 0 2 2 2 0 zinc-ribbon domain tRNA_synt_2f PF02092.12 KII62338.1 - 0.06 11.8 0.0 0.074 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycyl-tRNA synthetase beta subunit A2L_zn_ribbon PF08792.5 KII62338.1 - 0.061 12.8 0.5 14 5.2 0.0 2.8 2 0 0 2 2 2 0 A2L zinc ribbon domain ADK_lid PF05191.9 KII62338.1 - 0.28 10.8 4.1 0.15 11.7 1.2 1.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid DZR PF12773.2 KII62338.1 - 0.32 10.8 2.0 0.67 9.8 1.4 1.8 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.5 KII62338.1 - 1.2 9.1 4.1 1.4 8.9 1.2 2.4 2 1 0 2 2 2 0 Zinc ribbon domain HTH_Tnp_IS630 PF01710.11 KII62341.1 - 5.5e-05 22.8 1.5 0.0015 18.2 1.0 2.2 1 1 0 1 1 1 1 Transposase HTH_23 PF13384.1 KII62341.1 - 0.00012 21.6 0.7 0.0051 16.4 0.0 3.0 2 1 1 3 3 3 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII62341.1 - 0.00014 21.8 0.9 0.042 13.8 0.2 2.3 2 0 0 2 2 2 2 Transposase CENP-B_N PF04218.8 KII62341.1 - 0.00051 19.3 0.9 0.0022 17.3 0.1 2.2 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain GerE PF00196.14 KII62341.1 - 0.00065 18.9 0.6 0.0078 15.5 0.1 2.4 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family HTH_28 PF13518.1 KII62341.1 - 0.0013 18.6 0.1 0.0044 16.9 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII62341.1 - 0.0023 18.0 0.0 0.0073 16.4 0.0 1.9 1 1 1 2 2 2 1 Winged helix-turn helix HTH_11 PF08279.7 KII62341.1 - 0.01 15.4 0.5 0.21 11.2 0.0 2.6 3 0 0 3 3 3 0 HTH domain HTH_10 PF04967.7 KII62341.1 - 0.015 14.9 0.1 0.084 12.4 0.0 2.1 2 0 0 2 2 2 0 HTH DNA binding domain BrkDBD PF09607.5 KII62341.1 - 0.02 14.4 0.1 0.044 13.3 0.0 1.6 1 0 0 1 1 1 0 Brinker DNA-binding domain DUF2481 PF10654.4 KII62341.1 - 0.022 14.4 1.0 0.052 13.2 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2481) HTH_7 PF02796.10 KII62341.1 - 0.028 14.2 0.5 0.17 11.7 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase TrmB PF01978.14 KII62341.1 - 0.046 13.4 0.4 2.9 7.6 0.0 2.7 2 1 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Terminase_5 PF06056.7 KII62341.1 - 0.054 13.0 0.0 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_38 PF13936.1 KII62341.1 - 0.083 12.4 1.2 2.1 7.9 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain Arg_repressor PF01316.16 KII62341.1 - 0.09 12.3 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_36 PF13730.1 KII62341.1 - 0.16 12.0 0.7 1.3 9.2 0.1 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain SopA_C PF13979.1 KII62342.1 - 0.019 14.5 0.7 0.024 14.2 0.5 1.1 1 0 0 1 1 1 0 SopA-like catalytic domain Serpin PF00079.15 KII62345.1 - 1.8e-44 152.3 2.6 2.1e-44 152.2 1.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.1 KII62346.1 - 0.027 13.6 0.3 0.079 12.0 0.2 1.6 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP DUF3290 PF11694.3 KII62347.1 - 2.2 8.0 8.7 0.34 10.6 2.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) DDE_3 PF13358.1 KII62348.1 - 5.2e-06 26.2 0.2 0.00083 19.1 0.0 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease Ribonuclease_P PF00825.13 KII62348.1 - 0.084 12.7 0.0 0.089 12.6 0.0 1.1 1 0 0 1 1 1 0 Ribonuclease P Serpin PF00079.15 KII62349.1 - 8.4e-44 150.2 0.6 9.2e-44 150.0 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) GTA_TIM PF13547.1 KII62349.1 - 0.026 13.4 0.1 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 GTA TIM-barrel-like domain NAF PF03822.9 KII62350.1 - 0.17 11.6 1.1 0.43 10.3 0.8 1.8 1 1 0 1 1 1 0 NAF domain Hydrolase_like PF13242.1 KII62351.1 - 1.5e-12 47.0 0.0 2.8e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 KII62351.1 - 1.9e-07 31.7 0.0 2.3e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 KII62351.1 - 0.058 12.7 0.0 0.15 11.3 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase HALZ PF02183.13 KII62351.1 - 0.21 11.3 1.9 17 5.2 0.2 3.0 3 0 0 3 3 3 0 Homeobox associated leucine zipper TPR_11 PF13414.1 KII62353.1 - 4.4e-16 58.2 1.1 2.1e-12 46.5 0.0 2.1 1 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 KII62353.1 - 1.1e-14 53.3 2.1 3.9e-07 29.3 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KII62353.1 - 9.5e-12 43.8 2.2 2.9e-05 23.6 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 KII62353.1 - 8.5e-10 39.0 0.1 5.6e-07 30.0 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII62353.1 - 2.2e-06 27.5 0.2 0.00064 19.6 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII62353.1 - 4e-06 26.2 0.4 0.00014 21.4 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 KII62353.1 - 7.2e-06 26.2 0.0 0.00084 19.6 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KII62353.1 - 1.3e-05 24.9 0.1 3.1e-05 23.7 0.1 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 KII62353.1 - 0.00033 20.7 0.4 0.00053 20.0 0.3 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KII62353.1 - 0.00053 20.3 0.0 0.5 11.1 0.0 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat ChAPs PF09295.5 KII62353.1 - 0.046 12.4 0.0 0.056 12.1 0.0 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_17 PF13431.1 KII62353.1 - 0.062 13.5 0.1 7.5 7.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat 14-3-3 PF00244.15 KII62355.1 - 9.5e-84 280.1 10.5 1.1e-83 279.9 7.3 1.0 1 0 0 1 1 1 1 14-3-3 protein Pox_VLTF3 PF04947.9 KII62355.1 - 0.021 14.3 1.3 0.068 12.6 0.2 2.2 2 1 0 2 2 2 0 Poxvirus Late Transcription Factor VLTF3 like DUF1759 PF03564.10 KII62355.1 - 0.043 13.6 0.5 0.043 13.6 0.4 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1759) DUF4120 PF13496.1 KII62355.1 - 0.58 10.2 2.3 1.1 9.3 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4120) GCK PF07802.6 KII62355.1 - 3.8 7.7 7.0 0.76 9.9 0.8 2.8 3 1 0 3 3 3 0 GCK domain Annexin PF00191.15 KII62356.1 - 2.3e-20 72.2 12.5 1.1e-08 34.7 0.3 3.6 4 0 0 4 4 4 3 Annexin DUF1474 PF07342.6 KII62357.1 - 0.019 15.1 0.3 0.082 13.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) NEMO PF11577.3 KII62361.1 - 0.0078 15.9 0.6 0.012 15.2 0.4 1.3 1 0 0 1 1 1 1 NF-kappa-B essential modulator NEMO RmuC PF02646.11 KII62361.1 - 0.014 14.2 0.7 0.015 14.1 0.5 1.1 1 0 0 1 1 1 0 RmuC family DUF2681 PF10883.3 KII62361.1 - 0.024 14.8 0.2 0.051 13.7 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Cauli_AT PF03233.8 KII62361.1 - 0.034 13.8 1.7 0.046 13.4 1.2 1.2 1 0 0 1 1 1 0 Aphid transmission protein DUF972 PF06156.8 KII62361.1 - 0.044 14.1 0.5 0.045 14.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Atg14 PF10186.4 KII62361.1 - 0.046 12.6 1.0 0.049 12.5 0.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 RRF PF01765.14 KII62361.1 - 0.047 13.1 1.3 0.061 12.7 0.9 1.2 1 0 0 1 1 1 0 Ribosome recycling factor DUF507 PF04368.8 KII62361.1 - 0.065 12.8 2.5 0.1 12.2 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF507) DASH_Duo1 PF08651.5 KII62361.1 - 0.067 12.7 2.0 0.075 12.6 0.1 1.9 2 0 0 2 2 2 0 DASH complex subunit Duo1 DUF3139 PF11337.3 KII62361.1 - 0.35 11.1 2.0 0.82 9.9 0.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3139) IncA PF04156.9 KII62361.1 - 0.57 9.7 4.5 0.9 9.1 3.1 1.4 1 1 0 1 1 1 0 IncA protein DUF3450 PF11932.3 KII62362.1 - 8.7e-05 21.9 3.2 8.7e-05 21.9 2.2 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) DUF3920 PF13058.1 KII62362.1 - 0.0012 18.6 3.5 0.0017 18.1 2.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3920) IncA PF04156.9 KII62362.1 - 0.0016 18.0 12.1 0.013 15.1 8.4 1.9 1 1 0 1 1 1 1 IncA protein CENP-F_leu_zip PF10473.4 KII62362.1 - 0.0069 16.2 3.3 0.0069 16.2 2.3 2.1 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_tail_1 PF01576.14 KII62362.1 - 0.02 12.6 11.9 0.15 9.7 8.2 1.9 1 1 0 1 1 1 0 Myosin tail Sec2p PF06428.6 KII62362.1 - 0.073 12.9 7.1 0.51 10.2 0.1 2.7 1 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p TMF_TATA_bd PF12325.3 KII62362.1 - 0.11 12.2 11.7 0.11 12.2 4.2 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding FlaC_arch PF05377.6 KII62362.1 - 0.11 12.4 10.6 0.57 10.1 2.0 3.0 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Mt_ATP-synt_D PF05873.7 KII62362.1 - 0.21 11.2 6.1 3.3 7.3 4.1 2.3 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) DUF972 PF06156.8 KII62362.1 - 0.32 11.3 7.3 0.23 11.8 1.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF4515 PF14988.1 KII62362.1 - 0.43 10.2 10.8 0.062 12.9 1.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) Spc7 PF08317.6 KII62362.1 - 0.46 9.1 16.5 0.05 12.2 4.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein GvpK PF05121.7 KII62362.1 - 1.8 8.4 6.6 15 5.4 2.5 2.2 1 1 1 2 2 2 0 Gas vesicle protein K Laminin_II PF06009.7 KII62362.1 - 2.1 8.1 8.3 3.9 7.2 0.8 2.2 1 1 1 2 2 2 0 Laminin Domain II TMCO5 PF14992.1 KII62362.1 - 3.2 6.7 14.8 0.48 9.5 4.0 2.0 1 1 0 2 2 2 0 TMCO5 family Cas_Cas6 PF01881.11 KII62362.1 - 3.8 7.7 12.5 0.32 11.2 2.5 2.2 1 1 0 2 2 2 0 CRISPR associated protein Cas6 DUF4094 PF13334.1 KII62362.1 - 4 7.9 8.8 24 5.4 0.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) TMF_DNA_bd PF12329.3 KII62362.1 - 4.6 7.1 9.7 0.61 9.9 1.3 2.8 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF848 PF05852.6 KII62362.1 - 5.5 6.8 9.7 4 7.2 0.4 2.6 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Wbp11 PF09429.5 KII62362.1 - 6.2 6.8 7.7 11 6.1 0.2 3.2 2 1 2 4 4 4 0 WW domain binding protein 11 V_ATPase_I PF01496.14 KII62362.1 - 9.6 3.9 12.4 2.9 5.6 0.7 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Gemin6 PF06372.7 KII62363.1 - 0.0048 16.2 0.0 0.009 15.3 0.0 1.4 1 0 0 1 1 1 1 Gemin6 protein zf-UBR PF02207.15 KII62365.1 - 5.6e-10 38.7 10.4 7.9e-10 38.3 7.2 1.2 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-LYAR PF08790.6 KII62365.1 - 0.19 11.4 0.7 0.19 11.4 0.5 2.9 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger CAP PF00188.21 KII62366.1 - 0.0014 19.1 0.5 0.002 18.6 0.3 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF4504 PF14953.1 KII62366.1 - 0.0075 15.6 0.2 0.016 14.5 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4504) DUF2604 PF10790.4 KII62366.1 - 0.066 13.3 0.0 0.28 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein of Unknown function (DUF2604) F_actin_bind PF08919.5 KII62367.1 - 0.016 14.9 0.0 0.039 13.6 0.0 1.7 1 0 0 1 1 1 0 F-actin binding MerR_2 PF13591.1 KII62370.1 - 0.0048 16.4 0.0 0.0099 15.4 0.0 1.6 1 1 0 1 1 1 1 MerR HTH family regulatory protein ROK PF00480.15 KII62370.1 - 0.086 12.6 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 ROK family SNAP PF14938.1 KII62375.1 - 3.2e-11 42.9 6.1 4.2e-11 42.5 4.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_20 PF14561.1 KII62375.1 - 0.0061 16.6 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII62375.1 - 0.024 14.5 3.3 2.3 8.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII62375.1 - 0.077 12.6 2.6 6.1 6.5 0.1 3.2 2 1 0 2 2 2 0 TPR repeat TPR_12 PF13424.1 KII62375.1 - 0.087 12.7 5.4 0.088 12.7 0.4 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII62375.1 - 0.49 10.1 4.3 19 5.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.1 KII62376.1 - 3.7e-16 59.1 8.0 4.5e-16 58.8 5.5 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII62376.1 - 0.00036 20.3 2.2 1.6 8.6 0.3 3.7 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII62376.1 - 0.0013 18.4 1.9 0.61 10.1 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 KII62376.1 - 0.002 18.4 0.3 8.7 7.0 0.0 4.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KII62376.1 - 0.0031 17.1 1.1 4.1 7.4 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 KII62376.1 - 0.008 16.2 5.9 0.033 14.3 0.1 3.3 1 1 3 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 KII62376.1 - 0.016 14.9 1.1 0.016 14.9 0.7 5.1 6 1 1 7 7 7 0 Tetratricopeptide repeat 2-ph_phosp PF04029.9 KII62376.1 - 0.047 12.6 0.2 0.092 11.6 0.2 1.5 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase Curto_V2 PF07325.6 KII62376.1 - 0.066 12.8 0.3 0.066 12.8 0.2 2.9 3 0 0 3 3 3 0 Curtovirus V2 protein TruD PF01142.13 KII62376.1 - 0.068 11.8 0.3 0.093 11.3 0.1 1.5 1 1 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) TPR_1 PF00515.23 KII62376.1 - 0.53 9.9 11.1 0.37 10.4 0.5 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF2096 PF09869.4 KII62376.1 - 0.63 9.8 6.2 0.22 11.3 0.8 2.5 2 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) DDE_3 PF13358.1 KII62377.1 - 0.0015 18.2 0.6 0.025 14.3 0.1 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_11 PF08279.7 KII62378.1 - 0.069 12.8 0.4 0.14 11.7 0.1 1.7 2 0 0 2 2 2 0 HTH domain F-112 PF09645.5 KII62378.1 - 0.24 11.3 1.2 0.41 10.5 0.1 1.8 1 1 1 2 2 2 0 F-112 protein DDE_3 PF13358.1 KII62383.1 - 3.3e-29 101.5 0.0 3.9e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII62383.1 - 1e-05 24.7 0.0 0.00056 19.1 0.0 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease MULE PF10551.4 KII62386.1 - 0.019 15.1 0.1 0.052 13.7 0.0 1.8 2 0 0 2 2 2 0 MULE transposase domain CDC14 PF08045.6 KII62387.1 - 0.013 14.5 0.1 0.02 14.0 0.1 1.2 1 0 0 1 1 1 0 Cell division control protein 14, SIN component Homeobox PF00046.24 KII62389.1 - 1.5e-08 34.1 1.9 1.5e-08 34.1 1.3 1.8 2 0 0 2 2 2 1 Homeobox domain SopA PF13981.1 KII62389.1 - 0.031 14.3 0.3 0.087 12.8 0.1 1.8 2 0 0 2 2 2 0 SopA-like central domain BNR PF02012.15 KII62391.1 - 0.0018 17.7 0.2 0.57 10.2 0.0 3.4 3 0 0 3 3 3 1 BNR/Asp-box repeat ADK_lid PF05191.9 KII62391.1 - 0.27 10.9 2.2 0.52 10.0 0.7 2.2 2 0 0 2 2 2 0 Adenylate kinase, active site lid RNA_helicase PF00910.17 KII62392.1 - 3.6e-06 27.0 0.0 8e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 RNA helicase SulA PF03846.9 KII62394.1 - 4.1e-59 197.4 4.5 5.2e-59 197.1 3.1 1.1 1 0 0 1 1 1 1 Cell division inhibitor SulA OmpA_membrane PF01389.12 KII62395.1 - 2.9e-74 248.5 2.5 4e-74 248.0 1.8 1.2 1 0 0 1 1 1 1 OmpA-like transmembrane domain OmpA PF00691.15 KII62395.1 - 2.9e-21 75.6 0.1 8.2e-21 74.2 0.0 1.8 1 1 0 1 1 1 1 OmpA family OMP_b-brl PF13505.1 KII62395.1 - 3.2e-21 76.0 11.7 5.5e-21 75.2 8.1 1.3 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain DUF3187 PF11383.3 KII62395.1 - 0.092 11.8 0.1 0.22 10.5 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3187) Ribosomal_L22 PF00237.14 KII62395.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e MatP PF06303.7 KII62396.1 - 2.9e-74 247.9 6.5 3.2e-74 247.7 4.5 1.0 1 0 0 1 1 1 1 Organiser of macrodomain of Terminus of chromosome RHH_4 PF13467.1 KII62396.1 - 0.00046 20.0 0.1 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 Ribbon-helix-helix domain TMF_TATA_bd PF12325.3 KII62396.1 - 0.011 15.4 3.0 0.62 9.8 2.1 2.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding AAA_33 PF13671.1 KII62396.1 - 0.017 14.9 0.3 0.024 14.5 0.2 1.3 1 0 0 1 1 1 0 AAA domain TUG-UBL1 PF11470.3 KII62396.1 - 0.12 12.3 0.3 1.4 8.8 0.1 2.2 2 0 0 2 2 2 0 GLUT4 regulating protein TUG ABC_tran PF00005.22 KII62398.1 - 3e-24 85.8 0.0 2.5e-12 47.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KII62398.1 - 5.4e-09 36.4 0.0 0.00034 20.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain ABC_tran_2 PF12848.2 KII62398.1 - 2.3e-08 33.7 1.6 4.9e-08 32.6 1.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.1 KII62398.1 - 7.9e-05 22.7 1.0 0.00091 19.2 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KII62398.1 - 0.00019 21.5 0.0 0.022 14.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain T2SE PF00437.15 KII62398.1 - 0.0017 17.3 0.0 0.0028 16.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA PF00004.24 KII62398.1 - 0.0036 17.5 0.0 0.0081 16.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KII62398.1 - 0.0042 17.9 5.1 0.035 14.9 0.0 3.3 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 KII62398.1 - 0.0046 16.1 0.1 0.0077 15.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 KII62398.1 - 0.0049 16.7 0.0 0.018 14.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KII62398.1 - 0.005 16.3 0.1 0.017 14.6 0.0 1.9 2 0 0 2 2 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.7 KII62398.1 - 0.0056 15.7 0.1 0.35 9.9 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin Arch_ATPase PF01637.13 KII62398.1 - 0.01 15.5 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase DUF3288 PF11691.3 KII62398.1 - 0.011 15.4 0.2 0.031 14.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3288) AAA_28 PF13521.1 KII62398.1 - 0.012 15.5 0.4 0.035 14.0 0.0 2.0 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 KII62398.1 - 0.012 15.1 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain UPF0079 PF02367.12 KII62398.1 - 0.014 15.0 0.1 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 KII62398.1 - 0.014 15.0 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_10 PF12846.2 KII62398.1 - 0.022 14.1 0.2 0.074 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain AAA_23 PF13476.1 KII62398.1 - 0.024 14.9 0.0 0.024 14.9 0.0 2.3 2 1 0 2 2 1 0 AAA domain AAA_5 PF07728.9 KII62398.1 - 0.037 13.7 0.1 0.16 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.4 KII62398.1 - 0.043 13.3 0.1 0.074 12.5 0.1 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.17 KII62398.1 - 0.057 13.5 0.0 0.16 12.1 0.0 1.7 2 0 0 2 2 1 0 RNA helicase Lipocalin_2 PF08212.7 KII62398.1 - 0.063 13.0 0.1 0.16 11.7 0.1 1.8 1 0 0 1 1 1 0 Lipocalin-like domain AAA_33 PF13671.1 KII62398.1 - 0.065 13.1 0.3 0.15 11.9 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_15 PF13175.1 KII62398.1 - 0.088 11.8 0.0 1.2 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Miro PF08477.8 KII62398.1 - 0.1 13.1 0.0 0.29 11.6 0.0 1.8 2 0 0 2 2 1 0 Miro-like protein MobB PF03205.9 KII62398.1 - 0.13 11.9 0.1 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SMC_N PF02463.14 KII62398.1 - 0.16 11.1 0.0 0.37 9.9 0.0 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Pox_A32 PF04665.7 KII62398.1 - 0.18 11.0 0.1 0.44 9.7 0.0 1.6 1 1 1 2 2 2 0 Poxvirus A32 protein NTPase_1 PF03266.10 KII62398.1 - 0.31 10.7 3.3 0.89 9.2 0.1 2.2 2 0 0 2 2 2 0 NTPase Methyltrans_SAM PF10672.4 KII62399.1 - 2.6e-22 79.0 0.1 3.1e-22 78.7 0.1 1.1 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.10 KII62399.1 - 6.3e-10 38.7 0.0 9.4e-10 38.1 0.0 1.3 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_26 PF13659.1 KII62399.1 - 3.2e-08 33.6 0.0 3.9e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KII62399.1 - 4.5e-06 26.1 0.0 5.7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 KII62399.1 - 9.2e-06 26.2 0.0 1.4e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII62399.1 - 2.3e-05 24.0 0.0 2.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 KII62399.1 - 0.0005 19.6 0.0 0.00064 19.3 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_24 PF13578.1 KII62399.1 - 0.0019 18.9 0.0 0.0044 17.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII62399.1 - 0.0039 17.6 0.0 0.012 16.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 KII62399.1 - 0.012 15.1 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase CDC37_N PF03234.9 KII62401.1 - 1.4e-27 97.1 11.4 2.8e-27 96.1 7.9 1.4 1 1 0 1 1 1 1 Cdc37 N terminal kinase binding DUF964 PF06133.6 KII62401.1 - 0.025 14.6 7.9 0.039 13.9 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF964) MscS_porin PF12795.2 KII62401.1 - 0.032 13.5 3.7 0.044 13.1 2.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF4446 PF14584.1 KII62401.1 - 0.035 13.9 1.4 0.051 13.4 0.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) Seryl_tRNA_N PF02403.17 KII62401.1 - 0.083 12.9 5.7 0.14 12.2 4.0 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF4140 PF13600.1 KII62401.1 - 0.69 10.3 5.1 1.6 9.2 0.8 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) bZIP_1 PF00170.16 KII62401.1 - 1.5 8.8 7.4 1.2 9.1 0.3 2.3 2 0 0 2 2 2 0 bZIP transcription factor DUF972 PF06156.8 KII62401.1 - 2.1 8.7 7.6 6.7 7.1 5.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) FlaC_arch PF05377.6 KII62401.1 - 3.9 7.4 7.8 6.6 6.7 0.2 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) EMP24_GP25L PF01105.19 KII62401.1 - 7.4 6.2 8.6 2.7e+02 1.1 6.0 2.1 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD RhoGAP PF00620.22 KII62402.1 - 0.037 13.6 1.1 0.052 13.1 0.8 1.3 1 0 0 1 1 1 0 RhoGAP domain SH2 PF00017.19 KII62403.1 - 0.018 14.8 0.2 0.07 12.9 0.0 2.2 2 0 0 2 2 2 0 SH2 domain VPS9 PF02204.13 KII62403.1 - 0.019 14.9 0.3 0.066 13.2 0.1 2.0 2 0 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain FlaC_arch PF05377.6 KII62403.1 - 0.59 10.0 6.4 1.5 8.7 0.2 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF4298 PF14131.1 KII62403.1 - 4.6 7.1 9.6 16 5.4 1.5 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4298) DUF3552 PF12072.3 KII62403.1 - 6.3 5.9 17.2 8.7 5.5 2.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) IL15 PF02372.10 KII62405.1 - 1.3 8.8 7.9 2.4 7.9 5.5 1.3 1 0 0 1 1 1 0 Interleukin 15 DUF3407 PF11887.3 KII62406.1 - 0.03 13.5 0.0 0.031 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3407) DUF4496 PF14908.1 KII62408.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4496) GRAM PF02893.15 KII62408.1 - 0.21 11.1 1.6 0.8 9.2 0.3 2.3 2 1 0 2 2 2 0 GRAM domain TENA_THI-4 PF03070.11 KII62410.1 - 0.0045 16.7 0.5 0.82 9.3 0.0 2.1 1 1 1 2 2 2 2 TENA/THI-4/PQQC family Rapsyn_N PF10579.4 KII62410.1 - 0.035 13.8 0.3 0.24 11.2 0.2 2.1 2 0 0 2 2 2 0 Rapsyn N-terminal myristoylation and linker region DUF3137 PF11335.3 KII62410.1 - 0.11 12.1 0.2 0.18 11.4 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3137) DUF4251 PF14059.1 KII62411.1 - 0.029 14.1 0.1 0.07 12.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4251) mRNA_cap_enzyme PF01331.14 KII62411.1 - 0.033 13.8 1.0 0.037 13.7 0.1 1.6 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain rve PF00665.21 KII62412.1 - 0.016 15.3 0.2 0.29 11.2 0.0 2.3 1 1 1 2 2 2 0 Integrase core domain MIS13 PF08202.6 KII62412.1 - 0.039 13.0 0.3 0.04 12.9 0.2 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family DUF3581 PF12119.3 KII62415.1 - 0.048 12.8 0.0 0.057 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3581) Meth_synt_1 PF08267.7 KII62416.1 - 0.1 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Cobalamin-independent synthase, N-terminal domain Ufm1 PF03671.9 KII62417.1 - 0.072 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fold modifier 1 protein Ribosomal_S19e PF01090.14 KII62418.1 - 7.7e-44 148.5 0.0 8.8e-44 148.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e AAA PF00004.24 KII62420.1 - 2.2e-43 147.6 0.0 3.1e-43 147.1 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KII62420.1 - 1.1e-07 31.6 0.1 4.2e-07 29.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KII62420.1 - 1.8e-07 31.3 0.2 1.7e-06 28.1 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 KII62420.1 - 2.7e-07 30.6 0.0 5.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KII62420.1 - 2.7e-06 27.5 0.4 8.6e-05 22.6 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII62420.1 - 2.2e-05 25.2 0.0 3.9e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII62420.1 - 2.8e-05 23.8 0.0 4.9e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 KII62420.1 - 3.2e-05 23.0 0.0 5.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KII62420.1 - 0.00011 22.0 0.0 0.00028 20.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 KII62420.1 - 0.00018 20.3 0.0 0.00026 19.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 KII62420.1 - 0.00024 20.5 0.0 0.00037 19.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 KII62420.1 - 0.0011 18.1 0.0 0.0016 17.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.1 KII62420.1 - 0.0011 18.8 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 KII62420.1 - 0.0012 18.0 0.3 0.031 13.4 0.0 2.6 1 1 1 3 3 3 1 PhoH-like protein AAA_3 PF07726.6 KII62420.1 - 0.0015 18.1 0.0 0.0027 17.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 KII62420.1 - 0.0033 17.7 0.0 0.0047 17.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 KII62420.1 - 0.0047 16.4 0.3 0.029 13.8 0.0 2.4 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.1 KII62420.1 - 0.0058 16.6 0.0 0.0086 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KII62420.1 - 0.0076 15.4 0.2 0.02 14.0 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KII62420.1 - 0.01 15.2 0.2 0.18 11.1 0.0 2.1 1 1 1 2 2 2 0 AAA domain NACHT PF05729.7 KII62420.1 - 0.011 15.4 0.1 0.12 12.0 0.0 2.1 2 0 0 2 2 2 0 NACHT domain KaiC PF06745.8 KII62420.1 - 0.014 14.4 0.0 0.04 13.0 0.0 1.7 2 0 0 2 2 2 0 KaiC ResIII PF04851.10 KII62420.1 - 0.016 15.0 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NB-ARC PF00931.17 KII62420.1 - 0.019 13.8 0.0 0.03 13.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activ_2 PF14532.1 KII62420.1 - 0.026 14.5 0.0 0.09 12.8 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_11 PF13086.1 KII62420.1 - 0.037 13.6 0.0 0.045 13.3 0.0 1.3 1 1 0 1 1 1 0 AAA domain Torsin PF06309.6 KII62420.1 - 0.039 13.8 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 Torsin RNA_helicase PF00910.17 KII62420.1 - 0.072 13.2 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.12 KII62420.1 - 0.08 11.7 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.1 KII62420.1 - 0.086 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain SFTA2 PF15210.1 KII62420.1 - 0.089 12.3 0.7 0.29 10.7 0.4 1.9 3 0 0 3 3 1 0 Surfactant-associated protein 2 DUF815 PF05673.8 KII62420.1 - 0.12 11.2 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 KII62420.1 - 0.13 12.5 0.0 0.24 11.6 0.0 1.6 1 1 0 1 1 1 0 ABC transporter DUF2075 PF09848.4 KII62420.1 - 0.15 10.9 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) UCH PF00443.24 KII62421.1 - 2.2e-13 49.9 0.3 3.5e-13 49.2 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 KII62421.1 - 0.031 14.3 4.7 0.076 13.1 2.7 2.1 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 KII62421.1 - 0.2 11.0 2.5 0.31 10.4 1.7 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PCI PF01399.22 KII62422.1 - 0.00055 20.2 1.4 0.0009 19.5 0.3 1.8 2 0 0 2 2 2 1 PCI domain Peptidase_M1 PF01433.15 KII62424.1 - 0.0001 21.5 0.0 0.00088 18.4 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M1 Serpin PF00079.15 KII62425.1 - 1.6e-35 122.9 5.6 1.8e-35 122.7 3.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) NMT PF01233.14 KII62425.1 - 0.065 12.8 1.3 0.089 12.4 0.2 1.8 2 0 0 2 2 2 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain DUF2930 PF11152.3 KII62426.1 - 0.0096 15.1 0.6 2.3 7.3 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2930) Ribosomal_S19e PF01090.14 KII62427.1 - 7.4e-45 151.8 0.0 8.4e-45 151.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e E1-E2_ATPase PF00122.15 KII62428.1 - 6.5e-11 41.6 0.0 6.5e-11 41.6 0.0 2.2 3 0 0 3 3 3 1 E1-E2 ATPase HAD PF12710.2 KII62429.1 - 2.2e-18 67.1 0.0 3.4e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KII62429.1 - 6.1e-18 66.0 0.0 3.7e-17 63.4 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII62429.1 - 4.6e-05 23.3 0.0 9.4e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KII62429.1 - 0.03 13.9 0.1 0.11 12.0 0.1 2.0 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Neur_chan_memb PF02932.11 KII62430.1 - 0.012 15.4 0.8 0.012 15.4 0.6 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_L23eN PF03939.8 KII62432.1 - 3.9e-13 49.2 11.1 3.9e-13 49.2 7.7 3.4 2 1 1 3 3 3 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.15 KII62432.1 - 5.3e-13 48.7 2.4 5.3e-13 48.7 1.7 2.7 2 1 0 2 2 2 1 Ribosomal protein L23 Synaphin PF05835.7 KII62432.1 - 0.0064 16.6 5.0 0.0084 16.2 3.4 1.2 1 0 0 1 1 1 1 Synaphin protein RRM_1 PF00076.17 KII62433.1 - 1.7e-28 98.0 0.0 4.6e-14 51.7 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII62433.1 - 1.4e-20 73.0 0.0 2.1e-13 50.0 0.0 2.4 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII62433.1 - 9.3e-20 70.2 0.0 3.8e-11 42.6 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII62433.1 - 0.00015 21.4 0.0 0.0036 17.0 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 KII62433.1 - 0.015 15.0 0.0 1 9.1 0.0 2.7 2 1 1 3 3 3 0 Limkain b1 RRM_3 PF08777.6 KII62433.1 - 0.12 12.2 0.0 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif FLYWCH PF04500.11 KII62434.1 - 1.7e-07 30.9 1.1 3e-07 30.2 0.8 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain DUF2365 PF10157.4 KII62434.1 - 0.1 12.5 0.6 4.9 7.0 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2365) SSrecog PF03531.9 KII62435.1 - 0.14 11.5 0.3 0.17 11.1 0.2 1.1 1 0 0 1 1 1 0 Structure-specific recognition protein (SSRP1) MULE PF10551.4 KII62435.1 - 0.14 12.3 0.1 0.29 11.3 0.1 1.6 1 0 0 1 1 1 0 MULE transposase domain Ras PF00071.17 KII62436.1 - 3.5e-61 205.3 0.3 4.2e-61 205.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII62436.1 - 2.2e-19 70.1 0.1 4e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII62436.1 - 2.3e-12 46.5 0.2 3.3e-12 45.9 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KII62436.1 - 3.3e-07 30.2 0.1 5.6e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KII62436.1 - 0.0002 20.8 0.2 0.00066 19.1 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 KII62436.1 - 0.0003 20.9 0.1 0.00099 19.2 0.0 1.8 1 1 1 2 2 2 1 AAA domain PduV-EutP PF10662.4 KII62436.1 - 0.00037 20.0 0.0 0.00063 19.2 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.7 KII62436.1 - 0.00099 18.3 0.1 0.0014 17.8 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.11 KII62436.1 - 0.004 16.3 0.1 0.0089 15.2 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 KII62436.1 - 0.015 15.2 0.1 0.062 13.2 0.1 1.9 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.1 KII62436.1 - 0.015 15.3 0.2 0.033 14.1 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.5 KII62436.1 - 0.015 14.5 0.0 0.021 14.0 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.22 KII62436.1 - 0.025 14.8 0.2 0.036 14.3 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.1 KII62436.1 - 0.038 13.9 0.1 0.83 9.5 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_15 PF13175.1 KII62436.1 - 0.047 12.7 0.0 0.052 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.10 KII62436.1 - 0.076 12.7 0.1 0.14 11.8 0.1 1.5 1 1 0 1 1 1 0 NTPase AAA_29 PF13555.1 KII62436.1 - 0.12 11.8 0.0 0.38 10.3 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AMP-binding PF00501.23 KII62437.1 - 8.1e-74 248.4 0.0 9.6e-74 248.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Syja_N PF02383.13 KII62437.1 - 0.048 12.4 0.2 0.079 11.7 0.1 1.2 1 0 0 1 1 1 0 SacI homology domain Ribosomal_S6 PF01250.12 KII62438.1 - 2.5e-05 24.0 0.0 3e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 Phosphodiest PF01663.17 KII62439.1 - 8e-50 170.1 4.4 5.5e-49 167.4 3.1 1.8 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PglZ PF08665.7 KII62439.1 - 0.0002 21.1 0.0 0.00036 20.2 0.0 1.4 1 0 0 1 1 1 1 PglZ domain DDE_3 PF13358.1 KII62440.1 - 1.1e-09 38.1 0.2 2e-09 37.3 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Med27 PF11571.3 KII62440.1 - 0.024 14.7 0.4 0.043 13.9 0.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 27 DUF1798 PF08807.5 KII62440.1 - 0.034 13.8 0.4 0.094 12.4 0.1 1.6 2 0 0 2 2 2 0 Bacterial domain of unknown function (DUF1798) BAR PF03114.13 KII62443.1 - 0.11 12.0 0.3 0.13 11.7 0.2 1.1 1 0 0 1 1 1 0 BAR domain Aldedh PF00171.17 KII62444.1 - 1.8e-83 280.4 0.0 2.1e-83 280.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Lipoprotein_9 PF03180.9 KII62444.1 - 0.045 12.6 0.0 0.53 9.1 0.0 2.2 2 0 0 2 2 2 0 NLPA lipoprotein DUF1464 PF07318.7 KII62445.1 - 0.07 11.9 0.0 0.079 11.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) MULE PF10551.4 KII62446.1 - 1.5e-06 28.2 0.0 6.6e-06 26.2 0.0 2.1 2 1 0 2 2 2 1 MULE transposase domain FLYWCH PF04500.11 KII62446.1 - 3.4e-05 23.6 0.1 8.9e-05 22.2 0.1 1.8 1 0 0 1 1 1 1 FLYWCH zinc finger domain Imm47 PF15586.1 KII62446.1 - 0.012 15.4 0.1 0.036 13.9 0.0 1.8 2 0 0 2 2 2 0 Immunity protein 47 ERAP1_C PF11838.3 KII62447.1 - 7e-24 84.6 1.5 4.5e-23 82.0 1.1 2.0 1 1 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.15 KII62448.1 - 5.1e-25 88.3 0.6 6.3e-25 88.0 0.4 1.1 1 0 0 1 1 1 1 Peptidase family M1 Peptidase_MA_2 PF13485.1 KII62448.1 - 1.1e-07 31.9 0.0 1.3e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M1 PF01433.15 KII62449.1 - 2.8e-70 237.3 2.4 4.1e-70 236.8 1.6 1.2 1 0 0 1 1 1 1 Peptidase family M1 WLM PF08325.5 KII62449.1 - 0.14 11.9 0.1 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 WLM domain DDE_3 PF13358.1 KII62452.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease AIRS_C PF02769.17 KII62454.1 - 8.7e-22 77.7 0.0 1.2e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 KII62454.1 - 0.0006 20.0 0.2 0.0012 18.9 0.1 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain DDE_Tnp_IS1595 PF12762.2 KII62455.1 - 1.3e-16 60.7 0.0 1.7e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain eIF3_N PF09440.5 KII62456.1 - 4.9e-08 33.2 0.5 1.1e-07 32.0 0.3 1.6 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain FLYWCH PF04500.11 KII62458.1 - 2.9e-09 36.6 3.0 7.9e-09 35.2 2.1 1.8 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 KII62458.1 - 2.9e-06 27.3 0.4 6.7e-06 26.1 0.3 1.6 1 0 0 1 1 1 1 MULE transposase domain MULE PF10551.4 KII62460.1 - 3e-05 24.0 0.0 6.7e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain H_lectin PF09458.5 KII62460.1 - 0.044 13.4 0.1 0.12 12.0 0.1 1.7 1 0 0 1 1 1 0 H-type lectin domain UcrQ PF02939.11 KII62461.1 - 0.0035 17.1 0.3 0.005 16.6 0.2 1.4 1 1 0 1 1 1 1 UcrQ family Serpin PF00079.15 KII62462.1 - 1.8e-38 132.6 0.0 3.1e-38 131.8 0.0 1.3 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Exo70 PF03081.10 KII62463.1 - 0.031 13.0 0.2 0.054 12.2 0.1 1.4 1 1 0 1 1 1 0 Exo70 exocyst complex subunit Peptidase_C78 PF07910.8 KII62466.1 - 1.8e-45 154.7 0.5 3.2e-45 153.9 0.3 1.4 1 0 0 1 1 1 1 Peptidase family C78 Ribosomal_S5_C PF03719.10 KII62467.1 - 2.2e-22 78.1 0.5 3.5e-22 77.4 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 KII62467.1 - 1.1e-21 76.3 1.6 2.1e-21 75.3 1.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain APS_kinase PF01583.15 KII62468.1 - 5.2e-28 97.6 0.0 6.8e-28 97.2 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 KII62468.1 - 0.00024 21.0 0.1 0.0016 18.3 0.0 1.8 1 1 1 2 2 2 1 AAA domain KTI12 PF08433.5 KII62468.1 - 0.0011 18.2 0.0 0.0018 17.5 0.0 1.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 KII62468.1 - 0.0093 15.0 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 KII62468.1 - 0.0094 16.7 0.0 0.011 16.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII62468.1 - 0.024 14.9 0.0 0.031 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain CPT PF07931.7 KII62468.1 - 0.12 11.9 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ATP-sulfurylase PF01747.12 KII62469.1 - 1.8e-55 187.5 0.0 2e-55 187.4 0.0 1.0 1 0 0 1 1 1 1 ATP-sulfurylase DUF1279 PF06916.8 KII62470.1 - 0.00048 20.3 3.5 0.001 19.3 2.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) BolA PF01722.13 KII62472.1 - 1.4e-22 79.4 0.1 1.8e-22 79.0 0.1 1.1 1 0 0 1 1 1 1 BolA-like protein zf-HIT PF04438.11 KII62474.1 - 2e-07 30.5 15.4 5.7e-07 29.0 10.6 1.8 1 0 0 1 1 1 1 HIT zinc finger DCP2 PF05026.8 KII62474.1 - 0.02 14.7 0.3 0.93 9.4 0.0 3.1 1 1 0 2 2 2 0 Dcp2, box A domain zf-Mss51 PF13824.1 KII62474.1 - 0.27 11.1 8.3 0.66 9.8 5.7 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 DUF329 PF03884.9 KII62474.1 - 0.37 10.3 8.3 0.87 9.1 5.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF329) DEAD PF00270.24 KII62476.1 - 2.8e-11 43.2 0.0 4.8e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII62477.1 - 2.6e-12 46.4 0.1 5.4e-12 45.3 0.1 1.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Cys_Met_Meta_PP PF01053.15 KII62477.1 - 0.077 11.2 0.0 0.11 10.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF1493 PF07377.7 KII62479.1 - 0.012 15.7 0.2 0.015 15.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) BNR PF02012.15 KII62480.1 - 0.00078 18.9 4.5 0.36 10.8 0.1 3.6 3 0 0 3 3 3 3 BNR/Asp-box repeat COOH-NH2_lig PF14395.1 KII62483.1 - 0.094 11.7 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Phage phiEco32-like COOH.NH2 ligase-type 2 BNR PF02012.15 KII62486.1 - 6.4e-05 22.2 5.1 0.55 10.2 0.0 3.8 3 0 0 3 3 3 3 BNR/Asp-box repeat DUF1792 PF08759.6 KII62488.1 - 0.04 13.5 0.0 0.045 13.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1792) SNAP PF14938.1 KII62489.1 - 1.4e-36 126.1 17.1 1.6e-36 125.9 11.9 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.1 KII62489.1 - 0.071 13.6 5.2 11 6.6 0.0 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KII62489.1 - 0.15 11.9 10.7 1.5 8.7 1.3 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 KII62489.1 - 0.21 12.2 8.3 1.5 9.6 0.2 4.1 4 1 0 4 4 4 0 Sel1 repeat FliS PF02561.9 KII62490.1 - 0.0033 17.2 2.3 0.78 9.5 0.2 2.3 1 1 1 2 2 2 2 Flagellar protein FliS E1_DerP2_DerF2 PF02221.10 KII62492.1 - 3.5e-09 37.0 0.7 3.9e-09 36.8 0.5 1.0 1 0 0 1 1 1 1 ML domain Stanniocalcin PF03298.8 KII62492.1 - 0.052 12.5 0.2 0.07 12.1 0.1 1.2 1 0 0 1 1 1 0 Stanniocalcin family RVT_1 PF00078.22 KII62494.1 - 1.8e-07 30.7 0.0 2.3e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LAP2alpha PF11560.3 KII62495.1 - 0.0058 15.8 0.0 0.007 15.5 0.0 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 2 alpha Cyclase_polyket PF04673.7 KII62497.1 - 0.013 15.5 0.6 0.27 11.2 0.0 2.3 2 0 0 2 2 2 0 Polyketide synthesis cyclase COX16 PF14138.1 KII62497.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 HTH_28 PF13518.1 KII62499.1 - 0.00047 20.0 0.0 0.00084 19.2 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 KII62499.1 - 0.00057 19.4 0.0 0.00096 18.7 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Crp_2 PF13545.1 KII62499.1 - 0.13 12.1 0.1 0.33 10.7 0.0 1.7 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain DUF3115 PF11312.3 KII62502.1 - 0.16 10.7 0.2 2.4 6.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3115) LLC1 PF14945.1 KII62503.1 - 0.003 17.8 2.1 0.003 17.8 1.5 1.9 1 1 1 2 2 2 1 Normal lung function maintenance, Low in Lung Cancer 1 protein gag-asp_proteas PF13975.1 KII62503.1 - 0.02 14.7 0.0 0.055 13.3 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII62503.1 - 0.03 14.8 0.0 0.11 12.9 0.0 2.0 1 0 0 1 1 1 0 Aspartyl protease DUF2200 PF09966.4 KII62503.1 - 0.091 12.6 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) Peptidase_M27 PF01742.12 KII62504.1 - 0.083 11.7 0.3 0.12 11.2 0.2 1.1 1 0 0 1 1 1 0 Clostridial neurotoxin zinc protease zf-CCHC_2 PF13696.1 KII62506.1 - 0.021 14.3 1.4 0.037 13.5 0.9 1.3 1 0 0 1 1 1 0 Zinc knuckle eIF3g PF12353.3 KII62506.1 - 0.26 11.1 5.8 1.1 9.1 0.1 2.5 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.18 KII62506.1 - 1.7 8.7 7.2 0.37 10.8 1.2 2.3 2 0 0 2 2 2 0 Zinc knuckle FtsL PF04999.8 KII62509.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Cell division protein FtsL TPR_8 PF13181.1 KII62509.1 - 0.062 13.1 0.3 0.3 10.9 0.2 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DDE_1 PF03184.14 KII62516.1 - 1.1e-05 24.7 0.0 1.3e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.1 KII62517.1 - 3.9e-08 32.7 0.3 6.9e-08 31.9 0.2 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DegS PF05384.6 KII62517.1 - 0.067 12.3 2.5 0.69 9.1 0.8 2.6 2 1 0 2 2 2 0 Sensor protein DegS SNAP PF14938.1 KII62518.1 - 1.4e-06 27.6 5.6 2.1e-06 27.0 3.9 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DegS PF05384.6 KII62518.1 - 0.016 14.4 0.9 1.8 7.7 0.0 2.6 2 1 1 3 3 3 0 Sensor protein DegS DUF1091 PF06477.8 KII62518.1 - 0.022 15.2 0.6 0.036 14.5 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1091) RhoGAP PF00620.22 KII62518.1 - 0.086 12.4 1.0 1.1 8.8 0.2 2.0 2 0 0 2 2 2 0 RhoGAP domain TPR_2 PF07719.12 KII62518.1 - 0.83 9.7 6.3 5.8 7.0 0.2 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 KII62518.1 - 1.1 9.3 14.4 0.53 10.4 1.8 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3276 PF11680.3 KII62518.1 - 2.3 8.0 7.9 0.42 10.4 0.6 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3276) Phage_Gp14 PF10666.4 KII62518.1 - 6.7 6.5 11.1 3.2 7.6 0.6 2.9 1 1 1 3 3 3 0 Phage protein Gp14 TPR_1 PF00515.23 KII62518.1 - 6.8 6.4 7.4 13 5.6 0.3 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF1730 PF08331.5 KII62519.1 - 0.014 15.0 0.6 0.36 10.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1730) RNA_POL_M_15KD PF02150.11 KII62519.1 - 0.14 11.8 0.2 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit Glycophorin_A PF01102.13 KII62520.1 - 0.001 18.8 0.1 0.0014 18.3 0.1 1.3 1 0 0 1 1 1 1 Glycophorin A NS3_envE PF02723.9 KII62520.1 - 0.0011 18.7 7.8 0.0025 17.6 5.4 1.6 1 0 0 1 1 1 1 Non-structural protein NS3/Small envelope protein E Shisa PF13908.1 KII62520.1 - 0.0041 17.3 11.1 0.0041 17.3 7.7 1.6 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.1 KII62520.1 - 0.0046 16.6 5.7 0.0063 16.2 4.0 1.1 1 0 0 1 1 1 1 TMEM154 protein family NAD4L PF06235.6 KII62520.1 - 0.012 15.3 6.5 0.022 14.5 4.5 1.5 1 0 0 1 1 1 0 NADH dehydrogenase subunit 4L (NAD4L) EphA2_TM PF14575.1 KII62520.1 - 0.025 14.9 1.8 0.046 14.1 1.2 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Herpes_gE PF02480.11 KII62520.1 - 0.037 12.3 2.4 0.048 11.9 1.7 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Sarcoglycan_2 PF05510.8 KII62520.1 - 0.1 10.9 1.0 0.13 10.5 0.7 1.1 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon IncA PF04156.9 KII62520.1 - 0.11 12.0 3.4 0.19 11.3 2.4 1.2 1 0 0 1 1 1 0 IncA protein DUF3481 PF11980.3 KII62520.1 - 0.12 12.1 0.7 0.22 11.3 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3481) Adeno_E3_CR2 PF02439.10 KII62520.1 - 0.18 11.3 17.8 0.38 10.3 12.3 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SP_C-Propep PF08999.5 KII62520.1 - 0.19 11.2 3.1 0.31 10.5 2.1 1.5 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide EzrA PF06160.7 KII62520.1 - 0.26 9.4 0.8 0.33 9.0 0.6 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Protocadherin PF08374.6 KII62520.1 - 0.32 10.6 3.3 0.47 10.0 2.3 1.2 1 0 0 1 1 1 0 Protocadherin RCR PF12273.3 KII62520.1 - 0.53 10.8 7.0 0.82 10.2 4.9 1.4 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Rifin_STEVOR PF02009.11 KII62520.1 - 1.2 8.7 8.7 1.5 8.4 6.0 1.1 1 0 0 1 1 1 0 Rifin/stevor family CD34_antigen PF06365.7 KII62520.1 - 1.2 8.7 4.2 1.6 8.3 2.9 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Rhabdo_glycop PF00974.13 KII62520.1 - 2.2 6.3 6.7 3.6 5.7 4.6 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein DUF912 PF06024.7 KII62520.1 - 3 7.9 5.1 4.4 7.4 3.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) LRRC37AB_C PF14914.1 KII62520.1 - 4.8 6.6 6.9 6.8 6.1 4.8 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain UPF0560 PF10577.4 KII62520.1 - 5.6 5.0 7.0 7.3 4.7 4.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DAG1 PF05454.6 KII62520.1 - 7 5.7 6.5 10 5.2 4.5 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) SNAP PF14938.1 KII62521.1 - 9.8e-11 41.3 10.5 1.5e-10 40.7 7.3 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NSF PF02071.15 KII62521.1 - 1.5 9.7 9.3 5.1 8.1 0.1 4.0 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat SIT PF15330.1 KII62522.1 - 0.0019 18.2 0.0 0.0028 17.7 0.0 1.3 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT PspB PF06667.7 KII62522.1 - 0.0033 17.3 0.0 0.012 15.4 0.0 1.8 2 0 0 2 2 2 1 Phage shock protein B DUF1510 PF07423.6 KII62522.1 - 0.018 14.4 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TMEM154 PF15102.1 KII62522.1 - 0.052 13.2 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Foamy_virus_ENV PF03408.9 KII62522.1 - 0.059 10.9 0.1 0.066 10.7 0.0 1.2 1 0 0 1 1 1 0 Foamy virus envelope protein Amnionless PF14828.1 KII62522.1 - 0.51 8.7 18.3 0.2 10.1 9.6 1.9 1 1 1 2 2 2 0 Amnionless ASFV_J13L PF05568.6 KII62523.1 - 0.02 14.4 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein CD34_antigen PF06365.7 KII62523.1 - 0.056 13.1 0.1 0.067 12.8 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family ODV-E18 PF10717.4 KII62523.1 - 0.075 12.4 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 TMEM117 PF15113.1 KII62523.1 - 0.081 11.5 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 TMEM117 protein family Adeno_E3_14_5 PF04834.7 KII62523.1 - 0.098 13.0 2.0 0.17 12.2 1.4 1.6 1 1 0 1 1 1 0 Early E3 14.5 kDa protein EphA2_TM PF14575.1 KII62523.1 - 0.1 13.0 0.2 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.6 KII62523.1 - 0.69 9.3 4.5 0.17 11.2 0.7 1.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family Viral_Beta_CD PF04530.7 KII62523.1 - 6 7.0 8.8 17 5.5 6.1 1.8 1 1 0 1 1 1 0 Viral Beta C/D like family DUF912 PF06024.7 KII62523.1 - 7.6 6.6 5.6 0.52 10.3 0.1 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) WTF PF03303.8 KII62524.1 - 0.0049 16.3 0.4 0.0062 15.9 0.3 1.2 1 0 0 1 1 1 1 WTF protein DUF3079 PF11278.3 KII62524.1 - 0.01 15.3 2.9 0.01 15.3 2.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3079) CD34_antigen PF06365.7 KII62524.1 - 0.019 14.6 1.5 0.023 14.3 0.9 1.4 1 1 0 1 1 1 0 CD34/Podocalyxin family DUF2985 PF11204.3 KII62524.1 - 0.029 14.1 0.1 0.044 13.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) MMS19_C PF12460.3 KII62526.1 - 0.00052 18.8 0.7 0.0089 14.7 0.2 2.2 2 1 0 2 2 2 2 RNAPII transcription regulator C-terminal Arm PF00514.18 KII62526.1 - 0.084 12.7 0.0 4.4 7.2 0.0 3.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KII62527.1 - 3.7e-11 42.1 3.7 5.9e-05 22.8 0.0 5.6 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.1 KII62527.1 - 2.3e-09 37.4 0.1 0.00016 22.0 0.0 4.2 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.1 KII62527.1 - 8.9e-07 29.1 0.0 0.00096 19.3 0.0 3.3 1 1 3 4 4 4 2 HEAT repeats DUF2435 PF10363.4 KII62527.1 - 0.0044 16.8 0.0 0.12 12.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2435) Adaptin_N PF01602.15 KII62527.1 - 0.023 13.0 1.7 2.3 6.4 0.1 2.2 2 0 0 2 2 2 0 Adaptin N terminal region Arm PF00514.18 KII62527.1 - 0.023 14.4 0.1 28 4.7 0.0 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat UBN2 PF14223.1 KII62528.1 - 7.6e-05 22.4 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type RVT_1 PF00078.22 KII62528.1 - 9.5e-05 21.8 0.0 0.00021 20.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII62528.1 - 0.00041 20.2 0.0 0.00088 19.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII62528.1 - 0.00051 19.7 12.8 0.025 14.3 1.3 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.18 KII62528.1 - 0.001 18.8 14.6 0.031 14.2 2.2 2.6 2 0 0 2 2 2 2 Zinc knuckle Peptidase_A2E PF12382.3 KII62528.1 - 0.0068 16.2 0.3 0.012 15.3 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon peptidase Asp_protease_2 PF13650.1 KII62528.1 - 0.031 14.7 0.0 0.065 13.7 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease RVT_1 PF00078.22 KII62529.1 - 5.8e-12 45.4 0.1 8.1e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF239 PF03080.10 KII62530.1 - 0.015 14.4 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF239) DDE_3 PF13358.1 KII62531.1 - 1.3e-07 31.4 0.7 7.1e-07 29.0 0.1 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease Poxvirus_B22R_C PF13168.1 KII62531.1 - 0.00085 18.6 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Poxvirus B22R protein C-terminal GNVR PF13807.1 KII62534.1 - 0.059 13.1 0.1 0.14 11.9 0.0 1.7 1 1 0 1 1 1 0 G-rich domain on putative tyrosine kinase MRAP PF15183.1 KII62534.1 - 0.12 12.0 0.2 17 5.0 0.0 2.3 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family DUF4371 PF14291.1 KII62535.1 - 0.0038 16.8 0.4 0.041 13.4 0.1 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4371) NIPSNAP PF07978.8 KII62536.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 NIPSNAP Pro_isomerase PF00160.16 KII62537.1 - 5e-36 124.2 2.3 5.7e-36 124.0 1.6 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Transketolase_C PF02780.15 KII62538.1 - 8.3e-42 142.0 0.1 2.2e-41 140.6 0.0 1.6 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transket_pyr PF02779.19 KII62538.1 - 2e-14 53.4 0.0 3.1e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DUF4371 PF14291.1 KII62539.1 - 9.8e-12 44.9 2.1 1.3e-11 44.5 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.9 KII62539.1 - 3.6e-06 26.5 0.1 9.2e-06 25.2 0.1 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Med9 PF07544.8 KII62539.1 - 0.78 9.5 4.2 1.3 8.7 0.0 3.1 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 PolyA_pol PF01743.15 KII62540.1 - 0.38 10.9 2.3 0.75 10.0 1.6 1.7 1 1 0 1 1 1 0 Poly A polymerase head domain MULE PF10551.4 KII62541.1 - 1.1e-06 28.7 0.0 2.5e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.13 KII62541.1 - 0.00034 19.3 0.5 0.00096 17.8 0.3 1.7 1 1 0 1 1 1 1 Transposase, Mutator family Complex1_LYR PF05347.10 KII62542.1 - 2.9 7.7 6.4 7.8 6.3 3.2 2.4 2 1 0 2 2 2 0 Complex 1 protein (LYR family) Mago_nashi PF02792.9 KII62544.1 - 0.0034 17.0 0.3 0.027 14.1 0.0 2.0 1 1 1 2 2 2 1 Mago nashi protein DUF1929 PF09118.6 KII62545.1 - 0.08 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1929) Rad51 PF08423.6 KII62545.1 - 0.1 11.5 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Rad51 Serpin PF00079.15 KII62546.1 - 9.4e-28 97.3 0.5 1.1e-27 97.1 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.1 KII62548.1 - 3.7e-06 26.3 1.2 5.3e-06 25.7 0.8 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Cactin_mid PF10312.4 KII62548.1 - 0.012 14.8 0.3 0.036 13.3 0.0 1.8 2 0 0 2 2 2 0 Conserved mid region of cactin NMT_C PF02799.10 KII62548.1 - 0.057 12.7 1.4 0.098 12.0 0.6 1.6 1 1 1 2 2 2 0 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain SNAP PF14938.1 KII62550.1 - 5.1e-05 22.5 0.2 6.5e-05 22.2 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF3305 PF11749.3 KII62552.1 - 0.086 12.7 0.1 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3305) S-AdoMet_synt_M PF02772.11 KII62552.1 - 0.11 12.4 0.8 0.28 11.1 0.3 1.9 1 1 1 2 2 2 0 S-adenosylmethionine synthetase, central domain rve PF00665.21 KII62553.1 - 7.2e-12 45.4 0.0 1.2e-11 44.7 0.0 1.4 1 1 0 1 1 1 1 Integrase core domain HTH_33 PF13592.1 KII62555.1 - 0.0013 18.2 0.0 0.0032 16.9 0.0 1.7 1 1 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII62555.1 - 0.026 14.5 0.0 0.53 10.3 0.0 2.1 2 0 0 2 2 2 0 Transposase Peptidase_S8 PF00082.17 KII62556.1 - 9.4e-26 90.5 1.1 1.5e-25 89.8 0.8 1.3 1 1 0 1 1 1 1 Subtilase family DUF108 PF01958.13 KII62556.1 - 0.13 12.5 0.1 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF108 rve PF00665.21 KII62558.1 - 3.8e-18 65.7 0.0 5.1e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62558.1 - 0.00017 21.0 0.1 0.0003 20.2 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain RestrictionMunI PF11407.3 KII62558.1 - 0.092 12.3 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Type II restriction enzyme MunI Bac_export_2 PF01312.14 KII62559.1 - 0.021 13.7 0.0 0.034 13.0 0.0 1.3 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family rve PF00665.21 KII62560.1 - 3.8e-18 65.7 0.0 5.1e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62560.1 - 0.00017 21.0 0.1 0.0003 20.2 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain RestrictionMunI PF11407.3 KII62560.1 - 0.092 12.3 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Type II restriction enzyme MunI Bac_export_2 PF01312.14 KII62561.1 - 0.012 14.5 0.0 0.017 14.0 0.0 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family DUF2573 PF10835.3 KII62561.1 - 1.3 9.0 4.0 1.6 8.7 0.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2573) Arm PF00514.18 KII62563.1 - 6.4e-21 73.3 2.1 0.033 14.0 0.0 8.4 8 1 0 8 8 8 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KII62563.1 - 4.7e-06 26.8 0.0 1.4 9.2 0.0 4.6 2 2 3 5 5 5 4 HEAT repeats Proteasom_PSMB PF10508.4 KII62563.1 - 3.4e-05 22.3 2.4 0.00018 19.9 0.2 2.5 1 1 1 3 3 3 2 Proteasome non-ATPase 26S subunit HEAT_EZ PF13513.1 KII62563.1 - 0.00056 20.3 0.0 7.4 7.1 0.0 4.0 3 0 0 3 3 3 2 HEAT-like repeat DDE_Tnp_IS1595 PF12762.2 KII62564.1 - 0.033 14.0 0.5 0.14 11.9 0.2 2.0 1 1 1 2 2 2 0 ISXO2-like transposase domain Ldl_recept_a PF00057.13 KII62565.1 - 3.2e-05 23.7 14.1 3.2e-05 23.7 9.8 3.0 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A DDE_1 PF03184.14 KII62569.1 - 1.4e-09 37.3 0.1 1.7e-09 37.1 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.1 KII62570.1 - 5.9e-14 51.8 2.9 8.1e-14 51.4 2.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.1 KII62570.1 - 0.0039 16.8 0.5 0.0039 16.8 0.4 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII62570.1 - 0.0052 16.6 11.8 0.16 11.9 0.3 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 KII62570.1 - 0.0056 16.3 6.3 0.51 10.2 0.1 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 KII62570.1 - 0.0061 16.4 4.0 0.12 12.2 0.0 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KII62570.1 - 0.0067 16.9 0.9 4.6 8.1 0.0 3.6 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII62570.1 - 0.0094 15.5 0.4 0.0094 15.5 0.3 4.0 5 0 0 5 5 5 1 Tetratricopeptide repeat PPR PF01535.15 KII62570.1 - 0.0096 15.8 2.2 14 5.8 0.1 4.2 4 0 0 4 4 4 0 PPR repeat TPR_16 PF13432.1 KII62570.1 - 0.011 16.4 2.7 1.2 9.9 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 KII62570.1 - 0.035 14.4 1.4 16 5.9 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-DBF PF07535.7 KII62570.1 - 0.065 12.9 0.3 0.17 11.5 0.2 1.8 1 1 0 1 1 1 0 DBF zinc finger DUF3986 PF13143.1 KII62570.1 - 0.087 13.2 1.0 0.19 12.2 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3986) ERp29 PF07749.7 KII62570.1 - 0.27 11.8 2.7 0.88 10.2 0.1 2.5 1 1 2 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain TPR_6 PF13174.1 KII62570.1 - 0.48 10.9 2.5 29 5.4 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII62570.1 - 2.7 7.7 10.9 0.68 9.6 0.2 3.7 2 1 1 3 3 3 0 TPR repeat NSF PF02071.15 KII62570.1 - 9.8 7.2 9.1 60 4.9 0.1 4.6 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat Abi_2 PF07751.6 KII62571.1 - 0.12 12.4 3.0 0.21 11.7 2.0 1.6 1 1 0 1 1 1 0 Abi-like protein DUF1469 PF07332.6 KII62576.1 - 0.00084 19.0 0.0 0.00098 18.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1469) Hydrolase_6 PF13344.1 KII62577.1 - 4e-16 58.7 0.0 6.1e-13 48.5 0.0 3.1 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KII62577.1 - 3.4e-12 45.8 0.0 7.7e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 KII62577.1 - 6.3e-10 39.8 0.0 1.1e-09 39.0 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KII62577.1 - 2.6e-05 24.5 0.0 0.0029 17.8 0.0 2.7 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase Lactamase_B_2 PF12706.2 KII62577.1 - 0.001 18.6 0.5 0.058 12.9 0.0 2.7 2 1 1 3 3 3 1 Beta-lactamase superfamily domain MRL1 PF13003.2 KII62578.1 - 0.085 12.6 0.1 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L1 SH2_2 PF14633.1 KII62579.1 - 7.7e-49 165.7 5.1 1e-48 165.3 3.5 1.1 1 0 0 1 1 1 1 SH2 domain SH2 PF00017.19 KII62579.1 - 9.5e-07 28.5 0.1 0.0003 20.5 0.0 2.5 2 0 0 2 2 2 2 SH2 domain S1 PF00575.18 KII62579.1 - 1.3e-06 28.3 0.2 1.3e-06 28.3 0.1 1.8 2 0 0 2 2 2 1 S1 RNA binding domain Dimer_Tnp_hAT PF05699.9 KII62580.1 - 1.4e-07 31.0 0.4 2.8e-07 30.0 0.1 1.7 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Swi3 PF07962.7 KII62583.1 - 9e-10 38.0 0.2 1.4e-09 37.4 0.2 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Cse1 PF08506.5 KII62584.1 - 6.5e-48 163.1 0.1 1.3e-47 162.1 0.1 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.10 KII62584.1 - 1.8e-21 76.0 5.9 2.3e-18 65.7 3.6 2.8 3 1 0 3 3 3 2 CAS/CSE protein, C-terminus PARP_regulatory PF01358.13 KII62585.1 - 0.0051 15.4 0.1 0.0063 15.1 0.0 1.1 1 0 0 1 1 1 1 Poly A polymerase regulatory subunit OATP PF03137.15 KII62586.1 - 5.5e-27 94.0 17.1 1.6e-26 92.5 11.9 1.6 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII62586.1 - 7.3e-09 34.7 9.0 2.3e-08 33.1 6.3 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 KII62586.1 - 0.05 13.0 7.6 0.041 13.3 3.3 2.1 1 1 1 2 2 2 0 Ion channel regulatory protein UNC-93 DUF2371 PF10177.4 KII62586.1 - 0.2 11.5 5.0 2.5 7.9 0.9 2.9 2 1 1 3 3 3 0 Uncharacterised conserved protein (DUF2371) DUF2306 PF10067.4 KII62586.1 - 0.39 10.8 10.7 0.26 11.4 2.3 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2306) FliG_M PF14841.1 KII62587.1 - 0.01 15.8 0.1 0.016 15.2 0.1 1.4 1 0 0 1 1 1 0 FliG middle domain MFS_1 PF07690.11 KII62588.1 - 0.024 13.3 0.0 0.027 13.2 0.0 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily DUF4040 PF13244.1 KII62588.1 - 0.089 12.7 0.4 0.16 11.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) Pro_3_hydrox_C PF05373.6 KII62590.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 1 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal YagB_YeeU_YfjZ PF06154.6 KII62590.1 - 0.14 12.4 0.1 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 YagB/YeeU/YfjZ family MULE PF10551.4 KII62592.1 - 1.4e-09 37.9 0.0 7.3e-09 35.6 0.0 2.1 2 0 0 2 2 2 1 MULE transposase domain UBN2 PF14223.1 KII62594.1 - 0.095 12.4 0.1 0.17 11.6 0.1 1.6 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type SRP54_N PF02881.14 KII62594.1 - 0.19 11.8 1.7 11 6.2 0.0 3.0 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain Exo_endo_phos PF03372.18 KII62596.1 - 1.9e-18 67.2 0.0 2.3e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KII62596.1 - 0.015 14.9 0.0 0.052 13.1 0.0 2.1 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase MFS_2 PF13347.1 KII62598.1 - 3.9e-10 38.7 7.7 5.8e-10 38.1 5.0 1.4 1 1 1 2 2 2 1 MFS/sugar transport protein MFS_1 PF07690.11 KII62598.1 - 0.0021 16.8 5.2 0.0032 16.2 3.4 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1922 PF09082.5 KII62607.1 - 0.13 12.3 0.8 0.21 11.6 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1922) Cmc1 PF08583.5 KII62608.1 - 0.2 11.4 4.5 0.093 12.5 1.6 1.6 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like STAS PF01740.16 KII62610.1 - 0.0085 15.4 0.0 0.034 13.5 0.0 1.9 2 1 0 2 2 2 1 STAS domain DDE_3 PF13358.1 KII62612.1 - 1.6e-07 31.2 0.6 3.3e-07 30.1 0.2 1.6 1 1 1 2 2 2 1 DDE superfamily endonuclease DUF816 PF05674.7 KII62612.1 - 0.013 15.2 1.8 0.055 13.1 0.3 1.9 1 1 1 2 2 2 0 Baculovirus protein of unknown function (DUF816) PurA PF04845.8 KII62613.1 - 5.2e-13 48.6 0.3 1.6e-08 33.9 0.2 2.1 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein YHS PF04945.8 KII62613.1 - 0.012 15.4 0.1 0.44 10.4 0.0 2.5 2 0 0 2 2 2 0 YHS domain DUF3276 PF11680.3 KII62613.1 - 0.087 12.6 3.0 0.67 9.7 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3276) PurA PF04845.8 KII62614.1 - 1.4e-11 43.9 1.2 9.4e-08 31.4 0.4 2.2 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein Clr2 PF10383.4 KII62615.1 - 0.021 14.8 0.0 0.028 14.4 0.0 1.2 1 0 0 1 1 1 0 Transcription-silencing protein Clr2 RVT_1 PF00078.22 KII62619.1 - 0.022 14.1 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.18 KII62619.1 - 0.032 14.1 1.3 0.078 12.9 0.9 1.7 1 0 0 1 1 1 0 Zinc knuckle DDE_Tnp_IS1595 PF12762.2 KII62620.1 - 9.1e-12 45.0 0.0 1.3e-09 38.0 0.0 2.0 1 1 1 2 2 2 2 ISXO2-like transposase domain Tol_Tol_Ttg2 PF05494.7 KII62621.1 - 0.035 13.6 0.0 0.04 13.4 0.0 1.2 1 0 0 1 1 1 0 Toluene tolerance, Ttg2 Aha1_N PF09229.6 KII62621.1 - 0.066 13.0 0.8 0.077 12.8 0.6 1.1 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal Pept_tRNA_hydro PF01195.14 KII62621.1 - 0.11 12.0 0.1 0.14 11.6 0.1 1.1 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase MSA-2c PF12238.3 KII62621.1 - 0.19 11.3 1.6 0.34 10.5 1.1 1.5 1 1 0 1 1 1 0 Merozoite surface antigen 2c SRI PF08236.6 KII62625.1 - 0.0092 15.9 1.8 0.013 15.4 1.3 1.4 1 1 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain DUF2346 PF09803.4 KII62625.1 - 0.034 14.0 0.1 0.046 13.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2346) ICE2 PF08426.5 KII62625.1 - 0.11 11.1 0.1 0.11 11.0 0.1 1.1 1 0 0 1 1 1 0 ICE2 HoxA13_N PF12284.3 KII62625.1 - 0.12 12.5 0.1 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Hox protein A13 N terminal TB2_DP1_HVA22 PF03134.14 KII62626.1 - 0.049 13.3 0.1 0.06 13.0 0.1 1.2 1 0 0 1 1 1 0 TB2/DP1, HVA22 family LLC1 PF14945.1 KII62629.1 - 0.66 10.2 2.3 12 6.2 0.5 2.6 2 1 1 3 3 3 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Adenylsucc_synt PF00709.16 KII62633.1 - 0.099 11.2 0.1 0.11 11.1 0.0 1.0 1 0 0 1 1 1 0 Adenylosuccinate synthetase Glycos_transf_N PF04413.11 KII62637.1 - 0.0011 18.1 0.0 0.0015 17.7 0.0 1.1 1 0 0 1 1 1 1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) p25-alpha PF05517.7 KII62638.1 - 0.038 14.2 0.1 0.065 13.4 0.0 1.4 1 0 0 1 1 1 0 p25-alpha 7tm_7 PF08395.7 KII62640.1 - 0.00065 18.8 0.5 0.0015 17.5 0.3 1.5 1 0 0 1 1 1 1 7tm Chemosensory receptor PPV_E1_C PF00519.12 KII62640.1 - 0.0022 16.6 0.5 0.0028 16.3 0.4 1.2 1 0 0 1 1 1 1 Papillomavirus helicase Bromodomain PF00439.20 KII62640.1 - 0.0095 15.8 0.4 0.027 14.3 0.3 1.8 1 1 0 1 1 1 1 Bromodomain Urb2 PF10441.4 KII62640.1 - 0.031 13.8 1.3 0.042 13.4 0.7 1.5 1 1 0 1 1 1 0 Urb2/Npa2 family DUF1741 PF08427.5 KII62640.1 - 0.034 13.6 2.1 0.35 10.2 1.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1741) DUF1308 PF07000.6 KII62640.1 - 0.076 11.6 0.3 0.12 11.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) HTH_28 PF13518.1 KII62643.1 - 0.0047 16.9 0.0 0.0074 16.2 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Bot1p PF12298.3 KII62643.1 - 0.0081 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein HTH_Tnp_IS630 PF01710.11 KII62643.1 - 0.015 14.9 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Transposase HTH_Tnp_ISL3 PF13542.1 KII62643.1 - 0.032 13.4 0.1 0.055 12.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Toxin_67 PF15545.1 KII62645.1 - 0.14 12.0 0.1 0.29 11.0 0.0 1.5 2 0 0 2 2 2 0 Putative toxin 67 zf-CCHC PF00098.18 KII62650.1 - 6.5e-08 32.1 1.4 1.3e-07 31.1 0.9 1.6 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.12 KII62650.1 - 0.0022 18.0 0.0 0.0059 16.6 0.0 1.7 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC_4 PF14392.1 KII62650.1 - 0.0023 17.5 0.7 0.0056 16.3 0.5 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.1 KII62650.1 - 0.036 13.7 0.2 0.068 12.9 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle PEX-1N PF09262.6 KII62650.1 - 0.15 12.1 0.0 0.52 10.4 0.0 1.8 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal DUF3885 PF13021.1 KII62651.1 - 0.0071 16.0 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3885) HEAT PF02985.17 KII62653.1 - 2.6e-11 42.5 0.2 0.0028 17.6 0.0 8.6 9 0 0 9 9 9 1 HEAT repeat HEAT_2 PF13646.1 KII62653.1 - 0.0011 19.2 0.0 0.66 10.2 0.0 4.7 6 2 0 7 7 7 1 HEAT repeats DUF3437 PF11919.3 KII62653.1 - 0.082 12.6 0.0 0.26 11.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) HEAT_EZ PF13513.1 KII62653.1 - 0.21 12.0 0.0 38 4.9 0.0 4.6 5 0 0 5 5 5 0 HEAT-like repeat DDE_1 PF03184.14 KII62654.1 - 5.8e-30 104.0 0.1 1e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII62654.1 - 5.6e-05 22.8 0.0 0.0001 22.0 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CtaG_Cox11 PF04442.9 KII62655.1 - 7.6e-43 145.9 0.2 1.6e-42 144.8 0.0 1.6 2 0 0 2 2 2 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DUF914 PF06027.7 KII62655.1 - 0.088 11.6 0.1 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF914) DDE_Tnp_IS1595 PF12762.2 KII62656.1 - 2.6e-15 56.5 0.0 1.1e-14 54.5 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain RnfC_N PF13375.1 KII62657.1 - 0.14 11.8 0.0 0.32 10.7 0.0 1.7 1 1 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Pectate_lyase_2 PF06917.7 KII62659.1 - 0.014 13.6 0.0 0.017 13.3 0.0 1.0 1 0 0 1 1 1 0 Periplasmic pectate lyase Aa_trans PF01490.13 KII62661.1 - 1.5e-50 171.9 38.6 1.7e-50 171.7 26.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EGF PF00008.22 KII62662.1 - 4.2e-05 23.3 18.3 0.00027 20.8 4.3 4.7 2 2 2 4 4 4 2 EGF-like domain EGF_2 PF07974.8 KII62662.1 - 7.2 6.8 45.7 1.5 9.0 4.8 4.8 3 1 1 4 4 4 0 EGF-like domain COX15-CtaA PF02628.10 KII62663.1 - 4.7e-54 183.2 6.3 8.7e-54 182.4 4.3 1.4 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein Cytochrom_B_N PF00033.14 KII62663.1 - 2.1e-06 27.2 9.0 0.014 14.7 0.4 3.8 1 1 2 3 3 3 3 Cytochrome b(N-terminal)/b6/petB ABC1 PF03109.11 KII62664.1 - 6.9e-31 106.6 0.0 1.8e-30 105.3 0.0 1.7 2 0 0 2 2 2 1 ABC1 family APH PF01636.18 KII62664.1 - 0.0048 16.6 0.0 0.13 12.0 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Asp_protease_2 PF13650.1 KII62664.1 - 0.034 14.6 0.0 0.073 13.5 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Helicase_C PF00271.26 KII62665.1 - 3.2e-12 46.1 0.1 9.5e-11 41.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Peptidase_S8 PF00082.17 KII62668.1 - 7.2e-47 159.8 0.0 9.9e-47 159.4 0.0 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 KII62668.1 - 3.9e-14 52.1 0.0 6.8e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8 PF00082.17 KII62670.1 - 9e-51 172.6 0.0 1.2e-50 172.3 0.0 1.1 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 KII62670.1 - 2.7e-12 46.2 0.0 4.8e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Rad51 PF08423.6 KII62671.1 - 3.2e-26 91.8 0.0 4.6e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 KII62671.1 - 1.8e-14 53.5 0.0 3.1e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 KII62671.1 - 2.2e-08 33.5 0.1 3.3e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 KaiC AAA_22 PF13401.1 KII62671.1 - 5.6e-06 26.5 0.0 9.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 KII62671.1 - 1.7e-05 24.0 0.1 7e-05 22.0 0.0 1.9 1 1 0 1 1 1 1 recA bacterial DNA recombination protein PAXNEB PF05625.6 KII62671.1 - 0.011 14.5 0.0 0.035 12.9 0.0 1.7 2 0 0 2 2 2 0 PAXNEB protein AAA_19 PF13245.1 KII62671.1 - 0.019 14.7 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 KII62671.1 - 0.07 13.4 0.0 0.14 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 KII62671.1 - 0.076 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase Bac_DnaA PF00308.13 KII62671.1 - 0.084 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein PduV-EutP PF10662.4 KII62671.1 - 0.1 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 KII62671.1 - 0.11 12.1 0.1 0.3 10.6 0.1 1.9 2 1 0 2 2 2 0 AAA domain Tubulin PF00091.20 KII62673.1 - 7.5e-66 222.0 0.0 9.9e-66 221.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KII62673.1 - 1.1e-46 157.9 0.0 2.3e-46 156.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 KII62673.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Tubulin domain zf-FPG_IleRS PF06827.9 KII62675.1 - 0.00041 19.9 0.7 0.0013 18.3 0.1 2.0 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS ThiF PF00899.16 KII62676.1 - 0.0077 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 ThiF family Lipin_N PF04571.9 KII62676.1 - 0.11 12.1 0.2 3.4 7.3 0.0 2.4 1 1 0 2 2 2 0 lipin, N-terminal conserved region Sigma70_r4_2 PF08281.7 KII62679.1 - 0.025 14.0 0.3 0.21 11.0 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 Gal-3-0_sulfotr PF06990.6 KII62680.1 - 1e-38 133.0 13.2 3.4e-37 128.0 9.1 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.9 KII62680.1 - 2.6e-06 27.2 11.1 4e-06 26.6 7.7 1.3 1 0 0 1 1 1 1 Sulfotransferase family Herpes_IE2_3 PF03361.9 KII62680.1 - 0.00055 19.3 0.4 0.067 12.5 0.1 2.2 2 0 0 2 2 2 2 Herpes virus intermediate/early protein 2/3 Pkinase PF00069.20 KII62681.1 - 8.7e-66 221.7 0.0 1.1e-65 221.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII62681.1 - 3.3e-35 121.3 0.0 6.5e-35 120.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KII62681.1 - 0.0099 15.6 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KII62681.1 - 0.012 14.6 0.0 0.024 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KII62681.1 - 0.013 14.5 0.0 0.022 13.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.20 KII62682.1 - 1.3e-38 132.7 0.1 1.6e-38 132.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII62682.1 - 2.6e-22 79.1 0.0 3.3e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII62682.1 - 6.8e-05 21.9 0.0 0.0001 21.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KII62682.1 - 0.00079 18.5 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KII62682.1 - 0.0022 17.3 0.5 0.0043 16.4 0.0 1.6 2 0 0 2 2 2 1 RIO1 family Seadorna_VP7 PF07387.6 KII62682.1 - 0.0031 16.4 0.0 0.0055 15.5 0.0 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.18 KII62682.1 - 0.072 12.8 0.1 0.56 9.8 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4371 PF14291.1 KII62683.1 - 0.0021 17.6 0.2 0.0045 16.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF2909 PF11137.3 KII62683.1 - 0.15 11.8 0.2 0.27 10.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) Orbi_NS3 PF01616.11 KII62685.1 - 0.11 11.4 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Orbivirus NS3 Gal-3-0_sulfotr PF06990.6 KII62686.1 - 2.8e-40 138.2 11.6 1.1e-38 132.9 8.0 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.9 KII62686.1 - 6.2e-06 26.0 8.2 6.2e-06 26.0 5.7 1.8 2 0 0 2 2 2 1 Sulfotransferase family Retrotrans_gag PF03732.12 KII62689.1 - 0.017 15.1 0.1 0.036 14.1 0.0 1.5 2 0 0 2 2 2 0 Retrotransposon gag protein DnaB PF00772.16 KII62691.1 - 0.082 12.7 0.0 0.32 10.8 0.0 1.7 2 0 0 2 2 2 0 DnaB-like helicase N terminal domain FAD_binding_1 PF00667.15 KII62692.1 - 6.2e-26 91.1 0.1 7.2e-26 90.9 0.1 1.0 1 0 0 1 1 1 1 FAD binding domain DUF1353 PF07087.6 KII62693.1 - 0.058 12.8 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) HN PF00423.14 KII62693.1 - 0.074 11.3 0.1 0.083 11.1 0.1 1.0 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase AMP-binding PF00501.23 KII62694.1 - 2.1e-71 240.5 0.0 2.7e-71 240.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme rve PF00665.21 KII62695.1 - 1.8e-22 79.6 0.0 3e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII62695.1 - 0.00028 20.2 0.5 0.00071 18.9 0.4 1.7 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII62695.1 - 0.00048 19.5 0.0 0.0018 17.7 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain HTH_23 PF13384.1 KII62696.1 - 0.03 13.9 0.0 0.16 11.6 0.1 2.1 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.1 KII62696.1 - 0.078 12.7 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_3 PF13358.1 KII62697.1 - 3.5e-27 94.9 0.0 4.9e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII62697.1 - 6.6e-05 23.0 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain HTH_32 PF13565.1 KII62697.1 - 0.00066 20.4 0.0 0.0013 19.4 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII62697.1 - 0.0014 18.6 0.2 0.0032 17.4 0.1 1.7 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.1 KII62697.1 - 0.0036 17.4 0.5 0.006 16.7 0.0 1.5 2 0 0 2 2 2 1 Winged helix-turn helix Tn7_Tnp_TnsA_C PF08721.6 KII62697.1 - 0.017 15.1 0.2 2.3 8.3 0.0 2.4 2 0 0 2 2 2 0 TnsA endonuclease C terminal HTH_23 PF13384.1 KII62697.1 - 0.11 12.1 2.5 0.95 9.1 0.0 3.2 3 1 1 4 4 4 0 Homeodomain-like domain DUF3423 PF11903.3 KII62697.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3423) DDE_1 PF03184.14 KII62697.1 - 0.12 11.4 0.0 0.32 10.0 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease DDE_3 PF13358.1 KII62698.1 - 2e-12 47.0 0.0 3.1e-12 46.4 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease Glutaredoxin PF00462.19 KII62701.1 - 5.7e-16 58.2 0.0 3.7e-15 55.6 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin Glycophorin_A PF01102.13 KII62702.1 - 0.02 14.6 1.1 0.039 13.7 0.8 1.4 1 0 0 1 1 1 0 Glycophorin A DUF2500 PF10694.4 KII62702.1 - 0.17 11.9 1.9 1 9.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) Serpin PF00079.15 KII62703.1 - 6.6e-38 130.8 10.5 1.5e-37 129.6 7.3 1.5 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3215 PF11503.3 KII62703.1 - 0.049 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3215) FAM24 PF15193.1 KII62705.1 - 0.31 11.2 2.7 0.53 10.4 1.9 1.5 1 1 0 1 1 1 0 FAM24 family OATP PF03137.15 KII62706.1 - 1.6e-32 112.3 10.1 1.6e-32 112.3 6.3 1.5 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII62706.1 - 0.00043 19.1 9.9 0.0063 15.2 3.1 2.3 3 0 0 3 3 3 2 Major Facilitator Superfamily Kazal_1 PF00050.16 KII62706.1 - 0.051 13.5 3.9 0.16 12.0 2.7 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain IU_nuc_hydro PF01156.14 KII62708.1 - 1.5e-26 93.3 0.0 1.8e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase HTH_5 PF01022.15 KII62709.1 - 0.0035 16.9 0.0 0.0058 16.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_28 PF13518.1 KII62709.1 - 0.082 12.9 0.1 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Frag1 PF10277.4 KII62710.1 - 0.25 10.8 4.4 0.3 10.5 3.1 1.1 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family CD34_antigen PF06365.7 KII62711.1 - 0.0058 16.3 0.2 0.0095 15.6 0.2 1.4 1 0 0 1 1 1 1 CD34/Podocalyxin family Nic96 PF04097.9 KII62711.1 - 0.087 10.9 0.2 0.12 10.4 0.1 1.1 1 0 0 1 1 1 0 Nup93/Nic96 UPF0560 PF10577.4 KII62711.1 - 0.18 10.0 0.2 0.22 9.7 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 stn_TNFRSF12A PF12191.3 KII62711.1 - 0.26 11.3 2.7 0.39 10.7 1.8 1.3 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain rve PF00665.21 KII62712.1 - 3.4e-23 82.0 0.0 5e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62712.1 - 4.5e-05 22.8 0.0 8.9e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain ArsC PF03960.10 KII62712.1 - 0.05 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 ArsC family Rtt106 PF08512.7 KII62713.1 - 0.038 13.9 0.9 0.047 13.6 0.6 1.2 1 0 0 1 1 1 0 Histone chaperone Rttp106-like FLYWCH PF04500.11 KII62715.1 - 1.1e-11 44.4 1.4 1.5e-11 43.9 0.9 1.2 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 KII62716.1 - 2.1e-05 24.5 0.0 4.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.12 KII62716.1 - 0.016 14.7 0.0 0.039 13.5 0.0 1.6 1 1 0 1 1 1 0 Transposase YfbU PF03887.9 KII62717.1 - 0.021 14.3 0.0 0.027 14.0 0.0 1.1 1 0 0 1 1 1 0 YfbU domain TPR_11 PF13414.1 KII62718.1 - 9.8e-64 210.9 16.6 8.6e-21 73.3 1.0 5.3 4 1 2 6 6 6 6 TPR repeat TPR_1 PF00515.23 KII62718.1 - 2.1e-54 178.9 22.2 1.7e-08 33.6 0.1 8.4 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.12 KII62718.1 - 3.3e-45 148.3 14.9 1.8e-06 27.4 0.1 8.4 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_12 PF13424.1 KII62718.1 - 1.6e-27 95.2 11.8 5e-10 39.1 0.0 6.6 3 3 2 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.1 KII62718.1 - 1.2e-23 81.0 19.3 0.001 18.6 0.3 8.7 7 1 1 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.1 KII62718.1 - 1.9e-21 74.6 0.1 0.001 19.4 0.1 7.3 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 KII62718.1 - 1.3e-20 73.5 0.1 0.00044 20.8 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.1 KII62718.1 - 1e-18 65.5 5.6 0.00058 19.4 0.0 7.5 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.1 KII62718.1 - 3.6e-15 54.8 9.1 0.00038 20.4 0.4 7.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 KII62718.1 - 4.4e-14 52.5 4.7 0.0033 17.7 0.0 5.4 3 2 3 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 KII62718.1 - 2.5e-11 43.2 10.4 0.7 10.4 0.1 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat Apc3 PF12895.2 KII62718.1 - 3e-09 36.9 13.6 0.00071 19.6 1.5 4.1 3 1 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 KII62718.1 - 1.3e-08 34.5 0.2 0.014 15.1 0.0 5.0 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.1 KII62718.1 - 2.1e-07 30.6 2.4 1.2 9.1 0.1 6.8 7 1 1 8 8 8 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII62718.1 - 0.00044 20.0 8.5 0.08 12.8 0.2 5.5 5 1 1 6 6 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.4 KII62718.1 - 0.0024 17.8 11.4 0.56 10.1 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat MAS20 PF02064.10 KII62718.1 - 0.0033 17.3 0.4 3.2 7.6 0.1 3.0 3 0 0 3 3 3 1 MAS20 protein import receptor TPR_15 PF13429.1 KII62718.1 - 0.0041 16.2 2.5 13 4.7 0.3 4.3 2 2 3 5 5 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 KII62718.1 - 0.008 15.3 1.4 12 5.2 0.0 4.6 5 0 0 5 5 5 0 SHNi-TPR BTAD PF03704.12 KII62718.1 - 0.028 14.7 0.2 0.53 10.5 0.0 2.8 2 2 0 2 2 2 0 Bacterial transcriptional activator domain TPR_20 PF14561.1 KII62718.1 - 0.03 14.4 0.1 1.4 9.0 0.0 3.2 3 1 0 3 3 2 0 Tetratricopeptide repeat DUF3856 PF12968.2 KII62718.1 - 0.036 13.8 6.7 7.3 6.4 0.7 5.3 2 2 0 3 3 3 0 Domain of Unknown Function (DUF3856) Sel1 PF08238.7 KII62718.1 - 0.057 14.0 2.6 17 6.2 0.2 4.0 3 0 0 3 3 3 0 Sel1 repeat Hep_59 PF07052.6 KII62718.1 - 0.18 12.1 3.2 0.35 11.2 0.2 2.8 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 DUF627 PF04781.7 KII62718.1 - 0.38 10.3 5.3 1.1 8.8 0.0 3.1 4 0 0 4 4 3 0 Protein of unknown function (DUF627) TarH PF02203.10 KII62718.1 - 0.65 9.8 3.1 7.6 6.3 0.1 2.4 2 0 0 2 2 2 0 Tar ligand binding domain homologue MIT PF04212.13 KII62718.1 - 0.95 9.3 21.5 1.1 9.2 0.3 5.8 5 2 0 5 5 5 0 MIT (microtubule interacting and transport) domain Sec5 PF15469.1 KII62718.1 - 5.4 6.6 7.3 21 4.7 0.2 3.4 3 1 1 4 4 4 0 Exocyst complex component Sec5 EGF PF00008.22 KII62719.1 - 0.00087 19.2 5.1 0.00087 19.2 3.5 2.4 2 1 0 2 2 2 1 EGF-like domain EGF_2 PF07974.8 KII62719.1 - 0.026 14.6 9.2 0.026 14.6 6.4 2.4 2 1 0 2 2 2 0 EGF-like domain hEGF PF12661.2 KII62719.1 - 0.054 13.5 3.1 0.054 13.5 2.2 2.1 2 0 0 2 2 2 0 Human growth factor-like EGF Dexa_ind PF15198.1 KII62719.1 - 0.1 12.4 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Dexamethasone-induced DUF3967 PF13152.1 KII62722.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3967) AMP-binding PF00501.23 KII62724.1 - 4.7e-72 242.6 0.0 6.5e-72 242.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF759 PF05537.6 KII62724.1 - 0.12 11.1 0.1 0.18 10.5 0.1 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF759) Lpp-LpqN PF10738.4 KII62725.1 - 0.061 12.5 0.0 0.068 12.4 0.0 1.1 1 0 0 1 1 1 0 Probable lipoprotein LpqN AMP-binding PF00501.23 KII62726.1 - 1.6e-79 267.2 0.0 2.3e-79 266.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DDE_3 PF13358.1 KII62727.1 - 0.0012 18.5 0.0 0.004 16.8 0.0 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease MtN3_slv PF03083.11 KII62728.1 - 0.017 15.0 0.5 0.033 14.0 0.3 1.5 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange AMP-binding PF00501.23 KII62729.1 - 5.2e-33 114.0 0.0 6.7e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KII62729.1 - 0.0046 17.8 0.0 0.0068 17.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.23 KII62730.1 - 1.2e-27 96.3 0.0 4e-26 91.3 0.0 2.0 1 1 1 2 2 2 2 AMP-binding enzyme Trm112p PF03966.11 KII62731.1 - 3.4e-10 40.1 0.0 4.3e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein MFS_1 PF07690.11 KII62732.1 - 4.3e-22 78.2 32.0 9.6e-18 64.0 11.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RabGAP-TBC PF00566.13 KII62736.1 - 1.8e-05 24.3 1.5 5.2e-05 22.8 0.4 2.0 1 1 1 2 2 2 1 Rab-GTPase-TBC domain MCM PF00493.18 KII62739.1 - 2.2e-140 467.1 0.3 2.9e-140 466.7 0.2 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 KII62739.1 - 1.6e-21 77.0 0.9 4.5e-21 75.5 0.6 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 KII62739.1 - 1.2e-08 34.3 0.0 7.2e-07 28.5 0.0 2.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 KII62739.1 - 0.00012 21.6 0.0 0.0009 18.8 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KII62739.1 - 0.00016 21.3 0.0 0.00043 20.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.24 KII62739.1 - 0.0048 17.1 0.0 0.016 15.3 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KII62739.1 - 0.006 16.0 0.1 0.097 12.1 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain IL1_propep PF02394.11 KII62739.1 - 9 6.7 8.7 21 5.5 0.0 4.3 5 0 0 5 5 5 0 Interleukin-1 propeptide Ras PF00071.17 KII62741.1 - 4.1e-45 153.0 2.0 1.5e-26 92.7 0.0 2.0 1 1 1 2 2 2 2 Ras family Miro PF08477.8 KII62741.1 - 8.5e-11 42.3 0.4 4.8e-09 36.7 0.0 2.4 1 1 1 2 2 2 1 Miro-like protein GTP_EFTU PF00009.22 KII62741.1 - 1.3e-06 27.9 0.5 0.022 14.2 0.3 3.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.12 KII62741.1 - 0.00048 19.7 0.2 0.21 11.1 0.0 2.1 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 KII62741.1 - 0.00055 19.8 0.0 0.00065 19.6 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 KII62741.1 - 0.00084 18.6 0.4 0.12 11.6 0.0 2.1 1 1 1 2 2 2 2 ADP-ribosylation factor family AAA_22 PF13401.1 KII62741.1 - 0.0043 17.1 0.1 0.015 15.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AIG1 PF04548.11 KII62741.1 - 0.077 12.0 0.3 0.13 11.3 0.0 1.6 2 0 0 2 2 2 0 AIG1 family RNA_helicase PF00910.17 KII62741.1 - 0.089 12.9 0.0 0.37 10.9 0.0 2.0 1 1 1 2 2 2 0 RNA helicase AAA_16 PF13191.1 KII62741.1 - 0.11 12.5 0.1 0.24 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain DUF3878 PF12994.2 KII62742.1 - 0.0033 16.6 0.0 0.0054 15.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3878) Glycos_transf_4 PF00953.16 KII62743.1 - 2.1e-33 115.3 14.8 2.1e-33 115.3 10.2 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 4 zf-UBR PF02207.15 KII62744.1 - 2.9e-15 55.7 17.3 2.9e-15 55.7 12.0 4.4 4 1 1 5 5 5 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 KII62744.1 - 1.8e-11 43.5 0.0 4.6e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS YrvL PF14184.1 KII62747.1 - 0.73 9.6 5.2 1.1 9.0 3.6 1.2 1 0 0 1 1 1 0 Regulatory protein YrvL POPLD PF08170.7 KII62748.1 - 7.9e-06 25.6 0.0 1.5e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.6 KII62748.1 - 0.0093 15.9 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain POP1 PF06978.6 KII62749.1 - 1.5e-19 70.4 11.6 2.9e-13 49.9 6.7 2.1 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 DUF3843 PF12954.2 KII62749.1 - 0.011 14.8 0.1 0.014 14.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3843) IFR3_antag PF14754.1 KII62752.1 - 0.039 12.9 0.0 0.053 12.5 0.0 1.1 1 0 0 1 1 1 0 Papain-like auto-proteinase His_binding PF02098.11 KII62752.1 - 0.073 12.8 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Tick histamine binding protein Ldl_recept_a PF00057.13 KII62754.1 - 8.7e-28 95.9 81.8 4.3e-07 29.7 6.6 5.3 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A WD40 PF00400.27 KII62755.1 - 3e-16 58.6 1.6 1.5e-06 27.8 0.0 5.2 6 0 0 6 6 6 3 WD domain, G-beta repeat AA_permease_2 PF13520.1 KII62756.1 - 1e-19 70.3 26.6 1.2e-19 70.2 18.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII62756.1 - 2.8e-10 39.1 23.9 3.3e-10 38.9 16.6 1.0 1 0 0 1 1 1 1 Amino acid permease Oxidored_q1_N PF00662.15 KII62756.1 - 0.013 15.0 3.7 0.013 15.0 2.6 2.0 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus CAF1 PF04857.15 KII62757.1 - 1.7e-51 175.0 3.7 4e-51 173.8 2.6 1.5 1 1 0 1 1 1 1 CAF1 family ribonuclease YabP PF07873.6 KII62758.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 YabP family RmlD_sub_bind PF04321.12 KII62759.1 - 0.00091 18.1 0.0 0.0016 17.3 0.0 1.4 2 0 0 2 2 2 1 RmlD substrate binding domain DNA_pol_A_exo1 PF01612.15 KII62761.1 - 1e-41 142.3 0.1 1.7e-41 141.5 0.1 1.4 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.18 KII62761.1 - 3.6e-05 23.3 0.0 3.6e-05 23.3 0.0 2.1 3 0 0 3 3 3 1 HRDC domain Presenilin PF01080.12 KII62762.1 - 1.7 7.3 3.8 2 7.1 2.7 1.3 1 0 0 1 1 1 0 Presenilin Serpin PF00079.15 KII62765.1 - 3.7e-20 72.4 0.2 3.8e-10 39.4 0.0 2.0 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) DAD PF02109.11 KII62767.1 - 4.2e-35 120.2 2.5 5e-35 119.9 1.7 1.0 1 0 0 1 1 1 1 DAD family DUF2463 PF09591.5 KII62767.1 - 0.045 13.3 3.0 0.054 13.0 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) DUF3353 PF11833.3 KII62767.1 - 0.14 11.6 0.1 0.26 10.7 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3353) DUF3361 PF11841.3 KII62768.1 - 0.00027 20.6 0.7 0.00069 19.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) UCH PF00443.24 KII62768.1 - 0.2 10.7 1.7 0.3 10.1 0.9 1.6 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PDZ PF00595.19 KII62771.1 - 3.7e-09 36.6 0.6 1.8e-08 34.4 0.1 2.1 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII62771.1 - 0.0093 15.8 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.12 KII62772.1 - 9.6e-21 74.0 0.4 2.2e-19 69.5 0.3 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.2 KII62772.1 - 4.2e-20 71.8 0.0 4.4e-13 49.3 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KII62772.1 - 7.1e-14 51.5 0.1 9.2e-05 22.5 0.0 3.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Pkinase PF00069.20 KII62772.1 - 8e-14 51.4 1.1 2.5e-13 49.7 0.8 1.8 1 1 0 1 1 1 1 Protein kinase domain Ank PF00023.25 KII62772.1 - 1.2e-13 50.1 0.0 1.2e-06 27.9 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KII62772.1 - 2.2e-13 50.3 0.1 2.1e-06 28.0 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII62772.1 - 2.6e-09 36.4 0.2 0.045 13.9 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Coq4 PF05019.8 KII62774.1 - 5.3e-25 87.6 0.0 5.9e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 PDZ PF00595.19 KII62775.1 - 8.8e-11 41.8 0.2 1e-10 41.6 0.1 1.1 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Peptidase_A25 PF03418.9 KII62775.1 - 0.016 13.9 0.3 0.019 13.7 0.2 1.0 1 0 0 1 1 1 0 Germination protease Herpes_glycop PF01528.11 KII62776.1 - 0.012 14.3 0.7 0.012 14.2 0.5 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Rtf2 PF04641.7 KII62777.1 - 4e-69 232.7 9.4 4.8e-69 232.4 6.5 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger CO_dh PF02552.11 KII62777.1 - 0.017 14.6 1.2 0.021 14.3 0.1 1.7 2 0 0 2 2 2 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit zf-RING_UBOX PF13445.1 KII62777.1 - 0.019 14.6 0.5 0.081 12.6 0.0 2.4 2 1 1 3 3 3 0 RING-type zinc-finger DDE_3 PF13358.1 KII62780.1 - 8.9e-11 41.7 0.0 1.4e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Cullin PF00888.17 KII62782.1 - 6.4e-16 58.0 16.9 8.1e-16 57.6 11.7 1.1 1 0 0 1 1 1 1 Cullin family Pox_G7 PF05503.7 KII62782.1 - 0.0051 15.4 0.3 0.0098 14.5 0.2 1.4 1 0 0 1 1 1 1 Poxvirus G7-like DUF2577 PF10844.3 KII62782.1 - 0.021 14.8 0.6 2.5 8.1 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2577) CDP-OH_P_transf PF01066.16 KII62783.1 - 1.4e-16 60.6 4.4 2e-16 60.0 3.1 1.3 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase TFIIA_gamma_N PF02268.11 KII62784.1 - 7.3e-13 47.8 0.0 1.1e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.9 KII62784.1 - 1.3e-09 37.6 0.6 2e-09 37.0 0.4 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit KH_1 PF00013.24 KII62785.1 - 5.5e-17 61.1 26.0 2.6e-07 30.1 0.0 9.8 13 0 0 13 13 13 6 KH domain KH_3 PF13014.1 KII62785.1 - 4.2e-10 39.0 7.3 7e-05 22.3 0.0 6.6 6 0 0 6 6 6 2 KH domain DUF2067 PF09840.4 KII62785.1 - 0.0067 15.9 0.4 0.0067 15.9 0.3 2.7 3 0 0 3 3 3 1 Uncharacterized protein conserved in archaea (DUF2067) eIF-5_eIF-2B PF01873.12 KII62786.1 - 1.5e-36 124.8 0.2 5.8e-36 122.9 0.1 1.9 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.13 KII62786.1 - 8.1e-21 73.7 0.8 2.1e-20 72.4 0.5 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Nop10p PF04135.7 KII62786.1 - 0.08 12.6 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family MRP-S28 PF10213.4 KII62787.1 - 8.4e-12 45.2 0.1 1.4e-11 44.5 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein RF-1 PF00472.15 KII62787.1 - 0.0039 16.9 0.0 0.0064 16.2 0.0 1.4 1 0 0 1 1 1 1 RF-1 domain Ribosomal_S25 PF03297.10 KII62787.1 - 0.075 13.0 0.5 0.26 11.3 0.1 2.1 2 0 0 2 2 2 0 S25 ribosomal protein P5CR_dimer PF14748.1 KII62788.1 - 6e-32 109.8 0.0 8.9e-32 109.2 0.0 1.3 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 KII62788.1 - 9.9e-13 48.3 0.6 2.4e-12 47.1 0.1 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 KII62788.1 - 0.0013 18.4 0.1 0.0028 17.3 0.1 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Semialdhyde_dh PF01118.19 KII62788.1 - 0.13 12.5 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain PAP2_C PF14360.1 KII62789.1 - 1.8e-20 72.9 15.0 1.8e-20 72.9 10.4 3.3 4 0 0 4 4 4 1 PAP2 superfamily C-terminal PAP2_3 PF14378.1 KII62789.1 - 5.4e-06 26.0 14.8 6.2e-06 25.8 9.2 1.8 2 1 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.16 KII62789.1 - 7.4e-05 22.4 15.1 0.00031 20.4 10.5 2.0 1 1 0 1 1 1 1 PAP2 superfamily Med25_NR-box PF11244.3 KII62790.1 - 0.024 15.0 2.7 0.052 13.9 1.9 1.6 1 1 0 1 1 1 0 Mediator complex subunit 25 C-terminal NR box-containing HSP70 PF00012.15 KII62791.1 - 3.3e-50 170.6 17.1 3.3e-50 170.6 11.9 3.2 1 1 1 2 2 2 1 Hsp70 protein TPP1 PF10341.4 KII62791.1 - 0.096 12.6 4.2 1.2 9.1 0.1 3.2 3 0 0 3 3 3 0 Shelterin complex subunit, TPP1/ACD Ank_4 PF13637.1 KII62792.1 - 2.8e-14 53.1 0.0 9.7e-07 29.1 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KII62792.1 - 1.6e-13 49.7 0.0 5.1e-07 29.1 0.0 3.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.2 KII62792.1 - 1.9e-13 50.5 0.0 7.8e-11 42.1 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KII62792.1 - 3.2e-12 45.4 0.0 3.9e-06 26.5 0.0 3.6 3 1 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KII62792.1 - 4.4e-07 29.9 0.0 3.1e-06 27.2 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 KII62792.1 - 0.057 12.9 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Shigella flexneri OspC protein HSP70 PF00012.15 KII62793.1 - 1e-233 776.7 7.4 1.3e-233 776.4 5.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KII62793.1 - 9.7e-12 44.1 0.1 5.4e-10 38.3 0.0 3.0 2 1 0 2 2 2 1 MreB/Mbl protein Mnd1 PF03962.10 KII62793.1 - 0.21 11.2 10.7 4.9 6.7 0.1 2.2 2 0 0 2 2 2 0 Mnd1 family FtsA PF14450.1 KII62793.1 - 5.1 6.9 10.8 1.3 8.8 0.3 3.7 3 1 0 3 3 3 0 Cell division protein FtsA Adipogenin PF15202.1 KII62794.1 - 0.012 15.4 0.3 0.022 14.6 0.2 1.4 1 0 0 1 1 1 0 Adipogenin ATP-synt_8 PF00895.15 KII62794.1 - 0.048 13.8 2.5 0.048 13.8 1.7 2.1 2 0 0 2 2 2 0 ATP synthase protein 8 Baculo_11_kDa PF06143.6 KII62794.1 - 0.092 12.1 0.4 0.17 11.2 0.3 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family MRAP PF15183.1 KII62794.1 - 0.11 12.1 0.4 0.21 11.2 0.3 1.4 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family DUF2077 PF09850.4 KII62794.1 - 0.14 11.5 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2077) Pox_A9 PF04835.7 KII62794.1 - 9 6.2 9.1 0.64 9.9 2.4 2.0 2 1 1 3 3 3 0 A9 protein conserved region DUF3963 PF13124.1 KII62795.1 - 0.42 10.4 0.3 0.42 10.4 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3963) zf-C2H2 PF00096.21 KII62796.1 - 2.2e-13 49.6 31.4 0.00058 20.0 5.3 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII62796.1 - 3.3e-11 42.6 30.0 0.004 17.3 3.7 5.2 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KII62796.1 - 4.8e-09 36.0 32.2 3.2e-06 27.1 1.1 5.7 5 1 0 5 5 5 3 Zinc-finger double domain zf-H2C2_5 PF13909.1 KII62796.1 - 0.00064 19.8 25.5 0.0067 16.5 1.3 4.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-met PF12874.2 KII62796.1 - 0.016 15.4 1.1 0.016 15.4 0.7 5.0 5 1 0 5 5 5 0 Zinc-finger of C2H2 type zf-LYAR PF08790.6 KII62796.1 - 0.034 13.8 1.5 0.034 13.8 1.0 3.8 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger Zn-ribbon_8 PF09723.5 KII62796.1 - 0.33 10.9 0.1 0.33 10.9 0.1 4.6 4 0 0 4 4 4 0 Zinc ribbon domain XPA_N PF01286.13 KII62796.1 - 0.56 9.9 11.5 1.5 8.5 1.2 3.0 3 0 0 3 3 3 0 XPA protein N-terminal zf-C2H2_jaz PF12171.3 KII62796.1 - 3.1 8.0 31.6 0.21 11.7 0.5 5.1 4 2 1 5 5 5 0 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.9 KII62796.1 - 6 6.6 8.5 27 4.5 0.0 3.0 2 1 0 2 2 2 0 Adenylate kinase, active site lid LIM PF00412.17 KII62796.1 - 7.5 6.7 20.1 0.83 9.7 3.9 3.8 3 1 1 4 4 4 0 LIM domain UbiA PF01040.13 KII62798.1 - 1.3e-16 60.6 0.5 1.4e-16 60.5 0.4 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family Sterol-sensing PF12349.3 KII62798.1 - 0.089 12.2 0.3 0.13 11.6 0.2 1.2 1 0 0 1 1 1 0 Sterol-sensing domain of SREBP cleavage-activation JmjC PF02373.17 KII62799.1 - 0.01 16.0 0.2 0.021 15.0 0.1 1.6 1 1 0 1 1 1 0 JmjC domain, hydroxylase DDE_3 PF13358.1 KII62800.1 - 2.2e-17 63.1 0.1 2.9e-17 62.7 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease LolA PF03548.10 KII62800.1 - 0.013 15.1 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA rve PF00665.21 KII62800.1 - 0.034 14.2 0.0 0.047 13.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_38 PF13936.1 KII62802.1 - 3.6e-07 29.6 0.0 5.8e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII62802.1 - 4.7e-07 29.9 0.0 5.5e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII62802.1 - 1.3e-06 27.8 0.0 2.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII62802.1 - 3e-06 27.1 0.1 5.7e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.13 KII62802.1 - 0.00019 21.1 0.1 0.00022 20.9 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.1 KII62802.1 - 0.0011 18.7 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII62802.1 - 0.0011 18.5 0.1 0.0013 18.3 0.1 1.1 1 0 0 1 1 1 1 Transposase HTH_11 PF08279.7 KII62802.1 - 0.0044 16.6 0.3 0.0075 15.9 0.2 1.4 1 0 0 1 1 1 1 HTH domain HTH_40 PF14493.1 KII62802.1 - 0.011 15.8 0.1 0.018 15.2 0.1 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.10 KII62802.1 - 0.014 15.1 1.3 0.062 13.1 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase Sigma70_r4 PF04545.11 KII62802.1 - 0.029 13.6 0.0 0.17 11.2 0.0 2.1 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_Tnp_1 PF01527.15 KII62802.1 - 0.031 14.2 0.0 0.04 13.8 0.0 1.4 1 1 0 1 1 1 0 Transposase Helicase_RecD PF05127.9 KII62802.1 - 0.042 13.4 0.0 0.047 13.3 0.0 1.1 1 0 0 1 1 1 0 Helicase MarR PF01047.17 KII62802.1 - 0.053 13.2 0.2 0.3 10.8 0.1 2.1 1 1 0 1 1 1 0 MarR family TrmB PF01978.14 KII62802.1 - 0.053 13.2 0.1 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_32 PF13565.1 KII62802.1 - 0.11 13.3 0.0 0.21 12.4 0.0 1.4 2 0 0 2 2 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.7 KII62802.1 - 0.12 11.7 0.1 0.5 9.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 rve PF00665.21 KII62806.1 - 7.9e-26 90.5 0.1 1e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62806.1 - 0.00012 21.4 0.1 0.00025 20.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII62806.1 - 0.072 13.0 0.1 0.15 12.0 0.0 1.5 2 0 0 2 2 2 0 DDE domain Imm48 PF15587.1 KII62808.1 - 0.067 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 48 HTH_Tnp_IS630 PF01710.11 KII62809.1 - 7.1e-05 22.4 0.1 8.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Transposase DUF4304 PF14137.1 KII62811.1 - 0.032 14.3 0.5 0.064 13.3 0.4 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4304) DUF4293 PF14126.1 KII62811.1 - 0.098 12.5 0.2 1.2 9.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Vasohibin PF14822.1 KII62812.1 - 0.021 13.9 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Vasohibin Chordopox_A13L PF05961.6 KII62816.1 - 0.073 13.0 0.7 0.17 11.7 0.5 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein EGF_2 PF07974.8 KII62818.1 - 0.0078 16.3 8.7 0.0078 16.3 6.1 1.9 2 0 0 2 2 2 1 EGF-like domain Apis_Csd PF11671.3 KII62818.1 - 0.019 14.7 0.6 0.041 13.6 0.3 1.7 1 1 0 1 1 1 0 Complementary sex determiner protein GTP_cyclohydro2 PF00925.15 KII62819.1 - 0.023 13.9 0.0 0.031 13.5 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase II DUF3543 PF12063.3 KII62821.1 - 0.012 14.8 0.0 0.016 14.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3543) ORC6 PF05460.8 KII62822.1 - 0.18 10.8 0.3 0.27 10.3 0.2 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DBINO PF13892.1 KII62824.1 - 8 6.4 15.8 12 5.9 10.9 1.2 1 0 0 1 1 1 0 DNA-binding domain rpo132 PF12415.3 KII62825.1 - 0.065 12.1 0.0 0.15 11.0 0.0 1.6 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase POPLD PF08170.7 KII62827.1 - 0.059 13.2 2.0 0.084 12.7 1.4 1.2 1 0 0 1 1 1 0 POPLD (NUC188) domain ERK-JNK_inhib PF15002.1 KII62827.1 - 1.1 8.6 9.9 5.8 6.2 0.0 2.0 1 1 1 2 2 2 0 ERK and JNK pathways, inhibitor MAP7 PF05672.6 KII62827.1 - 1.9 7.8 35.3 1.8 7.8 0.3 2.0 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Paf1 PF03985.8 KII62827.1 - 2.2 6.9 14.3 2.5 6.7 9.9 1.0 1 0 0 1 1 1 0 Paf1 Lin-8 PF03353.10 KII62827.1 - 3 7.0 15.5 3.9 6.6 10.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist rve PF00665.21 KII62828.1 - 2.1e-09 37.5 0.2 3.8e-09 36.6 0.2 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62828.1 - 4.9e-05 22.7 0.0 0.00013 21.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain CFTR_R PF14396.1 KII62829.1 - 0.083 12.2 2.1 0.25 10.7 0.2 2.0 1 1 0 2 2 2 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain DDE_3 PF13358.1 KII62830.1 - 3.9e-29 101.2 0.0 4.6e-29 101.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII62830.1 - 4.5e-05 22.6 0.1 0.0069 15.5 0.0 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF2250 PF10007.4 KII62831.1 - 0.034 14.0 0.0 0.069 13.0 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) MarR_2 PF12802.2 KII62831.1 - 0.056 13.1 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 MarR family PCI PF01399.22 KII62832.1 - 1.1e-09 38.5 0.2 3.3e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 PCI domain DUF2164 PF09932.4 KII62832.1 - 0.0022 17.7 1.7 0.0043 16.8 0.2 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2164) zf-C4_ClpX PF06689.8 KII62832.1 - 0.085 12.3 0.5 0.3 10.6 0.2 2.0 2 0 0 2 2 2 0 ClpX C4-type zinc finger zf-RanBP PF00641.13 KII62833.1 - 3.6e-07 29.1 12.0 8.1e-05 21.6 1.7 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Lar_restr_allev PF14354.1 KII62833.1 - 0.98 9.7 5.7 6.7 7.0 0.5 2.4 1 1 1 2 2 2 0 Restriction alleviation protein Lar zf-Apc11 PF12861.2 KII62833.1 - 3.1 7.6 7.7 0.91 9.4 0.5 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger eIF-3c_N PF05470.7 KII62834.1 - 1.1e-115 387.0 23.6 1.7e-115 386.4 16.4 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 KII62834.1 - 0.13 12.6 0.0 0.13 12.6 0.0 3.5 5 1 0 5 5 5 0 PCI domain Ldl_recept_a PF00057.13 KII62835.1 - 0.00066 19.5 38.0 0.0039 17.0 10.4 3.9 3 1 0 3 3 3 2 Low-density lipoprotein receptor domain class A ODV-E18 PF10717.4 KII62835.1 - 0.0017 17.7 0.6 0.003 16.9 0.4 1.3 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 TMEM154 PF15102.1 KII62835.1 - 0.096 12.3 0.4 0.2 11.3 0.2 1.5 1 0 0 1 1 1 0 TMEM154 protein family Cortexin PF11057.3 KII62835.1 - 0.11 12.0 1.4 0.2 11.3 1.0 1.3 1 0 0 1 1 1 0 Cortexin of kidney DUF4519 PF15012.1 KII62835.1 - 1.4 8.9 4.3 2.6 8.0 3.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) TMEM156 PF15106.1 KII62835.1 - 1.4 8.0 11.3 0.033 13.4 2.8 2.0 2 1 0 2 2 2 0 TMEM156 protein family EphA2_TM PF14575.1 KII62835.1 - 2.8 8.3 6.6 2.6 8.4 1.3 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ldl_recept_a PF00057.13 KII62836.1 - 4.8e-40 135.1 80.7 2e-12 46.8 10.1 4.7 4 1 1 5 5 5 4 Low-density lipoprotein receptor domain class A DUF3974 PF13120.1 KII62837.1 - 0.034 13.9 0.0 0.041 13.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3974) COBRA1 PF06209.8 KII62837.1 - 0.097 11.2 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Cofactor of BRCA1 (COBRA1) TRM PF02005.11 KII62839.1 - 0.042 12.7 0.1 0.056 12.3 0.1 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase TAFH PF07531.9 KII62840.1 - 0.0059 16.2 0.0 0.0077 15.8 0.0 1.2 1 0 0 1 1 1 1 NHR1 homology to TAF ox_reductase_C PF08635.5 KII62843.1 - 0.017 14.5 0.2 4.1 6.8 0.0 2.1 2 0 0 2 2 2 0 Putative oxidoreductase C terminal SMC_Nse1 PF07574.8 KII62843.1 - 0.12 11.9 0.1 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex Ribosomal_L4 PF00573.17 KII62845.1 - 3.3e-27 95.1 0.0 4.3e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family tRNA-synt_1b PF00579.20 KII62846.1 - 1.2e-21 77.0 0.0 1.8e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DDE_Tnp_IS1595 PF12762.2 KII62847.1 - 0.00013 21.7 0.0 0.0024 17.6 0.0 2.1 1 1 0 1 1 1 1 ISXO2-like transposase domain RRM_1 PF00076.17 KII62849.1 - 2e-78 257.9 4.6 1.8e-20 72.3 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII62849.1 - 2.6e-54 181.0 0.5 6e-14 51.7 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII62849.1 - 2.3e-36 123.4 2.9 1.4e-09 37.6 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII62849.1 - 1.3e-09 37.8 5.1 0.024 14.4 1.2 4.3 4 0 0 4 4 4 3 RNA binding motif Nup35_RRM_2 PF14605.1 KII62849.1 - 0.00014 21.5 0.1 0.93 9.3 0.0 4.3 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.6 KII62849.1 - 0.0015 18.4 0.1 0.57 10.2 0.0 3.5 4 0 0 4 4 4 1 RNA binding domain NosL PF05573.7 KII62849.1 - 0.0024 17.5 0.1 0.036 13.7 0.0 2.6 2 0 0 2 2 2 1 NosL RRM_2 PF04059.7 KII62849.1 - 0.061 13.3 0.7 2.3 8.2 0.1 3.0 4 0 0 4 4 4 0 RNA recognition motif 2 DUF2705 PF10920.3 KII62853.1 - 0.0016 17.7 0.4 0.002 17.3 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2705) Chordopox_A13L PF05961.6 KII62853.1 - 0.014 15.3 1.1 0.11 12.3 0.7 2.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein DUF2659 PF10858.3 KII62853.1 - 0.027 13.8 1.5 0.037 13.4 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2659) DUF912 PF06024.7 KII62853.1 - 0.043 13.8 0.0 0.052 13.6 0.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) TMEM154 PF15102.1 KII62853.1 - 0.11 12.2 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family SH PF01445.12 KII62853.1 - 0.13 11.9 1.2 0.2 11.3 0.9 1.3 1 0 0 1 1 1 0 Viral small hydrophobic protein Synaptobrevin PF00957.16 KII62853.1 - 8.4 6.0 7.1 10 5.7 4.4 1.6 1 1 0 1 1 1 0 Synaptobrevin DUF912 PF06024.7 KII62854.1 - 0.014 15.3 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3753 PF12575.3 KII62854.1 - 0.022 14.5 0.5 0.045 13.5 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Bac_surface_Ag PF01103.18 KII62854.1 - 0.031 13.7 1.5 0.043 13.2 1.0 1.2 1 0 0 1 1 1 0 Surface antigen Chordopox_A13L PF05961.6 KII62854.1 - 0.2 11.5 4.5 0.22 11.4 1.1 2.4 3 0 0 3 3 3 0 Chordopoxvirus A13L protein RVP PF00077.15 KII62855.1 - 1.2e-05 25.1 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII62855.1 - 0.08 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease FKBP_C PF00254.23 KII62856.1 - 1.6e-12 47.2 0.0 3.2e-12 46.3 0.0 1.4 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 KII62857.1 - 1.8e-10 40.2 2.3 1.2e-05 24.8 1.2 2.5 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KII62857.1 - 7.3e-08 31.6 2.3 0.095 12.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII62857.1 - 1.1e-06 28.0 2.9 0.16 11.9 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII62857.1 - 3.3e-05 23.7 0.0 0.013 15.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KII62857.1 - 4.9e-05 23.5 0.1 0.0032 17.7 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 KII62857.1 - 0.00073 19.6 3.7 0.001 19.1 1.3 2.2 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 KII62857.1 - 0.0028 18.2 0.0 3.1 8.5 0.8 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII62857.1 - 0.0028 17.4 0.3 0.031 14.1 0.0 2.8 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.1 KII62857.1 - 0.13 12.0 0.0 0.13 12.0 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Saw1 PF11561.3 KII62860.1 - 0.06 12.7 0.0 0.07 12.5 0.0 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 JTB PF05439.7 KII62861.1 - 0.007 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) Albumin_I PF08027.6 KII62861.1 - 0.074 12.7 0.0 0.3 10.8 0.0 1.9 2 0 0 2 2 2 0 Albumin I Hexokinase_2 PF03727.11 KII62862.1 - 1.3e-63 214.4 0.0 1.6e-63 214.1 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII62862.1 - 1.2e-55 187.9 0.0 1.9e-55 187.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF2464 PF10240.4 KII62863.1 - 0.00011 21.5 0.0 0.00016 21.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2464) Erv26 PF04148.8 KII62864.1 - 3.3e-10 39.6 11.8 8.3e-10 38.3 8.2 1.6 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 DUF808 PF05661.7 KII62864.1 - 0.058 12.2 0.3 0.08 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF808) Per1 PF04080.8 KII62864.1 - 0.06 12.7 1.0 0.065 12.6 0.7 1.2 1 0 0 1 1 1 0 Per1-like PMT PF02366.13 KII62864.1 - 0.093 12.0 11.3 0.066 12.5 2.8 2.2 1 1 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2207 PF09972.4 KII62864.1 - 0.23 10.0 3.1 0.27 9.7 2.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Tetraspannin PF00335.15 KII62864.1 - 0.27 10.4 6.2 0.34 10.1 4.3 1.2 1 0 0 1 1 1 0 Tetraspanin family DUF2678 PF10856.3 KII62864.1 - 0.33 10.7 5.4 0.32 10.7 2.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2678) DS PF01916.12 KII62865.1 - 4.5e-123 410.1 0.0 5.1e-123 409.9 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Glyco_transf_7C PF02709.9 KII62866.1 - 1.1e-08 34.3 0.5 2.1e-08 33.4 0.2 1.6 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase DUF2217 PF10265.4 KII62868.1 - 2.9e-38 131.9 8.6 8e-38 130.4 6.0 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2217) Pkinase PF00069.20 KII62869.1 - 6.2e-39 133.7 0.4 8.2e-39 133.3 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII62869.1 - 2.7e-18 65.9 0.1 3.5e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KII62869.1 - 0.00035 20.3 0.0 0.00056 19.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KII62869.1 - 0.019 13.9 0.2 0.058 12.3 0.0 2.0 3 0 0 3 3 3 0 Kinase-like YrbL-PhoP_reg PF10707.4 KII62869.1 - 0.058 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF106 PF01956.11 KII62870.1 - 1.1e-24 86.8 1.8 1.3e-24 86.6 1.3 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF106 SNARE_assoc PF09335.6 KII62870.1 - 0.095 12.9 1.0 0.32 11.2 0.7 1.8 1 1 0 1 1 1 0 SNARE associated Golgi protein Cyclin_C PF02984.14 KII62870.1 - 0.43 10.5 2.0 0.78 9.6 0.2 1.9 2 0 0 2 2 2 0 Cyclin, C-terminal domain GAF PF01590.21 KII62872.1 - 8.4e-10 38.9 0.0 4.6e-08 33.3 0.0 2.3 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.1 KII62872.1 - 4.4e-08 33.2 0.0 0.00068 19.7 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.1 KII62872.1 - 0.00073 20.0 0.0 0.045 14.2 0.0 2.2 2 0 0 2 2 2 1 GAF domain PDEase_I PF00233.14 KII62873.1 - 2.2e-25 89.8 0.0 2.4e-25 89.6 0.0 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DDE_3 PF13358.1 KII62875.1 - 2.4e-14 53.3 0.0 4.5e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII62875.1 - 4.2e-09 36.5 0.0 7.3e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix MarR_2 PF12802.2 KII62875.1 - 1.5e-05 24.5 0.0 4.2e-05 23.1 0.0 1.7 2 0 0 2 2 1 1 MarR family HTH_23 PF13384.1 KII62875.1 - 2.4e-05 23.8 0.1 0.00046 19.7 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.1 KII62875.1 - 0.00011 21.4 0.1 0.00045 19.5 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding PAX PF00292.13 KII62875.1 - 0.0002 21.0 0.0 0.00035 20.2 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_33 PF13592.1 KII62875.1 - 0.00038 19.9 0.1 0.0009 18.7 0.0 1.6 2 0 0 2 2 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII62875.1 - 0.0004 21.1 0.5 0.00076 20.2 0.0 1.7 2 0 0 2 2 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII62875.1 - 0.00059 19.7 0.1 0.026 14.5 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_38 PF13936.1 KII62875.1 - 0.0012 18.3 0.1 0.0066 15.9 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain DUF1323 PF07037.6 KII62875.1 - 0.0015 18.6 1.6 0.014 15.5 0.4 2.5 2 1 0 2 2 2 1 Putative transcription regulator (DUF1323) CENP-B_N PF04218.8 KII62875.1 - 0.0029 16.9 0.4 0.0073 15.7 0.0 1.8 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain MarR PF01047.17 KII62875.1 - 0.0037 16.9 0.1 0.026 14.2 0.0 2.4 3 0 0 3 3 3 1 MarR family Sigma70_r4 PF04545.11 KII62875.1 - 0.0069 15.6 0.1 0.022 14.0 0.0 1.9 1 1 0 1 1 1 1 Sigma-70, region 4 Fe_dep_repress PF01325.14 KII62875.1 - 0.0077 16.1 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.14 KII62875.1 - 0.01 15.5 0.0 0.034 13.8 0.0 1.8 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.1 KII62875.1 - 0.013 15.2 0.1 0.038 13.7 0.0 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain B5 PF03484.10 KII62875.1 - 0.018 14.8 0.1 0.067 13.0 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetase B5 domain EAP30 PF04157.11 KII62875.1 - 0.061 12.4 0.0 0.4 9.7 0.0 2.0 1 1 0 1 1 1 0 EAP30/Vps36 family RepL PF05732.6 KII62875.1 - 0.077 12.1 1.2 2.7 7.1 0.1 2.3 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) UPF0122 PF04297.9 KII62875.1 - 0.091 12.7 0.6 8.3 6.4 0.0 2.4 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like DDE_Tnp_IS1595 PF12762.2 KII62876.1 - 6.4e-22 78.0 0.0 2.5e-21 76.0 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain GDA1_CD39 PF01150.12 KII62879.1 - 6e-12 44.7 0.9 1.1e-11 43.9 0.6 1.3 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Tetraspannin PF00335.15 KII62879.1 - 0.017 14.3 0.4 0.053 12.7 0.0 1.9 2 0 0 2 2 2 0 Tetraspanin family ThiF PF00899.16 KII62881.1 - 3.1e-25 88.5 0.0 6.3e-25 87.5 0.0 1.5 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 KII62881.1 - 0.00089 19.3 0.1 0.0079 16.3 0.1 2.4 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 KII62881.1 - 0.09 13.0 0.0 1.2 9.4 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding Brix PF04427.13 KII62882.1 - 2.3e-18 66.5 0.1 3.9e-18 65.8 0.1 1.4 1 0 0 1 1 1 1 Brix domain DUF4041 PF13250.1 KII62883.1 - 0.011 15.2 0.7 1.7 8.2 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4041) F_actin_cap_B PF01115.12 KII62885.1 - 2.1e-94 315.2 0.0 2.7e-94 314.8 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Peptidase_S9 PF00326.16 KII62886.1 - 0.051 12.7 0.1 0.065 12.4 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Autoind_synth PF00765.12 KII62886.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Autoinducer synthetase Homeobox PF00046.24 KII62887.1 - 1.5e-08 34.1 1.9 1.5e-08 34.1 1.3 1.8 2 0 0 2 2 2 1 Homeobox domain SopA PF13981.1 KII62887.1 - 0.031 14.3 0.3 0.087 12.8 0.1 1.8 2 0 0 2 2 2 0 SopA-like central domain MtmB PF05369.7 KII62890.1 - 0.00068 17.9 0.0 11 4.0 0.0 3.7 1 1 3 4 4 4 4 Monomethylamine methyltransferase MtmB N6_Mtase PF02384.11 KII62891.1 - 0.0009 18.4 0.0 40 3.1 0.0 4.6 1 1 4 5 5 5 1 N-6 DNA Methylase DUF1324 PF07038.6 KII62891.1 - 0.012 15.6 10.7 45 4.1 0.1 5.6 5 0 0 5 5 5 0 Protein of unknown function (DUF1324) zf-TRM13_CCCH PF11722.3 KII62891.1 - 3.6 7.0 10.3 81 2.7 0.1 4.4 5 0 0 5 5 5 0 CCCH zinc finger in TRM13 protein ydhR PF08803.6 KII62892.1 - 0.0077 16.2 0.1 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Putative mono-oxygenase ydhR PSD3 PF07626.6 KII62892.1 - 0.056 13.4 0.1 0.21 11.5 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1587) IMD PF08397.6 KII62893.1 - 0.014 14.7 0.0 0.014 14.7 0.0 1.1 1 0 0 1 1 1 0 IRSp53/MIM homology domain CRAM_rpt PF07016.6 KII62893.1 - 0.021 14.1 0.3 0.06 12.6 0.0 1.9 2 0 0 2 2 2 0 Cysteine-rich acidic integral membrane protein precursor EBV-NA3 PF05009.7 KII62893.1 - 0.031 13.5 0.3 0.037 13.2 0.2 1.1 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) LIM PF00412.17 KII62893.1 - 0.056 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 LIM domain SNAP PF14938.1 KII62894.1 - 2e-07 30.4 7.1 1.6e-06 27.4 4.9 2.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.4 KII62894.1 - 0.0024 17.2 1.0 0.53 9.6 0.1 2.7 1 1 1 2 2 2 2 26S proteasome subunit RPN7 TPR_12 PF13424.1 KII62894.1 - 0.011 15.6 3.3 2.2 8.2 0.2 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat Gemini_AL1_M PF08283.6 KII62894.1 - 0.025 14.3 0.9 12 5.7 0.1 3.2 3 0 0 3 3 3 0 Geminivirus rep protein central domain Apc3 PF12895.2 KII62894.1 - 0.037 14.1 1.5 0.089 12.9 0.1 2.4 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Ribonuclease_T2 PF00445.13 KII62894.1 - 0.099 12.2 2.0 7.5 6.1 0.0 2.3 2 1 0 2 2 2 0 Ribonuclease T2 family TPR_2 PF07719.12 KII62894.1 - 0.18 11.7 7.4 61 3.8 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII62894.1 - 6 6.8 9.1 4.3 7.3 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat BNR PF02012.15 KII62897.1 - 0.0068 16.0 1.3 0.22 11.4 0.5 2.5 2 0 0 2 2 2 1 BNR/Asp-box repeat DUF4041 PF13250.1 KII62898.1 - 0.081 12.4 3.3 0.09 12.3 0.1 2.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4041) AAA_assoc PF14363.1 KII62898.1 - 0.1 12.6 0.1 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 Domain associated at C-terminal with AAA PuR_N PF09182.5 KII62902.1 - 2.4e-10 39.8 4.4 4.7 6.8 0.1 7.0 1 1 9 10 10 10 10 Bacterial purine repressor, N-terminal EF-hand_10 PF14788.1 KII62902.1 - 3.2e-07 29.9 15.0 11 5.7 0.1 8.1 1 1 10 11 11 11 11 EF hand Transposase_21 PF02992.9 KII62904.1 - 0.031 13.3 0.6 0.035 13.1 0.4 1.2 1 0 0 1 1 1 0 Transposase family tnp2 SNAP PF14938.1 KII62905.1 - 5.2e-12 45.5 0.9 7.1e-12 45.0 0.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII62905.1 - 0.018 14.9 2.5 4.5 7.4 0.2 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII62905.1 - 0.07 12.7 3.4 2 8.1 0.3 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat A_deaminase PF00962.17 KII62909.1 - 0.024 13.5 0.1 0.034 13.0 0.1 1.2 1 0 0 1 1 1 0 Adenosine/AMP deaminase HTH_Tnp_Tc3_1 PF11427.3 KII62910.1 - 0.15 11.6 0.3 15 5.3 0.0 2.6 3 0 0 3 3 3 0 Tc3 transposase AAA_21 PF13304.1 KII62911.1 - 1.2e-21 77.9 2.8 1.2e-10 41.8 0.5 2.4 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KII62911.1 - 2.8e-17 63.7 4.7 5.4e-17 62.7 3.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.1 KII62911.1 - 4.5e-15 55.6 12.7 9.7e-09 34.7 6.5 2.5 2 1 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 KII62911.1 - 2.7e-14 52.9 0.4 1.1e-13 50.9 0.3 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_tran PF00005.22 KII62911.1 - 1.7e-07 31.6 0.0 5.3e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 ABC transporter DUF2813 PF11398.3 KII62911.1 - 2.6e-06 26.7 0.2 4.5e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2813) AAA_29 PF13555.1 KII62911.1 - 4.2e-06 26.1 0.1 8.2e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.1 KII62911.1 - 9.1e-05 21.1 1.8 0.00015 20.4 1.2 1.3 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KII62911.1 - 0.0027 17.1 0.1 0.087 12.2 0.1 2.3 1 1 0 1 1 1 1 AAA-like domain AAA_16 PF13191.1 KII62911.1 - 0.0094 15.9 0.0 0.04 13.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 KII62911.1 - 0.016 15.4 0.0 0.14 12.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 KII62911.1 - 0.035 13.2 0.0 0.083 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_ATPase PF09818.4 KII62911.1 - 0.07 11.6 0.1 0.16 10.5 0.0 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class NACHT PF05729.7 KII62911.1 - 0.077 12.6 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.1 KII62911.1 - 0.1 12.7 0.0 0.75 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain PAF-AH_p_II PF03403.8 KII62914.1 - 0.043 12.0 0.4 0.047 11.9 0.3 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Fe_dep_repress PF01325.14 KII62914.1 - 0.14 12.1 0.4 0.21 11.5 0.3 1.4 1 1 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain DEAD PF00270.24 KII62915.1 - 8.2e-07 28.6 0.0 1.4e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 KII62915.1 - 0.0009 18.2 0.0 0.0011 17.9 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.1 KII62915.1 - 0.0012 18.5 0.1 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain Arch_ATPase PF01637.13 KII62915.1 - 0.0019 17.9 0.5 0.016 14.8 0.0 2.2 2 0 0 2 2 2 1 Archaeal ATPase KaiC PF06745.8 KII62915.1 - 0.007 15.5 0.0 0.014 14.5 0.0 1.5 1 0 0 1 1 1 1 KaiC ResIII PF04851.10 KII62915.1 - 0.0076 16.1 2.4 0.29 10.9 0.8 2.8 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Zeta_toxin PF06414.7 KII62915.1 - 0.012 14.7 0.0 0.023 13.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.11 KII62915.1 - 0.02 14.1 0.2 0.086 12.0 0.0 2.1 3 0 0 3 3 3 0 PhoH-like protein AAA_14 PF13173.1 KII62915.1 - 0.024 14.5 0.0 0.36 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 KII62915.1 - 0.031 13.7 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.13 KII62915.1 - 0.046 13.1 0.0 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family Miro PF08477.8 KII62915.1 - 0.06 13.8 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Viral_helicase1 PF01443.13 KII62915.1 - 0.072 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.1 KII62915.1 - 0.083 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_11 PF13086.1 KII62915.1 - 0.094 12.2 3.5 0.22 11.0 0.0 2.5 2 1 1 3 3 3 0 AAA domain AAA_23 PF13476.1 KII62915.1 - 0.098 12.9 0.3 0.098 12.9 0.2 2.1 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.1 KII62915.1 - 0.11 12.6 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.16 KII62915.1 - 0.3 10.3 4.0 0.27 10.4 0.1 2.1 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain Helicase_C PF00271.26 KII62916.1 - 8.5e-08 31.9 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PDZ PF00595.19 KII62918.1 - 4.5e-33 113.2 3.1 1.1e-14 54.3 0.1 3.5 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII62918.1 - 3.9e-13 49.0 0.1 0.00076 19.3 0.0 3.6 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.1 KII62918.1 - 0.0005 19.8 0.1 1.8 8.4 0.0 3.5 3 0 0 3 3 3 2 Tricorn protease PDZ domain HLH PF00010.21 KII62919.1 - 0.01 15.5 0.7 0.023 14.3 0.5 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Cullin PF00888.17 KII62921.1 - 5e-76 256.4 10.5 5e-76 256.4 7.3 1.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.4 KII62921.1 - 2.2e-05 24.2 0.2 0.00011 21.9 0.1 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain EAL PF00563.15 KII62922.1 - 1.5e-28 99.8 0.0 1.9e-28 99.5 0.0 1.0 1 0 0 1 1 1 1 EAL domain PilZ PF07238.9 KII62923.1 - 2.6e-08 33.7 0.0 1e-07 31.8 0.0 2.0 2 0 0 2 2 2 1 PilZ domain DUF4494 PF14902.1 KII62923.1 - 0.24 10.9 2.8 0.36 10.4 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4494) Aldo_ket_red PF00248.16 KII62924.1 - 4.1e-17 61.9 0.0 4.7e-17 61.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PEN-2 PF10251.4 KII62925.1 - 0.038 14.2 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase rve PF00665.21 KII62926.1 - 0.0024 17.9 0.0 0.0046 17.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MVP_shoulder PF11978.3 KII62927.1 - 0.018 14.9 0.8 0.12 12.2 0.1 2.1 2 0 0 2 2 2 0 Shoulder domain DUF4417 PF14386.1 KII62927.1 - 0.045 13.0 0.0 0.074 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) SAPS PF04499.10 KII62929.1 - 5.4e-12 45.1 10.9 1e-07 30.9 1.5 3.4 3 1 1 4 4 4 2 SIT4 phosphatase-associated protein TetR PF13972.1 KII62929.1 - 0.01 15.2 0.4 0.13 11.6 0.0 2.7 3 0 0 3 3 3 0 Bacterial transcriptional repressor DUF89 PF01937.14 KII62930.1 - 1.3e-46 159.0 0.8 2.3e-46 158.2 0.6 1.3 1 1 0 1 1 1 1 Protein of unknown function DUF89 ATP-synt_C PF00137.16 KII62931.1 - 6.6e-12 45.1 13.9 8.5e-12 44.8 9.6 1.1 1 0 0 1 1 1 1 ATP synthase subunit C DUF4371 PF14291.1 KII62936.1 - 1.9e-12 47.2 0.6 6.7e-12 45.4 0.4 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4371) DUF211 PF02680.9 KII62936.1 - 0.16 11.7 1.0 1.2 9.0 0.1 2.7 2 2 0 2 2 2 0 Uncharacterized ArCR, COG1888 HTH_33 PF13592.1 KII62937.1 - 1.5e-05 24.4 0.0 2.3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII62937.1 - 0.00059 19.8 0.0 0.00089 19.2 0.0 1.3 1 0 0 1 1 1 1 Transposase B5 PF03484.10 KII62937.1 - 0.0013 18.4 0.0 0.011 15.5 0.0 2.0 1 1 1 2 2 2 1 tRNA synthetase B5 domain HTH_23 PF13384.1 KII62937.1 - 0.0036 16.8 0.1 1.5 8.5 0.1 2.7 2 1 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII62937.1 - 0.014 15.4 0.0 0.33 11.0 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.1 KII62937.1 - 0.015 14.8 0.0 0.82 9.2 0.0 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_17 PF12728.2 KII62937.1 - 0.065 13.4 0.1 2.4 8.4 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_32 PF13565.1 KII62937.1 - 0.087 13.6 0.0 0.13 13.0 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain HTH_29 PF13551.1 KII62937.1 - 0.092 12.9 0.1 0.15 12.2 0.0 1.5 1 1 0 1 1 1 0 Winged helix-turn helix DALR_2 PF09190.6 KII62937.1 - 0.45 10.8 2.1 0.65 10.2 0.4 2.1 2 1 0 2 2 2 0 DALR domain DDE_3 PF13358.1 KII62938.1 - 0.0021 17.8 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease MRP-L28 PF09812.4 KII62942.1 - 0.026 14.3 0.2 0.033 14.0 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 DegS PF05384.6 KII62943.1 - 0.006 15.8 1.0 0.0091 15.2 0.7 1.3 1 0 0 1 1 1 1 Sensor protein DegS HTH_38 PF13936.1 KII62943.1 - 0.031 13.8 1.4 6.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII62943.1 - 0.085 12.9 0.4 0.15 12.1 0.3 1.4 1 0 0 1 1 1 0 Transposase HTH_5 PF01022.15 KII62943.1 - 0.12 12.0 0.1 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Phage_int_SAM_5 PF13102.1 KII62944.1 - 0.056 13.4 2.1 1.9 8.4 0.0 2.9 2 1 1 3 3 3 0 Phage integrase SAM-like domain MULE PF10551.4 KII62945.1 - 0.017 15.2 0.1 0.048 13.8 0.0 1.7 2 0 0 2 2 2 0 MULE transposase domain zf-UBR PF02207.15 KII62947.1 - 4.9e-12 45.3 17.7 1.3e-11 44.0 12.3 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 KII62947.1 - 0.013 15.1 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS rve PF00665.21 KII62948.1 - 7.3e-31 106.7 0.0 2.8e-30 104.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII62948.1 - 1.3e-22 80.1 0.1 1.3e-21 76.9 0.0 2.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII62948.1 - 0.00013 21.3 0.0 0.00035 20.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII62948.1 - 0.16 11.3 1.2 0.45 9.9 0.8 1.8 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger Peptidase_S24 PF00717.18 KII62948.1 - 0.2 11.3 1.3 1.8 8.2 0.0 2.8 3 0 0 3 3 3 0 Peptidase S24-like CLASP_N PF12348.3 KII62950.1 - 0.013 14.8 0.1 0.2 10.9 0.0 2.1 2 0 0 2 2 2 0 CLASP N terminal Septin PF00735.13 KII62950.1 - 0.14 11.1 0.1 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Septin DUF2562 PF10814.3 KII62951.1 - 0.17 11.8 0.0 0.6 10.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2562) Dynamin_M PF01031.15 KII62952.1 - 3.5e-32 111.3 0.1 5.5e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 KII62952.1 - 3e-17 62.9 0.1 5.1e-17 62.1 0.1 1.4 1 0 0 1 1 1 1 Dynamin family DUF3292 PF11696.3 KII62952.1 - 0.0049 14.8 0.0 0.0064 14.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) Baculo_p74 PF04583.7 KII62952.1 - 0.088 11.9 0.1 0.16 11.1 0.1 1.4 1 0 0 1 1 1 0 Baculoviridae p74 conserved region TMEM37 PF15108.1 KII62953.1 - 0.0035 17.0 0.4 0.068 12.8 0.0 2.1 2 0 0 2 2 2 1 Voltage-dependent calcium channel gamma-like subunit protein family YebO PF13974.1 KII62953.1 - 0.014 15.1 0.6 0.014 15.1 0.4 1.8 2 0 0 2 2 2 0 YebO-like protein DUF912 PF06024.7 KII62953.1 - 0.027 14.5 0.8 0.033 14.2 0.1 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) VSP PF03302.8 KII62953.1 - 0.034 12.7 0.3 0.044 12.4 0.2 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Strabismus PF06638.6 KII62953.1 - 0.045 12.0 0.0 0.057 11.7 0.0 1.1 1 0 0 1 1 1 0 Strabismus protein Podoplanin PF05808.6 KII62953.1 - 0.74 9.3 5.3 1.9 8.0 3.7 1.6 1 1 0 1 1 1 0 Podoplanin PLDc_N PF13396.1 KII62953.1 - 1.8 8.3 9.6 2.3 7.9 5.9 1.8 1 1 0 1 1 1 0 Phospholipase_D-nuclease N-terminal Tic20 PF09685.5 KII62953.1 - 8.9 6.3 8.7 0.74 9.8 2.6 1.7 2 1 0 2 2 2 0 Tic20-like protein DUF912 PF06024.7 KII62955.1 - 0.021 14.8 0.1 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) OAD_gamma PF04277.8 KII62955.1 - 0.057 13.8 0.4 0.1 12.9 0.2 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain RseC_MucC PF04246.7 KII62955.1 - 0.058 12.9 0.8 0.084 12.4 0.6 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC DUF4234 PF14018.1 KII62955.1 - 0.069 12.9 0.1 0.086 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) Herpes_gE PF02480.11 KII62955.1 - 0.098 10.8 0.0 0.11 10.7 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Myc_target_1 PF15179.1 KII62955.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Myc target protein 1 DUF3040 PF11239.3 KII62955.1 - 0.15 12.1 0.4 0.3 11.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) YebO PF13974.1 KII62955.1 - 0.78 9.5 5.4 2.9 7.7 3.7 2.0 1 1 0 1 1 1 0 YebO-like protein PLDc_N PF13396.1 KII62955.1 - 7.9 6.2 12.2 3.2 7.4 6.4 1.8 1 1 1 2 2 2 0 Phospholipase_D-nuclease N-terminal PIG-P PF08510.7 KII62956.1 - 0.049 13.2 0.0 0.065 12.8 0.0 1.2 1 0 0 1 1 1 0 PIG-P BUD22 PF09073.5 KII62957.1 - 0.029 13.4 10.8 0.035 13.1 7.2 1.3 2 0 0 2 2 2 0 BUD22 Cwf_Cwc_15 PF04889.7 KII62957.1 - 0.8 9.3 12.7 0.99 9.0 8.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein KH_1 PF00013.24 KII62959.1 - 8.3e-05 22.1 0.0 0.00014 21.4 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 KII62959.1 - 0.013 15.0 0.1 0.018 14.5 0.1 1.4 1 1 0 1 1 1 0 KH domain KH_3 PF13014.1 KII62959.1 - 0.022 14.3 0.0 0.049 13.3 0.0 1.6 1 0 0 1 1 1 0 KH domain HTH_32 PF13565.1 KII62960.1 - 0.00085 20.0 0.7 0.0017 19.0 0.5 1.5 1 0 0 1 1 1 1 Homeodomain-like domain DDE_3 PF13358.1 KII62960.1 - 0.0031 17.2 0.1 0.0076 16.0 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease Sugar_tr PF00083.19 KII62962.1 - 2.3e-51 174.7 31.9 2.8e-51 174.5 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII62962.1 - 7.4e-20 70.9 21.4 7.4e-20 70.9 14.9 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily DDE_3 PF13358.1 KII62963.1 - 6.3e-05 22.7 0.1 0.0012 18.6 0.1 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease Peptidase_M3 PF01432.15 KII62964.1 - 9.3e-44 150.2 1.2 1.2e-43 149.8 0.8 1.0 1 0 0 1 1 1 1 Peptidase family M3 Skp1_POZ PF03931.10 KII62966.1 - 5.9e-10 39.0 0.0 9.5e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain DUF1632 PF07857.7 KII62967.1 - 0.011 15.0 0.1 0.013 14.8 0.0 1.1 1 0 0 1 1 1 0 CEO family (DUF1632) RecR PF02132.10 KII62967.1 - 0.072 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 RecR protein DUF4042 PF13251.1 KII62967.1 - 0.09 12.2 0.1 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) Phytoreo_P8 PF07124.6 KII62967.1 - 0.1 11.2 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Phytoreovirus outer capsid protein P8 NOB1_Zn_bind PF08772.6 KII62968.1 - 2.6e-12 46.3 2.1 3.5e-12 45.9 1.0 1.6 1 1 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.1 KII62968.1 - 0.0037 16.6 1.5 0.0087 15.5 1.0 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 KII62968.1 - 0.0039 16.3 1.4 0.0071 15.5 0.9 1.5 1 0 0 1 1 1 1 zinc-ribbon domain zf-C2HC5 PF06221.8 KII62968.1 - 0.036 13.8 0.2 0.067 12.9 0.1 1.4 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type DZR PF12773.2 KII62968.1 - 0.047 13.5 0.3 0.075 12.8 0.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon DUF4256 PF14066.1 KII62968.1 - 0.066 12.7 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4256) Cript PF10235.4 KII62968.1 - 0.19 12.1 1.9 0.31 11.4 0.2 2.0 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT zf-C4_ClpX PF06689.8 KII62968.1 - 4.7 6.8 7.8 2.3 7.7 0.7 2.6 2 1 1 3 3 3 0 ClpX C4-type zinc finger Pneumo_att_G PF05539.6 KII62969.1 - 2 7.6 6.7 2.4 7.4 4.7 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DNA_ligase_A_N PF04675.9 KII62970.1 - 0.0033 17.2 0.0 0.0047 16.7 0.0 1.2 1 0 0 1 1 1 1 DNA ligase N terminus Miro PF08477.8 KII62971.1 - 0.0012 19.3 0.0 0.0015 19.0 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 KII62971.1 - 0.009 15.4 0.1 0.02 14.2 0.0 1.5 1 1 1 2 2 2 1 Ras family EF_assoc_2 PF08356.7 KII62972.1 - 9.8e-07 28.4 0.0 1.5e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 EF hand associated EF-hand_7 PF13499.1 KII62972.1 - 8e-06 25.9 1.5 3.2e-05 23.9 1.0 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KII62972.1 - 1.4e-05 24.0 2.5 0.00015 20.8 0.7 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KII62972.1 - 7.9e-05 22.2 1.3 0.00044 19.9 0.5 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KII62972.1 - 0.0005 19.2 2.3 0.0019 17.4 0.3 2.8 3 2 1 4 4 4 1 EF hand EF-hand_8 PF13833.1 KII62972.1 - 0.0093 15.5 1.7 0.95 9.1 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair Miro PF08477.8 KII62973.1 - 6.8e-12 45.9 0.0 1.1e-11 45.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 KII62973.1 - 7.5e-06 25.4 0.6 8e-05 22.0 0.4 2.4 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 KII62973.1 - 0.00058 19.7 0.0 0.0009 19.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.1 KII62973.1 - 0.0028 17.2 0.1 0.0043 16.6 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 KII62973.1 - 0.0081 16.3 0.0 0.015 15.4 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 KII62973.1 - 0.041 13.4 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.4 KII62973.1 - 0.051 13.0 0.2 0.33 10.4 0.2 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.1 KII62973.1 - 0.092 12.1 0.1 0.22 10.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KII62973.1 - 0.094 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.12 KII62973.1 - 0.1 11.9 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF258 PF03193.11 KII62973.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_28 PF13521.1 KII62973.1 - 0.13 12.2 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 KII62973.1 - 0.15 10.9 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) FGGY_C PF02782.11 KII62975.1 - 0.00028 20.5 0.0 0.0011 18.6 0.0 1.7 1 1 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain YadA_anchor PF03895.10 KII62975.1 - 0.14 12.2 0.1 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 YadA-like C-terminal region Ribosomal_L14 PF00238.14 KII62976.1 - 1.3e-32 112.0 1.0 1.5e-32 111.9 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Pkinase PF00069.20 KII62977.1 - 1.1e-15 57.5 0.0 1.2e-15 57.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII62977.1 - 1.6e-07 30.7 0.0 1.9e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Baculo_RING PF05883.6 KII62977.1 - 0.0025 17.6 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain RRM_1 PF00076.17 KII62978.1 - 3.1e-16 58.7 0.0 5.4e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII62978.1 - 5.2e-11 42.3 0.0 8.9e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII62978.1 - 1.2e-08 34.6 0.6 2.5e-08 33.6 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3791 PF12668.2 KII62978.1 - 0.049 13.2 0.0 1.6 8.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) Sof1 PF04158.9 KII62978.1 - 0.19 11.7 1.4 7.2 6.7 0.5 2.3 2 0 0 2 2 2 0 Sof1-like domain Skp1 PF01466.14 KII62979.1 - 0.69 9.9 2.5 6.6 6.8 0.1 2.4 2 0 0 2 2 2 0 Skp1 family, dimerisation domain GST_C_2 PF13410.1 KII62980.1 - 4.2e-08 32.9 0.0 6.4e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KII62980.1 - 1.4e-07 31.8 0.0 2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KII62980.1 - 1.1e-05 25.3 0.0 2.2e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KII62980.1 - 0.00037 20.6 0.0 0.00082 19.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF4371 PF14291.1 KII62981.1 - 6.5e-06 25.8 0.0 8.4e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) rve PF00665.21 KII62983.1 - 1.2e-15 57.6 0.0 2e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII62983.1 - 0.00023 20.6 0.1 0.00051 19.5 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Sec23_helical PF04815.10 KII62983.1 - 0.052 12.9 0.0 0.08 12.3 0.0 1.5 1 0 0 1 1 1 0 Sec23/Sec24 helical domain DDE_Tnp_IS240 PF13610.1 KII62983.1 - 0.091 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 DDE domain DUF1637 PF07847.7 KII62984.1 - 5.6e-31 107.4 0.1 6.8e-31 107.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1637) CDO_I PF05995.7 KII62984.1 - 0.00095 18.3 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Cysteine dioxygenase type I Histone PF00125.19 KII62986.1 - 2.2e-32 110.9 0.3 3.7e-32 110.2 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KII62986.1 - 0.00027 21.0 0.0 0.00042 20.4 0.0 1.3 1 0 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 KII62986.1 - 0.0048 16.2 1.0 0.0066 15.7 0.7 1.4 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T CBFD_NFYB_HMF PF00808.18 KII62986.1 - 0.0092 16.0 0.0 0.0092 16.0 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Actin PF00022.14 KII62988.1 - 3.6e-92 308.8 0.0 5.9e-92 308.1 0.0 1.2 1 1 0 1 1 1 1 Actin DUF4411 PF14367.1 KII62988.1 - 0.037 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) KilA-N PF04383.8 KII62988.1 - 0.074 12.6 0.2 1.9 8.1 0.0 2.5 3 0 0 3 3 3 0 KilA-N domain Snf7 PF03357.16 KII62989.1 - 1.5e-11 43.9 8.6 1.8e-11 43.7 6.0 1.0 1 0 0 1 1 1 1 Snf7 TAFII28 PF04719.9 KII62989.1 - 0.071 12.9 1.3 0.11 12.2 0.5 1.7 1 1 0 1 1 1 0 hTAFII28-like protein conserved region Med7 PF05983.6 KII62989.1 - 0.18 11.6 3.7 0.25 11.0 2.6 1.4 1 1 0 1 1 1 0 MED7 protein APG6 PF04111.7 KII62989.1 - 0.19 10.7 3.2 0.27 10.2 2.2 1.2 1 1 0 1 1 1 0 Autophagy protein Apg6 CCDC66 PF15236.1 KII62989.1 - 0.26 10.9 6.6 0.34 10.5 4.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 Macoilin PF09726.4 KII62989.1 - 0.26 9.5 3.0 0.28 9.4 2.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Peptidase_C54 PF03416.14 KII62990.1 - 4.7e-23 81.7 0.1 5.1e-23 81.5 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.8 KII62990.1 - 0.002 17.2 0.0 0.0035 16.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.14 KII62991.1 - 2.9e-18 66.0 0.1 3.5e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 DUF155 PF02582.9 KII62992.1 - 0.047 13.6 0.5 0.088 12.7 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 Phage_Mu_Gam PF07352.7 KII62993.1 - 0.013 14.9 4.8 0.017 14.6 3.3 1.0 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein DUF3754 PF12576.3 KII62993.1 - 0.2 11.3 2.4 0.25 10.9 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) DUF1925 PF09094.6 KII62993.1 - 0.43 10.5 4.5 0.58 10.1 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1925) DUF16 PF01519.11 KII62993.1 - 1.6 9.0 5.8 1.8 8.8 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 SWIB PF02201.13 KII62994.1 - 7.4e-11 41.5 0.0 1.7e-10 40.4 0.0 1.6 2 0 0 2 2 2 1 SWIB/MDM2 domain DUF904 PF06005.7 KII62994.1 - 0.021 15.0 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) Fcf2 PF08698.6 KII62995.1 - 1.7 8.6 7.4 1.6 8.7 2.4 2.2 1 1 1 2 2 2 0 Fcf2 pre-rRNA processing DUF4551 PF15087.1 KII62995.1 - 2.1 6.6 12.0 2.3 6.4 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MOR2-PAG1_N PF14222.1 KII62995.1 - 5.3 5.5 11.3 6.6 5.2 7.8 1.0 1 0 0 1 1 1 0 Cell morphogenesis N-terminal EGF_3 PF12947.2 KII62997.1 - 0.012 15.5 3.3 0.012 15.5 2.3 3.4 3 0 0 3 3 3 0 EGF domain EGF_2 PF07974.8 KII62997.1 - 0.02 15.0 10.5 0.02 15.0 7.3 4.0 4 0 0 4 4 4 0 EGF-like domain DUF3132 PF11330.3 KII62997.1 - 0.042 13.6 0.1 0.072 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3132) Serpin PF00079.15 KII63000.1 - 3e-30 105.6 2.7 3.6e-30 105.3 1.9 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Patatin PF01734.17 KII63001.1 - 0.0012 18.7 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase Phytoreo_Pns PF05451.6 KII63001.1 - 0.11 11.1 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns10/11 PRANC PF09372.5 KII63002.1 - 0.0046 16.9 13.3 0.021 14.8 0.5 3.7 3 1 0 3 3 3 2 PRANC domain Defensin_3 PF08131.6 KII63002.1 - 0.029 14.3 0.5 0.074 13.0 0.3 1.7 1 0 0 1 1 1 0 Defensin-like peptide family BNR PF02012.15 KII63004.1 - 0.025 14.3 4.4 2.1 8.4 0.0 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat BNR PF02012.15 KII63005.1 - 7.1e-09 34.1 2.4 0.064 13.1 0.1 4.1 4 0 0 4 4 4 3 BNR/Asp-box repeat Mo-co_dimer PF03404.11 KII63005.1 - 0.049 13.2 0.2 7.8 6.1 0.0 3.1 3 1 1 4 4 4 0 Mo-co oxidoreductase dimerisation domain DUF202 PF02656.10 KII63006.1 - 1.9 8.7 6.8 21 5.4 4.7 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DDE_1 PF03184.14 KII63009.1 - 2.3e-19 69.3 0.0 3.2e-19 68.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Ribosomal_L13e PF01294.13 KII63010.1 - 2.3e-66 222.6 4.4 3e-66 222.2 3.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_L13e PF01294.13 KII63011.1 - 2.3e-66 222.6 4.4 3e-66 222.2 3.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e TPR_14 PF13428.1 KII63012.1 - 1.9e-10 40.3 0.0 5.5 7.9 0.0 8.8 8 2 2 10 10 9 1 Tetratricopeptide repeat TPR_12 PF13424.1 KII63012.1 - 5.3e-08 32.6 0.1 0.0023 17.8 0.0 4.4 4 0 0 4 4 3 1 Tetratricopeptide repeat NRDE-2 PF08424.5 KII63012.1 - 3.2e-06 26.2 10.2 0.00081 18.3 0.1 5.0 4 2 1 5 5 5 2 NRDE-2, necessary for RNA interference TPR_15 PF13429.1 KII63012.1 - 6.9e-06 25.3 0.0 0.049 12.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KII63012.1 - 8.1e-06 25.3 1.0 0.34 10.5 0.0 5.7 7 0 0 7 7 7 1 TPR repeat TPR_16 PF13432.1 KII63012.1 - 4.2e-05 24.0 0.2 0.04 14.6 0.0 4.4 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 KII63012.1 - 8.2e-05 22.8 0.0 0.43 10.9 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 KII63012.1 - 0.00017 21.3 11.0 0.44 10.3 0.0 6.5 7 1 0 8 8 8 1 Mad3/BUB1 homology region 1 RPN7 PF10602.4 KII63012.1 - 0.0024 17.2 0.2 1.3 8.3 0.0 2.7 2 0 0 2 2 2 2 26S proteasome subunit RPN7 TPR_17 PF13431.1 KII63012.1 - 0.0088 16.1 4.2 17 5.8 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII63012.1 - 0.014 15.1 4.8 4.7 7.2 0.0 5.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII63012.1 - 0.017 15.0 12.6 0.6 10.1 0.1 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII63012.1 - 0.25 11.2 3.8 7.9 6.5 0.1 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII63012.1 - 0.75 9.5 4.5 2.6 7.8 0.1 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat PPR PF01535.15 KII63012.1 - 3.3 7.8 6.2 19 5.4 0.1 5.0 5 0 0 5 5 5 0 PPR repeat Wyosine_form PF08608.7 KII63013.1 - 2.1e-19 69.3 0.9 4.9e-19 68.1 0.1 2.1 2 0 0 2 2 2 1 Wyosine base formation Radical_SAM PF04055.16 KII63013.1 - 3.2e-19 69.6 0.0 5.5e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Ldl_recept_a PF00057.13 KII63015.1 - 3.1e-20 71.7 31.5 3e-11 43.0 7.1 2.5 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A SPX PF03105.14 KII63016.1 - 0.0029 17.4 0.1 0.0032 17.3 0.0 1.1 1 0 0 1 1 1 1 SPX domain zf-CCHC PF00098.18 KII63016.1 - 0.017 15.0 0.3 0.017 15.0 0.2 2.2 3 0 0 3 3 3 0 Zinc knuckle gag-asp_proteas PF13975.1 KII63016.1 - 0.031 14.0 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII63016.1 - 1.1 8.9 9.4 5.5 6.7 0.3 2.6 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.22 KII63018.1 - 0.0067 15.8 0.5 0.025 13.9 0.1 2.1 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII63019.1 - 1.1e-24 86.8 0.3 1.4e-24 86.5 0.2 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII63019.1 - 0.004 16.6 0.0 0.0081 15.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_38 PF13936.1 KII63021.1 - 2e-07 30.4 0.0 6e-05 22.5 0.0 2.2 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_29 PF13551.1 KII63021.1 - 1.4e-06 28.4 0.0 1.7e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII63021.1 - 1.5e-06 27.6 0.0 2.7e-06 26.8 0.0 1.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII63021.1 - 3.4e-06 26.9 0.1 6e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.13 KII63021.1 - 0.00022 20.9 0.0 0.00025 20.7 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_7 PF02796.10 KII63021.1 - 0.00048 19.9 0.4 0.0031 17.3 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.11 KII63021.1 - 0.00062 19.4 0.1 0.00075 19.1 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_Crp_2 PF13545.1 KII63021.1 - 0.0012 18.6 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_11 PF08279.7 KII63021.1 - 0.0053 16.3 0.3 0.0078 15.8 0.2 1.3 1 0 0 1 1 1 1 HTH domain HTH_Tnp_1 PF01527.15 KII63021.1 - 0.035 14.0 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 Transposase Sigma70_r4 PF04545.11 KII63021.1 - 0.044 13.0 0.0 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 MarR PF01047.17 KII63021.1 - 0.061 13.0 0.2 0.31 10.7 0.1 2.0 1 1 0 1 1 1 0 MarR family TrmB PF01978.14 KII63021.1 - 0.071 12.8 0.1 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Lant_dehyd_C PF04738.8 KII63023.1 - 0.11 10.6 0.0 0.11 10.6 0.0 1.1 1 0 0 1 1 1 0 Lantibiotic dehydratase, C terminus ATP-synt_8 PF00895.15 KII63024.1 - 0.0023 18.1 0.6 0.0064 16.6 0.4 1.7 1 0 0 1 1 1 1 ATP synthase protein 8 SUR7 PF06687.7 KII63025.1 - 0.18 11.3 3.0 0.18 11.3 1.3 1.5 1 1 1 2 2 2 0 SUR7/PalI family IF-2B PF01008.12 KII63026.1 - 3.8e-40 137.6 0.0 5.2e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family zf-Sec23_Sec24 PF04810.10 KII63027.1 - 0.25 10.9 5.3 0.33 10.5 2.9 1.9 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger FLYWCH PF04500.11 KII63028.1 - 2.3e-10 40.1 0.4 5.2e-10 39.0 0.3 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain H_lectin PF09458.5 KII63028.1 - 0.069 12.8 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 H-type lectin domain Leukocidin PF07968.7 KII63028.1 - 0.11 12.1 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Leukocidin/Hemolysin toxin family Serpin PF00079.15 KII63029.1 - 3.4e-32 111.9 0.4 2.7e-19 69.5 0.1 2.1 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) rve PF00665.21 KII63030.1 - 1.2e-11 44.7 0.0 2.1e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII63031.1 - 4.4e-28 98.1 0.1 6e-28 97.6 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Serpin PF00079.15 KII63032.1 - 5.7e-45 154.0 3.2 6.3e-45 153.9 2.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII63033.1 - 7.2e-37 127.3 3.2 1.2e-36 126.6 2.2 1.3 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII63034.1 - 4.3e-18 65.6 0.0 5.1e-18 65.3 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII63035.1 - 9.2e-42 143.4 1.9 1e-41 143.3 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII63036.1 - 2.8e-51 174.8 6.2 3.3e-51 174.5 4.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Imm23 PF15593.1 KII63036.1 - 0.016 15.4 2.1 0.016 15.4 1.4 2.4 2 1 1 3 3 3 0 Immunity protein 23 Serpin PF00079.15 KII63037.1 - 1.2e-51 175.9 5.2 7.9e-51 173.3 3.6 1.8 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_3 PF13358.1 KII63038.1 - 6e-33 113.6 0.0 8.4e-33 113.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII63038.1 - 0.052 13.6 0.0 0.088 12.9 0.0 1.6 1 1 0 1 1 1 0 Integrase core domain Serpin PF00079.15 KII63039.1 - 1.7e-12 47.1 0.3 1.8e-12 47.1 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII63040.1 - 4e-41 141.3 2.8 4.8e-41 141.1 1.9 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Integrin_beta PF00362.13 KII63041.1 - 9.2e-05 21.5 0.0 0.00013 20.9 0.0 1.2 1 0 0 1 1 1 1 Integrin, beta chain PSI PF01437.20 KII63041.1 - 9.9e-05 22.4 1.5 0.00014 21.9 1.1 1.2 1 0 0 1 1 1 1 Plexin repeat Jiraiya PF15038.1 KII63042.1 - 0.024 14.0 0.6 0.027 13.9 0.4 1.2 1 0 0 1 1 1 0 Jiraiya Thioredoxin PF00085.15 KII63044.1 - 1.2e-28 98.8 0.2 7.6e-23 80.1 0.0 3.3 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.1 KII63044.1 - 1.8e-07 31.1 0.9 5e-06 26.4 0.1 2.7 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_2 PF13098.1 KII63044.1 - 5.2e-07 29.8 0.2 0.011 15.9 0.1 3.7 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KII63044.1 - 0.0015 18.6 1.0 0.52 10.4 0.0 3.6 3 1 0 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.1 KII63044.1 - 0.0015 18.4 0.0 0.012 15.5 0.0 2.3 3 0 0 3 3 3 1 Thioredoxin-like HyaE PF07449.6 KII63044.1 - 0.019 14.8 0.0 11 5.9 0.0 3.2 3 1 0 3 3 3 0 Hydrogenase-1 expression protein HyaE EDR1 PF14381.1 KII63044.1 - 0.09 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 GBS_Bsp-like PF08481.5 KII63045.1 - 0.11 12.3 1.1 0.17 11.7 0.7 1.4 1 1 0 1 1 1 0 GBS Bsp-like repeat AAA_23 PF13476.1 KII63046.1 - 0.046 14.0 0.1 0.064 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Integrin_beta PF00362.13 KII63047.1 - 6.5e-15 54.9 0.0 7.2e-15 54.8 0.0 1.0 1 0 0 1 1 1 1 Integrin, beta chain Anp1 PF03452.9 KII63047.1 - 0.028 13.5 0.0 0.028 13.5 0.0 1.1 1 0 0 1 1 1 0 Anp1 P5-ATPase PF12409.3 KII63047.1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 P5-type ATPase cation transporter PSI PF01437.20 KII63048.1 - 0.2 11.8 5.7 0.43 10.7 4.0 1.7 1 1 0 1 1 1 0 Plexin repeat EGF_2 PF07974.8 KII63049.1 - 7.1e-07 29.2 54.7 0.0013 18.8 9.4 3.7 3 0 0 3 3 3 3 EGF-like domain Ovate PF04844.8 KII63050.1 - 0.081 12.7 1.0 0.18 11.5 0.1 2.0 2 0 0 2 2 2 0 Transcriptional repressor, ovate Kelch_6 PF13964.1 KII63052.1 - 1.7e-07 31.1 2.9 0.00014 21.8 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 KII63052.1 - 2e-07 30.4 1.0 1.6e-06 27.5 0.0 2.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 KII63052.1 - 2.7e-06 27.0 2.1 9.1e-05 22.1 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.1 KII63052.1 - 0.00026 21.0 0.3 0.0061 16.6 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII63052.1 - 0.002 17.8 0.7 0.0066 16.1 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.1 KII63052.1 - 0.006 16.5 0.9 0.024 14.5 0.1 2.3 2 0 0 2 2 2 1 Kelch motif DDE_Tnp_IS1595 PF12762.2 KII63054.1 - 9.7e-06 25.4 0.0 1.8e-05 24.6 0.0 1.4 1 1 1 2 2 2 1 ISXO2-like transposase domain Kelch_6 PF13964.1 KII63055.1 - 5.6e-23 80.1 14.7 5.1e-05 23.2 0.2 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII63055.1 - 2.9e-19 68.3 12.6 2.9e-05 23.5 0.1 6.7 7 0 0 7 7 7 5 Kelch motif Kelch_4 PF13418.1 KII63055.1 - 1.1e-17 63.4 21.4 0.00018 21.2 0.1 6.4 4 1 2 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII63055.1 - 3.5e-16 58.8 10.1 0.0051 16.9 0.1 7.0 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KII63055.1 - 2.4e-08 33.4 17.5 0.041 13.6 0.0 6.5 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 KII63055.1 - 4.8e-08 32.7 7.9 0.038 13.9 0.0 5.3 5 0 0 5 5 5 3 Kelch motif PQQ_3 PF13570.1 KII63055.1 - 0.013 15.7 0.9 29 5.1 0.0 3.9 4 1 0 4 4 4 0 PQQ-like domain Kelch_6 PF13964.1 KII63056.1 - 4e-25 86.8 16.1 3.3e-05 23.8 0.0 6.3 6 1 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII63056.1 - 3.7e-23 80.7 12.7 1.1e-05 24.8 0.1 5.7 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 KII63056.1 - 8e-15 54.5 9.3 0.0017 18.4 0.0 7.2 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.1 KII63056.1 - 8e-15 54.3 14.7 0.0019 17.9 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII63056.1 - 1.6e-14 53.4 13.7 0.00031 20.6 0.1 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KII63056.1 - 9e-10 37.9 12.0 0.27 11.0 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 KII63057.1 - 9.6e-25 85.6 18.1 2.2e-06 27.5 0.1 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII63057.1 - 5.6e-21 73.8 21.1 1.5e-09 37.2 0.2 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII63057.1 - 2.8e-18 65.4 16.6 8.2e-05 22.3 0.1 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII63057.1 - 1.2e-17 63.5 9.8 0.00019 21.4 0.0 6.3 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KII63057.1 - 1.9e-10 40.4 15.3 9.3e-05 22.2 0.0 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 KII63057.1 - 1.6e-09 37.1 13.2 0.00077 19.1 0.1 5.9 6 0 0 6 6 6 3 Kelch motif DUF4256 PF14066.1 KII63057.1 - 0.16 11.4 1.7 4.6 6.6 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4256) Orthoreo_P17 PF07272.6 KII63060.1 - 0.041 13.6 0.1 0.048 13.4 0.1 1.2 1 0 0 1 1 1 0 Orthoreovirus P17 protein DDE_3 PF13358.1 KII63062.1 - 2.3e-07 30.6 0.0 3.7e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII63062.1 - 0.0078 15.7 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix AAA_21 PF13304.1 KII63062.1 - 0.02 14.9 0.3 0.025 14.5 0.2 1.0 1 0 0 1 1 1 0 AAA domain XPG_N PF00752.12 KII63064.1 - 1.9e-22 79.4 0.0 4.1e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 KII63064.1 - 8.1e-22 77.0 0.3 1.6e-21 76.1 0.2 1.5 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.2 KII63064.1 - 7.9e-05 22.2 1.4 0.0001 21.9 0.6 1.4 1 1 0 1 1 1 1 XPG domain containing TPR_11 PF13414.1 KII63064.1 - 0.0035 16.9 0.0 0.006 16.1 0.0 1.3 1 0 0 1 1 1 1 TPR repeat MtrE PF04206.7 KII63066.1 - 0.09 11.7 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E Ldl_recept_a PF00057.13 KII63067.1 - 1.7e-06 27.8 12.3 1.7e-06 27.8 8.5 2.8 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A PS_pyruv_trans PF04230.8 KII63067.1 - 0.041 13.6 0.2 0.065 12.9 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase BNR PF02012.15 KII63068.1 - 9.7e-06 24.6 13.7 1.7 8.8 0.1 5.8 5 0 0 5 5 5 4 BNR/Asp-box repeat BNR_2 PF13088.1 KII63068.1 - 0.054 12.7 0.6 19 4.4 0.0 3.2 2 1 0 3 3 3 0 BNR repeat-like domain DDE_Tnp_IS1595 PF12762.2 KII63070.1 - 2.9e-15 56.3 0.2 1.6e-14 53.9 0.1 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain Zn_ribbon_recom PF13408.1 KII63070.1 - 0.16 12.2 3.5 0.39 11.0 2.4 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain BNR PF02012.15 KII63073.1 - 0.0071 15.9 9.3 0.87 9.6 0.1 3.6 3 0 0 3 3 3 3 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII63074.1 - 2e-07 30.8 10.6 2e-07 30.8 7.4 2.9 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A PS_pyruv_trans PF04230.8 KII63074.1 - 0.051 13.2 0.2 0.09 12.4 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase Ldl_recept_a PF00057.13 KII63075.1 - 5.9e-09 35.6 11.8 5.9e-09 35.6 8.2 2.4 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Caldesmon PF02029.10 KII63076.1 - 0.11 10.9 0.3 0.14 10.5 0.2 1.1 1 0 0 1 1 1 0 Caldesmon DUF4349 PF14257.1 KII63076.1 - 0.12 11.6 0.2 0.22 10.6 0.1 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) HTH_32 PF13565.1 KII63078.1 - 3.7e-05 24.4 0.3 6.3e-05 23.6 0.2 1.4 1 1 1 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII63078.1 - 0.00044 19.9 0.3 0.00051 19.7 0.2 1.2 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc3_2 PF01498.13 KII63078.1 - 0.0019 18.2 0.1 0.0046 16.9 0.1 1.6 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.1 KII63078.1 - 0.0069 16.0 0.1 0.019 14.6 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII63078.1 - 0.01 15.9 0.1 0.013 15.6 0.0 1.1 1 0 0 1 1 1 0 Winged helix-turn helix HTH_psq PF05225.11 KII63078.1 - 0.053 13.0 0.7 0.13 11.8 0.0 2.0 3 0 0 3 3 3 0 helix-turn-helix, Psq domain HTH_28 PF13518.1 KII63078.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Peptidase_M73 PF12389.3 KII63079.1 - 0.21 11.0 1.9 0.46 9.9 0.3 2.1 2 1 0 2 2 2 0 Camelysin metallo-endopeptidase Reo_sigmaC PF04582.7 KII63080.1 - 0.026 13.6 0.5 0.056 12.6 0.3 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Vac_Fusion PF02346.11 KII63080.1 - 0.026 13.9 0.4 0.09 12.2 0.3 1.9 1 0 0 1 1 1 0 Chordopoxvirus fusion protein Prefoldin_2 PF01920.15 KII63080.1 - 0.048 13.4 1.8 0.11 12.2 0.1 2.3 2 0 0 2 2 2 0 Prefoldin subunit P4Ha_N PF08336.6 KII63080.1 - 0.058 13.2 1.1 0.54 10.0 0.1 2.8 2 1 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Prefoldin PF02996.12 KII63080.1 - 0.068 12.8 2.7 0.13 11.8 0.1 2.5 2 1 0 2 2 2 0 Prefoldin subunit Clat_adaptor_s PF01217.15 KII63082.1 - 0.00044 19.9 0.2 0.00052 19.7 0.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TPR_1 PF00515.23 KII63083.1 - 6.9e-07 28.6 0.3 0.0016 17.9 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII63083.1 - 1.1e-05 24.9 0.1 0.13 12.2 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII63083.1 - 1.6e-05 24.7 1.0 2.8e-05 23.9 0.7 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII63083.1 - 2.5e-05 23.8 0.9 0.0032 17.0 0.2 2.0 1 1 0 2 2 2 1 TPR repeat TPR_8 PF13181.1 KII63083.1 - 0.018 14.8 0.2 0.3 10.9 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3969 PF13108.1 KII63083.1 - 0.043 13.4 0.0 0.081 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3969) TPR_10 PF13374.1 KII63083.1 - 0.056 13.4 0.2 1.1 9.3 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII63083.1 - 0.087 12.6 0.1 0.49 10.3 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 KII63083.1 - 0.11 12.5 0.5 0.59 10.2 0.5 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 KII63083.1 - 0.13 12.5 0.2 4.1 7.8 0.0 2.6 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 KII63083.1 - 0.15 12.4 0.0 0.33 11.3 0.0 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII63084.1 - 5.6e-06 25.9 0.0 8.3e-05 22.1 0.0 2.4 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.1 KII63084.1 - 7.4e-06 25.8 0.0 0.013 15.3 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII63084.1 - 0.00011 21.7 0.0 0.25 11.3 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KII63084.1 - 0.00022 20.6 0.0 0.051 13.2 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KII63084.1 - 0.00095 18.7 0.0 0.42 10.5 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 KII63084.1 - 0.016 15.8 0.0 0.028 15.0 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Apc3 PF12895.2 KII63085.1 - 1.2e-06 28.5 0.8 1.2e-06 28.5 0.6 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 HTH_33 PF13592.1 KII63086.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix DUF2315 PF10231.4 KII63088.1 - 4.7e-12 45.8 2.9 5.9e-12 45.5 2.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2315) ADAM_CR PF08516.7 KII63089.1 - 1.2e-16 60.8 12.2 1.2e-16 60.8 8.5 3.2 2 1 1 3 3 3 3 ADAM cysteine-rich OATP PF03137.15 KII63090.1 - 3.4e-28 98.0 12.8 9.6e-28 96.5 8.9 1.6 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII63090.1 - 2.7e-11 42.8 4.2 4.5e-11 42.0 2.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily TMEM154 PF15102.1 KII63090.1 - 0.15 11.7 0.1 0.37 10.4 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family UPF0233 PF06781.7 KII63090.1 - 0.85 9.2 3.8 0.92 9.1 0.2 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0233) Neurensin PF14927.1 KII63090.1 - 7.3 5.9 9.5 11 5.3 0.1 3.2 1 1 2 3 3 3 0 Neurensin OATP PF03137.15 KII63091.1 - 3e-09 35.5 0.1 3.3e-09 35.3 0.1 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF3816 PF12822.2 KII63091.1 - 0.0022 17.9 0.4 0.0024 17.7 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3816) MFS_1 PF07690.11 KII63091.1 - 0.03 13.0 0.5 0.03 13.0 0.4 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily OATP PF03137.15 KII63092.1 - 7.2e-12 44.1 0.3 7.3e-12 44.1 0.2 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family ENTH PF01417.15 KII63095.1 - 0.00094 19.0 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 ENTH domain OATP PF03137.15 KII63096.1 - 4.3e-23 81.1 19.7 5.5e-22 77.5 13.7 2.2 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII63096.1 - 1e-11 44.1 24.7 1e-07 30.9 7.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.20 KII63097.1 - 1.1e-40 139.4 0.0 1.3e-40 139.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII63097.1 - 2.3e-26 92.4 0.0 2.9e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KII63097.1 - 0.0013 17.8 0.0 0.0022 17.1 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KII63097.1 - 0.0016 17.7 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 KII63097.1 - 0.0032 17.2 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KII63097.1 - 0.016 14.1 0.0 0.046 12.6 0.0 1.7 2 0 0 2 2 2 0 Kinase-like OATP PF03137.15 KII63098.1 - 1.2e-05 23.5 1.8 1.5e-05 23.3 1.3 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Pox_G7 PF05503.7 KII63098.1 - 0.015 13.8 0.1 0.022 13.3 0.1 1.1 1 0 0 1 1 1 0 Poxvirus G7-like OATP PF03137.15 KII63102.1 - 2.4e-48 164.5 14.1 2.6e-48 164.4 8.8 1.7 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII63102.1 - 9.9e-16 57.3 4.2 9.9e-16 57.3 2.9 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily Kazal_1 PF00050.16 KII63102.1 - 0.011 15.7 2.8 0.03 14.3 1.9 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.10 KII63102.1 - 0.012 15.5 4.3 0.029 14.2 3.0 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain ATP-synt_8 PF00895.15 KII63102.1 - 1.8 8.8 5.8 0.29 11.3 0.4 2.6 2 0 0 2 2 2 0 ATP synthase protein 8 DUF2075 PF09848.4 KII63103.1 - 0.12 11.3 0.9 6.1 5.7 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DDE_Tnp_IS1595 PF12762.2 KII63105.1 - 1.3e-17 64.0 0.0 1.7e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Fun_ATP-synt_8 PF05933.8 KII63106.1 - 0.72 9.9 4.6 1.2 9.1 3.2 1.5 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) AgrB PF04647.10 KII63110.1 - 0.015 14.3 8.8 0.018 14.1 6.1 1.1 1 0 0 1 1 1 0 Accessory gene regulator B PIG-P PF08510.7 KII63110.1 - 0.016 14.8 1.5 0.023 14.3 0.1 1.7 1 1 1 2 2 2 0 PIG-P DUF3098 PF11297.3 KII63110.1 - 0.28 10.9 4.2 0.41 10.3 2.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3098) DUF2500 PF10694.4 KII63110.1 - 1.2 9.2 3.5 19 5.3 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2500) BNR PF02012.15 KII63113.1 - 0.00059 19.2 4.2 3.3 7.9 0.0 4.4 4 0 0 4 4 4 3 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII63113.1 - 0.0017 18.2 23.4 0.0017 18.2 11.0 2.8 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A Serpin PF00079.15 KII63115.1 - 5.8e-45 154.0 2.2 6.8e-45 153.7 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII63116.1 - 1.2e-33 116.7 2.6 1.5e-33 116.4 1.8 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) NYD-SP28_assoc PF14775.1 KII63119.1 - 0.27 10.9 2.5 1.4 8.6 0.0 2.8 3 0 0 3 3 3 0 Sperm tail C-terminal domain zf-UBR PF02207.15 KII63125.1 - 2.5e-11 43.1 13.1 6.7e-11 41.7 9.1 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) CcmD PF04995.9 KII63128.1 - 0.024 14.3 0.1 0.044 13.5 0.1 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF3888 PF13027.1 KII63131.1 - 0.078 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) HTH_23 PF13384.1 KII63133.1 - 0.059 13.0 0.1 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain ASL_C PF08328.6 KII63133.1 - 0.12 12.1 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal DDE_3 PF13358.1 KII63134.1 - 3.7e-09 36.4 0.0 7.7e-09 35.4 0.0 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF727 PF05303.7 KII63136.1 - 0.029 14.1 0.9 0.039 13.7 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF727) TrmB PF01978.14 KII63136.1 - 0.042 13.5 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Hormone_6 PF00236.13 KII63136.1 - 0.056 13.2 0.9 0.11 12.2 0.2 1.8 1 1 1 2 2 2 0 Glycoprotein hormone HTH_23 PF13384.1 KII63136.1 - 0.058 13.0 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain GerE PF00196.14 KII63136.1 - 0.076 12.3 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family Enolase_N PF03952.11 KII63139.1 - 0.15 11.9 0.1 0.78 9.6 0.0 2.2 3 0 0 3 3 3 0 Enolase, N-terminal domain SHS2_Rpb7-N PF03876.12 KII63140.1 - 4.6e-12 45.8 0.1 6.9e-12 45.3 0.1 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.7 KII63140.1 - 3.9e-11 43.1 0.4 3.8e-10 40.0 0.1 2.5 2 1 0 2 2 2 1 RNA polymerase III subunit Rpc25 S1 PF00575.18 KII63140.1 - 0.02 14.9 0.5 5.8 7.0 0.0 3.0 3 0 0 3 3 3 0 S1 RNA binding domain WD40 PF00400.27 KII63141.1 - 2.9e-49 163.2 29.2 1.7e-11 43.5 0.3 7.9 8 1 0 8 8 8 7 WD domain, G-beta repeat Hydrolase_3 PF08282.7 KII63144.1 - 0.0027 17.3 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KII63144.1 - 0.05 13.7 0.1 0.13 12.4 0.0 1.7 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII63145.1 - 2.2e-10 40.3 0.1 1.9e-09 37.3 0.1 2.2 2 1 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 KII63145.1 - 9.7e-07 29.4 0.0 1.2e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KII63145.1 - 1.3e-05 25.5 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF87 PF01935.12 KII63145.1 - 0.02 14.6 0.0 0.035 13.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function DUF87 HAD_2 PF13419.1 KII63145.1 - 0.035 14.3 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase 3H PF02829.9 KII63145.1 - 0.042 13.8 0.0 0.093 12.7 0.0 1.6 1 1 0 1 1 1 0 3H domain DUF3910 PF13049.1 KII63145.1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3910) E1-E2_ATPase PF00122.15 KII63146.1 - 5.4e-09 35.4 0.0 1.3e-08 34.1 0.0 1.6 2 0 0 2 2 2 1 E1-E2 ATPase Toxin_59 PF15537.1 KII63147.1 - 0.02 15.0 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Putative toxin 59 HAD PF12710.2 KII63148.1 - 1.8e-09 38.0 0.0 3.3e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KII63148.1 - 4.6e-09 37.0 0.0 6.5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KII63148.1 - 0.00052 19.6 0.0 0.006 16.1 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII63148.1 - 0.064 13.2 0.1 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 Putative hydrolase of sodium-potassium ATPase alpha subunit DUF87 PF01935.12 KII63148.1 - 0.089 12.5 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 3H PF02829.9 KII63148.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 3H domain AT_hook PF02178.14 KII63149.1 - 5.2 7.0 8.9 12 5.9 6.1 1.6 1 0 0 1 1 1 0 AT hook motif Ceramidase PF05875.7 KII63150.1 - 5.5e-48 163.3 6.4 6.8e-48 163.0 4.4 1.0 1 0 0 1 1 1 1 Ceramidase DUF3112 PF11309.3 KII63150.1 - 0.21 11.4 5.5 4.3 7.1 1.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3112) DUF4401 PF14351.1 KII63150.1 - 0.22 10.5 11.7 0.41 9.6 8.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4401) EamA PF00892.15 KII63150.1 - 5.2 7.1 12.4 1.3 9.1 1.9 3.0 1 1 1 3 3 3 0 EamA-like transporter family zf-MYND PF01753.13 KII63152.1 - 7.1e-07 28.9 19.9 1.1e-06 28.3 13.8 1.3 1 0 0 1 1 1 1 MYND finger GlutR_dimer PF00745.15 KII63152.1 - 0.036 13.9 0.3 0.063 13.2 0.2 1.3 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF2607 PF10795.4 KII63152.1 - 0.19 11.5 2.0 0.17 11.7 0.4 1.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2607) LRR_4 PF12799.2 KII63153.1 - 6.2e-26 89.5 43.6 2.6e-09 36.5 3.1 4.1 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KII63153.1 - 2.3e-25 88.1 22.6 3.3e-10 39.5 4.6 2.7 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 KII63153.1 - 2.7e-18 63.1 21.9 0.0068 16.2 0.3 6.2 6 0 0 6 6 6 6 Leucine Rich Repeat LRR_7 PF13504.1 KII63153.1 - 1.7e-11 42.3 16.2 0.47 10.8 0.1 6.6 6 1 0 6 6 6 4 Leucine rich repeat LRR_6 PF13516.1 KII63153.1 - 1.2e-07 31.0 23.1 0.16 12.0 0.0 6.3 5 1 1 6 6 6 4 Leucine Rich repeat LRR_5 PF13306.1 KII63153.1 - 0.0035 17.0 6.1 0.024 14.3 2.1 1.9 1 1 1 2 2 2 1 Leucine rich repeats (6 copies) LRR_9 PF14580.1 KII63153.1 - 0.0036 16.8 7.1 0.0051 16.3 0.8 2.1 1 1 1 2 2 2 1 Leucine-rich repeat Baculo_PEP_N PF04512.7 KII63153.1 - 0.71 9.8 10.2 18 5.4 0.3 4.4 1 1 3 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, N terminus SNAP PF14938.1 KII63154.1 - 3.3e-07 29.7 1.1 3.5e-07 29.6 0.7 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.1 KII63154.1 - 0.00013 21.5 3.2 0.014 15.1 0.4 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII63154.1 - 0.00032 20.5 0.4 0.059 13.3 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 KII63154.1 - 0.00061 19.3 0.4 0.047 13.4 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII63154.1 - 0.00088 18.7 2.1 0.58 9.8 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII63154.1 - 0.00089 18.9 1.3 1.8 8.6 0.1 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KII63154.1 - 0.043 13.4 4.0 0.37 10.4 0.2 2.8 2 1 1 3 3 3 0 TPR repeat NSF PF02071.15 KII63154.1 - 2.7 8.9 5.0 65 4.8 0.5 3.8 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat SNAP PF14938.1 KII63155.1 - 0.00055 19.1 1.2 0.00058 19.0 0.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Phage_connect_1 PF05135.8 KII63155.1 - 0.31 11.2 4.0 0.59 10.3 2.7 1.5 1 1 0 1 1 1 0 Phage gp6-like head-tail connector protein RnaseA PF00074.15 KII63156.1 - 0.027 14.7 1.0 0.04 14.2 0.7 1.2 1 0 0 1 1 1 0 Pancreatic ribonuclease DIX PF00778.12 KII63157.1 - 5.3e-09 35.6 0.0 1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 DIX domain Fig1 PF12351.3 KII63160.1 - 1.2 9.0 4.9 1.8 8.3 3.4 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 HSP70 PF00012.15 KII63161.1 - 6.4e-225 747.6 3.8 7.3e-225 747.4 2.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KII63161.1 - 6.1e-20 71.0 1.5 4.4e-17 61.6 0.4 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 KII63161.1 - 0.013 15.1 0.0 0.033 13.8 0.0 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 KII63161.1 - 0.04 13.7 3.7 5.1 6.9 0.1 3.7 2 2 0 2 2 2 0 Cell division protein FtsA DUF4163 PF13739.1 KII63161.1 - 5.3 7.8 6.3 12 6.8 0.7 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4163) UCH PF00443.24 KII63162.1 - 7.7e-16 58.0 0.0 8.3e-16 57.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KII63162.1 - 0.00019 20.9 0.0 0.00022 20.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF3573 PF12097.3 KII63163.1 - 1.2 7.7 5.4 1.8 7.1 3.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) NDK PF00334.14 KII63164.1 - 3.4e-52 175.8 0.0 3.9e-52 175.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase TPR_11 PF13414.1 KII63169.1 - 7.4e-26 89.5 15.8 2.3e-12 46.3 0.4 2.3 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 KII63169.1 - 9.9e-15 53.4 9.3 1.5e-05 24.3 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KII63169.1 - 9.1e-14 50.2 6.8 0.00057 19.6 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 KII63169.1 - 1e-07 31.7 7.1 2.7e-06 27.2 0.9 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII63169.1 - 0.00028 20.4 1.9 0.7 9.8 0.0 3.5 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 KII63169.1 - 0.0028 17.3 0.6 0.71 9.8 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 KII63169.1 - 0.0044 17.1 2.3 0.01 15.9 0.9 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 KII63169.1 - 0.0055 16.8 3.4 0.39 11.0 0.0 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 KII63169.1 - 0.019 14.8 0.0 4.9 7.0 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat NYD-SP12_N PF15015.1 KII63169.1 - 0.022 12.9 0.3 0.036 12.3 0.2 1.5 1 1 0 1 1 1 0 Spermatogenesis-associated, N-terminal TPR_14 PF13428.1 KII63169.1 - 0.035 14.7 0.0 2.3 9.0 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat ArsR PF09824.4 KII63169.1 - 0.039 13.2 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 ArsR transcriptional regulator Cystatin PF00031.16 KII63170.1 - 0.0049 16.9 0.1 0.0058 16.7 0.1 1.2 1 0 0 1 1 1 1 Cystatin domain DUF845 PF05820.6 KII63170.1 - 0.044 13.5 0.1 0.053 13.2 0.1 1.2 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF845) DDE_Tnp_IS1595 PF12762.2 KII63171.1 - 5.2e-10 39.3 0.0 1.1e-09 38.3 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain Kelch_3 PF13415.1 KII63171.1 - 0.06 13.5 0.0 2.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Prenyltransf PF01255.14 KII63172.1 - 8.8e-42 142.7 0.4 1e-41 142.4 0.3 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PALP PF00291.20 KII63176.1 - 1.2e-43 149.5 0.0 1.3e-43 149.3 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Methyltransf_12 PF08242.7 KII63176.1 - 0.035 14.5 0.0 0.13 12.7 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain DUF4590 PF15257.1 KII63177.1 - 0.1 12.4 0.3 0.14 11.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4590) SPRY PF00622.23 KII63178.1 - 1.4e-05 25.1 0.2 2.1e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 SPRY domain Tricho_coat PF05892.6 KII63178.1 - 0.07 12.3 0.1 0.092 11.9 0.1 1.1 1 0 0 1 1 1 0 Trichovirus coat protein BLOC1_2 PF10046.4 KII63179.1 - 0.0088 16.1 0.3 0.014 15.5 0.2 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 RBD-FIP PF09457.5 KII63179.1 - 0.015 15.0 0.5 0.031 14.0 0.3 1.5 1 0 0 1 1 1 0 FIP domain DUF3829 PF12889.2 KII63179.1 - 0.11 11.7 1.1 0.13 11.4 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) DDE_3 PF13358.1 KII63180.1 - 6.1e-09 35.7 0.0 7.1e-09 35.5 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease P4Ha_N PF08336.6 KII63181.1 - 3e-12 46.5 0.6 1.1e-11 44.6 0.0 2.2 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_12 PF13424.1 KII63181.1 - 0.00042 20.1 0.0 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII63181.1 - 0.0058 16.4 0.0 0.029 14.2 0.0 2.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII63181.1 - 0.009 15.6 0.0 0.023 14.3 0.0 1.7 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 KII63181.1 - 0.03 13.9 0.0 0.2 11.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1086 PF06461.6 KII63181.1 - 0.051 13.3 0.0 2.4 7.9 0.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1086) DUF616 PF04765.8 KII63182.1 - 0.084 12.0 0.1 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF616) NuiA PF07924.6 KII63183.1 - 0.07 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein Ribonuc_P_40 PF08584.6 KII63184.1 - 0.07 12.1 0.6 0.084 11.8 0.4 1.1 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit DUF3677 PF12432.3 KII63184.1 - 0.11 12.9 0.2 0.16 12.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3677) FYVE PF01363.16 KII63186.1 - 7.1e-13 48.2 5.3 1.3e-12 47.3 3.7 1.5 1 0 0 1 1 1 1 FYVE zinc finger Fib_alpha PF08702.5 KII63186.1 - 0.0069 16.5 9.6 0.0069 16.5 6.6 3.6 1 1 1 3 3 3 1 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 KII63186.1 - 0.009 15.7 5.1 0.009 15.7 3.5 3.1 3 0 0 3 3 3 2 TATA element modulatory factor 1 DNA binding Phage_GPO PF05929.6 KII63186.1 - 0.027 13.7 8.0 0.042 13.1 5.1 1.6 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase CO_deh_flav_C PF03450.12 KII63186.1 - 0.037 13.9 0.0 0.49 10.3 0.0 2.3 1 1 0 2 2 2 0 CO dehydrogenase flavoprotein C-terminal domain DUF641 PF04859.7 KII63186.1 - 0.053 13.2 13.8 0.026 14.2 2.6 3.0 2 1 0 3 3 3 0 Plant protein of unknown function (DUF641) Peptidase_S46 PF10459.4 KII63186.1 - 0.11 10.8 7.7 0.16 10.3 5.3 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF1409 PF07197.7 KII63186.1 - 0.21 11.7 10.4 0.38 10.8 0.5 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1409) DUF4618 PF15397.1 KII63186.1 - 0.66 9.2 23.0 0.13 11.5 12.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Sec8_exocyst PF04048.9 KII63186.1 - 4.8 6.8 18.6 0.24 11.0 5.2 3.5 1 1 0 2 2 2 0 Sec8 exocyst complex component specific domain Laminin_II PF06009.7 KII63186.1 - 6.1 6.5 20.5 0.64 9.7 1.6 4.1 2 1 2 4 4 4 0 Laminin Domain II Arc_trans_TRASH PF08394.5 KII63188.1 - 0.015 15.4 0.4 0.06 13.5 0.1 2.0 2 0 0 2 2 2 0 Archaeal TRASH domain DDE_Tnp_IS1595 PF12762.2 KII63189.1 - 0.00014 21.6 0.5 0.0021 17.8 0.0 2.3 2 0 0 2 2 2 1 ISXO2-like transposase domain Pox_Ag35 PF03286.9 KII63189.1 - 0.0044 16.5 3.9 0.0064 16.0 2.7 1.2 1 0 0 1 1 1 1 Pox virus Ag35 surface protein Nop53 PF07767.6 KII63189.1 - 0.056 12.4 11.1 0.089 11.7 7.7 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PsiA PF06952.6 KII63189.1 - 0.1 11.6 0.8 0.17 10.9 0.6 1.3 1 0 0 1 1 1 0 PsiA protein FAM176 PF14851.1 KII63189.1 - 0.12 12.0 2.7 0.23 11.1 1.9 1.4 1 0 0 1 1 1 0 FAM176 family BSP_II PF05432.6 KII63189.1 - 0.12 11.6 7.3 0.18 11.0 5.1 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Cas_Csy4 PF09618.5 KII63189.1 - 0.35 10.6 1.9 3 7.6 1.6 2.0 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) NARP1 PF12569.3 KII63189.1 - 0.86 8.2 8.5 1.2 7.7 5.9 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Peptidase_S49_N PF08496.5 KII63189.1 - 1 9.1 4.1 1.5 8.5 2.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Protocadherin PF08374.6 KII63189.1 - 2.6 7.6 5.5 4 7.0 3.8 1.2 1 0 0 1 1 1 0 Protocadherin YqfQ PF14181.1 KII63189.1 - 4.7 7.2 6.4 6.5 6.7 4.4 1.2 1 0 0 1 1 1 0 YqfQ-like protein Ribosomal_60s PF00428.14 KII63189.1 - 5.7 7.4 9.4 9.2 6.7 6.5 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein rve PF00665.21 KII63191.1 - 7.2e-28 97.0 0.0 2.2e-27 95.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII63191.1 - 4e-24 85.1 0.0 7.3e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.5 KII63191.1 - 4.9e-06 25.8 0.2 1.4e-05 24.3 0.2 1.9 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RVP PF00077.15 KII63191.1 - 1.6e-05 24.7 0.1 4.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII63191.1 - 3e-05 23.7 11.4 0.013 15.3 1.9 2.9 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII63191.1 - 0.0017 18.7 0.1 0.0037 17.7 0.1 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII63191.1 - 0.014 15.2 0.0 0.065 13.0 0.0 2.2 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII63191.1 - 0.015 14.9 5.7 0.23 11.1 0.4 3.0 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.9 KII63191.1 - 0.041 13.8 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) rve_3 PF13683.1 KII63191.1 - 0.041 13.4 0.0 0.12 11.9 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain zf-CCHC_6 PF15288.1 KII63191.1 - 0.18 11.4 12.6 1.2 8.8 0.8 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-UBR PF02207.15 KII63193.1 - 1.3e-08 34.4 17.6 2.5e-08 33.4 12.2 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DDE_3 PF13358.1 KII63194.1 - 0.0013 18.4 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII63194.1 - 0.1 12.1 0.1 0.22 11.0 0.0 1.5 2 0 0 2 2 2 0 Winged helix-turn helix ParA PF10609.4 KII63195.1 - 4.6e-32 109.7 1.0 9.2e-32 108.7 0.7 1.5 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 KII63195.1 - 1.3e-15 57.3 0.1 1.8e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 KII63195.1 - 2.7e-10 40.4 0.0 1.5e-09 38.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.10 KII63195.1 - 4.6e-08 32.4 0.3 0.0026 16.8 0.0 2.4 2 0 0 2 2 2 2 Anion-transporting ATPase MipZ PF09140.6 KII63195.1 - 3.7e-07 29.5 0.0 4.8e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 ATPase MipZ Zeta_toxin PF06414.7 KII63195.1 - 0.0026 16.8 0.0 0.6 9.1 0.0 2.1 2 0 0 2 2 2 2 Zeta toxin AAA_26 PF13500.1 KII63195.1 - 0.007 15.9 0.1 1.3 8.6 0.1 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KII63195.1 - 0.039 13.1 0.0 0.087 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 KII63195.1 - 0.079 13.7 0.1 0.13 13.0 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 KII63195.1 - 0.086 13.1 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 KII63195.1 - 0.1 12.9 0.1 0.16 12.2 0.1 1.4 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.17 KII63195.1 - 0.11 12.7 0.1 0.35 11.0 0.0 2.1 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.17 KII63195.1 - 0.16 10.8 1.0 0.18 10.6 0.1 1.4 2 0 0 2 2 2 0 NB-ARC domain DUF1241 PF06840.6 KII63196.1 - 4.6e-09 35.7 0.1 7e-09 35.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Syntaxin_2 PF14523.1 KII63196.1 - 0.0054 16.7 0.1 0.013 15.5 0.1 1.7 1 0 0 1 1 1 1 Syntaxin-like protein HTH_29 PF13551.1 KII63197.1 - 1.8e-05 24.8 0.0 2.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII63197.1 - 4.1e-05 24.2 0.0 7.7e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_33 PF13592.1 KII63197.1 - 0.0014 18.0 0.1 0.0034 16.8 0.0 1.6 1 1 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 KII63197.1 - 0.0086 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 'Paired box' domain CENP-B_dimeris PF09026.5 KII63198.1 - 0.003 17.7 0.2 0.0039 17.4 0.1 1.2 1 0 0 1 1 1 1 Centromere protein B dimerisation domain SUI1 PF01253.17 KII63199.1 - 4.5e-20 71.2 0.1 5.6e-20 70.9 0.0 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.9 KII63199.1 - 0.067 13.4 0.2 0.089 13.0 0.2 1.4 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) Dak2 PF02734.12 KII63200.1 - 0.054 13.1 0.2 0.14 11.8 0.2 1.7 1 0 0 1 1 1 0 DAK2 domain NIF PF03031.13 KII63201.1 - 1.4e-45 154.7 0.3 2.1e-45 154.2 0.2 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Rap_GAP PF02145.10 KII63202.1 - 7.9e-56 188.4 3.3 8.6e-56 188.3 0.4 2.2 2 0 0 2 2 2 1 Rap/ran-GAP E1_DerP2_DerF2 PF02221.10 KII63203.1 - 0.00057 20.1 0.8 0.00067 19.9 0.4 1.3 1 1 0 1 1 1 1 ML domain G-alpha PF00503.15 KII63207.1 - 3.6e-107 358.4 6.9 4.4e-107 358.1 4.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KII63207.1 - 1e-14 54.1 0.2 4.1e-11 42.4 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 KII63207.1 - 0.00013 22.4 0.3 0.098 13.1 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 KII63207.1 - 0.012 14.7 9.4 0.044 12.9 1.5 2.6 2 2 0 2 2 2 0 Gtr1/RagA G protein conserved region DUF498 PF04430.9 KII63207.1 - 0.1 12.1 0.0 0.54 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF498/DUF598) AAA_11 PF13086.1 KII63208.1 - 2.1e-45 155.1 0.2 3.5e-45 154.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII63208.1 - 1.8e-11 43.6 0.0 3.1e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KII63208.1 - 3.2e-11 43.1 0.0 3.2e-08 33.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.1 KII63208.1 - 3e-09 36.5 0.0 9.2e-09 34.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.16 KII63208.1 - 8e-07 28.6 1.6 0.00028 20.2 0.0 2.7 3 0 0 3 3 3 2 UvrD/REP helicase N-terminal domain ResIII PF04851.10 KII63208.1 - 2.3e-05 24.3 0.1 6e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 KII63208.1 - 3.5e-05 22.9 0.1 7.7e-05 21.8 0.1 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.1 KII63208.1 - 4.7e-05 23.8 0.3 4.7e-05 23.8 0.2 2.5 2 1 0 2 2 2 1 AAA domain DEAD PF00270.24 KII63208.1 - 0.00038 19.9 0.1 0.00074 19.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_RecD PF05127.9 KII63208.1 - 0.00059 19.5 0.1 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 Helicase PIF1 PF05970.9 KII63208.1 - 0.0017 17.4 0.1 0.15 11.0 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase AAA_16 PF13191.1 KII63208.1 - 0.0023 17.9 0.0 0.0088 16.0 0.0 2.0 2 1 1 3 3 2 1 AAA ATPase domain AAA PF00004.24 KII63208.1 - 0.0027 17.9 0.1 0.0072 16.5 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.14 KII63208.1 - 0.003 16.8 0.5 0.0059 15.8 0.3 1.4 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain T2SE PF00437.15 KII63208.1 - 0.017 14.0 0.0 0.033 13.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.11 KII63208.1 - 0.035 13.3 0.0 0.099 11.8 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein KaiC PF06745.8 KII63208.1 - 0.06 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 KaiC HAS-barrel PF09378.5 KII63208.1 - 0.063 13.1 0.1 0.18 11.7 0.1 1.8 1 0 0 1 1 1 0 HAS barrel domain IstB_IS21 PF01695.12 KII63208.1 - 0.12 11.8 0.0 0.63 9.4 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.1 KII63208.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_12 PF13087.1 KII63209.1 - 2.8e-33 114.9 0.0 3.2e-33 114.7 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 KII63209.1 - 0.022 14.9 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AroM PF07302.6 KII63209.1 - 0.13 11.5 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 AroM protein DDE_3 PF13358.1 KII63212.1 - 2.4e-24 85.7 0.0 4.4e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII63212.1 - 2.8e-05 24.1 0.0 7.2e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain HTH_23 PF13384.1 KII63212.1 - 0.00017 21.1 0.2 0.0068 16.0 0.1 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII63212.1 - 0.0004 20.5 0.4 0.0009 19.3 0.3 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII63212.1 - 0.00087 19.2 0.4 0.0023 17.9 0.1 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII63212.1 - 0.0076 16.2 0.1 0.016 15.2 0.1 1.5 1 0 0 1 1 1 1 Transposase HTH_38 PF13936.1 KII63212.1 - 0.01 15.3 3.1 1.2 8.6 0.1 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_5 PF01022.15 KII63212.1 - 0.026 14.1 0.1 0.097 12.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family DUF1662 PF07878.6 KII63212.1 - 0.065 12.9 0.2 0.17 11.6 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1662) DUF3071 PF11268.3 KII63212.1 - 0.18 11.5 1.0 0.27 10.9 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Trp_repressor PF01371.14 KII63212.1 - 0.31 10.9 4.1 0.12 12.2 0.8 1.9 2 0 0 2 2 2 0 Trp repressor protein Peptidase_M18 PF02127.10 KII63213.1 - 7.5e-133 443.1 0.1 1.4e-90 303.8 0.1 2.0 1 1 1 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 KII63213.1 - 2.1e-05 23.4 0.0 0.00055 18.7 0.0 2.1 1 1 1 2 2 2 2 M42 glutamyl aminopeptidase HTH_26 PF13443.1 KII63213.1 - 0.032 14.4 0.0 0.074 13.2 0.0 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain WD40 PF00400.27 KII63214.1 - 9.4e-49 161.6 15.6 1.8e-13 49.8 0.2 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.3 KII63214.1 - 5.1e-05 21.6 0.2 0.015 13.4 0.0 3.1 3 0 0 3 3 3 2 Nucleoporin Nup120/160 DUF4165 PF13752.1 KII63214.1 - 0.0059 16.3 0.1 1.1 9.0 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4165) DUF2833 PF11090.3 KII63214.1 - 0.026 14.6 0.1 0.085 13.0 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2833) TFIID_90kDa PF04494.10 KII63215.1 - 1.8e-10 41.0 1.3 2.5e-10 40.5 0.9 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit Fmp27_WPPW PF10359.4 KII63215.1 - 0.044 12.1 0.4 0.045 12.1 0.3 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Tubulin PF00091.20 KII63216.1 - 4.5e-70 235.8 0.0 6.6e-70 235.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KII63216.1 - 7.6e-46 155.2 0.6 1.2e-45 154.6 0.4 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 KII63216.1 - 4.1e-05 23.6 0.0 0.00027 20.9 0.0 2.2 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain DUF4264 PF14084.1 KII63216.1 - 0.22 10.9 1.3 0.48 9.8 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) RED_C PF07807.6 KII63217.1 - 4.7e-10 39.6 3.1 8.9e-10 38.7 2.1 1.4 1 0 0 1 1 1 1 RED-like protein C-terminal region FoP_duplication PF13865.1 KII63217.1 - 2.6 8.5 7.6 0.5 10.8 0.5 2.4 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 PTPLA PF04387.9 KII63218.1 - 3.4e-19 68.8 7.3 3.4e-19 68.8 5.1 1.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA DDE_3 PF13358.1 KII63219.1 - 0.00031 20.5 0.0 0.0009 19.0 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease Arm PF00514.18 KII63219.1 - 0.037 13.8 0.1 0.062 13.1 0.1 1.4 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat Toxin_35 PF10530.4 KII63219.1 - 8.6 6.5 9.1 4.6 7.4 0.1 2.7 3 0 0 3 3 3 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold LMBR1 PF04791.11 KII63222.1 - 1.5e-36 125.9 32.0 1.1e-22 80.2 9.6 2.0 2 0 0 2 2 2 2 LMBR1-like membrane protein Phage_Gp23 PF10669.4 KII63222.1 - 1 9.4 7.2 0.53 10.3 0.2 3.3 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) Sulfatase PF00884.18 KII63223.1 - 9.1e-11 41.4 0.0 8.9e-10 38.2 0.0 2.2 2 0 0 2 2 2 1 Sulfatase Sulfatase PF00884.18 KII63224.1 - 2.6e-29 102.4 0.5 3e-29 102.1 0.4 1.0 1 0 0 1 1 1 1 Sulfatase RRM_1 PF00076.17 KII63225.1 - 1.7e-38 130.1 0.0 9.5e-23 79.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII63225.1 - 7.8e-27 93.0 0.0 5.8e-12 45.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII63225.1 - 6.5e-20 70.7 0.0 7.7e-13 48.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII63225.1 - 0.00035 20.3 0.0 0.00091 19.0 0.0 1.7 1 0 0 1 1 1 1 RNA binding motif MIP-T3 PF10243.4 KII63225.1 - 2.3 6.6 21.9 3.1 6.1 15.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Maf1 PF09174.5 KII63227.1 - 7.5e-11 42.1 1.2 6.8e-09 35.8 0.6 2.1 2 0 0 2 2 2 2 Maf1 regulator Sas10_Utp3 PF04000.10 KII63228.1 - 3.3e-13 49.6 0.1 6.2e-13 48.7 0.1 1.4 1 0 0 1 1 1 1 Sas10/Utp3/C1D family OAS1_C PF10421.4 KII63228.1 - 0.089 12.2 0.1 0.11 11.9 0.1 1.3 1 1 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Peptidase_M41 PF01434.13 KII63229.1 - 5.8e-64 215.4 0.2 8.4e-64 214.9 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 KII63229.1 - 2.6e-22 79.4 0.0 9.2e-22 77.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RPN7 PF10602.4 KII63229.1 - 0.028 13.8 0.8 0.046 13.1 0.6 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 DDE_3 PF13358.1 KII63231.1 - 6e-10 39.0 0.0 7.4e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease TPR_11 PF13414.1 KII63232.1 - 0.0011 18.5 1.3 0.0031 17.1 0.9 1.7 1 0 0 1 1 1 1 TPR repeat TPR_8 PF13181.1 KII63232.1 - 0.0046 16.6 1.1 0.62 9.9 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KII63232.1 - 0.0056 16.5 0.6 0.028 14.3 0.7 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII63232.1 - 0.04 13.8 1.5 3.9 7.6 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.7 KII63232.1 - 0.12 12.9 2.6 6.5 7.5 0.1 2.8 3 0 0 3 3 3 0 Sel1 repeat TPR_1 PF00515.23 KII63232.1 - 0.23 11.1 2.7 1.9 8.2 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Ins134_P3_kin PF05770.6 KII63233.1 - 4e-35 121.3 2.6 4.6e-35 121.1 1.8 1.0 1 0 0 1 1 1 1 Inositol 1, 3, 4-trisphosphate 5/6-kinase RepA_N PF06970.6 KII63233.1 - 6.3 6.6 11.4 1.2 8.9 0.7 3.2 3 0 0 3 3 3 0 Replication initiator protein A (RepA) N-terminus Orn_DAP_Arg_deC PF00278.17 KII63234.1 - 0.15 11.7 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AhpC-TSA_2 PF13911.1 KII63235.1 - 1.8e-15 56.8 0.0 2.1e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme ThiF PF00899.16 KII63236.1 - 2.1e-39 134.4 0.0 6.5e-39 132.8 0.0 1.8 2 0 0 2 2 2 1 ThiF family UBACT PF02134.16 KII63236.1 - 2.5e-25 87.8 3.0 2.5e-25 87.8 2.1 2.2 3 0 0 3 3 3 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 KII63236.1 - 9.4e-19 66.5 0.2 2.2e-18 65.3 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.1 KII63236.1 - 6.4e-08 32.5 0.0 5.5e-07 29.6 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain NAD_binding_7 PF13241.1 KII63236.1 - 6.7e-06 26.2 0.0 1.6e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding MoeZ_MoeB PF05237.8 KII63236.1 - 0.00072 19.1 0.4 0.021 14.4 0.0 2.4 2 0 0 2 2 2 1 MoeZ/MoeB domain Shikimate_DH PF01488.15 KII63236.1 - 0.00072 19.6 0.1 0.0024 17.9 0.0 1.9 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Saccharop_dh PF03435.13 KII63236.1 - 0.0011 17.9 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase Pyr_redox PF00070.22 KII63236.1 - 0.033 14.6 0.1 0.073 13.4 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 KII63236.1 - 0.038 13.4 0.0 0.066 12.6 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DAO PF01266.19 KII63236.1 - 0.07 12.0 0.0 0.098 11.5 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase DDE_3 PF13358.1 KII63238.1 - 9.3e-18 64.3 0.0 1.3e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3048 PF11258.3 KII63238.1 - 0.0034 16.5 0.0 0.0051 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3048) HTH_Tnp_Tc3_2 PF01498.13 KII63238.1 - 0.0064 16.5 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 Transposase DUF1900 PF08954.6 KII63238.1 - 0.01 15.3 1.0 2.6 7.5 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1900) DUF3388 PF11868.3 KII63239.1 - 0.069 12.2 0.6 0.11 11.5 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3388) RVT_1 PF00078.22 KII63243.1 - 1.9e-25 89.5 0.2 7.1e-25 87.6 0.3 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII63243.1 - 1.8e-22 79.7 0.0 3.9e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII63243.1 - 4e-08 33.1 0.0 6.5e-07 29.2 0.0 2.4 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII63243.1 - 4.4e-05 23.2 3.2 0.00011 21.8 2.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII63243.1 - 0.00018 21.9 0.1 0.0011 19.4 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease rve_3 PF13683.1 KII63243.1 - 0.0035 16.8 0.1 0.052 13.0 0.0 3.0 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.9 KII63243.1 - 0.017 15.0 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII63243.1 - 0.03 14.1 0.0 0.075 12.8 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII63243.1 - 0.12 11.9 0.1 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease PAP2_C PF14360.1 KII63244.1 - 6.9e-08 32.6 16.0 7.6e-05 22.9 0.2 2.9 3 0 0 3 3 3 2 PAP2 superfamily C-terminal PAP2 PF01569.16 KII63244.1 - 0.0018 17.9 3.1 0.19 11.3 0.2 2.4 2 0 0 2 2 2 2 PAP2 superfamily PAP2_3 PF14378.1 KII63244.1 - 4.3 6.8 6.9 11 5.4 4.8 2.0 1 1 0 1 1 1 0 PAP2 superfamily Rho_GDI PF02115.12 KII63245.1 - 1.4e-26 93.1 0.2 1.9e-26 92.7 0.2 1.2 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos_2 PF12850.2 KII63246.1 - 2.3e-19 69.7 0.0 2.9e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KII63246.1 - 0.014 14.7 0.1 0.13 11.6 0.0 2.1 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase DDE_1 PF03184.14 KII63248.1 - 1.4e-07 30.8 0.0 2.2e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Exo_endo_phos PF03372.18 KII63249.1 - 3.6e-05 23.8 0.0 4.9e-05 23.3 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KII63249.1 - 0.022 14.3 0.2 0.1 12.1 0.0 2.1 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase Longin PF13774.1 KII63249.1 - 0.068 12.7 0.2 5.8 6.5 0.0 2.9 2 1 1 3 3 3 0 Regulated-SNARE-like domain Aminotran_3 PF00202.16 KII63250.1 - 1.4e-85 287.1 0.0 1.6e-85 286.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Annexin PF00191.15 KII63251.1 - 9.3e-06 25.4 0.1 1.3e-05 25.0 0.1 1.2 1 0 0 1 1 1 1 Annexin Serpin PF00079.15 KII63252.1 - 5.9e-44 150.7 3.1 8e-44 150.2 2.2 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RRM_1 PF00076.17 KII63255.1 - 1.2e-26 92.1 1.0 5.5e-21 73.9 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII63255.1 - 5.2e-22 77.5 0.1 5e-17 61.6 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII63255.1 - 4.4e-12 45.6 0.0 6.6e-09 35.4 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII63255.1 - 0.098 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ribosomal_L34e PF01199.13 KII63257.1 - 8.2e-41 138.1 5.5 9.5e-41 137.9 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L34e Laminin_EGF PF00053.19 KII63257.1 - 0.076 12.9 0.4 2.3 8.1 0.0 2.1 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) Fer2_BFD PF04324.10 KII63257.1 - 0.097 12.7 0.6 1.5 8.9 0.1 2.1 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain Dus PF01207.12 KII63258.1 - 1.4e-48 165.3 0.0 1.7e-48 165.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF4181 PF13789.1 KII63259.1 - 0.075 12.9 1.3 0.099 12.5 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) Ribonuclease_3 PF00636.21 KII63260.1 - 1.1e-32 112.8 0.0 5.1e-20 72.0 0.0 3.5 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 KII63260.1 - 2.4e-18 66.3 4.3 2.5e-08 33.9 0.3 3.9 5 0 0 5 5 5 2 Ribonuclease-III-like Dicer_dimer PF03368.9 KII63260.1 - 1.2e-15 57.0 0.1 3.3e-15 55.6 0.0 1.9 1 0 0 1 1 1 1 Dicer dimerisation domain dsrm PF00035.20 KII63260.1 - 8.4e-15 55.1 1.1 1.1e-05 25.8 0.0 3.8 3 0 0 3 3 3 3 Double-stranded RNA binding motif DEAD PF00270.24 KII63260.1 - 1.4e-11 44.1 0.0 3.2e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII63260.1 - 1.9e-11 43.6 0.1 6.5e-11 41.9 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII63260.1 - 1.4e-08 34.7 0.0 7.1e-08 32.4 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2017 PF09438.5 KII63260.1 - 0.46 10.0 0.0 0.88 9.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2017) DEAD PF00270.24 KII63262.1 - 1.6e-44 151.3 0.2 3.5e-44 150.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII63262.1 - 4.5e-21 74.5 0.1 1.7e-20 72.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII63262.1 - 2.4e-05 24.2 0.0 7.7e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KII63262.1 - 0.00027 19.8 0.0 0.00048 19.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Flavi_DEAD PF07652.9 KII63262.1 - 0.00053 19.7 0.1 0.72 9.5 0.0 2.7 2 0 0 2 2 2 2 Flavivirus DEAD domain AAA_22 PF13401.1 KII63262.1 - 0.016 15.3 0.0 0.051 13.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain UvrD-helicase PF00580.16 KII63262.1 - 0.026 13.8 0.1 0.057 12.7 0.0 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.1 KII63262.1 - 0.04 13.6 0.0 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 Part of AAA domain CMS1 PF14617.1 KII63262.1 - 0.054 12.5 0.0 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit UQ_con PF00179.21 KII63263.1 - 5.1e-42 142.6 0.1 5.9e-42 142.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KII63263.1 - 0.01 15.5 0.0 0.03 14.0 0.0 1.6 1 1 0 2 2 2 0 Prokaryotic E2 family B rve PF00665.21 KII63264.1 - 1.9e-25 89.3 0.0 3.4e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII63264.1 - 0.003 17.0 0.0 0.01 15.3 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Myosin_tail_1 PF01576.14 KII63265.1 - 7.7e-95 318.3 150.9 1.4e-88 297.6 90.2 2.0 1 1 1 2 2 2 2 Myosin tail IncA PF04156.9 KII63265.1 - 0.00017 21.2 23.8 0.00017 21.2 16.5 6.9 1 1 5 6 6 6 2 IncA protein GAS PF13851.1 KII63265.1 - 0.00026 20.2 39.4 0.00026 20.2 27.3 5.7 1 1 4 5 5 4 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 KII63265.1 - 0.00028 20.7 152.9 0.051 13.4 17.4 6.2 1 1 5 6 6 6 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.1 KII63265.1 - 0.0013 17.3 37.3 0.0013 17.3 25.9 3.1 1 1 1 3 3 3 3 AAA domain DUF4140 PF13600.1 KII63265.1 - 0.0036 17.7 7.5 0.0036 17.7 5.2 10.3 1 1 7 8 8 7 1 N-terminal domain of unknown function (DUF4140) Filament PF00038.16 KII63265.1 - 0.02 14.3 122.2 0.52 9.7 17.2 4.9 1 1 1 3 3 3 0 Intermediate filament protein Tropomyosin PF00261.15 KII63265.1 - 0.064 12.3 144.4 0.06 12.4 22.6 5.0 1 1 4 5 5 5 0 Tropomyosin Reo_sigmaC PF04582.7 KII63265.1 - 2.2 7.3 52.8 0.086 12.0 4.7 5.7 1 1 5 6 6 6 0 Reovirus sigma C capsid protein PPE PF00823.14 KII63265.1 - 4 7.2 9.6 0.28 11.0 1.2 3.1 3 0 0 3 3 3 0 PPE family Cortex-I_coil PF09304.5 KII63265.1 - 5.5 7.0 135.7 0.28 11.2 14.2 9.0 1 1 10 11 11 11 0 Cortexillin I, coiled coil Myosin_head PF00063.16 KII63266.1 - 1e-265 883.1 8.5 1e-265 883.1 5.9 1.8 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.14 KII63266.1 - 1.4e-11 43.8 0.0 3.6e-11 42.5 0.0 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_13 PF13166.1 KII63266.1 - 0.0015 17.1 19.1 0.0015 17.1 13.3 2.4 1 1 1 2 2 2 1 AAA domain Reo_sigmaC PF04582.7 KII63266.1 - 0.0057 15.8 9.5 0.0057 15.8 6.6 2.2 1 1 1 2 2 2 1 Reovirus sigma C capsid protein AAA_22 PF13401.1 KII63266.1 - 0.021 14.9 1.9 0.04 14.0 0.1 2.5 2 1 0 2 2 2 0 AAA domain HrpB7 PF09486.5 KII63266.1 - 0.13 12.2 22.9 0.95 9.3 9.0 2.5 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) PspA_IM30 PF04012.7 KII63266.1 - 0.15 11.4 42.2 0.47 9.7 5.5 2.9 1 1 1 2 2 2 0 PspA/IM30 family IncA PF04156.9 KII63266.1 - 0.29 10.6 42.3 1.5 8.4 7.6 2.6 1 1 1 2 2 2 0 IncA protein Cast PF10174.4 KII63266.1 - 0.33 8.9 45.5 0.57 8.1 31.5 1.3 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Laminin_II PF06009.7 KII63266.1 - 0.44 10.3 35.5 1.5 8.5 2.3 3.8 1 1 2 3 3 3 0 Laminin Domain II AAA_16 PF13191.1 KII63266.1 - 0.63 9.9 0.0 0.63 9.9 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain ADIP PF11559.3 KII63266.1 - 1.5 8.7 40.7 0.12 12.2 6.8 3.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.6 KII63266.1 - 3.1 6.3 46.8 0.014 14.0 6.1 2.9 2 1 1 3 3 3 0 Spc7 kinetochore protein HAP1_N PF04849.8 KII63266.1 - 3.5 6.5 41.7 0.089 11.7 11.6 2.7 1 1 1 2 2 2 0 HAP1 N-terminal conserved region SWI-SNF_Ssr4 PF08549.5 KII63266.1 - 4.8 5.3 15.2 7.2 4.7 10.5 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Spectrin PF00435.16 KII63266.1 - 5.4 7.3 32.8 0.069 13.4 7.0 3.3 1 1 1 2 2 2 0 Spectrin repeat CENP-F_leu_zip PF10473.4 KII63266.1 - 6.7 6.5 49.7 2.9 7.7 22.7 3.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lebercilin PF15619.1 KII63266.1 - 9.4 5.6 46.5 5.8 6.2 19.1 2.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease V_ATPase_I PF01496.14 KII63266.1 - 9.4 3.9 34.0 2.9 5.6 14.5 2.3 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family ORC5_C PF14630.1 KII63267.1 - 1.2e-28 100.3 0.7 1.6e-28 99.9 0.5 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus zf-CCHC PF00098.18 KII63268.1 - 8.9e-06 25.3 2.1 1.4e-05 24.8 1.4 1.3 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.1 KII63268.1 - 0.0024 17.6 0.1 0.0038 17.0 0.1 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII63268.1 - 0.042 13.7 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII63268.1 - 0.16 12.4 0.6 0.35 11.3 0.2 1.7 2 0 0 2 2 2 0 Aspartyl protease zf-CCHC_4 PF14392.1 KII63268.1 - 0.21 11.3 4.2 0.14 11.8 1.4 1.8 2 0 0 2 2 2 0 Zinc knuckle UQ_con PF00179.21 KII63270.1 - 6.2e-25 87.2 0.0 7.1e-25 87.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KII63270.1 - 0.00014 21.6 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain zf-CCHC PF00098.18 KII63273.1 - 2.6e-07 30.2 7.4 4.1e-05 23.2 1.0 4.1 5 0 0 5 5 5 2 Zinc knuckle zf-CCCH PF00642.19 KII63273.1 - 0.00011 21.8 3.4 0.00011 21.8 2.4 4.5 4 0 0 4 4 4 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCHC_2 PF13696.1 KII63273.1 - 0.035 13.6 1.2 0.2 11.2 0.2 3.6 4 0 0 4 4 4 0 Zinc knuckle eIF3g PF12353.3 KII63273.1 - 0.051 13.4 7.1 1.1 9.2 0.4 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_3 PF13917.1 KII63273.1 - 0.089 12.5 1.3 2.2 8.0 0.1 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCCH_2 PF14608.1 KII63273.1 - 0.12 12.4 22.9 0.2 11.7 0.8 5.0 5 0 0 5 5 5 0 Zinc finger C-x8-C-x5-C-x3-H type DUF2443 PF10398.4 KII63274.1 - 0.0067 16.2 0.8 0.013 15.2 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2443) IncA PF04156.9 KII63274.1 - 0.073 12.6 2.1 0.11 12.0 1.5 1.4 1 0 0 1 1 1 0 IncA protein ALMT PF11744.3 KII63274.1 - 0.12 10.9 2.0 0.14 10.7 1.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CesA PF11439.3 KII63274.1 - 0.25 11.2 3.7 1.3 8.9 2.6 2.0 1 1 0 1 1 1 0 Type III secretion system filament chaperone CesA Fzo_mitofusin PF04799.8 KII63274.1 - 0.59 9.4 3.7 0.72 9.2 0.0 2.1 2 1 0 2 2 2 0 fzo-like conserved region DUF4064 PF13273.1 KII63275.1 - 0.074 13.1 1.0 0.14 12.2 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) RVT_1 PF00078.22 KII63276.1 - 4.6e-21 75.1 0.1 1.1e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII63276.1 - 2e-08 34.0 0.0 4.6e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII63276.1 - 2.4e-05 24.0 11.8 0.0025 17.6 1.9 2.5 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII63276.1 - 0.00023 21.5 0.0 0.00059 20.2 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII63276.1 - 0.00039 19.9 0.1 0.0014 18.2 0.1 2.0 1 1 0 1 1 1 1 Aspartyl protease zf-CCHC_3 PF13917.1 KII63276.1 - 0.0027 17.4 5.8 0.015 14.9 0.3 2.5 1 1 1 2 2 2 2 Zinc knuckle Zn_Tnp_IS91 PF14319.1 KII63276.1 - 0.015 14.7 2.8 0.046 13.2 1.9 1.8 1 0 0 1 1 1 0 Transposase zinc-binding domain Herpes_UL14 PF03580.9 KII63276.1 - 0.02 14.6 0.1 0.054 13.2 0.0 1.7 1 0 0 1 1 1 0 Herpesvirus UL14-like protein gag-asp_proteas PF13975.1 KII63276.1 - 0.022 14.5 0.0 0.078 12.8 0.0 1.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Peptidase_A2B PF12384.3 KII63276.1 - 0.029 13.7 0.1 0.18 11.0 0.0 2.1 1 1 1 2 2 2 0 Ty3 transposon peptidase Spuma_A9PTase PF03539.9 KII63276.1 - 0.034 14.0 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP_2 PF08284.6 KII63276.1 - 0.037 13.9 0.1 0.067 13.1 0.1 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-ribbon_3 PF13248.1 KII63276.1 - 0.087 12.0 4.0 0.18 11.0 2.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-CCHC_5 PF14787.1 KII63276.1 - 0.31 10.5 10.5 0.18 11.2 0.8 2.7 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 KII63276.1 - 0.35 10.5 9.8 0.16 11.6 0.6 3.1 3 0 0 3 3 3 0 Zinc knuckle DUF1700 PF08006.6 KII63277.1 - 0.64 9.2 4.9 1.1 8.5 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) CoA_binding_3 PF13727.1 KII63277.1 - 3.3 7.4 10.7 1.1 9.0 4.8 2.0 2 1 0 2 2 2 0 CoA-binding domain Flavi_M PF01004.14 KII63278.1 - 0.13 11.7 0.0 0.62 9.5 0.0 2.0 2 0 0 2 2 2 0 Flavivirus envelope glycoprotein M Lectin_C PF00059.16 KII63279.1 - 2.9e-16 60.0 2.0 7.6e-16 58.6 1.4 1.8 1 0 0 1 1 1 1 Lectin C-type domain F5_F8_type_C PF00754.20 KII63279.1 - 2.1e-05 24.3 0.4 0.00011 22.0 0.0 2.1 2 0 0 2 2 2 1 F5/8 type C domain Herpes_UL45 PF05473.7 KII63279.1 - 0.0042 16.5 0.1 0.0084 15.5 0.1 1.5 1 1 0 1 1 1 1 UL45 protein ShK PF01549.19 KII63279.1 - 4.6 7.6 10.6 4.8 7.6 4.1 2.5 2 0 0 2 2 2 0 ShK domain-like SNAP PF14938.1 KII63280.1 - 3.1e-06 26.5 2.7 3.7e-06 26.2 1.9 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.1 KII63280.1 - 0.0045 16.6 5.6 0.48 10.3 0.0 4.2 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF217 PF02697.9 KII63280.1 - 0.086 13.1 0.9 0.14 12.4 0.6 1.5 1 1 0 1 1 1 0 Uncharacterized ACR, COG1753 TPR_12 PF13424.1 KII63280.1 - 0.097 12.6 4.8 3.7 7.5 0.0 3.1 1 1 1 3 3 3 0 Tetratricopeptide repeat CLU_N PF15044.1 KII63281.1 - 0.082 13.0 0.0 6.1 7.0 0.0 2.7 1 1 2 3 3 3 0 Mitochondrial function, CLU-N-term Tyr_Deacylase PF02580.11 KII63282.1 - 6.3e-18 65.1 0.1 7e-18 65.0 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase ERAP1_C PF11838.3 KII63283.1 - 1.9e-17 63.5 0.0 2.2e-17 63.3 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain ASFV_360 PF01671.11 KII63283.1 - 0.025 13.9 0.7 0.033 13.5 0.5 1.2 1 0 0 1 1 1 0 African swine fever virus multigene family 360 protein Peptidase_M1 PF01433.15 KII63284.1 - 0.0037 16.3 0.1 0.0043 16.2 0.1 1.0 1 0 0 1 1 1 1 Peptidase family M1 DUF1053 PF06327.9 KII63284.1 - 0.1 12.9 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) Peptidase_M1 PF01433.15 KII63285.1 - 7.5e-74 249.1 0.8 8.9e-74 248.8 0.6 1.0 1 0 0 1 1 1 1 Peptidase family M1 DUF1401 PF07180.6 KII63285.1 - 0.12 12.1 0.2 0.28 10.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1401) ERAP1_C PF11838.3 KII63286.1 - 3.6e-05 23.1 0.0 4e-05 23.0 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain DUF3130 PF11328.3 KII63286.1 - 0.028 14.4 0.0 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3130 DUF3922 PF13059.1 KII63286.1 - 0.088 13.0 0.1 0.18 11.9 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3992) DASH_Duo1 PF08651.5 KII63289.1 - 0.007 15.9 0.1 0.026 14.1 0.0 1.9 2 0 0 2 2 2 1 DASH complex subunit Duo1 DUF682 PF05081.7 KII63289.1 - 0.12 11.9 3.7 0.2 11.1 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF682) PRANC PF09372.5 KII63289.1 - 0.65 9.9 7.5 0.097 12.6 0.4 2.5 2 1 1 3 3 3 0 PRANC domain rve PF00665.21 KII63290.1 - 0.0001 22.4 0.1 0.00024 21.1 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain Peptidase_M30 PF10460.4 KII63292.1 - 0.071 11.9 0.0 0.098 11.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase M30 CENP-B_dimeris PF09026.5 KII63292.1 - 1.1 9.5 9.4 2 8.7 6.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain 7tm_1 PF00001.16 KII63293.1 - 4.4e-14 52.2 17.6 5.5e-14 51.9 12.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DDE_3 PF13358.1 KII63296.1 - 1.2e-28 99.7 0.0 1.7e-28 99.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII63296.1 - 0.00032 20.6 0.1 0.0017 18.3 0.0 2.0 2 0 0 2 2 2 1 Transposase rve PF00665.21 KII63296.1 - 0.0019 18.2 0.1 0.0029 17.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HTH_33 PF13592.1 KII63296.1 - 0.016 14.7 0.0 0.041 13.4 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix HTH_28 PF13518.1 KII63296.1 - 0.037 14.0 0.1 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_29 PF13551.1 KII63296.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix SNAP PF14938.1 KII63297.1 - 5.9e-09 35.4 1.2 6.9e-09 35.2 0.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Apc3 PF12895.2 KII63297.1 - 0.013 15.6 1.0 0.024 14.7 0.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KII63297.1 - 0.014 15.7 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII63297.1 - 0.039 13.5 0.1 0.078 12.6 0.1 1.6 1 1 0 1 1 1 0 TPR repeat DUF1717 PF05414.6 KII63297.1 - 0.061 13.7 0.1 0.097 13.1 0.1 1.4 1 0 0 1 1 1 0 Viral domain of unknown function (DUF1717) TPR_12 PF13424.1 KII63297.1 - 0.07 13.0 0.1 0.34 10.8 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII63297.1 - 0.073 13.0 0.0 0.29 11.1 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.1 KII63297.1 - 0.082 11.9 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat PRANC PF09372.5 KII63300.1 - 0.21 11.5 3.2 0.88 9.5 1.1 2.0 1 1 1 2 2 2 0 PRANC domain DUF4524 PF15025.1 KII63302.1 - 0.056 12.9 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4524) Fumarate_red_C PF02300.12 KII63303.1 - 0.043 13.6 0.0 0.06 13.2 0.0 1.2 1 0 0 1 1 1 0 Fumarate reductase subunit C SNAP PF14938.1 KII63305.1 - 0.0032 16.6 2.6 0.0032 16.6 1.8 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP NSF PF02071.15 KII63305.1 - 0.4 11.4 10.9 21 6.2 0.3 4.8 4 1 1 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat DUF4371 PF14291.1 KII63306.1 - 0.0024 17.4 0.1 0.0037 16.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) SNAP PF14938.1 KII63307.1 - 4.5e-08 32.5 0.5 8.1e-08 31.7 0.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP rve PF00665.21 KII63307.1 - 0.028 14.5 0.2 0.24 11.5 0.0 2.3 2 0 0 2 2 2 0 Integrase core domain TPR_8 PF13181.1 KII63307.1 - 0.05 13.4 5.7 0.69 9.8 0.1 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat PurA PF04845.8 KII63309.1 - 1e-15 57.4 0.4 1.4e-11 43.9 0.1 2.3 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein RRXRR PF14239.1 KII63309.1 - 0.023 14.1 1.1 0.045 13.1 0.7 1.5 1 0 0 1 1 1 0 RRXRR protein Ribosomal_S25 PF03297.10 KII63312.1 - 4.9e-25 87.6 13.5 1.6e-24 85.9 9.4 1.7 1 1 0 1 1 1 1 S25 ribosomal protein MarR_2 PF12802.2 KII63312.1 - 0.12 12.0 0.0 6.8 6.4 0.0 2.2 2 0 0 2 2 2 0 MarR family SAND PF01342.16 KII63313.1 - 3.7e-25 87.4 0.3 7.5e-25 86.4 0.2 1.5 1 0 0 1 1 1 1 SAND domain zf-MYND PF01753.13 KII63313.1 - 1.7e-09 37.4 16.1 4e-09 36.1 11.2 1.7 1 0 0 1 1 1 1 MYND finger Pkinase PF00069.20 KII63314.1 - 1.9e-74 250.0 0.0 2.2e-74 249.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII63314.1 - 7.3e-32 110.4 0.0 9.2e-32 110.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII63314.1 - 0.00012 21.1 0.0 0.00025 20.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 KII63314.1 - 0.0029 17.3 0.0 0.0046 16.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KII63314.1 - 0.076 12.0 0.0 0.21 10.6 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Exo_endo_phos PF03372.18 KII63315.1 - 2e-26 93.4 0.9 2.4e-26 93.1 0.6 1.0 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KII63315.1 - 2.5e-14 52.9 0.2 3.7e-14 52.3 0.2 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase AA_permease_2 PF13520.1 KII63316.1 - 1.2e-44 152.5 58.2 1.4e-44 152.2 40.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII63316.1 - 7.2e-26 90.5 51.2 1.9e-25 89.1 35.5 1.5 1 1 0 1 1 1 1 Amino acid permease ALMT PF11744.3 KII63316.1 - 0.81 8.2 10.0 2 6.9 6.9 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF718 PF05336.8 KII63318.1 - 0.021 14.6 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF718) Cytochrome-c551 PF10643.4 KII63319.1 - 2.6 7.2 9.4 4.9 6.3 6.5 1.5 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 Daxx PF03344.10 KII63319.1 - 7.1 4.9 32.2 9 4.6 22.3 1.1 1 0 0 1 1 1 0 Daxx Family Leu_Phe_trans PF03588.9 KII63321.1 - 0.0042 16.2 0.0 0.0089 15.1 0.0 1.5 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase DUF4045 PF13254.1 KII63322.1 - 0.97 8.6 9.0 1.2 8.3 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Serglycin PF04360.7 KII63323.1 - 0.063 13.0 0.9 0.089 12.5 0.6 1.2 1 0 0 1 1 1 0 Serglycin Hid1 PF12722.2 KII63323.1 - 0.51 7.9 16.2 0.61 7.6 11.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UPF0239 PF06783.6 KII63323.1 - 0.59 10.0 3.4 0.34 10.8 0.4 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Daxx PF03344.10 KII63323.1 - 5.4 5.3 22.7 6.4 5.1 15.7 1.0 1 0 0 1 1 1 0 Daxx Family Macoilin PF09726.4 KII63323.1 - 6.9 4.8 12.6 9.9 4.2 8.7 1.2 1 0 0 1 1 1 0 Transmembrane protein UAA PF08449.6 KII63324.1 - 2.5e-30 105.4 29.9 3.2e-30 105.1 20.7 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KII63324.1 - 1.7e-05 24.5 11.4 1.7e-05 24.5 7.9 2.9 1 1 1 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KII63324.1 - 0.00088 19.3 12.9 0.00088 19.3 8.9 2.7 2 1 1 3 3 3 1 EamA-like transporter family Ribosomal_L7Ae PF01248.21 KII63326.1 - 3.9e-08 32.7 0.1 5.9e-08 32.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 KII63326.1 - 4.3e-05 23.3 0.1 5.1e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 PP1 PF07430.6 KII63326.1 - 0.035 13.6 0.9 0.045 13.3 0.6 1.3 1 0 0 1 1 1 0 Phloem filament protein PP1 Sec7 PF01369.15 KII63327.1 - 1.1e-59 201.2 3.8 1.1e-59 201.2 2.6 2.8 2 0 0 2 2 2 1 Sec7 domain DUF1981 PF09324.5 KII63327.1 - 2e-19 68.8 2.1 2e-19 68.8 1.5 5.0 3 1 1 4 4 4 1 Domain of unknown function (DUF1981) Sec7_N PF12783.2 KII63327.1 - 6.7e-18 64.6 15.2 6.7e-18 64.6 10.6 3.3 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Ipi1_N PF12333.3 KII63327.1 - 0.018 15.0 1.8 0.66 9.9 0.0 4.1 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation DUF2101 PF09874.4 KII63332.1 - 0.048 13.1 0.4 0.075 12.5 0.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) DnaB_2 PF07261.6 KII63333.1 - 0.025 14.1 0.0 0.051 13.1 0.0 1.6 1 0 0 1 1 1 0 Replication initiation and membrane attachment VHP PF02209.14 KII63334.1 - 0.38 10.4 2.4 0.31 10.7 0.1 2.0 2 0 0 2 2 2 0 Villin headpiece domain Mononeg_RNA_pol PF00946.14 KII63336.1 - 0.092 10.1 0.0 0.12 9.7 0.0 1.0 1 0 0 1 1 1 0 Mononegavirales RNA dependent RNA polymerase SRP72 PF08492.7 KII63337.1 - 2.3e-13 50.2 7.4 1.1e-12 48.0 5.1 2.2 1 0 0 1 1 1 1 SRP72 RNA-binding domain Fis1_TPR_C PF14853.1 KII63337.1 - 0.067 13.0 0.5 6.6 6.7 0.0 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat NPP PF08384.5 KII63340.1 - 0.0097 15.5 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region DUF1489 PF07370.6 KII63340.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) LNS2 PF08235.8 KII63340.1 - 0.12 11.9 0.1 0.33 10.5 0.1 1.7 1 1 1 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) Ras PF00071.17 KII63341.1 - 7.6e-10 38.4 0.1 1.2e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Ras family MobB PF03205.9 KII63342.1 - 0.00043 20.0 0.2 0.00093 18.9 0.2 1.7 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 KII63342.1 - 0.0005 20.5 0.0 0.00063 20.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein DUF815 PF05673.8 KII63342.1 - 0.0026 16.7 0.0 0.0031 16.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Septin PF00735.13 KII63342.1 - 0.0033 16.4 0.0 0.0044 16.0 0.0 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 KII63342.1 - 0.011 15.7 0.0 0.013 15.4 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Arch_ATPase PF01637.13 KII63342.1 - 0.016 14.9 0.1 0.02 14.6 0.1 1.1 1 0 0 1 1 1 0 Archaeal ATPase AAA_14 PF13173.1 KII63342.1 - 0.024 14.5 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KII63342.1 - 0.033 14.3 0.0 0.048 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KII63342.1 - 0.042 13.3 0.1 0.09 12.3 0.1 1.6 1 1 0 1 1 1 0 P-loop containing region of AAA domain KaiC PF06745.8 KII63342.1 - 0.051 12.6 0.1 0.071 12.2 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.1 KII63342.1 - 0.051 12.9 0.0 0.058 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 KII63342.1 - 0.062 12.7 0.1 0.091 12.1 0.1 1.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Ras PF00071.17 KII63342.1 - 0.11 11.9 0.1 0.14 11.4 0.1 1.4 1 1 0 1 1 1 0 Ras family FtsK_SpoIIIE PF01580.13 KII63342.1 - 0.12 11.8 0.1 0.18 11.2 0.0 1.3 1 1 0 1 1 1 0 FtsK/SpoIIIE family ATP-synt_ab PF00006.20 KII63342.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain RuBisCO_large PF00016.15 KII63343.1 - 0.023 13.5 0.1 0.026 13.3 0.1 1.2 1 1 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, catalytic domain Toxin_64 PF15542.1 KII63343.1 - 0.1 13.1 2.5 0.96 10.0 0.3 2.2 1 1 1 2 2 2 0 Putative toxin 64 Bromodomain PF00439.20 KII63347.1 - 3.3e-14 52.5 2.8 3.7e-14 52.3 0.1 2.3 2 0 0 2 2 2 1 Bromodomain BLOC1_2 PF10046.4 KII63347.1 - 2 8.6 8.8 4.1 7.6 0.3 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FANCI_S4 PF14678.1 KII63348.1 - 2.5e-22 79.2 7.7 7.7e-22 77.6 2.2 2.0 2 0 0 2 2 2 2 FANCI solenoid 4 DDE_3 PF13358.1 KII63349.1 - 0.0055 16.4 0.0 0.0073 16.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease LRR19-TM PF15176.1 KII63351.1 - 0.0059 16.2 0.1 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain WH2 PF02205.15 KII63353.1 - 0.00025 20.5 0.1 0.0005 19.5 0.1 1.5 1 0 0 1 1 1 1 WH2 motif E3_UbLigase_R4 PF13764.1 KII63353.1 - 0.072 10.9 0.1 0.1 10.4 0.1 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 Mito_fiss_reg PF05308.6 KII63353.1 - 1 8.6 8.7 1.2 8.4 6.0 1.3 1 1 0 1 1 1 0 Mitochondrial fission regulator CDP-OH_P_transf PF01066.16 KII63355.1 - 7e-07 29.4 8.2 7e-07 29.4 5.7 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TPR_3 PF07720.7 KII63355.1 - 0.27 11.0 2.0 0.57 10.0 0.3 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Kelch_6 PF13964.1 KII63356.1 - 0.08 13.1 0.5 0.08 13.1 0.3 2.0 3 1 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 KII63357.1 - 4.4e-24 83.5 17.0 3.1e-05 23.9 0.2 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII63357.1 - 7.3e-20 70.4 27.6 7.3e-06 25.6 0.2 7.8 6 3 1 7 7 7 6 Galactose oxidase, central domain Kelch_1 PF01344.20 KII63357.1 - 1.1e-18 66.4 21.0 7.5e-06 25.3 0.2 6.8 6 1 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 KII63357.1 - 1.7e-14 53.4 21.5 0.0023 18.0 0.0 7.4 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII63357.1 - 6.8e-14 51.4 17.3 0.0017 18.2 0.2 6.7 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.10 KII63357.1 - 7.3e-08 31.8 13.5 3.2 7.6 0.7 6.6 6 1 0 6 6 6 4 Kelch motif Rax2 PF12768.2 KII63357.1 - 0.027 13.7 0.2 0.027 13.7 0.2 1.9 2 1 1 3 3 3 0 Cortical protein marker for cell polarity DUF1373 PF07117.6 KII63358.1 - 0.19 11.4 2.4 0.22 11.2 1.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1373) zf-UBR PF02207.15 KII63362.1 - 4.5e-08 32.7 16.7 1.3e-07 31.1 11.3 1.9 1 1 1 2 2 2 1 Putative zinc finger in N-recognin (UBR box) DDE_3 PF13358.1 KII63364.1 - 0.0029 17.3 0.1 0.05 13.3 0.0 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease Ribosomal_L12 PF00542.14 KII63367.1 - 1.2e-21 76.4 1.0 1.2e-21 76.4 0.7 1.7 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain DUF659 PF04937.10 KII63367.1 - 0.035 13.5 0.1 3.4 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) Herpes_LMP1 PF05297.6 KII63369.1 - 0.15 10.9 2.8 0.2 10.5 1.9 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) HCaRG PF07258.9 KII63370.1 - 6.7e-09 35.5 0.6 8.7e-09 35.1 0.4 1.2 1 0 0 1 1 1 1 HCaRG protein DUF3804 PF12707.2 KII63370.1 - 0.0067 16.0 0.4 0.27 10.8 0.0 2.6 1 1 2 3 3 3 1 Protein of unknown function (DUF3804) PfUIS3 PF11567.3 KII63370.1 - 0.06 13.5 0.1 0.13 12.4 0.0 1.6 1 1 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein FolB PF02152.13 KII63370.1 - 0.12 12.5 0.1 0.3 11.2 0.0 1.8 1 1 1 2 2 2 0 Dihydroneopterin aldolase ARPC4 PF05856.7 KII63371.1 - 2.1e-71 238.7 7.4 2.3e-71 238.6 5.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) DUF4547 PF15080.1 KII63371.1 - 0.00029 20.3 0.3 0.00032 20.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4547) LETM1 PF07766.8 KII63374.1 - 8.6e-06 24.9 0.9 1.3e-05 24.3 0.3 1.3 1 1 0 1 1 1 1 LETM1-like protein LETM1 PF07766.8 KII63375.1 - 3.6e-12 45.8 0.1 5.2e-12 45.3 0.1 1.3 1 0 0 1 1 1 1 LETM1-like protein Cut8_M PF14483.1 KII63375.1 - 0.0096 15.7 0.1 0.018 14.8 0.1 1.5 1 0 0 1 1 1 1 Cut8 dimerisation domain SAP PF02037.22 KII63375.1 - 0.018 14.5 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 SAP domain Ribosomal_L11 PF00298.14 KII63376.1 - 1.1e-16 60.7 0.0 1.7e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.9 KII63376.1 - 0.00068 19.0 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain DDE_Tnp_IS1595 PF12762.2 KII63377.1 - 1e-18 67.5 0.1 1.3e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain SLAIN PF15301.1 KII63378.1 - 0.025 13.7 0.5 0.029 13.5 0.3 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family Lon_2 PF13337.1 KII63379.1 - 0.016 13.5 0.3 0.026 12.9 0.0 1.4 2 0 0 2 2 2 0 Putative ATP-dependent Lon protease ArfGap PF01412.13 KII63381.1 - 1.6e-29 102.0 0.4 7.8e-29 99.8 0.3 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SNAP PF14938.1 KII63382.1 - 1.5e-11 43.9 4.5 3.2e-11 42.9 3.0 1.6 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Reprolysin_2 PF13574.1 KII63383.1 - 1.9e-12 47.5 0.9 4.5e-12 46.3 0.1 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 KII63383.1 - 4.2e-10 39.8 0.1 4.2e-10 39.8 0.1 2.3 2 0 0 2 2 2 1 Metallo-peptidase family M12 Disintegrin PF00200.18 KII63383.1 - 1.2e-08 34.9 22.5 1.2e-08 34.9 15.6 3.2 1 1 2 3 3 3 1 Disintegrin Reprolysin_4 PF13583.1 KII63383.1 - 1.4e-06 27.9 0.0 3.2e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 KII63383.1 - 1e-05 26.0 2.4 1.8e-05 25.2 0.0 2.4 3 0 0 3 3 3 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M56 PF05569.6 KII63383.1 - 0.063 12.2 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 HC2 PF07382.6 KII63385.1 - 3.6e-17 62.8 46.1 3.3e-09 36.9 15.3 2.0 1 1 1 2 2 2 2 Histone H1-like nucleoprotein HC2 PMG PF05287.7 KII63385.1 - 0.017 14.9 24.5 0.065 13.0 17.1 1.7 1 1 0 1 1 1 0 PMG protein Keratin_B2 PF01500.12 KII63385.1 - 2.8 7.7 50.4 1.3e+02 2.2 34.9 2.4 1 1 0 1 1 1 0 Keratin, high sulfur B2 protein RhoGAP PF00620.22 KII63386.1 - 2e-42 144.3 0.2 1.3e-41 141.7 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain DegS PF05384.6 KII63387.1 - 0.0064 15.7 2.1 0.009 15.2 1.4 1.2 1 0 0 1 1 1 1 Sensor protein DegS DUF1043 PF06295.7 KII63387.1 - 0.0083 15.7 3.9 0.011 15.3 2.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF3785 PF12653.2 KII63387.1 - 0.017 14.9 0.7 0.021 14.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3785) Med15_fungi PF05397.7 KII63387.1 - 0.027 14.4 0.6 0.061 13.2 0.2 1.8 1 1 0 1 1 1 0 Mediator complex subunit 15 ASL_C PF08328.6 KII63387.1 - 0.03 14.1 1.0 0.33 10.8 0.7 2.2 1 1 0 1 1 1 0 Adenylosuccinate lyase C-terminal AATF-Che1 PF13339.1 KII63387.1 - 0.039 14.0 4.6 0.055 13.6 3.2 1.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor V_ATPase_I PF01496.14 KII63387.1 - 0.14 9.9 5.9 0.15 9.8 4.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Toxin_52 PF15605.1 KII63387.1 - 0.2 11.5 0.2 0.2 11.5 0.1 2.0 1 1 1 2 2 2 0 Putative toxin 52 IncA PF04156.9 KII63387.1 - 0.78 9.3 5.6 0.9 9.1 3.9 1.2 1 0 0 1 1 1 0 IncA protein Ras PF00071.17 KII63388.1 - 7.6e-05 22.1 1.8 0.004 16.5 0.1 3.1 3 0 0 3 3 3 2 Ras family GTP_EFTU PF00009.22 KII63388.1 - 0.0013 18.1 0.3 0.0032 16.9 0.2 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SNAP PF14938.1 KII63391.1 - 9.2e-09 34.8 0.2 1.1e-08 34.5 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP HEPN PF05168.9 KII63391.1 - 0.088 12.6 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 HEPN domain VRP1 PF03538.9 KII63391.1 - 0.11 11.5 0.1 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Salmonella virulence plasmid 28.1kDa A protein zf-CCHC PF00098.18 KII63395.1 - 9.3e-06 25.3 12.3 0.017 15.0 4.2 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 KII63395.1 - 0.027 14.1 6.5 1.6 8.4 0.5 2.9 2 0 0 2 2 2 0 Zinc knuckle gag-asp_proteas PF13975.1 KII63395.1 - 0.074 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-TRAF PF02176.13 KII63395.1 - 0.99 9.8 6.1 0.6 10.5 0.8 2.8 3 1 1 4 4 4 0 TRAF-type zinc finger rve PF00665.21 KII63396.1 - 1.6e-21 76.6 0.1 2.3e-21 76.1 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII63396.1 - 5.2e-05 22.6 0.0 0.00012 21.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII63396.1 - 0.00014 21.5 0.1 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Nepo_coat_N PF03689.10 KII63396.1 - 0.011 15.4 0.1 0.094 12.4 0.0 2.3 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain DUF1796 PF08795.5 KII63396.1 - 0.057 13.0 0.1 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) SMC_N PF02463.14 KII63397.1 - 0.084 12.0 0.2 0.1 11.7 0.2 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.22 KII63397.1 - 0.087 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter ABC_membrane PF00664.18 KII63398.1 - 1.6e-41 142.5 53.4 5.4e-22 78.4 13.2 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 KII63398.1 - 1e-18 67.9 0.0 3.1e-18 66.4 0.0 1.9 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KII63398.1 - 3.5e-06 26.4 0.1 0.026 13.7 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KII63398.1 - 0.0004 20.7 0.6 0.0013 19.0 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII63398.1 - 0.018 15.1 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KII63398.1 - 0.074 12.7 0.0 0.25 10.9 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_29 PF13555.1 KII63398.1 - 0.094 12.2 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.18 KII63398.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Dynamin family T2SE PF00437.15 KII63398.1 - 0.11 11.4 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 KII63398.1 - 0.18 11.7 0.2 0.71 9.8 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Med6 PF04934.9 KII63400.1 - 5.4e-34 116.7 0.6 7.1e-34 116.3 0.4 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component Proteasome PF00227.21 KII63401.1 - 1e-47 161.9 0.1 1.3e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KII63401.1 - 1.3e-13 49.9 0.0 2.6e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF1394 PF07159.7 KII63401.1 - 0.0025 17.0 0.1 0.0046 16.1 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1394) vATP-synt_E PF01991.13 KII63402.1 - 1.7e-56 190.6 6.9 2e-56 190.4 4.8 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Chordopox_G2 PF05796.7 KII63402.1 - 0.022 13.8 2.9 0.63 9.1 1.7 2.4 1 1 0 2 2 2 0 Chordopoxvirus protein G2 C9orf72-like PF15019.1 KII63402.1 - 0.071 12.3 1.2 0.084 12.1 0.3 1.6 2 0 0 2 2 2 0 C9orf72-like protein family Suf PF05843.9 KII63404.1 - 2.8e-19 69.9 0.7 3.5e-19 69.6 0.2 1.3 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) Suf PF05843.9 KII63405.1 - 0.00039 20.2 0.0 0.00069 19.4 0.0 1.4 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DUF3395 PF11875.3 KII63405.1 - 0.026 14.1 0.1 0.026 14.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) CBM49 PF09478.5 KII63406.1 - 0.011 15.7 0.2 0.019 15.0 0.1 1.4 1 1 0 1 1 1 0 Carbohydrate binding domain CBM49 Ca_hom_mod PF14798.1 KII63407.1 - 0.021 13.7 0.0 0.039 12.9 0.0 1.4 1 0 0 1 1 1 0 Calcium homeostasis modulator NUDIX PF00293.23 KII63408.1 - 6.3e-09 35.5 0.0 1e-08 34.9 0.0 1.3 1 1 0 1 1 1 1 NUDIX domain SLS PF14611.1 KII63409.1 - 0.025 13.9 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator NUDIX PF00293.23 KII63410.1 - 1.8e-07 30.8 0.0 2.7e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DDE_3 PF13358.1 KII63411.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.4 1 1 0 1 1 1 0 DDE superfamily endonuclease Peptidase_C65 PF10275.4 KII63411.1 - 0.045 13.1 0.2 0.046 13.0 0.1 1.1 1 0 0 1 1 1 0 Peptidase C65 Otubain RhoGEF PF00621.15 KII63412.1 - 1.9e-12 47.4 11.0 1.9e-12 47.4 7.6 1.7 1 1 1 2 2 2 1 RhoGEF domain Bcl-2 PF00452.14 KII63412.1 - 0.052 13.6 0.1 0.17 12.0 0.0 1.9 2 1 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family Ras PF00071.17 KII63413.1 - 0.003 16.9 0.1 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 Ras family RelB PF04221.7 KII63413.1 - 0.058 13.1 0.2 0.98 9.2 0.1 2.1 2 0 0 2 2 2 0 RelB antitoxin Arf PF00025.16 KII63414.1 - 5.6e-63 211.3 0.0 6.6e-63 211.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KII63414.1 - 4.4e-16 58.7 0.0 5e-16 58.5 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 KII63414.1 - 4.5e-12 45.5 0.0 5.6e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 KII63414.1 - 3.5e-11 43.6 0.0 4.5e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 KII63414.1 - 2e-10 40.2 0.0 2.2e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 KII63414.1 - 4.3e-10 38.8 3.1 4.4e-08 32.2 1.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.18 KII63414.1 - 1.8e-07 31.1 0.0 2.4e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KII63414.1 - 2e-06 27.3 0.0 1.5e-05 24.4 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain 6PF2K PF01591.13 KII63414.1 - 0.0004 19.5 0.1 0.0085 15.1 0.0 2.0 2 0 0 2 2 2 1 6-phosphofructo-2-kinase AAA_18 PF13238.1 KII63414.1 - 0.072 13.3 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 KII63414.1 - 0.12 11.8 0.0 0.53 9.7 0.0 2.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CHCH PF06747.8 KII63416.1 - 1.6e-06 27.8 3.4 3.1e-06 26.9 2.3 1.5 1 0 0 1 1 1 1 CHCH domain GCK PF07802.6 KII63416.1 - 0.0069 16.4 1.6 0.0093 16.0 1.1 1.2 1 0 0 1 1 1 1 GCK domain DUF3595 PF12166.3 KII63417.1 - 7.3e-34 117.3 7.4 1.6e-33 116.1 5.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3595) AAA_21 PF13304.1 KII63419.1 - 0.0052 16.7 0.1 0.0064 16.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain DDE_1 PF03184.14 KII63419.1 - 0.017 14.3 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease RNA_pol_Rpb1_5 PF04998.12 KII63420.1 - 7.7e-93 310.7 0.0 5.6e-67 225.9 0.0 2.7 1 1 1 2 2 2 2 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 KII63420.1 - 1.6e-57 194.0 0.9 7e-57 191.9 0.6 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 KII63420.1 - 9.2e-33 113.2 0.0 4.8e-31 107.6 0.0 3.3 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 KII63420.1 - 2.4e-23 81.9 0.3 1.3e-22 79.6 0.2 2.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.7 KII63420.1 - 4.7e-21 75.4 2.3 4.7e-21 75.4 1.6 4.8 5 1 0 5 5 5 2 RNA polymerase Rpb1, domain 1 BUD22 PF09073.5 KII63420.1 - 0.0058 15.7 10.8 0.011 14.8 7.5 1.4 1 0 0 1 1 1 1 BUD22 CobT PF06213.7 KII63420.1 - 1.3 8.0 15.6 2.1 7.3 10.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.7 KII63420.1 - 6.2 5.9 14.3 12 4.9 9.9 1.4 1 0 0 1 1 1 0 NOA36 protein Mito_carr PF00153.22 KII63422.1 - 9.5e-41 137.4 0.0 6.6e-21 73.8 0.0 2.1 1 1 1 2 2 2 2 Mitochondrial carrier protein Antimicrobial20 PF08256.6 KII63422.1 - 0.013 15.6 0.5 0.21 12.0 0.0 3.1 3 0 0 3 3 3 0 Aurein-like antibiotic peptide Sugar_tr PF00083.19 KII63423.1 - 1.7e-10 40.0 10.1 6.6e-10 38.1 5.1 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter ATP_bind_1 PF03029.12 KII63424.1 - 1.4e-11 44.4 0.0 1.8e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Mer2 PF09074.5 KII63424.1 - 0.0013 18.7 0.7 0.0016 18.3 0.5 1.1 1 0 0 1 1 1 1 Mer2 RGM_N PF06535.7 KII63424.1 - 0.01 15.8 0.1 0.013 15.5 0.0 1.1 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) N-terminus FliD_C PF07195.7 KII63424.1 - 0.012 14.9 1.0 0.014 14.7 0.7 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF2718 PF10918.3 KII63424.1 - 0.068 13.2 0.3 0.073 13.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2718) ATP_bind_1 PF03029.12 KII63425.1 - 7.2e-27 94.4 0.1 1.1e-26 93.8 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein T2SE PF00437.15 KII63425.1 - 3.3e-05 22.9 0.0 3.7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA12 PF10443.4 KII63425.1 - 0.00025 19.6 0.0 0.00026 19.6 0.0 1.0 1 0 0 1 1 1 1 RNA12 protein NB-ARC PF00931.17 KII63425.1 - 0.0015 17.4 0.1 0.0019 17.1 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.1 KII63425.1 - 0.0028 17.6 0.0 0.0036 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 KII63425.1 - 0.0032 17.1 0.1 0.0043 16.7 0.0 1.2 1 0 0 1 1 1 1 Archaeal ATPase AAA_17 PF13207.1 KII63425.1 - 0.0047 17.7 0.6 0.01 16.6 0.4 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII63425.1 - 0.019 15.0 0.1 0.023 14.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KII63425.1 - 0.024 14.3 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 Part of AAA domain Trm56 PF01994.11 KII63425.1 - 0.026 14.2 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 Viral_helicase1 PF01443.13 KII63425.1 - 0.026 14.0 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.7 KII63425.1 - 0.032 13.8 0.1 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.1 KII63425.1 - 0.036 13.9 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 KII63425.1 - 0.041 13.5 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DUF87 PF01935.12 KII63425.1 - 0.045 13.5 0.7 0.061 13.1 0.5 1.3 1 1 0 1 1 1 0 Domain of unknown function DUF87 G-alpha PF00503.15 KII63425.1 - 0.05 12.2 0.1 0.068 11.8 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit MobB PF03205.9 KII63425.1 - 0.059 13.0 0.4 0.087 12.5 0.3 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 KII63425.1 - 0.063 12.8 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 KII63425.1 - 0.091 12.6 0.3 0.14 12.0 0.2 1.3 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KII63425.1 - 0.11 11.9 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain FtsK_SpoIIIE PF01580.13 KII63425.1 - 0.13 11.7 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Glycos_transf_2 PF00535.21 KII63426.1 - 5e-08 32.8 0.0 0.0023 17.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 ASL_C PF08328.6 KII63426.1 - 0.002 17.9 2.2 0.26 11.1 0.2 2.2 1 1 1 2 2 2 2 Adenylosuccinate lyase C-terminal Glyco_tranf_2_2 PF10111.4 KII63426.1 - 0.0052 15.9 0.3 1.6 7.7 0.0 2.2 1 1 1 2 2 2 2 Glycosyltransferase like family 2 Zn_peptidase PF04228.8 KII63426.1 - 0.066 12.4 0.5 3.8 6.6 0.1 2.2 1 1 1 2 2 2 0 Putative neutral zinc metallopeptidase DUF2087 PF09860.4 KII63426.1 - 0.089 12.5 0.3 0.22 11.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) MENTAL PF10457.4 KII63426.1 - 0.18 11.4 0.9 16 5.0 0.1 2.3 2 0 0 2 2 2 0 Cholesterol-capturing domain YqhR PF11085.3 KII63427.1 - 0.23 10.9 4.2 3.2 7.2 0.7 2.3 2 0 0 2 2 2 0 Conserved membrane protein YqhR Glycos_transf_2 PF00535.21 KII63429.1 - 0.00071 19.2 0.2 0.0011 18.6 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glycos_transf_2 PF00535.21 KII63431.1 - 3.7e-05 23.4 0.2 7.3e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 KII63431.1 - 0.0024 17.5 0.0 0.0037 16.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 KII63431.1 - 0.0027 17.5 0.0 0.0065 16.2 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 ApoB100_C PF12491.3 KII63432.1 - 0.098 12.3 2.5 0.27 10.9 0.6 2.4 2 1 0 2 2 2 0 Apolipoprotein B100 C terminal AT_hook PF02178.14 KII63435.1 - 0.86 9.4 7.7 1.7 8.5 5.4 1.6 1 0 0 1 1 1 0 AT hook motif DUF4501 PF14946.1 KII63437.1 - 0.046 13.2 0.6 0.9 8.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4501) fn3 PF00041.16 KII63438.1 - 1.5e-11 44.2 0.3 2.6e-09 37.0 0.2 2.5 2 1 0 2 2 2 1 Fibronectin type III domain Tissue_fac PF01108.12 KII63438.1 - 0.028 14.1 0.0 0.058 13.1 0.0 1.5 1 1 0 1 1 1 0 Tissue factor zf-CCCH PF00642.19 KII63439.1 - 0.0012 18.5 9.1 0.083 12.5 1.3 3.0 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KII63439.1 - 6.5 6.9 9.0 3.8 7.6 0.7 3.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type RNase_T PF00929.19 KII63440.1 - 1.3e-11 45.0 0.0 1.6e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Exonuclease HSF_DNA-bind PF00447.12 KII63441.1 - 6.5e-22 77.6 3.2 2.9e-20 72.3 0.1 2.8 3 0 0 3 3 3 2 HSF-type DNA-binding DUF496 PF04363.7 KII63441.1 - 0.0057 16.4 1.2 0.013 15.2 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF496) Transposase_22 PF02994.9 KII63441.1 - 0.0096 14.4 1.2 0.017 13.6 0.9 1.3 1 0 0 1 1 1 1 L1 transposable element APG6 PF04111.7 KII63441.1 - 0.12 11.4 3.1 1.5 7.8 0.6 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 RVT_1 PF00078.22 KII63442.1 - 2.5e-15 56.4 0.1 1e-14 54.4 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII63442.1 - 1.6e-07 31.1 0.2 3.6e-07 30.0 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII63442.1 - 2.2e-06 28.0 0.0 5.2e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII63442.1 - 6.2e-06 25.9 0.0 1.5e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII63442.1 - 0.0025 17.7 0.0 0.0054 16.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII63442.1 - 0.016 14.7 0.0 0.043 13.3 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.1 KII63442.1 - 0.049 13.1 3.9 0.13 11.7 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger GCFC PF07842.7 KII63443.1 - 7.1e-36 123.9 4.3 7.1e-36 123.9 3.0 1.9 1 1 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.18 KII63443.1 - 5.6e-16 58.0 1.0 1.1e-15 57.1 0.7 1.5 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.3 KII63443.1 - 3.4e-09 36.7 2.1 7.1e-09 35.7 1.5 1.5 1 0 0 1 1 1 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.2 KII63443.1 - 6.8e-06 25.8 0.8 1.7e-05 24.5 0.5 1.7 1 0 0 1 1 1 1 DExH-box splicing factor binding site Fzo_mitofusin PF04799.8 KII63443.1 - 0.0063 15.9 2.4 0.012 15.0 1.7 1.4 1 0 0 1 1 1 1 fzo-like conserved region Not3 PF04065.10 KII63443.1 - 0.047 12.9 5.7 0.081 12.1 2.1 2.3 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component DDE_Tnp_1_6 PF13751.1 KII63443.1 - 0.17 11.9 0.4 0.37 10.8 0.0 1.8 2 0 0 2 2 2 0 Transposase DDE domain CheZ PF04344.8 KII63443.1 - 0.26 10.9 4.4 0.062 12.9 0.2 2.0 3 0 0 3 3 3 0 Chemotaxis phosphatase, CheZ DUF3901 PF13040.1 KII63443.1 - 0.37 10.1 3.5 5.8 6.2 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3901) Ank_2 PF12796.2 KII63444.1 - 6.1e-48 161.0 9.9 1.9e-16 60.1 0.2 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KII63444.1 - 4.3e-33 111.4 6.3 3.4e-06 26.5 0.1 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.1 KII63444.1 - 8.3e-33 111.6 2.5 3.7e-12 46.0 0.1 5.2 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KII63444.1 - 3.1e-31 107.1 8.6 2.1e-10 40.8 0.1 5.5 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII63444.1 - 1.5e-23 80.5 3.5 0.00021 21.2 0.0 7.0 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 KII63445.1 - 1.1e-10 41.7 0.3 5.5e-05 23.5 0.0 2.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KII63445.1 - 4e-09 35.8 0.4 0.001 18.7 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KII63445.1 - 2.4e-08 34.1 0.1 0.0011 19.2 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KII63445.1 - 7.5e-08 31.8 1.2 0.0011 18.9 0.0 3.4 3 1 1 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 KII63445.1 - 3.6e-07 30.2 0.3 0.014 15.6 0.0 3.4 2 2 2 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KII63446.1 - 5.4e-45 151.6 0.7 2.1e-11 43.9 0.0 5.1 4 1 1 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 KII63446.1 - 2.1e-38 128.1 7.5 5.3e-11 41.7 0.0 8.2 7 2 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 KII63446.1 - 6.5e-38 128.4 10.1 6.7e-12 45.5 0.1 5.9 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII63446.1 - 3.4e-33 112.9 1.1 1.3e-11 44.3 0.0 6.3 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII63446.1 - 3.1e-28 94.9 12.2 9.3e-06 25.4 0.0 8.3 8 1 0 8 8 8 6 Ankyrin repeat SMC_N PF02463.14 KII63447.1 - 2e-24 86.0 13.7 1.4e-23 83.3 9.1 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KII63447.1 - 5.5e-09 36.0 0.0 2.1e-08 34.1 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain Reo_sigmaC PF04582.7 KII63447.1 - 0.0028 16.8 19.0 0.0036 16.5 1.3 3.9 2 1 2 4 4 4 3 Reovirus sigma C capsid protein IncA PF04156.9 KII63447.1 - 0.0081 15.7 17.1 0.0081 15.7 11.8 4.1 1 1 3 4 4 4 3 IncA protein Myosin_tail_1 PF01576.14 KII63447.1 - 0.83 7.2 64.5 0.02 12.6 24.3 2.3 1 1 1 2 2 2 0 Myosin tail CENP-F_leu_zip PF10473.4 KII63448.1 - 2e-05 24.4 14.4 0.0011 18.8 1.4 2.1 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mnd1 PF03962.10 KII63448.1 - 0.0012 18.5 4.5 0.0012 18.5 3.1 2.2 1 1 0 2 2 2 1 Mnd1 family GAS PF13851.1 KII63448.1 - 0.0018 17.5 5.5 0.0018 17.5 3.8 2.1 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding DUF4201 PF13870.1 KII63448.1 - 0.0018 17.7 3.3 0.0018 17.7 2.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) Spc7 PF08317.6 KII63448.1 - 0.0019 16.9 2.9 0.0019 16.9 2.0 2.0 2 0 0 2 2 2 1 Spc7 kinetochore protein LXG PF04740.7 KII63448.1 - 0.0028 17.4 1.8 0.0028 17.4 1.2 2.0 1 1 1 2 2 2 1 LXG domain of WXG superfamily DUF3584 PF12128.3 KII63448.1 - 0.0046 14.3 8.5 0.0059 14.0 5.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Not3 PF04065.10 KII63448.1 - 0.0059 15.9 7.6 0.2 10.9 0.5 2.1 2 0 0 2 2 2 2 Not1 N-terminal domain, CCR4-Not complex component DUF4200 PF13863.1 KII63448.1 - 0.0083 16.0 1.6 0.0083 16.0 1.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) Phage_GP20 PF06810.6 KII63448.1 - 0.013 14.9 6.3 0.013 14.9 4.4 2.5 2 1 0 2 2 2 0 Phage minor structural protein GP20 Lebercilin PF15619.1 KII63448.1 - 0.013 14.9 3.7 0.013 14.9 2.6 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease IncA PF04156.9 KII63448.1 - 0.015 14.9 19.8 0.31 10.5 14.0 2.0 1 1 0 1 1 1 0 IncA protein DUF3086 PF11285.3 KII63448.1 - 0.024 13.4 4.7 0.031 13.1 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) Tropomyosin PF00261.15 KII63448.1 - 0.029 13.4 12.0 0.098 11.7 2.6 2.1 2 0 0 2 2 2 0 Tropomyosin DUF2968 PF11180.3 KII63448.1 - 0.044 13.1 11.3 0.11 11.8 4.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF4164 PF13747.1 KII63448.1 - 0.044 13.9 6.8 0.076 13.1 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) NTR2 PF15458.1 KII63448.1 - 0.053 12.7 8.7 0.1 11.8 6.1 1.5 1 1 0 1 1 1 0 Nineteen complex-related protein 2 PilJ PF13675.1 KII63448.1 - 0.061 13.6 0.8 0.17 12.1 0.4 1.8 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term TPR_MLP1_2 PF07926.7 KII63448.1 - 0.11 12.2 17.0 0.19 11.5 5.5 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein RasGAP_C PF03836.10 KII63448.1 - 0.11 12.1 12.7 3 7.5 4.1 2.9 2 1 1 3 3 3 0 RasGAP C-terminus T4SS PF07996.6 KII63448.1 - 0.11 12.2 6.5 0.16 11.8 4.5 1.2 1 0 0 1 1 1 0 Type IV secretion system proteins Myosin_tail_1 PF01576.14 KII63448.1 - 0.13 9.9 16.2 0.054 11.2 3.8 2.0 1 1 0 2 2 2 0 Myosin tail Reo_sigmaC PF04582.7 KII63448.1 - 0.16 11.0 6.0 0.082 12.0 1.9 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein DUF869 PF05911.6 KII63448.1 - 0.19 9.8 12.4 0.25 9.5 8.6 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) COG2 PF06148.6 KII63448.1 - 0.22 11.3 10.4 0.32 10.8 6.3 1.9 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FlaC_arch PF05377.6 KII63448.1 - 0.23 11.3 14.2 2.5 8.0 1.1 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) MitMem_reg PF13012.1 KII63448.1 - 0.42 10.7 7.1 0.12 12.4 2.8 1.7 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function Filament PF00038.16 KII63448.1 - 0.52 9.7 14.6 0.78 9.1 2.6 2.0 1 1 0 2 2 2 0 Intermediate filament protein P2_Phage_GpR PF06891.6 KII63448.1 - 0.55 10.0 4.1 2.7 7.8 0.0 2.6 3 0 0 3 3 3 0 P2 phage tail completion protein R (GpR) YbaB_DNA_bd PF02575.11 KII63448.1 - 0.57 10.0 4.1 11 6.0 0.0 3.2 3 1 0 3 3 3 0 YbaB/EbfC DNA-binding family Laminin_II PF06009.7 KII63448.1 - 0.64 9.7 12.9 0.48 10.1 3.4 2.1 1 1 1 2 2 2 0 Laminin Domain II Cob_adeno_trans PF01923.13 KII63448.1 - 0.86 9.3 4.9 0.28 10.9 1.1 1.6 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF155 PF02582.9 KII63448.1 - 0.9 9.4 5.9 3.6 7.4 4.1 1.8 1 1 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 ATG16 PF08614.6 KII63448.1 - 1.2 8.9 20.7 0.026 14.3 5.5 2.0 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) V_ATPase_I PF01496.14 KII63448.1 - 1.2 6.8 6.3 1.7 6.4 4.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.2 KII63448.1 - 1.3 8.8 20.2 0.36 10.6 5.4 2.1 1 1 0 1 1 1 0 Tropomyosin like Cortex-I_coil PF09304.5 KII63448.1 - 1.4 9.0 14.3 0.31 11.1 2.8 2.1 2 0 0 2 2 2 0 Cortexillin I, coiled coil Ribosomal_S2 PF00318.15 KII63448.1 - 1.5 8.0 4.7 9 5.4 0.2 2.3 1 1 1 2 2 2 0 Ribosomal protein S2 Stap_Strp_tox_C PF02876.12 KII63448.1 - 1.6 8.9 6.0 9.6 6.4 0.6 2.2 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Lectin_N PF03954.9 KII63448.1 - 1.6 8.1 9.7 15 5.0 6.8 2.3 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain YscO PF07321.7 KII63448.1 - 1.7 8.4 13.9 0.28 11.0 3.7 2.0 1 1 1 2 2 2 0 Type III secretion protein YscO DUF4480 PF13715.1 KII63448.1 - 1.7 8.7 4.2 19 5.3 0.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4480) FlxA PF14282.1 KII63448.1 - 1.8 8.5 23.2 0.46 10.4 0.2 3.1 2 1 1 3 3 3 0 FlxA-like protein FliJ PF02050.11 KII63448.1 - 2.2 8.3 12.1 1.2 9.1 4.3 2.4 1 1 2 3 3 3 0 Flagellar FliJ protein DUF3450 PF11932.3 KII63448.1 - 2.3 7.4 15.4 0.79 8.9 1.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4600 PF15372.1 KII63448.1 - 2.4 8.3 12.7 1.3 9.2 2.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) DUF948 PF06103.6 KII63448.1 - 2.5 8.0 11.4 0.22 11.4 2.5 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Prefoldin_2 PF01920.15 KII63448.1 - 2.7 7.7 22.5 3.8 7.3 1.7 3.1 2 1 1 3 3 3 0 Prefoldin subunit Peptidase_S49_N PF08496.5 KII63448.1 - 3.9 7.2 6.5 1.7 8.4 0.3 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Atg14 PF10186.4 KII63448.1 - 4.2 6.2 12.9 5.7 5.7 8.6 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 YPEB PF14620.1 KII63448.1 - 4.3 6.2 7.5 0.36 9.8 0.9 1.8 1 1 1 2 2 2 0 YpeB sporulation DUF4140 PF13600.1 KII63448.1 - 4.6 7.7 10.2 3.6 8.0 1.4 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) IFT57 PF10498.4 KII63448.1 - 5.2 5.7 14.2 17 4.0 9.8 1.7 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 WEMBL PF05701.6 KII63448.1 - 5.3 5.3 16.1 0.13 10.7 3.1 1.9 1 1 0 2 2 2 0 Weak chloroplast movement under blue light DUF1664 PF07889.7 KII63448.1 - 6.1 6.6 11.8 0.9 9.3 2.7 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) AAA_13 PF13166.1 KII63448.1 - 6.4 5.1 16.3 0.23 9.8 2.2 1.9 1 1 1 2 2 2 0 AAA domain XhlA PF10779.4 KII63448.1 - 6.8 6.6 15.8 0.11 12.3 2.1 2.3 2 0 0 2 2 2 0 Haemolysin XhlA CCDC-167 PF15188.1 KII63448.1 - 6.9 6.6 15.9 3.8 7.5 3.9 2.4 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Spc24 PF08286.6 KII63448.1 - 7.3 6.3 20.3 6.7 6.4 1.9 3.0 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 Snapin_Pallidin PF14712.1 KII63448.1 - 7.6 6.9 15.7 1.3 9.4 5.7 2.5 2 1 0 2 2 2 0 Snapin/Pallidin Jnk-SapK_ap_N PF09744.4 KII63448.1 - 7.7 6.4 14.6 58 3.6 10.2 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Seryl_tRNA_N PF02403.17 KII63448.1 - 8.1 6.5 17.4 2.8 8.0 3.7 2.6 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Prefoldin PF02996.12 KII63448.1 - 9 5.9 19.9 1 9.0 1.2 3.1 2 1 1 3 3 3 0 Prefoldin subunit Allexi_40kDa PF05549.6 KII63448.1 - 9.6 5.4 11.3 0.88 8.8 2.2 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein SMC_N PF02463.14 KII63449.1 - 1.7e-33 115.7 0.7 2.2e-33 115.3 0.5 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KII63449.1 - 5.4e-15 56.2 1.0 6e-15 56.1 0.7 1.1 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KII63449.1 - 5.4e-07 29.8 1.1 6.3e-07 29.6 0.8 1.2 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.1 KII63449.1 - 4.9e-06 25.8 0.7 5.2e-06 25.7 0.5 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 KII63449.1 - 3.4e-05 23.2 0.3 7e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain Folate_rec PF03024.9 KII63455.1 - 1e-07 31.7 2.3 1.1e-07 31.6 1.6 1.0 1 0 0 1 1 1 1 Folate receptor family Toxin_7 PF05980.7 KII63455.1 - 0.11 12.5 1.9 0.11 12.5 1.3 1.7 2 0 0 2 2 2 0 Toxin 7 TraW_N PF12477.3 KII63455.1 - 0.11 12.4 0.1 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Sex factor F TraW protein N terminal Folate_rec PF03024.9 KII63456.1 - 1.3e-31 109.5 18.4 1.7e-31 109.0 12.8 1.1 1 0 0 1 1 1 1 Folate receptor family SAYSvFN PF10260.4 KII63458.1 - 0.015 15.0 0.2 5.9 6.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) MpPF1 PF07668.6 KII63459.1 - 0.049 12.7 0.1 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 M penetrans paralogue family 1 Rtf2 PF04641.7 KII63460.1 - 9.9e-07 28.2 14.6 0.0022 17.2 4.9 3.0 1 1 3 4 4 4 2 Rtf2 RING-finger PRP21_like_P PF12230.3 KII63460.1 - 0.0074 15.8 10.0 0.53 9.7 5.0 2.5 2 1 0 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein U-box PF04564.10 KII63460.1 - 0.017 15.0 0.0 0.59 10.1 0.0 2.9 3 0 0 3 3 3 0 U-box domain zf-Nse PF11789.3 KII63460.1 - 0.024 14.1 1.2 1.1 8.8 0.0 3.1 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit Pkinase PF00069.20 KII63462.1 - 2.9e-49 167.5 0.4 6e-49 166.5 0.3 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII63462.1 - 2.2e-23 82.6 0.0 7.1e-23 80.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KII63462.1 - 4.8e-05 22.4 0.0 8.5e-05 21.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like eIF2A PF08662.6 KII63464.1 - 0.0014 18.4 0.5 0.17 11.5 0.0 2.8 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A DPPIV_N PF00930.16 KII63464.1 - 0.019 13.5 0.2 0.44 9.0 0.1 2.3 1 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF3716 PF12511.3 KII63466.1 - 0.2 11.2 1.9 0.26 10.9 0.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3716) ODR4-like PF14778.1 KII63468.1 - 1.8e-16 59.8 0.0 8.5e-15 54.2 0.0 2.7 1 1 0 1 1 1 1 Olfactory receptor 4-like Sirohm_synth_C PF14823.1 KII63468.1 - 0.01 15.1 0.0 0.025 13.8 0.0 1.7 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal Asp PF00026.18 KII63469.1 - 1.6e-38 132.7 1.0 2.7e-38 132.0 0.7 1.4 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 KII63469.1 - 5.1e-09 35.8 0.0 1e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.1 KII63469.1 - 0.00024 21.0 0.0 0.0018 18.2 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal NCU-G1 PF15065.1 KII63470.1 - 5.8e-08 31.8 3.0 2.1e-07 29.9 2.1 1.8 1 1 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 GP41 PF00517.12 KII63470.1 - 0.044 13.3 0.5 0.11 12.0 0.4 1.6 1 0 0 1 1 1 0 Retroviral envelope protein DUF4389 PF14333.1 KII63470.1 - 2.6 7.7 5.5 0.72 9.6 1.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) HEAT PF02985.17 KII63471.1 - 7.9e-07 28.6 5.1 0.0061 16.5 0.0 4.9 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.1 KII63471.1 - 1.3e-06 28.5 0.0 0.03 14.6 0.0 3.4 2 1 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.1 KII63471.1 - 0.003 17.9 0.0 0.49 10.9 0.0 3.6 4 0 0 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KII63471.1 - 0.0034 17.7 3.8 0.78 10.1 0.0 3.7 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.15 KII63471.1 - 0.0041 15.5 3.7 0.0082 14.5 0.0 2.5 1 1 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.2 KII63471.1 - 0.033 14.0 2.0 0.16 11.7 0.0 2.6 2 2 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 PBP_dimer PF03717.10 KII63471.1 - 0.046 13.7 0.0 0.14 12.1 0.0 1.8 1 1 0 1 1 1 0 Penicillin-binding Protein dimerisation domain Peptidase_M9_N PF08453.5 KII63471.1 - 0.11 11.8 4.2 0.13 11.6 0.4 2.6 2 1 1 3 3 3 0 Peptidase family M9 N-terminal Phage_connect_1 PF05135.8 KII63472.1 - 0.066 13.3 1.9 0.095 12.8 1.3 1.3 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein L_lactis_RepB_C PF06430.7 KII63472.1 - 0.11 12.5 0.8 0.16 12.0 0.6 1.4 1 1 0 1 1 1 0 Lactococcus lactis RepB C-terminus rve_2 PF13333.1 KII63475.1 - 0.062 13.3 0.4 3.1 7.9 0.0 2.8 2 0 0 2 2 2 0 Integrase core domain ER_lumen_recept PF00810.13 KII63476.1 - 4.5e-47 160.2 11.0 7.9e-47 159.4 7.6 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor DDE_3 PF13358.1 KII63476.1 - 0.00074 19.2 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease PQ-loop PF04193.9 KII63476.1 - 0.075 12.5 11.3 0.085 12.4 0.1 3.4 3 0 0 3 3 3 0 PQ loop repeat Sugar_tr PF00083.19 KII63477.1 - 1.3e-42 145.9 36.3 2.4e-42 145.1 25.2 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII63477.1 - 8e-07 28.0 21.4 8e-07 28.0 14.8 3.2 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF3325 PF11804.3 KII63477.1 - 0.033 14.1 0.1 0.033 14.1 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3325) Gag_p12 PF01141.13 KII63479.1 - 0.044 13.9 2.0 1.1 9.4 0.1 2.3 2 0 0 2 2 2 0 Gag polyprotein, inner coat protein p12 Ski_Sno PF02437.12 KII63481.1 - 0.081 12.4 0.1 0.16 11.5 0.0 1.5 2 0 0 2 2 2 0 SKI/SNO/DAC family Ribosomal_S2 PF00318.15 KII63482.1 - 5.2e-41 140.1 4.3 4.7e-20 71.7 0.2 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 DUF1877 PF08974.5 KII63482.1 - 0.041 13.5 0.0 0.061 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) Sororin PF09666.5 KII63483.1 - 0.012 15.8 0.6 0.024 14.8 0.4 1.6 1 0 0 1 1 1 0 Sororin protein ISAV_HA PF06215.6 KII63483.1 - 0.034 12.4 0.0 0.041 12.1 0.0 1.2 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin Guanylate_cyc PF00211.15 KII63483.1 - 0.057 12.7 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Sugar_tr PF00083.19 KII63485.1 - 8.7e-09 34.4 3.8 9.7e-09 34.2 2.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII63485.1 - 0.00015 20.5 3.2 0.00019 20.3 2.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KII63486.1 - 1.5e-30 106.2 19.0 1.6e-30 106.0 13.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII63486.1 - 6.6e-08 31.6 19.9 6.6e-08 31.6 13.8 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MscL PF01741.13 KII63486.1 - 0.049 13.7 0.7 0.049 13.7 0.5 1.9 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL DUF1189 PF06691.6 KII63486.1 - 2.2 7.5 14.0 0.026 13.8 3.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) MerC PF03203.9 KII63486.1 - 7.3 6.9 11.5 4.1 7.7 3.2 2.4 2 0 0 2 2 2 0 MerC mercury resistance protein MFS_2 PF13347.1 KII63486.1 - 9.5 4.4 22.5 3.7 5.8 11.2 2.0 1 1 1 2 2 2 0 MFS/sugar transport protein LSM PF01423.17 KII63487.1 - 3.5e-17 61.7 0.1 4.4e-17 61.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain MmlI PF09448.5 KII63489.1 - 0.011 15.4 0.2 0.044 13.5 0.1 2.0 2 0 0 2 2 2 0 Methylmuconolactone methyl-isomerase DUF4188 PF13826.1 KII63489.1 - 0.051 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4188) DDE_3 PF13358.1 KII63490.1 - 3.2e-26 91.8 0.1 4.3e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Syntaphilin PF15290.1 KII63491.1 - 0.0075 15.7 0.1 0.014 14.8 0.0 1.6 1 1 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp HNF-1_N PF04814.8 KII63492.1 - 1 9.4 9.4 2.2 8.3 0.5 3.3 3 0 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Exo_endo_phos_2 PF14529.1 KII63494.1 - 2.2e-08 33.7 2.1 2.5e-08 33.5 0.4 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 KII63494.1 - 0.01 15.7 0.1 0.024 14.5 0.1 1.4 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Ribosomal_S17 PF00366.15 KII63495.1 - 2.3e-26 91.6 3.3 3.7e-26 90.9 2.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 DUF1064 PF06356.6 KII63495.1 - 0.024 14.6 0.1 0.042 13.8 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1064) Telomere_reg-2 PF10193.4 KII63496.1 - 6.5e-05 23.1 0.1 0.00031 20.9 0.0 2.1 1 1 1 2 2 2 1 Telomere length regulation protein Aminotran_1_2 PF00155.16 KII63497.1 - 3.8e-70 236.6 0.0 4.4e-70 236.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 KII63497.1 - 1e-06 27.7 0.0 1.7e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 KII63497.1 - 1.7e-05 23.3 0.0 2.5e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 KII63497.1 - 0.00024 20.3 0.0 0.00036 19.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KII63497.1 - 0.48 9.3 1.2 3.1 6.7 0.8 1.9 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family UQ_con PF00179.21 KII63498.1 - 1.5e-25 89.3 1.3 1.9e-25 88.9 0.9 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Transket_pyr PF02779.19 KII63499.1 - 1.2e-59 200.7 0.0 2e-59 200.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 KII63499.1 - 7.6e-55 185.7 0.0 1.1e-54 185.1 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DUF4082 PF13313.1 KII63500.1 - 0.016 14.6 0.0 0.077 12.4 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4082) Cullin PF00888.17 KII63501.1 - 6.5e-05 21.6 1.8 8.3e-05 21.3 1.3 1.2 1 0 0 1 1 1 1 Cullin family HTH_Mga PF08280.6 KII63501.1 - 0.0048 16.6 0.0 0.015 15.0 0.0 1.8 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain CRISPR_Cas2 PF09827.4 KII63502.1 - 0.048 13.7 1.9 2.6 8.2 0.2 2.7 2 0 0 2 2 2 0 CRISPR associated protein Cas2 Nop PF01798.13 KII63504.1 - 1.3e-56 190.0 0.5 4.4e-56 188.3 0.0 2.0 3 0 0 3 3 3 1 Putative snoRNA binding domain NOSIC PF08060.8 KII63504.1 - 2.3e-24 84.9 0.3 5.2e-24 83.7 0.2 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain FATC PF02260.15 KII63504.1 - 0.091 12.2 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 FATC domain TatD_DNase PF01026.16 KII63505.1 - 1e-47 162.4 0.0 1.2e-47 162.2 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase AdoMetDC_leader PF08132.6 KII63507.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide Ldh_1_N PF00056.18 KII63508.1 - 1.1e-26 93.3 0.0 1.4e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 KII63508.1 - 0.0018 18.0 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Asp_protease_2 PF13650.1 KII63510.1 - 3.3e-05 24.2 0.0 6.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII63510.1 - 0.00017 21.3 0.3 0.00042 20.1 0.2 1.7 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.1 KII63510.1 - 0.037 13.8 0.0 0.22 11.3 0.0 2.0 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease QLQ PF08880.6 KII63510.1 - 0.044 13.2 0.5 0.044 13.2 0.3 1.7 2 0 0 2 2 2 0 QLQ RVT_1 PF00078.22 KII63511.1 - 1.1e-16 60.8 0.0 3.6e-16 59.1 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF781 PF05612.7 KII63511.1 - 0.061 12.0 0.0 0.14 10.8 0.0 1.6 2 0 0 2 2 2 0 Mouse protein of unknown function (DUF781) rve PF00665.21 KII63512.1 - 1.4e-20 73.5 0.0 2.5e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII63512.1 - 0.0024 17.3 0.1 0.013 14.9 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Transglut_core PF01841.14 KII63514.1 - 5.8e-05 23.2 0.0 6.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF3194 PF11419.3 KII63518.1 - 0.037 14.2 0.0 0.084 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) Transglut_core PF01841.14 KII63519.1 - 2.1e-05 24.7 0.0 4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Serpin PF00079.15 KII63521.1 - 1.3e-17 64.0 0.8 1.5e-17 63.8 0.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) KTSC PF13619.1 KII63521.1 - 0.0075 15.8 0.1 0.02 14.5 0.1 1.7 1 0 0 1 1 1 1 KTSC domain Cu-oxidase_2 PF07731.9 KII63521.1 - 0.055 12.9 0.1 5 6.6 0.0 2.1 2 0 0 2 2 2 0 Multicopper oxidase Serpin PF00079.15 KII63524.1 - 5.8e-42 144.1 2.9 1.2e-41 143.1 2.0 1.5 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1510 PF07423.6 KII63524.1 - 0.31 10.3 6.6 0.62 9.3 4.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TIP120 PF08623.5 KII63526.1 - 0.021 14.3 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) rve PF00665.21 KII63528.1 - 3.2e-28 98.2 0.1 5e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII63528.1 - 7.9e-05 22.1 0.0 0.00028 20.3 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain UBN2 PF14223.1 KII63529.1 - 0.0011 18.7 0.5 0.015 15.1 0.0 2.5 1 1 1 2 2 2 1 gag-polypeptide of LTR copia-type VitD-bind_III PF09164.5 KII63529.1 - 0.083 12.5 0.4 0.24 11.0 0.0 2.0 2 0 0 2 2 2 0 Vitamin D binding protein, domain III DDE_Tnp_IS1595 PF12762.2 KII63530.1 - 5.5e-13 49.0 0.0 1.5e-12 47.6 0.0 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII63531.1 - 1.2e-13 51.0 0.3 1.7e-07 31.0 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF1627 PF07789.7 KII63531.1 - 0.069 12.6 0.3 0.11 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1627) DDE_3 PF13358.1 KII63532.1 - 3.3e-06 26.8 0.1 1.5e-05 24.7 0.0 2.0 3 0 0 3 3 3 1 DDE superfamily endonuclease CaATP_NAI PF12515.3 KII63536.1 - 0.027 13.9 0.0 0.063 12.7 0.0 1.6 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain DUF2757 PF10955.3 KII63536.1 - 0.15 12.2 0.2 7.9 6.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2757) BNR PF02012.15 KII63538.1 - 7.2e-05 22.0 0.4 0.36 10.8 0.0 3.7 3 0 0 3 3 3 1 BNR/Asp-box repeat UCR_UQCRX_QCR9 PF05365.7 KII63538.1 - 0.039 13.6 1.1 0.33 10.6 0.1 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like zf-RING-like PF08746.6 KII63538.1 - 0.32 11.0 0.1 0.32 11.0 0.1 2.5 2 1 0 2 2 2 0 RING-like domain BNR PF02012.15 KII63539.1 - 0.001 18.5 7.0 0.47 10.4 0.0 3.3 2 0 0 2 2 2 2 BNR/Asp-box repeat DDE_3 PF13358.1 KII63541.1 - 0.004 16.8 0.0 0.29 10.8 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF2256 PF10013.4 KII63544.1 - 0.032 13.9 0.5 0.29 10.9 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) UCR_UQCRX_QCR9 PF05365.7 KII63545.1 - 0.012 15.2 0.9 2.6 7.7 0.6 2.4 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like BNR PF02012.15 KII63545.1 - 1.5 8.9 5.6 6.5 7.0 0.5 3.6 3 0 0 3 3 3 0 BNR/Asp-box repeat Adeno_E4_34 PF04528.8 KII63545.1 - 1.6 8.3 3.8 3.3 7.2 0.0 2.4 2 1 1 3 3 3 0 Adenovirus early E4 34 kDa protein conserved region CHB_HEX_C_1 PF13290.1 KII63549.1 - 0.046 13.5 0.2 0.084 12.6 0.1 1.4 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain DUF3269 PF11673.3 KII63549.1 - 0.048 14.0 0.3 0.11 13.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3269) BNR PF02012.15 KII63549.1 - 3.7 7.7 8.6 18 5.6 0.0 4.1 4 0 0 4 4 4 0 BNR/Asp-box repeat zf-RING-like PF08746.6 KII63550.1 - 0.13 12.3 3.5 1.7 8.6 0.0 3.3 3 0 0 3 3 3 0 RING-like domain BNR PF02012.15 KII63550.1 - 0.16 11.9 1.2 23 5.3 0.6 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat BNR PF02012.15 KII63551.1 - 3.6e-06 25.9 1.7 0.043 13.6 0.1 4.3 3 0 0 3 3 3 2 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII63553.1 - 6.2e-09 35.6 17.3 1.5e-08 34.3 10.5 2.3 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A Defensin_beta PF00711.14 KII63553.1 - 0.01 15.7 7.0 0.063 13.2 5.3 2.0 2 0 0 2 2 2 0 Beta defensin MYCBPAP PF14646.1 KII63554.1 - 0.036 12.8 0.2 0.042 12.5 0.1 1.0 1 0 0 1 1 1 0 MYCBP-associated protein family REJ PF02010.10 KII63554.1 - 0.038 12.3 0.0 0.042 12.1 0.0 1.1 1 0 0 1 1 1 0 REJ domain RVT_1 PF00078.22 KII63557.1 - 0.00038 19.8 0.0 0.0011 18.3 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BNR PF02012.15 KII63559.1 - 0.00025 20.3 0.2 0.28 11.1 0.0 3.6 2 0 0 2 2 2 2 BNR/Asp-box repeat Imm23 PF15593.1 KII63560.1 - 0.028 14.6 0.9 0.033 14.4 0.6 1.2 1 0 0 1 1 1 0 Immunity protein 23 His_binding PF02098.11 KII63560.1 - 0.17 11.7 0.9 0.19 11.5 0.6 1.2 1 0 0 1 1 1 0 Tick histamine binding protein Ldl_recept_a PF00057.13 KII63561.1 - 2.8e-07 30.2 9.4 2.8e-07 30.2 6.5 3.5 3 1 0 3 3 3 2 Low-density lipoprotein receptor domain class A GP40 PF11025.3 KII63562.1 - 0.081 12.4 0.5 0.15 11.6 0.3 1.4 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium Ldl_recept_a PF00057.13 KII63565.1 - 1e-05 25.2 15.3 1.9e-05 24.4 9.0 2.8 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII63565.1 - 0.0044 16.6 6.3 5.6 7.2 0.0 4.2 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR PF02012.15 KII63566.1 - 0.015 15.0 1.0 0.89 9.6 0.0 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat BNR_2 PF13088.1 KII63566.1 - 0.049 12.9 0.0 0.14 11.3 0.0 1.7 1 1 0 1 1 1 0 BNR repeat-like domain Ldl_recept_a PF00057.13 KII63568.1 - 0.0018 18.1 1.5 0.0026 17.6 1.1 1.3 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII63568.1 - 0.046 13.5 7.7 3.3 7.9 0.0 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat Gal-3-0_sulfotr PF06990.6 KII63570.1 - 2.2e-24 85.8 0.5 1.8e-23 82.8 0.4 1.9 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase YmgB PF10798.3 KII63570.1 - 0.076 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR Ribosomal_L14 PF00238.14 KII63571.1 - 0.0052 16.5 0.2 0.01 15.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e DDE_Tnp_IS1595 PF12762.2 KII63572.1 - 1.7e-20 73.3 0.0 2.3e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Thioredoxin PF00085.15 KII63573.1 - 2.7e-32 110.5 0.0 3.7e-26 90.8 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_2 PF13098.1 KII63573.1 - 1e-07 32.1 0.1 0.0001 22.4 0.1 3.4 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_6 PF13848.1 KII63573.1 - 3e-05 23.9 2.9 0.00022 21.1 1.1 2.6 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KII63573.1 - 3.6e-05 23.7 2.3 0.04 14.0 0.0 3.9 3 1 0 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.1 KII63573.1 - 0.00016 21.6 0.0 0.00038 20.4 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.15 KII63574.1 - 3.1e-35 120.0 0.0 2.6e-31 107.3 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 KII63574.1 - 5.6e-08 32.9 0.1 6.8e-06 26.2 0.1 3.3 3 1 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_6 PF13848.1 KII63574.1 - 5.7e-07 29.5 0.0 1.5e-05 24.8 0.0 2.3 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KII63574.1 - 9.9e-06 25.4 0.0 3.2e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.1 KII63574.1 - 3.4e-05 23.8 0.0 0.00034 20.6 0.0 2.7 3 1 0 3 3 3 1 Thioredoxin-like DUF4371 PF14291.1 KII63575.1 - 2.8e-12 46.6 0.3 1.2e-11 44.6 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.9 KII63575.1 - 3.6e-06 26.5 0.1 9e-06 25.2 0.1 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Med9 PF07544.8 KII63575.1 - 0.83 9.4 4.1 1.3 8.8 0.0 3.0 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Ldh_1_C PF02866.13 KII63576.1 - 4.5e-29 101.4 0.0 7.1e-29 100.7 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 KII63576.1 - 6.6e-08 32.4 0.4 2.1e-07 30.8 0.1 2.0 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain DDE_3 PF13358.1 KII63577.1 - 1.6e-12 47.3 0.1 1.9e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII63577.1 - 0.00034 20.6 0.0 0.00052 20.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Ldh_1_C PF02866.13 KII63578.1 - 2.7e-29 102.1 0.0 3.1e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain DDE_Tnp_IS1595 PF12762.2 KII63579.1 - 1.7e-12 47.3 0.1 6.8e-12 45.4 0.0 2.0 2 1 0 2 2 2 1 ISXO2-like transposase domain Thioredoxin PF00085.15 KII63580.1 - 9.2e-29 99.1 0.3 9.3e-26 89.5 0.1 3.2 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_6 PF13848.1 KII63580.1 - 1.3e-09 38.1 3.6 0.00061 19.6 0.1 3.1 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.1 KII63580.1 - 6.9e-09 35.8 0.5 2.7e-05 24.3 0.2 3.5 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KII63580.1 - 3.9e-08 33.2 2.1 0.00045 20.2 0.1 3.3 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_3 PF13192.1 KII63580.1 - 0.00011 21.9 0.0 0.0012 18.6 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_7 PF13899.1 KII63580.1 - 0.00012 22.0 0.0 0.00065 19.6 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like DUF953 PF06110.6 KII63580.1 - 0.0071 15.7 0.2 0.07 12.5 0.1 2.3 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF953) HyaE PF07449.6 KII63580.1 - 0.026 14.3 0.0 14 5.6 0.0 3.5 3 1 1 4 4 4 0 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.1 KII63580.1 - 0.033 13.7 0.4 8.9 5.8 0.1 2.7 2 1 1 3 3 3 0 Thioredoxin Gal-3-0_sulfotr PF06990.6 KII63581.1 - 2.1e-29 102.3 3.9 9.5e-29 100.2 2.7 1.8 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase rve PF00665.21 KII63584.1 - 9.1e-29 100.0 0.0 1.5e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII63584.1 - 0.00025 21.0 0.3 0.001 19.0 0.0 1.9 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII63584.1 - 0.0037 16.7 0.0 0.0089 15.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF4522 PF15022.1 KII63584.1 - 0.059 13.0 0.1 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) BNR PF02012.15 KII63587.1 - 4.9e-05 22.5 1.0 2.4 8.3 0.1 4.2 4 0 0 4 4 4 3 BNR/Asp-box repeat DDE_3 PF13358.1 KII63588.1 - 2.6e-09 36.9 0.0 9.2e-09 35.2 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII63588.1 - 0.0001 21.7 0.0 0.00018 20.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII63588.1 - 0.0087 16.8 1.2 0.0093 16.7 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII63588.1 - 0.029 14.5 0.1 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix HTH_17 PF12728.2 KII63588.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain PhoU PF01895.14 KII63589.1 - 0.024 15.0 0.5 0.038 14.4 0.1 1.5 1 1 1 2 2 2 0 PhoU domain UPF0066 PF01980.11 KII63589.1 - 0.063 13.2 0.0 0.077 12.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0066 DUF953 PF06110.6 KII63590.1 - 0.019 14.4 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) DUF4275 PF14101.1 KII63591.1 - 2 8.5 7.8 1.1 9.3 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4275) RVT_1 PF00078.22 KII63596.1 - 1.9e-09 37.2 0.1 3.9e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII63596.1 - 0.00045 20.3 0.0 0.00098 19.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain CALCOCO1 PF07888.6 KII63598.1 - 0.00011 20.7 11.9 0.00036 18.9 4.5 2.0 1 1 1 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like Laminin_I PF06008.9 KII63598.1 - 0.0014 18.0 7.6 0.0019 17.5 5.3 1.2 1 0 0 1 1 1 1 Laminin Domain I Myosin_tail_1 PF01576.14 KII63598.1 - 0.0062 14.3 12.4 0.0098 13.6 8.6 1.3 1 1 0 1 1 1 1 Myosin tail ATP-synt_D PF01813.12 KII63598.1 - 0.012 15.1 5.7 0.39 10.2 0.7 2.4 2 1 0 2 2 2 0 ATP synthase subunit D OGG_N PF07934.7 KII63598.1 - 0.012 15.5 4.0 0.047 13.6 0.7 2.2 2 0 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain BRE1 PF08647.6 KII63598.1 - 0.013 15.4 2.4 0.013 15.4 1.7 3.1 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase COG2 PF06148.6 KII63598.1 - 0.017 14.9 4.0 1.5 8.6 0.1 2.9 1 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 polyprenyl_synt PF00348.12 KII63598.1 - 0.025 13.4 5.7 0.095 11.5 1.0 2.3 1 1 1 2 2 2 0 Polyprenyl synthetase Reo_sigmaC PF04582.7 KII63598.1 - 0.029 13.5 0.6 0.033 13.3 0.4 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Macoilin PF09726.4 KII63598.1 - 0.035 12.3 9.3 0.047 11.9 6.4 1.2 1 0 0 1 1 1 0 Transmembrane protein Nup88 PF10168.4 KII63598.1 - 0.037 11.8 14.0 0.038 11.8 9.7 1.0 1 0 0 1 1 1 0 Nuclear pore component APG6 PF04111.7 KII63598.1 - 0.068 12.1 12.4 0.26 10.3 8.8 1.7 1 1 0 1 1 1 0 Autophagy protein Apg6 DUF1664 PF07889.7 KII63598.1 - 0.081 12.7 11.8 0.13 12.0 2.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Cauli_DNA-bind PF03310.8 KII63598.1 - 0.093 12.5 5.9 0.16 11.7 4.1 1.5 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein Lzipper-MIP1 PF14389.1 KII63598.1 - 0.12 12.5 1.8 0.23 11.5 1.2 1.4 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Baculo_PEP_C PF04513.7 KII63598.1 - 0.13 12.1 7.6 0.13 12.0 4.0 1.8 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ArdA PF07275.6 KII63598.1 - 0.2 11.8 3.9 1.1 9.5 2.7 2.0 1 1 0 1 1 1 0 Antirestriction protein (ArdA) Talin_middle PF09141.5 KII63598.1 - 0.22 11.1 1.4 0.4 10.3 0.2 2.0 2 1 1 3 3 2 0 Talin, middle domain Laminin_II PF06009.7 KII63598.1 - 0.26 11.0 9.5 1.9 8.2 3.4 2.3 1 1 1 2 2 2 0 Laminin Domain II MscS_porin PF12795.2 KII63598.1 - 0.28 10.4 5.4 0.58 9.4 3.7 1.6 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF1515 PF07439.6 KII63598.1 - 0.29 10.9 1.3 0.32 10.8 0.4 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF1515) DUF2730 PF10805.3 KII63598.1 - 0.32 10.7 5.8 19 5.0 2.2 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Seryl_tRNA_N PF02403.17 KII63598.1 - 0.34 10.9 16.2 2.2 8.3 1.3 3.1 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain BLOC1_2 PF10046.4 KII63598.1 - 0.35 11.0 17.8 0.17 12.0 1.4 3.3 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Jnk-SapK_ap_N PF09744.4 KII63598.1 - 0.36 10.7 13.5 4.1 7.3 2.9 2.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF1140 PF06600.6 KII63598.1 - 0.6 10.2 8.3 0.089 12.9 2.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1140) GLTP PF08718.6 KII63598.1 - 0.91 9.5 8.5 0.83 9.6 0.8 2.6 1 1 1 2 2 2 0 Glycolipid transfer protein (GLTP) YgbB PF02542.11 KII63598.1 - 0.93 9.2 4.2 0.82 9.4 1.5 2.0 1 1 1 2 2 2 0 YgbB family AATF-Che1 PF13339.1 KII63598.1 - 1 9.5 8.0 8.4 6.5 0.3 2.4 1 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Nsp1_C PF05064.8 KII63598.1 - 1.1 8.8 10.9 1.2 8.7 3.3 2.8 1 1 2 3 3 3 0 Nsp1-like C-terminal region Fib_alpha PF08702.5 KII63598.1 - 1.3 9.1 16.3 0.17 11.9 6.2 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.14 KII63598.1 - 1.7 6.4 8.9 1.8 6.2 6.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Uds1 PF15456.1 KII63598.1 - 2.3 8.2 7.0 2.6 8.0 3.1 2.1 1 1 1 2 2 2 0 Up-regulated During Septation Vps51 PF08700.6 KII63598.1 - 2.6 7.9 10.9 0.49 10.2 0.5 3.2 1 1 3 4 4 4 0 Vps51/Vps67 NPV_P10 PF05531.7 KII63598.1 - 3.2 8.0 9.9 3.9 7.7 1.9 2.9 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein LOH1CR12 PF10158.4 KII63598.1 - 3.3 7.5 7.6 0.77 9.5 2.8 1.7 2 0 0 2 2 2 0 Tumour suppressor protein Synaptobrevin PF00957.16 KII63598.1 - 4.4 6.9 9.4 1.1 8.8 2.5 2.5 2 1 0 2 2 2 0 Synaptobrevin NuA4 PF09340.5 KII63598.1 - 5.8 6.6 7.7 1 9.0 0.7 2.8 1 1 1 3 3 3 0 Histone acetyltransferase subunit NuA4 Nup54 PF13874.1 KII63598.1 - 6.5 6.4 7.1 21 4.7 2.3 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 IncA PF04156.9 KII63598.1 - 6.8 6.2 9.8 4.3 6.9 0.8 2.1 1 1 1 2 2 2 0 IncA protein Peptidase_C65 PF10275.4 KII63600.1 - 0.019 14.3 1.0 0.021 14.1 0.7 1.1 1 0 0 1 1 1 0 Peptidase C65 Otubain Telomere_reg-2 PF10193.4 KII63600.1 - 0.061 13.5 0.9 0.083 13.1 0.7 1.3 1 0 0 1 1 1 0 Telomere length regulation protein Cir_N PF10197.4 KII63604.1 - 0.031 14.3 0.8 0.048 13.6 0.6 1.2 1 0 0 1 1 1 0 N-terminal domain of CBF1 interacting co-repressor CIR Archease PF01951.11 KII63605.1 - 1.2e-45 154.8 1.8 1.4e-45 154.6 1.3 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) DUF4370 PF14290.1 KII63605.1 - 0.042 13.3 0.2 0.062 12.7 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4370) Prenyltransf PF01255.14 KII63606.1 - 8.8e-42 142.7 0.4 1e-41 142.4 0.3 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DDE_Tnp_IS1595 PF12762.2 KII63607.1 - 5.2e-10 39.3 0.0 1.1e-09 38.3 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain Kelch_3 PF13415.1 KII63607.1 - 0.06 13.5 0.0 2.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain AhpC-TSA_2 PF13911.1 KII63608.1 - 0.0033 17.3 0.0 0.0048 16.8 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AJAP1_PANP_C PF15298.1 KII63614.1 - 0.15 11.8 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus zinc_ribbon_4 PF13717.1 KII63615.1 - 0.15 11.7 0.1 0.34 10.6 0.0 1.7 2 0 0 2 2 2 0 zinc-ribbon domain CENP-B_N PF04218.8 KII63617.1 - 0.00013 21.3 0.0 0.00024 20.4 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.1 KII63617.1 - 0.0043 16.6 0.1 0.0086 15.6 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII63617.1 - 0.022 14.7 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_19 PF12844.2 KII63617.1 - 0.079 13.0 0.1 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain I-set PF07679.11 KII63618.1 - 3.5e-11 42.8 0.0 4.8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.1 KII63618.1 - 4.7e-06 26.6 0.0 6.6e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.1 KII63618.1 - 2.4e-05 24.7 0.5 4.1e-05 24.0 0.3 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.12 KII63618.1 - 0.00072 19.4 0.1 0.0043 16.9 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.20 KII63618.1 - 0.026 14.6 0.4 0.089 12.9 0.3 1.8 1 1 0 1 1 1 0 Immunoglobulin domain DUF4087 PF13316.1 KII63618.1 - 0.12 12.5 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4087) SNAP PF14938.1 KII63619.1 - 1.4e-18 67.0 5.2 2.3e-18 66.3 3.6 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NADH_4Fe-4S PF10589.4 KII63619.1 - 0.068 12.3 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region TPR_6 PF13174.1 KII63619.1 - 0.11 13.0 0.8 9.5 6.9 0.2 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4473 PF14747.1 KII63619.1 - 0.23 11.7 4.7 9.9 6.4 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) TPR_11 PF13414.1 KII63619.1 - 0.47 10.1 3.0 1.4 8.6 0.6 2.6 1 1 2 3 3 3 0 TPR repeat DUF2600 PF10776.4 KII63620.1 - 0.13 11.1 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) Transglut_N PF00868.15 KII63621.1 - 3.7e-07 30.2 0.0 5.2e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.14 KII63622.1 - 3.3e-06 27.2 0.0 3.9e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_C PF00927.17 KII63623.1 - 0.03 14.3 0.2 2.4 8.2 0.1 2.7 2 0 0 2 2 2 0 Transglutaminase family, C-terminal ig like domain Collagen PF01391.13 KII63628.1 - 0.01 15.3 4.5 0.022 14.3 3.1 1.6 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Annexin PF00191.15 KII63629.1 - 2.7e-05 23.9 0.1 0.00059 19.6 0.0 2.3 2 0 0 2 2 2 1 Annexin PA_decarbox PF05870.6 KII63630.1 - 0.038 13.4 0.1 0.064 12.7 0.1 1.3 1 0 0 1 1 1 0 Phenolic acid decarboxylase (PAD) TFIIF_alpha PF05793.7 KII63633.1 - 0.17 10.2 7.5 0.19 10.0 5.2 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DDE_3 PF13358.1 KII63635.1 - 0.00071 19.3 0.1 0.00094 18.9 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Oxidored_q1_N PF00662.15 KII63635.1 - 0.026 14.0 1.4 0.05 13.1 0.2 2.0 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus DAO PF01266.19 KII63637.1 - 2.6e-15 56.1 0.1 2.8e-15 56.1 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 KII63637.1 - 0.0031 16.4 0.1 0.0035 16.2 0.1 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.22 KII63637.1 - 0.004 17.5 1.2 0.0076 16.6 0.5 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KII63637.1 - 0.0083 15.2 0.0 0.0089 15.1 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KII63637.1 - 0.011 15.7 0.2 0.017 15.1 0.1 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 KII63637.1 - 0.042 12.7 0.1 0.055 12.3 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_2 PF07992.9 KII63637.1 - 0.048 13.5 0.0 0.051 13.4 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KII63637.1 - 0.049 12.4 0.1 0.049 12.4 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.12 KII63637.1 - 0.061 12.4 0.0 0.061 12.4 0.0 1.1 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 KII63637.1 - 0.094 12.7 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KII63637.1 - 0.11 12.2 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding DAO PF01266.19 KII63638.1 - 7.8e-09 34.8 0.0 9.6e-09 34.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase CHU_C PF13585.1 KII63638.1 - 0.051 13.4 0.3 0.12 12.3 0.2 1.6 1 1 0 1 1 1 0 C-terminal domain of CHU protein family DUF692 PF05114.8 KII63639.1 - 0.11 11.3 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF692) Syntaxin-6_N PF09177.6 KII63640.1 - 0.0021 18.4 0.2 0.0026 18.1 0.1 1.2 1 0 0 1 1 1 1 Syntaxin 6, N-terminal Prefoldin_2 PF01920.15 KII63640.1 - 0.036 13.8 0.7 0.062 13.0 0.5 1.3 1 0 0 1 1 1 0 Prefoldin subunit DBB PF14545.1 KII63640.1 - 0.039 13.4 0.3 0.12 11.9 0.2 1.7 1 1 1 2 2 2 0 Dof, BCAP, and BANK (DBB) motif, Adeno_PIX PF03955.9 KII63640.1 - 0.063 13.8 0.5 0.079 13.4 0.4 1.2 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) SRC-1 PF08832.5 KII63640.1 - 0.073 13.8 0.7 0.13 12.9 0.5 1.5 1 1 0 1 1 1 0 Steroid receptor coactivator GAS PF13851.1 KII63640.1 - 0.074 12.2 1.6 0.097 11.8 0.9 1.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding CHDCT2 PF08074.6 KII63640.1 - 0.079 12.6 0.4 0.11 12.2 0.3 1.3 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain Prefoldin PF02996.12 KII63640.1 - 0.1 12.2 0.9 0.13 11.8 0.3 1.4 2 0 0 2 2 2 0 Prefoldin subunit Tropomyosin_1 PF12718.2 KII63640.1 - 0.13 12.0 1.8 0.16 11.7 1.0 1.3 1 1 0 1 1 1 0 Tropomyosin like FlxA PF14282.1 KII63640.1 - 0.26 11.2 2.7 0.16 11.8 0.5 1.6 1 1 0 1 1 1 0 FlxA-like protein EIF4E-T PF10477.4 KII63642.1 - 0.062 12.0 0.0 0.069 11.9 0.0 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Dynamin_M PF01031.15 KII63644.1 - 4.1e-56 189.9 6.0 5.4e-39 133.7 1.3 2.8 3 0 0 3 3 3 2 Dynamin central region Dynamin_N PF00350.18 KII63644.1 - 2.8e-42 144.3 0.1 4.6e-42 143.6 0.1 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KII63644.1 - 0.003 17.5 0.3 0.013 15.4 0.2 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase TFIIF_alpha PF05793.7 KII63645.1 - 1.7e-12 46.5 26.2 3.3e-05 22.4 0.3 3.3 2 1 1 3 3 3 3 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1542 PF07564.6 KII63645.1 - 0.98 9.4 7.7 20 5.2 0.1 2.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF1664 PF07889.7 KII63645.1 - 3.4 7.4 6.7 5.2 6.8 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Nol1_Nop2_Fmu PF01189.12 KII63647.1 - 1.8e-17 63.6 0.1 3.3e-17 62.7 0.0 1.4 1 1 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_31 PF13847.1 KII63647.1 - 1.5e-05 24.6 0.1 4.4e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KII63647.1 - 9.2e-05 22.7 0.1 0.00049 20.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 KII63647.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 KII63647.1 - 0.033 13.3 0.0 0.051 12.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_5 PF01795.14 KII63647.1 - 0.052 12.8 0.0 0.08 12.1 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family rve PF00665.21 KII63648.1 - 4.9e-28 97.6 0.0 1.2e-27 96.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII63648.1 - 1.1e-20 73.9 0.1 2.9e-20 72.5 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.5 KII63648.1 - 2.7e-06 26.6 0.1 2.1e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger zf-CCHC PF00098.18 KII63648.1 - 4.4e-05 23.2 3.4 4.4e-05 23.2 2.3 2.8 3 0 0 3 3 3 2 Zinc knuckle RVP PF00077.15 KII63648.1 - 0.00013 21.8 0.1 0.00033 20.5 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease DDE_Tnp_IS240 PF13610.1 KII63648.1 - 0.003 17.5 0.6 0.0077 16.2 0.0 1.9 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII63648.1 - 0.016 14.7 0.0 0.045 13.2 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain zf-CCHC_4 PF14392.1 KII63648.1 - 0.15 11.7 9.4 0.23 11.1 1.1 2.7 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.1 KII63649.1 - 1.9e-12 47.1 0.0 2.3e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII63650.1 - 6.2e-09 35.9 0.1 8.9e-09 35.4 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 KII63650.1 - 2e-05 24.3 0.1 2.8e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.1 KII63650.1 - 2.6e-05 23.7 0.0 0.00069 19.1 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain TrmB PF01978.14 KII63650.1 - 5e-05 22.9 0.1 0.00014 21.4 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB CENP-B_N PF04218.8 KII63650.1 - 0.00015 21.0 0.1 0.00039 19.7 0.0 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.1 KII63650.1 - 0.00015 21.0 0.2 0.0015 17.8 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 KII63650.1 - 0.00023 20.7 0.0 0.00049 19.7 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_28 PF13518.1 KII63650.1 - 0.00038 20.3 0.0 0.016 15.1 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain Fe_dep_repress PF01325.14 KII63650.1 - 0.0014 18.5 0.0 0.0027 17.6 0.0 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_Tnp_Tc3_2 PF01498.13 KII63650.1 - 0.0034 17.4 0.1 0.032 14.2 0.0 2.2 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.1 KII63650.1 - 0.0057 17.4 0.0 0.013 16.3 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.1 KII63650.1 - 0.013 14.6 0.1 0.059 12.5 0.0 2.1 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 Sigma70_r4 PF04545.11 KII63650.1 - 0.025 13.8 0.0 0.064 12.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 Phage_CI_repr PF07022.8 KII63650.1 - 0.027 14.5 0.0 0.034 14.2 0.0 1.2 1 1 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain Sigma70_r4_2 PF08281.7 KII63650.1 - 0.031 13.7 0.0 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_IclR PF09339.5 KII63650.1 - 0.034 13.7 0.0 0.41 10.2 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_30 PF13556.1 KII63650.1 - 0.044 13.3 0.1 2 8.0 0.0 2.7 2 1 1 3 3 3 0 PucR C-terminal helix-turn-helix domain DDE_3 PF13358.1 KII63650.1 - 0.047 13.4 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease B5 PF03484.10 KII63650.1 - 0.049 13.4 0.0 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetase B5 domain HTH_38 PF13936.1 KII63650.1 - 0.062 12.8 0.0 0.31 10.6 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_11 PF08279.7 KII63650.1 - 0.081 12.5 0.6 5.8 6.6 0.1 2.4 2 0 0 2 2 2 0 HTH domain HTH_3 PF01381.17 KII63650.1 - 0.12 12.2 0.1 0.85 9.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix HTH_27 PF13463.1 KII63650.1 - 0.13 12.5 0.1 0.48 10.7 0.0 1.9 2 0 0 2 2 2 0 Winged helix DNA-binding domain DUF1323 PF07037.6 KII63650.1 - 0.15 12.2 0.6 0.21 11.7 0.0 1.6 2 0 0 2 2 1 0 Putative transcription regulator (DUF1323) MFS_1 PF07690.11 KII63651.1 - 5.5e-15 54.9 16.7 6.2e-12 44.9 5.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 KII63651.1 - 0.0003 19.0 0.7 0.0003 19.0 0.5 1.9 2 0 0 2 2 2 1 Transmembrane secretion effector Sugar_tr PF00083.19 KII63651.1 - 0.00092 17.8 6.6 0.00092 17.8 4.6 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter Ribosomal_S13 PF00416.17 KII63652.1 - 4.5 7.7 7.6 1.8 9.0 0.1 3.5 4 0 0 4 4 4 0 Ribosomal protein S13/S18 ChaC PF04752.7 KII63653.1 - 6.3e-55 185.8 0.0 7.1e-55 185.7 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein cwf18 PF08315.7 KII63656.1 - 9.4e-18 64.9 2.5 1.1e-17 64.6 1.7 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor DUF4065 PF13274.1 KII63656.1 - 0.037 14.7 1.4 0.048 14.3 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4065) MRP-L27 PF09809.4 KII63656.1 - 0.087 12.4 1.4 0.52 9.9 0.8 1.9 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L27 WD40 PF00400.27 KII63657.1 - 4.4e-21 73.9 26.0 7.9e-06 25.5 1.4 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat UTP15_C PF09384.5 KII63657.1 - 3.8e-14 52.6 0.2 9e-14 51.3 0.2 1.6 1 1 0 1 1 1 1 UTP15 C terminal Epimerase_Csub PF13950.1 KII63658.1 - 1.3e-21 76.3 0.2 2.2e-21 75.5 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit Epimerase PF01370.16 KII63658.1 - 6.3e-20 71.6 0.1 9.9e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 KII63658.1 - 0.099 11.5 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein Ric8 PF10165.4 KII63659.1 - 0.061 12.1 0.5 0.1 11.3 0.4 1.3 1 0 0 1 1 1 0 Guanine nucleotide exchange factor synembryn DDE_3 PF13358.1 KII63660.1 - 1.7e-24 86.2 0.0 2.3e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease EspG PF06872.6 KII63660.1 - 0.024 13.0 0.0 0.032 12.5 0.0 1.1 1 0 0 1 1 1 0 EspG protein OMS28_porin PF03532.8 KII63661.1 - 0.0032 16.5 0.2 0.0045 16.0 0.2 1.2 1 0 0 1 1 1 1 OMS28 porin Pax7 PF12360.3 KII63662.1 - 0.17 12.1 0.0 0.3 11.3 0.0 1.3 1 0 0 1 1 1 0 Paired box protein 7 DUF1759 PF03564.10 KII63665.1 - 7.3e-22 77.7 0.1 1.1e-21 77.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) DnaJ PF00226.26 KII63666.1 - 4e-25 87.3 1.6 5.9e-25 86.7 1.1 1.3 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.1 KII63666.1 - 0.073 12.4 0.0 0.94 8.9 0.0 2.1 1 1 1 2 2 2 0 A repeated domain in UCH-protein DnaJ_CXXCXGXG PF00684.14 KII63667.1 - 2.2e-11 43.6 11.9 3.4e-11 43.0 8.2 1.4 1 0 0 1 1 1 1 DnaJ central domain CTDII PF01556.13 KII63667.1 - 7.5e-06 25.7 0.3 0.0005 19.9 0.1 2.5 2 0 0 2 2 2 1 DnaJ C terminal domain zf-C4H2 PF10146.4 KII63667.1 - 0.08 12.9 0.3 0.12 12.4 0.2 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein zf-CHY PF05495.7 KII63667.1 - 1.3 9.2 9.2 7.9 6.7 2.7 2.5 1 1 1 2 2 2 0 CHY zinc finger DUF2318 PF10080.4 KII63667.1 - 3.8 7.3 10.7 8.1 6.2 1.3 3.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) Antiterm PF03589.8 KII63667.1 - 6.2 6.9 8.0 5.5e+02 0.7 5.5 3.0 1 1 0 1 1 1 0 Antitermination protein Utp12 PF04003.7 KII63668.1 - 1.5e-06 28.0 0.6 2.1e-06 27.6 0.4 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family DDE_1 PF03184.14 KII63669.1 - 8.1e-05 21.8 0.1 0.00012 21.3 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease NUDIX PF00293.23 KII63670.1 - 4e-20 71.8 0.0 6.2e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Toxin_8 PF07365.7 KII63670.1 - 0.07 13.0 0.3 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 Alpha conotoxin precursor RNase_T PF00929.19 KII63671.1 - 5.3e-11 43.0 0.4 7.9e-11 42.5 0.3 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 KII63671.1 - 0.0042 16.5 1.4 0.19 11.1 0.9 2.2 1 1 0 1 1 1 1 3'-5' exonuclease DUF648 PF04890.8 KII63671.1 - 0.018 14.2 0.1 0.021 14.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF648) Rad21_Rec8_N PF04825.8 KII63671.1 - 0.051 13.5 0.1 0.066 13.1 0.0 1.2 1 0 0 1 1 1 0 N terminus of Rad21 / Rec8 like protein SEA PF01390.15 KII63673.1 - 0.00013 21.5 0.1 0.00032 20.3 0.1 1.6 1 0 0 1 1 1 1 SEA domain Ribosomal_L7Ae PF01248.21 KII63674.1 - 7.3e-11 41.4 0.1 2.2e-10 39.9 0.0 1.7 1 1 1 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DAGK_cat PF00781.19 KII63674.1 - 0.0091 15.4 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain UDPG_MGDP_dh PF00984.14 KII63674.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Vps52 PF04129.7 KII63675.1 - 0.00045 18.8 1.4 0.00068 18.2 0.1 1.9 1 1 0 1 1 1 1 Vps52 / Sac2 family RVT_1 PF00078.22 KII63675.1 - 0.029 13.7 0.1 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2670 PF10875.3 KII63675.1 - 0.037 14.0 0.1 0.1 12.6 0.0 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF2670) Aha1_N PF09229.6 KII63676.1 - 0.1 12.4 0.2 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal KIP1 PF07765.7 KII63676.1 - 0.1 12.4 0.3 0.15 11.9 0.2 1.3 1 0 0 1 1 1 0 KIP1-like protein Viral_DNA_bi PF02236.12 KII63678.1 - 0.13 12.4 0.0 13 6.0 0.0 2.3 2 0 0 2 2 2 0 Viral DNA-binding protein, all alpha domain BLOC1_2 PF10046.4 KII63680.1 - 0.031 14.4 4.6 0.15 12.2 0.8 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3287 PF11690.3 KII63680.1 - 0.046 13.7 0.3 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) XhlA PF10779.4 KII63680.1 - 0.057 13.3 1.2 2.5 8.0 0.2 2.6 2 1 0 2 2 2 0 Haemolysin XhlA Fmp27_WPPW PF10359.4 KII63680.1 - 0.08 11.3 5.5 0.11 10.8 3.1 1.6 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain MULE PF10551.4 KII63681.1 - 0.00062 19.8 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain UPRTase PF14681.1 KII63682.1 - 2.6e-40 137.8 0.0 3.7e-40 137.3 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.13 KII63682.1 - 2.8e-30 105.3 0.1 4.5e-29 101.4 0.0 2.2 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 KII63682.1 - 1.1e-08 35.8 0.1 3.9e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII63682.1 - 8.3e-08 32.6 0.0 2.4e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain CPT PF07931.7 KII63682.1 - 1.6e-07 31.1 0.0 3e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.7 KII63682.1 - 0.00085 18.4 0.0 0.0019 17.3 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin CoaE PF01121.15 KII63682.1 - 0.00088 18.7 0.5 0.014 14.8 0.4 2.3 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.1 KII63682.1 - 0.0012 18.7 0.0 0.0035 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain Pribosyltran PF00156.22 KII63682.1 - 0.0059 16.3 0.0 0.085 12.5 0.0 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain APS_kinase PF01583.15 KII63682.1 - 0.11 12.1 0.1 0.32 10.6 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase MFS_1 PF07690.11 KII63683.1 - 1.4e-25 89.7 31.4 1.3e-19 70.2 10.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily YtpI PF14007.1 KII63683.1 - 4.4 7.3 7.9 11 6.0 0.0 3.5 3 0 0 3 3 3 0 YtpI-like protein Acatn PF13000.2 KII63684.1 - 2.4e-42 145.1 16.4 3.4e-42 144.7 11.4 1.1 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 DUF3561 PF12084.3 KII63684.1 - 0.036 13.9 0.2 0.036 13.9 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3561) MAPEG PF01124.13 KII63684.1 - 0.67 9.5 5.5 0.16 11.5 0.2 2.4 3 0 0 3 3 3 0 MAPEG family CLAMP PF14769.1 KII63686.1 - 0.00028 21.0 0.2 0.086 13.0 0.0 2.4 1 1 1 2 2 2 2 Flagellar C1a complex subunit C1a-32 C1_1 PF00130.17 KII63686.1 - 3 7.6 7.1 0.25 11.1 0.6 2.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) tRNA_lig_kinase PF08303.6 KII63687.1 - 0.029 14.2 0.4 0.029 14.2 0.3 2.2 2 1 0 2 2 2 0 tRNA ligase kinase domain DUF2116 PF09889.4 KII63687.1 - 0.49 10.2 2.9 2.3 8.0 0.6 2.5 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF4220 PF13968.1 KII63688.1 - 0.015 14.4 1.7 0.023 13.8 1.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4220) Ras PF00071.17 KII63694.1 - 9.5e-14 51.1 0.1 1.5e-13 50.4 0.1 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII63694.1 - 8.5e-11 42.3 0.1 1.1e-10 42.0 0.1 1.1 1 0 0 1 1 1 1 Miro-like protein AAA_14 PF13173.1 KII63694.1 - 0.011 15.6 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KII63694.1 - 0.016 15.1 0.1 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Arch_ATPase PF01637.13 KII63694.1 - 0.026 14.2 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase IstB_IS21 PF01695.12 KII63694.1 - 0.032 13.6 0.1 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein KaiC PF06745.8 KII63694.1 - 0.032 13.3 0.1 0.064 12.3 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.1 KII63694.1 - 0.04 14.2 0.2 0.051 13.8 0.1 1.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KII63694.1 - 0.047 13.8 0.1 0.063 13.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KII63694.1 - 0.062 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 KII63694.1 - 0.064 12.4 0.1 0.074 12.2 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 KII63694.1 - 0.069 13.1 1.3 1 9.3 0.9 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_32 PF13654.1 KII63694.1 - 0.084 11.5 0.0 0.092 11.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.7 KII63694.1 - 0.092 12.0 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain DUF2075 PF09848.4 KII63694.1 - 0.12 11.3 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.1 KII63694.1 - 0.42 11.4 1.5 0.48 11.2 1.1 1.4 1 1 0 1 1 1 0 AAA domain Aminotran_1_2 PF00155.16 KII63695.1 - 2.5e-13 49.7 0.0 3.7e-12 45.8 0.0 2.2 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 KII63695.1 - 0.055 11.7 0.0 0.081 11.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme CDT1 PF08839.6 KII63695.1 - 0.064 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 DNA replication factor CDT1 like Armet PF10208.4 KII63695.1 - 0.12 12.0 0.0 4.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding Dimer_Tnp_hAT PF05699.9 KII63698.1 - 2.6e-07 30.1 0.2 3.3e-07 29.8 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region ABC_tran PF00005.22 KII63699.1 - 4.4e-32 111.2 0.0 8.5e-15 55.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter RRM_1 PF00076.17 KII63699.1 - 6.5e-17 60.9 0.3 6.5e-17 60.9 0.2 2.0 2 0 0 2 2 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII63699.1 - 1.4e-13 50.5 0.0 4.2e-13 49.0 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RLI PF04068.10 KII63699.1 - 8.1e-12 44.5 5.0 8.1e-12 44.5 3.5 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI RRM_5 PF13893.1 KII63699.1 - 2.5e-07 30.4 0.9 5e-07 29.4 0.1 2.0 2 0 0 2 2 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_15 PF13175.1 KII63699.1 - 3.1e-07 29.8 3.3 0.00054 19.1 0.1 3.7 2 2 1 3 3 3 1 AAA ATPase domain Fer4 PF00037.22 KII63699.1 - 1.2e-06 27.8 2.7 1.2e-06 27.8 1.9 2.6 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_21 PF13304.1 KII63699.1 - 2.8e-06 27.5 10.9 0.0025 17.8 0.0 4.0 3 2 1 4 4 4 2 AAA domain AAA_22 PF13401.1 KII63699.1 - 2.8e-06 27.4 0.2 0.00023 21.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KII63699.1 - 8.5e-06 25.2 0.0 0.22 11.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain VirE PF05272.6 KII63699.1 - 0.00011 21.7 0.0 0.57 9.6 0.0 2.8 2 0 0 2 2 2 2 Virulence-associated protein E NACHT PF05729.7 KII63699.1 - 0.00013 21.7 0.4 0.016 14.8 0.0 2.5 2 0 0 2 2 2 1 NACHT domain SMC_N PF02463.14 KII63699.1 - 0.00013 21.3 6.5 0.021 14.0 0.1 4.3 2 2 1 3 3 3 1 RecF/RecN/SMC N terminal domain Fer4_7 PF12838.2 KII63699.1 - 0.0003 21.0 5.8 0.0043 17.3 0.1 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain SRP54 PF00448.17 KII63699.1 - 0.00093 18.6 1.1 0.13 11.6 0.0 3.0 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_17 PF13207.1 KII63699.1 - 0.001 19.8 0.3 3.2 8.5 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KII63699.1 - 0.0012 18.8 0.4 0.077 12.9 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 KII63699.1 - 0.0016 18.7 0.9 2.8 8.2 0.0 2.9 2 1 0 2 2 2 2 AAA domain DUF258 PF03193.11 KII63699.1 - 0.0018 17.4 3.9 0.68 9.1 0.0 3.1 3 0 0 3 3 2 2 Protein of unknown function, DUF258 Fer4_6 PF12837.2 KII63699.1 - 0.0021 17.8 11.8 0.003 17.3 1.3 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.1 KII63699.1 - 0.003 17.3 13.5 0.01 15.7 9.4 1.9 1 1 1 2 2 2 1 4Fe-4S dicluster domain AAA_23 PF13476.1 KII63699.1 - 0.0032 17.8 7.2 0.012 15.9 0.4 2.9 3 1 0 3 3 2 1 AAA domain AAA PF00004.24 KII63699.1 - 0.0064 16.6 0.1 2.8 8.1 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 KII63699.1 - 0.0065 16.0 0.1 0.053 13.1 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 KII63699.1 - 0.0079 16.3 0.0 3.5 7.8 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.9 KII63699.1 - 0.008 15.9 0.8 0.11 12.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Miro PF08477.8 KII63699.1 - 0.0086 16.5 0.1 0.47 10.9 0.0 2.6 2 0 0 2 2 2 1 Miro-like protein Fer4_10 PF13237.1 KII63699.1 - 0.009 15.7 1.6 0.009 15.7 1.1 2.1 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_2 PF12797.2 KII63699.1 - 0.011 15.6 2.2 0.011 15.6 1.5 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain MMR_HSR1 PF01926.18 KII63699.1 - 0.012 15.5 0.0 1.2 9.1 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase MobB PF03205.9 KII63699.1 - 0.015 14.9 1.2 1.3 8.7 0.0 2.9 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B Fer4_16 PF13484.1 KII63699.1 - 0.019 15.7 0.2 0.019 15.7 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain AAA_33 PF13671.1 KII63699.1 - 0.029 14.2 0.1 2 8.2 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.1 KII63699.1 - 0.031 14.0 0.0 0.1 12.3 0.0 1.8 2 0 0 2 2 1 0 Part of AAA domain Fer4_9 PF13187.1 KII63699.1 - 0.038 14.2 11.2 0.098 12.9 7.7 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain AAA_28 PF13521.1 KII63699.1 - 0.048 13.6 0.1 3.4 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 KII63699.1 - 0.052 12.9 0.0 6.7 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Nup35_RRM_2 PF14605.1 KII63699.1 - 0.071 12.8 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Fer4_8 PF13183.1 KII63699.1 - 0.12 12.4 7.6 0.19 11.8 0.8 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain Thymidylate_kin PF02223.12 KII63699.1 - 0.12 11.7 0.4 4.8 6.5 0.0 2.8 3 0 0 3 3 2 0 Thymidylate kinase AAA_24 PF13479.1 KII63699.1 - 0.13 11.8 0.8 1.4 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 KII63699.1 - 0.19 11.2 0.0 2.3 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain Fer4_18 PF13746.1 KII63699.1 - 2.8 8.4 8.5 0.4 11.1 2.3 2.2 1 1 0 1 1 1 0 4Fe-4S dicluster domain Myotub-related PF06602.9 KII63701.1 - 4.1e-106 354.7 1.7 5.6e-106 354.2 1.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.1 KII63701.1 - 0.022 14.9 0.0 0.044 14.0 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.15 KII63701.1 - 0.027 14.0 0.3 0.098 12.2 0.1 2.0 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain IQ PF00612.22 KII63703.1 - 0.0039 16.6 0.0 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ldl_recept_a PF00057.13 KII63707.1 - 4.1e-07 29.7 12.0 4.1e-07 29.7 8.3 3.9 3 1 1 4 4 4 2 Low-density lipoprotein receptor domain class A PRY PF13765.1 KII63707.1 - 0.18 11.3 1.3 0.46 10.0 0.2 2.2 2 0 0 2 2 2 0 SPRY-associated domain Pkinase PF00069.20 KII63709.1 - 6.2e-52 176.3 0.1 8.1e-52 175.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII63709.1 - 5.9e-25 87.8 0.0 7.7e-25 87.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII63709.1 - 0.00044 19.2 0.0 0.003 16.5 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 KII63709.1 - 0.0035 16.4 0.0 0.006 15.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 KII63709.1 - 0.0066 16.0 0.9 0.014 14.9 0.6 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 KII63709.1 - 0.0092 15.7 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family FLYWCH PF04500.11 KII63711.1 - 1e-06 28.5 0.7 1.5e-06 28.0 0.5 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain 7tm_2 PF00002.19 KII63713.1 - 0.63 9.0 4.3 0.64 9.0 3.0 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (Secretin family) MMS1_N PF10433.4 KII63716.1 - 5.1e-38 130.4 1.0 1.1e-37 129.4 0.7 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 KII63716.1 - 1e-37 129.9 1.5 1.6e-35 122.7 0.4 3.2 3 0 0 3 3 3 2 CPSF A subunit region DDE_3 PF13358.1 KII63717.1 - 1.1e-07 31.6 0.0 1.7e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.3 KII63717.1 - 2e-05 24.1 0.1 3.7e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Tc3 transposase Sigma70_r4_2 PF08281.7 KII63717.1 - 0.09 12.2 0.1 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Ribosomal_L24e PF01246.15 KII63719.1 - 6.5e-25 86.7 3.3 6.5e-25 86.7 2.3 2.3 2 0 0 2 2 2 1 Ribosomal protein L24e PINIT PF14324.1 KII63720.1 - 0.03 14.4 0.6 0.038 14.0 0.4 1.1 1 0 0 1 1 1 0 PINIT domain Toprim_N PF08275.6 KII63722.1 - 0.064 13.2 0.8 0.4 10.6 0.1 2.0 1 1 1 2 2 2 0 DNA primase catalytic core, N-terminal domain Macscav_rec PF03523.8 KII63722.1 - 0.16 11.7 1.6 0.25 11.1 0.3 1.9 2 0 0 2 2 2 0 Macrophage scavenger receptor RVT_1 PF00078.22 KII63723.1 - 8.6e-05 21.9 1.6 9.7e-05 21.8 0.6 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) CTD_bind PF04818.8 KII63723.1 - 0.021 15.0 0.2 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase II-binding domain. T_Ag_DNA_bind PF02217.11 KII63723.1 - 0.071 13.5 0.6 0.086 13.2 0.4 1.2 1 0 0 1 1 1 0 Origin of replication binding protein GAT PF03127.9 KII63726.1 - 0.1 12.5 0.2 0.2 11.6 0.1 1.5 1 1 0 1 1 1 0 GAT domain DUF4500 PF14937.1 KII63727.1 - 0.094 12.5 0.1 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) Vac14_Fab1_bd PF12755.2 KII63729.1 - 0.039 14.3 0.4 0.046 14.0 0.3 1.3 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region DUF3666 PF12408.3 KII63731.1 - 0.14 11.2 0.0 0.27 10.3 0.0 1.4 1 0 0 1 1 1 0 Ribose-5-phosphate isomerase DUF2009 PF09418.5 KII63732.1 - 0.053 12.2 0.8 0.086 11.6 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2009) DUF2719 PF10891.3 KII63732.1 - 0.067 12.8 0.4 0.2 11.3 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) HTH_Tnp_4 PF13613.1 KII63733.1 - 0.0021 17.5 0.3 6.4 6.4 0.0 3.2 3 0 0 3 3 3 2 Helix-turn-helix of DDE superfamily endonuclease BrkDBD PF09607.5 KII63733.1 - 0.0093 15.5 0.1 0.019 14.5 0.1 1.5 1 0 0 1 1 1 1 Brinker DNA-binding domain HTH_Tnp_IS630 PF01710.11 KII63733.1 - 0.018 14.6 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Transposase HTH_23 PF13384.1 KII63733.1 - 0.019 14.6 0.0 0.05 13.2 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_28 PF13518.1 KII63733.1 - 0.038 13.9 0.0 0.067 13.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Ribosomal_S9 PF00380.14 KII63736.1 - 1.5e-34 118.8 0.9 2e-34 118.4 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Slu7 PF11708.3 KII63737.1 - 3e-67 226.8 6.8 3e-67 226.8 4.7 1.9 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.1 KII63737.1 - 0.14 11.8 1.6 0.37 10.5 1.1 1.7 1 0 0 1 1 1 0 Zinc knuckle CLPTM1 PF05602.7 KII63739.1 - 5.7e-99 331.7 9.5 7.1e-99 331.4 6.6 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) Ribosomal_S10 PF00338.17 KII63740.1 - 8.5e-21 73.6 0.1 1.8e-20 72.5 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Cas_Cas1 PF01867.11 KII63740.1 - 0.031 13.3 0.1 0.066 12.2 0.1 1.5 1 1 1 2 2 2 0 CRISPR associated protein Cas1 Indigoidine_A PF04227.7 KII63742.1 - 0.13 11.4 0.6 0.25 10.5 0.1 1.6 2 0 0 2 2 2 0 Indigoidine synthase A like protein Calici_MSP PF05752.6 KII63742.1 - 0.15 11.6 1.0 0.27 10.8 0.7 1.4 1 0 0 1 1 1 0 Calicivirus minor structural protein zf-UBR PF02207.15 KII63745.1 - 6.9e-16 57.7 12.8 2e-15 56.2 8.9 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) F_actin_bind PF08919.5 KII63745.1 - 0.012 15.3 1.4 0.021 14.5 0.1 2.1 2 0 0 2 2 2 0 F-actin binding Ribos_L4_asso_C PF14374.1 KII63746.1 - 1.1 9.2 4.9 5.7 6.8 3.2 2.2 1 1 0 1 1 1 0 60S ribosomal protein L4 C-terminal domain ACR_tran PF00873.14 KII63748.1 - 4.2e-156 521.0 10.1 4.7e-156 520.9 7.0 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.10 KII63748.1 - 0.27 9.8 5.6 0.051 12.2 0.9 1.9 2 1 1 3 3 3 0 MMPL family GWT1 PF06423.7 KII63750.1 - 0.013 15.6 0.5 0.013 15.6 0.4 1.7 2 0 0 2 2 2 0 GWT1 SlyX PF04102.7 KII63751.1 - 0.0036 17.6 3.7 0.008 16.5 1.2 2.0 2 0 0 2 2 2 1 SlyX DUF148 PF02520.12 KII63751.1 - 0.0071 16.1 3.2 0.013 15.3 2.2 1.4 1 1 0 1 1 1 1 Domain of unknown function DUF148 DUF434 PF04256.7 KII63751.1 - 0.063 12.6 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF434) IFT20 PF14931.1 KII63751.1 - 0.064 13.1 2.4 0.074 12.9 1.6 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 TALPID3 PF15324.1 KII63751.1 - 0.072 10.4 1.8 0.084 10.2 1.3 1.0 1 0 0 1 1 1 0 Hedgehog signalling target DUF1043 PF06295.7 KII63751.1 - 0.19 11.3 2.9 8.1 6.1 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Adeno_PIX PF03955.9 KII63751.1 - 0.2 12.1 2.0 0.32 11.5 0.6 1.7 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) Snf7 PF03357.16 KII63751.1 - 0.24 10.7 5.5 0.37 10.1 1.9 2.0 2 0 0 2 2 2 0 Snf7 DUF948 PF06103.6 KII63751.1 - 0.46 10.3 2.8 8.5 6.3 0.4 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Synaptobrevin PF00957.16 KII63751.1 - 2.9 7.5 7.1 0.32 10.6 1.4 1.8 2 0 0 2 2 2 0 Synaptobrevin Fzo_mitofusin PF04799.8 KII63751.1 - 5.2 6.4 6.3 8.9 5.6 1.6 2.0 1 1 1 2 2 2 0 fzo-like conserved region NodZ PF05830.6 KII63756.1 - 0.00071 18.2 0.1 0.0018 16.9 0.0 1.6 2 0 0 2 2 2 1 Nodulation protein Z (NodZ) HALZ PF02183.13 KII63757.1 - 0.032 13.9 0.0 0.062 13.0 0.0 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF3445 PF11927.3 KII63761.1 - 0.022 14.1 0.2 0.04 13.2 0.1 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3445) Metallophos PF00149.23 KII63763.1 - 3.5e-05 23.2 0.1 4.6e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_transf_17 PF04724.8 KII63765.1 - 0.0017 17.4 0.1 0.002 17.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 17 DDE_3 PF13358.1 KII63768.1 - 1.2e-05 25.0 0.0 1.3e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3610 PF12272.3 KII63768.1 - 0.0005 19.7 0.1 0.00072 19.2 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3610) DUF4573 PF15140.1 KII63769.1 - 1.6e-06 27.8 4.4 1.4e-05 24.7 3.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4573) SelP_N PF04592.9 KII63774.1 - 0.0055 16.1 0.1 0.016 14.5 0.0 1.6 2 0 0 2 2 2 1 Selenoprotein P, N terminal region DDE_3 PF13358.1 KII63775.1 - 8e-10 38.6 0.0 4.6e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HNH_2 PF13391.1 KII63775.1 - 0.096 12.4 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 HNH endonuclease Metallophos PF00149.23 KII63776.1 - 1.7e-05 24.2 1.7 6.4e-05 22.4 1.1 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KII63776.1 - 0.00037 20.3 0.4 0.00062 19.6 0.3 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF4516 PF14990.1 KII63777.1 - 0.4 10.2 2.3 1.7 8.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4516) DUF2339 PF10101.4 KII63778.1 - 0.018 13.3 2.4 0.02 13.2 1.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) P12 PF12669.2 KII63778.1 - 0.99 9.6 5.7 4.9 7.4 0.1 2.3 2 0 0 2 2 2 0 Virus attachment protein p12 family Wzy_C PF04932.10 KII63778.1 - 1.4 8.6 6.3 2 8.1 4.4 1.3 1 1 0 1 1 1 0 O-Antigen ligase TMEM154 PF15102.1 KII63778.1 - 4.9 6.8 5.5 8.1 6.1 0.9 2.0 1 1 1 2 2 2 0 TMEM154 protein family rve PF00665.21 KII63782.1 - 4.3e-17 62.3 0.0 8.4e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII63782.1 - 0.00036 19.9 0.0 0.00075 18.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain CTNNBL PF08216.6 KII63786.1 - 0.025 14.1 1.7 7.6 6.1 0.0 3.2 3 0 0 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear DUF2753 PF10952.3 KII63786.1 - 0.034 14.1 0.2 0.97 9.4 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2753) Rota_NS6 PF04866.7 KII63786.1 - 0.05 13.6 0.0 0.73 9.8 0.0 2.5 2 0 0 2 2 2 0 Rotavirus non-structural protein 6 Ninjurin PF04923.7 KII63789.1 - 0.097 12.4 2.0 0.63 9.7 0.1 2.2 2 0 0 2 2 2 0 Ninjurin Clc-like PF07062.7 KII63789.1 - 0.16 11.1 0.1 0.16 11.1 0.1 1.9 2 0 0 2 2 2 0 Clc-like PMP22_Claudin PF00822.15 KII63789.1 - 0.46 10.1 7.7 2.7 7.6 5.3 2.0 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family DUF4064 PF13273.1 KII63789.1 - 0.93 9.6 13.8 12 6.0 9.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) DUF3671 PF12420.3 KII63789.1 - 1.5 8.8 4.9 2.3 8.2 3.4 1.4 1 1 0 1 1 1 0 Protein of unknown function Sigma_reg_N PF13800.1 KII63789.1 - 1.7 8.7 5.9 3.7 7.6 0.3 2.2 2 0 0 2 2 2 0 Sigma factor regulator N-terminal NADH_dehy_S2_C PF06444.6 KII63789.1 - 2.2 8.6 5.5 3.7 7.9 0.0 2.2 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 C-terminus DUF3975 PF13126.1 KII63789.1 - 2.7 8.2 6.8 3.6 7.8 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3975) Claudin_2 PF13903.1 KII63789.1 - 3 7.4 8.2 0.11 12.1 0.2 1.9 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.6 KII63789.1 - 4.1 6.9 7.4 1.9 8.0 0.2 2.0 2 0 0 2 2 2 0 Amastin surface glycoprotein DUF3040 PF11239.3 KII63789.1 - 9.9 6.2 7.0 3.6 7.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) UPF0233 PF06781.7 KII63790.1 - 0.73 9.4 2.8 2.1 8.0 0.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0233) Cytochrom_B_N PF00033.14 KII63790.1 - 4.6 6.5 6.6 9.5 5.5 4.6 1.6 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB RVT_1 PF00078.22 KII63791.1 - 2.3e-21 76.1 0.4 1.3e-20 73.7 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII63791.1 - 4e-05 23.4 0.0 0.00016 21.5 0.0 2.0 2 0 0 2 2 2 1 Retroviral aspartyl protease DUF4451 PF14616.1 KII63791.1 - 0.024 14.4 0.9 0.057 13.1 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) Asp_protease_2 PF13650.1 KII63791.1 - 0.15 12.6 0.0 0.4 11.2 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease Metallophos PF00149.23 KII63794.1 - 1.5e-05 24.5 3.5 0.044 13.1 0.0 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KII63794.1 - 0.001 18.9 0.0 0.011 15.5 0.0 2.4 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Adeno_E4_ORF3 PF06931.6 KII63794.1 - 0.04 13.9 0.0 13 5.8 0.0 2.3 1 1 1 2 2 2 0 Mastadenovirus E4 ORF3 protein Chlor_dismutase PF06778.7 KII63794.1 - 0.062 13.0 0.0 8.5 6.0 0.0 2.5 2 0 0 2 2 2 0 Chlorite dismutase zf-CDGSH PF09360.5 KII63795.1 - 0.039 13.7 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Iron-binding zinc finger CDGSH type GRAM PF02893.15 KII63796.1 - 1.3e-10 40.6 0.1 2.9e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 GRAM domain DEAD PF00270.24 KII63798.1 - 2.5e-37 127.9 0.0 3.9e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII63798.1 - 4e-26 90.6 0.3 1.5e-25 88.8 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII63798.1 - 6.8e-05 22.7 0.1 0.00022 21.1 0.0 2.0 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 KII63798.1 - 0.0023 17.8 0.0 0.0059 16.5 0.0 1.6 2 0 0 2 2 2 1 Helicase C-terminal domain AAA_19 PF13245.1 KII63798.1 - 0.025 14.3 0.1 0.067 12.9 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_11 PF13086.1 KII63798.1 - 0.027 14.0 0.2 0.46 10.0 0.0 2.4 2 1 1 3 3 3 0 AAA domain DUF1253 PF06862.7 KII63798.1 - 0.035 12.5 0.4 9.4 4.5 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1253) CMS1 PF14617.1 KII63798.1 - 0.072 12.1 0.1 0.26 10.3 0.0 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit SMC_N PF02463.14 KII63798.1 - 0.087 12.0 0.1 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain tRNA-synt_1b PF00579.20 KII63798.1 - 0.096 11.7 0.0 5.4 6.0 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) Guanylate_kin PF00625.16 KII63799.1 - 1.8e-06 27.4 0.0 2.1e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase DUF1289 PF06945.8 KII63799.1 - 0.061 12.7 1.6 0.12 11.8 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) EF-hand_1 PF00036.27 KII63800.1 - 9.1e-14 49.6 5.3 9e-07 27.7 0.7 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KII63800.1 - 5e-12 44.6 3.5 2.3e-05 23.8 0.5 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KII63800.1 - 5.3e-12 45.6 5.3 2e-11 43.8 3.7 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KII63800.1 - 4e-10 39.1 5.9 0.00012 21.6 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KII63800.1 - 2.8e-08 32.7 2.9 4.5e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.4 KII63800.1 - 0.0016 18.4 0.3 0.0042 17.0 0.2 1.7 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KII63800.1 - 0.0041 16.8 3.1 0.87 9.3 0.5 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand TAF1D PF15333.1 KII63800.1 - 0.077 12.7 0.3 0.087 12.5 0.2 1.1 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D EF-hand_10 PF14788.1 KII63800.1 - 0.081 12.6 2.9 0.2 11.3 0.1 2.2 2 0 0 2 2 2 0 EF hand RST PF12174.3 KII63800.1 - 0.088 12.6 0.3 0.25 11.1 0.1 1.7 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain PMBR PF09373.5 KII63800.1 - 0.095 12.6 0.5 1.9 8.5 0.0 2.5 3 0 0 3 3 3 0 Pseudomurein-binding repeat EF-hand_1 PF00036.27 KII63801.1 - 0.0021 17.2 0.7 0.13 11.6 0.1 2.6 2 1 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KII63801.1 - 0.0053 16.5 0.3 0.27 11.2 0.2 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KII63801.1 - 0.013 15.5 0.5 0.061 13.4 0.3 2.1 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.1 KII63801.1 - 0.027 14.0 0.3 0.38 10.4 0.2 2.6 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 KII63801.1 - 0.042 13.2 0.1 0.12 11.7 0.0 1.7 1 0 0 1 1 1 0 EF hand DUF3641 PF12345.3 KII63801.1 - 0.088 12.6 0.5 0.12 12.2 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3641) MIT PF04212.13 KII63805.1 - 2.1e-10 40.2 0.5 4.3e-10 39.3 0.3 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF327 PF03885.8 KII63805.1 - 0.04 13.7 3.0 0.54 10.0 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF327) Use1 PF09753.4 KII63805.1 - 0.056 12.8 0.6 0.097 12.0 0.4 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 RVP PF00077.15 KII63807.1 - 7.5e-06 25.7 0.0 1.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII63807.1 - 0.093 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease PDGLE PF13190.1 KII63808.1 - 0.036 13.7 0.2 0.05 13.2 0.1 1.2 1 0 0 1 1 1 0 PDGLE domain WBP-1 PF11669.3 KII63808.1 - 0.091 12.8 1.2 0.17 12.0 0.8 1.6 1 1 0 1 1 1 0 WW domain-binding protein 1 DUF2668 PF10873.3 KII63808.1 - 0.48 10.5 5.5 0.84 9.7 3.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2668) Shisa PF13908.1 KII63809.1 - 0.047 13.8 1.7 0.065 13.4 1.2 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EGF_2 PF07974.8 KII63810.1 - 0.0012 18.9 6.8 0.0043 17.1 4.7 2.0 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.2 KII63810.1 - 0.17 12.0 3.5 0.56 10.4 2.4 2.0 1 0 0 1 1 1 0 Human growth factor-like EGF zf-RING-like PF08746.6 KII63810.1 - 0.18 11.8 2.9 2.2 8.3 2.0 2.6 1 1 0 1 1 1 0 RING-like domain Integrin_beta PF00362.13 KII63811.1 - 7.6e-29 100.8 0.2 1.1e-28 100.2 0.1 1.3 1 0 0 1 1 1 1 Integrin, beta chain Integrin_beta PF00362.13 KII63812.1 - 2.4e-06 26.7 0.0 2.5e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Integrin, beta chain EGF_2 PF07974.8 KII63814.1 - 0.0087 16.2 47.4 0.0088 16.1 11.0 3.8 2 2 1 3 3 3 2 EGF-like domain Integrin_beta PF00362.13 KII63816.1 - 0.00028 19.9 0.6 0.017 14.0 0.0 2.0 1 1 1 2 2 2 2 Integrin, beta chain Integrin_beta PF00362.13 KII63819.1 - 2.4e-17 62.9 0.0 2.3e-08 33.3 0.0 2.0 1 1 1 2 2 2 2 Integrin, beta chain PSI PF01437.20 KII63819.1 - 0.052 13.7 0.3 0.098 12.8 0.2 1.5 1 0 0 1 1 1 0 Plexin repeat EGF_2 PF07974.8 KII63820.1 - 1e-06 28.7 79.4 6.2e-05 23.0 11.2 5.8 4 1 1 5 5 5 4 EGF-like domain Elongin_A PF06881.6 KII63821.1 - 0.098 13.0 0.9 0.19 12.1 0.6 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Neur_chan_memb PF02932.11 KII63824.1 - 0.11 12.3 0.8 0.14 12.0 0.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HI0933_like PF03486.9 KII63824.1 - 0.97 7.8 6.1 1.1 7.6 4.2 1.2 1 0 0 1 1 1 0 HI0933-like protein 2OG-FeII_Oxy_2 PF13532.1 KII63824.1 - 2 8.2 6.0 2.4 7.9 4.1 1.1 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily TMEM154 PF15102.1 KII63824.1 - 2.8 7.6 6.3 1.1 9.0 1.9 2.1 1 1 0 1 1 1 0 TMEM154 protein family PAT1 PF09770.4 KII63824.1 - 6 4.9 35.6 6.7 4.8 24.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tox-PLDMTX PF15645.1 KII63826.1 - 0.19 11.8 2.6 0.16 12.0 0.8 1.6 1 1 0 2 2 2 0 Dermonecrotoxin of the Papain-like fold DDE_Tnp_IS1595 PF12762.2 KII63827.1 - 1.1e-19 70.7 0.0 1.4e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain SNAP PF14938.1 KII63828.1 - 3.3e-06 26.4 0.9 3.3e-06 26.4 0.7 1.6 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP zf-DBF PF07535.7 KII63828.1 - 0.043 13.5 1.1 0.078 12.6 0.4 1.8 1 1 0 1 1 1 0 DBF zinc finger HTH_23 PF13384.1 KII63830.1 - 7.3e-06 25.4 0.0 1.6e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII63830.1 - 0.00024 21.0 0.0 0.00039 20.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.13 KII63830.1 - 0.0028 17.3 0.0 0.0041 16.8 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.1 KII63830.1 - 0.0065 16.6 0.1 0.012 15.7 0.1 1.4 1 1 0 1 1 1 1 Winged helix-turn helix Peptidase_C1 PF00112.18 KII63831.1 - 4.6e-73 245.7 2.0 5.8e-73 245.3 1.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII63831.1 - 6.1e-10 39.2 1.3 6.1e-10 39.2 0.9 2.2 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) DUF4093 PF13331.1 KII63831.1 - 0.0036 17.4 0.4 0.41 10.8 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4093) Peptidase_C1_2 PF03051.10 KII63831.1 - 0.048 12.1 0.3 0.081 11.4 0.2 1.2 1 0 0 1 1 1 0 Peptidase C1-like family Peptidase_C1 PF00112.18 KII63832.1 - 2.9e-67 226.7 6.6 3.7e-67 226.4 4.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII63832.1 - 7.9e-10 38.8 1.0 7.9e-10 38.8 0.7 1.9 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C39_2 PF13529.1 KII63832.1 - 0.00094 19.5 0.6 0.0027 18.0 0.2 2.0 2 0 0 2 2 2 1 Peptidase_C39 like family Peptidase_C1_2 PF03051.10 KII63832.1 - 0.0016 17.0 0.7 0.0028 16.2 0.5 1.3 1 0 0 1 1 1 1 Peptidase C1-like family FBP PF07299.6 KII63832.1 - 0.022 14.1 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 Fibronectin-binding protein (FBP) RVT_1 PF00078.22 KII63833.1 - 2e-27 95.9 0.2 5.1e-27 94.6 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII63833.1 - 8e-25 87.2 0.0 2.2e-24 85.8 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII63833.1 - 2.5e-07 30.5 1.5 1.5e-06 28.0 0.1 3.0 4 0 0 4 4 4 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII63833.1 - 9e-05 22.2 1.3 9e-05 22.2 0.9 2.2 2 0 0 2 2 2 1 Zinc knuckle Retrotrans_gag PF03732.12 KII63833.1 - 0.0002 21.3 0.1 0.00077 19.4 0.1 2.0 1 0 0 1 1 1 1 Retrotransposon gag protein rve_3 PF13683.1 KII63833.1 - 0.00063 19.2 1.8 0.0011 18.4 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain Asp_protease_2 PF13650.1 KII63833.1 - 0.00088 19.7 0.0 0.0024 18.3 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII63833.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII63833.1 - 0.005 16.3 0.2 0.013 15.0 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease Spuma_A9PTase PF03539.9 KII63833.1 - 0.012 15.5 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Tetraspannin PF00335.15 KII63834.1 - 2.6e-12 46.5 16.1 3.1e-12 46.2 11.1 1.0 1 0 0 1 1 1 1 Tetraspanin family Baculo_p47 PF05112.7 KII63836.1 - 0.029 13.7 0.2 0.033 13.5 0.2 1.0 1 0 0 1 1 1 0 Baculovirus P47 protein Radical_SAM PF04055.16 KII63838.1 - 5.8e-14 52.5 0.2 2e-13 50.8 0.1 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 KII63838.1 - 1.6e-07 31.2 0.4 4.9e-07 29.6 0.3 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KII63838.1 - 0.089 12.9 0.3 0.34 11.0 0.1 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain zf-C2H2_4 PF13894.1 KII63839.1 - 1.8e-05 24.7 9.4 0.04 14.2 1.3 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KII63839.1 - 0.00024 21.2 14.0 0.07 13.4 1.6 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.2 KII63839.1 - 0.0084 16.2 0.5 0.0084 16.2 0.4 3.0 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 KII63839.1 - 0.075 12.9 0.9 0.075 12.9 0.6 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.10 KII63839.1 - 0.089 12.5 0.9 0.22 11.2 0.6 1.7 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_2 PF12756.2 KII63839.1 - 0.19 11.8 4.2 0.75 9.9 2.9 1.9 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.1 KII63839.1 - 0.39 11.0 0.1 0.39 11.0 0.1 4.5 5 0 0 5 5 5 0 Zinc-finger double domain Ribosomal_L30 PF00327.15 KII63840.1 - 3.5e-20 71.3 3.4 4.3e-20 71.0 1.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 KII63840.1 - 1.9e-15 56.6 15.5 3.4e-15 55.8 10.8 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Snf7 PF03357.16 KII63841.1 - 4.3e-32 110.8 14.4 5.2e-32 110.5 10.0 1.1 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.7 KII63841.1 - 0.00067 19.8 3.1 0.012 15.7 0.1 2.6 3 0 0 3 3 2 1 Nucleopolyhedrovirus P10 protein DUF2312 PF10073.4 KII63841.1 - 0.0096 15.2 1.5 0.0096 15.2 1.0 2.7 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2312) Eaf7 PF07904.8 KII63841.1 - 0.017 15.1 3.4 0.017 15.1 2.4 2.7 1 1 0 2 2 2 0 Chromatin modification-related protein EAF7 Sugarporin_N PF11471.3 KII63841.1 - 0.043 13.4 0.1 0.043 13.4 0.1 2.1 3 0 0 3 3 1 0 Maltoporin periplasmic N-terminal extension Vac_Fusion PF02346.11 KII63841.1 - 0.055 12.8 2.3 6 6.3 0.0 2.9 3 0 0 3 3 3 0 Chordopoxvirus fusion protein DUF4140 PF13600.1 KII63841.1 - 0.094 13.1 1.6 0.67 10.4 0.2 2.5 2 2 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Complex1_LYR_2 PF13233.1 KII63841.1 - 0.12 12.8 1.7 0.23 11.9 1.1 1.6 1 1 0 1 1 1 0 Complex1_LYR-like SIM_C PF06621.7 KII63841.1 - 0.14 11.7 1.8 0.22 11.0 1.3 1.4 1 1 0 1 1 1 0 Single-minded protein C-terminus GvpK PF05121.7 KII63841.1 - 0.25 11.2 3.3 2.2 8.1 0.6 2.4 2 0 0 2 2 2 0 Gas vesicle protein K TBPIP PF07106.8 KII63841.1 - 0.29 10.6 12.8 0.43 10.1 3.0 2.5 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FlaC_arch PF05377.6 KII63841.1 - 0.43 10.5 3.4 14 5.6 0.1 2.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Blo-t-5 PF11642.3 KII63841.1 - 0.65 9.7 6.2 3.8 7.2 1.4 2.3 2 0 0 2 2 2 0 Mite allergen Blo t 5 DUF677 PF05055.7 KII63841.1 - 0.66 8.5 7.3 0.97 8.0 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF677) Fib_alpha PF08702.5 KII63841.1 - 0.8 9.8 9.9 1.5 8.9 5.8 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family YlbD_coat PF14071.1 KII63841.1 - 1.2 9.1 8.3 0.82 9.7 1.3 2.4 1 1 0 2 2 2 0 Putative coat protein DUF4446 PF14584.1 KII63841.1 - 1.5 8.6 8.8 7.1 6.4 2.2 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) DUF2802 PF10975.3 KII63841.1 - 2.3 8.0 8.4 0.27 11.0 1.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2802) V_ATPase_I PF01496.14 KII63841.1 - 2.4 5.8 10.2 2.8 5.7 6.5 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family YlqD PF11068.3 KII63841.1 - 2.6 8.0 13.5 7.2 6.6 6.1 2.3 1 1 1 2 2 2 0 YlqD protein Seryl_tRNA_N PF02403.17 KII63841.1 - 2.7 8.0 14.5 8 6.5 3.4 2.8 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Tnp_P_element PF12017.3 KII63841.1 - 3.3 6.8 8.6 1.4 8.0 1.8 2.4 1 1 2 3 3 3 0 Transposase protein SLIDE PF09111.5 KII63841.1 - 3.4 7.4 8.0 1.8 8.3 2.6 2.1 1 1 1 2 2 2 0 SLIDE Fzo_mitofusin PF04799.8 KII63841.1 - 4.2 6.7 8.2 3.4 7.0 1.3 2.6 2 1 1 3 3 3 0 fzo-like conserved region DUF3373 PF11853.3 KII63841.1 - 4.8 5.5 11.7 18 3.7 8.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) Syntaxin PF00804.20 KII63841.1 - 5.3 7.2 10.2 72 3.6 7.1 2.4 1 1 0 1 1 1 0 Syntaxin Mnd1 PF03962.10 KII63841.1 - 6.7 6.3 12.8 17 5.0 8.8 1.7 1 1 0 1 1 1 0 Mnd1 family IncA PF04156.9 KII63841.1 - 8 5.9 9.6 4 6.9 4.5 1.9 1 1 0 1 1 1 0 IncA protein DUF3050 PF11251.3 KII63842.1 - 0.026 13.7 0.1 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3050) DDE_Tnp_IS1595 PF12762.2 KII63844.1 - 2.3e-16 59.9 0.1 2.6e-16 59.8 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII63844.1 - 0.025 13.8 0.0 0.027 13.6 0.0 1.0 1 0 0 1 1 1 0 Transposase IS66 family SPATA24 PF15175.1 KII63845.1 - 0.76 9.4 7.0 3.3 7.3 1.3 2.3 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 HTH_45 PF14947.1 KII63847.1 - 0.084 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DDE_Tnp_IS1595 PF12762.2 KII63848.1 - 2.2e-05 24.3 0.2 3.1e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain RmlD_sub_bind PF04321.12 KII63849.1 - 2.2e-07 30.0 0.0 2.7e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 KII63849.1 - 6.6e-06 25.7 0.0 9.6e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2012 PF09430.5 KII63850.1 - 1.9e-15 56.7 0.4 8.4e-15 54.6 0.3 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.1 KII63850.1 - 0.0052 16.8 0.0 0.0083 16.1 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Aldedh PF00171.17 KII63851.1 - 3.1e-140 467.5 0.0 3.6e-140 467.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family HTH_23 PF13384.1 KII63854.1 - 3.8e-07 29.5 0.1 0.00075 19.0 0.0 2.5 2 0 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII63854.1 - 9.2e-06 25.5 0.0 0.008 16.1 0.0 2.5 2 0 0 2 2 2 2 Helix-turn-helix domain CENP-B_N PF04218.8 KII63854.1 - 1.9e-05 23.9 0.0 0.013 14.8 0.0 2.3 2 0 0 2 2 2 2 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.1 KII63854.1 - 2.2e-05 24.5 0.0 3.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_33 PF13592.1 KII63854.1 - 8.9e-05 21.9 0.0 0.00016 21.1 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII63854.1 - 0.001 19.0 0.1 0.0033 17.4 0.0 1.8 2 0 0 2 2 2 1 Transposase PAX PF00292.13 KII63854.1 - 0.005 16.5 0.1 0.0099 15.5 0.1 1.5 1 1 0 1 1 1 1 'Paired box' domain HTH_Tnp_ISL3 PF13542.1 KII63854.1 - 0.044 12.9 0.3 1.2 8.4 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 TrmB PF01978.14 KII63854.1 - 0.07 12.8 0.1 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Carot_N PF09150.5 KII63854.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal PSS PF03034.10 KII63855.1 - 2.6e-27 95.9 2.9 3.6e-27 95.4 2.0 1.2 1 0 0 1 1 1 1 Phosphatidyl serine synthase Bac_export_1 PF01311.15 KII63855.1 - 0.03 13.6 0.4 0.03 13.6 0.3 1.5 2 0 0 2 2 2 0 Bacterial export proteins, family 1 Amidase PF01425.16 KII63857.1 - 1.9e-09 36.9 0.0 2e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Amidase His_Phos_2 PF00328.17 KII63858.1 - 2.5e-06 27.0 0.0 3.2e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DDE_3 PF13358.1 KII63859.1 - 5.9e-14 52.0 0.0 7.2e-14 51.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease BAH PF01426.13 KII63859.1 - 0.032 13.9 0.0 0.042 13.6 0.0 1.2 1 0 0 1 1 1 0 BAH domain DUF2259 PF10016.4 KII63861.1 - 0.087 12.5 0.2 3.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Predicted secreted protein (DUF2259) CLU_N PF15044.1 KII63861.1 - 0.21 11.7 0.3 0.21 11.7 0.2 3.1 4 0 0 4 4 4 0 Mitochondrial function, CLU-N-term DUF1132 PF06575.7 KII63861.1 - 0.52 10.6 7.6 0.26 11.6 2.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1132) RPM2 PF08579.6 KII63862.1 - 0.48 10.5 7.0 1.7 8.7 0.2 3.1 3 0 0 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) Actin PF00022.14 KII63863.1 - 2.3e-15 55.9 0.0 3.4e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Actin Methylase_S PF01420.14 KII63863.1 - 0.032 14.2 0.2 0.038 13.9 0.2 1.4 1 0 0 1 1 1 0 Type I restriction modification DNA specificity domain EF-hand_5 PF13202.1 KII63864.1 - 2.6e-05 23.3 0.1 8.8e-05 21.6 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KII63864.1 - 0.00072 18.6 0.1 0.003 16.7 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KII63864.1 - 0.0011 19.0 0.2 0.0015 18.5 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KII63864.1 - 0.0062 16.1 0.8 0.17 11.5 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 KII63864.1 - 0.011 15.5 1.1 0.028 14.2 0.0 2.4 3 0 0 3 3 3 0 EF-hand domain Stap_Strp_tox_C PF02876.12 KII63864.1 - 0.038 14.1 1.0 0.049 13.8 0.7 1.2 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Gal-3-0_sulfotr PF06990.6 KII63866.1 - 3.9e-17 62.0 7.0 9.9e-16 57.3 4.9 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase DDE_Tnp_IS1595 PF12762.2 KII63867.1 - 0.026 14.3 0.0 0.029 14.2 0.0 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain DUF1074 PF06382.6 KII63868.1 - 0.073 13.0 0.1 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1074) BIR PF00653.16 KII63870.1 - 0.00063 20.1 6.1 0.3 11.5 0.4 2.3 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain DUF2809 PF10990.3 KII63870.1 - 0.013 15.9 0.0 7.6 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2809) Erv26 PF04148.8 KII63870.1 - 0.069 12.5 0.9 8.2 5.7 0.1 2.1 2 0 0 2 2 2 0 Transmembrane adaptor Erv26 LOH1CR12 PF10158.4 KII63870.1 - 0.093 12.5 0.1 12 5.6 0.0 2.1 2 0 0 2 2 2 0 Tumour suppressor protein Fer4_9 PF13187.1 KII63870.1 - 0.25 11.6 5.3 4 7.7 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Oxidored-like PF09791.4 KII63870.1 - 0.26 10.7 6.8 4.1 6.9 0.5 2.4 2 0 0 2 2 2 0 Oxidoreductase-like protein, N-terminal Kelch_6 PF13964.1 KII63873.1 - 1.1e-14 53.8 6.5 4.9e-06 26.4 0.2 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII63873.1 - 6.2e-12 45.2 1.8 0.00031 20.6 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII63873.1 - 1.3e-11 44.0 1.8 0.00019 21.1 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII63873.1 - 1.2e-10 41.2 3.5 0.00026 21.0 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII63873.1 - 4.4e-07 29.3 3.4 0.0023 17.4 0.1 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 KII63873.1 - 0.0002 20.9 3.1 3.6 7.5 0.1 3.4 3 0 0 3 3 3 3 Kelch motif rve PF00665.21 KII63874.1 - 1.5e-21 76.7 0.1 2.2e-21 76.1 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII63874.1 - 5e-05 22.7 0.0 0.00012 21.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII63874.1 - 0.00014 21.6 0.1 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Nepo_coat_N PF03689.10 KII63874.1 - 0.011 15.4 0.1 0.092 12.4 0.0 2.3 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain DUF1796 PF08795.5 KII63874.1 - 0.059 13.0 0.1 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Kelch_6 PF13964.1 KII63875.1 - 2.9e-29 99.9 11.4 1e-05 25.4 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KII63875.1 - 1.6e-25 88.4 8.8 1.4e-06 27.7 0.0 6.2 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII63875.1 - 2.1e-23 81.8 11.8 4.8e-05 23.0 0.1 6.5 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII63875.1 - 4.4e-22 77.6 7.8 6.2e-05 23.0 0.1 7.1 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_2 PF07646.10 KII63875.1 - 2.3e-19 68.3 3.8 1.4e-05 24.6 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.1 KII63875.1 - 9.7e-12 44.5 8.3 0.021 14.7 0.0 6.4 7 0 0 7 7 7 4 Kelch motif Kelch_6 PF13964.1 KII63876.1 - 3.8e-14 52.1 8.8 0.051 13.7 0.1 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII63876.1 - 1e-08 34.8 2.1 0.028 14.1 0.0 5.5 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII63876.1 - 3.1e-07 29.8 13.1 0.022 14.3 0.1 7.0 7 1 0 7 7 7 2 Kelch motif Kelch_5 PF13854.1 KII63876.1 - 0.002 18.0 0.0 12 5.9 0.0 4.0 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.1 KII63876.1 - 0.0028 17.7 0.0 8.4 6.6 0.0 4.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII63876.1 - 0.17 11.6 7.6 18 5.2 0.0 5.2 6 0 0 6 6 6 0 Kelch motif Kelch_6 PF13964.1 KII63878.1 - 3.3e-23 80.8 6.0 4.9e-07 29.6 0.2 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII63878.1 - 3.6e-17 61.6 3.5 4.3e-07 29.3 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII63878.1 - 1.9e-14 53.3 1.7 2.1e-05 24.5 0.1 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII63878.1 - 8.5e-14 51.0 6.7 6.2e-05 22.6 0.1 3.4 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII63878.1 - 7.6e-08 31.8 6.0 0.051 13.3 0.1 4.1 3 2 1 4 4 4 3 Kelch motif Kelch_5 PF13854.1 KII63878.1 - 5.1e-07 29.5 5.0 0.18 11.7 0.1 3.5 3 1 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 KII63879.1 - 0.00076 19.5 0.2 0.29 11.4 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII63879.1 - 0.0016 18.1 1.4 0.023 14.4 0.4 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.1 KII63879.1 - 0.0026 17.8 0.0 0.013 15.6 0.0 2.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII63881.1 - 1.1e-26 91.8 9.3 3e-08 33.4 0.3 4.2 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.20 KII63881.1 - 2.2e-24 84.7 7.7 2.1e-07 30.3 0.0 4.2 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.1 KII63881.1 - 1e-22 79.5 5.4 8.4e-06 25.4 0.0 4.4 3 1 1 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.1 KII63881.1 - 9.2e-19 67.0 3.5 5e-06 26.5 0.1 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII63881.1 - 1.8e-14 53.3 8.2 2.9e-05 23.8 0.2 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 KII63881.1 - 1.7e-10 40.2 7.9 0.0012 18.5 0.1 4.5 4 1 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 KII63883.1 - 0.0039 17.2 0.0 0.01 15.9 0.0 1.7 1 0 0 1 1 1 1 Kelch motif DnaB_2 PF07261.6 KII63884.1 - 0.017 14.6 0.1 0.037 13.6 0.1 1.5 1 0 0 1 1 1 0 Replication initiation and membrane attachment Y_phosphatase2 PF03162.8 KII63885.1 - 0.011 15.0 0.1 0.021 14.2 0.0 1.4 2 0 0 2 2 2 0 Tyrosine phosphatase family UvrD-helicase PF00580.16 KII63886.1 - 0.14 11.4 1.0 0.25 10.6 0.7 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain CLTH PF10607.4 KII63887.1 - 0.099 12.3 1.5 0.19 11.3 1.0 1.5 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DUF1548 PF07579.6 KII63888.1 - 0.04 14.0 0.5 0.14 12.3 0.0 2.0 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1548) POC1 PF10450.4 KII63888.1 - 0.043 12.5 2.5 0.071 11.8 1.0 2.1 2 1 0 2 2 2 0 POC1 chaperone YppF PF14178.1 KII63890.1 - 0.044 13.2 0.4 0.1 12.1 0.3 1.6 1 0 0 1 1 1 0 YppF-like protein Pkinase_Tyr PF07714.12 KII63892.1 - 1.1e-27 96.8 0.4 5.4e-26 91.2 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 KII63892.1 - 6.4e-25 87.7 1.2 3.4e-23 82.1 0.1 2.2 1 1 1 2 2 2 2 Protein kinase domain Bromodomain PF00439.20 KII63893.1 - 3.8e-26 90.8 4.2 2.2e-15 56.3 0.1 5.3 5 0 0 5 5 5 3 Bromodomain BAH PF01426.13 KII63894.1 - 0.00016 21.4 4.6 0.14 11.8 0.3 2.3 2 0 0 2 2 2 2 BAH domain NAD_binding_5 PF07994.7 KII63896.1 - 8.7e-89 297.9 0.0 1e-88 297.6 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 KII63896.1 - 5e-42 142.2 0.5 9.6e-42 141.3 0.1 1.8 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase Met_10 PF02475.11 KII63896.1 - 0.043 13.3 0.1 0.091 12.3 0.1 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Radical_SAM PF04055.16 KII63899.1 - 2.7e-16 60.1 0.0 3.7e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily zf-BED PF02892.10 KII63900.1 - 0.0028 17.3 1.8 0.0056 16.4 1.2 1.6 1 0 0 1 1 1 1 BED zinc finger zf-UBP PF02148.14 KII63900.1 - 0.052 13.6 4.1 0.097 12.7 1.3 2.1 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DUF3602 PF12223.3 KII63900.1 - 0.084 13.2 0.1 0.21 11.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3602) DUF1777 PF08648.7 KII63902.1 - 0.13 11.9 2.2 0.18 11.5 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Kelch_6 PF13964.1 KII63903.1 - 2.7e-12 46.2 3.8 1.3e-05 25.1 0.1 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.1 KII63903.1 - 0.00024 21.1 0.2 0.0028 17.7 0.1 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.20 KII63903.1 - 0.042 13.4 13.9 0.067 12.7 1.3 4.6 4 1 0 4 4 4 0 Kelch motif Kelch_4 PF13418.1 KII63903.1 - 0.37 10.6 10.4 3.4 7.5 0.0 4.4 5 0 0 5 5 5 0 Galactose oxidase, central domain Kelch_6 PF13964.1 KII63906.1 - 6.9e-15 54.4 3.4 9.1e-06 25.6 0.0 4.2 2 2 2 4 4 4 3 Kelch motif Kelch_3 PF13415.1 KII63906.1 - 2.4e-12 46.6 0.2 1.4e-05 25.1 0.0 3.9 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII63906.1 - 1.6e-11 43.7 4.0 0.001 18.8 0.1 4.5 3 1 2 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII63906.1 - 2e-08 33.6 6.1 0.00064 19.2 0.0 4.5 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.1 KII63906.1 - 0.15 12.0 3.8 1.8 8.5 0.0 3.7 4 0 0 4 4 4 0 Kelch motif FAD_binding_5 PF00941.16 KII63907.1 - 0.056 12.8 0.0 0.056 12.8 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain in molybdopterin dehydrogenase AAA_12 PF13087.1 KII63909.1 - 1.1e-41 142.3 0.0 1.3e-41 142.2 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 KII63909.1 - 0.013 15.6 0.0 0.025 14.7 0.0 1.4 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain IU_nuc_hydro PF01156.14 KII63911.1 - 4.8e-31 108.1 0.0 5.9e-31 107.8 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase SMC_N PF02463.14 KII63914.1 - 1.1e-29 103.2 1.6 1.2e-27 96.6 1.3 3.1 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KII63914.1 - 2.4e-27 95.2 0.0 1.4e-26 92.8 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain SbcCD_C PF13558.1 KII63914.1 - 0.0002 21.2 0.0 0.00047 20.0 0.0 1.6 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ATG16 PF08614.6 KII63914.1 - 0.0066 16.3 7.9 0.0066 16.3 5.5 6.6 5 2 0 5 5 5 2 Autophagy protein 16 (ATG16) KH_5 PF13184.1 KII63914.1 - 1.1 9.1 6.6 0.15 11.9 0.3 2.8 3 0 0 3 3 3 0 NusA-like KH domain SMC_N PF02463.14 KII63915.1 - 5.4e-25 87.9 0.0 6e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KII63915.1 - 1.2e-12 48.5 0.0 1.3e-12 48.5 0.0 1.0 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KII63915.1 - 8.2e-09 35.8 0.0 8.9e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KII63915.1 - 1.7e-07 30.6 0.0 2.1e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 KII63915.1 - 8.6e-06 25.0 0.0 9.5e-06 24.9 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.22 KII63915.1 - 0.00037 20.7 0.0 0.00042 20.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter DUF2813 PF11398.3 KII63915.1 - 0.0014 17.8 0.0 0.0014 17.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2813) AAA_16 PF13191.1 KII63915.1 - 0.0026 17.7 0.0 0.0026 17.7 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.17 KII63915.1 - 0.0073 16.4 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 RNA helicase MobB PF03205.9 KII63915.1 - 0.024 14.3 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 KII63915.1 - 0.025 14.5 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.1 KII63915.1 - 0.05 14.4 0.0 0.089 13.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KII63915.1 - 0.055 12.6 0.0 0.063 12.4 0.0 1.1 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_13 PF13166.1 KII63915.1 - 0.061 11.7 0.0 0.061 11.7 0.0 1.0 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KII63915.1 - 0.07 12.5 0.0 0.084 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KII63915.1 - 0.079 12.1 0.0 0.094 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 KII63915.1 - 0.084 12.2 0.1 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain AAA_33 PF13671.1 KII63915.1 - 0.095 12.5 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 KII63915.1 - 0.1 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 KII63915.1 - 0.11 12.0 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 KII63915.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_22 PF13401.1 KII63915.1 - 0.12 12.5 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KII63915.1 - 0.12 11.9 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 NACHT domain Pkinase PF00069.20 KII63916.1 - 4.8e-55 186.5 0.0 6.2e-55 186.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII63916.1 - 3.3e-27 95.1 0.0 4.2e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII63916.1 - 0.0074 15.2 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.15 KII63916.1 - 0.012 15.1 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.18 KII63916.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 KII63916.1 - 0.034 13.2 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Reprolysin_2 PF13574.1 KII63917.1 - 0.00065 19.8 2.8 0.0054 16.8 0.4 2.2 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 KII63917.1 - 0.079 12.4 4.5 0.31 10.5 0.3 2.2 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like zf-UBR PF02207.15 KII63918.1 - 1.8e-11 43.5 15.9 3.6e-11 42.6 11.0 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Glyco_hydro_2_C PF02836.12 KII63918.1 - 0.082 11.7 0.0 0.55 9.0 0.0 2.0 2 0 0 2 2 2 0 Glycosyl hydrolases family 2, TIM barrel domain rve PF00665.21 KII63920.1 - 2.7e-20 72.6 0.0 4.1e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain NSs PF11073.3 KII63920.1 - 0.025 13.8 0.1 6.6 5.9 0.0 2.4 2 1 1 3 3 3 0 Rift valley fever virus non structural protein (NSs) like rve_3 PF13683.1 KII63920.1 - 0.07 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Stirrup PF09061.1 KII63920.1 - 0.1 12.4 0.4 0.3 10.9 0.1 1.9 2 0 0 2 2 2 0 Stirrup zf-UBR PF02207.15 KII63924.1 - 1.9e-13 49.9 7.9 3.2e-13 49.2 5.5 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Stress-antifung PF01657.12 KII63924.1 - 0.1 12.9 1.3 0.16 12.3 0.7 1.5 1 1 0 1 1 1 0 Salt stress response/antifungal DUF4428 PF14471.1 KII63924.1 - 0.25 11.1 2.3 4.3 7.1 1.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) zf-B_box PF00643.19 KII63924.1 - 1.6 8.6 10.6 0.41 10.5 2.9 3.1 2 1 1 3 3 3 0 B-box zinc finger Laminin_EGF PF00053.19 KII63924.1 - 3.7 7.5 7.4 0.13 12.2 0.8 1.8 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) Nop14 PF04147.7 KII63925.1 - 7 4.4 8.1 7.8 4.2 5.6 1.1 1 0 0 1 1 1 0 Nop14-like family HTH_32 PF13565.1 KII63926.1 - 0.00084 20.0 0.0 0.0015 19.2 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 KII63926.1 - 0.0029 17.7 0.0 0.0096 16.0 0.0 1.7 1 1 1 2 2 2 1 Winged helix-turn helix Gcd10p PF04189.8 KII63928.1 - 1e-35 123.3 0.9 2.2e-35 122.2 0.6 1.5 1 1 0 1 1 1 1 Gcd10p family YlqD PF11068.3 KII63928.1 - 0.054 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 YlqD protein Serpin PF00079.15 KII63930.1 - 1.6e-49 169.0 1.5 2e-49 168.7 1.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) EGF_2 PF07974.8 KII63931.1 - 0.00053 20.0 4.8 0.00053 20.0 3.3 4.7 2 2 2 4 4 4 2 EGF-like domain EGF PF00008.22 KII63931.1 - 0.001 18.9 4.8 0.001 18.9 3.3 4.7 4 0 0 4 4 4 2 EGF-like domain Ran-binding PF05508.6 KII63932.1 - 0.00079 18.4 0.4 0.0013 17.6 0.3 1.2 1 0 0 1 1 1 1 RanGTP-binding protein ATP-synt_F6 PF05511.6 KII63932.1 - 0.078 12.8 0.4 1.4 8.8 0.4 3.0 2 1 0 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 DUF4290 PF14123.1 KII63932.1 - 0.093 11.9 0.0 0.24 10.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4290) DUF2827 PF10933.3 KII63932.1 - 0.13 10.7 0.1 0.17 10.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2827) ING PF12998.2 KII63932.1 - 0.15 12.3 0.8 0.36 11.1 0.3 1.8 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF1759 PF03564.10 KII63933.1 - 7.5e-08 32.2 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) SWIB PF02201.13 KII63933.1 - 0.03 13.9 0.0 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 SWIB/MDM2 domain Sigma_reg_N PF13800.1 KII63935.1 - 0.098 12.6 0.1 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF3974 PF13120.1 KII63935.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3974) Mtp PF03821.11 KII63935.1 - 0.16 11.3 1.3 0.19 11.1 0.9 1.1 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter Pox_A14 PF05767.7 KII63935.1 - 0.25 11.3 2.8 0.62 10.0 2.1 1.5 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 DEAD PF00270.24 KII63936.1 - 3.3e-43 147.1 0.0 2.4e-42 144.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII63936.1 - 2.4e-26 91.3 0.2 1.1e-25 89.2 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.24 KII63936.1 - 8.4e-12 44.5 0.5 2.1e-11 43.2 0.3 1.7 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KII63936.1 - 1.7e-09 37.1 0.5 3.8e-09 35.9 0.4 1.7 1 0 0 1 1 1 1 KH domain SNF2_N PF00176.18 KII63936.1 - 5e-06 25.5 0.0 9.4e-06 24.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain CMS1 PF14617.1 KII63936.1 - 0.0005 19.2 0.5 0.0057 15.7 0.0 2.3 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.10 KII63936.1 - 0.0016 18.2 0.0 0.0053 16.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit KH_2 PF07650.12 KII63936.1 - 0.0035 16.8 0.0 0.013 15.0 0.0 1.9 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 KII63936.1 - 0.0081 15.7 0.1 0.021 14.4 0.1 1.7 1 0 0 1 1 1 1 KH domain KH_5 PF13184.1 KII63936.1 - 0.084 12.6 0.0 0.3 10.9 0.0 1.9 1 0 0 1 1 1 0 NusA-like KH domain RVT_1 PF00078.22 KII63940.1 - 2.2e-15 56.5 0.1 5e-15 55.4 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) HEAT PF02985.17 KII63941.1 - 8.5e-06 25.4 0.6 0.58 10.3 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 KII63941.1 - 0.0011 19.4 0.0 2.3 8.8 0.0 4.1 4 0 0 4 4 4 1 HEAT-like repeat A2M_comp PF07678.9 KII63941.1 - 0.075 12.2 0.2 0.13 11.4 0.2 1.3 1 0 0 1 1 1 0 A-macroglobulin complement component HEAT_2 PF13646.1 KII63941.1 - 0.17 12.2 0.0 2.3 8.5 0.0 2.4 2 0 0 2 2 2 0 HEAT repeats FKBP_C PF00254.23 KII63942.1 - 2.8e-15 56.1 0.0 8.7e-15 54.5 0.0 1.9 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 KII63942.1 - 2e-09 36.9 2.2 3.2e-05 23.4 1.1 2.5 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KII63942.1 - 4.2e-07 29.2 2.2 0.19 11.3 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII63942.1 - 5.2e-07 29.0 1.2 0.097 12.6 1.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII63942.1 - 4.6e-05 23.2 0.1 0.032 14.1 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KII63942.1 - 0.00014 22.1 0.3 0.0074 16.5 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 KII63942.1 - 0.0043 17.1 2.4 0.0043 17.1 1.7 2.7 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 KII63942.1 - 0.0087 16.7 0.0 5.8 7.7 0.8 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII63942.1 - 0.012 15.4 0.4 0.066 13.0 0.0 2.4 2 1 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.1 KII63942.1 - 0.27 11.1 0.0 0.27 11.1 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3194 PF11419.3 KII63944.1 - 0.012 15.7 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) ADSL_C PF10397.4 KII63944.1 - 0.12 12.3 0.1 0.25 11.3 0.1 1.5 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus Kunitz_BPTI PF00014.18 KII63946.1 - 0.0025 17.9 5.7 0.0035 17.5 3.9 1.2 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Defensin_big PF14862.1 KII63946.1 - 1.1 9.4 6.4 0.84 9.7 1.6 2.1 2 0 0 2 2 2 0 Big defensin AzlC PF03591.9 KII63950.1 - 0.077 12.9 0.1 0.099 12.5 0.1 1.4 1 0 0 1 1 1 0 AzlC protein Glycos_transf_2 PF00535.21 KII63952.1 - 3.8e-13 49.4 0.1 6.9e-13 48.6 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 ADK PF00406.17 KII63953.1 - 7.2e-13 48.6 0.0 8.3e-13 48.4 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase TMEM154 PF15102.1 KII63954.1 - 0.00027 20.6 13.4 0.00057 19.6 9.3 1.6 1 1 0 1 1 1 1 TMEM154 protein family EVI2A PF05399.6 KII63954.1 - 0.00038 19.7 4.3 0.00043 19.5 3.0 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) CD34_antigen PF06365.7 KII63954.1 - 0.00086 19.0 4.9 0.0015 18.2 3.4 1.3 1 1 0 1 1 1 1 CD34/Podocalyxin family Rifin_STEVOR PF02009.11 KII63954.1 - 0.0015 18.2 0.7 0.0017 18.0 0.5 1.0 1 0 0 1 1 1 1 Rifin/stevor family Podoplanin PF05808.6 KII63954.1 - 0.0019 17.7 7.0 0.0025 17.3 4.9 1.1 1 0 0 1 1 1 1 Podoplanin AJAP1_PANP_C PF15298.1 KII63954.1 - 0.012 15.5 5.6 0.014 15.3 3.9 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Tetraspannin PF00335.15 KII63954.1 - 0.029 13.6 1.4 0.034 13.4 0.7 1.3 1 1 0 1 1 1 0 Tetraspanin family Plasmodium_Vir PF05795.6 KII63954.1 - 0.041 13.0 2.9 0.045 12.9 2.0 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TrbL PF04610.9 KII63954.1 - 0.041 13.5 0.0 0.049 13.3 0.0 1.1 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein DUF4448 PF14610.1 KII63954.1 - 0.047 13.1 0.1 0.07 12.6 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Ycf1 PF05758.7 KII63954.1 - 0.056 11.1 1.5 0.053 11.2 1.0 1.1 1 0 0 1 1 1 0 Ycf1 Tim54 PF11711.3 KII63954.1 - 0.06 11.9 2.0 0.066 11.7 1.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pox_P21 PF05313.7 KII63954.1 - 0.079 12.2 0.8 0.14 11.4 0.5 1.3 1 0 0 1 1 1 0 Poxvirus P21 membrane protein TRP PF06011.7 KII63954.1 - 0.11 10.9 0.3 0.13 10.7 0.2 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel ETRAMP PF09716.5 KII63954.1 - 0.21 11.5 1.3 0.43 10.5 0.9 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3753 PF12575.3 KII63954.1 - 0.28 11.0 2.7 0.25 11.1 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3753) Nucleoside_tran PF01733.13 KII63954.1 - 0.5 9.4 2.9 0.59 9.2 2.0 1.2 1 0 0 1 1 1 0 Nucleoside transporter DUF3357 PF11837.3 KII63954.1 - 0.73 9.7 3.5 0.55 10.1 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF912 PF06024.7 KII63954.1 - 1.9 8.5 7.5 10 6.2 5.2 1.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1632 PF07857.7 KII63954.1 - 3.6 6.7 6.9 0.65 9.2 1.1 2.0 1 1 1 2 2 2 0 CEO family (DUF1632) Pkinase PF00069.20 KII63958.1 - 3.1e-37 128.1 0.5 4.8e-37 127.5 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII63958.1 - 8.7e-14 51.2 0.1 1.1e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SNARE PF05739.14 KII63959.1 - 5.5e-08 32.3 1.1 9.6e-08 31.5 0.7 1.4 1 0 0 1 1 1 1 SNARE domain Synaptobrevin PF00957.16 KII63959.1 - 0.0061 16.1 0.3 0.013 15.0 0.2 1.5 1 0 0 1 1 1 1 Synaptobrevin Sec8_exocyst PF04048.9 KII63959.1 - 0.076 12.6 1.2 0.14 11.7 0.1 2.1 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain IMPDH PF00478.20 KII63960.1 - 1.1e-12 47.6 0.0 1.1e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain IMPDH PF00478.20 KII63961.1 - 2.2e-67 227.4 4.7 2.8e-67 227.1 3.3 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 KII63961.1 - 0.00012 21.0 0.6 0.0002 20.3 0.4 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Asp_protease_2 PF13650.1 KII63964.1 - 0.00051 20.4 0.1 0.00073 19.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Lgl_C PF08596.5 KII63964.1 - 0.031 12.7 0.1 0.034 12.6 0.1 1.1 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal MULE PF10551.4 KII63966.1 - 6.4e-06 26.2 0.1 1.3e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 MULE transposase domain DUF4312 PF14189.1 KII63968.1 - 0.032 14.0 0.1 0.089 12.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4312) zf-UBR PF02207.15 KII63970.1 - 5.5e-13 48.4 20.6 1e-12 47.5 14.3 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DUF482 PF04339.7 KII63971.1 - 0.022 13.6 0.1 0.033 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF482 B2 PF11473.3 KII63972.1 - 0.023 14.2 0.1 0.39 10.3 0.0 2.1 1 1 1 2 2 2 0 RNA binding protein B2 BEN PF10523.4 KII63972.1 - 0.1 12.6 0.1 14 5.8 0.0 2.2 1 1 1 2 2 2 0 BEN domain Glycos_transf_2 PF00535.21 KII63974.1 - 1.2e-26 93.4 0.0 2.1e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.17 KII63974.1 - 5.3e-11 42.6 9.5 1e-10 41.6 6.6 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.9 KII63974.1 - 2.2e-07 30.2 0.8 6.2e-07 28.8 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.4 KII63974.1 - 2.6e-05 23.4 0.0 0.00034 19.8 0.0 2.4 2 1 0 2 2 2 1 Glycosyltransferase like family 2 CDtoxinA PF03498.9 KII63974.1 - 0.0057 16.0 6.4 0.01 15.2 1.5 2.3 1 1 1 2 2 2 1 Cytolethal distending toxin A/C family LANC_like PF05147.8 KII63975.1 - 0.016 13.7 0.1 0.018 13.6 0.1 1.1 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein DUF2052 PF09747.4 KII63976.1 - 3e-16 59.8 12.6 5.9e-14 52.3 8.7 2.4 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Xpo1 PF08389.7 KII63977.1 - 0.0035 17.2 0.5 0.019 14.9 0.0 2.1 2 1 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.14 KII63977.1 - 0.0046 16.8 1.1 0.16 11.8 0.2 2.4 1 1 1 2 2 2 1 Importin-beta N-terminal domain MAGE PF01454.14 KII63977.1 - 0.08 12.2 0.1 0.093 12.0 0.1 1.2 1 0 0 1 1 1 0 MAGE family Nop14 PF04147.7 KII63978.1 - 5.9 4.6 6.6 7.7 4.2 1.9 2.2 1 1 1 2 2 2 0 Nop14-like family DDE_3 PF13358.1 KII63979.1 - 1.4e-06 28.1 0.1 4.3e-06 26.5 0.1 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease Adipogenin PF15202.1 KII63982.1 - 0.0029 17.4 0.1 0.0046 16.7 0.1 1.3 1 0 0 1 1 1 1 Adipogenin rve PF00665.21 KII63983.1 - 5.9e-14 52.2 0.0 9e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII63983.1 - 1e-05 24.9 0.1 2.8e-05 23.5 0.1 1.7 1 1 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII63983.1 - 0.069 12.9 0.0 0.095 12.4 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease Ribonuc_L-PSP PF01042.16 KII63984.1 - 2.3e-33 114.5 0.0 2.5e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Ssu72 PF04722.8 KII63988.1 - 5.9e-11 42.0 0.1 4.1e-10 39.2 0.1 2.0 1 1 0 1 1 1 1 Ssu72-like protein Trp_Tyr_perm PF03222.8 KII63991.1 - 2.1e-05 23.5 9.3 3.1e-05 22.9 6.3 1.4 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family RNA_pol_Rpb4 PF03874.11 KII63993.1 - 1.1e-18 67.3 3.0 1.3e-18 67.0 2.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 PNPase PF03726.9 KII63993.1 - 0.73 10.1 3.5 11 6.3 1.8 2.7 1 1 1 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain H_lectin PF09458.5 KII63994.1 - 0.0064 16.1 0.2 0.019 14.6 0.2 1.7 1 0 0 1 1 1 1 H-type lectin domain MULE PF10551.4 KII63994.1 - 0.058 13.5 0.4 9.2 6.5 0.0 2.9 2 1 1 3 3 3 0 MULE transposase domain Pox_F11 PF04943.7 KII63995.1 - 0.014 14.3 0.2 0.016 14.1 0.1 1.1 1 0 0 1 1 1 0 Poxvirus F11 protein Rotamase PF00639.16 KII63996.1 - 5.3e-20 71.9 0.1 2e-19 70.1 0.1 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KII63996.1 - 1.1e-19 70.8 0.1 2.5e-19 69.6 0.1 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KII63996.1 - 9.7e-07 29.4 0.0 1.7e-06 28.6 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Alpha_adaptin_C PF02296.11 KII63997.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Alpha adaptin AP2, C-terminal domain Thymidylate_kin PF02223.12 KII63998.1 - 0.02 14.2 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase Transposase_mut PF00872.13 KII63998.1 - 0.046 12.2 1.2 0.055 12.0 0.8 1.3 1 0 0 1 1 1 0 Transposase, Mutator family DUF4096 PF13340.1 KII63999.1 - 0.037 13.8 0.1 3.3 7.6 0.0 2.2 2 0 0 2 2 2 0 Putative transposase of IS4/5 family (DUF4096) DDE_1 PF03184.14 KII64002.1 - 3.9e-16 58.8 0.1 7.4e-16 57.9 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII64002.1 - 7.1e-12 44.9 0.1 1.9e-11 43.6 0.1 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain eIF-1a PF01176.14 KII64004.1 - 1.7e-22 78.6 0.0 2.5e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 COX5A PF02284.11 KII64005.1 - 1.3e-10 41.1 0.0 1.5e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DDE_Tnp_IS1595 PF12762.2 KII64006.1 - 4.1e-14 52.6 0.0 6.3e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII64006.1 - 0.00026 20.2 0.0 0.00038 19.7 0.0 1.1 1 0 0 1 1 1 1 Transposase IS66 family Ta0938 PF11494.3 KII64006.1 - 0.022 14.8 0.1 0.047 13.7 0.1 1.5 1 0 0 1 1 1 0 Ta0938 DDE_Tnp_IS1595 PF12762.2 KII64007.1 - 2e-06 27.7 0.0 5.8e-06 26.2 0.0 1.7 1 1 0 2 2 2 1 ISXO2-like transposase domain DUF2392 PF10288.4 KII64011.1 - 0.029 14.7 0.1 0.36 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2392) DUF2630 PF10944.3 KII64011.1 - 0.048 13.7 0.1 3.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) Nucleoside_tran PF01733.13 KII64013.1 - 6.3e-20 71.5 4.9 6.9e-20 71.4 3.4 1.0 1 0 0 1 1 1 1 Nucleoside transporter Sugar_tr PF00083.19 KII64013.1 - 0.035 12.6 0.2 0.035 12.6 0.1 1.3 2 0 0 2 2 2 0 Sugar (and other) transporter DUF4149 PF13664.1 KII64013.1 - 0.12 12.4 3.2 0.34 10.9 2.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) Ldl_recept_a PF00057.13 KII64014.1 - 8.5e-50 166.3 129.9 3.9e-11 42.6 7.5 8.1 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII64014.1 - 0.26 11.2 5.3 22 5.4 0.4 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat Glyco_hydro_15 PF00723.16 KII64016.1 - 4.1e-19 68.4 0.0 4.9e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 TIP120 PF08623.5 KII64016.1 - 0.0038 16.8 0.2 0.0074 15.8 0.1 1.4 1 0 0 1 1 1 1 TATA-binding protein interacting (TIP20) Glyco_hydro_15 PF00723.16 KII64017.1 - 9e-81 271.7 0.0 1.1e-80 271.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 SGT1 PF07093.6 KII64019.1 - 1.1e-26 93.4 11.4 4.3e-24 84.8 1.4 3.0 1 1 1 2 2 2 2 SGT1 protein KTI12 PF08433.5 KII64019.1 - 0.0071 15.5 0.1 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 VP9 PF09625.5 KII64020.1 - 0.17 11.7 0.6 0.29 10.9 0.1 1.6 2 0 0 2 2 2 0 VP9 protein BNR PF02012.15 KII64021.1 - 0.00016 21.0 2.1 0.35 10.8 0.1 3.3 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF2806 PF10987.3 KII64021.1 - 0.0016 17.9 0.1 0.0018 17.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2806) Mo-co_dimer PF03404.11 KII64021.1 - 0.12 11.9 0.0 2 8.0 0.0 2.2 2 0 0 2 2 2 0 Mo-co oxidoreductase dimerisation domain DUF3829 PF12889.2 KII64023.1 - 0.0021 17.3 1.2 0.0025 17.0 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3829) GCV_H PF01597.14 KII64023.1 - 0.011 15.4 0.2 0.014 15.0 0.1 1.2 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF2340 PF10209.4 KII64023.1 - 0.021 14.9 0.3 0.026 14.6 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) DUF3209 PF11483.3 KII64023.1 - 0.035 14.4 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) Snapin_Pallidin PF14712.1 KII64023.1 - 0.045 14.0 0.2 0.079 13.2 0.1 1.4 1 0 0 1 1 1 0 Snapin/Pallidin DUF1204 PF06721.6 KII64023.1 - 0.047 12.9 0.1 0.093 11.9 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1204) DUF3276 PF11680.3 KII64023.1 - 0.086 12.6 3.1 0.14 11.9 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3276) DSPc PF00782.15 KII64023.1 - 0.091 12.3 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Apo-CIII PF05778.7 KII64023.1 - 0.1 11.9 0.0 0.23 10.8 0.0 1.6 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) SNAP PF14938.1 KII64024.1 - 2.2e-06 27.0 4.2 3.3e-06 26.4 2.9 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Amidase02_C PF12123.3 KII64024.1 - 0.0011 18.5 0.0 0.0024 17.4 0.0 1.5 1 0 0 1 1 1 1 N-acetylmuramoyl-l-alanine amidase NikR_C PF08753.6 KII64025.1 - 0.073 12.9 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 NikR C terminal nickel binding domain rve PF00665.21 KII64026.1 - 0.0008 19.5 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII64026.1 - 0.0013 18.2 0.0 0.0027 17.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain FANCI_S2 PF14676.1 KII64027.1 - 0.07 13.0 0.6 1.4 8.7 0.0 3.0 3 0 0 3 3 3 0 FANCI solenoid 2 Rota_NS6 PF04866.7 KII64027.1 - 0.21 11.6 2.1 0.37 10.8 0.1 2.4 3 0 0 3 3 3 0 Rotavirus non-structural protein 6 DUF4488 PF14869.1 KII64029.1 - 0.053 13.0 2.0 0.098 12.2 0.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4488) DUF2232 PF09991.4 KII64030.1 - 0.009 15.0 0.1 0.011 14.7 0.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) TMEM154 PF15102.1 KII64030.1 - 0.018 14.7 0.4 0.02 14.5 0.3 1.2 1 0 0 1 1 1 0 TMEM154 protein family S1FA PF04689.8 KII64030.1 - 0.021 14.6 0.6 1.3 8.9 0.1 2.2 2 0 0 2 2 2 0 DNA binding protein S1FA CD34_antigen PF06365.7 KII64030.1 - 0.067 12.8 0.4 0.09 12.4 0.3 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Tmemb_9 PF05434.6 KII64030.1 - 0.28 10.9 6.0 0.41 10.3 4.2 1.4 1 1 0 1 1 1 0 TMEM9 ETRAMP PF09716.5 KII64030.1 - 0.41 10.6 3.5 0.74 9.8 2.4 1.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Herpes_US9 PF06072.6 KII64030.1 - 2.4 8.0 4.6 1.1 9.1 0.5 2.0 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 DUF2116 PF09889.4 KII64030.1 - 8.6 6.2 6.3 1.3 8.8 0.2 2.3 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF1682 PF07946.9 KII64031.1 - 0.0012 17.8 1.0 0.0015 17.4 0.7 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1682) Trehalose_PPase PF02358.11 KII64031.1 - 0.033 13.0 0.0 0.038 12.8 0.0 1.1 1 0 0 1 1 1 0 Trehalose-phosphatase MTBP_N PF14918.1 KII64031.1 - 0.066 12.6 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 MDM2-binding UXS1_N PF11803.3 KII64031.1 - 0.074 12.8 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal BNR PF02012.15 KII64032.1 - 0.0019 17.7 0.1 3.1 8.0 0.0 2.6 2 0 0 2 2 2 2 BNR/Asp-box repeat DDE_Tnp_IS1595 PF12762.2 KII64033.1 - 0.0019 18.0 1.4 0.0024 17.7 0.9 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Ldl_recept_a PF00057.13 KII64036.1 - 2.5e-09 36.8 25.0 2.2e-07 30.6 5.4 2.4 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII64036.1 - 1.1 8.8 16.1 1.6 8.3 11.2 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like SNAP PF14938.1 KII64037.1 - 0.00061 19.0 0.3 0.00068 18.8 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF3907 PF13047.1 KII64037.1 - 0.0066 16.0 1.3 0.008 15.8 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3907) HSL_N PF06350.7 KII64037.1 - 0.02 14.0 0.5 0.02 13.9 0.3 1.1 1 0 0 1 1 1 0 Hormone-sensitive lipase (HSL) N-terminus APG17 PF04108.7 KII64037.1 - 0.046 12.5 0.4 0.054 12.2 0.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 SHP PF03579.8 KII64038.1 - 0.079 12.3 3.2 0.11 11.8 2.2 1.3 1 0 0 1 1 1 0 Small hydrophobic protein E1_DerP2_DerF2 PF02221.10 KII64039.1 - 0.0014 18.8 0.1 0.0018 18.4 0.1 1.2 1 0 0 1 1 1 1 ML domain AT_hook PF02178.14 KII64040.1 - 0.022 14.3 1.4 0.059 13.0 1.0 1.7 1 0 0 1 1 1 0 AT hook motif Got1 PF04178.7 KII64041.1 - 6.8e-21 74.5 18.1 8.9e-21 74.1 12.6 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family PGG PF13962.1 KII64041.1 - 0.011 15.3 11.2 0.51 9.9 0.4 2.5 1 1 1 2 2 2 0 Domain of unknown function DUF3566 PF12089.3 KII64041.1 - 0.019 14.9 5.2 0.027 14.4 3.6 1.3 1 0 0 1 1 1 0 Transmembrane domain of unknown function (DUF3566) DUF4605 PF15378.1 KII64041.1 - 0.093 12.4 3.1 0.3 10.8 2.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) DUF2516 PF10724.4 KII64041.1 - 6.5 6.8 8.6 2.9 7.9 4.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2516) DDE_3 PF13358.1 KII64042.1 - 0.00043 20.0 0.0 0.00064 19.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease CHB_HEX_C_1 PF13290.1 KII64045.1 - 0.0018 18.0 1.3 0.0052 16.5 0.9 1.8 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain BNR PF02012.15 KII64045.1 - 0.014 15.0 8.6 0.88 9.6 0.1 3.7 3 0 0 3 3 3 0 BNR/Asp-box repeat DUF1635 PF07795.6 KII64046.1 - 0.097 12.0 2.5 0.11 11.8 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Serpin PF00079.15 KII64047.1 - 1.1e-15 57.6 0.3 1.3e-15 57.4 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.1 KII64048.1 - 0.01 15.0 0.1 0.01 14.9 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Asp_protease_2 PF13650.1 KII64051.1 - 9.1e-05 22.8 0.0 0.00019 21.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII64051.1 - 0.00034 20.4 0.0 0.026 14.4 0.0 2.4 1 1 1 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII64051.1 - 0.083 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease PCYCGC PF13798.1 KII64051.1 - 1.1 8.8 6.1 6.2 6.4 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function with PCYCGC motif Serpin PF00079.15 KII64052.1 - 2.5e-37 128.8 0.9 2.9e-37 128.6 0.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII64053.1 - 6.4e-25 88.0 0.6 7.6e-25 87.8 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Dymeclin PF09742.4 KII64055.1 - 0.1 10.6 0.1 0.11 10.5 0.1 1.0 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein Serpin PF00079.15 KII64056.1 - 2.3e-24 86.2 0.3 2.7e-24 86.0 0.2 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII64057.1 - 1.1e-18 67.5 2.0 1.3e-18 67.2 1.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RuBisCO_small PF00101.15 KII64057.1 - 0.08 12.7 0.1 0.21 11.4 0.1 1.7 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase, small chain Serpin PF00079.15 KII64058.1 - 4.5e-48 164.2 2.2 5.1e-48 164.0 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Arylsulfotran_2 PF14269.1 KII64058.1 - 0.014 14.5 0.2 0.07 12.2 0.0 1.9 2 0 0 2 2 2 0 Arylsulfotransferase (ASST) ABC2_membrane_4 PF12730.2 KII64060.1 - 0.016 14.3 1.4 0.016 14.3 1.0 1.4 2 0 0 2 2 2 0 ABC-2 family transporter protein Rifin_STEVOR PF02009.11 KII64060.1 - 0.024 14.2 0.2 0.049 13.2 0.0 1.5 1 1 0 1 1 1 0 Rifin/stevor family DUF912 PF06024.7 KII64060.1 - 0.048 13.7 0.1 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MSP PF01716.13 KII64061.1 - 0.096 11.7 0.0 0.22 10.5 0.0 1.4 1 1 0 1 1 1 0 Manganese-stabilising protein / photosystem II polypeptide Poxvirus_B22R PF04395.7 KII64062.1 - 0.014 14.8 1.2 0.017 14.6 0.9 1.2 1 0 0 1 1 1 0 Poxvirus B22R protein PCMT PF01135.14 KII64063.1 - 8.9e-20 71.1 0.0 1.1e-19 70.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KII64063.1 - 0.00011 21.7 0.0 0.00013 21.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 KII64063.1 - 0.00099 18.2 0.0 0.0012 17.8 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 KII64063.1 - 0.0079 16.7 0.0 0.01 16.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KII64063.1 - 0.0086 15.8 0.0 0.009 15.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KII64063.1 - 0.01 15.4 0.0 0.013 15.1 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain RVT_1 PF00078.22 KII64066.1 - 1.9e-25 89.5 0.2 7e-25 87.6 0.3 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII64066.1 - 1.8e-22 79.7 0.0 3.9e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII64066.1 - 3.9e-08 33.1 0.0 6.4e-07 29.2 0.0 2.4 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII64066.1 - 4.3e-05 23.2 3.2 0.00011 21.9 2.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII64066.1 - 0.00018 21.9 0.1 0.0011 19.4 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease rve_3 PF13683.1 KII64066.1 - 0.0037 16.7 0.1 0.051 13.0 0.0 2.9 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.9 KII64066.1 - 0.017 15.0 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII64066.1 - 0.03 14.1 0.0 0.074 12.8 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII64066.1 - 0.11 12.0 0.1 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Mad3_BUB1_II PF08171.6 KII64068.1 - 0.19 11.6 1.0 0.33 10.8 0.7 1.4 1 0 0 1 1 1 0 Mad3/BUB1 homology region 2 DUF2652 PF10851.3 KII64069.1 - 0.072 13.0 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2652) RasGAP_C PF03836.10 KII64072.1 - 0.055 13.1 0.5 0.069 12.8 0.4 1.2 1 0 0 1 1 1 0 RasGAP C-terminus RVT_1 PF00078.22 KII64073.1 - 0.0098 15.2 0.1 0.019 14.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAM92 PF06730.6 KII64073.1 - 0.07 12.4 0.5 0.088 12.1 0.3 1.1 1 0 0 1 1 1 0 FAM92 protein Xpo1 PF08389.7 KII64074.1 - 0.0034 17.3 1.6 0.38 10.6 0.2 2.0 1 1 1 2 2 2 2 Exportin 1-like protein DNA_pol_A_exo1 PF01612.15 KII64075.1 - 0.061 12.7 0.1 0.12 11.8 0.1 1.4 1 1 0 1 1 1 0 3'-5' exonuclease Rop-like PF05082.8 KII64075.1 - 0.16 11.4 0.3 0.49 9.8 0.1 2.0 2 1 0 2 2 2 0 Rop-like Poty_coat PF00767.13 KII64077.1 - 0.055 12.7 0.0 0.082 12.1 0.0 1.2 1 0 0 1 1 1 0 Potyvirus coat protein CsgG PF03783.9 KII64078.1 - 0.17 10.9 0.9 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 Curli production assembly/transport component CsgG DUF3800 PF12686.2 KII64083.1 - 4.6e-13 49.3 0.0 2.2e-06 27.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3800) Acyl-ACP_TE PF01643.12 KII64083.1 - 0.1 11.4 0.1 0.17 10.8 0.1 1.2 1 0 0 1 1 1 0 Acyl-ACP thioesterase Phage_int_SAM_4 PF13495.1 KII64085.1 - 0.019 15.3 0.0 0.031 14.5 0.0 1.3 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain GFP PF01353.17 KII64086.1 - 0.14 11.4 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 Green fluorescent protein HTH_Tnp_Tc5 PF03221.11 KII64087.1 - 4.2e-10 39.3 0.1 8e-10 38.3 0.0 1.5 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain MULE PF10551.4 KII64089.1 - 0.00016 21.7 0.2 0.0015 18.6 0.2 2.0 2 0 0 2 2 2 1 MULE transposase domain Pox_L3_FP4 PF03339.9 KII64090.1 - 0.029 12.8 0.6 0.034 12.6 0.4 1.2 1 0 0 1 1 1 0 Poxvirus L3/FP4 protein V-ATPase_C PF03223.10 KII64093.1 - 2.2e-93 313.1 10.4 2.4e-93 313.0 7.2 1.0 1 0 0 1 1 1 1 V-ATPase subunit C MetW PF07021.7 KII64093.1 - 0.018 14.4 0.3 0.03 13.6 0.2 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Sipho_Gp157 PF05565.6 KII64093.1 - 0.04 13.4 0.3 0.04 13.4 0.2 2.3 3 0 0 3 3 3 0 Siphovirus Gp157 Imm26 PF15572.1 KII64093.1 - 0.059 13.4 0.7 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 Immunity protein 26 FAM176 PF14851.1 KII64094.1 - 0.046 13.3 0.2 0.066 12.8 0.2 1.2 1 0 0 1 1 1 0 FAM176 family Pex24p PF06398.6 KII64094.1 - 0.13 11.0 1.4 0.32 9.7 1.0 1.8 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin OAD_gamma PF04277.8 KII64094.1 - 6.2 7.2 6.8 22 5.5 4.7 1.8 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain MCLC PF05934.6 KII64100.1 - 8.4e-06 24.3 1.7 1.1e-05 24.0 1.2 1.1 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) GNT-I PF03071.10 KII64101.1 - 3.9e-77 259.6 0.9 4.6e-77 259.3 0.6 1.0 1 0 0 1 1 1 1 GNT-I family RVT_1 PF00078.22 KII64102.1 - 1.3e-06 27.9 0.0 1.5e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Bac_export_3 PF01313.14 KII64105.1 - 0.027 14.1 0.2 0.057 13.0 0.1 1.5 1 0 0 1 1 1 0 Bacterial export proteins, family 3 Leukemia_assc_2 PF15197.1 KII64105.1 - 3.1 7.5 5.1 18 5.1 0.1 2.3 2 0 0 2 2 2 0 Leukemia-associated protein 2 GNT-I PF03071.10 KII64106.1 - 5.5e-12 44.9 0.1 7e-12 44.6 0.1 1.1 1 0 0 1 1 1 1 GNT-I family FtsH_ext PF06480.10 KII64106.1 - 0.026 14.6 0.1 0.033 14.3 0.1 1.3 1 0 0 1 1 1 0 FtsH Extracellular GNT-I PF03071.10 KII64107.1 - 1.9e-34 118.9 0.2 2.1e-34 118.8 0.1 1.0 1 0 0 1 1 1 1 GNT-I family Phage_Gp23 PF10669.4 KII64109.1 - 0.11 12.5 3.5 0.06 13.4 0.5 1.9 1 1 0 2 2 2 0 Protein gp23 (Bacteriophage A118) XisI PF08869.6 KII64110.1 - 0.027 14.5 0.3 0.042 13.9 0.2 1.4 1 0 0 1 1 1 0 XisI protein Chordopox_A33R PF05966.7 KII64110.1 - 0.038 12.7 0.1 0.078 11.7 0.0 1.4 1 1 0 1 1 1 0 Chordopoxvirus A33R protein rve PF00665.21 KII64110.1 - 0.044 13.8 0.1 0.12 12.5 0.1 1.7 2 0 0 2 2 2 0 Integrase core domain DDE_Tnp_Tn3 PF01526.12 KII64111.1 - 0.054 12.0 0.2 0.057 12.0 0.2 1.0 1 0 0 1 1 1 0 Tn3 transposase DDE domain Suppressor_APC PF11414.3 KII64113.1 - 0.051 13.3 1.7 0.064 13.0 0.6 1.8 1 1 1 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein Toprim_Crpt PF13342.1 KII64113.1 - 0.066 12.8 0.9 0.12 12.0 0.6 1.5 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase DUF3160 PF11369.3 KII64113.1 - 0.12 10.7 2.3 0.11 10.7 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3160) RE_Alw26IDE PF09665.5 KII64113.1 - 0.48 9.0 4.3 0.54 8.8 3.0 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) Muted PF14942.1 KII64113.1 - 0.61 9.9 6.0 0.69 9.7 4.2 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein PRD PF00874.15 KII64113.1 - 0.95 9.6 8.1 1.9 8.6 3.9 2.0 1 1 1 2 2 2 0 PRD domain Nup54 PF13874.1 KII64113.1 - 1.8 8.2 6.9 2.4 7.8 4.8 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Fib_alpha PF08702.5 KII64113.1 - 3.7 7.6 8.8 4.6 7.3 6.1 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family RVP PF00077.15 KII64114.1 - 1.2e-05 25.1 0.0 2.6e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII64114.1 - 4.4e-05 23.9 0.0 0.00014 22.2 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KII64114.1 - 5.7e-05 22.8 0.0 0.00012 21.7 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII64114.1 - 0.00014 21.5 0.9 0.00014 21.5 0.6 2.9 2 1 0 2 2 2 1 Zinc knuckle Asp_protease PF09668.5 KII64114.1 - 0.015 14.8 0.0 0.051 13.1 0.0 1.9 1 1 0 1 1 1 0 Aspartyl protease Osmo_CC PF08946.5 KII64115.1 - 0.02 14.8 1.9 0.044 13.7 1.3 1.6 1 0 0 1 1 1 0 Osmosensory transporter coiled coil LXG PF04740.7 KII64115.1 - 0.03 14.1 5.4 0.041 13.6 3.8 1.2 1 0 0 1 1 1 0 LXG domain of WXG superfamily ATG16 PF08614.6 KII64115.1 - 0.037 13.8 5.3 0.041 13.7 0.4 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4201 PF13870.1 KII64115.1 - 0.06 12.7 9.2 0.085 12.2 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) TcdA_TcdB PF12919.2 KII64115.1 - 0.6 8.5 7.2 0.72 8.2 5.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Phage_GP20 PF06810.6 KII64115.1 - 1.5 8.2 10.9 2.1 7.8 6.0 2.0 1 1 0 1 1 1 0 Phage minor structural protein GP20 DUF2098 PF09871.4 KII64115.1 - 1.5 8.8 6.5 0.83 9.6 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) IncA PF04156.9 KII64115.1 - 3 7.3 9.3 15 5.0 6.5 1.8 1 1 0 1 1 1 0 IncA protein CAP18_C PF12153.3 KII64117.1 - 0.00034 20.1 0.3 0.001 18.6 0.1 1.9 1 1 1 2 2 2 1 LPS binding domain of CAP18 (C terminal) ATG16 PF08614.6 KII64117.1 - 0.0019 18.0 1.8 0.0019 18.0 1.3 2.3 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) Baculo_PEP_C PF04513.7 KII64117.1 - 0.013 15.3 0.2 0.017 14.9 0.1 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 KII64117.1 - 0.018 14.6 13.8 0.057 13.0 3.3 2.1 1 1 1 2 2 2 0 IncA protein Noelin-1 PF12308.3 KII64117.1 - 0.021 14.5 0.4 0.043 13.6 0.3 1.5 1 0 0 1 1 1 0 Neurogenesis glycoprotein DUF3573 PF12097.3 KII64117.1 - 0.024 13.2 4.1 0.039 12.5 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) ELYS PF13934.1 KII64117.1 - 0.029 14.0 0.2 0.039 13.6 0.2 1.2 1 0 0 1 1 1 0 Nuclear pore complex assembly Suppressor_APC PF11414.3 KII64117.1 - 0.037 13.8 6.1 0.32 10.8 0.5 2.9 2 1 1 3 3 2 0 Adenomatous polyposis coli tumour suppressor protein LUC7 PF03194.10 KII64117.1 - 0.044 13.3 5.9 0.061 12.8 3.9 1.4 1 1 0 1 1 1 0 LUC7 N_terminus MbeD_MobD PF04899.7 KII64117.1 - 0.066 13.1 0.1 0.18 11.7 0.1 1.8 1 0 0 1 1 1 0 MbeD/MobD like DUF1664 PF07889.7 KII64117.1 - 0.11 12.3 0.5 0.19 11.5 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Lebercilin PF15619.1 KII64117.1 - 0.15 11.4 9.9 0.21 10.9 6.9 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease APG6 PF04111.7 KII64117.1 - 0.17 10.8 9.3 0.23 10.4 6.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.7 KII64117.1 - 0.28 10.9 8.5 0.17 11.5 0.8 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.14 KII64117.1 - 0.55 8.0 6.0 0.65 7.7 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF416 PF04222.7 KII64117.1 - 0.66 9.0 5.3 0.44 9.6 1.4 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF416) DivIC PF04977.10 KII64117.1 - 0.86 9.1 5.2 0.19 11.2 0.5 2.2 2 1 0 2 2 2 0 Septum formation initiator Syntaxin-6_N PF09177.6 KII64117.1 - 1.2 9.5 8.4 0.26 11.6 1.8 2.5 1 1 2 3 3 3 0 Syntaxin 6, N-terminal FlgN PF05130.7 KII64117.1 - 1.6 8.9 6.0 6.6 6.9 3.7 1.9 1 1 0 1 1 1 0 FlgN protein MRP-L46 PF11788.3 KII64117.1 - 2.7 8.6 11.6 4.2 8.0 0.1 3.1 2 1 1 3 3 3 0 39S mitochondrial ribosomal protein L46 HR1 PF02185.11 KII64117.1 - 3.1 7.6 7.2 0.5 10.1 1.1 2.5 1 1 2 3 3 3 0 Hr1 repeat CENP-F_leu_zip PF10473.4 KII64117.1 - 3.1 7.6 11.9 95 2.8 8.3 2.2 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.17 KII64117.1 - 3.6 7.6 9.0 1.1 9.3 2.0 2.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.6 KII64117.1 - 4.7 7.1 5.6 21 5.0 3.9 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) SPX PF03105.14 KII64117.1 - 7.5 6.2 10.3 12 5.5 7.1 1.4 1 1 0 1 1 1 0 SPX domain DUF3148 PF11347.3 KII64118.1 - 0.0011 18.4 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3148) Mrr_N PF14338.1 KII64119.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Mrr N-terminal domain Gin PF10764.4 KII64122.1 - 0.0061 16.2 1.2 0.18 11.5 0.0 2.3 2 0 0 2 2 2 1 Inhibitor of sigma-G Gin zf-DNL PF05180.7 KII64122.1 - 0.017 14.8 0.6 0.12 12.0 0.0 2.2 2 0 0 2 2 2 0 DNL zinc finger DUF2039 PF10217.4 KII64122.1 - 0.069 13.1 0.7 2.1 8.4 0.0 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2039) zf-B_box PF00643.19 KII64122.1 - 0.24 11.2 2.4 5 7.0 0.1 2.6 2 0 0 2 2 2 0 B-box zinc finger Elf1 PF05129.8 KII64122.1 - 0.53 10.0 3.5 2.2 8.0 0.2 2.2 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-CHY PF05495.7 KII64122.1 - 0.62 10.2 4.5 5.6 7.2 3.1 2.1 1 1 0 1 1 1 0 CHY zinc finger Peptidase_S46 PF10459.4 KII64123.1 - 0.0049 15.3 7.1 0.005 15.3 4.9 1.2 1 0 0 1 1 1 1 Peptidase S46 DUF382 PF04037.8 KII64123.1 - 0.014 15.1 8.9 0.042 13.6 1.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF382) ACCA PF03255.9 KII64123.1 - 0.015 14.8 7.7 0.68 9.4 1.2 2.1 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ScpA_ScpB PF02616.9 KII64123.1 - 0.053 13.0 12.0 0.059 12.9 8.3 1.0 1 0 0 1 1 1 0 ScpA/B protein Condensation PF00668.15 KII64123.1 - 0.054 12.3 3.1 0.084 11.6 2.1 1.2 1 0 0 1 1 1 0 Condensation domain DUF3437 PF11919.3 KII64123.1 - 0.055 13.1 1.5 0.93 9.2 0.9 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3437) Clathrin_lg_ch PF01086.12 KII64123.1 - 0.31 10.9 12.4 0.37 10.6 8.6 1.0 1 0 0 1 1 1 0 Clathrin light chain SpoVIF PF14069.1 KII64124.1 - 0.11 12.1 0.1 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Stage VI sporulation protein F Fez1 PF06818.10 KII64125.1 - 2.1e-05 24.6 4.4 2.9e-05 24.2 3.0 1.1 1 0 0 1 1 1 1 Fez1 Macoilin PF09726.4 KII64125.1 - 0.0049 15.2 6.5 0.0063 14.8 4.5 1.0 1 0 0 1 1 1 1 Transmembrane protein DUF3452 PF11934.3 KII64125.1 - 0.016 14.5 0.4 0.03 13.6 0.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) Wx5_PLAF3D7 PF09688.5 KII64125.1 - 0.019 14.9 5.8 0.064 13.2 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) IncA PF04156.9 KII64125.1 - 0.023 14.2 15.4 0.32 10.5 10.2 2.0 1 1 0 1 1 1 0 IncA protein ADIP PF11559.3 KII64125.1 - 0.025 14.5 8.2 0.12 12.3 0.6 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Tropomyosin PF00261.15 KII64125.1 - 0.039 13.0 9.3 0.037 13.1 0.8 2.0 2 0 0 2 2 2 0 Tropomyosin KLRAQ PF10205.4 KII64125.1 - 0.058 13.4 0.7 0.058 13.4 0.5 2.1 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Laminin_I PF06008.9 KII64125.1 - 0.059 12.6 8.1 0.15 11.3 0.6 2.1 2 0 0 2 2 2 0 Laminin Domain I PBP_dimer PF03717.10 KII64125.1 - 0.065 13.2 4.6 0.05 13.6 0.8 2.0 1 1 0 2 2 2 0 Penicillin-binding Protein dimerisation domain UBN2 PF14223.1 KII64125.1 - 0.089 12.5 0.3 0.089 12.5 0.2 2.4 2 1 1 3 3 3 0 gag-polypeptide of LTR copia-type Seryl_tRNA_N PF02403.17 KII64125.1 - 0.13 12.2 10.0 0.36 10.8 1.4 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin_1 PF12718.2 KII64125.1 - 0.16 11.8 11.5 0.2 11.5 1.5 2.2 2 0 0 2 2 2 0 Tropomyosin like APG17 PF04108.7 KII64125.1 - 0.17 10.6 8.3 0.49 9.1 5.8 1.6 1 1 0 1 1 1 0 Autophagy protein Apg17 Mga PF05043.8 KII64125.1 - 0.19 12.0 1.3 1.3 9.3 0.1 2.2 2 0 0 2 2 2 0 Mga helix-turn-helix domain DUF4559 PF15112.1 KII64125.1 - 0.21 10.6 5.5 0.28 10.3 3.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Transcrip_act PF04949.8 KII64125.1 - 0.25 10.9 4.0 0.8 9.3 2.4 1.9 1 1 0 1 1 1 0 Transcriptional activator BLOC1_2 PF10046.4 KII64125.1 - 0.29 11.2 6.5 2.1 8.5 0.3 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF16 PF01519.11 KII64125.1 - 0.41 10.8 5.3 0.56 10.4 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 Acyl-CoA_ox_N PF14749.1 KII64125.1 - 0.44 10.8 7.0 0.42 10.8 0.4 2.0 1 1 1 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Fib_alpha PF08702.5 KII64125.1 - 0.48 10.5 6.0 3 7.9 0.6 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Cortex-I_coil PF09304.5 KII64125.1 - 0.49 10.4 10.4 1.3 9.1 0.6 2.6 2 1 0 2 2 2 0 Cortexillin I, coiled coil DUF3734 PF12536.3 KII64125.1 - 0.55 10.3 3.1 14 5.8 0.1 2.1 2 0 0 2 2 2 0 Patatin phospholipase ATG16 PF08614.6 KII64125.1 - 0.77 9.5 14.2 0.15 11.8 3.0 2.0 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) PspA_IM30 PF04012.7 KII64125.1 - 0.91 8.8 9.7 0.55 9.5 1.3 2.1 2 0 0 2 2 2 0 PspA/IM30 family DUF848 PF05852.6 KII64125.1 - 1.1 9.1 12.4 0.44 10.3 1.6 2.0 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Spc7 PF08317.6 KII64125.1 - 1.1 7.8 12.4 3.7 6.1 8.7 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein CALCOCO1 PF07888.6 KII64125.1 - 1.5 7.0 10.5 9.2 4.4 7.2 1.8 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Cep57_MT_bd PF06657.8 KII64125.1 - 1.9 8.5 7.1 0.88 9.5 0.3 3.0 2 2 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF3338 PF11819.3 KII64125.1 - 1.9 7.9 5.3 0.65 9.4 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) DUF1409 PF07197.7 KII64125.1 - 1.9 8.6 4.9 12 6.0 1.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1409) DUF3450 PF11932.3 KII64125.1 - 1.9 7.6 8.6 4 6.6 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) MitMem_reg PF13012.1 KII64125.1 - 2 8.5 6.1 3 7.9 1.0 2.1 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function Jnk-SapK_ap_N PF09744.4 KII64125.1 - 2.1 8.3 8.9 2.4 8.1 0.4 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Baculo_PEP_C PF04513.7 KII64125.1 - 2.2 8.1 6.0 3 7.6 0.2 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Med28 PF11594.3 KII64125.1 - 2.2 8.5 9.1 8.3 6.7 1.7 2.1 2 0 0 2 2 2 0 Mediator complex subunit 28 zf-ZPR1 PF03367.8 KII64125.1 - 2.7 7.1 6.8 0.84 8.7 0.5 2.0 1 1 0 2 2 2 0 ZPR1 zinc-finger domain NYD-SP28 PF14772.1 KII64125.1 - 3.1 7.9 8.6 2.2 8.4 2.6 2.1 1 1 1 2 2 2 0 Sperm tail Cauli_AT PF03233.8 KII64125.1 - 3.5 7.3 8.8 9.3 5.9 0.6 2.1 1 1 1 2 2 2 0 Aphid transmission protein Nup54 PF13874.1 KII64125.1 - 3.5 7.2 7.1 1.1 8.8 0.4 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 CENP-F_N PF10481.4 KII64125.1 - 3.8 6.7 11.8 1.5 8.1 1.8 2.5 1 1 1 2 2 2 0 Cenp-F N-terminal domain Uso1_p115_C PF04871.8 KII64125.1 - 3.9 7.4 10.5 9.7 6.1 7.3 1.7 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Med4 PF10018.4 KII64125.1 - 4 6.8 12.8 3.9 6.8 2.0 2.2 1 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Bap31 PF05529.7 KII64125.1 - 4.2 6.7 9.3 2.1 7.7 0.8 2.0 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like DUF4200 PF13863.1 KII64125.1 - 4.4 7.2 12.0 7.2 6.5 2.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) TPR_MLP1_2 PF07926.7 KII64125.1 - 5.2 6.8 13.7 14 5.3 9.5 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein FliD_C PF07195.7 KII64125.1 - 6.8 5.9 10.2 43 3.2 7.1 1.8 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus IATP PF04568.7 KII64125.1 - 7.2 6.7 8.7 0.33 10.9 1.4 2.0 2 1 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP TMPIT PF07851.8 KII64125.1 - 7.4 5.5 10.2 8.4 5.3 0.9 2.0 1 1 1 2 2 2 0 TMPIT-like protein bZIP_1 PF00170.16 KII64125.1 - 7.9 6.5 13.0 6.6 6.7 0.9 2.5 2 1 0 2 2 2 0 bZIP transcription factor AAA_13 PF13166.1 KII64125.1 - 8.6 4.6 12.1 6.9 4.9 2.5 1.6 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KII64125.1 - 9.8 6.4 16.6 18 5.5 11.5 1.4 1 1 0 1 1 1 0 AAA domain RVT_1 PF00078.22 KII64129.1 - 5.9e-30 104.2 0.1 1.8e-29 102.6 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII64129.1 - 1.1e-25 90.0 0.0 3.2e-25 88.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII64129.1 - 2.8e-06 27.1 0.0 8.4e-06 25.6 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII64129.1 - 0.00065 19.5 0.9 0.0013 18.5 0.6 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.5 KII64129.1 - 0.0017 17.7 0.2 0.0097 15.2 0.0 2.3 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII64129.1 - 0.0076 15.7 5.7 0.081 12.4 0.0 2.9 3 0 0 3 3 3 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII64129.1 - 0.015 15.3 0.0 0.051 13.5 0.0 1.9 1 0 0 1 1 1 0 DDE domain Asp_protease_2 PF13650.1 KII64129.1 - 0.031 14.7 0.0 0.078 13.4 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease Asp_protease PF09668.5 KII64129.1 - 0.065 12.8 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease IncA PF04156.9 KII64130.1 - 0.0035 16.9 4.5 0.0042 16.6 3.1 1.1 1 0 0 1 1 1 1 IncA protein YkyA PF10368.4 KII64130.1 - 0.0046 16.3 2.5 0.06 12.6 0.3 2.1 2 0 0 2 2 2 1 Putative cell-wall binding lipoprotein DivIC PF04977.10 KII64130.1 - 0.014 14.8 4.6 0.051 13.0 0.1 2.4 2 1 0 2 2 2 0 Septum formation initiator EzrA PF06160.7 KII64130.1 - 0.038 12.1 3.8 0.14 10.3 0.8 1.9 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA bZIP_1 PF00170.16 KII64130.1 - 0.039 13.9 0.3 0.039 13.9 0.2 2.6 2 1 0 2 2 2 0 bZIP transcription factor GrpE PF01025.14 KII64130.1 - 0.041 13.4 3.9 0.33 10.4 0.6 2.0 2 0 0 2 2 2 0 GrpE BLOC1_2 PF10046.4 KII64130.1 - 0.08 13.0 5.3 0.17 12.0 1.7 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Seryl_tRNA_N PF02403.17 KII64130.1 - 0.089 12.8 4.7 0.16 11.9 3.2 1.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF3510 PF12022.3 KII64130.1 - 0.09 12.8 0.9 0.11 12.5 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) KLRAQ PF10205.4 KII64130.1 - 0.11 12.5 2.7 7.1 6.7 0.7 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DUF2935 PF11155.3 KII64130.1 - 0.12 12.4 0.6 0.17 11.9 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) PPP4R2 PF09184.6 KII64130.1 - 0.12 11.9 1.1 0.12 11.8 0.7 1.1 1 0 0 1 1 1 0 PPP4R2 ALIX_LYPXL_bnd PF13949.1 KII64130.1 - 0.15 11.0 5.3 0.61 8.9 3.6 1.8 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV CCDC155 PF14662.1 KII64130.1 - 0.19 11.2 3.5 0.39 10.2 2.5 1.4 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 Prefoldin PF02996.12 KII64130.1 - 0.28 10.8 6.1 0.7 9.5 0.5 2.2 1 1 2 3 3 3 0 Prefoldin subunit ATG16 PF08614.6 KII64130.1 - 0.47 10.2 6.0 3.7 7.3 0.1 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.3 KII64130.1 - 0.55 9.9 6.3 8.4 6.1 0.1 2.4 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Phage_GP20 PF06810.6 KII64130.1 - 0.84 9.0 7.0 17 4.8 4.2 2.0 1 1 0 1 1 1 0 Phage minor structural protein GP20 HALZ PF02183.13 KII64130.1 - 1.3 8.7 4.0 0.78 9.4 0.4 2.3 2 1 1 3 3 3 0 Homeobox associated leucine zipper DUF972 PF06156.8 KII64130.1 - 1.4 9.2 4.0 8.8 6.7 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF4200 PF13863.1 KII64130.1 - 1.6 8.6 9.7 6.7 6.6 6.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) PhoU PF01895.14 KII64130.1 - 2.2 8.7 5.7 9.7 6.7 1.6 2.1 2 0 0 2 2 2 0 PhoU domain DivIVA PF05103.8 KII64130.1 - 2.8 7.9 7.4 16 5.5 1.9 2.2 1 1 1 2 2 2 0 DivIVA protein DDE_3 PF13358.1 KII64131.1 - 2.8e-18 66.0 0.0 6.6e-17 61.6 0.0 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII64131.1 - 0.0064 16.5 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Transposase DDE_1 PF03184.14 KII64131.1 - 0.03 13.4 0.1 0.14 11.2 0.0 2.0 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_32 PF13565.1 KII64131.1 - 0.14 12.9 0.0 0.7 10.7 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain EzrA PF06160.7 KII64133.1 - 5.1e-05 21.6 7.6 7e-05 21.2 5.3 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA ALIX_LYPXL_bnd PF13949.1 KII64133.1 - 8.6e-05 21.6 4.5 0.00013 21.0 3.1 1.3 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV CENP-F_leu_zip PF10473.4 KII64133.1 - 0.00012 21.9 8.3 0.0017 18.2 0.9 2.1 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1192 PF06698.6 KII64133.1 - 0.0002 21.0 3.3 0.0019 17.9 0.2 2.6 3 0 0 3 3 2 1 Protein of unknown function (DUF1192) FH2 PF02181.18 KII64133.1 - 0.00022 20.2 6.6 0.0017 17.2 1.8 2.0 1 1 1 2 2 2 1 Formin Homology 2 Domain Filament PF00038.16 KII64133.1 - 0.00026 20.5 7.7 0.035 13.5 1.9 2.0 1 1 1 2 2 2 2 Intermediate filament protein Med9 PF07544.8 KII64133.1 - 0.00036 20.2 11.5 0.0045 16.6 0.4 3.0 2 1 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 CALCOCO1 PF07888.6 KII64133.1 - 0.00074 17.9 3.7 0.00092 17.6 2.5 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Seryl_tRNA_N PF02403.17 KII64133.1 - 0.0011 19.0 9.3 0.085 12.8 2.9 2.4 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain GrpE PF01025.14 KII64133.1 - 0.0012 18.4 4.7 0.0016 17.9 3.2 1.2 1 0 0 1 1 1 1 GrpE GAS PF13851.1 KII64133.1 - 0.0016 17.7 11.9 0.0084 15.3 7.9 1.9 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding FlxA PF14282.1 KII64133.1 - 0.0022 17.8 3.6 0.0022 17.8 2.5 2.2 1 1 0 2 2 2 1 FlxA-like protein Spc7 PF08317.6 KII64133.1 - 0.0023 16.6 9.3 0.0031 16.2 6.5 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Reo_sigmaC PF04582.7 KII64133.1 - 0.0029 16.8 0.2 0.057 12.5 0.0 1.9 1 1 1 2 2 2 1 Reovirus sigma C capsid protein AAA_13 PF13166.1 KII64133.1 - 0.0032 16.0 10.6 0.0048 15.4 7.3 1.3 1 0 0 1 1 1 1 AAA domain DUF2682 PF10909.3 KII64133.1 - 0.0047 17.1 0.7 0.0047 17.1 0.5 1.8 2 0 0 2 2 1 1 Protein of unknown function (DUF2682) BLOC1_2 PF10046.4 KII64133.1 - 0.0048 17.0 10.7 0.052 13.6 1.9 2.5 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.9 KII64133.1 - 0.0049 16.4 10.5 0.089 12.3 7.3 2.0 1 1 0 1 1 1 1 IncA protein Prefoldin PF02996.12 KII64133.1 - 0.0061 16.1 13.8 1 9.0 0.2 3.1 3 0 0 3 3 3 1 Prefoldin subunit LXG PF04740.7 KII64133.1 - 0.0068 16.2 12.0 0.08 12.7 3.3 2.1 1 1 1 2 2 2 1 LXG domain of WXG superfamily Vps51 PF08700.6 KII64133.1 - 0.0073 16.1 6.4 0.27 11.0 0.2 3.1 3 0 0 3 3 3 1 Vps51/Vps67 Med10 PF09748.4 KII64133.1 - 0.0077 16.0 2.8 0.036 13.8 0.5 2.0 2 0 0 2 2 2 1 Transcription factor subunit Med10 of Mediator complex DUF948 PF06103.6 KII64133.1 - 0.0093 15.8 5.2 1.2 9.0 0.2 2.9 2 1 0 2 2 2 1 Bacterial protein of unknown function (DUF948) DUF4618 PF15397.1 KII64133.1 - 0.0097 15.2 10.9 1.8 7.8 0.1 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4618) Zw10 PF06248.8 KII64133.1 - 0.0098 14.1 6.9 0.016 13.3 4.8 1.4 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 DUF2353 PF09789.4 KII64133.1 - 0.0098 15.1 8.6 0.051 12.8 1.9 2.0 1 1 1 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) Bcr-Abl_Oligo PF09036.5 KII64133.1 - 0.011 15.6 5.5 0.35 10.8 0.1 2.9 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain HR1 PF02185.11 KII64133.1 - 0.012 15.3 10.5 0.013 15.2 0.2 3.2 3 0 0 3 3 3 0 Hr1 repeat DUF4140 PF13600.1 KII64133.1 - 0.014 15.8 5.9 0.15 12.5 0.2 2.8 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.10 KII64133.1 - 0.015 14.7 16.3 0.16 11.4 1.4 3.2 1 1 2 3 3 3 0 Septum formation initiator DUF4600 PF15372.1 KII64133.1 - 0.019 15.1 10.6 0.14 12.3 3.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) Lebercilin PF15619.1 KII64133.1 - 0.025 14.0 9.4 0.044 13.1 6.5 1.5 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease TMPIT PF07851.8 KII64133.1 - 0.026 13.5 6.4 0.032 13.2 4.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein TBPIP PF07106.8 KII64133.1 - 0.027 14.0 15.8 0.038 13.5 4.3 2.4 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TPR_MLP1_2 PF07926.7 KII64133.1 - 0.031 14.0 10.6 0.074 12.7 7.3 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4200 PF13863.1 KII64133.1 - 0.044 13.7 18.3 0.72 9.8 1.2 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Ax_dynein_light PF10211.4 KII64133.1 - 0.045 13.5 11.2 0.15 11.9 1.7 2.2 2 0 0 2 2 2 0 Axonemal dynein light chain DUF4201 PF13870.1 KII64133.1 - 0.052 12.9 12.2 0.53 9.7 3.8 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Peptidase_C65 PF10275.4 KII64133.1 - 0.054 12.8 7.5 0.034 13.4 2.5 1.9 1 1 1 2 2 2 0 Peptidase C65 Otubain Orthopox_A5L PF06193.6 KII64133.1 - 0.06 13.2 8.9 0.14 12.0 6.2 1.6 1 1 0 1 1 1 0 Orthopoxvirus A5L protein-like TMF_DNA_bd PF12329.3 KII64133.1 - 0.06 13.1 16.5 0.23 11.2 0.4 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.3 KII64133.1 - 0.061 13.2 9.9 0.25 11.2 2.2 2.1 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Laminin_I PF06008.9 KII64133.1 - 0.064 12.5 7.8 0.23 10.7 5.4 1.7 1 1 0 1 1 1 0 Laminin Domain I Baculo_PEP_C PF04513.7 KII64133.1 - 0.067 13.0 4.2 0.46 10.3 0.5 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MCH PF02289.11 KII64133.1 - 0.071 12.1 0.0 0.079 11.9 0.0 1.1 1 0 0 1 1 1 0 Cyclohydrolase (MCH) DUF211 PF02680.9 KII64133.1 - 0.072 12.8 0.4 0.16 11.8 0.3 1.7 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 Complex1_LYR_2 PF13233.1 KII64133.1 - 0.081 13.4 1.1 0.11 12.9 0.7 1.3 1 0 0 1 1 1 0 Complex1_LYR-like APG6 PF04111.7 KII64133.1 - 0.088 11.8 9.0 0.16 10.9 6.2 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 HalX PF08663.5 KII64133.1 - 0.092 12.7 1.3 27 4.8 0.0 3.1 3 0 0 3 3 3 0 HalX domain Laminin_II PF06009.7 KII64133.1 - 0.1 12.3 7.6 0.43 10.3 2.0 2.3 1 1 1 2 2 2 0 Laminin Domain II TcdB_N PF12918.2 KII64133.1 - 0.1 12.6 1.0 0.1 12.6 0.7 3.0 3 0 0 3 3 3 0 TcdB toxin N-terminal helical domain LysM PF01476.15 KII64133.1 - 0.11 12.4 0.1 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 LysM domain DUF3450 PF11932.3 KII64133.1 - 0.11 11.6 7.3 0.043 13.0 1.1 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) Tropomyosin_1 PF12718.2 KII64133.1 - 0.12 12.2 14.4 0.79 9.5 1.6 2.7 2 1 0 2 2 2 0 Tropomyosin like Tropomyosin PF00261.15 KII64133.1 - 0.13 11.3 10.2 1.4 7.9 2.4 2.1 1 1 0 2 2 2 0 Tropomyosin MscS_porin PF12795.2 KII64133.1 - 0.13 11.5 7.9 1.3 8.2 5.4 2.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain FliJ PF02050.11 KII64133.1 - 0.14 12.2 9.5 0.25 11.4 2.0 2.5 1 1 0 2 2 2 0 Flagellar FliJ protein DMPK_coil PF08826.5 KII64133.1 - 0.14 12.0 10.4 2.2 8.2 0.3 3.1 3 0 0 3 3 3 0 DMPK coiled coil domain like DUF342 PF03961.8 KII64133.1 - 0.16 10.3 14.7 4.6 5.5 10.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Prefoldin_2 PF01920.15 KII64133.1 - 0.16 11.7 18.6 0.88 9.3 1.2 3.1 2 1 1 3 3 3 0 Prefoldin subunit DUF869 PF05911.6 KII64133.1 - 0.17 10.1 8.4 0.3 9.2 1.3 1.7 1 1 0 1 1 1 0 Plant protein of unknown function (DUF869) DUF1319 PF07028.6 KII64133.1 - 0.17 12.0 13.1 0.36 11.0 0.5 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1319) THOC7 PF05615.8 KII64133.1 - 0.17 12.1 13.8 0.12 12.5 2.9 2.6 1 1 1 2 2 2 0 Tho complex subunit 7 DUF4164 PF13747.1 KII64133.1 - 0.19 11.9 4.2 0.99 9.5 0.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) DUF972 PF06156.8 KII64133.1 - 0.22 11.8 10.1 1.7 9.0 0.5 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF972) DASH_Dam1 PF08653.5 KII64133.1 - 0.25 11.1 2.4 20 5.0 0.0 2.9 2 2 1 3 3 3 0 DASH complex subunit Dam1 Katanin_con80 PF13925.1 KII64133.1 - 0.29 10.8 3.1 0.25 11.0 0.9 1.7 1 1 1 2 2 2 0 con80 domain of Katanin DUF641 PF04859.7 KII64133.1 - 0.29 10.8 4.4 0.45 10.2 0.2 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Tnp_P_element PF12017.3 KII64133.1 - 0.32 10.1 7.8 0.14 11.4 1.3 2.3 1 1 0 2 2 2 0 Transposase protein PAH PF02671.16 KII64133.1 - 0.33 10.6 3.0 0.25 10.9 0.4 2.1 2 0 0 2 2 1 0 Paired amphipathic helix repeat Fib_alpha PF08702.5 KII64133.1 - 0.34 11.0 13.4 0.63 10.1 0.7 3.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Med11 PF10280.4 KII64133.1 - 0.36 10.8 5.2 3.2 7.8 3.5 2.4 1 1 0 1 1 1 0 Mediator complex protein Zein-binding PF04576.10 KII64133.1 - 0.36 10.9 5.1 1 9.5 0.2 2.2 2 0 0 2 2 2 0 Zein-binding XkdW PF09636.5 KII64133.1 - 0.37 10.6 9.7 0.94 9.3 0.7 2.9 2 1 1 3 3 3 0 XkdW protein Snapin_Pallidin PF14712.1 KII64133.1 - 0.38 11.0 10.5 1.6 9.0 0.7 2.5 1 1 1 2 2 2 0 Snapin/Pallidin Toxin_52 PF15605.1 KII64133.1 - 0.4 10.5 3.1 1.7 8.5 0.2 2.2 1 1 1 2 2 2 0 Putative toxin 52 FlaC_arch PF05377.6 KII64133.1 - 0.41 10.5 16.6 2.4 8.1 1.7 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1843 PF08898.5 KII64133.1 - 0.44 10.6 2.4 56 3.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) AHH PF14412.1 KII64133.1 - 0.46 10.4 5.5 3 7.8 0.6 2.8 2 1 1 3 3 3 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Adeno_PIX PF03955.9 KII64133.1 - 0.61 10.6 2.0 9.1 6.8 0.0 2.6 2 1 1 3 3 3 0 Adenovirus hexon-associated protein (IX) Sugarporin_N PF11471.3 KII64133.1 - 0.61 9.7 14.0 0.096 12.3 1.8 2.3 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Snf7 PF03357.16 KII64133.1 - 0.62 9.4 16.4 0.3 10.4 0.3 2.7 2 1 0 2 2 2 0 Snf7 BDV_P24 PF06595.6 KII64133.1 - 0.63 9.7 3.7 1.1 9.0 2.6 1.5 1 1 0 1 1 1 0 Borna disease virus P24 protein NPV_P10 PF05531.7 KII64133.1 - 0.64 10.3 7.2 4 7.7 1.3 3.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein YlqD PF11068.3 KII64133.1 - 0.65 10.0 9.9 2.5 8.1 2.5 2.1 1 1 1 2 2 2 0 YlqD protein DUF1664 PF07889.7 KII64133.1 - 0.71 9.6 10.1 1.6 8.5 1.7 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) CCDC-167 PF15188.1 KII64133.1 - 0.82 9.6 10.9 1.1 9.2 3.1 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 V-SNARE PF05008.10 KII64133.1 - 0.9 9.7 13.6 1.2 9.3 0.7 2.7 1 1 2 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF3740 PF12548.3 KII64133.1 - 0.93 9.7 13.7 4.5 7.5 0.2 3.4 3 1 1 4 4 4 0 Sulfatase protein DUF3166 PF11365.3 KII64133.1 - 0.95 9.9 10.4 5.3 7.5 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3166) TFR_dimer PF04253.10 KII64133.1 - 1 8.9 3.7 26 4.3 0.0 2.9 2 1 1 3 3 3 0 Transferrin receptor-like dimerisation domain GreA_GreB_N PF03449.10 KII64133.1 - 1.1 9.3 9.8 2.2 8.3 0.2 3.3 3 1 0 3 3 3 0 Transcription elongation factor, N-terminal EMP24_GP25L PF01105.19 KII64133.1 - 1.3 8.7 9.1 1.9 8.2 1.7 2.4 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD PspA_IM30 PF04012.7 KII64133.1 - 1.3 8.3 7.4 4.5 6.5 0.4 2.4 2 1 0 2 2 2 0 PspA/IM30 family Mitofilin PF09731.4 KII64133.1 - 1.8 7.0 10.5 4.5 5.7 7.3 1.6 1 1 0 1 1 1 0 Mitochondrial inner membrane protein DUF2115 PF09888.4 KII64133.1 - 2 8.5 6.4 2 8.4 1.5 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) DUF2802 PF10975.3 KII64133.1 - 2.5 7.9 5.3 5.5 6.8 0.1 2.9 3 1 0 3 3 2 0 Protein of unknown function (DUF2802) DUF904 PF06005.7 KII64133.1 - 2.6 8.3 13.1 5.7 7.3 0.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Syntaxin-6_N PF09177.6 KII64133.1 - 2.7 8.4 9.3 6.8 7.1 2.3 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DivIVA PF05103.8 KII64133.1 - 2.7 8.0 13.7 26 4.8 0.7 2.9 1 1 1 2 2 2 0 DivIVA protein DUF2205 PF10224.4 KII64133.1 - 3 7.4 8.9 1.4 8.5 0.2 2.7 3 1 0 3 3 2 0 Predicted coiled-coil protein (DUF2205) XhlA PF10779.4 KII64133.1 - 3.4 7.6 17.7 2.3 8.2 0.9 3.2 2 1 1 3 3 3 0 Haemolysin XhlA bZIP_1 PF00170.16 KII64133.1 - 4.1 7.4 15.4 3.7 7.5 1.1 3.2 2 1 1 3 3 3 0 bZIP transcription factor GP41 PF00517.12 KII64133.1 - 4.2 6.8 10.2 1.9e+03 -1.8 7.1 3.0 1 1 0 1 1 0 0 Retroviral envelope protein SlyX PF04102.7 KII64133.1 - 4.5 7.7 8.4 2.7 8.4 2.2 2.5 2 1 0 2 2 2 0 SlyX Streptin-Immun PF11083.3 KII64133.1 - 4.5 7.3 11.3 15 5.6 3.2 3.0 1 1 2 3 3 3 0 Lantibiotic streptin immunity protein V_ATPase_I PF01496.14 KII64133.1 - 4.5 4.9 9.6 2.8 5.6 1.4 1.8 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Val_tRNA-synt_C PF10458.4 KII64133.1 - 4.8 7.3 11.2 21 5.2 0.0 3.1 3 0 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm Occludin_ELL PF07303.8 KII64133.1 - 5.2 7.8 10.4 4.7 8.0 1.4 2.3 1 1 1 2 2 2 0 Occludin homology domain DUF848 PF05852.6 KII64133.1 - 5.5 6.8 8.9 1.1 9.1 1.2 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) bZIP_2 PF07716.10 KII64133.1 - 5.9 6.7 15.1 0.58 10.0 1.5 2.9 2 1 1 3 3 3 0 Basic region leucine zipper Kinetocho_Slk19 PF12709.2 KII64133.1 - 6 7.0 12.6 7.5 6.7 0.7 3.0 2 1 1 3 3 3 0 Central kinetochore-associated TMF_TATA_bd PF12325.3 KII64133.1 - 6 6.6 11.2 11 5.8 3.0 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4404 PF14357.1 KII64133.1 - 6.1 7.3 7.2 16 5.9 0.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) KLRAQ PF10205.4 KII64133.1 - 6.2 6.9 8.2 3.6 7.6 0.6 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein LRR_4 PF12799.2 KII64133.1 - 6.3 6.5 8.9 13 5.5 1.9 3.6 3 2 0 3 3 2 0 Leucine Rich repeats (2 copies) MtrG PF04210.8 KII64133.1 - 6.5 6.5 5.9 3.6 7.3 0.1 2.8 1 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF2951 PF11166.3 KII64133.1 - 6.7 6.6 12.1 12 5.8 3.7 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) DUF3573 PF12097.3 KII64133.1 - 7.2 5.1 8.6 3.9 5.9 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) BRE1 PF08647.6 KII64133.1 - 7.4 6.6 11.2 11 6.0 0.1 2.9 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase ATG16 PF08614.6 KII64133.1 - 7.5 6.3 12.4 1.1 9.0 2.8 2.2 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) MbeB_N PF04837.7 KII64133.1 - 8.4 6.5 10.7 1.1 9.4 2.0 2.9 3 0 0 3 3 3 0 MbeB-like, N-term conserved region Med4 PF10018.4 KII64133.1 - 8.9 5.6 11.0 4 6.7 1.8 2.6 1 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 YbjN PF10722.4 KII64136.1 - 0.065 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative bacterial sensory transduction regulator ArsC PF03960.10 KII64137.1 - 4.5e-29 100.7 0.0 5.4e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 ArsC family HGD-D PF06050.8 KII64137.1 - 0.038 12.8 0.0 0.07 11.9 0.0 1.6 1 1 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Glutaredoxin PF00462.19 KII64137.1 - 0.041 13.8 0.0 0.51 10.3 0.0 2.1 1 1 1 2 2 2 0 Glutaredoxin PGM_PMM_IV PF00408.15 KII64137.1 - 0.061 13.3 0.4 0.82 9.7 0.0 2.5 2 1 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain ArsB PF02040.10 KII64138.1 - 5.4e-125 417.6 13.8 6.1e-125 417.4 9.6 1.0 1 0 0 1 1 1 1 Arsenical pump membrane protein CitMHS PF03600.11 KII64138.1 - 8e-06 24.6 10.6 1.3e-05 24.0 7.3 1.3 1 0 0 1 1 1 1 Citrate transporter TctB PF07331.6 KII64138.1 - 0.0058 16.2 6.2 0.0058 16.2 4.3 2.2 2 1 0 2 2 2 1 Tripartite tricarboxylate transporter TctB family CagE_TrbE_VirB PF03135.9 KII64138.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system Oxidored_q1_N PF00662.15 KII64138.1 - 0.34 10.5 2.1 1 8.9 1.4 1.8 1 0 0 1 1 1 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus FMN_red PF03358.10 KII64140.1 - 3.3e-29 101.3 0.0 4.6e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 KII64140.1 - 8.1e-05 22.2 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin-like fold PilI PF10623.4 KII64142.1 - 0.43 10.5 2.0 7.3 6.6 0.2 2.5 2 0 0 2 2 2 0 Plasmid conjugative transfer protein PilI DUF3505 PF12013.3 KII64143.1 - 0.00032 20.9 4.8 0.061 13.5 0.2 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF3505) zf-H2C2_2 PF13465.1 KII64143.1 - 0.00043 20.4 13.3 0.0015 18.7 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII64143.1 - 0.0071 16.5 17.2 0.72 10.3 0.1 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.7 KII64143.1 - 0.011 15.9 0.1 0.011 15.9 0.0 2.8 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-TRAF PF02176.13 KII64143.1 - 0.021 15.2 4.3 0.021 15.2 3.0 3.2 2 1 1 3 3 3 0 TRAF-type zinc finger zf-H2C2_5 PF13909.1 KII64143.1 - 0.066 13.4 0.3 0.066 13.4 0.2 3.9 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.21 KII64143.1 - 0.076 13.3 17.9 0.16 12.3 0.3 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-met PF12874.2 KII64143.1 - 1.4 9.2 7.2 12 6.2 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 KII64144.1 - 0.015 15.5 10.4 0.11 12.8 0.2 2.6 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII64144.1 - 0.2 12.0 9.6 0.44 11.0 1.5 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Casc1 PF12366.3 KII64145.1 - 0.075 12.5 3.9 0.1 12.0 2.7 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 VirDNA-topo-I_N PF09266.5 KII64145.1 - 0.11 12.3 1.3 0.33 10.8 0.1 2.4 3 0 0 3 3 3 0 Viral DNA topoisomerase I, N-terminal Serpin PF00079.15 KII64148.1 - 6.4e-56 190.0 3.0 7.2e-56 189.9 2.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) bPH_4 PF06713.6 KII64149.1 - 0.72 9.7 5.0 0.14 12.0 0.5 2.0 2 0 0 2 2 2 0 Bacterial PH domain Serpin PF00079.15 KII64150.1 - 2.9e-21 76.0 0.2 3.3e-21 75.8 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3796 PF12676.2 KII64156.1 - 0.035 14.3 1.3 0.059 13.6 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3796) SpoVS PF04232.7 KII64157.1 - 0.13 11.8 0.1 0.19 11.3 0.1 1.2 1 0 0 1 1 1 0 Stage V sporulation protein S (SpoVS) TFIID-31kDa PF02291.10 KII64161.1 - 1e-14 54.4 0.0 1.4e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit PocR PF10114.4 KII64162.1 - 0.0026 16.9 0.6 0.012 14.7 0.0 2.2 1 1 2 3 3 3 1 Sensory domain found in PocR DDE_Tnp_IS1595 PF12762.2 KII64164.1 - 0.00029 20.7 0.1 0.00034 20.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain HeH PF12949.2 KII64164.1 - 0.16 11.5 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 HeH/LEM domain Ribosomal_S6e PF01092.14 KII64165.1 - 5.5e-12 45.4 0.0 7.5e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6e Androgen_recep PF02166.11 KII64165.1 - 0.033 13.0 0.0 0.035 12.9 0.0 1.1 1 0 0 1 1 1 0 Androgen receptor SNAP PF14938.1 KII64168.1 - 9.5e-05 21.6 0.1 0.00011 21.4 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR PF01535.15 KII64168.1 - 0.052 13.5 0.3 0.51 10.4 0.0 2.6 3 0 0 3 3 3 0 PPR repeat TPR_8 PF13181.1 KII64168.1 - 0.19 11.5 0.9 9.4 6.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII64168.1 - 2.8 7.7 4.4 8.6 6.1 0.0 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Eaf7 PF07904.8 KII64170.1 - 0.0083 16.0 12.1 2 8.4 0.1 3.8 1 1 2 3 3 3 3 Chromatin modification-related protein EAF7 PH PF00169.24 KII64172.1 - 2.1e-06 27.8 3.1 4.7e-06 26.7 0.3 2.3 2 0 0 2 2 2 1 PH domain PH_4 PF15404.1 KII64172.1 - 0.00057 19.4 3.5 0.046 13.2 0.2 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.1 KII64172.1 - 0.024 14.8 1.2 0.41 10.9 0.8 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.1 KII64172.1 - 0.23 11.6 2.1 0.82 9.8 0.2 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain Ded_cyto PF06920.8 KII64173.1 - 1.8e-18 66.4 0.0 4e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Dedicator of cytokinesis UCR_14kD PF02271.11 KII64178.1 - 2.8e-10 39.9 0.0 3.1e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit CARDB PF07705.6 KII64179.1 - 0.076 13.0 0.0 0.28 11.2 0.0 1.8 1 1 1 2 2 2 0 CARDB DUF4427 PF14468.1 KII64180.1 - 0.013 15.2 0.2 0.11 12.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4427) rve PF00665.21 KII64181.1 - 1.6e-22 79.8 0.0 2.6e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII64181.1 - 0.00015 21.1 0.2 0.0016 17.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain rve PF00665.21 KII64182.1 - 9.1e-29 100.0 0.0 1.5e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII64182.1 - 0.00025 21.0 0.3 0.001 19.0 0.0 1.9 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII64182.1 - 0.0037 16.7 0.0 0.0089 15.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF4522 PF15022.1 KII64182.1 - 0.059 13.0 0.1 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) Mago-bind PF09282.5 KII64183.1 - 3e-10 39.4 0.5 5.8e-10 38.5 0.3 1.5 1 0 0 1 1 1 1 Mago binding Integrin_beta PF00362.13 KII64185.1 - 0.096 11.5 0.0 0.096 11.5 0.0 1.1 1 0 0 1 1 1 0 Integrin, beta chain EGF_2 PF07974.8 KII64186.1 - 0.0067 16.5 11.2 0.0067 16.5 7.8 2.8 2 1 1 3 3 3 1 EGF-like domain Integrin_beta PF00362.13 KII64188.1 - 1e-22 80.6 1.2 1.7e-22 79.9 0.8 1.3 1 0 0 1 1 1 1 Integrin, beta chain EGF_2 PF07974.8 KII64188.1 - 4e-07 30.0 58.2 2.4e-05 24.4 11.0 4.2 3 0 0 3 3 3 2 EGF-like domain DUF918 PF06033.6 KII64189.1 - 0.057 12.9 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF918) HEAT_EZ PF13513.1 KII64191.1 - 0.088 13.3 0.2 2.2 8.8 0.1 2.6 1 1 1 2 2 2 0 HEAT-like repeat RAM PF15320.1 KII64191.1 - 2.3 8.5 5.3 3.1 8.1 0.4 2.3 1 1 1 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein rve PF00665.21 KII64193.1 - 1.7e-25 89.4 0.0 3.4e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII64193.1 - 0.0022 17.4 0.1 0.01 15.3 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain BNR PF02012.15 KII64194.1 - 9.9e-06 24.6 1.9 0.23 11.4 0.2 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF2829 PF11195.3 KII64195.1 - 0.05 14.0 0.1 0.22 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2829) Complex1_51K PF01512.12 KII64197.1 - 0.15 11.8 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit Ribonuclease_3 PF00636.21 KII64200.1 - 0.0097 16.3 0.0 0.016 15.6 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease III domain Pkinase PF00069.20 KII64201.1 - 1.5e-19 70.1 0.4 2.7e-19 69.3 0.2 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII64201.1 - 1.2e-15 57.3 0.1 3.4e-15 55.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase DDE_1 PF03184.14 KII64202.1 - 6.4e-20 71.2 0.2 1.7e-19 69.8 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII64202.1 - 0.00016 21.3 0.3 0.0003 20.5 0.2 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Thaumatin PF00314.12 KII64202.1 - 0.018 14.4 0.2 0.021 14.2 0.1 1.1 1 0 0 1 1 1 0 Thaumatin family Thioredoxin_2 PF13098.1 KII64203.1 - 0.041 14.0 0.0 0.053 13.7 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain SNAP PF14938.1 KII64205.1 - 0.03 13.4 0.1 0.065 12.3 0.1 1.5 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP SNAP PF14938.1 KII64207.1 - 1.7e-08 33.9 0.0 2.6e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SNAP PF14938.1 KII64208.1 - 0.0042 16.2 0.6 0.0069 15.5 0.1 1.6 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP DehI PF10778.4 KII64208.1 - 0.028 13.9 0.1 0.05 13.1 0.1 1.4 1 0 0 1 1 1 0 Halocarboxylic acid dehydrogenase DehI COPI_C PF06957.6 KII64214.1 - 0.087 11.3 0.0 0.1 11.1 0.0 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus DUF4448 PF14610.1 KII64217.1 - 0.033 13.6 0.0 0.085 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) G-patch PF01585.18 KII64219.1 - 6.8e-09 35.3 0.7 1.7e-08 34.0 0.1 1.9 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.2 KII64219.1 - 0.0018 18.1 0.3 0.0029 17.4 0.2 1.4 1 1 0 1 1 1 1 DExH-box splicing factor binding site DnaJ PF00226.26 KII64221.1 - 1.9e-09 37.1 0.0 5.1e-09 35.7 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain DDE_3 PF13358.1 KII64222.1 - 5.4e-08 32.6 0.0 6.3e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4339 PF14237.1 KII64223.1 - 8.4e-10 38.0 2.0 9.8e-10 37.8 0.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4339) FHA PF00498.21 KII64225.1 - 4e-10 39.6 0.0 7.5e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain dsrm PF00035.20 KII64225.1 - 0.1 13.1 0.0 0.32 11.5 0.0 1.9 1 0 0 1 1 1 0 Double-stranded RNA binding motif Staygreen PF12638.2 KII64226.1 - 0.035 13.6 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Staygreen protein NifU_N PF01592.11 KII64230.1 - 2e-51 173.1 0.3 2.4e-51 172.9 0.2 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain Tho2 PF11262.3 KII64231.1 - 0.0068 15.4 1.5 0.012 14.7 1.0 1.5 1 1 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 RVT_1 PF00078.22 KII64232.1 - 0.00056 19.3 0.1 0.5 9.6 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.17 KII64233.1 - 8.3e-07 28.5 0.0 1.2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII64233.1 - 4.8e-06 26.3 0.0 6.8e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII64233.1 - 0.0064 16.4 0.0 0.021 14.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DDE_3 PF13358.1 KII64235.1 - 1.6e-16 60.4 0.2 3.4e-16 59.3 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII64235.1 - 8.9e-06 25.1 0.1 1.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII64235.1 - 0.0013 18.7 0.1 0.0021 18.0 0.1 1.3 1 0 0 1 1 1 1 Transposase HTH_17 PF12728.2 KII64235.1 - 0.0028 17.8 0.0 0.0075 16.4 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.1 KII64235.1 - 0.0063 16.6 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII64235.1 - 0.023 15.4 0.0 0.046 14.5 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Nuc_rec_co-act PF08815.5 KII64235.1 - 0.034 13.6 0.3 0.099 12.1 0.0 1.7 2 0 0 2 2 2 0 Nuclear receptor coactivator Peptidase_C97 PF05903.9 KII64235.1 - 0.1 12.3 0.1 6.1 6.6 0.0 2.2 1 1 0 2 2 2 0 PPPDE putative peptidase domain Peptidase_M15_2 PF05951.8 KII64236.1 - 0.056 12.8 0.1 0.61 9.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) zf-Sec23_Sec24 PF04810.10 KII64236.1 - 0.1 12.2 0.4 0.18 11.3 0.3 1.4 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Voltage_CLC PF00654.15 KII64237.1 - 2.9e-64 217.3 14.8 2.9e-64 217.3 10.3 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 KII64237.1 - 4.4e-06 26.3 0.4 6e-05 22.7 0.0 2.6 3 0 0 3 3 3 1 CBS domain MSC PF09402.5 KII64239.1 - 0.05 12.3 1.4 0.062 12.0 1.0 1.2 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain PEMT PF04191.8 KII64239.1 - 0.46 10.6 4.3 4.9 7.3 0.6 2.2 2 0 0 2 2 2 0 Phospholipid methyltransferase DUF3377 PF11857.3 KII64239.1 - 3.4 7.3 6.2 1.1 8.9 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DDE_3 PF13358.1 KII64240.1 - 2.8e-15 56.3 0.0 3e-13 49.7 0.0 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII64240.1 - 0.00089 18.7 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII64240.1 - 0.098 12.3 0.1 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain Myosin_head PF00063.16 KII64241.1 - 3.6e-124 415.3 0.0 4e-124 415.1 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.1 KII64241.1 - 0.00077 19.6 0.0 0.002 18.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.4 KII64241.1 - 0.0056 15.6 0.0 0.0095 14.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.1 KII64241.1 - 0.017 15.1 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain T2SE PF00437.15 KII64241.1 - 0.038 12.8 0.0 0.062 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 KII64241.1 - 0.059 13.6 0.1 0.48 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 KII64241.1 - 0.072 13.4 1.2 0.12 12.7 0.8 1.5 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KII64241.1 - 0.081 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain ABC_tran PF00005.22 KII64241.1 - 0.1 12.8 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.1 KII64241.1 - 0.16 12.8 0.7 5.4 7.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain Myosin_head PF00063.16 KII64242.1 - 1.7e-62 211.4 0.0 3.5e-62 210.4 0.0 1.5 1 1 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 KII64242.1 - 1.3e-28 99.6 3.2 2.3e-28 98.8 2.2 1.4 1 0 0 1 1 1 1 Myosin tail SH3_1 PF00018.23 KII64242.1 - 7e-17 60.5 0.1 1.5e-16 59.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KII64242.1 - 5.5e-15 54.6 0.0 1.3e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KII64242.1 - 9.9e-15 53.7 0.0 2.3e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Pinin_SDK_memA PF04696.8 KII64243.1 - 1.1e-19 70.3 12.4 2e-19 69.4 8.6 1.4 1 0 0 1 1 1 1 pinin/SDK/memA/ protein conserved region Oxysterol_BP PF01237.13 KII64246.1 - 1.9e-111 371.9 0.9 2.3e-111 371.7 0.0 1.6 2 0 0 2 2 2 1 Oxysterol-binding protein PH PF00169.24 KII64246.1 - 1.1e-06 28.7 0.1 3.4e-06 27.1 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 KII64246.1 - 0.00027 20.9 0.4 0.00063 19.7 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.1 KII64246.1 - 0.00051 20.2 4.6 0.00051 20.2 3.2 2.2 2 1 0 2 2 2 1 Pleckstrin homology domain Methyltransf_12 PF08242.7 KII64248.1 - 2.8e-09 37.3 0.0 5.3e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 KII64248.1 - 2.6e-06 26.6 0.0 3.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 KII64248.1 - 1.3e-05 25.7 0.0 1.8e-05 25.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII64248.1 - 4.4e-05 23.8 0.0 7.8e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII64248.1 - 0.00024 20.7 0.5 0.00034 20.2 0.4 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KII64248.1 - 0.0016 18.1 0.0 0.002 17.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 KII64248.1 - 0.0016 17.4 0.0 0.0022 17.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_25 PF13649.1 KII64248.1 - 0.0078 16.5 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KII64248.1 - 0.0081 15.5 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 KII64248.1 - 0.069 13.1 0.0 0.092 12.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DDE_3 PF13358.1 KII64249.1 - 3.8e-27 94.8 0.0 5.1e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII64249.1 - 0.069 12.7 0.0 0.33 10.5 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix HAP2-GCS1 PF10699.4 KII64250.1 - 8.7e-14 51.2 0.0 2.4e-13 49.8 0.0 1.8 1 0 0 1 1 1 1 Male gamete fusion factor Annexin PF00191.15 KII64251.1 - 9.7e-23 79.8 0.3 2.7e-20 72.0 0.0 2.4 2 0 0 2 2 2 2 Annexin Tubulin PF00091.20 KII64252.1 - 1.3e-71 240.8 0.0 2.2e-71 240.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KII64252.1 - 2.7e-42 143.7 0.2 4.3e-42 143.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 KII64252.1 - 3e-06 27.2 0.0 7e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain DDE_Tnp_IS1595 PF12762.2 KII64253.1 - 7.7e-11 42.0 0.1 2.3e-10 40.5 0.0 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain HHH_4 PF14490.1 KII64253.1 - 0.15 11.8 0.0 0.68 9.7 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix containing domain Dak2 PF02734.12 KII64253.1 - 0.16 11.5 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 DAK2 domain DDE_Tnp_IS1595 PF12762.2 KII64254.1 - 5.6e-18 65.2 0.0 6.1e-18 65.1 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain CSD PF00313.17 KII64255.1 - 0.25 11.1 0.8 0.71 9.6 0.2 2.0 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain rve PF00665.21 KII64256.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain G-alpha PF00503.15 KII64258.1 - 2.8e-89 299.5 5.6 3.1e-89 299.3 3.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KII64258.1 - 2.5e-09 36.6 0.0 5.1e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family tRNA-synt_2d PF01409.15 KII64259.1 - 0.011 14.9 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) B3_4 PF03483.12 KII64260.1 - 2.6e-12 46.5 0.0 4.4e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 B3/4 domain Proteasome PF00227.21 KII64260.1 - 1.7e-08 33.9 0.0 0.0013 18.0 0.0 2.3 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.4 KII64260.1 - 5.4e-05 22.4 0.1 0.00014 21.0 0.1 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Brix PF04427.13 KII64261.1 - 2.5e-27 95.8 0.1 3.5e-27 95.2 0.1 1.2 1 0 0 1 1 1 1 Brix domain NDUFA12 PF05071.11 KII64262.1 - 1.1e-20 73.9 0.0 1.5e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 RVP PF00077.15 KII64263.1 - 0.011 15.5 0.0 0.066 13.1 0.0 2.2 1 1 1 2 2 2 0 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII64263.1 - 0.024 15.1 0.1 0.057 13.9 0.0 1.6 1 1 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII64263.1 - 0.1 12.4 0.1 0.19 11.5 0.0 1.6 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease uDENN PF03456.13 KII64264.1 - 0.04 13.8 0.8 0.19 11.6 0.2 1.9 2 0 0 2 2 2 0 uDENN domain Fringe PF02434.11 KII64265.1 - 2.1e-08 33.7 0.5 3.7e-08 32.9 0.2 1.5 2 0 0 2 2 2 1 Fringe-like Galactosyl_T PF01762.16 KII64265.1 - 1.8e-06 27.7 0.2 3.4e-06 26.8 0.2 1.4 1 0 0 1 1 1 1 Galactosyltransferase Ribosomal_S24e PF01282.14 KII64266.1 - 9.7e-30 102.2 0.4 1.6e-29 101.5 0.2 1.5 1 1 0 1 1 1 1 Ribosomal protein S24e Ribosomal_S2 PF00318.15 KII64266.1 - 0.16 11.2 1.7 0.19 10.9 1.2 1.0 1 0 0 1 1 1 0 Ribosomal protein S2 ELO PF01151.13 KII64267.1 - 1.6e-11 44.0 3.1 7.9e-11 41.7 2.2 1.9 1 1 0 1 1 1 1 GNS1/SUR4 family DDE_3 PF13358.1 KII64270.1 - 2.8e-06 27.1 0.0 4.4e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 KII64270.1 - 3.5e-05 23.3 0.0 7.4e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.13 KII64270.1 - 0.00024 20.8 0.0 0.00036 20.2 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.1 KII64270.1 - 0.00034 20.7 0.0 0.00063 19.8 0.0 1.4 1 1 0 1 1 1 1 Winged helix-turn helix MarR_2 PF12802.2 KII64270.1 - 0.002 17.7 0.0 0.0034 17.0 0.0 1.3 1 0 0 1 1 1 1 MarR family CENP-B_N PF04218.8 KII64270.1 - 0.0025 17.2 0.0 0.0053 16.1 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.1 KII64270.1 - 0.0077 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4 PF04545.11 KII64270.1 - 0.016 14.4 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Sigma70_r4_2 PF08281.7 KII64270.1 - 0.022 14.2 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_38 PF13936.1 KII64270.1 - 0.035 13.6 0.0 0.17 11.5 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.1 KII64270.1 - 0.038 13.3 0.0 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TrmB PF01978.14 KII64270.1 - 0.04 13.6 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FliG_N PF14842.1 KII64270.1 - 0.055 13.5 0.1 0.12 12.4 0.0 1.6 2 0 0 2 2 2 0 FliG N-terminal domain Fe_dep_repress PF01325.14 KII64270.1 - 0.059 13.3 0.0 0.097 12.6 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain ComX PF05952.7 KII64270.1 - 0.079 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacillus competence pheromone ComX Phage_CI_repr PF07022.8 KII64270.1 - 0.092 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain Ribosomal_L34 PF00468.12 KII64270.1 - 0.1 12.2 0.2 0.22 11.2 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L34 LMWPc PF01451.16 KII64270.1 - 0.13 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Low molecular weight phosphotyrosine protein phosphatase ATP-grasp_2 PF08442.5 KII64271.1 - 3.9e-67 225.5 0.0 5.7e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 KII64271.1 - 1.4e-15 57.2 0.1 2.3e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.1 KII64271.1 - 1.2e-07 31.1 0.0 2e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 KII64271.1 - 0.014 15.0 0.2 0.032 13.8 0.0 1.7 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RVP PF00077.15 KII64273.1 - 7.3e-08 32.2 0.6 2.6e-07 30.4 0.1 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Retrotrans_gag PF03732.12 KII64273.1 - 5.3e-05 23.1 0.1 0.00014 21.8 0.1 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.18 KII64273.1 - 8.3e-05 22.3 2.7 0.00014 21.5 1.9 1.4 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII64273.1 - 0.0002 21.8 0.1 0.00047 20.6 0.0 1.7 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII64273.1 - 0.00022 20.9 0.0 0.00051 19.8 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII64273.1 - 0.00091 18.7 0.2 0.0023 17.5 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2E PF12382.3 KII64273.1 - 0.0018 18.1 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon peptidase zf-CCHC_4 PF14392.1 KII64273.1 - 0.044 13.4 0.2 0.09 12.4 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.1 KII64273.1 - 0.078 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Zinc knuckle DUF1759 PF03564.10 KII64273.1 - 0.11 12.2 1.1 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) SlyX PF04102.7 KII64273.1 - 0.2 12.0 0.3 0.2 12.0 0.2 2.3 2 0 0 2 2 2 0 SlyX zf-CCHC_5 PF14787.1 KII64273.1 - 0.27 10.7 2.2 0.5 9.8 1.5 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger HR1 PF02185.11 KII64273.1 - 0.54 10.0 7.1 0.055 13.2 0.6 2.3 2 0 0 2 2 2 0 Hr1 repeat TMF_DNA_bd PF12329.3 KII64273.1 - 5.8 6.7 8.3 0.46 10.3 1.4 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Corona_6B_7B PF03262.8 KII64274.1 - 0.041 13.1 0.0 0.05 12.8 0.0 1.1 1 0 0 1 1 1 0 Coronavirus 6B/7B protein Laminin_G_2 PF02210.19 KII64276.1 - 1.7e-47 160.6 1.2 1.8e-13 50.6 0.0 4.6 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.18 KII64276.1 - 2.6e-25 88.9 0.1 3.7e-09 36.6 0.0 5.3 4 1 0 5 5 5 4 Laminin G domain EGF PF00008.22 KII64276.1 - 0.00014 21.7 4.9 0.00014 21.7 3.4 3.2 3 0 0 3 3 3 1 EGF-like domain Polysacc_lyase PF14099.1 KII64276.1 - 0.12 12.0 0.3 47 3.5 0.0 3.3 4 0 0 4 4 4 0 Polysaccharide lyase Thioredoxin PF00085.15 KII64279.1 - 6.3e-15 54.7 0.0 9.7e-15 54.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KII64279.1 - 0.00045 20.3 0.0 0.0024 18.0 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Serpin PF00079.15 KII64280.1 - 5.8e-49 167.1 1.3 6.6e-49 167.0 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Peptidase_C34 PF05413.6 KII64281.1 - 0.09 12.8 0.9 0.12 12.4 0.1 1.6 2 0 0 2 2 2 0 Putative closterovirus papain-like endopeptidase Pox_A32 PF04665.7 KII64282.1 - 0.052 12.8 0.2 0.067 12.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein Baculo_PEP_N PF04512.7 KII64283.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, N terminus Nudix_N_2 PF14803.1 KII64284.1 - 0.096 12.3 1.1 0.17 11.5 0.7 1.4 1 0 0 1 1 1 0 Nudix N-terminal DZR PF12773.2 KII64284.1 - 0.13 12.1 0.4 0.24 11.2 0.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon DDE_1 PF03184.14 KII64286.1 - 1.1e-15 57.4 1.3 1.4e-13 50.5 0.9 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII64286.1 - 0.25 11.1 0.2 0.25 11.1 0.1 2.6 3 0 0 3 3 3 0 Tc5 transposase DNA-binding domain Adeno_E3_14_5 PF04834.7 KII64287.1 - 0.02 15.3 1.9 0.048 14.0 1.3 1.7 1 0 0 1 1 1 0 Early E3 14.5 kDa protein DUF3792 PF12670.2 KII64287.1 - 0.031 14.1 2.5 0.048 13.5 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) Thg1 PF04446.7 KII64287.1 - 0.034 13.7 0.3 0.058 13.0 0.2 1.4 1 0 0 1 1 1 0 tRNAHis guanylyltransferase DUF588 PF04535.7 KII64287.1 - 0.053 13.0 1.4 0.075 12.5 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF588) Use1 PF09753.4 KII64287.1 - 0.1 12.0 1.6 0.16 11.4 1.1 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF3753 PF12575.3 KII64287.1 - 0.74 9.6 6.8 0.18 11.5 2.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3753) Staphopain_pro PF14731.1 KII64287.1 - 1.4 8.6 8.5 0.36 10.5 2.5 2.0 1 1 1 2 2 2 0 Staphopain proregion CCSMST1 PF15013.1 KII64288.1 - 0.025 14.5 0.1 0.049 13.5 0.1 1.4 1 0 0 1 1 1 0 CCSMST1 family DUF1091 PF06477.8 KII64288.1 - 0.082 13.3 2.9 0.74 10.2 0.5 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1091) DUF3149 PF11346.3 KII64288.1 - 0.31 10.6 4.6 0.57 9.7 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) DUF912 PF06024.7 KII64290.1 - 0.0079 16.2 0.8 0.012 15.6 0.6 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Phospholamban PF04272.9 KII64290.1 - 0.13 11.7 0.9 0.29 10.5 0.2 1.9 1 1 0 1 1 1 0 Phospholamban DUF3671 PF12420.3 KII64290.1 - 0.14 12.1 4.2 0.22 11.5 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF4097 PF13349.1 KII64291.1 - 0.08 12.4 2.0 0.31 10.5 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4097) Ctr PF04145.10 KII64291.1 - 0.16 12.0 0.1 0.16 12.0 0.0 1.8 2 0 0 2 2 2 0 Ctr copper transporter family HTH_Tnp_Tc3_2 PF01498.13 KII64293.1 - 0.0056 16.7 0.2 0.011 15.7 0.1 1.5 1 1 0 1 1 1 1 Transposase Arg_repressor PF01316.16 KII64293.1 - 0.008 15.7 1.2 0.0096 15.4 0.1 1.7 2 0 0 2 2 2 1 Arginine repressor, DNA binding domain DUF1003 PF06210.6 KII64294.1 - 0.026 14.4 0.1 0.047 13.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) NDUFB10 PF10249.4 KII64294.1 - 0.03 14.4 1.9 0.03 14.4 1.3 1.7 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 DUF3931 PF13082.1 KII64295.1 - 0.062 13.1 3.0 7.6 6.4 0.2 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3931) DUF4325 PF14213.1 KII64297.1 - 0.15 11.7 0.0 0.49 10.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4325) Ion_trans PF00520.26 KII64298.1 - 6.3e-07 28.8 2.3 8.7e-07 28.3 0.3 2.0 2 0 0 2 2 2 1 Ion transport protein TACI-CRD2 PF09305.5 KII64298.1 - 0.027 14.2 1.2 0.027 14.2 0.8 1.8 2 0 0 2 2 2 0 TACI, cysteine-rich domain NOG1 PF06858.9 KII64301.1 - 1.2e-25 89.1 0.2 2.6e-25 88.0 0.1 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.18 KII64301.1 - 1.2e-17 63.9 0.0 4.3e-17 62.1 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase NOGCT PF08155.6 KII64301.1 - 5.8e-15 54.7 1.9 1.7e-14 53.1 1.3 1.9 1 0 0 1 1 1 1 NOGCT (NUC087) domain FeoB_N PF02421.13 KII64301.1 - 1e-10 41.1 0.0 2.2e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 KII64301.1 - 0.0065 16.9 0.0 0.022 15.2 0.0 2.0 1 0 0 1 1 1 1 Miro-like protein AIG1 PF04548.11 KII64301.1 - 0.016 14.2 0.1 0.053 12.6 0.0 2.0 2 0 0 2 2 2 0 AIG1 family Dynamin_N PF00350.18 KII64301.1 - 0.016 14.9 0.2 2.1 8.1 0.0 2.8 1 1 1 2 2 2 0 Dynamin family DUF258 PF03193.11 KII64301.1 - 0.07 12.3 0.0 0.29 10.3 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 KII64301.1 - 0.086 13.6 0.3 0.87 10.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain SNAP PF14938.1 KII64303.1 - 9.5e-05 21.6 0.0 0.00014 21.1 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF1942 PF09167.6 KII64303.1 - 0.045 13.5 0.0 0.17 11.6 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1942) SNAP PF14938.1 KII64304.1 - 4.3e-08 32.6 1.8 6.1e-08 32.1 1.3 1.4 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP zf-met PF12874.2 KII64306.1 - 1.1 9.5 8.8 6 7.2 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KII64306.1 - 1.8 8.8 8.6 1.6 8.9 0.2 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding RVT_1 PF00078.22 KII64307.1 - 3e-05 23.4 0.1 0.0001 21.7 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Corona_S2 PF01601.11 KII64310.1 - 0.011 13.8 3.0 0.016 13.3 2.1 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein IncA PF04156.9 KII64310.1 - 0.13 11.8 3.0 0.32 10.5 1.8 1.5 1 1 0 1 1 1 0 IncA protein Laminin_II PF06009.7 KII64310.1 - 0.15 11.7 4.0 0.82 9.4 0.7 2.3 2 1 0 2 2 2 0 Laminin Domain II NPV_P10 PF05531.7 KII64310.1 - 0.45 10.7 3.7 0.58 10.4 0.7 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.7 KII64310.1 - 0.67 10.3 3.8 5.5 7.4 0.2 2.5 2 0 0 2 2 2 0 SlyX DUF1664 PF07889.7 KII64310.1 - 4 7.2 6.4 1.2 8.9 1.2 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) RVT_1 PF00078.22 KII64311.1 - 4e-29 101.5 0.1 3.9e-28 98.2 0.0 2.6 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII64311.1 - 3.9e-09 36.3 0.0 1.4e-08 34.5 0.0 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII64311.1 - 0.00013 22.3 0.0 0.00029 21.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2B PF12384.3 KII64311.1 - 0.0084 15.4 0.0 0.02 14.2 0.0 1.6 1 0 0 1 1 1 1 Ty3 transposon peptidase Peptidase_A2E PF12382.3 KII64311.1 - 0.0085 15.9 0.1 0.033 14.0 0.1 2.0 1 0 0 1 1 1 1 Retrotransposon peptidase GSH_synth_ATP PF03917.12 KII64311.1 - 0.042 12.4 0.0 0.064 11.8 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain Asp_protease PF09668.5 KII64311.1 - 0.071 12.6 0.2 0.33 10.5 0.1 2.0 1 1 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII64311.1 - 0.17 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII64311.1 - 0.19 11.3 5.1 3.5 7.3 0.3 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.1 KII64311.1 - 0.72 9.3 14.0 0.19 11.2 1.9 2.7 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.18 KII64311.1 - 4.2 7.4 7.5 0.18 11.7 0.4 2.4 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.1 KII64312.1 - 4.7e-11 42.6 0.3 1e-09 38.3 0.2 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease PAP2_C PF14360.1 KII64313.1 - 7.3e-17 61.4 17.4 7.3e-17 61.4 12.1 2.6 2 1 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.16 KII64313.1 - 0.001 18.7 15.7 0.0023 17.6 10.8 1.7 1 1 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.1 KII64313.1 - 0.0031 17.0 17.3 0.009 15.5 12.0 1.7 1 1 0 1 1 1 1 PAP2 superfamily CDC50 PF03381.10 KII64314.1 - 1.7e-08 33.9 2.8 4.1e-08 32.7 1.9 1.6 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family IP_trans PF02121.13 KII64315.1 - 3.2e-70 236.2 0.0 3.8e-70 235.9 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Det1 PF09737.4 KII64315.1 - 0.013 14.3 0.0 0.019 13.7 0.0 1.1 1 0 0 1 1 1 0 De-etiolated protein 1 Det1 RIB43A PF05914.7 KII64315.1 - 0.12 11.0 0.1 0.17 10.4 0.1 1.1 1 0 0 1 1 1 0 RIB43A Smg4_UPF3 PF03467.10 KII64317.1 - 6.6e-08 32.7 0.8 9e-08 32.3 0.3 1.5 1 1 0 1 1 1 1 Smg-4/UPF3 family RRM_1 PF00076.17 KII64317.1 - 0.03 13.9 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII64317.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PHD PF00628.24 KII64318.1 - 9.5e-17 60.4 21.8 2.6e-11 43.0 3.3 2.5 2 0 0 2 2 2 2 PHD-finger PHD_2 PF13831.1 KII64318.1 - 0.00033 19.8 20.6 0.00079 18.6 0.6 3.4 3 1 1 4 4 4 2 PHD-finger NPDC1 PF06809.6 KII64318.1 - 0.0033 16.2 2.6 0.0033 16.2 1.8 1.3 1 1 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) Prok-RING_1 PF14446.1 KII64318.1 - 0.02 14.6 1.2 0.02 14.6 0.8 3.5 4 1 0 4 4 4 0 Prokaryotic RING finger family 1 zf-RanBP PF00641.13 KII64318.1 - 0.03 13.4 0.2 0.03 13.4 0.2 3.9 4 0 0 4 4 4 0 Zn-finger in Ran binding protein and others C1_1 PF00130.17 KII64318.1 - 0.21 11.3 0.3 0.21 11.3 0.2 3.6 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SNF2_N PF00176.18 KII64319.1 - 1.4e-60 204.6 0.1 2.3e-60 203.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KII64319.1 - 9e-17 60.7 0.0 2e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.19 KII64319.1 - 6.7e-09 35.2 0.3 2e-08 33.7 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.10 KII64319.1 - 2.3e-07 30.8 0.0 5e-06 26.4 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KII64319.1 - 0.003 17.6 0.2 0.03 14.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain DEAD PF00270.24 KII64319.1 - 0.01 15.3 0.0 0.47 9.9 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase Helicase_C_4 PF13871.1 KII64319.1 - 0.03 13.7 0.2 0.26 10.6 0.0 2.2 1 1 1 2 2 2 0 Helicase_C-like CHDCT2 PF08074.6 KII64320.1 - 1.1e-20 74.0 0.1 1.9e-20 73.3 0.1 1.3 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1087 PF06465.8 KII64320.1 - 2.7e-10 40.0 1.3 6e-10 38.8 0.9 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1087) SnAC PF14619.1 KII64320.1 - 0.0084 16.2 0.5 0.025 14.7 0.3 1.8 1 0 0 1 1 1 1 Snf2-ATP coupling, chromatin remodelling complex Ded_cyto PF06920.8 KII64321.1 - 7.1e-09 35.2 0.0 1.4e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 Dedicator of cytokinesis Longin PF13774.1 KII64325.1 - 0.082 12.4 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Regulated-SNARE-like domain Ldl_recept_a PF00057.13 KII64326.1 - 2e-07 30.7 14.3 2.9e-07 30.2 9.2 1.9 1 1 0 1 1 1 1 Low-density lipoprotein receptor domain class A Chondroitinas_B PF14592.1 KII64326.1 - 0.051 12.4 0.0 0.077 11.8 0.0 1.2 1 0 0 1 1 1 0 Chondroitinase B E1_DerP2_DerF2 PF02221.10 KII64329.1 - 2.1e-07 31.2 0.0 2.6e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 ML domain Ldl_recept_a PF00057.13 KII64331.1 - 1.4e-35 120.9 105.8 7.5e-11 41.7 6.3 6.9 5 2 2 7 7 7 6 Low-density lipoprotein receptor domain class A UXS1_N PF11803.3 KII64331.1 - 0.091 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal HTH_Tnp_IS630 PF01710.11 KII64332.1 - 8.4e-07 28.6 0.1 9.9e-07 28.4 0.1 1.1 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.1 KII64332.1 - 1.1e-06 28.5 0.0 4e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 KII64332.1 - 1.8e-06 27.3 0.0 2.9e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.1 KII64332.1 - 4.9e-05 24.0 0.0 0.00012 22.7 0.1 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII64332.1 - 0.0002 21.4 0.0 0.00034 20.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 KII64332.1 - 0.00033 20.3 0.0 0.00042 20.0 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_24 PF13412.1 KII64332.1 - 0.0014 18.0 0.0 0.023 14.0 0.0 2.4 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.1 KII64332.1 - 0.0041 16.8 0.1 0.15 11.8 0.0 2.2 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII64332.1 - 0.008 16.2 1.4 0.021 14.8 0.5 1.9 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.1 KII64332.1 - 0.032 13.7 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Arg_repressor PF01316.16 KII64332.1 - 0.1 12.1 0.4 0.18 11.3 0.3 1.5 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Topo_C_assoc PF14370.1 KII64333.1 - 0.083 12.5 0.1 13 5.5 0.0 2.4 1 1 1 2 2 2 0 C-terminal topoisomerase domain Baculo_VP91_N PF08475.5 KII64333.1 - 0.3 10.4 3.2 0.32 10.3 1.5 1.6 1 1 0 1 1 1 0 Viral capsid protein 91 N-terminal EcoRI_methylase PF13651.1 KII64335.1 - 0.039 13.0 0.0 0.051 12.6 0.0 1.2 1 0 0 1 1 1 0 Adenine-specific methyltransferase EcoRI FLYWCH PF04500.11 KII64336.1 - 6e-09 35.6 1.0 9.9e-09 34.9 0.7 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain DUF2678 PF10856.3 KII64337.1 - 2.6 7.8 5.1 5.3 6.8 0.0 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF2678) FLYWCH PF04500.11 KII64338.1 - 0.12 12.3 2.8 0.2 11.5 2.0 1.3 1 0 0 1 1 1 0 FLYWCH zinc finger domain DDE_Tnp_IS1595 PF12762.2 KII64339.1 - 1.3e-08 34.8 0.6 2.1e-08 34.1 0.4 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Spuma_A9PTase PF03539.9 KII64339.1 - 0.0039 17.1 0.2 0.011 15.7 0.0 1.8 2 0 0 2 2 2 1 Spumavirus aspartic protease (A9) PDGF_N PF04692.8 KII64339.1 - 0.074 13.5 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region Ldl_recept_a PF00057.13 KII64342.1 - 7.2e-08 32.2 9.8 7.2e-08 32.2 6.8 3.2 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A DDE_3 PF13358.1 KII64348.1 - 2.7e-12 46.6 0.0 3.7e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-CCHC PF00098.18 KII64353.1 - 2.7e-06 27.0 2.5 5.6e-06 26.0 1.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-FCS PF06467.9 KII64353.1 - 0.033 13.8 0.4 0.033 13.8 0.3 1.9 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif PyrI_C PF02748.10 KII64353.1 - 0.038 13.4 1.0 0.069 12.5 0.2 1.8 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain YqgF PF14639.1 KII64353.1 - 0.08 12.4 0.0 0.2 11.2 0.0 1.6 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 zf-CCHC_6 PF15288.1 KII64353.1 - 0.12 12.0 1.6 0.23 11.1 1.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII64353.1 - 0.34 10.6 2.3 0.71 9.5 1.6 1.5 1 0 0 1 1 1 0 Zinc knuckle NAP PF00956.13 KII64354.1 - 2.2e-47 161.2 4.9 2.8e-47 160.8 3.4 1.1 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) RasGEF PF00617.14 KII64355.1 - 1.5e-27 96.5 0.2 1.9e-27 96.2 0.1 1.2 1 0 0 1 1 1 1 RasGEF domain RVT_1 PF00078.22 KII64356.1 - 0.00062 19.1 0.0 0.002 17.5 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSP20 PF00011.16 KII64358.1 - 2.9e-19 68.7 1.4 7.7e-09 35.3 0.0 2.2 2 0 0 2 2 2 2 Hsp20/alpha crystallin family YabP PF07873.6 KII64358.1 - 4.2e-05 23.0 0.0 0.00013 21.4 0.0 1.9 1 0 0 1 1 1 1 YabP family CS PF04969.11 KII64358.1 - 0.72 10.4 5.6 9.8 6.8 0.2 3.6 2 2 1 3 3 3 0 CS domain DDE_Tnp_IS1595 PF12762.2 KII64360.1 - 0.0001 22.1 0.1 0.00017 21.4 0.1 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain DnaJ PF00226.26 KII64361.1 - 3.9e-23 80.9 1.2 3.9e-23 80.9 0.8 1.8 2 0 0 2 2 2 1 DnaJ domain DUF1977 PF09320.6 KII64361.1 - 1.8e-22 79.6 0.4 1.8e-22 79.6 0.3 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) PC_rep PF01851.17 KII64362.1 - 4.8e-18 64.3 3.6 0.0068 16.5 0.0 7.4 6 0 0 6 6 6 4 Proteasome/cyclosome repeat HEAT_2 PF13646.1 KII64362.1 - 5.8e-05 23.3 0.3 0.089 13.0 0.0 3.2 3 0 0 3 3 3 2 HEAT repeats LRAT PF04970.8 KII64362.1 - 0.059 13.3 0.1 0.22 11.4 0.0 2.0 1 0 0 1 1 1 0 Lecithin retinol acyltransferase OSCP PF00213.13 KII64363.1 - 0.16 11.7 0.9 3.8 7.3 0.1 2.1 1 1 1 2 2 2 0 ATP synthase delta (OSCP) subunit DUF2396 PF09654.5 KII64364.1 - 0.092 12.7 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2396) Evr1_Alr PF04777.8 KII64364.1 - 0.11 12.3 2.4 3.6 7.5 0.2 2.4 2 1 0 2 2 2 0 Erv1 / Alr family zf-FCS PF06467.9 KII64364.1 - 0.22 11.1 2.0 15 5.3 0.0 3.0 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif C1_1 PF00130.17 KII64364.1 - 0.27 11.0 0.2 0.27 11.0 0.1 2.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HTH_36 PF13730.1 KII64365.1 - 0.0058 16.7 0.1 0.16 12.1 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain Fe_dep_repress PF01325.14 KII64365.1 - 0.089 12.7 0.1 0.4 10.6 0.0 2.1 3 0 0 3 3 3 0 Iron dependent repressor, N-terminal DNA binding domain PLDc_2 PF13091.1 KII64366.1 - 8.4e-19 67.5 0.2 1.2e-18 67.0 0.2 1.2 1 0 0 1 1 1 1 PLD-like domain DUF1173 PF06666.6 KII64366.1 - 4.5e-08 32.3 0.1 6.2e-08 31.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1173) DUF1669 PF07894.7 KII64366.1 - 9.9e-05 21.6 0.0 0.011 15.0 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1669) DUF790 PF05626.6 KII64366.1 - 0.019 13.5 0.0 0.035 12.6 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF790) Acetyltransf_1 PF00583.19 KII64368.1 - 1.1e-12 47.7 0.0 1.6e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KII64368.1 - 1.5e-08 34.7 0.0 1.7e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KII64368.1 - 2.2e-06 27.7 0.0 4.5e-06 26.7 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KII64368.1 - 6.5e-06 25.8 0.0 2.1e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.1 KII64368.1 - 0.0015 18.3 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.1 KII64368.1 - 0.0047 16.7 0.0 0.0063 16.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF619 PF04768.8 KII64368.1 - 0.071 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF619) tRNA-synt_1g PF09334.6 KII64369.1 - 1.3e-08 33.9 0.1 1.7e-08 33.5 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 KII64369.1 - 1.3e-06 26.7 0.1 1.8e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) CCSMST1 PF15013.1 KII64369.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 CCSMST1 family K_oxygenase PF13434.1 KII64370.1 - 3.1e-90 302.5 0.3 3.6e-90 302.3 0.2 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.1 KII64370.1 - 6.7e-12 45.8 0.0 2.3e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KII64370.1 - 1.5e-06 28.0 0.0 5.2e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding NIPSNAP PF07978.8 KII64371.1 - 8.2e-09 35.3 0.0 8.8e-09 35.2 0.0 1.0 1 0 0 1 1 1 1 NIPSNAP HEPN PF05168.9 KII64372.1 - 0.00085 19.1 0.1 0.0018 18.1 0.1 1.6 1 1 0 1 1 1 1 HEPN domain Ycf54 PF10674.4 KII64372.1 - 0.1 12.7 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) Toxin_17 PF08086.6 KII64372.1 - 5.5 7.1 8.6 0.71 9.9 0.6 2.8 2 1 0 2 2 2 0 Ergtoxin family SMC_N PF02463.14 KII64374.1 - 5.5e-09 35.5 0.0 6.5e-08 32.0 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KII64374.1 - 3.1e-08 34.1 0.2 1e-07 32.4 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KII64374.1 - 1.4e-05 25.2 0.6 0.12 12.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain PHP_C PF13263.1 KII64374.1 - 0.00027 20.3 0.0 0.00071 19.0 0.0 1.7 1 0 0 1 1 1 1 PHP-associated AAA_29 PF13555.1 KII64374.1 - 0.0031 17.0 0.0 0.0089 15.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 KII64374.1 - 0.0072 16.6 0.0 0.028 14.7 0.0 2.0 2 0 0 2 2 2 1 ABC transporter MobB PF03205.9 KII64374.1 - 0.064 12.9 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF3800 PF12686.2 KII64375.1 - 9.6e-09 35.2 0.0 0.0029 17.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3800) DUSP PF06337.7 KII64376.1 - 0.077 13.4 1.5 0.096 13.0 1.0 1.3 1 0 0 1 1 1 0 DUSP domain EnY2 PF10163.4 KII64376.1 - 0.081 12.8 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Transcription factor e(y)2 MarR_2 PF12802.2 KII64377.1 - 0.00035 20.1 0.0 0.0009 18.8 0.0 1.7 1 0 0 1 1 1 1 MarR family DUF1814 PF08843.6 KII64378.1 - 6.8e-08 32.5 0.0 1.3e-07 31.6 0.0 1.3 1 1 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF1814) FTO_NTD PF12933.2 KII64378.1 - 0.08 12.0 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 FTO catalytic domain Phage_integrase PF00589.17 KII64380.1 - 5.3e-33 114.1 0.0 9.3e-33 113.3 0.0 1.4 1 1 0 1 1 1 1 Phage integrase family DUF1817 PF08847.6 KII64380.1 - 0.046 13.2 0.0 0.063 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1817) HTH_19 PF12844.2 KII64381.1 - 0.0026 17.7 0.2 0.01 15.8 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain DUF771 PF05595.6 KII64381.1 - 0.068 13.0 2.5 0.1 12.5 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF771) BNR PF02012.15 KII64382.1 - 8.8e-07 27.8 0.5 0.64 10.0 0.0 3.7 3 0 0 3 3 3 3 BNR/Asp-box repeat Peptidase_C57 PF03290.8 KII64383.1 - 0.024 13.1 0.0 0.028 12.9 0.0 1.0 1 0 0 1 1 1 0 Vaccinia virus I7 processing peptidase BNR PF02012.15 KII64384.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.4 4 0 0 4 4 4 0 BNR/Asp-box repeat BNR PF02012.15 KII64385.1 - 0.0044 16.6 3.5 0.2 11.6 0.1 3.9 4 0 0 4 4 4 2 BNR/Asp-box repeat BNR PF02012.15 KII64387.1 - 0.0024 17.4 4.7 2.5 8.2 0.0 4.3 4 0 0 4 4 4 3 BNR/Asp-box repeat Paf1 PF03985.8 KII64388.1 - 0.0024 16.7 1.0 0.0025 16.6 0.7 1.1 1 0 0 1 1 1 1 Paf1 rve PF00665.21 KII64390.1 - 4.4e-23 81.6 0.1 8.5e-23 80.7 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain DNA_ligase_A_C PF04679.10 KII64392.1 - 1.1e-08 35.3 0.1 1.6e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region 7tm_1 PF00001.16 KII64393.1 - 2.6e-13 49.6 22.8 6.9e-13 48.3 15.8 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-C2H2 PF00096.21 KII64395.1 - 0.0061 16.8 3.5 0.012 15.9 2.4 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.2 KII64395.1 - 0.0096 16.0 2.2 0.022 14.9 1.5 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 KII64395.1 - 0.011 15.8 0.2 0.027 14.5 0.2 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 KII64395.1 - 0.017 15.2 3.0 0.032 14.3 2.1 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF848 PF05852.6 KII64395.1 - 0.019 14.8 5.7 0.021 14.7 2.0 2.3 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) DUF4300 PF14133.1 KII64395.1 - 0.55 9.4 8.4 3.1 7.0 5.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4300) GrpE PF01025.14 KII64395.1 - 2.4 7.6 5.8 0.19 11.2 0.7 1.5 2 0 0 2 2 2 0 GrpE DUF1108 PF06531.6 KII64397.1 - 0.0023 18.0 1.4 0.004 17.2 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1108) CDC45 PF02724.9 KII64397.1 - 0.55 8.1 5.3 0.58 8.1 3.7 1.0 1 0 0 1 1 1 0 CDC45-like protein BRO1 PF03097.13 KII64398.1 - 0.034 12.9 0.2 0.27 9.9 0.0 1.9 1 1 1 2 2 2 0 BRO1-like domain DUF4509 PF14970.1 KII64398.1 - 0.1 12.2 0.6 0.11 12.1 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4509) Abhydrolase_3 PF07859.8 KII64399.1 - 9.4e-43 146.2 0.0 6.1e-29 101.0 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold HSL_N PF06350.7 KII64399.1 - 3.3e-09 36.2 0.3 4.7e-09 35.7 0.2 1.2 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus DUF2424 PF10340.4 KII64399.1 - 9e-09 34.4 0.0 1.4e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) DLH PF01738.13 KII64399.1 - 0.049 12.9 0.0 0.14 11.3 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 KII64399.1 - 0.051 13.3 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF997 PF06196.7 KII64401.1 - 0.027 13.9 0.6 0.027 13.9 0.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF997) 7TM-7TMR_HD PF07698.6 KII64401.1 - 0.045 13.1 7.3 0.058 12.8 5.1 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF553 PF04473.7 KII64401.1 - 0.057 12.6 1.8 0.076 12.2 1.2 1.3 1 0 0 1 1 1 0 Transglutaminase-like domain zf-DHHC PF01529.15 KII64402.1 - 1.9e-14 53.4 8.6 2.3e-14 53.1 6.0 1.3 1 1 0 1 1 1 1 DHHC palmitoyltransferase E2F_TDP PF02319.15 KII64404.1 - 8.5e-24 82.9 0.0 1.5e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain B-block_TFIIIC PF04182.7 KII64404.1 - 0.099 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC WD40_alt PF14077.1 KII64404.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif Usp PF00582.21 KII64405.1 - 1.4e-07 31.7 0.0 4.1e-07 30.2 0.0 1.7 1 1 0 1 1 1 1 Universal stress protein family DUF2338 PF10100.4 KII64405.1 - 0.019 13.3 0.1 0.022 13.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2338) Lipl32 PF12103.3 KII64407.1 - 2.9 7.3 15.9 0.044 13.2 2.5 2.5 1 1 0 2 2 2 0 Surface lipoprotein of Spirochaetales order Carb_anhydrase PF00194.16 KII64408.1 - 9.4e-20 70.6 0.0 1.1e-19 70.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.16 KII64409.1 - 2.7e-16 59.3 0.0 3.4e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Kelch_4 PF13418.1 KII64410.1 - 0.016 14.9 0.1 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Galactose oxidase, central domain PWWP PF00855.12 KII64417.1 - 0.068 13.3 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 PWWP domain zf-UBR PF02207.15 KII64419.1 - 1.4e-06 27.9 2.7 1.4e-06 27.9 1.9 2.5 2 0 0 2 2 2 2 Putative zinc finger in N-recognin (UBR box) ATP_bind_1 PF03029.12 KII64419.1 - 0.048 13.1 0.1 1.2 8.6 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein CATSPERB PF15149.1 KII64421.1 - 0.042 12.0 0.0 0.042 12.0 0.0 1.1 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit beta protein family Ly49 PF08391.5 KII64421.1 - 0.13 12.3 1.3 0.48 10.5 0.0 2.0 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Ras PF00071.17 KII64422.1 - 2.6e-36 124.4 0.3 3.3e-36 124.1 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII64422.1 - 1.7e-17 64.0 0.0 2.7e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII64422.1 - 3e-13 49.3 0.2 6.9e-13 48.2 0.1 1.6 1 1 1 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KII64422.1 - 1.2e-06 28.1 1.0 4.2e-06 26.3 0.7 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KII64422.1 - 1.8e-05 24.6 0.1 3.5e-05 23.7 0.0 1.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.5 KII64422.1 - 0.00011 21.5 0.1 0.00014 21.1 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Viral_helicase1 PF01443.13 KII64422.1 - 0.0014 18.1 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase FeoB_N PF02421.13 KII64422.1 - 0.013 14.7 0.0 1.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_28 PF13521.1 KII64422.1 - 0.028 14.3 0.0 0.051 13.5 0.0 1.5 2 0 0 2 2 1 0 AAA domain Lsr2 PF11774.3 KII64422.1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Lsr2 ArgK PF03308.11 KII64422.1 - 0.031 13.0 0.0 5 5.8 0.0 2.1 2 0 0 2 2 2 0 ArgK protein Arch_ATPase PF01637.13 KII64422.1 - 0.035 13.7 0.2 0.044 13.4 0.1 1.5 1 1 0 1 1 1 0 Archaeal ATPase AAA_33 PF13671.1 KII64422.1 - 0.04 13.7 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KII64422.1 - 0.045 13.9 0.1 0.13 12.3 0.0 1.9 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.17 KII64422.1 - 0.046 12.5 0.3 0.45 9.3 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.1 KII64422.1 - 0.063 12.8 0.7 0.12 11.8 0.5 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KII64422.1 - 0.067 13.1 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 KII64422.1 - 0.068 12.3 0.2 0.13 11.4 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF258 CbiA PF01656.18 KII64422.1 - 0.074 12.4 0.5 2.1 7.7 0.4 2.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_14 PF13173.1 KII64422.1 - 0.096 12.5 0.1 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 KII64422.1 - 0.13 11.7 0.8 0.2 11.1 0.1 1.8 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 KII64422.1 - 0.14 11.8 0.2 0.3 10.7 0.1 1.6 1 1 0 1 1 1 0 NACHT domain SRP54 PF00448.17 KII64422.1 - 0.76 9.1 2.9 1.6 8.0 0.8 2.5 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain DDE_3 PF13358.1 KII64423.1 - 0.0011 18.7 0.2 0.067 12.9 0.0 2.5 2 1 0 2 2 2 1 DDE superfamily endonuclease Sec10 PF07393.6 KII64425.1 - 0.0016 16.7 2.1 0.0017 16.6 1.4 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 CCDC144C PF14915.1 KII64425.1 - 0.0056 15.6 12.6 0.012 14.5 8.7 1.6 1 1 0 1 1 1 1 CCDC144C protein coiled-coil region DUF4259 PF14078.1 KII64425.1 - 0.0079 16.6 0.8 0.0099 16.3 0.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4259) DUF948 PF06103.6 KII64425.1 - 0.0088 15.8 4.1 0.07 12.9 0.9 2.1 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) DUF1313 PF07011.6 KII64425.1 - 0.012 15.2 5.1 0.12 12.0 0.3 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1313) phiKZ_IP PF12699.2 KII64425.1 - 0.013 14.4 3.2 0.014 14.3 2.2 1.1 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins bZIP_1 PF00170.16 KII64425.1 - 0.014 15.3 3.9 0.014 15.3 2.7 2.7 2 1 1 3 3 3 0 bZIP transcription factor Cep57_MT_bd PF06657.8 KII64425.1 - 0.016 15.1 1.0 0.016 15.1 0.7 2.1 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 GAS PF13851.1 KII64425.1 - 0.019 14.1 14.7 0.18 10.9 10.2 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding MCM_N PF14551.1 KII64425.1 - 0.031 14.7 2.0 0.031 14.7 1.4 1.7 1 1 0 2 2 1 0 MCM N-terminal domain Med22 PF06179.7 KII64425.1 - 0.047 13.7 4.4 0.066 13.2 2.8 1.4 1 1 0 1 1 1 0 Surfeit locus protein 5 subunit 22 of Mediator complex Peptidase_M9_N PF08453.5 KII64425.1 - 0.058 12.7 0.4 0.13 11.5 0.2 1.6 1 1 0 1 1 1 0 Peptidase family M9 N-terminal SseC PF04888.7 KII64425.1 - 0.064 12.5 1.8 0.075 12.3 1.2 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF1351 PF07083.6 KII64425.1 - 0.065 12.8 7.1 0.089 12.4 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) LPP PF04728.8 KII64425.1 - 0.073 12.8 0.0 0.69 9.7 0.0 2.1 2 0 0 2 2 2 0 Lipoprotein leucine-zipper PhaP_Bmeg PF09602.5 KII64425.1 - 0.078 12.8 3.9 0.058 13.2 1.6 1.5 1 1 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) PMI_typeI PF01238.16 KII64425.1 - 0.089 11.7 2.6 0.1 11.5 1.8 1.0 1 0 0 1 1 1 0 Phosphomannose isomerase type I Snapin_Pallidin PF14712.1 KII64425.1 - 0.094 13.0 8.3 0.19 12.0 0.5 2.3 2 0 0 2 2 2 0 Snapin/Pallidin DUF148 PF02520.12 KII64425.1 - 0.11 12.2 5.5 0.079 12.7 1.3 2.3 1 1 0 2 2 2 0 Domain of unknown function DUF148 DUF4085 PF13315.1 KII64425.1 - 0.11 11.7 5.6 0.15 11.3 3.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4085) Ribonuc_2-5A PF06479.7 KII64425.1 - 0.12 12.1 2.2 1.4 8.7 0.6 2.1 1 1 1 2 2 2 0 Ribonuclease 2-5A Ribonucleas_3_2 PF11469.3 KII64425.1 - 0.12 12.5 1.6 7.4 6.8 0.0 2.1 1 1 1 2 2 2 0 Ribonuclease III ISG65-75 PF11727.3 KII64425.1 - 0.13 11.2 3.2 0.16 10.9 2.2 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein YlqD PF11068.3 KII64425.1 - 0.14 12.2 8.1 0.34 10.9 5.6 1.8 1 1 0 1 1 1 0 YlqD protein BRE1 PF08647.6 KII64425.1 - 0.14 12.0 9.5 0.69 9.9 0.0 2.7 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase P4Ha_N PF08336.6 KII64425.1 - 0.15 11.9 6.8 1.6 8.5 2.0 2.2 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Med30 PF11315.3 KII64425.1 - 0.15 12.1 8.4 0.19 11.8 5.8 1.0 1 0 0 1 1 1 0 Mediator complex subunit 30 AAA_11 PF13086.1 KII64425.1 - 0.16 11.4 4.2 0.19 11.2 2.9 1.1 1 0 0 1 1 1 0 AAA domain Baculo_PEP_C PF04513.7 KII64425.1 - 0.16 11.7 4.4 0.26 11.1 1.5 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.14 KII64425.1 - 0.21 9.3 6.2 0.24 9.2 4.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.5 KII64425.1 - 0.22 11.6 8.5 0.34 11.0 5.8 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF349 PF03993.7 KII64425.1 - 0.24 11.6 8.7 0.053 13.6 3.3 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) KLRAQ PF10205.4 KII64425.1 - 0.27 11.2 10.4 0.19 11.7 2.6 2.0 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein BING4CT PF08149.6 KII64425.1 - 0.28 10.7 2.8 4.5 6.8 0.0 2.7 2 1 1 3 3 3 0 BING4CT (NUC141) domain DUF4446 PF14584.1 KII64425.1 - 0.3 10.8 7.8 0.08 12.7 1.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) MSC PF09402.5 KII64425.1 - 0.31 9.7 3.7 0.36 9.5 2.6 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain HALZ PF02183.13 KII64425.1 - 0.32 10.7 4.8 0.18 11.5 1.3 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF445 PF04286.7 KII64425.1 - 0.34 10.3 6.2 0.38 10.2 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) AAA_32 PF13654.1 KII64425.1 - 0.39 9.3 7.3 0.44 9.1 5.1 1.1 1 0 0 1 1 1 0 AAA domain RNA_pol_Rpb2_1 PF04563.10 KII64425.1 - 0.39 9.5 2.5 0.57 9.0 1.8 1.4 1 1 0 1 1 1 0 RNA polymerase beta subunit DUF1664 PF07889.7 KII64425.1 - 0.42 10.4 4.9 4.2 7.1 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DivIVA PF05103.8 KII64425.1 - 0.49 10.4 10.8 0.58 10.2 3.9 2.2 1 1 1 2 2 2 0 DivIVA protein Med11 PF10280.4 KII64425.1 - 0.5 10.4 5.3 1 9.4 3.0 2.0 1 1 0 1 1 1 0 Mediator complex protein TMF_TATA_bd PF12325.3 KII64425.1 - 0.62 9.7 9.7 0.18 11.5 1.9 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Occludin_ELL PF07303.8 KII64425.1 - 0.64 10.7 7.6 1.3 9.7 2.5 2.2 1 1 1 2 2 2 0 Occludin homology domain DUF4618 PF15397.1 KII64425.1 - 0.72 9.1 10.3 0.56 9.4 1.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) UPF0449 PF15136.1 KII64425.1 - 0.9 9.7 5.2 0.44 10.7 2.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 Nnf1 PF03980.9 KII64425.1 - 1.1 9.2 8.4 0.11 12.5 2.0 2.0 2 0 0 2 2 2 0 Nnf1 DUF342 PF03961.8 KII64425.1 - 1.2 7.4 10.4 1.5 7.1 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Latarcin PF10279.4 KII64425.1 - 1.3 9.2 7.8 3.6 7.8 1.3 2.5 1 1 1 2 2 2 0 Latarcin precursor CorA PF01544.13 KII64425.1 - 1.3 7.9 5.7 1.2 8.1 1.7 1.7 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein ADIP PF11559.3 KII64425.1 - 1.6 8.5 13.7 7 6.5 2.6 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ArsC PF03960.10 KII64425.1 - 1.8 8.6 6.4 0.93 9.5 2.0 2.0 1 1 0 2 2 2 0 ArsC family CDC37_N PF03234.9 KII64425.1 - 2.1 8.6 8.8 6.4 7.0 6.1 1.6 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding Syntaxin_2 PF14523.1 KII64425.1 - 2.8 8.0 11.8 2.6e+02 1.7 7.8 2.6 1 1 0 1 1 1 0 Syntaxin-like protein Ada3 PF10198.4 KII64425.1 - 3.4 7.4 8.9 4 7.1 1.2 2.1 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 DUF972 PF06156.8 KII64425.1 - 3.4 8.0 9.6 1.2 9.5 3.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) APG6 PF04111.7 KII64425.1 - 3.6 6.5 11.3 1.4 7.9 6.1 1.5 1 1 0 1 1 1 0 Autophagy protein Apg6 UPF0223 PF05256.7 KII64425.1 - 3.7 7.7 7.0 1.8 8.7 2.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0223) MSV199 PF10553.4 KII64425.1 - 4.2 7.2 13.0 2.6 7.9 5.8 2.0 1 1 1 2 2 2 0 MSV199 domain Atg14 PF10186.4 KII64425.1 - 4.7 6.0 10.3 11 4.8 7.1 1.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 KII64425.1 - 7.7 6.0 12.3 25 4.4 8.6 1.7 1 1 0 1 1 1 0 IncA protein AAA_23 PF13476.1 KII64425.1 - 9 6.5 15.6 13 6.0 10.8 1.1 1 0 0 1 1 1 0 AAA domain TMF_DNA_bd PF12329.3 KII64425.1 - 9.3 6.1 18.4 8.6 6.2 2.3 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding PurA PF04845.8 KII64426.1 - 1.9e-08 33.6 0.6 0.00014 21.0 0.1 2.1 1 1 0 2 2 2 2 PurA ssDNA and RNA-binding protein ALO PF04030.9 KII64426.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.4 2 0 0 2 2 2 0 D-arabinono-1,4-lactone oxidase zf-CCHC PF00098.18 KII64429.1 - 0.00031 20.5 0.3 0.00064 19.5 0.2 1.6 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII64429.1 - 0.0011 19.4 0.0 0.0015 19.0 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII64429.1 - 0.0076 16.0 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII64429.1 - 0.051 13.2 0.5 0.097 12.3 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle RVP PF00077.15 KII64429.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Perm-CXXC PF15629.1 KII64429.1 - 1.1 9.3 6.0 2.7 8.0 0.1 2.6 3 0 0 3 3 3 0 Permuted single zf-CXXC unit Imm30 PF15594.1 KII64431.1 - 0.076 13.1 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 30 DUF3770 PF12603.3 KII64431.1 - 0.097 11.7 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3770) rve PF00665.21 KII64432.1 - 3.2e-24 85.3 0.0 1.3e-23 83.4 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII64432.1 - 2.1e-23 82.8 0.5 8.2e-23 80.8 0.1 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII64432.1 - 1e-06 28.5 0.0 2.7e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.5 KII64432.1 - 0.00032 20.0 0.0 0.00069 18.9 0.0 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII64432.1 - 0.00088 18.7 0.1 0.0073 15.8 0.1 2.4 2 0 0 2 2 2 1 Integrase core domain DUF904 PF06005.7 KII64432.1 - 0.0048 17.1 3.2 0.5 10.6 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF904) zf-CCHC PF00098.18 KII64432.1 - 0.0072 16.2 5.3 0.4 10.7 0.5 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII64432.1 - 0.21 12.0 0.0 0.5 10.9 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease DUF2750 PF11042.3 KII64433.1 - 0.021 14.8 0.3 0.029 14.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2750) UBN2 PF14223.1 KII64433.1 - 0.047 13.4 0.2 0.086 12.6 0.1 1.5 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF2750 PF11042.3 KII64435.1 - 0.068 13.1 0.3 0.12 12.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2750) Sarcoglycan_1 PF04790.8 KII64437.1 - 0.074 12.2 0.4 0.079 12.1 0.3 1.1 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein RVT_1 PF00078.22 KII64438.1 - 3.9e-06 26.3 0.1 1.3e-05 24.6 0.1 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.1 KII64438.1 - 0.00025 21.5 0.0 0.00069 20.0 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII64438.1 - 0.00089 19.0 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII64438.1 - 0.027 14.3 0.0 0.17 11.8 0.0 2.3 1 1 1 2 2 2 0 Retroviral aspartyl protease rve PF00665.21 KII64440.1 - 0.023 14.8 0.1 0.093 12.8 0.0 1.9 1 1 0 1 1 1 0 Integrase core domain DDE_Tnp_IS1595 PF12762.2 KII64442.1 - 0.013 15.3 0.2 0.018 14.8 0.1 1.4 1 0 0 1 1 1 0 ISXO2-like transposase domain Peptidase_S24 PF00717.18 KII64445.1 - 5.6e-08 32.3 0.0 9.1e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Ded_cyto PF06920.8 KII64446.1 - 2.6e-19 69.2 1.0 4.7e-19 68.3 0.1 1.8 2 0 0 2 2 2 1 Dedicator of cytokinesis RNB PF00773.14 KII64447.1 - 1.9e-94 316.6 0.1 2.5e-94 316.2 0.1 1.2 1 0 0 1 1 1 1 RNB domain WD40 PF00400.27 KII64448.1 - 0.009 15.8 4.4 11 6.0 0.0 4.7 5 1 0 5 5 5 2 WD domain, G-beta repeat BBS2_Mid PF14783.1 KII64448.1 - 0.049 13.4 0.2 0.63 9.8 0.0 2.7 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.27 KII64449.1 - 0.00093 18.9 4.7 0.032 14.1 0.1 4.1 4 1 0 4 4 4 1 WD domain, G-beta repeat DUF1249 PF06853.7 KII64450.1 - 0.074 12.6 0.3 1 8.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1249) Homeobox PF00046.24 KII64452.1 - 5.3e-10 38.7 1.2 7.9e-10 38.2 0.8 1.3 1 0 0 1 1 1 1 Homeobox domain RVT_1 PF00078.22 KII64453.1 - 8.2e-18 64.5 0.0 2.2e-17 63.1 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII64453.1 - 3.2e-07 30.4 0.5 9.4e-06 25.7 0.3 2.7 1 1 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII64453.1 - 0.00031 20.5 7.8 0.0032 17.3 0.7 2.7 2 0 0 2 2 2 2 Zinc knuckle rve_3 PF13683.1 KII64453.1 - 0.0032 16.9 0.0 0.0091 15.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.1 KII64453.1 - 0.0066 16.0 8.0 0.11 12.1 0.9 2.8 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII64453.1 - 0.017 15.6 0.0 0.038 14.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII64453.1 - 0.21 11.4 0.0 0.51 10.2 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII64454.1 - 2.9e-06 26.9 1.9 2.9e-06 26.9 1.3 3.1 2 1 0 2 2 2 1 Zinc knuckle Mlo PF03094.10 KII64454.1 - 0.16 10.0 0.0 0.23 9.5 0.0 1.1 1 0 0 1 1 1 0 Mlo family rve PF00665.21 KII64455.1 - 2.3e-22 79.3 0.0 3.1e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII64455.1 - 5.1e-06 25.9 0.0 1.4e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Fer4 PF00037.22 KII64455.1 - 0.81 9.3 3.8 1.8 8.3 0.4 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain DEK_C PF08766.6 KII64457.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 DEK C terminal domain Plasmodium_Vir PF05795.6 KII64458.1 - 1.2e-05 24.7 2.1 1.4e-05 24.5 1.5 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein DUF912 PF06024.7 KII64458.1 - 0.00039 20.4 1.5 0.00065 19.7 1.0 1.4 1 1 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) MscS_TM PF12794.2 KII64458.1 - 0.024 13.2 0.7 0.031 12.9 0.5 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Rifin_STEVOR PF02009.11 KII64458.1 - 0.025 14.2 0.5 0.03 13.9 0.3 1.2 1 0 0 1 1 1 0 Rifin/stevor family Aa_trans PF01490.13 KII64458.1 - 0.029 12.8 0.8 0.036 12.5 0.6 1.1 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein TRAP_alpha PF03896.11 KII64458.1 - 0.07 12.1 0.7 0.081 11.9 0.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit EF-hand_10 PF14788.1 KII64458.1 - 0.07 12.7 0.1 0.17 11.5 0.1 1.7 1 0 0 1 1 1 0 EF hand DUF4558 PF15104.1 KII64458.1 - 0.32 10.9 0.1 0.32 10.9 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4558) Homeobox PF00046.24 KII64461.1 - 5.8e-12 45.0 5.8 9.6e-12 44.3 4.0 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox PF00046.24 KII64462.1 - 2.9e-11 42.7 1.3 6.7e-11 41.6 0.9 1.6 1 0 0 1 1 1 1 Homeobox domain MULE PF10551.4 KII64465.1 - 1.9e-06 27.9 0.5 3.9e-06 26.9 0.4 1.6 1 0 0 1 1 1 1 MULE transposase domain Hormone_3 PF00159.13 KII64465.1 - 9.9 6.2 9.0 11 6.1 0.0 2.9 3 0 0 3 3 3 0 Pancreatic hormone peptide Pox_F11 PF04943.7 KII64466.1 - 0.021 13.7 0.2 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 Poxvirus F11 protein MULE PF10551.4 KII64467.1 - 3.2e-08 33.6 2.1 8.6e-07 29.0 0.2 2.9 2 1 1 3 3 3 1 MULE transposase domain H_lectin PF09458.5 KII64467.1 - 0.013 15.1 0.2 0.037 13.6 0.1 1.7 1 0 0 1 1 1 0 H-type lectin domain PurA PF04845.8 KII64469.1 - 0.021 13.9 0.1 0.043 12.9 0.0 1.4 2 0 0 2 2 2 0 PurA ssDNA and RNA-binding protein Ldl_recept_a PF00057.13 KII64470.1 - 7.8e-07 28.8 8.7 7.8e-07 28.8 6.0 3.6 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A DUF4295 PF14128.1 KII64470.1 - 0.37 10.4 2.2 1.2 8.8 1.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4295) YolD PF08863.5 KII64471.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 YolD-like protein RRM_1 PF00076.17 KII64473.1 - 2.7e-25 87.7 0.6 3.6e-12 45.7 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII64473.1 - 1e-20 73.4 0.1 1.2e-09 37.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII64473.1 - 2e-08 33.9 0.0 3.9e-06 26.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NID PF07292.8 KII64473.1 - 0.055 13.5 0.0 0.38 10.8 0.0 2.4 3 1 0 3 3 3 0 Nmi/IFP 35 domain (NID) Swi5 PF07061.6 KII64474.1 - 4.7e-05 23.0 0.7 0.00063 19.4 0.1 2.4 2 1 0 2 2 2 1 Swi5 DUF1777 PF08648.7 KII64475.1 - 0.0021 17.8 24.5 0.0048 16.6 17.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1777) DUF1759 PF03564.10 KII64476.1 - 5e-14 52.3 5.8 7.8e-13 48.4 2.3 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF1759) eIF3g PF12353.3 KII64476.1 - 0.14 12.0 0.3 0.14 12.0 0.2 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.18 KII64476.1 - 0.59 10.1 17.0 0.67 10.0 3.7 3.6 3 0 0 3 3 3 0 Zinc knuckle DUF1758 PF05585.7 KII64477.1 - 3.3e-10 39.7 1.7 3.9e-10 39.5 1.2 1.1 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.1 KII64477.1 - 0.0015 19.0 0.0 0.0033 17.8 0.0 1.8 1 1 0 1 1 1 1 Aspartyl protease FtsA PF14450.1 KII64477.1 - 0.12 12.1 0.2 3.7 7.4 0.0 2.2 2 0 0 2 2 2 0 Cell division protein FtsA Peptidase_A17 PF05380.8 KII64478.1 - 3.4e-34 117.9 0.0 7.1e-34 116.9 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase RNase_H PF00075.19 KII64478.1 - 0.00022 21.5 0.0 0.001 19.3 0.0 2.2 3 0 0 3 3 3 1 RNase H DUF621 PF04789.10 KII64480.1 - 0.013 14.4 0.6 0.013 14.4 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF621) RNase_PH PF01138.16 KII64481.1 - 1.6e-17 64.0 0.3 1.1e-09 38.7 0.0 2.6 2 1 1 3 3 3 2 3' exoribonuclease family, domain 1 Thymosin PF01290.15 KII64482.1 - 3.5e-47 157.7 42.7 2.2e-08 33.5 0.3 7.1 4 3 3 7 7 7 7 Thymosin beta-4 family QueF PF14489.1 KII64482.1 - 0.0059 16.5 0.1 1.7 8.6 0.0 2.8 2 0 0 2 2 2 2 QueF-like protein RNA_pol_Rpb1_4 PF05000.12 KII64482.1 - 0.043 13.5 0.0 0.17 11.6 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 4 DUF4522 PF15022.1 KII64482.1 - 0.34 10.6 4.3 2.5 7.8 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4522) WH2 PF02205.15 KII64482.1 - 0.55 9.9 15.5 0.25 10.9 0.2 5.0 5 0 0 5 5 5 0 WH2 motif FmdE PF02663.9 KII64484.1 - 0.096 12.5 0.2 0.31 10.9 0.1 1.9 1 1 1 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Ank_2 PF12796.2 KII64485.1 - 4.5e-97 318.5 28.0 2.8e-19 69.2 0.8 8.9 2 1 6 10 10 10 9 Ankyrin repeats (3 copies) Ank PF00023.25 KII64485.1 - 1.2e-87 283.5 27.0 1.1e-08 34.4 0.0 16.3 15 1 0 15 15 15 15 Ankyrin repeat Ank_4 PF13637.1 KII64485.1 - 3.2e-75 247.2 24.3 4.1e-12 46.2 0.0 12.6 7 4 7 14 14 14 13 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII64485.1 - 5.2e-69 226.7 27.7 1.1e-08 35.0 0.0 14.5 5 3 11 16 16 16 14 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII64485.1 - 7.1e-69 220.8 35.1 1.5e-05 24.7 0.0 19.1 20 0 0 20 20 20 15 Ankyrin repeat DDE_3 PF13358.1 KII64486.1 - 0.0018 18.0 0.1 0.0038 16.9 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease 2OG-FeII_Oxy PF03171.15 KII64487.1 - 5.2e-08 33.0 0.0 7.6e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KII64487.1 - 2.6e-05 24.6 0.0 4.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily P4Ha_N PF08336.6 KII64488.1 - 7.1e-15 55.0 0.2 2e-14 53.5 0.1 1.8 1 1 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region APG6 PF04111.7 KII64489.1 - 1.5e-35 122.8 4.5 2.7e-35 121.9 3.1 1.5 1 1 0 1 1 1 1 Autophagy protein Apg6 EMP24_GP25L PF01105.19 KII64492.1 - 3.9e-14 52.7 0.1 4.6e-14 52.5 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2201_N PF13203.1 KII64493.1 - 3.1 6.8 11.3 4 6.5 7.8 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Trypan_PARP PF05887.6 KII64493.1 - 5.3 6.8 19.4 9.8 5.9 13.5 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DDE_1 PF03184.14 KII64494.1 - 0.0042 16.2 0.3 0.0078 15.3 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease CYTL1 PF15153.1 KII64495.1 - 0.071 12.8 0.0 0.13 11.9 0.0 1.4 1 1 0 1 1 1 0 Cytokine-like protein 1 Suppressor_APC PF11414.3 KII64495.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein Mito_fiss_reg PF05308.6 KII64496.1 - 0.24 10.7 9.2 0.29 10.4 6.4 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Adenylsucc_synt PF00709.16 KII64496.1 - 8.5 4.9 9.5 10 4.6 6.6 1.2 1 0 0 1 1 1 0 Adenylosuccinate synthetase CorA PF01544.13 KII64496.1 - 9.9 5.0 10.7 12 4.8 7.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein BTP PF05232.7 KII64497.1 - 6.7e-28 96.2 10.8 2.2e-19 68.9 4.8 2.0 2 0 0 2 2 2 2 Bacterial Transmembrane Pair family Oxidored_q4 PF00507.14 KII64497.1 - 0.47 10.2 6.0 0.47 10.3 3.8 1.3 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GtrA PF04138.9 KII64497.1 - 0.63 10.0 6.3 1.1 9.2 4.4 1.4 1 1 0 1 1 1 0 GtrA-like protein CLP_protease PF00574.18 KII64498.1 - 7.7e-16 58.2 0.0 9.8e-16 57.9 0.0 1.0 1 0 0 1 1 1 1 Clp protease EB1 PF03271.12 KII64498.1 - 0.036 14.1 0.1 0.07 13.1 0.1 1.5 1 0 0 1 1 1 0 EB1-like C-terminal motif Glyco_hydro_4C PF11975.3 KII64499.1 - 8.1e-60 202.5 0.1 1.3e-59 201.7 0.1 1.3 1 1 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain Glyco_hydro_4 PF02056.11 KII64499.1 - 0.00065 19.0 0.5 0.0012 18.1 0.4 1.5 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Glyco_hydro_4 PF02056.11 KII64500.1 - 8.5e-36 122.9 0.1 9.5e-36 122.8 0.1 1.0 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase DDE_3 PF13358.1 KII64501.1 - 3e-11 43.2 0.0 3.9e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII64501.1 - 0.0006 19.0 0.0 0.00071 18.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease MNE1 PF13762.1 KII64501.1 - 0.065 13.3 0.6 0.51 10.4 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial splicing apparatus component RIH_assoc PF08454.6 KII64501.1 - 0.18 11.4 1.7 0.25 10.9 0.4 1.7 2 0 0 2 2 2 0 RyR and IP3R Homology associated DUF3144 PF11342.3 KII64502.1 - 0.08 13.0 0.4 1.1 9.3 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3144) ChlamPMP_M PF07548.6 KII64502.1 - 0.092 12.4 0.2 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Chlamydia polymorphic membrane protein middle domain DUF3199 PF11436.3 KII64502.1 - 0.095 12.5 1.7 0.5 10.2 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3199) Adaptin_N PF01602.15 KII64503.1 - 0.0058 15.0 0.6 0.027 12.8 0.0 2.1 2 0 0 2 2 2 1 Adaptin N terminal region CTD_bind PF04818.8 KII64503.1 - 0.054 13.7 0.0 0.35 11.1 0.0 2.5 1 0 0 1 1 1 0 RNA polymerase II-binding domain. CBM_11 PF03425.8 KII64508.1 - 0.027 14.1 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) DDE_Tnp_IS1595 PF12762.2 KII64511.1 - 3.4e-11 43.2 0.0 7e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain ApoB100_C PF12491.3 KII64511.1 - 0.0061 16.1 0.1 0.25 11.0 0.0 2.8 3 0 0 3 3 3 1 Apolipoprotein B100 C terminal Integrin_beta PF00362.13 KII64512.1 - 0.022 13.6 0.0 0.024 13.5 0.0 1.1 1 0 0 1 1 1 0 Integrin, beta chain rve PF00665.21 KII64513.1 - 1.7e-17 63.6 0.1 2.5e-17 63.0 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII64513.1 - 0.021 14.3 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.22 KII64514.1 - 1.3e-15 57.3 0.1 6.3e-15 55.1 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII64514.1 - 1.7e-07 31.0 0.2 4.4e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII64514.1 - 2.9e-06 27.6 0.0 7.1e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII64514.1 - 4e-06 26.5 0.0 1e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII64514.1 - 0.0039 17.1 0.0 0.0079 16.1 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII64514.1 - 0.014 14.9 0.0 0.036 13.6 0.0 1.6 2 0 0 2 2 2 0 Aspartyl protease RNase_H PF00075.19 KII64514.1 - 0.063 13.6 0.1 0.61 10.4 0.0 2.5 3 0 0 3 3 3 0 RNase H RPAP1_N PF08621.5 KII64516.1 - 0.15 11.6 0.1 0.29 10.7 0.1 1.4 1 0 0 1 1 1 0 RPAP1-like, N-terminal FANCI_S3 PF14677.1 KII64517.1 - 0.076 12.3 0.1 0.097 12.0 0.1 1.1 1 0 0 1 1 1 0 FANCI solenoid 3 DUF4573 PF15140.1 KII64518.1 - 7.1e-07 28.9 4.2 4.6e-06 26.3 2.9 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4573) Nucleoside_tran PF01733.13 KII64519.1 - 0.24 10.5 1.1 0.24 10.5 0.8 1.1 1 0 0 1 1 1 0 Nucleoside transporter ABC2_membrane_3 PF12698.2 KII64519.1 - 1.6 7.6 4.1 1.8 7.4 2.9 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DNA_pol_B_3 PF08408.5 KII64523.1 - 0.06 13.2 0.0 0.092 12.6 0.0 1.3 1 1 0 1 1 1 0 DNA polymerase family B viral insert DUF4451 PF14616.1 KII64523.1 - 0.063 13.0 0.3 0.074 12.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) IncA PF04156.9 KII64527.1 - 0.053 13.1 1.0 1.5 8.3 0.7 2.1 1 1 0 1 1 1 0 IncA protein DUF1725 PF08333.6 KII64527.1 - 0.53 9.6 102.8 55 3.2 0.0 24.9 2 1 25 27 27 27 0 Protein of unknown function (DUF1725) Prolamin_like PF05617.6 KII64530.1 - 0.1 12.7 1.2 0.22 11.6 0.8 1.6 1 1 0 1 1 1 0 Prolamin-like RNA_pol_Rpb1_5 PF04998.12 KII64531.1 - 4.9e-102 340.9 0.1 8.3e-102 340.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 KII64531.1 - 1.9e-100 336.3 0.0 3.4e-100 335.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 KII64531.1 - 7.8e-68 227.6 0.0 1.7e-67 226.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 KII64531.1 - 5.3e-63 212.1 0.6 8.9e-63 211.4 0.4 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 KII64531.1 - 3.4e-49 166.5 0.4 1.2e-47 161.5 0.0 2.9 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 KII64531.1 - 1.6e-44 150.8 5.4 3.8e-44 149.6 3.7 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 KII64531.1 - 7.4e-36 122.1 0.1 1.6e-35 121.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 XET_C PF06955.7 KII64531.1 - 0.0019 17.8 1.1 0.0045 16.6 0.8 1.6 1 0 0 1 1 1 1 Xyloglucan endo-transglycosylase (XET) C-terminus Aconitase PF00330.15 KII64532.1 - 1.4e-08 33.6 0.2 1.7e-08 33.3 0.2 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Takusan PF04822.8 KII64532.1 - 0.095 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Takusan Na_sulph_symp PF00939.14 KII64533.1 - 1.2e-47 162.9 5.5 1.3e-47 162.8 3.8 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region HTH_15 PF12324.3 KII64535.1 - 0.18 11.5 1.2 0.34 10.5 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase LysR_substrate PF03466.15 KII64536.1 - 3.2e-21 75.4 0.0 4.1e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.22 KII64536.1 - 1.2e-11 44.1 0.7 3.4e-11 42.7 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family DUF1191 PF06697.7 KII64541.1 - 0.022 13.5 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Herpes_UL45 PF05473.7 KII64541.1 - 0.86 8.9 3.9 0.91 8.9 2.7 1.3 1 1 0 1 1 1 0 UL45 protein Claudin_2 PF13903.1 KII64542.1 - 0.23 11.1 10.4 0.34 10.6 6.4 1.9 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF4225 PF13988.1 KII64542.1 - 0.63 9.4 4.5 0.89 8.9 2.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4225) Glycoprotein_B PF00606.13 KII64542.1 - 3.3 5.6 6.6 4.6 5.1 4.5 1.1 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B Metallophos PF00149.23 KII64543.1 - 1.2e-10 41.1 1.3 2.2e-10 40.2 0.9 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase HTH_38 PF13936.1 KII64544.1 - 0.00068 19.1 3.5 0.055 13.0 0.2 2.5 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII64544.1 - 0.00079 19.4 0.6 0.0014 18.5 0.4 1.5 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.1 KII64544.1 - 0.0024 17.9 0.1 0.0043 17.1 0.0 1.4 1 1 0 1 1 1 1 Winged helix-turn helix GerE PF00196.14 KII64544.1 - 0.0059 15.8 0.3 0.014 14.6 0.2 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_23 PF13384.1 KII64544.1 - 0.014 15.0 0.3 0.11 12.1 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain Sigma70_r4_2 PF08281.7 KII64544.1 - 0.1 12.0 0.0 0.26 10.8 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_28 PF13518.1 KII64544.1 - 0.13 12.2 0.9 0.22 11.5 0.2 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_19 PF12844.2 KII64544.1 - 0.33 11.0 1.9 0.51 10.4 0.5 2.0 1 1 0 1 1 1 0 Helix-turn-helix domain DDE_3 PF13358.1 KII64545.1 - 7.9e-09 35.4 0.0 9.8e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4448 PF14610.1 KII64546.1 - 0.0081 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF2510 PF10708.4 KII64547.1 - 0.009 15.4 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2510) Enkurin PF13864.1 KII64547.1 - 5.2 7.3 13.9 3 8.1 1.3 3.3 3 0 0 3 3 3 0 Calmodulin-binding Dpy19 PF10034.4 KII64548.1 - 0.012 13.8 0.1 0.012 13.8 0.1 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Peptidase_S39 PF02122.10 KII64549.1 - 0.094 12.0 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase S39 zf-CCHC PF00098.18 KII64550.1 - 1.7e-05 24.5 2.1 2.9e-05 23.7 1.4 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 KII64550.1 - 0.1 12.2 2.0 0.31 10.7 1.4 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.18 KII64553.1 - 0.0025 17.6 1.0 0.0029 17.4 0.0 1.6 2 0 0 2 2 2 1 Zinc knuckle DUF320 PF03777.8 KII64553.1 - 0.096 12.4 0.1 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Small secreted domain (DUF320) Daxx PF03344.10 KII64554.1 - 6.7e-08 31.5 10.9 9.3e-08 31.0 7.6 1.2 1 0 0 1 1 1 1 Daxx Family RNA_pol_Rpb5_N PF03871.9 KII64554.1 - 0.56 10.6 5.9 0.24 11.8 0.9 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb5, N-terminal domain DDE_3 PF13358.1 KII64555.1 - 8e-10 38.6 0.0 4.6e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HNH_2 PF13391.1 KII64555.1 - 0.096 12.4 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 HNH endonuclease LRR_1 PF00560.28 KII64557.1 - 0.0019 17.9 1.4 1 9.6 0.2 3.0 3 0 0 3 3 3 2 Leucine Rich Repeat DUF3884 PF13024.1 KII64558.1 - 0.0014 18.0 0.2 0.0021 17.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3884) DnaJ_CXXCXGXG PF00684.14 KII64558.1 - 0.059 13.4 0.2 0.086 12.9 0.2 1.3 1 0 0 1 1 1 0 DnaJ central domain PLDc_N PF13396.1 KII64559.1 - 0.047 13.3 1.4 0.1 12.2 0.9 1.5 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal ADAM_spacer1 PF05986.9 KII64559.1 - 0.12 12.2 0.2 0.23 11.3 0.1 1.6 1 1 0 1 1 1 0 ADAM-TS Spacer 1 PLDc_N PF13396.1 KII64561.1 - 0.0053 16.4 1.3 0.014 15.0 1.1 1.5 2 0 0 2 2 2 1 Phospholipase_D-nuclease N-terminal PLDc_N PF13396.1 KII64564.1 - 0.15 11.7 3.9 0.22 11.2 1.5 2.1 2 1 0 2 2 2 0 Phospholipase_D-nuclease N-terminal Glyco_hydro_7 PF00840.15 KII64564.1 - 0.2 10.0 2.3 0.22 9.8 1.6 1.3 1 1 0 1 1 1 0 Glycosyl hydrolase family 7 DUF960 PF06124.6 KII64565.1 - 0.079 13.2 2.3 5 7.4 0.2 2.3 2 0 0 2 2 2 0 Staphylococcal protein of unknown function (DUF960) RVT_1 PF00078.22 KII64568.1 - 1.8e-12 47.0 0.0 2.8e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CarboxypepD_reg PF13620.1 KII64571.1 - 0.07 13.1 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain SNAP PF14938.1 KII64572.1 - 2.6e-17 62.8 0.5 3.4e-17 62.5 0.4 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII64572.1 - 0.00078 19.3 2.5 5.1 7.1 0.1 3.6 2 1 2 4 4 4 3 Tetratricopeptide repeat Foie-gras_1 PF11817.3 KII64572.1 - 0.0087 15.5 0.2 0.017 14.6 0.1 1.4 1 0 0 1 1 1 1 Foie gras liver health family 1 TPR_19 PF14559.1 KII64572.1 - 0.071 13.4 0.1 0.32 11.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 KII64572.1 - 0.1 12.7 0.1 0.1 12.7 0.1 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 KII64572.1 - 0.11 12.5 10.0 1.1 9.3 0.1 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat Cytidylate_kin2 PF13189.1 KII64575.1 - 0.089 12.6 0.1 0.13 12.1 0.0 1.4 1 1 0 1 1 1 0 Cytidylate kinase-like family EST1_DNA_bind PF10373.4 KII64576.1 - 0.042 13.0 0.3 0.1 11.8 0.2 1.6 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain Mito_carr PF00153.22 KII64578.1 - 7e-49 163.5 7.4 9.4e-20 70.1 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein FtsJ PF01728.14 KII64580.1 - 3.8e-49 167.1 0.1 4.3e-49 166.9 0.1 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 KII64580.1 - 0.00036 21.0 0.0 0.009 16.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KII64580.1 - 0.03 13.9 0.0 0.038 13.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Ald_Xan_dh_C PF01315.17 KII64580.1 - 0.089 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Ubie_methyltran PF01209.13 KII64580.1 - 0.1 11.6 0.1 0.26 10.3 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family NSP13 PF06460.7 KII64581.1 - 0.015 14.1 0.6 0.27 10.0 0.3 2.0 2 0 0 2 2 2 0 Coronavirus NSP13 WD40 PF00400.27 KII64581.1 - 0.12 12.2 0.1 14 5.7 0.0 2.5 2 0 0 2 2 2 0 WD domain, G-beta repeat Orbi_VP4 PF05059.7 KII64582.1 - 0.081 10.6 0.0 0.085 10.6 0.0 1.0 1 0 0 1 1 1 0 Orbivirus VP4 core protein DDE_Tnp_IS1595 PF12762.2 KII64585.1 - 3.9e-12 46.2 0.0 5.8e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF4371 PF14291.1 KII64585.1 - 0.014 14.9 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) DLIC PF05783.6 KII64586.1 - 2.3e-19 69.4 0.0 8.1e-09 34.6 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) MMR_HSR1 PF01926.18 KII64586.1 - 0.0013 18.7 0.0 0.0027 17.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 KII64586.1 - 0.0086 15.5 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family GTP_EFTU PF00009.22 KII64586.1 - 0.0088 15.4 0.0 1.8 7.9 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 KII64586.1 - 0.0099 16.6 0.0 0.026 15.3 0.0 2.0 2 1 0 2 2 1 1 AAA domain SRPRB PF09439.5 KII64586.1 - 0.01 15.0 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 KII64586.1 - 0.014 14.8 0.0 0.061 12.8 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.1 KII64586.1 - 0.02 15.1 0.3 0.13 12.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.1 KII64586.1 - 0.026 14.6 0.0 0.066 13.3 0.0 1.8 2 1 0 2 2 2 0 AAA domain Arf PF00025.16 KII64586.1 - 0.031 13.5 0.0 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family FeoB_N PF02421.13 KII64586.1 - 0.032 13.4 1.4 0.034 13.4 0.0 1.7 2 0 0 2 2 1 0 Ferrous iron transport protein B Septin PF00735.13 KII64586.1 - 0.037 13.0 0.0 0.074 12.0 0.0 1.4 1 0 0 1 1 1 0 Septin Miro PF08477.8 KII64586.1 - 0.042 14.3 0.0 0.083 13.3 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_14 PF13173.1 KII64586.1 - 0.045 13.6 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KII64586.1 - 0.064 12.6 0.0 0.18 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain AAA_16 PF13191.1 KII64586.1 - 0.066 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain T2SE PF00437.15 KII64586.1 - 0.1 11.4 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein LysE PF01810.13 KII64586.1 - 0.13 11.5 0.1 1.7 7.8 0.0 2.1 2 0 0 2 2 2 0 LysE type translocator GNT-I PF03071.10 KII64590.1 - 1.3e-05 24.0 1.3 2.7e-05 22.9 0.7 1.8 1 1 0 1 1 1 1 GNT-I family MGAT2 PF05060.9 KII64590.1 - 0.0022 16.9 0.1 0.0025 16.7 0.1 1.2 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) HMG_CoA_synt_N PF01154.12 KII64592.1 - 7.2e-61 204.7 0.2 1.1e-60 204.2 0.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.5 KII64592.1 - 2.3e-08 33.8 1.9 3.7e-08 33.1 1.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal Oxidored_molyb PF00174.14 KII64593.1 - 2.8e-43 147.2 0.0 1.2e-42 145.2 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Cyt-b5 PF00173.23 KII64593.1 - 2.9e-17 62.2 0.1 4.8e-17 61.5 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RVP PF00077.15 KII64594.1 - 1.5e-06 28.0 0.0 2.5e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII64594.1 - 0.028 14.2 0.0 0.049 13.4 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Radical_SAM PF04055.16 KII64596.1 - 2.7e-16 60.1 0.0 3.7e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily La PF05383.12 KII64597.1 - 1.2e-07 31.4 0.1 1.8e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 La domain Integrin_beta PF00362.13 KII64598.1 - 2.3e-09 36.6 0.5 7.5e-06 25.0 0.0 2.0 1 1 1 2 2 2 2 Integrin, beta chain DUF1374 PF07118.6 KII64598.1 - 0.03 14.4 1.5 0.57 10.3 0.0 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1374) MotA_activ PF09114.5 KII64598.1 - 0.077 12.7 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Transcription factor MotA, activation domain Serpin PF00079.15 KII64599.1 - 5.8e-05 22.3 0.2 6.3e-05 22.2 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sugar_tr PF00083.19 KII64600.1 - 0.0092 14.6 0.0 0.01 14.4 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Sugar_tr PF00083.19 KII64601.1 - 1.2e-24 86.7 15.9 1.5e-24 86.4 11.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Clc-like PF07062.7 KII64601.1 - 0.032 13.4 0.3 0.032 13.4 0.2 1.8 3 0 0 3 3 3 0 Clc-like Ribosom_S12_S23 PF00164.20 KII64602.1 - 7.2e-32 109.3 3.5 8.4e-32 109.1 2.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 eIF-1a PF01176.14 KII64602.1 - 0.06 12.7 0.1 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 DUF1661 PF07877.6 KII64602.1 - 0.069 12.6 0.1 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1661) Tautomerase PF01361.16 KII64602.1 - 0.093 12.3 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Tautomerase enzyme BDV_P24 PF06595.6 KII64603.1 - 0.034 13.9 0.5 0.043 13.5 0.3 1.1 1 0 0 1 1 1 0 Borna disease virus P24 protein HJURP_C PF12347.3 KII64603.1 - 0.042 13.4 0.9 0.075 12.6 0.2 1.8 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat DUF3473 PF11959.3 KII64603.1 - 0.08 12.3 0.2 0.46 9.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3473) DUF1104 PF06518.6 KII64603.1 - 0.086 12.9 5.1 0.33 11.1 1.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1104) AAA_29 PF13555.1 KII64604.1 - 0.0011 18.3 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SE PF00437.15 KII64604.1 - 0.0038 16.1 0.0 0.0038 16.1 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein UPF0079 PF02367.12 KII64604.1 - 0.01 15.4 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 ABC_tran PF00005.22 KII64604.1 - 0.012 15.8 0.1 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.1 KII64604.1 - 0.029 14.7 0.1 0.053 13.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.7 KII64604.1 - 0.029 13.6 0.1 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein PhoH PF02562.11 KII64604.1 - 0.052 12.7 0.0 0.072 12.3 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.1 KII64604.1 - 0.069 12.5 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 KII64604.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase ResIII PF04851.10 KII64604.1 - 0.11 12.3 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.13 KII64604.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_19 PF13245.1 KII64604.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain HA2 PF04408.18 KII64605.1 - 4.4e-24 84.4 0.1 7.5e-24 83.7 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 KII64605.1 - 2.9e-22 78.6 0.3 4.1e-22 78.1 0.2 1.4 1 1 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Band_7 PF01145.20 KII64607.1 - 1.3e-22 80.5 3.7 1.9e-22 80.0 2.5 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.3 KII64607.1 - 0.0033 17.4 0.9 0.0058 16.6 0.6 1.4 1 0 0 1 1 1 1 Mediator complex subunit 2 DUF3334 PF11813.3 KII64607.1 - 0.083 12.4 1.3 0.12 11.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3334) AAA_17 PF13207.1 KII64609.1 - 4.4e-06 27.5 0.8 2.3e-05 25.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain Mrr_cat PF04471.7 KII64609.1 - 1.9e-05 24.4 0.0 4.8e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Restriction endonuclease AAA_18 PF13238.1 KII64609.1 - 0.00011 22.4 2.1 0.00011 22.4 1.5 4.0 3 1 1 4 4 4 1 AAA domain AAA_14 PF13173.1 KII64609.1 - 0.00026 20.9 0.4 0.00026 20.9 0.3 3.5 2 1 2 4 4 3 1 AAA domain DUF258 PF03193.11 KII64609.1 - 0.00032 19.9 0.0 0.00062 18.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 PhoH PF02562.11 KII64609.1 - 0.00049 19.3 0.1 0.0011 18.2 0.1 1.6 1 0 0 1 1 1 1 PhoH-like protein NACHT PF05729.7 KII64609.1 - 0.00073 19.2 0.2 0.0043 16.7 0.1 2.4 2 1 1 3 3 2 1 NACHT domain AAA_30 PF13604.1 KII64609.1 - 0.0012 18.4 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 KII64609.1 - 0.0013 17.6 0.0 0.0025 16.7 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_28 PF13521.1 KII64609.1 - 0.0018 18.2 0.0 0.0048 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII64609.1 - 0.002 18.1 0.0 0.0046 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Parvo_NS1 PF01057.12 KII64609.1 - 0.0023 16.8 0.0 0.0078 15.1 0.0 1.8 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_22 PF13401.1 KII64609.1 - 0.0024 18.0 0.0 0.0083 16.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KII64609.1 - 0.0031 17.2 0.0 0.016 14.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 KII64609.1 - 0.0033 16.9 0.1 0.012 15.0 0.0 2.1 1 1 1 2 2 2 1 AAA-like domain NB-ARC PF00931.17 KII64609.1 - 0.0038 16.1 0.4 0.011 14.5 0.1 1.9 1 1 1 2 2 2 1 NB-ARC domain IstB_IS21 PF01695.12 KII64609.1 - 0.0041 16.5 0.6 0.02 14.2 0.0 2.4 4 0 0 4 4 3 1 IstB-like ATP binding protein NTPase_1 PF03266.10 KII64609.1 - 0.0081 15.8 0.3 0.025 14.2 0.1 1.9 2 0 0 2 2 2 1 NTPase AAA_25 PF13481.1 KII64609.1 - 0.011 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 KII64609.1 - 0.013 15.0 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.1 KII64609.1 - 0.019 14.7 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain RNA_helicase PF00910.17 KII64609.1 - 0.025 14.7 0.0 0.084 13.0 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.1 KII64609.1 - 0.03 13.8 0.0 0.1 12.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA PF00004.24 KII64609.1 - 0.037 14.2 0.0 0.15 12.2 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ndr PF03096.9 KII64609.1 - 0.037 12.4 0.0 0.084 11.3 0.0 1.5 1 0 0 1 1 1 0 Ndr family ABC_tran PF00005.22 KII64609.1 - 0.044 14.0 1.2 0.14 12.4 0.9 2.0 1 1 0 1 1 1 0 ABC transporter SRP54 PF00448.17 KII64609.1 - 0.053 12.9 0.0 0.37 10.2 0.0 2.4 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain RuvB_N PF05496.7 KII64609.1 - 0.065 12.2 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Sigma54_activ_2 PF14532.1 KII64609.1 - 0.067 13.2 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.1 KII64609.1 - 0.16 11.8 0.0 0.4 10.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KII64609.1 - 5.3 7.3 12.5 0.1 12.9 2.2 2.5 2 1 0 2 2 2 0 AAA domain ARS2 PF04959.8 KII64612.1 - 9.2e-22 78.2 1.0 1.2e-21 77.9 0.0 1.6 2 0 0 2 2 2 1 Arsenite-resistance protein 2 DUF3546 PF12066.3 KII64612.1 - 4.6e-15 55.5 0.4 1.1e-14 54.3 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) DUF629 PF04780.7 KII64612.1 - 0.012 14.1 0.1 0.029 12.8 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF629) DDE_3 PF13358.1 KII64613.1 - 8.4e-29 100.1 0.0 1.2e-24 86.7 0.0 2.8 3 0 0 3 3 3 2 DDE superfamily endonuclease rve PF00665.21 KII64613.1 - 3.8e-28 97.9 0.0 1.7e-24 86.1 0.0 3.2 3 0 0 3 3 3 2 Integrase core domain HTH_29 PF13551.1 KII64613.1 - 4.8e-09 36.3 0.0 9.4e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_33 PF13592.1 KII64613.1 - 8.6e-06 25.2 0.0 2.7e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII64613.1 - 6.1e-05 23.0 0.7 0.00037 20.4 0.1 2.7 2 0 0 2 2 2 1 Transposase rve_3 PF13683.1 KII64613.1 - 7.4e-05 22.1 0.0 0.00024 20.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain HTH_11 PF08279.7 KII64613.1 - 0.0002 20.9 0.7 0.43 10.2 0.1 2.9 2 0 0 2 2 2 2 HTH domain HTH_23 PF13384.1 KII64613.1 - 0.0003 20.3 0.0 0.33 10.6 0.0 2.6 2 0 0 2 2 2 2 Homeodomain-like domain PAX PF00292.13 KII64613.1 - 0.00038 20.1 0.2 0.00083 19.0 0.1 1.5 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.1 KII64613.1 - 0.00093 19.9 0.1 0.0024 18.6 0.0 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.1 KII64613.1 - 0.0031 16.8 0.8 0.027 13.8 0.0 2.7 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_Tnp_IS630 PF01710.11 KII64613.1 - 0.0089 15.7 0.1 0.019 14.5 0.1 1.5 1 0 0 1 1 1 1 Transposase TrmB PF01978.14 KII64613.1 - 0.013 15.1 0.0 0.23 11.1 0.0 2.7 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.1 KII64613.1 - 0.018 15.0 0.0 1.2 9.1 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.1 KII64613.1 - 0.059 12.9 0.5 1.1 8.8 0.1 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.15 KII64613.1 - 0.061 13.2 0.0 0.33 10.9 0.0 2.2 2 0 0 2 2 2 0 Transposase Sigma70_r4_2 PF08281.7 KII64613.1 - 0.073 12.5 0.0 0.23 10.9 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 Arg_repressor PF01316.16 KII64613.1 - 0.088 12.3 0.0 0.26 10.8 0.0 1.7 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_DeoR PF08220.7 KII64613.1 - 0.095 12.2 0.4 0.41 10.2 0.0 2.2 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain Snf7 PF03357.16 KII64614.1 - 3.4e-25 88.3 13.4 4.2e-25 88.0 9.3 1.1 1 0 0 1 1 1 1 Snf7 NYD-SP28 PF14772.1 KII64614.1 - 0.031 14.3 2.1 0.031 14.3 1.5 2.2 2 1 0 2 2 2 0 Sperm tail LcrG PF07216.7 KII64614.1 - 0.18 11.8 1.6 0.59 10.1 0.2 2.2 1 1 1 2 2 2 0 LcrG protein UvrD-helicase PF00580.16 KII64614.1 - 0.39 9.9 10.4 0.17 11.1 3.2 2.0 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain DUF327 PF03885.8 KII64614.1 - 3.4 7.5 12.7 0.045 13.5 1.4 2.7 1 1 1 3 3 3 0 Protein of unknown function (DUF327) hGDE_central PF14702.1 KII64615.1 - 4.5e-25 88.3 0.2 6.4e-25 87.8 0.1 1.2 1 0 0 1 1 1 1 central domain of human glycogen debranching enzyme GDE_C PF06202.9 KII64617.1 - 1.1e-60 205.3 0.0 1.2e-60 205.1 0.0 1.0 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase EF-hand_7 PF13499.1 KII64618.1 - 7.4e-24 83.6 19.9 8.5e-09 35.4 0.7 4.1 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KII64618.1 - 2.5e-23 79.5 21.1 0.00045 19.3 0.0 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KII64618.1 - 1.6e-21 74.1 16.2 0.0023 17.6 0.0 6.5 6 1 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.1 KII64618.1 - 1.4e-15 55.7 16.9 0.0083 15.4 0.0 6.4 6 0 0 6 6 6 5 EF hand SPARC_Ca_bdg PF10591.4 KII64618.1 - 5.3e-11 42.5 11.8 0.00016 21.6 0.3 3.6 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.1 KII64618.1 - 1.7e-09 37.1 17.2 0.06 12.9 0.1 5.6 4 2 2 6 6 6 5 EF-hand domain pair EF-hand_like PF09279.6 KII64618.1 - 0.0022 17.9 4.7 0.05 13.6 0.2 3.2 2 2 2 4 4 4 1 Phosphoinositide-specific phospholipase C, efhand-like Utp21 PF04192.7 KII64618.1 - 0.028 13.5 0.0 0.052 12.6 0.0 1.3 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain EF-hand_4 PF12763.2 KII64618.1 - 0.035 13.8 4.8 3.2 7.5 0.0 3.5 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand SLT_beta PF02258.11 KII64618.1 - 0.23 11.3 1.4 0.55 10.1 1.0 1.6 1 0 0 1 1 1 0 Shiga-like toxin beta subunit EF-hand_10 PF14788.1 KII64618.1 - 0.51 10.0 8.4 5.6 6.7 0.2 4.4 5 1 1 6 6 6 0 EF hand Dockerin_1 PF00404.13 KII64618.1 - 6.5 6.6 9.2 8.6 6.2 0.8 3.0 3 0 0 3 3 3 0 Dockerin type I repeat UCH PF00443.24 KII64621.1 - 2.7e-33 115.2 0.3 5.1e-33 114.3 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KII64621.1 - 2.5e-08 33.7 0.0 4.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TRAM_LAG1_CLN8 PF03798.11 KII64622.1 - 8.9e-17 61.2 8.7 8.9e-17 61.2 6.1 2.0 2 0 0 2 2 2 1 TLC domain Toxin_10 PF05431.6 KII64623.1 - 0.17 11.5 1.0 0.36 10.4 0.4 1.6 2 0 0 2 2 2 0 Insecticidal Crystal Toxin, P42 Aldedh PF00171.17 KII64624.1 - 4.2e-10 38.5 0.0 4.8e-10 38.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rep_fac-A_3 PF08661.6 KII64625.1 - 0.00049 19.9 0.0 0.0006 19.6 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 WHH PF14414.1 KII64626.1 - 0.076 12.2 0.8 0.13 11.4 0.6 1.4 1 0 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved WHH DASH_Dad2 PF08654.5 KII64628.1 - 0.0046 16.9 0.3 0.0063 16.5 0.2 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad2 DUF1366 PF07104.6 KII64628.1 - 0.0063 16.1 1.2 0.0076 15.8 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1366) DUF4200 PF13863.1 KII64628.1 - 0.017 15.0 2.3 0.02 14.8 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF3557 PF12078.3 KII64628.1 - 0.032 13.9 0.1 0.034 13.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3557) NPV_P10 PF05531.7 KII64628.1 - 0.044 14.0 0.2 0.063 13.5 0.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein YkyA PF10368.4 KII64628.1 - 0.044 13.1 2.0 0.052 12.8 1.4 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein MbeB_N PF04837.7 KII64628.1 - 0.052 13.6 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 MbeB-like, N-term conserved region DUF2999 PF11212.3 KII64628.1 - 0.059 13.4 0.1 0.088 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2999) DASH_Dad3 PF08656.5 KII64628.1 - 0.061 13.0 0.2 0.091 12.4 0.1 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad3 AAA PF00004.24 KII64629.1 - 7.8e-17 61.7 0.0 1.2e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KII64629.1 - 1.2e-07 31.8 0.0 1.5e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 KII64629.1 - 2.4e-06 26.7 0.0 2.5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KII64629.1 - 7.9e-06 26.6 0.0 1.2e-05 26.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII64629.1 - 2.6e-05 24.3 0.0 3.3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII64629.1 - 5.6e-05 22.8 0.0 8.8e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 KII64629.1 - 7.2e-05 22.5 0.0 0.0001 22.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 KII64629.1 - 0.0001 21.1 0.0 0.00012 20.9 0.0 1.1 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 KII64629.1 - 0.00029 20.2 0.0 0.00041 19.8 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 KII64629.1 - 0.00067 19.5 0.0 0.0009 19.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII64629.1 - 0.0012 19.1 0.0 0.0018 18.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 KII64629.1 - 0.0015 18.6 0.0 0.0021 18.2 0.0 1.3 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.16 KII64629.1 - 0.0017 17.5 0.2 0.0043 16.2 0.0 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 KII64629.1 - 0.0018 17.4 0.0 0.0024 17.0 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_3 PF07726.6 KII64629.1 - 0.0022 17.5 0.0 0.003 17.1 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 KII64629.1 - 0.0024 17.7 0.0 0.0033 17.2 0.0 1.3 1 0 0 1 1 1 1 Shikimate kinase AAA_28 PF13521.1 KII64629.1 - 0.0031 17.4 0.0 0.004 17.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KII64629.1 - 0.0098 15.4 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 KII64629.1 - 0.013 14.7 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.10 KII64629.1 - 0.014 15.2 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Sigma54_activat PF00158.21 KII64629.1 - 0.016 14.6 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.8 KII64629.1 - 0.016 14.1 0.0 0.016 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) KaiC PF06745.8 KII64629.1 - 0.018 14.1 0.1 0.02 14.0 0.0 1.4 1 1 0 1 1 1 0 KaiC NACHT PF05729.7 KII64629.1 - 0.018 14.6 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 NACHT domain UPF0079 PF02367.12 KII64629.1 - 0.019 14.6 0.0 0.023 14.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_25 PF13481.1 KII64629.1 - 0.024 14.0 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 KII64629.1 - 0.026 13.5 0.0 0.028 13.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 KII64629.1 - 0.055 13.0 0.0 0.061 12.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.12 KII64629.1 - 0.069 12.5 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase Arch_ATPase PF01637.13 KII64629.1 - 0.071 12.7 0.0 0.091 12.4 0.0 1.3 1 1 0 1 1 1 0 Archaeal ATPase Parvo_NS1 PF01057.12 KII64629.1 - 0.072 11.9 0.0 0.097 11.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.1 KII64629.1 - 0.1 12.1 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 KII64629.1 - 0.14 10.9 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain AAA PF00004.24 KII64630.1 - 5e-16 59.1 0.1 7.6e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TUDOR PF00567.19 KII64631.1 - 4.3e-14 52.4 1.4 2.9e-07 30.3 0.0 3.6 3 0 0 3 3 3 2 Tudor domain CS PF04969.11 KII64631.1 - 5.3e-10 39.6 0.5 5.3e-10 39.6 0.4 2.6 3 0 0 3 3 3 1 CS domain DEAD PF00270.24 KII64631.1 - 0.011 15.2 0.0 0.027 13.9 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase PDZ PF00595.19 KII64634.1 - 0.00035 20.7 0.0 0.00057 20.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ PF00595.19 KII64635.1 - 1.9e-05 24.7 0.0 9.9e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII64635.1 - 3.9e-05 23.4 0.0 6.8e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain YwqJ-deaminase PF14431.1 KII64635.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.4 1 1 0 1 1 1 0 YwqJ-like deaminase E1_DerP2_DerF2 PF02221.10 KII64637.1 - 0.00065 19.9 0.0 0.00073 19.7 0.0 1.1 1 0 0 1 1 1 1 ML domain Zip PF02535.17 KII64638.1 - 5.3e-41 140.6 2.8 7.6e-41 140.1 1.9 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter MtrB PF05440.7 KII64638.1 - 0.068 13.2 0.1 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF1129 PF06570.6 KII64638.1 - 0.086 12.1 2.7 0.16 11.2 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Pkinase PF00069.20 KII64640.1 - 4.4e-74 248.9 0.0 6.5e-74 248.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII64640.1 - 1.3e-34 119.4 0.0 2.1e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CaMKII_AD PF08332.5 KII64640.1 - 2.1e-27 95.5 0.0 4.7e-27 94.4 0.0 1.6 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II Association DUF4440 PF14534.1 KII64640.1 - 0.0001 22.4 0.0 0.00019 21.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Kinase-like PF14531.1 KII64640.1 - 0.0015 17.5 0.0 0.0027 16.6 0.0 1.6 1 0 0 1 1 1 1 Kinase-like SnoaL_3 PF13474.1 KII64640.1 - 0.0019 18.2 0.0 0.0079 16.2 0.0 2.0 2 1 0 2 2 2 1 SnoaL-like domain Kdo PF06293.9 KII64640.1 - 0.011 14.8 0.0 0.036 13.1 0.0 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 KII64640.1 - 0.022 14.0 0.4 0.055 12.7 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL DUF3804 PF12707.2 KII64640.1 - 0.099 12.2 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3804) Fra10Ac1 PF09725.4 KII64642.1 - 3.4e-49 165.8 3.2 3.4e-49 165.8 2.2 2.3 2 1 0 2 2 2 1 Folate-sensitive fragile site protein Fra10Ac1 NdhM PF10664.4 KII64642.1 - 0.12 12.2 1.3 0.31 10.9 0.1 2.1 2 0 0 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M Ebola_NP PF05505.7 KII64642.1 - 0.99 7.3 7.4 0.8 7.6 1.0 2.1 2 0 0 2 2 2 0 Ebola nucleoprotein DUF999 PF06198.6 KII64642.1 - 6.1 6.6 9.7 1.1 8.9 0.1 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF999) FCH PF00611.18 KII64644.1 - 0.0041 17.2 2.0 0.0058 16.7 1.4 1.5 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain ScpA_ScpB PF02616.9 KII64644.1 - 0.16 11.5 1.2 0.15 11.6 0.9 1.2 1 0 0 1 1 1 0 ScpA/B protein Gal-3-0_sulfotr PF06990.6 KII64645.1 - 8.5e-23 80.6 4.3 1.4e-21 76.6 3.0 1.9 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Ldl_recept_a PF00057.13 KII64646.1 - 6.5e-07 29.1 13.0 6.5e-07 29.1 9.0 3.7 4 0 0 4 4 4 1 Low-density lipoprotein receptor domain class A Peptidase_M9_N PF08453.5 KII64647.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M9 N-terminal SNAP PF14938.1 KII64648.1 - 6e-17 61.6 0.2 8.4e-17 61.2 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII64648.1 - 0.0022 17.7 2.8 0.37 10.8 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 KII64648.1 - 0.0054 16.3 2.4 0.3 10.7 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat HTH_29 PF13551.1 KII64650.1 - 0.0005 20.1 0.0 0.00058 19.9 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 KII64650.1 - 0.013 15.2 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 'Paired box' domain HTH_11 PF08279.7 KII64650.1 - 0.028 14.0 0.1 0.23 11.1 0.0 2.0 2 0 0 2 2 2 0 HTH domain HTH_38 PF13936.1 KII64650.1 - 0.034 13.7 0.0 2.4 7.7 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Bcl-2 PF00452.14 KII64651.1 - 0.14 12.2 1.5 1.2 9.2 0.0 3.2 4 1 0 4 4 4 0 Apoptosis regulator proteins, Bcl-2 family DDE_Tnp_IS1595 PF12762.2 KII64652.1 - 1.6e-22 79.9 0.0 7.7e-22 77.7 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain MULE PF10551.4 KII64653.1 - 0.0048 17.0 0.1 0.0079 16.3 0.1 1.4 1 0 0 1 1 1 1 MULE transposase domain DDE_3 PF13358.1 KII64654.1 - 0.097 12.4 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Phage_integrase PF00589.17 KII64655.1 - 1.3e-31 109.5 0.2 2.9e-31 108.4 0.0 1.7 2 0 0 2 2 2 1 Phage integrase family Phage_int_SAM_1 PF02899.12 KII64655.1 - 0.025 14.7 0.0 0.073 13.2 0.0 1.8 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.1 KII64655.1 - 0.097 13.0 0.0 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain HTH_3 PF01381.17 KII64656.1 - 1.2e-08 34.6 0.0 1.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.2 KII64656.1 - 1.3e-06 28.3 0.0 1.7e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 KII64656.1 - 3.1e-05 24.0 0.0 4.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MerR PF00376.18 KII64656.1 - 0.014 14.9 0.2 0.028 13.9 0.0 1.6 2 0 0 2 2 2 0 MerR family regulatory protein MerR_1 PF13411.1 KII64656.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 MerR HTH family regulatory protein RNase_T PF00929.19 KII64658.1 - 0.0065 16.7 0.0 0.11 12.7 0.0 2.3 1 1 0 1 1 1 1 Exonuclease Mac-1 PF09028.5 KII64658.1 - 0.11 11.2 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Mac 1 PAPS_reduct PF01507.14 KII64659.1 - 7.8e-52 175.5 0.0 9.8e-52 175.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family IPPT PF01715.12 KII64659.1 - 0.015 14.3 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 IPP transferase DDE_Tnp_1 PF01609.16 KII64659.1 - 0.048 13.1 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Transposase DDE domain Phage_lysozyme PF00959.14 KII64660.1 - 0.027 14.7 0.3 7.3 6.9 0.0 2.7 3 0 0 3 3 3 0 Phage lysozyme DUF2806 PF10987.3 KII64661.1 - 9.9e-05 21.9 0.8 0.00015 21.3 0.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2806) ThylakoidFormat PF11264.3 KII64661.1 - 0.064 12.8 0.4 0.095 12.3 0.3 1.3 1 0 0 1 1 1 0 Thylakoid formation protein bZIP_2 PF07716.10 KII64663.1 - 0.038 13.8 12.6 0.066 13.0 8.7 1.4 1 0 0 1 1 1 0 Basic region leucine zipper DUF1509 PF07420.6 KII64663.1 - 5.7 6.0 16.7 0.61 9.2 6.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1509) rve PF00665.21 KII64665.1 - 2.2e-26 92.3 0.1 1.2e-25 89.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII64665.1 - 3e-24 85.5 0.0 5.8e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII64665.1 - 1.5e-07 31.2 0.0 3.5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII64665.1 - 0.00015 21.2 0.0 0.0004 19.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.1 KII64665.1 - 0.013 15.9 0.0 0.039 14.4 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease AT_hook PF02178.14 KII64667.1 - 0.00075 18.8 2.8 0.0024 17.3 1.9 1.9 1 0 0 1 1 1 1 AT hook motif Bul1_N PF04425.7 KII64668.1 - 0.11 11.0 4.2 0.14 10.7 2.9 1.1 1 0 0 1 1 1 0 Bul1 N terminus MukE PF04288.8 KII64669.1 - 0.0071 15.1 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 MukE-like family DDE_3 PF13358.1 KII64670.1 - 2e-19 69.8 0.1 2.6e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII64670.1 - 1.1e-05 25.4 0.0 1.5e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain LolA PF03548.10 KII64670.1 - 0.02 14.5 0.0 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA Adap_comp_sub PF00928.16 KII64670.1 - 0.078 12.0 0.4 0.099 11.7 0.3 1.1 1 0 0 1 1 1 0 Adaptor complexes medium subunit family DDE_1 PF03184.14 KII64670.1 - 0.084 12.0 0.0 0.095 11.8 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease AT_hook PF02178.14 KII64671.1 - 0.06 13.0 3.1 0.15 11.8 2.2 1.7 1 0 0 1 1 1 0 AT hook motif Rer1 PF03248.8 KII64672.1 - 0.049 13.2 0.1 0.071 12.6 0.1 1.3 1 0 0 1 1 1 0 Rer1 family Shisa PF13908.1 KII64675.1 - 0.67 10.1 2.8 0.36 10.9 0.5 1.5 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator TIM PF00121.13 KII64677.1 - 2.7e-10 39.7 0.0 3.5e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase Kri1_C PF12936.2 KII64678.1 - 4.2e-21 74.7 0.1 4.2e-21 74.7 0.1 2.8 4 0 0 4 4 4 1 KRI1-like family C-terminal RVT_1 PF00078.22 KII64681.1 - 1.4e-09 37.6 0.0 2.2e-09 36.9 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CCDC32 PF14989.1 KII64683.1 - 0.0063 16.3 0.3 0.012 15.4 0.2 1.4 1 0 0 1 1 1 1 Coiled-coil domain containing 32 RRF PF01765.14 KII64683.1 - 0.028 13.8 1.5 5.6 6.4 0.0 2.1 2 0 0 2 2 2 0 Ribosome recycling factor Tcell_CD4_Cterm PF12104.3 KII64683.1 - 0.1 12.1 0.5 0.24 10.9 0.3 1.5 1 0 0 1 1 1 0 T cell CD4 receptor C terminal region Molybdopterin PF00384.17 KII64683.1 - 0.15 10.7 0.0 0.17 10.6 0.0 1.0 1 0 0 1 1 1 0 Molybdopterin oxidoreductase DDE_3 PF13358.1 KII64684.1 - 2e-10 40.5 0.0 2.8e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease MFS_1 PF07690.11 KII64685.1 - 6.3e-11 41.5 22.4 4.6e-07 28.8 6.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KII64685.1 - 0.00011 20.7 11.3 0.0021 16.5 7.2 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein DUF1129 PF06570.6 KII64685.1 - 0.89 8.8 5.4 0.83 8.9 0.2 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1129) HTH_29 PF13551.1 KII64686.1 - 0.0004 20.5 0.1 0.00064 19.8 0.0 1.3 1 1 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII64686.1 - 0.001 19.0 0.7 0.0021 18.1 0.5 1.6 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.1 KII64686.1 - 0.0013 18.3 0.1 0.02 14.5 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain Arg_repressor PF01316.16 KII64686.1 - 0.0019 17.6 0.5 0.0019 17.6 0.3 2.0 2 0 0 2 2 2 1 Arginine repressor, DNA binding domain HTH_38 PF13936.1 KII64686.1 - 0.012 15.2 2.1 3.2 7.3 0.3 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.1 KII64686.1 - 0.012 15.5 0.0 0.039 13.9 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_7 PF02796.10 KII64686.1 - 0.021 14.6 0.1 0.051 13.4 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase YflT PF11181.3 KII64686.1 - 0.16 12.1 1.8 0.2 11.7 0.6 1.7 2 0 0 2 2 2 0 Heat induced stress protein YflT HTH_23 PF13384.1 KII64687.1 - 9.8e-05 21.8 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.1 KII64687.1 - 0.00054 19.2 0.0 0.00096 18.4 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 KII64687.1 - 0.00062 19.3 0.0 0.00091 18.8 0.0 1.2 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 KII64687.1 - 0.0015 18.2 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB CENP-B_N PF04218.8 KII64687.1 - 0.0016 17.7 0.0 0.0027 17.0 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.1 KII64687.1 - 0.019 14.9 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Fe_dep_repress PF01325.14 KII64687.1 - 0.02 14.7 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Sigma70_r4_2 PF08281.7 KII64687.1 - 0.035 13.5 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 Sigma70_r4 PF04545.11 KII64687.1 - 0.061 12.6 0.0 0.095 12.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 PAX PF00292.13 KII64687.1 - 0.065 12.9 0.0 0.075 12.7 0.0 1.1 1 0 0 1 1 1 0 'Paired box' domain ComX PF05952.7 KII64687.1 - 0.084 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacillus competence pheromone ComX HTH_1 PF00126.22 KII64687.1 - 0.089 12.5 0.2 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Ribosomal_L13e PF01294.13 KII64688.1 - 2.3e-66 222.6 4.4 3e-66 222.2 3.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e DDE_1 PF03184.14 KII64689.1 - 3e-12 46.1 0.6 5.3e-12 45.3 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease WD40 PF00400.27 KII64692.1 - 6e-56 184.4 24.8 4e-10 39.1 0.1 9.8 10 0 0 10 10 10 7 WD domain, G-beta repeat Utp12 PF04003.7 KII64692.1 - 2.1e-15 56.5 0.7 5.9e-15 55.1 0.5 1.8 1 0 0 1 1 1 1 Dip2/Utp12 Family Utp21 PF04192.7 KII64692.1 - 0.022 13.8 0.4 0.05 12.7 0.1 1.7 2 0 0 2 2 2 0 Utp21 specific WD40 associated putative domain Ribosomal_L11_N PF03946.9 KII64693.1 - 5.7e-15 54.5 0.1 1.4e-14 53.2 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 KII64693.1 - 5e-14 52.2 0.0 8.3e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain DDE_3 PF13358.1 KII64694.1 - 4.6e-05 23.2 0.0 6.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease NAD_binding_8 PF13450.1 KII64694.1 - 0.09 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain RA PF00788.18 KII64695.1 - 1.6e-10 41.2 0.2 4.1e-10 39.9 0.1 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DIL PF01843.14 KII64695.1 - 1.2e-05 25.1 3.7 1.9e-05 24.4 0.5 2.7 2 0 0 2 2 2 1 DIL domain RA PF00788.18 KII64696.1 - 6.1e-07 29.8 0.0 9.2e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain HNF-1A_C PF04813.7 KII64698.1 - 0.18 12.0 1.2 0.32 11.2 0.8 1.4 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus Chitin_bind_1 PF00187.14 KII64699.1 - 0.18 11.8 0.8 0.31 11.0 0.6 1.4 1 1 0 1 1 1 0 Chitin recognition protein EphA2_TM PF14575.1 KII64700.1 - 0.00018 21.8 0.1 0.00034 20.9 0.1 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TRP PF06011.7 KII64700.1 - 0.0049 15.4 0.5 0.0064 15.1 0.3 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TMEM154 PF15102.1 KII64700.1 - 0.012 15.3 1.6 0.024 14.3 1.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family Orthoreo_P10 PF07204.6 KII64700.1 - 0.024 14.3 0.5 0.046 13.4 0.3 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Shisa PF13908.1 KII64700.1 - 0.031 14.4 0.1 0.044 13.9 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ODV-E18 PF10717.4 KII64700.1 - 0.035 13.5 0.7 0.035 13.5 0.5 2.0 3 0 0 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 Protocadherin PF08374.6 KII64700.1 - 0.045 13.3 0.8 0.072 12.7 0.5 1.3 1 0 0 1 1 1 0 Protocadherin LRRC37AB_C PF14914.1 KII64700.1 - 0.053 12.9 0.8 0.097 12.0 0.6 1.5 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Rifin_STEVOR PF02009.11 KII64700.1 - 0.13 11.8 4.3 0.21 11.2 3.0 1.4 1 0 0 1 1 1 0 Rifin/stevor family ASFV_J13L PF05568.6 KII64700.1 - 0.41 10.1 1.9 0.65 9.5 1.3 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein Synaptobrevin PF00957.16 KII64700.1 - 1.6 8.3 6.3 3.5 7.2 4.3 1.6 1 0 0 1 1 1 0 Synaptobrevin HEAT PF02985.17 KII64702.1 - 1.2e-06 28.0 0.1 0.013 15.5 0.0 4.1 5 0 0 5 5 5 2 HEAT repeat Pkinase PF00069.20 KII64702.1 - 3e-05 23.2 0.3 8.6e-05 21.8 0.2 1.7 1 0 0 1 1 1 1 Protein kinase domain CLASP_N PF12348.3 KII64702.1 - 0.00066 19.0 0.3 0.66 9.2 0.0 3.1 2 1 1 3 3 3 2 CLASP N terminal Pkinase_Tyr PF07714.12 KII64702.1 - 0.001 18.2 0.1 0.002 17.2 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Cohesin_HEAT PF12765.2 KII64702.1 - 0.0036 17.2 0.1 0.0096 15.8 0.0 1.8 1 0 0 1 1 1 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.1 KII64702.1 - 0.015 15.5 0.0 0.26 11.5 0.0 2.7 3 1 0 3 3 3 0 HEAT repeats FYVE PF01363.16 KII64704.1 - 0.00086 19.1 0.1 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 FYVE zinc finger CENP-Q PF13094.1 KII64704.1 - 0.017 15.1 14.5 0.027 14.5 10.1 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit HHA PF05321.6 KII64704.1 - 0.021 14.9 0.2 0.021 14.9 0.1 3.2 3 0 0 3 3 3 0 Haemolysin expression modulating protein Homeobox PF00046.24 KII64704.1 - 0.024 14.2 0.6 0.09 12.4 0.3 2.2 1 1 0 1 1 1 0 Homeobox domain Telomere_reg-2 PF10193.4 KII64704.1 - 0.11 12.7 2.9 0.39 11.0 0.0 2.6 2 1 0 2 2 2 0 Telomere length regulation protein Tropomyosin_1 PF12718.2 KII64704.1 - 0.64 9.8 21.8 0.18 11.6 4.7 2.9 1 1 2 3 3 3 0 Tropomyosin like Hemagglutinin PF00509.13 KII64704.1 - 1.5 6.9 7.2 2 6.4 5.0 1.2 1 0 0 1 1 1 0 Haemagglutinin DUF3347 PF11827.3 KII64704.1 - 7 6.6 11.9 4.6 7.2 6.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) RUN PF02759.14 KII64705.1 - 8.4e-05 22.3 0.0 0.00025 20.8 0.0 1.5 1 1 0 1 1 1 1 RUN domain PXA PF02194.10 KII64706.1 - 8.5e-23 80.8 4.5 8.5e-23 80.8 3.1 2.0 2 0 0 2 2 2 1 PXA domain PX PF00787.19 KII64706.1 - 2.5e-16 59.4 0.9 9.5e-16 57.6 0.6 1.9 1 0 0 1 1 1 1 PX domain Nexin_C PF08628.7 KII64706.1 - 2.3e-14 53.4 0.1 1.1e-13 51.1 0.0 2.3 2 1 1 3 3 3 1 Sorting nexin C terminal I-set PF07679.11 KII64707.1 - 1.1e-07 31.6 0.1 1.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.12 KII64707.1 - 3.3e-05 23.7 1.1 6.3e-05 22.8 0.7 1.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.1 KII64707.1 - 9.9e-05 22.3 0.2 0.00014 21.9 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.20 KII64707.1 - 0.00028 20.9 0.5 0.0013 18.8 0.4 1.9 1 1 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.6 KII64707.1 - 0.034 13.9 1.0 0.053 13.2 0.7 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Receptor_2B4 PF11465.3 KII64707.1 - 0.041 13.7 0.1 0.058 13.3 0.1 1.3 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 Thaumatin PF00314.12 KII64707.1 - 0.074 12.4 0.2 0.09 12.2 0.1 1.1 1 0 0 1 1 1 0 Thaumatin family CBM_15 PF03426.9 KII64708.1 - 0.048 13.0 0.1 7.7 5.8 0.0 2.1 2 0 0 2 2 2 0 Carbohydrate binding domain (family 15) Prok-E2_C PF14459.1 KII64708.1 - 0.062 13.3 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family C I-set PF07679.11 KII64708.1 - 0.067 13.0 0.0 0.097 12.5 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain Golgin_A5 PF09787.4 KII64709.1 - 0.00033 19.3 3.8 0.00043 18.9 1.8 1.9 1 1 0 1 1 1 1 Golgin subfamily A member 5 Vps16_C PF04840.7 KII64709.1 - 0.071 12.0 7.7 0.31 9.9 5.4 2.0 1 1 0 1 1 1 0 Vps16, C-terminal region CENP-B_N PF04218.8 KII64710.1 - 8.1e-05 21.9 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain LacI PF00356.16 KII64710.1 - 0.0031 17.0 0.0 0.006 16.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family DUF977 PF06163.6 KII64710.1 - 0.0032 17.1 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF977) HTH_IclR PF09339.5 KII64710.1 - 0.0064 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_3 PF01381.17 KII64710.1 - 0.024 14.4 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix HTH_psq PF05225.11 KII64710.1 - 0.031 13.8 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_10 PF04967.7 KII64710.1 - 0.048 13.2 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 HTH DNA binding domain Phage_CI_repr PF07022.8 KII64710.1 - 0.058 13.4 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain HTH_Crp_2 PF13545.1 KII64710.1 - 0.066 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_24 PF13412.1 KII64710.1 - 0.069 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_23 PF13384.1 KII64710.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DnaJ PF00226.26 KII64711.1 - 3.6e-23 81.0 0.1 9.3e-23 79.7 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_2 PF12756.2 KII64711.1 - 7.8e-08 32.3 4.7 0.0018 18.3 0.9 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 KII64711.1 - 5.3e-05 23.2 8.0 0.00028 20.9 1.2 2.8 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 KII64711.1 - 7.6e-05 22.8 7.2 0.037 14.3 1.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 KII64711.1 - 0.00013 21.7 5.3 0.21 11.5 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII64711.1 - 0.014 15.5 2.2 0.014 15.5 1.6 2.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 KII64711.1 - 0.026 14.8 7.7 0.79 10.2 0.8 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger RPM2 PF08579.6 KII64711.1 - 0.041 14.0 0.2 0.16 12.1 0.2 2.1 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) zf-DBF PF07535.7 KII64711.1 - 0.49 10.1 4.6 0.44 10.2 0.8 2.3 2 0 0 2 2 2 0 DBF zinc finger Es2 PF09751.4 KII64712.1 - 6.9e-59 200.3 8.1 1.9e-41 142.8 0.7 2.1 1 1 1 2 2 2 2 Nuclear protein Es2 DUF4371 PF14291.1 KII64713.1 - 5e-09 36.0 2.8 1.4e-08 34.5 1.8 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4371) Vps4_C PF09336.5 KII64714.1 - 3.1e-08 33.3 0.0 5.3e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA PF00004.24 KII64714.1 - 2.1e-07 31.2 1.0 2.6e-05 24.4 0.0 2.5 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) MHCassoc_trimer PF08831.5 KII64714.1 - 0.0054 16.5 0.1 0.0095 15.7 0.0 1.3 1 0 0 1 1 1 1 Class II MHC-associated invariant chain trimerisation domain Sec1 PF00995.18 KII64715.1 - 6.1e-36 124.1 1.2 7.3e-36 123.9 0.8 1.0 1 0 0 1 1 1 1 Sec1 family DUF1741 PF08427.5 KII64715.1 - 0.018 14.4 0.6 0.038 13.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1741) Sec1 PF00995.18 KII64716.1 - 5.1e-31 107.9 1.4 6e-31 107.7 1.0 1.1 1 0 0 1 1 1 1 Sec1 family Kri1 PF05178.7 KII64717.1 - 0.017 15.3 0.9 0.031 14.5 0.6 1.6 1 1 0 1 1 1 0 KRI1-like family SH3_1 PF00018.23 KII64717.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 SH3 domain LIM PF00412.17 KII64718.1 - 0.00013 22.0 3.9 0.00038 20.4 2.7 1.7 1 1 0 1 1 1 1 LIM domain zf-Di19 PF05605.7 KII64718.1 - 0.15 12.1 1.0 0.31 11.1 0.7 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_1 PF14446.1 KII64718.1 - 0.22 11.2 3.0 1.4 8.7 2.1 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.1 KII64718.1 - 1.1 9.1 5.1 21 5.0 3.2 2.4 1 1 1 2 2 2 0 Ring finger domain Clusterin PF01093.12 KII64721.1 - 0.0036 16.1 1.0 0.0053 15.6 0.5 1.4 1 1 0 1 1 1 1 Clusterin IL6 PF00489.12 KII64721.1 - 0.005 16.4 0.7 0.009 15.6 0.3 1.4 1 1 0 1 1 1 1 Interleukin-6/G-CSF/MGF family DUF848 PF05852.6 KII64721.1 - 0.0065 16.3 3.0 0.01 15.6 2.1 1.5 1 1 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) LMP PF04778.7 KII64721.1 - 0.0096 15.6 3.5 0.019 14.7 2.4 1.6 1 0 0 1 1 1 1 LMP repeated region Glyco_hydro_1 PF00232.13 KII64721.1 - 0.025 12.7 1.5 0.029 12.5 1.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 YjcZ PF13990.1 KII64721.1 - 0.04 13.0 0.2 0.05 12.7 0.1 1.1 1 0 0 1 1 1 0 YjcZ-like protein Baculo_PEP_C PF04513.7 KII64721.1 - 0.06 13.1 1.3 0.1 12.3 0.9 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 KII64721.1 - 0.062 13.1 2.7 0.12 12.2 1.5 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) CitX PF03802.9 KII64721.1 - 0.081 12.3 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase LOH1CR12 PF10158.4 KII64721.1 - 0.091 12.5 1.0 0.15 11.8 0.7 1.4 1 0 0 1 1 1 0 Tumour suppressor protein DUF2408 PF10303.4 KII64721.1 - 0.098 12.7 5.0 0.041 13.9 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) Cep57_MT_bd PF06657.8 KII64721.1 - 0.14 12.1 5.6 0.47 10.4 1.6 2.5 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Cortex-I_coil PF09304.5 KII64721.1 - 0.19 11.8 6.2 0.27 11.2 2.9 1.9 2 0 0 2 2 2 0 Cortexillin I, coiled coil DUF2570 PF10828.3 KII64721.1 - 0.19 11.3 2.1 0.28 10.8 1.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) Prefoldin PF02996.12 KII64721.1 - 0.2 11.3 8.1 6.8 6.3 1.0 3.1 2 1 1 3 3 3 0 Prefoldin subunit TMPIT PF07851.8 KII64721.1 - 0.25 10.3 3.2 0.27 10.2 2.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein ALMT PF11744.3 KII64721.1 - 0.71 8.4 4.1 1.1 7.8 2.8 1.3 1 1 0 1 1 1 0 Aluminium activated malate transporter Z1 PF10593.4 KII64721.1 - 0.72 9.0 3.7 1 8.5 2.5 1.3 1 1 0 1 1 1 0 Z1 domain DUF1664 PF07889.7 KII64721.1 - 2.9 7.6 6.7 1 9.1 2.8 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Med28 PF11594.3 KII64721.1 - 4.4 7.5 7.8 2.6 8.3 3.6 2.0 1 1 1 2 2 2 0 Mediator complex subunit 28 KH_5 PF13184.1 KII64721.1 - 6.1 6.7 6.8 38 4.1 2.5 2.8 2 1 0 2 2 2 0 NusA-like KH domain DDE_Tnp_IS1595 PF12762.2 KII64722.1 - 9.3e-15 54.7 0.1 6.1e-14 52.1 0.1 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain Zn_ribbon_recom PF13408.1 KII64722.1 - 0.083 13.1 3.3 0.2 11.9 2.3 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-CHY PF05495.7 KII64722.1 - 0.12 12.5 4.2 0.31 11.2 2.9 1.7 1 0 0 1 1 1 0 CHY zinc finger CTP_transf_2 PF01467.21 KII64726.1 - 1.7e-20 73.6 0.0 6.3e-17 62.0 0.0 2.1 2 0 0 2 2 2 2 Cytidylyltransferase Dimer_Tnp_hAT PF05699.9 KII64728.1 - 1.5e-15 56.5 0.3 2.9e-15 55.6 0.2 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ldl_recept_a PF00057.13 KII64731.1 - 1.4e-11 44.0 30.0 8.5e-06 25.5 7.5 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Retrotrans_gag PF03732.12 KII64734.1 - 1.8e-05 24.7 0.0 4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.18 KII64734.1 - 0.00036 20.3 3.4 0.00036 20.3 2.4 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.1 KII64734.1 - 0.0024 17.5 0.1 0.0052 16.4 0.1 1.6 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.15 KII64734.1 - 0.018 14.9 0.0 0.044 13.7 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII64734.1 - 0.057 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.1 KII64734.1 - 0.075 12.5 2.0 0.21 11.0 1.4 1.8 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger GATA PF00320.22 KII64739.1 - 9e-14 50.5 3.0 9e-14 50.5 2.1 2.1 2 0 0 2 2 2 1 GATA zinc finger zf-TFIIB PF13453.1 KII64739.1 - 0.001 18.1 1.0 0.001 18.1 0.7 2.0 2 0 0 2 2 2 1 Transcription factor zinc-finger DUF2709 PF10915.3 KII64739.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2709) Ribosomal_L37ae PF01780.14 KII64739.1 - 0.84 9.5 9.5 0.29 11.0 0.5 2.7 1 1 1 2 2 2 0 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.2 KII64739.1 - 1.2 9.0 13.8 4 7.3 1.8 2.6 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DZR PF12773.2 KII64739.1 - 1.4 8.8 12.7 32 4.4 1.3 2.9 1 1 1 2 2 2 0 Double zinc ribbon XPA_N PF01286.13 KII64739.1 - 1.9 8.2 8.9 0.078 12.6 1.4 2.1 3 0 0 3 3 3 0 XPA protein N-terminal C1_1 PF00130.17 KII64739.1 - 3.2 7.5 8.8 2.3 7.9 1.4 2.7 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) eIF-5_eIF-2B PF01873.12 KII64739.1 - 5.3 6.7 9.2 4.7 6.8 1.9 2.6 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Zn-ribbon_8 PF09723.5 KII64739.1 - 5.6 7.0 11.8 0.5 10.3 0.1 3.5 4 0 0 4 4 4 0 Zinc ribbon domain Prok-RING_1 PF14446.1 KII64739.1 - 6.2 6.6 9.3 2.3 8.0 0.8 3.0 2 2 1 3 3 3 0 Prokaryotic RING finger family 1 DDE_3 PF13358.1 KII64740.1 - 0.00022 20.9 0.0 0.00037 20.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease EcoR124_C PF12008.3 KII64740.1 - 0.04 13.1 0.0 0.045 12.9 0.0 1.1 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal YdjO PF14169.1 KII64741.1 - 0.11 11.9 0.0 0.39 10.2 0.0 2.0 1 1 0 1 1 1 0 Cold-inducible protein YdjO zf-TFIIB PF13453.1 KII64742.1 - 0.0058 15.7 0.2 0.0092 15.1 0.2 1.3 1 0 0 1 1 1 1 Transcription factor zinc-finger DUF2296 PF10058.4 KII64742.1 - 0.098 12.4 3.1 0.22 11.2 2.1 1.6 1 0 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) DDE_Tnp_IS1595 PF12762.2 KII64743.1 - 3.5e-25 88.6 0.0 4.4e-25 88.2 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII64743.1 - 0.13 11.4 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family RVP PF00077.15 KII64744.1 - 6.3e-08 32.4 0.6 2.3e-07 30.6 0.1 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Retrotrans_gag PF03732.12 KII64744.1 - 5e-05 23.2 0.1 0.00012 22.0 0.1 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.18 KII64744.1 - 7.8e-05 22.4 2.7 0.00013 21.6 1.9 1.4 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII64744.1 - 0.00017 21.9 0.1 0.00042 20.7 0.0 1.7 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII64744.1 - 0.00021 21.0 0.0 0.00046 19.9 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII64744.1 - 0.00073 19.0 0.2 0.002 17.6 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2E PF12382.3 KII64744.1 - 0.0016 18.2 0.0 0.0029 17.3 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon peptidase zf-CCHC_4 PF14392.1 KII64744.1 - 0.04 13.5 0.2 0.083 12.5 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle HR1 PF02185.11 KII64744.1 - 0.048 13.4 0.8 0.048 13.4 0.6 2.2 2 0 0 2 2 2 0 Hr1 repeat zf-CCHC_2 PF13696.1 KII64744.1 - 0.073 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Zinc knuckle DUF1759 PF03564.10 KII64744.1 - 0.12 12.1 1.0 0.35 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) SlyX PF04102.7 KII64744.1 - 0.19 12.1 0.3 0.19 12.1 0.2 2.3 2 0 0 2 2 2 0 SlyX zf-CCHC_5 PF14787.1 KII64744.1 - 0.26 10.8 2.2 0.47 9.9 1.5 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger TMF_DNA_bd PF12329.3 KII64744.1 - 5.5 6.8 8.3 0.43 10.4 1.4 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding PSP PF04046.11 KII64745.1 - 3.1e-16 58.5 0.1 5e-16 57.8 0.1 1.4 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.18 KII64745.1 - 0.00032 20.4 1.3 0.00055 19.7 0.9 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 KII64745.1 - 0.019 14.6 0.1 0.04 13.5 0.1 1.6 1 0 0 1 1 1 0 Zinc knuckle OrfB_Zn_ribbon PF07282.6 KII64745.1 - 0.062 12.9 0.4 0.12 12.0 0.2 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Bromodomain PF00439.20 KII64746.1 - 1.3e-42 143.5 1.6 4.2e-21 74.6 0.0 3.0 3 0 0 3 3 3 2 Bromodomain DUF2262 PF10020.4 KII64746.1 - 0.078 13.1 0.3 0.33 11.1 0.2 2.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) DDE_3 PF13358.1 KII64747.1 - 1.5e-28 99.3 0.0 2.4e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_IS630 PF01710.11 KII64747.1 - 3.3e-05 23.5 0.5 6e-05 22.7 0.4 1.4 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.1 KII64747.1 - 0.00025 20.5 0.0 0.0029 17.2 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain rve PF00665.21 KII64747.1 - 0.0022 18.0 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HTH_38 PF13936.1 KII64747.1 - 0.012 15.1 1.6 5.2 6.7 0.0 2.9 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.1 KII64747.1 - 0.017 15.0 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII64747.1 - 0.021 14.8 0.5 0.048 13.7 0.1 1.8 2 0 0 2 2 2 0 Transposase GerE PF00196.14 KII64747.1 - 0.026 13.8 1.6 0.16 11.2 0.1 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_7 PF02796.10 KII64747.1 - 0.043 13.6 0.6 0.22 11.4 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_11 PF08279.7 KII64747.1 - 0.048 13.3 0.3 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 HTH domain DDE_Tnp_ISAZ013 PF07592.6 KII64747.1 - 0.051 12.3 0.1 6.8 5.3 0.0 2.2 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain DDE_3 PF13358.1 KII64748.1 - 0.064 12.9 0.0 0.083 12.6 0.0 1.2 1 1 0 1 1 1 0 DDE superfamily endonuclease Myb_DNA-bind_5 PF13873.1 KII64749.1 - 9.9e-10 38.1 2.9 2e-09 37.2 2.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KII64749.1 - 0.0065 16.5 1.1 0.012 15.7 0.7 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KII64749.1 - 0.0078 16.2 0.4 0.021 14.8 0.1 1.9 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 KII64749.1 - 0.057 14.0 2.3 0.09 13.4 1.6 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DDE_3 PF13358.1 KII64750.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 1 0 1 1 1 0 DDE superfamily endonuclease Galactosyl_T PF01762.16 KII64751.1 - 1.7e-29 102.8 0.8 2.3e-29 102.3 0.6 1.1 1 0 0 1 1 1 1 Galactosyltransferase XFP PF03894.10 KII64754.1 - 0.021 14.4 0.0 0.025 14.1 0.0 1.1 1 0 0 1 1 1 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Rota_NSP3 PF01665.11 KII64756.1 - 0.09 11.7 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Rotavirus non-structural protein NSP3 DDE_3 PF13358.1 KII64758.1 - 0.0017 18.1 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Sensor_TM1 PF13755.1 KII64759.1 - 0.14 11.6 0.0 0.67 9.5 0.0 1.9 2 0 0 2 2 2 0 Sensor N-terminal transmembrane domain DNase_NucA_NucB PF14040.1 KII64761.1 - 1e-08 35.2 26.3 40 4.4 0.0 10.7 10 0 0 10 10 10 10 Deoxyribonuclease NucA/NucB AKAP28 PF14469.1 KII64761.1 - 0.059 12.9 4.9 55 3.3 0.0 7.1 10 0 0 10 10 10 0 28 kDa A-kinase anchor SET PF00856.23 KII64767.1 - 0.0011 19.3 1.2 0.0058 16.9 0.8 2.2 1 1 0 1 1 1 1 SET domain Ldl_recept_a PF00057.13 KII64772.1 - 7.8e-08 32.0 13.7 7.8e-08 32.0 9.5 2.5 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A SH3_6 PF12913.2 KII64773.1 - 0.0034 16.5 0.2 0.0055 15.9 0.1 1.4 1 0 0 1 1 1 1 SH3 domain of the SH3b1 type Asp_protease_2 PF13650.1 KII64775.1 - 3.7e-10 40.1 0.0 9.7e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII64775.1 - 2.8e-09 36.6 0.0 6.5e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII64775.1 - 4e-07 29.8 0.1 1.2e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII64775.1 - 3.9e-06 26.4 0.2 1.3e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.6 KII64775.1 - 0.0037 17.1 0.5 0.015 15.1 0.0 2.0 2 0 0 2 2 2 1 Retroviral aspartyl protease Prefoldin PF02996.12 KII64775.1 - 2.4 7.8 6.4 10 5.7 0.1 2.6 2 0 0 2 2 2 0 Prefoldin subunit Rpr2 PF04032.11 KII64778.1 - 0.13 12.1 1.0 2.5 8.0 0.7 2.3 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Matrilin_ccoil PF10393.4 KII64778.1 - 0.24 10.7 0.9 3.4 7.1 0.6 2.2 1 1 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin NHL PF01436.16 KII64780.1 - 1.1e-18 66.1 0.9 2e-05 24.2 0.0 5.4 6 0 0 6 6 6 3 NHL repeat Filamin PF00630.14 KII64780.1 - 4.3e-14 52.9 0.0 1.4e-13 51.2 0.0 1.9 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-C3HC4_4 PF15227.1 KII64780.1 - 1.6e-11 43.8 9.7 1.6e-11 43.8 6.7 2.9 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.19 KII64780.1 - 3.3e-09 36.4 6.5 3.3e-09 36.4 4.5 3.5 3 1 0 3 3 3 1 B-box zinc finger zf-C3HC4 PF00097.20 KII64780.1 - 3.7e-08 32.8 9.4 3.7e-08 32.8 6.5 2.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KII64780.1 - 5.1e-08 32.6 10.0 5.1e-08 32.6 6.9 2.6 3 0 0 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.1 KII64780.1 - 6.6e-08 32.1 3.5 6.6e-08 32.1 2.4 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.1 KII64780.1 - 2.6e-07 30.5 10.7 2.6e-07 30.5 7.4 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KII64780.1 - 1.7e-06 27.5 8.8 1.7e-06 27.5 6.1 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SGL PF08450.7 KII64780.1 - 0.00012 21.6 0.2 0.29 10.4 0.0 3.0 1 1 2 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region zf-RING_5 PF14634.1 KII64780.1 - 0.00014 21.4 8.9 0.00014 21.4 6.2 2.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.3 KII64780.1 - 0.67 9.5 9.1 0.2 11.1 3.7 2.1 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Ribosomal_L34 PF00468.12 KII64781.1 - 4.6e-17 61.4 4.3 4.6e-17 61.4 3.0 1.6 1 1 0 1 1 1 1 Ribosomal protein L34 DUF4041 PF13250.1 KII64783.1 - 0.63 9.6 8.0 1.2 8.7 0.1 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4041) RED_C PF07807.6 KII64784.1 - 0.049 13.8 0.0 0.088 13.0 0.0 1.3 1 0 0 1 1 1 0 RED-like protein C-terminal region zf-UBR PF02207.15 KII64787.1 - 0.16 11.6 20.0 0.39 10.4 13.8 1.7 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DUF4014 PF13198.1 KII64787.1 - 0.19 12.1 3.8 1.3 9.4 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4014) RED_C PF07807.6 KII64789.1 - 0.046 13.9 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 RED-like protein C-terminal region DUF4361 PF14274.1 KII64793.1 - 0.022 14.4 0.6 0.061 12.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4361) DUF4573 PF15140.1 KII64793.1 - 0.048 13.2 1.2 0.067 12.7 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4573) RVT_1 PF00078.22 KII64797.1 - 1e-16 60.9 0.2 1.7e-16 60.2 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ATG16 PF08614.6 KII64798.1 - 2.5e-05 24.1 10.5 0.00032 20.5 2.1 2.1 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Spc7 PF08317.6 KII64798.1 - 0.002 16.8 12.6 0.0031 16.2 3.0 2.1 2 0 0 2 2 2 1 Spc7 kinetochore protein DUF2730 PF10805.3 KII64798.1 - 0.0026 17.4 3.5 0.0075 15.9 0.4 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2730) DUF4200 PF13863.1 KII64798.1 - 0.0033 17.3 12.2 0.0082 16.0 3.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) DivIVA PF05103.8 KII64798.1 - 0.0056 16.7 11.0 0.032 14.2 2.8 2.3 2 0 0 2 2 2 1 DivIVA protein Seryl_tRNA_N PF02403.17 KII64798.1 - 0.0079 16.2 8.6 0.03 14.3 2.0 2.3 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain AAA_13 PF13166.1 KII64798.1 - 0.012 14.0 14.1 0.058 11.8 9.8 1.7 1 1 0 1 1 1 0 AAA domain COG5 PF10392.4 KII64798.1 - 0.017 15.0 3.8 0.017 15.0 2.6 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Sec8_exocyst PF04048.9 KII64798.1 - 0.023 14.3 13.2 0.035 13.7 3.7 2.3 1 1 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF972 PF06156.8 KII64798.1 - 0.023 15.0 8.5 0.023 15.0 5.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Folliculin PF11704.3 KII64798.1 - 0.028 13.9 3.0 0.039 13.5 2.1 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport NPV_P10 PF05531.7 KII64798.1 - 0.03 14.5 13.6 0.099 12.9 2.3 2.5 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.3 KII64798.1 - 0.031 11.6 10.9 0.038 11.3 7.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.7 KII64798.1 - 0.039 13.7 12.7 0.081 12.6 4.4 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4315 PF14193.1 KII64798.1 - 0.039 13.8 1.3 0.039 13.8 0.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4315) Bacillus_HBL PF05791.6 KII64798.1 - 0.041 13.2 15.0 0.016 14.6 6.7 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) APG6 PF04111.7 KII64798.1 - 0.056 12.4 16.5 0.079 11.9 9.6 1.9 1 1 1 2 2 2 0 Autophagy protein Apg6 Spc24 PF08286.6 KII64798.1 - 0.058 13.0 17.0 0.09 12.4 5.1 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 COG2 PF06148.6 KII64798.1 - 0.059 13.2 9.7 0.27 11.1 0.3 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 IncA PF04156.9 KII64798.1 - 0.06 12.9 17.7 0.25 10.9 12.3 1.7 1 1 0 1 1 1 0 IncA protein CDC37_N PF03234.9 KII64798.1 - 0.068 13.4 10.3 0.1 12.9 7.1 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding DUF1027 PF06265.6 KII64798.1 - 0.086 12.7 2.2 0.55 10.1 0.0 2.5 1 1 2 3 3 2 0 Protein of unknown function (DUF1027) DUF4201 PF13870.1 KII64798.1 - 0.097 12.0 17.1 0.054 12.9 4.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) WXG100 PF06013.7 KII64798.1 - 0.1 12.6 6.3 1.7 8.6 2.4 3.2 1 1 2 3 3 3 0 Proteins of 100 residues with WXG DivIC PF04977.10 KII64798.1 - 0.11 11.9 20.9 0.15 11.5 6.2 2.6 1 1 0 2 2 2 0 Septum formation initiator DUF1664 PF07889.7 KII64798.1 - 0.12 12.2 12.9 0.026 14.3 3.4 2.4 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) DUF4164 PF13747.1 KII64798.1 - 0.12 12.5 9.4 0.088 12.9 0.6 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) EzrA PF06160.7 KII64798.1 - 0.12 10.4 15.2 0.048 11.8 4.8 2.1 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Vps5 PF09325.5 KII64798.1 - 0.12 11.5 9.2 0.04 13.1 1.4 2.1 2 0 0 2 2 2 0 Vps5 C terminal like WEMBL PF05701.6 KII64798.1 - 0.14 10.5 12.7 0.023 13.1 3.7 1.9 1 1 1 2 2 2 0 Weak chloroplast movement under blue light F_actin_bind PF08919.5 KII64798.1 - 0.16 11.6 7.8 14 5.4 5.4 2.3 1 1 0 1 1 1 0 F-actin binding DASH_Spc34 PF08657.5 KII64798.1 - 0.16 11.5 14.4 0.28 10.8 4.6 2.3 1 1 1 2 2 2 0 DASH complex subunit Spc34 V_ATPase_I PF01496.14 KII64798.1 - 0.18 9.6 5.0 0.23 9.2 3.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2051 PF09738.4 KII64798.1 - 0.18 11.0 11.1 0.98 8.6 2.2 2.1 2 0 0 2 2 2 0 Double stranded RNA binding protein (DUF2051) HrpB7 PF09486.5 KII64798.1 - 0.21 11.5 3.5 0.47 10.3 0.1 2.1 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Endonuc-BglII PF09195.6 KII64798.1 - 0.21 11.0 3.4 1.8 8.0 0.1 2.2 2 0 0 2 2 2 0 Restriction endonuclease BglII CENP-F_leu_zip PF10473.4 KII64798.1 - 0.23 11.3 16.0 0.06 13.1 5.9 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ApoO PF09769.4 KII64798.1 - 0.24 11.0 3.8 1.7 8.3 0.3 2.7 1 1 1 2 2 2 0 Apolipoprotein O Laminin_II PF06009.7 KII64798.1 - 0.24 11.1 11.6 0.064 13.0 1.8 2.3 3 0 0 3 3 2 0 Laminin Domain II Ax_dynein_light PF10211.4 KII64798.1 - 0.3 10.9 12.3 0.09 12.6 3.4 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain CHASE3 PF05227.8 KII64798.1 - 0.3 10.7 9.2 2.5 7.7 1.0 2.2 1 1 1 2 2 2 0 CHASE3 domain Occludin_ELL PF07303.8 KII64798.1 - 0.33 11.7 11.3 1.6 9.5 2.8 2.4 1 1 1 2 2 2 0 Occludin homology domain ARL2_Bind_BART PF11527.3 KII64798.1 - 0.37 10.5 5.7 0.22 11.3 1.5 2.0 2 0 0 2 2 2 0 The ARF-like 2 binding protein BART Syntaxin PF00804.20 KII64798.1 - 0.44 10.7 13.6 0.73 10.0 4.1 2.5 1 1 1 2 2 2 0 Syntaxin Decorin_bind PF02352.10 KII64798.1 - 0.47 10.4 5.1 42 4.1 3.5 2.3 1 1 0 1 1 1 0 Decorin binding protein AATF-Che1 PF13339.1 KII64798.1 - 0.47 10.6 11.6 2.8 8.1 2.4 2.3 1 1 0 2 2 2 0 Apoptosis antagonizing transcription factor YkuI_C PF10388.4 KII64798.1 - 0.48 10.0 6.6 0.71 9.5 4.2 1.6 1 1 0 1 1 1 0 EAL-domain associated signalling protein domain BRE1 PF08647.6 KII64798.1 - 0.49 10.3 14.7 0.45 10.5 5.5 2.3 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3847 PF12958.2 KII64798.1 - 0.5 10.1 13.6 0.13 12.0 2.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) TBPIP PF07106.8 KII64798.1 - 0.51 9.8 15.3 1.1 8.8 9.9 1.9 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Sigma70_ner PF04546.8 KII64798.1 - 0.53 9.8 6.1 2.6 7.5 0.9 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region BLOC1_2 PF10046.4 KII64798.1 - 0.58 10.3 11.9 0.47 10.6 2.4 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mei5 PF10376.4 KII64798.1 - 0.69 9.4 13.9 0.049 13.1 2.6 2.2 2 0 0 2 2 2 0 Double-strand recombination repair protein Fib_alpha PF08702.5 KII64798.1 - 0.71 9.9 17.3 0.18 11.9 2.9 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Lipoprotein_6 PF01441.14 KII64798.1 - 0.81 9.5 8.1 0.16 11.7 2.7 1.8 1 1 1 2 2 2 0 Lipoprotein Syntaxin-6_N PF09177.6 KII64798.1 - 0.98 9.8 9.5 2.9 8.3 2.9 2.7 2 1 0 2 2 2 0 Syntaxin 6, N-terminal ADIP PF11559.3 KII64798.1 - 0.99 9.2 19.8 0.13 12.1 7.0 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Mnd1 PF03962.10 KII64798.1 - 1 8.9 14.2 0.71 9.5 4.4 2.1 1 1 1 2 2 2 0 Mnd1 family DUF2400 PF09674.5 KII64798.1 - 1.2 8.8 6.1 0.52 9.9 2.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2400) RTBV_P46 PF06216.6 KII64798.1 - 1.3 7.7 7.3 0.25 10.1 2.3 1.7 1 1 1 2 2 2 0 Rice tungro bacilliform virus P46 protein 60KD_IMP PF02096.15 KII64798.1 - 1.3 8.5 7.3 10 5.6 1.9 2.1 2 0 0 2 2 2 0 60Kd inner membrane protein FemAB PF02388.11 KII64798.1 - 1.7 7.2 13.7 0.08 11.6 4.3 1.9 1 1 1 2 2 2 0 FemAB family DUF4404 PF14357.1 KII64798.1 - 1.7 9.1 8.1 0.15 12.5 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) CENP-Q PF13094.1 KII64798.1 - 1.8 8.5 17.1 7 6.6 11.9 1.8 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Prefoldin PF02996.12 KII64798.1 - 2.1 8.0 13.9 0.44 10.1 4.3 2.5 2 1 0 2 2 2 0 Prefoldin subunit Vac_Fusion PF02346.11 KII64798.1 - 2.3 7.6 7.0 5.4 6.5 1.8 2.6 2 1 0 2 2 2 0 Chordopoxvirus fusion protein SseC PF04888.7 KII64798.1 - 2.7 7.2 8.3 0.38 10.0 2.4 1.8 1 1 1 2 2 2 0 Secretion system effector C (SseC) like family DUF2203 PF09969.4 KII64798.1 - 2.8 8.2 8.1 38 4.5 5.6 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF1843 PF08898.5 KII64798.1 - 2.9 7.9 7.9 0.75 9.8 0.7 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1843) Atg14 PF10186.4 KII64798.1 - 3.1 6.6 16.5 0.5 9.2 6.7 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4140 PF13600.1 KII64798.1 - 3.3 8.2 7.9 0.92 9.9 1.0 2.6 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF724 PF05266.9 KII64798.1 - 3.7 7.1 12.3 1.4 8.5 6.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) PspA_IM30 PF04012.7 KII64798.1 - 3.9 6.7 13.0 3.1 7.0 3.5 2.0 1 1 0 2 2 2 0 PspA/IM30 family ORF6C PF10552.4 KII64798.1 - 4 7.2 11.1 2.4 7.8 5.4 2.2 1 1 1 2 2 2 0 ORF6C domain DUF2951 PF11166.3 KII64798.1 - 4.2 7.2 12.3 0.52 10.2 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) FlaC_arch PF05377.6 KII64798.1 - 4.3 7.2 11.1 1.8 8.5 3.9 2.7 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1043 PF06295.7 KII64798.1 - 4.6 6.9 10.7 18 4.9 7.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Fzo_mitofusin PF04799.8 KII64798.1 - 4.7 6.5 12.0 1.6 8.0 2.8 2.2 2 0 0 2 2 2 0 fzo-like conserved region DUF4446 PF14584.1 KII64798.1 - 4.9 6.9 9.8 1.6 8.5 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) GrpE PF01025.14 KII64798.1 - 5.2 6.5 13.6 3.4e+02 0.6 9.4 2.2 1 1 0 1 1 1 0 GrpE IL5 PF02025.10 KII64798.1 - 5.6 7.0 7.7 9.4 6.3 0.4 2.7 1 1 2 3 3 3 0 Interleukin 5 HR1 PF02185.11 KII64798.1 - 5.9 6.7 18.5 5.2 6.8 1.7 3.0 2 1 1 3 3 3 0 Hr1 repeat DUF2458 PF10454.4 KII64798.1 - 5.9 6.7 14.7 0.44 10.4 4.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2458) Takusan PF04822.8 KII64798.1 - 7.3 6.4 15.0 1.3 8.8 5.5 2.7 1 1 1 2 2 2 0 Takusan ACCA PF03255.9 KII64798.1 - 7.5 6.0 8.3 2.2 7.8 1.4 2.1 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Nup54 PF13874.1 KII64798.1 - 8.2 6.0 12.3 26 4.4 7.6 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 zf-C2H2_4 PF13894.1 KII64800.1 - 0.014 15.6 12.4 0.43 11.0 1.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Fer4_21 PF14697.1 KII64800.1 - 0.063 13.1 6.4 0.16 11.8 4.4 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain RVT_1 PF00078.22 KII64801.1 - 8.9e-12 44.8 0.0 1.1e-11 44.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.22 KII64802.1 - 0.0001 21.7 0.0 0.00018 20.9 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.22 KII64807.1 - 0.002 17.5 0.0 0.0042 16.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4070 PF13282.1 KII64808.1 - 0.0086 15.6 0.3 0.025 14.1 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4070) FA_FANCE PF11510.3 KII64809.1 - 0.012 14.7 0.0 0.015 14.4 0.0 1.1 1 0 0 1 1 1 0 Fanconi Anaemia group E protein FANCE Evr1_Alr PF04777.8 KII64809.1 - 0.053 13.4 0.2 1.7 8.5 0.0 2.1 2 0 0 2 2 2 0 Erv1 / Alr family Ubiquitin_3 PF14836.1 KII64809.1 - 0.09 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain DNA_pol_A_exo1 PF01612.15 KII64810.1 - 0.018 14.5 0.3 0.039 13.4 0.2 1.5 1 0 0 1 1 1 0 3'-5' exonuclease Nnf1 PF03980.9 KII64810.1 - 0.047 13.6 0.1 0.099 12.6 0.1 1.5 1 0 0 1 1 1 0 Nnf1 rve PF00665.21 KII64811.1 - 7.7e-17 61.5 0.0 1.6e-16 60.5 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII64811.1 - 2.8e-06 26.7 0.0 5.4e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain UBN2 PF14223.1 KII64812.1 - 0.00032 20.4 0.1 0.0014 18.4 0.0 2.1 1 1 1 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC_3 PF13917.1 KII64812.1 - 0.004 16.8 13.5 0.045 13.4 2.2 2.4 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.18 KII64812.1 - 0.0097 15.8 2.2 0.0097 15.8 1.5 2.7 2 0 0 2 2 2 1 Zinc knuckle gag-asp_proteas PF13975.1 KII64812.1 - 0.028 14.2 0.0 0.079 12.7 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII64812.1 - 0.11 12.9 0.0 0.33 11.4 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease RNA_pol PF00940.14 KII64812.1 - 0.12 10.8 0.0 0.17 10.2 0.0 1.2 1 0 0 1 1 1 0 DNA-dependent RNA polymerase DUF1192 PF06698.6 KII64812.1 - 0.23 11.2 1.5 2.2 8.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) zf-CCHC_4 PF14392.1 KII64812.1 - 3.8 7.2 11.5 3.1 7.5 0.3 2.8 2 0 0 2 2 2 0 Zinc knuckle OrfB_Zn_ribbon PF07282.6 KII64812.1 - 9.4 5.9 11.9 15 5.3 7.2 2.1 1 1 1 2 2 2 0 Putative transposase DNA-binding domain Augurin PF15187.1 KII64816.1 - 0.027 14.3 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 Oesophageal cancer-related gene 4 DUF3227 PF11537.3 KII64816.1 - 0.095 12.8 0.0 0.34 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3227) Gate PF07670.9 KII64817.1 - 0.09 12.6 0.2 0.16 11.9 0.1 1.5 1 1 0 1 1 1 0 Nucleoside recognition DUF3671 PF12420.3 KII64818.1 - 1.1 9.2 6.0 1.5 8.8 4.2 1.3 1 1 0 1 1 1 0 Protein of unknown function zf-C2H2_4 PF13894.1 KII64821.1 - 0.058 13.7 0.3 0.058 13.7 0.2 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 KII64821.1 - 0.074 13.1 1.3 0.084 13.0 0.1 1.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 KII64821.1 - 0.77 9.9 4.4 8.3 6.6 3.0 2.4 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 KII64821.1 - 2.5 8.6 8.4 0.35 11.3 2.2 2.3 2 1 0 2 2 2 0 Zinc finger, C2H2 type RVT_1 PF00078.22 KII64822.1 - 4.9e-08 32.5 0.0 7.7e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mononeg_RNA_pol PF00946.14 KII64824.1 - 0.0082 13.5 0.0 0.0099 13.3 0.0 1.1 1 0 0 1 1 1 1 Mononegavirales RNA dependent RNA polymerase DDE_Tnp_IS1595 PF12762.2 KII64825.1 - 5.9e-22 78.1 0.0 7.8e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII64826.1 - 1.1e-06 28.5 0.0 2.8e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII64827.1 - 5.9e-10 39.1 0.0 7.6e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII64827.1 - 0.1 11.8 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family rve PF00665.21 KII64828.1 - 6.8e-23 81.0 0.0 2.5e-22 79.2 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.5 KII64828.1 - 0.00026 20.3 0.0 0.00052 19.3 0.0 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII64828.1 - 0.028 13.9 0.0 0.08 12.4 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain RNase_E_G PF10150.4 KII64828.1 - 0.037 13.2 0.0 0.059 12.5 0.0 1.2 1 0 0 1 1 1 0 Ribonuclease E/G family TPR_11 PF13414.1 KII64830.1 - 4.1e-08 32.7 1.9 0.64 9.6 0.1 4.3 3 1 1 4 4 4 3 TPR repeat TPR_16 PF13432.1 KII64830.1 - 5e-05 23.8 0.0 3.2 8.5 0.0 4.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII64830.1 - 0.00013 21.4 5.1 3.3 7.7 0.2 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 KII64830.1 - 0.0004 20.3 1.0 2.1 8.7 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII64830.1 - 0.002 18.0 1.6 2.5 8.0 0.0 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 KII64830.1 - 0.0024 18.1 0.3 13 6.2 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat SPO22 PF08631.5 KII64830.1 - 0.0031 16.6 0.3 0.057 12.4 0.1 2.2 2 0 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.12 KII64830.1 - 0.0089 15.8 7.0 4 7.6 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 KII64830.1 - 0.022 15.3 0.0 1.1e+02 3.8 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat ChAPs PF09295.5 KII64830.1 - 0.023 13.4 0.0 0.12 11.1 0.0 2.2 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_1 PF00515.23 KII64830.1 - 0.045 13.3 10.6 11 5.7 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat Coatomer_E PF04733.9 KII64830.1 - 0.13 11.4 1.9 18 4.4 0.1 3.0 3 0 0 3 3 3 0 Coatomer epsilon subunit DDE_3 PF13358.1 KII64831.1 - 1.6e-06 27.8 0.1 5e-06 26.3 0.1 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII64832.1 - 0.04 13.9 2.7 0.097 12.7 1.9 1.6 1 1 0 1 1 1 0 Transposase DUF2222 PF09984.4 KII64832.1 - 0.065 12.6 0.2 0.1 12.0 0.1 1.3 1 1 0 1 1 1 0 Uncharacterized signal transduction histidine kinase domain (DUF2222) PNMA PF14893.1 KII64833.1 - 0.00084 18.4 0.0 0.00088 18.3 0.0 1.1 1 0 0 1 1 1 1 PNMA DUF257 PF03192.8 KII64833.1 - 0.055 12.7 0.0 0.094 12.0 0.0 1.3 1 0 0 1 1 1 0 Pyrococcus protein of unknown function, DUF257 FERM_C PF09380.5 KII64834.1 - 0.0064 16.6 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain Aida_N PF08910.5 KII64834.1 - 0.08 13.1 2.5 0.9 9.8 0.1 2.5 1 1 1 2 2 2 0 Aida N-terminus MCPVI PF02993.9 KII64834.1 - 0.32 11.1 4.8 0.48 10.5 3.3 1.3 1 0 0 1 1 1 0 Minor capsid protein VI Kinesin PF00225.18 KII64835.1 - 7e-62 209.0 2.1 7e-62 209.0 1.4 3.8 3 2 0 4 4 4 1 Kinesin motor domain Ribosomal_L22e PF01776.12 KII64836.1 - 0.053 13.5 5.1 0.92 9.5 0.1 2.4 2 0 0 2 2 2 0 Ribosomal L22e protein family PRP38 PF03371.10 KII64837.1 - 3.1e-49 166.8 0.0 5.2e-49 166.1 0.0 1.3 1 0 0 1 1 1 1 PRP38 family HSP90 PF00183.13 KII64837.1 - 0.061 11.7 2.4 0.082 11.2 1.7 1.1 1 0 0 1 1 1 0 Hsp90 protein YqfQ PF14181.1 KII64837.1 - 0.28 11.1 2.5 0.53 10.2 1.7 1.4 1 0 0 1 1 1 0 YqfQ-like protein CDC45 PF02724.9 KII64837.1 - 2.9 5.8 12.4 4 5.3 8.6 1.1 1 0 0 1 1 1 0 CDC45-like protein U3_assoc_6 PF08640.6 KII64838.1 - 3.9e-12 45.7 3.2 8.6e-12 44.6 2.2 1.6 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 RelA_SpoT PF04607.12 KII64839.1 - 0.038 13.9 0.1 0.083 12.9 0.1 1.5 1 0 0 1 1 1 0 Region found in RelA / SpoT proteins TMEM247 PF15444.1 KII64839.1 - 8.7 6.0 7.7 1.3 8.8 2.5 1.6 2 0 0 2 2 2 0 Transmembrane protein 247 SRP40_C PF05022.7 KII64840.1 - 1.3e-14 54.4 0.7 5.3e-14 52.4 0.5 2.2 1 0 0 1 1 1 1 SRP40, C-terminal domain DDE_3 PF13358.1 KII64841.1 - 6.3e-13 48.7 0.0 1.2e-12 47.8 0.0 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease KH_1 PF00013.24 KII64843.1 - 0.0057 16.2 0.0 1.8 8.2 0.0 2.1 2 0 0 2 2 2 2 KH domain HTH_29 PF13551.1 KII64844.1 - 1.1e-08 35.2 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII64844.1 - 1.5e-08 34.0 0.0 9.8e-06 25.0 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII64844.1 - 3.6e-06 26.8 0.0 0.00046 20.1 0.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.13 KII64844.1 - 8.2e-05 22.3 0.3 0.00048 19.8 0.2 1.9 1 1 1 2 2 2 1 'Paired box' domain HTH_32 PF13565.1 KII64844.1 - 0.0049 17.6 0.0 0.0085 16.8 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII64844.1 - 0.0057 16.3 0.2 0.0083 15.7 0.1 1.4 1 1 0 1 1 1 1 Transposase HTH_38 PF13936.1 KII64844.1 - 0.0074 15.8 0.1 0.41 10.2 0.0 2.8 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_Crp_2 PF13545.1 KII64844.1 - 0.016 15.0 0.1 0.15 11.8 0.0 2.2 2 1 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_7 PF02796.10 KII64844.1 - 0.061 13.1 2.0 0.38 10.6 0.2 2.9 3 1 0 3 3 3 0 Helix-turn-helix domain of resolvase Sigma70_r4_2 PF08281.7 KII64844.1 - 0.066 12.6 0.1 0.16 11.4 0.0 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_40 PF14493.1 KII64844.1 - 0.083 13.1 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII64844.1 - 0.086 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Transposase Dynamin_N PF00350.18 KII64846.1 - 1.4e-53 181.2 0.0 2.2e-53 180.5 0.0 1.3 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 KII64846.1 - 7.1e-33 113.6 0.1 1.2e-32 112.8 0.1 1.3 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.18 KII64846.1 - 7.2e-05 22.7 0.1 0.00023 21.1 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KII64846.1 - 0.005 17.3 0.0 0.0098 16.3 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein MobB PF03205.9 KII64846.1 - 0.065 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 KII64846.1 - 0.12 11.8 0.1 3.7 7.0 0.1 2.7 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation PH PF00169.24 KII64847.1 - 1.5e-08 34.7 3.1 1.7e-08 34.6 0.2 2.3 2 1 0 2 2 2 1 PH domain Dynamin_M PF01031.15 KII64847.1 - 9.5e-06 24.5 0.1 1.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region GED PF02212.13 KII64847.1 - 0.00037 20.3 0.3 0.00082 19.2 0.2 1.6 1 0 0 1 1 1 1 Dynamin GTPase effector domain GDPD_2 PF13653.1 KII64847.1 - 0.047 13.8 0.0 0.098 12.8 0.0 1.6 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Glyco_transf_54 PF04666.8 KII64849.1 - 2.4e-36 125.0 0.6 3e-36 124.7 0.4 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glycos_transf_2 PF00535.21 KII64849.1 - 0.00032 20.4 0.1 0.015 14.9 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 MGAT2 PF05060.9 KII64849.1 - 0.038 12.9 0.3 0.85 8.4 0.0 2.0 2 0 0 2 2 2 0 N-acetylglucosaminyltransferase II (MGAT2) Pkinase PF00069.20 KII64850.1 - 1.2e-54 185.2 0.0 1.5e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII64850.1 - 2.7e-39 134.8 0.0 3.9e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII64850.1 - 0.00024 20.1 0.0 0.00043 19.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like OSR1_C PF12202.3 KII64850.1 - 0.00082 18.9 0.0 0.0021 17.6 0.0 1.7 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C terminal Kdo PF06293.9 KII64850.1 - 0.029 13.4 0.0 0.05 12.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Dus PF01207.12 KII64850.1 - 0.16 10.8 0.0 0.27 10.0 0.0 1.3 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Adenylsucc_synt PF00709.16 KII64851.1 - 4.3e-153 509.9 0.0 4.9e-153 509.7 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DUF212 PF02681.9 KII64852.1 - 0.055 13.1 0.0 0.079 12.6 0.0 1.2 1 0 0 1 1 1 0 Divergent PAP2 family KH_1 PF00013.24 KII64855.1 - 0.00021 20.8 8.0 0.2 11.3 0.1 4.0 4 1 0 4 4 4 2 KH domain KH_3 PF13014.1 KII64855.1 - 0.063 12.9 0.1 0.24 11.1 0.1 2.0 1 0 0 1 1 1 0 KH domain DUF2732 PF10809.3 KII64858.1 - 0.018 14.5 0.2 0.025 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2732) DDE_3 PF13358.1 KII64859.1 - 2.6e-10 40.2 0.0 3.7e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Pkinase PF00069.20 KII64860.1 - 5.2e-57 192.9 0.0 8.1e-57 192.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII64860.1 - 3e-40 137.9 0.0 4.7e-40 137.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII64860.1 - 1.3e-06 27.5 0.0 2.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like OSR1_C PF12202.3 KII64860.1 - 0.00068 19.2 0.0 0.0013 18.3 0.0 1.5 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C terminal Kdo PF06293.9 KII64860.1 - 0.0015 17.6 0.1 0.0034 16.4 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FERM_C PF09380.5 KII64861.1 - 2.4e-16 59.6 0.3 6.1e-16 58.4 0.0 1.8 2 0 0 2 2 2 1 FERM C-terminal PH-like domain XFP PF03894.10 KII64861.1 - 0.19 11.3 4.3 3.9 7.0 0.3 2.4 2 0 0 2 2 2 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase ERM PF00769.14 KII64861.1 - 7.5 6.0 53.4 4.2e+02 0.2 37.0 3.2 1 1 0 1 1 1 0 Ezrin/radixin/moesin family GST_C_3 PF14497.1 KII64864.1 - 3.2e-07 30.7 0.0 6.3e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KII64864.1 - 0.0053 16.7 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain RVT_1 PF00078.22 KII64865.1 - 3.9e-21 75.3 0.1 8.9e-21 74.2 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII64865.1 - 2.3e-08 33.8 0.0 5.4e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII64865.1 - 3.1e-05 23.6 11.8 0.0029 17.4 1.9 2.5 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII64865.1 - 0.00028 21.3 0.0 0.00068 20.0 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII64865.1 - 0.00048 19.6 0.1 0.0017 17.8 0.1 2.0 1 1 0 1 1 1 1 Aspartyl protease zf-CCHC_3 PF13917.1 KII64865.1 - 0.0032 17.1 5.7 0.017 14.8 0.3 2.5 1 1 1 2 2 2 1 Zinc knuckle Zn_Tnp_IS91 PF14319.1 KII64865.1 - 0.018 14.5 2.8 0.053 13.0 1.9 1.7 1 0 0 1 1 1 0 Transposase zinc-binding domain Herpes_UL14 PF03580.9 KII64865.1 - 0.024 14.4 0.1 0.062 13.0 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL14-like protein gag-asp_proteas PF13975.1 KII64865.1 - 0.027 14.3 0.0 0.088 12.6 0.0 1.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Peptidase_A2B PF12384.3 KII64865.1 - 0.037 13.3 0.0 0.22 10.8 0.0 2.1 1 1 1 2 2 2 0 Ty3 transposon peptidase Spuma_A9PTase PF03539.9 KII64865.1 - 0.042 13.7 0.0 0.078 12.8 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP_2 PF08284.6 KII64865.1 - 0.043 13.7 0.1 0.078 12.9 0.1 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-ribbon_3 PF13248.1 KII64865.1 - 0.1 11.8 4.0 0.21 10.8 2.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-CCHC_5 PF14787.1 KII64865.1 - 0.39 10.2 10.4 0.2 11.1 0.8 2.6 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 KII64865.1 - 0.48 10.1 9.8 0.18 11.4 0.6 3.0 3 0 0 3 3 3 0 Zinc knuckle DUF2036 PF09724.4 KII64866.1 - 1.6e-58 198.4 0.7 1.9e-58 198.1 0.5 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) ORF6N PF10543.4 KII64866.1 - 0.0068 16.4 0.2 0.017 15.1 0.1 1.7 1 0 0 1 1 1 1 ORF6N domain SLD3 PF08639.5 KII64866.1 - 0.011 14.3 0.4 0.016 13.8 0.3 1.2 1 0 0 1 1 1 0 DNA replication regulator SLD3 SNAP PF14938.1 KII64867.1 - 4.4e-24 85.1 11.6 5.2e-24 84.8 8.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.1 KII64867.1 - 0.019 15.4 2.0 7.2 7.3 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat ODC_AZ PF02100.12 KII64868.1 - 7.3e-06 25.4 0.1 1e-05 24.9 0.1 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme DDE_1 PF03184.14 KII64869.1 - 3.7e-24 85.0 0.2 4.5e-24 84.8 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Rota_NS6 PF04866.7 KII64870.1 - 0.11 12.5 0.1 0.21 11.5 0.0 1.6 1 1 0 1 1 1 0 Rotavirus non-structural protein 6 Nucleoporin2 PF04096.9 KII64871.1 - 2.7e-34 117.9 0.1 5.6e-34 116.9 0.0 1.6 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.3 KII64871.1 - 3.6e-32 111.6 2.3 7.6e-32 110.5 1.6 1.5 1 0 0 1 1 1 1 Nuclear protein 96 HSP90 PF00183.13 KII64872.1 - 1.4e-216 720.0 30.7 1.7e-216 719.7 21.3 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.1 KII64872.1 - 2.4e-13 49.9 0.4 2.4e-13 49.9 0.3 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KII64872.1 - 3.5e-12 46.0 0.2 1.3e-11 44.2 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DDE_3 PF13358.1 KII64874.1 - 0.013 15.2 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Peptidase_A2B PF12384.3 KII64875.1 - 0.04 13.2 0.0 0.046 13.0 0.0 1.1 1 0 0 1 1 1 0 Ty3 transposon peptidase TBP PF00352.16 KII64876.1 - 2.6e-62 206.1 0.5 5.3e-32 109.0 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 KII64876.1 - 1.3e-07 31.5 0.0 0.022 14.7 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Myotub-related PF06602.9 KII64877.1 - 5.4e-15 55.0 0.9 7.7e-15 54.5 0.6 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Dimer_Tnp_hAT PF05699.9 KII64878.1 - 0.03 13.9 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region Sugar_tr PF00083.19 KII64879.1 - 2.4e-29 102.2 17.5 2.7e-29 102.0 12.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII64879.1 - 1.1e-07 30.8 14.9 1.8e-07 30.2 10.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2393 PF09624.5 KII64879.1 - 0.7 9.4 8.8 0.12 11.8 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) YibE_F PF07907.6 KII64879.1 - 0.74 8.9 20.0 0.025 13.7 3.3 2.4 2 1 0 2 2 2 0 YibE/F-like protein DUF4564 PF15169.1 KII64879.1 - 2.6 7.7 4.6 2 8.0 2.1 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4564) Sec7_N PF12783.2 KII64879.1 - 3.4 7.0 5.7 0.31 10.4 0.7 1.6 2 0 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Sugar_tr PF00083.19 KII64880.1 - 6.6e-07 28.2 0.1 7.6e-07 28.0 0.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Pox_A14 PF05767.7 KII64880.1 - 0.071 13.0 1.9 0.098 12.6 1.2 1.4 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF1538 PF07556.6 KII64880.1 - 0.1 11.6 1.4 0.12 11.4 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1538) EGF_2 PF07974.8 KII64881.1 - 0.0036 17.4 12.0 0.0063 16.6 8.3 1.4 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.22 KII64881.1 - 0.12 12.3 8.3 0.24 11.4 5.8 1.5 1 0 0 1 1 1 0 EGF-like domain EGF_MSP1_1 PF12946.2 KII64881.1 - 3.1 7.6 7.7 5.9 6.7 5.3 1.5 1 0 0 1 1 1 0 MSP1 EGF domain 1 EGF PF00008.22 KII64882.1 - 0.0055 16.6 3.3 0.026 14.5 2.3 2.1 1 1 0 1 1 1 1 EGF-like domain EGF_2 PF07974.8 KII64882.1 - 0.03 14.4 6.7 0.2 11.8 4.7 2.1 1 1 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.19 KII64882.1 - 0.49 10.3 3.4 0.84 9.6 2.3 1.5 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) Sugar_tr PF00083.19 KII64884.1 - 9e-25 87.1 2.0 1.1e-24 86.8 1.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII64884.1 - 4.6e-12 45.3 1.8 5.3e-12 45.1 1.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4131 PF13567.1 KII64884.1 - 0.094 12.1 1.3 14 5.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Sigma_1_2 PF03084.9 KII64884.1 - 0.12 11.0 0.0 0.4 9.2 0.0 1.7 1 1 1 2 2 2 0 Reoviral Sigma1/Sigma2 family MFS_2 PF13347.1 KII64884.1 - 0.12 10.7 6.0 0.018 13.4 0.5 1.9 2 0 0 2 2 2 0 MFS/sugar transport protein DDE_3 PF13358.1 KII64888.1 - 5.8e-20 71.5 0.0 6.8e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII64888.1 - 0.00014 21.1 0.0 0.00017 20.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_1 PF01344.20 KII64890.1 - 2e-18 65.6 20.5 3.7e-06 26.3 0.2 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.1 KII64890.1 - 5.5e-14 51.6 12.5 2.4e-05 24.3 0.0 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.1 KII64890.1 - 7.1e-14 51.3 14.5 1.5e-08 34.3 0.2 4.2 4 1 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 KII64890.1 - 8.9e-12 44.5 8.5 0.19 11.5 0.1 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII64890.1 - 3.6e-09 36.5 10.9 0.014 15.5 0.0 5.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KII64890.1 - 6.6e-07 28.8 10.6 0.62 9.9 0.1 5.2 5 0 0 5 5 5 3 Kelch motif AdoHcyase_NAD PF00670.16 KII64891.1 - 3.2e-37 127.8 0.3 3.8e-37 127.6 0.2 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.12 KII64891.1 - 1.3e-09 37.3 0.0 1.5e-09 37.1 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase 2-Hacid_dh_C PF02826.14 KII64891.1 - 0.0018 17.4 0.0 0.0022 17.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.14 KII64891.1 - 0.0025 16.8 0.7 0.0049 15.9 0.4 1.5 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AdoHcyase PF05221.12 KII64892.1 - 2e-69 233.5 0.2 2.3e-69 233.3 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase DUF223 PF02721.9 KII64893.1 - 0.11 12.6 0.2 0.14 12.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF223 Inhibitor_I29 PF08246.7 KII64894.1 - 3.1e-13 49.7 0.2 4.5e-13 49.2 0.2 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.18 KII64894.1 - 1.8e-08 34.5 0.2 2.9e-08 33.8 0.1 1.3 1 0 0 1 1 1 1 Papain family cysteine protease CENP-F_leu_zip PF10473.4 KII64896.1 - 8.3e-05 22.4 10.2 0.037 13.8 1.8 2.2 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.6 KII64896.1 - 0.072 12.9 6.9 1 9.1 1.4 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.7 KII64896.1 - 0.099 11.8 0.3 6.7 5.7 0.0 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein MscS_porin PF12795.2 KII64896.1 - 3.8 6.7 12.5 7.9 5.7 0.9 2.7 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Sugar_tr PF00083.19 KII64899.1 - 1.6e-55 188.4 20.3 2.1e-55 188.0 14.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII64899.1 - 2.4e-16 59.3 30.0 2.4e-16 59.3 20.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily rve PF00665.21 KII64900.1 - 5.7e-28 97.4 0.0 1.1e-27 96.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII64900.1 - 2.2e-24 86.0 0.0 4.9e-24 84.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII64900.1 - 0.0024 17.3 0.1 0.0056 16.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII64900.1 - 0.011 15.1 0.3 0.05 13.0 0.0 2.3 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger GSH_synth_ATP PF03917.12 KII64900.1 - 0.047 12.2 0.0 0.073 11.6 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain NurA PF09376.5 KII64902.1 - 0.13 11.7 0.1 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 NurA domain DDE_3 PF13358.1 KII64903.1 - 6.4e-06 25.9 0.0 7.9e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Homeobox PF00046.24 KII64904.1 - 6.4e-11 41.7 3.9 6.4e-11 41.7 2.7 1.8 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 KII64904.1 - 1.7e-08 34.0 0.2 3.4e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.3 KII64904.1 - 0.0011 17.9 0.1 0.0018 17.2 0.1 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez MltA PF03562.12 KII64904.1 - 0.025 14.3 0.1 0.032 13.9 0.1 1.3 1 0 0 1 1 1 0 MltA specific insert domain HTH_26 PF13443.1 KII64904.1 - 0.044 13.9 0.4 0.087 13.0 0.3 1.5 1 1 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain CTV_P13 PF06922.6 KII64905.1 - 0.11 12.4 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Citrus tristeza virus P13 protein Epsilon_antitox PF08998.6 KII64905.1 - 0.14 12.1 0.7 1.7 8.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial epsilon antitoxin Ribonuc_red_lgC PF02867.10 KII64906.1 - 1.2e-213 710.5 0.0 1.6e-213 710.1 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 KII64906.1 - 1.6e-20 72.6 0.0 4.4e-20 71.2 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 KII64906.1 - 1.8e-12 47.4 0.1 7e-12 45.6 0.0 2.1 2 0 0 2 2 2 1 ATP cone domain NRDD PF13597.1 KII64906.1 - 0.0023 16.0 0.0 0.0036 15.4 0.0 1.2 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase MOZ_SAS PF01853.13 KII64908.1 - 2.3e-81 271.5 0.5 3.7e-81 270.8 0.4 1.3 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.24 KII64908.1 - 2.8e-06 26.9 24.4 4.6e-05 23.0 2.7 3.1 2 1 1 3 3 3 2 PHD-finger UBA_3 PF09288.5 KII64908.1 - 0.13 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Serpin PF00079.15 KII64909.1 - 6.5e-48 163.7 2.6 7.4e-48 163.5 1.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.1 KII64913.1 - 8.9e-08 31.6 0.8 1.1e-07 31.2 0.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.1 KII64913.1 - 0.21 11.4 5.0 3 7.8 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat rve PF00665.21 KII64914.1 - 4e-28 97.9 0.0 7.4e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII64914.1 - 2.9e-05 23.7 3.4 2.9e-05 23.7 2.3 2.9 3 0 0 3 3 3 2 Zinc knuckle RVP PF00077.15 KII64914.1 - 6.9e-05 22.6 0.1 0.00021 21.1 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease DDE_Tnp_IS240 PF13610.1 KII64914.1 - 0.0023 17.9 0.6 0.0048 16.8 0.0 1.7 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII64914.1 - 0.01 15.3 0.0 0.03 13.8 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain zf-CCHC_4 PF14392.1 KII64914.1 - 0.063 12.9 9.4 0.16 11.6 1.1 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 KII64914.1 - 9.9 5.9 8.5 2.9 7.6 0.4 2.9 1 1 1 2 2 2 0 Zinc knuckle DDE_3 PF13358.1 KII64916.1 - 1e-10 41.5 0.0 1.2e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_M1 PF01433.15 KII64919.1 - 7.5e-99 331.4 2.1 3.3e-95 319.4 0.6 2.3 1 1 1 2 2 2 2 Peptidase family M1 ERAP1_C PF11838.3 KII64919.1 - 1.4e-21 77.1 0.0 2.4e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 KII64919.1 - 1.8e-11 44.1 5.1 3.8e-11 43.1 2.4 2.3 2 1 0 2 2 2 1 Peptidase MA superfamily DUF1360 PF07098.6 KII64919.1 - 0.094 12.4 0.2 0.28 10.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) TetR_C_8 PF14278.1 KII64919.1 - 0.18 12.2 5.7 7 7.1 0.2 3.8 4 0 0 4 4 4 0 Transcriptional regulator C-terminal region IstB_IS21_ATP PF08483.6 KII64919.1 - 0.21 11.3 3.4 0.2 11.3 1.1 1.9 2 0 0 2 2 2 0 IstB-like ATP binding N-terminal DUF240 PF03086.9 KII64922.1 - 0.098 12.2 2.3 0.1 12.2 1.1 1.5 1 1 0 1 1 1 0 MG032/MG096/MG288 family 2 DUF4064 PF13273.1 KII64924.1 - 2.7 8.1 13.0 3.5 7.7 7.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) MARVEL PF01284.18 KII64925.1 - 3.8e-05 23.5 7.0 0.00013 21.8 4.8 1.8 1 1 0 1 1 1 1 Membrane-associating domain DUF2583 PF10762.4 KII64925.1 - 0.25 11.5 2.5 5.4 7.2 0.0 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF2583) DUF2838 PF10998.3 KII64925.1 - 8.6 6.2 9.2 0.35 10.7 1.4 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2838) DDE_1 PF03184.14 KII64926.1 - 6.2e-08 32.0 0.4 1.6e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII64926.1 - 3e-05 23.7 1.4 5.5e-05 22.8 0.9 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain zf-UBR PF02207.15 KII64928.1 - 1e-12 47.5 13.6 2.3e-12 46.4 9.4 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-UBR PF02207.15 KII64930.1 - 2e-12 46.6 9.3 6.6e-12 44.9 6.5 1.9 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Laminin_EGF PF00053.19 KII64930.1 - 4.1 7.4 8.9 0.15 12.0 1.9 1.8 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) PHF5 PF03660.9 KII64930.1 - 7.5 6.6 9.4 1.2 9.1 3.4 2.0 2 0 0 2 2 2 0 PHF5-like protein Trehalose_recp PF06151.8 KII64931.1 - 0.087 11.1 0.2 0.1 10.9 0.2 1.1 1 0 0 1 1 1 0 Trehalose receptor Med26 PF08711.6 KII64932.1 - 1.4e-11 43.6 2.7 2.7e-11 42.7 1.4 1.8 1 1 1 2 2 2 1 TFIIS helical bundle-like domain LEDGF PF11467.3 KII64932.1 - 0.00069 19.2 0.5 0.001 18.7 0.3 1.2 1 0 0 1 1 1 1 Lens epithelium-derived growth factor (LEDGF) Tetraspannin PF00335.15 KII64933.1 - 4.6e-09 35.8 1.8 5.1e-09 35.7 1.2 1.0 1 0 0 1 1 1 1 Tetraspanin family Nuc_H_symport PF03825.11 KII64933.1 - 0.046 12.4 0.4 0.063 12.0 0.3 1.1 1 0 0 1 1 1 0 Nucleoside H+ symporter DUF3139 PF11337.3 KII64933.1 - 0.051 13.8 1.5 0.081 13.2 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Reticulon PF02453.12 KII64933.1 - 0.068 12.7 0.3 0.11 12.1 0.2 1.3 1 0 0 1 1 1 0 Reticulon Lactamase_B PF00753.22 KII64934.1 - 1e-13 51.3 0.2 1.6e-13 50.7 0.1 1.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KII64934.1 - 9.4e-06 25.2 0.0 1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PDEase_II PF02112.10 KII64934.1 - 0.059 12.2 0.1 0.078 11.8 0.1 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II DUF2428 PF10350.4 KII64937.1 - 3.9e-25 88.3 0.5 6.5e-25 87.6 0.4 1.3 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) FCH PF00611.18 KII64937.1 - 0.066 13.4 0.3 0.52 10.5 0.0 2.6 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain RE_Eco29kI PF09517.5 KII64937.1 - 0.11 11.8 0.1 0.34 10.2 0.1 1.8 1 0 0 1 1 1 0 Eco29kI restriction endonuclease Actin PF00022.14 KII64940.1 - 6.3e-38 130.2 0.0 7.3e-38 130.0 0.0 1.0 1 0 0 1 1 1 1 Actin Lectin_leg-like PF03388.8 KII64941.1 - 7.8e-56 188.7 0.1 1.1e-55 188.2 0.1 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.14 KII64941.1 - 1.6e-07 30.9 0.2 2.7e-07 30.2 0.1 1.4 1 1 0 1 1 1 1 Legume lectin domain JmjN PF02375.12 KII64941.1 - 0.03 13.8 0.3 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 jmjN domain PBP PF01161.15 KII64943.1 - 4.9e-05 23.2 0.0 0.00011 22.0 0.0 1.5 1 1 0 1 1 1 1 Phosphatidylethanolamine-binding protein ParD PF09386.5 KII64944.1 - 0.13 12.4 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Antitoxin ParD Rhodanese PF00581.15 KII64946.1 - 0.033 14.5 0.1 0.45 10.8 0.0 2.0 1 1 0 1 1 1 0 Rhodanese-like domain RVT_1 PF00078.22 KII64948.1 - 2.2e-13 50.0 0.5 4.3e-08 32.7 0.1 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L1 PF00687.16 KII64949.1 - 0.045 13.0 0.1 0.058 12.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L1p/L10e family DUF3564 PF12087.3 KII64949.1 - 0.098 12.2 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3564) DUF4293 PF14126.1 KII64956.1 - 0.018 14.9 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) RVT_1 PF00078.22 KII64960.1 - 3.1e-20 72.4 0.0 3.7e-20 72.2 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PmrD PF11183.3 KII64961.1 - 0.028 14.2 0.0 0.078 12.7 0.0 1.7 1 1 0 1 1 1 0 Polymyxin resistance protein PmrD RVT_1 PF00078.22 KII64963.1 - 1.9e-09 37.2 0.1 3.9e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII64963.1 - 0.00045 20.3 0.0 0.00098 19.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII64964.1 - 4.5e-24 84.8 0.0 5.6e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII64964.1 - 8e-07 28.4 0.1 1.1e-06 28.0 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII64964.1 - 8.3e-07 29.1 0.0 1.4e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_ISAZ013 PF07592.6 KII64964.1 - 0.048 12.3 0.0 0.051 12.3 0.0 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain Meiotic_rec114 PF03525.9 KII64964.1 - 0.072 11.5 0.1 0.083 11.3 0.1 1.0 1 0 0 1 1 1 0 Meiotic recombination protein rec114 DUF3573 PF12097.3 KII64966.1 - 0.014 14.0 0.6 0.022 13.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF972 PF06156.8 KII64966.1 - 3.8 7.9 7.8 0.94 9.8 3.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF972) EF_TS PF00889.14 KII64967.1 - 2.2e-07 30.4 0.2 0.0001 21.7 0.0 2.2 1 1 1 2 2 2 2 Elongation factor TS rve PF00665.21 KII64969.1 - 2.4e-21 76.0 0.0 5.9e-21 74.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII64969.1 - 7e-08 32.0 0.0 1.7e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII64969.1 - 0.0021 17.5 0.0 0.0072 15.8 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain MFS_1 PF07690.11 KII64970.1 - 9.4e-38 129.8 31.2 8.8e-36 123.3 11.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily VHL PF01847.11 KII64971.1 - 0.016 14.8 0.4 0.052 13.0 0.0 1.9 2 0 0 2 2 2 0 von Hippel-Lindau disease tumour suppressor protein DDE_Tnp_IS1595 PF12762.2 KII64972.1 - 7.1e-11 42.1 0.0 8.9e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain SlyX PF04102.7 KII64976.1 - 0.1 12.9 0.3 0.2 12.0 0.2 1.4 1 0 0 1 1 1 0 SlyX Rad9 PF04139.8 KII64977.1 - 0.058 12.5 0.4 0.12 11.4 0.1 1.6 1 1 1 2 2 2 0 Rad9 Amastin PF07344.6 KII64978.1 - 0.037 13.6 14.2 0.49 9.9 4.0 2.4 1 1 1 2 2 2 0 Amastin surface glycoprotein Acyl_transf_3 PF01757.17 KII64978.1 - 0.066 12.0 10.8 0.096 11.5 7.5 1.2 1 0 0 1 1 1 0 Acyltransferase family MARVEL PF01284.18 KII64978.1 - 0.61 9.9 14.1 2.8 7.7 9.9 1.8 1 1 0 1 1 1 0 Membrane-associating domain DUF3671 PF12420.3 KII64978.1 - 0.93 9.5 11.5 0.23 11.4 2.4 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF1772 PF08592.6 KII64978.1 - 3.8 7.2 7.5 0.55 9.9 1.2 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) 60KD_IMP PF02096.15 KII64978.1 - 5.6 6.5 12.3 0.061 12.9 3.2 1.8 2 1 0 2 2 2 0 60Kd inner membrane protein Peptidase_C6 PF00851.13 KII64979.1 - 0.025 13.2 3.6 0.032 12.8 2.5 1.1 1 0 0 1 1 1 0 Helper component proteinase Transketolase_N PF00456.16 KII64982.1 - 4.5e-62 209.7 0.0 1.6e-61 207.9 0.0 1.8 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 KII64982.1 - 1.2e-32 112.8 0.1 2.3e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 KII64982.1 - 1.2e-20 73.7 0.0 4.6e-20 71.7 0.0 2.0 2 0 0 2 2 2 1 Transketolase, C-terminal domain E1_dh PF00676.15 KII64982.1 - 3.9e-07 29.0 0.0 6.5e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 KII64982.1 - 1.3e-06 27.5 0.0 0.0028 16.6 0.0 2.5 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 KII64982.1 - 4.9e-05 22.9 0.1 0.00079 19.0 0.1 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.5 KII64982.1 - 0.019 13.5 0.0 0.034 12.7 0.0 1.3 1 0 0 1 1 1 0 XFP N-terminal domain CAP18_C PF12153.3 KII64982.1 - 0.1 12.2 0.2 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) COP-gamma_platf PF08752.5 KII64984.1 - 0.15 11.8 1.8 0.2 11.4 1.1 1.3 1 1 0 1 1 1 0 Coatomer gamma subunit appendage platform subdomain Galactosyl_T PF01762.16 KII64985.1 - 5.5e-30 104.4 0.2 7.9e-30 103.9 0.1 1.1 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.16 KII64988.1 - 5.7e-31 107.6 0.1 8.8e-31 107.0 0.1 1.3 1 0 0 1 1 1 1 Galactosyltransferase HsdM_N PF12161.3 KII64988.1 - 0.074 13.4 0.1 1.2 9.5 0.0 2.2 2 0 0 2 2 2 0 HsdM N-terminal domain Galactosyl_T PF01762.16 KII64989.1 - 1.8e-26 92.9 0.1 2.6e-26 92.4 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.16 KII64990.1 - 1.8e-26 92.9 0.1 2.6e-26 92.4 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.16 KII64991.1 - 6.5e-17 61.7 0.3 8.4e-17 61.4 0.2 1.2 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.16 KII64992.1 - 3.9e-08 33.1 0.1 4.2e-08 33.0 0.1 1.0 1 0 0 1 1 1 1 Galactosyltransferase DUF2012 PF09430.5 KII64992.1 - 0.11 12.2 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Galactosyl_T PF01762.16 KII64993.1 - 6.3e-31 107.5 0.1 9.8e-31 106.8 0.1 1.3 1 0 0 1 1 1 1 Galactosyltransferase HsdM_N PF12161.3 KII64993.1 - 0.083 13.3 0.1 1.3 9.4 0.0 2.2 2 0 0 2 2 2 0 HsdM N-terminal domain MULE PF10551.4 KII64995.1 - 3.9e-11 42.9 0.0 8.8e-11 41.8 0.0 1.6 2 0 0 2 2 2 1 MULE transposase domain Sec63 PF02889.11 KII64997.1 - 4.8e-190 630.4 5.0 6.7e-100 334.3 0.7 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 KII64997.1 - 1.7e-51 174.0 0.1 2e-31 108.7 0.1 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.10 KII64997.1 - 5.2e-13 49.2 0.0 8.9e-10 38.6 0.0 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 KII64997.1 - 2.3e-09 36.9 0.0 3e-07 30.2 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KII64997.1 - 0.00011 22.3 0.0 0.076 13.1 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KII64997.1 - 0.00018 21.1 0.0 0.82 9.4 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain T2SE PF00437.15 KII64997.1 - 0.00032 19.7 0.0 0.12 11.2 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_10 PF12846.2 KII64997.1 - 0.0009 18.7 0.4 0.51 9.7 0.0 3.3 3 0 0 3 3 3 2 AAA-like domain AAA_11 PF13086.1 KII64997.1 - 0.0011 18.5 1.5 0.1 12.1 0.0 3.3 3 1 1 4 4 4 1 AAA domain PhoH PF02562.11 KII64997.1 - 0.0043 16.3 0.0 2.3 7.4 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein FtsK_SpoIIIE PF01580.13 KII64997.1 - 0.0073 15.8 0.0 6.6 6.1 0.0 3.5 4 0 0 4 4 4 1 FtsK/SpoIIIE family AAA_25 PF13481.1 KII64997.1 - 0.013 14.8 0.0 0.74 9.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain adh_short PF00106.20 KII64998.1 - 2.1e-19 70.0 0.0 2.6e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KII64998.1 - 8.5e-09 35.3 0.0 1.3e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KII64998.1 - 1.1e-08 35.1 0.0 1.8e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 KII64998.1 - 4.9e-05 22.8 0.1 0.00013 21.5 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 KII64998.1 - 0.00017 21.3 0.0 0.0003 20.5 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.16 KII64998.1 - 0.00028 20.7 0.0 0.00058 19.6 0.0 1.5 1 0 0 1 1 1 1 ThiF family TrkA_N PF02254.13 KII64998.1 - 0.0056 16.6 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain ApbA PF02558.11 KII64998.1 - 0.02 14.3 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Polysacc_synt_2 PF02719.10 KII64998.1 - 0.042 12.7 0.0 0.065 12.1 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DapB_N PF01113.15 KII64998.1 - 0.045 13.6 0.1 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.14 KII64998.1 - 0.046 12.8 0.0 0.073 12.2 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Met_10 PF02475.11 KII64998.1 - 0.051 13.1 0.1 0.076 12.6 0.1 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Shikimate_DH PF01488.15 KII64998.1 - 0.053 13.6 0.0 0.097 12.7 0.0 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 KII64998.1 - 0.11 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Methyltransf_31 PF13847.1 KII64998.1 - 0.11 12.1 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain ExbD PF02472.11 KII64998.1 - 1.2 9.1 7.9 5.5 6.9 0.7 2.7 2 1 0 2 2 2 0 Biopolymer transport protein ExbD/TolR CPG4 PF15481.1 KII64998.1 - 1.4 9.3 4.9 0.84 10.0 0.1 2.6 3 0 0 3 3 3 0 Chondroitin proteoglycan 4 RVT_1 PF00078.22 KII65000.1 - 5.1e-29 101.1 0.0 1.2e-28 99.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII65000.1 - 5.3e-23 81.4 0.0 1e-22 80.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain gag-asp_proteas PF13975.1 KII65000.1 - 6e-07 29.2 0.0 1.1e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII65000.1 - 7.2e-07 29.0 0.0 1.7e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII65000.1 - 4.9e-06 26.2 3.9 4.9e-06 26.2 2.7 2.1 2 0 0 2 2 2 1 Zinc knuckle Asp_protease_2 PF13650.1 KII65000.1 - 0.00018 21.9 0.0 0.0005 20.5 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_6 PF15288.1 KII65000.1 - 0.017 14.7 3.0 0.064 12.9 2.1 2.0 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII65000.1 - 0.018 14.6 1.7 0.075 12.7 1.2 2.1 1 0 0 1 1 1 0 Zinc knuckle zf-H2C2 PF09337.5 KII65000.1 - 0.022 14.1 0.0 0.059 12.7 0.0 1.8 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger Asp_protease PF09668.5 KII65000.1 - 0.047 13.2 0.0 0.23 11.0 0.0 2.1 2 0 0 2 2 2 0 Aspartyl protease RVP_2 PF08284.6 KII65000.1 - 0.059 13.3 0.0 0.2 11.5 0.0 1.9 1 0 0 1 1 1 0 Retroviral aspartyl protease Ldl_recept_a PF00057.13 KII65002.1 - 6.9e-28 96.2 85.8 9.2e-11 41.4 9.5 5.5 6 1 0 6 6 6 4 Low-density lipoprotein receptor domain class A BamHI PF02923.10 KII65004.1 - 0.055 13.4 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease BamHI Ldl_recept_a PF00057.13 KII65007.1 - 5.1e-24 83.8 49.9 1.6e-11 43.8 8.6 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII65007.1 - 0.004 16.7 26.4 0.12 11.9 11.3 2.7 1 1 1 2 2 2 2 Glucosidase II beta subunit-like F_actin_bind PF08919.5 KII65008.1 - 0.026 14.2 0.1 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 F-actin binding Isochorismatase PF00857.15 KII65011.1 - 5.5e-25 88.3 0.3 3e-24 85.8 0.2 1.9 1 1 0 1 1 1 1 Isochorismatase family DUF1082 PF06449.6 KII65015.1 - 0.052 13.4 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 Mitochondrial domain of unknown function (DUF1082) Sec23_helical PF04815.10 KII65015.1 - 0.11 11.9 0.0 0.22 10.9 0.0 1.6 1 0 0 1 1 1 0 Sec23/Sec24 helical domain PFK PF00365.15 KII65020.1 - 3.9e-44 150.7 0.3 4.9e-44 150.3 0.2 1.1 1 0 0 1 1 1 1 Phosphofructokinase Myosin_N PF02736.14 KII65020.1 - 0.035 13.7 0.0 0.069 12.8 0.0 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain PfkB PF00294.19 KII65021.1 - 7.6e-41 140.1 0.1 7.8e-40 136.8 0.1 2.0 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 KII65021.1 - 9.1e-18 64.3 0.0 1.7e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase HTH_DeoR PF08220.7 KII65021.1 - 3.5e-12 45.6 0.1 6.2e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain DUF2250 PF10007.4 KII65021.1 - 0.00069 19.4 0.0 0.0018 18.1 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_11 PF08279.7 KII65021.1 - 0.0057 16.2 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 HTH domain Carb_kinase PF01256.12 KII65021.1 - 0.012 14.8 0.1 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate kinase FeoC PF09012.5 KII65021.1 - 0.02 14.5 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator GntR PF00392.16 KII65021.1 - 0.023 14.1 0.0 0.058 12.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DHDPS PF00701.17 KII65022.1 - 3.3e-24 85.0 0.0 3.8e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF386 PF04074.7 KII65023.1 - 7.9e-32 109.8 0.0 9.1e-32 109.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF386) Peripla_BP_3 PF13377.1 KII65025.1 - 5e-20 72.1 0.0 8.1e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.16 KII65025.1 - 0.0025 17.0 0.1 0.0031 16.7 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family RRM_1 PF00076.17 KII65026.1 - 3.2e-16 58.7 0.1 5.4e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII65026.1 - 6.6e-13 48.4 0.0 1.1e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII65026.1 - 2.7e-07 30.3 0.0 5.3e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 KII65026.1 - 3.1e-05 24.3 2.4 3.1e-05 24.3 1.6 2.0 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Albumin_I PF08027.6 KII65028.1 - 0.68 9.6 5.1 2.6 7.7 0.1 2.2 2 0 0 2 2 2 0 Albumin I zf-CCHC PF00098.18 KII65029.1 - 1.6e-05 24.6 2.1 2.6e-05 23.9 1.4 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 KII65029.1 - 0.096 12.3 2.0 0.28 10.8 1.4 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-like PF04071.7 KII65030.1 - 0.032 13.9 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Cysteine-rich small domain CesA PF11439.3 KII65030.1 - 0.1 12.5 1.0 3.3 7.7 0.0 2.6 2 1 0 2 2 2 0 Type III secretion system filament chaperone CesA Nic96 PF04097.9 KII65033.1 - 7.2e-15 54.1 3.8 6.9e-14 50.9 2.6 1.9 1 1 0 1 1 1 1 Nup93/Nic96 SIP1 PF04938.7 KII65033.1 - 0.1 11.9 0.1 0.26 10.6 0.0 1.6 2 0 0 2 2 2 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) CH PF00307.26 KII65035.1 - 4e-61 203.7 6.0 4.2e-16 58.9 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KII65035.1 - 3.4e-14 52.2 0.2 4.1e-07 29.5 0.0 3.8 4 0 0 4 4 4 2 CAMSAP CH domain DUF2877 PF11392.3 KII65035.1 - 0.088 13.0 0.1 2.7 8.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2877) AMP-binding_C_2 PF14535.1 KII65036.1 - 0.067 13.2 0.2 0.12 12.4 0.2 1.4 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain L31 PF09784.4 KII65038.1 - 1.1 9.3 5.9 3.1 7.9 1.3 2.2 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 DUF4473 PF14747.1 KII65039.1 - 0.068 13.3 0.1 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) OB_NTP_bind PF07717.11 KII65040.1 - 1.2e-29 102.4 0.1 2.7e-29 101.2 0.1 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 KII65040.1 - 7.8e-26 90.0 0.5 4.6e-25 87.6 0.1 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 KII65040.1 - 6.6e-13 48.3 0.0 1.6e-12 47.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KII65040.1 - 6.4e-05 23.1 0.0 0.0002 21.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 KII65040.1 - 0.00015 21.3 0.1 0.001 18.6 0.1 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 KII65040.1 - 0.0019 17.1 0.0 0.0039 16.1 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.4 KII65040.1 - 0.0043 16.0 0.0 0.0072 15.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.17 KII65040.1 - 0.014 14.8 0.0 0.055 12.9 0.0 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_19 PF13245.1 KII65040.1 - 0.019 14.7 0.0 0.053 13.2 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain ResIII PF04851.10 KII65040.1 - 0.024 14.4 0.0 2.3 8.0 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 KII65040.1 - 0.024 14.4 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_30 PF13604.1 KII65040.1 - 0.026 14.1 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain SecA_DEAD PF07517.9 KII65040.1 - 0.05 12.8 0.0 0.094 11.9 0.0 1.4 1 0 0 1 1 1 0 SecA DEAD-like domain AAA_11 PF13086.1 KII65040.1 - 0.099 12.2 0.2 0.32 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 KII65040.1 - 9.1 6.5 8.7 1.7 8.8 1.4 2.2 1 1 1 2 2 2 0 AAA domain TPR_11 PF13414.1 KII65041.1 - 1.3e-54 181.6 18.3 4e-08 32.7 0.0 10.3 6 3 4 11 11 11 11 TPR repeat TPR_2 PF07719.12 KII65041.1 - 4e-47 154.3 17.8 8.7e-06 25.2 0.0 14.5 15 0 0 15 15 14 9 Tetratricopeptide repeat TPR_1 PF00515.23 KII65041.1 - 1.7e-43 144.4 35.3 3.6e-07 29.5 0.0 15.0 16 1 0 16 16 16 8 Tetratricopeptide repeat TPR_12 PF13424.1 KII65041.1 - 5.3e-39 132.0 10.6 1.8e-10 40.5 0.0 9.4 7 2 4 11 11 10 8 Tetratricopeptide repeat TPR_14 PF13428.1 KII65041.1 - 8.3e-39 128.5 0.0 3.3e-05 24.1 0.0 13.3 6 5 7 13 13 13 8 Tetratricopeptide repeat TPR_19 PF14559.1 KII65041.1 - 1.1e-38 131.3 0.2 0.00039 20.6 0.0 10.7 6 4 7 13 13 13 10 Tetratricopeptide repeat TPR_16 PF13432.1 KII65041.1 - 1.4e-36 124.3 0.0 2.1e-08 34.6 0.0 11.3 7 3 5 12 12 12 6 Tetratricopeptide repeat TPR_8 PF13181.1 KII65041.1 - 7.4e-29 97.3 26.4 0.0017 17.9 0.0 11.8 12 1 1 13 13 12 6 Tetratricopeptide repeat TPR_6 PF13174.1 KII65041.1 - 4.1e-25 86.4 9.1 9.1e-05 22.6 0.1 12.8 15 0 0 15 15 13 5 Tetratricopeptide repeat TPR_7 PF13176.1 KII65041.1 - 3e-23 79.7 3.6 0.0034 17.0 0.0 10.5 12 0 0 12 12 11 4 Tetratricopeptide repeat TPR_17 PF13431.1 KII65041.1 - 1e-21 75.2 26.4 0.57 10.5 0.0 16.2 18 0 0 18 18 17 5 Tetratricopeptide repeat Apc3 PF12895.2 KII65041.1 - 1.5e-15 57.0 20.3 0.00024 21.1 1.0 8.2 6 3 3 9 9 9 6 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.3 KII65041.1 - 6.2e-11 41.7 0.1 6.2e-11 41.7 0.0 3.5 4 0 0 4 4 4 1 NMDA receptor-regulated protein 1 TPR_10 PF13374.1 KII65041.1 - 8e-11 41.4 5.4 0.04 13.8 0.0 8.0 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 KII65041.1 - 5.5e-09 35.7 0.0 0.0076 16.0 0.0 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII65041.1 - 0.00033 20.4 7.4 0.32 10.8 0.0 5.3 6 0 0 6 6 5 2 Fis1 C-terminal tetratricopeptide repeat Peptidase_M24 PF00557.19 KII65044.1 - 0.047 13.2 0.1 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 Metallopeptidase family M24 Peptidase_M24 PF00557.19 KII65045.1 - 4e-34 118.0 0.0 5e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 ADIP PF11559.3 KII65047.1 - 0.022 14.6 4.0 0.022 14.6 2.8 1.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Fib_alpha PF08702.5 KII65047.1 - 0.097 12.7 4.0 0.13 12.4 2.8 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3496 PF12001.3 KII65047.1 - 0.19 12.0 4.1 0.3 11.3 2.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3496) Med28 PF11594.3 KII65047.1 - 0.2 11.9 3.7 0.31 11.2 2.5 1.5 1 1 0 1 1 1 0 Mediator complex subunit 28 Kinesin-relat_1 PF12711.2 KII65047.1 - 0.39 11.1 5.4 2.1 8.8 2.6 2.4 1 1 0 1 1 1 0 Kinesin motor DUF904 PF06005.7 KII65047.1 - 9.4 6.6 9.3 5.2 7.4 2.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF904) AAA PF00004.24 KII65049.1 - 7.5e-53 178.2 0.2 5.8e-39 133.3 0.1 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KII65049.1 - 5.3e-10 39.5 2.6 0.0033 17.5 0.1 4.2 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 KII65049.1 - 8.8e-08 31.9 0.6 0.0016 18.1 0.1 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 KII65049.1 - 9.2e-08 32.1 0.0 4.6e-06 26.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) KaiC PF06745.8 KII65049.1 - 4.4e-07 29.2 0.3 0.01 14.9 0.0 2.6 2 0 0 2 2 2 2 KaiC AAA_17 PF13207.1 KII65049.1 - 2.6e-06 28.2 0.1 0.0063 17.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain CDC48_N PF02359.13 KII65049.1 - 4.6e-06 26.4 0.0 5.4e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain TIP49 PF06068.8 KII65049.1 - 6.2e-06 25.1 0.1 0.08 11.6 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus AAA_18 PF13238.1 KII65049.1 - 1.3e-05 25.5 0.0 0.013 15.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 KII65049.1 - 1.3e-05 24.4 0.5 0.0042 16.2 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 KII65049.1 - 1.4e-05 25.2 0.4 0.11 12.4 0.0 2.8 2 1 0 3 3 3 2 AAA ATPase domain AAA_14 PF13173.1 KII65049.1 - 2e-05 24.4 0.2 0.17 11.7 0.0 2.8 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 KII65049.1 - 3.4e-05 23.3 1.3 0.042 13.2 0.0 2.9 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_25 PF13481.1 KII65049.1 - 0.00011 21.6 0.7 0.14 11.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 KII65049.1 - 0.00016 21.2 0.5 0.56 9.6 0.0 2.7 3 0 0 3 3 2 2 Sigma-54 interaction domain RNA_helicase PF00910.17 KII65049.1 - 0.00016 21.7 0.1 0.11 12.6 0.0 2.9 3 0 0 3 3 2 1 RNA helicase AAA_19 PF13245.1 KII65049.1 - 0.00025 20.7 2.6 0.079 12.7 0.0 2.9 3 0 0 3 3 2 1 Part of AAA domain AAA_33 PF13671.1 KII65049.1 - 0.00033 20.5 0.0 0.14 11.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain CDC48_2 PF02933.12 KII65049.1 - 0.00041 19.9 0.6 0.0013 18.3 0.0 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), domain 2 Zeta_toxin PF06414.7 KII65049.1 - 0.00043 19.4 0.1 0.96 8.5 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_3 PF07726.6 KII65049.1 - 0.00083 18.9 0.0 0.011 15.3 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 KII65049.1 - 0.0009 18.5 0.1 1.1 8.4 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_24 PF13479.1 KII65049.1 - 0.00095 18.7 0.5 0.29 10.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain NACHT PF05729.7 KII65049.1 - 0.0013 18.3 2.8 3.4 7.3 0.0 3.8 4 0 0 4 4 4 1 NACHT domain RuvB_N PF05496.7 KII65049.1 - 0.0016 17.5 0.1 0.047 12.7 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Sigma54_activ_2 PF14532.1 KII65049.1 - 0.0019 18.2 0.1 1.4 8.9 0.0 2.9 2 1 0 2 2 2 1 Sigma-54 interaction domain UPF0079 PF02367.12 KII65049.1 - 0.0046 16.5 0.2 1.2 8.7 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 ABC_tran PF00005.22 KII65049.1 - 0.0068 16.7 1.0 0.11 12.7 0.1 2.4 2 0 0 2 2 2 1 ABC transporter AAA_28 PF13521.1 KII65049.1 - 0.018 15.0 0.0 2.1 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain IPT PF01745.11 KII65049.1 - 0.021 14.0 0.0 0.57 9.3 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase DEAD PF00270.24 KII65049.1 - 0.021 14.3 1.1 16 4.9 0.1 3.8 2 2 0 4 4 4 0 DEAD/DEAH box helicase Parvo_NS1 PF01057.12 KII65049.1 - 0.021 13.6 0.0 2.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Terminase_2 PF03592.11 KII65049.1 - 0.04 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 Terminase small subunit KTI12 PF08433.5 KII65049.1 - 0.055 12.6 0.1 0.28 10.3 0.0 2.1 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_30 PF13604.1 KII65049.1 - 0.088 12.3 0.0 0.63 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 KII65049.1 - 0.11 11.4 0.1 7.7 5.3 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.4 KII65049.1 - 0.11 11.0 0.2 2.2 6.8 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Arch_ATPase PF01637.13 KII65049.1 - 0.34 10.5 2.3 18 4.9 0.2 3.4 3 1 1 4 4 4 0 Archaeal ATPase RhoGAP PF00620.22 KII65050.1 - 2.7e-20 72.5 0.3 1.9e-09 37.3 0.1 2.3 1 1 1 2 2 2 2 RhoGAP domain NUC173 PF08161.7 KII65052.1 - 1.7e-05 24.2 1.3 9.4e-05 21.8 0.4 2.5 3 0 0 3 3 3 1 NUC173 domain BCIP PF13862.1 KII65054.1 - 9.8e-07 28.4 0.3 0.0015 18.0 0.0 2.5 1 1 2 3 3 3 2 p21-C-terminal region-binding protein LacI PF00356.16 KII65058.1 - 0.48 10.0 0.1 0.48 10.0 0.1 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family PAP2 PF01569.16 KII65059.1 - 2.5e-14 53.0 2.8 2.8e-14 52.9 2.0 1.0 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.9 KII65059.1 - 0.0019 17.9 0.0 0.27 10.9 0.0 2.2 2 0 0 2 2 2 2 Divergent PAP2 family Polysacc_synt_C PF14667.1 KII65059.1 - 0.11 12.2 5.2 0.14 12.0 3.6 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain FecCD PF01032.13 KII65059.1 - 0.12 11.2 1.8 0.14 10.9 1.2 1.1 1 0 0 1 1 1 0 FecCD transport family DUF2768 PF10966.3 KII65059.1 - 0.29 11.2 6.5 0.27 11.4 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) Multi_Drug_Res PF00893.14 KII65059.1 - 0.32 11.4 3.8 0.36 11.3 2.3 1.4 1 1 0 1 1 1 0 Small Multidrug Resistance protein DUF4199 PF13858.1 KII65059.1 - 0.54 10.1 7.3 0.074 12.9 1.6 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF4199) RRM_5 PF13893.1 KII65060.1 - 0.0033 17.2 0.0 1.6 8.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII65060.1 - 0.024 14.2 1.8 2.3 7.9 0.0 3.4 3 2 1 4 4 4 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII65060.1 - 0.026 14.5 0.1 0.11 12.4 0.0 2.2 3 1 0 3 3 3 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Rsm22 PF09243.5 KII65063.1 - 6.7e-05 22.0 0.0 0.00013 21.1 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 PRP8_domainIV PF12134.3 KII65063.1 - 0.038 13.3 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 PRP8 domain IV core DUF1011 PF06237.7 KII65063.1 - 0.089 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1011) GLE1 PF07817.8 KII65064.1 - 0.11 11.3 0.3 0.12 11.3 0.2 1.1 1 0 0 1 1 1 0 GLE1-like protein Tropomyosin PF00261.15 KII65065.1 - 1.5e-05 24.1 36.4 2.4e-05 23.5 25.3 1.2 1 0 0 1 1 1 1 Tropomyosin UDPGT PF00201.13 KII65065.1 - 0.046 12.2 1.5 0.055 12.0 0.9 1.3 1 1 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Tropomyosin_1 PF12718.2 KII65065.1 - 0.088 12.6 36.1 2 8.2 8.6 3.1 1 1 2 3 3 3 0 Tropomyosin like IncA PF04156.9 KII65065.1 - 0.096 12.2 36.3 0.31 10.6 3.9 3.0 1 1 2 3 3 3 0 IncA protein DUF4522 PF15022.1 KII65065.1 - 0.16 11.6 5.2 0.089 12.5 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4522) GAS PF13851.1 KII65065.1 - 0.29 10.2 36.1 0.049 12.8 7.3 3.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ADIP PF11559.3 KII65065.1 - 0.35 10.7 37.5 0.15 11.9 7.9 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.7 KII65065.1 - 0.86 8.7 17.3 1.5 7.9 0.6 2.8 1 1 2 3 3 3 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 KII65065.1 - 1.2 8.9 36.8 0.94 9.2 1.7 4.2 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein MtrB PF05440.7 KII65065.1 - 2 8.5 6.2 6.8 6.8 0.2 3.2 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B Spc7 PF08317.6 KII65065.1 - 2.3 6.7 36.7 5.4 5.5 12.7 2.9 1 1 2 3 3 3 0 Spc7 kinetochore protein SPX PF03105.14 KII65065.1 - 3.4 7.3 23.6 15 5.2 16.3 1.8 1 1 0 1 1 1 0 SPX domain TrkA_N PF02254.13 KII65065.1 - 3.7 7.5 6.1 0.38 10.7 0.5 2.1 3 0 0 3 3 3 0 TrkA-N domain M_domain PF12938.2 KII65065.1 - 4.2 7.1 11.5 0.65 9.7 0.9 2.2 2 0 0 2 2 2 0 M domain of GW182 Atg14 PF10186.4 KII65065.1 - 4.5 6.1 34.4 1.2 8.0 3.9 2.9 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 V_ATPase_I PF01496.14 KII65065.1 - 5.6 4.6 27.0 3.3 5.4 6.0 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Mod_r PF07200.8 KII65065.1 - 8.1 6.3 31.3 1.5 8.7 3.6 3.1 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF972 PF06156.8 KII65065.1 - 8.4 6.7 29.5 5.7 7.3 3.8 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF972) ERM PF00769.14 KII65065.1 - 9.3 5.7 35.0 1.5 8.3 7.6 2.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family FUSC PF04632.7 KII65065.1 - 9.7 4.4 6.5 12 4.1 4.5 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Serinc PF03348.10 KII65068.1 - 1.3e-105 353.5 32.2 4.6e-105 351.7 22.3 1.7 1 1 0 1 1 1 1 Serine incorporator (Serinc) DUF2207 PF09972.4 KII65068.1 - 0.94 7.9 6.8 2.5 6.5 4.7 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Pkinase PF00069.20 KII65069.1 - 4.3e-47 160.4 0.0 5.2e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII65069.1 - 2.2e-25 89.1 0.0 2.7e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII65069.1 - 0.021 13.7 0.0 0.04 12.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like AA_permease_2 PF13520.1 KII65074.1 - 1.1e-44 152.7 61.3 1.3e-44 152.4 42.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII65074.1 - 5.2e-26 91.0 54.7 7.4e-26 90.5 37.9 1.2 1 1 0 1 1 1 1 Amino acid permease NOSIC PF08060.8 KII65075.1 - 3.5e-12 45.9 0.1 5.2e-12 45.3 0.1 1.3 1 0 0 1 1 1 1 NOSIC (NUC001) domain rve PF00665.21 KII65076.1 - 1.5e-21 76.7 0.0 2.7e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65076.1 - 6.1e-06 25.6 0.0 1.9e-05 24.1 0.0 1.9 1 1 0 1 1 1 1 Integrase core domain Agenet PF05641.7 KII65076.1 - 0.059 13.5 0.2 0.51 10.5 0.1 2.2 2 0 0 2 2 2 0 Agenet domain Peptidase_S8 PF00082.17 KII65078.1 - 1.7e-46 158.6 0.4 2.6e-46 158.0 0.3 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 KII65078.1 - 1.3e-24 85.7 0.1 3.7e-24 84.3 0.0 1.7 2 0 0 2 2 2 1 Proprotein convertase P-domain Antimicrobial_5 PF08026.6 KII65080.1 - 0.016 15.0 2.4 0.026 14.3 1.7 1.3 1 0 0 1 1 1 0 Bee antimicrobial peptide RhoGAP PF00620.22 KII65081.1 - 2e-05 24.2 0.0 7.1e-05 22.4 0.0 1.9 1 1 1 2 2 2 1 RhoGAP domain Fumble PF03630.9 KII65082.1 - 2e-100 335.9 3.9 3.1e-100 335.3 2.7 1.3 1 0 0 1 1 1 1 Fumble DUF89 PF01937.14 KII65082.1 - 5.2e-16 58.3 0.0 5e-14 51.8 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function DUF89 CDC50 PF03381.10 KII65084.1 - 2.8e-51 174.3 2.2 2.8e-51 174.3 1.5 1.6 1 1 1 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CUB_2 PF02408.15 KII65084.1 - 0.0043 16.5 0.3 0.0092 15.5 0.2 1.5 1 0 0 1 1 1 1 CUB-like domain zf-C2H2 PF00096.21 KII65085.1 - 0.00032 20.8 1.7 0.00075 19.6 1.2 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII65085.1 - 0.00044 20.3 0.5 0.0014 18.7 0.3 1.9 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII65085.1 - 0.0012 18.9 0.2 0.0031 17.6 0.1 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 KII65085.1 - 0.0018 18.4 3.5 0.017 15.3 0.2 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-met PF12874.2 KII65085.1 - 0.031 14.4 0.8 0.084 13.1 0.5 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Elf1 PF05129.8 KII65085.1 - 0.062 13.0 1.9 0.12 12.0 1.0 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-C2H2_6 PF13912.1 KII65085.1 - 0.12 12.3 0.4 0.33 10.9 0.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-BED PF02892.10 KII65085.1 - 0.25 11.1 2.1 0.54 10.0 1.5 1.5 1 0 0 1 1 1 0 BED zinc finger DUF1178 PF06676.6 KII65085.1 - 0.29 11.3 2.3 0.31 11.2 0.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) zf-C2H2 PF00096.21 KII65086.1 - 0.00045 20.4 0.2 0.0007 19.7 0.1 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII65086.1 - 0.022 15.0 0.1 0.042 14.1 0.1 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KII65086.1 - 0.43 10.9 2.2 0.38 11.1 0.4 1.7 2 0 0 2 2 2 0 Zinc-finger double domain DDE_3 PF13358.1 KII65087.1 - 2e-06 27.6 0.2 3.4e-06 26.8 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease FLYWCH PF04500.11 KII65088.1 - 1.7e-07 30.9 6.1 2.4e-07 30.5 4.2 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain FLYWCH PF04500.11 KII65089.1 - 1.7e-07 30.9 6.1 2.4e-07 30.5 4.2 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain gag-asp_proteas PF13975.1 KII65090.1 - 0.00043 20.0 0.0 0.00073 19.3 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII65090.1 - 0.01 15.7 0.3 0.91 9.4 0.0 2.5 1 1 1 2 2 2 0 Retroviral aspartyl protease Exo70 PF03081.10 KII65091.1 - 3.2e-08 32.7 10.2 3e-07 29.5 7.1 2.4 1 1 0 1 1 1 1 Exo70 exocyst complex subunit PAS PF00989.19 KII65092.1 - 0.0011 18.7 0.0 0.0036 17.0 0.0 1.8 1 1 0 1 1 1 1 PAS fold PAS_9 PF13426.1 KII65092.1 - 0.0037 17.6 0.0 0.0057 17.0 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_2 PF08446.6 KII65092.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.6 1 1 1 2 2 2 0 PAS fold DDE_3 PF13358.1 KII65095.1 - 2.1e-12 47.0 0.0 2.6e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII65097.1 - 8.3e-05 22.3 0.0 9.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_M76 PF09768.4 KII65097.1 - 0.097 12.1 1.1 0.16 11.4 0.8 1.5 1 1 0 1 1 1 0 Peptidase M76 family RVT_1 PF00078.22 KII65098.1 - 1.6e-06 27.6 0.4 9.5e-06 25.1 0.1 2.2 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII65099.1 - 0.036 13.6 0.0 0.087 12.3 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain RRM_1 PF00076.17 KII65100.1 - 1.1e-32 111.4 0.0 7.9e-20 70.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII65100.1 - 4.3e-24 84.2 0.1 4.8e-15 55.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII65100.1 - 5.8e-15 54.8 0.0 2.9e-10 39.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII65100.1 - 0.018 14.8 0.4 0.072 12.9 0.1 1.9 2 0 0 2 2 2 0 RNA binding motif DDE_Tnp_IS1595 PF12762.2 KII65103.1 - 9e-18 64.5 0.0 1.1e-17 64.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII65103.1 - 0.0064 15.7 0.0 0.0083 15.3 0.0 1.2 1 0 0 1 1 1 1 Transposase IS66 family LCAT PF02450.10 KII65106.1 - 1e-43 149.8 0.6 1.2e-33 116.6 0.1 2.1 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 KII65106.1 - 4.5e-05 23.4 0.0 6.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 KII65106.1 - 0.00014 21.4 0.0 0.00039 20.0 0.0 1.7 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_5 PF12695.2 KII65106.1 - 0.0088 15.8 0.0 0.023 14.4 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF915 PF06028.6 KII65106.1 - 0.018 14.1 0.0 0.064 12.3 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.15 KII65106.1 - 0.13 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative esterase UQ_con PF00179.21 KII65108.1 - 0.00025 20.4 0.0 0.00035 20.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Popeye PF04831.8 KII65108.1 - 0.1 12.3 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Popeye protein conserved region TPR_12 PF13424.1 KII65109.1 - 1e-05 25.3 0.1 1.9e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII65109.1 - 0.0016 18.2 0.1 0.37 10.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat SecA_SW PF07516.8 KII65109.1 - 0.026 14.2 0.7 0.087 12.5 0.0 1.9 2 0 0 2 2 2 0 SecA Wing and Scaffold domain UQ_con PF00179.21 KII65110.1 - 6.7e-45 151.9 0.2 7.7e-45 151.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 KII65110.1 - 0.00015 21.4 0.1 0.00033 20.3 0.1 1.6 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.1 KII65110.1 - 0.0018 18.0 0.0 0.0022 17.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KII65110.1 - 0.054 13.3 0.3 0.075 12.9 0.2 1.5 1 1 0 1 1 1 0 RWD domain Viral_Beta_CD PF04530.7 KII65112.1 - 0.4 10.8 3.7 1.4 9.0 0.0 2.6 2 1 0 2 2 2 0 Viral Beta C/D like family Oxidored_q3 PF00499.15 KII65112.1 - 8.8 6.1 9.9 18 5.1 6.9 1.5 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 FAE1_CUT1_RppA PF08392.7 KII65114.1 - 0.023 13.7 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein Ldl_recept_a PF00057.13 KII65115.1 - 1.9e-19 69.2 35.9 2.5e-10 40.1 9.9 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF912 PF06024.7 KII65116.1 - 0.0036 17.3 0.1 0.0076 16.2 0.1 1.6 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) SHP PF03579.8 KII65116.1 - 0.034 13.4 2.5 0.14 11.5 0.5 2.5 2 0 0 2 2 2 0 Small hydrophobic protein ATP-synt_S1 PF05827.7 KII65116.1 - 0.2 10.9 0.0 0.2 10.9 0.0 1.6 2 0 0 2 2 2 0 Vacuolar ATP synthase subunit S1 (ATP6S1) Synaptobrevin PF00957.16 KII65116.1 - 0.41 10.2 3.7 0.83 9.2 2.6 1.5 1 0 0 1 1 1 0 Synaptobrevin CwfJ_C_1 PF04677.10 KII65120.1 - 8.3e-10 38.3 0.2 1.1e-09 37.9 0.2 1.1 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Hemopexin PF00045.14 KII65120.1 - 0.089 12.5 0.0 0.76 9.5 0.0 2.3 2 0 0 2 2 2 0 Hemopexin SNAP PF14938.1 KII65124.1 - 6.5e-16 58.3 3.6 9.3e-16 57.8 2.5 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII65124.1 - 6.7e-05 22.7 4.2 0.011 15.6 1.1 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII65124.1 - 0.0011 18.6 9.1 0.73 9.7 0.6 4.9 3 1 1 4 4 4 2 Tetratricopeptide repeat NSF PF02071.15 KII65124.1 - 0.22 12.1 4.3 29 5.8 0.1 4.6 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat MIT PF04212.13 KII65124.1 - 5.1 7.0 7.1 21 5.1 0.3 3.3 1 1 2 3 3 3 0 MIT (microtubule interacting and transport) domain DDE_3 PF13358.1 KII65125.1 - 3e-08 33.5 0.0 3.6e-08 33.2 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease FERM_N PF09379.5 KII65128.1 - 4.9e-06 26.5 0.1 2.6e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 FERM N-terminal domain PBP PF01161.15 KII65130.1 - 2.3e-10 40.5 0.0 2.6e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PBP PF01161.15 KII65131.1 - 3.3e-13 49.7 0.0 3.7e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF2358 PF10184.4 KII65134.1 - 0.095 12.6 0.2 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2358) GIY-YIG PF01541.19 KII65135.1 - 0.022 15.1 0.1 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 GIY-YIG catalytic domain DUF3904 PF13044.1 KII65135.1 - 0.067 11.6 0.0 0.08 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3904) zf-H2C2_2 PF13465.1 KII65136.1 - 0.0027 17.9 10.3 0.087 13.1 0.6 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 KII65136.1 - 0.013 15.6 4.2 0.12 12.5 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-DBF PF07535.7 KII65136.1 - 0.078 12.6 2.4 0.19 11.4 1.7 1.6 1 0 0 1 1 1 0 DBF zinc finger MS_channel PF00924.13 KII65136.1 - 0.079 12.2 0.3 0.13 11.6 0.2 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel zf-C2H2 PF00096.21 KII65136.1 - 0.13 12.6 11.2 0.14 12.5 0.8 2.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII65136.1 - 1.7 9.1 10.7 1.6 9.2 0.4 3.4 3 1 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_5 PF13909.1 KII65136.1 - 5.6 7.3 8.5 2.4 8.5 0.2 3.2 3 0 0 3 3 3 0 C2H2-type zinc-finger domain rve PF00665.21 KII65137.1 - 1.1e-07 32.0 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII65137.1 - 0.00039 19.7 0.1 0.00073 18.8 0.0 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Dynamin_N PF00350.18 KII65138.1 - 1.1e-46 158.6 0.1 1.9e-46 157.9 0.1 1.3 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 KII65138.1 - 7.9e-46 156.1 0.1 1.1e-45 155.6 0.1 1.2 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.18 KII65138.1 - 0.0016 18.3 0.0 0.0056 16.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KII65138.1 - 0.0029 18.0 0.0 0.0073 16.7 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 KII65138.1 - 0.082 12.2 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 Ras family AAA_16 PF13191.1 KII65138.1 - 0.1 12.5 0.0 0.84 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain GED PF02212.13 KII65139.1 - 1.9e-11 43.7 3.1 2.4e-11 43.3 2.2 1.1 1 0 0 1 1 1 1 Dynamin GTPase effector domain DUF605 PF04652.11 KII65139.1 - 7.8 5.7 15.1 9 5.5 10.5 1.1 1 0 0 1 1 1 0 Vta1 like DDE_Tnp_IS1595 PF12762.2 KII65140.1 - 0.0037 17.0 0.0 0.0054 16.5 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain ABC2_membrane_3 PF12698.2 KII65141.1 - 3.8 6.4 7.0 4.1 6.3 4.9 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1096 PF06493.6 KII65144.1 - 4.7 7.2 6.1 3.5 7.6 1.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1096) Spc7 PF08317.6 KII65145.1 - 0.0024 16.5 2.8 0.003 16.2 2.0 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein FliJ PF02050.11 KII65145.1 - 0.067 13.2 2.6 0.16 11.9 1.8 1.6 1 1 0 1 1 1 0 Flagellar FliJ protein Methyltransf_PK PF05891.7 KII65145.1 - 0.072 12.3 0.0 0.096 11.9 0.0 1.1 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Salp15 PF12115.3 KII65145.1 - 0.1 12.8 0.0 0.13 12.4 0.0 1.3 1 1 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation L_lactis_ph-MCP PF06673.6 KII65145.1 - 0.28 9.8 2.8 0.36 9.5 1.9 1.1 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein TPR_MLP1_2 PF07926.7 KII65145.1 - 1.1 9.0 6.7 2 8.1 4.7 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1043 PF06295.7 KII65145.1 - 1.7 8.3 8.9 9.4 5.8 0.3 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1043) DUF4200 PF13863.1 KII65145.1 - 1.9 8.4 9.4 1.6 8.6 3.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Erp_C PF06780.6 KII65145.1 - 2.8 7.7 6.2 3.7 7.3 4.3 1.1 1 0 0 1 1 1 0 Erp protein C-terminus UPF0449 PF15136.1 KII65145.1 - 8.1 6.7 6.1 3.6 7.8 2.0 1.9 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 RE_HindVP PF09519.5 KII65146.1 - 0.1 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 HindVP restriction endonuclease DUF3333 PF11812.3 KII65146.1 - 0.29 11.1 7.2 8.2 6.4 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3333) Adeno_E3A PF05248.7 KII65147.1 - 0.056 13.4 1.0 0.25 11.3 0.7 1.9 1 1 1 2 2 2 0 Adenovirus E3A IMS PF00817.15 KII65153.1 - 1.9e-40 138.0 0.0 7.5e-40 136.1 0.0 2.0 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.3 KII65153.1 - 1.4e-16 60.5 0.5 3.4e-16 59.3 0.3 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 KII65153.1 - 0.0033 17.3 0.0 0.0093 15.9 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif DUF4423 PF14394.1 KII65156.1 - 0.13 11.7 0.3 5.8 6.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) Gene66 PF02053.10 KII65158.1 - 0.05 13.0 0.1 0.057 12.8 0.1 1.1 1 0 0 1 1 1 0 Gene 66 (IR5) protein rve PF00665.21 KII65161.1 - 2.5e-08 34.0 0.1 5.7e-08 32.8 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65161.1 - 2.3e-05 23.8 0.2 5.3e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain zf-UBR PF02207.15 KII65162.1 - 3.7e-12 45.7 11.2 3.7e-12 45.7 7.8 2.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-UBR PF02207.15 KII65163.1 - 7.9e-08 31.9 5.5 7.9e-08 31.9 3.8 1.6 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-RVT PF13966.1 KII65166.1 - 0.043 14.1 0.1 0.053 13.8 0.1 1.3 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase COQ7 PF03232.8 KII65167.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 DUF768 PF05589.6 KII65168.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF768) Gtr1_RagA PF04670.7 KII65170.1 - 0.016 14.3 1.1 0.03 13.4 0.7 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DDE_3 PF13358.1 KII65173.1 - 0.087 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease PHB_acc_N PF07879.6 KII65174.1 - 0.074 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 PHB/PHA accumulation regulator DNA-binding domain DDE_3 PF13358.1 KII65176.1 - 1.2e-13 51.0 0.0 1.5e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII65178.1 - 0.0083 16.2 0.1 0.033 14.3 0.0 2.0 1 1 1 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.1 KII65178.1 - 0.094 13.5 0.1 0.19 12.5 0.1 1.7 1 1 0 1 1 1 0 Homeodomain-like domain DUF3873 PF12989.2 KII65178.1 - 0.098 12.7 0.1 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) DUF1359 PF07097.6 KII65178.1 - 0.15 12.0 1.3 1.5 8.8 0.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1359) DUF1064 PF06356.6 KII65179.1 - 0.052 13.5 4.1 0.035 14.1 1.0 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1064) DUF1380 PF07128.7 KII65179.1 - 0.089 12.6 0.2 0.13 12.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1380) AAA_23 PF13476.1 KII65179.1 - 5 7.3 17.6 6.8 6.9 12.2 1.2 1 0 0 1 1 1 0 AAA domain DUF2356 PF10189.4 KII65181.1 - 4.8e-36 123.9 0.3 6e-36 123.6 0.2 1.2 1 0 0 1 1 1 1 Conserved protein (DUF2356) Sugar-bind PF04198.8 KII65183.1 - 0.14 11.0 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Putative sugar-binding domain SNAP PF14938.1 KII65186.1 - 1.2e-08 34.4 0.3 1.4e-08 34.2 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP rve PF00665.21 KII65187.1 - 1.2e-06 28.6 0.1 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Baculo_gp41 PF04700.7 KII65187.1 - 0.14 11.5 1.1 0.25 10.7 0.8 1.4 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region Dimer_Tnp_hAT PF05699.9 KII65188.1 - 6.5e-08 32.0 0.0 8.4e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Serpin PF00079.15 KII65191.1 - 4e-36 124.9 4.3 4.8e-36 124.6 3.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII65192.1 - 1.5e-42 146.0 3.1 1.6e-42 145.9 2.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII65193.1 - 4.8e-22 78.6 0.6 5.1e-22 78.5 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII65194.1 - 1.6e-13 50.5 0.1 1.7e-13 50.4 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AIG1 PF04548.11 KII65194.1 - 0.14 11.2 0.4 1.6 7.7 0.0 2.0 1 1 1 2 2 2 0 AIG1 family Serpin PF00079.15 KII65195.1 - 5.6e-59 200.1 6.0 6.3e-59 199.9 4.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DNA_primase_S PF01896.14 KII65197.1 - 0.042 13.6 0.7 4.5 7.0 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase small subunit THF_DHG_CYH_C PF02882.14 KII65202.1 - 0.0061 15.6 0.0 0.0069 15.4 0.0 1.1 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain LRRC37AB_C PF14914.1 KII65204.1 - 0.068 12.5 0.0 0.08 12.3 0.0 1.1 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain HTH_Tnp_Tc5 PF03221.11 KII65204.1 - 0.12 12.1 0.3 0.23 11.2 0.2 1.6 1 1 0 1 1 1 0 Tc5 transposase DNA-binding domain CFEM PF05730.6 KII65206.1 - 0.16 11.7 1.8 0.26 11.1 1.2 1.6 1 1 0 1 1 1 0 CFEM domain SHS2_Rpb7-N PF03876.12 KII65209.1 - 5.5e-15 55.2 0.1 1.5e-14 53.8 0.0 1.8 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 KII65209.1 - 7.2e-11 42.0 0.0 1.1e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.7 KII65209.1 - 0.0029 17.7 0.0 0.0043 17.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Vps8 PF12816.2 KII65211.1 - 3.2e-14 52.6 3.9 2.4e-10 39.9 0.5 2.5 1 1 1 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 BTB_2 PF02214.17 KII65211.1 - 0.076 13.2 0.4 0.35 11.1 0.1 2.2 1 1 2 3 3 3 0 BTB/POZ domain PurA PF04845.8 KII65212.1 - 1.3e-12 47.3 0.2 8e-05 21.8 0.0 3.0 2 1 1 3 3 3 3 PurA ssDNA and RNA-binding protein Nop16 PF09420.5 KII65215.1 - 3.8e-08 33.5 6.6 7.7e-08 32.6 0.0 2.1 2 0 0 2 2 2 1 Ribosome biogenesis protein Nop16 DUF3997 PF13162.1 KII65217.1 - 0.0049 16.6 0.2 0.011 15.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3997) API5 PF05918.6 KII65218.1 - 1.2e-39 136.2 0.1 1.7e-39 135.7 0.1 1.2 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.1 KII65218.1 - 0.0032 17.7 0.0 0.0085 16.3 0.0 1.7 1 0 0 1 1 1 1 HEAT repeats HEAT PF02985.17 KII65218.1 - 0.0039 17.1 0.9 0.014 15.4 0.0 2.5 3 0 0 3 3 3 1 HEAT repeat HIT PF01230.18 KII65221.1 - 5.6e-05 23.5 0.1 0.00011 22.6 0.0 1.4 1 0 0 1 1 1 1 HIT domain CENP-B_N PF04218.8 KII65225.1 - 0.00036 19.8 0.0 0.0011 18.3 0.0 1.8 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_3 PF13358.1 KII65226.1 - 8.1e-21 74.3 0.0 1e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RRM_1 PF00076.17 KII65227.1 - 1.2e-16 60.1 0.1 9e-10 38.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII65227.1 - 1.9e-09 37.3 0.0 1.9e-06 27.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII65227.1 - 3.1e-06 26.9 0.2 0.0028 17.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII65227.1 - 0.0016 18.2 0.0 0.29 10.9 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif Limkain-b1 PF11608.3 KII65227.1 - 0.018 14.7 0.1 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Limkain b1 SinI PF08671.5 KII65227.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Anti-repressor SinI Med18 PF09637.5 KII65228.1 - 0.00053 19.5 0.0 0.027 14.0 0.0 2.0 1 1 0 2 2 2 2 Med18 protein TNF PF00229.13 KII65229.1 - 0.037 13.5 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family MMR_HSR1 PF01926.18 KII65231.1 - 4.8e-07 29.7 0.0 0.00011 22.1 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KII65231.1 - 0.0018 17.6 0.5 2 7.6 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.22 KII65231.1 - 0.0089 15.4 0.1 2.9 7.2 0.0 2.5 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain zf-CCHC_4 PF14392.1 KII65231.1 - 0.012 15.2 0.3 0.036 13.7 0.2 1.8 1 0 0 1 1 1 0 Zinc knuckle DUF258 PF03193.11 KII65231.1 - 0.017 14.3 0.0 0.032 13.4 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF258 G-alpha PF00503.15 KII65231.1 - 0.032 12.9 2.6 0.66 8.5 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_29 PF13555.1 KII65231.1 - 0.12 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain rve PF00665.21 KII65233.1 - 4.5e-19 68.7 0.0 8.4e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65233.1 - 0.00045 19.6 0.3 0.0042 16.5 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII65233.1 - 0.0084 16.0 0.1 0.0084 16.0 0.1 1.9 2 1 0 2 2 2 1 DDE domain Abhydrolase_5 PF12695.2 KII65234.1 - 2.8e-13 49.8 0.0 3.7e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KII65234.1 - 3.9e-07 30.1 0.0 5e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF818 PF05677.7 KII65234.1 - 0.00041 19.1 0.1 0.00053 18.8 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_1 PF00561.15 KII65234.1 - 0.0099 15.4 0.1 0.014 15.0 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.7 KII65234.1 - 0.013 14.3 0.1 0.017 13.9 0.1 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_3 PF07859.8 KII65234.1 - 0.048 13.2 0.2 0.083 12.4 0.1 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.15 KII65234.1 - 0.12 11.7 0.1 0.17 11.2 0.1 1.1 1 0 0 1 1 1 0 Putative esterase RhoGAP PF00620.22 KII65235.1 - 1.3e-08 34.6 0.0 2.9e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain Pkinase PF00069.20 KII65236.1 - 2.1e-72 243.3 0.0 2.9e-72 242.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII65236.1 - 4.8e-35 120.8 0.0 7.1e-35 120.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII65236.1 - 1.1e-05 24.5 0.0 0.0007 18.6 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 KII65236.1 - 0.00018 20.6 0.1 0.00032 19.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KII65236.1 - 0.0042 16.8 0.0 1.7 8.3 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family DDE_3 PF13358.1 KII65239.1 - 2.1e-18 66.4 0.0 5.1e-18 65.2 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease Arg_repressor PF01316.16 KII65239.1 - 3.5e-07 29.6 2.0 4e-07 29.5 0.1 2.1 2 0 0 2 2 2 1 Arginine repressor, DNA binding domain DDE_1 PF03184.14 KII65239.1 - 2e-05 23.8 0.0 4.4e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_38 PF13936.1 KII65239.1 - 3.4e-05 23.2 0.3 0.0072 15.8 0.0 2.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII65239.1 - 0.014 15.4 3.4 0.029 14.4 0.2 2.8 2 0 0 2 2 2 0 Transposase PspA_IM30 PF04012.7 KII65239.1 - 0.038 13.3 0.1 7.1 5.9 0.0 2.2 2 0 0 2 2 2 0 PspA/IM30 family HTH_33 PF13592.1 KII65239.1 - 0.099 12.1 0.0 0.26 10.8 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix TRAPP PF04051.11 KII65240.1 - 7.8e-16 57.9 0.0 1.5e-15 57.0 0.0 1.4 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component efThoc1 PF11957.3 KII65241.1 - 1.5e-19 69.9 1.7 1.8e-19 69.6 1.2 1.0 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Kelch_6 PF13964.1 KII65244.1 - 1.2e-24 85.3 11.4 1e-06 28.6 0.1 6.1 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII65244.1 - 1e-14 53.7 9.6 4.4e-05 22.9 0.1 6.3 6 1 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 KII65244.1 - 7e-10 38.8 5.2 0.16 12.1 0.0 6.4 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII65244.1 - 3.1e-09 36.5 2.0 0.01 15.7 0.0 4.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 KII65244.1 - 6.8e-08 31.9 7.1 0.039 13.7 0.1 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.1 KII65244.1 - 9.5e-08 31.6 10.8 0.016 14.9 0.0 5.9 6 1 0 6 6 6 2 Galactose oxidase, central domain Serpin PF00079.15 KII65249.1 - 1.1e-22 80.7 0.5 1.3e-22 80.5 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.21 KII65250.1 - 5.1e-25 87.9 0.0 8.1e-25 87.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65250.1 - 0.0012 18.3 0.0 0.0034 16.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DUF1411 PF07199.6 KII65251.1 - 0.078 12.4 0.5 0.11 11.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) Peptidase_M3 PF01432.15 KII65253.1 - 9.7e-53 179.8 0.9 1.4e-52 179.2 0.6 1.1 1 0 0 1 1 1 1 Peptidase family M3 Beach PF02138.13 KII65254.1 - 0.00046 19.7 0.0 0.00082 18.8 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain Arch_fla_DE PF04659.8 KII65254.1 - 0.033 13.9 0.0 0.059 13.1 0.0 1.4 1 0 0 1 1 1 0 Archaeal flagella protein MIG-14_Wnt-bd PF06664.7 KII65254.1 - 0.062 12.1 0.6 0.08 11.7 0.4 1.1 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion zf-UBR PF02207.15 KII65255.1 - 2e-12 46.6 14.4 5e-12 45.3 10.0 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) FBD PF08387.5 KII65255.1 - 0.07 12.6 0.3 0.07 12.6 0.2 3.0 3 0 0 3 3 3 0 FBD EMP24_GP25L PF01105.19 KII65261.1 - 3.1e-12 46.5 1.1 6.8e-06 25.9 0.2 2.0 2 0 0 2 2 2 2 emp24/gp25L/p24 family/GOLD SNAP PF14938.1 KII65263.1 - 6.2e-07 28.8 0.2 7.9e-07 28.5 0.1 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF2087 PF09860.4 KII65263.1 - 0.0093 15.6 0.2 0.08 12.7 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2087) OSTMP1 PF09777.4 KII65263.1 - 0.029 13.5 0.9 0.046 12.8 0.6 1.3 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor MRG PF05712.8 KII65263.1 - 0.065 12.1 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 MRG RVT_1 PF00078.22 KII65266.1 - 1.6e-16 60.3 0.1 3.4e-16 59.2 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PTN_MK_C PF01091.13 KII65267.1 - 0.018 15.0 0.9 0.037 13.9 0.0 1.8 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, C-terminal domain PPO1_KFDV PF12143.3 KII65267.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF_B2219) Spc97_Spc98 PF04130.8 KII65270.1 - 8.4e-16 57.3 0.0 7.1e-15 54.3 0.0 1.8 1 1 1 2 2 2 2 Spc97 / Spc98 family HLH PF00010.21 KII65271.1 - 0.059 13.0 0.1 0.098 12.3 0.1 1.3 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Proteasome PF00227.21 KII65275.1 - 4.7e-46 156.4 1.6 5.8e-46 156.1 1.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Dimer_Tnp_hAT PF05699.9 KII65276.1 - 6e-16 57.8 0.4 8.1e-16 57.4 0.3 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Mitochondr_Som1 PF11093.3 KII65276.1 - 0.056 13.2 0.1 0.076 12.8 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial export protein Som1 PLDc_2 PF13091.1 KII65277.1 - 1.6e-15 56.9 2.2 2.9e-08 33.5 0.6 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc_3 PF13918.1 KII65277.1 - 0.00097 18.6 0.3 0.54 9.6 0.0 2.6 2 1 0 2 2 2 2 PLD-like domain Regulator_TrmB PF11495.3 KII65277.1 - 0.058 12.3 0.8 3.3 6.6 0.1 2.3 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB Cullin PF00888.17 KII65278.1 - 7.1e-10 38.0 0.0 9.1e-10 37.6 0.0 1.1 1 0 0 1 1 1 1 Cullin family RasGEF_N PF00618.15 KII65278.1 - 0.019 15.0 0.0 0.17 11.9 0.0 2.0 1 1 1 2 2 2 0 RasGEF N-terminal motif LcrV PF04792.7 KII65278.1 - 0.033 13.2 0.0 0.069 12.1 0.0 1.4 1 1 0 1 1 1 0 V antigen (LcrV) protein Cullin PF00888.17 KII65279.1 - 8.2e-15 54.3 0.0 9.3e-15 54.1 0.0 1.0 1 0 0 1 1 1 1 Cullin family DUF4340 PF14238.1 KII65281.1 - 0.022 14.4 0.3 0.03 14.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4340) Hint PF01079.15 KII65281.1 - 0.1 11.7 0.2 0.24 10.5 0.0 1.6 2 0 0 2 2 2 0 Hint module TaqI_C PF12950.2 KII65283.1 - 0.0033 17.1 0.1 0.0041 16.8 0.1 1.2 1 0 0 1 1 1 1 TaqI-like C-terminal specificity domain Borrelia_orfX PF04160.7 KII65283.1 - 0.023 14.4 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Orf-X protein Stn1 PF10451.4 KII65283.1 - 0.062 12.1 0.1 0.079 11.7 0.1 1.1 1 0 0 1 1 1 0 Telomere regulation protein Stn1 Ubiq_cyt_C_chap PF03981.7 KII65286.1 - 0.16 11.8 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone ORF6C PF10552.4 KII65288.1 - 0.091 12.4 0.1 4.4 7.0 0.0 2.4 2 0 0 2 2 2 0 ORF6C domain DDE_3 PF13358.1 KII65289.1 - 1.3e-11 44.4 0.0 1.6e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.1 KII65291.1 - 1.3e-11 44.1 0.9 3e-11 43.0 0.7 1.5 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.4 KII65291.1 - 6.6e-05 22.3 0.5 0.0003 20.2 0.3 1.9 1 1 1 2 2 2 1 26S proteasome subunit RPN7 NSF PF02071.15 KII65291.1 - 0.01 16.2 1.1 0.94 10.3 0.0 3.6 3 0 0 3 3 3 1 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.12 KII65291.1 - 0.049 13.5 0.5 7.2 6.8 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF473 PF04322.7 KII65291.1 - 0.091 12.3 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF473) TPR_1 PF00515.23 KII65291.1 - 0.24 11.0 1.5 11 5.8 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Serpin PF00079.15 KII65293.1 - 1e-20 74.2 1.7 1.1e-20 74.0 1.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.1 KII65294.1 - 3.4e-19 69.0 0.2 4.4e-19 68.6 0.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.4 KII65294.1 - 0.0086 15.4 0.1 0.056 12.8 0.0 2.4 1 1 0 2 2 2 1 26S proteasome subunit RPN7 TPR_11 PF13414.1 KII65294.1 - 0.024 14.2 4.0 0.92 9.2 0.6 4.0 3 2 1 4 4 4 0 TPR repeat Sigma70_r1_1 PF03979.9 KII65294.1 - 0.029 14.2 0.1 0.065 13.1 0.1 1.6 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 DUF2192 PF09958.4 KII65294.1 - 0.068 12.3 0.1 0.13 11.4 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2192) TPR_2 PF07719.12 KII65294.1 - 0.072 13.0 3.9 0.52 10.3 0.3 3.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII65294.1 - 0.29 11.0 2.0 2.2 8.2 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII65294.1 - 2.1 8.0 6.4 4.3 7.1 0.6 4.2 5 1 0 5 5 5 0 Tetratricopeptide repeat SNAP PF14938.1 KII65295.1 - 1.3e-07 31.0 0.2 1.5e-07 30.8 0.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII65295.1 - 0.0019 17.9 0.1 0.21 11.5 0.0 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII65295.1 - 0.0063 16.0 0.0 0.61 9.7 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII65295.1 - 0.018 14.6 0.0 0.1 12.2 0.0 2.2 2 0 0 2 2 2 0 TPR repeat DUF310 PF03750.8 KII65295.1 - 0.032 14.4 0.3 0.15 12.2 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF310) Sigma70_r1_1 PF03979.9 KII65295.1 - 0.066 13.1 0.1 0.17 11.8 0.1 1.7 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 DDE_3 PF13358.1 KII65296.1 - 2.1e-08 34.0 0.1 3.1e-08 33.4 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF2315 PF10231.4 KII65297.1 - 0.0043 16.9 0.2 0.0051 16.6 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2315) Btz PF09405.5 KII65297.1 - 0.049 13.6 0.6 0.06 13.3 0.4 1.1 1 0 0 1 1 1 0 CASC3/Barentsz eIF4AIII binding zf-CCHC PF00098.18 KII65298.1 - 0.00019 21.2 8.1 0.0041 16.9 1.0 2.5 2 0 0 2 2 2 2 Zinc knuckle DRP PF06044.7 KII65298.1 - 0.016 14.1 1.2 0.016 14.1 0.8 1.6 2 0 0 2 2 2 0 Dam-replacing family Mo-nitro_C PF06967.6 KII65299.1 - 0.024 14.7 0.1 0.047 13.8 0.1 1.5 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus rve PF00665.21 KII65300.1 - 6.5e-27 94.0 0.0 7.8e-27 93.7 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65300.1 - 3.8e-05 23.1 0.1 6.2e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve PF00665.21 KII65303.1 - 1.3e-05 25.2 0.0 4.3e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65303.1 - 0.00013 21.3 0.0 0.00033 20.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF1319 PF07028.6 KII65304.1 - 0.0017 18.5 0.4 0.0023 18.1 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1319) RVT_1 PF00078.22 KII65304.1 - 0.0018 17.6 0.1 0.0024 17.2 0.1 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_DsbA PF11126.3 KII65304.1 - 0.11 12.6 0.4 0.34 11.0 0.2 2.0 1 1 0 1 1 1 0 Transcriptional regulator DsbA rve PF00665.21 KII65305.1 - 3.2e-09 36.9 0.0 8.9e-09 35.4 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain DUF1092 PF06485.6 KII65305.1 - 0.018 13.9 0.3 0.027 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1092) 2C_adapt PF08793.5 KII65305.1 - 1 9.3 3.7 6 6.8 0.0 3.6 4 0 0 4 4 4 0 2-cysteine adaptor domain DUF2274 PF10038.4 KII65307.1 - 0.048 13.7 0.1 0.09 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) Spuma_A9PTase PF03539.9 KII65308.1 - 0.084 12.7 0.1 0.8 9.6 0.0 2.0 1 1 1 2 2 2 0 Spumavirus aspartic protease (A9) rve PF00665.21 KII65310.1 - 2.1e-14 53.6 0.0 2.6e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65310.1 - 0.003 17.0 0.0 0.02 14.4 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.18 KII65311.1 - 0.029 14.2 3.2 0.054 13.4 2.2 1.5 1 0 0 1 1 1 0 Zinc knuckle Asp_protease_2 PF13650.1 KII65311.1 - 0.038 14.4 0.0 0.064 13.7 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII65311.1 - 0.054 13.3 0.0 0.092 12.5 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII65311.1 - 0.059 13.0 1.0 0.12 12.0 0.7 1.5 1 0 0 1 1 1 0 Zinc knuckle VanY PF02557.12 KII65311.1 - 0.17 11.7 0.4 1.3 8.8 0.0 2.1 1 1 1 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Sec5 PF15469.1 KII65314.1 - 0.0025 17.5 0.3 0.57 9.8 0.1 2.0 1 1 1 2 2 2 2 Exocyst complex component Sec5 rve PF00665.21 KII65314.1 - 0.013 15.6 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain DUF2706 PF10913.3 KII65315.1 - 0.052 13.1 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) MULE PF10551.4 KII65317.1 - 0.00086 19.4 0.2 0.0028 17.7 0.1 1.9 2 0 0 2 2 2 1 MULE transposase domain RVP PF00077.15 KII65319.1 - 2.1e-07 30.7 0.1 5e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII65319.1 - 1.2e-05 25.7 0.1 2.4e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII65319.1 - 0.00017 21.3 5.4 0.00036 20.3 3.7 1.6 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.1 KII65319.1 - 0.00061 19.5 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII65319.1 - 0.012 15.2 2.2 0.027 14.1 1.5 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_3 PF13917.1 KII65319.1 - 0.045 13.5 0.2 0.088 12.5 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle Asp_protease PF09668.5 KII65319.1 - 0.058 12.9 0.1 0.14 11.7 0.1 1.6 1 0 0 1 1 1 0 Aspartyl protease Spuma_A9PTase PF03539.9 KII65319.1 - 0.063 13.1 0.1 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) HSBP1 PF06825.7 KII65319.1 - 0.2 11.2 2.3 0.52 9.9 0.0 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Pox_A_type_inc PF04508.7 KII65319.1 - 0.57 10.1 3.0 0.57 10.1 0.4 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat rve PF00665.21 KII65320.1 - 1.7e-22 79.7 0.0 1.2e-21 77.0 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.5 KII65320.1 - 8.2e-05 21.9 0.0 0.00024 20.4 0.0 1.9 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII65320.1 - 0.00094 18.6 0.0 0.003 17.0 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain MMR_HSR1 PF01926.18 KII65322.1 - 2.1e-19 69.5 0.1 3.7e-15 55.8 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase GN3L_Grn1 PF08701.6 KII65322.1 - 2.2e-12 46.6 13.8 2.2e-12 46.6 9.6 2.3 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase FeoB_N PF02421.13 KII65322.1 - 7.5e-10 38.2 0.7 4.7e-08 32.4 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KII65322.1 - 0.00023 21.0 0.8 0.00023 21.0 0.6 3.4 3 2 0 3 3 3 1 Dynamin family DUF258 PF03193.11 KII65322.1 - 0.0013 17.9 0.4 0.0031 16.7 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Gtr1_RagA PF04670.7 KII65322.1 - 0.009 15.1 0.0 0.022 13.8 0.0 1.7 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KII65322.1 - 0.01 15.2 0.2 0.32 10.3 0.0 2.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AIG1 PF04548.11 KII65322.1 - 0.013 14.6 1.2 0.026 13.6 0.8 1.5 1 0 0 1 1 1 0 AIG1 family Arf PF00025.16 KII65322.1 - 0.018 14.2 0.2 1.1 8.5 0.0 2.5 1 1 1 2 2 2 0 ADP-ribosylation factor family ArgK PF03308.11 KII65322.1 - 0.023 13.4 0.1 0.042 12.6 0.0 1.3 1 0 0 1 1 1 0 ArgK protein cobW PF02492.14 KII65322.1 - 0.028 13.8 0.1 0.24 10.8 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Miro PF08477.8 KII65322.1 - 0.078 13.4 0.2 0.9 10.0 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein GIY-YIG PF01541.19 KII65322.1 - 0.11 12.8 3.9 14 6.1 0.0 2.7 2 0 0 2 2 2 0 GIY-YIG catalytic domain RRM_1 PF00076.17 KII65323.1 - 9.4e-28 95.6 1.8 1.2e-18 66.4 0.0 3.4 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII65323.1 - 1.4e-18 66.5 0.1 1.2e-10 41.2 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII65323.1 - 2.8e-15 55.9 0.2 1.5e-06 27.9 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII65323.1 - 1.5e-08 34.2 0.1 0.00018 21.2 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 KII65323.1 - 3.6e-05 23.4 1.5 0.0046 16.6 0.9 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF1041 PF06292.12 KII65323.1 - 0.061 13.5 0.1 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1041) HTH_Tnp_Tc3_2 PF01498.13 KII65324.1 - 0.026 14.5 1.3 0.049 13.6 0.9 1.6 1 0 0 1 1 1 0 Transposase HTH_Tnp_Tc3_1 PF11427.3 KII65324.1 - 0.04 13.5 0.1 0.16 11.6 0.0 1.9 1 1 1 2 2 2 0 Tc3 transposase Cut8_N PF14482.1 KII65324.1 - 0.26 11.3 0.0 0.26 11.3 0.0 2.2 3 0 0 3 3 3 0 Cut8 proteasome-binding domain Vasohibin PF14822.1 KII65325.1 - 0.016 14.2 0.0 0.025 13.6 0.0 1.3 1 0 0 1 1 1 0 Vasohibin DDE_3 PF13358.1 KII65326.1 - 1e-07 31.8 0.0 1.3e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_S8 PF00082.17 KII65327.1 - 7.7e-31 107.2 0.0 1.1e-30 106.7 0.0 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 KII65327.1 - 8.6e-14 51.0 0.3 2e-13 49.8 0.0 1.8 2 0 0 2 2 2 1 Proprotein convertase P-domain Flavoprotein PF02441.14 KII65328.1 - 2.7e-28 98.2 0.1 7.1e-28 96.8 0.1 1.6 1 1 0 1 1 1 1 Flavoprotein TAXi_C PF14541.1 KII65328.1 - 0.0071 15.9 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Fe-S_biosyn PF01521.15 KII65329.1 - 2.5e-14 53.1 0.1 2.8e-14 52.9 0.1 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis RVT_1 PF00078.22 KII65330.1 - 2.4e-25 89.1 0.2 8.9e-25 87.2 0.3 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII65330.1 - 2.1e-22 79.4 0.0 4.9e-22 78.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII65330.1 - 5.7e-08 32.5 0.0 8e-07 28.9 0.0 2.4 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII65330.1 - 5.2e-05 22.9 3.2 0.00014 21.6 2.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII65330.1 - 0.00024 21.5 0.1 0.0013 19.1 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease rve_3 PF13683.1 KII65330.1 - 0.0047 16.4 0.1 0.063 12.8 0.0 2.9 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.9 KII65330.1 - 0.02 14.7 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII65330.1 - 0.035 13.9 0.0 0.09 12.6 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Reprolysin_2 PF13574.1 KII65331.1 - 2.2e-14 53.9 0.0 3.7e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 KII65331.1 - 1.1e-12 48.3 0.0 1.7e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 KII65331.1 - 2.2e-09 37.1 0.0 3.5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 KII65331.1 - 3.2e-05 24.4 0.0 6.4e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.14 KII65331.1 - 0.00055 19.5 0.8 0.0015 18.1 0.6 1.6 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease RPN7 PF10602.4 KII65331.1 - 0.044 13.1 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Peptidase_M10 PF00413.19 KII65331.1 - 0.081 12.6 0.1 0.12 12.1 0.0 1.6 1 1 0 1 1 1 0 Matrixin Ras PF00071.17 KII65332.1 - 5.4e-59 198.2 0.3 6.6e-59 197.9 0.2 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII65332.1 - 9.6e-22 77.7 0.0 1.6e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII65332.1 - 1.1e-12 47.5 0.1 1.3e-12 47.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KII65332.1 - 3e-09 36.3 0.1 3.4e-09 36.1 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KII65332.1 - 9.4e-07 28.4 0.0 1.2e-05 24.8 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 KII65332.1 - 4.2e-05 22.8 0.0 5.7e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 KII65332.1 - 4.7e-05 23.3 0.0 7.5e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KII65332.1 - 0.0057 16.5 0.1 0.9 9.3 0.0 2.5 2 1 1 3 3 3 1 Dynamin family AAA_14 PF13173.1 KII65332.1 - 0.0064 16.3 0.1 0.011 15.5 0.1 1.4 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 KII65332.1 - 0.014 15.1 0.1 0.023 14.4 0.0 1.3 2 0 0 2 2 2 0 Archaeal ATPase FeoB_N PF02421.13 KII65332.1 - 0.017 14.4 0.0 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B G-alpha PF00503.15 KII65332.1 - 0.067 11.8 0.8 1.5 7.4 0.1 2.6 1 1 1 2 2 2 0 G-protein alpha subunit V-ATPase_H_N PF03224.9 KII65333.1 - 0.045 12.8 0.9 0.053 12.6 0.6 1.0 1 0 0 1 1 1 0 V-ATPase subunit H EcoRI PF02963.11 KII65333.1 - 0.1 11.3 0.1 0.11 11.2 0.1 1.1 1 0 0 1 1 1 0 Restriction endonuclease EcoRI DDE_Tnp_IS1595 PF12762.2 KII65334.1 - 2.9e-12 46.6 0.1 8.9e-12 45.0 0.0 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain RRM_1 PF00076.17 KII65335.1 - 1.1e-35 121.0 0.0 5.3e-19 67.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII65335.1 - 3.4e-30 103.8 0.0 9.1e-14 51.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII65335.1 - 2.8e-13 49.5 0.0 2.1e-05 24.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII65335.1 - 0.00013 21.6 0.1 0.66 9.7 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif FtsX PF02687.16 KII65338.1 - 0.016 14.9 0.5 0.027 14.2 0.3 1.4 1 0 0 1 1 1 0 FtsX-like permease family HNH PF01844.18 KII65338.1 - 0.098 12.5 0.1 0.23 11.3 0.1 1.6 1 1 0 1 1 1 0 HNH endonuclease WD40 PF00400.27 KII65340.1 - 1.8e-22 78.3 4.6 2e-08 33.7 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat eIF2A PF08662.6 KII65340.1 - 1.2e-05 25.1 0.0 0.16 11.6 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A DUF2258 PF10015.4 KII65343.1 - 0.11 12.2 0.4 0.45 10.3 0.1 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) PocR PF10114.4 KII65344.1 - 0.092 11.8 0.1 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Sensory domain found in PocR CCDC155 PF14662.1 KII65346.1 - 0.0064 16.1 7.4 0.0085 15.7 5.1 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 V-SNARE PF05008.10 KII65346.1 - 0.022 14.9 3.2 0.22 11.7 0.1 2.5 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus SLX9 PF15341.1 KII65346.1 - 0.04 14.3 1.7 0.055 13.9 1.2 1.3 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 CALCOCO1 PF07888.6 KII65346.1 - 0.093 10.9 9.6 0.099 10.9 1.5 1.9 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Myosin_HC-like PF07058.6 KII65346.1 - 0.76 8.8 6.9 0.085 11.9 1.2 1.8 2 1 0 2 2 2 0 Myosin II heavy chain-like DUF972 PF06156.8 KII65346.1 - 0.81 10.0 7.1 0.6 10.4 0.7 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF972) Lge1 PF11488.3 KII65346.1 - 1.8 8.8 5.3 0.91 9.7 0.1 2.4 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 CCDC-167 PF15188.1 KII65346.1 - 4.5 7.2 8.4 1.8 8.5 2.0 2.4 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 IncA PF04156.9 KII65346.1 - 8.7 5.8 14.2 0.99 8.9 0.8 2.3 1 1 0 2 2 2 0 IncA protein SYCE1 PF15233.1 KII65347.1 - 0.0015 18.4 5.7 0.019 14.9 1.9 2.1 1 1 1 2 2 2 1 Synaptonemal complex central element protein 1 Nsp1_C PF05064.8 KII65347.1 - 0.0083 15.7 0.9 0.0083 15.7 0.6 1.5 2 0 0 2 2 2 1 Nsp1-like C-terminal region Sec8_exocyst PF04048.9 KII65347.1 - 0.018 14.6 1.3 0.027 14.0 0.9 1.4 1 1 0 1 1 1 0 Sec8 exocyst complex component specific domain Snapin_Pallidin PF14712.1 KII65347.1 - 0.037 14.3 3.6 0.063 13.6 1.4 1.9 1 1 1 2 2 2 0 Snapin/Pallidin eIF3_N PF09440.5 KII65347.1 - 0.063 13.4 3.6 0.08 13.1 2.5 1.1 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain Rabaptin PF03528.10 KII65347.1 - 0.086 12.7 4.8 1.7 8.5 0.2 2.2 2 0 0 2 2 2 0 Rabaptin DUF4164 PF13747.1 KII65347.1 - 0.096 12.8 1.0 0.16 12.0 0.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) SH3BP5 PF05276.9 KII65347.1 - 0.15 11.3 5.0 0.05 12.9 1.4 1.6 1 1 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) GrpE PF01025.14 KII65347.1 - 0.89 9.0 5.9 1.4 8.4 0.4 2.1 2 0 0 2 2 2 0 GrpE Spc24 PF08286.6 KII65347.1 - 0.97 9.1 7.4 5.5 6.7 3.0 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Sec2p PF06428.6 KII65347.1 - 1 9.2 6.0 0.55 10.1 0.7 2.4 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p THOC7 PF05615.8 KII65347.1 - 2.1 8.6 6.8 7.2 6.8 4.7 1.9 1 1 0 1 1 1 0 Tho complex subunit 7 YxiJ PF14176.1 KII65347.1 - 4 7.5 8.4 1 9.5 1.8 2.0 2 0 0 2 2 2 0 YxiJ-like protein RVP PF00077.15 KII65350.1 - 6.3e-08 32.4 0.6 2.3e-07 30.6 0.1 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Retrotrans_gag PF03732.12 KII65350.1 - 5e-05 23.2 0.1 0.00012 22.0 0.1 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.18 KII65350.1 - 7.8e-05 22.4 2.7 0.00013 21.6 1.9 1.4 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII65350.1 - 0.00017 21.9 0.1 0.00042 20.7 0.0 1.7 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII65350.1 - 0.00021 21.0 0.0 0.00046 19.9 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII65350.1 - 0.00073 19.0 0.2 0.002 17.6 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2E PF12382.3 KII65350.1 - 0.0016 18.2 0.0 0.0029 17.3 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon peptidase zf-CCHC_4 PF14392.1 KII65350.1 - 0.04 13.5 0.2 0.083 12.5 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle HR1 PF02185.11 KII65350.1 - 0.048 13.4 0.8 0.048 13.4 0.6 2.2 2 0 0 2 2 2 0 Hr1 repeat zf-CCHC_2 PF13696.1 KII65350.1 - 0.073 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Zinc knuckle DUF1759 PF03564.10 KII65350.1 - 0.12 12.1 1.0 0.35 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) SlyX PF04102.7 KII65350.1 - 0.19 12.1 0.3 0.19 12.1 0.2 2.3 2 0 0 2 2 2 0 SlyX zf-CCHC_5 PF14787.1 KII65350.1 - 0.26 10.8 2.2 0.47 9.9 1.5 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger TMF_DNA_bd PF12329.3 KII65350.1 - 5.5 6.8 8.3 0.43 10.4 1.4 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding EGF_2 PF07974.8 KII65352.1 - 0.034 14.3 6.5 0.064 13.4 4.5 1.5 1 0 0 1 1 1 0 EGF-like domain SNAP PF14938.1 KII65355.1 - 3.7e-08 32.8 8.4 8.1e-08 31.7 5.8 1.6 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.4 KII65355.1 - 0.00024 20.5 1.2 0.00083 18.7 0.6 1.9 1 1 1 2 2 2 1 26S proteasome subunit RPN7 TPR_12 PF13424.1 KII65355.1 - 0.0011 18.8 4.0 0.026 14.4 0.3 4.2 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII65355.1 - 0.0057 16.4 6.3 2.1 8.4 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 KII65355.1 - 0.0075 16.8 0.2 0.25 12.0 0.1 3.0 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 KII65355.1 - 0.028 14.8 3.1 26 5.5 0.0 4.5 5 2 0 5 5 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 KII65355.1 - 0.029 14.6 0.4 1.1 9.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Foie-gras_1 PF11817.3 KII65355.1 - 0.11 11.9 2.7 0.93 8.9 1.9 2.2 1 1 0 1 1 1 0 Foie gras liver health family 1 TPR_8 PF13181.1 KII65355.1 - 0.15 11.8 0.3 0.15 11.8 0.2 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 KII65355.1 - 0.22 12.2 2.5 20 5.9 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII65355.1 - 0.26 10.9 9.4 4.3 7.1 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.7 KII65355.1 - 0.27 11.0 11.2 12 5.8 0.2 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII65355.1 - 0.31 10.7 10.6 5.2 6.7 0.1 3.7 3 1 0 4 4 4 0 TPR repeat Clathrin PF00637.15 KII65355.1 - 0.8 9.3 8.4 0.29 10.7 0.9 2.5 2 1 1 3 3 3 0 Region in Clathrin and VPS TPR_7 PF13176.1 KII65355.1 - 0.88 9.5 6.6 7.9 6.5 0.1 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 KII65355.1 - 1.6 8.8 7.2 4.1 7.4 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.15 KII65355.1 - 8 7.5 18.0 1.3 9.8 1.7 4.8 5 0 0 5 5 4 0 Aromatic-di-Alanine (AdAR) repeat PBP PF01161.15 KII65357.1 - 0.00093 19.0 0.0 0.00099 18.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein cEGF PF12662.2 KII65358.1 - 0.2 11.3 1.5 0.42 10.2 1.0 1.5 1 0 0 1 1 1 0 Complement Clr-like EGF-like DUF2173 PF09941.4 KII65360.1 - 7.2e-06 25.8 0.0 29 4.6 0.0 5.2 5 1 0 5 5 5 0 Uncharacterized conserved protein (DUF2173) Ail_Lom PF06316.6 KII65360.1 - 0.00025 20.5 8.4 4.9 6.6 0.0 4.2 3 1 0 4 4 4 3 Enterobacterial Ail/Lom protein Fork_head PF00250.13 KII65360.1 - 0.0019 18.2 11.8 3.1 7.8 0.1 4.5 4 0 0 4 4 4 1 Fork head domain Methyltransf_30 PF05430.6 KII65360.1 - 0.018 14.6 0.9 61 3.2 0.0 3.9 4 0 0 4 4 4 0 S-adenosyl-L-methionine-dependent methyltransferase CAF1C_H4-bd PF12265.3 KII65360.1 - 0.064 13.1 0.7 70 3.4 0.0 3.6 1 1 3 4 4 4 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex Wyosine_form PF08608.7 KII65360.1 - 0.5 10.5 11.2 73 3.5 0.1 4.9 4 0 0 4 4 4 0 Wyosine base formation ADIP PF11559.3 KII65360.1 - 1.6 8.6 6.9 53 3.6 0.1 3.4 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Ima1_N PF09779.4 KII65360.1 - 5 7.6 18.5 5.7 7.4 0.3 6.3 5 2 3 8 8 8 0 Ima1 N-terminal domain SNAP PF14938.1 KII65362.1 - 2.1e-07 30.4 0.7 2.1e-07 30.4 0.5 1.4 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP DUF1091 PF06477.8 KII65362.1 - 0.013 15.9 5.7 0.55 10.6 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1091) DUF3067 PF11267.3 KII65363.1 - 0.071 13.2 0.0 0.089 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3067) DDE_Tnp_IS1595 PF12762.2 KII65364.1 - 4.2e-09 36.4 0.2 6.7e-08 32.4 0.1 2.4 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF3884 PF13024.1 KII65364.1 - 0.00041 19.7 0.0 0.00094 18.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3884) ATP-synt_B PF00430.13 KII65365.1 - 0.00033 20.4 0.1 0.0005 19.8 0.1 1.3 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) DUF2897 PF11446.3 KII65370.1 - 0.12 12.2 0.9 0.31 10.8 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) Poxvirus PF06227.7 KII65370.1 - 0.15 11.5 1.9 0.16 11.4 0.9 1.4 1 1 0 1 1 1 0 dsDNA Poxvirus LSM PF01423.17 KII65372.1 - 4e-12 45.5 0.1 5.4e-12 45.0 0.1 1.2 1 0 0 1 1 1 1 LSM domain ADH_N PF08240.7 KII65372.1 - 0.031 14.0 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain MEF2_binding PF09047.5 KII65372.1 - 0.15 11.7 0.3 0.32 10.6 0.2 1.5 1 0 0 1 1 1 0 MEF2 binding zf-Sec23_Sec24 PF04810.10 KII65373.1 - 0.01 15.3 0.4 0.019 14.4 0.3 1.5 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger zf-A20 PF01754.11 KII65373.1 - 0.081 12.5 0.2 0.18 11.4 0.2 1.6 1 0 0 1 1 1 0 A20-like zinc finger Iso_dh PF00180.15 KII65374.1 - 8.5e-40 136.7 0.0 1e-39 136.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUSP PF06337.7 KII65375.1 - 0.038 14.3 0.1 5.1 7.5 0.0 2.4 2 0 0 2 2 2 0 DUSP domain CDK5_activator PF03261.10 KII65375.1 - 0.073 12.4 1.4 0.11 11.7 1.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein CNTF PF01110.12 KII65376.1 - 0.034 13.4 0.0 0.044 13.0 0.0 1.1 1 0 0 1 1 1 0 Ciliary neurotrophic factor HTH_29 PF13551.1 KII65377.1 - 6.5e-07 29.4 0.0 9.2e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII65377.1 - 5.4e-05 23.0 0.1 0.0041 17.1 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.13 KII65377.1 - 0.0011 18.7 0.1 0.0019 17.9 0.0 1.4 2 0 0 2 2 2 1 'Paired box' domain HTH_23 PF13384.1 KII65377.1 - 0.0039 16.7 0.9 0.048 13.3 0.0 2.7 2 1 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.1 KII65377.1 - 0.0069 15.9 0.1 0.013 15.0 0.1 1.6 1 1 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII65377.1 - 0.016 15.9 0.0 0.042 14.6 0.0 1.7 1 1 1 2 2 2 0 Homeodomain-like domain DUF1323 PF07037.6 KII65377.1 - 0.031 14.4 0.0 0.046 13.8 0.0 1.3 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) Sua5_yciO_yrdC PF01300.13 KII65378.1 - 3e-32 111.3 0.0 3.3e-32 111.1 0.0 1.0 1 0 0 1 1 1 1 Telomere recombination S10_plectin PF03501.10 KII65379.1 - 2.7e-33 113.6 0.0 3.2e-33 113.4 0.0 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF1985 PF09331.6 KII65379.1 - 0.044 13.5 0.0 0.1 12.3 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1985) FLYWCH PF04500.11 KII65380.1 - 9.6e-11 41.4 2.5 9.6e-11 41.4 1.7 1.7 2 0 0 2 2 2 1 FLYWCH zinc finger domain PTEN_C2 PF10409.4 KII65381.1 - 7.6e-09 35.4 0.4 1.3e-08 34.6 0.3 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.15 KII65381.1 - 1.3e-05 24.8 0.4 7.6e-05 22.2 0.0 2.4 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KII65381.1 - 9.7e-05 21.8 0.0 0.0002 20.8 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KII65381.1 - 0.00077 19.5 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.7 KII65381.1 - 0.0022 17.4 0.1 0.0042 16.5 0.0 1.5 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.1 KII65381.1 - 0.0022 18.2 0.0 0.0058 16.8 0.0 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family Ldl_recept_a PF00057.13 KII65382.1 - 7.5e-42 140.9 110.1 4.7e-10 39.1 2.0 8.0 7 0 0 7 7 7 7 Low-density lipoprotein receptor domain class A DUF778 PF05608.7 KII65382.1 - 0.00022 21.1 2.0 0.0062 16.4 0.1 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF778) BNR PF02012.15 KII65382.1 - 0.013 15.1 11.0 5.3 7.3 0.1 5.9 6 0 0 6 6 6 0 BNR/Asp-box repeat Brix PF04427.13 KII65383.1 - 6.2e-17 61.8 0.2 9.6e-17 61.2 0.1 1.3 1 0 0 1 1 1 1 Brix domain RNB PF00773.14 KII65384.1 - 4.4e-36 124.8 0.0 6.1e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 RNB domain AdoHcyase PF05221.12 KII65386.1 - 9.8e-44 149.2 0.0 1.2e-43 149.0 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase DWNN PF08783.6 KII65388.1 - 0.16 11.9 3.3 0.67 9.9 0.1 2.8 2 0 0 2 2 2 0 DWNN domain HTH_29 PF13551.1 KII65390.1 - 1.7e-07 31.3 0.3 8.5e-07 29.1 0.0 1.9 1 1 1 2 2 2 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII65390.1 - 9.4e-06 25.6 1.1 0.00028 20.8 0.0 3.2 2 1 1 3 3 3 1 Transposase HTH_32 PF13565.1 KII65390.1 - 3.3e-05 24.5 0.2 0.0005 20.8 0.0 2.2 1 1 1 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII65390.1 - 6.7e-05 22.7 0.1 0.00025 20.9 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 KII65390.1 - 0.00015 21.2 0.5 0.00036 20.0 0.1 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII65390.1 - 0.0009 18.9 0.6 0.0016 18.0 0.2 1.6 1 1 0 1 1 1 1 Transposase HTH_24 PF13412.1 KII65390.1 - 0.0059 15.9 0.1 0.13 11.7 0.0 2.6 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding RPA_C PF08784.6 KII65390.1 - 0.0088 16.4 2.9 0.015 15.7 2.0 1.3 1 0 0 1 1 1 1 Replication protein A C terminal Phage_RpbA PF10789.4 KII65390.1 - 0.011 15.5 0.3 0.02 14.6 0.2 1.5 1 0 0 1 1 1 0 Phage RNA polymerase binding, RpbA Rrf2 PF02082.15 KII65390.1 - 0.019 15.0 1.3 0.055 13.5 0.0 2.5 2 1 1 3 3 3 0 Transcriptional regulator NUMOD1 PF07453.8 KII65390.1 - 0.034 13.9 1.3 0.25 11.2 0.0 2.8 3 0 0 3 3 3 0 NUMOD1 domain Peptidase_C11 PF03415.9 KII65390.1 - 0.036 13.0 0.3 0.038 12.9 0.2 1.1 1 0 0 1 1 1 0 Clostripain family HTH_Tnp_1 PF01527.15 KII65390.1 - 0.091 12.7 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Transposase Vma12 PF11712.3 KII65390.1 - 0.28 10.8 2.9 0.52 10.0 2.0 1.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase HHH_4 PF14490.1 KII65390.1 - 0.49 10.1 5.4 20 5.0 0.0 3.2 2 2 1 3 3 3 0 Helix-hairpin-helix containing domain DUF3106 PF11304.3 KII65390.1 - 0.84 10.0 6.3 2.7 8.4 4.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) DDE_3 PF13358.1 KII65391.1 - 2.4e-17 63.0 0.0 3.6e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII65391.1 - 0.038 14.0 0.0 0.06 13.4 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain SNAP PF14938.1 KII65392.1 - 3.3e-06 26.4 0.2 5.4e-06 25.7 0.1 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII65392.1 - 0.42 10.6 2.0 23 5.2 0.1 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII65392.1 - 2.4 8.1 4.9 6 6.9 0.1 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat DDE_3 PF13358.1 KII65393.1 - 0.00016 21.4 0.3 0.0071 16.1 0.2 2.5 1 1 0 1 1 1 1 DDE superfamily endonuclease Retrotrans_gag PF03732.12 KII65393.1 - 0.036 14.1 1.3 0.064 13.3 0.1 2.0 2 0 0 2 2 2 0 Retrotransposon gag protein NGF PF00243.13 KII65395.1 - 0.072 12.8 0.8 0.84 9.3 0.2 2.1 1 1 1 2 2 2 0 Nerve growth factor family Atracotoxin PF05353.6 KII65400.1 - 0.077 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Delta Atracotoxin Epimerase PF01370.16 KII65401.1 - 2.5e-16 59.8 0.0 3.4e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 KII65401.1 - 0.0065 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit Epimerase PF01370.16 KII65402.1 - 1.1e-08 34.8 0.0 1.2e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF4451 PF14616.1 KII65402.1 - 0.15 11.8 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) HTH_29 PF13551.1 KII65403.1 - 3e-07 30.5 0.0 4.7e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII65403.1 - 4.6e-06 26.1 0.0 1e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.1 KII65403.1 - 7.1e-06 25.4 0.0 0.00039 19.9 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.1 KII65403.1 - 1.7e-05 24.7 0.1 3.1e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.13 KII65403.1 - 0.00025 20.7 0.1 0.00051 19.7 0.0 1.5 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.1 KII65403.1 - 0.0076 16.0 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII65403.1 - 0.0078 15.8 0.1 0.015 14.9 0.1 1.4 1 0 0 1 1 1 1 Transposase HTH_11 PF08279.7 KII65403.1 - 0.027 14.0 0.2 0.068 12.8 0.1 1.7 1 0 0 1 1 1 0 HTH domain HTH_40 PF14493.1 KII65403.1 - 0.046 13.9 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.15 KII65403.1 - 0.066 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Transposase CENP-B_N PF04218.8 KII65404.1 - 4.6e-05 22.7 0.2 0.00017 20.9 0.1 1.9 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_IclR PF09339.5 KII65404.1 - 0.00083 18.8 0.0 0.029 13.9 0.0 2.2 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_10 PF04967.7 KII65404.1 - 0.001 18.6 0.0 0.18 11.4 0.0 2.3 2 0 0 2 2 2 1 HTH DNA binding domain HTH_3 PF01381.17 KII65404.1 - 0.0039 16.9 2.6 0.087 12.6 0.0 2.7 3 0 0 3 3 3 1 Helix-turn-helix HTH_24 PF13412.1 KII65404.1 - 0.0089 15.3 0.6 0.069 12.5 0.1 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.1 KII65404.1 - 0.012 15.2 0.1 0.038 13.6 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_Tc5 PF03221.11 KII65404.1 - 0.015 15.0 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain HTH_38 PF13936.1 KII65404.1 - 0.019 14.5 0.2 0.052 13.1 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_psq PF05225.11 KII65404.1 - 0.021 14.3 0.0 0.049 13.2 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_AsnC-type PF13404.1 KII65404.1 - 0.028 13.9 0.1 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain RHH_1 PF01402.16 KII65404.1 - 0.031 14.1 2.1 2.1 8.3 0.4 2.8 3 0 0 3 3 3 0 Ribbon-helix-helix protein, copG family HTH_28 PF13518.1 KII65404.1 - 0.051 13.6 0.0 0.22 11.5 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain LacI PF00356.16 KII65404.1 - 0.065 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family RHH_3 PF12651.2 KII65404.1 - 0.17 11.6 1.3 2.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Ribbon-helix-helix domain MFS_1 PF07690.11 KII65405.1 - 1.5e-33 116.0 28.7 4.6e-32 111.0 17.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4371 PF14291.1 KII65406.1 - 9.9e-12 44.9 2.1 1.3e-11 44.5 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.9 KII65406.1 - 3.6e-06 26.5 0.1 9.2e-06 25.2 0.1 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Med9 PF07544.8 KII65406.1 - 0.82 9.4 4.2 1.3 8.7 0.0 3.0 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 GvpG PF05120.7 KII65409.1 - 0.041 13.6 0.8 0.071 12.9 0.6 1.3 1 0 0 1 1 1 0 Gas vesicle protein G MAP7 PF05672.6 KII65409.1 - 0.35 10.2 12.1 0.41 9.9 8.4 1.3 1 1 0 1 1 1 0 MAP7 (E-MAP-115) family U79_P34 PF03064.11 KII65409.1 - 1.5 8.2 9.1 1.9 7.9 6.3 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 V_ATPase_I PF01496.14 KII65409.1 - 2 6.1 5.5 2.4 5.8 3.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nop52 PF05997.7 KII65410.1 - 0.02 14.3 0.2 0.056 12.8 0.1 1.6 1 1 1 2 2 2 0 Nucleolar protein,Nop52 Rifin_STEVOR PF02009.11 KII65411.1 - 0.062 12.9 1.8 0.094 12.3 1.2 1.3 1 1 0 1 1 1 0 Rifin/stevor family COX2_TM PF02790.10 KII65413.1 - 0.18 11.7 5.5 0.08 12.9 1.6 2.0 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain Cypo_polyhedrin PF05865.6 KII65414.1 - 0.043 13.0 0.3 0.05 12.8 0.2 1.1 1 0 0 1 1 1 0 Cypovirus polyhedrin protein Pkinase PF00069.20 KII65416.1 - 2.5e-70 236.5 0.2 7.4e-70 235.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII65416.1 - 3.8e-38 131.0 0.0 1.2e-37 129.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase POLO_box PF00659.13 KII65416.1 - 1.3e-33 114.7 0.7 2.4e-19 69.0 0.0 2.5 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.1 KII65416.1 - 3.3e-09 36.1 0.0 3e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like GRAM PF02893.15 KII65417.1 - 0.012 15.0 0.1 0.027 13.9 0.1 1.6 1 0 0 1 1 1 0 GRAM domain Hus1 PF04005.7 KII65419.1 - 0.032 13.1 0.1 0.044 12.7 0.1 1.3 1 0 0 1 1 1 0 Hus1-like protein EMP24_GP25L PF01105.19 KII65422.1 - 6e-23 81.4 2.0 6.6e-23 81.3 1.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Kelch_6 PF13964.1 KII65424.1 - 2.9e-24 84.1 25.3 1.8e-06 27.8 0.6 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII65424.1 - 6.3e-21 73.6 24.1 3.4e-05 23.3 0.3 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII65424.1 - 2.8e-14 52.6 21.6 0.0018 18.0 0.0 5.7 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII65424.1 - 5.7e-13 48.5 12.3 0.027 14.4 0.0 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 KII65424.1 - 9.8e-11 41.5 17.6 0.00036 20.6 0.0 6.8 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII65424.1 - 1.2e-10 40.7 14.5 0.017 14.8 0.0 5.5 5 0 0 5 5 5 5 Kelch motif SEO_C PF14577.1 KII65424.1 - 0.042 13.2 0.5 0.16 11.3 0.3 1.9 1 1 1 2 2 2 0 Sieve element occlusion C-terminus Integrin_beta PF00362.13 KII65425.1 - 1.6e-07 30.5 0.1 2e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Integrin, beta chain PSI PF01437.20 KII65425.1 - 0.032 14.3 3.1 0.052 13.6 2.2 1.4 1 1 0 1 1 1 0 Plexin repeat CompInhib_SCIN PF11546.3 KII65426.1 - 0.093 12.5 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Staphylococcal complement inhibitor SCIN RVT_1 PF00078.22 KII65428.1 - 0.017 14.4 0.1 0.029 13.7 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) M11L PF11099.3 KII65428.1 - 0.025 14.3 0.3 2.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Apoptosis regulator M11L like Herpes_pp85 PF04637.7 KII65428.1 - 0.037 12.3 0.0 1.9 6.7 0.0 2.0 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Ldl_recept_a PF00057.13 KII65430.1 - 1.1e-10 41.1 26.1 2.3e-06 27.3 5.8 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A HTH_23 PF13384.1 KII65433.1 - 0.0023 17.5 0.1 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.1 KII65433.1 - 0.0099 15.4 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Helicase_C PF00271.26 KII65433.1 - 0.06 13.2 0.2 0.1 12.5 0.1 1.4 1 1 0 1 1 1 0 Helicase conserved C-terminal domain HTH_28 PF13518.1 KII65433.1 - 0.071 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain UPF0193 PF05250.6 KII65433.1 - 0.076 12.5 0.1 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0193) Glycos_transf_2 PF00535.21 KII65434.1 - 1.3e-26 93.2 0.1 1.9e-26 92.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII65434.1 - 8.7e-06 25.6 0.0 1.3e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KII65434.1 - 3.6e-05 22.9 0.1 5.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Arabinose_trans PF04602.7 KII65434.1 - 0.019 13.1 0.5 0.026 12.7 0.4 1.1 1 0 0 1 1 1 0 Mycobacterial cell wall arabinan synthesis protein Glucos_trans_II PF14264.1 KII65435.1 - 2e-08 33.6 33.6 2e-08 33.6 23.3 2.7 1 1 2 3 3 3 1 Glucosyl transferase GtrII DUF3814 PF12769.2 KII65435.1 - 0.0047 17.0 0.7 0.019 15.0 0.4 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3814) Integrase_1 PF12835.2 KII65436.1 - 2.2e-26 92.7 0.6 4.2e-26 91.8 0.4 1.5 1 0 0 1 1 1 1 Integrase TPR_11 PF13414.1 KII65436.1 - 3.5e-18 65.0 9.4 1.6e-14 53.2 1.8 4.4 4 0 0 4 4 4 1 TPR repeat DUF4365 PF14280.1 KII65436.1 - 1.4e-16 60.4 0.3 2.4e-16 59.7 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4365) TPR_2 PF07719.12 KII65436.1 - 2e-13 49.1 8.9 1.1e-05 25.0 0.5 4.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 KII65436.1 - 8e-13 48.5 2.0 3.1e-07 30.6 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KII65436.1 - 2e-11 44.2 0.9 5.6e-06 26.8 0.0 4.3 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 KII65436.1 - 3.5e-09 36.4 2.6 3.9e-06 27.0 0.0 4.2 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII65436.1 - 4.1e-09 36.2 8.6 7.5e-09 35.4 0.3 4.0 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII65436.1 - 8.8e-09 34.6 16.1 2.3e-06 26.9 0.1 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat Apc3 PF12895.2 KII65436.1 - 1.5e-06 28.2 9.0 0.00091 19.3 0.3 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 KII65436.1 - 0.00011 22.1 0.5 0.00011 22.1 0.4 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat ChAPs PF09295.5 KII65436.1 - 0.0002 20.2 2.2 0.061 12.0 0.1 2.6 3 0 0 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.3 KII65436.1 - 0.00035 19.4 1.8 0.0013 17.6 0.1 2.5 3 0 0 3 3 3 1 NMDA receptor-regulated protein 1 TPR_7 PF13176.1 KII65436.1 - 0.00046 19.7 0.1 1.5 8.7 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.1 KII65436.1 - 0.00049 20.1 0.5 0.26 11.4 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 KII65436.1 - 0.0015 18.3 0.9 0.24 11.2 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KII65436.1 - 0.0019 17.8 9.1 0.032 14.0 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 KII65436.1 - 0.0092 16.3 3.4 5.4 7.6 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 KII65436.1 - 0.018 14.1 0.0 0.19 10.7 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.12 KII65436.1 - 0.069 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial transcriptional activator domain DUF4326 PF14216.1 KII65437.1 - 8.3e-25 87.1 0.0 1.3e-24 86.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4326) DUF488 PF04343.8 KII65438.1 - 2.3e-25 89.3 0.1 2.6e-25 89.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF488 Rep_1 PF01446.12 KII65439.1 - 3.8e-15 55.8 2.6 1.6e-14 53.8 0.3 2.0 2 0 0 2 2 2 2 Replication protein Arylesterase PF01731.15 KII65443.1 - 0.057 13.4 0.5 0.057 13.4 0.4 1.6 2 0 0 2 2 2 0 Arylesterase DUF1132 PF06575.7 KII65443.1 - 0.07 13.4 3.1 0.086 13.1 1.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1132) Tafi-CsgC PF10610.4 KII65445.1 - 0.067 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Thin aggregative fimbriae synthesis protein FAM60A PF15396.1 KII65446.1 - 2e-07 30.9 5.2 8.3e-07 28.9 0.0 2.1 1 1 1 2 2 2 1 Protein Family FAM60A FAM60A PF15396.1 KII65447.1 - 2.2e-05 24.3 0.1 3.9e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Protein Family FAM60A Cmyb_C PF09316.5 KII65447.1 - 0.066 12.8 0.4 9 5.9 0.0 2.1 2 0 0 2 2 2 0 C-myb, C-terminal DUF2427 PF10348.4 KII65450.1 - 0.069 12.7 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) FAM60A PF15396.1 KII65451.1 - 1.3e-05 25.1 0.1 1.3e-05 25.1 0.0 2.0 1 1 1 2 2 2 1 Protein Family FAM60A DDE_3 PF13358.1 KII65454.1 - 1.7e-06 27.8 0.0 3e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease NYD-SP28 PF14772.1 KII65454.1 - 0.12 12.4 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 Sperm tail Pox_F15 PF04596.7 KII65455.1 - 0.0073 15.8 0.1 0.014 14.9 0.1 1.4 1 1 0 1 1 1 1 Poxvirus protein F15 Peptidase_C1 PF00112.18 KII65456.1 - 1.1e-46 159.4 0.0 1.8e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII65456.1 - 7.3e-07 29.3 3.0 1.8e-06 28.0 2.1 1.7 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) WD40 PF00400.27 KII65459.1 - 4.2e-36 121.5 19.6 4.4e-10 39.0 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 KII65459.1 - 8e-10 38.7 1.5 0.00037 20.2 0.1 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A DPPIV_N PF00930.16 KII65459.1 - 0.0011 17.6 0.4 0.48 8.9 0.1 3.0 2 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region MMS1_N PF10433.4 KII65459.1 - 0.0053 14.9 0.0 0.042 11.9 0.0 2.2 3 0 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Cyt-b5 PF00173.23 KII65459.1 - 0.0075 16.0 0.0 0.17 11.7 0.0 2.3 1 1 1 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Coatomer_WDAD PF04053.9 KII65459.1 - 0.0081 15.0 3.3 0.4 9.4 0.2 3.1 2 1 1 3 3 3 1 Coatomer WD associated region DUF3312 PF11768.3 KII65459.1 - 0.017 13.3 0.0 0.025 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) Arylsulfotran_2 PF14269.1 KII65459.1 - 0.026 13.6 0.2 0.05 12.7 0.1 1.5 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) Gmad1 PF10647.4 KII65459.1 - 0.084 12.2 0.0 1.8 7.8 0.0 2.8 3 1 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain Cytochrom_D1 PF02239.11 KII65459.1 - 0.09 11.0 0.1 19 3.4 0.0 2.9 2 1 0 3 3 3 0 Cytochrome D1 heme domain rve PF00665.21 KII65460.1 - 1.5e-24 86.4 0.0 4e-24 85.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII65460.1 - 2.6e-20 72.7 0.1 6.8e-20 71.3 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII65460.1 - 4.9e-05 23.1 0.1 0.00017 21.4 0.0 2.0 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII65460.1 - 7.6e-05 22.4 0.0 0.00016 21.4 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII65460.1 - 0.001 19.4 0.0 0.0027 18.1 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease rve_3 PF13683.1 KII65460.1 - 0.017 14.6 0.1 0.055 12.9 0.1 1.9 1 0 0 1 1 1 0 Integrase core domain zf-CCHC PF00098.18 KII65460.1 - 5.6 7.0 8.2 1.9 8.5 1.1 2.7 2 0 0 2 2 2 0 Zinc knuckle Pkinase PF00069.20 KII65461.1 - 1.1e-55 188.6 3.4 3.5e-55 186.9 2.3 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII65461.1 - 6.1e-36 123.8 1.0 7.8e-36 123.4 0.7 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KII65461.1 - 0.0067 15.5 0.3 0.011 14.7 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 KII65461.1 - 0.046 13.2 1.3 0.066 12.7 0.3 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase SAB PF04382.8 KII65462.1 - 0.056 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 SAB domain rve PF00665.21 KII65463.1 - 3.7e-11 43.1 0.0 4.4e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65463.1 - 0.0058 16.1 0.0 0.0074 15.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Retrotrans_gag PF03732.12 KII65465.1 - 0.013 15.6 0.0 0.022 14.7 0.0 1.6 1 1 0 1 1 1 0 Retrotransposon gag protein UBN2 PF14223.1 KII65465.1 - 0.14 11.9 0.1 1.8 8.3 0.0 2.0 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type rve PF00665.21 KII65466.1 - 1.1e-08 35.2 0.0 2.4e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII65466.1 - 0.043 13.7 0.0 0.73 9.7 0.0 2.4 2 0 0 2 2 2 0 Retroviral aspartyl protease RVT_1 PF00078.22 KII65467.1 - 1.4e-10 40.8 0.1 2.2e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.1 KII65467.1 - 0.00012 21.7 0.0 0.00027 20.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII65467.1 - 0.00075 19.3 0.0 0.027 14.3 0.0 2.6 1 1 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.6 KII65467.1 - 0.01 15.7 0.1 4.3 7.2 0.0 3.1 2 1 1 3 3 3 0 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII65467.1 - 0.04 14.4 0.0 0.22 12.0 0.0 2.2 1 1 1 2 2 2 0 Aspartyl protease rve PF00665.21 KII65469.1 - 2.1e-20 73.0 0.1 9.7e-12 45.0 0.0 3.4 2 1 0 2 2 2 2 Integrase core domain rve PF00665.21 KII65470.1 - 0.0091 16.0 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Hema_esterase PF03996.10 KII65470.1 - 0.086 12.0 0.0 0.086 12.0 0.0 1.1 1 0 0 1 1 1 0 Hemagglutinin esterase Kelch_6 PF13964.1 KII65471.1 - 4.1e-16 58.3 18.2 0.001 19.1 0.2 6.4 4 1 2 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KII65471.1 - 2.3e-11 43.0 14.1 0.00036 20.0 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 KII65471.1 - 5.2e-10 39.0 3.4 0.00027 20.7 0.1 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.1 KII65471.1 - 5.7e-10 39.0 6.1 0.015 15.4 0.1 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII65471.1 - 2.3e-08 33.6 22.6 0.0014 18.3 0.3 6.5 4 2 1 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KII65471.1 - 1.1 9.1 7.7 4.3 7.2 0.0 4.6 6 0 0 6 6 6 0 Kelch motif Kelch_6 PF13964.1 KII65473.1 - 1.8e-14 53.2 8.2 0.00032 20.7 0.1 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 KII65473.1 - 4.3e-10 39.4 4.2 0.0014 18.7 0.0 4.4 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII65473.1 - 4.2e-09 36.0 11.5 9.4e-05 22.1 0.0 5.4 3 2 2 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII65473.1 - 9.1e-09 34.7 9.3 0.0014 18.1 0.1 4.2 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 KII65473.1 - 0.00075 19.1 3.1 1.4 8.8 0.0 3.7 4 0 0 4 4 4 2 Kelch motif FBA_1 PF07734.8 KII65473.1 - 0.036 13.7 0.5 0.075 12.7 0.4 1.5 1 0 0 1 1 1 0 F-box associated Kelch_5 PF13854.1 KII65473.1 - 0.1 12.5 0.5 0.58 10.1 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.1 KII65474.1 - 6.8e-16 57.9 2.6 0.0041 17.2 0.0 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.1 KII65474.1 - 4.6e-15 55.0 18.8 1.9e-05 24.6 0.2 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KII65474.1 - 1.9e-14 52.9 16.8 2.3e-06 27.0 0.2 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII65474.1 - 6.5e-11 41.8 23.7 0.00032 20.3 0.2 6.4 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KII65474.1 - 1.1e-06 28.1 12.3 0.0036 17.0 0.1 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.1 KII65474.1 - 0.2 11.6 16.7 0.32 11.0 0.2 5.3 5 1 0 5 5 5 0 Kelch motif Kelch_6 PF13964.1 KII65476.1 - 1.1e-19 69.7 14.9 4.3e-05 23.4 0.2 6.4 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII65476.1 - 3e-18 65.3 13.7 8e-05 22.3 0.0 6.2 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII65476.1 - 1.1e-16 60.0 11.9 4e-06 26.2 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 KII65476.1 - 6.4e-15 54.8 2.7 0.0068 16.5 0.0 6.0 5 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII65476.1 - 7e-07 28.7 12.4 0.032 14.0 0.1 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 KII65476.1 - 8.7e-07 28.7 10.7 0.1 12.5 0.0 6.2 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.1 KII65477.1 - 5.9e-19 67.3 20.0 2.5e-06 27.4 0.2 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KII65477.1 - 1.1e-18 66.5 17.9 2e-06 27.2 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII65477.1 - 1.6e-16 59.7 20.1 0.00013 21.6 0.0 6.7 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII65477.1 - 1.6e-12 47.1 13.1 0.0056 16.8 0.0 6.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII65477.1 - 1.9e-12 46.8 11.3 0.00017 21.4 0.1 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KII65477.1 - 3.5e-11 42.3 13.8 0.057 13.2 0.0 6.2 6 0 0 6 6 6 6 Kelch motif DDE_3 PF13358.1 KII65478.1 - 0.022 14.5 0.0 0.027 14.2 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Bcr-Abl_Oligo PF09036.5 KII65479.1 - 0.076 12.9 0.4 0.19 11.6 0.1 1.9 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Cbl_N2 PF02761.9 KII65481.1 - 0.035 14.1 0.4 0.14 12.2 0.2 1.8 1 1 1 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain RNase_T PF00929.19 KII65482.1 - 0.029 14.6 0.0 0.035 14.4 0.0 1.2 1 0 0 1 1 1 0 Exonuclease ADAM_CR PF08516.7 KII65483.1 - 0.0058 16.6 1.7 0.28 11.2 0.1 2.1 2 0 0 2 2 2 2 ADAM cysteine-rich Folate_rec PF03024.9 KII65484.1 - 0.063 12.8 0.5 0.15 11.7 0.1 1.7 1 1 0 1 1 1 0 Folate receptor family DUF4489 PF14879.1 KII65486.1 - 0.12 11.9 0.1 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4489) Vpu PF00558.14 KII65487.1 - 0.077 12.5 2.3 0.96 9.0 0.1 2.1 2 0 0 2 2 2 0 Vpu protein Gliadin PF13016.1 KII65491.1 - 0.035 14.2 2.3 0.095 12.9 1.0 2.0 2 0 0 2 2 2 0 Cys-rich Gliadin N-terminal ERAP1_C PF11838.3 KII65494.1 - 1.5e-14 54.0 0.0 2.7e-14 53.1 0.0 1.5 1 1 0 1 1 1 1 ERAP1-like C-terminal domain DUF1336 PF07059.7 KII65494.1 - 0.0023 17.4 0.1 0.0043 16.4 0.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1336) IstB_IS21_ATP PF08483.6 KII65494.1 - 0.0078 15.8 0.4 0.013 15.1 0.3 1.3 1 0 0 1 1 1 1 IstB-like ATP binding N-terminal PP2C PF00481.16 KII65501.1 - 4.8e-67 226.0 0.0 7.1e-67 225.4 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.8 KII65501.1 - 3e-07 30.4 0.1 6.7e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.1 KII65501.1 - 8.9e-07 28.5 0.0 2.2e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SelP_N PF04592.9 KII65502.1 - 0.068 12.5 0.0 0.087 12.1 0.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MFS_1 PF07690.11 KII65505.1 - 2.8e-05 22.9 0.5 3.3e-05 22.7 0.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4040 PF13244.1 KII65505.1 - 0.034 14.1 0.5 0.074 13.0 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) DUF1469 PF07332.6 KII65505.1 - 0.052 13.2 0.1 0.082 12.6 0.0 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1469) BPD_transp_2 PF02653.11 KII65505.1 - 0.054 12.4 1.9 0.05 12.5 0.9 1.2 1 1 0 1 1 1 0 Branched-chain amino acid transport system / permease component ATG22 PF11700.3 KII65505.1 - 0.17 10.3 3.3 0.19 10.1 2.3 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like KLRAQ PF10205.4 KII65506.1 - 0.0053 16.7 3.2 0.0095 15.9 2.2 1.3 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein Spt5_N PF11942.3 KII65506.1 - 0.25 11.9 2.2 0.41 11.2 1.5 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DDE_3 PF13358.1 KII65507.1 - 1.6e-07 31.2 0.0 1.7e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_hydr_30_2 PF14587.1 KII65507.1 - 0.05 12.5 0.0 0.087 11.7 0.0 1.3 2 0 0 2 2 2 0 O-Glycosyl hydrolase family 30 rve PF00665.21 KII65508.1 - 2.4e-23 82.5 0.0 1.2e-22 80.2 0.0 2.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII65508.1 - 2.2e-15 56.5 0.0 1.2e-14 54.2 0.0 2.2 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII65508.1 - 0.0026 17.2 0.0 0.0067 15.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII65510.1 - 2.5e-05 23.7 0.0 0.014 14.8 0.0 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Metallophos PF00149.23 KII65511.1 - 8.7e-06 25.2 0.2 1.1e-05 24.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KII65511.1 - 0.038 13.8 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain DASH_Dad4 PF08650.5 KII65511.1 - 0.082 12.8 1.7 0.12 12.3 0.5 1.8 1 1 1 2 2 2 0 DASH complex subunit Dad4 RVT_1 PF00078.22 KII65512.1 - 1.2e-27 96.7 0.2 3.4e-27 95.2 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII65512.1 - 5.1e-25 87.8 0.0 1.5e-24 86.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65512.1 - 0.00065 19.1 2.4 0.00078 18.9 0.0 2.5 3 0 0 3 3 3 1 Integrase core domain Spuma_A9PTase PF03539.9 KII65512.1 - 0.016 15.1 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-MIZ PF02891.15 KII65513.1 - 5.9e-18 64.1 3.0 1.1e-17 63.3 2.1 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 KII65513.1 - 7.4e-07 28.6 1.7 7.4e-07 28.6 1.2 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit PINIT PF14324.1 KII65513.1 - 6.7e-06 26.2 0.1 1.5e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 PINIT domain zf-C3HC4_4 PF15227.1 KII65513.1 - 0.33 10.8 7.9 0.5 10.2 3.7 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 KII65513.1 - 0.34 10.7 3.3 0.77 9.6 2.3 1.7 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 KII65513.1 - 1.9 8.5 6.7 1.2 9.2 2.5 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII65513.1 - 3.2 7.5 6.0 1 9.0 1.9 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF2877 PF11392.3 KII65519.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2877) DUF2009 PF09418.5 KII65521.1 - 0.052 12.3 0.1 0.052 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) EMP24_GP25L PF01105.19 KII65522.1 - 1.4e-21 77.0 4.3 1.6e-21 76.8 3.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD NTF2 PF02136.15 KII65522.1 - 0.039 14.3 0.1 0.072 13.4 0.0 1.4 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain Acetyltransf_11 PF13720.1 KII65522.1 - 0.1 12.8 0.4 9.3 6.5 0.0 2.3 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 SARS_3b PF12383.3 KII65523.1 - 0.019 14.9 0.1 0.021 14.7 0.1 1.2 1 0 0 1 1 1 0 Severe acute respiratory syndrome coronavirus 3b protein YARHG PF13308.1 KII65525.1 - 0.032 13.7 0.2 0.083 12.4 0.2 1.9 1 1 0 1 1 1 0 YARHG domain DUF458 PF04308.7 KII65525.1 - 0.042 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF458) Pox_H7 PF04787.7 KII65525.1 - 0.11 12.3 4.2 2.6 7.8 0.4 2.3 1 1 1 2 2 2 0 Late protein H7 rve PF00665.21 KII65532.1 - 4.9e-13 49.2 0.0 7.8e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65532.1 - 5.5e-06 25.8 0.0 1.5e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII65533.1 - 3.4e-05 23.6 0.0 6.2e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.6 KII65533.1 - 0.00096 19.1 0.2 0.0014 18.5 0.2 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII65533.1 - 0.016 15.7 0.0 0.024 15.1 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease Toxin_55 PF15606.1 KII65535.1 - 0.048 13.6 0.3 0.73 9.8 0.0 2.1 2 0 0 2 2 2 0 Putative toxin 55 ASXH PF13919.1 KII65544.1 - 0.12 12.1 1.2 0.42 10.4 0.8 1.7 1 1 0 1 1 1 0 Asx homology domain DUF737 PF05300.6 KII65544.1 - 0.16 11.9 1.1 0.2 11.5 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF1637 PF07847.7 KII65546.1 - 8e-21 74.3 0.1 1.1e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1637) Telomere_Sde2_2 PF13297.1 KII65547.1 - 6.8e-10 38.0 0.1 1.9e-09 36.6 0.0 1.8 1 0 0 1 1 1 1 Telomere stability C-terminal SF3a60_bindingd PF12108.3 KII65547.1 - 1.7e-09 37.0 0.7 1.7e-09 37.0 0.5 2.8 3 0 0 3 3 3 1 Splicing factor SF3a60 binding domain VASP_tetra PF08776.6 KII65547.1 - 0.076 12.3 1.0 0.21 10.9 0.7 1.8 1 0 0 1 1 1 0 VASP tetramerisation domain RNase_PH PF01138.16 KII65548.1 - 1.1e-07 32.2 0.0 1.8e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 KII65548.1 - 0.03 14.2 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 SNAP PF14938.1 KII65549.1 - 6.1e-09 35.4 0.5 7.5e-09 35.1 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII65549.1 - 0.01 15.4 0.4 0.01 15.4 0.3 2.0 2 0 0 2 2 2 0 TPR repeat TPR_12 PF13424.1 KII65549.1 - 0.13 12.2 3.5 6.2 6.8 1.5 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.4 KII65549.1 - 0.39 10.0 3.0 5.3 6.3 0.0 2.9 2 1 1 3 3 3 0 26S proteasome subunit RPN7 NSF PF02071.15 KII65549.1 - 0.84 10.4 4.1 2.8 8.9 0.0 3.8 3 1 1 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.1 KII65549.1 - 1.4 8.9 5.0 1.2 9.1 0.4 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TACI-CRD2 PF09305.5 KII65550.1 - 0.32 10.8 1.8 15 5.5 0.1 2.8 3 0 0 3 3 3 0 TACI, cysteine-rich domain RepL PF05732.6 KII65553.1 - 0.034 13.3 0.2 0.059 12.5 0.1 1.4 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) DUF4448 PF14610.1 KII65556.1 - 0.034 13.6 0.0 0.16 11.4 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) BPD_transp_1 PF00528.17 KII65560.1 - 0.0054 16.2 2.0 0.0071 15.8 1.4 1.1 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Yip1 PF04893.12 KII65560.1 - 0.012 15.0 1.7 0.017 14.6 1.2 1.2 1 0 0 1 1 1 0 Yip1 domain HemY_N PF07219.8 KII65560.1 - 0.063 12.8 1.5 0.27 10.7 0.1 2.0 2 0 0 2 2 2 0 HemY protein N-terminus DUF1980 PF09323.5 KII65560.1 - 0.24 11.1 4.1 0.3 10.8 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4064 PF13273.1 KII65560.1 - 0.39 10.8 5.6 0.52 10.4 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) zf-DHHC PF01529.15 KII65560.1 - 1.1 8.6 7.3 1.4 8.2 5.1 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase Claudin_3 PF06653.6 KII65560.1 - 1.2 8.8 6.8 1.6 8.4 4.7 1.1 1 0 0 1 1 1 0 Tight junction protein, Claudin-like Sigma_reg_N PF13800.1 KII65560.1 - 1.7 8.7 6.6 0.88 9.6 0.6 2.2 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF805 PF05656.9 KII65560.1 - 3.9 7.3 6.0 2.7 7.8 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF805) ODV-E18 PF10717.4 KII65560.1 - 4.3 6.8 7.4 0.53 9.7 1.0 2.0 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 AA_permease_2 PF13520.1 KII65561.1 - 4.3e-46 157.3 54.0 5.4e-46 156.9 37.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII65561.1 - 2.3e-23 82.3 46.0 3e-23 81.9 31.9 1.1 1 0 0 1 1 1 1 Amino acid permease Annexin PF00191.15 KII65563.1 - 9.7e-16 57.4 3.3 9.2e-05 22.2 0.0 3.3 3 0 0 3 3 3 3 Annexin EGF_2 PF07974.8 KII65564.1 - 0.05 13.7 10.9 0.05 13.7 7.5 3.5 3 1 0 3 3 3 0 EGF-like domain Imm40 PF15582.1 KII65564.1 - 0.086 11.5 0.0 0.093 11.4 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 40 MAP65_ASE1 PF03999.7 KII65565.1 - 1.1e-38 133.3 48.7 6.3e-38 130.7 31.0 2.4 1 1 1 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) Peptidase_S46 PF10459.4 KII65565.1 - 0.61 8.4 6.6 0.21 9.9 2.8 1.6 2 0 0 2 2 2 0 Peptidase S46 DUF1235 PF06822.7 KII65567.1 - 0.046 12.6 0.0 0.053 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) DDE_Tnp_IS1595 PF12762.2 KII65568.1 - 0.026 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 ISXO2-like transposase domain Crust_neurohorm PF01147.12 KII65568.1 - 0.097 11.9 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family Pox_A_type_inc PF04508.7 KII65569.1 - 0.046 13.4 2.2 2.5 8.1 0.1 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF2576 PF10845.3 KII65569.1 - 0.41 9.8 4.0 2.1 7.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2576) RVP PF00077.15 KII65570.1 - 5.7e-06 26.1 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII65570.1 - 0.00035 21.0 0.0 0.00094 19.6 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII65570.1 - 0.0006 19.6 2.7 0.0006 19.6 1.9 2.2 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.1 KII65570.1 - 0.001 18.6 11.8 0.0039 16.8 1.8 3.0 3 0 0 3 3 3 2 Zinc knuckle gag-asp_proteas PF13975.1 KII65570.1 - 0.003 17.3 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.12 KII65570.1 - 0.051 13.6 0.0 1.3 9.1 0.0 2.5 1 1 1 2 2 2 0 Retrotransposon gag protein MCM PF00493.18 KII65571.1 - 3.8e-109 364.5 1.6 1.3e-84 283.8 0.8 2.2 1 1 1 2 2 2 2 MCM2/3/5 family Mg_chelatase PF01078.16 KII65571.1 - 3e-08 33.0 0.0 7.1e-08 31.8 0.0 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 KII65571.1 - 0.0052 16.2 0.0 0.012 15.0 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 KII65571.1 - 0.015 14.8 0.0 0.043 13.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Fer2_BFD PF04324.10 KII65571.1 - 0.028 14.4 0.0 0.14 12.1 0.0 2.2 1 0 0 1 1 1 0 BFD-like [2Fe-2S] binding domain Mg_chelatase_2 PF13335.1 KII65571.1 - 0.05 14.0 0.1 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KII65571.1 - 0.089 12.5 0.1 2.6 7.7 0.0 3.0 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) MCM_N PF14551.1 KII65572.1 - 3.6e-11 43.5 0.2 4.4e-11 43.3 0.2 1.1 1 0 0 1 1 1 1 MCM N-terminal domain HTH_23 PF13384.1 KII65573.1 - 0.0035 16.9 0.9 0.12 12.0 0.1 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII65573.1 - 0.0036 17.3 0.2 0.0081 16.2 0.1 1.6 1 0 0 1 1 1 1 Transposase DDE_3 PF13358.1 KII65573.1 - 0.0036 17.0 0.0 0.0076 15.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_5 PF01022.15 KII65573.1 - 0.0056 16.3 0.3 0.022 14.4 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_28 PF13518.1 KII65573.1 - 0.0078 16.1 0.7 0.019 14.9 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_38 PF13936.1 KII65573.1 - 0.0093 15.4 3.2 0.8 9.3 0.1 3.0 3 0 0 3 3 3 2 Helix-turn-helix domain DUF1662 PF07878.6 KII65573.1 - 0.043 13.5 0.3 0.11 12.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1662) HTH_7 PF02796.10 KII65573.1 - 0.11 12.3 0.3 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Trp_repressor PF01371.14 KII65573.1 - 0.35 10.8 2.3 0.29 11.0 0.5 1.7 2 0 0 2 2 2 0 Trp repressor protein rve PF00665.21 KII65574.1 - 1.2e-23 83.5 0.0 3.7e-23 81.9 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII65574.1 - 1.8e-15 56.9 0.0 6.5e-15 55.0 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII65574.1 - 2.9e-05 23.9 0.0 7.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII65574.1 - 0.0017 18.8 0.0 0.0048 17.3 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII65574.1 - 0.0022 17.8 2.7 0.0022 17.8 1.9 2.1 2 0 0 2 2 2 1 Zinc knuckle rve_3 PF13683.1 KII65574.1 - 0.0024 17.3 0.0 0.006 16.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.1 KII65574.1 - 0.0084 15.7 10.7 0.014 15.0 1.8 2.9 2 0 0 2 2 2 1 Zinc knuckle gag-asp_proteas PF13975.1 KII65574.1 - 0.012 15.3 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DDE_Tnp_IS1595 PF12762.2 KII65575.1 - 4.1e-08 33.1 0.2 6.9e-08 32.4 0.1 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Tho2 PF11262.3 KII65576.1 - 9.6e-53 179.1 14.9 9.6e-53 179.1 10.3 2.3 3 0 0 3 3 3 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 KII65576.1 - 4.9e-15 55.0 0.2 4.9e-15 55.0 0.1 2.7 3 0 0 3 3 3 1 Transcription- and export-related complex subunit MULE PF10551.4 KII65578.1 - 1.6e-07 31.3 0.0 3e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 MULE transposase domain JAB PF01398.16 KII65579.1 - 3.5e-05 23.5 0.8 0.00067 19.3 0.6 2.6 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DPCD PF14913.1 KII65580.1 - 6.4e-50 168.9 4.0 1.7e-49 167.5 2.8 1.8 1 0 0 1 1 1 1 DPCD protein family rve PF00665.21 KII65580.1 - 8e-18 64.6 0.3 3.4e-16 59.4 0.1 3.3 2 1 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII65580.1 - 1.8e-05 24.1 0.2 7e-05 22.2 0.1 2.0 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII65580.1 - 0.00081 19.2 2.4 0.0022 17.8 1.7 1.8 1 0 0 1 1 1 1 Zinc knuckle DUF993 PF06187.6 KII65580.1 - 0.014 13.9 0.0 0.023 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF993) Shugoshin_N PF07558.6 KII65580.1 - 0.089 12.5 3.8 0.22 11.2 2.6 1.7 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region JAB PF01398.16 KII65581.1 - 2e-24 85.5 0.3 4.5e-24 84.3 0.1 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 KII65581.1 - 6.3e-15 55.2 0.1 1.2e-14 54.4 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 KII65581.1 - 0.00019 20.9 0.0 0.00032 20.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain PALP PF00291.20 KII65583.1 - 7e-34 117.4 0.0 8.2e-34 117.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DFP PF04127.10 KII65583.1 - 0.0043 16.6 0.0 0.0059 16.2 0.0 1.2 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein G6PD_bact PF10786.4 KII65588.1 - 0.047 13.1 0.3 0.065 12.6 0.2 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Kelch_6 PF13964.1 KII65589.1 - 3.3e-18 65.0 14.0 9.7e-05 22.3 0.2 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII65589.1 - 1.2e-14 53.8 16.5 0.00076 19.2 0.1 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KII65589.1 - 2.1e-14 53.1 7.6 0.011 15.8 0.1 5.9 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII65589.1 - 5.6e-09 35.4 16.5 0.02 14.4 0.0 6.4 6 1 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 KII65589.1 - 2e-05 24.1 6.0 2.7 7.8 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.1 KII65589.1 - 0.0043 16.9 15.8 6.5 6.8 0.2 5.7 6 0 0 6 6 6 3 Kelch motif FBA_3 PF08268.7 KII65589.1 - 0.019 14.6 0.3 0.069 12.8 0.0 2.1 2 1 0 2 2 2 0 F-box associated domain DDE_Tnp_IS1595 PF12762.2 KII65593.1 - 4.6e-24 84.9 0.0 6.8e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_ribbon_recom PF13408.1 KII65593.1 - 0.0044 17.2 7.2 0.013 15.7 5.0 1.7 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain DDE_Tnp_IS66 PF03050.9 KII65593.1 - 0.063 12.4 0.0 0.13 11.4 0.0 1.6 2 0 0 2 2 2 0 Transposase IS66 family Zn_Tnp_IS1595 PF12760.2 KII65593.1 - 0.15 11.8 0.4 0.15 11.8 0.2 2.0 2 0 0 2 2 2 0 Transposase zinc-ribbon domain ParB PF08775.5 KII65596.1 - 0.0014 18.9 0.4 0.0018 18.5 0.3 1.2 1 0 0 1 1 1 1 ParB family NolV PF06635.7 KII65596.1 - 0.031 13.4 0.0 0.051 12.7 0.0 1.3 1 1 0 1 1 1 0 Nodulation protein NolV P22_AR_N PF10547.4 KII65596.1 - 0.11 12.3 0.5 0.15 11.8 0.4 1.2 1 0 0 1 1 1 0 P22_AR N-terminal domain Tetraspannin PF00335.15 KII65597.1 - 0.0001 21.6 25.3 0.00022 20.5 17.5 1.7 1 1 0 1 1 1 1 Tetraspanin family zf-DHHC PF01529.15 KII65597.1 - 8.5 5.7 9.7 2.5e+02 0.9 6.7 2.2 1 1 0 1 1 1 0 DHHC palmitoyltransferase DUF4573 PF15140.1 KII65598.1 - 0.00073 19.1 32.2 0.005 16.4 7.2 3.5 1 1 2 4 4 4 3 Domain of unknown function (DUF4573) Cullin PF00888.17 KII65599.1 - 2.6e-49 168.2 26.9 3.3e-49 167.9 18.7 1.0 1 0 0 1 1 1 1 Cullin family OATP PF03137.15 KII65600.1 - 4.7e-36 123.9 16.0 8.3e-36 123.1 11.1 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII65600.1 - 1.8e-15 56.5 5.8 2.7e-15 55.9 4.0 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 KII65600.1 - 0.00099 18.6 0.9 0.00099 18.6 0.6 2.9 3 1 1 4 4 4 1 Ion channel regulatory protein UNC-93 7TMR-DISM_7TM PF07695.6 KII65600.1 - 0.0012 18.5 7.4 0.0012 18.5 5.2 2.3 2 1 0 2 2 2 1 7TM diverse intracellular signalling Caenor_Her-1 PF09232.5 KII65600.1 - 0.16 12.0 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Caenorhabditis elegans Her-1 PIRT PF15099.1 KII65600.1 - 0.18 10.9 1.7 0.36 10.0 1.2 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Neurensin PF14927.1 KII65600.1 - 4 6.8 5.7 2.7 7.3 0.4 2.9 2 2 2 4 4 4 0 Neurensin Tfb2 PF03849.9 KII65601.1 - 6.1e-48 163.3 5.3 8.9e-48 162.7 3.7 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 KII65601.1 - 0.0055 16.4 0.0 0.014 15.1 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ESPR PF13018.1 KII65602.1 - 0.35 10.5 1.7 0.47 10.1 0.5 1.8 2 0 0 2 2 2 0 Extended Signal Peptide of Type V secretion system UQ_con PF00179.21 KII65603.1 - 2.8e-29 101.3 0.0 1.8e-27 95.4 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme Serpin PF00079.15 KII65604.1 - 2.7e-14 53.1 0.1 2.9e-14 52.9 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII65605.1 - 4.9e-19 68.7 0.0 5.8e-19 68.4 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Acetyltransf_4 PF13420.1 KII65605.1 - 0.054 13.4 0.6 0.11 12.4 0.3 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Serpin PF00079.15 KII65606.1 - 7.3e-10 38.5 0.0 8e-10 38.3 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Acetyltransf_4 PF13420.1 KII65606.1 - 0.025 14.5 0.2 0.036 14.0 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-HIT PF04438.11 KII65607.1 - 2.4e-05 23.8 12.9 2.4e-05 23.8 8.9 2.2 2 0 0 2 2 2 1 HIT zinc finger zf-MYND PF01753.13 KII65607.1 - 2.6 7.9 12.2 5.2 7.0 8.5 1.5 1 0 0 1 1 1 0 MYND finger zf-B_box PF00643.19 KII65607.1 - 9.2 6.2 11.2 4.4 7.2 6.1 1.8 1 1 1 2 2 2 0 B-box zinc finger Astacin PF01400.19 KII65608.1 - 2.9e-46 157.2 1.6 4.1e-46 156.7 1.1 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.19 KII65608.1 - 0.76 9.4 5.0 5 6.8 0.1 2.5 1 1 0 2 2 2 0 Matrixin ALIX_LYPXL_bnd PF13949.1 KII65610.1 - 0.082 11.8 0.0 0.082 11.8 0.0 1.1 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV DUF1491 PF07372.7 KII65611.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) DUF3399 PF11879.3 KII65613.1 - 0.094 12.9 0.4 0.21 11.8 0.2 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3399) rve PF00665.21 KII65614.1 - 0.002 18.2 0.0 0.0034 17.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65614.1 - 0.033 13.7 0.1 0.082 12.4 0.0 1.8 2 0 0 2 2 2 0 Integrase core domain Kelch_6 PF13964.1 KII65616.1 - 2.8e-14 52.5 8.4 0.00053 20.0 0.1 5.6 4 1 1 5 5 5 3 Kelch motif Kelch_3 PF13415.1 KII65616.1 - 5.1e-08 32.8 4.3 0.01 15.9 0.0 3.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.1 KII65616.1 - 2.8e-06 26.9 11.2 6e-05 22.7 0.1 5.1 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII65616.1 - 8.5e-05 22.1 6.5 0.002 17.8 0.1 4.0 4 0 0 4 4 4 1 Kelch motif CENP-B_dimeris PF09026.5 KII65616.1 - 0.00047 20.3 2.9 0.0034 17.5 2.4 2.0 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Kelch_5 PF13854.1 KII65616.1 - 0.00054 19.8 3.6 0.67 9.9 0.0 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.20 KII65616.1 - 0.0019 17.7 18.1 0.22 11.0 0.9 5.7 7 0 0 7 7 7 2 Kelch motif FBA_1 PF07734.8 KII65616.1 - 0.0063 16.2 0.2 0.048 13.3 0.0 2.2 1 1 1 2 2 2 1 F-box associated Nucleoplasmin PF03066.10 KII65616.1 - 0.014 14.9 1.9 0.022 14.2 1.3 1.3 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 KII65616.1 - 0.11 12.0 0.3 0.19 11.3 0.2 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2457 PF10446.4 KII65616.1 - 4.2 5.9 8.6 5.7 5.5 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.1 KII65616.1 - 5.4 7.3 8.7 10 6.5 6.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Kelch_3 PF13415.1 KII65617.1 - 6.5e-05 22.9 0.0 0.00013 21.9 0.0 1.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII65617.1 - 0.0013 18.7 0.1 0.023 14.8 0.0 2.3 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.1 KII65617.1 - 0.0032 17.2 0.2 0.0081 15.9 0.1 1.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII65618.1 - 1.1e-16 60.2 2.8 4.1e-06 26.7 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII65618.1 - 4.7e-10 39.3 4.3 0.0013 18.8 0.0 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII65618.1 - 1.5e-08 34.2 8.7 0.023 14.4 0.1 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII65618.1 - 2.4e-06 26.9 9.4 0.0052 16.3 0.2 4.1 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII65618.1 - 0.0021 17.9 1.5 2.6 8.1 0.0 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.10 KII65618.1 - 0.015 15.0 3.7 4.1 7.3 0.0 3.5 3 1 0 3 3 3 0 Kelch motif RabGAP-TBC PF00566.13 KII65621.1 - 0.11 11.9 3.7 0.11 11.9 0.2 2.3 1 1 1 2 2 2 0 Rab-GTPase-TBC domain Phage_connect_1 PF05135.8 KII65621.1 - 0.12 12.5 1.0 2.6 8.2 0.0 2.8 3 0 0 3 3 3 0 Phage gp6-like head-tail connector protein Cnd1 PF12717.2 KII65622.1 - 0.0051 16.6 0.8 0.01 15.6 0.5 1.7 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Kelch_3 PF13415.1 KII65625.1 - 1.2e-09 38.0 11.3 0.006 16.7 0.0 6.0 5 2 1 6 6 6 2 Galactose oxidase, central domain Kelch_6 PF13964.1 KII65625.1 - 4.3e-08 32.9 8.5 0.47 10.7 0.1 5.2 3 2 1 4 4 4 4 Kelch motif Kelch_4 PF13418.1 KII65625.1 - 3.9e-07 29.7 12.6 1.6 8.5 0.0 6.6 6 1 1 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII65625.1 - 0.00011 21.8 2.4 0.53 10.1 0.0 4.9 4 1 0 4 4 4 1 Kelch motif Kelch_1 PF01344.20 KII65625.1 - 0.016 14.7 13.4 0.38 10.3 0.1 5.2 5 1 0 5 5 5 0 Kelch motif Tropomyosin PF00261.15 KII65626.1 - 0.044 12.8 4.5 0.062 12.3 3.1 1.3 1 0 0 1 1 1 0 Tropomyosin CMV_1a PF12467.3 KII65626.1 - 0.58 10.5 7.3 0.87 9.9 5.1 1.3 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family Uds1 PF15456.1 KII65626.1 - 2.6 8.0 7.2 6.3 6.8 5.1 1.6 1 1 0 1 1 1 0 Up-regulated During Septation Retrotrans_gag PF03732.12 KII65627.1 - 0.008 16.2 0.5 0.015 15.3 0.2 1.6 1 1 1 2 2 2 1 Retrotransposon gag protein OGFr_N PF04664.8 KII65627.1 - 0.012 14.9 1.4 0.012 14.9 1.0 1.1 1 0 0 1 1 1 0 Opioid growth factor receptor (OGFr) conserved region ERK-JNK_inhib PF15002.1 KII65627.1 - 0.48 9.7 4.7 1.1 8.6 0.2 2.1 1 1 1 2 2 2 0 ERK and JNK pathways, inhibitor AT_hook PF02178.14 KII65629.1 - 0.86 9.4 7.7 1.7 8.5 5.4 1.6 1 0 0 1 1 1 0 AT hook motif TMF_TATA_bd PF12325.3 KII65631.1 - 0.0065 16.1 17.7 0.015 15.0 7.9 2.6 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding NPV_P10 PF05531.7 KII65631.1 - 0.069 13.4 10.2 3.3 8.0 1.4 3.9 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.1 KII65631.1 - 0.078 13.4 10.5 0.71 10.3 0.3 3.6 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) WD40_alt PF14077.1 KII65631.1 - 0.079 12.6 2.6 2.2 7.9 0.0 2.8 2 0 0 2 2 2 0 Alternative WD40 repeat motif HlyD PF00529.15 KII65631.1 - 0.087 12.1 0.8 0.13 11.5 0.5 1.3 1 1 0 1 1 1 0 HlyD family secretion protein DUF869 PF05911.6 KII65631.1 - 0.38 8.9 17.8 0.24 9.5 6.5 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF869) Tropomyosin_1 PF12718.2 KII65631.1 - 0.49 10.2 23.4 1.3 8.8 8.4 2.8 2 2 0 2 2 2 0 Tropomyosin like Phasin PF05597.6 KII65631.1 - 0.56 9.9 5.7 3.9 7.2 0.0 3.0 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) LMSTEN PF07988.7 KII65631.1 - 0.58 9.4 5.6 1.2 8.4 3.9 1.5 1 0 0 1 1 1 0 LMSTEN motif CHDCT2 PF08074.6 KII65631.1 - 0.79 9.4 5.9 0.36 10.5 1.1 2.3 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain MtrG PF04210.8 KII65631.1 - 1.4 8.6 4.4 1.2 8.8 0.1 2.6 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Complex1_LYR PF05347.10 KII65631.1 - 1.7 8.5 8.3 6.2 6.7 0.1 3.6 4 0 0 4 4 4 0 Complex 1 protein (LYR family) IncA PF04156.9 KII65631.1 - 2 7.9 28.7 3.4 7.2 4.4 3.2 1 1 2 3 3 3 0 IncA protein DivIC PF04977.10 KII65631.1 - 2.1 7.8 18.9 0.7 9.4 0.1 4.3 3 1 0 4 4 4 0 Septum formation initiator cwf21 PF08312.7 KII65631.1 - 2.2 8.1 7.3 0.65 9.8 1.8 2.6 2 1 0 2 2 2 0 cwf21 domain Spc7 PF08317.6 KII65631.1 - 2.7 6.5 23.2 3.6 6.1 2.8 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF2680 PF10925.3 KII65631.1 - 5.5 6.9 6.9 0.46 10.3 0.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2680) zf-UBR PF02207.15 KII65634.1 - 2.9e-12 46.1 20.2 2.9e-12 46.1 14.0 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) F_actin_bind PF08919.5 KII65634.1 - 0.029 14.0 0.2 0.27 10.9 0.1 2.5 2 0 0 2 2 2 0 F-actin binding DNA_primase_lrg PF04104.9 KII65637.1 - 0.025 13.8 1.5 0.16 11.1 0.3 2.2 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit RVT_1 PF00078.22 KII65639.1 - 2.9e-06 26.8 0.0 3.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BNR PF02012.15 KII65640.1 - 0.06 13.1 1.5 4.8 7.4 0.1 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII65641.1 - 3.5e-07 30.0 9.2 3.5e-07 30.0 6.4 2.8 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF1759 PF03564.10 KII65642.1 - 0.11 12.3 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1759) MFS_1 PF07690.11 KII65646.1 - 4.3e-35 121.0 25.4 4.3e-35 121.0 17.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 KII65646.1 - 0.028 14.4 0.4 0.028 14.4 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1228) DUF4538 PF15061.1 KII65646.1 - 0.46 9.8 0.0 0.46 9.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4538) Herpes_UL46 PF03387.9 KII65647.1 - 0.066 11.4 0.0 0.085 11.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL46 protein CH PF00307.26 KII65648.1 - 1.9e-36 124.3 0.1 1.8e-17 63.2 0.0 3.4 3 0 0 3 3 3 2 Calponin homology (CH) domain Spectrin PF00435.16 KII65648.1 - 8.5e-28 96.7 16.8 7.6e-08 32.5 0.3 4.6 4 0 0 4 4 4 4 Spectrin repeat EFhand_Ca_insen PF08726.5 KII65648.1 - 1.8e-14 53.4 0.0 1.3e-13 50.6 0.0 2.7 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.3 KII65648.1 - 3e-07 30.0 0.0 3e-05 23.5 0.0 2.9 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_7 PF13499.1 KII65648.1 - 0.00043 20.3 2.2 0.0013 18.8 0.6 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KII65648.1 - 0.0014 17.7 2.1 0.0074 15.5 0.0 3.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KII65648.1 - 0.049 13.5 6.3 4.8 7.3 0.0 4.0 3 0 0 3 3 3 0 EF-hand domain TMP_2 PF06791.8 KII65648.1 - 0.17 11.4 1.6 23 4.5 0.0 3.2 3 0 0 3 3 3 0 Prophage tail length tape measure protein CH PF00307.26 KII65650.1 - 2.9e-31 107.7 0.0 1.6e-15 57.0 0.0 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KII65650.1 - 1.2e-09 37.6 0.0 5.4e-06 25.9 0.0 2.6 2 1 0 2 2 2 2 CAMSAP CH domain PAPS_reduct PF01507.14 KII65651.1 - 1.3e-20 73.9 0.1 1.1e-17 64.4 0.1 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family YhfH PF14149.1 KII65651.1 - 0.18 11.6 0.7 1.5 8.6 0.5 2.3 2 0 0 2 2 2 0 YhfH-like protein PAP_assoc PF03828.14 KII65652.1 - 0.005 16.7 0.2 0.028 14.3 0.1 2.4 1 1 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 KII65652.1 - 0.038 14.3 0.0 0.16 12.2 0.0 2.2 1 0 0 1 1 1 0 Nucleotidyltransferase domain CD99L2 PF12301.3 KII65653.1 - 0.082 12.5 0.3 0.11 12.1 0.2 1.2 1 0 0 1 1 1 0 CD99 antigen like protein 2 TetR_C_8 PF14278.1 KII65653.1 - 0.14 12.5 0.7 0.35 11.2 0.5 1.9 1 1 0 1 1 1 0 Transcriptional regulator C-terminal region Spc97_Spc98 PF04130.8 KII65656.1 - 2.3e-20 72.4 0.1 2.9e-20 72.1 0.0 1.0 1 0 0 1 1 1 1 Spc97 / Spc98 family Spc97_Spc98 PF04130.8 KII65657.1 - 6.9e-17 60.9 8.2 1.5e-13 49.9 0.8 2.8 2 1 1 3 3 3 2 Spc97 / Spc98 family YlbE PF14003.1 KII65657.1 - 0.012 15.7 0.6 0.36 10.9 0.0 2.5 1 1 0 2 2 2 0 YlbE-like protein I_LWEQ PF01608.12 KII65658.1 - 1.7e-15 57.3 0.3 1.7e-15 57.3 0.2 3.3 3 1 0 3 3 3 1 I/LWEQ domain DUF4250 PF14056.1 KII65658.1 - 0.096 12.4 2.0 1.8 8.3 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) DUF484 PF04340.7 KII65658.1 - 0.17 11.3 10.7 0.25 10.7 2.9 2.9 2 1 1 3 3 3 0 Protein of unknown function, DUF484 ATG16 PF08614.6 KII65658.1 - 0.2 11.4 27.1 0.016 15.0 12.0 3.0 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) CCDC155 PF14662.1 KII65658.1 - 0.3 10.6 22.8 0.18 11.3 13.7 2.2 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 KLRAQ PF10205.4 KII65658.1 - 1.7 8.6 14.4 3.6 7.6 1.2 3.1 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein Reo_sigmaC PF04582.7 KII65658.1 - 2.2 7.3 15.9 0.34 10.0 3.6 2.9 3 1 0 3 3 3 0 Reovirus sigma C capsid protein PRCC PF10253.4 KII65659.1 - 1.5e-07 32.3 0.1 1.9e-07 31.9 0.1 1.2 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting DUF2305 PF10230.4 KII65660.1 - 0.16 11.3 1.5 1.8 7.9 0.0 2.0 1 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) Gemini_AL3 PF01407.12 KII65661.1 - 0.0062 15.9 2.1 0.0075 15.7 1.4 1.2 1 0 0 1 1 1 1 Geminivirus AL3 protein DUF2804 PF10974.3 KII65661.1 - 0.039 12.7 0.3 0.044 12.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2804) DUF3627 PF12299.3 KII65664.1 - 0.078 13.0 0.4 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3627) CBM_48 PF02922.13 KII65666.1 - 0.0002 21.3 0.0 0.00042 20.3 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.13 KII65667.1 - 4.3e-18 65.2 0.2 9.7e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Clathrin PF00637.15 KII65668.1 - 2e-149 491.1 49.1 2.8e-26 91.8 3.9 8.3 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.1 KII65668.1 - 1e-13 50.9 0.1 6.1e-13 48.4 0.1 2.5 2 0 0 2 2 2 1 Clathrin-H-link Coatomer_WDAD PF04053.9 KII65668.1 - 1.2e-07 30.9 4.4 0.0049 15.7 0.0 4.0 4 0 0 4 4 4 2 Coatomer WD associated region Clathrin_propel PF01394.15 KII65668.1 - 6.2e-07 29.3 2.4 2.9 8.3 0.2 4.9 4 0 0 4 4 4 3 Clathrin propeller repeat TPR_7 PF13176.1 KII65668.1 - 1.3e-05 24.6 0.3 4.4 7.3 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 KII65668.1 - 4.8e-05 23.6 0.1 10 6.5 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII65668.1 - 0.017 14.7 7.8 9.5 6.0 0.0 7.0 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII65668.1 - 0.37 10.4 12.0 12 5.6 0.5 6.2 6 1 0 6 6 6 0 TPR repeat zf-U1 PF06220.7 KII65669.1 - 2.7e-21 74.8 4.4 3.9e-21 74.3 3.1 1.2 1 0 0 1 1 1 1 U1 zinc finger zf-met PF12874.2 KII65669.1 - 1.7 8.9 6.4 10 6.4 4.5 2.0 1 1 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KII65669.1 - 9.2 6.5 11.4 64 3.8 7.9 2.0 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding LIM PF00412.17 KII65670.1 - 2.3e-26 91.6 49.1 4.8e-11 42.5 7.5 3.2 2 1 0 3 3 3 3 LIM domain Sgf11 PF08209.6 KII65670.1 - 1.4 8.3 0.0 1.4 8.3 0.0 6.4 7 0 0 7 7 7 0 Sgf11 (transcriptional regulation protein) PDZ PF00595.19 KII65671.1 - 5.1e-10 39.4 0.1 1.5e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII65671.1 - 2.3e-05 24.1 0.0 7.1e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain HTH_Tnp_Tc5 PF03221.11 KII65672.1 - 3.3e-10 39.6 0.1 9.5e-10 38.1 0.0 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_3 PF01381.17 KII65672.1 - 0.024 14.4 0.1 0.046 13.5 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix Apc9 PF12856.2 KII65672.1 - 0.13 12.3 0.3 1 9.4 0.1 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 9 MULE PF10551.4 KII65673.1 - 8.6e-05 22.6 0.1 0.00023 21.2 0.1 1.8 1 0 0 1 1 1 1 MULE transposase domain PDZ PF00595.19 KII65674.1 - 2.7e-09 37.0 0.2 4.6e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII65674.1 - 3e-05 23.8 0.1 6.4e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PurA PF04845.8 KII65675.1 - 2.5e-09 36.5 0.2 0.00023 20.3 0.0 2.1 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein DUF4215 PF13948.1 KII65675.1 - 0.072 13.3 0.5 0.15 12.2 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) PurA PF04845.8 KII65676.1 - 2.7e-05 23.3 0.1 3.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein DUF4215 PF13948.1 KII65676.1 - 0.049 13.8 0.5 0.11 12.7 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) Homeobox PF00046.24 KII65678.1 - 1.2e-21 76.0 1.9 2.7e-21 74.9 1.3 1.6 1 0 0 1 1 1 1 Homeobox domain Rad21_Rec8_N PF04825.8 KII65679.1 - 3.9e-08 33.2 0.2 9.4e-08 31.9 0.1 1.7 1 1 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein TPR_11 PF13414.1 KII65680.1 - 1.1e-10 41.0 5.6 5.2e-07 29.2 0.5 3.2 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 KII65680.1 - 9.1e-10 37.7 3.3 2.9e-05 23.4 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KII65680.1 - 4e-09 35.7 2.1 0.0001 21.9 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 KII65680.1 - 3.3e-07 29.9 2.5 0.064 13.4 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII65680.1 - 5.6e-07 28.8 1.1 0.00013 21.5 0.1 3.5 2 1 1 3 3 2 1 Tetratricopeptide repeat ChAPs PF09295.5 KII65680.1 - 0.0013 17.5 0.3 0.0025 16.6 0.2 1.5 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_16 PF13432.1 KII65680.1 - 0.0022 18.6 0.1 0.011 16.3 0.0 2.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KII65680.1 - 0.0025 17.6 2.8 0.083 12.8 0.1 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KII65680.1 - 0.01 16.4 0.1 2 9.2 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII65680.1 - 0.011 15.4 2.3 2.7 7.9 0.0 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 KII65680.1 - 0.5 10.7 2.8 20 5.5 0.2 3.2 1 1 2 3 3 3 0 Tetratricopeptide repeat Ribosomal_S18 PF01084.15 KII65681.1 - 0.00084 19.1 0.0 0.0022 17.8 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S18 Pox_A12 PF04651.8 KII65683.1 - 0.17 12.0 5.8 0.24 11.4 4.0 1.3 1 0 0 1 1 1 0 Poxvirus A12 protein UPF0560 PF10577.4 KII65683.1 - 0.23 9.6 7.1 0.27 9.4 4.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Apt1 PF10351.4 KII65683.1 - 4 6.1 7.9 4.3 6.0 5.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Yippee-Mis18 PF03226.9 KII65684.1 - 3.8e-15 55.6 0.9 5.1e-15 55.2 0.6 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Intron_maturas2 PF01348.16 KII65684.1 - 0.13 12.1 0.0 0.13 12.1 0.0 1.4 2 0 0 2 2 2 0 Type II intron maturase FRG1 PF06229.7 KII65685.1 - 1.1e-38 132.5 0.2 1.1e-38 132.5 0.1 1.5 2 0 0 2 2 2 1 FRG1-like family Fascin PF06268.8 KII65685.1 - 9.4e-14 51.4 0.7 8.5e-13 48.3 0.4 2.2 1 1 1 2 2 2 1 Fascin domain RicinB_lectin_2 PF14200.1 KII65685.1 - 0.045 14.1 0.0 0.083 13.2 0.0 1.6 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like Bac_surface_Ag PF01103.18 KII65686.1 - 1e-30 107.3 8.2 1.9e-30 106.4 5.6 1.3 1 1 0 1 1 1 1 Surface antigen DUF4138 PF13595.1 KII65686.1 - 0.11 11.4 0.1 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) Clr5 PF14420.1 KII65688.1 - 0.025 14.4 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 Clr5 domain JAB PF01398.16 KII65689.1 - 0.0023 17.6 0.0 0.0038 16.9 0.0 1.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ribosomal_S9 PF00380.14 KII65690.1 - 4.6e-36 123.7 0.0 5.9e-36 123.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Pox_MCEL PF03291.11 KII65692.1 - 0.0022 16.8 0.1 0.0037 16.1 0.1 1.3 1 0 0 1 1 1 1 mRNA capping enzyme FANCI_S3 PF14677.1 KII65692.1 - 0.025 13.9 0.1 0.041 13.2 0.1 1.3 1 0 0 1 1 1 0 FANCI solenoid 3 ABC_tran PF00005.22 KII65693.1 - 1.7e-26 93.1 0.0 2.6e-25 89.3 0.0 2.1 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KII65693.1 - 1.4e-05 25.2 0.8 0.047 13.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain cobW PF02492.14 KII65693.1 - 0.022 14.2 0.0 0.056 12.8 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.14 KII65693.1 - 0.065 12.4 0.1 0.24 10.6 0.1 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 KII65693.1 - 0.074 12.2 0.1 0.16 11.1 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 KII65693.1 - 0.26 12.0 0.0 0.26 12.0 0.0 2.8 3 1 0 3 3 3 0 AAA domain AAA_23 PF13476.1 KII65693.1 - 0.36 11.1 1.4 0.63 10.3 0.4 1.9 2 1 0 2 2 2 0 AAA domain ABC2_membrane PF01061.19 KII65694.1 - 1.1e-41 142.3 24.1 1.1e-41 142.3 16.7 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 KII65694.1 - 0.0013 17.7 22.2 0.0013 17.7 15.4 2.0 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 KII65694.1 - 3.3 6.4 16.7 3.5 6.3 7.3 2.5 1 1 1 2 2 2 0 ABC-2 family transporter protein Amidase PF01425.16 KII65695.1 - 1.1e-41 143.1 0.6 1.3e-41 142.9 0.4 1.0 1 0 0 1 1 1 1 Amidase Amidase PF01425.16 KII65696.1 - 5.1e-10 38.7 0.0 5.7e-10 38.6 0.0 1.0 1 0 0 1 1 1 1 Amidase MULE PF10551.4 KII65697.1 - 0.035 14.2 0.0 0.069 13.3 0.0 1.4 1 0 0 1 1 1 0 MULE transposase domain Amidase PF01425.16 KII65699.1 - 4.7e-29 101.5 0.4 5.5e-29 101.2 0.3 1.0 1 0 0 1 1 1 1 Amidase PMC2NT PF08066.7 KII65700.1 - 0.028 14.6 0.2 0.047 13.9 0.1 1.4 1 0 0 1 1 1 0 PMC2NT (NUC016) domain Amidase PF01425.16 KII65700.1 - 0.11 11.3 0.0 0.78 8.5 0.0 1.7 1 1 1 2 2 2 0 Amidase BCAS2 PF05700.6 KII65701.1 - 3.7e-25 88.7 1.9 4.6e-25 88.3 1.3 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Syntaxin-6_N PF09177.6 KII65701.1 - 0.19 12.1 1.0 0.8 10.1 0.1 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Myb_DNA-bind_4 PF13837.1 KII65701.1 - 0.24 11.5 1.4 0.38 10.9 0.8 1.5 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain UDPGP PF01704.13 KII65702.1 - 1.5e-139 465.1 2.6 2.7e-139 464.3 1.8 1.3 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase CAP PF00188.21 KII65703.1 - 7.9e-52 174.9 10.0 3.8e-16 59.7 1.5 4.2 4 0 0 4 4 4 4 Cysteine-rich secretory protein family DDE_Tnp_IS1595 PF12762.2 KII65705.1 - 9.1e-23 80.7 0.0 2.4e-22 79.3 0.0 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain zf-trcl PF13451.1 KII65706.1 - 0.051 13.2 0.1 0.051 13.2 0.0 1.8 2 0 0 2 2 2 0 Probable zinc-binding domain Amidase PF01425.16 KII65707.1 - 1.9e-09 36.9 0.0 2e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Amidase Amidase PF01425.16 KII65708.1 - 2.2e-05 23.5 0.0 3.1e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Amidase Amidase PF01425.16 KII65709.1 - 1.6e-39 136.0 0.7 1.7e-39 135.9 0.5 1.0 1 0 0 1 1 1 1 Amidase Amidase PF01425.16 KII65710.1 - 1e-08 34.4 0.0 1.1e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Amidase rve PF00665.21 KII65711.1 - 1.3e-17 63.9 0.0 2.5e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65711.1 - 0.00016 21.0 0.0 0.00031 20.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII65711.1 - 0.024 14.6 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.22 KII65712.1 - 2.6e-17 62.9 0.0 1.2e-16 60.7 0.0 2.2 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) 2-oxoacid_dh PF00198.18 KII65713.1 - 2e-77 259.5 1.1 2.6e-77 259.2 0.7 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 KII65713.1 - 4.5e-18 64.6 0.3 9.6e-18 63.6 0.2 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.1 KII65713.1 - 1.3e-06 28.0 0.5 0.00057 19.5 0.0 2.7 1 1 1 2 2 2 2 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.1 KII65713.1 - 1.4e-05 24.6 0.6 0.00075 19.1 0.0 2.5 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.14 KII65713.1 - 0.00017 21.2 1.7 0.0029 17.2 0.2 2.3 1 1 1 2 2 2 1 Glycine cleavage H-protein HlyD_2 PF12700.2 KII65713.1 - 0.012 14.8 4.2 0.022 13.9 0.7 2.6 2 1 1 3 3 3 0 HlyD family secretion protein HlyD PF00529.15 KII65713.1 - 0.017 14.4 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 HlyD family secretion protein DDE_1 PF03184.14 KII65714.1 - 0.039 13.1 0.6 0.38 9.8 0.0 2.3 2 1 0 2 2 2 0 DDE superfamily endonuclease Slx4 PF09494.5 KII65715.1 - 0.084 12.6 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Slx4 endonuclease Med20 PF08612.6 KII65717.1 - 0.00013 21.2 0.0 0.00026 20.2 0.0 1.7 1 1 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex zf-NF-X1 PF01422.12 KII65721.1 - 3.6e-05 23.6 31.3 0.0008 19.3 9.5 14.9 14 3 1 15 15 15 4 NF-X1 type zinc finger DDE_3 PF13358.1 KII65722.1 - 2.4e-11 43.5 0.1 3.9e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease bZIP_1 PF00170.16 KII65723.1 - 3.5e-09 36.4 9.0 5.4e-09 35.8 6.2 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KII65723.1 - 5.1e-09 35.8 10.5 8.7e-09 35.0 7.3 1.3 1 0 0 1 1 1 1 Basic region leucine zipper DUF3450 PF11932.3 KII65723.1 - 0.00031 20.0 1.2 0.00046 19.5 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Striatin PF08232.7 KII65723.1 - 0.00064 20.0 1.0 0.00097 19.4 0.7 1.3 1 0 0 1 1 1 1 Striatin family DDE_Tnp_IS1595 PF12762.2 KII65724.1 - 1.1e-09 38.3 0.0 1.3e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_Tnp_IS1595 PF12760.2 KII65724.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DEAD PF00270.24 KII65725.1 - 2.7e-41 140.8 0.5 6.3e-41 139.6 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII65725.1 - 8.9e-28 95.9 0.0 2.4e-27 94.6 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 KII65725.1 - 0.0002 21.0 0.1 0.00046 19.8 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 KII65725.1 - 0.00069 19.4 0.1 0.0033 17.2 0.1 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 KII65725.1 - 0.0011 18.6 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII65725.1 - 0.0039 17.3 0.0 0.014 15.5 0.0 2.0 1 1 1 2 2 2 1 AAA domain Helicase_RecD PF05127.9 KII65725.1 - 0.036 13.7 0.0 0.07 12.7 0.0 1.5 1 0 0 1 1 1 0 Helicase AAA_25 PF13481.1 KII65725.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.16 KII65725.1 - 0.11 11.8 0.5 0.23 10.7 0.4 1.3 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain PhoH PF02562.11 KII65725.1 - 0.11 11.6 0.7 0.28 10.4 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein DDE_3 PF13358.1 KII65726.1 - 0.013 15.2 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease S-AdoMet_synt_C PF02773.11 KII65727.1 - 7.6e-67 223.2 0.0 1.5e-66 222.3 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 KII65727.1 - 2.8e-44 149.9 0.0 5.6e-44 148.9 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 KII65727.1 - 1.3e-40 137.6 0.6 2.2e-40 136.9 0.4 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain Oxysterol_BP PF01237.13 KII65728.1 - 4.8e-108 360.8 0.0 5.5e-108 360.6 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein FYVE PF01363.16 KII65729.1 - 4.3e-12 45.7 3.3 4.3e-12 45.7 2.3 2.1 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.11 KII65729.1 - 0.00075 19.3 1.9 0.0015 18.3 1.3 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger IBR PF01485.16 KII65729.1 - 0.17 11.7 7.4 0.058 13.2 2.0 2.2 2 0 0 2 2 2 0 IBR domain HypA PF01155.14 KII65729.1 - 5.4 6.7 7.6 4.3 7.0 2.9 2.2 2 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-B_box PF00643.19 KII65729.1 - 6.5 6.7 10.2 3.9 7.4 4.7 2.3 2 1 0 2 2 2 0 B-box zinc finger IF-2B PF01008.12 KII65730.1 - 3.2e-41 141.1 0.0 3.6e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF2371 PF10177.4 KII65730.1 - 0.004 17.0 0.0 0.0066 16.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) DUF1249 PF06853.7 KII65730.1 - 0.067 12.8 0.3 0.2 11.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1249) LRR_6 PF13516.1 KII65733.1 - 5.6e-14 50.6 10.6 0.099 12.7 0.2 9.6 10 0 0 10 10 10 5 Leucine Rich repeat LRR_4 PF12799.2 KII65733.1 - 7.1e-13 47.8 9.1 6.9e-05 22.3 0.0 6.1 4 1 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KII65733.1 - 1.1e-06 27.8 4.8 20 5.7 0.1 8.2 8 1 0 8 8 8 1 Leucine Rich Repeat LRR_8 PF13855.1 KII65733.1 - 0.00022 20.9 16.9 0.027 14.2 0.2 6.2 5 1 1 6 6 6 2 Leucine rich repeat Mucin PF01456.12 KII65734.1 - 0.0029 17.3 13.0 0.0051 16.5 9.0 1.5 1 0 0 1 1 1 1 Mucin-like glycoprotein TMEM154 PF15102.1 KII65734.1 - 0.0036 16.9 8.5 0.0096 15.6 5.9 1.8 1 1 0 1 1 1 1 TMEM154 protein family BPD_transp_1 PF00528.17 KII65734.1 - 0.038 13.4 0.2 0.055 12.9 0.2 1.1 1 0 0 1 1 1 0 Binding-protein-dependent transport system inner membrane component Rifin_STEVOR PF02009.11 KII65734.1 - 0.091 12.3 5.8 0.07 12.7 3.0 1.4 1 1 0 1 1 1 0 Rifin/stevor family DUF2155 PF09923.4 KII65734.1 - 0.37 10.9 2.4 5.6 7.1 0.0 2.8 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2155) DC_STAMP PF07782.8 KII65734.1 - 6.1 6.4 6.5 11 5.5 2.3 2.6 2 1 0 2 2 2 0 DC-STAMP-like protein Ldl_recept_a PF00057.13 KII65736.1 - 1.3e-22 79.4 59.9 8.3e-11 41.6 11.2 3.6 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A G-7-MTase PF12803.2 KII65737.1 - 0.0072 15.5 0.5 0.0095 15.1 0.3 1.2 1 0 0 1 1 1 1 mRNA (guanine-7-)methyltransferase (G-7-MTase) Methyltransf_15 PF09445.5 KII65737.1 - 0.14 11.7 2.6 0.5 9.9 1.8 1.9 1 1 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Ldl_recept_a PF00057.13 KII65739.1 - 3.9e-09 36.2 26.8 1.1e-05 25.2 6.1 3.0 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII65739.1 - 1.4 8.4 9.9 2.4 7.7 6.9 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like SIR2_2 PF13289.1 KII65741.1 - 0.0055 16.5 0.2 0.0081 16.0 0.1 1.4 1 1 0 1 1 1 1 SIR2-like domain bPH_3 PF14470.1 KII65741.1 - 0.16 12.2 1.6 0.53 10.5 1.1 2.2 1 1 0 1 1 1 0 Bacterial PH domain BssC_TutF PF08201.6 KII65744.1 - 0.12 11.8 0.0 0.28 10.6 0.0 1.6 1 0 0 1 1 1 0 BssC/TutF protein SPT16 PF08644.6 KII65745.1 - 1.2 9.0 6.8 0.088 12.6 0.4 2.2 2 1 1 3 3 3 0 FACT complex subunit (SPT16/CDC68) DDE_3 PF13358.1 KII65746.1 - 6.8e-05 22.6 0.0 0.00015 21.5 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Soyouz_module PF14313.1 KII65746.1 - 2.6 7.6 6.1 5.7 6.5 4.2 1.5 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) SSP160 PF06933.6 KII65746.1 - 4.6 5.1 6.9 6.4 4.6 4.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PBS_linker_poly PF00427.16 KII65748.1 - 0.08 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide VanW PF04294.8 KII65748.1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.4 1 1 0 1 1 1 0 VanW like protein DUF912 PF06024.7 KII65750.1 - 0.096 12.7 0.3 0.25 11.4 0.0 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF912 PF06024.7 KII65751.1 - 0.01 15.8 0.3 0.023 14.7 0.2 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) TMEM154 PF15102.1 KII65751.1 - 0.15 11.7 5.0 0.46 10.1 3.4 1.8 1 1 0 1 1 1 0 TMEM154 protein family DUF4094 PF13334.1 KII65753.1 - 0.014 15.7 0.0 0.019 15.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Chordopox_A13L PF05961.6 KII65753.1 - 0.028 14.3 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A13L protein AJAP1_PANP_C PF15298.1 KII65754.1 - 0.00075 19.4 0.1 0.0011 18.9 0.1 1.3 1 0 0 1 1 1 1 AJAP1/PANP C-terminus DUF230 PF03003.11 KII65754.1 - 0.0034 16.9 0.2 0.4 10.2 0.0 2.2 1 1 1 2 2 2 2 Poxvirus proteins of unknown function DUF3902 PF13042.1 KII65754.1 - 0.0063 15.8 0.2 0.012 14.8 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3902) Adeno_hexon_C PF03678.9 KII65754.1 - 0.066 12.6 0.3 0.078 12.4 0.2 1.1 1 0 0 1 1 1 0 Hexon, adenovirus major coat protein, C-terminal domain Sprouty PF05210.8 KII65754.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Sprouty protein (Spry) DUF4381 PF14316.1 KII65754.1 - 0.19 11.8 0.2 0.29 11.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) CENP-B_dimeris PF09026.5 KII65755.1 - 0.0051 17.0 0.4 0.0063 16.7 0.3 1.2 1 0 0 1 1 1 1 Centromere protein B dimerisation domain MSG PF02349.10 KII65755.1 - 0.29 11.1 8.1 1.5 8.8 0.1 2.2 1 1 1 2 2 2 0 Major surface glycoprotein ABA_GPCR PF12430.3 KII65758.1 - 0.059 12.5 0.1 0.08 12.0 0.1 1.2 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor PGA2 PF07543.7 KII65758.1 - 0.092 12.5 0.5 0.12 12.1 0.3 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 SecG PF03840.9 KII65759.1 - 0.02 14.6 2.1 0.032 13.9 1.5 1.3 1 0 0 1 1 1 0 Preprotein translocase SecG subunit DUF2678 PF10856.3 KII65759.1 - 0.03 14.0 0.6 0.046 13.4 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2678) DUF658 PF04936.7 KII65759.1 - 0.085 12.7 0.2 0.13 12.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF658) DUF4501 PF14946.1 KII65759.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) rve PF00665.21 KII65760.1 - 1.3e-10 41.4 0.0 2.8e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain BNR PF02012.15 KII65763.1 - 2e-06 26.7 2.2 0.088 12.6 0.1 3.8 3 0 0 3 3 3 3 BNR/Asp-box repeat Serpin PF00079.15 KII65764.1 - 6.4e-14 51.8 5.1 6.9e-14 51.7 3.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3800 PF12686.2 KII65764.1 - 0.019 14.6 6.2 0.02 14.5 4.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) NGP1NT PF08153.7 KII65767.1 - 1.3e-27 96.3 0.1 2.2e-27 95.5 0.1 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 KII65767.1 - 2.6e-17 62.8 0.3 9.1e-15 54.6 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 KII65767.1 - 7.2e-08 31.8 0.1 3.2e-06 26.5 0.1 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KII65767.1 - 2.1e-06 27.6 0.6 0.0076 16.0 0.1 3.4 2 1 1 3 3 3 1 Dynamin family DUF258 PF03193.11 KII65767.1 - 0.00032 19.9 0.1 0.00066 18.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 KII65767.1 - 0.031 14.7 0.2 0.87 10.0 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein tRNA-synt_1b PF00579.20 KII65768.1 - 1.1e-16 60.7 0.0 1.4e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1b PF00579.20 KII65769.1 - 0.014 14.5 0.0 0.024 13.7 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) DUF1447 PF07288.6 KII65769.1 - 0.093 12.5 0.0 0.26 11.1 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1447) Ribosomal_S15 PF00312.17 KII65772.1 - 7.3e-22 76.9 0.5 1.7e-21 75.7 0.4 1.5 2 0 0 2 2 2 1 Ribosomal protein S15 Ribosomal_S13_N PF08069.7 KII65772.1 - 8.8e-11 41.4 0.0 2.4e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Kelch_4 PF13418.1 KII65773.1 - 5.6e-35 118.8 14.7 5.9e-08 32.3 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 KII65773.1 - 2.6e-34 115.9 18.0 1.3e-08 34.6 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII65773.1 - 5.5e-30 102.6 16.2 1.2e-08 34.3 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 KII65773.1 - 1.9e-28 97.9 7.7 5.6e-08 32.7 0.0 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII65773.1 - 4e-17 61.7 22.1 2.3e-06 27.4 0.4 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KII65773.1 - 1.3e-15 56.4 13.5 6.7e-05 22.4 0.1 6.1 6 0 0 6 6 6 4 Kelch motif rve PF00665.21 KII65774.1 - 0.045 13.8 0.0 0.076 13.1 0.0 1.3 1 1 0 1 1 1 0 Integrase core domain DUF4441 PF14536.1 KII65775.1 - 0.11 12.5 1.3 0.27 11.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) Ocnus PF05005.10 KII65777.1 - 0.062 13.1 0.1 0.087 12.7 0.0 1.1 1 0 0 1 1 1 0 Janus/Ocnus family (Ocnus) Profilin PF00235.14 KII65778.1 - 0.0032 17.5 0.4 0.0035 17.4 0.3 1.1 1 0 0 1 1 1 1 Profilin Lip_prot_lig_C PF10437.4 KII65778.1 - 0.012 15.2 0.4 0.018 14.6 0.3 1.3 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus Toxin_61 PF15538.1 KII65778.1 - 0.14 12.1 0.3 0.17 11.8 0.2 1.2 1 0 0 1 1 1 0 Putative toxin 61 Ribosomal_L1 PF00687.16 KII65780.1 - 5.4e-14 52.0 0.0 6e-14 51.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family TraG_N PF07916.6 KII65781.1 - 1.2e-122 409.7 21.2 1.2e-122 409.7 14.7 3.2 3 0 0 3 3 3 1 TraG-like protein, N-terminal region TraH PF06122.6 KII65781.1 - 5.6e-94 314.9 7.1 5.6e-94 314.9 4.9 3.5 3 0 0 3 3 3 1 Conjugative relaxosome accessory transposon protein Sel1 PF08238.7 KII65782.1 - 1.6e-27 95.3 12.5 1.1e-07 32.2 0.2 5.5 5 0 0 5 5 5 4 Sel1 repeat DUF1955 PF09205.5 KII65782.1 - 0.026 14.0 0.1 0.63 9.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1955) CCDC155 PF14662.1 KII65784.1 - 0.33 10.5 3.7 0.7 9.4 0.3 2.0 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 DUF544 PF04424.8 KII65785.1 - 4.3e-26 91.0 0.3 7.4e-26 90.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF544) DehI PF10778.4 KII65786.1 - 0.0074 15.8 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Halocarboxylic acid dehydrogenase DehI DUF544 PF04424.8 KII65787.1 - 7.3e-26 90.3 0.4 1.3e-25 89.5 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF544) SNAP PF14938.1 KII65788.1 - 2.6e-10 39.9 4.1 3.9e-10 39.3 2.9 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII65788.1 - 0.0076 16.1 1.4 0.036 13.9 0.1 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat NSF PF02071.15 KII65788.1 - 0.034 14.6 3.8 2.8 8.8 0.8 3.7 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.1 KII65788.1 - 0.037 13.8 6.4 0.037 13.8 4.4 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat zf-Paramyx-P PF13008.2 KII65788.1 - 0.069 12.3 1.8 0.21 10.8 1.2 1.9 1 0 0 1 1 1 0 Zinc-binding domain of Paramyxoviridae V protein TPR_1 PF00515.23 KII65788.1 - 0.72 9.5 11.4 0.077 12.6 1.4 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII65788.1 - 2.2 7.9 8.4 0.75 9.4 1.8 2.9 3 1 1 4 4 4 0 TPR repeat TPR_2 PF07719.12 KII65788.1 - 3 7.9 10.5 0.46 10.5 2.3 3.5 4 1 0 4 4 4 0 Tetratricopeptide repeat FHA PF00498.21 KII65789.1 - 0.075 13.1 0.2 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 FHA domain Lipocalin PF00061.18 KII65789.1 - 0.087 12.8 1.0 1.2 9.0 0.3 2.4 1 1 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family DUF2682 PF10909.3 KII65789.1 - 0.13 12.5 1.0 2.5 8.4 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2682) MULE PF10551.4 KII65790.1 - 0.016 15.3 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 MULE transposase domain rve PF00665.21 KII65791.1 - 1.8e-13 50.6 0.0 2.2e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65791.1 - 0.0069 15.8 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Scaffolding_pro PF11418.3 KII65792.1 - 0.026 14.8 0.2 0.04 14.2 0.1 1.4 1 0 0 1 1 1 0 Phi29 scaffolding protein DUF442 PF04273.8 KII65798.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative phosphatase (DUF442) PSP1 PF04468.7 KII65801.1 - 0.055 13.4 0.3 0.072 13.0 0.2 1.2 1 0 0 1 1 1 0 PSP1 C-terminal conserved region ACR_tran PF00873.14 KII65801.1 - 0.064 10.6 0.0 0.072 10.4 0.0 1.0 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family CHCH PF06747.8 KII65802.1 - 0.13 12.2 0.7 0.29 11.1 0.5 1.6 1 0 0 1 1 1 0 CHCH domain HSBP1 PF06825.7 KII65805.1 - 0.0042 16.6 1.7 1.7 8.2 0.1 2.4 2 0 0 2 2 2 2 Heat shock factor binding protein 1 Ter PF05472.6 KII65805.1 - 0.0093 15.1 0.4 1.5 7.8 0.0 2.1 2 0 0 2 2 2 2 DNA replication terminus site-binding protein (Ter protein) Proteasom_Rpn13 PF04683.8 KII65805.1 - 0.022 14.8 0.2 15 5.7 0.0 3.4 4 0 0 4 4 4 0 Proteasome complex subunit Rpn13 ubiquitin receptor gag_pre-integrs PF13976.1 KII65805.1 - 0.055 13.1 0.4 12 5.5 0.1 2.7 2 1 0 2 2 2 0 GAG-pre-integrase domain rve PF00665.21 KII65807.1 - 4.7e-29 100.9 0.0 1.4e-28 99.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII65807.1 - 9.5e-21 74.1 0.1 2.2e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII65807.1 - 3.9e-08 33.1 0.0 1.2e-07 31.5 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.5 KII65807.1 - 3.6e-06 26.2 1.2 9.7e-06 24.9 0.8 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger zf-CCHC PF00098.18 KII65807.1 - 0.0001 22.0 11.8 0.0055 16.5 1.9 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII65807.1 - 0.00053 20.4 0.0 0.0015 19.0 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII65807.1 - 0.0014 18.2 0.1 0.0037 16.8 0.1 1.7 1 1 0 1 1 1 1 Aspartyl protease rve_3 PF13683.1 KII65807.1 - 0.0026 17.2 0.0 0.0088 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_3 PF13917.1 KII65807.1 - 0.01 15.5 5.6 0.033 13.9 0.3 2.5 1 1 1 2 2 2 1 Zinc knuckle Herpes_UL14 PF03580.9 KII65807.1 - 0.053 13.3 0.1 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL14-like protein gag-asp_proteas PF13975.1 KII65807.1 - 0.06 13.1 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII65807.1 - 0.086 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-ribbon_3 PF13248.1 KII65807.1 - 0.18 11.0 4.0 0.4 9.9 2.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-CCHC_4 PF14392.1 KII65807.1 - 7 6.3 12.1 0.35 10.5 0.6 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_5 PF14787.1 KII65807.1 - 8.1 6.0 14.0 0.36 10.3 0.7 3.2 2 1 1 3 3 3 0 GAG-polyprotein viral zinc-finger DDE_3 PF13358.1 KII65808.1 - 0.00015 21.4 0.0 0.0002 21.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease PAN_2 PF08276.6 KII65808.1 - 0.066 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 PAN-like domain Peptidase_M17_N PF02789.12 KII65810.1 - 0.05 13.3 0.0 0.67 9.7 0.0 2.0 1 1 1 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.16 KII65811.1 - 1e-95 320.2 0.0 1.2e-95 320.0 0.0 1.0 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain WD40 PF00400.27 KII65815.1 - 1e-47 158.3 21.8 6.3e-09 35.3 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KII65815.1 - 1.8e-08 33.0 10.2 0.065 11.3 0.1 5.3 1 1 4 5 5 5 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KII65815.1 - 0.00048 18.9 8.6 0.27 9.9 1.1 3.8 1 1 1 2 2 2 2 Nup133 N terminal like zf-C2H2 PF00096.21 KII65820.1 - 1e-17 63.2 47.6 0.00014 22.0 2.8 7.0 6 1 0 6 6 6 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KII65820.1 - 3.1e-13 49.3 21.8 4.9e-07 29.7 1.5 7.4 8 1 0 8 8 7 3 Zinc-finger double domain zf-C2H2_jaz PF12171.3 KII65820.1 - 4.9e-10 39.2 24.1 0.0081 16.2 1.3 5.8 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 KII65820.1 - 2e-09 37.0 43.9 0.0077 16.4 2.1 6.8 6 1 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KII65820.1 - 1.5e-05 24.6 31.8 0.035 13.9 1.3 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-met PF12874.2 KII65820.1 - 0.00079 19.5 30.6 0.71 10.1 0.1 6.4 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-Di19 PF05605.7 KII65820.1 - 0.0096 16.0 8.3 0.0096 16.0 5.8 3.9 3 1 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding RRN7 PF11781.3 KII65820.1 - 0.023 14.1 10.2 1.5 8.3 0.1 4.6 5 0 0 5 5 5 0 RNA polymerase I-specific transcription initiation factor Rrn7 Zn-ribbon_8 PF09723.5 KII65820.1 - 0.35 10.8 27.3 0.19 11.7 2.3 5.3 4 2 0 4 4 4 0 Zinc ribbon domain zf-RING_3 PF14369.1 KII65820.1 - 1 9.4 16.8 0.22 11.5 0.2 5.4 5 1 0 5 5 5 0 zinc-finger Zn_Tnp_IS1595 PF12760.2 KII65820.1 - 2 8.2 21.2 0.053 13.3 1.7 3.8 3 0 0 3 3 3 0 Transposase zinc-ribbon domain PyrI_C PF02748.10 KII65820.1 - 5 6.6 10.3 0.61 9.5 0.2 4.0 4 1 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-FPG_IleRS PF06827.9 KII65820.1 - 5.4 6.7 12.3 0.52 10.0 0.2 4.2 3 1 0 3 3 3 0 Zinc finger found in FPG and IleRS HTH_Tnp_Tc5 PF03221.11 KII65821.1 - 0.00012 21.7 0.0 0.00026 20.7 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF4407 PF14362.1 KII65821.1 - 0.00094 18.2 0.4 0.0011 18.0 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) CDC50 PF03381.10 KII65822.1 - 1.9e-24 86.3 0.3 2.2e-24 86.1 0.2 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DDE_1 PF03184.14 KII65823.1 - 0.0002 20.5 0.1 0.00029 20.0 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Mgr1 PF08602.5 KII65824.1 - 0.023 13.7 0.0 0.03 13.3 0.0 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Peptidase_M49 PF03571.10 KII65825.1 - 0.05 11.6 0.3 0.056 11.5 0.2 1.0 1 0 0 1 1 1 0 Peptidase family M49 zf-C2H2 PF00096.21 KII65828.1 - 0.2 12.0 12.1 1.2 9.6 1.0 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type FLYWCH PF04500.11 KII65830.1 - 0.00073 19.3 2.1 0.0013 18.6 1.5 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain Hormone_4 PF00220.12 KII65830.1 - 0.44 10.3 4.3 2.2 8.1 0.2 2.5 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain DDE_Tnp_IS1595 PF12762.2 KII65832.1 - 0.00015 21.6 0.0 0.00021 21.1 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain TSP_C PF05735.7 KII65833.1 - 0.029 13.9 0.3 0.034 13.6 0.2 1.2 1 0 0 1 1 1 0 Thrombospondin C-terminal region DUF3942 PF13078.1 KII65833.1 - 0.058 13.4 2.7 0.1 12.6 1.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3942) BNR PF02012.15 KII65834.1 - 0.0018 17.8 0.1 14 6.0 0.0 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat PLAC8 PF04749.12 KII65835.1 - 7.2e-15 55.4 9.3 8.5e-15 55.2 6.4 1.1 1 0 0 1 1 1 1 PLAC8 family MVIN PF03023.9 KII65835.1 - 0.038 12.4 0.0 0.043 12.2 0.0 1.0 1 0 0 1 1 1 0 MviN-like protein His_leader PF08047.6 KII65835.1 - 0.39 10.1 1.8 0.67 9.4 1.3 1.3 1 0 0 1 1 1 0 Histidine operon leader peptide PLAC8 PF04749.12 KII65837.1 - 1.2e-08 35.4 11.1 2.8e-08 34.2 7.7 1.7 1 1 0 1 1 1 1 PLAC8 family PLAC8 PF04749.12 KII65838.1 - 1.5e-17 64.0 12.7 2.5e-17 63.3 8.8 1.3 1 1 0 1 1 1 1 PLAC8 family LpxD PF04613.9 KII65839.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD DAN PF03045.10 KII65842.1 - 0.076 12.4 1.0 0.11 11.9 0.7 1.2 1 0 0 1 1 1 0 DAN domain RVP PF00077.15 KII65844.1 - 3.5e-06 26.8 0.1 6.7e-06 25.9 0.0 1.5 2 0 0 2 2 2 1 Retroviral aspartyl protease RVT_1 PF00078.22 KII65847.1 - 0.017 14.5 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Mst1_SARAH PF11629.3 KII65848.1 - 0.042 13.6 0.1 6 6.7 0.0 3.1 3 1 0 3 3 3 0 C terminal SARAH domain of Mst1 Pkinase PF00069.20 KII65849.1 - 3.4e-69 232.8 0.1 7.4e-69 231.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII65849.1 - 2.4e-49 167.7 0.0 3.9e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.3 KII65849.1 - 5.4e-05 22.9 0.7 0.00017 21.3 0.1 2.2 2 0 0 2 2 2 1 C terminal SARAH domain of Mst1 Kinase-like PF14531.1 KII65849.1 - 0.022 13.7 0.0 0.044 12.7 0.0 1.5 1 0 0 1 1 1 0 Kinase-like FliG_N PF14842.1 KII65849.1 - 0.023 14.8 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 FliG N-terminal domain RVP PF00077.15 KII65850.1 - 1.1e-07 31.6 0.0 2.2e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII65850.1 - 0.0038 17.0 5.0 0.0079 16.0 3.5 1.6 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.1 KII65850.1 - 0.068 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII65850.1 - 0.12 12.8 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVT_1 PF00078.22 KII65851.1 - 3.2e-27 95.2 0.2 6.4e-27 94.3 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII65851.1 - 8.2e-24 84.0 0.0 5.6e-23 81.3 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain RVP PF00077.15 KII65851.1 - 3.5e-07 30.0 0.0 8.2e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII65851.1 - 0.04 13.4 0.0 0.13 11.8 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain gag-asp_proteas PF13975.1 KII65851.1 - 0.21 11.4 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVT_1 PF00078.22 KII65852.1 - 3.3e-09 36.4 0.1 8.3e-07 28.5 0.0 2.7 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII65853.1 - 3.2e-12 46.5 0.0 4.8e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII65853.1 - 1.6e-05 24.3 0.0 2.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DUF572 PF04502.8 KII65854.1 - 3e-48 164.7 5.6 3.3e-48 164.5 3.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF866 PF05907.8 KII65854.1 - 0.00091 18.7 0.2 0.001 18.5 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Mu-like_Com PF10122.4 KII65854.1 - 0.006 15.6 0.3 0.27 10.3 0.0 2.3 2 0 0 2 2 2 1 Mu-like prophage protein Com Lar_restr_allev PF14354.1 KII65854.1 - 0.0085 16.3 0.2 0.92 9.8 0.0 2.1 1 1 1 2 2 2 2 Restriction alleviation protein Lar zf-ISL3 PF14690.1 KII65854.1 - 0.012 15.5 0.4 0.16 11.9 0.0 2.2 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 HypA PF01155.14 KII65854.1 - 0.019 14.6 0.1 0.037 13.7 0.1 1.5 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-dskA_traR PF01258.12 KII65854.1 - 0.03 14.0 1.1 0.11 12.2 0.1 2.1 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger DNA_RNApol_7kD PF03604.8 KII65854.1 - 0.069 12.6 1.1 1.9 8.0 0.1 2.4 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit UPF0547 PF10571.4 KII65854.1 - 0.091 12.4 1.8 6.7 6.5 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 CpXC PF14353.1 KII65854.1 - 0.13 12.2 0.2 8.2 6.4 0.0 2.1 2 0 0 2 2 2 0 CpXC protein zf-ribbon_3 PF13248.1 KII65854.1 - 0.2 10.9 4.1 2 7.7 2.8 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Rubredoxin PF00301.15 KII65854.1 - 0.56 10.1 2.5 3.1 7.7 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin DUF572 PF04502.8 KII65855.1 - 4.6e-06 26.0 2.1 5.4e-06 25.8 1.5 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Trm112p PF03966.11 KII65858.1 - 1.3e-11 44.6 0.0 1.5e-11 44.5 0.0 1.0 1 0 0 1 1 1 1 Trm112p-like protein BNR PF02012.15 KII65860.1 - 1.6e-07 30.1 1.2 1 9.4 0.0 3.7 3 0 0 3 3 3 3 BNR/Asp-box repeat Mo-co_dimer PF03404.11 KII65860.1 - 0.14 11.7 0.2 3 7.4 0.0 2.4 2 1 1 3 3 3 0 Mo-co oxidoreductase dimerisation domain Spc7_C2 PF15577.1 KII65860.1 - 0.15 11.6 0.0 0.34 10.5 0.0 1.5 1 0 0 1 1 1 0 Spc7_C2 RVT_1 PF00078.22 KII65862.1 - 6.8e-08 32.1 0.0 1.2e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BNR PF02012.15 KII65863.1 - 0.019 14.6 0.0 0.44 10.5 0.0 2.4 2 0 0 2 2 2 0 BNR/Asp-box repeat AT_hook PF02178.14 KII65864.1 - 0.071 12.8 4.0 0.071 12.8 1.0 2.2 2 0 0 2 2 2 0 AT hook motif RNA_pol_L_2 PF13656.1 KII65869.1 - 1.4e-19 69.2 0.0 1.8e-19 68.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 KII65869.1 - 4.1e-06 25.8 0.0 7.9e-06 24.9 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DDE_Tnp_IS1595 PF12762.2 KII65870.1 - 6.4e-07 29.3 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF3648 PF12364.3 KII65872.1 - 0.15 12.0 2.1 2.6 8.0 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3648) Pkinase PF00069.20 KII65873.1 - 5.1e-18 65.1 0.1 5.6e-18 65.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII65873.1 - 4.9e-09 35.6 0.1 6e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SBDS_C PF09377.5 KII65873.1 - 0.075 12.7 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 SBDS protein C-terminal domain Augurin PF15187.1 KII65874.1 - 0.1 12.4 0.9 0.26 11.1 0.1 1.9 1 1 1 2 2 2 0 Oesophageal cancer-related gene 4 Ca_hom_mod PF14798.1 KII65875.1 - 8.9e-06 24.8 3.2 0.0011 18.0 1.0 2.4 1 1 1 2 2 2 2 Calcium homeostasis modulator DUF843 PF05814.6 KII65875.1 - 1.2 9.0 4.1 2 8.2 0.3 2.5 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) DUF3792 PF12670.2 KII65875.1 - 2 8.3 9.3 7.9 6.3 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) Ca_hom_mod PF14798.1 KII65876.1 - 0.0027 16.7 3.6 0.027 13.4 0.7 2.1 1 1 1 2 2 2 2 Calcium homeostasis modulator Ni_hydr_CYTB PF01292.15 KII65876.1 - 0.021 14.2 1.3 0.029 13.7 0.9 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 AceK PF06315.6 KII65876.1 - 0.075 11.2 0.1 0.1 10.8 0.0 1.2 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) VIT1 PF01988.14 KII65876.1 - 0.94 8.9 7.2 0.074 12.5 1.4 1.7 2 0 0 2 2 2 0 VIT family DUF843 PF05814.6 KII65876.1 - 3.4 7.5 9.9 1.7 8.5 0.7 2.7 3 0 0 3 3 3 0 Baculovirus protein of unknown function (DUF843) XPG_I PF00867.13 KII65877.1 - 1.6e-25 89.0 0.1 4.5e-25 87.5 0.0 1.9 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 KII65877.1 - 5.1e-21 74.8 0.1 1.6e-20 73.1 0.1 2.0 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.15 KII65877.1 - 0.28 11.4 1.8 2.8 8.2 0.0 3.0 3 0 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold DUF4352 PF11611.3 KII65878.1 - 0.03 14.4 0.3 0.19 11.8 0.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4352) DUF3949 PF13133.1 KII65878.1 - 0.09 13.0 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3949) BssC_TutF PF08201.6 KII65879.1 - 6 6.4 29.1 84 2.7 0.1 9.0 10 0 0 10 10 10 0 BssC/TutF protein CagY_M PF07337.6 KII65880.1 - 0.15 11.5 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 DC-EC Repeat DUF2042 PF09743.4 KII65883.1 - 2.2e-35 122.2 2.2 2.8e-35 121.9 1.5 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2042) Lipoxygenase PF00305.14 KII65885.1 - 3.5e-31 107.9 0.1 4.1e-31 107.7 0.1 1.0 1 0 0 1 1 1 1 Lipoxygenase PLAT PF01477.18 KII65886.1 - 8.7e-07 29.3 0.3 2.2e-06 28.0 0.2 1.6 1 1 0 1 1 1 1 PLAT/LH2 domain Lipoxygenase PF00305.14 KII65886.1 - 1.7e-05 23.0 0.0 2.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Lipoxygenase SAM_decarbox PF01536.11 KII65887.1 - 5.5e-70 235.6 0.1 6e-70 235.5 0.1 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Transglut_C PF00927.17 KII65889.1 - 0.0045 17.0 0.7 0.57 10.2 0.1 2.5 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain DUF11 PF01345.13 KII65889.1 - 0.087 12.8 0.0 0.55 10.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF11 Transglut_N PF00868.15 KII65890.1 - 6.2e-05 23.0 0.0 8.6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase family SAM_decarbox PF01536.11 KII65891.1 - 1.1e-68 231.3 0.0 1.2e-68 231.2 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase tRNA-synt_2d PF01409.15 KII65891.1 - 0.073 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Usp PF00582.21 KII65892.1 - 0.00022 21.4 0.0 0.0021 18.2 0.0 2.0 1 1 0 1 1 1 1 Universal stress protein family YcfA PF07927.7 KII65892.1 - 0.098 12.5 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 YcfA-like protein WD40 PF00400.27 KII65893.1 - 5.5e-33 111.6 14.7 1.4e-06 27.9 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KII65893.1 - 0.047 12.4 4.8 0.24 10.0 0.3 3.1 1 1 0 2 2 2 0 Nup133 N terminal like KNOX2 PF03791.8 KII65895.1 - 0.0079 15.4 1.6 0.022 14.0 0.3 2.4 2 0 0 2 2 2 1 KNOX2 domain CEP44 PF15007.1 KII65895.1 - 0.036 13.7 1.4 0.055 13.1 1.0 1.4 1 1 0 1 1 1 0 Centrosomal spindle body, CEP44 HSCB_C PF07743.8 KII65895.1 - 0.18 12.2 1.6 0.51 10.8 0.2 2.3 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain DUF1706 PF08020.6 KII65895.1 - 1.2 8.6 5.6 3.4 7.1 1.4 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1706) CarboxypepD_reg PF13620.1 KII65896.1 - 2.7e-14 52.9 0.0 4.4e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF4480 PF13715.1 KII65896.1 - 6.9e-09 35.6 0.0 1.3e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4480) CAP_GLY PF01302.20 KII65896.1 - 1.5e-08 34.1 0.0 2.2e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain RCC_reductase PF06405.6 KII65896.1 - 0.069 12.0 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) PEGA PF08308.6 KII65896.1 - 0.097 12.4 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 PEGA domain Peptidase_M14 PF00246.19 KII65897.1 - 3.5e-29 102.2 0.2 4.4e-29 101.9 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF2817 PF10994.3 KII65897.1 - 0.029 13.4 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Peptidase_M14 PF00246.19 KII65898.1 - 2e-26 93.2 0.0 3e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF3439 PF11921.3 KII65898.1 - 0.059 13.1 0.6 0.09 12.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Daxx PF03344.10 KII65898.1 - 0.065 11.7 0.9 0.081 11.4 0.6 1.1 1 0 0 1 1 1 0 Daxx Family zf-C2H2 PF00096.21 KII65900.1 - 9.3e-15 53.9 18.9 3.9e-05 23.7 2.1 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KII65900.1 - 4.2e-12 45.7 15.1 9.5e-07 28.8 0.3 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-met PF12874.2 KII65900.1 - 1.1e-09 38.1 9.8 0.0095 16.1 0.2 3.7 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 KII65900.1 - 3.9e-09 36.1 15.8 0.0017 18.5 1.2 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII65900.1 - 3.4e-07 30.2 5.6 0.0012 18.9 0.1 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 KII65900.1 - 0.0058 16.7 13.5 0.088 13.0 0.4 3.7 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-Di19 PF05605.7 KII65900.1 - 0.014 15.5 1.1 0.014 15.5 0.8 2.2 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-met2 PF12907.2 KII65900.1 - 0.076 12.9 3.3 3.7 7.5 0.0 3.3 3 0 0 3 3 3 0 Zinc-binding zf-BED PF02892.10 KII65900.1 - 0.25 11.1 19.4 3 7.6 2.8 3.5 2 1 1 3 3 3 0 BED zinc finger zf-C2H2_6 PF13912.1 KII65900.1 - 0.5 10.3 0.1 0.5 10.3 0.0 3.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 KII65900.1 - 0.53 10.4 9.2 2.9 8.0 0.3 3.2 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) C1_2 PF03107.11 KII65900.1 - 2.2 8.4 7.1 17 5.6 0.1 3.2 3 0 0 3 3 3 0 C1 domain Tnp_zf-ribbon_2 PF13842.1 KII65900.1 - 3.3 8.2 8.5 0.13 12.6 1.3 2.1 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon DDE_Tnp_IS1595 PF12762.2 KII65901.1 - 0.0014 18.5 0.0 0.003 17.4 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain Pkinase PF00069.20 KII65902.1 - 1.4e-46 158.8 0.0 9.3e-46 156.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII65902.1 - 5.8e-27 94.3 0.0 5e-25 88.0 0.0 2.8 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1436 PF07262.6 KII65902.1 - 0.048 13.1 0.0 0.098 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) Pkinase PF00069.20 KII65903.1 - 3.5e-18 65.6 0.0 3.9e-18 65.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII65903.1 - 4.3e-07 29.2 0.0 5e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF953 PF06110.6 KII65905.1 - 2e-18 65.9 0.0 2.3e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_7 PF13899.1 KII65905.1 - 0.0033 17.3 0.0 0.006 16.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KII65905.1 - 0.049 13.8 0.0 0.071 13.3 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain DUF836 PF05768.9 KII65907.1 - 0.14 12.4 0.2 0.39 11.0 0.1 1.8 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) AMP-binding PF00501.23 KII65908.1 - 1e-22 80.1 0.0 1.4e-22 79.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Post_transc_reg PF13797.1 KII65908.1 - 0.079 12.5 0.0 0.44 10.1 0.0 2.1 2 0 0 2 2 2 0 Post-transcriptional regulator DUF2135 PF09906.4 KII65908.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2135) AMP-binding PF00501.23 KII65909.1 - 2.1e-38 131.8 0.0 2.9e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme NUP PF06516.6 KII65910.1 - 0.11 11.2 0.1 0.13 11.0 0.1 1.0 1 0 0 1 1 1 0 Purine nucleoside permease (NUP) Met_10 PF02475.11 KII65917.1 - 1.1e-45 155.6 0.3 1.7e-45 155.1 0.2 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_18 PF12847.2 KII65917.1 - 2.1e-06 28.2 0.0 4.9e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TRM PF02005.11 KII65917.1 - 1.4e-05 24.2 0.1 3.7e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase MTS PF05175.9 KII65917.1 - 0.00026 20.3 0.0 0.00044 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FmrO PF07091.6 KII65917.1 - 0.00036 19.5 0.0 0.00056 18.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_15 PF09445.5 KII65917.1 - 0.0013 18.3 0.1 0.0027 17.2 0.1 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.8 KII65917.1 - 0.0022 17.1 0.0 0.0037 16.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.1 KII65917.1 - 0.008 15.7 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KII65917.1 - 0.013 15.5 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 KII65917.1 - 0.11 12.9 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain AAA PF00004.24 KII65918.1 - 3.3e-36 124.3 0.0 7.7e-36 123.2 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 KII65918.1 - 2.3e-06 27.6 0.0 4.7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KII65918.1 - 3.1e-05 24.0 0.0 0.00011 22.1 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 KII65918.1 - 3.3e-05 22.9 0.0 7.5e-05 21.7 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 KII65918.1 - 6.9e-05 23.0 0.2 0.0022 18.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KII65918.1 - 6.9e-05 22.5 0.1 0.00026 20.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KII65918.1 - 0.00035 21.3 0.0 0.0014 19.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KII65918.1 - 0.00046 19.3 0.1 0.018 14.1 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin RuvB_N PF05496.7 KII65918.1 - 0.00062 18.8 0.0 0.0013 17.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 KII65918.1 - 0.00071 18.7 0.1 0.0014 17.8 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KII65918.1 - 0.00081 19.0 0.1 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 KII65918.1 - 0.0011 18.4 0.0 0.0027 17.1 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.8 KII65918.1 - 0.0014 17.4 0.0 0.0028 16.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_28 PF13521.1 KII65918.1 - 0.0017 18.3 0.0 0.0033 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 KII65918.1 - 0.0025 17.9 0.0 0.0065 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.1 KII65918.1 - 0.0026 17.6 0.2 0.0093 15.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KII65918.1 - 0.0038 16.6 1.1 0.025 14.0 0.8 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII65918.1 - 0.004 17.4 0.0 0.015 15.6 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.1 KII65918.1 - 0.006 16.1 0.7 0.014 14.9 0.1 1.8 2 0 0 2 2 2 1 AAA domain DUF3666 PF12408.3 KII65918.1 - 0.011 14.8 0.5 0.048 12.7 0.0 2.4 3 0 0 3 3 2 0 Ribose-5-phosphate isomerase NTPase_1 PF03266.10 KII65918.1 - 0.011 15.4 0.1 0.045 13.4 0.0 2.1 3 0 0 3 3 2 0 NTPase AAA_14 PF13173.1 KII65918.1 - 0.014 15.2 0.0 0.038 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF1958 PF09211.5 KII65918.1 - 0.025 14.6 0.1 0.1 12.7 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1958) NACHT PF05729.7 KII65918.1 - 0.026 14.1 0.1 0.096 12.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.21 KII65918.1 - 0.029 13.8 0.1 0.11 11.9 0.0 2.0 2 1 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 KII65918.1 - 0.03 13.2 0.0 0.061 12.1 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2392 PF10288.4 KII65918.1 - 0.035 14.4 0.1 0.11 12.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2392) PhoH PF02562.11 KII65918.1 - 0.053 12.7 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein T2SE PF00437.15 KII65918.1 - 0.053 12.4 0.0 0.11 11.3 0.0 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 KII65918.1 - 0.061 12.8 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 KII65918.1 - 0.079 12.5 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_3 PF07726.6 KII65918.1 - 0.079 12.5 0.0 0.29 10.7 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 KII65918.1 - 0.087 11.6 0.0 0.21 10.4 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain SKI PF01202.17 KII65918.1 - 0.17 11.7 0.6 3.6 7.4 0.0 2.8 3 1 0 3 3 3 0 Shikimate kinase Ras PF00071.17 KII65919.1 - 2.5e-34 118.0 0.1 2.9e-34 117.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII65919.1 - 2.5e-16 60.2 0.2 4.1e-16 59.5 0.0 1.4 2 0 0 2 2 1 1 Miro-like protein CbiA PF01656.18 KII65919.1 - 8.5e-07 28.5 3.1 0.00054 19.4 0.0 2.1 1 1 1 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain Arf PF00025.16 KII65919.1 - 1.2e-06 27.8 0.0 1.4e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KII65919.1 - 3e-06 27.1 0.0 5.8e-06 26.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 KII65919.1 - 1.8e-05 23.9 0.0 4e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.22 KII65919.1 - 5.4e-05 22.7 0.9 0.00022 20.7 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain IstB_IS21 PF01695.12 KII65919.1 - 0.009 15.4 0.5 0.022 14.1 0.2 1.7 1 1 1 2 2 2 1 IstB-like ATP binding protein DUF258 PF03193.11 KII65919.1 - 0.0098 15.0 0.4 0.076 12.1 0.1 2.5 1 1 1 2 2 2 1 Protein of unknown function, DUF258 NB-ARC PF00931.17 KII65919.1 - 0.01 14.6 0.3 0.025 13.4 0.1 1.8 2 1 0 2 2 2 0 NB-ARC domain AAA_31 PF13614.1 KII65919.1 - 0.015 15.2 0.2 0.45 10.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 KII65919.1 - 0.021 14.2 0.4 0.059 12.8 0.3 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 KII65919.1 - 0.033 13.7 2.4 0.44 10.0 1.5 2.3 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.13 KII65919.1 - 0.07 12.4 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B YTH PF04146.10 KII65919.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 YT521-B-like domain ArsA_ATPase PF02374.10 KII65919.1 - 0.22 10.5 5.8 0.063 12.3 0.8 2.3 2 2 1 3 3 3 0 Anion-transporting ATPase SRP54 PF00448.17 KII65919.1 - 0.3 10.4 1.2 14 5.0 0.0 2.2 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain WW PF00397.21 KII65922.1 - 1.1e-08 34.7 0.5 2.3e-08 33.7 0.3 1.5 1 0 0 1 1 1 1 WW domain GDA1_CD39 PF01150.12 KII65923.1 - 3.5e-58 197.1 0.0 4.4e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family BLOC1_2 PF10046.4 KII65926.1 - 0.03 14.4 0.3 0.082 13.0 0.2 1.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF972 PF06156.8 KII65926.1 - 0.088 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Herpes_UL36 PF03586.8 KII65926.1 - 0.13 11.3 0.1 0.3 10.1 0.0 1.6 2 0 0 2 2 2 0 Herpesvirus UL36 tegument protein rve PF00665.21 KII65927.1 - 2e-18 66.6 0.0 1.4e-17 63.8 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain RVP_2 PF08284.6 KII65927.1 - 7.4e-07 29.1 0.1 1.5e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 KII65927.1 - 0.007 16.2 0.1 0.028 14.3 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII65927.1 - 0.04 13.7 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease SUR7 PF06687.7 KII65928.1 - 0.18 11.3 2.8 3.9 6.9 0.2 2.4 2 0 0 2 2 2 0 SUR7/PalI family Daxx PF03344.10 KII65929.1 - 0.14 10.6 31.6 0.19 10.1 21.9 1.2 1 0 0 1 1 1 0 Daxx Family SNAP PF14938.1 KII65933.1 - 1.8e-10 40.4 4.0 2.3e-10 40.0 2.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Patched PF02460.13 KII65935.1 - 4.8e-12 44.6 5.8 5.2e-12 44.5 4.0 1.0 1 0 0 1 1 1 1 Patched family MMPL PF03176.10 KII65935.1 - 0.09 11.4 0.2 0.1 11.3 0.2 1.1 1 0 0 1 1 1 0 MMPL family SecD_SecF PF02355.11 KII65935.1 - 0.25 10.5 4.3 0.37 9.9 3.0 1.3 1 1 0 1 1 1 0 Protein export membrane protein Sensor_TM1 PF13755.1 KII65935.1 - 0.58 9.7 3.0 1.2 8.6 0.9 2.3 1 1 1 2 2 2 0 Sensor N-terminal transmembrane domain DUF1673 PF07895.6 KII65935.1 - 0.59 9.6 6.5 0.72 9.3 4.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) HTH_29 PF13551.1 KII65939.1 - 0.095 12.8 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix DUF262 PF03235.9 KII65940.1 - 0.076 12.9 0.2 0.076 12.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF262 Gal-3-0_sulfotr PF06990.6 KII65942.1 - 2e-10 39.9 1.8 2.8e-09 36.1 1.3 1.9 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Tagatose_6_P_K PF08013.6 KII65944.1 - 0.3 9.4 1.7 0.3 9.4 1.2 1.0 1 0 0 1 1 1 0 Tagatose 6 phosphate kinase E1_DerP2_DerF2 PF02221.10 KII65945.1 - 2e-10 41.0 0.1 2.1e-10 40.9 0.1 1.0 1 0 0 1 1 1 1 ML domain PH_9 PF15410.1 KII65946.1 - 0.01 15.9 0.7 0.13 12.4 0.2 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain Ogr_Delta PF04606.7 KII65951.1 - 0.091 12.4 0.2 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger PurA PF04845.8 KII65952.1 - 6.5e-12 45.0 0.2 2.2e-08 33.4 0.0 2.5 2 1 0 2 2 2 2 PurA ssDNA and RNA-binding protein NUC153 PF08159.7 KII65954.1 - 2.1e-09 36.7 2.0 2.6e-09 36.4 0.1 2.2 2 0 0 2 2 2 1 NUC153 domain RRM_1 PF00076.17 KII65954.1 - 0.0061 16.1 0.1 0.017 14.7 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TBCA PF02970.11 KII65955.1 - 9.6e-10 38.4 4.1 1.2e-09 38.1 2.9 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A BAR PF03114.13 KII65955.1 - 3e-05 23.6 3.1 3.2e-05 23.5 2.1 1.0 1 0 0 1 1 1 1 BAR domain GLYCAM-1 PF05242.6 KII65955.1 - 0.0013 18.6 0.4 0.0015 18.4 0.3 1.1 1 0 0 1 1 1 1 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) YkyA PF10368.4 KII65955.1 - 0.0067 15.7 2.0 0.0076 15.6 1.4 1.1 1 0 0 1 1 1 1 Putative cell-wall binding lipoprotein HOOK PF05622.7 KII65955.1 - 0.0084 13.9 3.6 0.0086 13.9 2.5 1.1 1 0 0 1 1 1 1 HOOK protein DUF948 PF06103.6 KII65955.1 - 0.0088 15.8 3.6 0.39 10.6 0.7 2.1 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.7 KII65955.1 - 0.01 15.6 2.3 0.012 15.3 1.6 1.1 1 0 0 1 1 1 0 Laminin Domain II DUF3552 PF12072.3 KII65955.1 - 0.011 14.9 3.3 0.013 14.7 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Tropomyosin_1 PF12718.2 KII65955.1 - 0.022 14.6 3.3 0.025 14.4 2.3 1.1 1 0 0 1 1 1 0 Tropomyosin like Baculo_p24 PF05073.7 KII65955.1 - 0.025 14.1 2.5 0.03 13.8 1.7 1.2 1 0 0 1 1 1 0 Baculovirus P24 capsid protein NEP PF10167.4 KII65955.1 - 0.041 13.5 0.9 0.051 13.2 0.7 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein Reo_sigmaC PF04582.7 KII65955.1 - 0.044 12.9 2.0 0.046 12.9 1.4 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF2365 PF10157.4 KII65955.1 - 0.052 13.4 2.4 0.77 9.6 0.3 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2365) LXG PF04740.7 KII65955.1 - 0.056 13.2 4.4 0.14 11.8 2.8 1.7 1 1 0 1 1 1 0 LXG domain of WXG superfamily DUF1395 PF07160.7 KII65955.1 - 0.067 12.6 2.4 0.087 12.3 1.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1395) Fmp27_WPPW PF10359.4 KII65955.1 - 0.068 11.5 3.7 0.073 11.4 2.6 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain IncA PF04156.9 KII65955.1 - 0.088 12.3 4.3 0.097 12.2 3.0 1.1 1 0 0 1 1 1 0 IncA protein Baculo_PEP_C PF04513.7 KII65955.1 - 0.091 12.5 1.8 0.12 12.2 1.3 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PXA PF02194.10 KII65955.1 - 0.15 11.6 2.6 0.16 11.5 1.8 1.1 1 0 0 1 1 1 0 PXA domain HisKA_3 PF07730.8 KII65955.1 - 0.16 12.3 0.7 16 5.9 0.0 2.2 1 1 1 2 2 2 0 Histidine kinase DUF2779 PF11074.3 KII65955.1 - 0.16 12.0 0.6 0.29 11.1 0.4 1.6 1 1 0 1 1 1 0 Domain of unknown function(DUF2779) NPV_P10 PF05531.7 KII65955.1 - 0.2 11.9 1.5 0.27 11.5 1.0 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein SMC_N PF02463.14 KII65959.1 - 8.8e-38 129.7 0.2 9.6e-38 129.6 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KII65959.1 - 1.8e-06 28.1 0.6 2.5e-06 27.7 0.4 1.2 1 0 0 1 1 1 1 AAA domain Lge1 PF11488.3 KII65959.1 - 0.032 14.4 1.1 0.056 13.6 0.8 1.4 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 SbcCD_C PF13558.1 KII65959.1 - 0.039 13.8 0.1 0.083 12.8 0.0 1.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.1 KII65959.1 - 0.056 12.4 5.8 0.095 11.7 4.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain SMC_hinge PF06470.8 KII65960.1 - 1.9e-26 92.3 0.0 6.8e-26 90.5 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain IncA PF04156.9 KII65960.1 - 8.5e-08 32.0 69.4 4.5e-05 23.1 16.3 4.3 4 1 1 5 5 5 3 IncA protein Tropomyosin PF00261.15 KII65960.1 - 0.0036 16.4 25.1 0.0036 16.4 17.4 4.7 3 1 0 4 4 4 1 Tropomyosin ATG16 PF08614.6 KII65960.1 - 0.0044 16.8 32.1 0.0044 16.8 22.3 3.5 2 1 0 3 3 3 1 Autophagy protein 16 (ATG16) AAA_13 PF13166.1 KII65960.1 - 0.022 13.2 65.5 0.069 11.6 25.7 3.4 2 1 1 3 3 3 0 AAA domain Ribosomal_S4 PF00163.14 KII65960.1 - 0.034 14.5 1.6 0.034 14.5 1.1 2.9 3 0 0 3 3 3 0 Ribosomal protein S4/S9 N-terminal domain AAA_27 PF13514.1 KII65960.1 - 0.095 10.3 48.8 0.036 11.7 18.5 3.1 2 1 1 3 3 3 0 AAA domain Laminin_II PF06009.7 KII65960.1 - 0.17 11.6 53.0 0.11 12.2 8.6 5.5 3 1 2 6 6 6 0 Laminin Domain II CENP-Q PF13094.1 KII65960.1 - 0.34 10.9 68.7 2.7 8.0 7.1 4.7 2 1 2 4 4 4 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF869 PF05911.6 KII65960.1 - 0.55 8.4 60.5 0.33 9.1 31.9 2.7 2 1 0 2 2 2 0 Plant protein of unknown function (DUF869) Reo_sigmaC PF04582.7 KII65960.1 - 0.8 8.8 29.4 0.14 11.3 5.0 4.1 2 2 1 4 4 4 0 Reovirus sigma C capsid protein APG6 PF04111.7 KII65960.1 - 1.6 7.7 70.2 0.084 11.9 17.2 3.7 3 1 0 4 4 4 0 Autophagy protein Apg6 SMC_N PF02463.14 KII65961.1 - 2.4e-36 125.0 6.3 9.5e-36 123.0 4.3 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KII65961.1 - 3e-10 40.7 26.0 9.8e-09 35.8 18.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KII65961.1 - 2.8e-07 30.7 12.3 2.7e-06 27.5 8.6 2.3 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 KII65961.1 - 8.2e-07 28.4 22.4 3.4e-06 26.3 15.5 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 KII65961.1 - 2.7e-05 23.6 0.0 4.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain CCDC155 PF14662.1 KII65961.1 - 0.038 13.5 15.7 0.31 10.6 6.9 2.3 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Cortex-I_coil PF09304.5 KII65961.1 - 0.11 12.5 14.1 0.35 10.9 9.4 2.0 1 1 0 1 1 1 0 Cortexillin I, coiled coil ABC_tran PF00005.22 KII65961.1 - 0.26 11.5 4.4 1.2 9.4 3.0 2.3 1 1 0 1 1 1 0 ABC transporter SMC_N PF02463.14 KII65962.1 - 2e-36 125.3 6.0 7.7e-36 123.3 4.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KII65962.1 - 2.6e-10 40.9 25.4 7.8e-09 36.1 17.6 2.0 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KII65962.1 - 5.8e-07 29.7 12.2 5.7e-06 26.5 8.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 KII65962.1 - 1.2e-06 27.8 22.8 5.1e-06 25.7 15.8 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 KII65962.1 - 2.6e-05 23.6 0.0 4.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain CCDC155 PF14662.1 KII65962.1 - 0.041 13.4 15.7 0.33 10.5 6.9 2.2 1 1 0 2 2 2 0 Coiled-coil region of CCDC155 DUF1040 PF06288.8 KII65962.1 - 0.067 13.4 0.3 0.067 13.4 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1040) ABC_tran PF00005.22 KII65962.1 - 0.075 13.3 2.6 0.096 12.9 0.0 2.2 2 1 0 2 2 2 0 ABC transporter Cortex-I_coil PF09304.5 KII65962.1 - 0.11 12.5 14.1 0.35 10.9 9.4 2.0 1 1 0 1 1 1 0 Cortexillin I, coiled coil Lipl32 PF12103.3 KII65962.1 - 0.19 11.1 4.0 0.38 10.2 1.2 2.2 2 1 0 2 2 2 0 Surface lipoprotein of Spirochaetales order PFK PF00365.15 KII65964.1 - 9.2e-23 80.5 0.1 5e-14 51.9 0.0 2.1 2 0 0 2 2 2 2 Phosphofructokinase Transposase_28 PF04195.7 KII65966.1 - 0.065 12.5 1.0 0.11 11.7 0.5 1.5 1 1 1 2 2 2 0 Putative gypsy type transposon rve PF00665.21 KII65968.1 - 1.1e-28 99.7 0.0 3.9e-28 97.9 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.5 KII65968.1 - 0.00017 20.8 0.0 0.00017 20.8 0.0 2.1 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII65968.1 - 0.0097 15.4 0.0 0.031 13.7 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII65968.1 - 0.041 13.8 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.22 KII65969.1 - 3.1e-24 85.5 0.0 5.4e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII65969.1 - 1.3e-05 25.0 0.1 3.2e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII65969.1 - 2.9e-05 23.7 11.4 0.01 15.6 1.9 2.5 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII65969.1 - 0.0014 19.0 0.1 0.0029 18.0 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII65969.1 - 0.01 15.6 0.0 0.052 13.3 0.0 2.2 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII65969.1 - 0.012 15.2 5.7 0.19 11.4 0.4 2.8 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.9 KII65969.1 - 0.036 13.9 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_6 PF15288.1 KII65969.1 - 0.12 12.0 12.3 0.85 9.3 0.7 2.5 2 0 0 2 2 2 0 Zinc knuckle DDE_Tnp_IS1595 PF12762.2 KII65970.1 - 8e-10 38.7 0.0 9.4e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain WD40 PF00400.27 KII65972.1 - 2.7e-29 99.9 3.4 1.2e-10 40.8 0.2 3.5 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.3 KII65972.1 - 0.023 12.8 0.3 1.4 6.9 0.0 2.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Trypan_PARP PF05887.6 KII65973.1 - 0.44 10.3 2.3 0.51 10.1 1.6 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SynMuv_product PF06047.6 KII65974.1 - 6.8e-06 25.7 0.7 1.8e-05 24.3 0.2 1.8 2 0 0 2 2 2 1 Ras-induced vulval development antagonist Ycf1 PF05758.7 KII65974.1 - 0.00085 17.1 2.2 0.00093 17.0 1.5 1.0 1 0 0 1 1 1 1 Ycf1 FLYWCH PF04500.11 KII65975.1 - 3.4e-09 36.4 1.9 5.2e-09 35.8 1.3 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain GSHPx PF00255.14 KII65976.1 - 1.6e-25 88.5 0.1 2.9e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase Na_H_antiport_1 PF06965.7 KII65977.1 - 0.038 12.7 3.1 0.032 13.0 1.5 1.4 1 1 0 1 1 1 0 Na+/H+ antiporter 1 DUF1282 PF06930.7 KII65977.1 - 0.2 11.2 6.8 0.27 10.8 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) HVSL PF09749.4 KII65978.1 - 1.7e-16 59.9 0.8 3.1e-13 49.3 0.1 2.3 1 1 1 2 2 2 2 Uncharacterised conserved protein tRNA_int_endo PF01974.12 KII65979.1 - 4.4e-15 55.2 0.0 8.3e-15 54.3 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain DUF2812 PF11193.3 KII65981.1 - 0.061 13.4 0.1 0.093 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2812) ORF6C PF10552.4 KII65982.1 - 1.8 8.3 11.6 12 5.7 0.3 3.2 1 1 2 3 3 3 0 ORF6C domain Cep57_CLD PF14073.1 KII65982.1 - 2 8.2 6.3 3 7.6 4.4 1.4 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 SRR PF07709.6 KII65982.1 - 4.1 8.0 6.2 2e+02 2.9 0.0 4.5 5 0 0 5 5 5 0 Seven Residue Repeat EF-hand_1 PF00036.27 KII65985.1 - 1.4e-23 80.3 6.8 7.3e-06 24.9 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KII65985.1 - 5.4e-23 80.9 4.7 3.9e-13 49.3 0.6 2.6 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KII65985.1 - 7.3e-20 69.0 3.4 0.00024 20.7 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KII65985.1 - 1.7e-17 61.8 7.4 7.7e-05 21.8 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KII65985.1 - 5.6e-13 48.2 8.3 2.4e-05 23.8 0.3 4.6 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KII65985.1 - 2.1e-07 30.9 0.0 0.019 14.9 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KII65985.1 - 1.6e-05 24.5 1.0 0.027 14.1 0.2 2.9 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KII65985.1 - 0.0002 21.2 0.0 0.11 12.3 0.0 3.2 3 1 0 3 3 3 1 EF-hand domain EF-hand_2 PF09068.6 KII65985.1 - 0.0044 17.0 0.1 3.1 7.8 0.0 3.1 2 1 1 3 3 3 1 EF hand Toprim_2 PF13155.1 KII65985.1 - 0.0045 17.2 0.3 0.14 12.4 0.1 2.2 1 1 1 2 2 2 1 Toprim-like WD40 PF00400.27 KII65987.1 - 1.3e-54 180.1 18.7 3.7e-13 48.8 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KII65987.1 - 0.00011 20.5 5.3 0.036 12.2 0.2 3.7 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KII65987.1 - 0.024 13.4 3.7 0.57 8.8 1.1 2.7 1 1 2 3 3 3 0 Nup133 N terminal like Chs3p PF12271.3 KII65989.1 - 0.055 12.4 0.1 0.086 11.7 0.1 1.3 1 0 0 1 1 1 0 Chitin synthase III catalytic subunit Ribosomal_L35Ae PF01247.13 KII65990.1 - 5.3e-32 109.4 0.9 6.2e-32 109.2 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 KII65990.1 - 5.2e-06 26.2 0.0 0.011 15.6 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Telomerase_RBD PF12009.3 KII65991.1 - 0.12 12.2 1.6 0.16 11.9 1.1 1.2 1 0 0 1 1 1 0 Telomerase ribonucleoprotein complex - RNA binding domain BPL_N PF09825.4 KII65993.1 - 0.011 14.5 0.1 0.014 14.2 0.0 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Catalase-rel PF06628.7 KII65993.1 - 0.12 12.2 0.2 24 4.8 0.0 2.8 3 0 0 3 3 3 0 Catalase-related immune-responsive SRCR_2 PF15494.1 KII65993.1 - 0.13 12.5 0.1 0.26 11.5 0.0 1.5 1 1 1 2 2 2 0 Scavenger receptor cysteine-rich domain DUF2096 PF09869.4 KII65994.1 - 0.09 12.6 0.0 0.25 11.2 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) rve PF00665.21 KII65995.1 - 2.2e-16 60.0 0.1 2.9e-16 59.6 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII65995.1 - 0.0023 17.2 0.2 0.004 16.5 0.1 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DDE_3 PF13358.1 KII65996.1 - 6.7e-07 29.1 0.1 8e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Dimer_Tnp_hAT PF05699.9 KII65997.1 - 0.0068 15.9 0.2 0.0068 15.9 0.1 1.9 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Tetraspannin PF00335.15 KII66000.1 - 7.5e-12 44.9 14.7 9.9e-12 44.6 10.2 1.1 1 0 0 1 1 1 1 Tetraspanin family Claudin_2 PF13903.1 KII66000.1 - 0.89 9.2 11.8 2.9 7.5 6.7 2.2 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF962 PF06127.6 KII66000.1 - 1 9.3 5.6 0.3 10.9 0.7 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF962) DUF1422 PF07226.6 KII66000.1 - 6.1 6.6 10.9 1.4 8.6 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1422) Ribophorin_II PF05817.9 KII66000.1 - 9.5 4.2 6.7 13 3.7 4.7 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II IRF PF00605.12 KII66004.1 - 0.11 12.2 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Interferon regulatory factor transcription factor HTH_21 PF13276.1 KII66008.1 - 6.1e-07 29.3 1.1 9.5e-07 28.7 0.2 1.8 2 0 0 2 2 2 1 HTH-like domain dCMP_cyt_deam_1 PF00383.17 KII66009.1 - 1.3e-17 63.3 0.1 2.2e-17 62.5 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region OTT_1508_deam PF14441.1 KII66009.1 - 0.1 12.3 0.1 0.24 11.1 0.1 1.6 1 0 0 1 1 1 0 OTT_1508-like deaminase HTH_Tnp_1 PF01527.15 KII66010.1 - 2.3e-09 37.0 0.0 5.5e-09 35.8 0.0 1.6 2 0 0 2 2 2 1 Transposase HTH_29 PF13551.1 KII66010.1 - 0.065 13.3 0.1 0.1 12.7 0.0 1.3 1 1 0 1 1 1 0 Winged helix-turn helix Myticin-prepro PF10690.4 KII66010.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel RVT_3 PF13456.1 KII66010.1 - 0.11 12.2 0.1 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like Vps55 PF04133.9 KII66013.1 - 0.22 11.2 4.4 3.3 7.4 0.1 2.9 2 1 1 3 3 3 0 Vacuolar protein sorting 55 LysM PF01476.15 KII66015.1 - 3.8e-07 29.8 0.0 2.1e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 LysM domain G_glu_transpept PF01019.16 KII66016.1 - 3.1e-25 88.6 0.0 3.4e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.16 KII66017.1 - 4.3e-81 272.9 0.0 4.8e-81 272.7 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Curto_V2 PF07325.6 KII66019.1 - 0.11 12.1 0.0 0.34 10.5 0.0 1.8 2 0 0 2 2 2 0 Curtovirus V2 protein Ribosomal_L6e PF01159.14 KII66021.1 - 2.2e-32 111.5 0.6 2.2e-32 111.5 0.4 2.0 2 0 0 2 2 2 1 Ribosomal protein L6e DDE_3 PF13358.1 KII66022.1 - 1.9e-11 43.9 0.1 2.3e-11 43.6 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Prp31_C PF09785.4 KII66023.1 - 2.9e-37 127.8 0.6 4.2e-37 127.3 0.4 1.2 1 0 0 1 1 1 1 Prp31 C terminal domain Nop PF01798.13 KII66023.1 - 5.9e-24 84.0 0.0 1.2e-23 83.1 0.0 1.5 1 0 0 1 1 1 1 Putative snoRNA binding domain DUF2397 PF09660.5 KII66023.1 - 0.036 12.6 0.5 0.063 11.8 0.2 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2397) NOSIC PF08060.8 KII66024.1 - 4.9e-16 58.2 0.5 9e-16 57.4 0.4 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain MAP65_ASE1 PF03999.7 KII66024.1 - 0.09 11.3 0.0 0.11 11.0 0.0 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) 2Fe-2S_thioredx PF01257.14 KII66025.1 - 1.5e-58 196.4 0.0 2e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Phage_connect_1 PF05135.8 KII66025.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein DUF947 PF06102.7 KII66026.1 - 1.2e-25 90.3 31.2 1.3e-25 90.1 21.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF947) zf-SNAP50_C PF12251.3 KII66027.1 - 1.8e-37 128.6 8.7 3.9e-37 127.5 6.1 1.5 1 1 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal F-box PF00646.28 KII66027.1 - 0.56 9.9 2.7 0.73 9.5 0.3 2.3 3 0 0 3 3 3 0 F-box domain MULE PF10551.4 KII66030.1 - 2.6e-06 27.4 0.1 5.8e-06 26.3 0.0 1.6 1 1 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.12 KII66030.1 - 0.05 13.1 0.0 0.058 12.9 0.0 1.1 1 0 0 1 1 1 0 Transposase AviRa PF11599.3 KII66030.1 - 0.073 12.0 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Folate_rec PF03024.9 KII66031.1 - 2.8e-29 101.8 14.4 3e-29 101.7 9.9 1.0 1 0 0 1 1 1 1 Folate receptor family DUF3657 PF12394.3 KII66031.1 - 0.081 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3657) Zip PF02535.17 KII66032.1 - 1.8e-25 89.6 18.5 9.1e-23 80.7 4.4 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter Hydrolase_like PF13242.1 KII66033.1 - 1.4e-16 59.9 0.0 2.1e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 KII66033.1 - 1.1e-05 25.6 0.0 1.5e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KII66033.1 - 1.3e-05 25.7 0.0 1.4e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 KII66033.1 - 0.018 14.4 0.4 0.051 12.9 0.1 1.7 1 1 1 2 2 2 0 Mitochondrial PGP phosphatase BNR PF02012.15 KII66034.1 - 2.7e-05 23.3 2.2 0.23 11.4 0.0 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat Prp19 PF08606.6 KII66036.1 - 0.012 15.3 0.4 0.044 13.5 0.1 2.0 2 0 0 2 2 2 0 Prp19/Pso4-like Pollen_allerg_1 PF01357.16 KII66037.1 - 0.082 12.7 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Pollen allergen Rifin_STEVOR PF02009.11 KII66038.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Rifin/stevor family RCR PF12273.3 KII66038.1 - 0.17 12.4 2.2 0.38 11.3 1.6 1.6 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red RasGEF PF00617.14 KII66040.1 - 2.4e-39 135.0 6.8 3e-39 134.7 4.7 1.1 1 0 0 1 1 1 1 RasGEF domain DUF1944 PF09175.5 KII66040.1 - 0.052 13.1 0.2 0.087 12.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1944) ACOX PF01756.14 KII66040.1 - 0.075 12.4 2.2 0.33 10.2 0.3 2.0 1 1 1 2 2 2 0 Acyl-CoA oxidase DDE_3 PF13358.1 KII66041.1 - 6.3e-09 35.7 0.0 7.6e-07 28.9 0.0 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease PAX PF00292.13 KII66041.1 - 0.052 13.2 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 'Paired box' domain Ribosomal_S19e PF01090.14 KII66044.1 - 1.2e-44 151.1 0.0 1.4e-44 150.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_L16 PF00252.13 KII66046.1 - 3.7e-27 94.6 0.2 4.6e-27 94.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Arfaptin PF06456.8 KII66048.1 - 2.9e-16 59.4 6.5 2.9e-16 59.4 4.5 1.6 2 0 0 2 2 2 1 Arfaptin-like domain Lge1 PF11488.3 KII66048.1 - 0.45 10.7 8.3 15 5.8 0.1 3.8 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 MT-A70 PF05063.9 KII66049.1 - 6.5e-24 84.4 0.0 1e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 MT-A70 PHD PF00628.24 KII66050.1 - 6e-08 32.2 2.8 6e-08 32.2 1.9 3.6 3 1 0 3 3 3 3 PHD-finger PHD_2 PF13831.1 KII66050.1 - 1.1e-06 27.8 1.1 1.1e-06 27.8 0.8 4.5 5 1 0 5 5 5 1 PHD-finger C1_1 PF00130.17 KII66050.1 - 0.0031 17.2 30.6 0.006 16.2 1.4 4.2 3 1 1 4 4 4 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 KII66050.1 - 0.044 13.5 0.9 0.044 13.5 0.6 4.4 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.1 KII66050.1 - 0.05 12.9 0.4 0.05 12.9 0.3 3.3 4 0 0 4 4 4 0 PHD/FYVE-zinc-finger like domain PhnA_Zn_Ribbon PF08274.7 KII66050.1 - 1.5 8.6 15.3 0.76 9.6 0.1 4.5 4 1 0 4 4 4 0 PhnA Zinc-Ribbon DNA_RNApol_7kD PF03604.8 KII66050.1 - 7.8 6.0 19.2 1.5 8.3 0.1 4.7 5 0 0 5 5 5 0 DNA directed RNA polymerase, 7 kDa subunit Mito_carr PF00153.22 KII66051.1 - 9.5e-47 156.6 3.1 8e-19 67.1 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Vps52 PF04129.7 KII66052.1 - 0.037 12.5 0.1 0.043 12.3 0.1 1.1 1 0 0 1 1 1 0 Vps52 / Sac2 family zf-RING_5 PF14634.1 KII66052.1 - 0.15 11.8 1.5 0.26 11.0 1.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain DDE_3 PF13358.1 KII66053.1 - 4.7e-17 62.0 0.0 5.5e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RRM_1 PF00076.17 KII66054.1 - 3.4e-26 90.6 1.1 1.3e-11 43.9 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII66054.1 - 8.3e-19 67.3 0.0 1.8e-05 24.5 0.0 3.5 3 1 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII66054.1 - 1.5e-15 56.7 0.0 5.6e-06 26.1 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4342 PF14242.1 KII66055.1 - 1.9 8.3 11.5 0.45 10.3 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) Glycolytic PF00274.14 KII66057.1 - 1.2e-148 494.1 0.0 1.4e-148 494.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I DDE_3 PF13358.1 KII66058.1 - 8.2e-10 38.6 0.0 2e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_hydro_47 PF01532.15 KII66059.1 - 3.9e-87 292.8 1.0 4.8e-87 292.5 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.17 KII66059.1 - 2.8e-11 42.9 0.1 5.7e-11 42.0 0.1 1.5 1 0 0 1 1 1 1 PA domain Ribonuc_red_sm PF00268.16 KII66061.1 - 1.9e-55 187.8 0.5 2.4e-55 187.5 0.3 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain NMT PF01233.14 KII66061.1 - 0.00021 20.9 0.1 0.00042 19.9 0.1 1.5 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Ribonuc_red_sm PF00268.16 KII66062.1 - 1.2e-31 109.8 0.1 1.4e-31 109.5 0.1 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain ResB PF05140.9 KII66063.1 - 4.4 5.7 4.6 25 3.2 1.8 2.6 1 1 1 2 2 2 0 ResB-like family GspL_C PF12693.2 KII66068.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 GspL periplasmic domain Choline_kinase PF01633.15 KII66070.1 - 2.4e-48 164.5 2.4 2.4e-48 164.5 1.7 2.5 2 1 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 KII66070.1 - 4.8e-10 39.5 0.0 9.2e-10 38.6 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 KII66070.1 - 0.00075 18.7 0.3 0.0018 17.4 0.2 1.6 2 0 0 2 2 2 1 Ecdysteroid kinase Sulfolobus_pRN PF05584.6 KII66073.1 - 0.024 14.6 0.1 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein NAD_binding_7 PF13241.1 KII66073.1 - 0.12 12.6 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 Putative NAD(P)-binding DUF4476 PF14771.1 KII66075.1 - 0.0074 16.2 0.3 0.022 14.7 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4476) AAR2 PF05282.6 KII66076.1 - 1.8e-59 201.4 2.5 2.3e-59 201.1 1.7 1.1 1 0 0 1 1 1 1 AAR2 protein Methyltransf_31 PF13847.1 KII66076.1 - 0.042 13.4 0.6 0.087 12.4 0.2 1.7 2 0 0 2 2 2 0 Methyltransferase domain DUF4604 PF15377.1 KII66076.1 - 0.07 13.3 0.3 0.07 13.3 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Peptidase_C65 PF10275.4 KII66076.1 - 0.13 11.6 2.0 0.75 9.1 0.4 2.8 1 1 1 3 3 3 0 Peptidase C65 Otubain Fcf1 PF04900.7 KII66077.1 - 6.3e-38 128.9 0.5 1.1e-37 128.1 0.4 1.4 1 0 0 1 1 1 1 Fcf1 PrsW-protease PF13367.1 KII66079.1 - 0.034 13.3 0.1 0.055 12.6 0.0 1.3 1 0 0 1 1 1 0 Protease prsW family Glyco_hydro_42C PF08533.5 KII66079.1 - 0.061 12.8 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain BNR PF02012.15 KII66081.1 - 0.027 14.2 1.2 0.049 13.4 0.3 1.9 2 0 0 2 2 2 0 BNR/Asp-box repeat DUF4459 PF14673.1 KII66082.1 - 0.16 11.6 0.9 1.4 8.6 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4459) Ldl_recept_a PF00057.13 KII66083.1 - 4.2e-30 103.3 52.3 1.8e-13 50.1 7.4 3.3 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII66084.1 - 3.8e-10 39.4 30.8 5.5e-05 22.9 6.9 2.5 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII66084.1 - 0.0087 15.6 12.7 0.013 15.1 8.8 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like DUF2407_C PF13373.1 KII66084.1 - 0.11 12.4 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 DUF2407 C-terminal domain Glyco_transf_43 PF03360.11 KII66087.1 - 1.7e-26 93.0 0.2 1.9e-25 89.6 0.0 2.4 3 0 0 3 3 3 1 Glycosyltransferase family 43 zf-met PF12874.2 KII66088.1 - 4.2e-06 26.7 1.3 4.2e-06 26.7 0.9 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.4 KII66088.1 - 0.00091 18.8 1.6 0.0015 18.1 1.1 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Arf PF00025.16 KII66089.1 - 4.4e-26 91.1 0.0 5.3e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KII66089.1 - 1e-12 47.7 0.0 1.1e-12 47.5 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 KII66089.1 - 1.6e-12 47.0 0.0 1.8e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 KII66089.1 - 2.8e-09 37.4 0.0 4.5e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein G-alpha PF00503.15 KII66089.1 - 1.2e-06 27.4 0.2 0.00017 20.4 0.0 2.8 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.18 KII66089.1 - 1.3e-05 25.1 0.0 1.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 KII66089.1 - 0.00062 18.9 0.0 0.00067 18.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 KII66089.1 - 0.0046 17.1 0.0 0.0092 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KII66089.1 - 0.054 13.3 0.0 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 KII66089.1 - 0.066 12.7 0.0 2 7.8 0.0 2.4 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Arch_ATPase PF01637.13 KII66089.1 - 0.067 12.8 0.0 0.077 12.6 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase PduV-EutP PF10662.4 KII66089.1 - 0.11 11.9 0.1 5.8 6.4 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PepSY_TM_1 PF13172.1 KII66090.1 - 0.0093 15.6 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 PepSY-associated TM helix DUF912 PF06024.7 KII66090.1 - 0.034 14.1 0.5 0.047 13.7 0.3 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DDE_Tnp_IS1595 PF12762.2 KII66091.1 - 3.5e-10 39.9 0.0 1.1e-05 25.3 0.1 2.4 2 1 0 2 2 2 2 ISXO2-like transposase domain Syd PF07348.7 KII66092.1 - 0.053 12.8 2.0 1.7 7.9 0.2 2.2 1 1 1 2 2 2 0 Syd protein (SUKH-2) PRD_Mga PF08270.6 KII66093.1 - 0.0011 18.2 1.5 0.0016 17.7 0.3 1.8 2 0 0 2 2 2 1 M protein trans-acting positive regulator (MGA) PRD domain Rifin_STEVOR PF02009.11 KII66095.1 - 0.00044 20.0 0.5 0.00051 19.7 0.4 1.1 1 0 0 1 1 1 1 Rifin/stevor family TMEM154 PF15102.1 KII66095.1 - 0.0047 16.6 2.4 0.0056 16.4 1.7 1.2 1 0 0 1 1 1 1 TMEM154 protein family DUF912 PF06024.7 KII66095.1 - 0.037 14.0 0.9 0.052 13.6 0.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) NADH_dehy_S2_C PF06444.6 KII66095.1 - 0.2 11.9 4.5 0.4 11.0 3.1 1.5 1 0 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus DUF3139 PF11337.3 KII66095.1 - 1.5 9.1 6.7 2 8.7 3.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3139) DDE_3 PF13358.1 KII66096.1 - 2.8e-16 59.5 0.1 4.7e-16 58.8 0.0 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease UDPGT PF00201.13 KII66096.1 - 0.045 12.3 0.0 0.045 12.3 0.0 1.0 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase DUF3975 PF13126.1 KII66097.1 - 0.072 13.2 1.0 0.68 10.1 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3975) P21-Arc PF04062.9 KII66099.1 - 0.083 12.6 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 ARP2/3 complex ARPC3 (21 kDa) subunit Serpin PF00079.15 KII66100.1 - 6.6e-44 150.5 2.3 7.3e-44 150.3 1.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Tetraspannin PF00335.15 KII66101.1 - 0.028 13.6 0.4 0.032 13.5 0.3 1.1 1 0 0 1 1 1 0 Tetraspanin family DUF4448 PF14610.1 KII66101.1 - 0.032 13.7 0.5 0.13 11.6 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4448) Involucrin_N PF10583.4 KII66101.1 - 0.086 13.1 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Involucrin of squamous epithelia N-terminus DUF912 PF06024.7 KII66101.1 - 3 7.9 8.0 0.45 10.5 1.0 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PurA PF04845.8 KII66103.1 - 1.9e-09 36.9 2.6 0.0038 16.3 0.0 2.9 1 1 1 3 3 3 3 PurA ssDNA and RNA-binding protein PIF1 PF05970.9 KII66105.1 - 7e-42 143.6 0.1 9.7e-42 143.1 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Kelch_6 PF13964.1 KII66109.1 - 7.3e-27 92.4 18.9 4.5e-06 26.5 0.2 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII66109.1 - 3.4e-24 84.3 22.2 2.8e-07 30.1 0.4 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII66109.1 - 4.2e-17 61.7 10.1 0.00011 22.2 0.1 6.5 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII66109.1 - 5e-16 57.7 12.9 5.9e-05 22.6 0.1 6.2 6 1 0 6 6 6 3 Kelch motif Kelch_1 PF01344.20 KII66109.1 - 7e-12 44.6 34.9 8.5e-05 22.0 0.4 6.7 6 2 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 KII66109.1 - 6e-11 42.0 17.4 3.3e-06 26.9 0.0 6.0 6 0 0 6 6 6 3 Kelch motif zf-C2HC5 PF06221.8 KII66110.1 - 0.51 10.1 3.6 0.55 10.0 2.0 1.4 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Kelch_6 PF13964.1 KII66112.1 - 1.4e-16 59.8 10.6 1.4e-05 25.0 0.0 3.3 2 1 1 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII66112.1 - 4.9e-14 51.5 13.9 1.1e-06 28.0 0.3 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII66112.1 - 1.2e-13 50.6 5.6 7.3e-05 22.4 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII66112.1 - 1.6e-13 50.3 2.0 0.0049 16.9 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII66112.1 - 2.2e-09 37.0 5.0 0.027 14.4 0.2 3.4 3 1 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII66112.1 - 0.00018 21.1 4.4 0.23 11.2 0.3 3.3 3 0 0 3 3 3 2 Kelch motif Rax2 PF12768.2 KII66112.1 - 0.083 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Kelch_6 PF13964.1 KII66113.1 - 8.2e-29 98.5 20.1 6.9e-06 26.0 0.1 6.4 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII66113.1 - 4.6e-25 86.8 17.4 9.4e-05 21.8 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII66113.1 - 3.1e-22 78.0 15.5 0.00018 21.2 0.1 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KII66113.1 - 1.1e-20 73.1 9.0 0.0023 18.0 0.0 7.1 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII66113.1 - 3.9e-15 55.4 22.5 0.0002 21.2 0.0 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KII66113.1 - 2e-10 39.9 21.7 0.11 12.2 0.1 6.6 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII66114.1 - 7e-19 67.3 14.7 2.6e-07 30.2 0.1 6.0 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KII66114.1 - 2.8e-17 62.0 17.7 8.1e-06 25.7 0.4 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.20 KII66114.1 - 5e-17 61.1 17.5 1.8e-05 24.2 0.1 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.1 KII66114.1 - 3.6e-11 42.7 20.7 1.8e-05 24.5 0.5 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KII66114.1 - 1.3e-10 40.5 14.6 0.00031 20.3 0.2 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 KII66114.1 - 1.6e-06 28.1 17.9 0.35 11.1 0.0 6.4 6 1 1 7 7 7 3 Galactose oxidase, central domain DDE_3 PF13358.1 KII66115.1 - 0.00013 21.7 0.1 0.00069 19.3 0.0 1.8 1 1 1 2 2 2 1 DDE superfamily endonuclease E1_DerP2_DerF2 PF02221.10 KII66119.1 - 3.6e-05 24.0 0.0 4.8e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 ML domain FlpD PF02662.11 KII66119.1 - 0.13 11.9 0.2 0.26 11.0 0.1 1.4 1 1 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit E1_DerP2_DerF2 PF02221.10 KII66120.1 - 0.0022 18.2 0.1 0.0028 17.9 0.0 1.2 1 0 0 1 1 1 1 ML domain DDE_3 PF13358.1 KII66122.1 - 0.0015 18.2 0.1 0.003 17.2 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease LIM PF00412.17 KII66123.1 - 6.2e-26 90.2 45.9 1.7e-11 44.0 5.5 3.2 3 0 0 3 3 3 3 LIM domain PDZ PF00595.19 KII66123.1 - 1.5e-09 37.8 0.0 2.5e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII66123.1 - 0.0082 16.0 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain EBV-NA3 PF05009.7 KII66123.1 - 0.091 12.0 0.2 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) SAP PF02037.22 KII66125.1 - 1.7e-10 40.1 2.7 3e-10 39.3 1.9 1.4 1 0 0 1 1 1 1 SAP domain AAA_33 PF13671.1 KII66125.1 - 4.9e-10 39.4 0.0 1.1e-09 38.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain SPRY PF00622.23 KII66125.1 - 2.3e-05 24.4 0.6 4.8e-05 23.4 0.4 1.5 1 0 0 1 1 1 1 SPRY domain Arch_ATPase PF01637.13 KII66125.1 - 0.015 14.9 0.1 0.032 13.9 0.1 1.4 1 0 0 1 1 1 0 Archaeal ATPase Rho_N PF07498.7 KII66125.1 - 0.21 11.3 0.3 0.47 10.2 0.2 1.6 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain Sec3_C PF09763.4 KII66128.1 - 8.2e-18 63.9 8.3 1.1e-16 60.2 5.7 1.9 1 1 0 1 1 1 1 Exocyst complex component Sec3 PLAT PF01477.18 KII66129.1 - 4.5e-10 39.8 1.0 1.3e-09 38.3 0.1 2.1 2 1 1 3 3 3 1 PLAT/LH2 domain F5_F8_type_C PF00754.20 KII66129.1 - 1e-07 31.8 0.1 1.7e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 F5/8 type C domain F5_F8_type_C PF00754.20 KII66130.1 - 8.1e-31 106.5 0.1 1.1e-17 64.1 0.0 2.2 2 0 0 2 2 2 2 F5/8 type C domain Laminin_G_3 PF13385.1 KII66131.1 - 4.6e-18 65.9 0.0 8.6e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily TSP_1 PF00090.14 KII66131.1 - 6.1e-11 42.2 17.9 1.7e-06 28.0 3.5 2.4 2 0 0 2 2 2 2 Thrombospondin type 1 domain Pentaxin PF00354.12 KII66131.1 - 0.00017 21.0 0.0 0.0053 16.2 0.0 2.5 2 1 0 2 2 2 1 Pentaxin family Apis_Csd PF11671.3 KII66132.1 - 0.15 11.8 1.1 0.2 11.4 0.2 1.6 1 1 1 2 2 2 0 Complementary sex determiner protein zf-C2H2_jaz PF12171.3 KII66133.1 - 3.5e-05 23.8 7.8 3.5e-05 23.8 5.4 2.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KII66133.1 - 0.00019 21.5 6.3 0.00019 21.5 4.3 3.4 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 KII66133.1 - 0.00028 20.9 22.1 0.0089 16.1 3.4 3.3 2 1 1 3 3 3 3 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.7 KII66133.1 - 6.2 6.5 15.2 0.3 10.8 2.9 2.7 2 1 1 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) Thioredoxin PF00085.15 KII66134.1 - 3.9e-20 71.4 0.1 4.5e-20 71.2 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.11 KII66134.1 - 5.4e-06 25.9 0.1 6.1e-06 25.7 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_9 PF14595.1 KII66134.1 - 4.2e-05 23.1 0.2 4.8e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.1 KII66134.1 - 9.6e-05 22.1 0.0 0.00012 21.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain TrbC_Ftype PF09673.5 KII66134.1 - 0.0021 17.6 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 Type-F conjugative transfer system pilin assembly protein Thioredoxin_2 PF13098.1 KII66134.1 - 0.0078 16.4 0.1 0.053 13.7 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain KaiB PF07689.7 KII66134.1 - 0.011 15.2 0.1 0.019 14.4 0.0 1.6 2 0 0 2 2 2 0 KaiB domain DUF4504 PF14953.1 KII66134.1 - 0.021 14.1 0.1 0.033 13.4 0.0 1.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4504) Thioredoxin_6 PF13848.1 KII66134.1 - 0.035 13.9 0.5 0.048 13.4 0.4 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DUF914 PF06027.7 KII66135.1 - 1.7e-35 122.4 23.7 2.1e-35 122.1 16.4 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 KII66135.1 - 0.0017 18.4 12.5 0.0017 18.4 8.7 3.2 2 2 1 3 3 3 1 EamA-like transporter family EmrE PF13536.1 KII66135.1 - 0.0025 17.9 9.5 0.0025 17.9 6.6 3.4 1 1 2 3 3 3 1 Multidrug resistance efflux transporter UAA PF08449.6 KII66135.1 - 0.024 13.5 26.9 0.016 14.1 15.3 2.1 1 1 1 2 2 2 0 UAA transporter family DUF1632 PF07857.7 KII66135.1 - 2.2 7.4 16.2 0.05 12.8 4.5 2.7 2 1 0 2 2 2 0 CEO family (DUF1632) Cys_rich_FGFR PF00839.12 KII66137.1 - 0.078 12.9 0.4 12 5.8 0.0 2.5 2 1 0 2 2 2 0 Cysteine rich repeat TryThrA_C PF12319.3 KII66137.1 - 0.088 11.9 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-Threonine-rich plasmodium antigen C terminal DDE_Tnp_IS1595 PF12762.2 KII66138.1 - 1.4e-09 37.9 0.6 2.7e-09 37.0 0.1 1.6 2 0 0 2 2 2 1 ISXO2-like transposase domain HMG_box PF00505.14 KII66140.1 - 2.7e-36 123.6 14.2 5.7e-22 77.7 1.2 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 KII66140.1 - 1.3e-31 108.7 17.2 1e-18 67.4 2.4 2.4 2 0 0 2 2 2 2 HMG-box domain HMG_box_5 PF14887.1 KII66140.1 - 0.00025 20.7 3.5 0.00025 20.7 2.4 2.5 2 1 0 2 2 2 2 HMG (high mobility group) box 5 DUF1074 PF06382.6 KII66140.1 - 0.0077 16.2 13.8 0.11 12.5 4.7 2.6 1 1 0 2 2 2 2 Protein of unknown function (DUF1074) ArsC PF03960.10 KII66140.1 - 0.087 12.9 0.7 2 8.5 0.0 2.6 2 1 0 3 3 3 0 ArsC family Syntaxin_2 PF14523.1 KII66140.1 - 0.97 9.5 5.1 3.9 7.5 0.2 2.3 2 0 0 2 2 2 0 Syntaxin-like protein DUF1289 PF06945.8 KII66140.1 - 1.2 8.6 3.3 19 4.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) SIS PF01380.17 KII66141.1 - 1e-40 138.3 0.1 1.2e-24 86.4 0.0 2.5 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 KII66141.1 - 1.7e-17 63.2 0.4 5.8e-14 51.5 0.0 2.2 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 KII66141.1 - 2.7e-13 50.0 0.0 5.4e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 KII66141.1 - 2.2e-08 33.1 0.1 3.7e-08 32.3 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_7 PF13537.1 KII66141.1 - 2.1e-06 27.4 0.1 5.4e-06 26.1 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain SIS_2 PF13580.1 KII66141.1 - 0.0011 18.7 0.0 0.0028 17.3 0.0 1.7 1 0 0 1 1 1 1 SIS domain Pterin_4a PF01329.14 KII66141.1 - 0.065 12.9 0.1 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 Pterin 4 alpha carbinolamine dehydratase CLASP_N PF12348.3 KII66143.1 - 1.6e-07 30.9 0.1 1.5e-05 24.4 0.1 2.1 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.17 KII66143.1 - 0.00015 21.5 0.2 4.2 7.7 0.0 4.4 5 0 0 5 5 5 1 HEAT repeat MMS19_N PF14500.1 KII66143.1 - 0.0057 15.9 0.3 0.059 12.6 0.1 2.2 1 1 1 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II Adaptin_N PF01602.15 KII66143.1 - 0.013 13.8 0.4 0.041 12.2 0.3 1.9 1 1 0 1 1 1 0 Adaptin N terminal region TAN PF11640.3 KII66143.1 - 0.02 14.6 0.2 0.39 10.4 0.2 2.3 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair DUF1837 PF08878.6 KII66143.1 - 0.044 13.3 0.0 3.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1837) SEA PF01390.15 KII66144.1 - 1.5e-07 31.0 0.0 2.6e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 SEA domain Kelch_6 PF13964.1 KII66145.1 - 2e-21 75.2 11.5 2.2e-05 24.4 0.0 6.6 4 2 2 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KII66145.1 - 5.9e-20 70.5 11.4 8.8e-09 34.7 0.5 5.5 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 KII66145.1 - 1.1e-17 63.0 8.3 0.00014 21.4 0.1 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII66145.1 - 6.7e-16 57.8 20.9 9.3e-05 22.1 0.2 7.0 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII66145.1 - 1.1e-12 47.7 11.2 0.00065 19.7 0.0 5.9 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII66145.1 - 2.3e-12 46.5 7.4 0.055 13.4 0.1 4.7 4 0 0 4 4 4 4 Kelch motif DUF866 PF05907.8 KII66145.1 - 0.067 12.6 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) PAX PF00292.13 KII66146.1 - 9.3e-06 25.3 0.2 1.2e-05 25.0 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.1 KII66146.1 - 0.0097 16.0 0.1 0.012 15.7 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.1 KII66146.1 - 0.013 15.0 0.2 0.023 14.2 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1323 PF07037.6 KII66146.1 - 0.04 14.0 0.0 0.058 13.5 0.0 1.2 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) DDE_3 PF13358.1 KII66147.1 - 4.7e-06 26.4 0.0 9.2e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease OKR_DC_1_N PF03709.10 KII66147.1 - 0.13 12.3 0.1 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain SIS PF01380.17 KII66148.1 - 5e-33 113.4 0.1 2.5e-25 88.5 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 KII66148.1 - 2e-19 69.5 0.7 2.1e-15 56.3 0.1 2.2 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 KII66148.1 - 4.4e-13 49.3 0.0 8.3e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 KII66148.1 - 1.2e-09 37.2 0.1 2.2e-09 36.4 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_7 PF13537.1 KII66148.1 - 1.1e-06 28.3 0.0 2.5e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.1 KII66148.1 - 0.00017 21.3 0.0 0.00039 20.1 0.0 1.6 1 0 0 1 1 1 1 SIS domain Pterin_4a PF01329.14 KII66148.1 - 0.12 12.1 0.1 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase Acyltransferase PF01553.16 KII66149.1 - 1.6e-11 43.7 0.0 2.5e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase DUF2340 PF10209.4 KII66150.1 - 2.2e-21 76.2 0.0 2.5e-21 76.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) PI3_PI4_kinase PF00454.22 KII66151.1 - 1.8e-27 96.3 0.1 7.9e-27 94.2 0.1 1.9 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase NDUF_B7 PF05676.8 KII66151.1 - 0.096 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) PI3K_C2 PF00792.19 KII66152.1 - 1.2e-10 41.3 0.0 2.5e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3Ka PF00613.15 KII66152.1 - 5.7e-10 38.6 0.3 1.7e-09 37.0 0.3 1.7 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_p85B PF02192.11 KII66152.1 - 3.5e-05 23.1 0.3 0.013 14.8 0.2 3.1 2 0 0 2 2 2 2 PI3-kinase family, p85-binding domain DUF3733 PF12534.3 KII66153.1 - 6.4e-05 22.1 0.0 0.0002 20.5 0.0 1.9 1 0 0 1 1 1 1 Leucine-rich repeat containing protein 8 OTU PF02338.14 KII66153.1 - 0.0051 17.3 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Ribosomal_L3 PF00297.17 KII66154.1 - 2e-100 335.5 3.3 2.4e-100 335.2 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 DUF1664 PF07889.7 KII66155.1 - 3.7e-06 26.7 2.1 0.05 13.4 0.4 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) Thioredoxin PF00085.15 KII66155.1 - 0.00094 18.8 0.0 0.0032 17.1 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Laminin_II PF06009.7 KII66155.1 - 0.0016 18.2 7.4 0.026 14.2 0.5 2.8 1 1 2 3 3 3 2 Laminin Domain II Baculo_PEP_C PF04513.7 KII66155.1 - 0.01 15.6 10.1 0.01 15.6 7.0 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 KII66155.1 - 0.017 14.9 6.3 1.3 8.9 0.4 2.7 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.16 KII66155.1 - 0.035 13.6 1.2 0.4 10.1 0.2 2.3 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Spc7 PF08317.6 KII66155.1 - 0.067 11.8 1.2 0.25 9.9 0.1 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein NPV_P10 PF05531.7 KII66155.1 - 0.095 12.9 12.1 2.2 8.6 0.5 3.5 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein OSCP PF00213.13 KII66155.1 - 0.12 12.2 2.2 3 7.6 0.1 2.4 1 1 2 3 3 3 0 ATP synthase delta (OSCP) subunit Reo_sigmaC PF04582.7 KII66155.1 - 0.19 10.8 7.9 2.2 7.3 3.0 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Sec8_exocyst PF04048.9 KII66155.1 - 0.19 11.3 3.4 2.7 7.6 0.1 2.5 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain FlaC_arch PF05377.6 KII66155.1 - 1.1 9.2 8.4 14 5.6 0.1 4.2 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) SF-assemblin PF06705.6 KII66155.1 - 2.1 7.4 5.8 2 7.4 0.2 2.5 1 1 0 2 2 2 0 SF-assemblin/beta giardin DUF972 PF06156.8 KII66155.1 - 3.4 8.0 4.6 9.1 6.6 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Fib_alpha PF08702.5 KII66155.1 - 6.9 6.7 6.2 12 5.9 0.4 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Pkinase PF00069.20 KII66156.1 - 1.5e-06 27.6 0.0 2.5e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Aa_trans PF01490.13 KII66157.1 - 5.7e-36 123.8 20.3 7.4e-36 123.4 14.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Abhydrolase_9_N PF15420.1 KII66157.1 - 0.35 10.5 2.9 0.2 11.3 0.5 1.6 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Antimicrobial10 PF08105.6 KII66157.1 - 7.6 6.2 8.4 62 3.3 0.3 3.4 2 1 0 2 2 2 0 Metchnikowin family MFS_1 PF07690.11 KII66158.1 - 2.8e-20 72.3 39.0 3.2e-13 49.1 12.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KII66158.1 - 2.5e-06 26.1 23.8 2.5e-06 26.1 16.5 2.5 1 1 1 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.2 KII66158.1 - 3.2e-06 26.8 2.0 3.2e-06 26.8 1.4 4.2 4 1 1 5 5 5 2 MFS_1 like family Sugar_tr PF00083.19 KII66158.1 - 0.00021 19.9 27.0 0.039 12.5 1.8 3.0 2 1 0 2 2 2 2 Sugar (and other) transporter NfeD PF01957.13 KII66158.1 - 0.28 11.2 14.8 0.3 11.2 0.5 3.7 4 0 0 4 4 4 0 NfeD-like C-terminal, partner-binding MFS_3 PF05977.8 KII66158.1 - 0.54 8.3 5.8 0.27 9.2 0.2 2.3 3 0 0 3 3 3 0 Transmembrane secretion effector DUF4418 PF14387.1 KII66158.1 - 0.74 9.5 0.0 0.74 9.5 0.0 3.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4418) SGS PF05002.10 KII66161.1 - 2.7e-10 39.8 4.2 6.2e-10 38.6 2.9 1.6 1 0 0 1 1 1 1 SGS domain CS PF04969.11 KII66161.1 - 6.8e-10 39.3 0.7 6.8e-10 39.3 0.5 1.7 2 0 0 2 2 2 1 CS domain Siah-Interact_N PF09032.6 KII66161.1 - 0.00074 19.5 0.5 0.0017 18.3 0.3 1.6 1 0 0 1 1 1 1 Siah interacting protein, N terminal PAP2_C PF14360.1 KII66162.1 - 6e-20 71.2 14.9 1.1e-19 70.5 10.3 1.4 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PAP2 PF01569.16 KII66162.1 - 1.2e-08 34.6 7.0 1.8e-08 34.1 4.8 1.2 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.1 KII66162.1 - 6.9e-06 25.7 3.4 9.7e-06 25.2 2.4 1.2 1 0 0 1 1 1 1 PAP2 superfamily SdpI PF13630.1 KII66162.1 - 8 6.2 11.9 0.23 11.1 2.7 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family UAA PF08449.6 KII66163.1 - 1.3e-53 181.9 16.9 1.4e-53 181.7 11.7 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 KII66163.1 - 7.6e-13 48.6 18.8 1.1e-12 48.1 7.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 KII66163.1 - 4e-08 33.0 14.5 4e-08 33.0 10.0 2.0 2 0 0 2 2 2 1 Triose-phosphate Transporter family EmrE PF13536.1 KII66163.1 - 1e-05 25.6 14.0 4.5e-05 23.6 7.3 2.2 2 0 0 2 2 2 1 Multidrug resistance efflux transporter Nuc_sug_transp PF04142.10 KII66163.1 - 0.00013 21.1 2.2 0.062 12.4 0.1 2.1 1 1 1 2 2 2 2 Nucleotide-sugar transporter DUF962 PF06127.6 KII66163.1 - 0.0059 16.4 1.0 0.0098 15.7 0.1 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF962) DUF2085 PF09858.4 KII66163.1 - 0.11 12.5 3.5 0.19 11.8 0.5 2.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2085) 7tm_1 PF00001.16 KII66165.1 - 2.4e-09 36.7 5.9 2.8e-09 36.5 4.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.4 KII66165.1 - 2.9e-07 29.9 8.5 3.7e-07 29.5 5.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.16 KII66166.1 - 7.5e-15 54.7 18.6 1.1e-14 54.2 12.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2681 PF10883.3 KII66166.1 - 0.43 10.8 2.6 11 6.3 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Vpu PF00558.14 KII66166.1 - 0.67 9.5 11.9 0.17 11.4 3.7 2.3 2 0 0 2 2 2 0 Vpu protein 7tm_1 PF00001.16 KII66167.1 - 1.3e-09 37.5 10.4 1.3e-09 37.5 7.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FLYWCH PF04500.11 KII66168.1 - 0.00017 21.3 0.4 0.00031 20.5 0.3 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain SBP_bac_5 PF00496.17 KII66168.1 - 0.094 11.5 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle Tetraspannin PF00335.15 KII66170.1 - 0.0034 16.6 15.8 0.0079 15.4 10.9 1.6 1 1 0 1 1 1 1 Tetraspanin family Caa3_CtaG PF09678.5 KII66170.1 - 0.12 11.3 10.3 0.013 14.3 2.7 2.3 1 1 2 3 3 3 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) STT3 PF02516.9 KII66170.1 - 0.25 10.2 11.5 1.3 7.9 8.0 1.8 1 1 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit DUF1673 PF07895.6 KII66170.1 - 2.5 7.5 10.4 3.8 6.9 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) ATP_synt_H PF05493.8 KII66170.1 - 4.7 7.3 9.6 0.67 10.0 2.0 2.4 2 1 0 2 2 2 0 ATP synthase subunit H 7tm_1 PF00001.16 KII66171.1 - 1.9e-07 30.5 1.9 2.3e-07 30.2 1.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_2 PF00002.19 KII66171.1 - 0.026 13.5 1.1 0.044 12.8 0.8 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) DUF4083 PF13314.1 KII66171.1 - 0.47 10.3 4.2 1.1 9.0 1.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) 7tm_1 PF00001.16 KII66172.1 - 4e-06 26.1 4.7 5.1e-06 25.8 3.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.16 KII66173.1 - 1.3e-13 50.6 7.4 1.8e-13 50.2 5.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.4 KII66173.1 - 1.5e-06 27.5 12.2 1.7e-06 27.3 8.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv HTH_29 PF13551.1 KII66174.1 - 0.0024 17.9 0.1 0.028 14.5 0.1 2.0 1 1 1 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.1 KII66174.1 - 0.01 16.6 0.6 0.038 14.7 0.2 1.9 1 1 1 2 2 2 0 Homeodomain-like domain HTH_33 PF13592.1 KII66174.1 - 0.012 15.1 0.0 0.027 14.0 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix PAX PF00292.13 KII66174.1 - 0.018 14.7 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 'Paired box' domain B5 PF03484.10 KII66174.1 - 0.054 13.3 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase B5 domain 7tm_1 PF00001.16 KII66175.1 - 5.7e-12 45.3 8.8 7e-12 45.0 6.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.4 KII66175.1 - 4.3e-05 22.7 13.4 5e-05 22.5 9.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv AMP-binding PF00501.23 KII66177.1 - 5.5e-48 163.3 0.0 6.9e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme SAD_SRA PF02182.12 KII66177.1 - 0.056 12.7 0.1 0.086 12.1 0.1 1.2 1 0 0 1 1 1 0 SAD/SRA domain UCH PF00443.24 KII66179.1 - 1.3e-24 86.7 0.1 1.7e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PAZ PF02170.17 KII66179.1 - 0.068 12.4 0.2 0.11 11.7 0.1 1.5 1 0 0 1 1 1 0 PAZ domain Sdh_cyt PF01127.17 KII66180.1 - 3.4e-23 81.7 5.8 4.3e-23 81.4 4.0 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Ribosomal_L3 PF00297.17 KII66181.1 - 2.7e-53 181.0 0.6 3.4e-53 180.7 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 AhpC-TSA PF00578.16 KII66182.1 - 1.3e-22 79.7 0.0 1.8e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KII66182.1 - 3.2e-05 23.5 0.0 3.8e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 KII66182.1 - 0.15 11.6 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain of 1-Cys peroxiredoxin DUF4078 PF13300.1 KII66183.1 - 3e-10 40.0 13.9 3.2e-10 39.9 6.2 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4078) Hemolysin_N PF12563.3 KII66183.1 - 0.09 12.1 0.5 0.2 11.0 0.2 1.7 1 1 0 1 1 1 0 Hemolytic toxin N terminal Glyco_tran_WbsX PF14307.1 KII66184.1 - 0.071 12.2 0.1 0.074 12.2 0.1 1.0 1 0 0 1 1 1 0 Glycosyltransferase WbsX Nckap1 PF09735.4 KII66185.1 - 2e-19 68.6 1.7 2e-19 68.6 1.2 1.9 1 1 1 2 2 2 2 Membrane-associated apoptosis protein MSC PF09402.5 KII66186.1 - 6.6e-13 48.0 2.5 1.3e-12 47.1 1.8 1.5 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain LEM PF03020.10 KII66186.1 - 2.5e-12 46.0 0.3 5.7e-12 44.8 0.2 1.6 1 0 0 1 1 1 1 LEM domain Brix PF04427.13 KII66187.1 - 1.4e-44 152.0 1.2 1.8e-44 151.6 0.8 1.1 1 0 0 1 1 1 1 Brix domain Ran-binding PF05508.6 KII66187.1 - 0.05 12.4 0.0 0.085 11.7 0.0 1.3 1 0 0 1 1 1 0 RanGTP-binding protein TCR PF03638.10 KII66188.1 - 8.5e-25 86.3 52.4 3.9e-13 49.0 16.5 2.4 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain XPG_I PF00867.13 KII66188.1 - 0.028 14.4 0.3 0.081 12.9 0.0 1.8 2 0 0 2 2 2 0 XPG I-region Glyco_transf_10 PF00852.14 KII66189.1 - 3.8e-39 134.2 7.0 4.7e-39 133.9 4.8 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) DDE_Tnp_IS1595 PF12762.2 KII66190.1 - 0.00026 20.8 0.1 0.00043 20.1 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF4369 PF14289.1 KII66190.1 - 0.048 13.6 0.1 1 9.4 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4369) DUF1759 PF03564.10 KII66191.1 - 3.5e-06 26.9 0.0 4.9e-06 26.4 0.0 1.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1759) Adap_comp_sub PF00928.16 KII66192.1 - 0.022 13.8 0.1 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Adaptor complexes medium subunit family ETRAMP PF09716.5 KII66192.1 - 0.13 12.2 0.2 0.26 11.2 0.2 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.27 KII66193.1 - 7.8e-19 66.7 2.1 6.3e-06 25.8 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 KII66193.1 - 6.1e-07 29.3 0.0 0.044 13.5 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Trehalase PF01204.13 KII66193.1 - 0.18 10.4 0.0 0.33 9.5 0.0 1.3 1 0 0 1 1 1 0 Trehalase Cpn60_TCP1 PF00118.19 KII66194.1 - 4e-12 45.5 0.1 5.8e-12 44.9 0.1 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PIP5K PF01504.13 KII66195.1 - 6.3e-45 153.2 6.8 1.9e-44 151.6 4.7 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF4573 PF15140.1 KII66195.1 - 0.0019 17.8 0.7 0.021 14.4 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4573) 7tm_1 PF00001.16 KII66196.1 - 1.1e-22 80.3 18.2 1.1e-22 80.3 12.6 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.4 KII66196.1 - 0.00015 20.9 29.0 0.00022 20.4 20.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx FLILHELTA PF10306.4 KII66196.1 - 0.25 11.3 0.1 0.25 11.3 0.1 2.8 3 0 0 3 3 3 0 Hypothetical protein FLILHELTA 7TM_GPCR_Srx PF10328.4 KII66196.1 - 0.69 8.9 35.3 0.031 13.3 14.7 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx MSC PF09402.5 KII66196.1 - 0.69 8.5 3.5 3.1 6.4 0.1 2.5 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain DUF4446 PF14584.1 KII66196.1 - 3.8 7.3 8.0 2.5 7.9 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) Ldl_recept_a PF00057.13 KII66197.1 - 2.5e-09 36.8 23.6 2e-07 30.8 9.6 2.8 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A HIG_1_N PF04588.8 KII66197.1 - 0.0002 21.0 0.1 0.00041 20.0 0.0 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region BNR PF02012.15 KII66198.1 - 0.29 11.1 6.3 3.4 7.8 0.0 3.3 3 0 0 3 3 3 0 BNR/Asp-box repeat rve PF00665.21 KII66199.1 - 7.4e-21 74.4 1.3 1.5e-20 73.4 0.3 2.0 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII66199.1 - 8.9e-05 21.9 0.0 0.0002 20.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DUF4129 PF13559.1 KII66199.1 - 0.0082 16.0 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) HAT PF02184.11 KII66200.1 - 1.5e-33 114.1 71.3 3.9e-17 61.6 3.6 14.0 14 2 0 14 14 14 9 HAT (Half-A-TPR) repeat TPR_14 PF13428.1 KII66200.1 - 6.1e-18 63.6 10.4 1.1 10.0 0.0 11.9 6 3 7 13 13 12 3 Tetratricopeptide repeat TPR_16 PF13432.1 KII66200.1 - 1.3e-12 48.0 3.5 0.1 13.3 0.0 6.7 6 2 1 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 KII66200.1 - 2.2e-09 37.5 0.0 0.3 11.4 0.0 6.0 4 1 2 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 KII66200.1 - 2.2e-07 30.5 0.5 0.0015 18.5 0.1 4.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII66200.1 - 3.6e-07 29.6 8.3 0.99 9.4 0.0 8.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII66200.1 - 1.4e-05 24.9 8.4 0.3 11.0 0.0 7.1 8 1 0 8 8 8 1 Tetratricopeptide repeat TPR_8 PF13181.1 KII66200.1 - 3.8e-05 23.1 2.3 40 4.3 0.6 7.0 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 KII66200.1 - 0.00016 21.8 8.4 4.3 8.0 0.0 8.2 9 1 1 10 10 8 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII66200.1 - 0.0012 18.4 5.3 0.023 14.3 0.1 4.2 5 2 1 6 6 5 1 TPR repeat Mad3_BUB1_I PF08311.7 KII66200.1 - 0.0034 17.1 18.0 0.92 9.3 2.4 5.5 4 2 2 6 6 6 3 Mad3/BUB1 homology region 1 U3_assoc_6 PF08640.6 KII66200.1 - 0.038 13.7 21.7 0.075 12.8 0.5 6.7 5 2 1 6 6 6 0 U3 small nucleolar RNA-associated protein 6 TPR_9 PF13371.1 KII66200.1 - 0.075 12.8 5.1 1.2 9.0 0.1 4.2 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII66200.1 - 0.34 10.8 12.6 5.3 7.0 0.0 7.2 10 0 0 10 10 9 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.11 KII66200.1 - 6.3 6.6 8.2 3.1 7.6 0.6 3.7 4 0 0 4 4 4 0 Exonuclease VII small subunit HEAT_2 PF13646.1 KII66201.1 - 5e-07 29.9 0.0 0.026 14.7 0.0 3.7 2 1 1 3 3 3 2 HEAT repeats Arm PF00514.18 KII66201.1 - 1.2e-05 24.9 0.6 1.4 8.8 0.0 4.7 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KII66201.1 - 2.2e-05 24.1 0.0 1 9.6 0.0 4.7 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 KII66201.1 - 0.0025 18.2 0.0 0.055 13.9 0.0 2.8 3 1 0 3 3 3 1 HEAT-like repeat R3H PF01424.17 KII66202.1 - 0.03 14.0 0.6 0.089 12.4 0.0 1.9 2 0 0 2 2 2 0 R3H domain HTH_32 PF13565.1 KII66202.1 - 0.086 13.6 0.0 0.11 13.3 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain DUF977 PF06163.6 KII66202.1 - 0.16 11.7 0.8 0.25 11.0 0.1 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF977) MFS_1 PF07690.11 KII66203.1 - 5.4e-20 71.3 22.6 7.9e-20 70.8 15.7 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Pox_A14 PF05767.7 KII66203.1 - 0.18 11.7 2.5 5.8 6.9 0.4 2.6 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 PsbX PF06596.6 KII66203.1 - 0.8 9.4 3.7 21 4.9 0.1 3.0 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) RhoGAP PF00620.22 KII66204.1 - 6e-23 81.1 0.0 8.9e-23 80.5 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DUF4563 PF15124.1 KII66205.1 - 0.035 13.6 0.0 0.035 13.6 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4563) PK PF00224.16 KII66206.1 - 1.2e-91 306.9 3.8 1.5e-91 306.6 2.6 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KII66206.1 - 2.2e-27 94.9 0.3 1.1e-26 92.6 0.1 2.2 1 1 1 2 2 2 1 Pyruvate kinase, alpha/beta domain Tetraspannin PF00335.15 KII66207.1 - 0.0046 16.2 7.9 0.0085 15.3 5.5 1.5 1 0 0 1 1 1 1 Tetraspanin family Amastin PF07344.6 KII66207.1 - 1 8.9 12.2 0.042 13.4 3.2 2.2 1 1 1 2 2 2 0 Amastin surface glycoprotein EGF_2 PF07974.8 KII66208.1 - 2.9e-05 24.1 17.7 2.9e-05 24.1 12.3 4.6 2 2 2 4 4 4 2 EGF-like domain hEGF PF12661.2 KII66208.1 - 0.0046 16.9 3.5 0.0046 16.9 2.5 3.9 5 0 0 5 5 5 1 Human growth factor-like EGF Fer4_12 PF13353.1 KII66209.1 - 0.01 15.9 0.1 0.011 15.8 0.0 1.1 1 0 0 1 1 1 0 4Fe-4S single cluster domain SH2 PF00017.19 KII66209.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 SH2 domain zf-C2H2 PF00096.21 KII66210.1 - 1.5e-11 43.9 72.2 0.0041 17.3 3.5 8.3 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII66210.1 - 2e-11 43.3 66.1 0.0015 18.7 0.8 8.1 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII66210.1 - 2.1e-11 43.6 51.4 0.0016 18.5 1.0 7.5 7 0 0 7 7 7 6 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 KII66210.1 - 1e-08 35.0 57.2 0.00024 21.2 3.6 9.9 10 1 0 10 10 10 4 Zinc-finger double domain zf-met PF12874.2 KII66210.1 - 0.00067 19.7 32.7 0.02 15.0 0.5 6.3 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.1 KII66210.1 - 1.2 9.5 42.2 0.32 11.2 2.6 6.6 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zf-BED PF02892.10 KII66210.1 - 1.3 8.8 43.6 7.5 6.4 0.1 7.4 5 2 1 6 6 6 0 BED zinc finger GAGA PF09237.6 KII66210.1 - 1.9 8.1 0.0 1.9 8.1 0.0 6.1 6 1 1 7 7 7 0 GAGA factor Desulfoferrod_N PF06397.7 KII66210.1 - 4.3 6.8 6.8 11 5.5 0.7 3.0 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Ribosomal_S27 PF01599.14 KII66211.1 - 9.8e-20 70.1 4.4 4.4e-19 68.0 2.2 2.2 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.3 KII66211.1 - 6e-07 29.0 0.7 7.9e-07 28.6 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KII66211.1 - 2.3e-05 23.7 0.1 2.3e-05 23.7 0.1 1.9 2 1 1 3 3 3 1 Ubiquitin family DUF4448 PF14610.1 KII66212.1 - 0.00075 19.0 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF912 PF06024.7 KII66212.1 - 0.0018 18.3 0.3 0.0032 17.4 0.0 1.6 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3377 PF11857.3 KII66212.1 - 0.0097 15.5 0.1 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) TMEM154 PF15102.1 KII66212.1 - 0.024 14.3 0.6 0.043 13.5 0.4 1.4 1 1 0 1 1 1 0 TMEM154 protein family DUF4519 PF15012.1 KII66212.1 - 0.18 11.7 0.6 0.39 10.6 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Vpu PF00558.14 KII66212.1 - 2.8 7.5 4.6 2.3 7.8 1.6 2.0 2 0 0 2 2 2 0 Vpu protein DUF912 PF06024.7 KII66213.1 - 0.00046 20.1 2.9 0.0087 16.0 2.0 2.3 1 1 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4448 PF14610.1 KII66213.1 - 0.0083 15.6 0.7 0.015 14.7 0.1 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF4448) Rifin_STEVOR PF02009.11 KII66213.1 - 0.015 14.9 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Rifin/stevor family DUF3377 PF11857.3 KII66213.1 - 0.046 13.3 0.0 0.13 11.9 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) CDC45 PF02724.9 KII66213.1 - 7.4 4.4 8.2 9.6 4.0 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Metallophos_2 PF12850.2 KII66215.1 - 0.0028 17.4 0.5 0.0049 16.7 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain HTH_23 PF13384.1 KII66215.1 - 0.0085 15.7 0.0 0.032 13.8 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain Toxin_64 PF15542.1 KII66215.1 - 0.018 15.5 2.6 0.095 13.2 1.8 2.1 1 1 0 1 1 1 0 Putative toxin 64 Metallophos PF00149.23 KII66215.1 - 0.48 9.7 9.5 6.4 6.1 6.5 2.5 2 1 0 2 2 2 0 Calcineurin-like phosphoesterase Serpin PF00079.15 KII66218.1 - 4.8e-56 190.4 1.6 6e-56 190.1 1.1 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cornichon PF03311.9 KII66218.1 - 0.079 13.1 0.4 0.21 11.7 0.1 1.8 2 0 0 2 2 2 0 Cornichon protein Plant_zn_clust PF10533.4 KII66220.1 - 1.4 8.6 4.3 0.47 10.1 0.4 2.0 2 1 1 3 3 3 0 Plant zinc cluster domain BNR PF02012.15 KII66222.1 - 4.1e-07 28.8 0.2 2.1 8.4 0.0 3.9 3 0 0 3 3 3 3 BNR/Asp-box repeat Mo-co_dimer PF03404.11 KII66222.1 - 0.0054 16.3 0.0 7 6.3 0.0 3.0 1 1 1 3 3 3 2 Mo-co oxidoreductase dimerisation domain RNA_pol_Rpb2_4 PF04566.8 KII66224.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 4 BNR PF02012.15 KII66225.1 - 7e-07 28.1 3.2 0.82 9.7 0.1 5.9 5 0 0 5 5 5 3 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII66225.1 - 2.6e-05 24.0 7.7 2.6e-05 24.0 5.3 3.2 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII66227.1 - 1.5e-07 30.1 0.5 0.065 13.0 0.1 4.0 3 0 0 3 3 3 3 BNR/Asp-box repeat Mo-co_dimer PF03404.11 KII66227.1 - 0.014 14.9 0.0 1.3 8.6 0.0 3.0 3 0 0 3 3 3 0 Mo-co oxidoreductase dimerisation domain DnaI_N PF07319.6 KII66229.1 - 0.02 15.1 0.3 0.025 14.8 0.2 1.1 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus Adeno_E3_CR1 PF02440.10 KII66234.1 - 0.0096 15.3 4.0 0.9 9.0 0.5 2.3 2 0 0 2 2 2 2 Adenovirus E3 region protein CR1 SRPRB PF09439.5 KII66236.1 - 3.5e-20 71.9 0.4 4.4e-20 71.6 0.3 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 KII66236.1 - 9e-09 34.8 0.1 1.1e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family IstB_IS21 PF01695.12 KII66236.1 - 0.00021 20.7 0.2 0.65 9.3 0.1 2.3 2 1 0 2 2 2 2 IstB-like ATP binding protein GTP_EFTU PF00009.22 KII66236.1 - 0.00059 19.3 0.4 0.00083 18.8 0.3 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA PF00004.24 KII66236.1 - 0.0063 16.7 1.3 0.027 14.6 0.9 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.10 KII66236.1 - 0.012 15.4 0.9 0.041 13.7 0.6 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Miro PF08477.8 KII66236.1 - 0.014 15.8 0.1 0.028 14.8 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_33 PF13671.1 KII66236.1 - 0.061 13.2 0.0 0.089 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 KII66236.1 - 0.063 12.4 0.6 2.1 7.5 0.0 2.7 3 1 0 3 3 3 0 PhoH-like protein CCT_2 PF09425.5 KII66237.1 - 0.036 13.6 0.6 0.072 12.6 0.4 1.4 1 0 0 1 1 1 0 Divergent CCT motif NADH_oxidored PF08040.6 KII66237.1 - 0.12 12.0 0.0 0.32 10.6 0.0 1.8 1 0 0 1 1 1 0 MNLL subunit DUF1064 PF06356.6 KII66239.1 - 0.036 14.0 0.0 0.053 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1064) zf-C4H2 PF10146.4 KII66240.1 - 0.0044 17.0 0.1 0.0049 16.9 0.1 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein CH PF00307.26 KII66241.1 - 3e-17 62.6 0.0 4.3e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.13 KII66241.1 - 1.4e-07 30.7 1.6 2.7e-07 29.8 1.1 1.5 1 0 0 1 1 1 1 Calponin family repeat CAMSAP_CH PF11971.3 KII66241.1 - 0.00022 20.8 0.1 0.0004 19.9 0.1 1.4 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.6 KII66241.1 - 0.00034 20.6 0.7 0.00055 19.9 0.5 1.3 1 0 0 1 1 1 1 CDC24 Calponin NEMO PF11577.3 KII66241.1 - 0.065 12.9 0.2 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO HHH_4 PF14490.1 KII66241.1 - 0.067 12.9 0.2 5.5 6.8 0.0 2.6 2 1 0 2 2 2 0 Helix-hairpin-helix containing domain Macro PF01661.16 KII66243.1 - 3.4e-05 23.7 0.0 6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Macro domain DUF1365 PF07103.6 KII66243.1 - 0.11 11.5 0.3 6.4 5.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1365) E2 PF08199.6 KII66244.1 - 0.043 13.4 1.2 0.081 12.5 0.9 1.4 1 0 0 1 1 1 0 Bacteriophage E2-like protein P5CR_dimer PF14748.1 KII66245.1 - 0.16 11.9 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation Ldl_recept_a PF00057.13 KII66246.1 - 3.8e-35 119.5 114.0 1.8e-10 40.4 7.6 7.4 7 1 0 7 7 7 6 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.1 KII66246.1 - 6.9e-05 22.8 3.9 6.9e-05 22.8 2.7 5.7 6 0 0 6 6 6 1 Coagulation Factor Xa inhibitory site PTPS_related PF10131.4 KII66246.1 - 0.08 11.0 0.1 0.11 10.6 0.0 1.1 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein BNR PF02012.15 KII66247.1 - 1.8e-05 23.8 7.5 0.048 13.4 0.5 3.8 3 0 0 3 3 3 3 BNR/Asp-box repeat DDE_3 PF13358.1 KII66249.1 - 3.3e-06 26.9 0.0 7.4e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease CENP-B_N PF04218.8 KII66249.1 - 0.0016 17.8 0.0 0.0032 16.8 0.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.1 KII66249.1 - 0.09 12.7 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Glycos_transf_2 PF00535.21 KII66250.1 - 9.5e-08 31.9 0.1 1.6e-07 31.1 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII66250.1 - 4.3e-05 23.4 0.0 0.0001 22.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KII66250.1 - 0.0019 17.9 0.0 0.0022 17.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Pox_P35 PF03213.9 KII66250.1 - 0.015 14.2 0.0 0.024 13.6 0.0 1.2 1 0 0 1 1 1 0 Poxvirus P35 protein Glyco_tranf_2_2 PF10111.4 KII66250.1 - 0.015 14.3 2.6 0.028 13.5 1.7 1.4 1 1 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_tranf_2_5 PF13712.1 KII66250.1 - 0.031 13.5 0.3 0.035 13.3 0.2 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family Borrelia_lipo_2 PF06238.6 KII66250.1 - 0.29 11.2 2.8 1.3 9.1 1.1 2.3 1 1 1 2 2 2 0 Borrelia burgdorferi BBR25 lipoprotein ICE2 PF08426.5 KII66251.1 - 0.015 13.9 0.2 0.018 13.6 0.1 1.1 1 0 0 1 1 1 0 ICE2 SnoaL_2 PF12680.2 KII66253.1 - 3.4e-07 30.6 0.0 5.5e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 KII66253.1 - 0.015 15.5 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) SnoaL_4 PF13577.1 KII66253.1 - 0.052 13.4 0.0 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 SnoaL-like domain SnoaL PF07366.7 KII66253.1 - 0.069 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase SnoaL_3 PF13474.1 KII66253.1 - 0.15 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain MarR PF01047.17 KII66254.1 - 2e-11 43.4 0.0 4.6e-11 42.2 0.0 1.7 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.1 KII66254.1 - 5.4e-08 33.0 0.0 1.1e-07 32.0 0.0 1.5 2 0 0 2 2 2 1 Winged helix DNA-binding domain MarR_2 PF12802.2 KII66254.1 - 3.8e-07 29.6 0.0 1e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 MarR family HTH_45 PF14947.1 KII66254.1 - 9.7e-05 22.1 0.0 0.00016 21.3 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_34 PF13601.1 KII66254.1 - 0.0002 21.3 0.0 0.00035 20.5 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.14 KII66254.1 - 0.00031 20.3 0.0 0.00053 19.6 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 KII66254.1 - 0.00099 18.4 0.0 0.0032 16.8 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding DUF2513 PF10711.4 KII66254.1 - 0.0011 18.9 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Hypothetical protein (DUF2513) HTH_IclR PF09339.5 KII66254.1 - 0.0017 17.9 0.0 0.0036 16.8 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_20 PF12840.2 KII66254.1 - 0.043 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain YjcQ PF09639.5 KII66254.1 - 0.05 13.6 0.0 0.097 12.7 0.0 1.5 1 0 0 1 1 1 0 YjcQ protein HTH_5 PF01022.15 KII66254.1 - 0.068 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_36 PF13730.1 KII66254.1 - 0.072 13.2 0.0 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain rve PF00665.21 KII66255.1 - 7.6e-11 42.1 0.0 1.6e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII66255.1 - 0.00017 21.0 0.0 0.00061 19.2 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_4 PF14392.1 KII66256.1 - 3.4e-05 23.4 9.4 0.012 15.2 0.9 2.8 1 1 1 2 2 2 2 Zinc knuckle Retrotrans_gag PF03732.12 KII66256.1 - 0.0034 17.4 0.0 0.0078 16.2 0.0 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein Gag_p24 PF00607.15 KII66256.1 - 0.0042 16.6 0.1 0.01 15.3 0.0 1.6 2 0 0 2 2 2 1 gag gene protein p24 (core nucleocapsid protein) zf-CCHC PF00098.18 KII66256.1 - 0.018 14.9 1.4 0.018 14.9 1.0 2.9 4 0 0 4 4 4 0 Zinc knuckle DUF2852 PF11014.3 KII66256.1 - 0.041 13.8 0.0 0.076 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) zf-TRAF PF02176.13 KII66256.1 - 0.2 12.0 4.6 0.56 10.6 3.2 1.8 1 1 0 1 1 1 0 TRAF-type zinc finger zf-CCHC_3 PF13917.1 KII66256.1 - 1.1 9.1 7.9 0.68 9.7 4.0 1.8 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.21 KII66258.1 - 2e-28 98.8 0.3 4.8e-28 97.6 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII66258.1 - 2.6e-05 23.6 0.1 7.4e-05 22.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII66258.1 - 0.061 13.2 0.9 0.59 10.0 0.0 2.4 3 0 0 3 3 3 0 DDE domain Peptidase_S37 PF05576.6 KII66258.1 - 0.11 10.9 0.0 0.14 10.5 0.0 1.1 1 0 0 1 1 1 0 PS-10 peptidase S37 CRA PF06589.6 KII66260.1 - 0.038 13.3 0.0 0.043 13.1 0.0 1.1 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) IncA PF04156.9 KII66260.1 - 0.045 13.3 0.3 7 6.2 0.0 2.0 1 1 1 2 2 2 0 IncA protein ATG16 PF08614.6 KII66261.1 - 0.025 14.3 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) OTU PF02338.14 KII66261.1 - 0.09 13.3 0.4 0.18 12.3 0.1 1.6 1 1 1 2 2 2 0 OTU-like cysteine protease Piwi PF02171.12 KII66263.1 - 6.9e-65 218.9 1.0 1.4e-64 217.9 0.7 1.5 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 KII66263.1 - 3e-15 55.7 0.6 7.2e-15 54.4 0.5 1.6 1 0 0 1 1 1 1 PAZ domain DUF2703 PF10865.3 KII66263.1 - 0.051 13.5 0.0 0.17 11.7 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) Anticodon_1 PF08264.8 KII66263.1 - 0.056 13.2 0.3 0.36 10.5 0.1 2.4 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA E2_bind PF08825.5 KII66263.1 - 0.11 12.3 0.1 1.6 8.5 0.0 2.5 2 0 0 2 2 2 0 E2 binding domain DDE_3 PF13358.1 KII66265.1 - 1.6e-11 44.1 0.0 2.8e-11 43.3 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease Adap_comp_sub PF00928.16 KII66265.1 - 0.011 14.8 0.0 0.012 14.7 0.0 1.1 1 0 0 1 1 1 0 Adaptor complexes medium subunit family AMP-binding PF00501.23 KII66266.1 - 0.00065 18.2 0.0 0.00078 17.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Hexapep PF00132.19 KII66267.1 - 3.8e-05 22.9 14.3 0.00011 21.5 1.9 3.9 2 1 2 4 4 4 2 Bacterial transferase hexapeptide (six repeats) FAD_binding_4 PF01565.18 KII66268.1 - 7.6e-19 67.5 0.0 9.1e-19 67.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.9 KII66269.1 - 7.8e-10 38.7 0.2 1.7e-06 27.8 0.1 2.1 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase BBE PF08031.7 KII66269.1 - 0.0013 18.5 0.4 0.0034 17.2 0.1 1.8 1 1 0 1 1 1 1 Berberine and berberine like Cut8_M PF14483.1 KII66270.1 - 0.0049 16.6 0.2 0.041 13.6 0.1 2.2 2 0 0 2 2 2 1 Cut8 dimerisation domain Rab5-bind PF09311.6 KII66270.1 - 0.023 14.5 0.8 0.023 14.5 0.6 1.4 1 1 0 1 1 1 0 Rabaptin-like protein TMF_DNA_bd PF12329.3 KII66270.1 - 0.033 13.9 2.4 0.033 13.9 1.7 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3375 PF11855.3 KII66270.1 - 0.042 12.6 2.0 0.055 12.2 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) Shugoshin_N PF07558.6 KII66270.1 - 0.049 13.3 1.5 0.11 12.1 1.0 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region DUF4473 PF14747.1 KII66270.1 - 0.049 13.8 0.7 0.12 12.5 0.1 1.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4473) Sigma54_AID PF00309.15 KII66270.1 - 0.084 12.3 0.2 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) Seryl_tRNA_N PF02403.17 KII66270.1 - 0.1 12.6 4.1 0.23 11.4 2.8 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Syntaxin PF00804.20 KII66270.1 - 0.11 12.6 4.2 0.19 11.9 2.9 1.4 1 0 0 1 1 1 0 Syntaxin HALZ PF02183.13 KII66270.1 - 0.12 12.0 0.9 1.4 8.6 0.3 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper DMPK_coil PF08826.5 KII66270.1 - 0.13 12.1 5.4 5.8 6.8 0.3 2.5 1 1 1 2 2 2 0 DMPK coiled coil domain like RTX_C PF08339.5 KII66270.1 - 0.17 11.5 2.5 0.21 11.2 1.8 1.1 1 0 0 1 1 1 0 RTX C-terminal domain VPS11_C PF12451.3 KII66270.1 - 0.22 11.3 0.1 0.22 11.3 0.1 2.4 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal bZIP_1 PF00170.16 KII66270.1 - 0.44 10.5 3.1 0.21 11.5 0.4 1.8 2 0 0 2 2 2 0 bZIP transcription factor Dynamin_N PF00350.18 KII66271.1 - 5.8e-06 26.2 1.7 1.5e-05 24.8 0.0 2.5 2 1 0 2 2 2 1 Dynamin family BTB_2 PF02214.17 KII66272.1 - 9.4e-10 38.5 0.0 1.9e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain AA_permease_2 PF13520.1 KII66273.1 - 3.2e-41 141.2 38.3 4e-41 140.9 26.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII66273.1 - 1.7e-22 79.4 39.5 2.1e-22 79.1 27.4 1.2 1 0 0 1 1 1 1 Amino acid permease Tmemb_cc2 PF10267.4 KII66273.1 - 2.7 6.5 3.6 5.2 5.5 2.5 1.4 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein FAM60A PF15396.1 KII66274.1 - 5.7e-08 32.7 0.1 9.6e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Protein Family FAM60A DUF3753 PF12575.3 KII66275.1 - 0.033 13.9 0.3 0.48 10.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) FixQ PF05545.6 KII66275.1 - 0.57 9.8 5.4 1.2 8.8 3.7 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Annexin PF00191.15 KII66276.1 - 0.014 15.2 0.6 0.79 9.6 0.1 2.3 2 0 0 2 2 2 0 Annexin DDE_3 PF13358.1 KII66277.1 - 7.9e-05 22.4 0.1 9e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Flu_B_NS1 PF02942.9 KII66277.1 - 0.011 14.6 0.6 0.014 14.3 0.4 1.1 1 0 0 1 1 1 0 Influenza B non-structural protein (NS1) WIYLD PF10440.4 KII66281.1 - 0.053 13.4 0.0 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain HTH_10 PF04967.7 KII66285.1 - 0.011 15.3 0.1 0.019 14.5 0.1 1.4 1 0 0 1 1 1 0 HTH DNA binding domain Bot1p PF12298.3 KII66285.1 - 0.014 15.3 0.5 0.016 15.2 0.4 1.1 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein HTH_11 PF08279.7 KII66285.1 - 0.016 14.8 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 HTH domain GatB_Yqey PF02637.13 KII66285.1 - 0.077 12.7 0.1 0.089 12.5 0.1 1.1 1 0 0 1 1 1 0 GatB domain UPF0122 PF04297.9 KII66285.1 - 0.097 12.6 0.3 0.13 12.2 0.2 1.4 1 1 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_DeoR PF08220.7 KII66285.1 - 0.1 12.1 0.1 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain EGF_2 PF07974.8 KII66286.1 - 0.013 15.6 12.6 0.013 15.6 8.7 2.4 2 1 0 2 2 2 0 EGF-like domain hEGF PF12661.2 KII66286.1 - 1.8 8.7 5.3 7.1 6.9 3.7 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.8 KII66287.1 - 0.0057 16.7 13.4 0.0057 16.7 9.3 2.9 3 1 1 4 4 4 1 EGF-like domain hEGF PF12661.2 KII66287.1 - 1.2 9.4 13.6 0.37 10.9 3.1 3.7 3 0 0 3 3 3 0 Human growth factor-like EGF VEGF_C PF14554.1 KII66287.1 - 3.9 7.3 12.9 6.2 6.7 0.0 2.8 3 0 0 3 3 3 0 VEGF heparin-binding domain EGF_MSP1_1 PF12946.2 KII66287.1 - 6.8 6.5 13.6 3.1 7.6 6.1 2.7 1 1 2 3 3 3 0 MSP1 EGF domain 1 DUF3844 PF12955.2 KII66287.1 - 8 6.6 11.5 10 6.2 5.4 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3844) ABC_tran PF00005.22 KII66289.1 - 6.5e-46 156.0 0.2 6e-29 101.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 KII66289.1 - 1.2e-33 116.7 52.0 4.7e-17 62.3 14.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 KII66289.1 - 4.7e-09 35.7 0.4 0.00043 19.5 0.1 3.7 2 2 1 4 4 4 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 KII66289.1 - 1.5e-05 23.8 0.9 6.3e-05 21.7 0.1 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class T2SE PF00437.15 KII66289.1 - 8.5e-05 21.5 0.0 0.035 12.9 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein Miro PF08477.8 KII66289.1 - 0.00017 22.0 0.0 0.26 11.8 0.0 3.2 2 0 0 2 2 2 1 Miro-like protein AAA_23 PF13476.1 KII66289.1 - 0.00032 21.0 1.7 0.47 10.7 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KII66289.1 - 0.00046 20.2 0.0 1 9.2 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 KII66289.1 - 0.002 17.5 1.4 0.093 12.2 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain SH3_2 PF07653.12 KII66289.1 - 0.0023 17.3 0.0 0.013 14.9 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain AAA_25 PF13481.1 KII66289.1 - 0.0031 16.9 0.0 2.5 7.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 KII66289.1 - 0.0076 16.1 0.0 1.6 8.6 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KII66289.1 - 0.008 16.0 0.2 0.29 10.9 0.0 2.6 2 0 0 2 2 2 1 Dynamin family SH3_1 PF00018.23 KII66289.1 - 0.0086 15.4 0.0 0.02 14.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain AAA_22 PF13401.1 KII66289.1 - 0.0089 16.1 0.1 1.5 8.9 0.1 3.1 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 KII66289.1 - 0.024 14.1 0.5 4.1 6.8 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.4 KII66289.1 - 0.073 11.6 0.5 5.5 5.4 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.10 KII66289.1 - 0.11 12.1 0.7 0.31 10.7 0.0 2.1 2 0 0 2 2 2 0 NTPase Sigma54_activat PF00158.21 KII66289.1 - 0.12 11.8 0.0 2.1 7.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain MobB PF03205.9 KII66289.1 - 0.13 11.9 0.1 5.6 6.6 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ArgK PF03308.11 KII66289.1 - 0.29 9.8 0.0 0.53 9.0 0.0 1.3 1 0 0 1 1 1 0 ArgK protein DUF1754 PF08555.5 KII66290.1 - 0.017 15.7 16.5 0.3 11.7 11.4 2.0 1 1 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) DUF3074 PF11274.3 KII66290.1 - 0.12 12.0 0.7 0.13 11.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3074) RRM_1 PF00076.17 KII66292.1 - 5.8e-13 48.2 0.0 9.9e-13 47.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII66292.1 - 6.3e-11 42.0 0.0 9.7e-11 41.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII66292.1 - 2.1e-08 33.8 0.0 3.7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 KII66292.1 - 0.0051 17.2 0.2 0.0051 17.2 0.1 2.6 3 0 0 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 NeA_P2 PF12312.3 KII66292.1 - 0.095 11.9 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein DDE_Tnp_IS1595 PF12762.2 KII66294.1 - 6e-25 87.8 0.0 7.4e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF4371 PF14291.1 KII66295.1 - 0.14 11.7 4.8 0.54 9.7 3.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4371) rve PF00665.21 KII66297.1 - 1.3e-14 54.3 0.0 2e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII66297.1 - 0.00041 19.7 0.1 0.00069 19.0 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Nucleo_P87 PF07267.6 KII66297.1 - 0.022 13.5 0.1 0.022 13.4 0.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RVT_1 PF00078.22 KII66298.1 - 1.2e-08 34.6 0.0 3.1e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII66299.1 - 1.4e-07 31.3 0.0 2.9e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII66299.1 - 4.5e-05 23.8 0.0 9.4e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII66299.1 - 0.00014 21.4 0.0 0.00028 20.4 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVT_1 PF00078.22 KII66299.1 - 0.00024 20.5 0.0 0.00074 18.9 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A2B PF12384.3 KII66299.1 - 0.0033 16.7 1.6 0.072 12.4 0.1 2.9 2 1 1 3 3 3 1 Ty3 transposon peptidase Arf PF00025.16 KII66299.1 - 0.028 13.6 0.1 0.053 12.7 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF4326 PF14216.1 KII66305.1 - 0.1 13.2 0.3 2.4 8.7 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4326) Pentapeptide_4 PF13599.1 KII66309.1 - 0.013 15.2 0.5 0.022 14.5 0.3 1.4 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.1 KII66309.1 - 0.023 14.5 0.9 0.19 11.6 0.6 2.0 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) RVT_1 PF00078.22 KII66312.1 - 2.5e-06 27.0 0.0 0.037 13.3 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) BNR PF02012.15 KII66314.1 - 0.079 12.8 11.5 0.22 11.5 0.1 3.6 4 0 0 4 4 4 0 BNR/Asp-box repeat UCR_UQCRX_QCR9 PF05365.7 KII66314.1 - 0.08 12.5 0.5 11 5.7 0.1 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like RRM_1 PF00076.17 KII66315.1 - 1.8e-11 43.4 0.2 1.4e-10 40.5 0.1 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII66315.1 - 2.9e-08 33.4 0.1 6e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII66315.1 - 2.4e-07 30.6 0.1 4.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 KII66315.1 - 0.0003 20.3 1.2 0.0003 20.3 0.8 2.7 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nup35_RRM_2 PF14605.1 KII66315.1 - 0.00069 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif FYVE PF01363.16 KII66315.1 - 0.0036 17.1 1.9 0.005 16.7 0.2 2.0 2 0 0 2 2 2 1 FYVE zinc finger RRM_3 PF08777.6 KII66315.1 - 0.0061 16.3 0.1 0.038 13.8 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif PulG PF11773.3 KII66315.1 - 0.018 14.7 0.2 0.18 11.5 0.0 2.4 3 0 0 3 3 3 0 Type II secretory pathway pseudopilin zf-CCCH_2 PF14608.1 KII66315.1 - 0.053 13.5 1.1 0.053 13.5 0.8 2.2 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type Rad50_zn_hook PF04423.9 KII66315.1 - 0.17 11.3 0.0 0.17 11.3 0.0 2.1 3 0 0 3 3 3 0 Rad50 zinc hook motif OGG_N PF07934.7 KII66316.1 - 0.063 13.2 0.1 0.083 12.8 0.0 1.1 1 0 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain Integrin_beta PF00362.13 KII66317.1 - 0.00065 18.7 1.9 0.33 9.7 0.1 2.6 2 1 1 3 3 3 2 Integrin, beta chain EGF_2 PF07974.8 KII66317.1 - 0.0024 17.9 4.0 0.0024 17.9 2.8 2.7 2 1 0 2 2 2 1 EGF-like domain SNAP PF14938.1 KII66318.1 - 1.4e-10 40.7 0.8 2.1e-10 40.2 0.6 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII66318.1 - 0.011 15.6 1.6 0.029 14.2 0.3 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII66318.1 - 0.15 11.7 6.5 0.24 11.0 3.0 2.4 1 1 1 2 2 2 0 TPR repeat TPR_6 PF13174.1 KII66318.1 - 0.16 12.5 1.0 23 5.6 0.5 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII66318.1 - 0.24 11.4 3.3 1.5 8.9 1.6 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII66318.1 - 0.24 11.2 11.2 0.47 10.3 3.4 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII66318.1 - 6.2 6.6 7.7 23 4.7 3.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_C62 PF12380.3 KII66319.1 - 0.037 12.8 0.1 0.046 12.5 0.0 1.1 1 0 0 1 1 1 0 Gill-associated viral 3C-like peptidase Ocular_alb PF02101.10 KII66319.1 - 0.11 11.1 0.6 0.11 11.0 0.4 1.0 1 0 0 1 1 1 0 Ocular albinism type 1 protein DUF3884 PF13024.1 KII66320.1 - 7e-05 22.1 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3884) Cys_rich_CPXG PF14255.1 KII66320.1 - 0.068 12.9 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Cysteine-rich CPXCG Integrin_beta PF00362.13 KII66321.1 - 0.0024 16.8 0.0 0.0024 16.8 0.0 1.0 1 0 0 1 1 1 1 Integrin, beta chain DUF2209 PF09974.4 KII66321.1 - 0.044 13.8 0.1 0.057 13.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) SNAP PF14938.1 KII66322.1 - 9e-11 41.4 1.3 1.1e-10 41.1 0.9 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP KicB PF03882.9 KII66322.1 - 0.095 11.2 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 KicB killing factor PRESAN PF09687.5 KII66322.1 - 9.9 6.2 8.9 0.81 9.7 0.3 2.6 2 1 0 2 2 2 0 Plasmodium RESA N-terminal EGF_2 PF07974.8 KII66323.1 - 0.00039 20.5 15.1 0.0039 17.3 2.8 3.8 3 1 0 3 3 3 2 EGF-like domain DUF3469 PF11952.3 KII66323.1 - 0.0025 17.4 0.0 0.0055 16.3 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3469) Imm28 PF15574.1 KII66323.1 - 0.004 16.7 0.0 1.7 8.1 0.0 2.5 2 0 0 2 2 2 2 Immunity protein 28 DBP10CT PF08147.7 KII66323.1 - 0.18 11.6 1.0 5.1 6.9 0.1 2.9 3 0 0 3 3 3 0 DBP10CT (NUC160) domain Flg_new PF09479.5 KII66323.1 - 1.6 8.8 4.6 6.4 6.9 0.1 2.9 3 0 0 3 3 3 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) SNAP PF14938.1 KII66324.1 - 9e-07 28.3 2.7 1.1e-06 28.0 1.9 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP CtIP_N PF10482.4 KII66326.1 - 0.099 12.4 1.1 6.8 6.4 0.0 2.2 1 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain SNAP PF14938.1 KII66327.1 - 3.2e-11 42.9 2.6 4.3e-11 42.5 1.8 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SNAP PF14938.1 KII66328.1 - 2.4e-11 43.3 1.8 3.3e-11 42.8 1.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SCRG1 PF15224.1 KII66328.1 - 0.014 15.1 0.4 0.033 13.9 0.1 1.9 2 0 0 2 2 2 0 Scrapie-responsive protein 1 NSF PF02071.15 KII66328.1 - 0.39 11.4 3.8 48 5.2 0.2 4.4 4 1 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat PLAC8 PF04749.12 KII66329.1 - 1.6e-15 57.5 14.8 1.9e-15 57.2 10.3 1.1 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.12 KII66330.1 - 3.6e-19 69.2 16.9 4.1e-19 69.0 11.7 1.0 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.12 KII66331.1 - 1.3e-19 70.6 7.7 1.5e-19 70.4 5.4 1.1 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.12 KII66332.1 - 6.8e-19 68.3 18.0 7.8e-19 68.1 12.4 1.0 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.12 KII66333.1 - 7.1e-19 68.3 16.9 8.3e-19 68.1 11.7 1.1 1 0 0 1 1 1 1 PLAC8 family Thioredoxin PF00085.15 KII66333.1 - 2.5 7.8 5.1 6.1 6.5 0.1 2.1 2 0 0 2 2 2 0 Thioredoxin PLAC8 PF04749.12 KII66334.1 - 3.5e-14 53.2 11.6 5.4e-14 52.6 8.1 1.3 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.12 KII66335.1 - 3.8e-10 40.2 10.6 5e-10 39.8 7.4 1.2 1 0 0 1 1 1 1 PLAC8 family Pro-rich PF15240.1 KII66335.1 - 7.4 6.6 31.6 9.6 6.2 21.9 1.0 1 0 0 1 1 1 0 Proline-rich PLAC8 PF04749.12 KII66337.1 - 5.2e-07 30.1 3.4 7.9e-07 29.6 2.4 1.3 1 0 0 1 1 1 1 PLAC8 family Rep_N PF08724.5 KII66338.1 - 0.0027 17.2 0.0 0.0032 17.0 0.0 1.1 1 0 0 1 1 1 1 Rep protein catalytic domain like PLAC8 PF04749.12 KII66340.1 - 6.1e-17 62.1 19.3 7.2e-17 61.8 13.4 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4218 PF13960.1 KII66340.1 - 0.12 11.8 0.1 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) PLAC8 PF04749.12 KII66343.1 - 9.8e-18 64.6 15.6 1.2e-17 64.3 10.8 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4218 PF13960.1 KII66343.1 - 0.011 15.2 1.0 0.057 12.8 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4218) WD40 PF00400.27 KII66345.1 - 5.9e-15 54.4 5.3 1.6e-05 24.5 0.1 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KII66345.1 - 0.012 14.3 0.3 2.7 6.6 0.0 2.0 1 1 1 2 2 2 0 Nup133 N terminal like BBS2_Mid PF14783.1 KII66345.1 - 0.031 14.0 0.0 0.048 13.4 0.0 1.5 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.3 KII66345.1 - 0.22 9.6 2.1 1.9 6.5 1.4 2.4 1 1 0 1 1 1 0 Nucleoporin Nup120/160 WD40 PF00400.27 KII66346.1 - 1.5e-23 81.7 24.8 1.5e-05 24.6 0.0 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 KII66346.1 - 0.0078 14.5 0.3 0.57 8.4 0.0 2.7 1 1 2 3 3 3 2 Cytochrome D1 heme domain VHS PF00790.14 KII66347.1 - 2.2e-07 30.6 0.0 2.5e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 VHS domain ENTH PF01417.15 KII66347.1 - 0.05 13.4 0.0 0.058 13.2 0.0 1.2 1 0 0 1 1 1 0 ENTH domain WD40 PF00400.27 KII66348.1 - 1.9e-22 78.2 27.7 1.6e-07 30.8 0.0 6.3 7 0 0 7 7 7 5 WD domain, G-beta repeat DUF3312 PF11768.3 KII66348.1 - 0.029 12.5 0.0 0.057 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) Glyco_transf_8 PF01501.15 KII66348.1 - 0.097 11.9 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 8 DDE_3 PF13358.1 KII66349.1 - 7e-26 90.7 0.1 2.9e-25 88.7 0.0 1.8 1 1 1 2 2 2 1 DDE superfamily endonuclease rve PF00665.21 KII66349.1 - 0.14 12.2 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain PAX PF00292.13 KII66350.1 - 0.0001 22.0 0.1 0.00013 21.6 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.1 KII66350.1 - 0.00089 19.3 0.0 0.0014 18.7 0.0 1.3 1 1 0 1 1 1 1 Winged helix-turn helix HTH_24 PF13412.1 KII66350.1 - 0.0016 17.8 0.2 0.074 12.4 0.1 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Sigma70_r4_2 PF08281.7 KII66350.1 - 0.0043 16.4 0.0 0.0086 15.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.1 KII66350.1 - 0.0075 15.8 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_8 PF02954.14 KII66350.1 - 0.0098 15.4 0.4 0.05 13.1 0.0 2.3 3 0 0 3 3 3 1 Bacterial regulatory protein, Fis family TrmB PF01978.14 KII66350.1 - 0.019 14.6 0.0 0.039 13.6 0.0 1.6 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_38 PF13936.1 KII66350.1 - 0.022 14.2 0.1 0.51 9.9 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Homeobox_KN PF05920.6 KII66352.1 - 1.3e-15 56.7 0.6 3.6e-15 55.3 0.2 1.9 2 0 0 2 2 2 1 Homeobox KN domain Homeobox PF00046.24 KII66352.1 - 3.8e-07 29.6 0.1 9.1e-07 28.4 0.1 1.6 1 0 0 1 1 1 1 Homeobox domain WASH-7_N PF14745.1 KII66352.1 - 0.079 11.1 0.1 0.14 10.3 0.0 1.4 2 0 0 2 2 2 0 WASH complex subunit 7, N-terminal DotA PF11388.3 KII66352.1 - 0.093 12.7 0.2 0.25 11.3 0.1 1.7 1 1 0 2 2 2 0 Phagosome trafficking protein DotA HA PF03457.9 KII66352.1 - 0.12 12.5 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Helicase associated domain DUF3728 PF12528.3 KII66352.1 - 0.2 12.0 2.2 0.36 11.2 0.2 2.0 2 0 0 2 2 2 0 Prepilin peptidase dependent protein C (DUF3728) SIR2 PF02146.12 KII66353.1 - 1e-33 116.5 0.0 1.7e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 Sir2 family zinc_ribbon_2 PF13240.1 KII66353.1 - 0.1 12.1 1.5 3.6 7.2 0.0 2.5 2 1 0 2 2 2 0 zinc-ribbon domain NinF PF05810.7 KII66353.1 - 1.2 8.9 4.2 0.83 9.5 0.7 2.4 2 1 1 3 3 3 0 NinF protein DUF3716 PF12511.3 KII66353.1 - 4.5 6.9 5.9 17 5.1 4.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3716) zf-ribbon_3 PF13248.1 KII66353.1 - 9.7 5.5 9.7 6.3 6.1 3.4 2.8 2 1 1 3 3 3 0 zinc-ribbon domain Pro_isomerase PF00160.16 KII66354.1 - 1.2e-43 149.0 0.0 2.2e-43 148.1 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.7 KII66354.1 - 3.7e-09 36.1 0.2 3.7e-09 36.1 0.1 2.2 2 0 0 2 2 2 1 Rtf2 RING-finger CTDII PF01556.13 KII66356.1 - 8.4e-16 57.6 0.0 1.9e-15 56.4 0.0 1.6 2 0 0 2 2 2 1 DnaJ C terminal domain HpcH_HpaI PF03328.9 KII66358.1 - 2.5e-24 85.4 0.0 3.3e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 KII66358.1 - 0.014 14.2 0.1 0.1 11.3 0.0 2.0 2 1 0 2 2 2 0 C-C_Bond_Lyase of the TIM-Barrel fold FLYWCH PF04500.11 KII66360.1 - 0.016 15.0 1.6 0.03 14.2 1.1 1.4 1 0 0 1 1 1 0 FLYWCH zinc finger domain Zn_ribbon_recom PF13408.1 KII66360.1 - 1.2 9.4 4.9 2.1 8.6 3.4 1.6 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain Thoc2 PF11732.3 KII66361.1 - 0.027 14.2 0.0 0.057 13.2 0.0 1.6 1 0 0 1 1 1 0 Transcription- and export-related complex subunit Serpin PF00079.15 KII66362.1 - 8.2e-20 71.2 2.6 1e-19 70.9 1.8 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII66363.1 - 8.6e-13 48.1 0.2 8.9e-13 48.1 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Imm23 PF15593.1 KII66363.1 - 0.0072 16.5 0.1 0.0088 16.2 0.1 1.1 1 0 0 1 1 1 1 Immunity protein 23 Pox_A31 PF05771.6 KII66363.1 - 0.14 11.9 0.4 0.26 11.1 0.3 1.5 1 1 0 1 1 1 0 Poxvirus A31 protein Chromadorea_ALT PF05535.7 KII66363.1 - 0.15 12.1 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Chromadorea ALT protein Serpin PF00079.15 KII66364.1 - 3.1e-20 72.6 0.3 3.3e-20 72.5 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF2333 PF10095.4 KII66364.1 - 0.022 13.4 0.0 0.03 12.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) Serpin PF00079.15 KII66365.1 - 9.1e-27 94.1 0.5 1e-26 93.9 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) BK_channel_a PF03493.13 KII66365.1 - 0.093 12.6 0.4 0.29 11.0 0.3 1.8 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit SNAP PF14938.1 KII66366.1 - 2e-12 46.8 3.4 2.4e-12 46.5 2.4 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII66366.1 - 8.5e-06 25.6 3.2 0.004 17.0 0.7 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII66366.1 - 0.0086 15.9 11.5 0.67 10.0 0.7 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat CtIP_N PF10482.4 KII66366.1 - 0.032 14.0 1.4 5 6.9 0.1 2.3 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain FbpA PF05833.6 KII66366.1 - 0.035 12.6 0.4 0.046 12.2 0.3 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Rapamycin_bind PF08771.6 KII66366.1 - 0.042 13.9 1.5 1.6 8.8 0.0 2.6 1 1 2 3 3 3 0 Rapamycin binding domain TPR_6 PF13174.1 KII66366.1 - 0.053 14.0 3.0 10 6.8 0.2 4.0 3 1 0 4 4 4 0 Tetratricopeptide repeat DUF3887 PF13026.1 KII66366.1 - 0.12 12.6 2.9 0.14 12.4 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3887) NSF PF02071.15 KII66366.1 - 0.13 12.8 4.0 39 5.4 0.0 4.3 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat PA28_beta PF02252.13 KII66366.1 - 0.16 11.4 3.2 0.31 10.5 0.7 2.0 1 1 1 2 2 2 0 Proteasome activator pa28 beta subunit TPR_7 PF13176.1 KII66366.1 - 1 9.3 4.8 18 5.4 0.1 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII66366.1 - 3.2 7.7 10.5 32 4.6 0.2 4.9 5 1 1 6 6 6 0 Tetratricopeptide repeat AAA_22 PF13401.1 KII66367.1 - 6.2e-05 23.1 0.0 0.00037 20.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KII66367.1 - 0.00013 22.0 2.6 0.076 13.2 0.0 3.3 3 0 0 3 3 3 2 RNA helicase AAA PF00004.24 KII66367.1 - 0.0033 17.6 0.0 0.0097 16.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KII66367.1 - 0.0082 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain DUF3856 PF12968.2 KII66367.1 - 0.046 13.5 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) AAA_5 PF07728.9 KII66367.1 - 0.078 12.7 0.0 2.1 8.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) TLD PF07534.11 KII66368.1 - 3.9e-31 107.8 2.6 6.5e-31 107.1 1.1 1.8 2 0 0 2 2 2 1 TLD DUF1192 PF06698.6 KII66370.1 - 0.0048 16.6 0.1 0.013 15.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) DUF4407 PF14362.1 KII66370.1 - 0.0072 15.3 2.8 0.0097 14.8 1.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Prp19 PF08606.6 KII66370.1 - 0.022 14.4 0.4 4.5 7.0 0.0 2.8 1 1 1 2 2 2 0 Prp19/Pso4-like THOC7 PF05615.8 KII66370.1 - 0.042 14.1 1.3 0.042 14.1 0.9 2.5 1 1 2 3 3 3 0 Tho complex subunit 7 AKNA PF12443.3 KII66370.1 - 0.054 13.5 6.8 0.37 10.8 0.3 2.5 1 1 0 2 2 2 0 AT-hook-containing transcription factor Lzipper-MIP1 PF14389.1 KII66370.1 - 0.058 13.4 2.8 0.096 12.8 1.4 1.8 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Kinetocho_Slk19 PF12709.2 KII66370.1 - 0.072 13.1 0.4 0.072 13.1 0.3 2.6 2 1 0 2 2 2 0 Central kinetochore-associated DUF4200 PF13863.1 KII66370.1 - 0.22 11.4 9.3 1.2 9.0 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF904 PF06005.7 KII66370.1 - 0.32 11.3 14.1 3.6 7.9 2.4 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF4140 PF13600.1 KII66370.1 - 0.8 10.1 3.5 0.31 11.5 0.2 1.9 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Cep57_CLD_2 PF14197.1 KII66370.1 - 0.92 9.4 7.8 7.8 6.5 0.8 2.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Spectrin PF00435.16 KII66370.1 - 0.94 9.7 7.1 1.9 8.8 3.2 2.3 1 1 1 2 2 2 0 Spectrin repeat Allexi_40kDa PF05549.6 KII66370.1 - 0.97 8.6 7.4 3.6 6.7 0.5 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein Sec2p PF06428.6 KII66370.1 - 1 9.2 8.8 1.7 8.5 5.3 2.0 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p DivIC PF04977.10 KII66370.1 - 1.1 8.7 7.8 0.29 10.6 0.3 2.8 2 1 0 2 2 2 0 Septum formation initiator TPR_MLP1_2 PF07926.7 KII66370.1 - 2.4 7.9 13.9 2.3 7.9 0.8 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Cep57_MT_bd PF06657.8 KII66370.1 - 6.1 6.8 10.9 16 5.5 3.1 2.5 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 HALZ PF02183.13 KII66370.1 - 6.4 6.5 13.2 7.7 6.3 0.5 4.0 4 1 0 4 4 4 0 Homeobox associated leucine zipper Seryl_tRNA_N PF02403.17 KII66370.1 - 9.4 6.2 14.8 0.93 9.5 0.7 2.8 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain rve PF00665.21 KII66374.1 - 7.8e-21 74.4 0.1 1.9e-20 73.1 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII66374.1 - 5.3e-15 55.3 0.0 1.5e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.18 KII66374.1 - 0.00013 21.7 12.3 0.075 12.9 4.2 2.7 2 0 0 2 2 2 2 Zinc knuckle rve_3 PF13683.1 KII66374.1 - 0.00025 20.5 0.0 0.00065 19.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII66374.1 - 0.00079 19.1 0.1 0.0021 17.8 0.1 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease RVP PF00077.15 KII66374.1 - 0.054 13.4 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease Nepo_coat_N PF03689.10 KII66374.1 - 0.11 12.2 0.1 0.51 10.1 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Asp_protease_2 PF13650.1 KII66374.1 - 0.11 12.9 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.1 KII66374.1 - 0.5 10.0 6.5 7.4 6.3 0.5 2.9 2 0 0 2 2 2 0 Zinc knuckle Tmemb_9 PF05434.6 KII66376.1 - 0.098 12.4 1.0 0.48 10.1 0.0 2.3 2 0 0 2 2 2 0 TMEM9 IU_nuc_hydro PF01156.14 KII66377.1 - 2.2e-45 155.2 0.0 2.5e-45 155.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase BNR PF02012.15 KII66378.1 - 4.8e-05 22.5 3.3 3.6 7.8 0.0 3.6 3 0 0 3 3 3 3 BNR/Asp-box repeat Serpin PF00079.15 KII66379.1 - 1.3e-40 139.6 1.6 1.5e-40 139.5 1.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ldl_recept_a PF00057.13 KII66382.1 - 6.1e-11 42.0 23.2 7.4e-07 28.9 3.8 2.9 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII66382.1 - 9.7 5.7 17.3 17 4.9 12.0 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Ldl_recept_a PF00057.13 KII66383.1 - 4.8e-16 58.3 49.2 1.2e-07 31.4 7.0 3.7 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A Cauli_DNA-bind PF03310.8 KII66383.1 - 0.36 10.6 2.1 0.27 11.0 0.3 1.8 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein YARHG PF13308.1 KII66389.1 - 0.032 13.7 0.2 0.083 12.4 0.2 1.9 1 1 0 1 1 1 0 YARHG domain DUF458 PF04308.7 KII66389.1 - 0.042 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF458) Pox_H7 PF04787.7 KII66389.1 - 0.11 12.3 4.2 2.6 7.8 0.4 2.3 1 1 1 2 2 2 0 Late protein H7 Sial-lect-inser PF09264.5 KII66391.1 - 0.018 14.4 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Vibrio cholerae sialidase, lectin insertion RVT_1 PF00078.22 KII66394.1 - 2.2e-09 36.9 0.2 4.2e-09 36.0 0.1 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4448 PF14610.1 KII66399.1 - 0.0015 18.0 0.6 0.0019 17.7 0.3 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) TMEM154 PF15102.1 KII66399.1 - 0.0016 18.1 2.1 0.0019 17.8 1.4 1.4 1 1 0 1 1 1 1 TMEM154 protein family Herpes_gE PF02480.11 KII66399.1 - 0.0017 16.6 0.2 0.0021 16.3 0.1 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.1 KII66399.1 - 0.0024 18.2 2.8 0.011 16.0 1.6 2.0 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain DUF1191 PF06697.7 KII66399.1 - 0.0027 16.5 0.6 0.0038 16.0 0.4 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1191) DUF912 PF06024.7 KII66399.1 - 0.03 14.3 0.3 0.045 13.7 0.1 1.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Orthoreo_P10 PF07204.6 KII66399.1 - 0.053 13.2 0.8 0.25 11.1 0.8 1.8 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 Ribosomal_L18ae PF01775.12 KII66399.1 - 0.077 12.8 0.0 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 Ribosomal L18ae/LX protein domain gpUL132 PF11359.3 KII66399.1 - 0.079 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycoprotein UL132 DUF1129 PF06570.6 KII66399.1 - 0.091 12.0 0.2 0.17 11.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) CD34_antigen PF06365.7 KII66399.1 - 0.11 12.1 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family STE2 PF02116.10 KII66399.1 - 0.12 11.3 1.2 0.12 11.3 0.2 1.5 2 0 0 2 2 2 0 Fungal pheromone mating factor STE2 GPCR TMEM51 PF15345.1 KII66399.1 - 0.21 11.2 1.7 0.29 10.8 0.9 1.5 1 1 0 1 1 1 0 Transmembrane protein 51 DUF4064 PF13273.1 KII66399.1 - 0.72 9.9 4.2 2.6 8.1 2.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) Shisa PF13908.1 KII66399.1 - 2.9 8.0 10.0 2 8.5 5.3 1.8 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator A_deaminase PF00962.17 KII66400.1 - 0.063 12.1 0.1 0.095 11.5 0.0 1.2 1 0 0 1 1 1 0 Adenosine/AMP deaminase EF-hand_4 PF12763.2 KII66403.1 - 8.3e-12 44.7 0.1 2.1e-11 43.4 0.0 1.7 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 KII66403.1 - 0.0025 17.0 0.1 0.006 15.8 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KII66403.1 - 0.061 12.9 0.5 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair Homeobox PF00046.24 KII66404.1 - 1.2e-09 37.6 1.7 2.3e-09 36.7 1.2 1.5 1 0 0 1 1 1 1 Homeobox domain Thiolase_N PF00108.18 KII66405.1 - 1e-80 270.5 0.2 1.4e-80 270.1 0.1 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 KII66405.1 - 2.6e-41 139.9 0.7 2.6e-41 139.9 0.5 1.9 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 KII66405.1 - 5.9e-06 25.9 1.3 2.5e-05 23.9 0.6 1.9 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 KII66405.1 - 7.5 6.2 6.8 18 5.0 0.0 2.7 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III IFNGR1 PF07140.6 KII66407.1 - 0.061 13.0 1.4 0.12 12.1 0.3 2.0 1 1 2 3 3 3 0 Interferon gamma receptor (IFNGR1) Nucleic_acid_bd PF13820.1 KII66407.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative nucleic acid-binding region TMEM154 PF15102.1 KII66409.1 - 0.05 13.2 1.6 0.12 12.1 1.2 1.5 1 1 0 1 1 1 0 TMEM154 protein family EGF PF00008.22 KII66411.1 - 1.2e-05 25.1 4.1 1.2e-05 25.1 2.9 4.6 3 1 0 4 4 4 1 EGF-like domain Sina PF03145.11 KII66411.1 - 0.024 14.2 7.4 0.048 13.3 5.1 1.4 1 0 0 1 1 1 0 Seven in absentia protein family IL4Ra_N PF09238.5 KII66411.1 - 1.3 9.1 14.7 0.034 14.2 5.5 1.7 1 1 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal Tme5_EGF_like PF09064.5 KII66411.1 - 9.1 5.9 22.1 5.5 6.6 0.2 4.1 3 1 0 3 3 3 0 Thrombomodulin like fifth domain, EGF-like CUB PF00431.15 KII66412.1 - 0.033 14.2 0.7 0.033 14.2 0.5 1.9 2 1 0 2 2 2 0 CUB domain SNF2_N PF00176.18 KII66413.1 - 4.6e-28 97.8 0.2 5.3e-28 97.6 0.1 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 KII66413.1 - 4.1e-05 23.1 0.0 4.4e-05 23.0 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KII66413.1 - 0.013 15.3 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit GMP_synt_C PF00958.17 KII66413.1 - 0.022 14.4 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 GMP synthase C terminal domain AAA_34 PF13872.1 KII66413.1 - 0.099 11.3 0.0 0.11 11.2 0.0 1.0 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 SNF2_N PF00176.18 KII66414.1 - 1.2e-07 30.8 0.3 1.5e-07 30.5 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3895 PF13034.1 KII66417.1 - 0.074 12.5 2.5 0.22 11.0 1.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3895) HECT PF00632.20 KII66418.1 - 2.3e-67 227.3 0.3 2.6e-67 227.2 0.2 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.20 KII66419.1 - 0.019 14.1 0.0 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain RNB PF00773.14 KII66423.1 - 9.1e-82 274.9 0.7 1.3e-81 274.4 0.5 1.2 1 0 0 1 1 1 1 RNB domain DUF421 PF04239.7 KII66424.1 - 0.025 14.0 0.7 0.045 13.2 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF421) FimP PF09766.4 KII66424.1 - 0.051 12.6 2.4 0.073 12.1 1.6 1.2 1 0 0 1 1 1 0 Fms-interacting protein Med4 PF10018.4 KII66424.1 - 0.28 10.5 1.7 0.55 9.6 0.2 2.0 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DDE_Tnp_IS1595 PF12762.2 KII66425.1 - 1.6e-13 50.7 0.0 2.7e-13 50.0 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain HTH_23 PF13384.1 KII66425.1 - 1e-06 28.1 0.0 2e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.1 KII66425.1 - 0.00032 20.1 2.4 0.00035 20.0 0.3 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.1 KII66425.1 - 0.0096 15.9 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.17 KII66425.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix Sigma70_r4 PF04545.11 KII66425.1 - 0.02 14.2 0.1 0.039 13.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.1 KII66425.1 - 0.037 13.1 0.3 0.063 12.4 0.2 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_37 PF13744.1 KII66425.1 - 0.042 13.6 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.8 KII66425.1 - 0.087 12.2 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain TrmB PF01978.14 KII66425.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB RRS1 PF04939.7 KII66426.1 - 1.3e-32 112.5 5.0 2e-32 111.9 3.4 1.2 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DNA_pol_alpha_N PF12254.3 KII66426.1 - 0.24 11.2 4.7 0.17 11.7 1.4 2.1 1 1 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal NUDIX PF00293.23 KII66427.1 - 1.4e-19 70.0 0.0 6.6e-19 67.8 0.0 1.8 2 0 0 2 2 2 1 NUDIX domain Toxin_8 PF07365.7 KII66427.1 - 0.058 13.3 0.5 0.12 12.3 0.3 1.4 1 0 0 1 1 1 0 Alpha conotoxin precursor DUF1860 PF08949.5 KII66428.1 - 0.13 11.8 3.2 0.15 11.6 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1860) DDE_Tnp_IS1595 PF12762.2 KII66429.1 - 3.2e-17 62.7 0.0 5.5e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_ribbon_recom PF13408.1 KII66429.1 - 0.063 13.5 2.0 0.15 12.3 0.9 1.9 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-CHY PF05495.7 KII66429.1 - 0.093 12.8 1.6 0.18 11.9 1.1 1.4 1 0 0 1 1 1 0 CHY zinc finger Gin PF10764.4 KII66429.1 - 0.11 12.2 1.6 0.86 9.3 0.1 2.4 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin Gal-3-0_sulfotr PF06990.6 KII66434.1 - 3.9e-17 62.0 7.0 9.9e-16 57.3 4.9 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase FG-GAP PF01839.18 KII66438.1 - 8.5e-09 34.8 4.1 0.00077 19.0 1.6 2.5 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.1 KII66438.1 - 5.5e-07 29.8 4.1 2.3e-06 27.8 1.1 3.0 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Spc7_C2 PF15577.1 KII66439.1 - 0.091 12.4 0.0 16 5.1 0.0 2.2 2 0 0 2 2 2 0 Spc7_C2 Astacin PF01400.19 KII66439.1 - 0.11 11.9 0.4 0.16 11.3 0.1 1.4 1 1 0 1 1 1 0 Astacin (Peptidase family M12A) SNAP PF14938.1 KII66442.1 - 3.3e-07 29.7 8.9 5.1e-06 25.8 6.1 2.2 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII66442.1 - 0.32 10.6 5.6 0.18 11.5 1.4 2.3 2 0 0 2 2 2 0 TPR repeat TPR_12 PF13424.1 KII66442.1 - 0.61 10.0 6.0 1.7 8.6 2.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 KII66442.1 - 0.66 10.5 3.2 0.72 10.4 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-DHHC PF01529.15 KII66445.1 - 6.2 6.1 8.8 0.61 9.4 2.8 1.7 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF3796 PF12676.2 KII66448.1 - 0.1 12.8 1.6 0.14 12.4 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3796) rve PF00665.21 KII66450.1 - 4.9e-23 81.5 0.0 1e-22 80.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII66450.1 - 0.0077 15.7 0.0 0.021 14.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain SET PF00856.23 KII66453.1 - 2.7e-26 92.7 1.2 2.7e-26 92.7 0.8 5.1 5 2 0 5 5 5 2 SET domain DER1 PF04511.10 KII66454.1 - 2.5e-22 79.3 4.8 3e-22 79.0 3.3 1.1 1 0 0 1 1 1 1 Der1-like family DUF1368 PF07112.6 KII66457.1 - 0.013 14.0 0.2 0.014 13.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1368) TetR_C_9 PF14514.1 KII66457.1 - 0.033 13.9 0.0 0.05 13.4 0.0 1.3 1 1 0 1 1 1 0 Transcriptional regulator, TetR, C-terminal PRELI PF04707.9 KII66459.1 - 9.7e-23 80.4 0.1 1.5e-22 79.8 0.1 1.3 1 0 0 1 1 1 1 PRELI-like family RCR PF12273.3 KII66460.1 - 0.0024 18.4 0.5 0.0029 18.1 0.3 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red 7tm_1 PF00001.16 KII66460.1 - 0.044 12.9 2.4 0.053 12.6 1.7 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) RCR PF12273.3 KII66461.1 - 0.02 15.4 1.1 0.023 15.2 0.8 1.2 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red DUF2668 PF10873.3 KII66461.1 - 0.35 11.0 3.9 0.39 10.8 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2668) DUF2873 PF11395.3 KII66461.1 - 2.3 7.8 8.3 3.7 7.2 5.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2873) Acyl-CoA_dh_1 PF00441.19 KII66462.1 - 6.1e-26 91.3 0.1 3.8e-13 49.7 0.0 2.2 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.6 KII66462.1 - 7.2e-05 23.0 0.0 0.00057 20.1 0.0 2.0 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain WD40 PF00400.27 KII66466.1 - 2.1e-12 46.3 13.0 2e-06 27.4 0.2 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat BCDHK_Adom3 PF10436.4 KII66466.1 - 0.13 11.8 3.1 2.4 7.6 0.2 2.5 2 0 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase WD40 PF00400.27 KII66467.1 - 2.1e-48 160.5 8.6 1.5e-08 34.2 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat eIF2A PF08662.6 KII66467.1 - 1.3e-07 31.5 0.0 0.0018 18.0 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KII66467.1 - 0.0015 16.7 1.4 1.6 6.7 0.3 2.9 1 1 1 2 2 2 2 Nucleoporin Nup120/160 zf-UBR PF02207.15 KII66471.1 - 4.5e-11 42.2 8.0 4.5e-11 42.2 5.6 1.9 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Claudin_2 PF13903.1 KII66472.1 - 1.4e-05 24.8 12.2 1.4e-05 24.8 8.5 1.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PIRT PF15099.1 KII66472.1 - 3.8 6.7 9.7 0.84 8.8 2.2 2.4 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family O-FucT PF10250.4 KII66475.1 - 0.02 14.0 1.9 0.028 13.5 1.3 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Hat1_N PF10394.4 KII66481.1 - 0.033 14.2 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 Histone acetyl transferase HAT1 N-terminus Rft-1 PF04506.8 KII66483.1 - 4e-35 121.1 31.7 8.1e-28 97.0 17.5 2.1 1 1 1 2 2 2 2 Rft protein OST-HTH PF12872.2 KII66484.1 - 5.9e-09 35.6 0.2 7.2e-06 25.7 0.0 2.8 4 0 0 4 4 4 2 OST-HTH/LOTUS domain TUDOR PF00567.19 KII66485.1 - 0.0033 17.2 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 Tudor domain LRR19-TM PF15176.1 KII66487.1 - 0.064 12.9 0.2 0.064 12.9 0.2 2.4 2 1 1 3 3 3 0 Leucine-rich repeat family 19 TM domain SUR7 PF06687.7 KII66487.1 - 2.2 7.7 16.9 1.2e+02 2.1 11.7 2.2 1 1 0 1 1 1 0 SUR7/PalI family Peptidase_C10 PF01640.12 KII66492.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Peptidase C10 family RVP PF00077.15 KII66493.1 - 1.5e-05 24.8 0.0 3.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII66493.1 - 0.091 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Rep_fac-A_C PF08646.5 KII66495.1 - 2.9e-22 78.9 3.9 1.7e-19 69.9 0.8 2.8 2 1 1 3 3 3 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 KII66495.1 - 3.3e-05 23.6 0.3 0.00092 19.0 0.0 2.8 2 1 1 3 3 3 1 OB-fold nucleic acid binding domain DUF223 PF02721.9 KII66495.1 - 0.028 14.4 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF223 Zn-ribbon_8 PF09723.5 KII66495.1 - 0.3 11.0 2.7 0.32 10.9 0.3 2.1 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_2 PF13465.1 KII66495.1 - 1.2 9.6 7.5 0.3 11.4 2.6 2.0 2 0 0 2 2 2 0 Zinc-finger double domain DUF3350 PF11830.3 KII66497.1 - 0.1 12.6 0.2 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3350) Rep_fac-A_C PF08646.5 KII66498.1 - 1.6e-28 99.2 4.9 9.5e-26 90.2 0.6 3.0 3 0 0 3 3 3 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 KII66498.1 - 3.5e-05 23.5 0.1 0.01 15.6 0.0 2.6 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain CotH PF08757.6 KII66501.1 - 0.061 12.5 0.0 0.073 12.3 0.0 1.1 1 0 0 1 1 1 0 CotH protein PepSY_TM_2 PF13703.1 KII66504.1 - 0.0032 17.6 0.0 0.022 14.9 0.0 2.1 2 0 0 2 2 2 1 PepSY-associated TM helix CD34_antigen PF06365.7 KII66504.1 - 0.0086 15.7 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 1 CD34/Podocalyxin family Hox9_act PF04617.8 KII66504.1 - 0.066 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Hox9 activation region DUF912 PF06024.7 KII66504.1 - 0.079 13.0 0.2 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ASFV_J13L PF05568.6 KII66504.1 - 0.13 11.7 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein ADK_lid PF05191.9 KII66504.1 - 4.4 7.0 7.1 18 5.0 0.0 3.3 3 0 0 3 3 3 0 Adenylate kinase, active site lid Integrin_beta PF00362.13 KII66505.1 - 4.8e-38 131.1 3.5 3.7e-23 82.1 1.1 2.2 2 0 0 2 2 2 2 Integrin, beta chain DUF4371 PF14291.1 KII66506.1 - 0.0075 15.8 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) YsaB PF13983.1 KII66508.1 - 0.084 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 YsaB-like lipoprotein Keratin_B2_2 PF13885.1 KII66510.1 - 8.1e-28 95.8 136.9 0.00054 19.6 11.4 7.4 1 1 6 7 7 7 6 Keratin, high sulfur B2 protein PMG PF05287.7 KII66510.1 - 0.36 10.6 131.5 1.9 8.2 38.8 3.1 1 1 2 3 3 3 0 PMG protein Hexokinase_2 PF03727.11 KII66511.1 - 1.2e-59 201.4 0.0 1.5e-59 201.1 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII66511.1 - 1.5e-23 83.2 0.0 2.3e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Hexokinase DUF2012 PF09430.5 KII66512.1 - 0.13 12.0 1.3 0.29 10.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) RVT_1 PF00078.22 KII66515.1 - 6.8e-06 25.5 0.2 5.2e-05 22.7 0.1 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Toxin_10 PF05431.6 KII66516.1 - 0.005 16.4 0.3 0.27 10.8 0.1 2.1 2 0 0 2 2 2 2 Insecticidal Crystal Toxin, P42 Hexokinase_2 PF03727.11 KII66518.1 - 2.3e-59 200.5 0.0 2.9e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII66518.1 - 5.8e-24 84.5 0.0 9.4e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Hexokinase EVI2A PF05399.6 KII66520.1 - 0.03 13.5 6.6 0.043 13.0 4.6 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DUF370 PF04025.7 KII66520.1 - 0.17 11.9 2.4 0.27 11.3 0.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF370) AJAP1_PANP_C PF15298.1 KII66520.1 - 0.26 11.1 12.2 0.31 10.8 8.4 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus RVT_1 PF00078.22 KII66521.1 - 2.5e-18 66.2 0.0 6.9e-18 64.7 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII66521.1 - 0.0035 17.2 0.0 0.011 15.6 0.0 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII66521.1 - 0.075 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease SapA PF02199.10 KII66523.1 - 0.086 12.6 0.2 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Saposin A-type domain HTH_Tnp_Tc3_2 PF01498.13 KII66527.1 - 0.097 12.7 0.1 0.22 11.6 0.0 1.5 1 1 0 1 1 1 0 Transposase IlvC PF01450.14 KII66527.1 - 0.12 12.3 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain DDE_Tnp_IS1595 PF12762.2 KII66528.1 - 5.8e-07 29.4 0.0 1.8e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain WRC PF08879.5 KII66528.1 - 0.014 15.0 1.6 0.036 13.7 1.1 1.7 1 0 0 1 1 1 0 WRC Ribosomal_S4e PF00900.15 KII66529.1 - 8.6e-29 99.0 0.3 8.6e-29 99.0 0.2 1.8 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.7 KII66529.1 - 9.1e-20 70.2 4.4 7.3e-19 67.3 3.5 2.1 2 0 0 2 2 2 1 RS4NT (NUC023) domain KOW PF00467.24 KII66529.1 - 1.3e-05 24.6 0.4 1.3e-05 24.6 0.2 2.7 2 0 0 2 2 2 1 KOW motif S4 PF01479.20 KII66529.1 - 5.1e-05 22.6 0.2 0.00015 21.0 0.0 1.9 2 0 0 2 2 2 1 S4 domain Phage_attach PF05354.6 KII66529.1 - 0.099 12.1 0.1 6 6.4 0.0 2.2 2 0 0 2 2 2 0 Phage Head-Tail Attachment RRM_1 PF00076.17 KII66532.1 - 2.5e-13 49.4 0.0 4.2e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII66532.1 - 4e-10 39.5 0.0 7.5e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII66532.1 - 1.8e-06 27.6 0.0 3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 KII66532.1 - 5e-05 23.6 1.4 5e-05 23.6 1.0 2.5 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 V-ATPase_G PF03179.10 KII66532.1 - 0.11 12.8 0.3 0.3 11.4 0.2 1.7 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Phosphodiest PF01663.17 KII66533.1 - 8.7e-12 45.0 0.1 4e-11 42.8 0.1 1.8 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase CcoS PF03597.10 KII66533.1 - 1.1 8.7 3.8 2.7 7.5 2.6 1.7 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type DUF1546 PF07571.8 KII66536.1 - 6.9e-11 42.1 0.0 1.8e-10 40.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1546) TAF PF02969.12 KII66536.1 - 1.3e-10 41.0 0.1 3.5e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 KII66536.1 - 0.046 13.8 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Ribosomal_L17 PF01196.14 KII66537.1 - 0.069 13.7 0.1 0.098 13.2 0.1 1.5 1 1 0 1 1 1 0 Ribosomal protein L17 SRP14 PF02290.10 KII66538.1 - 0.00052 19.8 2.5 0.025 14.4 1.7 2.2 1 1 0 1 1 1 1 Signal recognition particle 14kD protein CD99L2 PF12301.3 KII66538.1 - 0.019 14.6 0.1 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 CD99 antigen like protein 2 zf-TRM13_CCCH PF11722.3 KII66538.1 - 5.8 6.3 7.0 0.44 9.9 1.0 1.9 2 0 0 2 2 2 0 CCCH zinc finger in TRM13 protein rve PF00665.21 KII66540.1 - 8.3e-24 83.9 0.0 2e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII66540.1 - 0.0014 18.0 0.0 0.0036 16.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF1829 PF08862.5 KII66541.1 - 0.071 13.3 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function DUF1829 UQ_con PF00179.21 KII66542.1 - 2.3e-22 78.9 0.5 2.7e-22 78.6 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 KII66542.1 - 0.045 13.4 0.9 0.079 12.6 0.6 1.4 1 1 0 1 1 1 0 UEV domain OB_NTP_bind PF07717.11 KII66543.1 - 2.6e-12 46.5 0.0 7e-12 45.1 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Tmemb_55A PF09788.4 KII66543.1 - 0.0078 15.3 0.7 0.012 14.7 0.5 1.1 1 0 0 1 1 1 1 Transmembrane protein 55A C1_4 PF07975.7 KII66543.1 - 0.45 10.5 3.7 14 5.7 0.1 2.5 2 0 0 2 2 2 0 TFIIH C1-like domain HA2 PF04408.18 KII66544.1 - 1.3e-08 34.7 0.0 1.8e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 KII66545.1 - 4.7e-07 29.5 0.0 1.2e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KII66545.1 - 4.9e-06 26.1 0.7 2.3e-05 23.9 0.2 2.3 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 KII66545.1 - 0.0007 19.4 0.0 0.085 12.6 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KII66545.1 - 0.00076 19.6 0.0 0.0021 18.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KII66545.1 - 0.0029 17.4 1.7 0.018 14.9 0.0 3.0 3 1 0 3 3 3 1 AAA domain T2SE PF00437.15 KII66545.1 - 0.025 13.4 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.1 KII66545.1 - 0.23 11.7 5.9 0.093 13.0 0.7 2.3 1 1 1 2 2 2 0 AAA domain Tetraspannin PF00335.15 KII66548.1 - 9.5 5.4 14.3 16 4.6 9.9 1.3 1 1 0 1 1 1 0 Tetraspanin family Josephin PF02099.12 KII66549.1 - 1e-16 60.9 0.3 1.2e-14 54.2 0.2 2.2 1 1 0 1 1 1 1 Josephin DUF4003 PF13170.1 KII66549.1 - 0.04 13.1 0.1 0.06 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4003) CDO_I PF05995.7 KII66549.1 - 0.08 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Cysteine dioxygenase type I Peptidase_C12 PF01088.16 KII66549.1 - 0.081 12.0 0.1 0.48 9.5 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase, family 1 DDE_3 PF13358.1 KII66550.1 - 9.9e-07 28.6 0.0 1.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII66551.1 - 2.1e-05 24.4 0.5 0.00047 20.1 0.1 2.3 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.1 KII66551.1 - 2.9e-05 23.5 0.0 7e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn helix HTH_29 PF13551.1 KII66551.1 - 0.0011 19.0 0.1 0.0017 18.4 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 KII66551.1 - 0.0064 16.2 0.1 0.009 15.7 0.1 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.1 KII66551.1 - 0.03 13.9 0.1 0.65 9.7 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain HTH_32 PF13565.1 KII66551.1 - 0.086 13.6 0.9 0.15 12.8 0.1 1.8 2 0 0 2 2 2 0 Homeodomain-like domain Ribosomal_L18e PF00828.14 KII66552.1 - 3.1e-34 118.1 0.1 4e-34 117.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 SbcCD_C PF13558.1 KII66553.1 - 5.8e-11 42.1 0.1 1.3e-10 41.0 0.1 1.6 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 KII66553.1 - 1.8e-08 33.9 0.1 2.2e-08 33.6 0.1 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KII66553.1 - 2.1e-05 24.6 0.5 2.7e-05 24.2 0.1 1.6 2 1 0 2 2 2 1 AAA domain Plant_all_beta PF10532.4 KII66553.1 - 0.00023 21.1 0.1 0.8 9.7 0.0 2.3 2 0 0 2 2 2 2 Plant specific N-all beta domain AAA_13 PF13166.1 KII66553.1 - 0.0046 15.4 0.2 0.0046 15.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain LytTR PF04397.10 KII66554.1 - 0.011 15.7 0.1 0.14 12.2 0.1 2.1 1 1 0 1 1 1 0 LytTr DNA-binding domain Syntaxin PF00804.20 KII66554.1 - 0.015 15.4 1.1 0.021 15.0 0.8 1.3 1 0 0 1 1 1 0 Syntaxin Baculo_PEP_C PF04513.7 KII66554.1 - 0.015 15.1 0.7 0.041 13.7 0.1 1.7 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MAD PF05557.8 KII66554.1 - 0.044 11.8 0.4 0.04 12.0 0.3 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Orthopox_F8 PF05886.6 KII66554.1 - 0.051 13.4 0.0 0.081 12.7 0.0 1.4 1 1 0 1 1 1 0 Orthopoxvirus F8 protein MscS_porin PF12795.2 KII66554.1 - 0.067 12.5 0.7 0.084 12.1 0.5 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain FlxA PF14282.1 KII66554.1 - 0.068 13.1 0.4 0.11 12.4 0.3 1.4 1 0 0 1 1 1 0 FlxA-like protein DUF3893 PF13032.1 KII66554.1 - 0.081 13.0 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3893) TelA PF05816.6 KII66554.1 - 0.11 11.1 0.2 0.11 11.1 0.2 1.0 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) Prefoldin_2 PF01920.15 KII66554.1 - 0.11 12.2 0.9 0.23 11.2 0.2 1.8 2 0 0 2 2 2 0 Prefoldin subunit Vip3A_N PF12495.3 KII66554.1 - 0.12 12.0 1.5 0.28 10.8 1.1 1.5 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal Syntaxin-6_N PF09177.6 KII66554.1 - 0.12 12.7 0.5 0.23 11.8 0.2 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF1090 PF06476.7 KII66554.1 - 0.14 11.8 1.4 0.13 11.9 0.4 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) HsbA PF12296.3 KII66554.1 - 0.16 11.8 0.4 0.34 10.7 0.1 1.7 2 1 0 2 2 2 0 Hydrophobic surface binding protein A Reo_sigmaC PF04582.7 KII66555.1 - 1 8.4 31.5 0.014 14.6 1.2 4.0 3 1 1 4 4 4 0 Reovirus sigma C capsid protein ASL_C2 PF14698.1 KII66555.1 - 1.2 9.2 4.9 7.7 6.6 0.0 3.8 4 0 0 4 4 4 0 Argininosuccinate lyase C-terminal V-ATPase_C PF03223.10 KII66556.1 - 0.00053 19.0 3.7 0.00074 18.5 2.5 1.5 1 1 0 1 1 1 1 V-ATPase subunit C DUF972 PF06156.8 KII66556.1 - 0.014 15.7 9.2 0.076 13.3 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Apt1 PF10351.4 KII66556.1 - 0.02 13.7 4.0 0.019 13.8 2.3 1.3 1 1 0 1 1 1 0 Golgi-body localisation protein domain RIX1 PF08167.7 KII66556.1 - 0.042 13.5 0.6 0.08 12.6 0.4 1.6 1 1 0 1 1 1 0 rRNA processing/ribosome biogenesis DUF869 PF05911.6 KII66556.1 - 0.072 11.3 7.4 0.1 10.7 5.1 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) NERD PF08378.6 KII66556.1 - 0.075 13.2 0.3 0.14 12.4 0.2 1.4 1 1 0 1 1 1 0 Nuclease-related domain Laminin_II PF06009.7 KII66556.1 - 0.082 12.6 10.1 0.039 13.6 4.1 2.0 1 1 1 2 2 2 0 Laminin Domain II Kinesin-relat_1 PF12711.2 KII66556.1 - 0.087 13.2 4.5 0.12 12.8 2.1 1.9 1 1 1 2 2 2 0 Kinesin motor Filament PF00038.16 KII66556.1 - 0.11 11.9 12.5 7.1 6.0 0.1 2.7 1 1 1 3 3 3 0 Intermediate filament protein DUF904 PF06005.7 KII66556.1 - 0.14 12.5 11.0 0.13 12.5 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Scaffolding_pro PF11418.3 KII66556.1 - 0.14 12.4 4.3 0.28 11.5 0.8 2.1 1 1 1 2 2 2 0 Phi29 scaffolding protein NPV_P10 PF05531.7 KII66556.1 - 0.17 12.1 11.0 15 5.9 3.9 3.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ALIX_LYPXL_bnd PF13949.1 KII66556.1 - 0.18 10.7 10.6 7.3 5.4 7.3 2.0 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV DivIC PF04977.10 KII66556.1 - 0.28 10.6 11.5 0.73 9.3 1.1 3.2 1 1 3 4 4 4 0 Septum formation initiator Vir_act_alpha_C PF10400.4 KII66556.1 - 0.34 11.3 3.4 0.35 11.2 0.4 2.2 1 1 2 3 3 3 0 Virulence activator alpha C-term UPF0118 PF01594.11 KII66556.1 - 0.39 9.6 2.4 0.54 9.1 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF20 Fib_alpha PF08702.5 KII66556.1 - 0.47 10.5 16.5 0.9 9.6 7.9 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.7 KII66556.1 - 0.54 10.0 9.0 0.33 10.7 3.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2203 PF09969.4 KII66556.1 - 0.56 10.4 3.4 1.3 9.2 0.8 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DP PF08781.5 KII66556.1 - 0.58 9.8 6.9 1.2 8.8 0.2 2.5 2 1 0 2 2 2 0 Transcription factor DP HALZ PF02183.13 KII66556.1 - 0.69 9.6 7.5 1 9.1 0.0 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper FlaC_arch PF05377.6 KII66556.1 - 0.83 9.6 6.8 4.7 7.1 0.1 3.6 2 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Nup54 PF13874.1 KII66556.1 - 0.84 9.2 7.4 0.32 10.6 2.3 2.1 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Tropomyosin_1 PF12718.2 KII66556.1 - 0.88 9.4 8.9 1.8 8.4 4.4 2.1 1 1 1 2 2 2 0 Tropomyosin like Prp18 PF02840.10 KII66556.1 - 1 9.1 6.1 0.22 11.3 0.6 2.3 1 1 2 3 3 3 0 Prp18 domain XhlA PF10779.4 KII66556.1 - 1.1 9.2 8.8 0.36 10.7 3.8 1.9 2 0 0 2 2 2 0 Haemolysin XhlA CENP-F_leu_zip PF10473.4 KII66556.1 - 1.3 8.8 10.9 13 5.6 7.6 2.2 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 KII66556.1 - 1.4 7.9 5.8 1.8 7.6 4.0 1.3 1 1 0 1 1 1 0 Reovirus sigma C capsid protein DUF3450 PF11932.3 KII66556.1 - 1.5 8.0 11.9 1 8.5 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) BLOC1_2 PF10046.4 KII66556.1 - 1.6 8.9 13.1 2.7 8.1 1.9 3.0 1 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4559 PF15112.1 KII66556.1 - 1.6 7.7 9.3 0.37 9.9 3.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) NYD-SP28 PF14772.1 KII66556.1 - 1.8 8.6 11.8 9.4 6.3 0.2 2.6 2 1 0 2 2 2 0 Sperm tail APG6 PF04111.7 KII66556.1 - 2.6 7.0 9.3 3.8 6.4 6.2 1.5 1 1 0 1 1 1 0 Autophagy protein Apg6 BBP1_C PF15272.1 KII66556.1 - 2.9 7.3 14.1 0.55 9.7 5.5 2.0 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal HemX PF04375.9 KII66556.1 - 3.5 6.1 10.4 0.68 8.4 0.3 2.1 1 1 1 2 2 2 0 HemX IncA PF04156.9 KII66556.1 - 4.4 6.8 15.9 21 4.6 10.9 1.9 1 1 0 1 1 1 0 IncA protein Sec2p PF06428.6 KII66556.1 - 5.5 6.9 9.9 3.9e+02 0.9 5.9 3.2 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p FERM_M PF00373.13 KII66556.1 - 5.5 7.1 6.4 3.7 7.7 0.6 2.3 1 1 1 2 2 2 0 FERM central domain DUF948 PF06103.6 KII66556.1 - 6.6 6.6 11.3 6 6.8 1.2 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) ATG16 PF08614.6 KII66556.1 - 7.8 6.2 15.5 1.4 8.6 7.3 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DDE_Tnp_IS1595 PF12762.2 KII66557.1 - 4.1e-22 78.6 0.0 6.2e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain rve PF00665.21 KII66559.1 - 6.8e-25 87.5 0.0 2e-24 85.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII66559.1 - 0.037 13.5 0.0 0.093 12.2 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS1595 PF12762.2 KII66561.1 - 3.1e-05 23.8 0.3 6.4e-05 22.8 0.2 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain Repressor_Mnt PF11423.3 KII66565.1 - 0.04 13.2 0.4 0.08 12.2 0.3 1.5 1 0 0 1 1 1 0 Regulatory protein Mnt DDE_3 PF13358.1 KII66566.1 - 1.5e-12 47.4 0.1 1.9e-12 47.1 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.1 KII66568.1 - 4.2e-08 32.6 5.9 1.7e-07 30.7 4.1 1.9 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP CysG_dimeriser PF10414.4 KII66569.1 - 0.23 10.9 3.7 0.4 10.1 2.5 1.4 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region SNAP PF14938.1 KII66571.1 - 1.3e-11 44.2 5.5 1.6e-11 43.8 3.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF3802 PF12290.3 KII66571.1 - 0.045 14.0 1.4 0.11 12.8 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) SPOB_a PF14689.1 KII66571.1 - 0.073 12.6 0.3 3.5 7.2 0.0 2.8 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain Enkurin PF13864.1 KII66571.1 - 0.081 13.1 2.0 0.29 11.3 1.4 1.9 1 1 0 1 1 1 0 Calmodulin-binding Apc3 PF12895.2 KII66571.1 - 0.4 10.8 4.5 0.27 11.3 0.8 2.2 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 APC8 PF04049.8 KII66571.1 - 4.6 6.9 7.4 1.8 8.2 0.3 2.2 1 1 1 2 2 2 0 Anaphase promoting complex subunit 8 / Cdc23 ALMS_motif PF15309.1 KII66576.1 - 0.11 12.3 0.3 0.11 12.3 0.2 1.9 2 1 0 2 2 2 0 ALMS motif RVT_1 PF00078.22 KII66577.1 - 3.2e-07 29.9 0.2 1.9e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Annexin PF00191.15 KII66577.1 - 0.65 9.9 3.1 0.57 10.1 0.1 2.5 3 0 0 3 3 3 0 Annexin rve PF00665.21 KII66581.1 - 6.5e-13 48.8 0.1 1.3e-12 47.8 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII66581.1 - 0.051 13.0 0.1 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.22 KII66582.1 - 0.034 13.5 0.1 0.06 12.6 0.1 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII66583.1 - 0.00069 19.4 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII66583.1 - 0.021 15.3 0.0 0.086 13.3 0.0 1.9 2 0 0 2 2 2 0 Aspartyl protease ScdA_N PF04405.9 KII66583.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown function (DUF542) DDE_3 PF13358.1 KII66591.1 - 0.003 17.3 0.0 0.13 12.0 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease Gal-3-0_sulfotr PF06990.6 KII66592.1 - 0.02 13.5 0.4 0.02 13.5 0.3 1.1 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase GATA PF00320.22 KII66593.1 - 2.9e-05 23.3 5.4 0.00011 21.4 3.7 2.1 1 0 0 1 1 1 1 GATA zinc finger Tnp_zf-ribbon_2 PF13842.1 KII66593.1 - 0.15 12.4 11.9 0.43 11.0 2.3 3.5 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon zf-Di19 PF05605.7 KII66593.1 - 0.18 11.9 1.5 0.62 10.2 0.1 2.6 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding C1_1 PF00130.17 KII66593.1 - 2.8 7.7 7.8 1 9.1 1.4 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.5 KII66593.1 - 4.4 7.3 6.7 15 5.6 0.3 3.1 3 0 0 3 3 3 0 Zinc ribbon domain DZR PF12773.2 KII66593.1 - 6.9 6.5 12.9 71 3.3 6.8 3.7 2 1 0 2 2 2 0 Double zinc ribbon Thioredoxin PF00085.15 KII66594.1 - 0.011 15.4 0.0 0.012 15.2 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin HyaE PF07449.6 KII66594.1 - 0.1 12.5 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE HTH_Tnp_Tc5 PF03221.11 KII66595.1 - 2.7e-13 49.5 0.1 4.5e-13 48.8 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 KII66595.1 - 0.00038 19.6 0.0 0.00074 18.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease MSA-2c PF12238.3 KII66597.1 - 0.002 17.8 0.6 0.009 15.7 0.2 1.9 2 0 0 2 2 2 1 Merozoite surface antigen 2c Pox_polyA_pol_N PF12630.2 KII66597.1 - 0.23 11.5 1.9 0.27 11.3 0.3 1.9 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain RVP PF00077.15 KII66598.1 - 2e-09 37.2 0.1 3.7e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Peptidase_A2E PF12382.3 KII66598.1 - 0.051 13.3 0.1 0.096 12.4 0.1 1.4 1 0 0 1 1 1 0 Retrotransposon peptidase Asp_protease_2 PF13650.1 KII66598.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.6 1 0 0 1 1 1 0 Aspartyl protease PHD PF00628.24 KII66598.1 - 1.2 8.8 5.7 2.7 7.7 4.0 1.6 1 0 0 1 1 1 0 PHD-finger zf-CCHC_4 PF14392.1 KII66598.1 - 4.3 7.0 7.7 7.6 6.2 0.9 2.5 2 0 0 2 2 2 0 Zinc knuckle PNPOx_C PF10590.4 KII66600.1 - 0.32 10.5 2.2 1.6 8.2 0.3 2.6 2 1 1 3 3 3 0 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region CDC14 PF08045.6 KII66601.1 - 0.0054 15.9 0.1 0.0065 15.6 0.0 1.1 1 0 0 1 1 1 1 Cell division control protein 14, SIN component KAP PF05804.7 KII66601.1 - 0.01 13.7 0.1 0.012 13.6 0.0 1.0 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) GIIM PF08388.6 KII66601.1 - 0.017 14.8 0.2 0.025 14.3 0.2 1.4 1 1 0 1 1 1 0 Group II intron, maturase-specific domain YwiC PF14256.1 KII66603.1 - 1.3 9.1 8.2 1.1 9.4 4.7 1.5 2 0 0 2 2 2 0 YwiC-like protein DUF3487 PF11990.3 KII66603.1 - 8 5.8 10.9 3.6 7.0 4.8 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3487) SNF2_N PF00176.18 KII66605.1 - 4.3e-58 196.4 4.2 3.1e-57 193.6 0.0 2.9 3 0 0 3 3 3 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.1 KII66605.1 - 7.6e-08 32.2 7.4 7.6e-08 32.2 5.1 4.4 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.26 KII66605.1 - 9.9e-08 31.7 0.0 2.7e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.1 KII66605.1 - 7.5e-07 28.8 6.6 7.5e-07 28.8 4.6 3.5 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.1 KII66605.1 - 1e-06 28.3 5.1 1e-06 28.3 3.5 3.9 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KII66605.1 - 1.1e-06 28.2 5.1 1.1e-06 28.2 3.5 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII66605.1 - 3.1e-05 23.5 5.8 3.1e-05 23.5 4.0 3.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KII66605.1 - 0.00069 19.4 8.1 0.00069 19.4 5.6 3.2 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-MIZ PF02891.15 KII66605.1 - 0.3 10.6 8.6 0.51 9.8 3.8 2.7 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_6 PF14835.1 KII66605.1 - 1.3 8.8 10.4 0.098 12.4 1.1 3.3 3 0 0 3 3 3 0 zf-RING of BARD1-type protein Proteasome PF00227.21 KII66606.1 - 5.5e-54 182.3 0.0 8.9e-54 181.6 0.0 1.3 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.4 KII66606.1 - 3e-11 42.4 0.1 5.4e-11 41.5 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature ELL PF10390.4 KII66607.1 - 0.22 10.7 2.9 0.2 10.8 0.1 2.0 2 0 0 2 2 2 0 RNA polymerase II elongation factor ELL Mg_trans_NIPA PF05653.9 KII66608.1 - 5.3e-17 61.7 11.9 2.6e-15 56.1 3.4 2.3 1 1 1 2 2 2 2 Magnesium transporter NIPA Rad21_Rec8 PF04824.11 KII66608.1 - 0.085 12.0 0.1 0.25 10.5 0.0 1.7 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein DDE_3 PF13358.1 KII66611.1 - 1.8e-18 66.7 0.0 2.5e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease IL3 PF02059.10 KII66614.1 - 0.098 12.6 1.1 4.8 7.1 0.1 2.8 2 0 0 2 2 2 0 Interleukin-3 zf-RING_2 PF13639.1 KII66615.1 - 1e-05 25.2 8.0 4.1e-05 23.3 5.5 2.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KII66615.1 - 0.00012 22.0 4.0 0.00048 20.1 2.8 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KII66615.1 - 0.00083 19.1 2.1 0.0024 17.6 1.5 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 KII66615.1 - 0.00097 19.0 5.5 0.0045 16.9 3.8 2.2 1 0 0 1 1 1 1 FANCL C-terminal domain C1_1 PF00130.17 KII66615.1 - 0.038 13.7 5.8 0.14 11.9 4.0 2.1 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RINGv PF12906.2 KII66615.1 - 0.097 12.7 7.9 0.39 10.7 5.5 2.2 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4 PF00097.20 KII66615.1 - 0.2 11.3 15.1 0.014 14.9 6.0 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 KII66615.1 - 2.2 8.3 6.8 8.6 6.4 4.7 2.2 1 0 0 1 1 1 0 RING-like domain DDE_Tnp_IS1595 PF12762.2 KII66617.1 - 1.7e-09 37.7 0.8 1.3e-08 34.8 0.6 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF3596 PF12167.3 KII66617.1 - 0.066 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3596) Patatin PF01734.17 KII66618.1 - 2.2e-11 44.0 2.1 4e-11 43.2 0.6 2.0 2 1 0 2 2 2 1 Patatin-like phospholipase Proteasom_PSMB PF10508.4 KII66622.1 - 0.072 11.3 0.0 0.078 11.2 0.0 1.0 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit Med21 PF11221.3 KII66623.1 - 0.023 14.6 0.2 0.048 13.6 0.2 1.4 2 0 0 2 2 2 0 Subunit 21 of Mediator complex SF-assemblin PF06705.6 KII66624.1 - 0.013 14.6 0.4 0.05 12.7 0.3 1.9 1 1 0 1 1 1 0 SF-assemblin/beta giardin Cytochrom_B562 PF07361.6 KII66624.1 - 0.12 12.8 0.0 5.1 7.5 0.0 2.4 3 0 0 3 3 3 0 Cytochrome b562 DUF2730 PF10805.3 KII66624.1 - 0.13 12.0 0.1 28 4.5 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) HTH_29 PF13551.1 KII66627.1 - 2.3e-10 40.6 0.1 3e-10 40.2 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII66627.1 - 7.4e-07 29.0 0.0 0.011 15.6 0.0 2.2 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_23 PF13384.1 KII66627.1 - 1.4e-06 27.7 0.3 0.0023 17.5 0.0 2.7 2 1 0 2 2 2 2 Homeodomain-like domain HTH_24 PF13412.1 KII66627.1 - 6.2e-05 22.2 0.3 0.00096 18.4 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Tnp_Tc3_2 PF01498.13 KII66627.1 - 0.00011 22.1 0.2 0.00048 20.1 0.0 2.0 2 0 0 2 2 2 1 Transposase MarR_2 PF12802.2 KII66627.1 - 0.00013 21.5 0.0 0.00031 20.3 0.0 1.6 2 0 0 2 2 1 1 MarR family PAX PF00292.13 KII66627.1 - 0.0002 21.0 0.0 0.00028 20.5 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.11 KII66627.1 - 0.00022 20.8 0.4 0.00027 20.5 0.3 1.1 1 0 0 1 1 1 1 Transposase HTH_38 PF13936.1 KII66627.1 - 0.00032 20.1 0.1 0.0063 16.0 0.0 2.5 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_32 PF13565.1 KII66627.1 - 0.00068 20.3 0.0 0.0012 19.5 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain B5 PF03484.10 KII66627.1 - 0.001 18.8 0.1 0.049 13.4 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetase B5 domain CENP-B_N PF04218.8 KII66627.1 - 0.0016 17.7 0.2 0.018 14.4 0.0 2.2 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_17 PF12728.2 KII66627.1 - 0.0019 18.4 0.0 2.3 8.5 0.0 2.3 2 0 0 2 2 2 2 Helix-turn-helix domain TrmB PF01978.14 KII66627.1 - 0.0019 17.8 0.1 0.018 14.7 0.0 2.2 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_33 PF13592.1 KII66627.1 - 0.0019 17.6 0.0 0.0062 16.0 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix MarR PF01047.17 KII66627.1 - 0.017 14.7 0.1 0.76 9.5 0.0 2.7 3 0 0 3 3 3 0 MarR family NUMOD1 PF07453.8 KII66627.1 - 0.02 14.7 0.1 0.047 13.5 0.1 1.6 1 0 0 1 1 1 0 NUMOD1 domain ssDNA-exonuc_C PF10141.4 KII66627.1 - 0.022 14.2 0.0 0.047 13.1 0.0 1.5 1 1 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain Fe_dep_repress PF01325.14 KII66627.1 - 0.024 14.5 0.0 0.085 12.8 0.0 1.9 3 0 0 3 3 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_3 PF01381.17 KII66627.1 - 0.026 14.3 0.5 0.41 10.5 0.1 2.7 2 1 0 3 3 3 0 Helix-turn-helix HTH_11 PF08279.7 KII66627.1 - 0.027 14.1 0.5 2.1 8.0 0.0 2.3 2 0 0 2 2 2 0 HTH domain HTH_Tnp_ISL3 PF13542.1 KII66627.1 - 0.032 13.4 0.2 0.76 9.0 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 HTH_40 PF14493.1 KII66627.1 - 0.04 14.1 1.0 0.074 13.2 0.6 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain Phage_CI_repr PF07022.8 KII66627.1 - 0.063 13.3 0.0 0.075 13.1 0.0 1.4 1 1 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain Stonin2_N PF12016.3 KII66629.1 - 0.041 13.0 0.0 0.049 12.7 0.0 1.1 1 0 0 1 1 1 0 Stonin 2 MULE PF10551.4 KII66631.1 - 0.0029 17.7 0.1 0.011 15.8 0.0 2.0 1 1 0 2 2 2 1 MULE transposase domain Ribosomal_S20p PF01649.13 KII66631.1 - 0.13 12.7 0.1 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S20 DDE_Tnp_IS1595 PF12762.2 KII66633.1 - 0.004 17.0 0.1 0.039 13.7 0.0 2.3 2 0 0 2 2 2 1 ISXO2-like transposase domain DALR_1 PF05746.10 KII66633.1 - 0.022 14.7 0.2 0.037 14.0 0.2 1.3 1 0 0 1 1 1 0 DALR anticodon binding domain rve PF00665.21 KII66635.1 - 2e-10 40.8 0.0 3.6e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII66635.1 - 0.012 15.5 0.1 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 DDE domain IpaB_EvcA PF03278.8 KII66635.1 - 0.029 13.5 0.1 0.034 13.3 0.1 1.2 1 0 0 1 1 1 0 IpaB/EvcA family BRCT_assoc PF12820.2 KII66638.1 - 0.099 12.3 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT Kelch_6 PF13964.1 KII66641.1 - 6.3e-12 45.1 13.7 0.01 15.9 0.0 5.5 5 1 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 KII66641.1 - 2.3e-10 40.3 7.2 0.00042 20.3 0.1 5.7 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.1 KII66641.1 - 1.4e-07 31.1 10.3 0.0058 16.3 0.1 5.7 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII66641.1 - 0.0004 19.8 17.1 0.13 11.8 0.4 5.6 5 1 0 5 5 5 2 Kelch motif Kelch_2 PF07646.10 KII66641.1 - 0.0083 15.8 6.4 21 5.0 0.0 4.8 4 1 0 4 4 4 1 Kelch motif MPC PF03650.8 KII66641.1 - 0.051 13.5 0.0 0.71 9.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0041) Kelch_5 PF13854.1 KII66641.1 - 0.18 11.7 2.3 0.83 9.6 0.1 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 KII66642.1 - 1.2e-07 31.5 2.8 0.00063 19.8 0.1 3.8 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 KII66642.1 - 0.039 14.1 0.2 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF2538 PF10804.3 KII66642.1 - 0.088 12.6 0.9 0.16 11.8 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2538) Kelch_3 PF13415.1 KII66643.1 - 0.00032 20.7 0.1 0.001 19.1 0.0 1.9 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KII66643.1 - 0.0065 16.2 1.0 0.041 13.6 0.1 2.2 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII66644.1 - 0.00011 22.2 15.4 0.26 11.5 0.2 5.3 4 3 0 4 4 4 3 Kelch motif Kelch_3 PF13415.1 KII66644.1 - 0.031 14.4 4.6 8.3 6.7 0.1 4.3 4 1 0 4 4 4 0 Galactose oxidase, central domain Kelch_2 PF07646.10 KII66644.1 - 0.052 13.3 4.9 7.2 6.5 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.20 KII66644.1 - 2.2 7.8 12.0 5.1 6.7 0.2 4.0 3 1 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 KII66647.1 - 1.4e-09 37.6 5.7 0.56 10.4 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 KII66647.1 - 6.5e-07 29.0 5.0 0.004 16.9 0.1 4.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII66647.1 - 8.6e-06 25.7 0.4 0.11 12.6 0.0 4.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII66647.1 - 0.00087 18.9 5.6 0.23 11.3 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.20 KII66647.1 - 0.038 13.5 0.1 0.038 13.5 0.1 5.2 7 0 0 7 7 7 0 Kelch motif Hepar_II_III PF07940.8 KII66647.1 - 0.048 13.4 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Heparinase II/III-like protein Kelch_5 PF13854.1 KII66647.1 - 0.058 13.3 3.4 1 9.3 0.0 3.4 4 0 0 4 4 4 0 Kelch motif gag-asp_proteas PF13975.1 KII66648.1 - 3.8e-05 23.4 0.0 8.3e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII66648.1 - 9.4e-05 22.8 0.0 0.00032 21.1 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.18 KII66648.1 - 0.0001 22.0 0.9 0.0001 22.0 0.6 2.9 2 1 0 2 2 2 1 Zinc knuckle RVP PF00077.15 KII66648.1 - 0.0032 17.3 0.0 0.0072 16.2 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII66648.1 - 0.091 12.3 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Serpin PF00079.15 KII66649.1 - 3.2e-49 168.0 4.7 3.8e-49 167.7 3.2 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII66650.1 - 1.5e-22 80.3 1.0 1.7e-22 80.0 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) BDM PF10684.4 KII66650.1 - 0.099 12.8 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 Putative biofilm-dependent modulation protein FLYWCH PF04500.11 KII66651.1 - 2.7e-10 39.9 1.2 4.8e-10 39.1 0.8 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain DUF3480 PF11979.3 KII66651.1 - 0.027 13.0 0.1 0.036 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3480) MULE PF10551.4 KII66652.1 - 2.2e-06 27.7 0.0 3.7e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 MULE transposase domain rve_3 PF13683.1 KII66652.1 - 0.1 12.1 0.1 0.25 10.8 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Ldl_recept_a PF00057.13 KII66654.1 - 0.00066 19.5 19.2 0.00066 19.5 13.3 3.5 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A OmpW PF03922.9 KII66655.1 - 0.013 15.1 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 OmpW family NUP PF06516.6 KII66655.1 - 0.074 11.8 0.2 0.24 10.1 0.0 1.7 1 1 0 2 2 2 0 Purine nucleoside permease (NUP) DUF211 PF02680.9 KII66660.1 - 0.066 13.0 0.2 0.086 12.6 0.1 1.3 1 1 0 1 1 1 0 Uncharacterized ArCR, COG1888 Kelch_6 PF13964.1 KII66665.1 - 3.8e-21 74.3 15.7 0.00014 21.8 0.0 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 KII66665.1 - 4.6e-16 58.4 15.7 0.00096 19.2 0.0 5.6 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII66665.1 - 1.9e-15 56.0 16.1 8e-05 22.1 0.2 5.6 5 1 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 KII66665.1 - 4.9e-15 55.0 18.6 0.00055 19.6 0.3 6.2 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII66665.1 - 5.2e-10 39.0 6.4 0.25 11.3 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KII66665.1 - 7.2e-08 31.9 9.9 0.24 11.2 0.1 5.3 5 0 0 5 5 5 3 Kelch motif Rax2 PF12768.2 KII66665.1 - 0.0057 15.9 0.3 0.27 10.4 0.0 2.3 1 1 1 2 2 2 1 Cortical protein marker for cell polarity EcsB PF05975.7 KII66668.1 - 0.0059 15.1 2.7 0.0072 14.8 1.9 1.1 1 0 0 1 1 1 1 Bacterial ABC transporter protein EcsB PseudoU_synth_1 PF01416.15 KII66670.1 - 4.7e-25 88.0 0.0 2.2e-15 56.9 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF258 PF03193.11 KII66671.1 - 0.047 12.8 0.0 0.092 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 KII66671.1 - 0.049 13.6 0.1 0.49 10.3 0.0 2.2 1 1 1 2 2 2 0 50S ribosome-binding GTPase TLD PF07534.11 KII66672.1 - 5e-12 45.9 0.1 1.2e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 TLD DUF502 PF04367.8 KII66673.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF502) DDE_Tnp_IS1595 PF12762.2 KII66674.1 - 4.8e-10 39.4 1.0 1.3e-09 38.0 0.7 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain HemY_N PF07219.8 KII66674.1 - 0.11 12.0 0.3 0.19 11.2 0.2 1.3 1 0 0 1 1 1 0 HemY protein N-terminus Evr1_Alr PF04777.8 KII66674.1 - 0.7 9.8 5.0 5.6 6.9 0.3 2.2 1 1 1 2 2 2 0 Erv1 / Alr family E1_DerP2_DerF2 PF02221.10 KII66676.1 - 0.0011 19.2 0.3 0.0047 17.1 0.2 1.8 1 1 1 2 2 2 2 ML domain E1_DerP2_DerF2 PF02221.10 KII66677.1 - 6.5e-05 23.2 0.0 8.1e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 ML domain ENOD93 PF03386.9 KII66677.1 - 0.093 12.4 0.1 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein E1_DerP2_DerF2 PF02221.10 KII66679.1 - 1.1e-08 35.4 0.0 1.3e-08 35.2 0.0 1.0 1 0 0 1 1 1 1 ML domain VWA_2 PF13519.1 KII66683.1 - 0.003 17.6 0.0 0.0036 17.4 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.15 KII66684.1 - 2.5e-07 29.6 6.1 0.00082 18.7 0.4 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif E1_DerP2_DerF2 PF02221.10 KII66688.1 - 2.6e-05 24.5 0.2 3.2e-05 24.2 0.1 1.1 1 0 0 1 1 1 1 ML domain RecO_N_2 PF13114.1 KII66690.1 - 0.1 12.3 0.7 2.1 8.1 0.1 2.2 2 0 0 2 2 2 0 RecO N terminal CENP-B_N PF04218.8 KII66696.1 - 0.076 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain BAR PF03114.13 KII66699.1 - 6.8e-13 48.6 0.0 1.2e-12 47.8 0.0 1.4 1 1 0 1 1 1 1 BAR domain LRR_4 PF12799.2 KII66700.1 - 1.4e-33 113.8 26.6 1.1e-08 34.4 2.0 5.4 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KII66700.1 - 2.3e-21 75.2 26.1 8.4e-07 28.6 2.3 4.4 3 2 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 KII66700.1 - 5.4e-14 50.0 28.1 0.14 12.2 0.1 9.3 9 0 0 9 9 9 5 Leucine Rich Repeat LRR_7 PF13504.1 KII66700.1 - 1.7e-13 48.3 13.3 1.3 9.5 0.0 9.4 8 1 0 8 8 8 2 Leucine rich repeat LRR_6 PF13516.1 KII66700.1 - 3.1e-09 35.9 17.2 1.3 9.3 0.0 9.1 5 2 3 8 8 8 2 Leucine Rich repeat LRR_9 PF14580.1 KII66700.1 - 2e-07 30.7 9.4 0.00061 19.3 0.4 2.5 1 1 1 2 2 2 2 Leucine-rich repeat FNIP PF05725.7 KII66700.1 - 0.083 12.8 9.9 2 8.4 0.2 4.3 3 1 0 3 3 3 0 FNIP Repeat Sigma70_r4 PF04545.11 KII66700.1 - 0.12 11.6 0.2 8.9 5.7 0.0 3.1 3 0 0 3 3 3 0 Sigma-70, region 4 DUF3744 PF12558.3 KII66700.1 - 0.45 10.9 4.2 2.8 8.4 0.2 3.6 2 1 1 4 4 4 0 ATP-binding cassette cobalt transporter Rap_GAP PF02145.10 KII66702.1 - 4.8e-20 71.7 0.3 1.1e-18 67.3 0.2 1.9 1 1 1 2 2 2 2 Rap/ran-GAP DDE_3 PF13358.1 KII66704.1 - 0.012 15.3 0.1 0.17 11.6 0.0 2.0 1 1 1 2 2 2 0 DDE superfamily endonuclease DDE_3 PF13358.1 KII66708.1 - 1.1e-08 34.9 0.0 1.7e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease RICTOR_M PF14666.1 KII66708.1 - 0.047 12.7 0.2 0.098 11.6 0.0 1.6 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain Tmem26 PF09772.4 KII66709.1 - 0.012 14.8 1.4 0.015 14.4 1.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 26 UCR_14kD PF02271.11 KII66709.1 - 0.091 12.5 0.1 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex 14kD subunit zf-CCHC PF00098.18 KII66710.1 - 1.6e-05 24.5 2.1 2.7e-05 23.8 1.4 1.3 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.1 KII66710.1 - 0.0046 16.7 0.1 0.0086 15.8 0.1 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII66710.1 - 0.1 12.2 2.0 0.29 10.8 1.4 1.7 1 0 0 1 1 1 0 Zinc knuckle RVP PF00077.15 KII66710.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII66710.1 - 0.34 11.4 1.3 0.74 10.3 0.2 2.1 3 0 0 3 3 3 0 Aspartyl protease DDE_3 PF13358.1 KII66714.1 - 0.0023 17.7 0.0 0.0026 17.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Branch PF02485.16 KII66715.1 - 0.0018 17.4 3.0 0.0042 16.2 1.8 1.8 1 1 0 1 1 1 1 Core-2/I-Branching enzyme DUF777 PF05606.6 KII66716.1 - 0.24 10.5 5.1 0.43 9.7 3.6 1.5 1 1 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF777) DUF3552 PF12072.3 KII66720.1 - 0.032 13.4 5.9 0.057 12.6 4.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Sulphotransf PF09037.5 KII66720.1 - 0.042 13.3 1.4 0.065 12.7 0.8 1.4 1 1 0 1 1 1 0 Stf0 sulphotransferase Tweety PF04906.8 KII66720.1 - 0.076 11.4 4.5 0.084 11.2 3.1 1.1 1 0 0 1 1 1 0 Tweety THP2 PF09432.5 KII66720.1 - 0.091 12.6 5.5 0.38 10.6 0.6 2.2 1 1 1 2 2 2 0 Tho complex subunit THP2 DUF3763 PF12592.3 KII66720.1 - 0.68 9.6 6.4 15 5.2 0.4 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3763) Rootletin PF15035.1 KII66720.1 - 0.73 9.7 11.5 0.25 11.2 2.1 2.1 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion GCN5L1 PF06320.8 KII66720.1 - 0.74 9.6 9.6 0.53 10.1 2.6 2.2 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF1319 PF07028.6 KII66720.1 - 1 9.5 7.3 0.9 9.7 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Prefoldin PF02996.12 KII66720.1 - 1.6 8.4 8.4 8 6.1 0.6 2.7 1 1 2 3 3 3 0 Prefoldin subunit PCI PF01399.22 KII66723.1 - 0.022 15.0 0.4 0.35 11.1 0.2 2.1 2 0 0 2 2 2 0 PCI domain UNC45-central PF11701.3 KII66723.1 - 0.031 13.9 0.4 0.16 11.6 0.0 2.0 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central TraE PF05309.6 KII66723.1 - 0.068 12.3 0.3 7.3 5.6 0.1 2.2 2 0 0 2 2 2 0 TraE protein DUF2672 PF10878.3 KII66724.1 - 0.14 11.8 1.2 0.26 11.0 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2672) rve PF00665.21 KII66728.1 - 9.7e-26 90.2 0.0 2.6e-25 88.8 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII66728.1 - 1.2e-06 27.9 0.1 2.7e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RICH PF05062.7 KII66728.1 - 0.25 11.5 3.1 0.27 11.3 1.1 1.8 2 0 0 2 2 2 0 RICH domain VCBS PF13517.1 KII66729.1 - 4.9e-05 23.5 0.2 0.0025 18.1 0.0 2.5 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII66729.1 - 0.0028 17.3 6.1 0.048 13.3 0.0 2.7 3 0 0 3 3 3 2 FG-GAP repeat RVT_1 PF00078.22 KII66733.1 - 1.4e-07 31.0 0.0 2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1948 PF09185.5 KII66733.1 - 0.052 13.1 0.1 0.088 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1948) DDE_3 PF13358.1 KII66736.1 - 3.5e-09 36.5 0.0 4e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII66738.1 - 0.015 15.3 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain rve PF00665.21 KII66739.1 - 3.1e-06 27.2 0.1 4.7e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII66739.1 - 0.00012 21.5 0.0 0.00022 20.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Tax PF02959.11 KII66742.1 - 0.036 13.5 0.0 0.049 13.0 0.0 1.2 1 1 0 1 1 1 0 HTLV Tax SVM_signal PF12113.3 KII66742.1 - 0.051 13.4 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 SVM protein signal sequence Retrotrans_gag PF03732.12 KII66743.1 - 0.11 12.5 0.5 0.35 10.9 0.1 2.1 2 0 0 2 2 2 0 Retrotransposon gag protein Transket_pyr PF02779.19 KII66745.1 - 9.4e-62 207.6 0.0 1.5e-61 206.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 KII66745.1 - 3.1e-55 187.0 0.1 4.5e-55 186.4 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component NHase_alpha PF02979.11 KII66745.1 - 0.02 14.1 0.0 0.045 13.0 0.0 1.5 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain DUF285 PF03382.9 KII66746.1 - 0.47 10.0 5.6 0.24 10.9 0.4 2.5 2 1 1 3 3 3 0 Mycoplasma protein of unknown function, DUF285 DUF3270 PF11674.3 KII66747.1 - 0.12 12.3 0.3 0.12 12.3 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3270) DUF1286 PF06939.6 KII66747.1 - 0.67 10.1 7.4 0.17 12.0 1.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1286) DUF912 PF06024.7 KII66747.1 - 2.2 8.3 10.5 0.17 11.9 0.4 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF805 PF05656.9 KII66747.1 - 7.3 6.4 17.3 1.5 8.6 2.1 3.6 1 1 1 2 2 2 0 Protein of unknown function (DUF805) zf-CCCH PF00642.19 KII66748.1 - 1.1e-13 50.5 13.3 8.1e-08 31.7 2.6 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KII66748.1 - 0.0051 16.7 6.8 0.12 12.4 0.5 3.0 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type M16C_assoc PF08367.6 KII66749.1 - 7.7e-06 24.9 0.1 1.1e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase M16C associated PSD4 PF07631.6 KII66749.1 - 0.11 12.8 0.1 0.21 11.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1592) RVT_1 PF00078.22 KII66750.1 - 4.7e-09 35.9 0.0 5.3e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.5 KII66751.1 - 0.0036 16.6 0.1 0.0061 15.9 0.1 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve PF00665.21 KII66752.1 - 4e-22 78.5 0.0 6.8e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII66752.1 - 0.00067 19.1 0.0 0.0015 17.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII66752.1 - 0.01 15.8 0.1 0.026 14.5 0.0 1.6 2 0 0 2 2 2 0 DDE domain DUF1571 PF07608.6 KII66752.1 - 0.05 12.7 0.0 0.083 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1571) Asp_protease_2 PF13650.1 KII66753.1 - 3.4e-05 24.2 0.0 4.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 KII66753.1 - 7.4e-05 22.6 0.2 9.5e-05 22.3 0.1 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 KII66753.1 - 0.00035 20.4 0.0 0.002 17.9 0.0 2.0 1 1 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII66753.1 - 0.0082 15.9 0.0 0.022 14.5 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII66753.1 - 0.12 11.9 0.1 0.31 10.5 0.1 1.6 1 1 0 1 1 1 0 Aspartyl protease PEP-utilizers PF00391.18 KII66753.1 - 0.16 11.5 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 PEP-utilising enzyme, mobile domain E1-E2_ATPase PF00122.15 KII66755.1 - 3.8e-62 209.3 0.2 7.7e-62 208.3 0.2 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 KII66755.1 - 2.1e-23 82.7 2.5 2.6e-23 82.4 0.1 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KII66755.1 - 2.8e-19 70.3 2.1 2.6e-18 67.2 1.4 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII66755.1 - 1.1e-15 57.3 0.0 2.2e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 KII66755.1 - 2.5e-11 42.8 0.8 7.3e-11 41.3 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 KII66755.1 - 1.8e-09 38.0 0.0 4e-09 36.9 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KII66755.1 - 0.0084 15.7 3.8 0.0084 15.7 2.7 2.4 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase PP2C_2 PF13672.1 KII66755.1 - 0.046 13.1 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein phosphatase 2C DUF1884 PF08967.5 KII66756.1 - 0.034 14.1 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1884) DUF2951 PF11166.3 KII66758.1 - 0.13 12.1 0.9 0.16 11.8 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) Integrin_beta PF00362.13 KII66759.1 - 2.3e-17 63.0 4.7 7.6e-17 61.3 3.3 1.8 1 1 0 1 1 1 1 Integrin, beta chain EGF_2 PF07974.8 KII66759.1 - 1.8e-08 34.3 51.9 0.002 18.2 5.0 4.6 3 1 1 4 4 4 3 EGF-like domain Dimer_Tnp_hAT PF05699.9 KII66760.1 - 0.00033 20.2 0.5 0.0008 18.9 0.1 1.8 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region LUC7 PF03194.10 KII66761.1 - 4.4e-27 95.2 0.0 8.6e-26 90.9 0.0 2.0 1 1 0 1 1 1 1 LUC7 N_terminus EGF_2 PF07974.8 KII66762.1 - 0.00025 21.1 13.5 0.00075 19.6 9.3 1.9 1 0 0 1 1 1 1 EGF-like domain Sigma_reg_N PF13800.1 KII66762.1 - 0.059 13.3 2.9 0.14 12.2 2.0 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DDE_Tnp_IS1595 PF12762.2 KII66763.1 - 3.7e-11 43.0 0.1 4.3e-11 42.8 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain HSP20 PF00011.16 KII66764.1 - 3.3e-20 71.8 1.1 1.9e-09 37.2 0.2 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family HSP20 PF00011.16 KII66765.1 - 1.2e-24 86.1 0.6 1.7e-14 53.4 0.0 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family DUF3794 PF12673.2 KII66765.1 - 0.06 13.4 1.0 0.85 9.8 0.7 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3794) DUF4097 PF13349.1 KII66765.1 - 0.089 12.3 0.7 0.4 10.2 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4097) PTH2 PF01981.11 KII66766.1 - 4.1e-25 87.7 0.0 5.5e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 SIR2 PF02146.12 KII66766.1 - 0.049 13.3 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 Sir2 family Cofilin_ADF PF00241.15 KII66767.1 - 4.9e-13 49.0 0.1 5.8e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein AGT PF11440.3 KII66767.1 - 0.052 12.4 0.1 0.063 12.1 0.1 1.1 1 0 0 1 1 1 0 DNA alpha-glucosyltransferase AAA PF00004.24 KII66768.1 - 2e-41 141.2 0.1 9.9e-41 139.0 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KII66768.1 - 3e-06 27.3 0.0 0.00039 20.5 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 KII66768.1 - 1.1e-05 25.1 0.1 0.00011 21.9 0.0 2.6 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KII66768.1 - 1.6e-05 25.0 0.0 3.8e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 KII66768.1 - 0.00019 21.3 0.0 0.00046 20.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 KII66768.1 - 0.001 19.8 0.1 0.0027 18.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KII66768.1 - 0.0012 17.8 0.0 0.0023 17.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 KII66768.1 - 0.0013 18.4 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain DUF815 PF05673.8 KII66768.1 - 0.0022 16.9 0.0 0.0036 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.1 KII66768.1 - 0.0075 16.3 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_14 PF13173.1 KII66768.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KII66768.1 - 0.012 15.7 0.0 0.032 14.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.12 KII66768.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.1 KII66768.1 - 0.014 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KII66768.1 - 0.015 15.1 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 KII66768.1 - 0.019 13.7 0.0 0.032 12.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus T2SE PF00437.15 KII66768.1 - 0.022 13.6 0.0 0.036 12.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 KII66768.1 - 0.022 13.8 0.0 0.04 13.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 KII66768.1 - 0.025 14.8 0.1 0.073 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 KII66768.1 - 0.038 13.1 0.0 0.083 12.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 KII66768.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KII66768.1 - 0.054 12.9 0.0 0.17 11.3 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.6 KII66768.1 - 0.057 13.0 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 KII66768.1 - 0.06 12.7 0.1 0.28 10.5 0.0 2.0 1 1 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KII66768.1 - 0.063 12.9 1.5 2.9 7.5 0.0 2.9 2 1 1 3 3 3 0 Archaeal ATPase Parvo_NS1 PF01057.12 KII66768.1 - 0.17 10.7 0.0 0.3 9.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CTD_bind PF04818.8 KII66769.1 - 0.036 14.3 3.4 6.9 7.0 0.0 3.7 2 1 0 2 2 2 0 RNA polymerase II-binding domain. Cyclin_N PF00134.18 KII66771.1 - 0.0008 18.9 0.0 0.0017 17.9 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ig_J_chain PF15097.1 KII66771.1 - 0.014 15.0 0.6 0.16 11.5 0.4 2.2 1 1 0 1 1 1 0 Immunoglobulin J chain Septin PF00735.13 KII66772.1 - 1.1e-78 264.0 0.1 1.3e-78 263.9 0.0 1.0 1 0 0 1 1 1 1 Septin AAA_22 PF13401.1 KII66772.1 - 0.00036 20.6 0.0 0.0013 18.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII66772.1 - 0.001 19.0 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.1 KII66772.1 - 0.0019 17.3 1.1 0.0022 17.1 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain MobB PF03205.9 KII66772.1 - 0.0036 17.0 0.0 0.0089 15.7 0.0 1.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Pox_A32 PF04665.7 KII66772.1 - 0.0092 15.2 0.1 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein AAA_33 PF13671.1 KII66772.1 - 0.03 14.1 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KII66772.1 - 0.041 13.5 0.0 0.081 12.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 KII66772.1 - 0.045 14.0 0.1 0.1 12.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter G-alpha PF00503.15 KII66772.1 - 0.048 12.3 1.5 3.9 6.0 0.3 2.3 1 1 0 2 2 2 0 G-protein alpha subunit GTP_EFTU PF00009.22 KII66772.1 - 0.077 12.4 0.1 5.2 6.4 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KII66772.1 - 0.088 12.7 0.1 0.18 11.7 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Miro PF08477.8 KII66772.1 - 0.089 13.2 0.1 0.55 10.7 0.0 2.1 1 1 1 2 2 2 0 Miro-like protein TnpV PF14198.1 KII66773.1 - 0.074 12.9 0.1 5.1 7.0 0.0 2.6 2 0 0 2 2 2 0 Transposon-encoded protein TnpV DDE_3 PF13358.1 KII66774.1 - 3.5e-19 68.9 0.0 4.3e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII66774.1 - 0.03 13.4 0.0 0.035 13.2 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease tRNA-synt_2d PF01409.15 KII66774.1 - 0.057 12.5 0.0 0.068 12.3 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) HTH_29 PF13551.1 KII66775.1 - 4.3e-10 39.7 0.2 6.5e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII66775.1 - 5.8e-10 38.5 0.5 2e-07 30.4 0.1 3.0 3 0 0 3 3 3 1 Homeodomain-like domain PAX PF00292.13 KII66775.1 - 7.3e-10 38.6 0.4 1.1e-09 38.0 0.3 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_28 PF13518.1 KII66775.1 - 1.2e-08 34.7 3.2 4.1e-08 33.0 0.3 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_32 PF13565.1 KII66775.1 - 1.9e-07 31.7 0.1 4.8e-07 30.4 0.0 1.7 2 0 0 2 2 1 1 Homeodomain-like domain HTH_33 PF13592.1 KII66775.1 - 0.00066 19.1 0.1 0.0019 17.7 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.1 KII66775.1 - 0.0013 17.8 1.7 0.019 14.1 0.1 2.9 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 HTH_24 PF13412.1 KII66775.1 - 0.005 16.2 1.5 0.011 15.0 0.1 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding TrmB PF01978.14 KII66775.1 - 0.014 15.0 0.2 0.051 13.2 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_38 PF13936.1 KII66775.1 - 0.017 14.6 1.2 0.055 13.0 0.8 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_IS1 PF12759.2 KII66775.1 - 0.024 14.0 0.4 0.024 14.0 0.3 2.6 3 1 0 3 3 3 0 InsA C-terminal domain HMG_CoA_synt_N PF01154.12 KII66775.1 - 0.025 14.1 0.1 0.032 13.7 0.1 1.1 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal HTH_Tnp_Tc3_2 PF01498.13 KII66775.1 - 0.03 14.3 2.0 0.038 14.0 0.3 2.0 2 0 0 2 2 2 0 Transposase HTH_Tnp_1 PF01527.15 KII66775.1 - 0.034 14.0 0.9 0.25 11.3 0.0 2.3 2 1 1 3 3 2 0 Transposase SpoIIID PF12116.3 KII66775.1 - 0.035 14.0 1.2 0.24 11.3 0.2 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D MarR_2 PF12802.2 KII66775.1 - 0.042 13.5 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_11 PF08279.7 KII66775.1 - 0.084 12.5 1.3 6.5 6.4 0.0 2.3 2 0 0 2 2 2 0 HTH domain Sigma70_r4 PF04545.11 KII66775.1 - 0.11 11.8 0.1 0.3 10.4 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_3 PF01381.17 KII66775.1 - 0.13 12.1 0.0 0.45 10.3 0.0 1.9 2 0 0 2 2 1 0 Helix-turn-helix Sigma70_r4_2 PF08281.7 KII66775.1 - 0.16 11.4 0.3 0.5 9.8 0.0 2.0 2 0 0 2 2 1 0 Sigma-70, region 4 DUF359 PF04019.7 KII66775.1 - 0.18 11.1 1.4 0.58 9.5 1.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF359) DUF1323 PF07037.6 KII66775.1 - 0.34 11.0 2.4 0.62 10.2 0.1 2.1 1 1 1 2 2 2 0 Putative transcription regulator (DUF1323) HSP20 PF00011.16 KII66777.1 - 2.1e-17 62.8 1.1 1.5e-09 37.6 0.2 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family R3H PF01424.17 KII66778.1 - 0.098 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 R3H domain ATP_bind_2 PF03668.10 KII66778.1 - 0.12 11.4 0.1 0.18 10.8 0.1 1.2 1 0 0 1 1 1 0 P-loop ATPase protein family HSP20 PF00011.16 KII66779.1 - 6.6e-19 67.6 1.1 3.2e-08 33.3 0.0 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family VPS9 PF02204.13 KII66780.1 - 2.2e-15 56.5 0.5 2.2e-15 56.5 0.4 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain zf-CCHC PF00098.18 KII66781.1 - 4.5e-07 29.4 3.9 8e-07 28.7 2.7 1.4 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.1 KII66781.1 - 0.0011 18.6 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII66781.1 - 0.0031 17.1 1.2 0.0079 15.8 0.8 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.1 KII66781.1 - 0.0044 16.6 3.0 0.011 15.4 2.1 1.6 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.15 KII66781.1 - 0.078 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII66781.1 - 0.079 13.4 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_3 PF13917.1 KII66781.1 - 0.11 12.2 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle ERG4_ERG24 PF01222.12 KII66783.1 - 0.00026 19.6 1.6 0.00028 19.5 1.1 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1673 PF07895.6 KII66783.1 - 0.023 14.2 2.5 0.031 13.8 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) ERG4_ERG24 PF01222.12 KII66784.1 - 3.8e-55 187.1 8.5 4.3e-55 186.9 5.9 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 KII66784.1 - 0.022 14.0 0.8 0.033 13.4 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) ICMT PF04140.9 KII66784.1 - 0.093 12.9 0.4 0.25 11.5 0.0 1.7 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF3899 PF13038.1 KII66785.1 - 0.023 14.8 0.7 0.023 14.8 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Cor1 PF04803.7 KII66785.1 - 0.33 10.6 10.4 0.96 9.2 7.2 1.8 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region ATP-synt_ab_C PF00306.22 KII66785.1 - 1.5 9.3 7.9 1.7 9.1 2.4 2.3 1 1 1 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain Usp PF00582.21 KII66786.1 - 2.8e-07 30.8 0.0 3.9e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Usp PF00582.21 KII66787.1 - 2.1e-15 57.1 0.0 4.8e-15 55.9 0.0 1.5 1 1 0 1 1 1 1 Universal stress protein family Ribosomal_L44 PF00935.14 KII66788.1 - 5.2e-11 42.3 4.6 8.1e-11 41.7 3.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L44 YpjP PF14005.1 KII66790.1 - 0.34 10.6 3.6 0.16 11.7 0.2 2.2 3 0 0 3 3 3 0 YpjP-like protein DUF2999 PF11212.3 KII66791.1 - 0.029 14.4 0.0 1.9 8.5 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2999) TLD PF07534.11 KII66793.1 - 7.6e-06 25.9 0.0 1.9e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 TLD DDOST_48kD PF03345.9 KII66794.1 - 9e-73 245.1 0.1 1.1e-72 244.9 0.1 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta AMMECR1 PF01871.12 KII66795.1 - 1.4e-40 138.2 0.0 1.8e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 DUF3733 PF12534.3 KII66798.1 - 0.00072 18.7 0.0 0.00072 18.7 0.0 2.1 2 0 0 2 2 2 1 Leucine-rich repeat containing protein 8 OTU PF02338.14 KII66798.1 - 0.0018 18.8 0.0 0.0047 17.4 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease SRP_SPB PF02978.14 KII66800.1 - 0.023 14.9 0.1 0.032 14.4 0.1 1.2 1 0 0 1 1 1 0 Signal peptide binding domain rve PF00665.21 KII66802.1 - 2e-09 37.5 0.0 6.9e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII66802.1 - 1.1e-08 34.7 0.1 0.00014 21.3 0.2 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII66802.1 - 3.2e-06 26.9 0.0 9.3e-06 25.4 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII66802.1 - 0.00061 20.2 0.0 0.0014 19.0 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII66802.1 - 0.027 14.3 0.0 0.06 13.1 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII66803.1 - 0.056 13.4 2.7 0.056 13.4 1.9 2.8 3 0 0 3 3 3 0 Zinc knuckle DDE_1 PF03184.14 KII66804.1 - 1.2e-16 60.5 0.0 4.4e-11 42.3 0.1 2.7 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF2089 PF09862.4 KII66804.1 - 0.12 12.1 0.3 0.64 9.8 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2089) UspB PF10625.4 KII66806.1 - 0.28 10.9 1.7 1.1 9.0 0.4 2.1 1 1 1 2 2 2 0 Universal stress protein B (UspB) Ras PF00071.17 KII66807.1 - 1.5e-22 79.7 0.0 1.7e-22 79.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Arf PF00025.16 KII66807.1 - 8.5e-12 44.6 0.1 9.7e-12 44.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 KII66807.1 - 1.7e-09 38.2 0.1 2.1e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 KII66807.1 - 3.2e-06 26.4 0.0 3.9e-06 26.1 0.0 1.0 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 KII66807.1 - 6.5e-05 22.2 0.0 7.7e-05 21.9 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 KII66807.1 - 0.00022 21.1 0.0 0.00024 21.0 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.1 KII66807.1 - 0.0032 17.1 0.2 0.0036 16.9 0.2 1.3 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 KII66807.1 - 0.0035 16.8 0.1 0.0043 16.5 0.1 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.22 KII66807.1 - 0.0069 15.8 0.0 0.0081 15.6 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 KII66807.1 - 0.023 14.8 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain PRK PF00485.13 KII66807.1 - 0.023 14.2 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DUF258 PF03193.11 KII66807.1 - 0.025 13.7 0.1 0.03 13.5 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 KII66807.1 - 0.026 14.8 0.1 0.029 14.6 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.1 KII66807.1 - 0.044 13.3 0.0 0.12 11.8 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 KII66807.1 - 0.046 12.8 0.0 0.055 12.5 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin UPF0079 PF02367.12 KII66807.1 - 0.05 13.2 0.1 0.086 12.4 0.1 1.3 1 1 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 G-alpha PF00503.15 KII66807.1 - 0.075 11.7 0.2 0.41 9.2 0.0 1.8 1 1 1 2 2 2 0 G-protein alpha subunit ATP_bind_1 PF03029.12 KII66807.1 - 0.077 12.5 0.1 0.77 9.2 0.1 1.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein FeoB_N PF02421.13 KII66807.1 - 0.12 11.6 0.1 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Ferrous iron transport protein B RNA_helicase PF00910.17 KII66807.1 - 0.15 12.2 0.1 0.18 11.9 0.0 1.4 1 1 0 1 1 1 0 RNA helicase SRP54 PF00448.17 KII66807.1 - 0.15 11.4 0.4 1.4 8.3 0.1 1.9 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain SGS PF05002.10 KII66808.1 - 5.9e-23 80.4 0.5 1.1e-22 79.5 0.3 1.4 1 0 0 1 1 1 1 SGS domain CS PF04969.11 KII66808.1 - 2e-14 53.8 0.1 3.5e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 CS domain HAUS-augmin3 PF14932.1 KII66810.1 - 0.003 16.7 1.0 0.0036 16.5 0.7 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF1664 PF07889.7 KII66810.1 - 0.25 11.1 2.0 0.4 10.4 1.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DDE_3 PF13358.1 KII66812.1 - 2.1e-10 40.5 0.0 2.5e-10 40.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease BNR PF02012.15 KII66813.1 - 0.0017 17.8 0.9 1.2 9.2 0.1 3.1 2 0 0 2 2 2 2 BNR/Asp-box repeat TetM_leader PF08076.6 KII66813.1 - 0.014 14.9 4.3 0.021 14.3 0.1 2.5 2 0 0 2 2 2 0 Tetracycline resistance determinant leader peptide DUF3753 PF12575.3 KII66814.1 - 0.5 10.2 2.6 8.3 6.2 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) DUF3671 PF12420.3 KII66816.1 - 0.064 13.2 3.0 0.11 12.4 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function COG4 PF08318.7 KII66817.1 - 0.024 13.4 0.0 0.027 13.2 0.0 1.0 1 0 0 1 1 1 0 COG4 transport protein RVT_1 PF00078.22 KII66818.1 - 4e-18 65.5 0.0 8.2e-18 64.5 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.9 KII66818.1 - 0.09 11.7 0.0 0.21 10.5 0.0 1.6 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Biotin_carb_C PF02785.14 KII66818.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain Kinesin-relat_1 PF12711.2 KII66818.1 - 0.19 12.1 0.7 0.33 11.3 0.2 1.6 2 0 0 2 2 2 0 Kinesin motor zf-CCHC PF00098.18 KII66819.1 - 0.00027 20.7 0.8 0.00027 20.7 0.6 2.4 2 0 0 2 2 2 1 Zinc knuckle NifW PF03206.9 KII66819.1 - 0.019 15.0 0.3 0.26 11.4 0.0 2.2 2 0 0 2 2 2 0 Nitrogen fixation protein NifW ODAM PF15424.1 KII66819.1 - 0.04 13.3 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Odontogenic ameloblast-associated family DUF3542 PF12061.3 KII66821.1 - 0.036 13.0 0.0 0.05 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3542) COMPASS-Shg1 PF05205.7 KII66823.1 - 0.071 13.4 0.3 0.085 13.1 0.2 1.3 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 DUF2244 PF10003.4 KII66824.1 - 0.18 11.1 0.7 0.25 10.6 0.5 1.2 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Fmp27_WPPW PF10359.4 KII66825.1 - 0.0033 15.8 0.6 0.0043 15.5 0.4 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Asp_protease_2 PF13650.1 KII66825.1 - 0.048 14.1 0.0 0.13 12.7 0.0 1.8 2 1 0 2 2 2 0 Aspartyl protease HTH_23 PF13384.1 KII66828.1 - 0.00015 21.3 0.0 0.0018 17.8 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII66828.1 - 0.00077 19.4 0.1 0.00077 19.4 0.0 2.2 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_29 PF13551.1 KII66828.1 - 0.067 13.3 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix Lipoprotein_3 PF00938.12 KII66828.1 - 0.075 12.8 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Lipoprotein PAX PF00292.13 KII66828.1 - 0.13 11.9 0.1 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 'Paired box' domain Sigma70_r4_2 PF08281.7 KII66828.1 - 0.14 11.6 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 DUF484 PF04340.7 KII66829.1 - 0.067 12.6 0.0 0.071 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF484 Frag1 PF10277.4 KII66830.1 - 0.0084 15.6 4.6 0.0099 15.3 2.8 1.3 1 1 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF4077 PF13295.1 KII66830.1 - 0.029 14.0 4.7 0.038 13.7 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4077) Pox_A14 PF05767.7 KII66830.1 - 0.047 13.6 7.5 1.2 9.1 0.6 2.1 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 Claudin_2 PF13903.1 KII66830.1 - 0.064 12.9 0.5 0.064 12.9 0.3 2.0 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.1 KII66830.1 - 0.17 11.9 10.2 1.5 8.9 7.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) MARVEL PF01284.18 KII66830.1 - 0.36 10.6 10.8 0.98 9.2 7.4 1.7 1 1 0 1 1 1 0 Membrane-associating domain Rab5ip PF07019.7 KII66830.1 - 1.4 9.0 9.5 0.27 11.3 1.2 2.6 1 1 2 3 3 3 0 Rab5-interacting protein (Rab5ip) DUF1772 PF08592.6 KII66830.1 - 1.6 8.4 6.2 23 4.7 3.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) DUF4149 PF13664.1 KII66830.1 - 3.1 7.9 11.2 9 6.4 3.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) DUF202 PF02656.10 KII66830.1 - 4.3 7.6 9.5 0.35 11.1 0.6 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DDE_Tnp_IS1595 PF12762.2 KII66831.1 - 0.00037 20.3 0.1 0.0017 18.1 0.1 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain PCMT PF01135.14 KII66832.1 - 7.8e-59 198.7 0.0 1e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KII66832.1 - 9.9e-06 25.2 0.0 1.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KII66832.1 - 0.00052 20.0 0.0 0.00071 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KII66832.1 - 0.00079 19.9 0.0 0.0013 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KII66832.1 - 0.002 17.7 0.0 0.007 16.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII66832.1 - 0.011 16.1 0.0 0.039 14.4 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain MetW PF07021.7 KII66832.1 - 0.018 14.4 0.1 0.055 12.8 0.1 1.9 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW TehB PF03848.9 KII66832.1 - 0.025 13.7 0.0 0.044 12.9 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB MTS PF05175.9 KII66832.1 - 0.039 13.3 0.1 0.079 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.8 KII66832.1 - 0.042 12.9 0.0 0.052 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.1 KII66832.1 - 0.089 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 KII66832.1 - 0.1 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 PCMT PF01135.14 KII66833.1 - 8.9e-20 71.1 0.0 1.1e-19 70.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KII66833.1 - 0.00011 21.7 0.0 0.00013 21.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 KII66833.1 - 0.00099 18.2 0.0 0.0012 17.8 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 KII66833.1 - 0.0079 16.7 0.0 0.01 16.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KII66833.1 - 0.0086 15.8 0.0 0.009 15.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KII66833.1 - 0.01 15.4 0.0 0.013 15.1 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain N2227 PF07942.7 KII66837.1 - 2.3e-59 200.6 0.3 3e-59 200.1 0.2 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.7 KII66837.1 - 0.0064 16.9 0.0 0.047 14.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII66837.1 - 0.03 13.8 0.1 0.07 12.7 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KII66837.1 - 0.04 13.6 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_2 PF09068.6 KII66837.1 - 0.048 13.7 0.1 0.4 10.7 0.0 2.2 1 1 1 2 2 2 0 EF hand Nol1_Nop2_Fmu PF01189.12 KII66838.1 - 5.6e-32 111.2 0.0 7.2e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 NOL1/NOP2/sun family FtsJ PF01728.14 KII66838.1 - 0.061 13.3 0.0 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 FtsJ-like methyltransferase Nol1_Nop2_Fmu PF01189.12 KII66839.1 - 0.0059 16.0 0.7 0.01 15.2 0.0 1.7 2 1 0 2 2 2 1 NOL1/NOP2/sun family PP_kinase_N PF13089.1 KII66839.1 - 0.86 9.7 4.4 2.2 8.4 2.7 1.9 1 1 0 1 1 1 0 Polyphosphate kinase N-terminal domain AA_permease_2 PF13520.1 KII66840.1 - 3.1e-40 137.9 54.1 4e-40 137.6 37.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII66840.1 - 1e-23 83.4 50.0 1.4e-23 82.9 34.6 1.1 1 0 0 1 1 1 1 Amino acid permease N2227 PF07942.7 KII66841.1 - 8.8e-67 224.9 1.3 1.1e-66 224.6 0.9 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 KII66841.1 - 6.5e-05 22.7 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII66841.1 - 0.00024 20.7 0.1 0.0082 15.7 0.1 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KII66841.1 - 0.00031 21.1 0.0 0.0012 19.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII66841.1 - 0.02 15.3 0.1 0.25 11.8 0.1 2.5 1 1 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 KII66841.1 - 0.063 12.2 0.0 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family LCM PF04072.9 KII66842.1 - 1.2e-30 106.3 0.0 2e-30 105.7 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase MTS PF05175.9 KII66842.1 - 0.0057 16.0 0.0 0.0087 15.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DUF1125 PF06563.6 KII66843.1 - 0.088 12.5 0.3 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1125) Ribosomal_S13 PF00416.17 KII66844.1 - 3.2e-35 120.7 1.7 3.8e-35 120.5 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 IMS_HHH PF11798.3 KII66844.1 - 0.069 13.2 0.5 0.17 11.9 0.4 1.7 1 0 0 1 1 1 0 IMS family HHH motif Cpn60_TCP1 PF00118.19 KII66845.1 - 1.1e-63 215.6 1.4 1.2e-63 215.4 1.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RNA_pol_Rpb2_7 PF04560.15 KII66848.1 - 1.7e-31 108.2 0.0 2.1e-31 108.0 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 Ribosomal_L37ae PF01780.14 KII66848.1 - 0.021 14.7 0.4 0.034 13.9 0.3 1.3 1 0 0 1 1 1 0 Ribosomal L37ae protein family RNA_POL_M_15KD PF02150.11 KII66848.1 - 0.041 13.5 0.5 0.09 12.4 0.3 1.7 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.2 KII66848.1 - 0.28 10.9 1.9 0.31 10.8 0.5 1.7 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Cript PF10235.4 KII66848.1 - 0.4 11.0 3.0 0.34 11.2 0.3 1.9 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT LANC_like PF05147.8 KII66849.1 - 0.0068 15.0 0.0 0.01 14.4 0.0 1.2 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Telomerase_RBD PF12009.3 KII66850.1 - 1.1e-17 64.2 4.2 4.1e-17 62.3 2.9 2.0 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 KII66850.1 - 0.0011 18.4 0.1 0.017 14.4 0.1 2.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LBR_tudor PF09465.5 KII66851.1 - 0.0036 16.9 0.0 0.0089 15.6 0.0 1.7 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain DUF1325 PF07039.6 KII66851.1 - 0.021 14.4 0.0 0.058 13.0 0.0 1.6 2 0 0 2 2 2 0 SGF29 tudor-like domain DUF4537 PF15057.1 KII66851.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4537) FERM_N PF09379.5 KII66852.1 - 4.6e-17 61.8 0.8 1.4e-16 60.2 0.1 2.2 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.13 KII66852.1 - 5e-14 52.5 0.0 9.6e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.5 KII66852.1 - 3.8e-13 49.4 0.6 3.8e-13 49.4 0.4 2.3 2 1 0 2 2 2 1 FERM C-terminal PH-like domain FA PF08736.6 KII66852.1 - 9.7e-07 28.4 6.5 9.7e-07 28.4 4.5 1.8 2 0 0 2 2 2 1 FERM adjacent (FA) SM-ATX PF14438.1 KII66852.1 - 0.052 13.4 0.3 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Ataxin 2 SM domain P4Ha_N PF08336.6 KII66853.1 - 1e-10 41.5 0.6 1.1e-09 38.2 0.4 2.1 1 1 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.1 KII66854.1 - 0.00035 21.0 0.0 0.00067 20.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily A2L_zn_ribbon PF08792.5 KII66855.1 - 0.74 9.3 0.1 0.74 9.3 0.0 2.7 3 1 0 3 3 3 0 A2L zinc ribbon domain DEAD PF00270.24 KII66857.1 - 1.2e-09 37.9 0.0 1.8e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase TK PF00265.13 KII66857.1 - 0.0032 17.0 0.2 0.0092 15.5 0.1 1.7 1 1 1 2 2 2 1 Thymidine kinase AAA PF00004.24 KII66857.1 - 0.021 14.9 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.18 KII66857.1 - 0.064 12.0 0.7 0.07 11.9 0.5 1.3 1 1 0 1 1 1 0 SNF2 family N-terminal domain DEAD PF00270.24 KII66858.1 - 3.5e-05 23.3 0.0 3.8e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 KII66858.1 - 0.0016 17.3 0.0 0.002 17.0 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein 7TM_GPCR_Srt PF10321.4 KII66858.1 - 0.011 14.5 0.9 0.013 14.3 0.6 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srt Sec63 PF02889.11 KII66859.1 - 0.00054 19.2 0.2 0.0015 17.8 0.2 1.6 1 1 0 1 1 1 1 Sec63 Brl domain Paf1 PF03985.8 KII66860.1 - 2.9e-10 39.4 2.9 3.7e-10 39.1 2.0 1.0 1 0 0 1 1 1 1 Paf1 FliM PF02154.10 KII66861.1 - 0.095 12.3 1.1 2.1 7.9 0.0 2.2 2 0 0 2 2 2 0 Flagellar motor switch protein FliM NT5C PF06941.7 KII66864.1 - 0.097 12.1 0.0 0.21 11.0 0.0 1.5 2 0 0 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) DSHCT PF08148.7 KII66871.1 - 1.2e-54 184.2 0.0 3e-54 182.9 0.0 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.1 KII66871.1 - 6.5e-40 136.9 4.5 1.3e-39 136.0 3.1 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.24 KII66871.1 - 3.7e-23 81.8 0.0 8.6e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII66871.1 - 1.2e-06 28.2 0.0 5.5e-06 26.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain T2SE PF00437.15 KII66871.1 - 0.045 12.6 0.0 0.087 11.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein HC2 PF07382.6 KII66874.1 - 2.4e-11 43.8 9.6 2.9e-11 43.6 6.7 1.1 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 FLYWCH PF04500.11 KII66875.1 - 2.7e-11 43.1 3.7 4.7e-11 42.4 1.9 1.9 2 0 0 2 2 2 1 FLYWCH zinc finger domain MULE PF10551.4 KII66875.1 - 3.1e-11 43.2 0.0 9.4e-11 41.7 0.0 1.8 1 0 0 1 1 1 1 MULE transposase domain zf-CCHC_5 PF14787.1 KII66876.1 - 0.0015 17.9 4.2 0.0031 16.9 2.9 1.5 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-ribbon_3 PF13248.1 KII66876.1 - 0.13 11.4 1.3 0.25 10.6 0.3 1.9 2 0 0 2 2 2 0 zinc-ribbon domain MULE PF10551.4 KII66878.1 - 4.3e-05 23.5 0.1 7.4e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 MULE transposase domain Methyltransf_27 PF13708.1 KII66878.1 - 0.076 12.5 0.1 0.081 12.4 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain ATP-synt_D PF01813.12 KII66879.1 - 1.1e-51 175.1 1.2 1.4e-51 174.8 0.8 1.1 1 0 0 1 1 1 1 ATP synthase subunit D DASH_Spc19 PF08287.6 KII66879.1 - 0.032 13.8 3.8 0.28 10.7 0.8 2.2 2 0 0 2 2 2 0 Spc19 RhoGAP PF00620.22 KII66879.1 - 0.05 13.2 0.4 0.13 11.8 0.3 1.6 2 0 0 2 2 2 0 RhoGAP domain Thioredoxin PF00085.15 KII66880.1 - 9e-46 153.8 0.1 2.3e-21 75.3 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 KII66880.1 - 8.3e-18 64.8 7.1 1.3e-13 51.1 2.9 2.7 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KII66880.1 - 2e-10 40.6 1.7 0.00042 20.3 0.0 3.5 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.1 KII66880.1 - 2e-08 34.3 3.8 0.0015 18.6 0.1 4.6 4 1 0 4 4 4 2 Thioredoxin-like domain AhpC-TSA PF00578.16 KII66880.1 - 5.9e-07 29.2 1.1 0.0011 18.6 0.1 3.1 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_7 PF13899.1 KII66880.1 - 1.9e-06 27.7 3.2 0.013 15.4 0.0 4.1 4 2 0 4 4 4 2 Thioredoxin-like Thioredoxin_9 PF14595.1 KII66880.1 - 2.7e-06 26.9 0.3 0.35 10.4 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Redoxin PF08534.5 KII66880.1 - 0.00025 20.6 4.4 0.025 14.1 0.3 3.7 4 0 0 4 4 4 1 Redoxin TraF PF13728.1 KII66880.1 - 0.013 15.0 0.1 7.5 5.9 0.0 3.5 4 0 0 4 4 4 0 F plasmid transfer operon protein Glutaredoxin PF00462.19 KII66880.1 - 0.042 13.8 0.0 5 7.1 0.0 2.9 2 0 0 2 2 2 0 Glutaredoxin WD40 PF00400.27 KII66881.1 - 1.2e-45 151.7 5.1 3.6e-09 36.1 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KII66881.1 - 0.00032 18.9 0.9 0.43 8.6 0.0 2.8 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 KII66881.1 - 0.031 12.5 0.0 0.13 10.5 0.0 1.9 2 1 0 2 2 2 0 Cytochrome D1 heme domain RVT_1 PF00078.22 KII66882.1 - 0.00081 18.8 0.9 0.0012 18.2 0.2 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII66883.1 - 5.5e-23 81.3 0.0 8.5e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII66883.1 - 2.2e-06 27.0 0.0 7.7e-06 25.3 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain ATG11 PF10377.4 KII66883.1 - 0.0049 16.7 0.1 0.0084 16.0 0.1 1.4 1 0 0 1 1 1 1 Autophagy-related protein 11 HTH_29 PF13551.1 KII66884.1 - 8.4e-10 38.7 0.0 1.3e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII66884.1 - 5.5e-08 32.2 0.6 1.1e-05 24.8 0.0 2.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.1 KII66884.1 - 2e-07 30.4 0.2 0.00021 20.7 0.0 3.6 3 1 0 3 3 3 1 Helix-turn-helix domain HTH_28 PF13518.1 KII66884.1 - 7.2e-07 29.1 0.3 2.3e-05 24.3 0.1 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.13 KII66884.1 - 0.00035 20.2 0.1 0.00062 19.4 0.1 1.5 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.1 KII66884.1 - 0.0021 17.8 0.1 0.0062 16.2 0.0 1.8 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII66884.1 - 0.0029 17.2 0.3 0.0049 16.5 0.2 1.4 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII66884.1 - 0.0032 18.2 0.0 0.0097 16.6 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII66884.1 - 0.0047 16.9 0.1 0.023 14.7 0.0 2.1 2 1 0 2 2 2 1 Transposase HTH_11 PF08279.7 KII66884.1 - 0.013 15.0 0.3 0.029 14.0 0.2 1.6 1 0 0 1 1 1 0 HTH domain HTH_7 PF02796.10 KII66884.1 - 0.031 14.1 1.5 0.22 11.3 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase HTH_40 PF14493.1 KII66884.1 - 0.039 14.1 0.4 0.12 12.6 0.1 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Ribosomal_S21 PF01165.15 KII66884.1 - 0.044 13.2 0.1 0.87 9.0 0.1 2.4 2 0 0 2 2 2 0 Ribosomal protein S21 Herpes_BLRF2 PF05812.7 KII66884.1 - 0.057 13.2 0.2 0.23 11.2 0.0 1.9 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein TrmB PF01978.14 KII66884.1 - 0.061 13.0 0.2 0.42 10.3 0.0 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_Tnp_1 PF01527.15 KII66884.1 - 0.097 12.6 0.3 0.17 11.8 0.0 1.7 2 0 0 2 2 1 0 Transposase LIM PF00412.17 KII66885.1 - 8e-47 157.1 51.0 1.9e-12 47.0 4.6 4.3 4 0 0 4 4 4 4 LIM domain Sgf11 PF08209.6 KII66885.1 - 0.25 10.6 0.1 0.25 10.6 0.1 7.1 9 0 0 9 9 9 0 Sgf11 (transcriptional regulation protein) DDE_3 PF13358.1 KII66886.1 - 1.5e-12 47.4 0.0 1.8e-12 47.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Thioredoxin PF00085.15 KII66887.1 - 3.1e-20 71.8 0.0 3.9e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 KII66887.1 - 0.002 18.2 0.1 0.37 10.9 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 KII66887.1 - 0.0023 18.0 0.0 0.038 14.1 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KII66887.1 - 0.025 14.5 0.2 0.042 13.8 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like RWP-RK PF02042.10 KII66887.1 - 0.14 12.0 0.0 0.32 10.8 0.0 1.6 2 0 0 2 2 2 0 RWP-RK domain DDE_Tnp_IS1595 PF12762.2 KII66888.1 - 1.3e-05 25.0 0.7 5.1e-05 23.1 0.3 1.8 1 1 1 2 2 2 1 ISXO2-like transposase domain Sialidase PF02973.11 KII66888.1 - 0.063 12.2 0.1 0.12 11.3 0.0 1.4 1 1 0 1 1 1 0 Sialidase, N-terminal domain rve PF00665.21 KII66889.1 - 1.2e-05 25.4 0.0 1.8e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain P22_Cro PF14549.1 KII66889.1 - 0.12 12.1 0.9 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 DNA-binding transcriptional regulator Cro gag-asp_proteas PF13975.1 KII66891.1 - 2e-07 30.7 0.0 3.4e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII66891.1 - 6.5e-06 26.5 0.0 9.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII66891.1 - 7.2e-05 22.6 0.0 0.00013 21.8 0.0 1.5 1 1 0 1 1 1 1 Retroviral aspartyl protease TAF4 PF05236.9 KII66895.1 - 0.00041 19.7 6.2 0.00065 19.0 2.9 2.1 1 1 1 2 2 2 1 Transcription initiation factor TFIID component TAF4 family DDE_1 PF03184.14 KII66896.1 - 0.00023 20.3 0.1 0.00031 19.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease MarR_2 PF12802.2 KII66898.1 - 0.038 13.6 0.1 0.081 12.6 0.0 1.5 1 0 0 1 1 1 0 MarR family Post_transc_reg PF13797.1 KII66898.1 - 0.041 13.4 0.2 0.083 12.4 0.1 1.4 1 0 0 1 1 1 0 Post-transcriptional regulator Imm6 PF14434.1 KII66898.1 - 0.072 12.7 0.1 0.26 11.0 0.0 1.8 2 1 0 2 2 2 0 Immunity protein Imm6 cNMP_binding PF00027.24 KII66898.1 - 0.099 12.4 0.2 0.29 10.9 0.1 1.9 2 1 0 2 2 2 0 Cyclic nucleotide-binding domain cNMP_binding PF00027.24 KII66899.1 - 0.00089 19.0 0.0 0.0035 17.1 0.0 1.9 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain TrmB PF01978.14 KII66899.1 - 0.0071 16.0 0.1 0.016 14.8 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.2 KII66899.1 - 0.0076 15.8 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 MarR family DUF2450 PF10475.4 KII66899.1 - 0.026 13.4 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) Rrf2 PF02082.15 KII66899.1 - 0.05 13.7 0.1 0.086 12.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator DUF2250 PF10007.4 KII66899.1 - 0.059 13.2 0.8 0.078 12.8 0.1 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) zf-met PF12874.2 KII66900.1 - 7.2e-12 45.0 13.6 4.2e-07 29.9 0.4 3.6 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KII66900.1 - 1.2e-07 31.6 13.5 3.1e-05 23.9 0.5 3.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 KII66900.1 - 0.00011 22.2 17.4 0.045 13.8 3.7 3.8 2 2 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.7 KII66900.1 - 0.12 12.0 0.2 0.12 12.0 0.1 3.1 4 0 0 4 4 4 0 DBF zinc finger DDE_Tnp_IS1595 PF12762.2 KII66902.1 - 5.1e-05 23.1 0.2 0.00011 22.0 0.2 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain Kunitz_BPTI PF00014.18 KII66903.1 - 0.0083 16.3 8.6 0.0083 16.3 6.0 1.9 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain ACP53EA PF06313.6 KII66907.1 - 0.1 12.5 0.2 8.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Drosophila ACP53EA protein RVT_1 PF00078.22 KII66908.1 - 0.013 14.8 0.4 4.5 6.5 0.0 3.1 2 1 1 3 3 3 0 Reverse transcriptase (RNA-dependent DNA polymerase) SpoU_methylas_C PF12105.3 KII66909.1 - 0.11 12.0 0.2 3.6 7.2 0.0 2.2 2 0 0 2 2 2 0 SpoU, rRNA methylase, C-terminal GRAM PF02893.15 KII66911.1 - 0.025 14.0 0.0 0.079 12.4 0.0 1.8 1 0 0 1 1 1 0 GRAM domain Serpin PF00079.15 KII66913.1 - 6.4e-34 117.6 3.9 1e-32 113.7 2.7 2.0 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) CDC45 PF02724.9 KII66913.1 - 0.34 8.8 6.1 0.47 8.4 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-CCHC PF00098.18 KII66914.1 - 0.00019 21.2 3.0 0.00036 20.3 2.1 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.1 KII66914.1 - 0.18 11.5 0.1 0.18 11.5 0.1 2.0 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.21 KII66915.1 - 8.8e-07 29.0 0.0 1.2e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Serpin PF00079.15 KII66916.1 - 1.6e-46 159.1 0.1 1.1e-41 143.2 0.0 2.1 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) CDC45 PF02724.9 KII66916.1 - 0.6 8.0 14.7 0.77 7.7 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 KII66916.1 - 1.2 8.4 15.7 1.8 7.8 10.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Serpin PF00079.15 KII66918.1 - 1.9e-46 158.8 2.1 3.8e-42 144.7 1.0 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) Serpin PF00079.15 KII66920.1 - 2.2e-06 27.0 0.0 2.2e-06 27.0 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII66922.1 - 0.00051 19.2 0.0 0.0045 16.1 0.0 2.0 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DAP3 PF10236.4 KII66922.1 - 0.12 11.2 0.3 0.15 10.9 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Serpin PF00079.15 KII66923.1 - 1.8e-19 70.1 0.0 2.1e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII66924.1 - 4.8e-19 68.7 0.2 1e-17 64.3 0.1 2.0 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) CDC45 PF02724.9 KII66924.1 - 0.006 14.6 5.0 0.0074 14.3 3.5 1.0 1 0 0 1 1 1 1 CDC45-like protein Serpin PF00079.15 KII66925.1 - 9.5e-09 34.8 0.0 1.1e-08 34.6 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RVT_1 PF00078.22 KII66926.1 - 2.6e-09 36.7 0.0 9.2e-09 34.9 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.9 KII66926.1 - 0.006 16.5 0.1 0.021 14.7 0.0 1.8 1 1 1 2 2 2 1 Spumavirus aspartic protease (A9) Apc4 PF12896.2 KII66926.1 - 0.028 13.7 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 PDGF_N PF04692.8 KII66926.1 - 0.14 12.6 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region RVT_1 PF00078.22 KII66927.1 - 0.0026 17.1 0.1 0.0084 15.4 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cas_Cmr5 PF09701.5 KII66927.1 - 0.03 14.5 0.3 11 6.2 0.3 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cmr5) rve PF00665.21 KII66928.1 - 1.1e-26 93.2 0.0 1.4e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII66928.1 - 0.00031 20.2 0.0 0.0017 17.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII66928.1 - 0.0044 16.9 0.0 0.0055 16.6 0.0 1.1 1 0 0 1 1 1 1 DDE domain Transcript_VP30 PF11507.3 KII66928.1 - 0.017 14.9 0.1 0.25 11.1 0.0 2.1 1 1 1 2 2 2 0 Ebola virus-specific transcription factor VP30 Nop PF01798.13 KII66929.1 - 0.14 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Putative snoRNA binding domain Mtp PF03821.11 KII66933.1 - 0.002 17.5 0.5 0.0023 17.3 0.3 1.1 1 0 0 1 1 1 1 Golgi 4-transmembrane spanning transporter Ndc1_Nup PF09531.5 KII66933.1 - 0.018 13.5 0.2 0.02 13.3 0.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ASFV_J13L PF05568.6 KII66933.1 - 0.18 11.2 0.5 0.28 10.7 0.4 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein IncA PF04156.9 KII66934.1 - 0.2 11.2 0.1 0.2 11.2 0.1 3.9 3 1 0 3 3 3 0 IncA protein CAAP1 PF15335.1 KII66934.1 - 0.28 11.3 5.7 0.33 11.1 0.1 3.4 3 0 0 3 3 3 0 Caspase activity and apoptosis inhibitor 1 MbeD_MobD PF04899.7 KII66934.1 - 0.54 10.2 5.1 2.2 8.2 0.1 3.5 4 0 0 4 4 4 0 MbeD/MobD like Enkurin PF13864.1 KII66934.1 - 4.6 7.5 9.2 0.2 11.9 0.6 2.9 3 0 0 3 3 3 0 Calmodulin-binding DUF2250 PF10007.4 KII66936.1 - 0.14 12.0 0.1 0.17 11.8 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) zf-dskA_traR PF01258.12 KII66938.1 - 0.026 14.2 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger rve PF00665.21 KII66940.1 - 1.8e-08 34.5 0.0 4.2e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain F-box PF00646.28 KII66942.1 - 0.027 14.1 0.3 0.1 12.3 0.1 2.0 2 0 0 2 2 2 0 F-box domain LRR_1 PF00560.28 KII66942.1 - 1.4 9.2 7.3 19 5.8 0.4 4.6 4 1 0 4 4 4 0 Leucine Rich Repeat zf-HC5HC2H_2 PF13832.1 KII66945.1 - 0.087 12.8 0.1 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain GTP_EFTU PF00009.22 KII66946.1 - 0.1 11.9 0.6 0.13 11.6 0.4 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Fib_alpha PF08702.5 KII66946.1 - 1 9.4 7.3 1.3 9.1 5.1 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DDE_3 PF13358.1 KII66948.1 - 1.6e-06 27.9 0.1 0.029 14.1 0.0 2.8 1 1 0 2 2 2 2 DDE superfamily endonuclease A1_Propeptide PF07966.7 KII66948.1 - 0.028 14.2 0.0 15 5.5 0.0 2.9 2 0 0 2 2 2 0 A1 Propeptide Glycos_transf_2 PF00535.21 KII66948.1 - 0.11 12.1 0.0 1.3 8.6 0.0 2.3 2 1 1 3 3 3 0 Glycosyl transferase family 2 FliJ PF02050.11 KII66949.1 - 0.0038 17.2 5.5 0.12 12.4 1.5 2.8 1 1 2 3 3 3 1 Flagellar FliJ protein DUF749 PF05370.6 KII66949.1 - 0.0059 16.5 0.5 0.57 10.1 0.0 2.5 2 1 1 3 3 3 1 Domain of unknown function (DUF749) DSX_dimer PF08828.5 KII66949.1 - 0.012 15.0 3.4 0.59 9.7 0.6 2.7 1 1 1 2 2 2 0 Doublesex dimerisation domain DUF4618 PF15397.1 KII66949.1 - 0.04 13.2 3.4 0.14 11.4 2.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Spc7 PF08317.6 KII66949.1 - 0.045 12.4 4.0 0.21 10.2 0.5 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF3920 PF13058.1 KII66949.1 - 0.074 12.8 2.0 0.1 12.4 1.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3920) Spectrin PF00435.16 KII66949.1 - 0.13 12.5 3.3 1.7 8.9 2.0 2.2 1 1 1 2 2 2 0 Spectrin repeat DUF1910 PF08928.5 KII66949.1 - 0.21 11.6 3.6 0.3 11.1 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1910) Pox_A6 PF04924.7 KII66949.1 - 0.57 8.9 5.0 2.2 6.9 0.1 2.1 1 1 1 2 2 2 0 Poxvirus A6 protein DUF2130 PF09903.4 KII66949.1 - 0.64 8.7 6.0 1.1 7.9 2.3 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) DUF641 PF04859.7 KII66949.1 - 0.67 9.7 4.1 6.1 6.6 0.4 2.5 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) PLC-beta_C PF08703.5 KII66949.1 - 1.3 8.6 9.4 1.5 8.5 6.5 1.1 1 0 0 1 1 1 0 PLC-beta C terminal Fib_alpha PF08702.5 KII66949.1 - 1.5 8.9 5.5 13 5.8 3.8 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family P4Ha_N PF08336.6 KII66949.1 - 1.8 8.4 7.0 10 5.9 0.9 2.3 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DDE_3 PF13358.1 KII66952.1 - 1.3e-09 37.9 0.0 1.6e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4322 PF14210.1 KII66952.1 - 0.0097 15.3 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4322) CUB PF00431.15 KII66953.1 - 4.5e-23 81.4 1.6 4.5e-23 81.4 1.1 4.4 6 0 0 6 6 6 1 CUB domain Nup96 PF12110.3 KII66954.1 - 0.0049 16.0 1.9 0.013 14.6 0.2 2.2 2 0 0 2 2 2 1 Nuclear protein 96 TPR_1 PF00515.23 KII66954.1 - 0.0051 16.3 0.3 0.059 13.0 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII66954.1 - 0.011 15.4 0.0 1.7 8.3 0.0 2.8 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.12 KII66954.1 - 0.023 14.5 0.0 0.33 10.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII66955.1 - 1.5e-10 40.5 4.0 1e-05 25.0 0.3 3.1 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KII66955.1 - 3.5e-05 23.4 1.5 0.6 10.1 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_3 PF07720.7 KII66955.1 - 0.00011 21.8 2.3 0.097 12.4 0.0 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII66955.1 - 0.00059 19.3 5.3 0.039 13.5 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KII66955.1 - 0.0036 17.9 0.3 10 6.9 0.0 3.7 4 1 1 5 5 4 1 Tetratricopeptide repeat Apc3 PF12895.2 KII66955.1 - 0.0077 16.3 4.2 0.0077 16.3 2.9 4.6 4 1 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 KII66955.1 - 0.0098 16.0 2.3 0.7 10.2 0.2 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KII66955.1 - 0.014 16.0 0.0 42 5.1 0.0 4.5 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 KII66955.1 - 0.051 13.5 5.9 3.3 7.7 0.6 3.7 2 2 0 2 2 2 0 Tetratricopeptide repeat DUF3932 PF13068.1 KII66955.1 - 0.08 13.0 2.2 0.35 10.9 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3932) TPR_6 PF13174.1 KII66955.1 - 0.72 10.4 5.3 13 6.5 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat LIM PF00412.17 KII66956.1 - 1.3e-11 44.3 7.6 2.6e-11 43.4 5.3 1.5 1 0 0 1 1 1 1 LIM domain SH3_9 PF14604.1 KII66956.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 KII66956.1 - 0.0017 17.6 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 SH3 domain Nebulin PF00880.13 KII66956.1 - 0.013 15.0 0.0 0.035 13.7 0.0 1.8 1 0 0 1 1 1 0 Nebulin repeat Sigma70_r4 PF04545.11 KII66957.1 - 0.0013 18.0 0.7 0.002 17.4 0.0 1.6 2 0 0 2 2 2 1 Sigma-70, region 4 CENP-B_N PF04218.8 KII66957.1 - 0.0015 17.9 0.0 0.0036 16.6 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.1 KII66957.1 - 0.0029 17.5 0.0 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Ku_PK_bind PF08785.6 KII66957.1 - 0.0074 16.1 0.0 1.7 8.5 0.0 2.6 1 1 1 2 2 2 2 Ku C terminal domain like HTH_psq PF05225.11 KII66957.1 - 0.018 14.5 0.1 0.031 13.8 0.1 1.3 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_23 PF13384.1 KII66957.1 - 0.026 14.1 0.0 0.057 13.0 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain Spermine_synth PF01564.12 KII66960.1 - 1.1e-71 240.7 0.3 1.4e-71 240.2 0.2 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 KII66960.1 - 6.6e-08 32.2 0.0 9.8e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KII66960.1 - 0.0074 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.9 KII66960.1 - 0.017 14.4 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_12 PF08242.7 KII66960.1 - 0.039 14.4 0.0 0.078 13.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.6 KII66960.1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.7 KII66960.1 - 0.14 11.5 0.2 0.33 10.3 0.1 1.7 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW CBFD_NFYB_HMF PF00808.18 KII66961.1 - 6.2e-15 55.0 0.2 1.2e-14 54.1 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KII66961.1 - 0.00077 19.5 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.8 KII66961.1 - 0.0054 16.9 1.0 0.0097 16.1 0.7 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TAF4 PF05236.9 KII66961.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.2 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Ribosomal_L3 PF00297.17 KII66962.1 - 0.0018 17.7 0.0 0.0028 17.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L3 Chordopox_A30L PF06015.7 KII66963.1 - 0.089 12.4 5.2 0.15 11.6 2.9 2.0 1 1 1 2 2 2 0 Chordopoxvirus A30L protein Misat_Tub_SegII PF10644.4 KII66963.1 - 0.37 10.8 2.2 0.43 10.6 0.2 1.9 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain LSM PF01423.17 KII66964.1 - 6.9e-18 63.9 0.2 8.6e-18 63.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain Leu_zip PF15294.1 KII66964.1 - 0.0093 15.1 0.2 0.011 14.8 0.1 1.1 1 0 0 1 1 1 1 Leucine zipper LVIVD PF08309.6 KII66967.1 - 0.12 11.3 0.7 0.29 10.1 0.5 1.6 1 0 0 1 1 1 0 LVIVD repeat rve PF00665.21 KII66968.1 - 6.7e-25 87.5 0.0 1.8e-24 86.1 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII66968.1 - 0.035 13.6 0.0 0.084 12.4 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Peptidase_A2E PF12382.3 KII66969.1 - 0.00062 19.5 0.4 0.0014 18.4 0.3 1.6 1 1 0 1 1 1 1 Retrotransposon peptidase RVP PF00077.15 KII66969.1 - 0.02 14.8 0.0 0.051 13.5 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.1 KII66970.1 - 0.00012 21.6 3.6 0.04 13.5 0.1 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.1 KII66970.1 - 0.0008 19.0 11.7 0.012 15.3 1.1 2.3 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.18 KII66970.1 - 0.015 15.1 3.8 0.015 15.1 2.6 2.2 2 0 0 2 2 2 0 Zinc knuckle ADK_lid PF05191.9 KII66970.1 - 0.088 12.4 1.1 2 8.1 0.1 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid DUF897 PF05982.7 KII66973.1 - 0.016 14.0 0.1 0.021 13.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF897) Helitron_like_N PF14214.1 KII66974.1 - 1.1e-11 44.8 2.8 2.1e-09 37.3 0.0 3.0 2 1 1 3 3 3 2 Helitron helicase-like domain at N-terminus Striatin PF08232.7 KII66975.1 - 0.082 13.2 1.5 0.12 12.6 1.0 1.2 1 0 0 1 1 1 0 Striatin family Epimerase PF01370.16 KII66976.1 - 8.3e-45 153.0 0.0 1.2e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KII66976.1 - 3.9e-08 32.5 0.0 1.6e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 KII66976.1 - 1.7e-06 27.1 0.0 0.0032 16.3 0.0 3.0 2 1 1 3 3 3 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 KII66976.1 - 0.00015 20.5 0.1 0.0043 15.8 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1647 PF07801.6 KII66976.1 - 0.032 13.7 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) NAD_binding_4 PF07993.7 KII66976.1 - 0.14 11.0 0.0 0.71 8.7 0.0 1.9 1 1 1 2 2 2 0 Male sterility protein TypeIII_RM_meth PF12564.3 KII66977.1 - 0.092 12.7 0.2 0.31 11.0 0.0 1.9 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit TIMELESS PF04821.9 KII66978.1 - 2.5e-14 53.2 1.0 6e-14 51.9 0.7 1.7 1 0 0 1 1 1 1 Timeless protein DnaB PF00772.16 KII66978.1 - 0.027 14.3 3.0 0.068 13.0 0.2 2.9 3 0 0 3 3 3 0 DnaB-like helicase N terminal domain TMEM169 PF15052.1 KII66983.1 - 1.1 9.1 13.1 1.9 8.3 2.2 2.2 1 1 1 2 2 2 0 TMEM169 protein family EpuA PF11772.3 KII66983.1 - 3.5 7.1 9.8 0.26 10.7 2.4 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase subunit beta DUF2231 PF09990.4 KII66984.1 - 0.013 15.8 0.8 0.013 15.8 0.6 2.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2231) Transmemb_17 PF09799.4 KII66984.1 - 0.014 15.7 4.2 0.014 15.7 2.9 2.0 3 0 0 3 3 3 0 Predicted membrane protein DUF2705 PF10920.3 KII66984.1 - 0.057 12.6 8.9 0.014 14.6 3.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2705) LAB_N PF07578.6 KII66984.1 - 0.071 13.0 2.4 0.23 11.3 1.7 1.9 1 0 0 1 1 1 0 Lipid A Biosynthesis N-terminal domain EVI2A PF05399.6 KII66984.1 - 0.12 11.6 0.6 0.16 11.2 0.4 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DUF3784 PF12650.2 KII66984.1 - 3.3 7.7 11.6 1.9 8.4 3.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF3784) Claudin_2 PF13903.1 KII66984.1 - 9.4 5.8 11.8 19 4.8 8.2 1.8 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction ACR_tran PF00873.14 KII66985.1 - 0.035 11.5 1.6 0.041 11.3 1.1 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family DUF4013 PF13197.1 KII66985.1 - 2.3 7.5 22.4 0.12 11.6 10.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4013) Pex24p PF06398.6 KII66986.1 - 4.7 5.9 6.2 7.9 5.1 4.3 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin WRW PF10206.4 KII66988.1 - 0.024 14.6 0.5 0.036 14.1 0.1 1.5 2 0 0 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f DUF4064 PF13273.1 KII66988.1 - 0.04 14.0 3.9 0.11 12.5 2.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Sdh_cyt PF01127.17 KII66988.1 - 0.05 13.4 7.5 0.17 11.7 5.2 1.8 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Na_H_antiporter PF03553.9 KII66988.1 - 0.052 12.5 1.9 0.057 12.4 1.3 1.1 1 0 0 1 1 1 0 Na+/H+ antiporter family DUF3753 PF12575.3 KII66988.1 - 0.088 12.6 0.3 0.088 12.6 0.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) Chromate_transp PF02417.10 KII66988.1 - 0.089 12.3 3.7 0.33 10.5 0.4 2.1 2 0 0 2 2 2 0 Chromate transporter DUF3487 PF11990.3 KII66988.1 - 0.094 12.1 1.5 1.5 8.2 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3487) Rhomboid PF01694.17 KII66988.1 - 0.11 12.5 3.0 0.18 11.7 2.1 1.4 1 1 0 1 1 1 0 Rhomboid family zf-DHHC PF01529.15 KII66988.1 - 0.51 9.7 3.0 0.8 9.0 2.1 1.4 1 1 0 1 1 1 0 DHHC palmitoyltransferase PgpA PF04608.8 KII66988.1 - 0.53 10.0 3.1 1.1 9.1 2.2 1.5 1 1 0 1 1 1 0 Phosphatidylglycerophosphatase A SUR7 PF06687.7 KII66988.1 - 0.56 9.7 4.6 0.36 10.3 1.0 1.8 1 1 1 2 2 2 0 SUR7/PalI family DctQ PF04290.7 KII66988.1 - 1.4 8.7 7.1 2.7 7.7 4.9 1.5 1 1 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component YjgP_YjgQ PF03739.9 KII66988.1 - 2.5 6.7 7.6 1.3 7.7 0.4 2.0 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family DUF2975 PF11188.3 KII66988.1 - 4 7.1 7.1 65 3.2 4.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) DUF1600 PF07667.6 KII66988.1 - 4.1 7.5 8.2 3.7 7.6 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1600) Virul_fac_BrkB PF03631.10 KII66988.1 - 4.8 6.4 12.3 0.85 8.9 1.6 2.0 1 1 1 2 2 2 0 Virulence factor BrkB Gp49 PF05973.9 KII66989.1 - 0.15 12.1 0.1 0.15 12.1 0.1 1.6 2 0 0 2 2 2 0 Phage derived protein Gp49-like (DUF891) DUF3980 PF13140.1 KII66991.1 - 0.035 14.3 2.1 0.035 14.3 1.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3980) DUF1469 PF07332.6 KII66991.1 - 4.3 7.0 7.6 0.38 10.4 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DGC PF08859.6 KII66993.1 - 0.014 15.2 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 DGC domain DGC PF08859.6 KII66994.1 - 0.14 12.0 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 DGC domain Lamp PF01299.12 KII66995.1 - 0.047 12.8 0.2 0.051 12.7 0.1 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) IPK PF03770.11 KII66997.1 - 0.11 12.1 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Inositol polyphosphate kinase LPP20 PF02169.11 KII66997.1 - 0.11 12.5 1.3 0.14 12.2 0.9 1.2 1 0 0 1 1 1 0 LPP20 lipoprotein DUF768 PF05589.6 KII66997.1 - 0.41 10.6 1.8 8.5 6.3 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF768) MULE PF10551.4 KII66998.1 - 1e-09 38.3 1.0 1.9e-09 37.5 0.7 1.4 1 1 1 2 2 2 1 MULE transposase domain LysM PF01476.15 KII66999.1 - 7.2e-09 35.3 0.2 4.9e-08 32.7 0.0 2.2 2 0 0 2 2 2 1 LysM domain Flp_N PF03930.9 KII67000.1 - 0.058 13.1 1.1 0.11 12.2 0.8 1.5 1 0 0 1 1 1 0 Recombinase Flp protein N-terminus Salp15 PF12115.3 KII67003.1 - 0.048 13.8 0.2 0.32 11.2 0.0 1.9 1 1 1 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Glutaredoxin PF00462.19 KII67004.1 - 3e-17 62.3 0.1 5.6e-17 61.4 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.1 KII67004.1 - 3.5e-05 23.5 0.0 5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain DUF836 PF05768.9 KII67004.1 - 0.0068 16.6 0.1 0.0098 16.1 0.0 1.4 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) GST_N_3 PF13417.1 KII67004.1 - 0.0086 16.2 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain ArsC PF03960.10 KII67004.1 - 0.061 13.3 0.0 0.085 12.9 0.0 1.2 1 0 0 1 1 1 0 ArsC family PPO1_DWL PF12142.3 KII67004.1 - 0.09 12.3 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Polyphenol oxidase middle domain Tbf5 PF06331.7 KII67005.1 - 0.33 10.7 1.7 4.6 7.0 0.1 2.2 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 DUF1192 PF06698.6 KII67006.1 - 0.024 14.4 0.9 3 7.7 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) CD24 PF14984.1 KII67006.1 - 0.11 12.2 0.7 0.25 11.1 0.5 1.5 1 0 0 1 1 1 0 CD24 protein PT-HINT PF07591.6 KII67006.1 - 0.21 11.4 5.4 8.1 6.3 0.0 2.7 2 0 0 2 2 2 0 Pretoxin HINT domain GOLGA2L5 PF15070.1 KII67006.1 - 4.5 5.6 49.2 0.93 7.8 19.6 2.8 1 1 2 3 3 3 0 Putative golgin subfamily A member 2-like protein 5 TMF_DNA_bd PF12329.3 KII67006.1 - 8.7 6.2 49.5 0.12 12.2 4.3 5.9 4 2 2 6 6 6 0 TATA element modulatory factor 1 DNA binding AAA_22 PF13401.1 KII67007.1 - 8.1e-12 45.4 0.0 2e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KII67007.1 - 5e-07 29.6 1.8 1.7e-06 27.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KII67007.1 - 5.8e-07 29.7 0.0 1.9e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KII67007.1 - 6.8e-07 29.4 0.1 1e-05 25.5 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain NACHT PF05729.7 KII67007.1 - 2.2e-06 27.4 0.0 4.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_5 PF07728.9 KII67007.1 - 6.9e-05 22.5 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) NB-ARC PF00931.17 KII67007.1 - 0.00014 20.8 0.1 0.00028 19.8 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Cdc6_C PF09079.6 KII67007.1 - 0.0003 20.4 0.0 0.00088 18.9 0.0 1.8 2 0 0 2 2 1 1 CDC6, C terminal AAA_18 PF13238.1 KII67007.1 - 0.00086 19.6 0.6 0.0054 17.0 0.0 2.7 3 1 0 3 3 3 1 AAA domain DUF2075 PF09848.4 KII67007.1 - 0.0015 17.5 0.0 0.0015 17.5 0.0 1.5 2 0 0 2 2 1 1 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.1 KII67007.1 - 0.0025 18.6 0.0 0.0063 17.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KII67007.1 - 0.0037 16.8 0.7 0.0053 16.2 0.0 1.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 KII67007.1 - 0.004 16.9 0.3 0.004 16.9 0.2 2.9 3 1 1 4 4 4 1 Archaeal ATPase AAA_33 PF13671.1 KII67007.1 - 0.0042 16.9 0.1 0.012 15.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 KII67007.1 - 0.0043 17.0 0.1 0.039 14.0 0.1 2.5 1 1 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 KII67007.1 - 0.014 14.4 0.0 0.03 13.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin RNA12 PF10443.4 KII67007.1 - 0.02 13.4 0.0 0.02 13.4 0.0 2.3 3 0 0 3 3 3 0 RNA12 protein ATP_bind_1 PF03029.12 KII67007.1 - 0.023 14.2 0.0 0.046 13.2 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein SRPRB PF09439.5 KII67007.1 - 0.033 13.4 0.1 0.033 13.4 0.1 2.4 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit Sigma54_activat PF00158.21 KII67007.1 - 0.034 13.6 0.0 0.23 10.9 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain NTPase_1 PF03266.10 KII67007.1 - 0.056 13.1 0.0 0.2 11.3 0.0 1.9 1 1 1 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.13 KII67007.1 - 0.076 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family SMC_N PF02463.14 KII67007.1 - 0.095 11.9 1.5 3.6 6.7 0.0 2.5 2 1 1 3 3 2 0 RecF/RecN/SMC N terminal domain ATP-synt_ab PF00006.20 KII67007.1 - 0.099 12.1 0.0 0.25 10.7 0.0 1.7 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ALMT PF11744.3 KII67007.1 - 0.17 10.5 3.0 0.52 8.9 0.0 2.6 2 1 1 3 3 3 0 Aluminium activated malate transporter Serpin PF00079.15 KII67008.1 - 2.2e-20 73.1 0.6 2.6e-20 72.8 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_Tnp_IS1595 PF12762.2 KII67009.1 - 0.00016 21.5 0.0 0.00017 21.4 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Serpin PF00079.15 KII67011.1 - 2e-28 99.5 1.9 2.3e-28 99.4 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4230 PF14014.1 KII67011.1 - 0.082 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) Serpin PF00079.15 KII67012.1 - 1.8e-19 70.1 0.0 2e-19 69.9 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sugar_tr PF00083.19 KII67013.1 - 1.2e-24 86.7 15.9 1.5e-24 86.4 11.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Clc-like PF07062.7 KII67013.1 - 0.032 13.4 0.3 0.032 13.4 0.2 1.8 3 0 0 3 3 3 0 Clc-like Sugar_tr PF00083.19 KII67014.1 - 0.013 14.1 0.0 0.014 14.0 0.0 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter Serpin PF00079.15 KII67015.1 - 9.2e-58 196.1 9.9 1.6e-55 188.7 6.8 2.0 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) AOX PF01786.12 KII67018.1 - 0.062 12.7 0.0 0.1 11.9 0.0 1.4 2 0 0 2 2 2 0 Alternative oxidase Serpin PF00079.15 KII67019.1 - 1.6e-44 152.5 0.2 1.9e-44 152.3 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII67021.1 - 5.1e-13 48.9 0.0 5.6e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII67022.1 - 5.9e-39 134.2 3.6 6.7e-39 134.0 2.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3481 PF11980.3 KII67023.1 - 0.01 15.6 0.3 0.038 13.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3481) DUF1128 PF06569.6 KII67023.1 - 0.1 12.3 0.2 0.27 10.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1128) Glycos_trans_3N PF02885.12 KII67023.1 - 0.16 11.6 0.0 9.3 5.9 0.0 2.6 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain DUF3105 PF11303.3 KII67024.1 - 0.026 14.3 0.0 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3105) TPR_11 PF13414.1 KII67024.1 - 0.18 11.4 2.8 0.24 11.0 0.8 2.1 2 0 0 2 2 2 0 TPR repeat SNAP PF14938.1 KII67025.1 - 4.2e-10 39.2 1.0 5.3e-10 38.9 0.7 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII67025.1 - 0.018 14.7 2.4 0.018 14.7 1.7 2.3 2 1 0 2 2 2 0 TPR repeat TPR_1 PF00515.23 KII67025.1 - 0.059 13.0 12.5 0.45 10.2 0.3 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 KII67025.1 - 0.21 11.5 1.5 2.9 7.8 1.0 2.6 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII67025.1 - 0.56 10.2 10.9 3.3 7.8 0.1 4.5 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII67025.1 - 0.59 10.0 6.5 22 5.1 0.2 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat Lumazine_bd PF12870.2 KII67025.1 - 0.75 9.8 5.1 0.36 10.8 1.3 1.9 2 0 0 2 2 2 0 Lumazine-binding domain TPR_7 PF13176.1 KII67025.1 - 0.96 9.4 3.0 26 4.9 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat DDE_Tnp_IS1595 PF12762.2 KII67026.1 - 3.4e-17 62.6 0.2 1.1e-16 60.9 0.1 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF4371 PF14291.1 KII67030.1 - 3e-12 46.5 0.3 1e-11 44.8 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4371) Med9 PF07544.8 KII67030.1 - 1 9.1 4.7 1.2 8.9 0.0 3.0 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 PRESAN PF09687.5 KII67031.1 - 2.5 8.1 11.0 0.46 10.5 1.6 2.5 2 1 0 2 2 2 0 Plasmodium RESA N-terminal RVT_1 PF00078.22 KII67035.1 - 3.8e-21 75.4 0.3 1e-20 74.0 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII67035.1 - 3.9e-13 49.5 0.0 1.1e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII67035.1 - 7.1e-07 29.0 0.1 1.5e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII67035.1 - 0.00023 21.6 0.0 0.00048 20.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII67035.1 - 0.00068 19.4 3.3 0.00068 19.4 2.3 3.3 2 0 0 2 2 2 1 Zinc knuckle RVP_2 PF08284.6 KII67035.1 - 0.071 13.0 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII67035.1 - 0.092 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII67035.1 - 1.1 8.9 9.6 5.3 6.7 0.9 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 KII67035.1 - 1.8 8.3 10.0 65 3.3 6.9 2.6 1 1 0 1 1 1 0 Zinc knuckle DUF2004 PF09406.5 KII67036.1 - 0.087 12.8 0.6 0.32 11.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2004) Vezatin PF12632.2 KII67036.1 - 0.12 11.4 0.1 0.17 10.9 0.1 1.2 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes Ribosomal_S17 PF00366.15 KII67036.1 - 9.3 6.3 9.5 0.43 10.6 2.1 2.2 2 1 0 2 2 2 0 Ribosomal protein S17 SNAP PF14938.1 KII67042.1 - 2e-07 30.4 0.1 3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.23 KII67042.1 - 0.3 10.7 1.8 2.5 7.8 0.2 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII67042.1 - 0.53 9.9 3.6 1.6 8.4 1.6 2.4 2 1 1 3 3 3 0 TPR repeat HABP4_PAI-RBP1 PF04774.10 KII67044.1 - 1.3e-05 25.6 2.5 1.3e-05 25.6 1.8 3.4 3 1 0 3 3 3 1 Hyaluronan / mRNA binding family PROL5-SMR PF15621.1 KII67044.1 - 0.23 11.9 5.4 0.73 10.2 3.7 1.9 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family DUF2392 PF10288.4 KII67046.1 - 0.00045 20.5 0.1 0.00062 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) Asp_Glu_race PF01177.17 KII67046.1 - 0.00066 19.6 0.0 0.022 14.6 0.0 2.0 2 0 0 2 2 2 1 Asp/Glu/Hydantoin racemase Prok_Ub PF14454.1 KII67046.1 - 0.11 12.1 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 Prokaryotic Ubiquitin MmgE_PrpD PF03972.9 KII67046.1 - 0.12 10.5 0.0 0.16 10.1 0.0 1.1 1 0 0 1 1 1 0 MmgE/PrpD family DDE_3 PF13358.1 KII67047.1 - 0.075 12.7 1.5 0.15 11.7 0.8 1.7 1 1 1 2 2 2 0 DDE superfamily endonuclease DUF4393 PF14337.1 KII67048.1 - 0.27 10.6 4.7 0.91 8.9 3.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4393) SRP1_TIP1 PF00660.12 KII67049.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Seripauperin and TIP1 family TetR_C_8 PF14278.1 KII67050.1 - 0.098 13.0 0.5 0.098 13.0 0.3 2.1 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region CppA_C PF14507.1 KII67050.1 - 0.22 11.7 3.1 1.8 8.7 0.1 2.6 2 1 0 2 2 2 0 CppA C-terminal RRM_1 PF00076.17 KII67052.1 - 7.2e-17 60.7 0.0 2.1e-16 59.3 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII67052.1 - 1.6e-13 50.4 0.0 3e-13 49.5 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII67052.1 - 4.6e-10 39.2 0.0 5.9e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII67052.1 - 0.045 13.5 0.1 0.21 11.4 0.1 1.9 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif MscS_porin PF12795.2 KII67054.1 - 0.00053 19.3 6.4 0.00062 19.1 4.4 1.0 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain Mst1_SARAH PF11629.3 KII67054.1 - 0.0014 18.4 2.1 0.0034 17.1 0.0 2.6 1 1 2 3 3 3 1 C terminal SARAH domain of Mst1 DUF812 PF05667.6 KII67054.1 - 0.0014 17.2 4.8 0.0014 17.2 3.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Apolipoprotein PF01442.13 KII67054.1 - 0.0021 17.5 6.0 0.0028 17.1 4.1 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.10 KII67054.1 - 0.003 16.8 6.6 0.0033 16.6 4.6 1.0 1 0 0 1 1 1 1 Exonuclease VII, large subunit COG2 PF06148.6 KII67054.1 - 0.0047 16.8 2.9 0.008 16.0 2.0 1.5 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 IncA PF04156.9 KII67054.1 - 0.011 15.3 6.4 0.012 15.1 4.4 1.1 1 0 0 1 1 1 0 IncA protein DUF4298 PF14131.1 KII67054.1 - 0.024 14.4 4.0 0.034 14.0 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) Mnd1 PF03962.10 KII67054.1 - 0.028 14.0 5.8 0.042 13.5 4.0 1.2 1 0 0 1 1 1 0 Mnd1 family Sec8_exocyst PF04048.9 KII67054.1 - 0.037 13.6 5.4 0.044 13.4 3.7 1.1 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain CENP-F_leu_zip PF10473.4 KII67054.1 - 0.039 13.8 6.7 0.049 13.4 4.7 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.7 KII67054.1 - 0.039 13.7 0.7 0.063 13.0 0.5 1.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tropomyosin PF00261.15 KII67054.1 - 0.04 13.0 7.1 0.047 12.7 4.9 1.1 1 0 0 1 1 1 0 Tropomyosin Filament PF00038.16 KII67054.1 - 0.043 13.2 7.9 0.053 12.9 5.5 1.1 1 0 0 1 1 1 0 Intermediate filament protein Spc7 PF08317.6 KII67054.1 - 0.043 12.4 7.1 0.051 12.2 5.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Bacillus_HBL PF05791.6 KII67054.1 - 0.048 13.0 3.9 0.072 12.4 2.7 1.3 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Prominin PF05478.6 KII67054.1 - 0.05 11.1 4.6 0.053 11.0 3.2 1.0 1 0 0 1 1 1 0 Prominin ATG16 PF08614.6 KII67054.1 - 0.052 13.3 6.4 0.068 12.9 4.4 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Lectin_N PF03954.9 KII67054.1 - 0.056 12.8 1.0 0.069 12.5 0.7 1.1 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain BLOC1_2 PF10046.4 KII67054.1 - 0.065 13.3 4.1 0.1 12.7 2.8 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YscO PF07321.7 KII67054.1 - 0.071 12.9 6.8 0.14 12.0 4.7 1.5 1 1 0 1 1 1 0 Type III secretion protein YscO DUF2130 PF09903.4 KII67054.1 - 0.076 11.7 5.9 0.089 11.5 4.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) Atg14 PF10186.4 KII67054.1 - 0.081 11.8 6.8 0.096 11.6 4.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Syntaxin-6_N PF09177.6 KII67054.1 - 0.089 13.2 3.6 0.19 12.1 2.5 1.7 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF1978 PF09321.5 KII67054.1 - 0.096 12.1 6.7 0.12 11.8 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) HemX PF04375.9 KII67054.1 - 0.11 11.0 2.0 0.13 10.8 1.4 1.1 1 0 0 1 1 1 0 HemX AKNA PF12443.3 KII67054.1 - 0.12 12.4 2.9 0.16 11.9 2.0 1.5 1 1 0 1 1 1 0 AT-hook-containing transcription factor Rootletin PF15035.1 KII67054.1 - 0.12 12.3 8.6 0.15 12.0 5.9 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion IFT57 PF10498.4 KII67054.1 - 0.13 10.9 6.5 0.16 10.7 4.5 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF883 PF05957.8 KII67054.1 - 0.15 12.4 2.0 0.19 12.1 0.5 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF2663 PF10864.3 KII67054.1 - 0.16 12.1 4.3 0.28 11.4 3.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2663) DUF972 PF06156.8 KII67054.1 - 0.21 11.9 5.8 0.21 11.9 3.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF4337 PF14235.1 KII67054.1 - 0.27 11.0 8.8 0.34 10.7 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Spc24 PF08286.6 KII67054.1 - 0.27 10.9 4.2 0.29 10.8 2.3 1.5 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Macoilin PF09726.4 KII67054.1 - 0.34 9.1 6.8 0.38 8.9 4.7 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF4200 PF13863.1 KII67054.1 - 0.35 10.8 11.2 0.083 12.8 4.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Syntaxin_2 PF14523.1 KII67054.1 - 0.36 10.8 5.9 0.52 10.3 4.1 1.4 1 1 0 1 1 1 0 Syntaxin-like protein FlxA PF14282.1 KII67054.1 - 0.36 10.7 5.2 0.38 10.7 3.2 1.4 1 1 0 1 1 1 0 FlxA-like protein V_ATPase_I PF01496.14 KII67054.1 - 0.38 8.5 5.1 0.39 8.5 3.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TBPIP PF07106.8 KII67054.1 - 0.39 10.2 7.0 0.63 9.5 4.9 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TPR_MLP1_2 PF07926.7 KII67054.1 - 0.49 10.1 10.1 0.81 9.4 7.0 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Tup_N PF08581.5 KII67054.1 - 0.76 10.0 9.7 4.8 7.4 0.5 2.2 1 1 1 2 2 2 0 Tup N-terminal DUF745 PF05335.8 KII67054.1 - 0.86 9.0 5.5 1.1 8.7 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) ADIP PF11559.3 KII67054.1 - 0.89 9.4 10.2 1.2 9.0 7.1 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding USP8_interact PF08941.5 KII67054.1 - 1 8.6 3.7 0.57 9.4 1.2 1.5 2 0 0 2 2 2 0 USP8 interacting Prefoldin PF02996.12 KII67054.1 - 1.1 8.9 6.0 1.2 8.7 2.0 2.1 1 1 1 2 2 2 0 Prefoldin subunit APG6 PF04111.7 KII67054.1 - 1.4 7.9 9.4 1.5 7.7 6.5 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 Rho_Binding PF08912.6 KII67054.1 - 2.6 8.4 9.3 0.5 10.7 2.4 2.2 2 1 0 2 2 2 0 Rho Binding DUF342 PF03961.8 KII67054.1 - 3.1 6.1 6.2 3.5 5.9 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) YlqD PF11068.3 KII67054.1 - 3.1 7.8 8.2 5.4 7.0 5.7 1.4 1 1 0 1 1 1 0 YlqD protein Fzo_mitofusin PF04799.8 KII67054.1 - 3.3 7.0 7.3 12 5.2 5.0 1.7 1 1 0 1 1 1 0 fzo-like conserved region DUF904 PF06005.7 KII67054.1 - 5.8 7.2 8.9 17 5.8 6.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF904) bZIP_2 PF07716.10 KII67054.1 - 6 6.7 9.8 0.95 9.3 3.3 2.3 2 2 0 2 2 2 0 Basic region leucine zipper DUF3484 PF11983.3 KII67054.1 - 8.9 7.2 6.8 75 4.2 4.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3484) MM_CoA_mutase PF01642.17 KII67055.1 - 5e-58 196.5 0.1 6.5e-58 196.1 0.1 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase MM_CoA_mutase PF01642.17 KII67056.1 - 9.1e-50 169.2 0.2 1e-49 169.0 0.1 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.14 KII67057.1 - 4.1e-10 39.5 0.1 5e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 B12 binding domain FAM91_C PF14648.1 KII67058.1 - 0.076 11.8 1.4 0.094 11.5 1.0 1.0 1 0 0 1 1 1 0 FAM91 C-terminus Snapin_Pallidin PF14712.1 KII67058.1 - 0.11 12.8 7.1 0.29 11.4 4.9 1.8 1 1 0 1 1 1 0 Snapin/Pallidin DUF2968 PF11180.3 KII67058.1 - 0.69 9.2 7.9 0.95 8.8 5.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) AAA_23 PF13476.1 KII67058.1 - 1.9 8.7 14.3 2.6 8.3 9.9 1.1 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.4 KII67058.1 - 2 7.2 10.4 2.8 6.7 7.2 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Anemone_cytotox PF06369.7 KII67059.1 - 0.055 12.8 0.1 0.071 12.5 0.1 1.2 1 0 0 1 1 1 0 Sea anemone cytotoxic protein MRP-S24 PF14955.1 KII67060.1 - 5.8e-23 81.2 0.3 8.4e-23 80.7 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S24 FBA_3 PF08268.7 KII67060.1 - 0.036 13.8 0.2 0.057 13.1 0.1 1.4 1 0 0 1 1 1 0 F-box associated domain PRMT5 PF05185.11 KII67061.1 - 1.5e-106 356.9 1.3 3.8e-64 217.2 0.2 2.1 1 1 1 2 2 2 2 PRMT5 arginine-N-methyltransferase PIN_4 PF13638.1 KII67062.1 - 4.6e-10 39.7 0.1 7.7e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 PIN domain EST1_DNA_bind PF10373.4 KII67062.1 - 9.5e-05 21.7 8.9 0.00048 19.4 6.2 2.1 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain DUF3453 PF11935.3 KII67063.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3453) SseB_C PF14581.1 KII67064.1 - 0.002 17.9 0.4 0.0093 15.7 0.1 2.2 2 0 0 2 2 2 1 SseB protein C-terminal domain TBPIP PF07106.8 KII67064.1 - 0.01 15.4 9.6 0.58 9.6 2.2 2.3 2 0 0 2 2 2 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) MA3 PF02847.12 KII67064.1 - 0.015 14.9 0.8 0.04 13.6 0.5 1.7 1 0 0 1 1 1 0 MA3 domain Filament PF00038.16 KII67064.1 - 0.021 14.2 13.0 0.34 10.3 4.0 3.1 2 1 1 3 3 3 0 Intermediate filament protein Glucosaminidase PF01832.15 KII67064.1 - 0.059 13.4 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Reo_sigmaC PF04582.7 KII67064.1 - 0.073 12.2 2.0 1 8.4 0.2 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF719 PF05334.8 KII67064.1 - 0.086 12.8 0.4 7 6.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF719) IncA PF04156.9 KII67064.1 - 0.13 11.8 16.4 0.22 11.1 1.3 3.1 2 1 1 3 3 3 0 IncA protein Prefoldin PF02996.12 KII67064.1 - 0.14 11.8 6.2 2.5 7.7 0.2 3.4 3 0 0 3 3 3 0 Prefoldin subunit Jnk-SapK_ap_N PF09744.4 KII67064.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.0 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 Vir_act_alpha_C PF10400.4 KII67064.1 - 0.41 11.0 4.7 39 4.7 0.0 3.2 3 0 0 3 3 3 0 Virulence activator alpha C-term DivIVA PF05103.8 KII67064.1 - 0.42 10.6 8.2 0.56 10.2 1.9 2.4 2 0 0 2 2 2 0 DivIVA protein HeLo PF14479.1 KII67064.1 - 0.42 10.3 3.3 0.45 10.2 0.7 2.1 2 2 0 2 2 2 0 Prion-inhibition and propagation Cast PF10174.4 KII67064.1 - 0.54 8.2 8.9 0.071 11.1 2.8 1.7 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone Mnd1 PF03962.10 KII67064.1 - 0.65 9.6 11.4 0.59 9.7 1.5 2.5 2 1 0 2 2 2 0 Mnd1 family AKNA PF12443.3 KII67064.1 - 0.81 9.7 6.6 2.6 8.0 0.1 3.3 2 1 0 3 3 3 0 AT-hook-containing transcription factor DUF4200 PF13863.1 KII67064.1 - 2 8.3 11.3 0.81 9.6 0.3 3.3 2 1 0 3 3 3 0 Domain of unknown function (DUF4200) MutS_IV PF05190.13 KII67064.1 - 2.5 8.3 11.3 20 5.4 0.4 3.4 3 0 0 3 3 3 0 MutS family domain IV HALZ PF02183.13 KII67064.1 - 4 7.2 14.7 4.8 6.9 0.0 4.3 5 0 0 5 5 5 0 Homeobox associated leucine zipper SlyX PF04102.7 KII67064.1 - 5.5 7.4 6.1 12 6.3 0.3 3.3 3 1 1 4 4 3 0 SlyX Enkurin PF13864.1 KII67064.1 - 7 6.9 8.1 31 4.8 0.5 3.3 3 1 1 4 4 3 0 Calmodulin-binding zf-C3HC4_3 PF13920.1 KII67065.1 - 2.4e-07 30.3 10.3 5.2e-07 29.2 7.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII67065.1 - 7.1e-07 28.7 13.6 7.1e-07 28.7 9.4 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KII67065.1 - 1.5e-05 24.9 12.9 1.5e-05 24.9 9.0 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KII67065.1 - 0.00021 20.9 13.2 0.00057 19.5 9.2 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 KII67065.1 - 0.00041 20.1 11.4 0.0011 18.7 7.9 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 KII67065.1 - 0.016 14.9 6.4 0.046 13.4 4.4 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Rootletin PF15035.1 KII67065.1 - 0.12 12.3 12.3 0.43 10.5 8.6 1.7 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion zf-RING_6 PF14835.1 KII67065.1 - 0.13 12.0 4.2 0.27 11.0 2.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein PEPcase PF00311.12 KII67065.1 - 0.21 9.3 6.1 0.25 9.1 4.2 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase GTPase_Cys_C PF12631.2 KII67065.1 - 0.21 12.0 2.3 0.22 11.9 0.4 2.0 2 1 0 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE zf-RING_4 PF14570.1 KII67065.1 - 0.34 10.5 10.8 0.95 9.0 7.5 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 KII67065.1 - 0.68 9.8 4.9 1.3 8.9 3.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 KII67065.1 - 0.79 9.6 15.6 11 6.0 7.7 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-MIZ PF02891.15 KII67065.1 - 2.3 7.8 10.5 5.5 6.5 7.3 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Snapin_Pallidin PF14712.1 KII67065.1 - 3.6 7.9 9.7 0.88 9.9 2.6 2.2 1 1 1 2 2 2 0 Snapin/Pallidin AAA_32 PF13654.1 KII67065.1 - 5.4 5.5 9.2 6.3 5.3 6.4 1.1 1 0 0 1 1 1 0 AAA domain HTH_29 PF13551.1 KII67066.1 - 9e-09 35.4 0.0 1.2e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII67066.1 - 2.1e-07 30.3 0.1 0.0018 17.8 0.0 2.6 2 1 0 2 2 2 2 Homeodomain-like domain HTH_33 PF13592.1 KII67066.1 - 3.8e-06 26.3 0.1 6.3e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII67066.1 - 1.2e-05 25.1 0.0 0.16 12.0 0.0 2.3 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII67066.1 - 0.00011 22.1 0.4 0.00052 20.0 0.0 2.0 2 0 0 2 2 2 1 Transposase PAX PF00292.13 KII67066.1 - 0.00076 19.1 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_17 PF12728.2 KII67066.1 - 0.0011 19.1 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII67066.1 - 0.0014 18.2 0.4 0.0018 17.9 0.2 1.1 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII67066.1 - 0.0022 18.7 0.1 0.004 17.9 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain B5 PF03484.10 KII67066.1 - 0.0027 17.5 0.1 0.014 15.1 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetase B5 domain CENP-B_N PF04218.8 KII67066.1 - 0.0038 16.6 0.1 0.1 12.0 0.0 2.5 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.1 KII67066.1 - 0.006 15.9 0.0 0.078 12.3 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 KII67066.1 - 0.01 15.5 0.0 0.024 14.3 0.0 1.6 2 0 0 2 2 2 0 MarR family HTH_IclR PF09339.5 KII67066.1 - 0.013 15.0 0.0 0.2 11.2 0.0 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain ComX PF05952.7 KII67066.1 - 0.02 14.4 0.0 0.04 13.4 0.0 1.5 1 0 0 1 1 1 0 Bacillus competence pheromone ComX Sigma70_r4_2 PF08281.7 KII67066.1 - 0.022 14.2 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 DUF2470 PF10615.4 KII67066.1 - 0.03 14.5 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) TrmB PF01978.14 KII67066.1 - 0.096 12.4 0.0 0.61 9.8 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB NUMOD1 PF07453.8 KII67066.1 - 0.11 12.4 0.6 0.21 11.5 0.0 1.8 2 0 0 2 2 1 0 NUMOD1 domain Desmo_N PF06771.6 KII67066.1 - 0.14 12.0 2.8 0.53 10.2 1.7 2.0 2 1 1 3 3 3 0 Viral Desmoplakin N-terminus HTH_1 PF00126.22 KII67066.1 - 0.24 11.1 1.7 0.38 10.5 0.0 2.1 3 0 0 3 3 2 0 Bacterial regulatory helix-turn-helix protein, lysR family RRM_6 PF14259.1 KII67067.1 - 7.1e-33 112.4 0.1 2.7e-13 49.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII67067.1 - 5.3e-21 74.0 0.1 2.2e-08 33.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII67067.1 - 0.00066 19.4 0.1 0.12 12.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.1 KII67068.1 - 8.5e-05 22.1 3.7 8.5e-05 22.1 2.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII67068.1 - 0.009 15.6 2.4 0.009 15.6 1.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF2321 PF10083.4 KII67068.1 - 0.16 11.4 5.0 0.069 12.6 2.1 1.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) DZR PF12773.2 KII67068.1 - 0.23 11.3 5.6 0.49 10.2 3.9 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4_2 PF13923.1 KII67068.1 - 0.41 10.7 10.1 0.09 12.8 2.7 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_L37e PF01907.14 KII67068.1 - 0.67 9.7 2.6 0.43 10.4 0.5 1.6 2 0 0 2 2 2 0 Ribosomal protein L37e zf-C2H2 PF00096.21 KII67068.1 - 1.8 9.0 6.0 2.2 8.8 0.4 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type Cyclin_N PF00134.18 KII67069.1 - 1.3e-32 112.0 0.2 2.1e-32 111.3 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KII67069.1 - 4.8e-06 26.4 0.0 2.2e-05 24.3 0.0 2.2 1 1 0 1 1 1 1 Cyclin, C-terminal domain rve PF00665.21 KII67070.1 - 0.00067 19.7 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Kelch_3 PF13415.1 KII67072.1 - 7e-21 73.8 5.6 1.5e-06 28.1 0.0 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII67072.1 - 2.2e-20 72.1 8.3 3.9e-08 32.9 0.2 3.3 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII67072.1 - 1.6e-19 69.1 11.1 4.1e-06 26.2 2.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 KII67072.1 - 4.9e-18 64.4 11.9 5.8e-06 26.2 0.1 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII67072.1 - 1.3e-15 56.9 14.0 1.3e-07 31.4 0.5 3.6 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 KII67072.1 - 2.7e-06 26.8 4.8 0.0053 16.4 0.4 3.2 3 0 0 3 3 3 2 Kelch motif PDH PF02153.12 KII67076.1 - 0.048 12.5 0.2 0.073 11.9 0.2 1.2 1 0 0 1 1 1 0 Prephenate dehydrogenase DUF2524 PF10732.4 KII67076.1 - 0.14 12.3 1.9 0.25 11.4 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) RVT_1 PF00078.22 KII67079.1 - 1.7e-06 27.5 0.0 2.8e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-UBR PF02207.15 KII67081.1 - 5.5e-13 48.4 14.3 5.5e-13 48.4 9.9 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) HARP PF07443.8 KII67081.1 - 0.019 14.3 0.4 0.14 11.5 0.1 2.4 2 0 0 2 2 2 0 HepA-related protein (HARP) Kelch_6 PF13964.1 KII67083.1 - 3.9e-20 71.0 20.2 1.9e-05 24.6 0.4 5.4 4 1 1 5 5 5 5 Kelch motif Kelch_4 PF13418.1 KII67083.1 - 1.1e-18 66.6 21.0 7.8e-05 22.3 0.1 6.1 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII67083.1 - 4.2e-14 51.8 17.2 0.00072 19.0 0.8 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 KII67083.1 - 2.6e-13 49.7 11.6 0.034 14.3 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KII67083.1 - 2.3e-05 24.2 13.6 0.073 13.0 0.3 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 KII67083.1 - 0.00086 18.9 15.1 0.7 9.7 0.1 5.4 5 1 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 KII67085.1 - 1e-17 63.4 8.9 3.2e-07 30.2 0.8 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII67085.1 - 3.9e-17 61.5 7.9 6.8e-08 31.9 0.3 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII67085.1 - 2.5e-15 55.9 7.0 7.8e-05 22.3 0.1 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII67085.1 - 1.5e-14 53.6 3.3 0.00016 21.7 0.1 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII67085.1 - 1.2e-06 28.3 6.4 0.0035 17.2 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII67085.1 - 8.1e-05 22.2 8.7 0.001 18.7 0.1 3.4 3 1 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 KII67086.1 - 1.7e-05 24.4 5.0 0.00011 21.9 0.1 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.1 KII67086.1 - 0.00093 19.3 2.1 0.0064 16.6 0.2 2.7 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII67086.1 - 0.0087 16.1 2.3 0.0097 16.0 0.1 2.2 2 1 1 3 3 3 1 Kelch motif Kelch_5 PF13854.1 KII67086.1 - 0.018 14.9 1.7 0.32 11.0 0.1 2.5 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.20 KII67086.1 - 0.02 14.4 3.6 0.33 10.5 0.1 2.4 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 KII67087.1 - 3.5e-23 80.7 19.0 7.5e-06 25.9 0.6 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 KII67087.1 - 4.2e-17 61.7 13.8 0.0008 19.5 0.2 5.6 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII67087.1 - 1.4e-16 59.7 16.0 4.3e-06 26.1 0.7 5.8 5 1 0 5 5 5 4 Kelch motif Kelch_4 PF13418.1 KII67087.1 - 1.4e-10 40.7 26.7 0.00015 21.4 0.2 6.0 4 2 2 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII67087.1 - 4.2e-05 23.3 15.5 0.0026 17.6 0.4 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 KII67087.1 - 0.012 15.3 22.7 1.8 8.4 0.2 6.1 5 2 1 6 6 6 0 Kelch motif PQQ_3 PF13570.1 KII67087.1 - 0.089 13.1 2.2 7.5 6.9 0.1 3.6 3 0 0 3 3 3 0 PQQ-like domain Ldl_recept_a PF00057.13 KII67089.1 - 0.0011 18.8 6.0 0.0011 18.8 4.1 3.9 4 0 0 4 4 4 2 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII67089.1 - 0.018 14.7 3.6 7.6 6.8 0.0 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat ArfGap PF01412.13 KII67091.1 - 0.0085 15.8 1.4 0.029 14.1 0.2 2.3 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf OSTMP1 PF09777.4 KII67091.1 - 0.16 11.1 10.2 0.27 10.3 5.9 1.9 2 0 0 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor Rcd1 PF04078.8 KII67093.1 - 0.11 11.2 0.1 0.15 10.8 0.1 1.3 1 1 0 1 1 1 0 Cell differentiation family, Rcd1-like BNR PF02012.15 KII67095.1 - 1.9e-06 26.8 1.7 0.33 10.9 0.1 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat rve PF00665.21 KII67098.1 - 2.1e-26 92.3 0.0 2.7e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII67098.1 - 0.00013 21.3 0.1 0.00025 20.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII67098.1 - 0.016 15.2 0.1 0.033 14.1 0.0 1.5 2 0 0 2 2 2 0 DDE domain Serpin PF00079.15 KII67102.1 - 2.2e-29 102.7 3.0 2.4e-29 102.6 2.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RVP PF00077.15 KII67103.1 - 1.2e-05 25.1 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII67103.1 - 0.08 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease AT_hook PF02178.14 KII67106.1 - 2.6 8.0 9.5 0.16 11.7 1.0 2.6 2 0 0 2 2 2 0 AT hook motif DDE_1 PF03184.14 KII67108.1 - 0.029 13.4 0.3 0.039 13.1 0.2 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease PDEase_II PF02112.10 KII67111.1 - 0.072 12.0 0.0 0.088 11.7 0.0 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II DUF4416 PF14385.1 KII67115.1 - 0.046 13.4 0.4 0.061 13.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4416) Zip PF02535.17 KII67116.1 - 2.7e-56 190.9 15.6 4.2e-56 190.2 10.8 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter PXA PF02194.10 KII67118.1 - 2.2e-16 59.9 0.9 6.5e-16 58.4 0.6 1.8 1 0 0 1 1 1 1 PXA domain PX PF00787.19 KII67118.1 - 3.4e-11 42.9 6.7 1e-10 41.3 4.6 1.9 1 0 0 1 1 1 1 PX domain SNARE_assoc PF09335.6 KII67119.1 - 4.4e-15 55.9 5.9 4.4e-15 55.9 4.1 2.1 1 1 1 2 2 2 1 SNARE associated Golgi protein Chordopox_A13L PF05961.6 KII67119.1 - 0.25 11.3 3.1 0.2 11.6 0.4 2.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein TctB PF07331.6 KII67119.1 - 5.5 6.6 14.7 0.091 12.4 3.3 2.3 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Ribosomal_S20p PF01649.13 KII67120.1 - 0.016 15.5 0.3 0.057 13.7 0.2 1.9 1 0 0 1 1 1 0 Ribosomal protein S20 Xpo1 PF08389.7 KII67122.1 - 0.032 14.1 0.1 0.072 13.0 0.0 1.6 1 1 1 2 2 2 0 Exportin 1-like protein P_proprotein PF01483.15 KII67123.1 - 0.016 14.9 0.3 0.055 13.2 0.0 2.0 2 1 0 2 2 2 0 Proprotein convertase P-domain HTH_29 PF13551.1 KII67124.1 - 0.052 13.7 0.0 0.076 13.1 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn helix rve PF00665.21 KII67125.1 - 1.6e-24 86.3 0.0 3.3e-24 85.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII67125.1 - 4.5e-17 62.1 0.0 1.2e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII67125.1 - 0.00017 21.0 0.0 0.00041 19.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII67125.1 - 0.0018 18.1 0.0 0.014 15.2 0.0 2.3 2 0 0 2 2 2 1 Retroviral aspartyl protease Retrotrans_gag PF03732.12 KII67125.1 - 0.0029 17.6 1.8 0.028 14.4 0.0 2.9 3 0 0 3 3 3 1 Retrotransposon gag protein zf-CCHC PF00098.18 KII67125.1 - 0.02 14.7 11.8 0.083 12.8 3.0 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII67125.1 - 0.069 12.8 10.4 0.33 10.6 0.7 2.9 2 0 0 2 2 2 0 Zinc knuckle Haemagg_act PF05860.8 KII67126.1 - 1.5e-33 115.1 6.0 1.5e-33 115.1 4.2 4.3 4 1 0 4 4 4 1 haemagglutination activity domain UPF0016 PF01169.14 KII67127.1 - 4e-17 62.1 5.4 5.7e-17 61.6 3.7 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0016 FTR1 PF03239.9 KII67127.1 - 0.00028 19.9 0.8 0.00037 19.5 0.5 1.1 1 0 0 1 1 1 1 Iron permease FTR1 family NDUF_B7 PF05676.8 KII67127.1 - 0.082 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DDE_Tnp_IS1595 PF12762.2 KII67128.1 - 0.00066 19.5 0.0 0.00073 19.3 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain RNase_T PF00929.19 KII67129.1 - 6.4e-23 81.8 0.1 7.5e-23 81.6 0.0 1.0 1 0 0 1 1 1 1 Exonuclease DUF382 PF04037.8 KII67131.1 - 3.7e-56 188.4 0.9 3.7e-56 188.4 0.7 2.2 2 1 1 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.11 KII67131.1 - 1.1e-21 75.8 3.2 2.5e-21 74.7 2.2 1.6 1 0 0 1 1 1 1 PSP Birna_VP4 PF01768.11 KII67131.1 - 0.092 11.7 0.1 0.17 10.9 0.1 1.4 1 0 0 1 1 1 0 Birnavirus VP4 protein CTD_bind PF04818.8 KII67132.1 - 1.5e-05 25.1 0.3 1.5e-05 25.1 0.2 2.7 3 0 0 3 3 3 1 RNA polymerase II-binding domain. DUF976 PF06162.7 KII67132.1 - 0.056 12.9 1.8 0.34 10.4 0.4 2.5 1 1 1 2 2 2 0 Caenorhabditis elegans protein of unknown function (DUF976) Rap_GAP PF02145.10 KII67135.1 - 9.4e-44 149.0 0.0 5e-43 146.6 0.0 2.3 2 0 0 2 2 2 1 Rap/ran-GAP adh_short PF00106.20 KII67137.1 - 6.9e-08 32.5 0.0 1.1e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 KII67137.1 - 0.0016 18.4 0.0 0.0024 17.8 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 KII67137.1 - 0.005 16.5 0.0 0.0079 15.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Glyco_tran_WecB PF03808.8 KII67137.1 - 0.054 12.8 0.0 0.088 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family adh_short_C2 PF13561.1 KII67137.1 - 0.07 12.8 0.1 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 KII67138.1 - 1.5e-06 28.1 0.0 4e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 KII67138.1 - 0.02 13.7 0.1 0.033 13.0 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Ribosomal_L12 PF00542.14 KII67138.1 - 0.024 14.6 0.9 0.05 13.6 0.6 1.5 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain Glyco_tran_WecB PF03808.8 KII67138.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family RNA_pol_Rpb4 PF03874.11 KII67139.1 - 0.002 18.1 0.9 0.0067 16.4 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb4 AAA PF00004.24 KII67140.1 - 1.5e-13 51.0 0.0 3e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 KII67140.1 - 8.1e-13 48.3 0.0 1.3e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 KII67140.1 - 1.3e-09 37.9 0.1 3.8e-09 36.4 0.0 1.8 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_22 PF13401.1 KII67140.1 - 9e-08 32.3 0.1 5.5e-07 29.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 KII67140.1 - 3.9e-06 26.5 0.0 7.2e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 KII67140.1 - 5.9e-06 25.2 0.0 0.00068 18.4 0.0 2.2 1 1 1 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 KII67140.1 - 9e-06 25.7 0.0 0.0051 16.8 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 KII67140.1 - 3.5e-05 23.7 0.0 7.5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII67140.1 - 4.5e-05 23.1 0.0 9.8e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_24 PF13479.1 KII67140.1 - 0.00026 20.6 0.0 0.00045 19.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 KII67140.1 - 0.00056 19.4 0.6 0.13 11.7 0.0 3.2 2 1 1 3 3 3 1 DEAD/DEAH box helicase AAA_11 PF13086.1 KII67140.1 - 0.00081 19.0 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KII67140.1 - 0.0011 18.7 0.1 0.0029 17.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 KII67140.1 - 0.0015 18.0 0.1 1.4 8.2 0.0 2.3 1 1 1 2 2 2 2 AAA-like domain DUF2075 PF09848.4 KII67140.1 - 0.0032 16.5 0.0 0.0047 15.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.11 KII67140.1 - 0.0058 15.8 0.0 3.6 6.7 0.0 2.3 1 1 1 2 2 2 2 PhoH-like protein DUF815 PF05673.8 KII67140.1 - 0.017 14.0 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 KII67140.1 - 0.018 14.2 0.1 0.12 11.5 0.1 2.3 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KII67140.1 - 0.018 14.4 0.0 0.044 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 KII67140.1 - 0.019 14.3 0.0 0.14 11.5 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein Zot PF05707.7 KII67140.1 - 0.024 14.1 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) RuvB_N PF05496.7 KII67140.1 - 0.055 12.4 0.0 0.18 10.8 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 KII67140.1 - 0.06 13.5 0.0 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 KII67140.1 - 0.08 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain DNA_pol3_gamma3 PF12169.3 KII67140.1 - 0.09 12.5 0.0 0.19 11.4 0.0 1.6 1 1 0 1 1 1 0 DNA polymerase III subunits gamma and tau domain III YafO_toxin PF13957.1 KII67141.1 - 0.076 12.8 0.2 0.13 12.0 0.0 1.4 2 0 0 2 2 2 0 Toxin YafO, type II toxin-antitoxin system Helicase_C PF00271.26 KII67144.1 - 6.4e-19 67.6 0.0 3e-17 62.2 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KII67144.1 - 4.2e-18 65.3 0.0 1.7e-17 63.4 0.0 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase RQC PF09382.5 KII67144.1 - 3e-17 62.2 0.0 7.2e-17 61.0 0.0 1.6 1 0 0 1 1 1 1 RQC domain HRDC PF00570.18 KII67144.1 - 0.00035 20.2 0.0 0.00084 19.0 0.0 1.7 1 0 0 1 1 1 1 HRDC domain DUF3760 PF12586.3 KII67144.1 - 0.039 13.7 0.9 0.28 11.0 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) Ribosomal_L22e PF01776.12 KII67145.1 - 0.053 13.5 5.1 0.92 9.5 0.1 2.4 2 0 0 2 2 2 0 Ribosomal L22e protein family DDE_3 PF13358.1 KII67146.1 - 6.9e-06 25.8 0.0 1.3e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII67146.1 - 0.0035 17.3 0.1 0.01 15.8 0.1 1.9 1 1 0 1 1 1 1 Transposase HTH_23 PF13384.1 KII67146.1 - 0.065 12.9 0.6 3.3 7.4 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain HSL_N PF06350.7 KII67147.1 - 2.6e-06 26.7 0.1 3.1e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus Neisseria_TspB PF05616.8 KII67147.1 - 0.055 11.8 0.1 0.059 11.7 0.1 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Ribosomal_L27e PF01777.13 KII67147.1 - 0.066 13.3 0.1 0.17 12.0 0.0 1.7 2 0 0 2 2 2 0 Ribosomal L27e protein family Abhydrolase_3 PF07859.8 KII67148.1 - 9.7e-39 133.1 0.0 2.7e-27 95.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF2424 PF10340.4 KII67148.1 - 6.5e-10 38.1 0.0 9.2e-10 37.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) HSL_N PF06350.7 KII67148.1 - 1.2e-06 27.8 0.0 2.1e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus CDC27 PF09507.5 KII67149.1 - 0.0067 15.6 1.7 0.0067 15.6 1.2 2.0 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 Mitofilin PF09731.4 KII67149.1 - 0.057 12.0 3.2 0.066 11.8 2.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CUE PF02845.11 KII67151.1 - 0.00036 19.9 0.0 0.001 18.4 0.0 1.7 1 0 0 1 1 1 1 CUE domain HSP20 PF00011.16 KII67152.1 - 2e-13 50.0 0.0 2.7e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Fis1_TPR_C PF14853.1 KII67153.1 - 3.4e-08 33.2 0.2 6.1e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.12 KII67153.1 - 0.00043 19.9 1.2 0.00073 19.2 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII67153.1 - 0.0038 16.7 0.1 0.0082 15.7 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_N PF14852.1 KII67153.1 - 0.011 15.0 0.1 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat TPR_11 PF13414.1 KII67153.1 - 0.011 15.3 0.3 0.028 14.0 0.0 1.7 2 0 0 2 2 2 0 TPR repeat Apc3 PF12895.2 KII67153.1 - 0.019 15.0 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KII67153.1 - 0.024 15.2 0.2 0.21 12.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-SNAP50_C PF12251.3 KII67153.1 - 0.052 12.9 0.0 0.081 12.2 0.0 1.2 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal NARP1 PF12569.3 KII67153.1 - 0.053 12.2 0.0 0.067 11.9 0.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_16 PF13432.1 KII67153.1 - 0.079 13.6 0.3 0.43 11.3 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.1 KII67153.1 - 0.11 11.5 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.1 KII67153.1 - 0.13 12.1 0.3 1.7 8.5 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Syndecan PF01034.15 KII67153.1 - 0.2 11.3 0.6 2.9 7.6 0.1 2.2 2 0 0 2 2 2 0 Syndecan domain EMP70 PF02990.11 KII67155.1 - 7.8e-79 265.5 30.3 8.7e-78 262.0 21.0 2.0 1 1 0 1 1 1 1 Endomembrane protein 70 MgtC PF02308.11 KII67155.1 - 1.1 9.0 6.7 0.39 10.5 1.0 2.5 2 0 0 2 2 2 0 MgtC family UbiA PF01040.13 KII67158.1 - 4.1e-31 108.1 18.3 5.1e-31 107.8 12.7 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Pkinase PF00069.20 KII67159.1 - 4.2e-47 160.4 0.0 7e-47 159.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII67159.1 - 1.8e-19 69.8 0.1 3.4e-19 68.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII67159.1 - 0.078 11.9 0.0 0.16 10.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like HTH_Tnp_Tc3_2 PF01498.13 KII67162.1 - 2.1e-06 27.6 0.0 3.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Transposase SAM_decarbox PF01536.11 KII67162.1 - 0.027 13.1 0.2 0.035 12.7 0.1 1.2 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase JmjN PF02375.12 KII67162.1 - 0.028 13.9 0.0 0.087 12.3 0.0 1.9 1 0 0 1 1 1 0 jmjN domain Phage_int_SAM_5 PF13102.1 KII67163.1 - 0.083 12.8 1.6 0.12 12.3 1.0 1.4 1 1 0 1 1 1 0 Phage integrase SAM-like domain DUF3596 PF12167.3 KII67163.1 - 0.11 12.0 0.2 0.28 10.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3596) FAD_binding_3 PF01494.14 KII67164.1 - 1.4e-17 63.8 0.0 1e-08 34.6 0.0 2.4 3 0 0 3 3 3 2 FAD binding domain SE PF08491.5 KII67164.1 - 0.00019 20.3 0.3 0.00048 19.0 0.0 1.7 2 0 0 2 2 2 1 Squalene epoxidase Lycopene_cycl PF05834.7 KII67164.1 - 0.0042 16.0 0.0 0.0055 15.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.9 KII67164.1 - 0.095 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase AA_permease_2 PF13520.1 KII67165.1 - 1.3e-48 165.5 55.5 1.7e-48 165.2 38.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII67165.1 - 7.7e-20 70.6 48.7 9.6e-20 70.3 33.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KII67166.1 - 1.8e-46 158.5 53.6 2.1e-46 158.3 37.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII67166.1 - 1.7e-19 69.5 45.7 2.1e-19 69.2 31.6 1.0 1 0 0 1 1 1 1 Amino acid permease zf-HC5HC2H_2 PF13832.1 KII67168.1 - 8.1e-05 22.5 3.2 9.3e-05 22.3 2.2 1.2 1 0 0 1 1 1 1 PHD-zinc-finger like domain C1_1 PF00130.17 KII67168.1 - 0.00027 20.5 3.3 0.00027 20.5 2.3 2.0 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 KII67168.1 - 0.0048 16.5 3.6 0.0048 16.5 2.5 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-HC5HC2H PF13771.1 KII67168.1 - 0.0068 16.5 4.1 0.0085 16.2 2.9 1.3 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-C4pol PF14260.1 KII67168.1 - 0.06 13.3 1.7 0.06 13.3 1.2 2.0 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta FANCL_C PF11793.3 KII67168.1 - 0.07 13.1 8.0 0.095 12.6 5.6 1.3 1 0 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.24 KII67168.1 - 0.41 10.3 10.5 0.7 9.6 6.5 1.9 1 1 1 2 2 2 0 PHD-finger DBD_Tnp_Mut PF03108.10 KII67168.1 - 0.6 9.7 3.8 0.9 9.1 2.6 1.2 1 0 0 1 1 1 0 MuDR family transposase zf-RING_2 PF13639.1 KII67168.1 - 0.66 9.8 9.0 1.2 9.0 6.2 1.6 1 1 0 1 1 1 0 Ring finger domain GF_recep_IV PF14843.1 KII67168.1 - 0.74 9.4 8.2 5.1 6.7 5.9 1.8 1 1 1 2 2 2 0 Growth factor receptor domain IV Transp_Tc5_C PF04236.10 KII67168.1 - 2.8 8.2 6.8 6 7.1 0.1 2.4 1 1 1 2 2 2 0 Tc5 transposase C-terminal domain FYVE PF01363.16 KII67168.1 - 8.5 6.3 9.1 17 5.4 6.2 1.5 1 1 0 1 1 1 0 FYVE zinc finger zf-C2HC5 PF06221.8 KII67168.1 - 9.6 6.0 10.6 0.25 11.1 0.6 2.6 1 1 2 3 3 3 0 Putative zinc finger motif, C2HC5-type Corona_6B_7B PF03262.8 KII67169.1 - 0.041 13.1 0.0 0.05 12.8 0.0 1.1 1 0 0 1 1 1 0 Coronavirus 6B/7B protein Adaptin_N PF01602.15 KII67171.1 - 1.9e-131 439.0 21.1 2.5e-131 438.6 14.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 KII67171.1 - 2.4e-20 73.1 3.3 2.4e-20 73.1 2.3 2.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 KII67171.1 - 4.3e-13 49.3 0.2 8.2e-05 22.8 0.0 4.5 2 2 1 4 4 4 3 HEAT repeats HEAT PF02985.17 KII67171.1 - 5.7e-09 35.3 3.3 0.0028 17.6 0.0 5.6 6 0 0 6 6 5 2 HEAT repeat DNA_alkylation PF08713.6 KII67171.1 - 0.0013 18.2 0.1 0.0038 16.7 0.0 1.8 2 0 0 2 2 2 1 DNA alkylation repair enzyme HEAT_EZ PF13513.1 KII67171.1 - 0.0022 18.4 0.7 1.9 9.0 0.0 4.8 5 1 1 6 6 6 1 HEAT-like repeat AP4E_app_platf PF14807.1 KII67171.1 - 0.0023 18.1 0.1 0.0097 16.1 0.0 2.2 2 0 0 2 2 2 1 Adaptin AP4 complex epsilon appendage platform CLASP_N PF12348.3 KII67171.1 - 0.0073 15.6 4.4 0.49 9.6 0.0 4.3 3 1 1 4 4 4 1 CLASP N terminal Arm PF00514.18 KII67171.1 - 0.028 14.2 3.5 4.5 7.2 0.0 4.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat B2-adapt-app_C PF09066.5 KII67171.1 - 0.05 13.4 1.5 0.1 12.4 0.1 2.3 3 0 0 3 3 3 0 Beta2-adaptin appendage, C-terminal sub-domain IATP PF04568.7 KII67171.1 - 0.075 13.0 2.0 0.15 12.1 1.4 1.5 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP TM2 PF05154.11 KII67172.1 - 0.0017 18.5 3.2 0.0017 18.5 2.2 1.7 2 0 0 2 2 2 1 TM2 domain DUF4477 PF14780.1 KII67174.1 - 0.014 14.7 2.5 3.1 7.1 1.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4477) DUF3951 PF13131.1 KII67175.1 - 0.071 12.8 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) G_glu_transpept PF01019.16 KII67176.1 - 2e-109 366.3 0.0 8.3e-64 215.9 0.0 2.7 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase LysM PF01476.15 KII67177.1 - 0.038 13.8 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 LysM domain Citrate_ly_lig PF08218.6 KII67177.1 - 0.054 12.9 0.0 0.063 12.7 0.0 1.1 1 0 0 1 1 1 0 Citrate lyase ligase C-terminal domain Exo_endo_phos PF03372.18 KII67178.1 - 3.4e-08 33.7 0.0 5.1e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KII67178.1 - 0.00014 21.4 0.1 0.00082 18.9 0.1 2.1 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase DUF663 PF04950.7 KII67179.1 - 6.5e-34 117.2 1.5 3.8e-23 81.8 0.1 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF663) AARP2CN PF08142.7 KII67180.1 - 8e-08 31.7 0.0 2.1e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain HTH_Tnp_Tc3_2 PF01498.13 KII67181.1 - 7.4e-05 22.7 0.0 0.00058 19.8 0.0 2.2 2 1 0 2 2 2 1 Transposase HTH_29 PF13551.1 KII67181.1 - 0.00046 20.3 0.0 0.00078 19.5 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII67181.1 - 0.0023 18.6 0.0 0.0075 17.0 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_21 PF13276.1 KII67181.1 - 0.0026 17.7 0.0 1.6 8.7 0.0 2.4 2 0 0 2 2 2 2 HTH-like domain HTH_23 PF13384.1 KII67181.1 - 0.03 13.9 0.2 0.64 9.7 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain Abhydrolase_1 PF00561.15 KII67182.1 - 1.3e-12 47.7 0.0 8.1e-11 41.9 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KII67182.1 - 9e-12 45.3 0.0 1.6e-11 44.5 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KII67182.1 - 2.2e-07 30.7 0.0 6.1e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2305 PF10230.4 KII67182.1 - 0.0019 17.6 0.1 0.0037 16.7 0.1 1.4 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Peptidase_S9 PF00326.16 KII67182.1 - 0.11 11.7 0.0 10 5.3 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydro_lipase PF04083.11 KII67183.1 - 7.4e-09 34.8 0.0 1.5e-08 33.8 0.0 1.5 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region DUF1138 PF06592.8 KII67184.1 - 0.029 14.3 0.0 8.2 6.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1138) DDE_3 PF13358.1 KII67184.1 - 0.079 12.7 0.2 2.6 7.8 0.0 2.7 2 1 1 3 3 3 0 DDE superfamily endonuclease NUDIX PF00293.23 KII67185.1 - 8.6e-14 51.3 0.0 1e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Foie-gras_1 PF11817.3 KII67186.1 - 0.00014 21.4 0.1 0.00028 20.4 0.0 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 SCO1-SenC PF02630.9 KII67187.1 - 1.3e-13 50.9 0.1 1.6e-13 50.6 0.1 1.1 1 0 0 1 1 1 1 SCO1/SenC IU_nuc_hydro PF01156.14 KII67188.1 - 4.1e-46 157.6 0.0 4.8e-46 157.4 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase IU_nuc_hydro PF01156.14 KII67189.1 - 3.1e-20 72.6 0.0 3.5e-20 72.4 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase ETC_C1_NDUFA4 PF04800.7 KII67190.1 - 7.3e-29 99.6 1.4 9.7e-29 99.2 1.0 1.1 1 0 0 1 1 1 1 ETC complex I subunit conserved region Guanylate_kin PF00625.16 KII67191.1 - 2.2e-05 23.9 0.0 3.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Guanylate kinase Kelch_6 PF13964.1 KII67192.1 - 1.4e-10 40.8 3.0 0.0069 16.5 0.0 4.9 3 2 2 5 5 5 3 Kelch motif Kelch_2 PF07646.10 KII67192.1 - 6.2e-06 25.7 1.0 1.5 8.6 0.0 3.7 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 KII67192.1 - 2.2e-05 23.8 1.4 0.21 11.1 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 KII67192.1 - 0.029 14.1 1.5 26 4.6 0.0 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.1 KII67192.1 - 0.13 12.2 2.4 15 5.6 0.0 3.3 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.20 KII67193.1 - 3.6e-13 48.8 4.8 3.1e-06 26.6 0.0 3.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.1 KII67193.1 - 3.7e-13 49.0 0.3 5.5e-07 29.2 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.1 KII67193.1 - 5.4e-13 48.5 2.5 4.3e-05 23.4 0.2 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII67193.1 - 1.6e-11 43.9 5.6 3.3e-07 30.0 0.0 3.4 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 KII67193.1 - 7.5e-05 22.7 0.0 0.52 10.5 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII67193.1 - 0.00015 21.4 2.0 0.066 13.0 0.0 3.0 3 0 0 3 3 3 2 Kelch motif MULE PF10551.4 KII67194.1 - 1.2e-09 38.1 0.0 2.9e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Kelch_5 PF13854.1 KII67195.1 - 1.5e-11 43.9 10.5 1.9e-05 24.4 0.0 6.0 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.1 KII67195.1 - 3.6e-10 39.5 21.1 0.011 15.8 0.1 6.4 4 2 2 6 6 6 4 Kelch motif Kelch_4 PF13418.1 KII67195.1 - 7.7e-08 31.9 18.4 4.2e-06 26.4 0.0 7.0 7 1 1 8 8 8 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII67195.1 - 1.6e-06 28.1 5.4 1.3 9.2 0.0 6.4 6 1 0 6 6 6 1 Galactose oxidase, central domain Kelch_1 PF01344.20 KII67195.1 - 6.1e-06 25.6 17.9 4.8e-05 22.8 0.2 5.5 6 1 0 6 6 6 2 Kelch motif Kelch_2 PF07646.10 KII67195.1 - 0.0065 16.1 18.6 0.72 9.7 0.1 6.9 6 3 1 7 7 7 2 Kelch motif Kelch_1 PF01344.20 KII67196.1 - 9.5e-18 63.4 17.8 2.2e-05 23.9 1.8 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.1 KII67196.1 - 3.1e-15 55.6 7.9 0.00026 21.0 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 KII67196.1 - 3.6e-12 45.8 8.3 1.7e-05 24.5 0.4 4.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII67196.1 - 1.4e-11 44.0 9.1 0.00022 21.0 0.4 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.10 KII67196.1 - 7.5e-09 35.0 9.4 0.017 14.8 0.3 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 KII67196.1 - 2.2e-05 24.4 8.9 0.12 12.5 0.0 4.6 4 1 0 4 4 4 2 Galactose oxidase, central domain Peptidase_M66 PF10462.4 KII67196.1 - 0.13 11.0 0.4 3.5 6.3 0.0 2.1 2 0 0 2 2 2 0 Peptidase M66 RVT_1 PF00078.22 KII67197.1 - 0.012 14.9 0.2 0.88 8.8 0.0 2.3 1 1 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Catalase-rel PF06628.7 KII67197.1 - 0.058 13.2 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 Catalase-related immune-responsive Pmp3 PF01679.12 KII67198.1 - 0.06 13.0 1.7 0.18 11.5 0.2 2.2 2 0 0 2 2 2 0 Proteolipid membrane potential modulator Seipin PF06775.9 KII67198.1 - 0.1 12.1 0.0 0.18 11.2 0.0 1.5 2 0 0 2 2 2 0 Putative adipose-regulatory protein (Seipin) Integrin_beta PF00362.13 KII67199.1 - 2.8e-23 82.5 4.9 3.8e-23 82.0 3.4 1.2 1 0 0 1 1 1 1 Integrin, beta chain EGF_2 PF07974.8 KII67199.1 - 0.032 14.4 12.4 0.032 14.4 8.6 2.9 1 1 1 2 2 2 0 EGF-like domain Septin PF00735.13 KII67202.1 - 1.3e-91 306.5 0.0 2.1e-91 305.8 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 KII67202.1 - 8.1e-07 29.0 0.0 4.9e-06 26.4 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KII67202.1 - 0.00053 19.8 1.8 0.17 11.6 0.0 3.3 2 1 0 3 3 3 1 Dynamin family AAA_10 PF12846.2 KII67202.1 - 0.0022 17.4 0.1 0.0083 15.5 0.0 1.9 2 0 0 2 2 2 1 AAA-like domain FtsK_SpoIIIE PF01580.13 KII67202.1 - 0.006 16.0 0.0 0.016 14.7 0.0 1.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_32 PF13654.1 KII67202.1 - 0.0063 15.2 2.2 0.31 9.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 KII67202.1 - 0.008 16.6 0.1 0.026 14.9 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein AAA_22 PF13401.1 KII67202.1 - 0.0094 16.0 0.0 0.067 13.3 0.0 2.3 3 0 0 3 3 3 1 AAA domain GTP_EFTU PF00009.22 KII67202.1 - 0.018 14.4 0.1 0.14 11.5 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF258 PF03193.11 KII67202.1 - 0.037 13.2 0.0 0.15 11.2 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_33 PF13671.1 KII67202.1 - 0.088 12.6 0.0 0.33 10.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain FeoB_N PF02421.13 KII67202.1 - 0.1 11.8 0.7 0.7 9.1 0.1 2.5 2 1 0 2 2 2 0 Ferrous iron transport protein B ING PF12998.2 KII67205.1 - 0.0014 18.8 1.1 0.0027 17.9 0.8 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Pkinase PF00069.20 KII67206.1 - 2.5e-59 200.5 0.0 7e-59 199.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII67206.1 - 2.1e-30 105.6 0.2 2.4e-22 79.2 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KII67206.1 - 0.0018 17.2 0.1 0.016 14.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KII67206.1 - 0.0019 17.9 0.1 0.37 10.5 0.1 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 KII67206.1 - 0.0068 15.2 0.0 0.019 13.8 0.0 1.7 2 0 0 2 2 2 1 Seadornavirus VP7 Kdo PF06293.9 KII67206.1 - 0.041 12.9 0.1 0.097 11.7 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.19 KII67206.1 - 0.078 13.5 0.1 0.17 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain DDE_1 PF03184.14 KII67210.1 - 0.0036 16.4 0.0 0.01 15.0 0.0 1.8 1 1 2 3 3 3 1 DDE superfamily endonuclease KH_1 PF00013.24 KII67211.1 - 6e-07 29.0 0.0 1.6e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KII67211.1 - 1.6e-06 27.6 0.1 4.9e-06 26.0 0.0 1.9 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.1 KII67211.1 - 0.0038 16.9 6.4 0.37 10.5 1.8 2.5 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.18 KII67211.1 - 0.025 14.4 9.0 0.36 10.8 0.5 2.7 2 0 0 2 2 2 0 Zinc knuckle PolC_DP2 PF03833.8 KII67211.1 - 0.19 9.3 0.2 0.28 8.7 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-CCHC_4 PF14392.1 KII67211.1 - 1.2 8.9 8.4 1.1 9.0 0.7 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.1 KII67211.1 - 4.1 7.1 6.7 9.1 6.0 0.6 2.7 2 0 0 2 2 2 0 Zinc knuckle DDE_Tnp_IS1595 PF12762.2 KII67214.1 - 1.7e-08 34.4 1.0 6.3e-05 22.8 0.0 2.4 1 1 1 2 2 2 2 ISXO2-like transposase domain DDE_3 PF13358.1 KII67216.1 - 6.3e-13 48.6 0.0 7.1e-13 48.5 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Spond_N PF06468.8 KII67218.1 - 0.05 13.2 0.0 0.054 13.1 0.0 1.1 1 0 0 1 1 1 0 Spondin_N OAF PF14941.1 KII67218.1 - 0.076 12.1 0.0 0.084 12.0 0.0 1.1 1 0 0 1 1 1 0 Transcriptional regulator, Out at first RabGAP-TBC PF00566.13 KII67220.1 - 3.5e-46 157.3 5.9 3.5e-46 157.3 4.1 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain SNF2_N PF00176.18 KII67222.1 - 3.4e-84 282.1 0.1 8.1e-84 280.9 0.1 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 KII67222.1 - 1.5e-37 127.9 0.9 7.7e-37 125.6 0.6 2.4 1 0 0 1 1 1 1 SLIDE HAND PF09110.6 KII67222.1 - 7.4e-27 93.9 2.0 7.4e-27 93.9 1.4 5.1 5 1 0 5 5 5 1 HAND Helicase_C PF00271.26 KII67222.1 - 1.6e-15 56.6 0.0 4.5e-15 55.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KII67222.1 - 1.6e-08 34.2 0.0 2.7e-07 30.2 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 KII67222.1 - 2.8e-06 27.2 0.0 2.8e-06 27.2 0.0 4.4 5 1 0 5 5 5 1 Type III restriction enzyme, res subunit MutS_III PF05192.13 KII67222.1 - 0.0039 17.0 0.0 0.12 12.0 0.0 2.6 2 2 0 2 2 2 1 MutS domain III Myb_DNA-binding PF00249.26 KII67222.1 - 0.052 13.6 0.0 0.82 9.7 0.0 3.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain DDE_1 PF03184.14 KII67224.1 - 0.00029 20.0 0.0 0.00042 19.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Miro PF08477.8 KII67224.1 - 0.046 14.2 0.1 0.069 13.6 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein DDE_3 PF13358.1 KII67225.1 - 4.6e-30 104.2 0.0 9.2e-30 103.3 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.1 KII67225.1 - 3.6e-10 40.4 0.0 8.5e-09 36.0 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII67225.1 - 6.7e-08 32.6 0.0 1.2e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII67225.1 - 1.8e-07 30.5 2.1 9.3e-07 28.3 0.0 2.6 3 0 0 3 3 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII67225.1 - 6.8e-06 25.9 0.2 4.9e-05 23.2 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII67225.1 - 0.0031 17.1 0.1 0.0053 16.4 0.1 1.3 1 0 0 1 1 1 1 Transposase Toxin_64 PF15542.1 KII67225.1 - 0.0042 17.6 6.5 1.7 9.2 3.0 3.1 2 1 0 2 2 2 1 Putative toxin 64 PAX PF00292.13 KII67225.1 - 0.0044 16.7 0.2 0.0097 15.6 0.1 1.5 1 0 0 1 1 1 1 'Paired box' domain TrmB PF01978.14 KII67225.1 - 0.0061 16.2 0.1 0.013 15.1 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_40 PF14493.1 KII67225.1 - 0.0093 16.1 0.6 0.046 13.9 0.1 2.4 2 1 1 3 3 3 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII67225.1 - 0.012 15.6 0.2 0.12 12.4 0.0 2.5 2 0 0 2 2 2 0 Transposase HTH_33 PF13592.1 KII67225.1 - 0.013 15.0 0.0 0.036 13.6 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn helix DDE_1 PF03184.14 KII67225.1 - 0.015 14.4 0.4 0.29 10.2 0.0 2.5 2 1 1 3 3 3 0 DDE superfamily endonuclease Rep_3 PF01051.16 KII67225.1 - 0.034 13.7 0.1 0.063 12.8 0.1 1.5 1 0 0 1 1 1 0 Initiator Replication protein Dynamin_N PF00350.18 KII67226.1 - 1.1e-50 171.7 1.1 3.4e-50 170.1 0.1 2.2 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.15 KII67226.1 - 1.4e-49 168.5 12.8 1.5e-34 119.0 4.0 3.2 2 1 1 3 3 3 2 Dynamin central region MMR_HSR1 PF01926.18 KII67226.1 - 0.00043 20.2 0.0 0.0013 18.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase PAH PF02671.16 KII67226.1 - 0.008 15.7 0.1 1.2 8.8 0.0 3.2 2 1 0 2 2 2 1 Paired amphipathic helix repeat PH PF00169.24 KII67226.1 - 0.011 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 PH domain Miro PF08477.8 KII67226.1 - 0.012 16.0 0.0 0.04 14.4 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein DUF2573 PF10835.3 KII67226.1 - 0.071 13.1 0.2 0.46 10.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2573) GED PF02212.13 KII67227.1 - 0.037 13.9 0.6 0.074 12.9 0.4 1.5 1 0 0 1 1 1 0 Dynamin GTPase effector domain NRDE-2 PF08424.5 KII67228.1 - 3.1e-51 174.1 0.1 5.9e-51 173.2 0.1 1.4 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference FLYWCH PF04500.11 KII67229.1 - 9.2e-09 35.0 0.2 1.8e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 KII67229.1 - 3.2e-06 27.1 0.0 8.5e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain DDE_3 PF13358.1 KII67230.1 - 2.3e-06 27.4 0.0 3.3e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease SURF1 PF02104.10 KII67231.1 - 5.3e-17 62.3 0.0 1.1e-16 61.3 0.0 1.5 1 1 0 1 1 1 1 SURF1 family HTH_24 PF13412.1 KII67232.1 - 0.064 12.6 0.8 4.7 6.6 0.0 2.4 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding NuA4 PF09340.5 KII67233.1 - 0.0026 17.3 0.3 0.0051 16.4 0.2 1.5 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 FlgN PF05130.7 KII67233.1 - 0.0074 16.5 2.3 0.0093 16.2 1.6 1.1 1 0 0 1 1 1 1 FlgN protein RNA_pol_Rpb2_3 PF04565.11 KII67233.1 - 0.22 11.2 1.0 0.4 10.4 0.5 1.7 1 1 0 1 1 1 0 RNA polymerase Rpb2, domain 3 SMC_hinge PF06470.8 KII67235.1 - 1.2e-26 92.9 0.0 3.1e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.14 KII67235.1 - 2.1e-24 85.9 11.2 3.9e-24 85.0 7.8 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 KII67235.1 - 0.014 15.2 0.0 0.045 13.6 0.0 1.9 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit COG2 PF06148.6 KII67235.1 - 0.15 11.9 13.4 2.6 7.8 2.0 4.2 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4611 PF15387.1 KII67235.1 - 0.19 11.8 5.0 3.2 7.9 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) SMC_N PF02463.14 KII67236.1 - 1.3e-05 24.5 12.1 6.8e-05 22.2 8.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Jnk-SapK_ap_N PF09744.4 KII67236.1 - 0.66 9.9 24.6 2.1 8.3 10.3 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 IncA PF04156.9 KII67236.1 - 7.1 6.1 30.4 5 6.6 4.9 2.2 1 1 1 2 2 2 0 IncA protein Atg14 PF10186.4 KII67236.1 - 7.5 5.4 18.9 11 4.8 13.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DDE_3 PF13358.1 KII67237.1 - 1.1e-16 60.9 0.0 1.4e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease PT PF04886.7 KII67240.1 - 0.27 10.5 3.6 0.52 9.6 2.5 1.5 1 1 0 1 1 1 0 PT repeat DDE_Tnp_IS1595 PF12762.2 KII67241.1 - 1.2e-05 25.1 0.2 2.3e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain Ran_BP1 PF00638.13 KII67242.1 - 2.9e-41 140.3 1.7 4.6e-41 139.7 1.2 1.3 1 0 0 1 1 1 1 RanBP1 domain UPF0240 PF06784.6 KII67242.1 - 0.0028 17.3 3.2 0.005 16.5 2.2 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0240) WH1 PF00568.18 KII67242.1 - 0.003 17.2 0.2 0.0055 16.4 0.2 1.4 1 1 0 1 1 1 1 WH1 domain RRM_1 PF00076.17 KII67243.1 - 7.4e-05 22.3 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_pol_viral_N PF00242.12 KII67243.1 - 3.4 6.5 13.1 4.4 6.2 9.1 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF2270 PF10028.4 KII67250.1 - 0.011 15.1 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) Kelch_6 PF13964.1 KII67251.1 - 1e-28 98.2 14.2 1.7e-06 27.9 0.1 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII67251.1 - 2.1e-24 84.7 12.8 1.1e-06 28.1 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 KII67251.1 - 2.9e-22 78.1 15.7 1e-05 25.1 0.1 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII67251.1 - 5.9e-22 77.2 7.0 0.00033 20.7 0.0 7.0 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII67251.1 - 1.4e-13 50.4 13.1 0.0015 18.3 0.0 6.4 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 KII67251.1 - 5.7e-12 44.9 11.5 0.029 14.1 0.0 5.7 6 0 0 6 6 6 3 Kelch motif Rax2 PF12768.2 KII67251.1 - 0.00031 20.0 1.5 0.24 10.5 0.1 2.7 1 1 2 3 3 3 2 Cortical protein marker for cell polarity FAM176 PF14851.1 KII67253.1 - 0.0031 17.1 1.8 0.0031 17.1 1.2 2.5 2 1 1 3 3 3 1 FAM176 family NPR3 PF03666.8 KII67253.1 - 1 7.7 6.3 0.29 9.6 2.3 1.5 1 1 1 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 RVT_1 PF00078.22 KII67254.1 - 3.8e-05 23.1 0.1 0.058 12.7 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) YcgL PF05166.8 KII67254.1 - 0.076 13.1 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 YcgL domain Ldl_recept_a PF00057.13 KII67255.1 - 4.2e-07 29.7 9.5 4.2e-07 29.7 6.6 3.2 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A SNAP PF14938.1 KII67256.1 - 0.0013 17.9 0.2 0.0021 17.2 0.2 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP AA_synth PF06684.6 KII67256.1 - 0.075 12.3 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Amino acid synthesis Macoilin PF09726.4 KII67257.1 - 0.062 11.5 1.2 0.076 11.2 0.8 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF3837 PF12939.2 KII67257.1 - 0.062 13.3 1.4 0.43 10.6 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3837) rve PF00665.21 KII67258.1 - 0.00058 19.9 0.0 0.0018 18.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Spermine_synth PF01564.12 KII67259.1 - 1.8e-63 213.7 0.0 2.2e-63 213.4 0.0 1.0 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 KII67259.1 - 1.5e-05 24.6 0.7 9.3e-05 22.0 0.1 2.0 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KII67259.1 - 0.0055 17.0 0.0 0.0095 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain HTH_38 PF13936.1 KII67260.1 - 3.6e-07 29.6 0.0 5.8e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII67260.1 - 4.7e-07 29.9 0.0 5.5e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII67260.1 - 1.3e-06 27.8 0.0 2.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII67260.1 - 3e-06 27.1 0.1 5.7e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.13 KII67260.1 - 0.00019 21.1 0.1 0.00022 20.9 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.1 KII67260.1 - 0.0011 18.7 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII67260.1 - 0.0011 18.5 0.1 0.0013 18.3 0.1 1.1 1 0 0 1 1 1 1 Transposase HTH_11 PF08279.7 KII67260.1 - 0.0044 16.6 0.3 0.0075 15.9 0.2 1.4 1 0 0 1 1 1 1 HTH domain HTH_40 PF14493.1 KII67260.1 - 0.011 15.8 0.1 0.018 15.2 0.1 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.10 KII67260.1 - 0.014 15.1 1.3 0.062 13.1 0.0 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase Sigma70_r4 PF04545.11 KII67260.1 - 0.029 13.6 0.0 0.17 11.2 0.0 2.1 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_Tnp_1 PF01527.15 KII67260.1 - 0.031 14.2 0.0 0.04 13.8 0.0 1.4 1 1 0 1 1 1 0 Transposase Helicase_RecD PF05127.9 KII67260.1 - 0.042 13.4 0.0 0.047 13.3 0.0 1.1 1 0 0 1 1 1 0 Helicase MarR PF01047.17 KII67260.1 - 0.053 13.2 0.2 0.3 10.8 0.1 2.1 1 1 0 1 1 1 0 MarR family TrmB PF01978.14 KII67260.1 - 0.053 13.2 0.1 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_32 PF13565.1 KII67260.1 - 0.11 13.3 0.0 0.21 12.4 0.0 1.4 2 0 0 2 2 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.7 KII67260.1 - 0.12 11.7 0.1 0.5 9.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 DDE_3 PF13358.1 KII67261.1 - 6.1e-17 61.7 0.0 1.2e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease PAX PF00292.13 KII67261.1 - 1.3e-07 31.4 0.0 2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_24 PF13412.1 KII67261.1 - 3.1e-07 29.6 0.3 0.00016 20.9 0.0 2.3 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_23 PF13384.1 KII67261.1 - 1e-06 28.1 0.0 8.9e-06 25.1 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain MarR_2 PF12802.2 KII67261.1 - 2.2e-06 27.2 0.0 4.4e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_29 PF13551.1 KII67261.1 - 6.2e-06 26.3 0.0 9.3e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix TrmB PF01978.14 KII67261.1 - 8.1e-05 22.2 0.0 0.00033 20.3 0.0 2.0 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB CENP-B_N PF04218.8 KII67261.1 - 0.00013 21.3 0.0 0.00028 20.2 0.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.1 KII67261.1 - 0.00031 20.6 0.0 0.00085 19.2 0.0 1.8 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_38 PF13936.1 KII67261.1 - 0.00062 19.2 0.2 0.0043 16.5 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4 PF04545.11 KII67261.1 - 0.00065 18.9 0.0 0.0016 17.6 0.0 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 Fe_dep_repress PF01325.14 KII67261.1 - 0.00072 19.4 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_IclR PF09339.5 KII67261.1 - 0.00081 18.9 0.0 0.0044 16.5 0.0 2.1 2 0 0 2 2 2 1 IclR helix-turn-helix domain Phage_CI_repr PF07022.8 KII67261.1 - 0.0042 17.1 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain HTH_32 PF13565.1 KII67261.1 - 0.0054 17.4 0.4 0.011 16.5 0.0 1.7 2 0 0 2 2 1 1 Homeodomain-like domain LacI PF00356.16 KII67261.1 - 0.014 15.0 0.2 0.04 13.5 0.1 1.9 2 1 0 2 2 2 0 Bacterial regulatory proteins, lacI family HTH_27 PF13463.1 KII67261.1 - 0.021 15.1 0.1 0.14 12.5 0.0 2.2 2 1 1 3 3 2 0 Winged helix DNA-binding domain HTH_Tnp_ISL3 PF13542.1 KII67261.1 - 0.035 13.2 0.0 0.14 11.3 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Sigma70_r4_2 PF08281.7 KII67261.1 - 0.036 13.5 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_Tnp_Tc3_2 PF01498.13 KII67261.1 - 0.036 14.1 0.3 5.1 7.2 0.0 2.3 2 0 0 2 2 2 0 Transposase HTH_3 PF01381.17 KII67261.1 - 0.077 12.8 0.1 0.18 11.6 0.0 1.7 2 0 0 2 2 1 0 Helix-turn-helix MarR PF01047.17 KII67261.1 - 0.11 12.2 0.2 0.35 10.6 0.0 1.9 2 0 0 2 2 1 0 MarR family CRIC_ras_sig PF10534.4 KII67261.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras GrpE PF01025.14 KII67262.1 - 5.9e-34 117.0 0.3 7.2e-34 116.7 0.2 1.1 1 0 0 1 1 1 1 GrpE TMF_DNA_bd PF12329.3 KII67262.1 - 0.0041 16.8 3.2 0.0064 16.2 2.2 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding DUF3972 PF13118.1 KII67262.1 - 0.0068 16.4 1.2 0.012 15.6 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3972) DivIC PF04977.10 KII67262.1 - 0.065 12.7 1.0 0.17 11.4 0.7 1.7 1 0 0 1 1 1 0 Septum formation initiator ASD2 PF08687.6 KII67262.1 - 0.083 12.2 2.6 0.11 11.8 1.8 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 SlyX PF04102.7 KII67262.1 - 0.12 12.7 1.2 0.27 11.6 0.5 1.9 1 1 0 1 1 1 0 SlyX FEZ PF07763.8 KII67262.1 - 0.13 11.9 4.0 0.21 11.2 2.8 1.2 1 0 0 1 1 1 0 FEZ-like protein DUF1202 PF06717.6 KII67262.1 - 0.15 11.3 4.2 0.088 12.0 1.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1202) DUF1154 PF06631.6 KII67262.1 - 0.96 9.1 3.5 4.9 6.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) EXS PF03124.9 KII67263.1 - 7.7e-24 84.3 12.5 7.7e-24 84.3 8.6 1.7 2 0 0 2 2 2 1 EXS family SPX PF03105.14 KII67263.1 - 5.1e-20 72.3 5.5 8.8e-14 51.9 2.9 2.1 2 0 0 2 2 2 2 SPX domain MGC-24 PF05283.6 KII67266.1 - 9.2 6.0 9.7 25 4.6 6.7 1.7 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Nucleoside_tran PF01733.13 KII67271.1 - 0.00045 19.4 10.1 0.044 12.9 0.3 3.4 2 1 0 3 3 3 3 Nucleoside transporter Pkinase_C PF00433.19 KII67271.1 - 0.012 16.0 4.8 0.19 12.3 0.0 4.0 4 0 0 4 4 4 0 Protein kinase C terminal domain EphA2_TM PF14575.1 KII67271.1 - 0.051 13.9 1.9 9.3 6.7 0.0 3.4 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Glucos_trans_II PF14264.1 KII67271.1 - 0.16 10.9 5.2 3.6 6.4 0.1 3.0 3 0 0 3 3 3 0 Glucosyl transferase GtrII Tetraspannin PF00335.15 KII67271.1 - 0.79 8.9 7.5 23 4.1 0.5 3.1 2 1 1 4 4 4 0 Tetraspanin family FeoB_C PF07664.7 KII67271.1 - 2.7 7.5 11.4 1.2 8.6 0.4 3.1 3 0 0 3 3 3 0 Ferrous iron transport protein B C terminus BatD PF13584.1 KII67272.1 - 0.031 12.8 0.4 0.036 12.6 0.3 1.1 1 0 0 1 1 1 0 Oxygen tolerance ABC2_membrane_3 PF12698.2 KII67274.1 - 0.27 10.2 2.6 0.32 9.9 1.8 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1958 PF09211.5 KII67274.1 - 0.42 10.7 2.9 0.48 10.5 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1958) POLO_box PF00659.13 KII67274.1 - 0.56 10.2 3.6 2.2 8.3 0.1 2.8 2 1 0 2 2 2 0 POLO box duplicated region DUF768 PF05589.6 KII67275.1 - 0.00011 21.9 7.5 5.9 6.8 0.2 4.6 1 1 1 4 4 4 4 Protein of unknown function (DUF768) Sbi-IV PF11621.3 KII67277.1 - 0.11 12.6 0.3 0.11 12.6 0.2 1.6 2 0 0 2 2 2 0 C3 binding domain 4 of IgG-bind protein SBI zf-3CxxC PF13695.1 KII67278.1 - 0.2 11.8 2.9 0.28 11.4 0.1 2.3 3 0 0 3 3 3 0 Zinc-binding domain PIRT PF15099.1 KII67279.1 - 0.064 12.4 0.1 0.12 11.6 0.1 1.4 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family DUF4381 PF14316.1 KII67279.1 - 0.091 12.8 0.1 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Hemagglutinin PF00509.13 KII67279.1 - 0.1 10.7 0.1 0.25 9.4 0.0 1.6 2 0 0 2 2 2 0 Haemagglutinin DUF3487 PF11990.3 KII67279.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Lamp PF01299.12 KII67279.1 - 1.9 7.5 5.6 0.66 9.0 1.6 1.8 1 1 1 2 2 2 0 Lysosome-associated membrane glycoprotein (Lamp) DUF2062 PF09835.4 KII67280.1 - 0.058 12.9 0.0 0.087 12.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) TRP PF06011.7 KII67280.1 - 0.1 11.1 0.4 0.15 10.5 0.3 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel KH_dom-like PF14714.1 KII67281.1 - 0.14 12.1 0.1 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal CBM27 PF09212.5 KII67282.1 - 0.085 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate binding module 27 Stc1 PF12898.2 KII67283.1 - 0.0086 16.1 1.0 0.032 14.2 0.1 2.2 2 0 0 2 2 2 1 Stc1 domain DUF2516 PF10724.4 KII67284.1 - 0.0084 16.0 0.1 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2516) MARVEL PF01284.18 KII67288.1 - 0.059 13.1 0.1 0.071 12.9 0.0 1.2 1 0 0 1 1 1 0 Membrane-associating domain DUF1180 PF06679.7 KII67288.1 - 0.077 12.8 0.1 0.098 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RNase_PH PF01138.16 KII67289.1 - 2.9e-13 50.2 0.0 3.5e-13 50.0 0.0 1.0 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF2577 PF10844.3 KII67290.1 - 0.04 13.9 0.7 0.062 13.3 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2577) TMEM154 PF15102.1 KII67291.1 - 0.00027 20.6 13.4 0.00057 19.6 9.3 1.6 1 1 0 1 1 1 1 TMEM154 protein family EVI2A PF05399.6 KII67291.1 - 0.00038 19.7 4.3 0.00043 19.5 3.0 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) CD34_antigen PF06365.7 KII67291.1 - 0.00086 19.0 4.9 0.0015 18.2 3.4 1.3 1 1 0 1 1 1 1 CD34/Podocalyxin family Rifin_STEVOR PF02009.11 KII67291.1 - 0.0015 18.2 0.7 0.0017 18.0 0.5 1.0 1 0 0 1 1 1 1 Rifin/stevor family Podoplanin PF05808.6 KII67291.1 - 0.0019 17.7 7.0 0.0025 17.3 4.9 1.1 1 0 0 1 1 1 1 Podoplanin AJAP1_PANP_C PF15298.1 KII67291.1 - 0.012 15.5 5.6 0.014 15.3 3.9 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Tetraspannin PF00335.15 KII67291.1 - 0.029 13.6 1.4 0.034 13.4 0.7 1.3 1 1 0 1 1 1 0 Tetraspanin family Plasmodium_Vir PF05795.6 KII67291.1 - 0.041 13.0 2.9 0.045 12.9 2.0 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TrbL PF04610.9 KII67291.1 - 0.041 13.5 0.0 0.049 13.3 0.0 1.1 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein DUF4448 PF14610.1 KII67291.1 - 0.047 13.1 0.1 0.07 12.6 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Ycf1 PF05758.7 KII67291.1 - 0.056 11.1 1.5 0.053 11.2 1.0 1.1 1 0 0 1 1 1 0 Ycf1 Tim54 PF11711.3 KII67291.1 - 0.06 11.9 2.0 0.066 11.7 1.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pox_P21 PF05313.7 KII67291.1 - 0.079 12.2 0.8 0.14 11.4 0.5 1.3 1 0 0 1 1 1 0 Poxvirus P21 membrane protein TRP PF06011.7 KII67291.1 - 0.11 10.9 0.3 0.13 10.7 0.2 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel ETRAMP PF09716.5 KII67291.1 - 0.21 11.5 1.3 0.43 10.5 0.9 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3753 PF12575.3 KII67291.1 - 0.28 11.0 2.7 0.25 11.1 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3753) Nucleoside_tran PF01733.13 KII67291.1 - 0.5 9.4 2.9 0.59 9.2 2.0 1.2 1 0 0 1 1 1 0 Nucleoside transporter DUF3357 PF11837.3 KII67291.1 - 0.73 9.7 3.5 0.55 10.1 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF912 PF06024.7 KII67291.1 - 1.9 8.5 7.5 10 6.2 5.2 1.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1632 PF07857.7 KII67291.1 - 3.6 6.7 6.9 0.65 9.2 1.1 2.0 1 1 1 2 2 2 0 CEO family (DUF1632) DUF3377 PF11857.3 KII67293.1 - 0.0026 17.3 0.0 0.0026 17.3 0.0 2.3 2 1 1 3 3 3 1 Domain of unknown function (DUF3377) Rifin_STEVOR PF02009.11 KII67293.1 - 0.023 14.3 8.9 0.041 13.5 4.3 2.0 1 1 1 2 2 2 0 Rifin/stevor family PLRV_ORF5 PF01690.12 KII67293.1 - 0.27 10.3 19.6 0.38 9.8 13.6 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein TRP PF06011.7 KII67293.1 - 0.82 8.1 4.9 1.4 7.4 3.4 1.5 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel EphA2_TM PF14575.1 KII67293.1 - 1.1 9.6 4.2 2.7 8.4 0.8 2.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain FAM196 PF15265.1 KII67293.1 - 1.4 8.0 24.8 1.8 7.7 17.2 1.1 1 0 0 1 1 1 0 FAM196 family Macoilin PF09726.4 KII67293.1 - 2.1 6.5 21.9 2.5 6.2 15.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Utp14 PF04615.8 KII67293.1 - 2.6 6.0 27.4 3.4 5.7 19.0 1.1 1 0 0 1 1 1 0 Utp14 protein DUF966 PF06136.8 KII67293.1 - 7.1 5.9 24.4 9.9 5.4 16.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TetR_C_2 PF08361.6 KII67299.1 - 0.0062 16.4 0.3 0.011 15.6 0.2 1.3 1 0 0 1 1 1 1 MAATS-type transcriptional repressor, C-terminal region DDE_Tnp_IS1595 PF12762.2 KII67302.1 - 5.6e-17 61.9 0.5 9e-17 61.3 0.3 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII67302.1 - 3.1e-05 23.3 0.2 3.4e-05 23.1 0.1 1.0 1 0 0 1 1 1 1 Transposase IS66 family DDE_Tnp_IS240 PF13610.1 KII67302.1 - 0.046 13.6 0.3 0.066 13.1 0.2 1.3 1 0 0 1 1 1 0 DDE domain FAM60A PF15396.1 KII67303.1 - 1.3e-05 25.0 0.5 2.4e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 Protein Family FAM60A CPG4 PF15481.1 KII67304.1 - 0.076 13.3 0.3 0.18 12.1 0.2 1.8 1 0 0 1 1 1 0 Chondroitin proteoglycan 4 TRM PF02005.11 KII67305.1 - 0.02 13.8 0.1 0.027 13.3 0.1 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase CRAL_TRIO_2 PF13716.1 KII67305.1 - 0.039 13.8 0.3 0.061 13.2 0.2 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain DDE_Tnp_IS1595 PF12762.2 KII67307.1 - 2.9e-08 33.6 0.0 4.1e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII67308.1 - 2.9e-08 33.6 0.0 4.1e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII67309.1 - 0.0011 18.7 0.0 0.0019 18.0 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain Lectin_leg-like PF03388.8 KII67312.1 - 9.1e-05 21.6 0.3 9.7e-05 21.5 0.2 1.1 1 0 0 1 1 1 1 Legume-like lectin family DUF596 PF04591.7 KII67312.1 - 0.12 12.3 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF596 RVP PF00077.15 KII67315.1 - 0.00047 20.0 0.0 0.00083 19.2 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII67315.1 - 0.013 15.9 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII67315.1 - 0.033 13.9 0.0 0.061 13.1 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RED_C PF07807.6 KII67316.1 - 0.039 14.1 0.0 0.064 13.4 0.0 1.3 1 0 0 1 1 1 0 RED-like protein C-terminal region IF-2B PF01008.12 KII67318.1 - 7.8e-61 205.5 0.2 9.1e-61 205.3 0.1 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF2254 PF10011.4 KII67325.1 - 0.12 10.8 0.1 0.16 10.3 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) DUF766 PF05571.7 KII67325.1 - 0.34 10.1 5.3 0.051 12.8 1.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF766) Ank_2 PF12796.2 KII67326.1 - 1.5e-98 323.3 34.9 4.2e-19 68.6 0.6 9.0 3 1 7 10 10 10 9 Ankyrin repeats (3 copies) Ank PF00023.25 KII67326.1 - 2e-81 263.9 37.7 2e-08 33.6 0.0 16.1 16 0 0 16 16 16 15 Ankyrin repeat Ank_4 PF13637.1 KII67326.1 - 4.2e-74 243.7 29.6 9.1e-11 41.9 0.0 11.6 6 3 6 12 12 12 12 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII67326.1 - 4.2e-65 209.1 39.8 1.7e-05 24.6 0.3 18.2 18 0 0 18 18 18 15 Ankyrin repeat Ank_5 PF13857.1 KII67326.1 - 4.3e-65 214.2 30.8 1.8e-08 34.3 0.0 13.2 5 4 7 13 13 13 12 Ankyrin repeats (many copies) EpoR_lig-bind PF09067.5 KII67331.1 - 0.087 12.8 0.1 0.19 11.7 0.0 1.6 1 1 1 2 2 2 0 Erythropoietin receptor, ligand binding DUF3050 PF11251.3 KII67332.1 - 0.062 12.5 0.2 0.073 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3050) THOC7 PF05615.8 KII67332.1 - 0.076 13.2 1.2 0.087 13.0 0.8 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 Molybdopterin PF00384.17 KII67334.1 - 6.5e-49 166.8 0.0 1.1e-46 159.5 0.0 2.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH-G_4Fe-4S_3 PF10588.4 KII67334.1 - 1.1e-17 62.9 0.3 2.7e-17 61.7 0.2 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.1 KII67334.1 - 7.8e-17 60.8 0.0 1.8e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF1982 PF09326.6 KII67334.1 - 2.4e-10 40.4 0.0 7.3e-10 38.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1982) Fer2 PF00111.22 KII67334.1 - 4.6e-09 35.8 1.6 5.9e-09 35.5 0.1 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Med13_N PF11597.3 KII67334.1 - 0.016 13.9 0.0 0.02 13.5 0.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal Fer4 PF00037.22 KII67334.1 - 0.096 12.3 2.4 11 5.8 0.0 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Cys_rich_CWC PF14375.1 KII67334.1 - 1.3 9.0 6.2 1.2 9.0 1.7 2.4 2 0 0 2 2 2 0 Cysteine-rich CWC Sod_Fe_C PF02777.13 KII67335.1 - 1.8e-29 101.7 1.1 1.9e-29 101.6 0.1 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 KII67335.1 - 4.9e-24 84.4 4.8 6.1e-24 84.0 2.0 2.0 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain PurA PF04845.8 KII67336.1 - 0.0032 16.6 1.0 0.09 11.8 0.0 2.4 2 1 0 2 2 2 2 PurA ssDNA and RNA-binding protein DDE_3 PF13358.1 KII67338.1 - 2.4e-13 50.0 0.0 4.3e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII67338.1 - 0.0011 19.1 0.1 0.0026 17.8 0.1 1.7 2 0 0 2 2 2 1 Winged helix-turn helix TrmB PF01978.14 KII67338.1 - 0.0052 16.4 0.1 0.058 13.1 0.0 2.2 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB PAX PF00292.13 KII67338.1 - 0.011 15.3 0.2 0.02 14.6 0.1 1.4 1 0 0 1 1 1 0 'Paired box' domain HTH_28 PF13518.1 KII67338.1 - 0.02 14.9 0.9 0.027 14.4 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_37 PF13744.1 KII67338.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3634 PF12321.3 KII67338.1 - 0.11 12.4 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3634) RNA_pol_Rpb6 PF01192.17 KII67339.1 - 0.15 11.7 0.3 14 5.4 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb6 PTPS PF01242.14 KII67341.1 - 0.025 14.2 0.5 0.17 11.5 0.1 2.0 1 1 1 2 2 2 0 6-pyruvoyl tetrahydropterin synthase WD40 PF00400.27 KII67342.1 - 3.7e-06 26.5 4.7 0.038 13.8 0.1 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat DUF912 PF06024.7 KII67348.1 - 0.036 14.0 0.5 0.036 14.0 0.3 2.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SAP30_Sin3_bdg PF13867.1 KII67349.1 - 0.1 12.4 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Cofilin_ADF PF00241.15 KII67350.1 - 4.3e-05 23.4 0.7 0.00054 19.8 0.1 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein RRM_1 PF00076.17 KII67352.1 - 2e-28 97.8 0.9 1.4e-13 50.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII67352.1 - 2.1e-23 82.0 0.4 3.2e-13 49.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII67352.1 - 1.1e-07 31.5 0.6 0.0027 17.5 0.1 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 KII67352.1 - 0.0045 16.4 0.0 3.5 7.2 0.0 2.4 2 0 0 2 2 2 2 Ribonuclease B OB domain NID PF07292.8 KII67352.1 - 0.14 12.1 0.0 6.2 6.9 0.0 2.9 2 1 0 2 2 2 0 Nmi/IFP 35 domain (NID) RVT_1 PF00078.22 KII67355.1 - 2e-14 53.4 0.0 3.1e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII67355.1 - 8.5e-07 28.8 0.4 2e-06 27.6 0.1 1.8 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII67355.1 - 0.0004 20.8 0.1 0.00072 20.0 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII67355.1 - 0.0018 18.0 0.0 0.0046 16.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease cwf21 PF08312.7 KII67357.1 - 0.0066 16.2 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 cwf21 domain DUF4041 PF13250.1 KII67357.1 - 0.19 11.3 1.2 3.8 7.1 0.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4041) FlaC_arch PF05377.6 KII67357.1 - 0.49 10.3 2.7 1.2 9.0 0.3 2.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Baculo_ME53 PF06061.6 KII67359.1 - 0.053 12.5 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Baculoviridae ME53 PuR_N PF09182.5 KII67359.1 - 0.06 12.9 0.3 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 Bacterial purine repressor, N-terminal rve PF00665.21 KII67360.1 - 4.6e-17 62.2 0.0 9.4e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII67360.1 - 0.0038 16.7 0.1 0.0079 15.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain ASC PF00858.19 KII67360.1 - 0.011 14.4 0.2 0.013 14.1 0.2 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel RIX1 PF08167.7 KII67361.1 - 0.017 14.7 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis Tannase PF07519.6 KII67361.1 - 0.053 12.2 0.0 0.06 12.0 0.0 1.1 1 0 0 1 1 1 0 Tannase and feruloyl esterase Peptidase_A17 PF05380.8 KII67361.1 - 0.088 12.6 0.0 0.12 12.1 0.0 1.4 1 1 0 1 1 1 0 Pao retrotransposon peptidase Thymidylat_synt PF00303.14 KII67361.1 - 0.1 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Thymidylate synthase RVT_1 PF00078.22 KII67362.1 - 8.5e-11 41.6 1.9 3e-07 30.0 0.1 2.6 3 0 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) RIX1 PF08167.7 KII67362.1 - 0.043 13.4 0.0 0.085 12.5 0.0 1.4 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis PDGF_N PF04692.8 KII67362.1 - 0.3 11.6 1.1 0.87 10.1 0.1 2.1 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region DUF3053 PF11254.3 KII67363.1 - 0.037 13.2 0.8 3 7.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) MscL PF01741.13 KII67364.1 - 0.075 13.1 0.7 1.1 9.4 0.0 2.3 2 1 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL DUF2435 PF10363.4 KII67364.1 - 0.078 12.8 1.2 4.3 7.3 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2435) UPF0047 PF01894.12 KII67365.1 - 0.082 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0047 Antimicrobial19 PF08225.6 KII67368.1 - 0.066 12.6 0.1 0.15 11.5 0.1 1.6 1 0 0 1 1 1 0 Pseudin antimicrobial peptide Herpes_UL25 PF01499.11 KII67369.1 - 0.045 12.0 3.6 0.047 12.0 2.5 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family DUF1690 PF07956.6 KII67369.1 - 0.51 10.3 4.2 0.67 9.9 1.9 1.7 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) zf-met2 PF12907.2 KII67370.1 - 0.016 15.1 0.1 0.029 14.3 0.1 1.3 1 0 0 1 1 1 0 Zinc-binding Tcp11 PF05794.8 KII67372.1 - 3.6e-14 52.3 1.8 4e-14 52.1 1.3 1.1 1 0 0 1 1 1 1 T-complex protein 11 Rep_fac_C PF08542.6 KII67373.1 - 7.2e-19 67.5 0.2 1.4e-18 66.6 0.0 1.6 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 KII67373.1 - 1.9e-05 24.4 1.7 2.3e-05 24.1 0.1 1.9 2 1 0 2 2 2 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.8 KII67373.1 - 2.5e-05 23.8 0.3 4.5e-05 23.0 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Dynein_heavy PF03028.10 KII67376.1 - 6.7e-146 487.2 3.7 6.7e-146 487.2 2.6 2.6 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 KII67376.1 - 4.5e-100 335.0 16.3 4.5e-100 335.0 11.3 5.5 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KII67376.1 - 1.1e-76 257.4 0.2 3.2e-75 252.6 0.0 2.5 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 MT PF12777.2 KII67376.1 - 1.5e-38 132.4 9.5 3.8e-38 131.1 6.6 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 KII67376.1 - 7.9e-34 116.4 0.3 2.6e-33 114.7 0.2 1.9 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_5 PF07728.9 KII67376.1 - 2e-31 108.5 0.0 7.9e-10 38.6 0.0 6.4 6 1 0 6 6 5 4 AAA domain (dynein-related subfamily) AAA_7 PF12775.2 KII67376.1 - 1.8e-22 79.7 0.3 1.8e-22 79.7 0.2 4.3 6 0 0 6 6 6 1 P-loop containing dynein motor region D3 AAA_8 PF12780.2 KII67376.1 - 1.2e-18 67.1 1.5 4.6e-18 65.1 0.7 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA PF00004.24 KII67376.1 - 1.1e-15 57.9 0.6 2.2e-06 27.8 0.0 6.3 6 0 0 6 6 6 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KII67376.1 - 2.7e-11 43.7 2.7 5.7e-06 26.5 0.0 7.0 7 1 0 7 7 6 1 AAA domain AAA_16 PF13191.1 KII67376.1 - 2.2e-06 27.8 0.0 0.51 10.3 0.0 5.1 5 0 0 5 5 4 1 AAA ATPase domain AAA_17 PF13207.1 KII67376.1 - 1.1e-05 26.1 0.6 0.45 11.3 0.0 5.3 5 0 0 5 5 3 1 AAA domain AAA_33 PF13671.1 KII67376.1 - 4.1e-05 23.4 0.0 0.01 15.6 0.0 4.2 4 0 0 4 4 4 1 AAA domain Zeta_toxin PF06414.7 KII67376.1 - 0.00016 20.8 0.0 0.0042 16.1 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin AAA_28 PF13521.1 KII67376.1 - 0.00026 20.9 0.5 0.33 10.8 0.0 3.9 4 0 0 4 4 3 1 AAA domain Mg_chelatase PF01078.16 KII67376.1 - 0.00046 19.4 0.0 0.035 13.2 0.0 3.2 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI cobW PF02492.14 KII67376.1 - 0.00048 19.6 0.6 0.037 13.4 0.0 3.9 4 0 0 4 4 4 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 KII67376.1 - 0.00075 19.8 5.1 0.048 13.9 0.0 5.9 6 0 0 6 6 4 1 AAA domain UPF0079 PF02367.12 KII67376.1 - 0.00097 18.7 0.0 3.2 7.3 0.0 3.6 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 KII67376.1 - 0.002 17.0 0.0 0.44 9.3 0.0 3.2 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_19 PF13245.1 KII67376.1 - 0.0022 17.6 0.0 0.34 10.7 0.0 2.9 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 KII67376.1 - 0.0027 17.2 0.0 10 5.6 0.0 4.0 4 0 0 4 4 4 0 AAA domain FtsK_SpoIIIE PF01580.13 KII67376.1 - 0.0031 17.0 0.0 1.5 8.2 0.0 2.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family ABC_tran PF00005.22 KII67376.1 - 0.047 14.0 5.8 1 9.6 0.0 5.0 5 0 0 5 5 5 0 ABC transporter RuBisCO_large_N PF02788.11 KII67376.1 - 0.063 12.9 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain P22_CoatProtein PF11651.3 KII67376.1 - 0.16 10.5 0.0 0.29 9.6 0.0 1.3 1 0 0 1 1 1 0 P22 coat protein - gene protein 5 AAA_25 PF13481.1 KII67376.1 - 0.37 10.1 0.1 3.3 7.0 0.0 2.5 3 0 0 3 3 3 0 AAA domain Rax2 PF12768.2 KII67377.1 - 0.0096 15.1 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity DUF912 PF06024.7 KII67377.1 - 0.01 15.8 0.4 0.015 15.3 0.3 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MULE PF10551.4 KII67378.1 - 1.4e-09 38.0 0.0 6.6e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 MULE transposase domain SNAP PF14938.1 KII67381.1 - 1.8e-40 138.8 12.5 2e-40 138.6 8.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII67381.1 - 0.0009 19.1 13.0 0.11 12.4 0.3 3.7 2 1 3 5 5 5 4 Tetratricopeptide repeat Sel1 PF08238.7 KII67381.1 - 0.0073 16.9 2.8 8.7 7.1 0.0 4.3 3 1 1 4 4 4 1 Sel1 repeat TPR_8 PF13181.1 KII67381.1 - 0.53 10.1 0.1 0.53 10.1 0.1 5.7 5 3 1 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII67381.1 - 1 9.4 17.0 7.4 6.7 0.2 5.8 5 2 1 6 6 6 0 Tetratricopeptide repeat DUF357 PF04010.8 KII67381.1 - 1.8 8.3 6.7 3.7 7.3 0.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF357) Apc3 PF12895.2 KII67381.1 - 1.9 8.6 14.5 1.1 9.4 3.7 3.3 1 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Thymidylate_kin PF02223.12 KII67382.1 - 4.4e-20 71.8 0.0 4.9e-20 71.6 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase NADH-u_ox-rdase PF10785.4 KII67385.1 - 0.019 15.1 0.1 0.043 14.0 0.0 1.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit MULE PF10551.4 KII67386.1 - 4.6e-06 26.6 0.0 1.6e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 MULE transposase domain DDE_3 PF13358.1 KII67388.1 - 4.7e-12 45.8 0.0 5.2e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease BLUF PF04940.7 KII67389.1 - 9.1e-21 73.3 0.1 1.7e-20 72.5 0.1 1.4 1 0 0 1 1 1 1 Sensors of blue-light using FAD EAL PF00563.15 KII67389.1 - 3.5e-07 29.9 0.1 1.2e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 EAL domain EAL PF00563.15 KII67390.1 - 1.8e-28 99.6 0.0 1.9e-28 99.5 0.0 1.0 1 0 0 1 1 1 1 EAL domain DUF3330 PF11809.3 KII67390.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) Anti-adapt_IraP PF10796.4 KII67391.1 - 2.2e-24 85.6 7.5 2.6e-24 85.3 5.2 1.1 1 0 0 1 1 1 1 Sigma-S stabilisation anti-adaptor protein DUF2877 PF11392.3 KII67391.1 - 0.098 12.8 0.3 0.13 12.5 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2877) DUF1852 PF08908.6 KII67392.1 - 1.8e-186 618.4 3.7 2e-186 618.2 2.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1852) Meth_synt_2 PF01717.13 KII67393.1 - 3.1e-41 141.4 0.0 1.6e-40 139.0 0.0 1.8 1 1 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 KII67393.1 - 2.1e-08 33.7 0.0 8.7e-08 31.7 0.0 1.9 2 1 0 2 2 2 1 Cobalamin-independent synthase, N-terminal domain CNP1 PF08750.6 KII67393.1 - 0.00072 19.2 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 CNP1-like family URO-D PF01208.12 KII67393.1 - 0.016 14.1 0.0 0.027 13.3 0.0 1.4 1 1 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) Haemagg_act PF05860.8 KII67394.1 - 3.5e-24 84.8 1.0 3.5e-24 84.8 0.7 3.2 4 0 0 4 4 4 1 haemagglutination activity domain Fil_haemagg PF05594.9 KII67394.1 - 0.83 10.0 49.4 0.048 14.0 3.9 8.1 7 1 0 8 8 8 0 Haemagluttinin repeat Utp12 PF04003.7 KII67399.1 - 1.6e-07 31.1 0.2 2.5e-07 30.5 0.2 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family PCI_Csn8 PF10075.4 KII67399.1 - 0.024 14.4 0.2 0.75 9.5 0.1 2.2 1 1 1 2 2 2 0 COP9 signalosome, subunit CSN8 DUF2955 PF11168.3 KII67402.1 - 0.046 13.3 1.2 0.07 12.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2955) DUF521 PF04412.8 KII67404.1 - 0.033 12.7 0.1 0.038 12.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Ldl_recept_a PF00057.13 KII67405.1 - 0.0043 16.9 4.6 0.012 15.5 3.2 1.8 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF3780 PF12635.2 KII67405.1 - 0.15 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3780) RVT_1 PF00078.22 KII67407.1 - 0.0013 18.1 0.1 0.0021 17.4 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII67409.1 - 0.00047 20.2 0.0 0.0015 18.6 0.0 1.7 1 1 1 2 2 2 1 Integrase core domain Afaf PF15339.1 KII67410.1 - 0.14 11.7 4.0 0.2 11.2 2.7 1.3 1 1 0 1 1 1 0 Acrosome formation-associated factor DDE_3 PF13358.1 KII67412.1 - 4.4e-28 97.8 0.0 5.6e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII67412.1 - 0.01 15.9 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Colicin_Pyocin PF01320.13 KII67412.1 - 0.012 15.4 0.1 0.021 14.6 0.1 1.4 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein DUF2024 PF09630.5 KII67412.1 - 0.086 12.5 0.3 0.18 11.5 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) Myb_DNA-bind_6 PF13921.1 KII67413.1 - 0.0021 18.1 1.2 0.11 12.6 0.0 2.9 3 0 0 3 3 3 1 Myb-like DNA-binding domain RHH_1 PF01402.16 KII67413.1 - 0.14 12.1 0.2 0.65 9.9 0.1 2.2 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family Pkinase PF00069.20 KII67414.1 - 0.0005 19.2 0.0 0.00056 19.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain PCNA_C PF02747.10 KII67418.1 - 2.3e-36 124.5 0.2 3.4e-34 117.5 0.0 2.3 2 1 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.13 KII67418.1 - 5.6e-36 122.8 0.6 9.7e-36 122.0 0.4 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad1 PF02144.11 KII67418.1 - 2.6e-05 23.1 1.7 0.00078 18.2 0.1 2.1 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.8 KII67418.1 - 0.0013 17.9 0.0 0.0043 16.2 0.0 1.8 1 1 0 1 1 1 1 Rad9 DNA_pol3_beta_2 PF02767.11 KII67418.1 - 0.011 15.7 0.1 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase III beta subunit, central domain Hus1 PF04005.7 KII67418.1 - 0.1 11.5 0.2 0.16 10.8 0.1 1.6 1 1 0 1 1 1 0 Hus1-like protein Tetraspannin PF00335.15 KII67419.1 - 6.1e-06 25.6 15.8 7.1e-06 25.4 10.9 1.0 1 0 0 1 1 1 1 Tetraspanin family BT1 PF03092.11 KII67419.1 - 0.09 11.4 7.7 0.13 10.9 5.4 1.2 1 0 0 1 1 1 0 BT1 family ABC2_membrane_2 PF12679.2 KII67419.1 - 1.3 7.8 8.7 1.5 7.5 6.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4282 PF14110.1 KII67419.1 - 8.6 6.6 11.2 4.4 7.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) FHA PF00498.21 KII67420.1 - 9.7e-16 57.6 0.0 1.9e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain Ndc1_Nup PF09531.5 KII67420.1 - 0.58 8.5 3.4 0.57 8.5 2.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF936 PF06075.7 KII67420.1 - 3.3 6.5 13.0 3.7 6.3 9.0 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) HLH PF00010.21 KII67422.1 - 3.4e-08 33.0 0.0 9.1e-08 31.6 0.0 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HALZ PF02183.13 KII67422.1 - 0.00024 20.7 0.4 0.00073 19.2 0.3 1.8 1 0 0 1 1 1 1 Homeobox associated leucine zipper DivIC PF04977.10 KII67422.1 - 0.0018 17.7 0.4 0.0018 17.7 0.3 2.4 3 0 0 3 3 3 1 Septum formation initiator DUF2205 PF10224.4 KII67422.1 - 0.0026 17.2 0.0 0.0077 15.7 0.0 1.8 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) DUF904 PF06005.7 KII67422.1 - 0.013 15.7 0.2 0.013 15.7 0.2 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF904) Stirrup PF09061.1 KII67422.1 - 0.016 15.1 0.1 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 Stirrup DUF4201 PF13870.1 KII67422.1 - 0.02 14.3 6.1 0.12 11.8 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) Nnf1 PF03980.9 KII67422.1 - 0.26 11.3 3.9 0.11 12.4 0.3 2.3 3 0 0 3 3 3 0 Nnf1 PBP PF01161.15 KII67423.1 - 1.5e-24 86.4 0.0 1.9e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PBP PF01161.15 KII67424.1 - 3.4e-27 95.0 0.1 4.1e-27 94.8 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DDE_Tnp_IS1595 PF12762.2 KII67425.1 - 0.012 15.4 0.0 0.025 14.4 0.0 1.7 1 1 0 1 1 1 0 ISXO2-like transposase domain Sec23_trunk PF04811.10 KII67426.1 - 1.1e-55 188.6 0.0 1.9e-55 187.8 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 KII67426.1 - 3.5e-29 100.2 0.4 7.4e-29 99.2 0.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 KII67426.1 - 2.2e-26 92.1 1.4 3.5e-26 91.5 0.2 1.9 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 KII67426.1 - 1.8e-14 52.9 8.0 4.3e-14 51.8 5.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 KII67426.1 - 0.00011 21.8 0.0 0.00025 20.6 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat PBP PF01161.15 KII67427.1 - 1.2e-31 109.5 0.1 1.4e-31 109.3 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Gal-3-0_sulfotr PF06990.6 KII67428.1 - 5.9e-34 117.4 1.3 7.9e-34 116.9 0.9 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase TypeIII_RM_meth PF12564.3 KII67428.1 - 0.042 13.8 2.2 0.64 10.0 0.3 3.1 2 1 1 3 3 3 0 Type III restriction/modification enzyme methylation subunit OTCace_N PF02729.16 KII67428.1 - 0.047 13.3 0.0 0.093 12.3 0.0 1.4 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain UQ_con PF00179.21 KII67429.1 - 5e-20 71.3 0.0 2.5e-18 65.8 0.0 2.3 2 1 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KII67429.1 - 0.045 13.4 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Inositol_P PF00459.20 KII67430.1 - 2.4e-35 122.1 0.0 2.9e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family Proteasome PF00227.21 KII67431.1 - 5.6e-31 107.2 0.0 6.4e-31 107.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TcdB_N PF12918.2 KII67432.1 - 0.012 15.6 0.2 0.03 14.3 0.2 1.6 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain Sed5p PF11416.3 KII67432.1 - 0.13 11.7 0.8 0.28 10.6 0.6 1.5 1 0 0 1 1 1 0 Integral membrane protein Sed5p DUF4455 PF14643.1 KII67432.1 - 0.13 10.8 0.0 0.16 10.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) BRCT PF00533.21 KII67433.1 - 7.7e-08 32.3 0.3 5.9e-05 23.1 0.1 2.2 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Ank_2 PF12796.2 KII67434.1 - 6e-28 97.0 0.1 2.3e-15 56.7 0.0 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KII67434.1 - 2.9e-18 65.8 0.1 2.8e-10 40.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KII67434.1 - 1.1e-16 59.7 0.3 2.1e-10 39.8 0.0 3.7 3 1 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KII67434.1 - 1.6e-13 50.3 0.3 2.6e-10 40.1 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII67434.1 - 8.4e-11 41.0 0.0 2.3e-07 30.3 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Shigella_OspC PF06128.6 KII67434.1 - 0.00093 18.7 0.1 0.11 11.9 0.0 2.2 1 1 1 2 2 2 2 Shigella flexneri OspC protein ORC2 PF04084.9 KII67436.1 - 1.1e-38 132.9 11.8 7e-31 107.2 3.7 2.1 1 1 1 2 2 2 2 Origin recognition complex subunit 2 NPHI_C PF08469.5 KII67436.1 - 0.54 10.1 5.9 0.25 11.2 0.5 2.6 3 0 0 3 3 3 0 Nucleoside triphosphatase I C-terminal Collagen PF01391.13 KII67437.1 - 3.1e-08 33.0 26.0 4.1e-08 32.6 18.0 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) COQ7 PF03232.8 KII67438.1 - 3.2e-35 121.1 0.0 3.5e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 zf-C3HC4_3 PF13920.1 KII67440.1 - 3.3e-10 39.4 18.0 4.7e-10 38.9 12.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KII67440.1 - 0.0092 15.9 22.5 0.018 15.0 15.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UPF0547 PF10571.4 KII67440.1 - 0.22 11.2 10.8 2.1 8.1 0.1 2.8 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 Rhodanese PF00581.15 KII67441.1 - 3e-12 46.8 0.0 6.6e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain DUF498 PF04430.9 KII67442.1 - 9.9e-15 54.0 0.0 1.1e-14 53.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) tRNA-synt_1 PF00133.17 KII67444.1 - 2.6e-214 712.6 0.8 4.1e-214 712.0 0.1 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 KII67444.1 - 1.5e-19 70.2 0.2 4.3e-19 68.7 0.0 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KII67444.1 - 4e-16 58.6 7.6 3.3e-06 25.9 0.4 4.3 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 KII67444.1 - 0.011 14.8 0.0 0.029 13.4 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DUF3164 PF11363.3 KII67446.1 - 0.066 12.6 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3164) Bromodomain PF00439.20 KII67448.1 - 1.7e-18 66.2 0.5 1.8e-17 63.0 0.0 2.6 2 0 0 2 2 2 1 Bromodomain WD40 PF00400.27 KII67448.1 - 0.0012 18.6 0.3 0.0012 18.6 0.2 2.2 3 0 0 3 3 3 1 WD domain, G-beta repeat TFIIE_alpha PF02002.12 KII67449.1 - 1.4e-12 47.0 0.5 1.4e-12 47.0 0.3 1.9 2 0 0 2 2 2 1 TFIIE alpha subunit TFIIE-A_C-term PF11521.3 KII67449.1 - 3.3e-06 26.9 8.6 4.1e-06 26.6 4.0 2.6 2 1 0 2 2 2 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.7 KII67449.1 - 0.00018 20.7 1.5 0.00048 19.3 1.0 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding RecO_N_2 PF13114.1 KII67449.1 - 0.042 13.5 0.6 0.23 11.1 0.2 2.2 2 0 0 2 2 2 0 RecO N terminal DUF3371 PF11851.3 KII67449.1 - 0.075 13.7 2.3 0.2 12.3 1.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3371) zf-CHY PF05495.7 KII67449.1 - 0.12 12.5 1.1 0.28 11.3 0.8 1.6 1 0 0 1 1 1 0 CHY zinc finger RRM_1 PF00076.17 KII67450.1 - 0.00018 21.0 0.2 0.93 9.1 0.1 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII67450.1 - 0.026 14.3 0.2 1.5 8.6 0.0 2.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hom_end_hint PF05203.11 KII67450.1 - 6.5 6.4 10.1 11 5.6 7.0 1.4 1 0 0 1 1 1 0 Hom_end-associated Hint AAA_23 PF13476.1 KII67450.1 - 7.8 6.7 19.9 16 5.7 13.8 1.5 1 0 0 1 1 1 0 AAA domain HSP20 PF00011.16 KII67452.1 - 8.3e-23 80.1 1.4 3.1e-13 49.4 0.0 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family RtcR PF06956.6 KII67452.1 - 0.13 11.6 0.1 0.27 10.5 0.0 1.5 1 1 1 2 2 2 0 Regulator of RNA terminal phosphate cyclase HTH_38 PF13936.1 KII67453.1 - 7.2e-07 28.6 0.0 0.0001 21.7 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII67453.1 - 1.5e-06 28.3 0.0 1.7e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII67453.1 - 7.9e-06 25.7 0.1 1.5e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 KII67453.1 - 1.1e-05 24.8 0.0 2.2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.13 KII67453.1 - 0.00067 19.3 0.1 0.00082 19.0 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.11 KII67453.1 - 0.0017 18.0 0.2 0.0021 17.7 0.1 1.1 1 0 0 1 1 1 1 Transposase HTH_Crp_2 PF13545.1 KII67453.1 - 0.0021 17.7 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_40 PF14493.1 KII67453.1 - 0.013 15.7 0.2 0.023 14.8 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_11 PF08279.7 KII67453.1 - 0.022 14.4 0.4 0.037 13.6 0.3 1.4 1 0 0 1 1 1 0 HTH domain HTH_7 PF02796.10 KII67453.1 - 0.041 13.7 1.6 0.13 12.0 0.1 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase Helicase_RecD PF05127.9 KII67453.1 - 0.075 12.6 0.0 0.084 12.4 0.0 1.1 1 0 0 1 1 1 0 Helicase TrmB PF01978.14 KII67453.1 - 0.082 12.6 0.1 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 KII67453.1 - 0.096 12.4 0.2 0.52 10.0 0.1 2.0 1 1 0 1 1 1 0 MarR family HTH_Tnp_1 PF01527.15 KII67453.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Transposase RNA_pol_A_CTD PF03118.10 KII67454.1 - 0.088 12.2 0.4 0.22 10.9 0.1 1.7 1 1 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain DDE_3 PF13358.1 KII67456.1 - 2.4e-11 43.5 0.0 2.8e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Pro-NT_NN PF07421.6 KII67457.1 - 0.51 9.8 3.3 0.44 10.0 0.2 2.2 2 1 1 3 3 3 0 Neurotensin/neuromedin N precursor DDE_3 PF13358.1 KII67459.1 - 0.00031 20.5 0.0 0.00033 20.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease GvpD PF07088.6 KII67462.1 - 0.023 13.0 0.1 0.027 12.7 0.1 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein Cor1 PF04803.7 KII67462.1 - 0.087 12.5 1.1 0.17 11.6 0.8 1.5 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region RPM2 PF08579.6 KII67464.1 - 0.013 15.5 2.8 0.025 14.7 2.0 1.6 1 1 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) BUD22 PF09073.5 KII67468.1 - 0.26 10.3 0.0 0.42 9.6 0.0 1.2 1 0 0 1 1 1 0 BUD22 PRANC PF09372.5 KII67469.1 - 0.0013 18.6 3.9 0.0013 18.6 1.9 1.6 1 1 0 1 1 1 1 PRANC domain PBP_like_2 PF12849.2 KII67469.1 - 0.16 11.3 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 PBP superfamily domain TraF PF13728.1 KII67471.1 - 1.4e-15 57.3 0.0 1.8e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.1 KII67471.1 - 0.0003 20.9 0.5 0.0012 19.0 0.3 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain DUF836 PF05768.9 KII67471.1 - 0.0026 17.9 0.0 0.0034 17.6 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Redoxin PF08534.5 KII67471.1 - 0.0029 17.1 0.0 0.017 14.6 0.0 1.9 1 1 1 2 2 2 1 Redoxin Glutaredoxin PF00462.19 KII67471.1 - 0.026 14.5 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin DSBA PF01323.15 KII67471.1 - 0.028 13.9 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.1 KII67471.1 - 0.033 14.1 0.1 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Thioredoxin PF00085.15 KII67471.1 - 0.046 13.4 0.0 0.06 13.0 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin Thioredoxin_3 PF13192.1 KII67471.1 - 0.053 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain MENTAL PF10457.4 KII67472.1 - 0.43 10.1 3.3 0.35 10.4 1.3 1.6 2 0 0 2 2 2 0 Cholesterol-capturing domain Cache_3 PF14827.1 KII67473.1 - 5.7e-15 55.2 0.0 6.7e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Sensory domain of two-component sensor kinase SPOB_a PF14689.1 KII67474.1 - 1.9e-06 27.3 2.1 4.4e-06 26.1 1.5 1.6 1 0 0 1 1 1 1 Sensor_kinase_SpoOB-type, alpha-helical domain PAS_8 PF13188.1 KII67474.1 - 1.3e-05 24.9 0.0 3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.1 KII67474.1 - 1.7e-05 24.4 0.3 6.6e-05 22.5 0.1 2.0 2 0 0 2 2 2 1 GHKL domain PAS PF00989.19 KII67474.1 - 0.0025 17.5 0.0 0.0082 15.9 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_7 PF12860.2 KII67474.1 - 0.0049 16.8 0.0 0.0097 15.9 0.0 1.6 1 0 0 1 1 1 1 PAS fold HsdM_N PF12161.3 KII67474.1 - 0.0057 17.0 0.0 0.01 16.2 0.0 1.5 1 0 0 1 1 1 1 HsdM N-terminal domain PAS_9 PF13426.1 KII67474.1 - 0.0058 16.9 0.0 0.012 15.9 0.0 1.7 1 1 0 1 1 1 1 PAS domain HATPase_c PF02518.21 KII67474.1 - 0.03 14.0 0.0 0.069 12.8 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.5 KII67474.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 PAS fold Na_sulph_symp PF00939.14 KII67475.1 - 3.1e-75 253.8 12.9 3.8e-75 253.5 9.0 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region PrpF PF04303.8 KII67476.1 - 1.4e-134 448.4 1.3 1.6e-134 448.3 0.9 1.0 1 0 0 1 1 1 1 PrpF protein Pro_racemase PF05544.6 KII67476.1 - 0.0014 17.5 0.1 0.0035 16.2 0.0 1.6 2 0 0 2 2 2 1 Proline racemase LysR_substrate PF03466.15 KII67477.1 - 5.2e-43 146.5 0.0 7.1e-43 146.1 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.22 KII67477.1 - 3.1e-22 78.0 1.5 9.3e-22 76.5 0.1 2.3 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_8 PF02954.14 KII67477.1 - 0.005 16.3 0.1 0.018 14.5 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family PBP_like PF12727.2 KII67477.1 - 0.017 14.1 0.0 0.74 8.7 0.0 2.3 1 1 1 2 2 2 0 PBP superfamily domain HTH_30 PF13556.1 KII67477.1 - 0.063 12.8 0.2 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain Serpin PF00079.15 KII67479.1 - 8.5e-44 150.1 3.6 1e-43 149.8 2.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Snapin_Pallidin PF14712.1 KII67480.1 - 0.057 13.7 3.8 6.6 7.1 0.1 2.6 2 0 0 2 2 2 0 Snapin/Pallidin Phage_int_SAM_2 PF12834.2 KII67480.1 - 0.095 13.0 1.6 12 6.3 0.1 2.6 2 0 0 2 2 2 0 Phage integrase, N-terminal Rtt102p PF09510.5 KII67480.1 - 4.4 7.3 15.8 7.2 6.6 2.3 2.8 2 1 0 2 2 2 0 Rtt102p-like transcription regulator protein RSS_P20 PF11757.3 KII67482.1 - 0.073 13.2 0.1 0.58 10.2 0.0 1.9 1 1 1 2 2 2 0 Suppressor of RNA silencing P21-like Serpin PF00079.15 KII67483.1 - 3e-24 85.8 0.6 3.3e-24 85.7 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII67484.1 - 0.0045 16.1 0.1 0.0047 16.0 0.1 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.21 KII67485.1 - 2.2e-26 92.3 0.1 1.2e-25 89.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII67485.1 - 3e-24 85.5 0.0 5.8e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII67485.1 - 1.5e-07 31.2 0.0 3.5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII67485.1 - 0.00015 21.2 0.0 0.0004 19.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.1 KII67485.1 - 0.014 15.9 0.0 0.04 14.4 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease DDE_Tnp_IS1595 PF12762.2 KII67486.1 - 1.8e-06 27.8 0.0 1.9e-05 24.5 0.0 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain Serpin PF00079.15 KII67487.1 - 5.1e-43 147.6 3.7 5.8e-43 147.4 2.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII67488.1 - 1.2e-42 146.4 4.1 1.3e-42 146.2 2.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RVT_1 PF00078.22 KII67494.1 - 3.7e-18 65.6 0.1 7e-16 58.2 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII67494.1 - 2e-05 24.3 0.0 5.7e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII67494.1 - 3.2e-05 23.6 11.4 0.011 15.6 1.9 2.4 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII67494.1 - 0.0021 18.4 0.1 0.0046 17.4 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII67494.1 - 0.011 15.5 0.0 0.054 13.3 0.0 2.2 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII67494.1 - 0.013 15.1 5.7 0.19 11.3 0.4 2.8 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.9 KII67494.1 - 0.038 13.9 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_6 PF15288.1 KII67494.1 - 0.13 11.9 12.3 0.88 9.2 0.7 2.5 2 0 0 2 2 2 0 Zinc knuckle Beta-Casp PF10996.3 KII67498.1 - 9.4e-30 103.1 0.0 1.9e-29 102.1 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain CPSF73-100_C PF11718.3 KII67498.1 - 7e-20 71.3 2.6 2.3e-19 69.6 1.8 1.8 1 1 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term RMMBL PF07521.7 KII67498.1 - 6.9e-09 35.3 0.0 1.5e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase DRMBL PF07522.9 KII67498.1 - 0.029 14.4 0.0 0.084 12.9 0.0 1.9 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase Glyco_hydro_2_C PF02836.12 KII67499.1 - 0.0028 16.6 0.2 0.014 14.2 0.2 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Dimer_Tnp_hAT PF05699.9 KII67500.1 - 8.2e-05 22.1 0.7 0.00016 21.2 0.5 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Peptidase_M24 PF00557.19 KII67501.1 - 3.7e-23 82.2 0.2 5.1e-23 81.7 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 PLAC8 PF04749.12 KII67502.1 - 3.5e-09 37.1 10.0 4.4e-09 36.8 6.9 1.2 1 0 0 1 1 1 1 PLAC8 family MULE PF10551.4 KII67503.1 - 1.2e-09 38.1 0.0 2.9e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Ldl_recept_a PF00057.13 KII67504.1 - 6.5e-05 22.7 16.7 6.5e-05 22.7 11.6 3.7 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A BNR_2 PF13088.1 KII67504.1 - 0.028 13.7 0.2 0.075 12.3 0.1 1.6 1 1 1 2 2 2 0 BNR repeat-like domain BNR PF02012.15 KII67504.1 - 0.048 13.4 1.6 10 6.4 0.0 3.1 2 0 0 2 2 2 0 BNR/Asp-box repeat Propep_M14 PF02244.11 KII67504.1 - 0.084 12.5 0.2 0.76 9.4 0.0 2.6 3 0 0 3 3 3 0 Carboxypeptidase activation peptide BNR PF02012.15 KII67505.1 - 8e-05 21.9 2.0 1.6 8.8 0.0 3.9 4 0 0 4 4 4 2 BNR/Asp-box repeat MxiM PF11441.3 KII67505.1 - 0.11 12.6 0.1 0.11 12.6 0.1 2.4 3 1 0 3 3 3 0 Pilot protein MxiM BNR PF02012.15 KII67506.1 - 4.6e-05 22.6 0.4 1 9.4 0.0 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_2 PF13088.1 KII67506.1 - 0.0057 15.9 0.0 0.0066 15.7 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain rve PF00665.21 KII67508.1 - 6.7e-20 71.3 0.0 8.4e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII67508.1 - 0.033 13.7 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain BNR PF02012.15 KII67510.1 - 5.4e-05 22.4 7.8 1.1 9.3 0.3 4.2 4 0 0 4 4 4 3 BNR/Asp-box repeat RVT_1 PF00078.22 KII67512.1 - 0.00012 21.4 0.0 0.00025 20.4 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pept_tRNA_hydro PF01195.14 KII67512.1 - 0.11 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase Flavodoxin_2 PF02525.12 KII67515.1 - 1.6e-22 80.0 0.0 1.8e-22 79.8 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.10 KII67515.1 - 0.038 13.5 0.1 0.057 12.9 0.0 1.3 1 1 0 1 1 1 0 NADPH-dependent FMN reductase FragX_IP PF05994.6 KII67517.1 - 6.3e-75 252.5 9.6 7.6e-75 252.2 6.6 1.0 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family Med30 PF11315.3 KII67518.1 - 0.0073 16.4 0.6 0.2 11.7 0.1 2.1 2 0 0 2 2 2 1 Mediator complex subunit 30 BALF1 PF06861.6 KII67518.1 - 0.047 13.1 0.2 0.076 12.4 0.1 1.3 1 0 0 1 1 1 0 BALF1 protein TOM_sub5 PF15178.1 KII67518.1 - 0.14 11.8 0.3 0.49 10.1 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial import receptor subunit TOM5 homolog Mac-1 PF09028.5 KII67520.1 - 0.022 13.5 0.0 0.033 12.9 0.0 1.2 1 0 0 1 1 1 0 Mac 1 DUF3763 PF12592.3 KII67522.1 - 0.07 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3763) Glyco_hydro_85 PF03644.8 KII67523.1 - 0.11 11.5 0.1 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 Serpin PF00079.15 KII67524.1 - 4e-33 115.0 4.7 4.7e-33 114.8 3.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) YoaP PF14268.1 KII67525.1 - 0.095 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 YoaP-like DDE_3 PF13358.1 KII67526.1 - 2.3e-22 79.3 0.0 2.8e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DEAD PF00270.24 KII67527.1 - 2e-16 59.9 0.0 3.3e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KII67527.1 - 0.0021 17.9 0.0 0.0053 16.6 0.0 1.8 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit Sec39 PF08314.6 KII67527.1 - 0.067 11.1 0.1 0.1 10.5 0.0 1.1 1 0 0 1 1 1 0 Secretory pathway protein Sec39 DUF3543 PF12063.3 KII67528.1 - 0.085 12.0 0.0 0.096 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3543) PCNA_N PF00705.13 KII67528.1 - 0.1 12.0 0.1 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain 7tm_1 PF00001.16 KII67530.1 - 2.3e-22 79.3 20.4 3.7e-22 78.6 14.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.4 KII67530.1 - 1.1e-09 37.8 16.8 1.1e-09 37.8 11.7 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx DC_STAMP PF07782.8 KII67530.1 - 0.011 15.4 1.9 0.11 12.0 0.2 2.6 2 0 0 2 2 2 0 DC-STAMP-like protein DUF3481 PF11980.3 KII67530.1 - 0.81 9.5 3.9 2.5 7.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3481) DDE_3 PF13358.1 KII67533.1 - 0.0001 22.0 0.0 0.00012 21.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease 7TM_GPCR_Srw PF10324.4 KII67536.1 - 0.00038 19.6 0.6 0.00043 19.5 0.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF1182 PF06681.8 KII67536.1 - 0.0092 15.2 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1182) 7tm_1 PF00001.16 KII67536.1 - 0.021 13.9 0.9 0.023 13.8 0.2 1.4 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF749 PF05370.6 KII67536.1 - 0.046 13.6 0.2 0.084 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF749) DUF3139 PF11337.3 KII67536.1 - 0.072 13.3 4.5 0.064 13.5 1.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3139) Taeniidae_ag PF05596.6 KII67536.1 - 0.1 12.4 1.2 7.8 6.3 0.1 2.4 2 1 0 2 2 2 0 Taeniidae antigen DUF976 PF06162.7 KII67536.1 - 0.17 11.3 1.8 1.9 7.9 0.2 2.3 2 1 0 2 2 2 0 Caenorhabditis elegans protein of unknown function (DUF976) KLRAQ PF10205.4 KII67537.1 - 1.3e-07 31.6 1.3 1.3e-07 31.6 0.9 3.2 2 1 1 3 3 3 1 Predicted coiled-coil domain-containing protein DUF948 PF06103.6 KII67537.1 - 0.44 10.4 9.4 5.8 6.8 0.1 4.3 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Filament PF00038.16 KII67537.1 - 1.1 8.7 22.6 1.4 8.2 5.5 3.7 3 1 1 4 4 4 0 Intermediate filament protein TMF_TATA_bd PF12325.3 KII67537.1 - 2.5 7.8 18.3 9.2 6.0 1.1 3.5 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4140 PF13600.1 KII67537.1 - 4.5 7.7 5.6 17 5.9 0.0 3.5 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) ACCA PF03255.9 KII67537.1 - 7.5 6.0 9.8 0.32 10.5 0.4 2.9 3 0 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Vfa1 PF08432.5 KII67537.1 - 7.6 6.5 14.3 8.1 6.4 6.5 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RVT_1 PF00078.22 KII67540.1 - 4.1e-10 39.3 0.7 4.7e-08 32.6 0.2 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII67541.1 - 2.2e-15 56.8 0.0 6.1e-15 55.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII67541.1 - 6.6e-05 22.3 0.3 0.003 17.0 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain FliD_C PF07195.7 KII67541.1 - 0.026 13.8 3.9 0.066 12.4 2.7 1.7 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF4635 PF15466.1 KII67541.1 - 0.088 12.1 0.0 1.4 8.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) RVT_1 PF00078.22 KII67542.1 - 8.4e-09 35.0 0.1 1.3e-08 34.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII67543.1 - 1.6e-25 89.5 0.0 3.1e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII67543.1 - 0.0001 21.7 0.6 0.00046 19.6 0.3 2.3 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII67543.1 - 0.029 14.3 0.0 0.067 13.1 0.0 1.6 1 0 0 1 1 1 0 DDE domain DDE_3 PF13358.1 KII67544.1 - 2.3e-23 82.5 0.0 4.8e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease GerE PF00196.14 KII67544.1 - 0.00064 18.9 0.1 0.0015 17.8 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family rve PF00665.21 KII67544.1 - 0.0017 18.4 0.0 0.0029 17.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HTH_28 PF13518.1 KII67544.1 - 0.003 17.5 0.0 0.0066 16.4 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 KII67544.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_29 PF13551.1 KII67544.1 - 0.016 15.3 0.1 0.03 14.4 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_1 PF01527.15 KII67544.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 Transposase HTH_10 PF04967.7 KII67544.1 - 0.067 12.7 0.1 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 HTH DNA binding domain HTH_Tnp_Tc3_2 PF01498.13 KII67544.1 - 0.097 12.7 0.1 0.27 11.3 0.1 1.7 1 0 0 1 1 1 0 Transposase RVT_1 PF00078.22 KII67546.1 - 1.2e-27 96.7 0.2 3.4e-27 95.2 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII67546.1 - 5.3e-25 87.8 0.0 1.5e-24 86.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII67546.1 - 0.00068 19.1 2.4 0.00078 18.9 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain Spuma_A9PTase PF03539.9 KII67546.1 - 0.007 16.2 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) DDE_3 PF13358.1 KII67547.1 - 9e-15 54.6 0.0 4e-14 52.5 0.0 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease Colicin_Pyocin PF01320.13 KII67547.1 - 0.00087 19.1 0.1 0.0022 17.8 0.1 1.7 1 0 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein DUF2024 PF09630.5 KII67547.1 - 0.11 12.2 0.7 7 6.4 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF2024) DDE_3 PF13358.1 KII67548.1 - 0.0048 16.6 0.0 0.0055 16.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-CCHC PF00098.18 KII67549.1 - 0.0002 21.1 1.4 0.0002 21.1 1.0 1.9 3 0 0 3 3 3 1 Zinc knuckle Zn_Tnp_IS91 PF14319.1 KII67549.1 - 0.25 10.8 3.9 0.37 10.3 2.7 1.2 1 0 0 1 1 1 0 Transposase zinc-binding domain RVT_1 PF00078.22 KII67551.1 - 0.0096 15.3 0.0 0.0096 15.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1147 PF06615.6 KII67551.1 - 0.16 11.8 1.1 0.36 10.6 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1147) MULE PF10551.4 KII67552.1 - 9.1e-10 38.5 0.1 1.7e-09 37.7 0.1 1.5 1 0 0 1 1 1 1 MULE transposase domain RVP PF00077.15 KII67554.1 - 0.0086 15.9 0.0 0.017 15.0 0.0 1.5 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII67554.1 - 0.012 16.0 0.0 0.024 15.1 0.0 1.6 1 1 0 1 1 1 0 Aspartyl protease Peptidase_A3 PF02160.10 KII67554.1 - 0.071 12.6 0.1 0.095 12.2 0.0 1.2 1 0 0 1 1 1 0 Cauliflower mosaic virus peptidase (A3) rve PF00665.21 KII67555.1 - 2.6e-28 98.5 0.0 4.8e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII67555.1 - 0.0056 16.1 0.0 0.043 13.3 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.5 KII67555.1 - 0.018 14.4 0.4 0.042 13.2 0.3 1.7 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger Serpin PF00079.15 KII67556.1 - 4e-42 144.6 4.7 4.5e-42 144.5 3.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Apc15p PF05841.6 KII67560.1 - 0.21 12.3 2.2 0.28 11.9 1.5 1.3 1 0 0 1 1 1 0 Apc15p protein DUF735 PF05246.6 KII67561.1 - 0.024 14.3 0.1 0.032 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF735) AMP-binding PF00501.23 KII67562.1 - 9.2e-72 241.7 0.0 1.2e-71 241.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.23 KII67563.1 - 1.6e-35 122.3 0.0 2.1e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Spermine_synth PF01564.12 KII67564.1 - 6.7e-46 156.2 1.7 7.9e-46 155.9 1.2 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 KII67564.1 - 0.003 17.1 0.1 0.0079 15.7 0.1 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 KII67564.1 - 0.13 12.3 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Str_synth PF03088.11 KII67565.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Strictosidine synthase DUF3822 PF12864.2 KII67565.1 - 0.13 11.4 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3822) DUF3289 PF11692.3 KII67566.1 - 0.003 16.8 0.1 0.0036 16.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3289) DUF4371 PF14291.1 KII67567.1 - 0.021 14.3 0.1 0.025 14.1 0.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4371) HSP70 PF00012.15 KII67568.1 - 1.3e-101 340.4 0.0 2e-101 339.8 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KII67568.1 - 0.00023 19.8 0.0 0.0004 19.0 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.1 KII67568.1 - 0.0035 17.1 1.5 0.049 13.4 1.1 2.4 1 1 0 1 1 1 1 Cell division protein FtsA TFIIB PF00382.14 KII67569.1 - 1e-05 25.2 0.0 2.6e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Transcription factor TFIIB repeat BRF1 PF07741.8 KII67569.1 - 0.00011 22.3 0.7 0.0004 20.5 0.5 2.0 1 0 0 1 1 1 1 Brf1-like TBP-binding domain FadA PF09403.5 KII67569.1 - 0.037 14.0 1.9 1.9 8.5 0.0 2.5 2 0 0 2 2 2 0 Adhesion protein FadA PhoU PF01895.14 KII67569.1 - 0.055 13.9 0.7 0.18 12.2 0.5 1.9 1 0 0 1 1 1 0 PhoU domain AT_hook PF02178.14 KII67569.1 - 0.12 12.0 6.7 0.42 10.4 4.6 1.9 1 0 0 1 1 1 0 AT hook motif DDE_Tnp_IS1595 PF12762.2 KII67571.1 - 1.2e-06 28.4 0.0 1.6e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain FlgN PF05130.7 KII67572.1 - 0.083 13.1 0.9 0.11 12.7 0.7 1.1 1 0 0 1 1 1 0 FlgN protein UPF0104 PF03706.8 KII67572.1 - 0.24 10.6 3.7 0.31 10.2 2.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) Nup54 PF13874.1 KII67572.1 - 2 8.0 4.8 2.6 7.6 3.3 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DNA_pol_B PF00136.16 KII67574.1 - 3.8e-08 32.5 0.0 1.6e-07 30.5 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase family B Oxygenase-NA PF09859.4 KII67574.1 - 0.14 11.4 0.0 0.34 10.2 0.0 1.6 2 0 0 2 2 2 0 Oxygenase, catalysing oxidative methylation of damaged DNA FLYWCH PF04500.11 KII67577.1 - 0.00024 20.9 3.0 0.00053 19.8 2.1 1.6 1 1 0 1 1 1 1 FLYWCH zinc finger domain RasGEF_N PF00618.15 KII67578.1 - 0.015 15.3 0.2 0.03 14.4 0.2 1.4 1 0 0 1 1 1 0 RasGEF N-terminal motif ATG27 PF09451.5 KII67578.1 - 0.054 12.7 0.1 0.12 11.5 0.0 1.6 2 0 0 2 2 2 0 Autophagy-related protein 27 Porphobil_deam PF01379.15 KII67579.1 - 2.2e-27 95.4 0.4 6.9e-27 93.7 0.3 1.8 1 1 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 KII67579.1 - 2.9e-10 40.1 0.1 6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Pox_P4A PF03395.9 KII67579.1 - 0.068 10.7 0.0 0.089 10.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus P4A protein PLAC8 PF04749.12 KII67580.1 - 8.7e-16 58.4 17.3 8.7e-16 58.4 12.0 1.3 1 1 0 1 1 1 1 PLAC8 family Methyltransf_8 PF05148.10 KII67581.1 - 3e-70 236.2 0.2 3.6e-70 236.0 0.1 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 KII67581.1 - 6.2e-07 29.8 0.0 1.3e-05 25.5 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII67581.1 - 0.0048 16.5 0.0 1.3 8.6 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.9 KII67581.1 - 0.0058 16.0 0.0 0.12 11.7 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase small domain DUF4452 PF14618.1 KII67581.1 - 0.013 15.3 0.5 0.02 14.6 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4452) Methyltransf_23 PF13489.1 KII67581.1 - 0.016 14.8 0.0 0.028 14.1 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain GCN5L1 PF06320.8 KII67581.1 - 0.14 11.9 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) BSD PF03909.12 KII67581.1 - 0.2 11.4 1.1 4.1 7.2 0.1 2.4 1 1 1 2 2 2 0 BSD domain zf-C5HC2 PF02928.11 KII67583.1 - 0.011 15.8 0.1 0.017 15.2 0.1 1.3 1 0 0 1 1 1 0 C5HC2 zinc finger RNA_pol_Rpb4 PF03874.11 KII67583.1 - 0.028 14.4 2.6 0.076 13.0 1.8 1.8 1 1 0 1 1 1 0 RNA polymerase Rpb4 Herpes_UL52 PF03121.10 KII67584.1 - 3.4e-11 42.6 1.3 3.4e-11 42.6 0.9 2.1 3 0 0 3 3 3 1 Herpesviridae UL52/UL70 DNA primase DNA_primase_S PF01896.14 KII67584.1 - 0.00026 20.8 0.8 0.0005 19.8 0.6 1.5 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit Pkinase PF00069.20 KII67585.1 - 1.1e-11 44.3 0.1 1.1e-10 41.1 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain EcKinase PF02958.15 KII67585.1 - 0.0013 17.9 0.0 0.0037 16.4 0.1 1.6 2 0 0 2 2 2 1 Ecdysteroid kinase Pkinase_Tyr PF07714.12 KII67585.1 - 0.0076 15.3 0.1 0.091 11.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Far-17a_AIG1 PF04750.9 KII67586.1 - 4.2e-25 88.0 12.4 6e-25 87.5 8.6 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Cytochrome-c551 PF10643.4 KII67586.1 - 9 5.5 8.4 1.7 7.8 0.6 2.1 1 1 1 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 Laminin_G_3 PF13385.1 KII67588.1 - 1.2e-26 93.8 0.0 7.1e-09 36.0 0.0 4.1 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily Kunitz_BPTI PF00014.18 KII67588.1 - 9.4e-16 57.7 0.8 2.8e-15 56.2 0.6 1.9 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain CBM_14 PF01607.19 KII67588.1 - 1.3e-08 34.6 0.2 4.4e-08 32.9 0.1 2.0 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain TSP_1 PF00090.14 KII67588.1 - 0.42 10.7 12.3 0.014 15.4 3.1 2.6 3 0 0 3 3 3 0 Thrombospondin type 1 domain DDE_3 PF13358.1 KII67589.1 - 7.6e-06 25.7 0.1 1.2e-05 25.1 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease PPR PF01535.15 KII67589.1 - 0.095 12.7 0.2 18 5.5 0.0 2.5 2 0 0 2 2 2 0 PPR repeat DUF2491 PF10679.4 KII67589.1 - 0.11 11.4 0.1 0.14 11.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2491) Mito_carr PF00153.22 KII67591.1 - 5.1e-63 208.8 1.1 4.4e-22 77.5 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF2007 PF09413.5 KII67591.1 - 0.12 12.1 0.0 0.45 10.3 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF2007) DegS PF05384.6 KII67592.1 - 0.0061 15.7 1.3 0.023 13.9 0.2 1.9 1 1 1 2 2 2 1 Sensor protein DegS AAA_27 PF13514.1 KII67592.1 - 0.0081 13.9 0.0 0.0081 13.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain DUF342 PF03961.8 KII67592.1 - 0.022 13.1 0.3 0.024 13.0 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) GAS PF13851.1 KII67592.1 - 0.032 13.4 0.6 0.041 13.0 0.4 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF2312 PF10073.4 KII67592.1 - 0.059 12.7 0.4 0.12 11.7 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Cluap1 PF10234.4 KII67592.1 - 0.074 12.2 2.3 0.082 12.1 1.6 1.3 1 1 0 1 1 1 0 Clusterin-associated protein-1 SIS PF01380.17 KII67594.1 - 2.1e-48 163.2 0.3 1.1e-28 99.5 0.0 2.5 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 KII67594.1 - 2.4e-14 52.8 0.1 4.8e-14 51.8 0.1 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.1 KII67594.1 - 2.5e-14 53.3 0.0 4.6e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 KII67594.1 - 4.1e-10 39.4 0.0 1.1e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 KII67594.1 - 9.2e-07 27.8 0.1 1.8e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 KII67594.1 - 0.03 14.0 0.0 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 SIS domain DUF1673 PF07895.6 KII67595.1 - 0.038 13.5 0.5 0.039 13.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Transglut_N PF00868.15 KII67597.1 - 0.00023 21.1 0.0 0.00048 20.1 0.0 1.5 1 1 0 1 1 1 1 Transglutaminase family Glyco_transf_10 PF00852.14 KII67601.1 - 4.4e-43 147.1 5.8 5e-43 147.0 4.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) DUF2079 PF09852.4 KII67603.1 - 0.051 12.3 0.4 0.058 12.1 0.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) rRNA_methylase PF06962.7 KII67604.1 - 0.037 13.7 0.1 0.051 13.2 0.1 1.3 1 0 0 1 1 1 0 Putative rRNA methylase PWI PF01480.12 KII67605.1 - 2.7e-27 94.6 0.0 4.9e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 PWI domain Tyr_Deacylase PF02580.11 KII67606.1 - 1.3e-34 119.2 0.1 1.4e-34 119.1 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Streptin-Immun PF11083.3 KII67606.1 - 0.018 15.0 0.7 0.025 14.5 0.5 1.2 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein RrnaAD PF00398.15 KII67608.1 - 2.8e-58 197.0 0.0 3.5e-58 196.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 KII67608.1 - 2.5e-10 40.3 0.0 3.4e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII67608.1 - 1.8e-08 34.0 0.0 2.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KII67608.1 - 2.1e-06 28.3 0.0 3.3e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KII67608.1 - 5.3e-06 25.9 0.0 8e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 KII67608.1 - 1.9e-05 25.0 0.0 3.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII67608.1 - 2.8e-05 24.5 0.0 5.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 KII67608.1 - 9.7e-05 21.4 0.0 0.00015 20.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 KII67608.1 - 0.0003 20.5 0.0 0.00041 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KII67608.1 - 0.0004 19.5 0.0 0.00056 19.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 KII67608.1 - 0.0013 19.0 0.0 0.0023 18.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 KII67608.1 - 0.0025 17.2 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) PCMT PF01135.14 KII67608.1 - 0.01 15.4 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.7 KII67608.1 - 0.039 12.8 0.0 0.056 12.3 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase TrkA_N PF02254.13 KII67608.1 - 0.039 13.9 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Spermine_synth PF01564.12 KII67608.1 - 0.04 12.8 0.0 0.054 12.4 0.0 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase DUF43 PF01861.11 KII67608.1 - 0.092 11.7 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF43 Rhomboid PF01694.17 KII67609.1 - 0.072 13.1 7.9 0.091 12.7 5.5 1.1 1 0 0 1 1 1 0 Rhomboid family DUF1614 PF07758.6 KII67609.1 - 0.077 12.7 2.4 0.11 12.2 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1614) DUF4134 PF13572.1 KII67609.1 - 0.52 10.4 4.8 2.7 8.1 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4134) DUF996 PF06195.8 KII67609.1 - 1.1 9.3 8.7 3.8 7.4 6.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF996) DUF1461 PF07314.6 KII67609.1 - 1.3 8.7 8.5 0.15 11.7 2.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) DUF3989 PF13150.1 KII67609.1 - 1.4 8.3 6.5 5.3 6.5 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3989) MARVEL PF01284.18 KII67609.1 - 4.6 7.0 10.8 13 5.5 7.3 1.8 1 1 1 2 2 2 0 Membrane-associating domain Pkinase PF00069.20 KII67610.1 - 2.2e-51 174.4 0.0 2.9e-51 174.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII67610.1 - 4.2e-23 81.7 0.0 7.2e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII67610.1 - 1.4e-05 24.2 0.0 5.5e-05 22.2 0.0 1.7 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 KII67610.1 - 0.0072 16.0 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Actin PF00022.14 KII67611.1 - 1.8e-88 296.6 0.0 6.7e-86 288.1 0.0 2.2 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 KII67611.1 - 0.019 13.5 1.5 0.4 9.2 0.0 2.8 3 0 0 3 3 3 0 MreB/Mbl protein DDE_3 PF13358.1 KII67612.1 - 0.00011 21.9 0.9 0.00018 21.2 0.6 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease MSC PF09402.5 KII67613.1 - 0.064 11.9 0.8 0.12 11.0 0.1 1.7 1 1 1 2 2 2 0 Man1-Src1p-C-terminal domain MIT PF04212.13 KII67615.1 - 0.088 12.7 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain ATP-synt_E_2 PF08112.6 KII67615.1 - 1.4 8.9 8.2 1.8 8.6 0.5 3.2 2 2 0 2 2 2 0 ATP synthase epsilon subunit CLTH PF10607.4 KII67616.1 - 0.18 11.4 3.5 2 8.1 0.2 2.2 2 0 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain RelB_N PF12910.2 KII67619.1 - 0.079 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Antitoxin of toxin-antitoxin stability system N-terminal Plasmodium_HRP PF05403.6 KII67627.1 - 5.4 6.5 33.4 7.3 6.1 23.1 1.2 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) Vps51 PF08700.6 KII67629.1 - 0.026 14.3 2.8 0.026 14.3 1.9 2.5 3 1 0 3 3 3 0 Vps51/Vps67 DUF16 PF01519.11 KII67629.1 - 0.033 14.3 6.9 0.037 14.2 3.9 1.9 2 1 0 2 2 2 0 Protein of unknown function DUF16 Mitofilin PF09731.4 KII67629.1 - 0.11 11.0 3.9 0.18 10.4 2.7 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein GIT1_C PF12205.3 KII67629.1 - 0.16 11.8 2.4 1.4 8.8 0.3 2.9 2 2 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF1664 PF07889.7 KII67629.1 - 1.1 9.0 4.6 14 5.5 0.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4163 PF13739.1 KII67629.1 - 1.4 9.7 7.4 3.8 8.3 5.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4163) DDE_3 PF13358.1 KII67632.1 - 1.1e-06 28.4 0.0 1.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Nucleopor_Nup85 PF07575.8 KII67632.1 - 0.082 11.0 0.0 0.085 11.0 0.0 1.1 1 0 0 1 1 1 0 Nup85 Nucleoporin Ndr PF03096.9 KII67633.1 - 8e-14 50.7 0.0 9.7e-14 50.5 0.0 1.0 1 0 0 1 1 1 1 Ndr family Prenyltrans PF00432.16 KII67634.1 - 2e-38 129.5 5.2 7.4e-12 44.6 0.1 4.0 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 KII67634.1 - 1.5e-21 76.9 0.0 1.4e-10 41.5 0.0 2.5 1 1 2 3 3 3 3 Prenyltransferase-like LEF-8 PF04941.7 KII67634.1 - 0.012 13.3 0.0 0.015 12.9 0.0 1.1 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) Prenyltrans_1 PF13243.1 KII67634.1 - 0.09 12.7 0.0 7.2 6.6 0.0 2.7 2 1 1 3 3 3 0 Prenyltransferase-like Calx-beta PF03160.9 KII67636.1 - 0.047 13.6 0.1 0.082 12.8 0.1 1.5 1 1 0 1 1 1 0 Calx-beta domain Minor_capsid_3 PF12691.2 KII67637.1 - 0.085 12.5 0.1 0.089 12.4 0.0 1.3 1 1 0 1 1 1 0 Minor capsid protein from bacteriophage RRM_1 PF00076.17 KII67638.1 - 6.8e-08 32.0 0.0 0.013 15.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII67638.1 - 4.8e-06 26.4 0.0 0.12 12.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pyr_redox_3 PF13738.1 KII67639.1 - 0.0029 17.6 0.0 0.0029 17.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KII67639.1 - 0.0061 16.3 0.2 0.024 14.4 0.0 1.8 1 1 1 2 2 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 KII67639.1 - 0.0065 15.5 0.0 0.0089 15.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 KII67639.1 - 0.0098 15.0 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 KII67639.1 - 0.011 15.6 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KII67639.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain JAB PF01398.16 KII67639.1 - 0.092 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease LUC7 PF03194.10 KII67640.1 - 5.9e-61 206.2 4.0 5.9e-61 206.2 2.8 1.5 2 0 0 2 2 2 1 LUC7 N_terminus DUF4423 PF14394.1 KII67640.1 - 0.026 14.0 1.7 2.8 7.4 0.2 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4423) DUF4175 PF13779.1 KII67640.1 - 4.4 4.8 21.0 17 2.9 14.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4175) Macoilin PF09726.4 KII67640.1 - 4.6 5.4 21.2 5.6 5.1 14.7 1.1 1 0 0 1 1 1 0 Transmembrane protein 3HCDH_N PF02737.13 KII67641.1 - 4.8e-38 130.6 0.0 7.1e-38 130.0 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 KII67641.1 - 3.7e-26 91.3 0.0 1.4e-15 57.4 0.0 2.5 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH PF00378.15 KII67641.1 - 1.3e-21 76.8 0.0 5.5e-21 74.7 0.0 2.0 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Semialdhyde_dh PF01118.19 KII67641.1 - 0.001 19.3 0.0 0.0075 16.5 0.0 2.3 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 KII67641.1 - 0.052 13.2 0.1 0.21 11.3 0.0 1.9 1 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HbrB PF08539.6 KII67642.1 - 0.0037 17.1 0.1 0.0049 16.7 0.0 1.3 1 0 0 1 1 1 1 HbrB-like YscK PF06578.7 KII67642.1 - 0.053 12.9 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) KA1 PF02149.14 KII67643.1 - 0.045 13.1 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 Kinase associated domain 1 Pkinase PF00069.20 KII67644.1 - 2.3e-39 135.1 0.0 2.7e-39 134.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII67644.1 - 7.2e-20 71.1 0.0 8.5e-20 70.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII67644.1 - 1.5e-07 30.6 0.0 1.9e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 KII67644.1 - 0.00022 20.6 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 KII67644.1 - 0.0025 17.5 0.0 0.0037 17.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KII67644.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DDE_3 PF13358.1 KII67649.1 - 1.2e-13 51.0 0.1 2e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease CENP-B_N PF04218.8 KII67649.1 - 0.00057 19.2 0.0 0.0013 18.1 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.1 KII67649.1 - 0.0017 18.3 0.0 0.021 14.8 0.0 2.2 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 KII67649.1 - 0.0022 17.5 0.1 0.016 14.8 0.0 2.4 2 1 0 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.1 KII67649.1 - 0.013 14.8 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_33 PF13592.1 KII67649.1 - 0.015 14.8 0.0 0.049 13.1 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn helix Sigma70_r4 PF04545.11 KII67649.1 - 0.016 14.4 0.0 0.037 13.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 MarR_2 PF12802.2 KII67649.1 - 0.023 14.3 0.0 0.063 12.9 0.0 1.7 1 1 0 1 1 1 0 MarR family HTH_psq PF05225.11 KII67649.1 - 0.046 13.2 0.0 0.09 12.3 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain DUF1454 PF07305.7 KII67650.1 - 0.04 13.0 0.0 0.05 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) RRM_1 PF00076.17 KII67651.1 - 1.2e-14 53.6 0.0 1.6e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII67651.1 - 7.2e-11 41.9 0.0 1e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII67651.1 - 3.7e-09 36.3 0.0 5.2e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KII67651.1 - 0.076 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 DDE_Tnp_IS1595 PF12762.2 KII67652.1 - 4.1e-07 29.9 0.0 5.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain RB_B PF01857.15 KII67653.1 - 1.8e-30 105.2 3.5 6.6e-30 103.3 2.4 2.0 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain RB_A PF01858.12 KII67653.1 - 9.8e-26 90.6 2.9 9.8e-26 90.6 2.0 3.2 2 1 1 3 3 3 1 Retinoblastoma-associated protein A domain DUF3452 PF11934.3 KII67653.1 - 2.9e-12 46.1 4.5 2.9e-12 46.1 3.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3452) DUF3091 PF11291.3 KII67653.1 - 0.0052 16.7 0.3 0.044 13.7 0.2 2.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3091) Cbl_N PF02262.11 KII67653.1 - 7.4 6.2 11.4 11 5.7 0.7 3.9 3 2 2 5 5 5 0 CBL proto-oncogene N-terminal domain 1 Cofilin_ADF PF00241.15 KII67654.1 - 4.1e-10 39.6 0.0 5.2e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Apc4_WD40 PF12894.2 KII67655.1 - 0.00052 19.4 0.1 5 6.7 0.0 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 KII67655.1 - 0.0021 17.8 2.0 2 8.4 0.0 5.1 6 1 0 6 6 6 1 WD domain, G-beta repeat DUF4221 PF13970.1 KII67655.1 - 0.021 14.1 0.9 0.11 11.7 0.1 2.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4221) Cnd2 PF05786.9 KII67655.1 - 0.19 10.2 0.2 0.24 9.8 0.1 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 Pkinase_C PF00433.19 KII67656.1 - 0.002 18.5 0.1 0.0032 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase C terminal domain Pkinase PF00069.20 KII67656.1 - 0.019 14.1 0.0 0.023 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain UPF0254 PF06787.6 KII67656.1 - 0.094 12.2 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) RRM_1 PF00076.17 KII67657.1 - 4.5e-15 55.0 0.3 1.6e-06 27.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII67657.1 - 6.8e-10 38.6 0.2 7.5e-07 28.8 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII67657.1 - 6.3e-09 35.6 0.1 0.0026 17.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) MULE PF10551.4 KII67659.1 - 0.00012 22.2 0.0 0.00018 21.5 0.0 1.2 1 0 0 1 1 1 1 MULE transposase domain TEBP_beta PF07404.6 KII67659.1 - 0.14 11.2 0.1 0.14 11.2 0.1 1.1 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) V-ATPase_H_N PF03224.9 KII67660.1 - 1.5e-06 27.5 0.8 1.6e-06 27.4 0.5 1.0 1 0 0 1 1 1 1 V-ATPase subunit H ER PF01133.12 KII67660.1 - 0.23 11.1 1.3 3 7.6 0.1 2.1 2 0 0 2 2 2 0 Enhancer of rudimentary Peroxin-22 PF12827.2 KII67661.1 - 0.21 11.2 2.8 0.48 10.1 0.5 2.0 1 1 1 2 2 2 0 Peroxisomal biogenesis protein family PAS_3 PF08447.6 KII67662.1 - 3.1e-09 36.8 0.0 5.2e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 PAS fold HLH PF00010.21 KII67662.1 - 5.6e-09 35.5 2.1 1e-08 34.7 1.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.19 KII67662.1 - 0.005 16.6 0.0 0.041 13.6 0.0 2.5 3 0 0 3 3 3 1 PAS fold HTH_Tnp_Tc3_2 PF01498.13 KII67664.1 - 1.9e-07 31.0 0.1 1.6e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.1 KII67664.1 - 0.0042 16.6 0.0 0.0084 15.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_IS630 PF01710.11 KII67664.1 - 0.0073 15.9 1.7 1.1 8.9 0.2 2.2 1 1 1 2 2 2 2 Transposase HTH_29 PF13551.1 KII67664.1 - 0.021 14.9 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_28 PF13518.1 KII67664.1 - 0.034 14.1 0.1 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_32 PF13565.1 KII67664.1 - 0.035 14.9 0.0 0.064 14.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Tn7_Tnp_TnsA_C PF08721.6 KII67664.1 - 0.041 13.9 0.4 1.3 9.1 0.0 2.3 1 1 1 2 2 2 0 TnsA endonuclease C terminal PIF1 PF05970.9 KII67665.1 - 3.7e-31 108.3 0.5 9.4e-31 107.0 0.3 1.6 1 1 0 1 1 1 1 PIF1-like helicase Glyco_hydro_47 PF01532.15 KII67666.1 - 2.8e-24 85.6 0.0 3.1e-24 85.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DDE_Tnp_IS1595 PF12762.2 KII67667.1 - 0.048 13.5 0.0 0.13 12.1 0.0 1.9 1 1 0 1 1 1 0 ISXO2-like transposase domain HTH_DeoR PF08220.7 KII67668.1 - 0.004 16.6 0.5 0.006 16.0 0.3 1.3 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII67668.1 - 0.0048 16.9 1.2 0.007 16.4 0.8 1.2 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.1 KII67668.1 - 0.11 12.2 0.2 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Thiolase_C PF02803.13 KII67669.1 - 8.4e-27 93.0 0.0 1.4e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 KII67669.1 - 8.4e-16 57.7 0.1 1.5e-15 56.8 0.1 1.5 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 KII67670.1 - 2.8e-18 65.5 0.0 4.1e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 KII67670.1 - 5.9e-12 45.1 2.1 1.3e-11 44.0 0.2 2.2 2 1 0 2 2 2 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 KII67670.1 - 5.8e-05 22.6 0.7 8.5e-05 22.1 0.1 1.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 KII67670.1 - 0.0011 18.5 0.1 0.019 14.5 0.1 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACT_6 PF13740.1 KII67670.1 - 0.056 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 ACT domain PRP38 PF03371.10 KII67670.1 - 0.067 12.8 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 PRP38 family DUF1604 PF07713.8 KII67671.1 - 3.5e-32 110.0 2.9 3.5e-32 110.0 2.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.18 KII67671.1 - 6e-05 22.7 0.6 0.00017 21.2 0.0 2.1 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.2 KII67671.1 - 0.0034 17.1 0.5 0.022 14.6 0.0 2.7 2 1 0 2 2 2 1 DExH-box splicing factor binding site CH PF00307.26 KII67672.1 - 4.1e-36 123.3 6.5 3.2e-17 62.5 0.2 3.6 4 0 0 4 4 4 3 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KII67672.1 - 1.4e-13 50.2 2.4 0.003 17.1 0.0 3.7 3 1 0 3 3 3 3 CAMSAP CH domain Filamin PF00630.14 KII67672.1 - 0.00058 20.3 0.0 0.0014 19.1 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat Filamin PF00630.14 KII67673.1 - 9e-27 93.5 2.7 1.7e-08 34.9 0.0 4.1 4 0 0 4 4 4 4 Filamin/ABP280 repeat PapC_N PF13954.1 KII67673.1 - 0.019 14.5 0.1 0.038 13.5 0.1 1.4 1 0 0 1 1 1 0 PapC N-terminal domain RCC1 PF00415.13 KII67674.1 - 8.1e-11 41.9 0.0 0.00016 21.8 0.0 2.7 2 1 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KII67674.1 - 6.8e-06 25.5 0.1 0.00081 18.9 0.0 3.1 2 1 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KII67675.1 - 2.7e-08 33.1 1.3 0.01 15.4 0.0 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 KII67675.1 - 6e-08 32.7 4.7 0.0065 16.6 1.3 3.2 2 1 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat Mur_ligase_M PF08245.7 KII67676.1 - 5.9e-11 42.7 0.6 1.6e-10 41.3 0.4 1.7 1 1 0 1 1 1 1 Mur ligase middle domain ATS3 PF06232.6 KII67676.1 - 0.063 12.8 0.2 6.4 6.3 0.0 2.3 2 0 0 2 2 2 0 Embryo-specific protein 3, (ATS3) Mur_ligase_C PF02875.16 KII67676.1 - 0.092 12.7 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Syntaxin-6_N PF09177.6 KII67678.1 - 0.013 15.8 0.2 0.02 15.2 0.1 1.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Transposase_22 PF02994.9 KII67678.1 - 0.015 13.7 1.6 0.014 13.8 1.1 1.2 1 0 0 1 1 1 0 L1 transposable element TMF_DNA_bd PF12329.3 KII67678.1 - 0.018 14.8 0.7 0.032 14.0 0.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.3 KII67678.1 - 0.041 13.7 0.7 0.066 13.1 0.4 1.4 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding IncA PF04156.9 KII67678.1 - 0.12 11.9 1.2 0.12 11.9 0.8 1.1 1 0 0 1 1 1 0 IncA protein Laminin_II PF06009.7 KII67678.1 - 0.13 12.0 1.3 0.17 11.6 0.9 1.2 1 0 0 1 1 1 0 Laminin Domain II Cortex-I_coil PF09304.5 KII67678.1 - 0.15 12.0 3.0 0.18 11.8 1.9 1.3 1 1 0 1 1 1 0 Cortexillin I, coiled coil CENP-F_leu_zip PF10473.4 KII67678.1 - 0.17 11.7 2.9 0.16 11.8 1.2 1.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1077 PF06417.7 KII67679.1 - 8e-25 86.6 0.1 9.8e-25 86.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) SPC25 PF06703.6 KII67682.1 - 8.9e-18 64.3 0.0 9.5e-18 64.2 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF3278 PF11683.3 KII67682.1 - 0.043 13.8 0.2 0.058 13.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) RICTOR_V PF14668.1 KII67682.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 PGG PF13962.1 KII67682.1 - 0.21 11.2 1.4 0.33 10.5 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function CBM_21 PF03370.8 KII67687.1 - 3.4e-25 88.2 3.6 5.3e-25 87.5 2.5 1.3 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit CBM_25 PF03423.8 KII67687.1 - 0.0037 17.3 0.9 0.0068 16.4 0.6 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain (family 25) MAM33 PF02330.11 KII67688.1 - 4.7e-10 39.5 2.2 3.2e-09 36.8 1.5 2.2 1 1 0 1 1 1 1 Mitochondrial glycoprotein DUF2880 PF11082.3 KII67688.1 - 0.066 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2880) Amastin PF07344.6 KII67689.1 - 0.19 11.2 6.5 0.24 11.0 4.1 1.5 1 1 0 1 1 1 0 Amastin surface glycoprotein MARVEL PF01284.18 KII67689.1 - 2 8.2 12.5 0.25 11.1 2.9 2.1 1 1 0 2 2 2 0 Membrane-associating domain SNARE PF05739.14 KII67690.1 - 7.4e-17 60.7 4.9 7.4e-17 60.7 3.4 2.1 3 0 0 3 3 2 1 SNARE domain Syntaxin_2 PF14523.1 KII67690.1 - 0.00035 20.5 12.0 0.0027 17.6 1.6 3.0 1 1 2 3 3 3 1 Syntaxin-like protein Synaptobrevin PF00957.16 KII67690.1 - 0.0031 17.0 3.0 0.0031 17.0 2.1 2.0 2 1 0 2 2 2 1 Synaptobrevin DUF805 PF05656.9 KII67690.1 - 0.0093 15.7 0.6 0.013 15.3 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF805) Rifin_STEVOR PF02009.11 KII67690.1 - 0.01 15.5 2.9 0.013 15.1 2.0 1.2 1 0 0 1 1 1 0 Rifin/stevor family GET2 PF08690.5 KII67690.1 - 0.017 14.3 0.6 0.023 13.9 0.4 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Phospholamban PF04272.9 KII67690.1 - 0.017 14.5 0.7 0.039 13.3 0.5 1.6 1 0 0 1 1 1 0 Phospholamban Vac_Fusion PF02346.11 KII67690.1 - 0.023 14.1 3.4 1.2 8.6 0.1 2.4 2 0 0 2 2 2 0 Chordopoxvirus fusion protein Laminin_II PF06009.7 KII67690.1 - 0.033 13.9 4.6 0.079 12.7 0.5 2.1 2 0 0 2 2 2 0 Laminin Domain II DUF912 PF06024.7 KII67690.1 - 0.046 13.7 1.4 0.059 13.4 0.3 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ATG16 PF08614.6 KII67690.1 - 0.065 13.0 7.3 0.091 12.5 5.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CLCA_N PF08434.6 KII67690.1 - 0.071 12.3 1.6 1.2 8.3 0.2 2.1 1 1 1 2 2 2 0 Calcium-activated chloride channel Med28 PF11594.3 KII67690.1 - 0.094 12.9 3.9 0.39 10.9 2.7 1.9 1 1 0 1 1 1 0 Mediator complex subunit 28 RGCC PF15151.1 KII67690.1 - 0.11 12.9 1.1 7.2 7.0 0.2 2.2 2 0 0 2 2 2 0 Response gene to complement 32 protein family DUF3899 PF13038.1 KII67690.1 - 0.12 12.5 3.6 7 6.8 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF2077 PF09850.4 KII67690.1 - 0.15 11.4 0.6 2.3 7.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2077) Prominin PF05478.6 KII67690.1 - 0.19 9.2 5.6 0.37 8.2 3.9 1.4 1 1 0 1 1 1 0 Prominin MCPsignal PF00015.16 KII67690.1 - 0.23 10.9 7.9 0.074 12.5 2.3 1.9 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF106 PF01956.11 KII67690.1 - 0.31 10.5 2.3 2 7.9 1.6 2.2 1 1 0 1 1 1 0 Integral membrane protein DUF106 DASH_Dad4 PF08650.5 KII67690.1 - 0.5 10.3 4.1 9.9 6.1 0.3 2.3 2 1 0 2 2 2 0 DASH complex subunit Dad4 AKNA PF12443.3 KII67690.1 - 0.5 10.4 3.4 0.48 10.4 0.3 2.3 1 1 1 2 2 2 0 AT-hook-containing transcription factor DASH_Duo1 PF08651.5 KII67690.1 - 0.6 9.7 5.8 2.2 7.9 0.4 2.7 2 1 0 2 2 2 0 DASH complex subunit Duo1 Atg14 PF10186.4 KII67690.1 - 0.9 8.4 8.3 2.1 7.2 1.7 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 TMCO5 PF14992.1 KII67690.1 - 1.2 8.2 17.6 7.5 5.5 12.2 2.2 1 1 0 1 1 1 0 TMCO5 family Cauli_AT PF03233.8 KII67690.1 - 1.8 8.2 5.8 1.6 8.4 2.9 1.6 1 1 1 2 2 2 0 Aphid transmission protein DUF745 PF05335.8 KII67690.1 - 1.9 7.9 8.3 1.8 8.0 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Tweety PF04906.8 KII67690.1 - 1.9 6.8 7.4 11 4.2 4.9 2.0 1 1 0 1 1 1 0 Tweety MIF4G_like_2 PF09090.6 KII67690.1 - 1.9 7.6 9.2 3.7 6.7 6.4 1.4 1 1 0 1 1 1 0 MIF4G like TBCA PF02970.11 KII67690.1 - 2.2 8.4 7.5 1.1 9.3 1.3 2.4 1 1 1 2 2 2 0 Tubulin binding cofactor A FliJ PF02050.11 KII67690.1 - 2.9 7.9 11.1 0.43 10.6 1.8 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein V-SNARE PF05008.10 KII67690.1 - 3.5 7.8 8.1 3.8 7.7 1.6 2.7 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF2116 PF09889.4 KII67690.1 - 3.5 7.4 5.3 0.54 10.1 0.5 1.9 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MSC PF09402.5 KII67690.1 - 5 5.7 7.6 8.4 5.0 5.2 1.3 1 1 0 1 1 1 0 Man1-Src1p-C-terminal domain FF PF01846.14 KII67691.1 - 5.9e-27 93.3 18.8 5.1e-08 32.7 0.0 6.6 8 0 0 8 8 8 4 FF domain FLYWCH PF04500.11 KII67692.1 - 4.1e-13 48.9 4.5 7.8e-13 48.1 2.4 1.9 2 0 0 2 2 2 1 FLYWCH zinc finger domain Usp PF00582.21 KII67696.1 - 7.3e-11 42.4 0.0 2.1e-10 40.9 0.0 1.7 1 1 0 1 1 1 1 Universal stress protein family Vps26 PF03643.10 KII67697.1 - 2.5e-38 131.4 1.8 3.2e-38 131.0 1.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 HEPPP_synt_1 PF07307.6 KII67698.1 - 0.012 15.0 0.0 0.025 14.0 0.0 1.6 1 1 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 MAPKK1_Int PF08923.5 KII67698.1 - 0.025 14.1 0.1 0.06 12.9 0.1 1.6 1 0 0 1 1 1 0 Mitogen-activated protein kinase kinase 1 interacting Oxidored_q1 PF00361.15 KII67698.1 - 0.096 11.9 2.1 0.1 11.8 0.8 1.4 2 0 0 2 2 2 0 NADH-Ubiquinone/plastoquinone (complex I), various chains Dimer_Tnp_hAT PF05699.9 KII67700.1 - 2.9e-08 33.2 0.0 5.8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Col_cuticle_N PF01484.12 KII67701.1 - 1.9 8.2 5.9 1.7 8.4 0.1 2.4 1 1 1 2 2 2 0 Nematode cuticle collagen N-terminal domain SPC25 PF06703.6 KII67701.1 - 5.7 6.4 6.8 20 4.7 2.4 2.0 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Ras PF00071.17 KII67702.1 - 5.2e-59 198.2 0.1 6.2e-59 198.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII67702.1 - 4.2e-20 72.4 0.1 8.9e-20 71.3 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KII67702.1 - 3.8e-15 55.5 0.0 4.5e-15 55.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KII67702.1 - 4.8e-07 29.1 0.0 6e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KII67702.1 - 0.00017 21.0 0.0 0.00026 20.5 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KII67702.1 - 0.00017 21.5 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase CPT PF07931.7 KII67702.1 - 0.009 15.6 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein DUF258 PF03193.11 KII67702.1 - 0.088 11.9 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF4334 PF14232.1 KII67702.1 - 0.099 12.2 0.0 2.2 7.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4334) G-alpha PF00503.15 KII67702.1 - 0.11 11.1 0.0 1 7.9 0.0 2.1 1 1 1 2 2 2 0 G-protein alpha subunit RVP PF00077.15 KII67703.1 - 2.4e-07 30.6 0.0 3.8e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII67703.1 - 0.0061 17.0 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease rve PF00665.21 KII67704.1 - 1.2e-18 67.3 0.1 2e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII67704.1 - 0.015 14.7 0.0 0.043 13.3 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain NYD-SP28_assoc PF14775.1 KII67704.1 - 0.06 13.0 0.1 15 5.3 0.0 2.7 2 0 0 2 2 2 0 Sperm tail C-terminal domain zf-H2C2 PF09337.5 KII67704.1 - 0.061 12.7 0.4 0.061 12.7 0.3 2.0 3 0 0 3 3 3 0 His(2)-Cys(2) zinc finger Peptidase_C1 PF00112.18 KII67705.1 - 2.2e-27 96.3 0.3 3.9e-27 95.5 0.2 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII67705.1 - 1.6e-12 47.4 5.4 2.6e-12 46.8 3.7 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) HTH_29 PF13551.1 KII67706.1 - 8.4e-10 38.7 0.4 2.8e-08 33.8 0.0 2.2 1 1 1 2 2 2 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII67706.1 - 1e-06 28.7 0.5 1.1e-05 25.4 0.0 2.5 2 1 1 3 3 3 1 Transposase HTH_32 PF13565.1 KII67706.1 - 4.6e-06 27.3 0.1 9.4e-05 23.1 0.0 2.2 1 1 1 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII67706.1 - 9.5e-06 25.5 0.0 0.00021 21.2 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 KII67706.1 - 1.3e-05 24.6 0.2 0.00012 21.5 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII67706.1 - 6.5e-05 22.5 0.1 0.00011 21.8 0.1 1.5 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.1 KII67706.1 - 0.00028 20.3 0.0 0.00069 19.1 0.0 1.7 1 1 0 1 1 1 1 Winged helix-turn helix HTH_24 PF13412.1 KII67706.1 - 0.00079 18.7 0.3 0.59 9.5 0.0 3.0 2 1 0 2 2 2 2 Winged helix-turn-helix DNA-binding Phage_RpbA PF10789.4 KII67706.1 - 0.0092 15.8 0.2 0.016 15.0 0.1 1.4 1 0 0 1 1 1 1 Phage RNA polymerase binding, RpbA HTH_Tnp_1 PF01527.15 KII67706.1 - 0.028 14.3 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 Transposase Phenyl_P_gamma PF09662.5 KII67706.1 - 0.055 13.1 0.5 5.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) NUMOD1 PF07453.8 KII67706.1 - 0.12 12.2 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 NUMOD1 domain PAX PF00292.13 KII67706.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 'Paired box' domain HTH_17 PF12728.2 KII67706.1 - 0.18 12.0 2.2 3.5 7.9 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_32 PF13565.1 KII67707.1 - 0.0044 17.7 0.0 0.0078 16.9 0.0 1.4 1 1 0 1 1 1 1 Homeodomain-like domain TIP41 PF04176.8 KII67708.1 - 1.1e-07 31.2 0.0 1.1e-07 31.2 0.0 1.0 1 0 0 1 1 1 1 TIP41-like family MFS_Mycoplasma PF07672.8 KII67712.1 - 0.0056 15.8 0.4 0.012 14.8 0.3 1.5 1 0 0 1 1 1 1 Mycoplasma MFS transporter Rifin_STEVOR PF02009.11 KII67713.1 - 8.5e-05 22.3 5.3 8.5e-05 22.3 3.7 5.5 1 1 2 3 3 3 1 Rifin/stevor family Baculo_11_kDa PF06143.6 KII67713.1 - 0.011 15.1 1.6 0.062 12.6 1.1 2.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family RCR PF12273.3 KII67713.1 - 0.015 15.8 0.0 0.015 15.8 0.0 5.1 3 2 0 4 4 4 0 Chitin synthesis regulation, resistance to Congo red P12 PF12669.2 KII67713.1 - 0.78 9.9 2.3 1.3 9.2 1.6 1.3 1 0 0 1 1 1 0 Virus attachment protein p12 family DDE_Tnp_1_7 PF13843.1 KII67715.1 - 2.8e-08 33.2 0.1 3.1e-08 33.0 0.0 1.0 1 0 0 1 1 1 1 Transposase IS4 MFS_Mycoplasma PF07672.8 KII67716.1 - 0.056 12.6 0.1 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 Mycoplasma MFS transporter CTP_synth_N PF06418.9 KII67717.1 - 7.1e-97 323.7 5.7 4.9e-96 321.0 2.0 2.0 1 1 1 2 2 2 2 CTP synthase N-terminus GATase PF00117.23 KII67717.1 - 7.1e-46 156.0 0.0 1.1e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 KII67717.1 - 5.9e-06 25.8 0.0 2.8e-05 23.6 0.0 2.1 2 1 0 2 2 2 1 Peptidase C26 CbiA PF01656.18 KII67717.1 - 0.094 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Galactosyl_T PF01762.16 KII67718.1 - 2.5e-20 72.8 0.4 4.4e-20 72.1 0.2 1.3 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.16 KII67719.1 - 1.1e-25 90.4 3.9 1.5e-25 89.9 2.7 1.2 1 0 0 1 1 1 1 Galactosyltransferase SH2 PF00017.19 KII67720.1 - 0.019 14.7 0.6 0.035 13.9 0.4 1.4 1 0 0 1 1 1 0 SH2 domain RRM_1 PF00076.17 KII67724.1 - 3.2e-24 84.3 0.5 1.7e-11 43.5 0.0 3.0 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII67724.1 - 1.4e-19 69.6 0.1 6.9e-10 38.6 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII67724.1 - 6.9e-13 48.3 0.1 3.6e-06 26.8 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.1 KII67724.1 - 0.025 14.1 0.0 0.054 13.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Tropomyosin PF00261.15 KII67725.1 - 6.5e-10 38.5 43.8 5.5e-06 25.6 21.5 2.4 1 1 1 2 2 2 2 Tropomyosin YlqD PF11068.3 KII67725.1 - 0.00037 20.5 6.9 0.00037 20.5 4.8 3.7 1 1 3 4 4 4 1 YlqD protein CENP-F_leu_zip PF10473.4 KII67725.1 - 0.00045 20.0 40.5 0.022 14.5 8.3 3.1 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NPV_P10 PF05531.7 KII67725.1 - 0.00047 20.3 22.4 0.015 15.5 2.7 4.3 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein DUF2968 PF11180.3 KII67725.1 - 0.00057 19.3 28.1 0.02 14.2 6.8 2.8 1 1 1 3 3 3 2 Protein of unknown function (DUF2968) Myosin_tail_1 PF01576.14 KII67725.1 - 0.00081 17.2 45.5 0.022 12.4 19.5 2.0 1 1 1 2 2 2 2 Myosin tail FlaC_arch PF05377.6 KII67725.1 - 0.0015 18.4 20.3 1.3 8.9 0.9 5.0 3 2 1 4 4 4 2 Flagella accessory protein C (FlaC) Spc7 PF08317.6 KII67725.1 - 0.0015 17.2 38.7 0.0042 15.8 7.1 3.1 1 1 2 3 3 3 1 Spc7 kinetochore protein Cast PF10174.4 KII67725.1 - 0.0022 16.1 39.5 0.067 11.2 6.1 2.1 1 1 1 2 2 2 2 RIM-binding protein of the cytomatrix active zone HrpB7 PF09486.5 KII67725.1 - 0.0085 16.0 1.3 0.0085 16.0 0.9 3.6 1 1 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) Reo_sigmaC PF04582.7 KII67725.1 - 0.011 14.8 15.0 0.31 10.1 3.0 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein GAS PF13851.1 KII67725.1 - 0.015 14.5 41.8 0.066 12.3 8.4 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding V_ATPase_I PF01496.14 KII67725.1 - 0.02 12.7 26.6 0.023 12.5 18.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.9 KII67725.1 - 0.022 14.3 42.8 0.07 12.7 8.9 3.4 1 1 3 4 4 4 0 IncA protein ATG16 PF08614.6 KII67725.1 - 0.022 14.5 40.2 0.29 10.9 17.5 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) APG6 PF04111.7 KII67725.1 - 0.023 13.7 43.4 0.09 11.8 9.9 2.5 1 1 0 2 2 2 0 Autophagy protein Apg6 MscS_porin PF12795.2 KII67725.1 - 0.053 12.8 35.9 0.46 9.7 8.3 2.5 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Laminin_II PF06009.7 KII67725.1 - 0.059 13.1 28.6 0.42 10.3 4.6 3.8 2 1 2 4 4 4 0 Laminin Domain II WXG100 PF06013.7 KII67725.1 - 0.075 13.0 18.5 0.36 10.8 1.8 3.8 2 2 2 4 4 4 0 Proteins of 100 residues with WXG DUF2580 PF10824.3 KII67725.1 - 0.083 13.2 5.9 0.064 13.6 0.9 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2580) Laminin_I PF06008.9 KII67725.1 - 0.12 11.6 34.2 0.52 9.5 5.9 2.3 1 1 0 2 2 2 0 Laminin Domain I ERM PF00769.14 KII67725.1 - 0.14 11.6 42.1 1.4 8.3 7.1 2.6 1 1 0 2 2 2 0 Ezrin/radixin/moesin family LOH1CR12 PF10158.4 KII67725.1 - 0.22 11.3 13.6 1.8 8.3 2.1 3.2 2 1 1 3 3 3 0 Tumour suppressor protein DUF4200 PF13863.1 KII67725.1 - 0.23 11.4 44.0 0.19 11.6 10.5 3.8 1 1 1 3 3 3 0 Domain of unknown function (DUF4200) Flagellar_rod PF05149.7 KII67725.1 - 0.32 10.1 34.1 0.017 14.3 14.6 2.9 1 1 2 3 3 3 0 Paraflagellar rod protein Atg14 PF10186.4 KII67725.1 - 0.35 9.7 34.6 0.68 8.8 12.9 2.0 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_13 PF13166.1 KII67725.1 - 0.43 8.9 36.0 0.19 10.1 5.4 2.5 1 1 1 2 2 2 0 AAA domain TMF_DNA_bd PF12329.3 KII67725.1 - 0.53 10.1 42.8 0.33 10.7 2.8 4.4 2 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding HAP1_N PF04849.8 KII67725.1 - 0.58 9.0 33.8 0.63 8.9 13.3 3.3 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Osmo_CC PF08946.5 KII67725.1 - 0.61 10.1 13.3 2 8.5 1.0 3.9 3 0 0 3 3 3 0 Osmosensory transporter coiled coil DUF869 PF05911.6 KII67725.1 - 0.66 8.1 36.8 1.6 6.8 25.5 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF869) EzrA PF06160.7 KII67725.1 - 0.75 7.9 32.7 0.59 8.2 9.2 2.2 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA BLOC1_2 PF10046.4 KII67725.1 - 0.87 9.7 28.2 0.15 12.2 3.5 3.7 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lebercilin PF15619.1 KII67725.1 - 1 8.7 42.1 4 6.8 10.0 3.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Filament PF00038.16 KII67725.1 - 1.1 8.6 38.1 6.4 6.1 26.4 2.1 1 1 0 1 1 1 0 Intermediate filament protein CorA PF01544.13 KII67725.1 - 1.2 8.1 19.5 0.081 11.9 4.3 2.7 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF812 PF05667.6 KII67725.1 - 1.2 7.5 35.1 0.14 10.6 8.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF812) WEMBL PF05701.6 KII67725.1 - 1.2 7.4 39.8 3.1 6.1 27.6 1.7 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DUF641 PF04859.7 KII67725.1 - 1.3 8.7 29.9 1.2 8.9 5.0 3.4 1 1 1 3 3 3 0 Plant protein of unknown function (DUF641) DUF4201 PF13870.1 KII67725.1 - 1.5 8.2 36.9 2.8 7.3 7.0 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) Occludin_ELL PF07303.8 KII67725.1 - 1.7 9.3 28.1 2.2 9.0 1.5 4.2 1 1 3 4 4 4 0 Occludin homology domain TMF_TATA_bd PF12325.3 KII67725.1 - 1.8 8.3 34.2 1.1 8.9 5.6 3.5 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding IFT57 PF10498.4 KII67725.1 - 2 7.0 33.5 1.7 7.3 11.5 2.6 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 AAA_27 PF13514.1 KII67725.1 - 2.3 5.7 34.9 8.2 3.9 24.2 1.7 1 1 0 1 1 1 0 AAA domain DUF3584 PF12128.3 KII67725.1 - 2.9 5.0 40.7 4.7 4.4 18.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Cortex-I_coil PF09304.5 KII67725.1 - 4 7.5 40.8 0.96 9.5 4.1 3.8 1 1 4 5 5 5 0 Cortexillin I, coiled coil Nup54 PF13874.1 KII67725.1 - 7.4 6.2 29.1 1.1 8.9 6.8 3.4 2 2 1 3 3 3 0 Nucleoporin complex subunit 54 Fib_alpha PF08702.5 KII67725.1 - 7.5 6.6 28.4 9.9 6.2 4.4 3.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Mod_r PF07200.8 KII67725.1 - 8.3 6.3 34.1 1.6 8.6 9.6 3.4 1 1 3 4 4 4 0 Modifier of rudimentary (Mod(r)) protein DUF1664 PF07889.7 KII67725.1 - 9.7 6.0 24.8 1.2 8.9 3.3 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) SNARE PF05739.14 KII67725.1 - 9.8 5.9 19.4 1.3 8.7 1.3 4.4 3 1 1 5 5 4 0 SNARE domain DUF4164 PF13747.1 KII67725.1 - 9.9 6.3 37.2 1.7 8.8 3.1 4.9 1 1 5 6 6 6 0 Domain of unknown function (DUF4164) FDX-ACB PF03147.9 KII67726.1 - 2.3e-22 78.9 0.0 2.8e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2d PF01409.15 KII67726.1 - 8.3e-05 21.9 0.0 0.00013 21.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2d PF01409.15 KII67727.1 - 2.6e-35 121.8 0.2 1.5e-34 119.2 0.1 1.9 1 1 1 2 2 2 2 tRNA synthetases class II core domain (F) Vinculin PF01044.14 KII67728.1 - 1.4e-37 129.3 35.7 5.6e-19 67.7 3.2 2.7 2 1 0 2 2 2 2 Vinculin family Herpes_UL3 PF03369.8 KII67728.1 - 0.013 15.4 2.0 0.049 13.5 1.4 2.0 1 0 0 1 1 1 0 Herpesvirus UL3 protein Sec23_helical PF04815.10 KII67728.1 - 0.083 12.3 3.6 8 5.9 0.0 4.0 2 1 1 3 3 3 0 Sec23/Sec24 helical domain Noggin PF05806.7 KII67729.1 - 1.6e-08 34.1 7.4 5.9e-08 32.2 5.1 1.8 1 1 0 1 1 1 1 Noggin Kdo PF06293.9 KII67730.1 - 0.12 11.3 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_33 PF13592.1 KII67731.1 - 0.067 12.7 0.0 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn helix CAMSAP_CKK PF08683.6 KII67732.1 - 8.7e-22 77.1 0.1 1.2e-21 76.6 0.1 1.1 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated DUF787 PF05619.6 KII67732.1 - 0.0019 16.9 0.2 0.0039 15.9 0.1 1.5 1 1 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF787) PrcB_C PF14343.1 KII67732.1 - 0.14 11.9 0.1 0.48 10.1 0.0 1.9 3 0 0 3 3 3 0 PrcB C-terminal Glyco_hydro_85 PF03644.8 KII67734.1 - 2.7e-43 148.2 1.2 3.1e-43 148.0 0.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 HSP70 PF00012.15 KII67735.1 - 0.041 11.8 2.3 0.055 11.3 1.6 1.1 1 0 0 1 1 1 0 Hsp70 protein Dimer_Tnp_hAT PF05699.9 KII67736.1 - 0.033 13.8 0.3 0.23 11.1 0.0 2.3 2 1 0 2 2 2 0 hAT family C-terminal dimerisation region Noggin PF05806.7 KII67737.1 - 1.3e-08 34.4 9.2 1.3e-08 34.4 6.4 1.7 2 0 0 2 2 2 1 Noggin DUF4137 PF13593.1 KII67738.1 - 1.2e-38 132.9 30.4 1.8e-37 129.1 21.0 1.9 1 1 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.11 KII67738.1 - 3.1e-10 39.7 21.4 8.1e-10 38.4 10.9 3.2 1 1 1 2 2 2 1 Sodium Bile acid symporter family DUF4027 PF13219.1 KII67738.1 - 0.0077 15.6 1.2 0.044 13.2 0.4 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4027) HTH_3 PF01381.17 KII67740.1 - 4e-09 36.1 0.2 6e-09 35.6 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.2 KII67740.1 - 1.7e-06 27.9 0.2 2.3e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 KII67740.1 - 0.00068 19.7 0.0 0.00093 19.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain MitMem_reg PF13012.1 KII67740.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function CDC45 PF02724.9 KII67742.1 - 8.1e-78 262.0 5.9 9.5e-48 162.6 0.2 3.0 1 1 2 3 3 3 3 CDC45-like protein BNR PF02012.15 KII67745.1 - 0.0047 16.5 12.9 1.3 9.1 0.0 4.5 4 0 0 4 4 4 3 BNR/Asp-box repeat DUF3827 PF12877.2 KII67746.1 - 0.14 10.2 0.4 0.16 10.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) OppC_N PF12911.2 KII67746.1 - 9 5.7 7.6 0.21 11.0 0.6 1.8 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Hema_HEFG PF02710.9 KII67747.1 - 0.069 13.4 0.1 0.096 12.9 0.1 1.2 1 0 0 1 1 1 0 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein TMEM51 PF15345.1 KII67747.1 - 0.1 12.2 0.1 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Phage_connect_1 PF05135.8 KII67748.1 - 0.2 11.8 1.9 0.27 11.4 1.3 1.3 1 1 0 1 1 1 0 Phage gp6-like head-tail connector protein Kunitz_BPTI PF00014.18 KII67749.1 - 0.011 15.9 4.3 0.011 15.9 3.0 2.5 2 2 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain rve PF00665.21 KII67751.1 - 0.069 13.2 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain MULE PF10551.4 KII67752.1 - 1.2e-09 38.1 0.0 2.9e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Utp13 PF08625.6 KII67754.1 - 0.002 17.7 0.0 0.37 10.4 0.0 2.7 3 0 0 3 3 3 2 Utp13 specific WD40 associated domain Abhydrolase_5 PF12695.2 KII67756.1 - 2.3e-21 76.1 0.0 2.9e-21 75.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KII67756.1 - 2.2e-10 40.8 0.0 4.3e-06 26.7 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII67756.1 - 4.4e-07 29.6 0.2 0.0084 15.6 0.1 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold DUF818 PF05677.7 KII67756.1 - 1.4e-06 27.3 0.3 2.4e-06 26.5 0.2 1.5 1 1 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) DUF1057 PF06342.7 KII67756.1 - 1.5e-05 23.9 0.0 2.6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_2 PF02230.11 KII67756.1 - 0.00072 19.0 0.2 0.0088 15.5 0.1 2.4 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 KII67756.1 - 0.00081 19.1 0.1 0.0063 16.3 0.0 2.3 3 0 0 3 3 3 1 Putative lysophospholipase Peptidase_S9 PF00326.16 KII67756.1 - 0.0043 16.3 0.1 0.023 13.9 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.8 KII67756.1 - 0.023 14.1 0.0 0.033 13.6 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.13 KII67756.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 1 0 1 1 1 0 Dienelactone hydrolase family DUF1577 PF07614.6 KII67757.1 - 0.011 14.5 0.2 0.018 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) FCH PF00611.18 KII67760.1 - 0.0083 16.2 0.2 0.0094 16.1 0.2 1.2 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DUF4484 PF14831.1 KII67760.1 - 0.024 14.7 0.6 0.024 14.7 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) TEX12 PF15219.1 KII67760.1 - 0.027 14.4 0.3 0.034 14.1 0.2 1.2 1 0 0 1 1 1 0 Testis-expressed 12 Snf7 PF03357.16 KII67761.1 - 0.027 13.8 7.6 0.047 13.0 5.3 1.5 1 1 0 1 1 1 0 Snf7 ESCRT-II PF05871.7 KII67762.1 - 0.011 15.6 0.0 0.055 13.3 0.0 1.9 2 0 0 2 2 2 0 ESCRT-II complex subunit Prok_Ub PF14454.1 KII67762.1 - 0.045 13.4 0.0 0.095 12.3 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin DUF4320 PF14208.1 KII67764.1 - 0.045 13.7 0.1 0.14 12.1 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4320) Phage_CI_repr PF07022.8 KII67766.1 - 0.033 14.2 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain PduL PF06130.7 KII67768.1 - 0.068 12.9 0.1 0.28 11.0 0.0 2.0 2 0 0 2 2 2 0 Propanediol utilisation protein PduL rve PF00665.21 KII67769.1 - 1.7e-09 37.8 0.0 2.7e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII67771.1 - 7.6e-06 25.7 0.0 1.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII67771.1 - 0.091 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease PduL PF06130.7 KII67773.1 - 0.03 14.1 0.1 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 Propanediol utilisation protein PduL DUF2762 PF10960.3 KII67774.1 - 0.085 12.5 0.1 22 4.8 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2762) RVT_1 PF00078.22 KII67775.1 - 3.7e-11 42.7 1.2 7.2e-11 41.8 0.1 2.0 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.22 KII67776.1 - 2.4e-11 43.4 1.3 5.1e-11 42.3 0.1 2.0 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2762 PF10960.3 KII67777.1 - 0.085 12.5 0.1 22 4.8 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2762) TBD PF12845.2 KII67779.1 - 0.1 12.1 0.4 0.27 10.8 0.1 1.8 2 0 0 2 2 2 0 TBD domain Peptidase_S9 PF00326.16 KII67780.1 - 2.6e-09 36.5 0.0 3.1e-09 36.3 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.13 KII67780.1 - 0.0033 16.7 0.0 0.0042 16.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.8 KII67780.1 - 0.01 15.2 0.0 0.012 15.0 0.0 1.1 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 KII67780.1 - 0.016 14.9 0.0 0.018 14.8 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 KII67780.1 - 0.053 12.9 0.0 0.065 12.6 0.0 1.1 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase RNase_PH PF01138.16 KII67782.1 - 7.2e-11 42.5 0.1 1.1e-10 41.8 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 FAM194 PF14977.1 KII67782.1 - 0.085 11.8 0.1 0.18 10.7 0.1 1.5 1 1 0 1 1 1 0 FAM194 protein VCBS PF13517.1 KII67783.1 - 0.0095 16.2 0.6 0.0095 16.2 0.4 2.6 3 1 0 3 3 3 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII67783.1 - 0.084 12.5 0.2 4.5 7.0 0.0 3.2 3 0 0 3 3 3 0 FG-GAP repeat Carboxyl_trans PF01039.17 KII67787.1 - 7.7e-110 367.5 0.0 1.1e-109 367.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.7 KII67787.1 - 9.5e-105 351.2 1.4 9.5e-105 351.2 1.0 2.0 2 0 0 2 2 2 1 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.12 KII67787.1 - 3e-49 167.1 0.0 6e-49 166.1 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 KII67787.1 - 7.7e-19 67.6 0.0 2.3e-18 66.1 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 KII67787.1 - 3.6e-11 42.5 0.1 1.2e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme CPSase_L_chain PF00289.17 KII67787.1 - 9.6e-11 41.7 0.0 2.1e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 KII67787.1 - 2.2e-09 37.3 0.0 5e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 KII67787.1 - 3.1e-05 23.3 0.0 7.5e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KII67787.1 - 0.0002 20.2 0.0 0.0018 17.0 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 KII67787.1 - 0.00022 20.6 0.0 0.00047 19.5 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus WTF PF03303.8 KII67788.1 - 1.7 7.9 8.3 1.3 8.3 4.9 1.3 1 1 0 1 1 1 0 WTF protein Nipped-B_C PF12830.2 KII67789.1 - 3.5e-26 91.9 2.8 3.5e-26 91.9 1.9 4.7 5 0 0 5 5 5 1 Sister chromatid cohesion C-terminus HEAT PF02985.17 KII67789.1 - 0.00079 19.2 0.1 6.4 7.1 0.0 5.0 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.1 KII67789.1 - 0.002 18.3 0.0 0.027 14.7 0.0 2.6 2 0 0 2 2 2 1 HEAT repeats Cohesin_HEAT PF12765.2 KII67789.1 - 0.34 10.9 2.2 1.5 8.8 0.1 3.0 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion DUF489 PF04356.7 KII67789.1 - 0.41 10.1 5.8 9.5 5.7 0.2 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF489) DDE_3 PF13358.1 KII67790.1 - 0.012 15.3 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_3 PF13358.1 KII67791.1 - 0.001 18.8 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3523 PF12037.3 KII67792.1 - 5.9e-34 117.2 9.5 9.2e-34 116.6 6.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.24 KII67792.1 - 1.4e-22 80.3 0.0 3.3e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KII67792.1 - 1.3e-06 28.6 0.0 0.0017 18.5 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII67792.1 - 7.4e-05 23.5 0.0 7.4e-05 23.5 0.0 2.8 2 2 0 2 2 2 1 AAA domain AAA_5 PF07728.9 KII67792.1 - 0.00034 20.3 0.1 0.0025 17.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KII67792.1 - 0.00066 19.7 0.1 0.007 16.3 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 KII67792.1 - 0.00086 18.4 0.0 0.0018 17.3 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KII67792.1 - 0.00099 18.9 0.0 0.0033 17.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KII67792.1 - 0.0017 17.8 0.2 1.3 8.3 0.0 2.6 2 0 0 2 2 2 2 AAA-like domain AAA_25 PF13481.1 KII67792.1 - 0.0026 17.1 0.0 0.0056 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KII67792.1 - 0.0027 16.9 0.3 0.04 13.0 0.0 2.7 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 KII67792.1 - 0.0036 16.7 0.0 0.011 15.2 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.1 KII67792.1 - 0.0078 15.8 0.0 0.096 12.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KII67792.1 - 0.0081 16.3 0.7 0.075 13.2 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_14 PF13173.1 KII67792.1 - 0.014 15.3 1.6 0.028 14.3 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA_28 PF13521.1 KII67792.1 - 0.019 14.9 3.0 0.16 11.9 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.1 KII67792.1 - 0.022 15.0 4.1 0.043 14.1 0.0 3.2 3 1 0 3 3 3 0 AAA domain Cytochrom_B562 PF07361.6 KII67793.1 - 0.036 14.4 2.8 0.13 12.7 0.1 2.8 3 1 0 3 3 3 0 Cytochrome b562 VSP PF03302.8 KII67794.1 - 6.6e-05 21.7 0.9 7.6e-05 21.5 0.6 1.0 1 0 0 1 1 1 1 Giardia variant-specific surface protein zf-CCHC PF00098.18 KII67794.1 - 0.00092 19.0 4.8 0.0051 16.6 1.7 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.1 KII67794.1 - 0.052 13.0 4.0 0.56 9.7 0.8 2.3 2 0 0 2 2 2 0 Zinc knuckle DUF1312 PF07009.6 KII67794.1 - 0.079 12.7 1.4 0.12 12.2 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1312) SNAP PF14938.1 KII67795.1 - 1.5e-11 43.9 0.8 1.7e-11 43.8 0.6 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII67795.1 - 0.0079 16.1 0.5 0.018 15.0 0.2 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII67795.1 - 0.069 12.7 2.5 0.099 12.3 0.6 2.0 2 0 0 2 2 2 0 TPR repeat NSF PF02071.15 KII67795.1 - 0.2 12.3 3.5 33 5.7 0.1 4.0 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat MIT PF04212.13 KII67795.1 - 0.25 11.2 2.4 2.6 8.0 0.5 3.1 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 KII67795.1 - 0.74 9.8 3.4 2.5 8.2 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII67795.1 - 3.7 7.3 0.0 3.7 7.3 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.21 KII67796.1 - 2.1e-32 112.1 0.4 9.3e-32 110.0 0.1 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 PS_pyruv_trans PF04230.8 KII67796.1 - 4.5e-28 98.7 0.2 1.2e-27 97.4 0.1 1.7 1 0 0 1 1 1 1 Polysaccharide pyruvyl transferase Glyco_tranf_2_2 PF10111.4 KII67796.1 - 4.1e-13 49.0 0.5 7.4e-13 48.2 0.3 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.1 KII67796.1 - 4.4e-12 46.3 0.0 7.3e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 KII67796.1 - 0.0044 17.3 0.0 0.013 15.7 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 Peptidase_S24 PF00717.18 KII67796.1 - 0.028 14.0 0.6 0.45 10.1 0.1 2.4 2 0 0 2 2 2 0 Peptidase S24-like UDPG_MGDP_dh_N PF03721.9 KII67797.1 - 1.8e-42 144.8 0.2 2.5e-42 144.3 0.1 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.14 KII67797.1 - 8.7e-26 89.9 0.0 1.8e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.10 KII67797.1 - 7.1e-10 38.9 0.9 3.1e-07 30.5 0.0 2.4 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_Gly3P_dh_N PF01210.18 KII67797.1 - 2.1e-05 24.3 0.1 5.7e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.13 KII67797.1 - 0.00023 20.8 0.1 0.00062 19.4 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ldh_1_N PF00056.18 KII67797.1 - 0.0055 16.5 0.4 0.012 15.4 0.3 1.6 1 1 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain F420_oxidored PF03807.12 KII67797.1 - 0.013 15.9 0.0 1.9 8.9 0.0 3.5 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent Glyco_hydro_4 PF02056.11 KII67797.1 - 0.015 14.6 0.5 0.081 12.2 0.1 2.2 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase ApbA PF02558.11 KII67797.1 - 0.022 14.2 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Methyltransf_16 PF10294.4 KII67797.1 - 0.098 12.1 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Peripla_BP_4 PF13407.1 KII67797.1 - 0.098 11.9 0.0 0.25 10.6 0.0 1.7 1 0 0 1 1 1 0 Periplasmic binding protein domain 6PGD PF00393.14 KII67798.1 - 1.5e-122 408.3 2.0 7.5e-122 406.1 1.4 2.0 1 1 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 KII67798.1 - 2.7e-53 180.1 0.0 2.2e-52 177.1 0.0 2.3 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.11 KII67798.1 - 3.1e-05 23.4 0.0 6.3e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.12 KII67798.1 - 0.00073 19.9 0.1 0.0025 18.2 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 KII67798.1 - 0.0042 17.1 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 KII67798.1 - 0.0065 16.1 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 KII67798.1 - 0.0089 15.7 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.14 KII67798.1 - 0.036 13.2 0.0 0.063 12.4 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 KII67798.1 - 0.059 12.7 0.2 0.43 9.9 0.0 2.4 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_11 PF14833.1 KII67798.1 - 0.092 12.8 0.2 0.28 11.2 0.1 1.8 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Beta_helix PF13229.1 KII67799.1 - 0.0013 18.4 30.3 0.0013 18.4 21.0 2.5 1 1 1 2 2 2 1 Right handed beta helix region Glycos_transf_1 PF00534.15 KII67800.1 - 4.9e-12 45.5 0.0 1.4e-11 44.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 RmlD_sub_bind PF04321.12 KII67801.1 - 1e-32 113.1 0.0 1.1e-32 113.0 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain dTDP_sugar_isom PF00908.12 KII67802.1 - 2.1e-73 245.4 0.0 2.3e-73 245.2 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase NTP_transferase PF00483.18 KII67803.1 - 4.2e-51 173.6 0.0 5e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Epimerase PF01370.16 KII67804.1 - 5.3e-75 251.8 0.0 6.6e-75 251.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 KII67804.1 - 1.4e-15 56.8 0.1 1.2e-13 50.6 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.12 KII67804.1 - 5.2e-15 55.0 0.0 8e-15 54.4 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 KII67804.1 - 5.5e-15 55.0 0.0 8e-15 54.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 KII67804.1 - 1.6e-12 46.7 0.0 3.1e-12 45.8 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 KII67804.1 - 1.9e-05 24.6 0.2 0.00017 21.5 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 KII67804.1 - 0.019 14.6 0.0 0.042 13.4 0.0 1.6 2 0 0 2 2 2 0 KR domain DapB_N PF01113.15 KII67804.1 - 0.022 14.6 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Saccharop_dh PF03435.13 KII67804.1 - 0.032 13.2 0.1 0.045 12.7 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Ldh_1_N PF00056.18 KII67804.1 - 0.057 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Glycos_transf_2 PF00535.21 KII67805.1 - 1.2e-15 57.6 0.0 1.9e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII67805.1 - 3e-12 46.8 0.0 3.8e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KII67805.1 - 1.6e-06 27.9 0.0 2.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 KII67805.1 - 1.8e-06 27.3 0.0 4.1e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 Bac_transf PF02397.11 KII67806.1 - 1.5e-67 226.3 0.0 2.1e-67 225.8 0.0 1.2 1 0 0 1 1 1 1 Bacterial sugar transferase CoA_binding_3 PF13727.1 KII67806.1 - 9.2e-07 28.8 0.0 2.8e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 CoA-binding domain Wzz PF02706.10 KII67807.1 - 4.6e-50 169.3 0.4 4.6e-50 169.3 0.3 2.4 2 0 0 2 2 2 1 Chain length determinant protein LMWPc PF01451.16 KII67807.1 - 1.2e-38 132.5 0.0 2.4e-38 131.5 0.0 1.6 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase GNVR PF13807.1 KII67807.1 - 4.8e-33 112.7 0.6 1.3e-32 111.3 0.4 1.8 1 0 0 1 1 1 1 G-rich domain on putative tyrosine kinase Poly_export PF02563.11 KII67807.1 - 2.1e-29 101.1 0.1 5.6e-29 99.7 0.1 1.8 1 0 0 1 1 1 1 Polysaccharide biosynthesis/export protein AAA_31 PF13614.1 KII67807.1 - 1.1e-18 67.6 0.1 5e-18 65.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain SLBB PF10531.4 KII67807.1 - 3.4e-12 46.0 1.9 4.9e-07 29.5 0.0 3.4 3 0 0 3 3 3 2 SLBB domain CbiA PF01656.18 KII67807.1 - 4.2e-10 39.3 0.0 9.2e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.1 KII67807.1 - 8.7e-05 22.2 1.1 0.19 11.3 0.1 3.1 3 0 0 3 3 3 2 AAA domain ArsA_ATPase PF02374.10 KII67807.1 - 0.00055 19.0 3.2 0.65 8.9 0.1 3.9 4 0 0 4 4 4 2 Anion-transporting ATPase AAA_25 PF13481.1 KII67807.1 - 0.056 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SM PF04612.7 KII67807.1 - 0.2 11.4 6.1 0.11 12.2 0.4 2.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Caps_assemb_Wzi PF14052.1 KII67808.1 - 7.9e-20 71.1 2.0 5.9e-14 51.7 0.1 2.0 1 1 1 2 2 2 2 Capsule assembly protein Wzi PAP2 PF01569.16 KII67809.1 - 7.9e-10 38.5 16.1 9.5e-10 38.2 6.9 2.3 1 1 1 2 2 2 2 PAP2 superfamily NTP_transferase PF00483.18 KII67810.1 - 4.1e-20 72.1 0.0 5e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 KII67810.1 - 2.7e-05 24.2 0.1 5.3e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 MobA-like NTP transferase domain CorC_HlyC PF03471.12 KII67812.1 - 1.3e-21 76.0 0.2 4.9e-20 71.0 0.0 2.5 1 1 1 2 2 2 1 Transporter associated domain CBS PF00571.23 KII67812.1 - 8.4e-16 57.4 0.6 1.2e-09 37.8 0.0 2.7 3 0 0 3 3 3 2 CBS domain AsmA_2 PF13502.1 KII67813.1 - 4.6e-08 32.6 0.0 6.1e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 AsmA-like C-terminal region AsmA PF05170.9 KII67813.1 - 0.0001 21.0 0.4 0.0001 21.0 0.2 1.5 2 0 0 2 2 2 1 AsmA family GCM PF03615.10 KII67813.1 - 0.057 13.0 0.1 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 GCM motif protein PUB PF09409.5 KII67814.1 - 6.9e-10 38.5 0.0 1.6e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 PUB domain Dimer_Tnp_hAT PF05699.9 KII67817.1 - 4e-05 23.1 0.1 7.1e-05 22.3 0.1 1.4 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region PH_7 PF15408.1 KII67818.1 - 0.023 14.5 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain FbpA PF05833.6 KII67818.1 - 0.053 12.0 1.0 0.079 11.4 0.7 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Ank PF00023.25 KII67819.1 - 6e-27 92.0 1.1 7.3e-09 35.0 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 KII67819.1 - 1e-23 83.4 0.2 8.4e-16 58.1 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KII67819.1 - 1.6e-19 69.8 2.2 6.5e-12 45.6 0.2 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII67819.1 - 4.8e-19 66.5 1.0 4.5e-06 26.3 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KII67819.1 - 6.7e-18 64.3 0.6 3.9e-09 36.4 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) TPR_12 PF13424.1 KII67819.1 - 2.1e-15 56.4 12.2 6.4e-05 22.8 0.2 5.4 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 KII67819.1 - 3.5e-05 23.3 14.7 0.02 14.5 1.1 4.2 4 1 0 4 4 4 2 TPR repeat TPR_8 PF13181.1 KII67819.1 - 0.045 13.5 0.5 0.045 13.5 0.3 7.2 7 1 1 8 8 8 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 KII67819.1 - 0.052 12.8 0.9 0.5 9.6 0.0 3.0 3 0 0 3 3 3 0 SHNi-TPR TPR_2 PF07719.12 KII67819.1 - 0.08 12.9 19.6 6.6 6.9 0.1 7.7 9 0 0 9 9 9 0 Tetratricopeptide repeat PPO1_DWL PF12142.3 KII67822.1 - 0.14 11.6 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Polyphenol oxidase middle domain Metallophos PF00149.23 KII67825.1 - 0.00044 19.6 1.1 0.00054 19.4 0.7 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Rnf-Nqr PF02508.9 KII67827.1 - 0.015 14.8 2.3 0.018 14.6 1.6 1.1 1 0 0 1 1 1 0 Rnf-Nqr subunit, membrane protein DUF2244 PF10003.4 KII67827.1 - 1 8.7 7.7 0.87 8.9 1.5 2.1 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Ldl_recept_a PF00057.13 KII67830.1 - 1.1e-18 66.8 30.2 4.1e-11 42.5 9.2 2.1 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII67833.1 - 1.1e-36 124.4 122.9 1.8e-10 40.5 8.1 8.3 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A ATG11 PF10377.4 KII67834.1 - 0.058 13.2 0.3 0.082 12.8 0.2 1.2 1 0 0 1 1 1 0 Autophagy-related protein 11 BNR PF02012.15 KII67835.1 - 0.00036 19.9 4.8 1.4 9.0 0.5 3.5 3 0 0 3 3 3 3 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII67836.1 - 4.1e-12 45.7 30.4 1.4e-09 37.7 8.0 4.4 5 0 0 5 5 5 2 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII67836.1 - 0.0051 16.4 11.1 0.83 9.7 0.1 4.6 4 0 0 4 4 4 3 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII67837.1 - 4.3e-17 61.7 28.6 3e-11 43.0 7.9 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII67838.1 - 0.0016 17.9 3.5 0.8 9.7 0.5 3.1 2 0 0 2 2 2 2 BNR/Asp-box repeat Kelch_4 PF13418.1 KII67838.1 - 0.24 11.1 0.8 1.4 8.7 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain DUF1900 PF08954.6 KII67839.1 - 0.03 13.8 0.3 0.13 11.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1900) Methyltransf_23 PF13489.1 KII67839.1 - 0.11 12.2 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TAF1_subA PF14929.1 KII67840.1 - 0.024 13.0 0.2 0.032 12.7 0.1 1.1 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A Mo-co_dimer PF03404.11 KII67840.1 - 0.053 13.1 0.0 11 5.7 0.0 2.8 3 0 0 3 3 3 0 Mo-co oxidoreductase dimerisation domain BNR PF02012.15 KII67840.1 - 0.35 10.8 6.0 22 5.4 0.3 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat YgbB PF02542.11 KII67842.1 - 0.057 13.2 0.0 0.086 12.6 0.0 1.2 1 0 0 1 1 1 0 YgbB family FAA_hydrolase PF01557.13 KII67843.1 - 4.3e-32 111.3 0.0 5.7e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF1779 PF08680.5 KII67847.1 - 0.056 13.3 0.6 0.081 12.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1779) HAMP PF00672.20 KII67848.1 - 0.001 19.2 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 HAMP domain YmzC PF14157.1 KII67848.1 - 0.022 14.5 2.0 0.059 13.2 0.1 2.6 3 0 0 3 3 3 0 YmzC-like protein MFS_1 PF07690.11 KII67849.1 - 3.5e-17 62.1 46.5 3.5e-17 62.1 32.2 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.2 KII67849.1 - 0.015 15.0 1.9 0.015 15.0 1.3 3.0 3 0 0 3 3 3 0 MFS_1 like family Molybdopterin PF00384.17 KII67850.1 - 1.3e-80 271.3 0.1 1.4e-80 271.1 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.16 KII67850.1 - 1.6e-21 76.2 0.0 3.6e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Nitr_red_alph_N PF14710.1 KII67850.1 - 9.8e-15 54.5 3.6 2.3e-14 53.3 2.5 1.7 1 0 0 1 1 1 1 Respiratory nitrate reductase alpha N-terminal Molybdop_Fe4S4 PF04879.11 KII67850.1 - 0.0021 17.8 0.3 0.01 15.6 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin oxidoreductase Fe4S4 domain Fer4_11 PF13247.1 KII67851.1 - 4.8e-30 103.3 8.0 4.8e-30 103.3 5.5 1.7 2 0 0 2 2 1 1 4Fe-4S dicluster domain Nitr_red_bet_C PF14711.1 KII67851.1 - 1.8e-28 97.8 0.0 3.2e-28 97.0 0.0 1.4 1 0 0 1 1 1 1 Respiratory nitrate reductase beta C-terminal Nitrate_red_del PF02613.10 KII67851.1 - 6.7e-21 74.5 0.6 1.8e-20 73.1 0.1 1.9 2 0 0 2 2 2 1 Nitrate reductase delta subunit Fer4_7 PF12838.2 KII67851.1 - 2.1e-08 34.4 10.5 0.00011 22.4 0.2 3.4 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.1 KII67851.1 - 2.2e-06 27.3 18.4 0.022 14.5 0.2 3.6 3 0 0 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.2 KII67851.1 - 0.00015 21.5 20.6 0.011 15.6 0.1 4.2 3 1 1 4 4 4 2 4Fe-4S binding domain Fer4_2 PF12797.2 KII67851.1 - 0.0005 19.8 19.1 0.0058 16.4 1.6 4.5 4 0 0 4 4 4 2 4Fe-4S binding domain Fer4_9 PF13187.1 KII67851.1 - 0.003 17.7 18.9 0.53 10.5 0.4 3.6 3 0 0 3 3 3 3 4Fe-4S dicluster domain Fer4 PF00037.22 KII67851.1 - 0.02 14.4 2.1 0.02 14.4 1.4 4.7 3 1 1 4 4 4 0 4Fe-4S binding domain Fer4_21 PF14697.1 KII67851.1 - 0.043 13.6 0.5 0.043 13.6 0.3 3.6 3 1 1 4 4 4 0 4Fe-4S dicluster domain Fer4_13 PF13370.1 KII67851.1 - 0.061 13.7 0.1 0.061 13.7 0.1 3.1 3 0 0 3 3 2 0 4Fe-4S single cluster domain iPGM_N PF06415.8 KII67851.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 BPG-independent PGAM N-terminus (iPGM_N) Fer4_15 PF13459.1 KII67851.1 - 0.21 12.1 0.1 0.21 12.1 0.1 4.0 4 0 0 4 4 3 0 4Fe-4S single cluster domain Fer4_17 PF13534.1 KII67851.1 - 1.3 9.4 13.5 0.74 10.2 0.1 3.9 3 1 0 3 3 3 0 4Fe-4S dicluster domain Fer4_4 PF12800.2 KII67851.1 - 2.1 8.8 23.9 1.7 9.1 1.5 4.1 4 0 0 4 4 3 0 4Fe-4S binding domain Fer4_8 PF13183.1 KII67851.1 - 3 7.9 16.2 0.67 10.0 3.8 3.7 2 2 0 2 2 2 0 4Fe-4S dicluster domain Nitrate_red_gam PF02665.9 KII67852.1 - 1.1e-39 136.0 9.8 1.1e-39 136.0 6.2 1.4 1 1 0 1 1 1 1 Nitrate reductase gamma subunit MarR_2 PF12802.2 KII67853.1 - 7.5e-15 54.3 0.1 1.4e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR PF01047.17 KII67853.1 - 3.2e-08 33.1 0.2 2.6e-07 30.2 0.0 2.3 3 0 0 3 3 3 1 MarR family HTH_27 PF13463.1 KII67853.1 - 2.3e-07 31.0 0.1 4.2e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_34 PF13601.1 KII67853.1 - 0.018 15.0 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain FeoC PF09012.5 KII67853.1 - 0.023 14.4 0.1 1.8 8.3 0.0 2.3 2 0 0 2 2 2 0 FeoC like transcriptional regulator ANT PF03374.9 KII67853.1 - 0.027 14.5 0.5 0.33 11.0 0.2 2.7 1 1 0 1 1 1 0 Phage antirepressor protein KilAC domain DinB_2 PF12867.2 KII67853.1 - 0.048 14.0 0.8 0.42 10.9 0.2 2.3 1 1 1 2 2 2 0 DinB superfamily PadR PF03551.9 KII67853.1 - 0.061 13.0 0.2 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_45 PF14947.1 KII67853.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix HxlR PF01638.12 KII67853.1 - 0.12 11.9 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Flavin_Reduct PF01613.13 KII67854.1 - 4.5e-11 42.8 0.0 5.6e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Corona_NS4 PF03905.8 KII67854.1 - 0.007 16.1 1.3 0.014 15.1 0.9 1.4 1 0 0 1 1 1 1 Coronavirus non-structural protein NS4 DUF447 PF04289.7 KII67854.1 - 0.12 11.8 0.5 1.2 8.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF447) DGC PF08859.6 KII67855.1 - 8.3e-26 90.0 0.2 1e-25 89.6 0.1 1.1 1 0 0 1 1 1 1 DGC domain DDE_Tnp_IS1595 PF12762.2 KII67856.1 - 1.1e-18 67.4 0.0 1.3e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain AlkA_N PF06029.6 KII67857.1 - 0.0091 16.0 0.5 0.022 14.8 0.3 1.6 1 1 0 1 1 1 1 AlkA N-terminal domain DUF892 PF05974.7 KII67857.1 - 0.052 13.3 1.5 0.059 13.1 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF892) Hairpins PF04877.7 KII67857.1 - 0.058 12.8 0.1 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 HrpZ SATase_N PF06426.9 KII67857.1 - 0.15 12.2 1.4 0.31 11.3 0.3 1.8 1 1 0 2 2 2 0 Serine acetyltransferase, N-terminal Rpn3_C PF08375.6 KII67857.1 - 0.25 11.7 2.1 0.39 11.1 0.2 2.1 2 0 0 2 2 2 0 Proteasome regulatory subunit C-terminal PhoU PF01895.14 KII67857.1 - 0.4 11.1 3.2 1 9.8 0.5 2.1 1 1 0 2 2 2 0 PhoU domain SIR2 PF02146.12 KII67861.1 - 0.13 12.0 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Sir2 family P4Ha_N PF08336.6 KII67862.1 - 4.8e-11 42.6 0.9 1.8e-10 40.7 0.0 2.4 3 0 0 3 3 3 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_12 PF13424.1 KII67862.1 - 0.02 14.8 0.2 0.044 13.7 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII67862.1 - 0.034 13.7 0.0 0.077 12.6 0.0 1.6 1 0 0 1 1 1 0 TPR repeat DUF4230 PF14014.1 KII67862.1 - 0.041 13.7 0.2 0.077 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) BLOC1_2 PF10046.4 KII67863.1 - 0.0018 18.3 0.3 0.0031 17.6 0.2 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 PALP PF00291.20 KII67864.1 - 1.2e-16 60.8 0.0 1.6e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme UPF0258 PF06789.7 KII67865.1 - 0.039 14.0 0.4 0.053 13.5 0.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) DUF3827 PF12877.2 KII67865.1 - 0.1 10.6 6.1 0.14 10.2 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) LRR19-TM PF15176.1 KII67865.1 - 0.11 12.2 1.9 0.18 11.5 1.3 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain B12D PF06522.6 KII67865.1 - 0.11 12.1 0.5 0.21 11.2 0.4 1.4 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF4191 PF13829.1 KII67865.1 - 0.11 11.5 0.2 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) PNPOx_C PF10590.4 KII67867.1 - 0.32 10.5 2.2 1.6 8.2 0.3 2.6 2 1 1 3 3 3 0 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region CDC14 PF08045.6 KII67868.1 - 0.0054 15.9 0.1 0.0065 15.6 0.0 1.1 1 0 0 1 1 1 1 Cell division control protein 14, SIN component KAP PF05804.7 KII67868.1 - 0.01 13.7 0.1 0.012 13.6 0.0 1.0 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) GIIM PF08388.6 KII67868.1 - 0.017 14.8 0.2 0.025 14.3 0.2 1.4 1 1 0 1 1 1 0 Group II intron, maturase-specific domain Kelch_6 PF13964.1 KII67869.1 - 3.2e-11 42.9 2.3 0.022 14.9 0.0 4.8 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.1 KII67869.1 - 2.8e-10 39.7 4.5 0.00037 20.1 0.2 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII67869.1 - 1.2e-05 24.7 1.6 0.29 10.6 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 KII67869.1 - 3.9e-05 23.6 5.2 1.8 8.8 0.1 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII67869.1 - 0.00025 20.6 0.1 0.92 9.3 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.1 KII67869.1 - 0.0039 17.0 0.3 0.064 13.2 0.1 2.7 2 0 0 2 2 2 1 Kelch motif PBP_sp32 PF07222.7 KII67870.1 - 0.086 12.0 0.5 0.15 11.2 0.4 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 rve PF00665.21 KII67871.1 - 6.6e-24 84.3 0.0 3.7e-23 81.8 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII67871.1 - 4.5e-16 58.8 0.0 9.6e-16 57.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII67871.1 - 4.9e-08 32.7 0.1 9.7e-08 31.8 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII67871.1 - 8.5e-05 22.3 0.0 0.0002 21.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII67871.1 - 0.00013 22.3 0.0 0.0003 21.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease rve_3 PF13683.1 KII67871.1 - 0.0027 17.1 0.0 0.0087 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain PIRT PF15099.1 KII67871.1 - 0.13 11.5 0.2 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family zf-CCHC PF00098.18 KII67871.1 - 3.6 7.7 10.5 0.31 11.0 2.4 2.6 2 0 0 2 2 2 0 Zinc knuckle Galactosyl_T PF01762.16 KII67873.1 - 1.7e-09 37.5 0.1 2.2e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase 6PF2K PF01591.13 KII67874.1 - 1.2e-60 204.3 4.5 1.8e-60 203.7 3.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 KII67874.1 - 7.4e-14 52.1 0.0 1.3e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 KII67874.1 - 3.8e-08 33.3 0.0 5.9e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII67874.1 - 4.6e-06 27.4 0.0 1.1e-05 26.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 KII67874.1 - 0.0012 18.1 0.0 0.0024 17.1 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 KII67874.1 - 0.0083 15.2 0.0 0.025 13.7 0.0 1.6 1 1 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 KII67874.1 - 0.015 15.4 0.0 0.042 13.9 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.9 KII67874.1 - 0.13 12.0 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CENP-B_dimeris PF09026.5 KII67876.1 - 0.025 14.8 2.0 0.032 14.4 1.4 1.4 1 1 0 1 1 1 0 Centromere protein B dimerisation domain MSG PF02349.10 KII67876.1 - 0.15 12.0 3.3 0.52 10.3 0.1 2.1 2 0 0 2 2 2 0 Major surface glycoprotein FERM_N PF09379.5 KII67877.1 - 1.7e-06 27.9 0.1 2.6e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 FERM N-terminal domain TUG-UBL1 PF11470.3 KII67877.1 - 0.038 13.9 0.4 0.092 12.6 0.2 1.6 2 0 0 2 2 2 0 GLUT4 regulating protein TUG IPPT PF01715.12 KII67879.1 - 7.2e-48 162.8 0.1 1e-47 162.2 0.0 1.2 1 0 0 1 1 1 1 IPP transferase zf-C2H2_jaz PF12171.3 KII67879.1 - 1.3e-07 31.4 3.0 1.3e-07 31.4 2.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KII67879.1 - 8.2e-06 25.8 4.1 2.9e-05 24.1 2.8 2.0 1 0 0 1 1 1 1 Zinc-finger of C2H2 type IPT PF01745.11 KII67879.1 - 2.3e-05 23.7 0.0 0.00091 18.4 0.0 2.3 2 0 0 2 2 2 1 Isopentenyl transferase AAA_18 PF13238.1 KII67879.1 - 0.00073 19.8 1.5 0.1 12.8 1.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII67879.1 - 0.0011 19.7 0.5 0.0029 18.4 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KII67879.1 - 0.0043 16.9 0.1 0.069 13.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 KII67879.1 - 0.016 14.6 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF3505 PF12013.3 KII67879.1 - 0.022 14.9 0.2 0.058 13.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) AAA PF00004.24 KII67879.1 - 0.071 13.3 0.0 0.21 11.8 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.18 KII67879.1 - 0.071 12.4 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.1 KII67879.1 - 0.12 11.7 0.4 0.32 10.3 0.1 1.9 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.1 KII67879.1 - 0.12 12.1 1.4 0.3 10.8 0.1 2.3 3 0 0 3 3 3 0 Part of AAA domain DUF3599 PF12206.3 KII67881.1 - 0.15 12.3 0.8 0.48 10.7 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3599) HD PF01966.17 KII67882.1 - 1.5e-08 34.6 0.0 3.5e-08 33.4 0.0 1.8 1 1 0 1 1 1 1 HD domain DDE_Tnp_IS1595 PF12762.2 KII67883.1 - 4.9e-23 81.6 0.0 8e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain MRP-S31 PF15433.1 KII67884.1 - 2.2e-08 33.8 0.0 3.2e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 Nop14 PF04147.7 KII67885.1 - 0.00012 20.2 2.2 0.00012 20.2 1.5 1.9 2 0 0 2 2 2 2 Nop14-like family Nop14 PF04147.7 KII67887.1 - 6.6e-16 57.4 7.9 7.9e-16 57.1 5.5 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2247 PF10004.4 KII67887.1 - 0.00091 18.9 1.5 0.0013 18.4 0.9 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2247) Aida_N PF08910.5 KII67887.1 - 0.1 12.8 4.5 1.1 9.4 1.7 2.2 1 1 1 2 2 2 0 Aida N-terminus Ribosomal_S13 PF00416.17 KII67887.1 - 3.4 8.1 7.6 3.2 8.2 0.3 2.2 1 1 1 2 2 2 0 Ribosomal protein S13/S18 DDE_Tnp_IS1595 PF12762.2 KII67888.1 - 1e-05 25.3 0.0 4.8e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 ISXO2-like transposase domain 7tm_1 PF00001.16 KII67889.1 - 4e-06 26.1 4.7 5.1e-06 25.8 3.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Syja_N PF02383.13 KII67890.1 - 3.7e-57 193.5 0.6 6.6e-57 192.6 0.4 1.4 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 KII67890.1 - 2.1e-26 93.3 0.5 6.3e-26 91.8 0.1 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family FLYWCH PF04500.11 KII67891.1 - 4.6 7.2 7.3 0.14 12.0 0.9 1.7 2 0 0 2 2 2 0 FLYWCH zinc finger domain DDE_3 PF13358.1 KII67892.1 - 4.9e-28 97.7 0.0 6.5e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Acetyltransf_1 PF00583.19 KII67894.1 - 8.8e-15 54.5 0.2 1.3e-14 53.9 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KII67894.1 - 4.7e-09 36.2 0.3 4.2e-08 33.2 0.1 2.2 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KII67894.1 - 3.8e-06 26.5 0.1 5.7e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 KII67894.1 - 7.7e-06 26.0 0.0 1.3e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KII67894.1 - 2.1e-05 24.5 1.2 7.4e-05 22.7 0.3 2.2 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KII67894.1 - 0.00022 21.4 0.0 0.0003 20.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KII67894.1 - 0.0034 17.2 0.1 0.0055 16.5 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 KII67894.1 - 0.024 14.5 0.0 0.054 13.3 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase CLU_N PF15044.1 KII67894.1 - 0.1 12.7 0.2 0.92 9.7 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial function, CLU-N-term DDE_Tnp_IS1595 PF12762.2 KII67896.1 - 7.8e-16 58.2 0.1 8.5e-16 58.1 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain HEAT_2 PF13646.1 KII67897.1 - 1.4e-08 34.8 0.1 0.058 13.6 0.0 4.0 4 0 0 4 4 4 3 HEAT repeats HEAT PF02985.17 KII67897.1 - 1.5e-08 34.0 1.2 0.013 15.5 0.0 5.8 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.1 KII67897.1 - 1.2e-06 28.7 0.4 0.2 12.2 0.1 4.5 5 0 0 5 5 5 2 HEAT-like repeat IBN_N PF03810.14 KII67897.1 - 6.6e-06 25.9 2.9 0.00012 21.8 0.0 4.1 5 1 1 6 6 6 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.2 KII67897.1 - 0.036 14.4 3.7 3.2 8.1 0.0 4.8 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region PBP_dimer PF03717.10 KII67897.1 - 0.064 13.3 0.1 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Penicillin-binding Protein dimerisation domain DDE_Tnp_IS1595 PF12762.2 KII67898.1 - 2.1e-05 24.3 0.0 4.1e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain Mitofilin PF09731.4 KII67899.1 - 0.33 9.5 13.9 0.36 9.4 9.6 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF4114 PF13448.1 KII67899.1 - 3.3 8.5 5.1 7.2 7.5 3.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4114) Pkinase PF00069.20 KII67900.1 - 1.8e-58 197.7 0.0 8.7e-58 195.5 0.0 2.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII67900.1 - 3.8e-29 101.5 0.0 3.8e-29 101.5 0.0 2.6 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.1 KII67900.1 - 8e-10 38.1 0.0 2.6e-09 36.4 0.0 1.9 1 0 0 1 1 1 1 Kinase-like C1_1 PF00130.17 KII67900.1 - 0.00021 20.9 8.8 0.00055 19.6 6.1 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Rho_Binding PF08912.6 KII67900.1 - 0.00026 21.2 5.3 0.00026 21.2 3.7 8.3 3 1 5 9 9 9 1 Rho Binding APH PF01636.18 KII67900.1 - 0.0087 15.8 0.1 0.027 14.1 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_C PF00433.19 KII67900.1 - 0.031 14.7 0.5 0.1 13.1 0.4 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain DDE_3 PF13358.1 KII67907.1 - 4.3e-08 33.0 0.3 1.1e-07 31.7 0.2 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease PDZ PF00595.19 KII67908.1 - 1.8e-09 37.6 0.9 4.7e-09 36.3 0.6 1.7 1 1 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII67908.1 - 0.0014 18.4 0.2 0.0025 17.6 0.1 1.4 1 0 0 1 1 1 1 PDZ domain RICTOR_phospho PF14665.1 KII67909.1 - 0.027 14.5 0.0 0.058 13.4 0.0 1.6 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, phosphorylation-site Baculo_VP1054 PF05789.6 KII67909.1 - 0.028 13.5 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Baculovirus VP1054 protein Exonuc_VII_S PF02609.11 KII67909.1 - 0.14 11.9 0.2 4.6 7.0 0.0 2.2 1 1 1 2 2 2 0 Exonuclease VII small subunit LIM PF00412.17 KII67910.1 - 3.1e-30 104.0 39.7 2e-11 43.7 4.1 3.1 3 0 0 3 3 3 3 LIM domain zf-RING_6 PF14835.1 KII67910.1 - 0.0021 17.7 1.6 0.0021 17.7 1.1 3.3 2 2 2 4 4 4 1 zf-RING of BARD1-type protein LIM PF00412.17 KII67911.1 - 2.9e-27 94.5 48.6 8.3e-11 41.8 8.2 3.2 3 0 0 3 3 3 3 LIM domain PDZ_2 PF13180.1 KII67911.1 - 0.00044 20.0 0.0 0.0014 18.5 0.0 1.7 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.19 KII67911.1 - 0.02 15.0 0.1 0.04 14.0 0.1 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) DDE_1 PF03184.14 KII67912.1 - 3.7e-09 36.0 0.1 7.6e-09 35.0 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease ELYS PF13934.1 KII67912.1 - 0.046 13.4 0.1 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Nuclear pore complex assembly LacI PF00356.16 KII67913.1 - 0.00049 19.6 0.0 0.00086 18.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family ATP_bind_1 PF03029.12 KII67914.1 - 9.2e-34 117.0 0.1 1.1e-33 116.8 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein RNA_pol PF00940.14 KII67915.1 - 3.1e-97 325.6 0.9 3.1e-97 325.6 0.6 1.6 2 0 0 2 2 2 1 DNA-dependent RNA polymerase Surp PF01805.15 KII67916.1 - 8.5e-20 70.1 1.5 1e-18 66.7 0.1 2.9 3 0 0 3 3 3 1 Surp module RRM_1 PF00076.17 KII67916.1 - 1.9e-08 33.7 0.0 1.2e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII67916.1 - 3.2e-08 33.4 0.0 9.2e-08 31.9 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CTK3 PF12243.3 KII67916.1 - 0.0017 18.0 0.4 0.0037 16.8 0.3 1.5 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTD_bind PF04818.8 KII67916.1 - 0.0031 17.6 0.8 0.014 15.6 0.5 2.2 1 0 0 1 1 1 1 RNA polymerase II-binding domain. IBP39 PF11422.3 KII67916.1 - 0.031 13.8 1.1 2.8 7.4 0.1 3.2 3 1 0 3 3 3 0 Initiator binding protein 39 kDa Elong-fact-P_C PF09285.6 KII67918.1 - 2.1e-27 94.2 1.2 4e-27 93.3 0.3 1.9 2 1 0 2 2 2 1 Elongation factor P, C-terminal EFP_N PF08207.7 KII67918.1 - 5e-24 83.9 0.1 1.9e-23 82.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain EFP PF01132.15 KII67918.1 - 2.4e-23 81.5 0.0 4.5e-23 80.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain Radical_SAM PF04055.16 KII67919.1 - 4.2e-08 33.5 0.0 1.3e-07 31.9 0.0 1.9 2 1 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.1 KII67919.1 - 9.6e-07 28.8 0.0 2.4e-06 27.5 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 KII67919.1 - 1.6e-06 28.2 0.0 5.1e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain Trans_reg_C PF00486.23 KII67920.1 - 3.2e-13 49.3 0.0 5.3e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Fimbrial PF00419.15 KII67921.1 - 6.7e-09 36.1 9.9 8.3e-09 35.8 6.8 1.1 1 0 0 1 1 1 1 Fimbrial protein PapD_N PF00345.15 KII67922.1 - 3.1e-37 127.0 0.2 5.2e-37 126.3 0.2 1.3 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain PapD_C PF02753.12 KII67922.1 - 1.7e-10 40.5 2.2 2.8e-10 39.8 0.2 2.3 2 1 0 2 2 2 1 Pili assembly chaperone PapD, C-terminal domain Usher PF00577.15 KII67923.1 - 1.1e-190 635.0 27.5 1.4e-190 634.7 19.1 1.1 1 0 0 1 1 1 1 Outer membrane usher protein PapC_N PF13954.1 KII67923.1 - 3.8e-39 133.5 0.1 6.6e-39 132.8 0.0 1.4 1 0 0 1 1 1 1 PapC N-terminal domain PapC_C PF13953.1 KII67923.1 - 8.6e-18 63.7 0.1 1.8e-17 62.7 0.1 1.6 1 0 0 1 1 1 1 PapC C-terminal domain TraT PF05818.7 KII67925.1 - 0.0015 18.0 5.1 0.0021 17.5 3.6 1.3 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein Gly-zipper_YMGG PF13441.1 KII67925.1 - 0.065 12.7 17.7 0.23 11.0 12.3 1.9 1 1 0 1 1 1 0 YMGG-like Gly-zipper Bacteriocin_IId PF09221.5 KII67925.1 - 0.32 10.9 0.1 0.32 10.9 0.1 2.5 2 1 0 2 2 2 0 Bacteriocin class IId cyclical uberolysin-like Gly-zipper_OmpA PF13436.1 KII67925.1 - 2.8 7.6 14.6 4.2 7.0 9.6 1.7 1 1 1 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Rick_17kDa_Anti PF05433.10 KII67925.1 - 4.2 7.1 24.9 2.2 8.0 9.7 2.5 1 1 1 2 2 2 0 Glycine zipper 2TM domain DUF1269 PF06897.7 KII67925.1 - 5.5 7.0 10.3 2.2 8.3 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) HlyD PF00529.15 KII67926.1 - 3.1e-19 69.4 5.0 4e-19 69.0 3.4 1.1 1 0 0 1 1 1 1 HlyD family secretion protein HlyD_3 PF13437.1 KII67926.1 - 2.2e-15 56.8 4.9 4.6e-12 46.2 0.0 2.8 3 0 0 3 3 3 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.1 KII67926.1 - 3.1e-14 52.3 1.7 1.9e-07 30.6 0.2 3.0 2 1 0 2 2 2 2 Biotin-lipoyl like Biotin_lipoyl PF00364.17 KII67926.1 - 5.1e-07 29.2 1.5 0.011 15.2 0.2 2.7 2 0 0 2 2 2 2 Biotin-requiring enzyme Seryl_tRNA_N PF02403.17 KII67926.1 - 0.0043 17.0 4.8 0.0043 17.0 3.3 2.3 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain RraB PF06877.6 KII67926.1 - 0.02 15.5 1.4 0.12 13.0 0.3 2.5 2 1 0 2 2 2 0 Regulator of ribonuclease activity B IceA2 PF05862.6 KII67926.1 - 0.023 14.4 0.2 0.087 12.5 0.2 2.0 1 0 0 1 1 1 0 Helicobacter pylori IceA2 protein DUF2153 PF09921.4 KII67926.1 - 0.026 14.1 1.4 0.064 12.8 0.4 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2153) DUF2118 PF09891.4 KII67926.1 - 0.029 14.0 0.2 12 5.5 0.1 2.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) TBCA PF02970.11 KII67926.1 - 0.13 12.3 5.3 0.067 13.2 1.6 2.1 1 1 1 2 2 2 0 Tubulin binding cofactor A Peptidase_M23 PF01551.17 KII67926.1 - 0.26 11.3 5.7 3.6 7.6 0.3 3.6 3 1 1 4 4 4 0 Peptidase family M23 GvpK PF05121.7 KII67926.1 - 0.35 10.7 1.7 1.5 8.7 0.1 2.6 2 1 0 2 2 2 0 Gas vesicle protein K IncA PF04156.9 KII67926.1 - 1.4 8.4 9.9 2.4 7.7 6.4 1.7 1 1 0 1 1 1 0 IncA protein DUF2935 PF11155.3 KII67926.1 - 3.4 7.7 10.8 3 7.9 3.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) ABC_tran PF00005.22 KII67927.1 - 9.1e-31 106.9 0.0 1.4e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KII67927.1 - 4.3e-18 65.7 1.3 6.7e-18 65.0 0.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.1 KII67927.1 - 4.9e-09 36.5 0.0 1.3e-05 25.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 KII67927.1 - 5.6e-06 25.7 0.1 0.00015 21.0 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA PF00004.24 KII67927.1 - 0.00029 21.0 0.3 0.0053 16.9 0.2 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 KII67927.1 - 0.00032 20.1 0.1 0.0007 19.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 KII67927.1 - 0.00043 20.4 0.2 0.024 14.7 0.1 2.4 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KII67927.1 - 0.0012 18.0 0.0 0.0022 17.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 KII67927.1 - 0.0016 18.4 0.0 0.0041 17.1 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 KII67927.1 - 0.0022 18.7 0.0 0.0052 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KII67927.1 - 0.0028 16.8 0.0 0.0065 15.6 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_23 PF13476.1 KII67927.1 - 0.0029 17.9 0.0 0.0047 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII67927.1 - 0.0061 16.8 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KII67927.1 - 0.0089 15.4 1.0 0.11 11.8 0.1 2.5 3 0 0 3 3 3 1 AAA-like domain AAA_25 PF13481.1 KII67927.1 - 0.018 14.4 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 KII67927.1 - 0.036 13.8 0.1 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 KII67927.1 - 0.044 13.4 0.5 0.12 11.9 0.1 1.9 2 0 0 2 2 2 0 NACHT domain MobB PF03205.9 KII67927.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.12 KII67927.1 - 0.097 12.0 0.1 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.1 KII67927.1 - 0.099 12.5 0.0 0.36 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KII67927.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 KII67927.1 - 0.11 12.3 0.0 0.46 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KII67927.1 - 0.12 11.9 0.0 0.28 10.8 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase DUF4156 PF13698.1 KII67929.1 - 1.3e-30 105.0 0.2 2.2e-30 104.4 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4156) Cpn60_TCP1 PF00118.19 KII67929.1 - 7e-07 28.2 0.0 8.8e-07 27.8 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family LPAM_1 PF08139.7 KII67929.1 - 0.13 12.5 1.3 0.29 11.4 0.9 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site MLTD_N PF06474.7 KII67929.1 - 2.4 8.4 4.9 0.85 9.8 0.8 2.1 2 0 0 2 2 2 0 MltD lipid attachment motif Cpn60_TCP1 PF00118.19 KII67930.1 - 3.1e-82 276.7 5.1 3.4e-82 276.5 3.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cyclin_N PF00134.18 KII67931.1 - 0.016 14.8 0.3 0.04 13.4 0.1 1.8 2 0 0 2 2 2 0 Cyclin, N-terminal domain NBP1 PF08537.5 KII67931.1 - 0.024 13.8 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Prok-RING_2 PF14445.1 KII67931.1 - 0.075 12.9 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 FMN_bind_2 PF04299.7 KII67932.1 - 0.11 12.0 0.0 0.78 9.2 0.0 1.9 2 0 0 2 2 2 0 Putative FMN-binding domain Herpes_U15 PF05613.6 KII67937.1 - 0.22 11.8 1.7 16 5.9 0.1 2.2 1 1 1 2 2 2 0 Human herpesvirus U15 protein NPCBM PF08305.6 KII67938.1 - 0.067 13.1 0.0 0.098 12.6 0.0 1.2 1 0 0 1 1 1 0 NPCBM/NEW2 domain PLDc_N PF13396.1 KII67940.1 - 0.017 14.7 1.9 0.031 13.9 1.3 1.3 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal MerT PF02411.10 KII67941.1 - 0.014 15.2 0.2 0.019 14.7 0.1 1.3 1 0 0 1 1 1 0 MerT mercuric transport protein SecD-TM1 PF13721.1 KII67941.1 - 0.034 14.3 0.0 0.034 14.3 0.0 2.4 2 1 1 3 3 3 0 SecD export protein N-terminal TM region DUF1837 PF08878.6 KII67942.1 - 0.039 13.5 0.0 0.042 13.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1837) Sod_Cu PF00080.15 KII67943.1 - 1.2e-30 106.5 0.1 1.6e-30 106.1 0.1 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Serpin PF00079.15 KII67944.1 - 2.6e-45 155.1 0.2 2.9e-45 154.9 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) IceA2 PF05862.6 KII67944.1 - 0.057 13.1 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Helicobacter pylori IceA2 protein HTH_32 PF13565.1 KII67947.1 - 0.00015 22.4 0.0 0.0062 17.3 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII67947.1 - 0.0043 17.1 0.0 0.0076 16.3 0.0 1.4 1 1 0 1 1 1 1 Winged helix-turn helix HTH_40 PF14493.1 KII67947.1 - 0.013 15.7 0.3 0.02 15.1 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.1 KII67947.1 - 0.016 14.8 0.0 0.092 12.4 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain HTH_17 PF12728.2 KII67947.1 - 0.046 13.9 0.0 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain DUF1323 PF07037.6 KII67947.1 - 0.055 13.6 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) Ground-like PF04155.13 KII67947.1 - 0.059 13.6 0.2 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Ground-like domain CENP-B_N PF04218.8 KII67947.1 - 0.066 12.6 0.2 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain TrmB PF01978.14 KII67947.1 - 0.11 12.2 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB UvdE PF03851.9 KII67948.1 - 0.045 12.7 0.0 0.065 12.2 0.0 1.2 1 0 0 1 1 1 0 UV-endonuclease UvdE WYL PF13280.1 KII67951.1 - 0.062 13.1 0.0 0.071 12.9 0.0 1.1 1 0 0 1 1 1 0 WYL domain Sod_Cu PF00080.15 KII67956.1 - 8.1e-28 97.3 0.1 1e-27 97.0 0.1 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Ctf8 PF09696.5 KII67956.1 - 0.055 13.2 0.0 0.069 12.9 0.0 1.1 1 0 0 1 1 1 0 Ctf8 Sod_Cu PF00080.15 KII67957.1 - 1.6e-36 125.5 0.6 2.1e-36 125.1 0.4 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Sod_Cu PF00080.15 KII67958.1 - 6.1e-37 126.9 0.1 7.4e-37 126.6 0.1 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) KOW PF00467.24 KII67961.1 - 0.0071 16.0 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 KOW motif HTH_28 PF13518.1 KII67962.1 - 3.9e-05 23.5 0.0 6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 KII67962.1 - 0.00012 21.6 0.0 0.0002 20.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII67962.1 - 0.00036 20.2 0.3 0.00051 19.7 0.2 1.4 1 1 0 1 1 1 1 Transposase PAX PF00292.13 KII67962.1 - 0.0063 16.2 0.0 0.0078 15.9 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain DUF3523 PF12037.3 KII67962.1 - 0.013 14.4 1.3 0.015 14.3 0.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3523) HTH_29 PF13551.1 KII67962.1 - 0.018 15.1 0.0 0.021 14.9 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn helix HTH_32 PF13565.1 KII67962.1 - 0.083 13.7 0.0 0.21 12.3 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain AT_hook PF02178.14 KII67963.1 - 3.2 7.7 8.9 7.1 6.6 6.1 1.5 1 0 0 1 1 1 0 AT hook motif GDPD PF03009.12 KII67964.1 - 1.9e-46 158.6 0.0 2.7e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DDE_Tnp_IS1595 PF12762.2 KII67965.1 - 2e-21 76.4 0.0 2.7e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Peptidase_C1 PF00112.18 KII67966.1 - 1.3e-66 224.6 0.3 1.8e-66 224.2 0.2 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII67966.1 - 8.6e-13 48.3 0.9 1.5e-12 47.6 0.6 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KII67966.1 - 2.3e-05 23.0 0.2 0.00022 19.8 0.1 2.0 2 0 0 2 2 2 1 Peptidase C1-like family PI3_PI4_kinase PF00454.22 KII67967.1 - 5.5e-29 101.3 0.0 7.7e-29 100.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase START PF01852.14 KII67969.1 - 2.2e-18 66.3 0.0 2.8e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 START domain DUF3074 PF11274.3 KII67969.1 - 0.0024 17.5 0.2 0.0063 16.1 0.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3074) Na_H_Exchanger PF00999.16 KII67970.1 - 1.4e-43 148.9 31.7 2.6e-43 148.0 22.0 1.4 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family DUF4604 PF15377.1 KII67971.1 - 0.066 13.4 6.9 0.083 13.1 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Pilus_CpaD PF09476.5 KII67971.1 - 0.16 11.4 0.2 0.21 11.0 0.1 1.1 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) E2 PF08199.6 KII67974.1 - 0.46 10.1 3.6 0.94 9.1 2.5 1.5 1 0 0 1 1 1 0 Bacteriophage E2-like protein DUF2753 PF10952.3 KII67975.1 - 0.022 14.7 0.2 0.17 11.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2753) Tho2 PF11262.3 KII67978.1 - 0.05 12.6 0.1 0.08 11.9 0.1 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF3759 PF12585.3 KII67979.1 - 0.013 15.4 0.0 6.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3759) Ribosomal_L21e PF01157.13 KII67979.1 - 0.043 13.6 0.0 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L21e NB PF04159.8 KII67982.1 - 0.024 14.3 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 NB glycoprotein Retrotrans_gag PF03732.12 KII67983.1 - 0.0022 18.0 0.0 0.0049 16.9 0.0 1.6 2 0 0 2 2 2 1 Retrotransposon gag protein Fmp27_WPPW PF10359.4 KII67983.1 - 0.012 14.0 0.1 0.012 14.0 0.1 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain rve PF00665.21 KII67984.1 - 2.8e-07 30.6 0.2 1.1e-06 28.7 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.5 KII67984.1 - 0.00048 19.4 0.0 0.00085 18.6 0.0 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RVT_1 PF00078.22 KII67985.1 - 4.7e-18 65.3 0.0 7.1e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII67986.1 - 3.9e-07 29.9 0.0 2.5e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII67986.1 - 7.5e-05 22.4 0.5 7.5e-05 22.4 0.4 2.5 2 0 0 2 2 2 1 Zinc knuckle Asp_protease_2 PF13650.1 KII67986.1 - 0.0064 16.9 0.0 0.035 14.6 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC_4 PF14392.1 KII67986.1 - 0.018 14.7 11.3 0.063 12.9 3.0 2.6 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.9 KII67986.1 - 0.025 14.5 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Baculo_19 PF04798.7 KII67986.1 - 0.041 13.2 0.0 0.1 11.9 0.0 1.6 1 0 0 1 1 1 0 Baculovirus 19 kDa protein conserved region RVP_2 PF08284.6 KII67986.1 - 0.085 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease AFG1_ATPase PF03969.11 KII67988.1 - 6.2e-27 94.3 0.0 9.8e-27 93.6 0.0 1.3 1 0 0 1 1 1 1 AFG1-like ATPase rve PF00665.21 KII67988.1 - 1.2e-19 70.6 0.0 3.6e-19 69.0 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII67988.1 - 1.5e-07 30.9 0.0 1.4e-06 27.7 0.0 2.3 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII67988.1 - 0.00043 19.7 0.1 0.0017 17.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain AAA_22 PF13401.1 KII67988.1 - 0.0019 18.3 0.0 0.0076 16.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII67988.1 - 0.0026 17.7 0.0 0.051 13.5 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain zf-H2C2 PF09337.5 KII67988.1 - 0.037 13.4 1.5 0.066 12.6 0.3 2.1 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger AAA PF00004.24 KII67988.1 - 0.08 13.1 0.0 0.32 11.1 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 KII67988.1 - 0.085 12.4 0.0 16 4.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.11 KII67989.1 - 2.7e-13 49.4 0.1 3e-13 49.3 0.1 1.0 1 0 0 1 1 1 1 AFG1-like ATPase Aldo_ket_red PF00248.16 KII67991.1 - 3.3e-42 144.2 0.0 3.9e-42 144.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Intron_maturas2 PF01348.16 KII67991.1 - 0.00098 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 Type II intron maturase MaoC_dehydratas PF01575.14 KII67994.1 - 0.099 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 MaoC like domain RRM_1 PF00076.17 KII67995.1 - 7.1e-22 76.8 0.1 1.1e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII67995.1 - 2.3e-12 46.7 0.0 3.5e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII67995.1 - 3.7e-10 39.4 0.0 5.3e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Na_K-ATPase PF00287.13 KII67997.1 - 2e-08 33.3 1.2 1.1e-05 24.3 0.1 2.3 1 1 1 2 2 2 2 Sodium / potassium ATPase beta chain Zip PF02535.17 KII67999.1 - 1.8e-50 171.7 13.1 6.4e-50 169.9 9.1 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter HTH_33 PF13592.1 KII68000.1 - 6.5e-05 22.3 0.0 0.00021 20.7 0.0 1.9 1 0 0 1 1 1 1 Winged helix-turn helix p25-alpha PF05517.7 KII68000.1 - 0.026 14.7 0.1 0.052 13.7 0.1 1.6 1 0 0 1 1 1 0 p25-alpha DHquinase_II PF01220.14 KII68000.1 - 0.085 12.1 0.4 0.16 11.2 0.3 1.4 1 0 0 1 1 1 0 Dehydroquinase class II S-antigen PF05756.6 KII68001.1 - 6.8 6.7 6.8 2.2 8.3 1.0 2.1 2 0 0 2 2 2 0 S-antigen protein HTH_33 PF13592.1 KII68003.1 - 5.1e-07 29.1 0.1 8.9e-07 28.3 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII68003.1 - 8.9e-05 22.4 0.0 0.00019 21.4 0.0 1.6 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.1 KII68003.1 - 0.00012 22.2 0.1 0.00015 21.8 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII68003.1 - 0.0002 22.0 0.0 0.00026 21.7 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_DeoR PF08220.7 KII68003.1 - 0.025 14.1 0.0 0.054 13.0 0.0 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain DDE_Tnp_IS1595 PF12762.2 KII68004.1 - 1.1e-07 31.7 0.2 1.1e-06 28.5 0.1 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain DJ-1_PfpI PF01965.19 KII68005.1 - 2.7e-06 26.9 0.0 6.6e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family EamA PF00892.15 KII68006.1 - 9.8 6.2 12.9 0.35 10.9 3.9 2.3 3 1 0 3 3 3 0 EamA-like transporter family EamA PF00892.15 KII68007.1 - 0.00025 21.0 8.9 0.00025 21.0 6.1 1.7 2 0 0 2 2 2 1 EamA-like transporter family Ca_hom_mod PF14798.1 KII68008.1 - 0.0002 20.4 4.7 0.053 12.4 1.8 2.3 1 1 1 2 2 2 2 Calcium homeostasis modulator AceK PF06315.6 KII68008.1 - 0.014 13.7 0.1 0.02 13.1 0.1 1.2 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) TPT PF03151.11 KII68008.1 - 0.3 10.7 6.8 0.053 13.1 0.5 2.1 2 0 0 2 2 2 0 Triose-phosphate Transporter family YdjO PF14169.1 KII68009.1 - 0.02 14.3 0.9 0.063 12.7 0.1 2.1 2 0 0 2 2 2 0 Cold-inducible protein YdjO Dict-STAT-coil PF09267.5 KII68009.1 - 0.063 13.5 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 Dictyostelium STAT, coiled coil PmrD PF11183.3 KII68009.1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Polymyxin resistance protein PmrD DUF1280 PF06918.9 KII68009.1 - 0.17 11.0 1.6 1.9 7.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1280) rve PF00665.21 KII68010.1 - 2.8e-18 66.1 0.0 7.2e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII68010.1 - 1.3e-17 63.9 0.0 3.4e-17 62.5 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII68010.1 - 9.5e-05 22.2 0.0 0.00032 20.5 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII68010.1 - 0.00015 21.2 0.1 0.00048 19.6 0.1 2.0 1 0 0 1 1 1 1 Integrase core domain gag-asp_proteas PF13975.1 KII68010.1 - 0.0003 20.5 0.0 0.00089 19.0 0.0 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII68010.1 - 0.0014 18.4 0.8 0.0014 18.4 0.6 2.4 3 0 0 3 3 3 1 Zinc knuckle UBN2 PF14223.1 KII68010.1 - 0.0053 16.5 2.5 1.3 8.7 0.1 3.7 2 1 1 3 3 3 1 gag-polypeptide of LTR copia-type Asp_protease_2 PF13650.1 KII68010.1 - 0.012 16.1 0.0 0.032 14.7 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease Retrotrans_gag PF03732.12 KII68010.1 - 0.029 14.4 0.4 0.6 10.2 0.0 3.1 3 0 0 3 3 3 0 Retrotransposon gag protein Myb_DNA-bind_2 PF08914.6 KII68010.1 - 0.078 12.7 0.3 5.1 6.9 0.1 2.7 3 0 0 3 3 3 0 Rap1 Myb domain HTH_Tnp_ISL3 PF13542.1 KII68011.1 - 1.1e-07 30.9 0.0 5.5e-06 25.4 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.1 KII68011.1 - 2e-06 27.2 1.5 2e-05 24.1 0.0 2.4 2 1 0 2 2 2 1 Homeodomain-like domain PAX PF00292.13 KII68011.1 - 5.5e-06 26.1 0.2 7.7e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.1 KII68011.1 - 5.8e-06 26.4 0.1 1e-05 25.6 0.1 1.4 1 1 0 1 1 1 1 Winged helix-turn helix HTH_17 PF12728.2 KII68011.1 - 0.00018 21.6 0.2 0.045 14.0 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.1 KII68011.1 - 0.00018 21.3 0.0 0.0044 16.9 0.0 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain MarR_2 PF12802.2 KII68011.1 - 0.00058 19.4 0.0 0.0013 18.3 0.0 1.6 2 0 0 2 2 2 1 MarR family HTH_38 PF13936.1 KII68011.1 - 0.00097 18.6 0.2 0.00097 18.6 0.1 2.2 3 0 0 3 3 3 1 Helix-turn-helix domain CENP-B_N PF04218.8 KII68011.1 - 0.0011 18.3 0.1 0.0025 17.2 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.1 KII68011.1 - 0.0018 17.6 0.1 0.013 14.9 0.0 2.3 2 1 1 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_33 PF13592.1 KII68011.1 - 0.0022 17.4 0.0 0.006 16.0 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn helix HTH_3 PF01381.17 KII68011.1 - 0.0043 16.8 0.1 0.021 14.6 0.0 2.1 2 1 0 2 2 2 1 Helix-turn-helix B5 PF03484.10 KII68011.1 - 0.03 14.1 0.1 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetase B5 domain HTH_19 PF12844.2 KII68011.1 - 0.032 14.2 0.0 0.56 10.3 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4 PF04545.11 KII68011.1 - 0.032 13.5 0.3 0.072 12.4 0.1 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 NUMOD1 PF07453.8 KII68011.1 - 0.041 13.7 0.0 0.089 12.6 0.0 1.6 1 0 0 1 1 1 0 NUMOD1 domain LacI PF00356.16 KII68011.1 - 0.045 13.3 0.3 7.4 6.2 0.0 2.9 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family DUF1323 PF07037.6 KII68011.1 - 0.048 13.8 0.2 0.33 11.1 0.0 2.0 1 1 1 2 2 2 0 Putative transcription regulator (DUF1323) HTH_Tnp_Tc3_2 PF01498.13 KII68011.1 - 0.076 13.0 0.3 4.6 7.3 0.0 2.4 2 1 0 2 2 2 0 Transposase TrmB PF01978.14 KII68011.1 - 0.11 12.1 0.1 0.33 10.6 0.0 1.8 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Retrotrans_gag PF03732.12 KII68012.1 - 0.0011 18.9 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein Toprim_N PF08275.6 KII68012.1 - 0.0087 16.0 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 DNA primase catalytic core, N-terminal domain RE_Bpu10I PF09549.5 KII68012.1 - 0.024 14.2 0.1 0.028 13.9 0.0 1.1 1 0 0 1 1 1 0 Bpu10I restriction endonuclease GrpE PF01025.14 KII68016.1 - 0.013 15.0 0.5 0.024 14.1 0.3 1.4 1 0 0 1 1 1 0 GrpE AKAP95 PF04988.7 KII68017.1 - 1.1e-05 25.3 4.3 0.0027 17.5 0.0 2.6 1 1 1 2 2 2 2 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.7 KII68017.1 - 1.2 8.7 4.9 1.1 8.9 0.1 2.7 2 0 0 2 2 2 0 U1 zinc finger zf-met PF12874.2 KII68017.1 - 5.7 7.2 11.1 26 5.2 3.8 3.2 2 1 0 2 2 2 0 Zinc-finger of C2H2 type HTH_29 PF13551.1 KII68018.1 - 9.2e-06 25.7 0.0 1.4e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII68018.1 - 0.0055 17.4 0.0 0.0091 16.7 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_23 PF13384.1 KII68018.1 - 0.011 15.3 0.0 0.028 14.0 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_28 PF13518.1 KII68018.1 - 0.05 13.6 0.0 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Bombinin PF05298.6 KII68018.1 - 0.09 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Bombinin CPSase_L_D2 PF02786.12 KII68019.1 - 3.3e-64 216.0 0.1 3.6e-64 215.9 0.0 1.0 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.1 KII68019.1 - 2.9e-08 33.6 0.0 4.3e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KII68019.1 - 7.9e-06 25.4 0.0 1.2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 KII68019.1 - 0.00019 20.2 0.1 0.00054 18.8 0.1 1.8 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.6 KII68019.1 - 0.00075 19.0 0.0 0.0011 18.4 0.0 1.4 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp PF02222.17 KII68019.1 - 0.0095 15.3 0.0 0.012 15.0 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp domain Toxin_59 PF15537.1 KII68019.1 - 0.05 13.6 0.0 0.078 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative toxin 59 PilX_N PF14341.1 KII68019.1 - 0.079 12.6 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 PilX N-terminal CPSase_L_chain PF00289.17 KII68020.1 - 1.2e-33 115.5 0.0 1.5e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 KII68020.1 - 0.00028 19.7 0.0 0.00032 19.5 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon UPF0104 PF03706.8 KII68021.1 - 0.24 10.6 5.1 0.13 11.4 0.7 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0104) Hist_deacetyl PF00850.14 KII68022.1 - 1.2e-80 271.0 0.0 1.9e-80 270.4 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain EzrA PF06160.7 KII68023.1 - 0.0026 16.0 3.3 0.0029 15.8 2.3 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF3287 PF11690.3 KII68023.1 - 0.043 13.8 0.3 0.043 13.8 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) CS PF04969.11 KII68024.1 - 4.8e-07 30.2 0.2 6.9e-07 29.7 0.2 1.2 1 0 0 1 1 1 1 CS domain Aa_trans PF01490.13 KII68025.1 - 2e-58 197.8 32.8 2.3e-58 197.6 22.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein V_ATPase_I PF01496.14 KII68026.1 - 0.03 12.2 0.0 0.03 12.1 0.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SHMT PF00464.14 KII68027.1 - 1.8e-176 586.4 0.0 2.1e-176 586.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Coat_F PF07875.7 KII68027.1 - 0.056 13.5 0.3 0.2 11.8 0.0 1.9 2 0 0 2 2 2 0 Coat F domain V_ATPase_I PF01496.14 KII68028.1 - 5.6e-145 484.1 3.2 7.6e-145 483.6 2.2 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family FlaC_arch PF05377.6 KII68028.1 - 0.62 9.9 3.4 2.7 7.9 0.1 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) MULE PF10551.4 KII68029.1 - 0.012 15.7 0.0 0.068 13.3 0.0 1.9 2 0 0 2 2 2 0 MULE transposase domain Arfaptin PF06456.8 KII68030.1 - 4.7e-37 127.5 13.2 6.6e-37 127.0 9.2 1.1 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.19 KII68030.1 - 4.7e-13 49.1 0.0 1e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII68030.1 - 8.1e-06 25.6 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DUF2251 PF10008.4 KII68030.1 - 0.14 12.2 0.5 5.2 7.2 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2251) BAR PF03114.13 KII68030.1 - 0.93 8.9 9.1 2.8 7.3 6.3 1.8 1 1 0 1 1 1 0 BAR domain AA_permease_2 PF13520.1 KII68031.1 - 2.6e-18 65.7 30.9 3.4e-18 65.4 21.4 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII68031.1 - 8.1e-10 37.6 27.0 1.2e-09 37.0 18.7 1.2 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 KII68032.1 - 6.3e-18 64.5 24.9 7.3e-18 64.3 17.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KII68032.1 - 9e-10 37.4 23.2 1e-09 37.2 16.1 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2207 PF09972.4 KII68032.1 - 6.8 5.1 20.4 1.5e+04 -6.1 14.1 2.1 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DPM3 PF08285.6 KII68032.1 - 7.4 6.4 8.8 0.54 10.1 2.2 1.9 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) MutS_V PF00488.16 KII68033.1 - 2.6e-78 262.6 0.1 8e-78 261.0 0.0 1.8 2 0 0 2 2 2 1 MutS domain V MutS_I PF01624.15 KII68033.1 - 1.8e-30 105.2 0.0 4.2e-30 104.0 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.13 KII68033.1 - 2.8e-26 92.5 0.3 6.1e-26 91.4 0.2 1.6 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 KII68033.1 - 2.5e-16 59.6 0.6 2.5e-16 59.6 0.4 2.4 2 0 0 2 2 2 1 MutS family domain IV AAA_29 PF13555.1 KII68033.1 - 0.11 11.9 0.1 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain COesterase PF00135.23 KII68035.1 - 0.058 12.0 1.5 2.7 6.6 0.1 2.0 1 1 1 2 2 2 0 Carboxylesterase family Mito_carr PF00153.22 KII68038.1 - 1.3e-24 85.6 1.3 5.6e-08 32.3 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Rad21_Rec8_N PF04825.8 KII68039.1 - 1.5e-25 89.3 0.0 2.5e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 KII68039.1 - 4.3e-06 26.4 0.0 1.8e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 ScpA/B protein Rad21_Rec8 PF04824.11 KII68039.1 - 0.0014 17.7 0.0 0.0028 16.8 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein DUF3496 PF12001.3 KII68040.1 - 0.047 13.9 0.5 0.13 12.5 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3496) Feld-I_B PF09252.5 KII68040.1 - 0.086 12.7 0.1 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 Allergen Fel d I-B chain DUF4441 PF14536.1 KII68040.1 - 0.1 12.5 5.4 0.21 11.5 3.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4441) rve PF00665.21 KII68048.1 - 7.8e-25 87.3 0.0 2.6e-24 85.6 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII68048.1 - 1.3e-17 63.9 0.2 3e-17 62.6 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.1 KII68048.1 - 3e-09 37.2 0.0 8.3e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII68048.1 - 1.1e-07 31.7 0.3 3.8e-07 29.9 0.1 2.0 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII68048.1 - 3.2e-06 26.8 0.0 9.2e-06 25.3 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.1 KII68048.1 - 0.00065 19.1 0.4 0.0024 17.3 0.1 2.2 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.18 KII68048.1 - 0.0024 17.7 0.7 0.0024 17.7 0.5 2.9 2 0 0 2 2 2 1 Zinc knuckle Asp_protease PF09668.5 KII68048.1 - 0.059 12.9 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Ribosomal_L37e PF01907.14 KII68048.1 - 0.11 12.3 3.5 0.27 11.0 2.4 1.7 1 0 0 1 1 1 0 Ribosomal protein L37e Nsp1_C PF05064.8 KII68049.1 - 0.0062 16.1 7.0 0.0062 16.1 4.9 2.1 1 1 0 2 2 2 1 Nsp1-like C-terminal region Spectrin PF00435.16 KII68049.1 - 0.015 15.6 1.4 0.015 15.6 0.9 2.5 2 1 0 2 2 2 0 Spectrin repeat APG6 PF04111.7 KII68049.1 - 0.034 13.2 17.9 0.07 12.1 8.0 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 Snapin_Pallidin PF14712.1 KII68049.1 - 0.035 14.4 2.1 0.035 14.4 1.5 2.8 2 1 1 3 3 3 0 Snapin/Pallidin DUF4140 PF13600.1 KII68049.1 - 0.083 13.3 2.6 2.1 8.8 0.2 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Spc24 PF08286.6 KII68049.1 - 0.095 12.3 12.5 0.11 12.1 2.2 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 WXG100 PF06013.7 KII68049.1 - 0.1 12.5 2.3 6.9 6.7 0.5 2.9 2 1 1 3 3 3 0 Proteins of 100 residues with WXG ATG16 PF08614.6 KII68049.1 - 0.15 11.8 14.6 1.4 8.7 4.6 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SlyX PF04102.7 KII68049.1 - 0.18 12.2 6.4 0.18 12.2 1.1 2.7 2 1 0 2 2 2 0 SlyX TMF_DNA_bd PF12329.3 KII68049.1 - 0.2 11.4 9.1 0.46 10.3 1.0 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.2 KII68049.1 - 0.26 11.1 15.8 0.25 11.2 2.3 2.3 1 1 0 1 1 1 0 Tropomyosin like Tropomyosin PF00261.15 KII68049.1 - 0.32 10.0 11.5 1.4 7.9 3.9 2.1 1 1 1 2 2 2 0 Tropomyosin DUF4164 PF13747.1 KII68049.1 - 0.34 11.0 8.7 8.6 6.5 0.4 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4164) MerR-DNA-bind PF09278.6 KII68049.1 - 0.35 11.2 4.6 0.85 10.0 1.1 2.2 2 0 0 2 2 2 0 MerR, DNA binding FlaC_arch PF05377.6 KII68049.1 - 0.39 10.6 7.9 1.8 8.5 0.2 2.7 3 1 0 3 3 2 0 Flagella accessory protein C (FlaC) DUF16 PF01519.11 KII68049.1 - 0.45 10.7 14.0 0.11 12.6 3.7 2.3 1 1 0 2 2 2 0 Protein of unknown function DUF16 Prefoldin_2 PF01920.15 KII68049.1 - 0.83 9.4 10.2 0.3 10.8 0.7 2.7 2 2 0 2 2 2 0 Prefoldin subunit PspB PF06667.7 KII68049.1 - 1.4 8.9 4.3 2 8.3 0.8 2.4 2 1 0 2 2 2 0 Phage shock protein B IncA PF04156.9 KII68049.1 - 1.6 8.2 11.4 5.5 6.5 3.7 2.3 1 1 1 2 2 2 0 IncA protein DUF724 PF05266.9 KII68049.1 - 2.2 7.8 11.5 0.37 10.3 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) NPV_P10 PF05531.7 KII68049.1 - 2.4 8.4 8.1 6.6 7.0 2.6 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.5 KII68049.1 - 2.5 8.2 13.4 6.5 6.8 3.6 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CorA PF01544.13 KII68049.1 - 3.6 6.5 9.8 4.9 6.1 6.8 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Ax_dynein_light PF10211.4 KII68049.1 - 4.6 7.0 12.5 6.6 6.5 1.0 2.2 1 1 0 2 2 2 0 Axonemal dynein light chain DivIC PF04977.10 KII68049.1 - 5.3 6.6 11.4 2.9 7.4 1.9 2.5 2 1 0 2 2 2 0 Septum formation initiator 4HB_MCP_1 PF12729.2 KII68049.1 - 8.6 5.6 16.9 6.3 6.1 7.5 2.0 1 1 1 2 2 2 0 Four helix bundle sensory module for signal transduction DUF4450 PF14614.1 KII68050.1 - 0.03 13.4 1.5 0.033 13.3 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4450) RmuC PF02646.11 KII68052.1 - 0.025 13.4 1.3 0.084 11.6 0.1 1.8 1 1 1 2 2 2 0 RmuC family ERM PF00769.14 KII68052.1 - 0.031 13.7 1.0 0.31 10.5 0.0 1.9 2 0 0 2 2 2 0 Ezrin/radixin/moesin family bZIP_1 PF00170.16 KII68052.1 - 0.093 12.7 0.9 0.093 12.7 0.6 1.8 2 0 0 2 2 2 0 bZIP transcription factor DUF3552 PF12072.3 KII68052.1 - 0.097 11.8 0.7 0.16 11.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Atg14 PF10186.4 KII68052.1 - 0.11 11.3 1.5 0.14 11.0 1.1 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Cortex-I_coil PF09304.5 KII68052.1 - 0.14 12.2 3.2 1.2 9.2 0.1 2.1 2 0 0 2 2 2 0 Cortexillin I, coiled coil APG6 PF04111.7 KII68052.1 - 0.24 10.3 8.0 0.62 9.0 5.5 1.5 1 1 0 1 1 1 0 Autophagy protein Apg6 Prefoldin_2 PF01920.15 KII68052.1 - 0.35 10.6 6.7 0.13 12.0 1.3 2.1 2 0 0 2 2 2 0 Prefoldin subunit DivIC PF04977.10 KII68052.1 - 1 8.8 3.6 0.46 10.0 0.3 1.9 2 0 0 2 2 2 0 Septum formation initiator ORF6C PF10552.4 KII68052.1 - 1.1 9.0 5.3 2.6 7.8 0.1 2.4 2 1 0 2 2 2 0 ORF6C domain Tropomyosin_1 PF12718.2 KII68052.1 - 1.2 8.9 6.9 4 7.2 4.6 1.8 1 1 0 1 1 1 0 Tropomyosin like DUF972 PF06156.8 KII68052.1 - 1.4 9.3 5.7 0.25 11.7 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Cep57_CLD_2 PF14197.1 KII68052.1 - 1.7 8.6 5.7 11 5.9 0.2 2.2 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Kinetocho_Slk19 PF12709.2 KII68052.1 - 1.8 8.6 9.3 1.5 8.9 0.8 2.9 1 1 2 3 3 3 0 Central kinetochore-associated DUF904 PF06005.7 KII68052.1 - 1.9 8.8 6.9 0.71 10.2 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF904) DUF4200 PF13863.1 KII68052.1 - 2.2 8.2 7.7 0.46 10.4 1.6 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF4468 PF14730.1 KII68053.1 - 0.65 9.7 6.8 0.2 11.3 0.7 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4468) with TBP-like fold CAP PF00188.21 KII68054.1 - 1.5e-05 25.4 0.0 2.2e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.21 KII68055.1 - 1.2e-23 83.9 2.9 1.3e-15 57.9 1.9 2.4 2 1 0 2 2 2 2 Cysteine-rich secretory protein family RVP PF00077.15 KII68056.1 - 2.4e-06 27.3 0.1 4.3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII68056.1 - 4.3e-05 23.2 5.7 0.0013 18.5 0.2 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 KII68056.1 - 0.0003 20.3 8.4 0.013 15.1 1.2 2.7 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII68056.1 - 0.017 15.6 0.0 0.028 14.9 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_2 PF13696.1 KII68056.1 - 0.11 12.0 4.1 0.2 11.2 0.4 2.2 2 0 0 2 2 2 0 Zinc knuckle zf-Mss51 PF13824.1 KII68056.1 - 0.18 11.7 1.8 0.19 11.6 0.2 1.9 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 ZZ PF00569.12 KII68056.1 - 0.32 10.5 5.4 4.8 6.8 3.8 2.5 1 1 0 1 1 1 0 Zinc finger, ZZ type zf-CCHC_5 PF14787.1 KII68056.1 - 0.33 10.4 4.1 0.11 11.9 0.7 1.8 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Copper-fist PF00649.13 KII68056.1 - 5.3 6.3 9.7 3 7.1 4.1 2.1 1 1 1 2 2 2 0 Copper fist DNA binding domain Ykof PF07615.6 KII68059.1 - 0.063 13.4 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 YKOF-related Family Tis11B_N PF04553.7 KII68059.1 - 0.091 12.9 0.5 0.12 12.6 0.3 1.2 1 0 0 1 1 1 0 Tis11B like protein, N terminus EGF_2 PF07974.8 KII68060.1 - 0.22 11.7 30.8 0.14 12.3 7.8 3.0 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.2 KII68060.1 - 0.83 9.8 9.9 2.8 8.1 2.3 3.0 2 0 0 2 2 2 0 Human growth factor-like EGF TBPIP PF07106.8 KII68064.1 - 0.0026 17.3 2.3 0.0037 16.8 1.6 1.2 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMEM154 PF15102.1 KII68064.1 - 0.013 15.2 0.6 0.024 14.3 0.3 1.5 1 1 0 1 1 1 0 TMEM154 protein family DUF912 PF06024.7 KII68064.1 - 0.021 14.8 0.0 0.044 13.8 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Consortin_C PF15281.1 KII68064.1 - 0.024 14.1 0.0 0.061 12.8 0.0 1.7 2 0 0 2 2 2 0 Consortin C-terminus Rifin_STEVOR PF02009.11 KII68064.1 - 0.036 13.7 0.2 0.045 13.3 0.1 1.2 1 0 0 1 1 1 0 Rifin/stevor family Shisa PF13908.1 KII68064.1 - 0.075 13.2 0.1 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4448 PF14610.1 KII68064.1 - 0.08 12.4 0.0 0.1 12.0 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) BatA PF07584.6 KII68064.1 - 0.23 11.6 1.0 15 5.8 0.0 2.4 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal IP_trans PF02121.13 KII68067.1 - 0.022 13.9 0.0 0.042 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol transfer protein DUF3561 PF12084.3 KII68068.1 - 0.059 13.2 0.4 0.059 13.2 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) Corona_NS2A PF05213.7 KII68070.1 - 0.045 13.0 0.4 0.053 12.8 0.2 1.0 1 0 0 1 1 1 0 Coronavirus NS2A protein ATP_bind_4 PF01902.12 KII68070.1 - 0.12 11.6 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 ATP-binding region Metallothio_11 PF02066.10 KII68070.1 - 0.15 11.9 3.2 0.24 11.2 2.2 1.4 1 1 0 1 1 1 0 Metallothionein family 11 GRAM PF02893.15 KII68071.1 - 0.093 12.2 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 GRAM domain Pex24p PF06398.6 KII68073.1 - 6.4 5.4 10.3 12 4.6 7.1 1.4 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin Pex24p PF06398.6 KII68074.1 - 6.4 5.4 10.3 12 4.6 7.1 1.4 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF4132 PF13569.1 KII68075.1 - 0.028 13.9 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4132) FLYWCH PF04500.11 KII68076.1 - 3.8e-05 23.4 2.8 7e-05 22.6 1.9 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain HTH_29 PF13551.1 KII68081.1 - 9.8e-07 28.9 0.1 1.4e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_33 PF13592.1 KII68081.1 - 4.3e-05 22.9 0.0 7.3e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII68081.1 - 6.2e-05 22.5 0.1 0.25 11.0 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII68081.1 - 0.00074 19.4 0.1 0.51 10.4 0.0 2.4 2 1 0 2 2 2 2 Helix-turn-helix domain TrmB PF01978.14 KII68081.1 - 0.00078 19.1 0.0 0.0082 15.8 0.0 2.4 2 1 1 3 3 3 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.7 KII68081.1 - 0.00081 18.9 0.8 0.15 11.7 0.1 2.7 2 1 0 2 2 2 1 HTH domain PAX PF00292.13 KII68081.1 - 0.00081 19.0 0.1 0.0011 18.6 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_Tc3_2 PF01498.13 KII68081.1 - 0.004 17.1 0.1 0.014 15.4 0.0 1.9 1 1 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII68081.1 - 0.018 15.8 0.0 0.032 15.0 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain UPF0242 PF06785.6 KII68081.1 - 0.054 12.1 0.0 0.059 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) HTH_Tnp_IS630 PF01710.11 KII68081.1 - 0.054 13.1 0.1 0.1 12.2 0.1 1.5 1 1 0 1 1 1 0 Transposase Arg_repressor PF01316.16 KII68081.1 - 0.083 12.4 0.0 0.23 11.0 0.0 1.8 1 1 0 1 1 1 0 Arginine repressor, DNA binding domain DUF2997 PF11211.3 KII68081.1 - 0.22 10.9 1.7 0.97 8.8 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2997) CHB_HEX_C PF03174.8 KII68082.1 - 0.03 14.1 1.2 0.097 12.5 0.2 2.1 2 1 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 KII68082.1 - 0.043 13.9 0.1 0.084 12.9 0.1 1.6 1 0 0 1 1 1 0 Fn3 associated CHB_HEX_C_1 PF13290.1 KII68082.1 - 0.087 12.6 1.0 0.15 11.8 0.3 1.9 2 1 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Sec7 PF01369.15 KII68083.1 - 2.1e-41 141.6 1.5 2.1e-41 141.6 1.0 1.9 2 0 0 2 2 2 1 Sec7 domain WW PF00397.21 KII68084.1 - 0.00081 19.2 1.4 0.0016 18.2 1.0 1.6 1 0 0 1 1 1 1 WW domain BRICHOS PF04089.9 KII68084.1 - 0.03 14.1 0.1 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 BRICHOS domain PRESAN PF09687.5 KII68087.1 - 0.19 11.7 3.4 0.62 10.1 0.2 2.5 3 0 0 3 3 3 0 Plasmodium RESA N-terminal PRESAN PF09687.5 KII68089.1 - 0.029 14.4 4.4 0.055 13.5 0.4 2.5 3 0 0 3 3 3 0 Plasmodium RESA N-terminal RNaseH_C PF09293.5 KII68089.1 - 0.039 13.8 0.4 0.061 13.2 0.3 1.3 1 0 0 1 1 1 0 T4 RNase H, C terminal DUF3689 PF12463.3 KII68090.1 - 0.039 12.7 0.1 0.041 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3689) DUF3221 PF11518.3 KII68091.1 - 0.1 12.2 1.1 0.3 10.7 0.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3221) DUF2811 PF10929.3 KII68096.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) Atx10homo_assoc PF09759.4 KII68096.1 - 0.13 11.9 0.2 0.17 11.6 0.2 1.2 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain RVT_1 PF00078.22 KII68097.1 - 3.2e-26 92.0 0.1 3.1e-25 88.8 0.0 2.6 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII68097.1 - 4.7e-09 36.0 0.0 1.4e-08 34.5 0.0 1.8 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII68097.1 - 0.00013 22.3 0.0 0.0003 21.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2B PF12384.3 KII68097.1 - 0.0084 15.4 0.0 0.021 14.1 0.0 1.6 1 0 0 1 1 1 1 Ty3 transposon peptidase Peptidase_A2E PF12382.3 KII68097.1 - 0.009 15.8 0.1 0.034 13.9 0.1 2.0 1 0 0 1 1 1 1 Retrotransposon peptidase Asp_protease PF09668.5 KII68097.1 - 0.076 12.5 0.2 0.34 10.4 0.1 2.0 1 1 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII68097.1 - 0.17 11.6 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII68097.1 - 0.21 11.3 5.1 3.6 7.3 0.3 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.1 KII68097.1 - 0.92 9.0 14.0 0.19 11.2 1.9 2.5 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.18 KII68097.1 - 4.8 7.2 7.5 0.19 11.7 0.4 2.3 2 0 0 2 2 2 0 Zinc knuckle Pentapeptide PF00805.17 KII68098.1 - 0.13 11.5 0.7 0.24 10.6 0.5 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) Tetraspannin PF00335.15 KII68099.1 - 0.0057 15.9 0.4 0.0064 15.7 0.3 1.2 1 0 0 1 1 1 1 Tetraspanin family Prominin PF05478.6 KII68099.1 - 0.054 11.0 1.3 0.054 11.0 0.9 1.1 1 0 0 1 1 1 0 Prominin MLANA PF14991.1 KII68099.1 - 0.082 12.9 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein melan-A VKOR PF07884.9 KII68099.1 - 0.21 11.4 5.5 0.25 11.1 3.8 1.1 1 0 0 1 1 1 0 Vitamin K epoxide reductase family Tmemb_9 PF05434.6 KII68099.1 - 0.77 9.4 2.5 1.1 8.9 1.8 1.4 1 1 0 1 1 1 0 TMEM9 CD34_antigen PF06365.7 KII68100.1 - 0.01 15.4 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4448 PF14610.1 KII68100.1 - 0.13 11.7 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Phosphorylase PF00343.15 KII68102.1 - 6.9e-230 764.6 0.0 8.7e-230 764.3 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Phosphorylase PF00343.15 KII68103.1 - 2.4e-87 293.5 1.6 2.7e-87 293.3 1.1 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase BCS1_N PF08740.6 KII68104.1 - 3e-36 124.7 0.1 5.2e-36 124.0 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 KII68104.1 - 3.2e-16 59.7 0.0 5.3e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KII68104.1 - 0.00037 21.3 0.0 0.00081 20.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII68104.1 - 0.00096 19.1 0.2 0.0027 17.7 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 KII68104.1 - 0.0038 16.9 0.1 0.012 15.3 0.0 1.8 2 0 0 2 2 2 1 Archaeal ATPase AAA_22 PF13401.1 KII68104.1 - 0.0048 17.0 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.1 KII68104.1 - 0.0072 16.6 0.3 0.021 15.1 0.1 1.8 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KII68104.1 - 0.008 15.6 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KII68104.1 - 0.0087 15.1 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 KII68104.1 - 0.0097 15.0 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_5 PF07728.9 KII68104.1 - 0.012 15.3 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.1 KII68104.1 - 0.014 14.9 0.2 0.042 13.4 0.1 1.7 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.17 KII68104.1 - 0.015 15.4 0.1 0.045 13.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase KaiC PF06745.8 KII68104.1 - 0.016 14.3 0.0 0.028 13.5 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_11 PF13086.1 KII68104.1 - 0.019 14.5 0.0 0.16 11.5 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.1 KII68104.1 - 0.037 13.5 0.0 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.10 KII68104.1 - 0.037 12.7 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein ABC_tran PF00005.22 KII68104.1 - 0.044 14.0 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.1 KII68104.1 - 0.047 14.0 0.0 0.091 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KII68104.1 - 0.071 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 KII68104.1 - 0.092 12.1 0.1 0.28 10.5 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_14 PF13173.1 KII68104.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KII68104.1 - 0.15 11.9 0.1 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 KII68104.1 - 0.17 10.5 0.0 0.26 9.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus PDZ_2 PF13180.1 KII68105.1 - 0.00027 20.7 0.7 0.00062 19.6 0.4 1.9 1 1 0 1 1 1 1 PDZ domain PDZ PF00595.19 KII68105.1 - 0.00041 20.4 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FAA_hydrolase_N PF09298.6 KII68105.1 - 0.033 14.1 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal Btz PF09405.5 KII68105.1 - 1 9.3 5.0 1.8 8.6 3.5 1.4 1 0 0 1 1 1 0 CASC3/Barentsz eIF4AIII binding Arfaptin PF06456.8 KII68106.1 - 0.042 13.2 0.3 0.042 13.2 0.2 1.8 2 0 0 2 2 2 0 Arfaptin-like domain Choline_transpo PF04515.7 KII68107.1 - 0.009 14.7 9.5 0.01 14.6 6.6 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter FixQ PF05545.6 KII68108.1 - 0.31 10.7 1.3 0.56 9.8 0.9 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Baculo_11_kDa PF06143.6 KII68108.1 - 1.4 8.3 6.3 12 5.3 2.0 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family DDE_1 PF03184.14 KII68109.1 - 1.9e-31 108.8 1.0 2.5e-21 75.8 0.1 2.9 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF1015 PF06245.6 KII68109.1 - 0.05 12.0 0.0 0.076 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) ABC2_membrane PF01061.19 KII68110.1 - 1.5e-21 76.5 22.0 1.5e-21 76.5 15.3 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 KII68110.1 - 5.9e-06 25.5 25.9 7.9e-06 25.1 18.0 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 KII68110.1 - 0.0095 14.8 11.6 0.011 14.5 8.1 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein UDP-g_GGTase PF06427.6 KII68116.1 - 1.1e-41 142.4 0.0 3.5e-41 140.8 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 KII68117.1 - 1e-06 28.2 2.4 1.6e-06 27.6 1.7 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 PDZ_2 PF13180.1 KII68119.1 - 3.3e-05 23.6 0.0 5.3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KII68119.1 - 0.00066 19.8 0.0 0.0011 19.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 KII68119.1 - 0.025 14.3 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain Metallophos PF00149.23 KII68121.1 - 6e-42 143.3 0.1 7.4e-42 143.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CoA_binding PF02629.14 KII68122.1 - 5.5e-27 94.1 0.0 1.1e-26 93.1 0.0 1.5 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.14 KII68122.1 - 7.4e-15 54.8 0.0 1.2e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 CoA-ligase GFO_IDH_MocA PF01408.17 KII68122.1 - 4.1e-05 24.0 0.0 0.0015 19.0 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding_2 PF13380.1 KII68122.1 - 0.0003 20.9 0.2 0.0011 19.0 0.0 2.0 3 0 0 3 3 3 1 CoA binding domain IL31 PF15209.1 KII68126.1 - 0.0035 16.9 0.1 0.0054 16.3 0.1 1.3 1 0 0 1 1 1 1 Interleukin 31 DUF4460 PF14687.1 KII68128.1 - 0.041 13.6 0.8 0.041 13.6 0.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4460) OSCP PF00213.13 KII68128.1 - 0.044 13.6 1.0 0.061 13.1 0.6 1.4 1 1 0 1 1 1 0 ATP synthase delta (OSCP) subunit YwqJ-deaminase PF14431.1 KII68128.1 - 0.076 12.8 0.1 0.13 12.1 0.0 1.4 1 1 0 1 1 1 0 YwqJ-like deaminase SAS4 PF15460.1 KII68128.1 - 0.13 12.1 1.6 2.2 8.2 0.1 2.4 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 MecA_N PF05223.6 KII68128.1 - 0.32 11.0 4.4 0.18 11.8 0.6 2.1 1 1 1 2 2 2 0 NTF2-like N-terminal transpeptidase domain Cyclin_C PF02984.14 KII68128.1 - 0.5 10.3 2.8 1.2 9.0 0.3 2.5 1 1 1 2 2 2 0 Cyclin, C-terminal domain ComGG PF14173.1 KII68129.1 - 0.007 16.5 0.2 0.009 16.1 0.1 1.2 1 0 0 1 1 1 1 ComG operon protein 7 Arrestin_C PF02752.17 KII68129.1 - 0.043 13.9 0.1 0.058 13.4 0.1 1.3 1 1 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain CENP-I PF07778.6 KII68130.1 - 0.12 10.5 0.1 8 4.5 0.1 2.0 1 1 1 2 2 2 0 Mis6 Enterotoxin_a PF01375.12 KII68131.1 - 0.016 14.5 0.1 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 Heat-labile enterotoxin alpha chain GATase PF00117.23 KII68132.1 - 2.5e-32 111.9 0.0 5.7e-32 110.7 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.17 KII68132.1 - 3.3e-25 87.6 0.5 1e-15 57.1 0.0 3.1 2 1 0 2 2 2 2 GMP synthase C terminal domain Peptidase_C26 PF07722.8 KII68132.1 - 5.2e-10 39.1 0.0 1.1e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.12 KII68132.1 - 2.3e-07 29.9 0.2 0.0012 17.8 0.0 2.2 2 0 0 2 2 2 2 NAD synthase PAPS_reduct PF01507.14 KII68132.1 - 0.0004 20.2 0.0 0.0012 18.7 0.0 1.8 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family QueC PF06508.8 KII68132.1 - 0.0021 17.3 0.0 0.0069 15.6 0.0 1.8 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 KII68132.1 - 0.0031 17.0 0.0 0.0055 16.2 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.11 KII68132.1 - 0.0095 14.5 0.1 0.036 12.6 0.0 1.9 2 0 0 2 2 2 1 tRNA methyl transferase ATP_bind_3 PF01171.15 KII68132.1 - 0.017 14.6 0.1 0.9 9.0 0.0 2.9 3 0 0 3 3 3 0 PP-loop family DUF773 PF05600.7 KII68133.1 - 1.7e-15 56.8 0.4 8.4e-11 41.3 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF773) Med9 PF07544.8 KII68133.1 - 0.0043 16.7 0.2 0.01 15.5 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 TMF_DNA_bd PF12329.3 KII68133.1 - 0.006 16.3 1.9 0.0078 15.9 0.4 1.8 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding EHN PF06441.7 KII68133.1 - 0.0089 15.9 0.9 0.023 14.5 0.1 2.0 2 1 0 2 2 2 1 Epoxide hydrolase N terminus ATG16 PF08614.6 KII68133.1 - 0.0098 15.7 0.9 0.015 15.1 0.6 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) EAP30 PF04157.11 KII68133.1 - 0.01 14.9 0.4 0.019 14.0 0.2 1.5 1 1 0 1 1 1 0 EAP30/Vps36 family DASH_Spc34 PF08657.5 KII68133.1 - 0.013 15.2 0.8 0.024 14.3 0.3 1.6 1 1 0 1 1 1 0 DASH complex subunit Spc34 DUF2972 PF11186.3 KII68133.1 - 0.033 14.0 2.4 0.1 12.4 1.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2972) Golgin_A5 PF09787.4 KII68133.1 - 0.054 12.0 0.2 0.084 11.3 0.1 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Orbi_NS3 PF01616.11 KII68133.1 - 0.073 12.0 0.0 0.097 11.6 0.0 1.2 1 0 0 1 1 1 0 Orbivirus NS3 Tektin PF03148.9 KII68133.1 - 0.074 11.5 0.1 0.1 11.1 0.1 1.2 1 0 0 1 1 1 0 Tektin family MRG PF05712.8 KII68133.1 - 0.078 11.8 0.3 0.45 9.3 0.0 2.1 2 0 0 2 2 2 0 MRG Synaptobrevin PF00957.16 KII68133.1 - 0.081 12.5 0.3 0.15 11.6 0.2 1.4 1 0 0 1 1 1 0 Synaptobrevin Reo_sigmaC PF04582.7 KII68133.1 - 0.083 12.0 0.1 0.12 11.5 0.1 1.3 1 1 0 1 1 1 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 KII68133.1 - 0.087 12.5 2.7 0.17 11.6 1.1 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.5 KII68133.1 - 0.09 12.8 1.3 0.27 11.3 0.9 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF2758 PF10957.3 KII68133.1 - 0.3 10.9 1.5 10 6.0 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2758) TBPIP PF07106.8 KII68133.1 - 0.31 10.5 4.6 4.5 6.7 0.8 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Seryl_tRNA_N PF02403.17 KII68133.1 - 0.38 10.7 3.5 1.4 8.9 0.8 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Fzo_mitofusin PF04799.8 KII68133.1 - 0.46 9.8 3.4 1.2 8.4 0.2 2.1 2 0 0 2 2 2 0 fzo-like conserved region Prefoldin_2 PF01920.15 KII68133.1 - 0.87 9.3 5.3 0.58 9.9 1.2 2.3 3 0 0 3 3 3 0 Prefoldin subunit Brix PF04427.13 KII68136.1 - 1.9e-26 92.9 0.6 2.2e-26 92.6 0.4 1.1 1 0 0 1 1 1 1 Brix domain EcoRII-C PF09019.6 KII68136.1 - 0.032 14.0 0.1 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 EcoRII C terminal CH PF00307.26 KII68137.1 - 1.9e-29 101.8 2.2 3.4e-16 59.2 0.1 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KII68137.1 - 4.5e-08 32.6 0.2 0.019 14.6 0.0 3.6 3 1 1 4 4 4 2 CAMSAP CH domain Filamin PF00630.14 KII68137.1 - 0.02 15.4 7.1 0.12 12.9 0.2 3.4 3 1 0 3 3 3 0 Filamin/ABP280 repeat Filamin PF00630.14 KII68138.1 - 8.2e-18 64.8 3.1 5.5e-11 42.9 0.0 3.4 2 1 1 3 3 3 3 Filamin/ABP280 repeat Y_Y_Y PF07495.8 KII68138.1 - 0.0035 17.0 1.1 1.1 9.1 0.4 2.9 2 1 0 2 2 2 2 Y_Y_Y domain TRP_N PF14558.1 KII68139.1 - 0.11 12.5 0.0 1.1 9.2 0.0 1.9 2 0 0 2 2 2 0 ML-like domain zf-CCCH PF00642.19 KII68140.1 - 2.3e-07 30.3 20.1 1.8e-05 24.2 1.2 3.5 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CSL PF05207.8 KII68140.1 - 0.048 13.1 0.1 0.1 12.1 0.1 1.6 1 0 0 1 1 1 0 CSL zinc finger Mss4 PF04421.8 KII68140.1 - 0.078 12.8 0.8 1 9.2 0.0 2.3 2 0 0 2 2 2 0 Mss4 protein KilA-N PF04383.8 KII68142.1 - 0.051 13.1 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 KilA-N domain Mpp10 PF04006.7 KII68145.1 - 0.0039 15.6 0.4 0.0044 15.4 0.3 1.0 1 0 0 1 1 1 1 Mpp10 protein V-set_CD47 PF08204.6 KII68145.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain HTH_29 PF13551.1 KII68146.1 - 3.5e-06 27.1 0.0 5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII68146.1 - 8.9e-06 25.1 0.0 1.8e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII68146.1 - 0.00021 21.2 0.0 0.00038 20.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 KII68146.1 - 0.071 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase MR_MLE_C PF13378.1 KII68147.1 - 1.3e-27 95.9 0.0 1.5e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like SAM_1 PF00536.25 KII68148.1 - 5.5e-08 32.8 0.4 0.00053 20.1 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KII68148.1 - 9.8e-07 28.5 0.8 0.0037 17.0 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) DUF2025 PF09634.5 KII68148.1 - 0.046 13.4 0.8 4.6 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2025) FA_FANCE PF11510.3 KII68148.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Fanconi Anaemia group E protein FANCE DNA_pol3_a_NI PF14480.1 KII68149.1 - 0.016 14.8 0.9 0.029 14.0 0.6 1.5 1 1 0 1 1 1 0 DNA polymerase III polC-type N-terminus I PKK PF12474.3 KII68149.1 - 0.028 14.1 3.7 0.035 13.8 2.6 1.1 1 0 0 1 1 1 0 Polo kinase kinase NABP PF07990.7 KII68150.1 - 0.00055 19.3 0.1 0.0011 18.3 0.0 1.5 2 0 0 2 2 2 1 Nucleic acid binding protein NABP Sdh_cyt PF01127.17 KII68151.1 - 0.098 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit MTBP_C PF14920.1 KII68152.1 - 2.9e-16 59.7 0.5 3.8e-16 59.3 0.3 1.1 1 0 0 1 1 1 1 MDM2-binding Inos-1-P_synth PF01658.12 KII68152.1 - 0.0057 16.4 1.1 0.0087 15.8 0.8 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase RRS1 PF04939.7 KII68154.1 - 1.4e-34 118.9 5.3 2.1e-34 118.3 3.7 1.2 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) Baculo_p48 PF04878.8 KII68155.1 - 0.043 12.7 0.1 0.061 12.2 0.1 1.2 1 0 0 1 1 1 0 Baculovirus P48 protein BRCT PF00533.21 KII68155.1 - 0.1 12.7 0.2 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain EcoRI_methylase PF13651.1 KII68156.1 - 0.048 12.7 0.0 0.056 12.5 0.0 1.1 1 0 0 1 1 1 0 Adenine-specific methyltransferase EcoRI Rep_3 PF01051.16 KII68157.1 - 1.4e-20 73.8 0.2 1.8e-20 73.5 0.2 1.1 1 0 0 1 1 1 1 Initiator Replication protein Angiomotin_C PF12240.3 KII68157.1 - 6.5e-05 22.5 0.1 0.0001 21.8 0.0 1.2 1 0 0 1 1 1 1 Angiomotin C terminal HTH_36 PF13730.1 KII68157.1 - 0.026 14.6 0.1 0.095 12.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain CbiA PF01656.18 KII68159.1 - 2.4e-09 36.8 0.0 4.7e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.13 KII68159.1 - 0.0032 16.7 0.0 0.005 16.0 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family HTH_Crp_2 PF13545.1 KII68159.1 - 0.027 14.2 0.0 0.069 12.9 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain RPA_C PF08784.6 KII68159.1 - 0.054 13.9 0.1 0.21 12.0 0.0 1.9 2 0 0 2 2 2 0 Replication protein A C terminal Trans_reg_C PF00486.23 KII68161.1 - 2.3e-10 40.2 0.0 1e-09 38.1 0.0 1.9 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal PapD_N PF00345.15 KII68163.1 - 0.0014 18.3 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain Mnd1 PF03962.10 KII68166.1 - 7.7e-60 201.7 9.0 8.7e-60 201.6 6.2 1.0 1 0 0 1 1 1 1 Mnd1 family TBPIP PF07106.8 KII68166.1 - 0.00019 21.0 4.3 0.00031 20.3 3.0 1.3 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DivIVA PF05103.8 KII68166.1 - 0.0002 21.4 0.9 0.0002 21.4 0.6 2.1 2 0 0 2 2 2 1 DivIVA protein DUF342 PF03961.8 KII68166.1 - 0.003 16.0 2.7 0.0041 15.6 1.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF342) DUF2458 PF10454.4 KII68166.1 - 0.0053 16.6 6.0 0.0059 16.5 2.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2458) Fmp27_WPPW PF10359.4 KII68166.1 - 0.0055 15.1 3.2 0.0066 14.9 2.2 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF904 PF06005.7 KII68166.1 - 0.027 14.7 0.4 0.027 14.7 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Penicillinase_R PF03965.11 KII68166.1 - 0.05 13.6 0.9 0.087 12.9 0.3 1.7 2 0 0 2 2 1 0 Penicillinase repressor CesA PF11439.3 KII68166.1 - 0.074 12.9 2.8 0.097 12.6 1.1 1.8 2 0 0 2 2 1 0 Type III secretion system filament chaperone CesA Fib_alpha PF08702.5 KII68166.1 - 0.079 13.0 4.7 1.4 9.0 0.3 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DsrD PF08679.6 KII68166.1 - 0.079 12.9 0.3 0.21 11.6 0.2 1.8 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) DUF4375 PF14300.1 KII68166.1 - 0.12 12.3 3.1 0.34 10.8 1.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) FUR PF01475.14 KII68166.1 - 0.13 12.1 2.3 0.22 11.4 0.4 2.5 1 1 0 2 2 2 0 Ferric uptake regulator family Syntaxin-6_N PF09177.6 KII68166.1 - 0.31 11.4 3.8 1.2 9.6 2.4 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal RasGAP PF00616.14 KII68166.1 - 0.35 10.5 4.6 1.1 8.9 3.2 1.7 1 1 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase IncA PF04156.9 KII68166.1 - 0.39 10.2 13.2 0.021 14.3 5.5 1.5 2 0 0 2 2 2 0 IncA protein Snapin_Pallidin PF14712.1 KII68166.1 - 0.47 10.7 5.0 0.55 10.5 0.8 2.6 1 1 2 3 3 3 0 Snapin/Pallidin Syntaxin PF00804.20 KII68166.1 - 1.1 9.4 5.5 8.2 6.6 3.8 2.1 1 1 0 1 1 1 0 Syntaxin AAA_23 PF13476.1 KII68166.1 - 1.2 9.3 9.4 1.9 8.7 6.5 1.3 1 0 0 1 1 1 0 AAA domain DivIC PF04977.10 KII68166.1 - 2.6 7.6 7.5 1.6 8.2 0.7 2.7 1 1 2 3 3 3 0 Septum formation initiator Occludin_ELL PF07303.8 KII68166.1 - 6.9 7.4 12.9 0.26 12.0 3.9 2.2 2 1 1 3 3 2 0 Occludin homology domain Plant_vir_prot PF01307.12 KII68167.1 - 0.01 15.5 0.1 0.016 14.9 0.1 1.3 1 0 0 1 1 1 0 Plant viral movement protein rve PF00665.21 KII68168.1 - 6.8e-17 61.6 0.0 1.5e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve PF00665.21 KII68171.1 - 0.00033 20.7 0.3 0.28 11.2 0.1 2.5 2 0 0 2 2 2 2 Integrase core domain Tetraspannin PF00335.15 KII68173.1 - 4.4e-07 29.4 20.7 9.6e-07 28.2 14.4 1.6 1 1 0 1 1 1 1 Tetraspanin family Asp_protease PF09668.5 KII68175.1 - 0.027 14.0 0.1 0.048 13.2 0.0 1.5 1 1 0 1 1 1 0 Aspartyl protease Med7 PF05983.6 KII68176.1 - 0.024 14.3 0.0 0.028 14.1 0.0 1.1 1 0 0 1 1 1 0 MED7 protein rve PF00665.21 KII68176.1 - 0.073 13.1 0.0 0.13 12.3 0.0 1.3 1 1 0 1 1 1 0 Integrase core domain PurA PF04845.8 KII68177.1 - 0.037 13.1 1.0 0.069 12.2 0.7 1.5 1 1 0 1 1 1 0 PurA ssDNA and RNA-binding protein HTH_22 PF13309.1 KII68178.1 - 0.28 10.9 2.3 6.4 6.6 0.1 2.8 3 0 0 3 3 3 0 HTH domain Hexokinase_2 PF03727.11 KII68179.1 - 5.4e-46 156.7 0.2 6.2e-46 156.5 0.2 1.0 1 0 0 1 1 1 1 Hexokinase Arm PF00514.18 KII68182.1 - 1.5e-16 59.5 2.0 1.4e-06 27.9 0.1 6.2 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KII68182.1 - 4.4e-09 36.5 0.0 0.005 17.2 0.0 4.5 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.1 KII68182.1 - 4.6e-08 33.2 0.0 0.011 16.0 0.0 4.3 4 1 0 4 4 4 3 HEAT repeats HEAT PF02985.17 KII68182.1 - 3.8e-05 23.4 0.3 7.5 6.9 0.1 4.8 4 0 0 4 4 4 1 HEAT repeat Atx10homo_assoc PF09759.4 KII68182.1 - 0.019 14.6 0.9 0.064 12.9 0.0 2.3 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain HEAT_PBS PF03130.11 KII68182.1 - 0.13 12.7 0.0 0.51 10.9 0.0 2.1 1 0 0 1 1 1 0 PBS lyase HEAT-like repeat Arm PF00514.18 KII68183.1 - 2e-07 30.5 0.8 0.001 18.7 0.0 4.1 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KII68183.1 - 0.07 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 HEAT repeats DDE_3 PF13358.1 KII68187.1 - 2e-10 40.5 0.0 2.2e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Arm PF00514.18 KII68190.1 - 9.9e-06 25.2 0.9 0.51 10.2 0.0 3.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat Phage_GP20 PF06810.6 KII68191.1 - 0.01 15.2 0.1 0.01 15.2 0.1 1.5 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF1771 PF08590.5 KII68191.1 - 0.12 12.4 1.2 0.22 11.5 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) Arm PF00514.18 KII68192.1 - 2.3e-07 30.4 0.1 0.049 13.4 0.0 3.9 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KII68192.1 - 0.03 13.4 1.4 0.077 12.0 0.1 2.2 1 1 1 2 2 2 0 Armadillo-like IpaB_EvcA PF03278.8 KII68194.1 - 0.051 12.8 1.6 0.87 8.7 0.2 2.0 1 1 1 2 2 2 0 IpaB/EvcA family Herpes_BBRF1 PF04793.7 KII68195.1 - 0.027 13.2 0.0 0.03 13.1 0.0 1.1 1 0 0 1 1 1 0 BRRF1-like protein SNAP PF14938.1 KII68198.1 - 6.2e-73 245.3 14.6 7.3e-73 245.1 10.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.1 KII68198.1 - 2.9e-06 26.6 4.8 0.54 10.1 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII68198.1 - 2.1e-05 24.3 5.2 0.0033 17.3 0.3 3.2 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.1 KII68198.1 - 0.0013 19.0 5.8 9.8 6.8 0.1 5.2 4 2 1 6 6 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 KII68198.1 - 0.0086 15.7 15.9 1.1 9.2 0.0 6.2 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 KII68198.1 - 0.027 14.8 8.0 0.11 12.8 0.3 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 KII68198.1 - 0.047 14.3 0.5 13 6.7 0.2 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 KII68198.1 - 0.073 13.7 3.3 13 6.5 0.0 4.5 5 0 0 5 5 5 0 Sel1 repeat TPR_2 PF07719.12 KII68198.1 - 0.12 12.3 16.2 4 7.5 0.2 5.4 4 1 2 6 6 6 0 Tetratricopeptide repeat Sec5 PF15469.1 KII68198.1 - 0.36 10.5 4.9 7.1 6.3 0.1 3.0 2 2 0 2 2 2 0 Exocyst complex component Sec5 TPR_11 PF13414.1 KII68198.1 - 0.46 10.1 12.1 12 5.6 2.0 4.1 2 2 0 2 2 2 0 TPR repeat Methyltransf_28 PF02636.12 KII68199.1 - 4.9e-09 35.9 0.0 5.4e-09 35.8 0.0 1.0 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase UPF0253 PF06786.7 KII68199.1 - 0.0072 16.4 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0253) Methyltransf_28 PF02636.12 KII68200.1 - 6.5e-20 71.5 0.0 8.2e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase HALZ PF02183.13 KII68201.1 - 0.096 12.4 5.0 0.12 12.1 1.4 2.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF3450 PF11932.3 KII68201.1 - 0.15 11.3 19.5 0.67 9.1 5.3 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF3450) Reo_sigmaC PF04582.7 KII68201.1 - 0.29 10.2 19.2 0.68 9.0 3.9 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein LLC1 PF14945.1 KII68201.1 - 9 6.6 10.1 29 4.9 0.3 4.2 2 2 1 4 4 4 0 Normal lung function maintenance, Low in Lung Cancer 1 protein rve PF00665.21 KII68202.1 - 1.6e-24 86.2 0.0 5.1e-24 84.6 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII68202.1 - 3.2e-09 36.4 0.2 8.5e-09 35.0 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.5 KII68202.1 - 0.00015 21.1 0.0 0.00032 20.0 0.0 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII68202.1 - 0.00025 20.5 0.1 0.0034 16.8 0.1 2.5 2 0 0 2 2 2 1 Integrase core domain DUF904 PF06005.7 KII68202.1 - 0.0011 19.2 3.2 0.23 11.7 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF904) RVP PF00077.15 KII68203.1 - 1.6e-07 31.1 0.0 3.4e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.22 KII68203.1 - 1.5e-06 27.6 0.0 1.7e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.18 KII68203.1 - 0.00034 20.3 5.3 0.088 12.7 0.5 2.6 2 0 0 2 2 2 2 Zinc knuckle RVP_2 PF08284.6 KII68203.1 - 0.016 15.1 0.0 0.031 14.2 0.0 1.5 1 1 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII68203.1 - 0.03 14.8 0.0 0.073 13.5 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease Spuma_A9PTase PF03539.9 KII68203.1 - 0.031 14.1 0.0 0.14 12.0 0.0 2.0 1 1 1 2 2 2 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII68203.1 - 0.14 11.9 0.1 0.44 10.3 0.1 1.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII68203.1 - 0.15 11.7 8.9 0.67 9.6 0.7 3.0 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_3 PF13917.1 KII68203.1 - 0.4 10.4 7.1 0.95 9.2 0.3 2.5 1 1 1 2 2 2 0 Zinc knuckle CK_II_beta PF01214.13 KII68204.1 - 8.1e-38 129.7 0.2 1.1e-37 129.2 0.1 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit ABC_tran PF00005.22 KII68206.1 - 1.9e-51 173.9 0.1 9.2e-29 100.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 KII68206.1 - 1.4e-45 155.8 51.7 1.5e-24 86.9 15.0 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 KII68206.1 - 1.5e-11 43.9 6.9 0.0052 16.0 0.1 4.4 3 1 1 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KII68206.1 - 1.9e-11 44.4 12.3 0.0015 18.5 1.3 5.3 3 2 0 4 4 4 3 AAA domain AAA_16 PF13191.1 KII68206.1 - 3.1e-06 27.3 0.0 0.02 14.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 KII68206.1 - 1.9e-05 24.8 0.0 0.22 11.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain NACHT PF05729.7 KII68206.1 - 2e-05 24.3 0.1 0.011 15.4 0.0 2.9 2 0 0 2 2 2 1 NACHT domain Miro PF08477.8 KII68206.1 - 3e-05 24.5 0.2 0.091 13.2 0.0 2.9 3 0 0 3 3 2 2 Miro-like protein AAA_29 PF13555.1 KII68206.1 - 0.00029 20.3 0.8 0.35 10.4 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 KII68206.1 - 0.00031 20.6 0.1 0.23 11.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.1 KII68206.1 - 0.00032 19.8 4.1 0.00085 18.4 1.8 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 KII68206.1 - 0.00033 20.0 0.0 0.81 9.0 0.0 2.7 3 0 0 3 3 2 2 AAA domain MobB PF03205.9 KII68206.1 - 0.00066 19.4 1.0 1.1 8.9 0.0 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 KII68206.1 - 0.0011 18.4 0.2 1.3 8.4 0.1 2.5 2 0 0 2 2 2 2 FtsK/SpoIIIE family ABC_ATPase PF09818.4 KII68206.1 - 0.0014 17.2 0.6 0.011 14.4 0.1 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class DUF258 PF03193.11 KII68206.1 - 0.0034 16.5 0.2 2 7.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 KII68206.1 - 0.004 16.0 0.0 0.86 8.4 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF87 PF01935.12 KII68206.1 - 0.0061 16.3 1.6 0.25 11.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_17 PF13207.1 KII68206.1 - 0.0085 16.9 1.5 4.2 8.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.1 KII68206.1 - 0.01 16.1 9.2 1.3 9.3 4.8 2.9 2 1 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KII68206.1 - 0.011 15.4 0.4 0.82 9.3 0.0 2.9 2 1 0 2 2 2 0 Archaeal ATPase Viral_helicase1 PF01443.13 KII68206.1 - 0.012 15.0 0.1 2 7.9 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase cobW PF02492.14 KII68206.1 - 0.015 14.7 1.3 1.3 8.4 0.2 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.17 KII68206.1 - 0.016 14.0 0.0 4.6 5.9 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Dynamin_N PF00350.18 KII68206.1 - 0.03 14.1 0.8 8.4 6.1 0.4 2.6 2 0 0 2 2 2 0 Dynamin family Zeta_toxin PF06414.7 KII68206.1 - 0.033 13.2 0.1 7 5.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.1 KII68206.1 - 0.033 14.4 0.0 9.2 6.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 KII68206.1 - 0.04 13.3 0.4 2.9 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA-like domain TrwB_AAD_bind PF10412.4 KII68206.1 - 0.043 12.4 0.2 5.3 5.5 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.1 KII68206.1 - 0.06 12.9 0.0 17 4.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.9 KII68206.1 - 0.083 12.6 0.7 8.1 6.1 0.0 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.4 KII68206.1 - 0.14 11.0 0.0 5.9 5.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.1 KII68206.1 - 0.15 11.9 0.0 4.2 7.2 0.0 2.6 3 0 0 3 3 2 0 AAA domain ABC_tran PF00005.22 KII68207.1 - 2.7e-17 63.3 0.0 7.6e-17 61.8 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.14 KII68207.1 - 8.3e-05 21.9 0.1 0.0001 21.5 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KII68207.1 - 0.0088 16.0 0.3 0.0099 15.8 0.2 1.3 1 0 0 1 1 1 1 AAA domain ABC_ATPase PF09818.4 KII68207.1 - 0.05 12.1 0.3 0.062 11.8 0.2 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Mistic PF11458.3 KII68207.1 - 0.062 13.7 0.2 0.1 13.0 0.1 1.3 1 0 0 1 1 1 0 Membrane-integrating protein Mistic ABC_membrane PF00664.18 KII68208.1 - 2.4e-24 86.2 19.8 2.4e-24 86.2 13.7 1.5 2 0 0 2 2 2 1 ABC transporter transmembrane region SH3_2 PF07653.12 KII68208.1 - 0.012 15.0 0.0 0.035 13.5 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain ABC_tran PF00005.22 KII68210.1 - 2.5e-52 176.8 0.2 1e-29 103.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 KII68210.1 - 4.5e-40 137.8 60.0 2.8e-20 72.8 18.7 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.1 KII68210.1 - 1.4e-10 41.6 14.5 0.0063 16.5 1.6 5.6 3 2 1 4 4 4 3 AAA domain SMC_N PF02463.14 KII68210.1 - 3.6e-10 39.4 6.8 0.016 14.4 0.1 4.3 3 1 1 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KII68210.1 - 2.2e-06 27.7 0.0 0.027 14.4 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 KII68210.1 - 8.2e-06 25.9 0.2 0.11 12.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KII68210.1 - 5.6e-05 23.5 0.1 0.029 14.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 KII68210.1 - 6e-05 23.5 0.0 0.096 13.1 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein NACHT PF05729.7 KII68210.1 - 6.9e-05 22.5 0.1 0.028 14.0 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.1 KII68210.1 - 0.00021 20.7 0.0 0.44 9.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 KII68210.1 - 0.00021 20.7 1.1 0.34 10.4 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 KII68210.1 - 0.00036 20.0 0.1 0.41 10.0 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 KII68210.1 - 0.0004 20.3 0.1 0.21 11.5 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase MobB PF03205.9 KII68210.1 - 0.00098 18.8 0.7 1.1 8.9 0.0 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_15 PF13175.1 KII68210.1 - 0.0015 17.6 0.9 0.0015 17.6 0.6 3.2 3 1 0 3 3 3 1 AAA ATPase domain DUF258 PF03193.11 KII68210.1 - 0.0031 16.7 0.2 1.8 7.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_ATPase PF09818.4 KII68210.1 - 0.004 15.7 1.3 0.083 11.4 0.1 2.3 2 0 0 2 2 2 1 Predicted ATPase of the ABC class T2SE PF00437.15 KII68210.1 - 0.0052 15.7 0.0 0.89 8.3 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein Arch_ATPase PF01637.13 KII68210.1 - 0.0089 15.7 0.5 1 9.0 0.0 2.8 2 1 0 2 2 2 1 Archaeal ATPase DUF87 PF01935.12 KII68210.1 - 0.011 15.6 0.7 0.24 11.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF87 NB-ARC PF00931.17 KII68210.1 - 0.013 14.4 0.0 4.2 6.1 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.14 KII68210.1 - 0.013 14.9 1.1 1 8.7 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SbcCD_C PF13558.1 KII68210.1 - 0.018 14.9 0.3 14 5.7 0.1 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Viral_helicase1 PF01443.13 KII68210.1 - 0.018 14.5 0.1 2.3 7.6 0.0 2.7 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase SH3_2 PF07653.12 KII68210.1 - 0.026 14.0 0.0 0.059 12.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Zeta_toxin PF06414.7 KII68210.1 - 0.026 13.5 0.1 5 6.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_10 PF12846.2 KII68210.1 - 0.029 13.8 0.8 2.9 7.2 0.0 2.7 3 0 0 3 3 3 0 AAA-like domain AAA_30 PF13604.1 KII68210.1 - 0.036 13.6 0.0 16 4.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.4 KII68210.1 - 0.049 12.2 0.3 6.1 5.3 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_5 PF07728.9 KII68210.1 - 0.054 13.2 0.2 6.5 6.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KII68210.1 - 0.058 14.2 0.0 11 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain KH_2 PF07650.12 KII68210.1 - 0.059 12.9 0.1 6 6.4 0.0 2.6 2 0 0 2 2 2 0 KH domain AAA_18 PF13238.1 KII68210.1 - 0.096 12.9 0.0 23 5.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 KII68210.1 - 0.097 11.6 0.0 2.3 7.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATP-synt_ab PF00006.20 KII68210.1 - 0.1 12.1 0.0 16 4.9 0.0 2.6 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain SH3_1 PF00018.23 KII68210.1 - 0.13 11.6 0.1 0.43 10.0 0.0 1.9 2 0 0 2 2 1 0 SH3 domain AAA_33 PF13671.1 KII68210.1 - 0.27 11.1 0.0 6.2 6.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain WD40 PF00400.27 KII68211.1 - 2.5e-06 27.1 0.1 1.3 8.9 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat Integrin_beta PF00362.13 KII68215.1 - 5.6e-48 163.8 1.0 6.7e-28 97.7 0.0 2.5 1 1 1 2 2 2 2 Integrin, beta chain DDE_3 PF13358.1 KII68215.1 - 1.9e-09 37.4 0.0 3.2e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease PSI PF01437.20 KII68215.1 - 0.013 15.6 5.2 0.03 14.4 3.6 1.6 1 0 0 1 1 1 0 Plexin repeat Integrin_B_tail PF07965.7 KII68216.1 - 0.075 13.4 2.9 0.12 12.8 2.0 1.3 1 0 0 1 1 1 0 Integrin beta tail domain DDE_3 PF13358.1 KII68217.1 - 3.3e-08 33.4 0.0 3.8e-08 33.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII68218.1 - 2e-32 111.9 0.0 2.5e-32 111.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII68218.1 - 1.2e-06 28.5 0.0 1.6e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain GxGYxYP PF14323.1 KII68218.1 - 0.06 12.0 0.1 0.072 11.7 0.0 1.1 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function Abhydrolase_6 PF12697.2 KII68219.1 - 4.2e-26 92.2 0.0 7e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII68219.1 - 4e-20 72.3 0.0 2.3e-18 66.6 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KII68219.1 - 9.6e-13 48.1 0.0 3.7e-12 46.2 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KII68219.1 - 0.00032 20.4 0.0 0.0012 18.7 0.0 1.9 2 0 0 2 2 2 1 Putative lysophospholipase PAF-AH_p_II PF03403.8 KII68219.1 - 0.00036 18.9 0.0 0.0018 16.6 0.0 1.8 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Ndr PF03096.9 KII68219.1 - 0.00038 19.0 0.0 0.0013 17.3 0.0 1.8 2 0 0 2 2 2 1 Ndr family DUF676 PF05057.9 KII68219.1 - 0.045 13.0 0.0 0.28 10.4 0.0 2.2 2 0 0 2 2 2 0 Putative serine esterase (DUF676) DUF915 PF06028.6 KII68219.1 - 0.045 12.8 0.1 0.08 12.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Ser_hydrolase PF06821.8 KII68219.1 - 0.05 13.1 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Esterase PF00756.15 KII68219.1 - 0.053 12.9 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Lipase_3 PF01764.20 KII68219.1 - 0.1 12.2 0.0 0.23 11.0 0.0 1.6 2 0 0 2 2 2 0 Lipase (class 3) Thioesterase PF00975.15 KII68219.1 - 0.1 12.7 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.8 KII68219.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Fucokinase PF07959.7 KII68220.1 - 0.033 12.7 0.0 0.041 12.4 0.0 1.1 1 0 0 1 1 1 0 L-fucokinase Transglut_core PF01841.14 KII68221.1 - 1.3e-07 31.8 0.0 1.7e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_N PF00868.15 KII68222.1 - 4.3e-11 42.8 0.1 6.8e-11 42.2 0.1 1.3 1 0 0 1 1 1 1 Transglutaminase family DUF2187 PF09953.4 KII68222.1 - 0.053 13.2 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2187) Rax2 PF12768.2 KII68223.1 - 0.2 10.8 5.7 0.23 10.6 0.1 2.1 1 1 1 2 2 2 0 Cortical protein marker for cell polarity RAP1 PF07218.6 KII68223.1 - 0.48 8.4 17.1 0.57 8.2 11.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Tetraspannin PF00335.15 KII68223.1 - 0.66 9.2 2.1 0.74 9.0 1.4 1.1 1 0 0 1 1 1 0 Tetraspanin family Macoilin PF09726.4 KII68223.1 - 3.1 5.9 11.9 3.7 5.7 8.2 1.0 1 0 0 1 1 1 0 Transmembrane protein zf-CHCC PF10276.4 KII68224.1 - 2.4e-15 56.0 2.3 3.4e-15 55.5 1.6 1.3 1 0 0 1 1 1 1 Zinc-finger domain COX5B PF01215.14 KII68224.1 - 0.062 12.9 0.0 0.075 12.6 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb Rpr2 PF04032.11 KII68224.1 - 0.088 12.6 0.2 0.72 9.7 0.0 2.1 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-ribbon_3 PF13248.1 KII68224.1 - 0.096 11.9 0.2 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 zinc-ribbon domain adh_short PF00106.20 KII68228.1 - 2.9e-16 59.8 0.0 3.5e-16 59.5 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KII68228.1 - 1.5e-08 34.7 0.0 1.8e-08 34.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KII68228.1 - 2.8e-07 30.3 0.0 3.3e-07 30.1 0.0 1.0 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KII68228.1 - 0.0031 17.5 0.0 0.0038 17.2 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding TusA PF01206.12 KII68228.1 - 0.037 13.6 0.0 0.29 10.7 0.0 2.2 2 1 1 3 3 3 0 Sulfurtransferase TusA Epimerase PF01370.16 KII68228.1 - 0.042 13.2 0.0 0.046 13.1 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NmrA PF05368.8 KII68228.1 - 0.049 12.8 0.0 0.058 12.6 0.0 1.1 1 0 0 1 1 1 0 NmrA-like family THF_DHG_CYH_C PF02882.14 KII68228.1 - 0.068 12.2 0.0 0.099 11.7 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.13 KII68228.1 - 0.081 12.5 0.0 0.081 12.5 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.16 KII68228.1 - 0.15 11.9 1.2 0.16 11.8 0.8 1.3 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain HTH_28 PF13518.1 KII68229.1 - 7.1e-06 25.9 1.2 0.0042 17.0 0.1 2.3 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_33 PF13592.1 KII68229.1 - 6.3e-05 22.4 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII68229.1 - 8e-05 22.1 0.4 0.3 10.8 0.1 2.4 2 0 0 2 2 2 2 Homeodomain-like domain CENP-B_N PF04218.8 KII68229.1 - 0.00017 20.9 0.3 0.026 13.9 0.0 2.7 3 0 0 3 3 3 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc3_2 PF01498.13 KII68229.1 - 0.0007 19.6 0.2 0.0033 17.4 0.0 2.0 2 0 0 2 2 2 1 Transposase HTH_29 PF13551.1 KII68229.1 - 0.033 14.3 0.1 0.83 9.8 0.0 2.1 1 1 1 2 2 2 0 Winged helix-turn helix Pico_P2B PF01552.12 KII68229.1 - 0.061 13.4 0.4 0.12 12.5 0.0 1.7 2 0 0 2 2 2 0 Picornavirus 2B protein HTH_Tnp_IS630 PF01710.11 KII68229.1 - 0.28 10.8 1.3 3.4 7.3 0.1 2.1 1 1 1 2 2 2 0 Transposase DDE_3 PF13358.1 KII68230.1 - 0.00018 21.3 0.0 0.00035 20.3 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease COPI_assoc PF08507.5 KII68230.1 - 0.0081 15.8 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 COPI associated protein AvrPtoB-E3_ubiq PF09046.5 KII68231.1 - 0.14 12.1 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 AvrPtoB E3 ubiquitin ligase Annexin PF00191.15 KII68235.1 - 2.7e-08 33.5 0.0 0.0028 17.4 0.0 3.4 3 1 1 4 4 4 3 Annexin DDE_Tnp_IS1595 PF12762.2 KII68236.1 - 5.7e-08 32.7 0.2 5e-07 29.6 0.2 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain zf-H2C2_2 PF13465.1 KII68237.1 - 1.1e-24 85.4 41.2 4.1e-10 39.4 1.3 6.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.21 KII68237.1 - 1.4e-16 59.6 46.5 2.1e-06 27.7 3.0 5.7 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII68237.1 - 2.3e-16 58.8 40.1 7.4e-05 22.8 1.5 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII68237.1 - 3e-11 43.1 27.2 0.006 16.6 0.8 5.4 5 0 0 5 5 5 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 KII68237.1 - 2.2e-07 30.5 32.9 0.0012 18.6 0.7 5.4 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2HC_2 PF13913.1 KII68237.1 - 5.1e-06 26.0 21.0 0.03 13.9 0.6 5.1 5 0 0 5 5 5 3 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.2 KII68237.1 - 0.00028 20.9 28.1 0.62 10.2 1.4 5.2 1 1 4 5 5 5 3 C2H2 type zinc-finger (2 copies) zf-BED PF02892.10 KII68237.1 - 0.00098 18.8 23.0 0.76 9.5 2.5 4.7 2 1 3 5 5 5 3 BED zinc finger zf-met PF12874.2 KII68237.1 - 0.15 12.3 32.2 0.21 11.8 2.0 5.1 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-Di19 PF05605.7 KII68237.1 - 0.19 11.8 29.3 2.2 8.4 0.1 4.5 2 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Yippee-Mis18 PF03226.9 KII68237.1 - 1.1 9.4 9.3 0.97 9.5 0.8 2.8 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Rep_fac-A_C PF08646.5 KII68237.1 - 2.6 7.7 14.8 3.8 7.1 4.4 3.5 1 1 2 3 3 3 0 Replication factor-A C terminal domain LIM PF00412.17 KII68237.1 - 6 7.0 19.6 2.9 8.0 4.5 3.6 2 1 1 3 3 3 0 LIM domain C1_4 PF07975.7 KII68237.1 - 9.8 6.2 24.2 3.4 7.7 3.0 4.4 1 1 4 5 5 5 0 TFIIH C1-like domain DUF4211 PF13926.1 KII68238.1 - 0.033 13.5 0.6 0.25 10.7 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4211) DOCK-C2 PF14429.1 KII68239.1 - 0.0023 17.6 0.1 0.0032 17.1 0.0 1.2 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF2644 PF10841.3 KII68239.1 - 0.071 13.1 0.1 0.47 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2644) DUF2105 PF09878.4 KII68239.1 - 0.11 11.9 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2105) Ded_cyto PF06920.8 KII68240.1 - 5e-12 45.4 3.3 6.2e-12 45.1 2.3 1.1 1 0 0 1 1 1 1 Dedicator of cytokinesis Thg1C PF14413.1 KII68240.1 - 0.03 13.9 3.0 0.065 12.9 1.9 1.7 1 1 0 1 1 1 0 Thg1 C terminal domain DUF1301 PF06979.7 KII68240.1 - 0.056 13.5 0.1 0.098 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1301) DUF2465 PF10239.4 KII68240.1 - 0.25 10.5 2.2 0.29 10.3 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) Tetraspannin PF00335.15 KII68241.1 - 5.6e-17 61.7 2.2 7.3e-17 61.3 1.6 1.0 1 0 0 1 1 1 1 Tetraspanin family DsbB PF02600.11 KII68241.1 - 0.021 14.6 0.1 0.021 14.6 0.1 1.6 2 0 0 2 2 2 0 Disulfide bond formation protein DsbB DUF998 PF06197.8 KII68241.1 - 0.034 13.4 0.8 0.034 13.4 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF998) DUF2207 PF09972.4 KII68241.1 - 0.051 12.1 2.3 0.15 10.5 0.5 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) MARVEL PF01284.18 KII68241.1 - 0.072 12.9 2.4 0.15 11.8 0.4 2.3 2 1 0 2 2 2 0 Membrane-associating domain DUF2839 PF10999.3 KII68241.1 - 0.5 10.4 1.8 0.68 10.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) NAD_Gly3P_dh_C PF07479.9 KII68242.1 - 6.4e-20 71.3 0.0 6.6e-20 71.3 0.0 1.0 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus YibE_F PF07907.6 KII68245.1 - 0.082 12.0 11.7 0.11 11.6 8.1 1.2 1 0 0 1 1 1 0 YibE/F-like protein DUF4293 PF14126.1 KII68245.1 - 0.099 12.5 7.6 0.13 12.1 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) Bac_export_2 PF01312.14 KII68245.1 - 0.25 10.1 5.6 0.3 9.9 3.9 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family LMF1 PF06762.9 KII68245.1 - 1.4 7.6 7.6 1.7 7.3 5.3 1.1 1 0 0 1 1 1 0 Lipase maturation factor DUF1772 PF08592.6 KII68245.1 - 5.2 6.7 8.4 2.2 8.0 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) GSH_synth_ATP PF03917.12 KII68246.1 - 2.1e-102 342.4 0.1 2.6e-102 342.1 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 KII68246.1 - 7.9e-24 83.7 0.2 1.3e-22 79.8 0.0 2.7 2 1 0 2 2 2 1 Eukaryotic glutathione synthase DDE_3 PF13358.1 KII68247.1 - 7.8e-10 38.6 0.1 1.2e-09 38.0 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DEAD PF00270.24 KII68248.1 - 1e-43 148.7 0.1 1.7e-43 148.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII68248.1 - 1.1e-22 79.6 0.0 3e-22 78.2 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 KII68248.1 - 7.5e-19 67.0 0.0 1.5e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 KII68248.1 - 2e-05 24.5 0.2 3.6e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KII68248.1 - 0.0039 16.0 0.0 0.0064 15.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain PhoH PF02562.11 KII68248.1 - 0.085 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein zf-RING_2 PF13639.1 KII68249.1 - 2.2e-13 49.7 7.5 2.2e-13 49.7 5.2 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 KII68249.1 - 4e-09 36.3 6.4 4e-09 36.3 4.5 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KII68249.1 - 6.4e-09 35.3 4.0 6.4e-09 35.3 2.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII68249.1 - 1.2e-07 31.2 6.3 1.2e-07 31.2 4.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KII68249.1 - 3.5e-07 30.2 8.2 3.5e-07 30.2 5.7 2.5 2 1 0 2 2 2 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 KII68249.1 - 8.5e-06 25.3 5.1 8.5e-06 25.3 3.5 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.1 KII68249.1 - 4.7e-05 23.0 6.4 4.7e-05 23.0 4.4 1.8 2 0 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.1 KII68249.1 - 0.0017 17.8 3.1 0.0045 16.5 2.1 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.1 KII68249.1 - 0.18 11.7 10.4 0.047 13.5 3.6 2.6 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.3 KII68249.1 - 0.77 9.7 6.6 0.13 12.2 1.1 2.3 2 0 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.2 KII68249.1 - 1.1 9.3 11.2 0.32 11.0 4.7 2.2 2 0 0 2 2 2 0 RING-variant domain zf-Apc11 PF12861.2 KII68249.1 - 2.9 7.7 11.9 0.046 13.5 2.9 2.0 2 1 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger MOR2-PAG1_C PF14225.1 KII68251.1 - 0.47 10.1 6.3 2.2 7.9 0.1 2.4 3 0 0 3 3 3 0 Cell morphogenesis C-terminal Ribosomal_L13 PF00572.13 KII68252.1 - 2.1e-36 124.8 0.0 2.5e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Rhodanese PF00581.15 KII68254.1 - 1.5e-12 47.8 0.0 2.1e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_11 PF08241.7 KII68255.1 - 3.8e-19 68.9 0.0 6e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KII68255.1 - 9.3e-18 64.4 0.0 1.5e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII68255.1 - 3.1e-17 62.5 0.0 4.3e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KII68255.1 - 1.1e-14 54.7 0.0 1.7e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KII68255.1 - 3.1e-14 53.4 0.0 4.6e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KII68255.1 - 1.9e-10 40.2 0.0 2.8e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.8 KII68255.1 - 2.1e-08 33.6 0.2 3.8e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 KII68255.1 - 3e-08 33.6 0.0 5.8e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KII68255.1 - 3.4e-08 33.7 0.0 6.4e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 KII68255.1 - 1.7e-07 30.8 0.0 2.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.13 KII68255.1 - 4.9e-07 29.0 0.0 6.2e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.9 KII68255.1 - 1.8e-06 27.2 0.1 2.8e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.9 KII68255.1 - 2.5e-06 26.9 0.0 3.7e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 KII68255.1 - 7.2e-05 22.4 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 KII68255.1 - 9.9e-05 21.8 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_9 PF08003.6 KII68255.1 - 0.00041 19.1 0.0 0.00057 18.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.7 KII68255.1 - 0.00057 19.3 0.1 0.0015 17.9 0.1 1.6 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.14 KII68255.1 - 0.0016 18.0 0.0 0.003 17.1 0.0 1.4 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 KII68255.1 - 0.0055 15.7 0.0 0.015 14.3 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_15 PF09445.5 KII68255.1 - 0.0092 15.5 0.1 0.015 14.8 0.1 1.5 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.15 KII68255.1 - 0.016 14.2 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase AdoMet_MTase PF07757.8 KII68255.1 - 0.027 14.5 0.0 0.057 13.5 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TPMT PF05724.6 KII68255.1 - 0.029 13.7 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) UPF0020 PF01170.13 KII68255.1 - 0.052 13.1 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 GidB PF02527.10 KII68255.1 - 0.13 11.3 0.1 0.25 10.4 0.1 1.4 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G TAFII55_N PF04658.8 KII68256.1 - 4.3e-46 156.3 0.1 5.5e-46 156.0 0.1 1.1 1 0 0 1 1 1 1 TAFII55 protein conserved region gag-asp_proteas PF13975.1 KII68257.1 - 4.4e-05 23.2 0.0 7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII68257.1 - 0.00018 21.3 0.0 0.00053 19.8 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.6 KII68257.1 - 0.013 15.4 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease PF09668.5 KII68257.1 - 0.014 14.9 0.1 0.029 13.9 0.1 1.5 1 1 0 1 1 1 0 Aspartyl protease Asp_protease_2 PF13650.1 KII68257.1 - 0.024 15.1 0.0 0.04 14.4 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease EGF_2 PF07974.8 KII68258.1 - 0.27 11.4 25.4 0.058 13.5 3.9 3.0 2 0 0 2 2 2 0 EGF-like domain DUF572 PF04502.8 KII68259.1 - 1.9e-47 162.1 5.6 2.1e-47 161.9 3.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) ZZ PF00569.12 KII68259.1 - 0.019 14.5 1.3 0.94 9.0 0.1 2.2 2 0 0 2 2 2 0 Zinc finger, ZZ type DUF951 PF06107.6 KII68259.1 - 0.07 12.6 1.5 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) C1_4 PF07975.7 KII68259.1 - 0.081 12.9 0.6 0.14 12.1 0.4 1.4 1 0 0 1 1 1 0 TFIIH C1-like domain zf-RING_3 PF14369.1 KII68259.1 - 0.086 12.8 2.4 2.3 8.2 0.2 2.3 2 0 0 2 2 2 0 zinc-finger Esterase_phd PF10503.4 KII68259.1 - 0.1 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Esterase PHB depolymerase DUF572 PF04502.8 KII68260.1 - 8.2e-11 41.6 6.2 8.7e-11 41.6 4.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF4163 PF13739.1 KII68260.1 - 1.3 9.8 4.2 0.86 10.4 1.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4163) Pkinase PF00069.20 KII68262.1 - 2.5e-19 69.4 0.0 2.9e-19 69.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII68262.1 - 2e-13 50.0 0.0 2.4e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KII68263.1 - 2.8e-21 75.8 0.0 4.3e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PBD PF00786.23 KII68263.1 - 1.2e-14 54.4 1.0 5.7e-14 52.2 0.0 2.4 2 0 0 2 2 2 1 P21-Rho-binding domain Pkinase_Tyr PF07714.12 KII68263.1 - 2.8e-14 52.8 0.0 4.2e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RabGAP-TBC PF00566.13 KII68264.1 - 2.7e-10 40.1 1.6 2.1e-08 33.9 0.0 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain TSP_1 PF00090.14 KII68265.1 - 7.9e-09 35.5 1.6 7.9e-09 35.5 1.1 2.0 2 0 0 2 2 2 1 Thrombospondin type 1 domain Laminin_G_3 PF13385.1 KII68266.1 - 9.9e-15 55.1 0.1 1.3e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.12 KII68266.1 - 0.0017 17.8 0.0 0.0022 17.4 0.0 1.1 1 0 0 1 1 1 1 Pentaxin family Cpn60_TCP1 PF00118.19 KII68267.1 - 3.7e-145 484.2 0.5 4.6e-145 483.9 0.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PROCN PF08083.6 KII68270.1 - 6.1e-105 351.0 2.7 1e-104 350.3 1.9 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRO8NT PF08082.6 KII68270.1 - 4.6e-78 260.1 2.5 7.3e-78 259.4 1.7 1.3 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain DDE_Tnp_IS1595 PF12762.2 KII68271.1 - 8.3e-05 22.4 0.0 0.00011 22.0 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DnaJ PF00226.26 KII68272.1 - 4.6e-16 58.2 0.1 1.4e-15 56.7 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain BNR PF02012.15 KII68273.1 - 0.12 12.2 0.2 0.4 10.6 0.0 2.1 2 0 0 2 2 2 0 BNR/Asp-box repeat zf-UBR PF02207.15 KII68275.1 - 5.5e-17 61.2 11.1 1.4e-16 59.9 7.7 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Peptidase_M1 PF01433.15 KII68283.1 - 2.4e-59 201.3 9.7 9e-43 146.8 2.6 3.2 2 1 1 3 3 3 2 Peptidase family M1 ERAP1_C PF11838.3 KII68283.1 - 2.3e-31 109.2 0.0 3.5e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 KII68283.1 - 6.5e-13 48.8 0.1 1.3e-12 47.8 0.1 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily IstB_IS21_ATP PF08483.6 KII68283.1 - 0.0019 17.8 0.9 0.0047 16.5 0.6 1.6 1 0 0 1 1 1 1 IstB-like ATP binding N-terminal DUF1336 PF07059.7 KII68283.1 - 0.012 15.0 1.7 0.34 10.2 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1336) RVP PF00077.15 KII68284.1 - 1.1e-05 25.2 0.0 2.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII68284.1 - 3.9e-05 24.0 0.0 0.00014 22.3 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KII68284.1 - 5.5e-05 22.9 0.0 0.00012 21.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII68284.1 - 0.00014 21.6 0.9 0.00014 21.6 0.6 2.8 2 1 0 2 2 2 1 Zinc knuckle Asp_protease PF09668.5 KII68284.1 - 0.014 14.9 0.0 0.049 13.2 0.0 1.9 1 1 0 1 1 1 0 Aspartyl protease Arf PF00025.16 KII68285.1 - 6.7e-42 142.6 0.1 8e-42 142.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KII68285.1 - 1.2e-16 60.5 0.0 1.4e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII68285.1 - 2.2e-10 41.0 0.0 7.5e-10 39.3 0.0 1.7 2 0 0 2 2 2 1 Miro-like protein SRPRB PF09439.5 KII68285.1 - 3.8e-10 39.2 0.0 4.5e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 KII68285.1 - 8.5e-09 34.5 1.0 6.6e-07 28.3 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 KII68285.1 - 7.9e-07 28.4 0.0 1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KII68285.1 - 1.1e-05 25.3 0.0 2.6e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KII68285.1 - 3e-05 23.5 0.0 4.8e-05 22.8 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.12 KII68285.1 - 0.0064 16.0 0.1 1.6 8.2 0.0 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein TPP_enzyme_N PF02776.13 KII68285.1 - 0.016 14.7 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Dynamin_N PF00350.18 KII68285.1 - 0.018 14.8 0.1 0.048 13.4 0.1 1.6 1 1 0 2 2 2 0 Dynamin family AAA_33 PF13671.1 KII68285.1 - 0.039 13.8 0.1 0.16 11.8 0.0 1.8 1 1 0 2 2 2 0 AAA domain MobB PF03205.9 KII68285.1 - 0.065 12.9 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Bax1-I PF01027.15 KII68287.1 - 4.4e-20 72.1 30.1 1.5e-19 70.4 20.9 1.7 1 1 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF3754 PF12576.3 KII68287.1 - 8.2 6.0 8.7 7.4 6.2 4.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3754) Cyclin_N PF00134.18 KII68288.1 - 1.1e-17 63.7 0.5 9.1e-16 57.5 0.1 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 KII68288.1 - 0.013 15.4 1.2 0.067 13.1 0.1 2.5 1 1 1 2 2 2 0 Cyclin, C-terminal domain DUF3806 PF12713.2 KII68288.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3806) FlaC_arch PF05377.6 KII68288.1 - 0.11 12.3 0.3 0.76 9.7 0.0 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Adaptin_N PF01602.15 KII68289.1 - 7.6e-23 80.6 0.1 9.7e-23 80.2 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Adaptin_N PF01602.15 KII68290.1 - 1.8e-10 39.7 0.6 1.9e-10 39.7 0.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region tRNA_bind_2 PF13725.1 KII68290.1 - 0.031 14.3 1.5 0.047 13.7 0.8 1.5 1 1 1 2 2 2 0 Possible tRNA binding domain DUF3802 PF12290.3 KII68290.1 - 0.038 14.2 0.4 0.045 14.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) IBV_3A PF03617.8 KII68290.1 - 1.2 8.9 5.8 3.1 7.6 3.8 1.9 1 1 0 1 1 1 0 IBV 3A protein RNA_pol_3_Rpc31 PF11705.3 KII68291.1 - 0.0068 16.3 0.3 0.0076 16.2 0.2 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Ran_BP1 PF00638.13 KII68292.1 - 7.7e-09 35.6 0.0 1.5e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 RanBP1 domain DDE_3 PF13358.1 KII68294.1 - 4.6e-16 58.8 0.0 6.8e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII68294.1 - 0.00068 19.6 0.2 0.0011 18.9 0.1 1.4 1 0 0 1 1 1 1 Transposase DUF1662 PF07878.6 KII68294.1 - 0.092 12.5 0.3 0.092 12.5 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1662) FH2 PF02181.18 KII68295.1 - 3.9e-83 279.3 15.7 3.9e-83 279.3 10.9 3.8 4 0 0 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.11 KII68295.1 - 1.3e-30 106.2 0.2 1.3e-30 106.2 0.1 4.0 5 0 0 5 5 5 1 Diaphanous FH3 Domain Drf_GBD PF06371.8 KII68295.1 - 8.6e-18 64.3 2.6 8.6e-18 64.3 1.8 3.3 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain Picorna_P3A PF06363.6 KII68295.1 - 0.0034 17.3 0.1 0.041 13.8 0.2 2.8 2 0 0 2 2 2 1 Picornaviridae P3A protein NPV_P10 PF05531.7 KII68295.1 - 0.15 12.3 8.7 0.99 9.7 3.5 3.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Coatomer_WDAD PF04053.9 KII68296.1 - 3e-82 276.7 4.2 5.9e-82 275.8 2.9 1.5 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 KII68296.1 - 7.9e-76 255.2 0.0 1.3e-75 254.6 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 KII68296.1 - 6.6e-52 171.6 19.6 3.1e-10 39.5 0.3 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat TPR_1 PF00515.23 KII68296.1 - 0.016 14.8 1.5 0.15 11.6 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII68296.1 - 0.024 14.5 1.9 2 8.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 KII68296.1 - 0.062 13.2 0.2 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII68296.1 - 0.097 12.5 0.5 0.73 9.7 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Spt5-NGN PF03439.8 KII68297.1 - 9.7e-19 66.9 0.0 2.5e-18 65.6 0.0 1.8 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.24 KII68297.1 - 3.3e-08 32.9 38.5 0.00099 18.7 0.9 7.9 8 0 0 8 8 8 4 KOW motif Spt5_N PF11942.3 KII68297.1 - 2.5e-05 24.8 20.8 2.5e-05 24.8 14.4 2.1 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal FYVE PF01363.16 KII68298.1 - 3.1e-08 33.4 13.3 5.6e-07 29.3 9.2 2.5 1 1 0 1 1 1 1 FYVE zinc finger PH PF00169.24 KII68298.1 - 4.7e-05 23.5 0.1 7.2e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_3 PF14593.1 KII68298.1 - 0.097 12.5 0.2 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 PH domain zf-SNAP50_C PF12251.3 KII68298.1 - 0.91 8.8 9.4 0.85 8.9 5.6 1.6 2 0 0 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal AAA_23 PF13476.1 KII68299.1 - 8.1e-15 55.6 22.0 8.1e-15 55.6 15.2 4.6 2 2 2 4 4 4 2 AAA domain SMC_N PF02463.14 KII68299.1 - 1.9e-11 43.6 0.2 1.9e-11 43.6 0.1 3.9 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KII68299.1 - 6.1e-08 32.9 2.5 6.1e-08 32.9 1.7 4.3 1 1 1 3 3 3 1 AAA domain AAA_13 PF13166.1 KII68299.1 - 0.003 16.0 76.5 0.0051 15.3 0.3 4.3 3 1 1 4 4 4 3 AAA domain AAA_29 PF13555.1 KII68299.1 - 0.0051 16.2 0.0 0.012 15.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.14 KII68300.1 - 4.7e-10 39.0 0.0 5.8e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 KII68300.1 - 0.039 13.8 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit GTP_EFTU_D3 PF03143.12 KII68307.1 - 1.8e-17 63.3 0.4 1.9e-15 56.7 0.1 2.6 2 1 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 KII68307.1 - 8.5e-16 57.8 0.6 2.4e-15 56.4 0.4 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.22 KII68307.1 - 1.9e-12 47.0 0.0 1.6e-11 43.9 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.1 KII68307.1 - 0.00074 19.1 0.6 0.002 17.7 0.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Clat_adaptor_s PF01217.15 KII68308.1 - 0.017 14.8 1.3 0.017 14.8 0.9 1.8 2 0 0 2 2 2 0 Clathrin adaptor complex small chain Adap_comp_sub PF00928.16 KII68309.1 - 5.3e-14 51.9 1.6 6.1e-14 51.7 1.1 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Colipase-like PF15083.1 KII68309.1 - 0.011 15.6 0.8 0.016 15.1 0.5 1.2 1 0 0 1 1 1 0 Colipase-like Ldl_recept_a PF00057.13 KII68311.1 - 5.9e-07 29.2 10.6 5.9e-07 29.2 7.3 3.7 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII68311.1 - 0.0095 15.6 0.3 0.47 10.4 0.0 2.8 2 0 0 2 2 2 1 BNR/Asp-box repeat Bac_luciferase PF00296.15 KII68311.1 - 0.36 9.8 0.0 0.53 9.3 0.0 1.2 1 0 0 1 1 1 0 Luciferase-like monooxygenase E1-E2_ATPase PF00122.15 KII68312.1 - 0.00054 19.0 1.7 0.0012 17.9 0.1 1.9 1 1 1 2 2 2 1 E1-E2 ATPase DUF4293 PF14126.1 KII68312.1 - 0.081 12.8 0.7 0.13 12.1 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4293) HAD PF12710.2 KII68313.1 - 1.7e-13 51.1 0.0 5e-13 49.6 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KII68313.1 - 2.2e-12 47.8 0.6 1.1e-10 42.3 0.4 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII68313.1 - 3.3e-12 46.1 0.0 1.3e-11 44.2 0.0 2.0 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KII68313.1 - 1.8e-05 24.4 0.3 0.00092 18.8 0.1 2.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase GFRP PF06399.8 KII68313.1 - 0.1 12.2 0.0 0.52 9.9 0.0 2.1 2 0 0 2 2 2 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) DUF1697 PF08002.6 KII68313.1 - 0.11 12.4 0.0 0.42 10.6 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1697) RhoGEF PF00621.15 KII68314.1 - 4.3e-08 33.2 2.1 5.6e-08 32.8 1.5 1.0 1 0 0 1 1 1 1 RhoGEF domain Flu_B_M2 PF04772.7 KII68314.1 - 0.068 13.2 0.1 0.079 13.0 0.0 1.2 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) E1-E2_ATPase PF00122.15 KII68315.1 - 1.6e-18 66.5 0.1 3.7e-18 65.3 0.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 KII68315.1 - 3.2e-16 60.0 0.0 1.1e-15 58.3 0.0 2.0 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KII68315.1 - 1.1e-14 55.4 0.2 1.3e-13 51.8 0.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII68315.1 - 3.3e-11 42.9 0.0 1e-10 41.4 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KII68315.1 - 0.00015 21.4 0.9 0.0023 17.5 0.2 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4014 PF13198.1 KII68315.1 - 1.3 9.4 6.7 4.7 7.6 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4014) RRP7 PF12923.2 KII68318.1 - 2.7e-10 40.3 10.7 9.7e-10 38.5 7.4 1.8 1 1 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) Leuk-A4-hydro_C PF09127.6 KII68319.1 - 0.01 15.4 1.2 0.015 14.8 0.8 1.3 1 0 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal VirE PF05272.6 KII68319.1 - 0.087 12.2 0.1 0.16 11.4 0.1 1.4 1 1 0 1 1 1 0 Virulence-associated protein E Antimicrobial19 PF08225.6 KII68319.1 - 0.73 9.2 3.1 5 6.6 0.2 2.3 2 0 0 2 2 2 0 Pseudin antimicrobial peptide Med10 PF09748.4 KII68320.1 - 5.9e-16 58.4 0.0 8.4e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex R3H-assoc PF13902.1 KII68321.1 - 0.00014 21.8 0.4 0.00032 20.6 0.0 1.7 1 1 1 2 2 2 1 R3H-associated N-terminal domain DUF1639 PF07797.9 KII68321.1 - 0.0061 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1639) DUF1368 PF07112.6 KII68321.1 - 0.049 12.2 0.2 0.051 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1368) PEN-2 PF10251.4 KII68322.1 - 2.3e-16 59.7 0.7 2.7e-16 59.5 0.5 1.0 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase zf-DHHC PF01529.15 KII68322.1 - 0.015 14.6 2.2 0.018 14.4 1.5 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase PSII PF00421.14 KII68322.1 - 0.044 12.3 0.2 0.052 12.1 0.2 1.0 1 0 0 1 1 1 0 Photosystem II protein DUF3099 PF11298.3 KII68322.1 - 0.052 13.3 0.8 0.23 11.2 0.2 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3099) OAD_gamma PF04277.8 KII68322.1 - 0.079 13.3 0.9 0.12 12.7 0.6 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Arf PF00025.16 KII68323.1 - 9.8e-51 171.4 0.1 1.2e-50 171.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KII68323.1 - 1.3e-08 34.3 0.0 1.7e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 KII68323.1 - 1.8e-08 33.4 6.0 4.4e-06 25.6 0.2 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 KII68323.1 - 7.8e-07 29.6 0.0 1.1e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 KII68323.1 - 6.5e-06 25.4 0.0 8.1e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KII68323.1 - 1.8e-05 24.6 0.0 2.4e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KII68323.1 - 3.7e-05 23.0 0.0 4.9e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 KII68323.1 - 0.044 13.6 0.1 0.58 9.9 0.1 2.1 2 0 0 2 2 2 0 Dynamin family PduV-EutP PF10662.4 KII68323.1 - 0.056 12.9 0.0 0.25 10.8 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CdhD PF03599.11 KII68323.1 - 0.15 10.4 0.0 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit DUF4561 PF15120.1 KII68324.1 - 0.0056 16.1 1.2 0.012 15.0 0.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4561) HTH_38 PF13936.1 KII68324.1 - 0.061 12.8 0.5 0.18 11.4 0.0 2.0 2 1 0 2 2 2 0 Helix-turn-helix domain Hormone_6 PF00236.13 KII68324.1 - 0.062 13.1 0.7 0.11 12.3 0.2 1.7 1 1 0 1 1 1 0 Glycoprotein hormone HTH_11 PF08279.7 KII68324.1 - 0.071 12.7 0.1 0.59 9.8 0.0 2.0 2 0 0 2 2 2 0 HTH domain KIAA1430 PF13879.1 KII68324.1 - 0.2 12.1 2.1 0.25 11.7 1.5 1.2 1 0 0 1 1 1 0 KIAA1430 homologue Adaptin_N PF01602.15 KII68325.1 - 1.8e-49 168.4 16.8 1.8e-49 168.4 11.6 2.4 2 1 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 KII68325.1 - 9.4e-39 132.0 1.4 9.4e-39 132.0 0.9 2.0 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 KII68325.1 - 3.3e-32 111.0 0.1 8.7e-32 109.7 0.1 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 KII68325.1 - 1.8e-07 31.3 0.0 0.29 11.4 0.1 4.5 2 2 2 4 4 4 2 HEAT repeats HEAT PF02985.17 KII68325.1 - 0.00016 21.4 0.4 0.068 13.2 0.0 4.5 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 KII68325.1 - 0.15 12.5 0.1 2.3 8.7 0.0 3.0 3 0 0 3 3 3 0 HEAT-like repeat Lumazine_bd PF12870.2 KII68326.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Lumazine-binding domain Fork_head PF00250.13 KII68327.1 - 1.9e-19 69.4 0.1 3.3e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Fork head domain Peptidase_A22B PF04258.8 KII68328.1 - 2.2e-57 194.7 13.6 3.1e-57 194.3 9.4 1.2 1 0 0 1 1 1 1 Signal peptide peptidase DUF1065 PF06358.6 KII68328.1 - 0.037 13.7 0.8 0.076 12.7 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1065) DUF3483 PF11982.3 KII68328.1 - 0.26 10.5 1.6 0.42 9.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3483) Metallophos PF00149.23 KII68329.1 - 1.4e-25 89.8 0.5 1.8e-25 89.5 0.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase rve PF00665.21 KII68330.1 - 2.2e-11 43.9 0.1 4.7e-10 39.6 0.0 2.2 1 1 1 2 2 2 2 Integrase core domain rve_3 PF13683.1 KII68330.1 - 0.0057 16.1 0.1 0.0089 15.5 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain RCC1 PF00415.13 KII68331.1 - 5.6e-44 148.1 9.6 4.9e-11 42.6 0.1 6.5 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KII68331.1 - 1.5e-21 75.4 34.1 8.9e-06 25.1 0.1 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat CBM_X PF06204.6 KII68331.1 - 0.13 11.8 1.3 39 3.8 0.0 3.8 5 0 0 5 5 5 0 Putative carbohydrate binding domain RRM_6 PF14259.1 KII68332.1 - 7.1e-12 45.1 1.4 1.1e-08 34.8 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII68332.1 - 1.4e-11 44.0 0.6 4.8e-09 35.9 0.1 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII68332.1 - 5.6e-07 29.0 2.0 0.0024 17.4 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.12 KII68332.1 - 2.6e-05 24.2 0.2 0.00011 22.2 0.0 2.2 2 0 0 2 2 2 1 PWI domain Nup35_RRM PF05172.8 KII68332.1 - 0.0061 16.2 0.3 1.2 8.9 0.0 2.8 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.1 KII68332.1 - 0.011 15.4 0.0 0.37 10.6 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.19 KII68332.1 - 0.27 10.9 3.3 0.61 9.8 2.3 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) EMP24_GP25L PF01105.19 KII68333.1 - 2.9e-11 43.4 1.4 3.9e-11 42.9 1.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SecD_SecF PF02355.11 KII68333.1 - 0.056 12.6 0.2 0.073 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein export membrane protein Histone PF00125.19 KII68334.1 - 1.9e-24 85.5 0.6 2.9e-24 84.9 0.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KII68334.1 - 5.1e-06 26.4 0.0 1.2e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 KII68334.1 - 0.0033 17.6 0.0 0.006 16.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Med7 PF05983.6 KII68335.1 - 3.9e-35 121.0 1.9 4.9e-35 120.6 1.3 1.2 1 0 0 1 1 1 1 MED7 protein DUF948 PF06103.6 KII68335.1 - 0.057 13.2 0.7 0.22 11.3 0.2 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TMF_DNA_bd PF12329.3 KII68335.1 - 0.058 13.2 0.3 0.058 13.2 0.2 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding PRANC PF09372.5 KII68335.1 - 0.093 12.7 2.5 0.11 12.4 0.6 2.0 2 1 0 2 2 2 0 PRANC domain Prefoldin PF02996.12 KII68335.1 - 0.12 12.0 2.5 0.28 10.8 1.7 1.6 1 0 0 1 1 1 0 Prefoldin subunit Sec8_exocyst PF04048.9 KII68335.1 - 0.15 11.6 3.9 0.67 9.5 1.3 2.3 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain CorA PF01544.13 KII68335.1 - 0.32 9.9 4.6 0.82 8.6 1.1 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein FlxA PF14282.1 KII68335.1 - 0.63 10.0 7.9 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 FlxA-like protein Polyketide_cyc PF03364.15 KII68336.1 - 3.5e-12 46.4 0.0 4.9e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport ATP-synt_ab PF00006.20 KII68337.1 - 6.2e-63 212.1 0.0 1e-62 211.4 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KII68337.1 - 1.7e-24 86.4 0.2 3.2e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KII68337.1 - 6.2e-22 77.5 1.9 1.3e-21 76.5 1.3 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Arch_ATPase PF01637.13 KII68337.1 - 0.0029 17.3 0.0 0.0055 16.4 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase MobB PF03205.9 KII68337.1 - 0.0095 15.6 0.2 2 8.0 0.0 3.0 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 KII68337.1 - 0.011 15.1 0.4 0.031 13.6 0.1 1.9 2 1 0 2 2 2 0 AAA domain KaiC PF06745.8 KII68337.1 - 0.019 14.0 0.1 0.031 13.3 0.1 1.4 1 0 0 1 1 1 0 KaiC NACHT PF05729.7 KII68337.1 - 0.025 14.2 0.1 0.09 12.4 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA PF00004.24 KII68337.1 - 0.037 14.2 0.1 1.1 9.5 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 KII68337.1 - 0.05 12.4 0.5 0.13 11.1 0.1 1.8 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.1 KII68337.1 - 0.053 13.4 0.0 0.15 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 KII68337.1 - 0.06 12.5 0.1 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 KII68337.1 - 0.071 13.2 0.0 0.32 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 KII68337.1 - 0.084 13.0 0.0 0.25 11.5 0.0 1.8 2 0 0 2 2 1 0 RNA helicase DUF2075 PF09848.4 KII68337.1 - 0.14 11.1 0.1 0.36 9.7 0.1 1.6 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) UBA_4 PF14555.1 KII68338.1 - 3e-09 36.2 0.3 4.9e-09 35.5 0.2 1.3 1 0 0 1 1 1 1 UBA-like domain Sigma70_r1_1 PF03979.9 KII68339.1 - 0.0042 16.9 0.3 0.05 13.5 0.3 2.2 2 0 0 2 2 2 1 Sigma-70 factor, region 1.1 KH_5 PF13184.1 KII68339.1 - 0.011 15.5 0.6 0.021 14.6 0.1 1.7 2 0 0 2 2 2 0 NusA-like KH domain UBX PF00789.15 KII68339.1 - 0.039 14.0 0.0 0.078 13.0 0.0 1.6 1 0 0 1 1 1 0 UBX domain PB1 PF00564.19 KII68339.1 - 0.061 12.9 0.6 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 PB1 domain Ubiquitin_2 PF14560.1 KII68339.1 - 0.084 13.1 2.3 0.13 12.5 0.2 2.4 2 1 0 2 2 2 0 Ubiquitin-like domain Peptidase_C97 PF05903.9 KII68344.1 - 3.8e-31 107.9 0.3 4.6e-31 107.6 0.2 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain PP1_inhibitor PF05361.7 KII68344.1 - 0.077 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor LRAT PF04970.8 KII68344.1 - 0.095 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase DnaB PF00772.16 KII68344.1 - 0.1 12.5 0.1 20 5.1 0.0 2.4 2 0 0 2 2 2 0 DnaB-like helicase N terminal domain DUF778 PF05608.7 KII68344.1 - 0.23 11.4 1.0 0.48 10.3 0.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF778) Sec1 PF00995.18 KII68345.1 - 4.5e-66 223.6 0.1 5.3e-66 223.4 0.1 1.0 1 0 0 1 1 1 1 Sec1 family DUF3741 PF12552.3 KII68345.1 - 0.34 10.6 2.6 0.27 10.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3741) Peptidase_M14 PF00246.19 KII68346.1 - 3.7e-44 151.4 0.7 4.6e-44 151.1 0.5 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.1 KII68346.1 - 6.3e-10 38.9 0.0 9.2e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF4480 PF13715.1 KII68346.1 - 0.0052 16.7 0.0 0.0084 16.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4480) Med23 PF11573.3 KII68348.1 - 5.7e-27 93.5 19.3 5.7e-27 93.5 13.4 1.4 2 0 0 2 2 2 1 Mediator complex subunit 23 TIP49 PF06068.8 KII68350.1 - 2e-169 563.5 1.1 2.3e-169 563.3 0.7 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 KII68350.1 - 5.4e-13 49.2 1.1 5.9e-08 32.9 0.0 2.9 2 1 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KII68350.1 - 2.4e-11 43.1 1.2 1.4e-06 27.5 0.0 2.8 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 KII68350.1 - 1.2e-08 35.1 0.0 0.0028 17.6 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 KII68350.1 - 3.3e-08 33.7 0.6 0.009 16.1 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.9 KII68350.1 - 2.8e-07 30.3 1.3 0.0028 17.4 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 KII68350.1 - 1.4e-06 27.6 0.0 0.00021 20.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KII68350.1 - 0.0001 21.9 0.1 0.00036 20.2 0.0 1.9 2 0 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 KII68350.1 - 0.00014 21.7 0.0 0.25 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 KII68350.1 - 0.0003 20.2 0.0 0.00082 18.8 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.1 KII68350.1 - 0.00049 20.9 0.0 0.0012 19.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 KII68350.1 - 0.0011 18.5 0.0 0.26 10.7 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Parvo_NS1 PF01057.12 KII68350.1 - 0.0015 17.4 0.0 0.0027 16.6 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_28 PF13521.1 KII68350.1 - 0.0017 18.3 0.0 0.0033 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII68350.1 - 0.002 18.4 0.1 0.0058 16.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.1 KII68350.1 - 0.0031 16.9 0.0 0.0061 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 KII68350.1 - 0.009 16.3 0.0 0.032 14.5 0.0 2.1 2 0 0 2 2 2 1 ABC transporter DnaB_C PF03796.10 KII68350.1 - 0.0093 14.8 0.1 0.027 13.3 0.0 1.7 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.7 KII68350.1 - 0.013 14.6 0.1 0.026 13.6 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.11 KII68350.1 - 0.016 14.4 0.3 0.04 13.1 0.0 1.7 2 0 0 2 2 1 0 PhoH-like protein DUF2075 PF09848.4 KII68350.1 - 0.018 14.0 0.0 0.034 13.1 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.1 KII68350.1 - 0.021 14.7 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 KII68350.1 - 0.024 14.4 0.3 0.29 10.9 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_11 PF13086.1 KII68350.1 - 0.033 13.7 0.1 0.1 12.1 0.0 1.8 2 1 0 2 2 2 0 AAA domain NACHT PF05729.7 KII68350.1 - 0.042 13.5 0.0 0.09 12.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain PIF1 PF05970.9 KII68350.1 - 0.047 12.6 0.1 4.7 6.0 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase Baculo_PEP_C PF04513.7 KII68350.1 - 0.063 13.1 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_30 PF13604.1 KII68350.1 - 0.084 12.4 0.1 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 KII68350.1 - 0.097 12.8 0.0 0.3 11.2 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Homeobox PF00046.24 KII68351.1 - 9.9e-20 69.9 0.6 1.7e-19 69.1 0.4 1.4 1 0 0 1 1 1 1 Homeobox domain Cytadhesin_P30 PF07271.6 KII68351.1 - 1.9 7.7 8.0 2.5 7.3 5.6 1.2 1 0 0 1 1 1 0 Cytadhesin P30/P32 Homeobox_KN PF05920.6 KII68351.1 - 9.4 6.0 6.4 1.5 8.5 0.1 2.6 3 0 0 3 3 3 0 Homeobox KN domain Como_SCP PF02248.11 KII68352.1 - 0.014 14.7 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 Small coat protein SH3_1 PF00018.23 KII68353.1 - 8.6e-57 188.3 2.1 9.3e-16 56.9 0.0 4.1 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.1 KII68353.1 - 2.4e-54 180.6 0.3 2.9e-13 49.1 0.0 4.1 4 0 0 4 4 4 4 Variant SH3 domain SH3_2 PF07653.12 KII68353.1 - 8.8e-40 133.9 0.0 2.7e-11 42.7 0.0 4.1 4 0 0 4 4 4 4 Variant SH3 domain hSH3 PF14603.1 KII68353.1 - 9e-05 22.4 0.0 0.21 11.6 0.0 3.1 2 1 1 3 3 3 2 Helically-extended SH3 domain SH3_3 PF08239.6 KII68353.1 - 0.00053 20.1 0.7 0.57 10.4 0.0 3.6 4 0 0 4 4 4 1 Bacterial SH3 domain Aldo_ket_red PF00248.16 KII68355.1 - 3.6e-33 114.5 0.0 4.1e-33 114.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family FYVE PF01363.16 KII68356.1 - 7.6e-11 41.7 19.2 3.5e-10 39.6 13.3 2.0 1 1 0 1 1 1 1 FYVE zinc finger PH PF00169.24 KII68356.1 - 0.01 16.0 0.2 0.02 15.0 0.1 1.6 1 1 0 1 1 1 0 PH domain GCV_H PF01597.14 KII68357.1 - 1.7e-34 118.0 0.4 3.5e-34 117.0 0.3 1.5 1 1 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 KII68357.1 - 0.0019 17.8 0.2 0.003 17.1 0.2 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme RSF PF14876.1 KII68357.1 - 0.056 12.2 0.0 0.067 11.9 0.0 1.1 1 0 0 1 1 1 0 Respiratory growth transcriptional regulator RnfC_N PF13375.1 KII68357.1 - 0.085 12.5 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain DUF2296 PF10058.4 KII68358.1 - 4.1e-09 36.0 0.0 7.7e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) Ion_trans PF00520.26 KII68358.1 - 0.071 12.3 0.0 0.078 12.2 0.0 1.1 1 0 0 1 1 1 0 Ion transport protein SNO PF01174.14 KII68361.1 - 0.026 14.1 0.1 0.032 13.8 0.1 1.2 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Orthopox_F6 PF06601.7 KII68361.1 - 0.37 10.7 3.3 5.7 6.9 0.1 2.3 2 1 0 2 2 2 0 Orthopoxvirus F6 protein AAA PF00004.24 KII68362.1 - 5.6e-29 101.0 0.0 1.2e-28 99.9 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KII68362.1 - 2.7e-05 23.3 0.0 5e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KII68362.1 - 0.0003 20.9 0.2 0.0066 16.5 0.0 2.4 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 KII68362.1 - 0.00039 20.1 0.2 0.02 14.5 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KII68362.1 - 0.0011 19.8 0.0 0.0023 18.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII68362.1 - 0.0044 16.7 0.1 0.021 14.5 0.0 2.1 2 1 0 2 2 2 1 Part of AAA domain IstB_IS21 PF01695.12 KII68362.1 - 0.013 14.9 0.0 0.029 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 KII68362.1 - 0.025 13.7 0.1 0.054 12.6 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KII68362.1 - 0.027 13.8 1.2 0.34 10.2 0.2 2.4 2 1 0 3 3 3 0 AAA domain SKI PF01202.17 KII68362.1 - 0.057 13.2 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate kinase KaiC PF06745.8 KII68362.1 - 0.095 11.8 0.4 1.6 7.7 0.1 2.2 1 1 1 2 2 2 0 KaiC AAA_18 PF13238.1 KII68362.1 - 0.096 12.9 0.1 0.29 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KII68362.1 - 0.11 11.9 0.1 0.93 8.9 0.0 2.3 2 1 1 3 3 3 0 Sigma-54 interaction domain AAA_16 PF13191.1 KII68362.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain PTR2 PF00854.16 KII68363.1 - 1.2e-05 24.2 0.4 3.6e-05 22.7 0.0 1.9 1 1 0 1 1 1 1 POT family DUF4397 PF14344.1 KII68363.1 - 0.11 12.7 0.0 0.4 11.0 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4397) Vac_Fusion PF02346.11 KII68364.1 - 0.061 12.7 2.2 0.28 10.6 0.4 2.7 2 0 0 2 2 2 0 Chordopoxvirus fusion protein PSP1 PF04468.7 KII68365.1 - 0.094 12.7 0.0 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 PSP1 C-terminal conserved region Adap_comp_sub PF00928.16 KII68366.1 - 3.6e-20 72.1 0.2 4.7e-20 71.7 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 KII68366.1 - 1.7e-05 24.5 0.6 0.00011 21.8 0.0 2.3 1 1 1 2 2 2 1 Clathrin adaptor complex small chain Serpin PF00079.15 KII68367.1 - 3.2e-47 161.4 4.8 3.6e-47 161.2 3.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) OPA3 PF07047.7 KII68368.1 - 1.8e-32 111.9 0.1 2.3e-32 111.6 0.1 1.1 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Glyco_transf_10 PF00852.14 KII68369.1 - 1.4e-42 145.4 7.5 1.7e-42 145.2 5.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) DUF1160 PF06648.6 KII68369.1 - 0.033 13.9 1.2 0.32 10.7 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1160) DUF2317 PF10079.4 KII68369.1 - 0.086 11.4 0.6 3.8 6.0 0.0 2.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2317) DUF1493 PF07377.7 KII68369.1 - 2.2 8.4 5.8 2.4 8.2 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1493) Glyco_transf_10 PF00852.14 KII68370.1 - 1.6e-42 145.3 1.5 1.8e-42 145.1 1.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) Folate_rec PF03024.9 KII68371.1 - 4e-33 114.4 24.3 5e-33 114.0 16.9 1.1 1 0 0 1 1 1 1 Folate receptor family Folate_rec PF03024.9 KII68372.1 - 3.7e-08 33.1 0.8 4.4e-08 32.9 0.6 1.0 1 0 0 1 1 1 1 Folate receptor family Folate_rec PF03024.9 KII68373.1 - 2.6e-31 108.5 17.6 2.9e-31 108.3 12.2 1.0 1 0 0 1 1 1 1 Folate receptor family Conotoxin PF02950.12 KII68373.1 - 0.12 13.2 0.2 0.12 13.2 0.1 2.7 2 1 0 2 2 2 0 Conotoxin AdoHcyase PF05221.12 KII68374.1 - 3.5e-21 75.3 0.0 3.5e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KII68374.1 - 6.1e-15 55.4 0.2 8.1e-15 55.0 0.2 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 KII68374.1 - 0.0028 16.8 0.1 0.0042 16.2 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UPF0180 PF03698.8 KII68374.1 - 0.056 13.2 0.1 0.093 12.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) IF2_N PF04760.10 KII68374.1 - 0.11 12.2 0.1 2.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region AdoHcyase PF05221.12 KII68375.1 - 2.2e-89 298.9 0.0 2.5e-89 298.7 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KII68375.1 - 1.5e-58 197.2 0.3 2.5e-58 196.4 0.2 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 KII68375.1 - 2.4e-10 39.8 0.0 4.2e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 KII68375.1 - 2.7e-05 23.5 0.1 4.1e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain THF_DHG_CYH_C PF02882.14 KII68375.1 - 0.00029 19.9 0.3 0.00092 18.3 0.2 1.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.1 KII68375.1 - 0.0039 17.4 0.3 0.021 15.0 0.1 2.1 2 0 0 2 2 2 1 Putative NAD(P)-binding ELFV_dehydrog PF00208.16 KII68375.1 - 0.013 15.0 0.1 0.024 14.2 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.13 KII68375.1 - 0.015 15.3 0.1 0.035 14.1 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain TAF4 PF05236.9 KII68376.1 - 0.00013 21.3 11.5 0.0014 17.9 8.0 2.4 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family DUF2937 PF11157.3 KII68376.1 - 0.033 13.5 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) Cytomega_UL84 PF06284.6 KII68378.1 - 0.041 12.3 3.0 2.2 6.5 0.1 2.1 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein DDE_Tnp_IS1595 PF12762.2 KII68379.1 - 2.7e-12 46.7 0.0 2.9e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Ribosomal_S4 PF00163.14 KII68381.1 - 4.7e-21 74.9 0.5 4.7e-21 74.9 0.3 1.8 3 0 0 3 3 3 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 KII68381.1 - 4.3e-11 42.0 0.5 1.1e-10 40.7 0.3 1.7 1 0 0 1 1 1 1 S4 domain Ras PF00071.17 KII68382.1 - 6.5e-65 217.4 3.3 7.5e-65 217.2 2.3 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII68382.1 - 2.8e-22 79.4 0.6 4.3e-22 78.8 0.4 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII68382.1 - 1.8e-18 66.4 0.6 2.2e-18 66.1 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KII68382.1 - 1.8e-08 33.8 0.9 2.5e-08 33.3 0.6 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KII68382.1 - 1.2e-05 24.8 1.6 2.1e-05 24.0 1.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KII68382.1 - 4.3e-05 23.4 0.4 6.2e-05 22.9 0.3 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KII68382.1 - 5.4e-05 22.4 0.3 7.1e-05 22.1 0.2 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.12 KII68382.1 - 0.00039 20.0 0.6 0.00062 19.3 0.1 1.5 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_15 PF13175.1 KII68382.1 - 0.0067 15.5 1.2 0.0082 15.2 0.9 1.1 1 0 0 1 1 1 1 AAA ATPase domain YTH PF04146.10 KII68382.1 - 0.016 14.7 0.4 0.021 14.4 0.3 1.2 1 0 0 1 1 1 0 YT521-B-like domain AAA_22 PF13401.1 KII68382.1 - 0.017 15.2 0.0 0.028 14.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 KII68382.1 - 0.023 14.9 0.2 0.042 14.1 0.1 1.6 1 1 0 1 1 1 0 ABC transporter DUF258 PF03193.11 KII68382.1 - 0.025 13.7 0.4 0.098 11.8 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 KII68382.1 - 0.047 13.2 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 KII68382.1 - 0.057 13.3 0.1 0.093 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 KII68382.1 - 0.11 12.4 0.3 0.18 11.6 0.2 1.5 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.15 KII68382.1 - 0.47 9.0 4.4 3.9 6.0 0.5 2.5 1 1 1 2 2 2 0 G-protein alpha subunit Rcd1 PF04078.8 KII68383.1 - 3.1e-13 49.1 1.3 3.7e-13 48.9 0.9 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Rcd1 PF04078.8 KII68384.1 - 1.3e-11 43.8 1.9 1.7e-11 43.4 1.3 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like ETAA1 PF15350.1 KII68384.1 - 0.017 13.2 0.3 0.017 13.1 0.2 1.1 1 0 0 1 1 1 0 Ewing's tumour-associated antigen 1 homologue DUF3294 PF07957.6 KII68384.1 - 0.082 12.4 1.3 0.17 11.3 0.8 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3294) RabGAP-TBC PF00566.13 KII68385.1 - 6e-27 94.5 0.1 7.8e-27 94.1 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Prp18 PF02840.10 KII68386.1 - 1.3e-40 138.5 2.1 6.1e-33 113.6 0.1 2.7 2 1 1 3 3 3 2 Prp18 domain APP_N PF02177.11 KII68386.1 - 0.027 14.3 0.2 0.085 12.7 0.0 1.9 2 1 0 2 2 2 0 Amyloid A4 N-terminal heparin-binding DAO PF01266.19 KII68386.1 - 0.052 12.4 0.1 3 6.6 0.0 2.0 1 1 1 2 2 2 0 FAD dependent oxidoreductase DUF4303 PF14136.1 KII68386.1 - 0.087 12.4 0.7 0.16 11.6 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4303) Sec20 PF03908.8 KII68386.1 - 0.12 12.0 0.3 0.47 10.1 0.2 2.1 1 1 0 1 1 1 0 Sec20 DUF816 PF05674.7 KII68386.1 - 0.13 11.9 2.3 0.17 11.6 0.8 1.7 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF816) Cation_ATPase_C PF00689.16 KII68387.1 - 0.12 11.9 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus PRP4 PF08799.6 KII68388.1 - 4.1e-08 32.3 0.0 6.2e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Flavodoxin_3 PF12641.2 KII68388.1 - 0.11 11.9 0.8 0.15 11.4 0.6 1.1 1 0 0 1 1 1 0 Flavodoxin domain Med30 PF11315.3 KII68388.1 - 0.15 12.1 2.8 0.18 11.9 2.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 30 DUF3513 PF12026.3 KII68388.1 - 0.21 11.1 2.9 0.25 10.8 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) NUC153 PF08159.7 KII68389.1 - 3e-08 33.0 2.7 7.4e-08 31.8 1.9 1.6 1 0 0 1 1 1 1 NUC153 domain PQQ_3 PF13570.1 KII68389.1 - 0.016 15.4 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 PQQ-like domain WD40 PF00400.27 KII68389.1 - 0.029 14.2 0.2 2.8 7.9 0.0 3.1 3 0 0 3 3 3 0 WD domain, G-beta repeat MBOAT PF03062.14 KII68392.1 - 2.8e-17 62.8 21.0 3.2e-17 62.6 14.6 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 KII68392.1 - 0.0039 17.2 0.7 0.0039 17.2 0.5 2.0 2 1 0 2 2 2 1 Membrane bound O-acyl transferase family DDE_1 PF03184.14 KII68393.1 - 0.0021 17.2 0.1 0.0035 16.5 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Ag332 PF04671.7 KII68398.1 - 0.79 9.5 5.0 0.59 9.9 1.6 2.0 2 0 0 2 2 2 0 Erythrocyte membrane-associated giant protein antigen 332 Annexin PF00191.15 KII68399.1 - 1.2e-14 53.9 1.7 0.0036 17.1 0.2 4.4 4 0 0 4 4 4 4 Annexin BNR PF02012.15 KII68401.1 - 0.0052 16.4 1.4 0.23 11.4 0.2 2.6 2 0 0 2 2 2 2 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII68402.1 - 1.7e-07 30.9 21.4 6.2e-07 29.2 8.0 2.7 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF912 PF06024.7 KII68402.1 - 0.02 14.9 0.6 0.037 14.0 0.1 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Glycophorin_A PF01102.13 KII68402.1 - 0.021 14.5 0.1 0.033 13.9 0.1 1.3 1 0 0 1 1 1 0 Glycophorin A rve PF00665.21 KII68404.1 - 3.2e-19 69.2 0.0 1.3e-18 67.2 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII68404.1 - 6.5e-15 55.0 0.1 1.3e-14 54.0 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.5 KII68404.1 - 0.0078 15.6 0.1 0.017 14.5 0.1 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DUF912 PF06024.7 KII68406.1 - 0.002 18.1 0.3 0.0028 17.6 0.2 1.3 1 1 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4448 PF14610.1 KII68406.1 - 0.045 13.2 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) CD34_antigen PF06365.7 KII68406.1 - 0.05 13.2 0.1 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Herpes_gE PF02480.11 KII68406.1 - 0.053 11.7 0.0 0.053 11.7 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Baculo_11_kDa PF06143.6 KII68406.1 - 0.065 12.6 0.2 0.092 12.1 0.1 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family stn_TNFRSF12A PF12191.3 KII68406.1 - 0.067 13.2 0.2 0.08 12.9 0.1 1.2 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain EphA2_TM PF14575.1 KII68406.1 - 0.15 12.4 0.5 0.21 12.0 0.4 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Rifin_STEVOR PF02009.11 KII68406.1 - 0.17 11.5 0.4 0.2 11.3 0.2 1.1 1 0 0 1 1 1 0 Rifin/stevor family Defensin_2 PF01097.13 KII68406.1 - 0.22 11.2 1.5 0.39 10.4 1.1 1.5 1 0 0 1 1 1 0 Arthropod defensin BNR PF02012.15 KII68408.1 - 0.00016 21.0 4.9 0.34 10.9 0.2 3.4 3 0 0 3 3 3 3 BNR/Asp-box repeat Argos PF11581.3 KII68409.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Antagonist of EGFR signalling, Argos rve PF00665.21 KII68414.1 - 0.00093 19.2 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS1595 PF12762.2 KII68415.1 - 2.4e-07 30.6 0.1 4.6e-07 29.7 0.1 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII68416.1 - 8.6e-08 32.0 0.0 5.7e-06 26.1 0.0 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease CT47 PF15623.1 KII68417.1 - 3.5 7.2 7.2 0.53 9.9 0.1 2.0 2 0 0 2 2 2 0 Cancer/testis gene family 47 DDE_1 PF03184.14 KII68418.1 - 2.1e-37 128.3 0.0 2.3e-37 128.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII68418.1 - 0.00023 20.9 0.0 0.0003 20.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RVT_1 PF00078.22 KII68419.1 - 1.4e-09 37.6 0.1 1.8e-09 37.2 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tbf5 PF06331.7 KII68419.1 - 0.0091 15.7 0.3 0.014 15.1 0.2 1.4 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Acyltransferase PF01553.16 KII68419.1 - 0.1 12.0 0.0 0.12 11.8 0.0 1.3 1 1 0 1 1 1 0 Acyltransferase SMC_hinge PF06470.8 KII68420.1 - 0.017 15.1 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain RNase_T PF00929.19 KII68421.1 - 0.029 14.6 0.4 0.48 10.6 0.3 2.0 1 1 0 1 1 1 0 Exonuclease rve PF00665.21 KII68422.1 - 3.2e-05 24.0 0.0 7e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Kunitz_BPTI PF00014.18 KII68423.1 - 0.00035 20.6 17.2 0.0006 19.9 6.8 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain rve PF00665.21 KII68424.1 - 2.7e-11 43.5 0.0 3.6e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII68424.1 - 0.009 15.5 0.0 0.016 14.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Kunitz_BPTI PF00014.18 KII68425.1 - 0.0088 16.2 4.0 0.0088 16.2 2.8 2.6 2 2 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain PAN_3 PF08277.7 KII68425.1 - 1.1 8.8 0.0 1.1 8.8 0.0 2.7 2 1 1 3 3 3 0 PAN-like domain Endothelin PF00322.12 KII68425.1 - 1.2 8.4 5.5 0.62 9.3 1.9 2.0 2 0 0 2 2 2 0 Endothelin family Tetraspannin PF00335.15 KII68426.1 - 3.3e-18 65.7 10.8 4e-18 65.5 7.5 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF1980 PF09323.5 KII68426.1 - 1.5 8.4 9.1 8.2 6.1 0.5 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1980) ABC_tran PF00005.22 KII68427.1 - 0.00038 20.7 0.0 0.00063 20.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ERAP1_C PF11838.3 KII68428.1 - 4.9e-31 108.1 0.1 5.7e-31 107.9 0.1 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Colicin_D PF11429.3 KII68428.1 - 0.079 13.1 0.0 0.45 10.6 0.0 2.2 2 0 0 2 2 2 0 Colicin D Peptidase_M1 PF01433.15 KII68429.1 - 0.0037 16.3 0.1 0.0043 16.2 0.1 1.0 1 0 0 1 1 1 1 Peptidase family M1 DUF1053 PF06327.9 KII68429.1 - 0.1 12.9 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) Peptidase_M1 PF01433.15 KII68430.1 - 9.3e-22 77.6 0.0 1.1e-21 77.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 KII68431.1 - 3.6e-05 23.1 0.0 4e-05 23.0 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain DUF3130 PF11328.3 KII68431.1 - 0.028 14.4 0.0 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3130 DUF3922 PF13059.1 KII68431.1 - 0.088 13.0 0.1 0.18 11.9 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3992) ERAP1_C PF11838.3 KII68432.1 - 5.1e-07 29.2 0.0 5.5e-07 29.1 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain DUF4217 PF13959.1 KII68432.1 - 0.0089 15.5 0.1 0.025 14.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) Peptidase_M1 PF01433.15 KII68433.1 - 3e-56 191.2 4.0 3.4e-56 191.0 2.8 1.0 1 0 0 1 1 1 1 Peptidase family M1 Herpes_V23 PF01802.12 KII68433.1 - 0.022 13.7 0.2 0.034 13.2 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein ERAP1_C PF11838.3 KII68434.1 - 2.7e-18 66.3 0.0 3.2e-18 66.0 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.15 KII68436.1 - 2.3e-83 280.4 1.3 2.8e-83 280.1 0.9 1.0 1 0 0 1 1 1 1 Peptidase family M1 Peptidase_MA_2 PF13485.1 KII68436.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase MA superfamily ARID PF01388.16 KII68437.1 - 1.6e-15 56.7 0.1 5.5e-15 55.0 0.1 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tudor-knot PF11717.3 KII68437.1 - 2.5e-08 33.4 0.2 6.1e-08 32.2 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 KII68437.1 - 0.0045 16.6 0.0 0.012 15.2 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MBT PF02820.13 KII68437.1 - 0.017 15.0 0.1 0.35 10.8 0.0 2.6 2 0 0 2 2 2 0 mbt repeat Ets PF00178.17 KII68438.1 - 6.2e-18 64.7 0.3 2.8e-17 62.6 0.3 1.9 2 1 0 2 2 2 1 Ets-domain RE_R_Pab1 PF09522.5 KII68438.1 - 0.006 16.5 0.0 0.0088 15.9 0.0 1.3 1 0 0 1 1 1 1 R.Pab1 restriction endonuclease ASFV_p27 PF06556.6 KII68438.1 - 0.048 13.5 0.7 0.075 12.9 0.5 1.4 1 1 0 1 1 1 0 IAP-like protein p27 C-terminus Reticulon PF02453.12 KII68439.1 - 5e-14 52.2 9.8 7.7e-14 51.6 6.8 1.2 1 0 0 1 1 1 1 Reticulon FtsH_ext PF06480.10 KII68439.1 - 0.8 9.9 2.6 1.6 8.8 1.8 1.5 1 0 0 1 1 1 0 FtsH Extracellular Rieske PF00355.21 KII68441.1 - 1.4e-14 53.3 0.1 3e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.9 KII68441.1 - 0.033 14.4 0.0 0.062 13.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquinol cytochrome reductase transmembrane region Nefa_Nip30_N PF10187.4 KII68442.1 - 1.3e-07 31.6 15.5 1.3e-07 31.6 10.8 1.5 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF342 PF03961.8 KII68442.1 - 0.48 8.7 6.5 0.5 8.7 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) MRP-63 PF14978.1 KII68442.1 - 5.2 7.5 7.5 2.1 8.8 0.3 2.4 1 1 1 2 2 2 0 Mitochondrial ribosome protein 63 PHO4 PF01384.15 KII68443.1 - 1.4e-52 178.4 0.7 1.4e-52 178.3 0.5 1.0 1 0 0 1 1 1 1 Phosphate transporter family DDE_Tnp_IS1595 PF12762.2 KII68445.1 - 0.022 14.5 0.0 0.14 11.9 0.0 2.0 1 1 0 1 1 1 0 ISXO2-like transposase domain DEC-1_C PF04626.8 KII68448.1 - 0.23 11.6 0.8 14 5.8 0.3 2.5 2 1 1 3 3 3 0 Dec-1 protein, C terminal region Prefoldin_2 PF01920.15 KII68449.1 - 2.4e-11 43.3 4.1 4.2e-11 42.5 2.8 1.4 1 1 0 1 1 1 1 Prefoldin subunit CAAP1 PF15335.1 KII68449.1 - 0.0076 16.4 1.8 0.0079 16.3 0.4 1.6 2 0 0 2 2 1 1 Caspase activity and apoptosis inhibitor 1 Prefoldin PF02996.12 KII68449.1 - 0.02 14.5 4.8 0.038 13.6 0.1 2.4 2 1 0 2 2 2 0 Prefoldin subunit HEPN PF05168.9 KII68449.1 - 0.025 14.4 0.4 0.18 11.6 0.0 1.9 1 1 1 2 2 2 0 HEPN domain CCDC-167 PF15188.1 KII68449.1 - 0.054 13.4 0.8 0.054 13.4 0.6 2.2 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 PEARLI-4 PF05278.7 KII68449.1 - 0.057 12.7 1.0 2.5 7.3 0.1 2.0 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF869 PF05911.6 KII68449.1 - 0.086 11.0 3.5 0.11 10.7 2.4 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) DUF651 PF04895.7 KII68449.1 - 0.21 11.2 1.8 3.7 7.2 0.0 2.0 1 1 1 2 2 2 0 Archaeal protein of unknown function (DUF651) DUF3847 PF12958.2 KII68449.1 - 0.29 10.9 5.9 0.48 10.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) Spc7 PF08317.6 KII68449.1 - 0.3 9.6 7.3 0.56 8.8 5.1 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein TMF_DNA_bd PF12329.3 KII68449.1 - 0.41 10.4 4.7 1.4 8.8 0.3 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Mnd1 PF03962.10 KII68449.1 - 0.6 9.7 5.1 2.5 7.7 0.1 2.0 2 0 0 2 2 2 0 Mnd1 family Myb_DNA-bind_4 PF13837.1 KII68449.1 - 0.73 10.0 4.0 1.4 9.1 0.1 2.3 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF3508 PF12018.3 KII68449.1 - 2 7.3 6.6 11 4.8 4.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3508) Sipho_Gp157 PF05565.6 KII68449.1 - 7.7 6.0 8.8 3.6 7.1 0.9 2.0 1 1 1 2 2 2 0 Siphovirus Gp157 Ribosomal_S15 PF00312.17 KII68450.1 - 5.5e-08 32.4 2.0 9.2e-08 31.7 1.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 rve PF00665.21 KII68451.1 - 1.7e-05 24.8 0.0 3.4e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII68451.1 - 0.027 13.8 0.0 0.06 12.7 0.0 1.6 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger E2_bind PF08825.5 KII68451.1 - 0.036 13.8 0.0 0.11 12.3 0.0 1.7 1 1 0 1 1 1 0 E2 binding domain PIF1 PF05970.9 KII68452.1 - 1.8e-33 115.9 0.4 2.2e-33 115.7 0.3 1.1 1 0 0 1 1 1 1 PIF1-like helicase UvrD_C_2 PF13538.1 KII68452.1 - 4.6e-08 33.1 0.0 1.2e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.9 KII68452.1 - 1.8e-06 26.0 0.0 2.4e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.13 KII68452.1 - 0.00059 19.4 0.0 0.00092 18.8 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase UPF0228 PF05727.6 KII68452.1 - 0.033 13.9 0.0 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0228) PIF1 PF05970.9 KII68453.1 - 1.3e-36 126.3 0.0 1.8e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 KII68453.1 - 4.9e-08 32.7 0.0 9.2e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII68453.1 - 2e-05 24.7 0.0 6.3e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII68453.1 - 0.00049 19.7 0.0 0.0064 16.2 0.0 2.5 3 0 0 3 3 3 1 Part of AAA domain AFG1_ATPase PF03969.11 KII68453.1 - 0.0079 15.0 0.0 0.011 14.5 0.0 1.2 1 0 0 1 1 1 1 AFG1-like ATPase AAA_5 PF07728.9 KII68453.1 - 0.0089 15.7 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KII68453.1 - 0.013 15.5 0.0 0.17 11.8 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 KII68453.1 - 0.017 15.0 0.0 0.071 13.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KII68453.1 - 0.028 13.8 0.0 0.077 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 KII68453.1 - 0.047 13.5 0.4 0.13 12.1 0.1 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit UPF0079 PF02367.12 KII68453.1 - 0.12 11.9 0.1 0.22 11.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DAP3 PF10236.4 KII68453.1 - 0.12 11.2 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Helitron_like_N PF14214.1 KII68454.1 - 1.2e-17 64.2 0.0 1.2e-17 64.2 0.0 2.6 3 1 0 3 3 3 1 Helitron helicase-like domain at N-terminus LRV_FeS PF05484.6 KII68454.1 - 0.053 13.0 0.2 0.13 11.8 0.1 1.7 1 0 0 1 1 1 0 LRV protein FeS4 cluster DUF4507 PF14964.1 KII68456.1 - 6.8e-15 54.6 0.0 4.2e-10 38.9 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4507) SEA PF01390.15 KII68457.1 - 1.4e-05 24.6 0.3 1.4e-05 24.6 0.2 1.9 2 0 0 2 2 2 1 SEA domain FLYWCH PF04500.11 KII68459.1 - 2.4e-17 62.5 2.1 9.1e-17 60.7 1.4 2.1 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 KII68459.1 - 1.9e-09 37.5 0.0 4.7e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain NIF PF03031.13 KII68460.1 - 2e-26 92.5 0.2 4.3e-26 91.4 0.1 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.2 KII68460.1 - 0.0009 19.0 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 KII68460.1 - 0.0026 17.8 0.1 0.012 15.7 0.0 2.3 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain NOT2_3_5 PF04153.13 KII68461.1 - 2.7e-31 108.2 8.6 2.7e-31 108.2 6.0 1.2 1 1 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF1824 PF08854.5 KII68462.1 - 0.034 13.7 0.0 0.045 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1824) DNA_pol_E_B PF04042.11 KII68463.1 - 1.6e-26 92.8 0.3 2e-26 92.5 0.2 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B YrhK PF14145.1 KII68463.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 YrhK-like protein MGC-24 PF05283.6 KII68464.1 - 2 8.1 3.9 1.7 8.4 1.0 1.8 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24) Syja_N PF02383.13 KII68466.1 - 2.3e-75 253.3 0.8 3.2e-75 252.8 0.6 1.2 1 0 0 1 1 1 1 SacI homology domain FlgN PF05130.7 KII68466.1 - 0.052 13.7 0.4 0.11 12.7 0.3 1.5 1 0 0 1 1 1 0 FlgN protein DUF1624 PF07786.7 KII68466.1 - 0.06 12.6 0.4 1.6 7.9 0.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1624) KH_1 PF00013.24 KII68468.1 - 6.6e-12 44.8 0.1 1.1e-11 44.1 0.1 1.3 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KII68468.1 - 0.0068 16.0 0.0 0.017 14.8 0.0 1.7 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 KII68468.1 - 0.065 12.7 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 KH domain Mga PF05043.8 KII68469.1 - 0.01 16.1 2.2 0.012 15.8 0.6 1.8 2 0 0 2 2 2 0 Mga helix-turn-helix domain DUF1492 PF07374.6 KII68469.1 - 0.011 15.8 0.6 0.019 15.0 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) DUF1864 PF08933.6 KII68469.1 - 0.013 14.0 0.1 0.016 13.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1864) Glyco_transf_18 PF15024.1 KII68470.1 - 1e-19 70.3 3.2 1.1e-19 70.1 2.2 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 18 DEK_C PF08766.6 KII68470.1 - 0.059 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 DEK C terminal domain AAA_29 PF13555.1 KII68471.1 - 0.0046 16.4 0.0 0.0079 15.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 KII68471.1 - 0.0068 15.6 0.0 0.0085 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 KII68471.1 - 0.0091 16.2 0.0 0.017 15.3 0.0 1.5 2 0 0 2 2 2 1 ABC transporter T2SE PF00437.15 KII68471.1 - 0.035 13.0 0.0 0.035 13.0 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein G-alpha PF00503.15 KII68471.1 - 0.036 12.7 0.1 0.036 12.7 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit DUF815 PF05673.8 KII68471.1 - 0.047 12.5 0.0 0.054 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Na_Ca_ex PF01699.19 KII68473.1 - 4.3e-08 32.8 0.2 1.2e-07 31.4 0.0 1.7 1 1 1 2 2 2 1 Sodium/calcium exchanger protein DUF3021 PF11457.3 KII68473.1 - 0.027 14.3 0.3 0.036 13.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) Caa3_CtaG PF09678.5 KII68473.1 - 0.036 12.9 0.2 0.048 12.5 0.2 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) RPA_C PF08784.6 KII68474.1 - 7.3e-13 48.8 0.0 2e-12 47.4 0.0 1.7 2 0 0 2 2 2 1 Replication protein A C terminal EB1 PF03271.12 KII68476.1 - 4.4e-06 26.6 0.5 1.4e-05 25.0 0.3 1.9 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 KII68476.1 - 6.5e-05 22.9 1.7 6.7e-05 22.8 0.6 1.5 2 0 0 2 2 2 1 Calponin homology (CH) domain D123 PF07065.9 KII68479.1 - 7.5e-35 120.4 1.1 3e-30 105.3 0.0 2.0 1 1 1 2 2 2 2 D123 IU_nuc_hydro PF01156.14 KII68480.1 - 1.2e-43 149.4 0.0 1.4e-43 149.2 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase LAP2alpha PF11560.3 KII68480.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha CDC37_M PF08565.6 KII68481.1 - 0.0064 15.9 0.1 0.0068 15.9 0.1 1.0 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain Toxin_17 PF08086.6 KII68481.1 - 0.97 9.5 3.8 0.35 10.9 0.4 1.9 3 0 0 3 3 3 0 Ergtoxin family DDE_Tnp_IS1595 PF12762.2 KII68482.1 - 5.4e-18 65.2 0.2 7.6e-18 64.7 0.1 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain BNR PF02012.15 KII68484.1 - 0.00032 20.0 8.5 4.9 7.3 0.0 4.8 4 0 0 4 4 4 3 BNR/Asp-box repeat zf-RING-like PF08746.6 KII68484.1 - 0.021 14.7 0.3 0.085 12.8 0.2 2.0 1 0 0 1 1 1 0 RING-like domain Pex14_N PF04695.8 KII68486.1 - 0.039 13.9 0.2 0.066 13.2 0.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DDE_3 PF13358.1 KII68491.1 - 0.024 14.3 0.0 0.055 13.2 0.0 1.6 2 0 0 2 2 2 0 DDE superfamily endonuclease FANCF PF11107.3 KII68491.1 - 0.042 13.1 0.0 0.048 12.9 0.0 1.1 1 0 0 1 1 1 0 Fanconi anemia group F protein (FANCF) GerE PF00196.14 KII68491.1 - 0.047 13.0 0.0 0.083 12.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_23 PF13384.1 KII68491.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF751 PF05421.6 KII68492.1 - 0.03 14.6 1.7 0.03 14.6 1.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF751) DUF3099 PF11298.3 KII68492.1 - 0.032 13.9 0.4 0.032 13.9 0.2 2.8 3 2 0 3 3 3 0 Protein of unknown function (DUF3099) DUF4293 PF14126.1 KII68492.1 - 0.16 11.9 11.4 1.4 8.8 7.8 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4293) ACR_tran PF00873.14 KII68493.1 - 0.042 11.2 1.2 0.063 10.6 0.8 1.2 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family PGG PF13962.1 KII68493.1 - 2.3 7.8 16.5 0.84 9.2 0.6 2.8 1 1 2 3 3 3 0 Domain of unknown function Tetraspannin PF00335.15 KII68493.1 - 9 5.5 9.9 2.2 7.5 3.5 2.0 2 0 0 2 2 2 0 Tetraspanin family Rsm22 PF09243.5 KII68497.1 - 0.026 13.5 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 PA28_beta PF02252.13 KII68499.1 - 7e-48 161.9 0.2 1.1e-47 161.3 0.1 1.3 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.13 KII68499.1 - 0.00091 19.3 0.0 0.0021 18.1 0.0 1.6 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit MutS_V PF00488.16 KII68501.1 - 1.8e-05 24.2 0.0 2.1e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 MutS domain V TAFH PF07531.9 KII68501.1 - 0.0042 16.7 0.0 0.0065 16.0 0.0 1.2 1 0 0 1 1 1 1 NHR1 homology to TAF Annexin PF00191.15 KII68503.1 - 2.5e-06 27.3 2.2 0.00033 20.5 0.2 3.2 3 0 0 3 3 3 2 Annexin DDE_Tnp_IS1595 PF12762.2 KII68504.1 - 1.6e-09 37.7 0.0 7.1e-09 35.6 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain Phage_Mu_Gam PF07352.7 KII68504.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein DUF4389 PF14333.1 KII68506.1 - 0.014 15.0 0.1 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) BDM PF10684.4 KII68506.1 - 0.061 13.5 0.1 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative biofilm-dependent modulation protein Kelch_6 PF13964.1 KII68508.1 - 7.1e-26 89.2 12.3 9.1e-05 22.4 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII68508.1 - 1.9e-24 85.1 8.0 4.4e-05 23.1 0.0 5.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII68508.1 - 3.9e-19 67.9 5.9 0.0037 16.7 0.0 6.5 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.1 KII68508.1 - 1.2e-18 66.7 10.9 0.0014 18.7 0.0 6.0 4 2 2 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.10 KII68508.1 - 9.8e-12 44.1 7.9 0.011 15.4 0.1 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 KII68508.1 - 1.4e-09 37.6 9.3 0.28 11.1 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Rax2 PF12768.2 KII68508.1 - 0.00025 20.3 0.0 0.00071 18.8 0.0 1.7 1 1 1 2 2 2 1 Cortical protein marker for cell polarity DUF3128 PF11326.3 KII68508.1 - 0.016 15.3 0.0 2.2 8.4 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3128) DDE_1 PF03184.14 KII68509.1 - 1.5e-07 30.8 0.2 0.00077 18.6 0.0 2.3 2 0 0 2 2 2 2 DDE superfamily endonuclease DUF1882 PF08966.6 KII68509.1 - 0.11 12.4 1.8 3 7.8 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1882) MULE PF10551.4 KII68511.1 - 0.0077 16.3 0.1 0.013 15.6 0.1 1.4 1 0 0 1 1 1 1 MULE transposase domain Kelch_1 PF01344.20 KII68512.1 - 1.1e-22 79.2 5.1 1.4e-08 34.1 0.2 3.1 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 KII68512.1 - 9.9e-18 63.5 5.2 7e-05 22.8 0.1 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII68512.1 - 5.4e-15 55.0 2.9 0.00016 21.7 0.2 4.0 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII68512.1 - 9.5e-11 41.3 8.6 4.3e-05 23.1 0.1 3.8 1 1 2 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII68512.1 - 6.3e-10 38.4 6.3 0.0039 16.9 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII68512.1 - 9.7e-05 22.2 6.7 0.33 10.9 0.0 3.6 3 1 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 KII68513.1 - 8e-06 25.3 1.2 0.00085 18.8 0.3 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 KII68513.1 - 0.00035 20.6 0.2 0.0068 16.5 0.1 2.2 2 0 0 2 2 2 1 Kelch motif DUF3328 PF11807.3 KII68518.1 - 0.087 12.4 0.3 0.78 9.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) Syntaxin_2 PF14523.1 KII68518.1 - 0.23 11.4 1.6 2.4 8.2 0.3 2.2 2 0 0 2 2 2 0 Syntaxin-like protein DDE_3 PF13358.1 KII68524.1 - 4.2e-13 49.2 0.2 8.3e-13 48.3 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 KII68524.1 - 0.046 12.4 0.1 0.071 11.8 0.1 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain PEX-1N PF09262.6 KII68528.1 - 0.077 13.0 0.0 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal rve PF00665.21 KII68528.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Serpin PF00079.15 KII68531.1 - 3e-18 66.1 1.6 3.2e-18 66.0 1.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.21 KII68535.1 - 1.4e-24 86.4 0.0 2.8e-24 85.5 0.0 1.4 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII68535.1 - 0.00023 20.6 0.0 0.0005 19.5 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain DDE_3 PF13358.1 KII68537.1 - 6.7e-15 55.1 0.0 7.6e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease AdoHcyase PF05221.12 KII68538.1 - 2e-12 46.6 0.0 9.7e-12 44.3 0.0 2.0 1 1 1 2 2 2 1 S-adenosyl-L-homocysteine hydrolase Serpin PF00079.15 KII68539.1 - 1.7e-15 57.0 0.1 2.1e-15 56.7 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) E_raikovi_mat PF06360.6 KII68541.1 - 0.28 11.4 7.1 0.64 10.2 0.7 2.4 2 1 0 2 2 2 0 Euplotes raikovi mating pheromone PADR1 PF08063.7 KII68546.1 - 0.11 11.8 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 PADR1 (NUC008) domain Citrate_synt PF00285.16 KII68550.1 - 3.2e-13 49.1 0.0 8.8e-09 34.5 0.0 2.0 2 0 0 2 2 2 2 Citrate synthase TRI9 PF08195.6 KII68551.1 - 0.032 13.8 0.1 0.065 12.8 0.1 1.4 1 0 0 1 1 1 0 TRI9 protein DDE_3 PF13358.1 KII68553.1 - 0.011 15.5 0.0 0.03 14.0 0.0 1.6 1 1 0 1 1 1 0 DDE superfamily endonuclease DDE_3 PF13358.1 KII68556.1 - 2.2e-26 92.3 0.0 2.7e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII68556.1 - 0.00027 20.1 0.0 0.00034 19.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Arm PF00514.18 KII68558.1 - 0.00017 21.2 0.1 0.41 10.5 0.0 3.8 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KII68558.1 - 0.029 14.8 0.0 1.8 9.1 0.0 2.4 3 0 0 3 3 3 0 HEAT-like repeat Arm PF00514.18 KII68559.1 - 8e-10 38.1 4.9 0.0039 16.9 0.1 3.6 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat MOZART2 PF12926.2 KII68559.1 - 0.0055 16.2 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated HEAT_2 PF13646.1 KII68559.1 - 0.0087 16.3 0.0 0.036 14.3 0.0 2.1 1 1 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.1 KII68559.1 - 0.024 15.1 1.0 0.59 10.6 0.1 2.8 2 1 1 3 3 3 0 HEAT-like repeat HEAT PF02985.17 KII68559.1 - 0.59 10.3 2.8 14 6.0 0.1 3.5 4 0 0 4 4 4 0 HEAT repeat DDE_Tnp_IS1595 PF12762.2 KII68560.1 - 7.3e-10 38.8 0.0 9.1e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Rep_fac-A_C PF08646.5 KII68561.1 - 6.2e-35 120.0 0.1 1.6e-34 118.7 0.0 1.7 2 0 0 2 2 2 1 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 KII68561.1 - 0.00011 21.9 0.1 0.034 14.0 0.0 3.1 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain Ribosomal_S4 PF00163.14 KII68563.1 - 5.3e-23 81.2 1.2 5.3e-23 81.2 0.8 1.9 3 0 0 3 3 3 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 KII68563.1 - 4.4e-11 42.0 0.5 1.1e-10 40.7 0.3 1.7 1 0 0 1 1 1 1 S4 domain SPARC_Ca_bdg PF10591.4 KII68565.1 - 0.046 13.7 0.1 0.079 12.9 0.1 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region SHP PF03579.8 KII68566.1 - 0.17 11.2 0.1 0.17 11.2 0.1 1.9 2 0 0 2 2 2 0 Small hydrophobic protein FrhB_FdhB_C PF04432.8 KII68569.1 - 0.033 13.6 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus Gln-synt_C PF00120.19 KII68573.1 - 0.026 13.6 0.0 0.028 13.5 0.0 1.1 1 0 0 1 1 1 0 Glutamine synthetase, catalytic domain DDE_3 PF13358.1 KII68573.1 - 0.03 14.0 0.1 0.038 13.7 0.0 1.3 1 1 0 1 1 1 0 DDE superfamily endonuclease Ras PF00071.17 KII68575.1 - 7.1e-51 171.8 0.1 8e-51 171.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII68575.1 - 2.4e-13 50.6 0.0 4e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII68575.1 - 1.3e-10 40.7 0.0 1.7e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KII68575.1 - 2.3e-05 23.9 0.4 0.00014 21.3 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF2666 PF10869.3 KII68576.1 - 0.047 13.7 1.0 1.4 8.9 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) Rad33 PF08730.5 KII68576.1 - 0.055 12.9 0.1 0.061 12.7 0.1 1.2 1 0 0 1 1 1 0 Rad33 Sec8_exocyst PF04048.9 KII68576.1 - 0.12 12.0 0.3 0.36 10.4 0.1 1.7 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF4041 PF13250.1 KII68576.1 - 0.86 9.2 4.8 11 5.7 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4041) VEGF_C PF14554.1 KII68577.1 - 0.15 11.9 0.6 0.15 11.9 0.4 1.6 2 0 0 2 2 2 0 VEGF heparin-binding domain RTBV_P46 PF06216.6 KII68578.1 - 0.027 13.3 1.6 0.032 13.0 1.1 1.1 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein rve PF00665.21 KII68579.1 - 1.8e-12 47.4 0.2 4.2e-12 46.2 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII68579.1 - 0.00025 20.4 0.4 0.0042 16.5 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Defensin_beta PF00711.14 KII68581.1 - 0.076 12.9 0.5 0.076 12.9 0.4 1.6 2 0 0 2 2 2 0 Beta defensin THOC7 PF05615.8 KII68582.1 - 0.00044 20.5 7.6 0.00044 20.5 5.3 2.2 1 1 1 2 2 2 1 Tho complex subunit 7 CENP-F_leu_zip PF10473.4 KII68582.1 - 0.00069 19.4 14.1 0.0014 18.4 9.8 1.5 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4200 PF13863.1 KII68582.1 - 0.001 19.0 18.8 0.0091 15.9 7.2 2.7 1 1 1 2 2 2 2 Domain of unknown function (DUF4200) IncA PF04156.9 KII68582.1 - 0.0044 16.6 13.1 0.31 10.6 3.5 2.0 1 1 1 2 2 2 2 IncA protein MscS_porin PF12795.2 KII68582.1 - 0.0073 15.6 6.4 0.019 14.3 4.4 1.8 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain AAA_27 PF13514.1 KII68582.1 - 0.0077 13.9 6.6 0.0094 13.7 4.6 1.2 1 0 0 1 1 1 1 AAA domain PspA_IM30 PF04012.7 KII68582.1 - 0.011 15.1 9.9 0.41 9.9 1.3 2.2 1 1 1 2 2 2 0 PspA/IM30 family Tropomyosin_1 PF12718.2 KII68582.1 - 0.013 15.3 16.0 0.03 14.1 3.3 2.2 1 1 1 2 2 2 0 Tropomyosin like IFT57 PF10498.4 KII68582.1 - 0.013 14.2 11.5 0.017 13.9 8.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 FliJ PF02050.11 KII68582.1 - 0.017 15.1 12.4 2 8.4 6.4 2.3 1 1 1 2 2 2 0 Flagellar FliJ protein WEMBL PF05701.6 KII68582.1 - 0.019 13.4 11.4 0.025 13.0 7.9 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Fib_alpha PF08702.5 KII68582.1 - 0.036 14.1 11.7 0.031 14.3 4.7 2.1 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4047 PF13256.1 KII68582.1 - 0.052 13.5 12.0 0.068 13.1 7.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) NPV_P10 PF05531.7 KII68582.1 - 0.057 13.6 1.8 0.25 11.5 0.2 2.2 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_assoc_C PF09821.4 KII68582.1 - 0.075 13.3 1.1 0.11 12.8 0.7 1.2 1 0 0 1 1 1 0 C-terminal AAA-associated domain DUF4201 PF13870.1 KII68582.1 - 0.075 12.4 15.0 9.2 5.6 10.4 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) KxDL PF10241.4 KII68582.1 - 0.076 12.9 0.6 0.45 10.4 0.1 2.2 1 1 0 2 2 2 0 Uncharacterized conserved protein DUF948 PF06103.6 KII68582.1 - 0.13 12.1 4.6 0.076 12.8 0.8 2.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF904 PF06005.7 KII68582.1 - 0.14 12.5 16.8 0.63 10.3 6.4 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF365 PF04033.7 KII68582.1 - 0.14 12.1 1.0 0.33 10.9 0.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF365) APG6 PF04111.7 KII68582.1 - 0.16 11.0 14.8 0.34 9.9 10.2 1.5 1 1 0 1 1 1 0 Autophagy protein Apg6 ADIP PF11559.3 KII68582.1 - 0.16 11.8 14.0 4.1 7.2 2.8 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.10 KII68582.1 - 0.19 10.9 6.5 0.21 10.7 4.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Leu_zip PF15294.1 KII68582.1 - 0.19 10.7 9.9 0.23 10.5 6.8 1.2 1 0 0 1 1 1 0 Leucine zipper AAA_13 PF13166.1 KII68582.1 - 0.19 10.1 15.2 0.83 8.0 10.5 1.7 1 1 0 1 1 1 0 AAA domain TMF_DNA_bd PF12329.3 KII68582.1 - 0.2 11.5 18.6 0.36 10.6 0.6 3.4 1 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 KII68582.1 - 0.24 10.9 16.8 0.88 9.1 0.2 3.6 1 1 2 3 3 3 0 Septum formation initiator GAS PF13851.1 KII68582.1 - 0.27 10.4 16.5 0.79 8.8 10.3 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Bap31 PF05529.7 KII68582.1 - 0.27 10.6 11.3 1.9e+02 1.3 7.8 2.1 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like Spc7 PF08317.6 KII68582.1 - 0.33 9.5 17.2 0.11 11.1 7.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein HAUS-augmin3 PF14932.1 KII68582.1 - 0.44 9.7 11.2 0.58 9.2 6.0 1.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DivIVA PF05103.8 KII68582.1 - 0.47 10.5 13.2 0.078 13.0 5.3 2.1 1 1 1 2 2 2 0 DivIVA protein DUF3450 PF11932.3 KII68582.1 - 0.5 9.5 11.9 0.24 10.6 2.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) RmuC PF02646.11 KII68582.1 - 0.53 9.0 8.4 1.4 7.6 0.6 2.0 1 1 1 2 2 2 0 RmuC family Sipho_Gp157 PF05565.6 KII68582.1 - 0.62 9.6 14.6 0.21 11.1 1.0 2.4 1 1 2 3 3 3 0 Siphovirus Gp157 Laminin_I PF06008.9 KII68582.1 - 0.66 9.2 10.7 0.43 9.8 5.1 1.9 1 1 1 2 2 2 0 Laminin Domain I Macoilin PF09726.4 KII68582.1 - 0.71 8.0 12.0 0.79 7.9 8.3 1.0 1 0 0 1 1 1 0 Transmembrane protein Mnd1 PF03962.10 KII68582.1 - 0.78 9.3 14.9 2.6 7.6 10.3 1.8 1 1 0 1 1 1 0 Mnd1 family Rootletin PF15035.1 KII68582.1 - 0.91 9.4 11.6 2.9 7.8 0.2 2.1 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Occludin_ELL PF07303.8 KII68582.1 - 1.2 9.8 12.0 2.8 8.7 1.1 2.3 1 1 1 2 2 2 0 Occludin homology domain COG2 PF06148.6 KII68582.1 - 1.3 8.8 6.8 3.2 7.6 0.4 3.0 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Med9 PF07544.8 KII68582.1 - 1.5 8.5 15.7 3.8 7.2 0.5 3.9 2 2 2 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Phage_GP20 PF06810.6 KII68582.1 - 1.8 8.0 14.3 2.7 7.4 5.9 2.6 1 1 1 2 2 2 0 Phage minor structural protein GP20 ATG16 PF08614.6 KII68582.1 - 1.8 8.3 16.0 2.3 8.0 6.4 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Sin3_corepress PF08295.7 KII68582.1 - 2.3 8.0 7.7 0.53 10.0 2.6 2.1 1 1 2 3 3 2 0 Sin3 family co-repressor Striatin PF08232.7 KII68582.1 - 2.5 8.4 11.7 74 3.6 8.1 2.2 1 1 0 1 1 1 0 Striatin family Syntaxin-6_N PF09177.6 KII68582.1 - 2.5 8.5 10.6 6.1 7.3 0.3 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal FlaC_arch PF05377.6 KII68582.1 - 2.5 8.0 8.0 4.7 7.1 0.2 3.3 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Phospho_p8 PF10195.4 KII68582.1 - 2.7 7.9 6.2 1.1 9.1 0.8 2.5 2 1 1 3 3 3 0 DNA-binding nuclear phosphoprotein p8 DUF812 PF05667.6 KII68582.1 - 2.8 6.3 15.2 24 3.2 10.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Rabaptin PF03528.10 KII68582.1 - 2.9 7.8 14.5 52 3.8 10.0 2.1 1 1 0 1 1 1 0 Rabaptin DUF4140 PF13600.1 KII68582.1 - 2.9 8.3 7.1 4.4 7.8 0.5 3.0 1 1 3 4 4 4 0 N-terminal domain of unknown function (DUF4140) DUF1664 PF07889.7 KII68582.1 - 3.8 7.3 8.2 12 5.7 3.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.16 KII68582.1 - 4.4 7.3 9.3 19 5.2 0.1 3.3 2 1 1 3 3 3 0 bZIP transcription factor Atg14 PF10186.4 KII68582.1 - 5.4 5.8 14.8 45 2.8 9.7 2.1 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ABC_tran PF00005.22 KII68582.1 - 5.6 7.2 5.9 19 5.5 4.1 1.8 1 1 0 1 1 1 0 ABC transporter RTBV_P46 PF06216.6 KII68582.1 - 6.4 5.5 10.6 0.94 8.2 1.3 2.0 1 1 1 2 2 2 0 Rice tungro bacilliform virus P46 protein FlxA PF14282.1 KII68582.1 - 7.3 6.5 13.7 69 3.4 9.3 2.5 1 1 1 2 2 2 0 FlxA-like protein DegQ PF08181.6 KII68582.1 - 7.5 6.3 8.1 0.38 10.4 0.9 2.5 3 0 0 3 3 2 0 DegQ (SacQ) family Cast PF10174.4 KII68583.1 - 0.024 12.7 3.1 0.025 12.6 2.1 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone MscS_porin PF12795.2 KII68583.1 - 0.027 13.7 5.0 0.033 13.4 3.5 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain PGA2 PF07543.7 KII68583.1 - 0.14 11.9 3.0 0.31 10.8 2.1 1.7 1 1 0 1 1 1 0 Protein trafficking PGA2 DUF4284 PF14112.1 KII68583.1 - 0.3 11.5 4.3 0.81 10.1 2.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4284) THOC7 PF05615.8 KII68583.1 - 0.49 10.6 9.0 0.69 10.1 2.3 2.0 1 1 1 2 2 2 0 Tho complex subunit 7 ATP-synt_B PF00430.13 KII68583.1 - 1.8 8.4 5.6 2.7 7.8 3.9 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Tup_N PF08581.5 KII68583.1 - 2.6 8.2 12.9 0.49 10.6 4.5 2.4 2 1 0 2 2 2 0 Tup N-terminal Fib_alpha PF08702.5 KII68583.1 - 3.9 7.5 7.6 12 5.9 5.3 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.4 KII68584.1 - 4.2e-06 26.6 13.4 0.0017 18.1 4.5 2.2 1 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Macoilin PF09726.4 KII68584.1 - 0.00019 19.8 11.3 0.00022 19.6 7.8 1.0 1 0 0 1 1 1 1 Transmembrane protein THOC7 PF05615.8 KII68584.1 - 0.00036 20.8 5.4 0.00036 20.8 3.7 2.2 1 1 1 2 2 2 1 Tho complex subunit 7 GAS PF13851.1 KII68584.1 - 0.0015 17.7 16.2 0.0083 15.3 8.3 2.0 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding DUF4200 PF13863.1 KII68584.1 - 0.0031 17.4 19.2 0.0079 16.1 8.1 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4200) Occludin_ELL PF07303.8 KII68584.1 - 0.0034 18.0 10.3 0.013 16.1 7.1 1.8 1 1 0 1 1 1 1 Occludin homology domain MAD PF05557.8 KII68584.1 - 0.0041 15.2 10.3 0.0052 14.9 7.1 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein IncA PF04156.9 KII68584.1 - 0.0053 16.3 15.1 0.24 10.9 10.4 2.2 1 1 0 1 1 1 1 IncA protein Tropomyosin_1 PF12718.2 KII68584.1 - 0.0063 16.3 14.6 0.13 12.0 3.8 2.2 1 1 1 2 2 2 2 Tropomyosin like DUF4618 PF15397.1 KII68584.1 - 0.0068 15.7 10.2 0.011 15.0 7.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4618) Spc7 PF08317.6 KII68584.1 - 0.016 13.8 15.8 0.045 12.4 10.9 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Vac_Fusion PF02346.11 KII68584.1 - 0.023 14.1 7.7 0.032 13.6 0.1 2.9 2 1 0 2 2 2 0 Chordopoxvirus fusion protein TMF_DNA_bd PF12329.3 KII68584.1 - 0.044 13.5 16.0 5.4 6.8 0.4 3.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF659 PF04937.10 KII68584.1 - 0.065 12.7 0.8 0.16 11.4 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF 659) Rogdi_lz PF10259.4 KII68584.1 - 0.069 12.2 2.7 0.091 11.8 1.8 1.2 1 1 0 1 1 1 0 Rogdi leucine zipper containing protein DUF1741 PF08427.5 KII68584.1 - 0.075 12.4 5.3 0.086 12.2 3.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1741) Ins_P5_2-kin PF06090.7 KII68584.1 - 0.094 11.7 2.4 0.1 11.6 1.7 1.1 1 0 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase DUF4164 PF13747.1 KII68584.1 - 0.13 12.4 6.4 0.12 12.4 0.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) AAA_13 PF13166.1 KII68584.1 - 0.14 10.6 12.7 0.25 9.7 8.8 1.5 1 1 0 1 1 1 0 AAA domain FliJ PF02050.11 KII68584.1 - 0.14 12.2 14.4 14 5.7 1.2 2.8 1 1 2 3 3 3 0 Flagellar FliJ protein NAAA-beta PF15508.1 KII68584.1 - 0.15 12.3 0.8 1.3 9.4 0.3 2.0 1 1 1 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase BLOC1_2 PF10046.4 KII68584.1 - 0.16 12.1 8.3 0.83 9.8 1.6 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IMD PF08397.6 KII68584.1 - 0.18 11.1 13.8 0.85 8.8 1.0 2.0 1 1 1 2 2 2 0 IRSp53/MIM homology domain DUF948 PF06103.6 KII68584.1 - 0.18 11.6 2.8 0.86 9.5 0.4 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) GreA_GreB_N PF03449.10 KII68584.1 - 0.23 11.5 7.1 2.8 8.0 1.4 2.7 1 1 1 2 2 2 0 Transcription elongation factor, N-terminal CALCOCO1 PF07888.6 KII68584.1 - 0.23 9.6 12.1 0.57 8.4 8.3 1.6 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ALMT PF11744.3 KII68584.1 - 0.23 10.0 3.3 0.26 9.9 2.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DivIC PF04977.10 KII68584.1 - 0.25 10.8 13.2 1.6 8.2 0.2 3.5 1 1 2 3 3 3 0 Septum formation initiator Seryl_tRNA_N PF02403.17 KII68584.1 - 0.27 11.2 11.9 1.7 8.7 1.0 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ADIP PF11559.3 KII68584.1 - 0.34 10.7 13.3 1.1 9.1 9.2 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding CENP-Q PF13094.1 KII68584.1 - 0.36 10.8 10.2 0.6 10.1 7.1 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF241 PF03087.9 KII68584.1 - 0.4 10.1 12.3 2.1 7.7 8.6 1.8 1 1 0 1 1 1 0 Arabidopsis protein of unknown function K167R PF08065.7 KII68584.1 - 0.43 10.7 3.8 0.56 10.3 2.6 1.3 1 0 0 1 1 1 0 K167R (NUC007) repeat DUF724 PF05266.9 KII68584.1 - 0.47 10.0 14.7 15 5.1 10.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) ATG16 PF08614.6 KII68584.1 - 0.56 10.0 15.1 3.8 7.2 1.4 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ApoLp-III PF07464.6 KII68584.1 - 0.59 10.1 8.4 0.081 12.9 2.8 1.7 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Spc42p PF11544.3 KII68584.1 - 0.64 9.9 11.3 4.9 7.1 3.2 2.3 1 1 0 2 2 2 0 Spindle pole body component Spc42p TSC22 PF01166.13 KII68584.1 - 0.68 9.9 11.6 1.3 9.0 1.5 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family DUF1192 PF06698.6 KII68584.1 - 0.7 9.7 5.5 20 5.0 0.0 3.6 3 1 1 4 4 3 0 Protein of unknown function (DUF1192) Mnd1 PF03962.10 KII68584.1 - 0.73 9.4 13.1 2.1 7.9 6.0 2.0 1 1 1 2 2 2 0 Mnd1 family DUF4094 PF13334.1 KII68584.1 - 0.74 10.2 9.5 1.4 9.3 2.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) Sec2p PF06428.6 KII68584.1 - 0.83 9.5 0.1 0.83 9.5 0.0 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p APG6 PF04111.7 KII68584.1 - 0.94 8.4 14.2 1.9 7.4 9.9 1.5 1 1 0 1 1 1 0 Autophagy protein Apg6 Fmp27_WPPW PF10359.4 KII68584.1 - 1.1 7.6 12.3 2.9 6.1 7.2 1.9 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Fib_alpha PF08702.5 KII68584.1 - 1.1 9.3 11.8 0.78 9.8 5.0 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HR1 PF02185.11 KII68584.1 - 1.2 8.9 13.0 0.58 9.9 1.1 3.4 1 1 2 3 3 3 0 Hr1 repeat TPR_MLP1_2 PF07926.7 KII68584.1 - 1.3 8.7 14.4 15 5.2 9.8 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Otopetrin PF03189.8 KII68584.1 - 1.3 7.9 3.5 1.4 7.8 2.4 1.0 1 0 0 1 1 1 0 Otopetrin Tup_N PF08581.5 KII68584.1 - 1.4 9.1 16.4 1.3 9.2 4.9 2.3 1 1 1 2 2 2 0 Tup N-terminal bZIP_1 PF00170.16 KII68584.1 - 1.5 8.8 9.9 3 7.8 0.6 3.3 1 1 2 3 3 3 0 bZIP transcription factor Sin3_corepress PF08295.7 KII68584.1 - 1.5 8.6 6.8 1.3 8.8 3.5 1.7 1 1 1 2 2 2 0 Sin3 family co-repressor Cep57_CLD_2 PF14197.1 KII68584.1 - 1.5 8.7 10.2 4.6 7.2 0.5 2.5 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 DUF4337 PF14235.1 KII68584.1 - 1.6 8.5 7.3 2.8 7.7 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) DivIVA PF05103.8 KII68584.1 - 1.9 8.5 11.7 12 5.9 7.9 2.1 1 1 0 1 1 1 0 DivIVA protein Arc_PepC_II PF06847.6 KII68584.1 - 2.2 8.7 6.5 10 6.6 1.1 2.1 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II KLRAQ PF10205.4 KII68584.1 - 2.4 8.2 9.2 6.1 6.9 0.2 2.6 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Syntaxin-6_N PF09177.6 KII68584.1 - 3.1 8.2 9.4 30 5.1 4.9 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CorA PF01544.13 KII68584.1 - 3.4 6.5 6.8 5.4 5.9 4.7 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein ASD2 PF08687.6 KII68584.1 - 3.5 6.8 11.4 4 6.6 6.1 1.8 1 1 1 2 2 2 0 Apx/Shroom domain ASD2 DUF3450 PF11932.3 KII68584.1 - 4 6.6 11.6 2 7.5 3.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF972 PF06156.8 KII68584.1 - 4 7.8 10.4 19 5.6 5.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF1664 PF07889.7 KII68584.1 - 5 6.9 8.6 15 5.3 4.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Zein-binding PF04576.10 KII68584.1 - 5.1 7.2 9.4 0.69 10.0 2.1 2.2 2 1 0 2 2 2 0 Zein-binding DUF641 PF04859.7 KII68584.1 - 5.1 6.8 9.5 2.2 8.0 1.2 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) RTBV_P46 PF06216.6 KII68584.1 - 5.6 5.7 10.6 2.7 6.7 0.6 2.0 1 1 1 2 2 2 0 Rice tungro bacilliform virus P46 protein Syntaxin PF00804.20 KII68584.1 - 6.4 6.9 16.3 12 6.0 9.1 2.3 1 1 1 2 2 2 0 Syntaxin Phage_GP20 PF06810.6 KII68584.1 - 9.9 5.5 14.4 1.7e+02 1.5 10.0 2.3 1 1 0 1 1 1 0 Phage minor structural protein GP20 Lebercilin PF15619.1 KII68585.1 - 0.0033 16.8 7.0 0.0045 16.4 4.8 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Vir_act_alpha_C PF10400.4 KII68585.1 - 0.01 16.1 1.1 0.01 16.1 0.8 1.8 1 1 1 2 2 2 0 Virulence activator alpha C-term GAS PF13851.1 KII68585.1 - 0.063 12.4 14.6 0.59 9.2 2.9 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Peptidase_M57 PF12388.3 KII68585.1 - 0.076 12.3 1.1 0.091 12.0 0.8 1.1 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Bap31 PF05529.7 KII68585.1 - 0.1 12.0 8.5 1.1 8.6 2.1 2.1 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like AAA_13 PF13166.1 KII68585.1 - 0.12 10.7 11.5 0.14 10.6 7.9 1.1 1 0 0 1 1 1 0 AAA domain DUF3972 PF13118.1 KII68585.1 - 0.12 12.4 8.3 0.094 12.8 3.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3972) CSTF_C PF14304.1 KII68585.1 - 0.15 11.3 2.2 13 5.1 0.1 2.8 2 1 0 2 2 2 0 Transcription termination and cleavage factor C-terminal Kinetocho_Slk19 PF12709.2 KII68585.1 - 0.15 12.1 8.1 0.15 12.1 0.6 2.8 1 1 1 3 3 3 0 Central kinetochore-associated Reo_sigmaC PF04582.7 KII68585.1 - 0.26 10.4 1.4 0.3 10.2 0.9 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Tropomyosin_1 PF12718.2 KII68585.1 - 0.28 11.0 9.2 1.7 8.4 1.6 2.1 1 1 1 2 2 2 0 Tropomyosin like TMF_TATA_bd PF12325.3 KII68585.1 - 0.39 10.4 8.9 1.7 8.4 1.5 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding PspA_IM30 PF04012.7 KII68585.1 - 0.41 9.9 8.3 3.9 6.7 0.2 2.0 1 1 1 2 2 2 0 PspA/IM30 family Fib_alpha PF08702.5 KII68585.1 - 0.48 10.5 11.8 1.2 9.2 8.1 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DivIC PF04977.10 KII68585.1 - 0.52 9.8 10.2 0.1 12.1 1.0 2.7 1 1 0 2 2 2 0 Septum formation initiator Spc7 PF08317.6 KII68585.1 - 0.67 8.5 12.4 1.5 7.4 8.6 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Med9 PF07544.8 KII68585.1 - 1 9.1 6.9 0.43 10.3 2.0 2.4 1 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 IncA PF04156.9 KII68585.1 - 1.1 8.8 10.8 32 4.0 7.5 2.0 1 1 0 1 1 1 0 IncA protein DUF724 PF05266.9 KII68585.1 - 1.2 8.7 8.2 2.4 7.7 5.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF342 PF03961.8 KII68585.1 - 1.9 6.7 9.9 0.52 8.6 2.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DUF4200 PF13863.1 KII68585.1 - 2.6 7.9 13.4 6.8 6.6 4.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) TMF_DNA_bd PF12329.3 KII68585.1 - 2.8 7.8 12.6 6.3 6.6 2.7 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding PRD PF00874.15 KII68590.1 - 0.0054 16.8 1.7 0.13 12.3 0.1 2.1 1 1 1 2 2 2 2 PRD domain TAF4 PF05236.9 KII68592.1 - 0.00094 18.5 12.4 0.0012 18.1 8.6 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Microtub_bind PF13931.1 KII68592.1 - 0.17 12.0 10.9 0.19 11.8 1.2 2.1 2 0 0 2 2 2 0 Kinesin-associated microtubule-binding DUF2363 PF10155.4 KII68593.1 - 0.025 14.5 0.6 0.044 13.7 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2363) Sororin PF09666.5 KII68595.1 - 0.012 15.8 0.6 0.024 14.8 0.4 1.6 1 0 0 1 1 1 0 Sororin protein ISAV_HA PF06215.6 KII68595.1 - 0.034 12.4 0.0 0.041 12.1 0.0 1.2 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin Guanylate_cyc PF00211.15 KII68595.1 - 0.057 12.7 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain SNAP PF14938.1 KII68596.1 - 2.3e-06 26.9 0.2 2.9e-06 26.6 0.2 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Pox_T4_C PF04490.7 KII68596.1 - 0.041 13.6 0.7 0.055 13.2 0.5 1.2 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus efb-c PF12199.3 KII68596.1 - 0.087 12.6 0.1 0.33 10.8 0.0 1.9 2 0 0 2 2 2 0 Extracellular fibrinogen binding protein C terminal EF_TS PF00889.14 KII68597.1 - 0.00042 19.6 1.8 0.00042 19.6 1.2 1.7 2 0 0 2 2 2 1 Elongation factor TS DsrC PF04358.8 KII68597.1 - 0.0061 16.7 0.4 0.0095 16.1 0.2 1.3 1 1 0 1 1 1 1 DsrC like protein Lipoprotein_Ltp PF07553.6 KII68597.1 - 0.014 15.2 0.1 0.037 13.9 0.1 1.7 1 0 0 1 1 1 0 Host cell surface-exposed lipoprotein XH PF03469.9 KII68597.1 - 0.026 14.1 1.4 0.044 13.4 0.3 1.9 1 1 1 2 2 2 0 XH domain ISG65-75 PF11727.3 KII68597.1 - 0.049 12.6 3.9 0.054 12.5 2.7 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein SapB_1 PF05184.10 KII68597.1 - 0.21 11.4 0.1 0.21 11.4 0.1 2.4 3 0 0 3 3 3 0 Saposin-like type B, region 1 COMPASS-Shg1 PF05205.7 KII68597.1 - 2.2 8.6 7.1 11 6.4 1.9 2.2 1 1 1 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 P12 PF12669.2 KII68598.1 - 0.047 13.8 0.2 0.077 13.2 0.1 1.3 1 0 0 1 1 1 0 Virus attachment protein p12 family DDE_3 PF13358.1 KII68600.1 - 3.9e-21 75.3 0.0 6.4e-21 74.6 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF4371 PF14291.1 KII68601.1 - 0.00016 21.3 0.1 0.00019 21.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DNase-RNase PF02577.9 KII68603.1 - 0.097 11.8 0.0 0.15 11.3 0.0 1.5 1 1 0 1 1 1 0 Bifunctional nuclease SPX PF03105.14 KII68603.1 - 0.14 11.9 0.5 0.19 11.5 0.4 1.2 1 0 0 1 1 1 0 SPX domain Tetraspannin PF00335.15 KII68604.1 - 1.6e-09 37.3 19.0 2.9e-09 36.5 13.2 1.4 1 1 0 1 1 1 1 Tetraspanin family DUF3938 PF13074.1 KII68604.1 - 0.054 13.3 3.1 0.12 12.2 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3938) DUF3154 PF11351.3 KII68604.1 - 0.078 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3154) ABC2_membrane_2 PF12679.2 KII68604.1 - 0.16 10.8 4.4 0.24 10.2 3.1 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein Claudin_2 PF13903.1 KII68604.1 - 1.6 8.4 13.5 28 4.3 0.0 2.4 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF3810 PF12725.2 KII68604.1 - 1.8 7.4 6.8 2.6 6.8 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) zf-C2H2 PF00096.21 KII68605.1 - 2.7e-06 27.4 1.9 0.0021 18.2 0.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KII68605.1 - 5.3e-06 26.4 1.1 0.2 12.0 0.0 2.7 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_6 PF13912.1 KII68605.1 - 1.7e-05 24.5 1.4 0.00016 21.4 0.1 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.1 KII68605.1 - 9.2e-05 22.5 6.5 0.0011 19.2 0.1 2.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII68605.1 - 0.00021 21.3 2.5 0.0012 18.9 0.1 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Sec23_Sec24 PF04810.10 KII68605.1 - 0.0034 16.8 4.9 0.0085 15.6 1.2 2.7 2 1 0 2 2 2 1 Sec23/Sec24 zinc finger zf-met PF12874.2 KII68605.1 - 0.0073 16.4 3.1 0.39 10.9 0.0 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 KII68605.1 - 0.11 12.6 5.6 0.19 11.8 2.2 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.7 KII68605.1 - 0.2 11.3 2.4 5.9 6.6 0.1 2.3 2 0 0 2 2 2 0 DBF zinc finger C1_2 PF03107.11 KII68605.1 - 0.35 11.0 0.3 0.35 11.0 0.2 3.2 4 0 0 4 4 3 0 C1 domain zf-C2HC_2 PF13913.1 KII68605.1 - 0.87 9.3 4.7 0.67 9.6 0.4 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type EGF_CA PF07645.10 KII68605.1 - 2.3 8.2 7.4 35 4.5 0.1 3.4 4 0 0 4 4 4 0 Calcium-binding EGF domain C1_4 PF07975.7 KII68605.1 - 3.5 7.6 6.8 3.6 7.6 1.6 2.5 1 1 1 2 2 2 0 TFIIH C1-like domain DUF4358 PF14270.1 KII68606.1 - 0.034 14.0 1.0 0.1 12.5 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) SBP PF03110.9 KII68606.1 - 0.093 12.9 0.5 0.19 11.9 0.4 1.4 1 0 0 1 1 1 0 SBP domain DUF3884 PF13024.1 KII68609.1 - 3.2e-05 23.2 0.0 4.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3884) MCM_bind PF09739.4 KII68613.1 - 0.11 12.0 0.2 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DDE_3 PF13358.1 KII68615.1 - 5.5e-14 52.1 0.0 7.6e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Flavodoxin_NdrI PF07972.6 KII68615.1 - 0.11 12.4 0.1 0.5 10.2 0.1 1.9 2 0 0 2 2 2 0 NrdI Flavodoxin like Integrin_beta PF00362.13 KII68617.1 - 7e-11 41.6 0.0 8.5e-11 41.3 0.0 1.0 1 0 0 1 1 1 1 Integrin, beta chain CENP-B_dimeris PF09026.5 KII68619.1 - 0.027 14.7 3.2 0.041 14.1 2.2 1.4 1 1 0 1 1 1 0 Centromere protein B dimerisation domain zf-UBR PF02207.15 KII68620.1 - 9.9e-12 44.4 14.9 3.3e-11 42.7 10.3 2.0 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) rve PF00665.21 KII68623.1 - 4.8e-07 29.9 0.0 5.8e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII68625.1 - 4e-06 26.4 15.7 5.4e-05 22.9 2.0 2.2 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.1 KII68625.1 - 0.019 14.4 15.7 0.052 13.0 1.9 2.3 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-C4pol PF14260.1 KII68625.1 - 0.083 12.9 7.7 0.45 10.5 1.5 2.2 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta YhfH PF14149.1 KII68625.1 - 0.11 12.2 8.3 0.22 11.3 5.8 1.5 1 0 0 1 1 1 0 YhfH-like protein zf-CCHC_4 PF14392.1 KII68625.1 - 0.25 11.0 9.2 0.86 9.3 0.4 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 KII68625.1 - 1.1 9.0 17.7 0.18 11.5 3.0 2.9 2 1 1 3 3 3 0 Zinc knuckle DUF629 PF04780.7 KII68625.1 - 2.2 6.7 10.8 0.95 7.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF629) Tn7_Tnp_TnsA_C PF08721.6 KII68626.1 - 0.037 14.0 0.2 0.089 12.8 0.1 1.6 2 0 0 2 2 2 0 TnsA endonuclease C terminal DUF3130 PF11328.3 KII68626.1 - 0.039 14.0 0.0 0.055 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3130 rve PF00665.21 KII68627.1 - 5.7e-05 23.2 0.0 0.00012 22.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII68627.1 - 0.0065 15.9 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DUF3293 PF11697.3 KII68627.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3293) RVT_1 PF00078.22 KII68629.1 - 4.7e-19 68.5 0.0 5.5e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF815 PF05673.8 KII68629.1 - 0.04 12.8 0.0 0.056 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Arg_repressor_C PF02863.13 KII68629.1 - 0.05 13.0 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain Spc7_N PF15402.1 KII68632.1 - 0.063 11.2 0.0 0.069 11.1 0.0 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 KH_1 PF00013.24 KII68634.1 - 4.2e-16 58.3 5.7 1.4e-07 31.0 0.0 6.6 7 0 0 7 7 7 3 KH domain SLS PF14611.1 KII68634.1 - 6.8e-05 22.3 0.6 0.51 9.7 0.0 3.5 3 1 1 4 4 4 2 Mitochondrial inner-membrane-bound regulator KH_3 PF13014.1 KII68634.1 - 0.00029 20.4 6.5 0.0033 17.0 0.0 4.7 6 0 0 6 6 6 1 KH domain DUF2067 PF09840.4 KII68634.1 - 0.0067 15.9 1.0 0.1 12.1 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized protein conserved in archaea (DUF2067) NEP PF10167.4 KII68634.1 - 0.008 15.8 3.7 0.052 13.2 0.2 2.7 2 0 0 2 2 2 1 Uncharacterised conserved protein Phage_portal PF04860.7 KII68634.1 - 0.021 13.5 0.3 0.95 8.0 0.0 2.3 2 0 0 2 2 2 0 Phage portal protein zf-BED PF02892.10 KII68636.1 - 7.7e-05 22.3 0.2 0.00018 21.1 0.1 1.6 1 0 0 1 1 1 1 BED zinc finger Sec34 PF04136.10 KII68636.1 - 0.14 11.8 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Sec34-like family rve PF00665.21 KII68637.1 - 1.1e-29 102.9 0.0 3.5e-29 101.3 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII68637.1 - 1.2e-25 90.1 0.1 2.5e-25 89.0 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII68637.1 - 9.1e-06 25.5 0.1 2.4e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII68637.1 - 1.3e-05 24.7 0.0 4.3e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.18 KII68637.1 - 8.3e-05 22.3 10.1 0.017 15.0 1.6 2.8 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII68637.1 - 0.001 19.4 0.0 0.0027 18.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII68637.1 - 0.0011 18.7 0.0 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.1 KII68637.1 - 0.002 17.6 0.0 0.0069 15.8 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.6 KII68637.1 - 0.0026 17.7 0.4 0.0062 16.4 0.3 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII68637.1 - 0.33 10.7 13.1 41 4.0 9.1 2.8 1 1 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.1 KII68637.1 - 0.42 10.3 14.1 0.12 12.0 1.9 2.6 2 0 0 2 2 2 0 Zinc knuckle adh_short PF00106.20 KII68640.1 - 1.3e-26 93.4 0.0 2.1e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KII68640.1 - 2.8e-13 50.2 0.3 4e-13 49.7 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KII68640.1 - 1.4e-11 44.4 0.0 1.9e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 KII68640.1 - 0.00015 21.4 1.2 0.00015 21.4 0.9 2.3 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.14 KII68640.1 - 0.00036 19.6 0.0 0.0008 18.5 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.1 KII68640.1 - 0.0008 19.4 2.0 0.0097 15.9 0.2 2.4 2 1 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 KII68640.1 - 0.006 16.0 0.0 0.0089 15.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 KII68640.1 - 0.012 15.3 0.1 0.018 14.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 KII68640.1 - 0.03 14.5 0.3 0.054 13.7 0.2 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Lon_C PF05362.8 KII68640.1 - 0.045 13.0 0.1 0.074 12.3 0.1 1.3 1 0 0 1 1 1 0 Lon protease (S16) C-terminal proteolytic domain Shikimate_DH PF01488.15 KII68640.1 - 0.1 12.7 0.5 0.2 11.7 0.3 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ribosomal_S30AE PF02482.14 KII68642.1 - 0.075 13.4 1.4 0.42 11.0 0.1 2.3 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein APOC4 PF15119.1 KII68642.1 - 0.11 12.5 0.0 12 5.9 0.0 2.5 2 0 0 2 2 2 0 Apolipoprotein C4 Ribosomal_L6 PF00347.18 KII68643.1 - 4.9e-20 71.8 3.6 1.5e-12 47.7 0.2 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Sec10 PF07393.6 KII68645.1 - 2e-11 42.8 0.6 2.4e-11 42.5 0.4 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF1682 PF07946.9 KII68646.1 - 5.2e-05 22.2 26.0 0.021 13.6 14.8 3.0 1 1 1 2 2 2 2 Protein of unknown function (DUF1682) UPF0242 PF06785.6 KII68646.1 - 4 5.9 9.6 7.4 5.1 6.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) SR-25 PF10500.4 KII68646.1 - 7.5 5.9 16.2 23 4.3 9.2 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein E1_DerP2_DerF2 PF02221.10 KII68647.1 - 0.00058 20.1 0.0 0.00071 19.8 0.0 1.1 1 0 0 1 1 1 1 ML domain PSI_PsaJ PF01701.13 KII68647.1 - 0.06 13.1 1.7 0.11 12.3 1.2 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ EF-hand_7 PF13499.1 KII68649.1 - 0.061 13.4 0.1 0.24 11.5 0.1 1.9 2 0 0 2 2 2 0 EF-hand domain pair Tctex-1 PF03645.8 KII68649.1 - 0.069 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Tctex-1 family Peptidase_M28 PF04389.12 KII68650.1 - 2.7e-37 128.2 0.0 3.6e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 KAP_NTPase PF07693.9 KII68651.1 - 0.15 11.0 0.0 0.25 10.3 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain DUF3321 PF11968.3 KII68652.1 - 0.063 12.8 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase (DUF3321) Rep-A_N PF04057.7 KII68652.1 - 0.13 12.0 0.1 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain DUF1198 PF06711.6 KII68654.1 - 0.15 11.8 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) Glyco_transf_25 PF01755.12 KII68655.1 - 9.7e-23 80.8 0.4 4.3e-22 78.7 0.3 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Caudo_TAP PF02413.12 KII68656.1 - 3.9e-23 82.0 0.8 4.7e-23 81.7 0.6 1.1 1 0 0 1 1 1 1 Caudovirales tail fibre assembly protein gp37_C PF12604.3 KII68657.1 - 4.2e-05 23.3 4.1 4.2e-05 23.3 2.9 1.6 1 1 1 2 2 2 1 Tail fiber protein gp37 C terminal Lgl_C PF08596.5 KII68660.1 - 0.058 11.8 0.0 0.07 11.5 0.0 1.0 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal RVT_1 PF00078.22 KII68661.1 - 2.3e-10 40.2 0.5 3.9e-10 39.4 0.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YbjN PF10722.4 KII68661.1 - 0.051 13.6 0.0 3.5 7.6 0.0 2.1 2 0 0 2 2 2 0 Putative bacterial sensory transduction regulator DUF2018 PF09442.5 KII68661.1 - 0.054 14.0 0.2 0.17 12.5 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2018) Ph1570 PF09638.5 KII68661.1 - 0.062 13.1 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Ph1570 protein zf-CCHC PF00098.18 KII68662.1 - 2.2e-05 24.1 4.0 2.2e-05 24.1 2.8 1.7 2 0 0 2 2 2 1 Zinc knuckle DUF1554 PF07588.6 KII68662.1 - 0.0099 15.3 0.0 0.013 15.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1554) AKNA PF12443.3 KII68662.1 - 0.013 15.5 0.8 0.027 14.4 0.5 1.5 1 0 0 1 1 1 0 AT-hook-containing transcription factor Phasin PF05597.6 KII68662.1 - 0.03 14.0 0.3 0.054 13.2 0.1 1.6 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) TSC22 PF01166.13 KII68662.1 - 0.046 13.7 0.5 0.14 12.1 0.3 1.8 1 0 0 1 1 1 0 TSC-22/dip/bun family Myb_DNA-bind_5 PF13873.1 KII68662.1 - 0.08 12.8 0.4 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain UBN2 PF14223.1 KII68662.1 - 0.089 12.5 0.7 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type zf-CCHC_4 PF14392.1 KII68662.1 - 0.09 12.4 1.1 0.18 11.4 0.8 1.5 1 0 0 1 1 1 0 Zinc knuckle Syntaxin-6_N PF09177.6 KII68662.1 - 0.098 13.0 0.6 0.16 12.3 0.1 1.6 2 0 0 2 2 2 0 Syntaxin 6, N-terminal ATP-synt_B PF00430.13 KII68662.1 - 0.18 11.5 2.4 0.64 9.8 0.4 2.0 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) Pox_A_type_inc PF04508.7 KII68662.1 - 0.19 11.6 3.6 0.44 10.4 2.5 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat MbeD_MobD PF04899.7 KII68662.1 - 0.34 10.8 1.8 0.37 10.7 0.4 1.8 2 1 0 2 2 2 0 MbeD/MobD like Atg14 PF10186.4 KII68662.1 - 1.1 8.1 4.5 2.3 7.0 2.0 1.8 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 MSP7_C PF12948.2 KII68663.1 - 0.0012 19.0 0.2 0.037 14.2 0.0 2.2 2 0 0 2 2 2 2 MSP7-like protein C-terminal domain Peptidase_C50 PF03568.12 KII68666.1 - 0.064 11.9 0.2 0.065 11.9 0.1 1.0 1 0 0 1 1 1 0 Peptidase family C50 DUF1629 PF07791.6 KII68668.1 - 0.077 12.8 0.0 6 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1629) TetR_C_8 PF14278.1 KII68672.1 - 0.42 11.0 4.3 22 5.5 0.1 3.5 4 0 0 4 4 4 0 Transcriptional regulator C-terminal region PI-PLC-X PF00388.14 KII68674.1 - 0.19 11.1 1.8 0.2 11.0 0.2 1.8 2 0 0 2 2 2 0 Phosphatidylinositol-specific phospholipase C, X domain DUF3441 PF11923.3 KII68681.1 - 6.1e-25 87.0 0.0 6.1e-25 87.0 0.0 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3441) DUF814 PF05670.8 KII68681.1 - 4.2e-24 84.2 1.5 9.2e-24 83.1 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF814) V-set PF07686.12 KII68682.1 - 1.8 8.4 5.8 0.44 10.4 0.1 2.9 3 2 0 3 3 3 0 Immunoglobulin V-set domain Noc2 PF03715.8 KII68683.1 - 3.3e-46 157.5 6.4 3.3e-46 157.5 4.5 1.8 2 0 0 2 2 2 1 Noc2p family Isochorismatase PF00857.15 KII68685.1 - 3.8e-14 52.9 0.3 4.2e-14 52.8 0.2 1.1 1 0 0 1 1 1 1 Isochorismatase family RRM_1 PF00076.17 KII68686.1 - 4.6e-14 51.8 0.0 7.5e-14 51.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII68686.1 - 3.5e-10 39.7 0.0 5.9e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII68686.1 - 9.1e-08 31.8 0.0 1.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 KII68686.1 - 2.3e-05 24.7 1.3 2.3e-05 24.7 0.9 2.8 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 Myb_DNA-bind_6 PF13921.1 KII68688.1 - 1.7e-11 44.0 0.2 6.8e-05 22.8 0.0 2.6 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KII68688.1 - 1.6e-10 40.8 2.6 0.0003 20.7 0.0 2.6 2 1 0 2 2 2 2 Myb-like DNA-binding domain DDE_3 PF13358.1 KII68689.1 - 2.9e-10 40.0 0.1 3.2e-10 39.9 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Dynamin_M PF01031.15 KII68689.1 - 0.0097 14.7 0.1 0.012 14.4 0.1 1.1 1 0 0 1 1 1 1 Dynamin central region Myb_DNA-bind_6 PF13921.1 KII68690.1 - 2.2e-09 37.2 4.9 7.3e-07 29.2 0.1 3.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KII68690.1 - 3.8e-07 30.0 1.6 0.00014 21.8 0.1 3.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Asp_Glu_race_2 PF14669.1 KII68690.1 - 0.0057 16.0 0.1 0.009 15.3 0.1 1.3 1 0 0 1 1 1 1 Putative aspartate racemase DUF445 PF04286.7 KII68690.1 - 0.026 14.0 0.6 0.031 13.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF1566 PF07603.6 KII68690.1 - 0.064 12.9 0.5 0.12 12.0 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1566) AAA_5 PF07728.9 KII68692.1 - 1.3e-109 361.8 0.0 3.1e-24 85.2 0.0 9.0 9 0 0 9 9 8 8 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KII68692.1 - 5.2e-34 116.6 0.0 1.1e-13 50.8 0.0 6.6 7 0 0 7 7 6 3 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 KII68692.1 - 5.9e-17 62.0 1.9 0.021 15.0 0.0 7.1 7 0 0 7 7 6 4 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KII68692.1 - 1.8e-14 53.9 2.5 0.0011 19.0 0.0 6.6 5 1 0 5 5 4 3 AAA domain AAA_16 PF13191.1 KII68692.1 - 2.2e-14 53.8 0.1 0.0023 17.9 0.0 5.8 5 0 0 5 5 5 4 AAA ATPase domain ABC_tran PF00005.22 KII68692.1 - 1.3e-11 44.9 1.0 0.0034 17.6 0.0 7.3 7 0 0 7 7 6 2 ABC transporter Sigma54_activat PF00158.21 KII68692.1 - 1.7e-10 40.5 0.0 0.46 9.9 0.0 5.3 5 0 0 5 5 5 3 Sigma-54 interaction domain AAA_17 PF13207.1 KII68692.1 - 2.6e-10 41.1 0.8 3.9 8.3 0.0 6.9 5 0 0 5 5 5 1 AAA domain Sigma54_activ_2 PF14532.1 KII68692.1 - 5e-09 36.3 0.0 0.17 11.9 0.0 5.0 4 0 0 4 4 4 2 Sigma-54 interaction domain UPF0079 PF02367.12 KII68692.1 - 5.3e-09 35.7 0.2 0.039 13.5 0.0 5.7 6 0 0 6 6 5 2 Uncharacterised P-loop hydrolase UPF0079 AAA_19 PF13245.1 KII68692.1 - 6.6e-08 32.1 0.3 0.021 14.5 0.0 4.0 4 0 0 4 4 3 2 Part of AAA domain AAA_33 PF13671.1 KII68692.1 - 2.4e-07 30.7 0.0 1.1 9.1 0.0 5.0 4 1 0 4 4 4 2 AAA domain T2SE PF00437.15 KII68692.1 - 2.9e-07 29.6 0.2 3 6.6 0.0 5.9 5 0 0 5 5 5 2 Type II/IV secretion system protein MobB PF03205.9 KII68692.1 - 1.4e-06 28.0 2.3 0.054 13.2 0.0 4.4 5 0 0 5 5 3 2 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.16 KII68692.1 - 4.8e-06 25.8 0.0 1.5 7.9 0.0 5.2 5 1 0 5 5 5 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 KII68692.1 - 5.2e-06 26.7 10.9 0.97 9.7 0.0 7.0 6 0 0 6 6 5 2 AAA domain PduV-EutP PF10662.4 KII68692.1 - 6.7e-06 25.6 0.6 0.46 9.9 0.0 4.4 5 0 0 5 5 4 2 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 KII68692.1 - 7.2e-06 25.7 0.4 0.63 9.6 0.0 4.6 4 0 0 4 4 4 2 NACHT domain Zeta_toxin PF06414.7 KII68692.1 - 1.7e-05 23.9 0.2 3 6.9 0.0 5.5 5 0 0 5 5 5 1 Zeta toxin Miro PF08477.8 KII68692.1 - 2.7e-05 24.6 3.5 1.4 9.4 0.0 5.1 4 0 0 4 4 3 2 Miro-like protein RNA_helicase PF00910.17 KII68692.1 - 2.8e-05 24.2 2.6 7.4 6.7 0.0 6.5 6 0 0 6 6 6 0 RNA helicase AAA_29 PF13555.1 KII68692.1 - 4.7e-05 22.8 2.4 1.9 8.0 0.0 4.9 5 0 0 5 5 4 2 P-loop containing region of AAA domain AAA_25 PF13481.1 KII68692.1 - 0.00017 21.0 0.2 4.2 6.7 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA_28 PF13521.1 KII68692.1 - 0.00045 20.2 4.1 9 6.2 0.0 5.3 5 0 0 5 5 5 0 AAA domain AAA_30 PF13604.1 KII68692.1 - 0.0017 17.9 0.0 7.2 6.1 0.0 4.4 5 0 0 5 5 4 0 AAA domain SRP54 PF00448.17 KII68692.1 - 0.0025 17.3 0.0 7.4 5.9 0.0 3.5 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain RuvB_N PF05496.7 KII68692.1 - 0.0041 16.2 2.6 4.2 6.3 0.0 5.0 6 0 0 6 6 6 1 Holliday junction DNA helicase ruvB N-terminus VWA_3 PF13768.1 KII68692.1 - 0.038 13.6 0.1 0.34 10.6 0.0 2.3 2 0 0 2 2 2 0 von Willebrand factor type A domain CPT PF07931.7 KII68692.1 - 0.048 13.2 0.1 34 3.9 0.0 4.1 3 1 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein ATP-synt_ab PF00006.20 KII68692.1 - 0.12 11.9 0.0 1.1e+02 2.1 0.0 4.1 5 0 0 5 5 5 0 ATP synthase alpha/beta family, nucleotide-binding domain DDE_3 PF13358.1 KII68698.1 - 2.6e-28 98.6 0.0 3.1e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII68698.1 - 0.0027 17.7 0.0 0.0043 17.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Colicin_Pyocin PF01320.13 KII68698.1 - 0.0044 16.8 0.0 0.0085 15.9 0.0 1.5 1 0 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein DDE_1 PF03184.14 KII68698.1 - 0.012 14.7 0.0 0.06 12.4 0.0 1.8 1 1 1 2 2 2 0 DDE superfamily endonuclease Rad51 PF08423.6 KII68699.1 - 0.036 12.9 0.0 0.04 12.8 0.0 1.2 1 0 0 1 1 1 0 Rad51 PX PF00787.19 KII68700.1 - 0.00027 20.6 0.0 0.00041 20.1 0.0 1.3 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 KII68701.1 - 3.6e-08 32.9 2.4 1e-07 31.5 1.7 1.8 1 1 0 1 1 1 1 Vps5 C terminal like BAR_3_WASP_bdg PF10456.4 KII68701.1 - 0.00015 21.1 1.4 0.00018 20.8 1.0 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein ELMO_CED12 PF04727.8 KII68702.1 - 2.6e-13 49.8 0.0 4.6e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family Fork_head PF00250.13 KII68702.1 - 3.1 7.9 6.0 2.4 8.2 0.9 2.6 2 1 1 3 3 3 0 Fork head domain HAP1_N PF04849.8 KII68703.1 - 0.0003 19.8 1.8 0.0003 19.8 1.2 1.4 2 0 0 2 2 2 1 HAP1 N-terminal conserved region zf-Apc11 PF12861.2 KII68703.1 - 0.015 15.1 2.8 0.022 14.6 2.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1910 PF08928.5 KII68703.1 - 0.019 14.9 0.4 0.035 14.1 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1910) zf-C3HC4_2 PF13923.1 KII68703.1 - 0.033 14.2 10.5 0.086 12.8 7.3 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Paramyx_P_V_C PF03210.8 KII68703.1 - 0.041 13.7 0.5 0.062 13.1 0.3 1.2 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal zf-Nse PF11789.3 KII68703.1 - 0.051 13.1 4.4 0.12 11.9 3.0 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.1 KII68703.1 - 0.16 11.8 14.7 0.42 10.4 10.2 1.7 1 1 0 1 1 1 0 Ring finger domain Prok-RING_1 PF14446.1 KII68703.1 - 0.24 11.1 11.2 0.16 11.7 5.8 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 BLOC1_2 PF10046.4 KII68703.1 - 0.49 10.5 6.6 0.29 11.2 2.2 2.1 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-rbx1 PF12678.2 KII68703.1 - 2.3 8.4 12.4 6.6 6.9 8.5 2.0 1 1 1 2 2 2 0 RING-H2 zinc finger zf-C3HC4 PF00097.20 KII68703.1 - 9.6 5.9 11.9 40 3.9 8.4 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Clathrin PF00637.15 KII68704.1 - 2.9e-16 59.3 14.6 9.6e-11 41.4 1.4 2.9 1 1 1 3 3 3 2 Region in Clathrin and VPS Leuk-A4-hydro_C PF09127.6 KII68704.1 - 0.19 11.2 1.2 0.85 9.2 0.0 2.3 2 1 0 2 2 2 0 Leukotriene A4 hydrolase, C-terminal VHP PF02209.14 KII68706.1 - 3.3e-09 36.2 6.7 3.3e-09 36.2 4.6 3.3 3 0 0 3 3 3 1 Villin headpiece domain Gelsolin PF00626.17 KII68706.1 - 0.00038 20.0 2.9 0.46 10.2 0.0 3.6 3 1 0 3 3 3 2 Gelsolin repeat SKIP_SNW PF02731.10 KII68707.1 - 4.4e-53 178.9 1.3 4.4e-53 178.9 0.9 2.6 3 0 0 3 3 3 2 SKIP/SNW domain HSP70 PF00012.15 KII68707.1 - 3.8 5.2 7.9 0.75 7.6 3.2 1.4 2 0 0 2 2 2 0 Hsp70 protein FTO_CTD PF12934.2 KII68708.1 - 0.002 17.7 0.4 0.0024 17.4 0.3 1.1 1 0 0 1 1 1 1 FTO C-terminal domain CENP-K PF11802.3 KII68708.1 - 0.0053 16.0 1.0 0.0061 15.8 0.7 1.1 1 0 0 1 1 1 1 Centromere-associated protein K Rabaptin PF03528.10 KII68708.1 - 0.0068 16.2 1.7 0.0092 15.8 1.2 1.1 1 0 0 1 1 1 1 Rabaptin SRA1 PF07304.6 KII68708.1 - 0.0092 15.7 0.2 0.011 15.5 0.1 1.1 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) Peptidase_M75 PF09375.5 KII68708.1 - 0.028 13.7 0.3 0.031 13.5 0.2 1.1 1 0 0 1 1 1 0 Imelysin GA PF01468.12 KII68708.1 - 0.037 14.1 2.6 0.056 13.5 1.8 1.3 1 0 0 1 1 1 0 GA module Iron_permease PF04120.7 KII68708.1 - 0.058 12.9 1.7 0.07 12.7 1.2 1.1 1 0 0 1 1 1 0 Low affinity iron permease PhoU PF01895.14 KII68708.1 - 0.062 13.7 0.5 0.093 13.1 0.3 1.4 1 1 0 1 1 1 0 PhoU domain Tnp_P_element_C PF12596.3 KII68708.1 - 0.088 13.1 1.0 0.12 12.7 0.7 1.2 1 0 0 1 1 1 0 87kDa Transposase Cytadhesin_P30 PF07271.6 KII68708.1 - 0.094 11.9 1.6 0.12 11.6 1.1 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 DDE_3 PF13358.1 KII68709.1 - 2.8e-14 53.0 0.0 4.2e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 KII68709.1 - 0.003 17.1 0.0 0.018 14.6 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII68709.1 - 0.0051 16.9 0.0 0.0083 16.2 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix DUF1323 PF07037.6 KII68709.1 - 0.0055 16.8 0.0 0.0098 16.0 0.0 1.4 1 0 0 1 1 1 1 Putative transcription regulator (DUF1323) EGF_2 PF07974.8 KII68711.1 - 5.4e-08 32.8 35.4 2.7e-06 27.4 12.6 2.8 2 0 0 2 2 2 2 EGF-like domain Integrin_beta PF00362.13 KII68712.1 - 2.6e-09 36.4 0.5 8.8e-06 24.8 0.0 2.0 1 1 1 2 2 2 2 Integrin, beta chain DUF1374 PF07118.6 KII68712.1 - 0.052 13.6 1.2 0.57 10.3 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1374) MotA_activ PF09114.5 KII68712.1 - 0.078 12.7 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Transcription factor MotA, activation domain BAR PF03114.13 KII68713.1 - 2.7e-07 30.3 0.0 3.1e-07 30.1 0.0 1.0 1 0 0 1 1 1 1 BAR domain DUF4319 PF14203.1 KII68713.1 - 0.0068 15.9 0.3 0.02 14.4 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4319) adh_short_C2 PF13561.1 KII68713.1 - 0.015 15.1 0.3 0.021 14.6 0.1 1.4 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase PRANC PF09372.5 KII68713.1 - 0.11 12.4 2.9 3.5 7.6 0.1 2.2 1 1 1 2 2 2 0 PRANC domain DUF3713 PF12506.3 KII68713.1 - 2.7 8.1 5.3 6.7 6.8 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3713) RVT_1 PF00078.22 KII68714.1 - 1.8e-27 96.1 0.2 4e-26 91.6 0.0 2.9 3 1 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII68714.1 - 7.9e-11 41.7 0.0 2.8e-10 39.9 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII68714.1 - 1.4e-07 31.9 0.2 3.3e-07 30.7 0.2 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII68714.1 - 2.7e-06 27.1 0.0 4.9e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII68714.1 - 8.6e-06 25.4 1.6 1.9e-05 24.3 1.1 1.6 1 0 0 1 1 1 1 Zinc knuckle Peptidase_A3 PF02160.10 KII68714.1 - 0.00011 21.8 0.8 0.00011 21.8 0.6 1.9 2 0 0 2 2 2 1 Cauliflower mosaic virus peptidase (A3) Asp_protease PF09668.5 KII68714.1 - 0.0028 17.2 0.0 0.0063 16.0 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease DNA_pol3_a_NII PF11490.3 KII68714.1 - 0.016 14.8 1.0 0.016 14.8 0.7 2.4 3 0 0 3 3 3 0 DNA polymerase III polC-type N-terminus II DUF4094 PF13334.1 KII68714.1 - 0.027 14.8 0.6 0.062 13.6 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF4509 PF14970.1 KII68714.1 - 0.028 14.0 1.5 0.049 13.2 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4509) Spuma_A9PTase PF03539.9 KII68714.1 - 0.028 14.3 0.0 0.075 12.9 0.0 1.8 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) DDE_3 PF13358.1 KII68715.1 - 9.5e-22 77.3 0.2 1.1e-21 77.1 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease XFP PF03894.10 KII68715.1 - 0.0065 16.0 0.1 0.0077 15.8 0.1 1.2 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase DDE_Tnp_ISAZ013 PF07592.6 KII68715.1 - 0.022 13.5 0.1 0.025 13.3 0.0 1.1 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain ITAM_Cys-rich PF10538.4 KII68715.1 - 0.036 13.6 0.3 0.064 12.8 0.2 1.4 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif Adap_comp_sub PF00928.16 KII68715.1 - 0.074 12.1 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Adaptor complexes medium subunit family Vac14_Fab1_bd PF12755.2 KII68716.1 - 1.1e-05 25.7 0.4 0.0001 22.5 0.0 2.1 2 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region DUF4294 PF14127.1 KII68716.1 - 0.053 13.1 0.1 0.066 12.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) DDE_Tnp_IS1595 PF12762.2 KII68717.1 - 4.5e-07 29.8 0.0 4.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Diphthamide_syn PF01866.12 KII68718.1 - 1.5e-39 136.0 4.4 3.8e-37 128.1 2.8 2.5 1 1 0 1 1 1 1 Putative diphthamide synthesis protein DDE_3 PF13358.1 KII68719.1 - 7.5e-22 77.6 0.0 1.3e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII68719.1 - 1.3e-08 34.9 0.0 2.3e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII68719.1 - 1.9e-06 27.3 0.0 0.00013 21.4 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.1 KII68719.1 - 2.4e-06 28.2 0.0 4.5e-05 24.1 0.0 2.5 1 1 1 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.7 KII68719.1 - 0.0024 17.2 0.1 0.057 12.8 0.0 2.4 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_Tnp_Tc3_2 PF01498.13 KII68719.1 - 0.0036 17.3 0.0 0.011 15.8 0.0 1.9 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.1 KII68719.1 - 0.0036 17.2 0.1 0.057 13.4 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4 PF04545.11 KII68719.1 - 0.023 13.9 0.0 0.064 12.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_3 PF01381.17 KII68719.1 - 0.031 14.1 0.1 10 6.0 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix HTH_19 PF12844.2 KII68719.1 - 0.05 13.6 0.2 6.4 6.9 0.0 2.8 2 1 0 2 2 2 0 Helix-turn-helix domain PAX PF00292.13 KII68719.1 - 0.051 13.2 0.1 1.7 8.3 0.1 2.6 2 1 1 3 3 3 0 'Paired box' domain HTH_37 PF13744.1 KII68719.1 - 0.13 12.0 0.2 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_17 PF12728.2 KII68719.1 - 0.13 12.5 0.3 2.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Mito_carr PF00153.22 KII68720.1 - 0.013 15.2 0.1 0.053 13.2 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial carrier protein Ig_3 PF13927.1 KII68721.1 - 0.05 14.1 0.5 0.16 12.4 0.0 2.0 2 1 0 2 2 2 0 Immunoglobulin domain APC8 PF04049.8 KII68721.1 - 0.12 12.1 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Anaphase promoting complex subunit 8 / Cdc23 Peptidase_M24 PF00557.19 KII68723.1 - 2.6e-46 157.8 0.1 3e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 ATP-cone PF03477.11 KII68723.1 - 1.3e-05 25.5 0.1 0.00089 19.6 0.1 2.3 2 0 0 2 2 2 1 ATP cone domain Ribosomal_S26e PF01283.14 KII68724.1 - 6.9e-45 151.9 5.5 8.4e-45 151.6 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4 PF00037.22 KII68724.1 - 0.075 12.6 3.2 0.11 12.0 0.7 2.0 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_7 PF12838.2 KII68724.1 - 0.077 13.3 2.4 0.26 11.7 0.3 2.2 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_17 PF13534.1 KII68724.1 - 0.087 13.1 0.9 2.2 8.7 0.2 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_10 PF13237.1 KII68724.1 - 0.099 12.4 2.7 0.12 12.1 0.6 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.1 KII68724.1 - 0.16 12.2 2.7 0.43 10.8 1.9 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.2 KII68724.1 - 0.44 10.5 3.1 1.2 9.2 0.9 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain THOC7 PF05615.8 KII68725.1 - 8.1e-12 45.5 4.4 8.1e-12 45.5 3.1 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 Effector_1 PF04518.7 KII68725.1 - 0.007 15.3 2.4 0.007 15.3 1.7 1.6 1 1 0 1 1 1 1 Effector from type III secretion system Mnd1 PF03962.10 KII68725.1 - 0.026 14.1 5.0 1.5 8.4 0.1 2.2 1 1 1 2 2 2 0 Mnd1 family TPR_MLP1_2 PF07926.7 KII68725.1 - 0.073 12.8 7.6 0.15 11.8 5.3 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.7 KII68725.1 - 0.075 12.8 1.7 3.1 7.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1845 PF08900.6 KII68725.1 - 0.13 11.5 0.9 0.23 10.7 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1845) Seryl_tRNA_N PF02403.17 KII68725.1 - 0.22 11.5 4.8 2.8 8.0 2.0 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain bZIP_2 PF07716.10 KII68725.1 - 0.25 11.1 0.1 0.25 11.1 0.1 2.4 3 0 0 3 3 3 0 Basic region leucine zipper HR1 PF02185.11 KII68725.1 - 0.28 10.9 3.8 0.94 9.2 2.6 2.1 1 1 0 1 1 1 0 Hr1 repeat FemAB PF02388.11 KII68725.1 - 0.31 9.6 4.5 0.36 9.4 3.1 1.1 1 0 0 1 1 1 0 FemAB family IncA PF04156.9 KII68725.1 - 0.93 9.0 14.3 1.5 8.3 1.9 2.2 1 1 1 2 2 2 0 IncA protein Sec8_exocyst PF04048.9 KII68725.1 - 0.98 9.0 6.1 1.3 8.6 0.5 2.3 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF3496 PF12001.3 KII68725.1 - 3.3 7.9 8.4 1.6 9.0 1.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3496) Mto2_bdg PF12808.2 KII68725.1 - 5.9 7.0 9.1 0.7 10.0 0.2 2.9 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Pyr_redox_dim PF02852.17 KII68726.1 - 3.1e-23 81.8 0.0 4.7e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 KII68726.1 - 5e-05 23.2 0.0 8.1e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase BOP1NT PF08145.7 KII68727.1 - 5.6e-06 26.2 3.2 5.6e-06 26.2 2.2 1.8 2 0 0 2 2 2 1 BOP1NT (NUC169) domain WD40 PF00400.27 KII68727.1 - 7.1e-06 25.7 0.0 0.00027 20.7 0.0 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat BOP1NT PF08145.7 KII68728.1 - 1.9e-17 63.8 0.0 2.2e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 BOP1NT (NUC169) domain Mak16 PF04874.9 KII68728.1 - 0.13 12.3 0.1 0.24 11.4 0.0 1.5 2 0 0 2 2 2 0 Mak16 protein C-terminal region F-actin_cap_A PF01267.12 KII68731.1 - 7.1e-62 208.9 1.5 7.9e-62 208.7 1.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit ATP_bind_4 PF01902.12 KII68732.1 - 1.5e-12 47.3 0.0 1.8e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 ATP-binding region ATP_bind_4 PF01902.12 KII68733.1 - 3.4e-07 29.8 0.2 1.4e-06 27.8 0.1 1.7 1 1 0 1 1 1 1 ATP-binding region QueC PF06508.8 KII68733.1 - 0.043 13.0 0.0 0.065 12.5 0.0 1.5 1 1 0 1 1 1 0 Queuosine biosynthesis protein QueC G6PD_C PF02781.11 KII68737.1 - 7e-44 149.8 0.0 1.4e-43 148.8 0.0 1.5 1 1 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain Dynactin_p22 PF07426.6 KII68738.1 - 0.027 13.7 0.4 0.052 12.8 0.2 1.4 1 0 0 1 1 1 0 Dynactin subunit p22 SRP54 PF00448.17 KII68739.1 - 2e-77 259.1 0.3 3.7e-77 258.2 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 KII68739.1 - 3.2e-24 85.1 0.6 3.2e-24 85.1 0.4 3.0 3 0 0 3 3 3 1 Signal peptide binding domain cobW PF02492.14 KII68739.1 - 1.7e-08 34.1 0.5 1.1e-07 31.4 0.3 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 KII68739.1 - 2.1e-07 30.9 0.0 4.5e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain CbiA PF01656.18 KII68739.1 - 1.7e-06 27.5 0.1 1.1e-05 24.9 0.1 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 KII68739.1 - 2.4e-06 27.3 0.5 1.2e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B DUF2209 PF09974.4 KII68739.1 - 0.00017 21.6 0.3 0.00035 20.6 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) AAA_17 PF13207.1 KII68739.1 - 0.00047 20.9 0.0 0.0011 19.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII68739.1 - 0.00048 20.2 0.0 0.0021 18.2 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.1 KII68739.1 - 0.00075 19.4 0.1 1.3 8.9 0.0 2.6 1 1 1 2 2 2 2 AAA domain SRPRB PF09439.5 KII68739.1 - 0.0012 18.1 1.7 0.39 9.9 0.6 2.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit APS_kinase PF01583.15 KII68739.1 - 0.0028 17.3 0.0 0.0086 15.7 0.0 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_16 PF13191.1 KII68739.1 - 0.0036 17.3 0.0 0.0067 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain ATP_bind_1 PF03029.12 KII68739.1 - 0.004 16.7 0.1 0.013 15.0 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_30 PF13604.1 KII68739.1 - 0.0042 16.6 0.0 0.01 15.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KII68739.1 - 0.0084 15.2 0.0 0.051 12.6 0.0 2.1 2 1 0 2 2 2 1 Zeta toxin PduV-EutP PF10662.4 KII68739.1 - 0.011 15.2 0.5 2.6 7.5 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 KII68739.1 - 0.02 14.8 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.12 KII68739.1 - 0.034 13.5 0.0 0.086 12.2 0.0 1.7 1 0 0 1 1 1 0 Thymidylate kinase AAA PF00004.24 KII68739.1 - 0.042 14.0 0.2 0.28 11.3 0.1 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 KII68739.1 - 0.047 13.1 0.1 0.16 11.3 0.0 2.0 1 1 0 1 1 1 0 AAA-like domain AAA_18 PF13238.1 KII68739.1 - 0.047 13.9 0.0 0.23 11.7 0.0 2.3 1 1 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.7 KII68739.1 - 0.048 12.8 0.5 0.14 11.2 0.3 1.8 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF659 PF04937.10 KII68739.1 - 0.067 12.6 0.3 0.17 11.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) 6PF2K PF01591.13 KII68739.1 - 0.071 12.1 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase TrwB_AAD_bind PF10412.4 KII68739.1 - 0.084 11.4 0.0 0.19 10.2 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain KTI12 PF08433.5 KII68739.1 - 0.11 11.7 0.0 0.27 10.3 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Serpin PF00079.15 KII68741.1 - 1.3e-40 139.7 0.0 1.5e-40 139.4 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII68742.1 - 2.5e-43 148.6 0.4 6.8e-40 137.3 0.0 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) CDC45 PF02724.9 KII68742.1 - 3.6 5.4 7.4 4.8 5.1 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Serpin PF00079.15 KII68743.1 - 1.4e-21 77.1 1.7 1.5e-21 77.0 1.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-UBR PF02207.15 KII68747.1 - 1.7e-12 46.8 13.1 4.5e-12 45.5 9.1 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) PGP_phosphatase PF09419.5 KII68747.1 - 0.12 11.7 0.0 0.65 9.3 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase zf-B_box PF00643.19 KII68747.1 - 0.27 11.1 5.1 1 9.2 3.6 2.0 1 1 0 1 1 1 0 B-box zinc finger zf-UBR PF02207.15 KII68748.1 - 3e-12 46.0 15.8 3e-12 46.0 11.0 1.8 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) DDE_Tnp_IS1595 PF12762.2 KII68750.1 - 1.7e-22 79.9 0.0 7.9e-22 77.7 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain rve PF00665.21 KII68752.1 - 4.8e-18 65.4 0.0 8e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII68752.1 - 9.1e-06 25.1 0.1 3e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain UN_NPL4 PF11543.3 KII68752.1 - 0.058 13.6 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 tRNA_m1G_MT PF01746.16 KII68752.1 - 0.081 12.5 0.3 0.31 10.6 0.1 1.9 1 1 1 2 2 2 0 tRNA (Guanine-1)-methyltransferase DUF4358 PF14270.1 KII68752.1 - 0.1 12.4 0.1 13 5.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Med26 PF08711.6 KII68753.1 - 1e-11 44.1 0.7 1.9e-11 43.3 0.5 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain LEDGF PF11467.3 KII68753.1 - 7.8e-05 22.3 0.3 0.0001 21.9 0.2 1.1 1 0 0 1 1 1 1 Lens epithelium-derived growth factor (LEDGF) PDZ_2 PF13180.1 KII68756.1 - 0.03 14.2 0.9 0.065 13.1 0.6 1.6 1 0 0 1 1 1 0 PDZ domain Homeobox PF00046.24 KII68757.1 - 2.5e-14 52.6 6.9 5.8e-13 48.2 3.2 2.2 2 0 0 2 2 2 2 Homeobox domain Homeobox_KN PF05920.6 KII68757.1 - 0.0027 17.3 2.7 0.0098 15.5 0.9 2.4 3 0 0 3 3 3 1 Homeobox KN domain Phage_terminase PF10668.4 KII68757.1 - 0.062 13.0 0.4 0.12 12.2 0.3 1.4 1 0 0 1 1 1 0 Phage terminase small subunit DUF896 PF05979.7 KII68757.1 - 0.066 12.8 1.8 0.12 11.9 1.3 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) Homeobox PF00046.24 KII68758.1 - 3.3e-17 61.8 6.9 6e-16 57.8 3.1 2.4 2 0 0 2 2 2 2 Homeobox domain Homeobox_KN PF05920.6 KII68758.1 - 0.029 14.0 1.3 0.27 10.9 0.1 2.5 2 0 0 2 2 2 0 Homeobox KN domain Homez PF11569.3 KII68758.1 - 0.059 12.4 1.3 8.1 5.5 0.1 2.4 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez DUF605 PF04652.11 KII68758.1 - 0.11 11.8 15.6 0.13 11.6 10.8 1.1 1 0 0 1 1 1 0 Vta1 like Pribosyl_synth PF14572.1 KII68759.1 - 4.4e-31 108.0 2.3 5.3e-31 107.8 1.6 1.1 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 KII68759.1 - 2.2e-10 40.3 0.5 3.8e-10 39.5 0.3 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KII68759.1 - 5.1e-07 29.1 0.7 6.3e-07 28.8 0.5 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase QRPTase_C PF01729.14 KII68759.1 - 0.0098 15.4 0.8 0.013 14.9 0.6 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain PRTase_2 PF15609.1 KII68759.1 - 0.0099 15.1 0.1 0.012 14.8 0.1 1.3 1 1 0 1 1 1 1 Phosphoribosyl transferase CDKN3 PF05706.7 KII68759.1 - 0.063 12.7 0.1 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) FtsA PF14450.1 KII68759.1 - 0.12 12.1 0.5 0.15 11.8 0.4 1.1 1 0 0 1 1 1 0 Cell division protein FtsA Pribosyltran_N PF13793.1 KII68760.1 - 8.6e-43 144.7 0.0 1.1e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase BNR PF02012.15 KII68761.1 - 3.6e-05 22.9 2.1 1.2 9.2 0.0 3.8 3 0 0 3 3 3 3 BNR/Asp-box repeat Spc7_C2 PF15577.1 KII68763.1 - 0.083 12.5 0.2 0.14 11.7 0.2 1.4 1 0 0 1 1 1 0 Spc7_C2 Chromo_shadow PF01393.14 KII68766.1 - 0.062 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Chromo shadow domain MecA_N PF05223.6 KII68767.1 - 0.12 12.5 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain DUF4367 PF14285.1 KII68767.1 - 0.85 8.9 5.3 1.4 8.2 3.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4367) DUF4245 PF14030.1 KII68768.1 - 0.08 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) BAG PF02179.11 KII68769.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 BAG domain zf-RING_4 PF14570.1 KII68770.1 - 0.2 11.2 1.5 0.5 9.9 0.0 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF1253 PF06862.7 KII68771.1 - 0.015 13.6 0.1 0.017 13.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1253) Ribosomal_L37e PF01907.14 KII68771.1 - 0.053 13.3 2.2 0.12 12.2 1.5 1.6 1 0 0 1 1 1 0 Ribosomal protein L37e zinc_ribbon_2 PF13240.1 KII68771.1 - 0.067 12.7 2.6 5.4 6.6 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain HNH_5 PF14279.1 KII68771.1 - 0.08 12.9 1.8 1.7 8.7 0.8 2.6 2 0 0 2 2 2 0 HNH endonuclease DZR PF12773.2 KII68771.1 - 0.86 9.4 6.6 6 6.7 4.6 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-CCHC PF00098.18 KII68771.1 - 3 7.9 7.9 6.7 6.8 0.9 2.5 2 0 0 2 2 2 0 Zinc knuckle DUF1845 PF08900.6 KII68773.1 - 0.011 14.9 9.0 18 4.5 0.2 4.6 1 1 6 7 7 7 0 Domain of unknown function (DUF1845) Meleagrin PF08189.6 KII68774.1 - 0.027 13.9 0.3 0.043 13.2 0.2 1.3 1 0 0 1 1 1 0 Meleagrin/Cygnin family DUF728 PF05304.7 KII68774.1 - 0.03 14.5 0.1 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF728) Asp_protease_2 PF13650.1 KII68775.1 - 4.9e-08 33.3 0.0 6.9e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII68775.1 - 3.3e-06 26.8 0.0 5.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII68775.1 - 5.1e-06 26.3 0.0 7.1e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII68775.1 - 0.00034 20.4 1.9 0.00034 20.4 1.3 2.7 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_6 PF15288.1 KII68775.1 - 0.02 14.5 1.7 0.02 14.5 1.2 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-BED PF02892.10 KII68775.1 - 0.12 12.1 2.6 0.33 10.7 1.8 1.8 1 0 0 1 1 1 0 BED zinc finger zf-CCHC_4 PF14392.1 KII68775.1 - 0.3 10.7 8.5 0.32 10.7 1.4 3.1 2 1 1 3 3 3 0 Zinc knuckle zf-CCHC_5 PF14787.1 KII68775.1 - 0.45 10.0 9.0 1.8 8.1 0.4 2.6 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger Ribosomal_L37e PF01907.14 KII68775.1 - 0.92 9.3 7.5 8.4 6.2 5.2 2.2 1 1 0 1 1 1 0 Ribosomal protein L37e RVT_3 PF13456.1 KII68776.1 - 0.085 12.6 0.0 0.25 11.1 0.0 1.8 2 0 0 2 2 2 0 Reverse transcriptase-like rve PF00665.21 KII68777.1 - 6.4e-28 97.2 0.1 1.1e-27 96.5 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII68777.1 - 0.00038 19.9 0.0 0.00085 18.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII68777.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 DDE domain ETX_MTX2 PF03318.8 KII68779.1 - 0.026 14.0 0.1 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Phage_int_SAM_4 PF13495.1 KII68780.1 - 0.13 12.6 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Asp_protease_2 PF13650.1 KII68781.1 - 1.4e-07 31.9 0.0 2.5e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII68781.1 - 8.4e-06 25.5 0.0 1.5e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII68781.1 - 2e-05 24.4 0.0 4.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII68781.1 - 0.00069 19.4 1.9 0.00069 19.4 1.3 2.6 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_6 PF15288.1 KII68781.1 - 0.042 13.5 1.7 0.042 13.5 1.2 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-BED PF02892.10 KII68781.1 - 0.26 11.0 2.6 0.76 9.5 1.8 1.8 1 0 0 1 1 1 0 BED zinc finger zf-CCHC_5 PF14787.1 KII68781.1 - 0.54 9.7 7.2 5.6 6.5 0.7 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 KII68781.1 - 1.6 8.4 8.7 0.79 9.4 1.5 3.1 2 1 1 3 3 3 0 Zinc knuckle Ribosomal_L37e PF01907.14 KII68781.1 - 5 6.9 8.9 6.7 6.5 4.1 2.5 2 1 1 3 3 3 0 Ribosomal protein L37e RVT_3 PF13456.1 KII68782.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like GBP_PSP PF02425.10 KII68785.1 - 0.22 11.0 0.8 6.3 6.4 0.1 2.9 3 0 0 3 3 3 0 Paralytic/GBP/PSP peptide Pex24p PF06398.6 KII68786.1 - 0.37 9.5 4.3 0.34 9.6 2.5 1.3 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin zf-CCHC PF00098.18 KII68788.1 - 0.00012 21.7 11.7 0.0017 18.1 2.2 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 KII68788.1 - 0.022 14.3 7.1 0.77 9.4 0.3 2.7 2 0 0 2 2 2 0 Zinc knuckle PARP_regulatory PF01358.13 KII68791.1 - 0.077 11.6 0.0 0.095 11.3 0.0 1.1 1 0 0 1 1 1 0 Poly A polymerase regulatory subunit Oleosin PF01277.12 KII68793.1 - 0.025 14.1 0.1 0.055 13.0 0.0 1.5 2 0 0 2 2 2 0 Oleosin DDE_Tnp_IS1595 PF12762.2 KII68796.1 - 0.0054 16.5 0.4 0.0096 15.7 0.3 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF3836 PF12930.2 KII68796.1 - 0.06 12.8 0.2 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF3836) DUF2458 PF10454.4 KII68799.1 - 0.013 15.3 1.4 0.037 13.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2458) Lge1 PF11488.3 KII68799.1 - 0.12 12.6 0.2 0.45 10.7 0.0 1.9 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 Peptidase_S9 PF00326.16 KII68801.1 - 3.8e-17 62.2 0.0 5.9e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 KII68801.1 - 2.2e-06 27.4 0.0 0.0001 21.9 0.0 2.3 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.13 KII68801.1 - 6.6e-06 25.5 0.0 0.03 13.6 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 KII68801.1 - 5.2e-05 23.0 0.0 9.7e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KII68801.1 - 6.1e-05 23.0 0.0 0.00027 20.8 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF4371 PF14291.1 KII68802.1 - 0.069 12.6 0.9 0.099 12.1 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4371) Metallophos PF00149.23 KII68803.1 - 8.2e-07 28.6 0.1 1e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KII68803.1 - 0.0083 15.9 0.0 0.012 15.4 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KII68804.1 - 4.1e-06 26.3 0.9 5.2e-06 25.9 0.6 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ISK_Channel PF02060.10 KII68804.1 - 0.026 14.0 0.3 0.08 12.5 0.0 1.7 1 1 1 2 2 2 0 Slow voltage-gated potassium channel Metallophos_2 PF12850.2 KII68804.1 - 0.031 14.1 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Pyridox_oxidase PF01243.15 KII68805.1 - 6.8e-21 74.0 0.0 9.8e-21 73.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.2 KII68805.1 - 5.1e-08 33.1 0.0 8.1e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DDE_3 PF13358.1 KII68806.1 - 3.1e-06 27.0 0.1 4.4e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF713 PF05218.9 KII68822.1 - 0.024 14.3 1.5 0.028 14.1 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF713) Not3 PF04065.10 KII68822.1 - 0.034 13.4 1.0 0.038 13.2 0.7 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DDE_3 PF13358.1 KII68826.1 - 0.014 15.1 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF3430 PF11912.3 KII68827.1 - 0.038 13.7 3.0 0.031 14.0 1.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3430) Inos-1-P_synth PF01658.12 KII68827.1 - 1.6 8.5 4.5 0.64 9.8 0.2 2.0 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase BNR PF02012.15 KII68828.1 - 0.00093 18.6 6.3 6.5 7.0 0.0 5.0 5 0 0 5 5 5 3 BNR/Asp-box repeat SNAP PF14938.1 KII68829.1 - 9.2e-13 47.9 7.2 1e-12 47.8 5.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII68829.1 - 0.00026 20.5 6.6 0.00043 19.8 1.1 2.7 1 1 2 3 3 3 1 TPR repeat TPR_12 PF13424.1 KII68829.1 - 0.014 15.3 4.3 0.87 9.5 0.5 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII68829.1 - 0.13 12.2 10.6 2.5 8.2 1.2 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII68829.1 - 0.23 11.3 8.6 1.9 8.4 0.2 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII68829.1 - 0.69 9.6 12.2 3.6 7.3 1.5 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.1 KII68830.1 - 7.1e-09 35.2 6.6 8.6e-09 34.9 4.5 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.1 KII68830.1 - 0.0019 17.8 7.8 4.5 7.2 0.1 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 KII68830.1 - 0.0026 17.6 5.6 0.27 11.2 1.7 2.9 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII68830.1 - 0.089 12.7 8.1 0.39 10.7 0.5 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII68830.1 - 0.67 9.6 7.9 3.6 7.3 1.8 2.9 2 2 0 2 2 2 0 TPR repeat Strep_SA_rep PF06696.6 KII68830.1 - 1.7 8.4 5.2 25 4.7 0.3 3.2 2 1 1 3 3 3 0 Streptococcal surface antigen repeat NSF PF02071.15 KII68830.1 - 9.5 7.3 8.2 6.9 7.7 0.9 3.4 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat RVP PF00077.15 KII68831.1 - 6.8e-10 38.7 0.0 8.2e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII68831.1 - 0.0012 19.3 0.0 0.0015 18.9 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2E PF12382.3 KII68831.1 - 0.0026 17.5 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon peptidase gag-asp_proteas PF13975.1 KII68831.1 - 0.0044 16.8 0.0 0.0071 16.1 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RST PF12174.3 KII68832.1 - 0.027 14.2 0.1 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain DSX_dimer PF08828.5 KII68832.1 - 0.081 12.4 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Doublesex dimerisation domain rve PF00665.21 KII68833.1 - 1.8e-11 44.1 0.1 2.2e-11 43.8 0.1 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII68833.1 - 0.00032 20.1 0.0 0.00047 19.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF3293 PF11697.3 KII68833.1 - 0.0075 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3293) SNAP PF14938.1 KII68835.1 - 2.1e-07 30.3 0.1 2.7e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII68835.1 - 0.0034 17.0 0.2 0.013 15.1 0.1 2.0 1 1 1 2 2 2 2 TPR repeat CtIP_N PF10482.4 KII68835.1 - 0.23 11.2 3.5 0.93 9.2 1.0 2.5 2 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain SNAP PF14938.1 KII68838.1 - 1.9e-05 23.9 0.1 2.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP CZB PF13682.1 KII68839.1 - 0.22 11.6 2.6 0.16 12.1 0.5 1.7 2 0 0 2 2 2 0 Chemoreceptor zinc-binding domain SNAP PF14938.1 KII68840.1 - 4.1e-07 29.4 0.3 5.2e-07 29.1 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF3972 PF13118.1 KII68840.1 - 0.082 12.9 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) TPR_2 PF07719.12 KII68840.1 - 0.15 12.0 4.3 21 5.3 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII68840.1 - 0.83 9.3 3.3 22 4.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.1 KII68842.1 - 0.00032 19.9 0.4 0.00063 18.9 0.0 1.6 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII68842.1 - 0.19 11.7 1.8 5.1 7.2 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII68842.1 - 2.9 7.8 4.8 2.1 8.3 0.4 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF919 PF06034.6 KII68843.1 - 0.035 13.7 0.1 0.077 12.6 0.1 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) TMEM154 PF15102.1 KII68844.1 - 0.014 15.0 0.4 0.046 13.4 0.3 1.8 1 1 0 1 1 1 0 TMEM154 protein family DAD PF02109.11 KII68844.1 - 0.082 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 DAD family SNAP PF14938.1 KII68845.1 - 1e-09 37.9 0.2 1.7e-09 37.2 0.1 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Bcl-2 PF00452.14 KII68845.1 - 0.12 12.5 0.0 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family OSTMP1 PF09777.4 KII68845.1 - 3.4 6.7 9.7 3.1 6.8 4.4 2.3 2 1 0 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor SNAP PF14938.1 KII68847.1 - 0.00014 21.0 0.1 0.00028 20.1 0.0 1.4 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP VCBS PF13517.1 KII68848.1 - 0.0065 16.8 0.6 0.021 15.1 0.0 2.2 2 1 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella zf-SAP30 PF13866.1 KII68848.1 - 0.039 13.5 0.1 0.11 12.1 0.1 1.7 1 0 0 1 1 1 0 SAP30 zinc-finger MtrD PF04207.7 KII68848.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit D FG-GAP PF01839.18 KII68848.1 - 0.15 11.8 3.2 0.099 12.3 0.6 2.0 2 0 0 2 2 2 0 FG-GAP repeat FG-GAP_2 PF14312.1 KII68849.1 - 0.22 11.5 1.1 0.43 10.6 0.7 1.5 1 1 0 1 1 1 0 FG-GAP repeat rve PF00665.21 KII68853.1 - 6.2e-13 48.9 0.0 1.4e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain FG-GAP PF01839.18 KII68853.1 - 0.0033 17.0 0.7 0.0076 15.9 0.5 1.7 1 0 0 1 1 1 1 FG-GAP repeat VCBS PF13517.1 KII68853.1 - 0.0041 17.4 0.5 0.04 14.2 0.3 2.3 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella rve_3 PF13683.1 KII68853.1 - 0.068 12.6 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain VCBS PF13517.1 KII68855.1 - 0.00097 19.4 1.4 0.041 14.2 0.6 3.1 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII68855.1 - 0.0029 17.2 2.7 0.0072 15.9 1.9 1.7 1 0 0 1 1 1 1 FG-GAP repeat DUF4387 PF14330.1 KII68855.1 - 0.053 13.8 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4387) CS PF04969.11 KII68855.1 - 0.11 13.0 0.2 0.84 10.2 0.0 2.5 1 1 3 4 4 4 0 CS domain Armet PF10208.4 KII68856.1 - 1.3e-21 76.8 6.6 1.8e-21 76.4 4.6 1.1 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding V-set_CD47 PF08204.6 KII68856.1 - 0.093 12.4 2.5 6.2 6.6 0.2 2.1 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Clathrin_H_link PF13838.1 KII68857.1 - 7.1e-16 57.8 0.1 3e-15 55.8 0.0 2.1 2 0 0 2 2 2 1 Clathrin-H-link Clathrin PF00637.15 KII68857.1 - 7.6e-11 41.7 6.1 2.8e-10 39.9 2.4 2.8 2 1 0 2 2 2 1 Region in Clathrin and VPS Clathrin_propel PF01394.15 KII68857.1 - 0.005 17.0 4.2 1.4 9.3 0.2 3.9 3 0 0 3 3 3 2 Clathrin propeller repeat TPR_1 PF00515.23 KII68857.1 - 0.1 12.2 1.5 15 5.3 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF972 PF06156.8 KII68860.1 - 0.014 15.7 0.3 0.016 15.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) pRN1_helical PF13010.1 KII68860.1 - 0.047 13.3 0.1 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 Primase helical domain Peptidase_M85 PF13678.1 KII68860.1 - 0.085 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 NFkB-p65-degrading zinc protease C2-set PF05790.10 KII68860.1 - 0.13 12.2 0.1 0.28 11.1 0.1 1.6 1 1 1 2 2 2 0 Immunoglobulin C2-set domain DDE_Tnp_1_7 PF13843.1 KII68862.1 - 1e-24 87.2 0.2 1.2e-24 86.9 0.2 1.0 1 0 0 1 1 1 1 Transposase IS4 YbaJ PF10757.4 KII68862.1 - 0.048 13.7 0.1 0.067 13.3 0.0 1.2 1 0 0 1 1 1 0 Biofilm formation regulator YbaJ DUF4398 PF14346.1 KII68865.1 - 2.7e-09 37.0 12.3 1.1 9.3 8.5 5.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4398) YfdX PF10938.3 KII68865.1 - 3e-09 36.7 0.0 0.011 15.4 0.0 3.9 1 1 2 3 3 3 2 YfdX protein WEMBL PF05701.6 KII68865.1 - 7.6e-09 34.5 6.4 6.5e-05 21.5 0.7 2.4 1 1 1 2 2 2 2 Weak chloroplast movement under blue light Borrelia_P83 PF05262.6 KII68865.1 - 7.6e-06 24.4 8.1 0.044 12.0 5.6 2.6 1 1 0 1 1 1 1 Borrelia P83/100 protein DUF3584 PF12128.3 KII68865.1 - 0.0012 16.2 3.8 0.1 9.9 0.3 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3584) DUF3166 PF11365.3 KII68865.1 - 0.043 14.2 11.2 28 5.2 0.8 4.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3166) Cast PF10174.4 KII68865.1 - 0.1 10.6 12.7 0.25 9.3 8.8 1.6 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone DUF4266 PF14086.1 KII68865.1 - 0.12 12.8 35.9 37 4.9 0.9 8.5 1 1 5 6 6 6 0 Domain of unknown function (DUF4266) DUF745 PF05335.8 KII68865.1 - 0.44 10.0 6.1 2.1 7.7 1.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) RVT_1 PF00078.22 KII68868.1 - 0.0012 18.1 0.1 0.0017 17.7 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Hum_adeno_E3A PF05393.6 KII68870.1 - 0.036 13.7 0.6 0.045 13.4 0.4 1.2 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein RVT_1 PF00078.22 KII68873.1 - 6.8e-17 61.5 0.1 1.2e-16 60.6 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_IS1595 PF12762.2 KII68875.1 - 2.8e-07 30.4 0.1 2.2e-06 27.5 0.1 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain Senescence_reg PF04520.8 KII68877.1 - 0.05 14.0 1.7 0.068 13.6 1.2 1.3 1 0 0 1 1 1 0 Senescence regulator AA_synth PF06684.6 KII68877.1 - 0.086 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Amino acid synthesis DUF1499 PF07386.6 KII68878.1 - 0.79 9.9 3.6 1.8 8.7 2.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1499) Senescence_reg PF04520.8 KII68879.1 - 0.05 14.0 1.7 0.068 13.6 1.2 1.3 1 0 0 1 1 1 0 Senescence regulator AA_synth PF06684.6 KII68879.1 - 0.086 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Amino acid synthesis DUF155 PF02582.9 KII68880.1 - 0.056 13.3 1.9 0.75 9.6 0.4 2.5 2 1 0 2 2 2 0 Uncharacterised ACR, YagE family COG1723 rve PF00665.21 KII68883.1 - 2e-21 76.3 0.0 3.3e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII68883.1 - 0.0031 17.0 0.0 0.0058 16.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RAG2_PHD PF13341.1 KII68883.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 RAG2 PHD domain Ldl_recept_a PF00057.13 KII68885.1 - 2e-13 49.9 66.3 0.00018 21.3 7.5 4.5 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A Syndecan PF01034.15 KII68886.1 - 0.13 11.9 1.2 0.2 11.3 0.9 1.3 1 0 0 1 1 1 0 Syndecan domain Orthopox_A36R PF05950.6 KII68886.1 - 0.14 12.0 0.5 0.2 11.5 0.3 1.3 1 0 0 1 1 1 0 Orthopoxvirus A36R protein EVI2A PF05399.6 KII68886.1 - 0.6 9.3 2.7 0.7 9.1 1.9 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Shisa PF13908.1 KII68886.1 - 0.88 9.7 3.0 1.1 9.4 2.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Ldl_recept_a PF00057.13 KII68887.1 - 4.4e-12 45.7 32.4 7e-07 29.0 8.7 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII68887.1 - 6.3 6.3 21.0 45 3.5 14.5 1.9 1 1 0 1 1 1 0 Glucosidase II beta subunit-like BNR PF02012.15 KII68888.1 - 0.0012 18.3 7.7 0.52 10.3 0.2 4.1 4 0 0 4 4 4 2 BNR/Asp-box repeat Phlebovirus_G1 PF07243.6 KII68889.1 - 0.095 10.8 0.0 0.1 10.7 0.0 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G1 Nucleoside_tran PF01733.13 KII68891.1 - 3.6e-10 39.4 3.7 4e-10 39.3 2.6 1.0 1 0 0 1 1 1 1 Nucleoside transporter DUF2101 PF09874.4 KII68891.1 - 0.12 11.8 6.6 0.13 11.6 4.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) Ldl_recept_a PF00057.13 KII68892.1 - 7.6e-29 99.3 44.6 3.5e-11 42.7 7.9 3.2 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A PUA PF01472.15 KII68892.1 - 0.14 11.8 0.2 1.1 9.0 0.1 2.0 1 1 1 2 2 2 0 PUA domain YcxB PF14317.1 KII68893.1 - 0.16 11.2 6.1 0.33 10.2 1.2 3.0 2 2 0 2 2 2 0 YcxB-like protein SPOR PF05036.8 KII68903.1 - 0.017 15.3 0.1 0.031 14.4 0.1 1.5 1 0 0 1 1 1 0 Sporulation related domain Ldl_recept_a PF00057.13 KII68906.1 - 5.1e-11 42.2 31.6 6.4e-06 25.9 9.5 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII68906.1 - 4.4 6.8 16.6 24 4.4 11.5 1.9 1 1 0 1 1 1 0 Glucosidase II beta subunit-like DUF3023 PF11224.3 KII68907.1 - 0.55 9.8 5.3 0.39 10.3 2.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3023) Ldl_recept_a PF00057.13 KII68908.1 - 1.7e-11 43.8 31.8 7.4e-06 25.7 8.8 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII68908.1 - 3.1 7.3 19.7 21 4.6 13.7 1.8 1 1 0 1 1 1 0 Glucosidase II beta subunit-like Ldl_recept_a PF00057.13 KII68909.1 - 2.6e-22 78.4 45.5 3.9e-10 39.4 6.6 3.3 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A DUF4105 PF13387.1 KII68912.1 - 0.015 14.4 0.2 0.018 14.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) SRR PF07709.6 KII68912.1 - 6.4 7.4 6.5 25 5.6 0.1 3.6 3 0 0 3 3 3 0 Seven Residue Repeat RVT_1 PF00078.22 KII68913.1 - 5.9e-05 22.5 0.2 0.18 11.1 0.0 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_tranf_2_4 PF13704.1 KII68915.1 - 0.13 12.6 0.0 0.14 12.4 0.0 1.3 1 1 0 1 1 1 0 Glycosyl transferase family 2 RVT_1 PF00078.22 KII68916.1 - 7.1e-13 48.4 0.0 1.2e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII68916.1 - 2.5e-07 30.5 0.0 6.7e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Spuma_A9PTase PF03539.9 KII68916.1 - 0.00026 20.9 0.0 0.0026 17.6 0.0 2.4 2 1 0 2 2 2 1 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII68916.1 - 0.0019 17.9 0.0 0.0049 16.6 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII68916.1 - 0.0043 17.5 0.0 0.0097 16.3 0.0 1.6 2 0 0 2 2 2 1 Aspartyl protease rve PF00665.21 KII68917.1 - 1.5e-16 60.6 0.0 4e-16 59.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII68917.1 - 0.0064 15.8 0.0 0.014 14.7 0.0 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DDE_3 PF13358.1 KII68918.1 - 9.7e-18 64.3 0.0 1.1e-17 64.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII68918.1 - 0.00037 19.6 0.0 0.00048 19.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Pectinesterase PF01095.14 KII68918.1 - 0.04 12.5 0.1 0.05 12.1 0.1 1.0 1 0 0 1 1 1 0 Pectinesterase RVT_1 PF00078.22 KII68919.1 - 3.5e-10 39.6 0.1 6.3e-10 38.7 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII68920.1 - 8.6e-14 51.6 0.0 9.8e-14 51.4 0.0 1.3 1 1 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII68921.1 - 6.8e-08 32.3 0.0 1e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII68921.1 - 7.2e-07 28.6 0.0 1.2e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix Lactamase_B_2 PF12706.2 KII68922.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain DUF3377 PF11857.3 KII68927.1 - 0.036 13.6 0.2 0.26 10.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) CagE_TrbE_VirB PF03135.9 KII68929.1 - 0.043 13.5 0.3 0.042 13.6 0.2 1.1 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system FLYWCH PF04500.11 KII68930.1 - 1.7e-06 27.8 0.0 3.5e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain EamA PF00892.15 KII68931.1 - 3.3e-15 56.2 44.2 1e-07 32.0 8.8 3.5 1 1 2 3 3 3 2 EamA-like transporter family EmrE PF13536.1 KII68931.1 - 0.016 15.3 7.3 0.016 15.3 5.1 3.9 2 1 2 4 4 4 0 Multidrug resistance efflux transporter Tmemb_14 PF03647.8 KII68931.1 - 0.13 12.7 11.7 0.24 11.8 0.2 3.1 2 2 1 3 3 3 0 Transmembrane proteins 14C MtrF PF09472.5 KII68931.1 - 0.54 9.5 11.5 1.3 8.3 0.1 4.1 4 0 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Syntaxin-6_N PF09177.6 KII68933.1 - 5.7e-05 23.4 4.6 0.0001 22.5 0.4 2.2 2 0 0 2 2 2 1 Syntaxin 6, N-terminal CCDC155 PF14662.1 KII68933.1 - 0.0094 15.5 0.5 0.0094 15.5 0.3 1.9 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 CENP-F_N PF10481.4 KII68933.1 - 0.031 13.6 8.0 0.039 13.3 5.5 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain GvpK PF05121.7 KII68933.1 - 0.073 12.8 0.5 0.073 12.8 0.3 2.0 2 1 0 2 2 2 0 Gas vesicle protein K Wbp11 PF09429.5 KII68933.1 - 0.15 12.0 6.5 0.49 10.4 0.8 2.4 2 0 0 2 2 2 0 WW domain binding protein 11 Vac_Fusion PF02346.11 KII68933.1 - 0.21 11.0 6.2 1.2 8.6 0.3 2.7 2 1 0 2 2 2 0 Chordopoxvirus fusion protein DUF3896 PF13035.1 KII68933.1 - 0.21 11.6 5.3 0.52 10.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) FliJ PF02050.11 KII68933.1 - 0.24 11.4 8.7 2.4 8.2 0.3 2.4 1 1 0 2 2 2 0 Flagellar FliJ protein Prefoldin_2 PF01920.15 KII68933.1 - 0.44 10.3 9.6 3.4 7.4 0.8 2.6 2 1 1 3 3 3 0 Prefoldin subunit DASH_Duo1 PF08651.5 KII68933.1 - 1.5 8.4 6.9 4.2 7.0 0.7 2.6 2 1 1 3 3 3 0 DASH complex subunit Duo1 DUF3949 PF13133.1 KII68933.1 - 7.3 6.9 6.6 28 5.0 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3949) HR1 PF02185.11 KII68933.1 - 9.6 6.0 11.6 9.5 6.0 1.1 3.2 2 1 1 3 3 3 0 Hr1 repeat TMF_DNA_bd PF12329.3 KII68933.1 - 9.8 6.0 10.0 4.3 7.1 0.4 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SNAP PF14938.1 KII68934.1 - 3.8e-08 32.8 1.1 5.1e-08 32.4 0.7 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.23 KII68934.1 - 2.1e-05 23.9 4.2 0.36 10.5 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII68934.1 - 0.001 18.9 1.2 2 8.4 0.0 3.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII68934.1 - 0.0017 18.0 5.4 0.36 10.8 0.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF4411 PF14367.1 KII68934.1 - 0.083 12.5 0.7 0.14 11.8 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4411) Rsa3 PF14615.1 KII68934.1 - 0.19 11.0 2.8 10 5.5 0.1 3.1 3 0 0 3 3 3 0 Ribosome-assembly protein 3 TPR_11 PF13414.1 KII68934.1 - 0.3 10.7 6.0 11 5.7 0.2 3.3 1 1 1 2 2 2 0 TPR repeat Tetraspannin PF00335.15 KII68936.1 - 1e-12 47.8 16.9 1.2e-12 47.5 11.7 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF3963 PF13124.1 KII68936.1 - 0.48 10.2 5.7 0.091 12.5 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3963) SUR7 PF06687.7 KII68936.1 - 0.58 9.6 9.6 4 6.9 0.1 2.2 2 0 0 2 2 2 0 SUR7/PalI family RNA_pol_L PF01193.19 KII68937.1 - 0.15 11.1 0.1 0.23 10.5 0.1 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Tetraspannin PF00335.15 KII68939.1 - 1.6e-08 34.1 10.4 2.5e-08 33.4 7.2 1.3 1 1 0 1 1 1 1 Tetraspanin family YxiJ PF14176.1 KII68940.1 - 0.044 13.8 0.1 0.061 13.4 0.1 1.2 1 0 0 1 1 1 0 YxiJ-like protein DDE_Tnp_IS1595 PF12762.2 KII68941.1 - 1.2e-14 54.4 0.5 4e-14 52.7 0.2 1.9 1 1 1 2 2 2 1 ISXO2-like transposase domain Tetraspannin PF00335.15 KII68942.1 - 4.9e-07 29.2 11.0 6.5e-07 28.8 7.6 1.2 1 0 0 1 1 1 1 Tetraspanin family Cytochrom_B_C PF00032.12 KII68942.1 - 0.025 14.7 5.1 0.041 14.1 3.5 1.5 1 1 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD SDF PF00375.13 KII68942.1 - 0.03 13.0 5.7 0.24 10.1 3.2 1.9 1 1 1 2 2 2 0 Sodium:dicarboxylate symporter family DUF3360 PF11840.3 KII68942.1 - 0.065 11.5 0.2 0.084 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3360) BatA PF07584.6 KII68942.1 - 0.38 10.9 2.5 0.71 10.0 1.8 1.4 1 1 0 1 1 1 0 Aerotolerance regulator N-terminal Na_Ca_ex PF01699.19 KII68942.1 - 0.67 9.5 8.1 1.1 8.8 5.6 1.4 1 0 0 1 1 1 0 Sodium/calcium exchanger protein DUF2207 PF09972.4 KII68942.1 - 1.5 7.2 8.0 1.6 7.2 5.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Tetraspannin PF00335.15 KII68943.1 - 8.2e-16 57.9 9.3 1e-15 57.6 6.5 1.1 1 0 0 1 1 1 1 Tetraspanin family MNNL PF07657.8 KII68943.1 - 0.083 12.8 1.0 0.17 11.8 0.7 1.5 1 0 0 1 1 1 0 N terminus of Notch ligand Caps_synth PF05704.7 KII68944.1 - 0.052 12.6 0.3 0.058 12.5 0.2 1.0 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Tetraspannin PF00335.15 KII68945.1 - 9.3e-12 44.6 9.0 1.2e-11 44.3 6.3 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF373 PF04123.8 KII68945.1 - 0.12 11.4 1.4 0.14 11.1 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) PrgI PF12666.2 KII68945.1 - 0.63 10.2 4.0 0.79 9.9 1.1 2.2 1 1 1 2 2 2 0 PrgI family protein DUF3747 PF12565.3 KII68946.1 - 0.056 12.5 0.0 0.076 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3747) Glycophorin_A PF01102.13 KII68946.1 - 0.079 12.7 1.2 0.093 12.5 0.8 1.3 1 1 0 1 1 1 0 Glycophorin A Adeno_E3_CR2 PF02439.10 KII68946.1 - 0.17 11.4 2.1 0.33 10.5 1.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 LSR PF05624.9 KII68946.1 - 2.3 7.9 4.6 0.49 10.1 0.9 1.6 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) DUF912 PF06024.7 KII68949.1 - 0.0051 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) ETRAMP PF09716.5 KII68949.1 - 0.093 12.6 0.9 0.22 11.4 0.2 1.9 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF3317 PF11779.3 KII68949.1 - 0.64 9.5 4.5 0.13 11.7 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3317) Spc24 PF08286.6 KII68949.1 - 5.5 6.7 11.6 5.5 6.7 6.2 2.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Paf1 PF03985.8 KII68949.1 - 7.2 5.2 14.4 11 4.6 10.0 1.2 1 0 0 1 1 1 0 Paf1 AstA PF04958.7 KII68950.1 - 0.095 11.1 0.0 0.14 10.5 0.0 1.1 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit Serpin PF00079.15 KII68952.1 - 1.9e-51 175.3 3.8 2.2e-51 175.1 2.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF2970 PF11174.3 KII68953.1 - 0.24 11.0 4.5 5 6.7 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Serpin PF00079.15 KII68955.1 - 7.4e-47 160.2 5.5 8e-47 160.1 3.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Bestrophin PF01062.16 KII68955.1 - 0.0012 17.8 0.1 0.0019 17.2 0.1 1.4 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF2414 PF10309.4 KII68956.1 - 0.041 13.5 0.4 0.079 12.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2414) Monellin PF09200.5 KII68956.1 - 0.099 12.2 0.1 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 Monellin Shisa PF13908.1 KII68957.1 - 0.004 17.3 0.4 0.0058 16.8 0.3 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.1 KII68957.1 - 0.0092 15.6 1.0 0.014 15.1 0.7 1.3 1 0 0 1 1 1 1 TMEM154 protein family Rifin_STEVOR PF02009.11 KII68957.1 - 0.016 14.9 0.9 0.021 14.4 0.6 1.3 1 0 0 1 1 1 0 Rifin/stevor family DUF3827 PF12877.2 KII68957.1 - 0.021 12.9 0.2 0.029 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) L1R_F9L PF02442.12 KII68957.1 - 0.036 13.5 0.5 0.086 12.2 0.0 1.8 1 1 0 1 1 1 0 Lipid membrane protein of large eukaryotic DNA viruses DUF4448 PF14610.1 KII68957.1 - 0.044 13.2 0.0 0.071 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF912 PF06024.7 KII68957.1 - 0.057 13.4 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Adeno_E3_CR2 PF02439.10 KII68957.1 - 0.22 11.0 4.5 0.41 10.2 3.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF3671 PF12420.3 KII68957.1 - 1.9 8.5 7.2 0.37 10.7 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function Lamp PF01299.12 KII68957.1 - 5.7 5.9 8.3 1.3 8.0 3.1 1.9 2 2 1 3 3 3 0 Lysosome-associated membrane glycoprotein (Lamp) DDE_3 PF13358.1 KII68958.1 - 3.7e-33 114.3 0.1 6.3e-33 113.5 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII68958.1 - 1.7e-09 37.8 0.1 3.7e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.1 KII68958.1 - 1e-06 28.1 0.2 0.00037 19.9 0.0 3.3 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 KII68958.1 - 1.4e-06 27.7 1.3 0.00019 20.9 0.0 3.2 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.1 KII68958.1 - 3.9e-06 26.7 0.5 9.1e-05 22.3 0.1 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.13 KII68958.1 - 0.0015 18.2 0.1 0.0032 17.1 0.1 1.7 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.1 KII68958.1 - 0.0019 17.9 0.0 0.0056 16.4 0.0 1.8 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII68958.1 - 0.0022 17.6 0.6 0.0049 16.5 0.4 1.6 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII68958.1 - 0.0026 18.5 0.0 0.0096 16.6 0.0 2.1 2 0 0 2 2 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII68958.1 - 0.0051 16.8 0.2 0.026 14.5 0.1 2.2 2 0 0 2 2 2 1 Transposase HTH_Tnp_1 PF01527.15 KII68958.1 - 0.0057 16.5 0.3 0.3 11.0 0.0 2.9 3 0 0 3 3 3 1 Transposase rve PF00665.21 KII68958.1 - 0.026 14.6 0.0 0.065 13.3 0.0 1.9 2 1 0 2 2 2 0 Integrase core domain HTH_40 PF14493.1 KII68958.1 - 0.062 13.5 0.7 0.14 12.3 0.1 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_11 PF08279.7 KII68958.1 - 0.065 12.8 0.2 0.17 11.5 0.1 1.7 1 0 0 1 1 1 0 HTH domain HTH_7 PF02796.10 KII68958.1 - 0.067 13.0 0.2 0.4 10.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase TrmB PF01978.14 KII68958.1 - 0.098 12.3 0.1 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Rifin_STEVOR PF02009.11 KII68959.1 - 0.0024 17.5 0.9 0.0037 16.9 0.6 1.3 1 0 0 1 1 1 1 Rifin/stevor family DUF3827 PF12877.2 KII68959.1 - 0.048 11.7 1.3 0.069 11.2 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Peptidase_M50 PF02163.17 KII68959.1 - 0.085 11.8 0.2 2.3 7.1 0.1 2.1 2 0 0 2 2 2 0 Peptidase family M50 TMEM154 PF15102.1 KII68959.1 - 0.35 10.5 2.1 0.87 9.2 1.4 1.6 1 0 0 1 1 1 0 TMEM154 protein family Mid2 PF04478.7 KII68959.1 - 0.43 9.9 4.0 0.4 10.0 1.4 1.9 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Lipoprotein_16 PF03923.8 KII68960.1 - 0.00053 19.3 0.5 0.25 10.6 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized lipoprotein CagE_TrbE_VirB PF03135.9 KII68960.1 - 0.004 16.9 3.2 1.2 8.8 0.0 2.4 2 0 0 2 2 2 2 CagE, TrbE, VirB family, component of type IV transporter system DUF2012 PF09430.5 KII68960.1 - 0.043 13.6 3.5 2.4 8.0 0.1 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF2012) SUA5 PF03481.8 KII68969.1 - 0.019 15.0 0.0 0.023 14.7 0.0 1.1 1 0 0 1 1 1 0 Putative GTP-binding controlling metal-binding SRP54 PF00448.17 KII68970.1 - 4.2e-17 62.2 0.0 1.1e-16 60.9 0.0 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54 PF00448.17 KII68971.1 - 3.4e-19 69.0 0.0 5.4e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ArgK PF03308.11 KII68971.1 - 0.00053 18.8 0.0 0.00068 18.4 0.0 1.1 1 0 0 1 1 1 1 ArgK protein Fer4_NifH PF00142.13 KII68971.1 - 0.001 18.3 0.0 0.0017 17.5 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_14 PF13173.1 KII68971.1 - 0.0013 18.6 0.0 0.0033 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KII68971.1 - 0.0015 18.0 0.0 0.0023 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain ArsA_ATPase PF02374.10 KII68971.1 - 0.0025 16.8 0.1 0.0094 15.0 0.0 1.7 2 0 0 2 2 2 1 Anion-transporting ATPase MobB PF03205.9 KII68971.1 - 0.0053 16.4 0.0 0.0089 15.7 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.9 KII68971.1 - 0.0076 15.2 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain AAA_16 PF13191.1 KII68971.1 - 0.027 14.4 0.0 0.067 13.1 0.0 1.6 1 1 1 2 2 2 0 AAA ATPase domain AAA_33 PF13671.1 KII68971.1 - 0.028 14.3 0.1 0.059 13.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KII68971.1 - 0.031 13.8 0.0 0.078 12.5 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Prismane PF03063.15 KII68971.1 - 0.051 11.9 0.0 0.051 11.9 0.0 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family APS_kinase PF01583.15 KII68971.1 - 0.051 13.2 0.0 0.089 12.4 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase PIF1 PF05970.9 KII68971.1 - 0.054 12.4 0.0 0.084 11.8 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase ABC_tran PF00005.22 KII68971.1 - 0.064 13.5 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.1 KII68971.1 - 0.068 12.7 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KII68971.1 - 0.071 12.8 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 KII68971.1 - 0.08 13.0 0.0 0.25 11.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 KII68971.1 - 0.083 12.0 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 KTI12 PF08433.5 KII68971.1 - 0.097 11.8 0.1 0.18 10.9 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 CbiA PF01656.18 KII68971.1 - 0.1 11.9 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.24 KII68971.1 - 0.11 12.6 0.0 0.34 11.1 0.0 1.7 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 KII68971.1 - 0.11 12.0 0.1 0.44 10.1 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Ribosomal_L10 PF00466.15 KII68971.1 - 0.12 12.3 0.1 0.74 9.7 0.0 2.0 1 1 1 2 2 2 0 Ribosomal protein L10 Dynamin_N PF00350.18 KII68973.1 - 2.3e-20 73.0 2.1 1.3e-13 51.0 0.0 2.1 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.18 KII68973.1 - 0.00011 22.1 0.0 0.00016 21.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KII68973.1 - 0.0085 16.5 0.1 0.012 16.0 0.1 1.5 1 1 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 KII68973.1 - 0.076 12.2 0.2 1.2 8.3 0.2 2.3 1 1 0 1 1 1 0 Ferrous iron transport protein B AIG1 PF04548.11 KII68973.1 - 0.078 12.0 1.0 1.6 7.8 0.7 2.2 1 1 0 1 1 1 0 AIG1 family Zeta_toxin PF06414.7 KII68973.1 - 0.086 11.9 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DNA_pol3_a_NII PF11490.3 KII68975.1 - 0.0078 15.8 1.5 0.0078 15.8 1.1 1.6 2 0 0 2 2 2 1 DNA polymerase III polC-type N-terminus II DUF3862 PF12978.2 KII68977.1 - 0.018 14.6 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3862) Kelch_6 PF13964.1 KII68978.1 - 3.1e-25 87.2 16.2 1.2e-05 25.2 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.20 KII68978.1 - 1.9e-20 72.0 16.1 8e-05 22.1 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII68978.1 - 1e-19 69.9 19.9 2.2e-05 24.1 0.0 6.5 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KII68978.1 - 1.1e-16 60.4 7.1 0.0029 17.7 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KII68978.1 - 2.2e-16 59.3 7.8 0.015 15.2 0.4 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.10 KII68978.1 - 1.2e-06 28.0 12.4 1.2 9.0 0.1 6.3 6 0 0 6 6 6 3 Kelch motif zf-C2H2_4 PF13894.1 KII68979.1 - 3.2e-07 30.2 8.1 0.14 12.5 0.0 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 KII68979.1 - 0.00066 19.8 7.4 1.1 9.7 0.0 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.1 KII68979.1 - 0.0016 18.5 0.1 0.029 14.5 0.0 2.8 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-Di19 PF05605.7 KII68979.1 - 0.0096 16.0 0.0 0.031 14.4 0.0 1.8 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 KII68979.1 - 0.01 16.0 12.1 0.83 10.0 0.7 4.1 4 0 0 4 4 4 0 Zinc-finger double domain zf-TRAF PF02176.13 KII68979.1 - 0.017 15.4 5.7 0.057 13.8 1.0 2.4 2 0 0 2 2 2 0 TRAF-type zinc finger zf-met2 PF12907.2 KII68979.1 - 0.086 12.8 1.0 0.24 11.3 0.7 1.8 1 0 0 1 1 1 0 Zinc-binding CHORD PF04968.7 KII68979.1 - 0.74 10.1 3.6 15 5.9 0.1 2.7 1 1 1 2 2 2 0 CHORD AAA PF00004.24 KII68980.1 - 4.7e-09 36.5 0.0 8.8e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KII68980.1 - 1e-05 26.3 0.1 2.4e-05 25.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII68980.1 - 6.2e-05 23.3 0.3 0.00015 22.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain Polyoma_lg_T_C PF06431.6 KII68980.1 - 0.0001 21.1 0.0 0.00014 20.6 0.0 1.2 1 0 0 1 1 1 1 Polyomavirus large T antigen C-terminus AAA_14 PF13173.1 KII68980.1 - 0.00013 21.8 0.0 0.00082 19.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 KII68980.1 - 0.00022 20.4 0.0 0.00041 19.5 0.0 1.4 1 0 0 1 1 1 1 KaiC ABC_tran PF00005.22 KII68980.1 - 0.0011 19.2 0.4 0.021 15.1 0.1 2.2 2 0 0 2 2 2 1 ABC transporter AAA_19 PF13245.1 KII68980.1 - 0.0021 17.7 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 KII68980.1 - 0.0022 16.9 0.0 0.0027 16.6 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein RuvB_N PF05496.7 KII68980.1 - 0.0045 16.0 0.0 0.0065 15.5 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KII68980.1 - 0.0046 17.0 0.3 0.015 15.4 0.2 2.0 1 1 0 1 1 1 1 AAA domain DUF927 PF06048.6 KII68980.1 - 0.0049 16.1 0.0 0.0072 15.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF927) Sigma54_activat PF00158.21 KII68980.1 - 0.0064 15.9 0.0 0.0095 15.4 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.1 KII68980.1 - 0.0067 16.4 0.1 0.097 12.6 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.17 KII68980.1 - 0.0083 16.2 1.0 0.34 11.0 0.0 2.7 2 2 0 2 2 2 1 RNA helicase UPF0079 PF02367.12 KII68980.1 - 0.0097 15.5 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 KII68980.1 - 0.0098 15.5 0.3 0.12 12.0 0.1 2.2 1 1 0 2 2 2 1 NACHT domain NB-ARC PF00931.17 KII68980.1 - 0.011 14.6 0.3 0.029 13.2 0.1 1.7 1 1 1 2 2 2 0 NB-ARC domain AAA_5 PF07728.9 KII68980.1 - 0.011 15.4 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.1 KII68980.1 - 0.012 15.1 0.1 0.032 13.7 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 KII68980.1 - 0.012 15.1 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Sigma54_activ_2 PF14532.1 KII68980.1 - 0.017 15.1 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain MobB PF03205.9 KII68980.1 - 0.019 14.6 0.1 0.037 13.7 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 KII68980.1 - 0.028 13.5 0.0 0.044 12.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Apc9 PF12856.2 KII68980.1 - 0.031 14.3 0.0 0.07 13.2 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 Cytidylate_kin2 PF13189.1 KII68980.1 - 0.032 14.1 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase-like family AAA_30 PF13604.1 KII68980.1 - 0.056 13.0 0.3 0.62 9.6 0.1 2.0 1 1 1 2 2 2 0 AAA domain TIP49 PF06068.8 KII68980.1 - 0.069 11.8 0.2 0.24 10.0 0.0 1.8 2 0 0 2 2 2 0 TIP49 C-terminus AAA_23 PF13476.1 KII68980.1 - 0.093 13.0 1.4 0.22 11.8 0.1 1.9 1 1 1 2 2 2 0 AAA domain DUF87 PF01935.12 KII68980.1 - 2 8.2 5.3 17 5.1 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF87 Pkinase PF00069.20 KII68981.1 - 4.4e-63 212.8 0.0 5.7e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII68981.1 - 1.4e-30 106.2 0.0 1.8e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII68981.1 - 4.8e-09 35.5 0.1 2.3e-07 30.0 0.0 2.1 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.17 KII68981.1 - 0.012 15.0 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 KII68981.1 - 0.039 13.0 0.2 0.06 12.3 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-H2C2_2 PF13465.1 KII68982.1 - 1.7e-06 28.0 14.1 3.5e-05 23.8 0.1 3.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII68982.1 - 5.4e-06 26.3 9.7 0.018 15.3 0.8 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 KII68982.1 - 0.00028 21.0 17.9 0.00029 21.0 1.1 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.1 KII68982.1 - 2 8.7 6.7 21 5.6 0.1 3.5 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.1 KII68983.1 - 6.6e-05 22.9 15.1 0.0098 16.1 0.3 3.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KII68983.1 - 0.0002 21.4 13.7 0.0022 18.1 0.0 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 KII68983.1 - 0.00044 20.4 17.6 0.021 15.1 0.6 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-TRAF PF02176.13 KII68983.1 - 0.0013 19.0 8.8 0.0031 17.8 3.4 2.3 1 1 1 2 2 2 2 TRAF-type zinc finger zf-Di19 PF05605.7 KII68983.1 - 0.003 17.6 1.8 0.0099 15.9 1.3 2.0 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.1 KII68983.1 - 0.0078 16.3 8.1 0.087 13.0 0.0 4.2 4 1 0 4 4 4 1 C2H2-type zinc-finger domain zf-met PF12874.2 KII68983.1 - 1.2 9.4 6.4 22 5.4 0.4 3.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KII68983.1 - 2.9 8.1 8.0 21 5.4 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 KII68985.1 - 0.0032 17.6 11.2 0.059 13.6 0.4 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII68985.1 - 0.014 15.6 0.3 0.014 15.6 0.2 2.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 KII68985.1 - 0.015 15.6 0.7 0.015 15.6 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII68986.1 - 0.00027 21.0 16.1 0.053 13.8 0.5 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 KII68986.1 - 0.023 14.9 0.6 0.023 14.9 0.4 3.9 4 1 0 4 4 4 0 Zinc-finger double domain Rieske PF00355.21 KII68986.1 - 0.046 13.2 2.9 0.099 12.2 2.0 1.6 1 1 0 1 1 1 0 Rieske [2Fe-2S] domain zf-H2C2_5 PF13909.1 KII68986.1 - 0.19 12.0 0.0 0.19 12.0 0.0 4.1 3 2 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.21 KII68986.1 - 1.6 9.2 18.3 0.75 10.2 0.2 3.8 3 1 1 4 4 4 0 Zinc finger, C2H2 type zf-TRAF PF02176.13 KII68986.1 - 1.6 9.1 10.4 5.3 7.5 3.0 2.5 1 1 1 2 2 2 0 TRAF-type zinc finger DUF2681 PF10883.3 KII68987.1 - 0.13 12.4 0.1 0.23 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DDE_3 PF13358.1 KII68988.1 - 0.056 13.1 0.5 0.23 11.1 0.1 1.8 1 1 1 2 2 2 0 DDE superfamily endonuclease rve PF00665.21 KII68992.1 - 7.7e-08 32.4 0.0 2.2e-07 31.0 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain DUF4116 PF13475.1 KII68992.1 - 0.14 11.6 0.7 0.63 9.5 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4116) DUF1759 PF03564.10 KII68994.1 - 1.7e-08 34.3 1.9 6e-08 32.6 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) MIP-T3 PF10243.4 KII68995.1 - 0.29 9.5 65.5 0.33 9.3 45.4 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Peptidase_M14 PF00246.19 KII69002.1 - 8.9e-60 202.6 0.0 1.1e-59 202.3 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF2817 PF10994.3 KII69002.1 - 0.059 12.4 0.0 0.091 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Ribosomal_L44 PF00935.14 KII69003.1 - 3.1 7.8 6.8 0.25 11.3 0.6 2.0 2 0 0 2 2 2 0 Ribosomal protein L44 DUF2877 PF11392.3 KII69004.1 - 0.081 13.1 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2877) IU_nuc_hydro PF01156.14 KII69005.1 - 2.7e-47 161.5 0.0 3.3e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase RE_MamI PF09567.5 KII69005.1 - 0.14 11.1 0.0 0.25 10.3 0.0 1.3 1 0 0 1 1 1 0 MamI restriction endonuclease KAR9 PF08580.5 KII69006.1 - 0.042 12.1 0.6 0.046 12.0 0.4 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Aldo_ket_red PF00248.16 KII69007.1 - 9.9e-16 57.3 0.1 1.2e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Kelch_6 PF13964.1 KII69010.1 - 4e-10 39.4 3.0 0.00026 21.0 0.3 2.1 1 1 1 2 2 2 2 Kelch motif Kelch_5 PF13854.1 KII69010.1 - 3e-09 36.6 0.1 1.8e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII69010.1 - 3.3e-08 32.9 0.5 0.002 17.6 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII69010.1 - 1.7e-07 30.8 0.8 0.0049 16.6 0.1 2.1 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII69010.1 - 1.8e-07 30.6 1.5 0.002 17.8 0.1 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 KII69010.1 - 0.00028 20.9 3.4 0.51 10.5 0.1 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Ribosomal_S14 PF00253.16 KII69010.1 - 0.13 11.6 0.6 0.25 10.7 0.0 1.8 2 1 0 2 2 2 0 Ribosomal protein S14p/S29e rve PF00665.21 KII69011.1 - 1.2e-07 31.8 0.1 7.1e-07 29.3 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.5 KII69011.1 - 0.0013 18.0 0.0 0.0024 17.2 0.0 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger CST-I PF06002.7 KII69013.1 - 0.05 12.8 0.6 0.067 12.4 0.4 1.1 1 0 0 1 1 1 0 Alpha-2,3-sialyltransferase (CST-I) Serpin PF00079.15 KII69014.1 - 1.4e-43 149.4 2.0 1.7e-43 149.2 1.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.21 KII69016.1 - 3.4e-07 30.3 0.1 7.6e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69016.1 - 0.00018 20.9 0.0 0.00038 19.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Herpes_UL92 PF03048.9 KII69017.1 - 1.4 8.4 8.4 0.49 9.9 2.3 2.5 2 0 0 2 2 2 0 UL92 family Ribosomal_L3 PF00297.17 KII69021.1 - 1.9e-19 70.1 0.1 6.9e-19 68.2 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L3 DDE_Tnp_IS1595 PF12762.2 KII69022.1 - 8.2e-14 51.6 0.0 4.3e-13 49.3 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain F-box-like PF12937.2 KII69022.1 - 0.2 11.4 1.8 0.5 10.1 0.1 2.4 2 1 0 2 2 2 0 F-box-like Homeobox PF00046.24 KII69023.1 - 0.00065 19.2 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 Homeobox domain Ribonuclease_3 PF00636.21 KII69024.1 - 3.8e-35 120.7 0.0 4.4e-17 62.5 0.0 2.5 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 KII69024.1 - 2.3e-22 79.3 1.2 2.4e-10 40.4 0.0 4.1 4 0 0 4 4 4 3 Ribonuclease-III-like DUF2042 PF09743.4 KII69025.1 - 7.1e-32 110.7 0.8 9e-32 110.4 0.6 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2042) Ribonuclease_3 PF00636.21 KII69027.1 - 2.5e-29 102.0 0.0 5.3e-17 62.3 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 KII69027.1 - 3.2e-16 59.4 3.9 2.1e-06 27.7 0.4 4.1 3 1 0 3 3 3 3 Ribonuclease-III-like Colicin_im PF03857.8 KII69028.1 - 0.12 12.1 0.1 0.51 10.0 0.1 1.8 1 1 1 2 2 2 0 Colicin immunity protein CpcD PF01383.16 KII69029.1 - 0.05 13.7 0.6 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 CpcD/allophycocyanin linker domain tRNA-synt_1 PF00133.17 KII69030.1 - 2.1e-29 101.9 0.0 7.2e-28 96.9 0.0 2.8 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 KII69030.1 - 2.4e-15 56.5 0.9 6.7e-15 55.1 0.6 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KII69030.1 - 3.2e-15 55.6 0.0 4e-09 35.6 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 KII69030.1 - 1.3e-06 27.7 0.0 3.1e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.1 KII69030.1 - 0.052 12.8 0.0 0.098 11.9 0.0 1.4 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 UPF0565 PF10561.4 KII69031.1 - 0.0083 15.0 0.1 0.0093 14.8 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0565 VWA_2 PF13519.1 KII69031.1 - 0.031 14.4 0.0 0.089 12.8 0.0 1.6 1 1 1 2 2 2 0 von Willebrand factor type A domain Cpn60_TCP1 PF00118.19 KII69032.1 - 7.7e-144 479.9 3.3 8.8e-144 479.7 2.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EGF_2 PF07974.8 KII69033.1 - 0.078 13.1 4.4 0.16 12.1 3.1 1.5 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.2 KII69033.1 - 0.87 9.8 3.5 1.7 8.8 2.4 1.5 1 0 0 1 1 1 0 Human growth factor-like EGF SNAP PF14938.1 KII69034.1 - 2.5e-07 30.1 3.6 5.5e-07 29.0 2.5 1.5 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Clathrin PF00637.15 KII69034.1 - 0.031 13.8 4.5 1.3 8.6 0.1 2.3 1 1 1 2 2 2 0 Region in Clathrin and VPS Zea_mays_MuDR PF05928.6 KII69034.1 - 0.069 12.5 0.5 2.5 7.4 0.1 2.1 1 1 1 2 2 2 0 Zea mays MURB-like protein (MuDR) Foie-gras_1 PF11817.3 KII69034.1 - 0.073 12.5 0.1 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Foie gras liver health family 1 TetR_C_8 PF14278.1 KII69035.1 - 0.16 12.3 0.3 0.16 12.3 0.2 4.8 6 0 0 6 6 6 0 Transcriptional regulator C-terminal region tRNA-synt_1 PF00133.17 KII69039.1 - 0.029 12.3 0.0 0.051 11.5 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) Ferrochelatase PF00762.14 KII69040.1 - 1.3e-76 257.5 0.0 1.9e-76 257.0 0.0 1.2 1 0 0 1 1 1 1 Ferrochelatase DDE_Tnp_IS1595 PF12762.2 KII69043.1 - 1e-10 41.6 0.2 1.3e-10 41.3 0.1 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_Tnp_IS1595 PF12760.2 KII69043.1 - 0.029 14.1 2.6 0.044 13.5 1.8 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Leu_Phe_trans PF03588.9 KII69043.1 - 0.11 11.6 0.4 0.18 10.9 0.3 1.4 1 1 0 1 1 1 0 Leucyl/phenylalanyl-tRNA protein transferase COesterase PF00135.23 KII69046.1 - 0.047 12.4 0.7 0.071 11.8 0.5 1.3 1 0 0 1 1 1 0 Carboxylesterase family Flu_B_M2 PF04772.7 KII69046.1 - 0.19 11.7 1.6 0.3 11.1 1.1 1.2 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) AAA_15 PF13175.1 KII69049.1 - 0.025 13.6 0.8 0.029 13.4 0.6 1.2 1 0 0 1 1 1 0 AAA ATPase domain Vmethyltransf_C PF08456.5 KII69049.1 - 0.1 12.0 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Viral methyltransferase C-terminal ETRAMP PF09716.5 KII69050.1 - 0.013 15.4 0.0 0.052 13.5 0.0 2.0 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) ATG27 PF09451.5 KII69050.1 - 0.027 13.6 0.0 0.062 12.5 0.0 1.5 2 0 0 2 2 2 0 Autophagy-related protein 27 DUF3899 PF13038.1 KII69050.1 - 0.035 14.2 0.2 0.12 12.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF2370 PF10176.4 KII69050.1 - 0.045 13.0 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF912 PF06024.7 KII69050.1 - 0.045 13.7 0.0 0.045 13.7 0.0 2.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) CT47 PF15623.1 KII69050.1 - 0.67 9.6 12.7 0.95 9.1 8.8 1.1 1 0 0 1 1 1 0 Cancer/testis gene family 47 IncA PF04156.9 KII69050.1 - 2.5 7.6 4.5 5.8 6.4 3.1 1.6 1 0 0 1 1 1 0 IncA protein DUF1410 PF07198.6 KII69052.1 - 0.049 13.9 0.5 0.15 12.4 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1410) DUF2370 PF10176.4 KII69054.1 - 0.00048 19.5 0.0 0.00081 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) DUF912 PF06024.7 KII69054.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Herpes_gE PF02480.11 KII69054.1 - 0.039 12.2 0.0 0.066 11.4 0.0 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF2807 PF10988.3 KII69054.1 - 0.052 13.0 0.2 0.079 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2807) PBP1_TM PF14812.1 KII69054.1 - 0.054 13.7 2.3 0.14 12.4 1.6 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3060 PF11259.3 KII69054.1 - 0.11 12.1 0.1 0.99 9.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) DUF912 PF06024.7 KII69055.1 - 1.7e-05 24.7 3.0 6.2e-05 22.9 2.1 2.1 1 1 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) ATG27 PF09451.5 KII69055.1 - 0.00051 19.3 0.0 0.00084 18.6 0.0 1.3 1 0 0 1 1 1 1 Autophagy-related protein 27 DUF2370 PF10176.4 KII69055.1 - 0.00063 19.1 0.2 0.00097 18.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) DUF2207 PF09972.4 KII69055.1 - 0.002 16.7 1.1 0.0045 15.6 0.0 1.9 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) DUF4448 PF14610.1 KII69055.1 - 0.0022 17.4 0.0 0.0042 16.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) SID-1_RNA_chan PF13965.1 KII69055.1 - 0.0044 15.2 0.3 0.0056 14.9 0.2 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Lamp PF01299.12 KII69055.1 - 0.0049 16.0 0.1 0.013 14.6 0.0 1.8 2 0 0 2 2 2 1 Lysosome-associated membrane glycoprotein (Lamp) Sec62 PF03839.11 KII69055.1 - 0.0088 15.4 2.4 0.018 14.4 1.6 1.4 1 0 0 1 1 1 1 Translocation protein Sec62 CDC45 PF02724.9 KII69055.1 - 0.024 12.7 5.0 0.031 12.3 3.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.17 KII69055.1 - 0.031 13.3 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2062 PF09835.4 KII69055.1 - 0.039 13.5 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) DUF1506 PF07405.6 KII69055.1 - 0.039 13.9 1.1 0.059 13.3 0.1 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1506) GAGA_bind PF06217.7 KII69055.1 - 0.044 13.7 0.4 0.062 13.2 0.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Herpes_gE PF02480.11 KII69055.1 - 0.08 11.2 0.2 0.17 10.1 0.0 1.6 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E UPF0233 PF06781.7 KII69055.1 - 0.085 12.4 0.5 0.33 10.5 0.4 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0233) Daxx PF03344.10 KII69055.1 - 0.28 9.6 15.7 0.38 9.1 10.9 1.1 1 0 0 1 1 1 0 Daxx Family Trypan_PARP PF05887.6 KII69055.1 - 2.7 7.8 11.8 4.4 7.1 8.2 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) YqfQ PF14181.1 KII69055.1 - 2.9 7.9 10.0 5 7.1 7.0 1.3 1 0 0 1 1 1 0 YqfQ-like protein I-set PF07679.11 KII69056.1 - 3.5e-11 42.8 0.0 4.8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.1 KII69056.1 - 4.7e-06 26.6 0.0 6.6e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.1 KII69056.1 - 2.4e-05 24.7 0.5 4.1e-05 24.0 0.3 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.12 KII69056.1 - 0.00072 19.4 0.1 0.0043 16.9 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.20 KII69056.1 - 0.026 14.6 0.4 0.089 12.9 0.3 1.8 1 1 0 1 1 1 0 Immunoglobulin domain DUF4087 PF13316.1 KII69056.1 - 0.12 12.5 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4087) Laminin_G_3 PF13385.1 KII69057.1 - 2.7e-09 37.4 0.2 4.2e-09 36.8 0.1 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PAN_2 PF08276.6 KII69057.1 - 0.00051 19.8 7.1 0.0012 18.5 5.0 1.7 1 0 0 1 1 1 1 PAN-like domain PAN_4 PF14295.1 KII69057.1 - 0.01 15.5 1.6 0.01 15.5 1.1 1.8 2 0 0 2 2 2 0 PAN domain Pentaxin PF00354.12 KII69057.1 - 0.11 11.9 1.8 0.29 10.5 0.0 2.2 3 0 0 3 3 3 0 Pentaxin family MANEC PF07502.9 KII69057.1 - 2.3 8.2 17.6 3.9 7.5 4.5 2.5 1 1 1 2 2 2 0 MANEC domain DDE_Tnp_IS1595 PF12762.2 KII69060.1 - 5.2e-07 29.6 0.0 5.8e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Herpes_UL52 PF03121.10 KII69062.1 - 0.11 12.2 1.1 7.6 6.3 0.1 2.9 2 0 0 2 2 2 0 Herpesviridae UL52/UL70 DNA primase Pentapeptide_4 PF13599.1 KII69062.1 - 0.27 11.0 3.9 2.9 7.7 0.0 3.2 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) RVT_1 PF00078.22 KII69063.1 - 1.9e-11 43.7 0.1 3.3e-11 42.9 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2191 PF09957.4 KII69063.1 - 0.059 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2191) TerY-C PF15616.1 KII69064.1 - 0.014 15.3 0.7 0.02 14.7 0.5 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain rve PF00665.21 KII69065.1 - 6.2e-18 65.0 0.0 1e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69065.1 - 1.2e-05 24.6 0.1 3.6e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain UN_NPL4 PF11543.3 KII69065.1 - 0.064 13.5 0.1 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 tRNA_m1G_MT PF01746.16 KII69065.1 - 0.099 12.2 0.3 0.44 10.1 0.1 1.9 1 1 0 2 2 2 0 tRNA (Guanine-1)-methyltransferase Glyco_transf_10 PF00852.14 KII69068.1 - 8.3e-41 139.7 8.5 9.9e-41 139.4 5.9 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) Cauli_AT PF03233.8 KII69068.1 - 0.061 13.0 6.9 1.6 8.4 0.2 3.0 1 1 3 4 4 4 0 Aphid transmission protein TPR_2 PF07719.12 KII69070.1 - 0.00018 21.1 0.6 0.0053 16.5 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII69070.1 - 0.041 13.4 0.8 0.12 11.9 0.6 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII69070.1 - 0.051 13.3 0.2 0.19 11.5 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat rve PF00665.21 KII69071.1 - 3.5e-24 85.2 0.1 3.9e-24 85.0 0.1 1.0 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69071.1 - 3.1e-07 29.8 0.1 5.7e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII69071.1 - 0.0036 17.2 0.0 0.0042 17.0 0.0 1.1 1 0 0 1 1 1 1 DDE domain NOC3p PF07540.6 KII69072.1 - 0.0003 21.0 0.0 0.00042 20.5 0.0 1.2 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.12 KII69073.1 - 1.4e-16 60.3 0.4 3e-16 59.2 0.1 1.6 1 1 1 2 2 2 1 CBF/Mak21 family TPK_catalytic PF04263.11 KII69075.1 - 1.1e-22 79.9 0.0 1.8e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.9 KII69075.1 - 7.1e-14 51.2 0.0 1.3e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Evr1_Alr PF04777.8 KII69076.1 - 1.2e-15 57.1 0.0 1.9e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Erv1 / Alr family Zn-ribbon_8 PF09723.5 KII69076.1 - 0.71 9.8 3.4 5.7 6.9 0.4 2.3 2 0 0 2 2 2 0 Zinc ribbon domain Thioredoxin PF00085.15 KII69077.1 - 9.3e-16 57.4 0.2 1.4e-15 56.8 0.2 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 KII69077.1 - 0.00012 22.1 2.6 0.00046 20.2 1.8 2.2 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KII69077.1 - 0.00042 20.4 1.9 0.00082 19.5 1.3 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KII69077.1 - 0.00075 19.4 0.1 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 KII69077.1 - 0.0018 17.9 0.1 0.003 17.2 0.1 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KII69077.1 - 0.026 14.0 0.1 0.16 11.5 0.1 2.0 2 0 0 2 2 2 0 Redoxin NTP_transferase PF00483.18 KII69078.1 - 4.6e-13 49.0 0.0 6.2e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 KII69078.1 - 2.1e-06 27.9 0.0 2.7e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain H2TH PF06831.9 KII69079.1 - 0.095 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain SUZ PF12752.2 KII69080.1 - 0.00017 22.0 0.0 0.00017 22.0 0.0 2.1 3 0 0 3 3 3 1 SUZ domain DUF462 PF04315.7 KII69080.1 - 0.0037 16.6 0.3 0.0052 16.1 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF462 R3H PF01424.17 KII69080.1 - 0.011 15.4 0.0 0.033 13.8 0.0 1.8 1 0 0 1 1 1 0 R3H domain Na_trans_assoc PF06512.8 KII69080.1 - 0.026 14.5 5.3 0.042 13.8 3.7 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated Zn_ribbon_2 PF12674.2 KII69080.1 - 0.049 13.9 0.7 1 9.7 0.0 2.5 2 0 0 2 2 2 0 Putative zinc ribbon domain Beta-lactamase2 PF13354.1 KII69080.1 - 0.098 12.0 0.0 0.24 10.8 0.0 1.6 1 1 0 1 1 1 0 Beta-lactamase enzyme family DDE_Tnp_IS1595 PF12762.2 KII69081.1 - 0.00044 20.1 0.4 0.027 14.3 0.1 2.1 1 1 1 2 2 2 2 ISXO2-like transposase domain HTH_Tnp_Tc3_1 PF11427.3 KII69083.1 - 0.00066 19.2 0.0 0.0014 18.1 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase HTH_Tnp_Tc3_2 PF01498.13 KII69083.1 - 0.0022 17.9 0.3 0.0045 17.0 0.1 1.6 2 0 0 2 2 2 1 Transposase CRT10 PF08728.5 KII69083.1 - 0.023 12.7 1.5 0.022 12.7 1.0 1.0 1 0 0 1 1 1 0 CRT10 HTH_29 PF13551.1 KII69083.1 - 0.047 13.8 0.0 0.068 13.3 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix GerE PF00196.14 KII69083.1 - 0.083 12.2 0.4 10 5.5 0.0 2.8 3 0 0 3 3 3 0 Bacterial regulatory proteins, luxR family zf-H2C2_2 PF13465.1 KII69084.1 - 2.3e-11 43.3 24.5 3.3e-07 30.2 0.4 5.1 5 0 0 5 5 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 KII69084.1 - 2.6e-05 24.2 26.6 0.00023 21.3 1.3 5.1 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII69084.1 - 0.00014 21.9 1.0 0.00014 21.9 0.7 5.0 5 0 0 5 5 5 1 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KII69084.1 - 0.00048 19.9 12.4 0.15 12.0 1.1 3.8 4 0 0 4 4 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII69084.1 - 0.00051 20.1 1.4 0.46 10.6 0.1 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 KII69084.1 - 0.0018 18.3 7.2 0.058 13.5 1.6 3.2 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) GAGA PF09237.6 KII69084.1 - 0.0046 16.5 0.2 0.16 11.5 0.1 2.5 2 0 0 2 2 2 1 GAGA factor zf-met PF12874.2 KII69084.1 - 0.023 14.8 11.5 0.084 13.1 0.4 3.2 4 0 0 4 4 3 0 Zinc-finger of C2H2 type DUF629 PF04780.7 KII69084.1 - 0.027 13.0 4.4 0.14 10.6 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Rad50_zn_hook PF04423.9 KII69084.1 - 0.11 11.9 0.9 5 6.6 0.0 2.9 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-Di19 PF05605.7 KII69084.1 - 0.15 12.1 12.1 0.27 11.3 0.6 2.9 3 0 0 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.11 KII69084.1 - 0.31 10.9 8.5 3.2 7.7 0.2 3.0 2 1 0 2 2 2 0 AN1-like Zinc finger zf-MIZ PF02891.15 KII69084.1 - 0.32 10.5 5.6 5.3 6.6 0.1 3.3 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger Elf1 PF05129.8 KII69084.1 - 0.36 10.5 9.2 3 7.6 0.6 3.7 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like zf-C3HC4_3 PF13920.1 KII69084.1 - 0.37 10.4 4.1 11 5.8 0.1 3.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.6 KII69084.1 - 0.41 10.3 4.6 0.39 10.4 1.8 1.9 2 1 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) DUF2225 PF09986.4 KII69084.1 - 0.64 9.4 3.6 11 5.3 0.5 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-RING_3 PF14369.1 KII69084.1 - 5.2 7.1 8.6 8 6.5 0.0 3.7 4 0 0 4 4 3 0 zinc-finger Zn-ribbon_8 PF09723.5 KII69084.1 - 9.4 6.2 9.6 12 5.9 0.0 3.2 4 0 0 4 4 3 0 Zinc ribbon domain DUF2228 PF10228.4 KII69085.1 - 0.98 8.9 4.4 0.18 11.3 0.3 1.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) G-alpha PF00503.15 KII69086.1 - 1.5e-81 274.0 0.2 1.9e-81 273.7 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KII69086.1 - 7.8e-15 54.5 0.4 1.9e-11 43.5 0.0 2.9 3 1 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KII69086.1 - 0.00028 20.1 1.4 0.11 11.5 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_33 PF13671.1 KII69086.1 - 0.018 14.9 0.0 0.066 13.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 KII69086.1 - 0.021 14.3 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.22 KII69086.1 - 0.022 14.1 0.0 0.24 10.8 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 KII69086.1 - 0.024 15.4 0.2 0.13 13.1 0.2 2.1 2 1 0 2 2 2 0 AAA domain DUF3713 PF12506.3 KII69086.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) DUF87 PF01935.12 KII69086.1 - 0.085 12.6 0.9 0.24 11.1 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function DUF87 DUF3666 PF12408.3 KII69086.1 - 0.1 11.7 1.1 0.65 9.1 0.1 2.5 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase FtsK_SpoIIIE PF01580.13 KII69086.1 - 0.13 11.6 0.0 0.59 9.5 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.22 KII69086.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Ribul_P_3_epim PF00834.14 KII69088.1 - 4.1e-36 123.9 0.2 5e-36 123.7 0.1 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.14 KII69088.1 - 0.0023 17.4 0.0 0.0031 17.0 0.0 1.3 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.16 KII69088.1 - 0.02 14.1 0.1 0.03 13.6 0.1 1.3 1 1 0 1 1 1 0 Histidine biosynthesis protein OMPdecase PF00215.19 KII69088.1 - 0.054 12.8 0.1 0.14 11.5 0.0 1.6 1 1 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family IGPS PF00218.16 KII69088.1 - 0.1 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase FeoA PF04023.9 KII69089.1 - 0.03 14.2 0.1 0.042 13.8 0.0 1.3 1 1 0 1 1 1 0 FeoA domain Choline_kinase PF01633.15 KII69091.1 - 2.3e-21 76.3 0.1 5.6e-21 75.0 0.1 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 KII69091.1 - 1.3e-08 34.9 0.0 1.8e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family TRAM_LAG1_CLN8 PF03798.11 KII69092.1 - 0.00016 21.2 9.6 0.00019 21.0 6.6 1.1 1 0 0 1 1 1 1 TLC domain DUF3112 PF11309.3 KII69092.1 - 0.17 11.7 6.6 0.12 12.1 3.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) TRIQK PF15168.1 KII69092.1 - 2.1 8.3 6.7 0.49 10.3 0.8 2.2 1 1 1 2 2 2 0 Triple QxxK/R motif-containing protein family SUR7 PF06687.7 KII69092.1 - 4.4 6.8 7.3 6.6 6.2 5.1 1.2 1 0 0 1 1 1 0 SUR7/PalI family MscL PF01741.13 KII69092.1 - 9.6 6.3 9.2 1.4 9.0 3.1 1.8 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL UDPGP PF01704.13 KII69093.1 - 1.3e-31 109.5 0.0 1.5e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 KII69093.1 - 0.022 14.8 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain PRP3 PF08572.5 KII69094.1 - 3.6e-60 203.1 5.3 7.9e-60 202.0 3.7 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 KII69094.1 - 2.4e-25 88.6 0.6 6.7e-25 87.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Pex14_N PF04695.8 KII69094.1 - 0.041 13.9 5.2 0.2 11.7 1.2 2.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CAF1 PF04857.15 KII69095.1 - 9.3e-10 38.2 1.0 1.1e-09 38.0 0.6 1.3 1 1 0 1 1 1 1 CAF1 family ribonuclease HTH_Tnp_IS630 PF01710.11 KII69095.1 - 0.003 17.2 1.4 0.0068 16.0 1.0 1.6 1 0 0 1 1 1 1 Transposase s48_45 PF07422.8 KII69095.1 - 0.0045 17.0 3.9 0.0045 17.0 2.7 1.7 2 0 0 2 2 2 1 Sexual stage antigen s48/45 domain Hexapep PF00132.19 KII69096.1 - 1.7e-07 30.3 26.8 0.00022 20.5 4.6 4.0 1 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.7 KII69096.1 - 0.026 13.0 0.5 0.045 12.3 0.4 1.5 1 0 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.1 KII69096.1 - 0.04 13.4 25.2 0.32 10.5 7.8 3.8 2 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase W2 PF02020.13 KII69096.1 - 0.046 13.6 0.1 0.15 12.0 0.1 1.8 1 0 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.18 KII69096.1 - 0.12 11.6 0.0 0.31 10.3 0.0 1.7 2 0 0 2 2 2 0 Nucleotidyl transferase GTP_EFTU PF00009.22 KII69097.1 - 5.4e-35 120.5 0.2 9e-35 119.8 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 KII69097.1 - 2.9e-07 30.4 2.2 3.1e-07 30.4 0.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KII69097.1 - 2.8e-06 27.2 0.0 6.8e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KII69097.1 - 3.2e-06 26.4 0.5 1.1e-05 24.7 0.4 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU_D4 PF14578.1 KII69097.1 - 0.00027 20.4 2.4 0.00038 20.0 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 4 PduV-EutP PF10662.4 KII69097.1 - 0.0033 16.9 0.2 0.37 10.2 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.12 KII69097.1 - 0.009 15.5 1.1 2.6 7.5 0.1 2.9 2 1 0 2 2 2 2 Conserved hypothetical ATP binding protein MobB PF03205.9 KII69097.1 - 0.034 13.8 0.8 1.5 8.5 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B WD40 PF00400.27 KII69099.1 - 2.2e-20 71.7 7.4 4.5e-10 39.0 0.3 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KII69099.1 - 0.0035 16.1 0.2 0.083 11.6 0.0 2.0 1 1 1 2 2 2 2 Nup133 N terminal like CTP_transf_2 PF01467.21 KII69100.1 - 3.6e-05 23.8 0.1 7e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Cytidylyltransferase RL11D PF11088.3 KII69101.1 - 0.078 12.7 0.1 0.96 9.2 0.0 2.1 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 UCH PF00443.24 KII69101.1 - 0.084 11.9 1.8 0.11 11.6 1.3 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase V-ATPase_G PF03179.10 KII69103.1 - 3.3e-22 78.7 11.5 3.7e-22 78.6 7.9 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit GrpE PF01025.14 KII69103.1 - 0.02 14.4 8.0 0.024 14.1 5.5 1.2 1 0 0 1 1 1 0 GrpE Peptidase_S46 PF10459.4 KII69103.1 - 0.02 13.3 3.0 0.023 13.1 2.1 1.0 1 0 0 1 1 1 0 Peptidase S46 ParBc PF02195.13 KII69103.1 - 0.068 13.2 3.0 1.1 9.4 0.2 2.2 1 1 1 2 2 2 0 ParB-like nuclease domain tRNA-synt_1c PF00749.16 KII69103.1 - 0.082 11.5 2.6 0.11 11.1 1.8 1.3 1 1 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain HrpE PF06188.7 KII69103.1 - 0.093 12.4 4.2 0.12 12.0 2.9 1.1 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E GA PF01468.12 KII69103.1 - 0.19 11.8 1.6 1 9.5 0.5 2.3 1 1 1 2 2 2 0 GA module RapA_C PF12137.3 KII69103.1 - 0.27 10.0 7.1 0.32 9.7 5.0 1.2 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Mg_chelatase_2 PF13335.1 KII69103.1 - 0.29 11.5 4.4 0.49 10.8 2.8 1.6 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI Orthopox_A5L PF06193.6 KII69103.1 - 0.29 11.0 5.1 0.4 10.6 3.5 1.2 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like ERM PF00769.14 KII69103.1 - 0.34 10.4 13.6 0.41 10.1 9.4 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF826 PF05696.6 KII69103.1 - 0.36 10.9 2.7 0.41 10.8 1.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF826) DUF883 PF05957.8 KII69103.1 - 0.38 11.1 9.9 1.5 9.2 4.3 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) HTH_40 PF14493.1 KII69103.1 - 0.46 10.7 5.7 0.72 10.1 1.7 2.2 1 1 1 2 2 2 0 Helix-turn-helix domain DUF4220 PF13968.1 KII69103.1 - 0.56 9.2 2.3 0.64 9.0 1.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Lge1 PF11488.3 KII69103.1 - 0.69 10.1 4.2 1.2 9.3 2.6 1.7 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 Mnd1 PF03962.10 KII69103.1 - 0.72 9.4 8.4 0.94 9.1 5.8 1.2 1 0 0 1 1 1 0 Mnd1 family HAUS6_N PF14661.1 KII69103.1 - 0.81 8.9 5.6 0.91 8.8 3.9 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Macoilin PF09726.4 KII69103.1 - 1.1 7.4 8.6 1.2 7.2 6.0 1.0 1 0 0 1 1 1 0 Transmembrane protein HSCB_C PF07743.8 KII69103.1 - 2.1 8.8 11.1 2.2 8.7 1.3 2.2 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain DUF1104 PF06518.6 KII69103.1 - 3 8.0 9.4 19 5.4 6.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1104) IncA PF04156.9 KII69103.1 - 3.1 7.3 8.9 3.9 7.0 6.2 1.2 1 0 0 1 1 1 0 IncA protein ATP-synt_B PF00430.13 KII69103.1 - 8.3 6.2 16.7 57 3.5 11.6 1.9 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) eIF-5_eIF-2B PF01873.12 KII69104.1 - 1e-35 122.0 0.5 1.2e-35 121.9 0.3 1.0 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.7 KII69104.1 - 0.01 15.1 0.3 0.017 14.4 0.2 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Elf1 PF05129.8 KII69104.1 - 0.038 13.6 0.9 0.062 12.9 0.6 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-CHY PF05495.7 KII69104.1 - 0.082 13.0 0.6 0.13 12.4 0.4 1.4 1 0 0 1 1 1 0 CHY zinc finger zinc_ribbon_4 PF13717.1 KII69104.1 - 0.093 12.4 1.7 3.5 7.3 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 KII69104.1 - 0.11 12.1 1.7 3.7 7.2 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 KII69104.1 - 0.21 11.4 1.7 8.4 6.2 0.1 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 KII69104.1 - 0.37 10.6 2.8 1.4 8.7 1.9 1.9 1 1 0 1 1 1 0 PhnA Zinc-Ribbon TFIIS_C PF01096.13 KII69104.1 - 1 9.0 3.8 45 3.7 2.7 2.2 1 1 1 2 2 2 0 Transcription factor S-II (TFIIS) GETHR PF05671.6 KII69105.1 - 0.26 10.4 56.2 8.4 5.6 0.2 10.9 11 0 0 11 11 11 0 GETHR pentapeptide repeat (5 copies) DUF367 PF04034.8 KII69106.1 - 2.1e-36 124.3 0.0 2.9e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF367) CoatB PF10389.4 KII69106.1 - 0.025 14.4 0.1 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage coat protein B Tubulin PF00091.20 KII69107.1 - 2.2e-65 220.5 0.0 3.5e-65 219.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KII69107.1 - 4e-37 127.0 0.4 8.5e-37 126.0 0.3 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 KII69107.1 - 1.5e-06 28.2 0.0 2.6e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 KII69107.1 - 0.00016 21.2 0.0 0.00031 20.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain NPHI_C PF08469.5 KII69108.1 - 0.063 13.1 0.1 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 Nucleoside triphosphatase I C-terminal XAP5 PF04921.9 KII69109.1 - 0.085 12.4 0.2 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 XAP5, circadian clock regulator RRM_5 PF13893.1 KII69110.1 - 6.3e-06 25.9 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII69110.1 - 0.0018 17.8 0.0 0.0036 16.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII69110.1 - 0.026 14.4 0.0 0.1 12.6 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) AT_hook PF02178.14 KII69110.1 - 0.063 12.9 8.1 0.23 11.2 5.6 2.1 1 0 0 1 1 1 0 AT hook motif Asp-B-Hydro_N PF05279.6 KII69110.1 - 7.1 6.4 12.8 9.9 5.9 8.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF155 PF02582.9 KII69111.1 - 1.8e-16 60.5 0.2 2.4e-16 60.1 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Mononeg_mRNAcap PF14318.1 KII69111.1 - 0.022 13.7 0.3 0.075 12.0 0.0 1.8 2 0 0 2 2 2 0 Mononegavirales mRNA-capping region V Evr1_Alr PF04777.8 KII69112.1 - 9e-27 92.8 0.0 1.4e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Erv1 / Alr family zf-H2C2_2 PF13465.1 KII69112.1 - 0.43 10.9 4.3 0.49 10.7 0.0 2.7 2 1 0 2 2 2 0 Zinc-finger double domain LSM PF01423.17 KII69113.1 - 6.6e-16 57.6 0.6 9.3e-16 57.1 0.4 1.2 1 0 0 1 1 1 1 LSM domain DUF3247 PF11607.3 KII69113.1 - 0.0018 18.4 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3247) Gemin7 PF11095.3 KII69113.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) SM-ATX PF14438.1 KII69113.1 - 0.08 12.8 0.1 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain zf-ZPR1 PF03367.8 KII69116.1 - 8.4e-50 168.0 7.9 1.1e-38 131.8 0.2 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Dehyd-heme_bind PF09098.5 KII69116.1 - 0.014 14.8 0.1 0.044 13.2 0.1 1.9 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding DZR PF12773.2 KII69116.1 - 0.057 13.2 6.1 0.77 9.6 0.5 2.8 2 2 0 2 2 2 0 Double zinc ribbon TIG PF01833.19 KII69116.1 - 0.15 12.0 0.4 0.6 10.1 0.0 2.0 2 0 0 2 2 2 0 IPT/TIG domain Cytochrome_C554 PF13435.1 KII69116.1 - 0.33 11.0 7.5 0.16 12.0 2.2 2.1 2 0 0 2 2 2 0 Cytochrome c554 and c-prime DUF3716 PF12511.3 KII69116.1 - 1.3 8.7 5.8 8.3 6.0 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) Ribosomal_L32p PF01783.18 KII69116.1 - 1.4 9.1 3.7 3.7 7.7 0.9 2.7 2 1 0 2 2 2 0 Ribosomal L32p protein family UPF0547 PF10571.4 KII69116.1 - 1.4 8.6 8.6 4 7.2 0.2 3.1 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 DUF876 PF05936.7 KII69118.1 - 2.6e-28 98.6 0.0 3.7e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF876) DUF2077 PF09850.4 KII69118.1 - 5.4e-24 84.7 0.0 7.4e-24 84.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2077) DUF2345 PF10106.4 KII69120.1 - 4.9e-41 139.9 1.1 4.9e-41 139.9 0.8 1.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2345) T6SS_Vgr PF13296.1 KII69120.1 - 1.1e-32 112.0 2.5 1.1e-32 112.0 1.7 2.1 2 0 0 2 2 2 1 Putative type VI secretion system Rhs element Vgr DSBA PF01323.15 KII69120.1 - 0.064 12.7 0.5 0.096 12.2 0.3 1.3 1 0 0 1 1 1 0 DSBA-like thioredoxin domain DUF3828 PF12883.2 KII69121.1 - 6.4e-21 74.4 0.4 7.9e-21 74.1 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3828) TpcC PF12642.2 KII69121.1 - 0.018 14.6 0.3 0.024 14.1 0.2 1.3 1 0 0 1 1 1 0 Conjugative transposon protein TcpC SLT PF01464.15 KII69122.1 - 0.0066 15.9 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 Transglycosylase SLT domain VCBS PF13517.1 KII69123.1 - 0.035 14.4 0.1 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII69123.1 - 0.075 12.7 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 FG-GAP repeat PolyA_pol PF01743.15 KII69124.1 - 4e-30 104.6 0.1 6.7e-30 103.8 0.1 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 KII69124.1 - 4e-09 35.9 0.0 1.1e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A DDE_Tnp_IS1595 PF12762.2 KII69125.1 - 2.2e-12 47.0 0.2 4.8e-12 45.9 0.0 1.6 1 1 1 2 2 2 1 ISXO2-like transposase domain Lactamase_B PF00753.22 KII69126.1 - 3.6e-08 33.2 0.0 4.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KII69126.1 - 0.0013 18.2 0.0 0.0015 18.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PDEase_II PF02112.10 KII69126.1 - 0.0081 15.1 0.1 0.0091 14.9 0.0 1.2 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II TFIID_30kDa PF03540.8 KII69127.1 - 6.9e-15 54.6 0.0 1.1e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Ribosomal_60s PF00428.14 KII69127.1 - 0.13 12.7 0.2 0.41 11.0 0.0 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein PilO PF04350.8 KII69128.1 - 0.034 14.0 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 Pilus assembly protein, PilO DDE_Tnp_IS1595 PF12762.2 KII69129.1 - 0.038 13.8 0.0 0.35 10.7 0.0 2.1 1 1 0 1 1 1 0 ISXO2-like transposase domain RRM_1 PF00076.17 KII69132.1 - 1.2e-16 60.0 0.0 2.6e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII69132.1 - 3.5e-13 49.3 0.0 6.9e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII69132.1 - 1.1e-10 41.2 0.0 2e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 KII69132.1 - 0.047 13.4 0.2 0.24 11.1 0.0 2.3 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif CbiA PF01656.18 KII69133.1 - 7.6e-35 120.0 0.0 1e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 KII69133.1 - 1.4e-07 31.5 0.0 0.0002 21.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain MerR PF00376.18 KII69133.1 - 4.2e-05 23.0 0.0 9.6e-05 21.8 0.0 1.6 1 0 0 1 1 1 1 MerR family regulatory protein ArsA_ATPase PF02374.10 KII69133.1 - 0.00027 20.1 0.4 0.024 13.6 0.1 2.2 2 0 0 2 2 2 2 Anion-transporting ATPase MipZ PF09140.6 KII69133.1 - 0.00063 18.8 0.3 0.052 12.6 0.0 2.2 2 0 0 2 2 2 1 ATPase MipZ VirC1 PF07015.6 KII69133.1 - 0.0084 15.2 0.0 3.8 6.5 0.0 2.3 2 0 0 2 2 2 2 VirC1 protein HTH_31 PF13560.1 KII69133.1 - 0.014 15.6 0.6 0.036 14.2 0.2 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain MerR_1 PF13411.1 KII69133.1 - 0.016 14.9 0.0 0.049 13.4 0.0 1.8 1 1 0 1 1 1 0 MerR HTH family regulatory protein HTH_AraC PF00165.18 KII69133.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family ParBc PF02195.13 KII69134.1 - 4e-09 36.4 0.0 7.9e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 ParB-like nuclease domain Lysis_col PF02402.11 KII69135.1 - 0.079 12.5 4.8 1.4 8.5 0.1 3.7 4 0 0 4 4 4 0 Lysis protein Sec1 PF00995.18 KII69136.1 - 6.7e-76 256.1 11.0 7.7e-76 255.9 7.6 1.0 1 0 0 1 1 1 1 Sec1 family PsbQ PF05757.6 KII69136.1 - 0.033 13.5 0.1 0.057 12.8 0.1 1.3 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) DnaJ PF00226.26 KII69137.1 - 1.3e-20 72.8 2.8 1.3e-20 72.8 2.0 2.0 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.23 KII69137.1 - 2.2e-10 39.6 0.4 0.00076 18.9 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 KII69137.1 - 9.9e-08 31.5 0.3 8.1e-07 28.6 0.1 2.5 2 1 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KII69137.1 - 1.2e-07 31.0 0.1 0.0049 16.6 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KII69137.1 - 1e-05 25.7 1.5 0.0015 18.7 0.0 3.7 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII69137.1 - 6.8e-05 22.3 0.3 0.007 16.0 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 KII69137.1 - 7.4e-05 22.8 1.9 0.00014 21.9 0.6 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 KII69137.1 - 8.4e-05 22.3 3.4 0.41 10.5 0.0 4.2 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.1 KII69137.1 - 0.00017 21.4 0.3 0.00083 19.2 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KII69137.1 - 0.00034 20.9 0.0 0.33 11.6 0.0 3.8 4 1 1 5 5 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 KII69137.1 - 0.00038 20.2 0.0 0.00095 18.9 0.0 1.7 2 0 0 2 2 1 1 Tetratricopeptide repeat NARP1 PF12569.3 KII69137.1 - 0.001 17.9 5.6 0.0019 17.0 0.1 2.2 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_16 PF13432.1 KII69137.1 - 0.0015 19.1 0.0 0.031 14.9 0.0 2.7 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_21 PF09976.4 KII69137.1 - 0.041 13.8 1.8 0.28 11.1 0.0 2.6 2 2 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 KII69137.1 - 0.042 14.0 0.4 4.8 7.6 0.0 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat FlbT PF07378.6 KII69137.1 - 0.21 11.4 2.5 0.22 11.3 0.2 2.1 3 0 0 3 3 3 0 Flagellar protein FlbT Lipoprotein_7 PF01540.11 KII69137.1 - 0.27 10.2 4.3 0.074 12.1 1.0 1.5 2 0 0 2 2 2 0 Adhesin lipoprotein TPR_6 PF13174.1 KII69137.1 - 0.97 10.0 3.4 14 6.4 0.0 3.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII69138.1 - 6.1e-16 57.8 1.0 5.5e-08 32.3 0.2 3.1 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.1 KII69138.1 - 1.2e-12 46.9 3.0 4.2e-05 23.4 0.1 2.9 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KII69138.1 - 9.4e-11 40.8 3.5 3.2e-06 26.4 0.2 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII69138.1 - 8.2e-10 37.8 3.8 8.4e-05 22.1 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KII69138.1 - 8.8e-08 32.6 0.1 0.026 15.1 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII69138.1 - 3.4e-07 29.5 3.5 0.0001 21.8 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 KII69138.1 - 6.9e-06 25.8 0.0 0.00032 20.4 0.0 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KII69138.1 - 5.9e-05 23.3 0.4 0.0022 18.3 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KII69138.1 - 0.0003 21.1 0.1 0.092 13.4 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 KII69138.1 - 0.0043 17.4 4.2 0.74 10.4 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 KII69138.1 - 0.0061 16.6 0.2 0.014 15.5 0.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.1 KII69138.1 - 0.013 15.5 0.0 0.049 13.7 0.0 2.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KII69138.1 - 0.23 11.3 2.1 1.6 8.6 0.5 2.7 2 1 2 4 4 4 0 Tetratricopeptide repeat CABIT PF12736.2 KII69139.1 - 0.1 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Cell-cycle sustaining, positive selection, DDE_Tnp_IS1595 PF12762.2 KII69140.1 - 9.4e-09 35.2 0.0 1.8e-08 34.3 0.0 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain ESCRT-II PF05871.7 KII69141.1 - 1.8e-13 50.6 2.3 4.2e-09 36.4 0.1 2.8 2 1 1 3 3 3 2 ESCRT-II complex subunit Nrap PF03813.9 KII69142.1 - 1.8e-74 250.9 13.9 1.1e-36 125.8 0.4 3.6 2 2 1 3 3 3 3 Nrap protein Sybindin PF04099.7 KII69143.1 - 0.00015 21.4 0.0 0.00018 21.2 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family S-AdoMet_synt_M PF02772.11 KII69145.1 - 8.7e-43 145.0 0.0 1.1e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain Pex14_N PF04695.8 KII69146.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pex14_N PF04695.8 KII69147.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Yippee-Mis18 PF03226.9 KII69148.1 - 1.7e-19 69.6 1.8 3.7e-19 68.5 1.3 1.6 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DM PF00751.13 KII69148.1 - 0.00029 20.2 2.7 0.00086 18.7 0.2 2.2 2 0 0 2 2 2 1 DM DNA binding domain PMR5N PF14416.1 KII69148.1 - 0.15 12.0 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 PMR5 N terminal Domain C1_2 PF03107.11 KII69148.1 - 0.76 9.9 4.7 0.26 11.4 0.6 2.1 2 0 0 2 2 2 0 C1 domain RVT_1 PF00078.22 KII69149.1 - 2.8e-06 26.8 0.0 5.1e-06 26.0 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Myotub-related PF06602.9 KII69151.1 - 8.3e-31 107.0 1.1 9.9e-31 106.7 0.8 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DUF4003 PF13170.1 KII69154.1 - 0.073 12.3 0.4 0.085 12.1 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4003) Kelch_6 PF13964.1 KII69157.1 - 1.9e-17 62.6 15.4 0.0001 22.2 0.2 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII69157.1 - 7.4e-16 57.6 18.4 0.00082 19.1 0.1 6.7 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KII69157.1 - 1.8e-13 50.2 7.5 0.012 15.7 0.1 5.9 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII69157.1 - 1e-08 34.5 21.7 0.022 14.3 0.0 6.4 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KII69157.1 - 0.00037 20.1 8.2 2.9 7.7 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.1 KII69157.1 - 0.0011 18.8 16.4 0.94 9.5 0.3 5.8 6 0 0 6 6 6 3 Kelch motif FBA_3 PF08268.7 KII69157.1 - 0.018 14.7 0.2 0.075 12.7 0.0 2.1 2 1 1 3 3 3 0 F-box associated domain Kelch_6 PF13964.1 KII69158.1 - 8.9e-22 76.2 22.4 6.1e-07 29.3 0.0 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII69158.1 - 1.7e-18 66.1 16.3 0.00021 20.9 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KII69158.1 - 1.4e-17 63.2 12.7 0.00059 19.9 0.0 7.2 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII69158.1 - 1.4e-14 53.3 31.1 3.9e-05 23.0 0.8 7.0 7 1 0 7 7 7 5 Kelch motif Kelch_5 PF13854.1 KII69158.1 - 7.4e-07 28.9 13.9 0.0044 16.9 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 KII69158.1 - 0.00038 20.1 19.5 0.52 10.1 0.1 6.5 6 2 0 6 6 6 3 Kelch motif Kelch_3 PF13415.1 KII69159.1 - 1.5e-05 25.0 0.0 3.2e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII69159.1 - 3.3e-05 23.8 0.1 0.002 18.2 0.0 2.4 2 1 1 3 3 3 1 Kelch motif Kelch_4 PF13418.1 KII69159.1 - 0.00038 20.1 0.1 0.00093 18.9 0.0 1.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII69159.1 - 0.0043 16.7 0.3 4 7.3 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Homeobox PF00046.24 KII69160.1 - 3.6e-17 61.7 1.3 5.4e-17 61.1 0.9 1.3 1 0 0 1 1 1 1 Homeobox domain GH-E PF14410.1 KII69160.1 - 0.017 15.2 0.1 0.034 14.2 0.0 1.4 1 0 0 1 1 1 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues Homez PF11569.3 KII69160.1 - 0.44 9.6 2.5 0.52 9.4 0.7 1.9 1 1 1 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Ada3 PF10198.4 KII69160.1 - 0.56 9.9 4.5 3.6 7.3 0.5 2.1 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 rve PF00665.21 KII69162.1 - 1.3e-10 41.4 0.0 2.2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Serpin PF00079.15 KII69163.1 - 1.6e-39 136.1 2.5 1.9e-39 135.8 1.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII69164.1 - 1.3e-48 166.0 3.3 1.4e-48 165.8 2.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) BNR PF02012.15 KII69166.1 - 0.0017 17.8 2.6 0.85 9.6 0.1 3.2 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR_2 PF13088.1 KII69166.1 - 0.014 14.6 0.3 2 7.6 0.3 2.1 1 1 1 2 2 2 0 BNR repeat-like domain Methyltransf_11 PF08241.7 KII69167.1 - 1.9e-10 41.0 0.0 4.4e-10 39.9 0.0 1.7 2 1 0 2 2 2 1 Methyltransferase domain WBS_methylT PF12589.3 KII69167.1 - 2.2e-06 28.0 0.1 3.2e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_23 PF13489.1 KII69167.1 - 8.6e-06 25.5 0.0 1.3e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII69167.1 - 9.1e-05 22.0 0.1 0.00017 21.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KII69167.1 - 0.00015 22.0 0.1 0.00029 21.1 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KII69167.1 - 0.00027 21.3 0.1 0.00095 19.6 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KII69167.1 - 0.0009 19.7 0.1 0.002 18.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.8 KII69167.1 - 0.0013 18.7 0.0 0.0052 16.8 0.0 1.9 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase MetW PF07021.7 KII69167.1 - 0.0052 16.1 0.0 0.0096 15.3 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.8 KII69167.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PDCD2_C PF04194.8 KII69168.1 - 4.3e-18 65.4 11.2 2e-16 60.0 0.2 3.4 2 2 1 3 3 3 3 Programmed cell death protein 2, C-terminal putative domain Abhydrolase_6 PF12697.2 KII69169.1 - 3.6e-20 72.8 0.0 4.1e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KII69169.1 - 2.1e-13 50.2 0.0 2.5e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII69169.1 - 1.2e-09 38.0 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.8 KII69169.1 - 6.9e-08 32.3 0.0 9.6e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.6 KII69169.1 - 3.9e-06 26.1 0.0 0.00095 18.3 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.20 KII69169.1 - 0.003 17.1 0.0 0.0038 16.8 0.0 1.3 1 1 0 1 1 1 1 Lipase (class 3) PAF-AH_p_II PF03403.8 KII69169.1 - 0.0031 15.8 0.1 1.4 7.1 0.0 2.1 1 1 1 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase PF07224.6 KII69169.1 - 0.0046 15.8 0.1 0.012 14.4 0.0 1.8 1 1 0 1 1 1 1 Chlorophyllase DUF676 PF05057.9 KII69169.1 - 0.0053 16.0 0.1 0.012 14.8 0.1 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.10 KII69169.1 - 0.018 14.0 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_3 PF07859.8 KII69169.1 - 0.034 13.7 0.0 0.041 13.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_2 PF01674.13 KII69169.1 - 0.078 12.2 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) Ets PF00178.17 KII69169.1 - 0.079 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Ets-domain Thioesterase PF00975.15 KII69169.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Chlorophyllase2 PF12740.2 KII69169.1 - 0.12 11.2 0.0 0.23 10.3 0.0 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme Nop PF01798.13 KII69170.1 - 4.1e-56 188.4 0.3 1.2e-55 186.9 0.0 1.9 2 0 0 2 2 2 1 Putative snoRNA binding domain NOSIC PF08060.8 KII69170.1 - 3.9e-24 84.1 0.3 1e-23 82.8 0.2 1.8 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 KII69170.1 - 1.3e-18 66.8 0.1 1.3e-18 66.8 0.1 2.2 2 0 0 2 2 2 1 NOP5NT (NUC127) domain FATC PF02260.15 KII69170.1 - 0.16 11.4 0.0 0.4 10.1 0.0 1.6 1 0 0 1 1 1 0 FATC domain Bromo_TP PF07524.8 KII69171.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated NTP_transferase PF00483.18 KII69172.1 - 5.5e-09 35.6 0.0 2.9e-08 33.3 0.0 1.9 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 KII69172.1 - 0.00074 19.6 0.0 0.0019 18.2 0.0 1.6 2 0 0 2 2 2 1 MobA-like NTP transferase domain Hexapep PF00132.19 KII69172.1 - 0.0049 16.3 4.1 0.074 12.5 0.6 2.5 1 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) DUF1894 PF08979.6 KII69173.1 - 0.018 15.0 0.1 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1894) PurA PF04845.8 KII69174.1 - 0.00055 19.1 0.2 0.042 12.9 0.0 2.3 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein AAA_12 PF13087.1 KII69176.1 - 5.4e-42 143.4 0.0 6.1e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 KII69176.1 - 0.013 15.6 0.0 0.025 14.7 0.0 1.4 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.1 KII69177.1 - 3.1e-46 157.8 6.6 3.1e-46 157.8 4.6 2.0 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KII69177.1 - 4.4e-13 48.7 0.0 8e-13 47.9 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KII69177.1 - 6.5e-13 48.7 0.2 5.9e-09 35.7 0.1 2.2 2 0 0 2 2 2 2 AAA domain ResIII PF04851.10 KII69177.1 - 1.2e-06 28.4 0.5 1.2e-06 28.4 0.3 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.16 KII69177.1 - 8.3e-06 25.3 8.1 0.00013 21.3 1.2 2.9 3 0 0 3 3 3 2 UvrD/REP helicase N-terminal domain DUF2075 PF09848.4 KII69177.1 - 6.8e-05 21.9 0.6 0.00014 20.9 0.1 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.9 KII69177.1 - 0.00022 20.8 0.2 0.00065 19.3 0.0 1.8 2 0 0 2 2 2 1 Helicase DEAD PF00270.24 KII69177.1 - 0.00028 20.4 1.0 0.00057 19.4 0.7 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SRP54 PF00448.17 KII69177.1 - 0.0028 17.1 0.1 0.0057 16.1 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SMC_N PF02463.14 KII69177.1 - 0.0049 16.1 2.7 0.19 10.9 0.1 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.24 KII69177.1 - 0.0067 16.6 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PIF1 PF05970.9 KII69177.1 - 0.0073 15.3 0.3 0.29 10.0 0.0 2.4 2 0 0 2 2 2 1 PIF1-like helicase AAA_23 PF13476.1 KII69177.1 - 0.0097 16.2 2.0 0.0097 16.2 1.4 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KII69177.1 - 0.01 15.8 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain T2SE PF00437.15 KII69177.1 - 0.019 13.9 0.1 0.036 12.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.11 KII69177.1 - 0.048 12.8 0.1 0.11 11.7 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.1 KII69177.1 - 0.062 13.4 0.1 0.34 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 KII69177.1 - 0.083 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sec2p PF06428.6 KII69177.1 - 3.1 7.6 6.6 0.37 10.6 0.3 2.6 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p RP-C_C PF11800.3 KII69177.1 - 3.7 7.1 6.3 0.58 9.8 0.8 2.0 1 1 1 2 2 2 0 Replication protein C C-terminal region DUF3398 PF11878.3 KII69179.1 - 0.079 12.8 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) AAA_12 PF13087.1 KII69180.1 - 4e-26 91.6 0.0 4.9e-26 91.3 0.0 1.0 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KII69181.1 - 3.1e-48 164.4 0.2 5.8e-48 163.5 0.2 1.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII69181.1 - 5.7e-14 51.6 0.0 9.4e-14 50.9 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KII69181.1 - 1e-13 51.3 0.0 2.4e-09 37.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.1 KII69181.1 - 1.1e-10 41.3 0.6 4.7e-09 35.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 KII69181.1 - 1.3e-08 34.9 0.3 8.2e-08 32.2 0.1 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.16 KII69181.1 - 6.7e-08 32.1 0.0 3.3e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain DUF2075 PF09848.4 KII69181.1 - 2.9e-05 23.2 0.0 8.5e-05 21.6 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.9 KII69181.1 - 0.00016 21.3 0.0 0.00041 20.0 0.0 1.7 2 0 0 2 2 2 1 Helicase AAA_23 PF13476.1 KII69181.1 - 0.00043 20.6 0.4 0.0007 19.9 0.3 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 KII69181.1 - 0.00054 19.2 0.2 0.00088 18.5 0.1 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain DEAD PF00270.24 KII69181.1 - 0.003 17.0 0.1 0.0054 16.2 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase PIF1 PF05970.9 KII69181.1 - 0.003 16.5 0.0 0.16 10.8 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase SRP54 PF00448.17 KII69181.1 - 0.0036 16.7 0.0 0.006 16.0 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA PF00004.24 KII69181.1 - 0.0053 16.9 0.0 0.0098 16.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 KII69181.1 - 0.015 14.2 0.0 0.024 13.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 KII69181.1 - 0.017 15.1 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.1 KII69181.1 - 0.049 13.1 0.0 0.092 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain KaiC PF06745.8 KII69181.1 - 0.059 12.4 0.2 0.18 10.8 0.1 1.7 1 1 1 2 2 2 0 KaiC PhoH PF02562.11 KII69181.1 - 0.063 12.4 0.0 0.14 11.3 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.1 KII69181.1 - 0.1 12.7 0.0 0.27 11.4 0.0 1.7 2 0 0 2 2 1 0 AAA domain YbgS PF13985.1 KII69181.1 - 0.37 10.7 2.5 0.74 9.7 1.8 1.4 1 0 0 1 1 1 0 YbgS-like protein Gcd10p PF04189.8 KII69182.1 - 0.032 13.3 1.4 0.043 12.9 0.9 1.2 1 0 0 1 1 1 0 Gcd10p family AAA_12 PF13087.1 KII69183.1 - 1.8e-47 161.3 0.3 4.2e-47 160.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.1 KII69183.1 - 0.00069 19.7 0.0 0.0017 18.4 0.0 1.7 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain DUF1687 PF07955.6 KII69183.1 - 0.0007 19.5 0.2 0.0017 18.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) Viral_helicase1 PF01443.13 KII69183.1 - 0.0056 16.2 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase UvrD_C PF13361.1 KII69183.1 - 0.019 14.4 0.2 0.57 9.5 0.0 2.7 3 0 0 3 3 3 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.1 KII69184.1 - 6.5e-20 71.7 0.3 6.5e-20 71.7 0.2 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KII69184.1 - 3.2e-14 52.4 0.0 6.5e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KII69184.1 - 9.3e-10 38.4 0.0 1.8e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.4 KII69184.1 - 3.2e-06 26.3 2.7 3.8e-06 26.1 0.1 2.1 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.1 KII69184.1 - 5.3e-06 26.8 5.5 0.0081 16.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain ResIII PF04851.10 KII69184.1 - 8.2e-06 25.7 0.1 8.2e-06 25.7 0.1 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 KII69184.1 - 2.4e-05 24.0 0.1 5.6e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 Helicase DEAD PF00270.24 KII69184.1 - 0.00028 20.4 0.3 0.00028 20.4 0.2 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.16 KII69184.1 - 0.0005 19.4 2.6 0.001 18.4 0.1 2.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain PhoH PF02562.11 KII69184.1 - 0.00053 19.2 0.1 0.0013 17.9 0.0 1.7 2 0 0 2 2 2 1 PhoH-like protein AAA PF00004.24 KII69184.1 - 0.00093 19.4 0.1 0.0023 18.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 KII69184.1 - 0.00096 18.3 0.0 0.0017 17.5 0.0 1.3 1 0 0 1 1 1 1 KaiC IstB_IS21 PF01695.12 KII69184.1 - 0.0011 18.4 0.2 0.018 14.4 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.1 KII69184.1 - 0.0012 18.8 0.0 0.0028 17.6 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain T2SE PF00437.15 KII69184.1 - 0.0016 17.3 0.1 0.031 13.1 0.0 2.1 1 1 1 2 2 2 1 Type II/IV secretion system protein SRP54 PF00448.17 KII69184.1 - 0.0023 17.4 0.1 0.004 16.6 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_22 PF13401.1 KII69184.1 - 0.0026 17.9 0.1 0.038 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KII69184.1 - 0.0038 16.6 0.0 0.0069 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain PIF1 PF05970.9 KII69184.1 - 0.009 14.9 0.5 0.038 12.9 0.0 2.1 2 0 0 2 2 2 1 PIF1-like helicase ATP-synt_ab PF00006.20 KII69184.1 - 0.011 15.2 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_26 PF13500.1 KII69184.1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KII69184.1 - 0.021 14.4 0.0 0.043 13.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Bac_DnaA PF00308.13 KII69184.1 - 0.022 14.3 2.0 0.088 12.4 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein SMC_N PF02463.14 KII69184.1 - 0.026 13.7 0.5 0.086 12.0 0.0 1.9 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain RNA_helicase PF00910.17 KII69184.1 - 0.026 14.6 0.0 0.094 12.9 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.16 KII69184.1 - 0.031 13.4 0.0 0.058 12.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF258 PF03193.11 KII69184.1 - 0.069 12.3 0.0 0.21 10.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 KII69184.1 - 0.069 12.8 0.0 0.29 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 KII69184.1 - 0.076 12.7 3.0 0.095 12.3 0.1 2.1 2 0 0 2 2 2 0 Archaeal ATPase AAA_29 PF13555.1 KII69184.1 - 0.12 11.8 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_12 PF13087.1 KII69185.1 - 3.1e-47 160.5 0.1 4.7e-47 159.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KII69185.1 - 1.1e-23 84.0 0.0 1.6e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KII69185.1 - 0.0015 18.1 0.0 0.35 10.3 0.0 2.2 1 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 KII69185.1 - 0.0035 17.4 0.0 0.02 15.0 0.0 2.2 3 0 0 3 3 3 1 UvrD-like helicase C-terminal domain tRNA-synt_2e PF02091.10 KII69186.1 - 0.017 14.2 1.4 0.026 13.6 0.6 1.5 1 1 0 1 1 1 0 Glycyl-tRNA synthetase alpha subunit NDK PF00334.14 KII69187.1 - 0.061 13.1 3.7 2.9 7.6 0.0 3.8 1 1 3 4 4 4 0 Nucleoside diphosphate kinase CCP_MauG PF03150.9 KII69187.1 - 0.27 11.5 8.2 6.7e+02 0.4 5.7 3.6 1 1 0 1 1 1 0 Di-haem cytochrome c peroxidase RbsD_FucU PF05025.8 KII69187.1 - 3.4 7.9 8.5 34 4.7 0.1 3.7 2 1 2 4 4 4 0 RbsD / FucU transport protein family DUF1204 PF06721.6 KII69187.1 - 3.6 6.7 11.2 11 5.1 0.1 3.8 1 1 3 5 5 5 0 Protein of unknown function (DUF1204) DUF932 PF06067.6 KII69187.1 - 4.8 6.4 6.2 14 4.8 0.6 3.1 1 1 3 4 4 4 0 Domain of unknown function (DUF932) Flu_M2 PF00599.12 KII69187.1 - 5.6 6.8 15.3 28 4.5 0.1 4.9 5 1 0 5 5 5 0 Influenza Matrix protein (M2) WD40 PF00400.27 KII69188.1 - 2.9e-08 33.2 6.4 0.0014 18.4 0.2 4.7 6 0 0 6 6 6 3 WD domain, G-beta repeat Anth_Ig PF05587.8 KII69188.1 - 0.012 15.4 0.1 0.056 13.2 0.0 2.1 2 0 0 2 2 2 0 Anthrax receptor extracellular domain FixQ PF05545.6 KII69189.1 - 0.8 9.3 5.7 1.7 8.3 4.0 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Hydrolase_6 PF13344.1 KII69192.1 - 1.5e-22 79.3 0.0 2.3e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Galactosyl_T PF01762.16 KII69193.1 - 8.3e-27 94.0 0.4 1.5e-26 93.2 0.3 1.4 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.11 KII69193.1 - 0.0042 16.3 0.0 0.0086 15.3 0.0 1.6 1 1 0 1 1 1 1 Fringe-like WD40 PF00400.27 KII69194.1 - 8.6e-16 57.1 5.4 1.4e-05 24.7 0.0 4.2 5 0 0 5 5 5 3 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KII69194.1 - 0.071 11.8 0.2 0.18 10.4 0.1 1.7 1 1 1 2 2 2 0 Nup133 N terminal like MFS_1 PF07690.11 KII69195.1 - 7.4e-08 31.4 23.7 7.4e-08 31.4 16.5 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF423 PF04241.10 KII69195.1 - 0.064 13.1 0.0 0.064 13.1 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF423) CUE PF02845.11 KII69196.1 - 1.2e-06 27.8 0.0 1.7e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 CUE domain M3 PF09213.5 KII69197.1 - 0.021 13.2 0.0 0.027 12.9 0.0 1.1 1 0 0 1 1 1 0 M3 DDE_3 PF13358.1 KII69198.1 - 1.8e-11 43.9 0.0 3.3e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DnaA_N PF11638.3 KII69198.1 - 0.048 13.2 0.0 0.13 11.8 0.0 1.6 2 0 0 2 2 2 0 DnaA N-terminal domain DUF1682 PF07946.9 KII69198.1 - 0.14 11.0 0.1 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Sarcoglycan_1 PF04790.8 KII69201.1 - 0.011 14.9 0.2 0.02 14.1 0.1 1.3 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein Hexokinase_2 PF03727.11 KII69201.1 - 0.032 13.4 0.3 0.056 12.6 0.2 1.4 1 0 0 1 1 1 0 Hexokinase Tme5_EGF_like PF09064.5 KII69207.1 - 1.2 8.8 5.7 0.33 10.6 1.8 1.7 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like KAT11 PF08214.6 KII69208.1 - 8.6e-50 169.7 1.8 8.6e-50 169.7 1.3 2.0 2 0 0 2 2 2 1 Histone acetylation protein Bromodomain PF00439.20 KII69208.1 - 6.3e-13 48.4 0.0 1.8e-12 47.0 0.0 1.8 1 0 0 1 1 1 1 Bromodomain zf-TAZ PF02135.11 KII69208.1 - 1.1e-12 47.7 44.5 5e-09 36.0 12.5 4.4 5 0 0 5 5 5 2 TAZ zinc finger DUF902 PF06001.8 KII69208.1 - 5.6e-12 45.6 7.2 5.6e-12 45.6 5.0 2.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) ATG27 PF09451.5 KII69209.1 - 7.9 5.6 8.3 0.23 10.6 1.3 1.7 2 0 0 2 2 2 0 Autophagy-related protein 27 Peptidase_C9 PF01707.11 KII69211.1 - 0.0071 15.9 0.2 0.017 14.7 0.1 1.6 1 1 0 1 1 1 1 Peptidase family C9 DDE_3 PF13358.1 KII69212.1 - 1.3e-19 70.4 0.0 1.8e-19 69.9 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII69212.1 - 0.00025 20.2 0.1 0.00028 20.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Colicin_Pyocin PF01320.13 KII69212.1 - 0.0013 18.5 0.1 0.0023 17.7 0.0 1.4 1 1 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein rve PF00665.21 KII69212.1 - 0.0061 16.6 0.0 0.0089 16.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DUF2024 PF09630.5 KII69212.1 - 0.0077 15.9 0.1 0.013 15.1 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF2024) DDE_Tnp_IS1595 PF12762.2 KII69215.1 - 0.0038 17.0 2.9 0.73 9.6 0.4 2.2 1 1 1 2 2 2 2 ISXO2-like transposase domain Sec8_exocyst PF04048.9 KII69216.1 - 6.6e-05 22.5 1.3 6.6e-05 22.5 0.9 2.7 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain CENP-H PF05837.7 KII69216.1 - 0.055 13.6 4.3 0.13 12.4 1.3 2.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF3987 PF13148.1 KII69228.1 - 1.6e-84 283.6 0.3 1.9e-84 283.4 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) SicP-binding PF09119.5 KII69229.1 - 0.025 14.2 0.0 0.066 12.9 0.0 1.6 1 0 0 1 1 1 0 SicP binding Kelch_6 PF13964.1 KII69231.1 - 2.1e-08 33.9 4.6 0.00025 21.0 0.3 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII69231.1 - 4.7e-06 26.6 0.4 0.00038 20.5 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KII69231.1 - 7.2e-06 25.6 1.8 5.6e-05 22.8 0.2 2.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.20 KII69231.1 - 9.8e-05 21.8 8.8 0.00049 19.5 1.7 3.2 2 1 0 2 2 2 1 Kelch motif Kelch_5 PF13854.1 KII69231.1 - 0.0016 18.3 3.1 0.0023 17.8 0.5 2.3 2 0 0 2 2 2 1 Kelch motif MULE PF10551.4 KII69232.1 - 0.0012 18.9 0.1 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.13 KII69232.1 - 0.098 11.1 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Transposase, Mutator family RVP PF00077.15 KII69233.1 - 1.2e-05 25.1 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII69233.1 - 0.08 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-AD PF07776.10 KII69234.1 - 0.037 14.0 0.2 0.096 12.6 0.1 1.6 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) Zn_ribbon_2 PF12674.2 KII69234.1 - 0.05 13.9 0.1 0.086 13.1 0.0 1.5 1 1 0 1 1 1 0 Putative zinc ribbon domain Kelch_1 PF01344.20 KII69235.1 - 1.1e-11 44.0 3.6 7.9e-07 28.5 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 KII69235.1 - 1.2e-10 41.0 2.9 5.3e-05 23.2 0.1 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII69235.1 - 1.7e-07 31.2 0.4 0.0027 17.8 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.1 KII69235.1 - 3.3e-07 29.9 3.0 0.0041 16.8 0.1 3.7 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KII69235.1 - 5.6e-05 22.9 0.8 0.083 12.8 0.1 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII69235.1 - 0.00076 19.1 2.5 0.083 12.6 0.1 3.6 3 1 0 3 3 3 1 Kelch motif RVP PF00077.15 KII69236.1 - 1.1e-05 25.2 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII69236.1 - 0.073 12.9 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF1281 PF06924.6 KII69237.1 - 0.14 11.5 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) TrmB PF01978.14 KII69238.1 - 0.0017 18.0 0.1 0.003 17.2 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.1 KII69238.1 - 0.0034 16.9 0.1 0.0075 15.8 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII69238.1 - 0.01 15.8 0.3 0.019 14.9 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_27 PF13463.1 KII69238.1 - 0.038 14.3 0.1 0.083 13.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain DDE_Tnp_IS1595 PF12762.2 KII69242.1 - 3.7e-18 65.7 0.0 5e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain rve PF00665.21 KII69242.1 - 0.051 13.6 0.0 0.089 12.9 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_1_5 PF13737.1 KII69243.1 - 0.074 13.2 0.1 0.1 12.7 0.1 1.2 1 0 0 1 1 1 0 Transposase DDE domain DDE_Tnp_IS1595 PF12762.2 KII69244.1 - 1.2e-16 60.8 0.0 1.5e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain SAM_1 PF00536.25 KII69246.1 - 1.2e-08 35.0 0.4 0.00023 21.2 0.0 2.1 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KII69246.1 - 2.8e-07 30.2 1.0 0.0015 18.3 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) FragX_IP PF05994.6 KII69249.1 - 5.6e-100 335.3 38.0 8.5e-100 334.7 26.4 1.2 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DDE_Tnp_IS1595 PF12762.2 KII69251.1 - 1.7e-17 63.6 0.0 2.3e-17 63.2 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain ADK PF00406.17 KII69255.1 - 5.8e-41 139.8 0.0 7e-41 139.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 KII69255.1 - 9.6e-10 38.8 0.1 1.5e-09 38.2 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KII69255.1 - 2.6e-07 30.6 0.0 6.5e-07 29.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII69255.1 - 2.6e-07 31.4 0.0 5.8e-07 30.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KII69255.1 - 5.3e-06 25.6 0.0 6.3e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.12 KII69255.1 - 9.2e-06 25.1 0.1 0.0043 16.4 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase HEAT_2 PF13646.1 KII69256.1 - 2.3e-25 88.6 0.0 4.3e-11 42.9 0.0 3.6 2 2 2 4 4 4 3 HEAT repeats HEAT_PBS PF03130.11 KII69256.1 - 1e-21 75.1 0.1 0.00064 19.9 0.0 5.6 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT_EZ PF13513.1 KII69256.1 - 1.1e-05 25.7 0.2 0.56 10.7 0.0 4.0 3 1 1 4 4 4 2 HEAT-like repeat HEAT PF02985.17 KII69256.1 - 1.3e-05 24.8 0.1 0.55 10.4 0.0 5.0 5 1 0 5 5 5 2 HEAT repeat Arm PF00514.18 KII69256.1 - 0.029 14.1 0.0 0.54 10.1 0.0 2.6 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat EMG1 PF03587.9 KII69257.1 - 8.7e-43 145.9 0.2 1.3e-42 145.4 0.2 1.2 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase DcpS PF05652.7 KII69257.1 - 0.062 13.6 0.1 0.077 13.3 0.0 1.2 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme (DcpS) N-terminal PapC_N PF13954.1 KII69258.1 - 1.5e-35 121.9 0.0 1.9e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 PapC N-terminal domain Fimbrial PF00419.15 KII69259.1 - 9.4e-10 38.8 0.0 1.2e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 Fimbrial protein Fimbrial PF00419.15 KII69260.1 - 2.8e-17 63.2 1.1 3.8e-17 62.8 0.8 1.1 1 0 0 1 1 1 1 Fimbrial protein DDE_3 PF13358.1 KII69263.1 - 3.2e-10 39.9 0.0 4.9e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease TraA PF05513.6 KII69264.1 - 2.9e-12 46.7 0.1 3.7e-12 46.4 0.1 1.2 1 0 0 1 1 1 1 TraA Response_reg PF00072.19 KII69265.1 - 5.1e-09 36.1 0.1 8.4e-09 35.4 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain OKR_DC_1_N PF03709.10 KII69265.1 - 0.0043 17.1 0.0 0.0087 16.1 0.0 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain DUF1947 PF09183.5 KII69265.1 - 0.0085 15.8 1.3 5.2 6.9 0.2 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF1947) ABC2_membrane_3 PF12698.2 KII69265.1 - 0.048 12.7 0.1 0.057 12.4 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein BetR PF08667.5 KII69265.1 - 0.058 13.3 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 BetR domain HATPase_c PF02518.21 KII69266.1 - 1.6e-24 85.7 1.0 1.3e-23 82.8 0.1 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Acetyltransf_1 PF00583.19 KII69266.1 - 7.5e-13 48.3 0.1 1.9e-12 47.0 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KII69266.1 - 2.9e-10 40.1 0.2 1.2e-09 38.2 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KII69266.1 - 2.1e-09 37.5 0.0 4.3e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Oxidored_molyb PF00174.14 KII69266.1 - 2.5e-06 27.0 0.0 4.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain HATPase_c_5 PF14501.1 KII69266.1 - 7.4e-05 22.3 0.4 0.00025 20.6 0.3 2.0 1 0 0 1 1 1 1 GHKL domain FR47 PF08445.5 KII69266.1 - 0.00013 21.6 0.0 0.0011 18.6 0.0 2.3 2 0 0 2 2 2 1 FR47-like protein HATPase_c_2 PF13581.1 KII69266.1 - 0.0018 18.0 0.0 0.0038 16.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Acetyltransf_9 PF13527.1 KII69266.1 - 0.0029 17.4 0.0 0.0062 16.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KII69266.1 - 0.0081 16.3 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Tra_M PF05261.6 KII69267.1 - 6.1e-09 36.0 0.4 6.7e-09 35.8 0.3 1.1 1 0 0 1 1 1 1 TraM protein, DNA-binding WSN PF02206.13 KII69267.1 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function vATP-synt_AC39 PF01992.11 KII69268.1 - 3.8e-79 266.2 0.3 4.2e-79 266.1 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Cation_efflux PF01545.16 KII69269.1 - 7.1e-26 90.9 10.5 1.7e-25 89.6 7.2 1.6 1 1 0 1 1 1 1 Cation efflux family zf-BED PF02892.10 KII69270.1 - 0.0011 18.6 0.7 0.0031 17.2 0.5 1.8 1 0 0 1 1 1 1 BED zinc finger DUF3834 PF12916.2 KII69275.1 - 0.029 13.3 0.1 0.038 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) zf-CCHC PF00098.18 KII69277.1 - 2.6e-05 23.9 0.7 5e-05 23.0 0.5 1.5 1 0 0 1 1 1 1 Zinc knuckle CRM1_C PF08767.6 KII69279.1 - 0.049 12.5 1.5 0.051 12.4 1.0 1.0 1 0 0 1 1 1 0 CRM1 C terminal DDE_Tnp_IS1595 PF12762.2 KII69280.1 - 2.6e-05 24.1 0.1 5.4e-05 23.0 0.0 1.6 2 0 0 2 2 2 1 ISXO2-like transposase domain SNAP PF14938.1 KII69283.1 - 1.7e-06 27.4 0.4 2.1e-06 27.0 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP ATG13 PF10033.4 KII69284.1 - 0.012 15.0 0.6 0.014 14.7 0.2 1.3 1 1 0 1 1 1 0 Autophagy-related protein 13 CreA PF05981.7 KII69284.1 - 0.39 10.2 1.9 0.38 10.2 0.6 1.5 2 0 0 2 2 2 0 CreA protein ATE_C PF04377.10 KII69285.1 - 0.093 12.7 0.3 0.11 12.5 0.2 1.0 1 0 0 1 1 1 0 Arginine-tRNA-protein transferase, C terminus Vps54 PF07928.7 KII69286.1 - 0.027 14.6 0.1 0.046 13.8 0.1 1.3 1 0 0 1 1 1 0 Vps54-like protein Gp-FAR-1 PF05823.7 KII69286.1 - 0.033 14.1 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) HTH_Tnp_IS630 PF01710.11 KII69287.1 - 2.5e-06 27.1 0.2 3.1e-06 26.8 0.2 1.2 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII69287.1 - 1.3e-05 25.8 0.1 3e-05 24.7 0.1 1.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII69287.1 - 3.2e-05 23.8 0.1 0.0002 21.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 KII69287.1 - 0.00011 21.7 0.1 0.001 18.6 0.0 2.4 2 1 1 3 3 3 1 Homeodomain-like domain PAX PF00292.13 KII69287.1 - 0.00034 20.3 0.2 0.0016 18.1 0.1 1.9 1 1 1 2 2 2 1 'Paired box' domain HTH_29 PF13551.1 KII69287.1 - 0.001 19.2 0.2 0.002 18.2 0.0 1.5 2 0 0 2 2 2 1 Winged helix-turn helix HTH_24 PF13412.1 KII69287.1 - 0.0014 17.9 0.6 0.22 10.9 0.0 3.3 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_Tnp_Tc3_2 PF01498.13 KII69287.1 - 0.002 18.1 0.4 0.002 18.1 0.3 1.7 2 0 0 2 2 2 1 Transposase HTH_Crp_2 PF13545.1 KII69287.1 - 0.08 12.7 0.1 2.3 8.0 0.0 2.3 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_33 PF13592.1 KII69287.1 - 0.14 11.7 0.0 0.29 10.7 0.0 1.6 1 1 0 1 1 1 0 Winged helix-turn helix NOG1 PF06858.9 KII69288.1 - 0.0081 16.0 0.0 6.3 6.7 0.0 2.8 2 0 0 2 2 2 2 Nucleolar GTP-binding protein 1 (NOG1) DDE_3 PF13358.1 KII69290.1 - 5.6e-05 22.9 0.0 0.0001 22.0 0.0 1.3 2 0 0 2 2 2 1 DDE superfamily endonuclease WD40 PF00400.27 KII69291.1 - 4.4e-05 23.1 0.2 0.03 14.2 0.1 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat BBS2_Mid PF14783.1 KII69291.1 - 0.0079 15.9 0.8 0.22 11.3 0.1 3.1 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region DDE_Tnp_IS1595 PF12762.2 KII69292.1 - 1.9e-08 34.2 0.6 1.5e-07 31.3 0.4 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain MIR PF02815.14 KII69297.1 - 2.2e-16 59.9 0.2 2.5e-11 43.4 0.1 2.5 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 KII69297.1 - 0.0082 15.1 0.1 0.4 9.6 0.0 2.5 2 1 1 3 3 3 2 Inositol 1,4,5-trisphosphate/ryanodine receptor FtsJ PF01728.14 KII69298.1 - 5.3e-23 81.9 0.0 8.6e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Mic1 PF07035.7 KII69299.1 - 8.2e-06 25.2 1.1 2e-05 23.9 0.8 1.7 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Dimer_Tnp_hAT PF05699.9 KII69300.1 - 3e-07 29.9 0.2 4.6e-07 29.3 0.2 1.3 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region Metallophos PF00149.23 KII69302.1 - 2.8e-44 150.9 0.2 3.5e-44 150.6 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF316 PF03761.10 KII69302.1 - 0.019 14.3 0.1 0.027 13.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF316) RINGv PF12906.2 KII69305.1 - 4.5e-13 49.0 9.8 7.4e-13 48.3 6.8 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 KII69305.1 - 0.39 10.5 7.3 0.66 9.8 5.1 1.4 1 0 0 1 1 1 0 Ring finger domain SH3_1 PF00018.23 KII69306.1 - 6.6e-16 57.4 0.1 1.2e-15 56.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KII69306.1 - 1.4e-15 56.5 0.1 2.6e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KII69306.1 - 1.8e-11 43.3 0.0 4.1e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.18 KII69306.1 - 0.00086 19.4 1.5 0.0017 18.5 0.1 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Paramyxo_ncap PF00973.14 KII69306.1 - 0.53 8.9 4.0 0.83 8.2 2.7 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein FokI_N PF02981.10 KII69306.1 - 1.1 8.8 3.7 3.5 7.2 0.3 2.4 1 1 1 2 2 2 0 Restriction endonuclease FokI, recognition domain ShK PF01549.19 KII69306.1 - 6.6 7.1 8.2 0.98 9.8 0.6 2.9 3 0 0 3 3 3 0 ShK domain-like DUF3482 PF11981.3 KII69306.1 - 8 5.5 6.7 3.7 6.7 2.2 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3482) MFS_1 PF07690.11 KII69308.1 - 0.00031 19.5 0.2 0.0021 16.8 0.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily rve PF00665.21 KII69309.1 - 3.9e-28 97.9 0.0 7.4e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69309.1 - 0.0017 17.8 0.1 0.0039 16.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII69309.1 - 0.0061 15.9 0.3 0.035 13.4 0.0 2.4 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger VRP1 PF03538.9 KII69309.1 - 0.056 12.4 0.1 0.18 10.7 0.0 1.8 2 0 0 2 2 2 0 Salmonella virulence plasmid 28.1kDa A protein GCD14 PF08704.5 KII69310.1 - 2.6e-11 43.4 0.1 3.6e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Gcd10p PF04189.8 KII69310.1 - 0.0081 15.3 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 Gcd10p family GCD14 PF08704.5 KII69311.1 - 1.2e-12 47.8 0.6 1.4e-12 47.6 0.4 1.0 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Terpene_synth PF01397.16 KII69311.1 - 0.12 11.6 0.5 0.16 11.3 0.3 1.2 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain AMP-binding_C PF13193.1 KII69312.1 - 0.0095 16.8 0.0 0.014 16.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.23 KII69313.1 - 0.00011 20.7 0.0 0.00013 20.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PSII_Pbs27 PF13326.1 KII69313.1 - 0.14 12.0 0.0 0.19 11.7 0.0 1.1 1 0 0 1 1 1 0 Photosystem II Pbs27 DnaJ PF00226.26 KII69314.1 - 2.7e-20 71.8 0.2 8.1e-20 70.3 0.2 1.9 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.17 KII69314.1 - 7e-07 28.7 0.4 7e-06 25.5 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII69314.1 - 1.7e-05 24.5 0.1 5.1e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4243 PF14027.1 KII69314.1 - 0.00054 19.5 0.4 0.001 18.6 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4243) RRM_6 PF14259.1 KII69314.1 - 0.0038 17.1 0.0 0.013 15.4 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Cytochrome-c551 PF10643.4 KII69314.1 - 0.043 13.1 1.4 0.056 12.7 0.9 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 Nup35_RRM_2 PF14605.1 KII69314.1 - 0.047 13.4 0.0 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Thioredoxin_8 PF13905.1 KII69314.1 - 0.15 12.1 1.1 3.6 7.7 0.1 2.8 2 1 0 2 2 2 0 Thioredoxin-like Ribosomal_S13 PF00416.17 KII69314.1 - 0.16 12.3 4.0 0.44 11.0 2.7 1.8 1 1 0 1 1 1 0 Ribosomal protein S13/S18 ERCC4 PF02732.10 KII69314.1 - 1.1 9.0 5.4 1.3 8.7 1.7 2.1 1 1 1 2 2 2 0 ERCC4 domain DUF106 PF01956.11 KII69314.1 - 9.7 5.6 10.2 1.1 8.7 2.5 2.2 1 1 1 2 2 2 0 Integral membrane protein DUF106 PTCB-BRCT PF12738.2 KII69315.1 - 7e-33 112.2 2.2 9.3e-13 47.8 0.1 4.7 4 0 0 4 4 4 4 twin BRCT domain BRCT PF00533.21 KII69315.1 - 5.4e-32 109.7 3.0 2e-09 37.4 0.0 5.3 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain DUF1537 PF07005.6 KII69315.1 - 0.21 11.2 0.0 0.35 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF1537 rve PF00665.21 KII69316.1 - 5.2e-25 87.8 0.0 9.1e-25 87.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69316.1 - 0.02 14.3 0.0 0.051 13.0 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Peptidase_C65 PF10275.4 KII69317.1 - 9.7e-06 25.0 0.5 2.5e-05 23.7 0.3 1.7 1 1 0 1 1 1 1 Peptidase C65 Otubain Vps51 PF08700.6 KII69318.1 - 1.3e-12 47.3 0.9 4.1e-12 45.7 0.6 1.9 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.7 KII69318.1 - 0.00022 19.8 1.4 0.00044 18.8 0.8 1.6 1 1 0 1 1 1 1 Dor1-like family COG2 PF06148.6 KII69318.1 - 0.0021 17.9 0.9 0.0088 15.9 0.6 2.1 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.7 KII69318.1 - 0.11 12.3 2.4 0.31 10.8 1.7 1.8 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.7 KII69318.1 - 0.31 10.8 6.4 1.2 8.9 0.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.4 KII69318.1 - 0.5 10.2 2.8 0.47 10.3 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_membrane PF00664.18 KII69319.1 - 0.00057 19.3 1.5 0.00071 19.0 1.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region LRR_6 PF13516.1 KII69319.1 - 0.018 15.0 0.8 0.063 13.3 0.1 2.2 2 0 0 2 2 2 0 Leucine Rich repeat ABC_tran PF00005.22 KII69320.1 - 4.6e-17 62.6 0.0 6.9e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KII69320.1 - 1.3e-07 31.1 0.1 1.4e-07 30.9 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KII69320.1 - 0.011 15.6 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KII69320.1 - 0.039 13.8 0.4 0.38 10.6 0.3 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DEK_C PF08766.6 KII69320.1 - 0.041 13.6 0.1 0.084 12.6 0.1 1.5 1 0 0 1 1 1 0 DEK C terminal domain Autophagy_act_C PF03987.10 KII69322.1 - 7.4e-24 83.7 0.4 1.2e-23 83.0 0.2 1.4 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 KII69322.1 - 5.9e-15 54.0 0.3 1.2e-14 53.0 0.2 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal MNE1 PF13762.1 KII69322.1 - 0.01 15.9 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component CAP PF00188.21 KII69322.1 - 0.03 14.8 0.0 0.033 14.6 0.0 1.2 1 0 0 1 1 1 0 Cysteine-rich secretory protein family EssA PF10661.4 KII69324.1 - 0.058 13.0 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA MUG113 PF13455.1 KII69325.1 - 0.039 14.3 0.0 0.043 14.2 0.0 1.2 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 T5orf172 PF10544.4 KII69325.1 - 0.083 13.2 0.0 0.09 13.1 0.0 1.2 1 0 0 1 1 1 0 T5orf172 domain NUMOD1 PF07453.8 KII69327.1 - 0.18 11.7 0.5 0.18 11.7 0.4 2.2 2 0 0 2 2 2 0 NUMOD1 domain CTV_P33 PF07184.6 KII69327.1 - 0.24 10.2 4.7 0.27 10.0 3.3 1.1 1 0 0 1 1 1 0 Citrus tristeza virus P33 protein DDE_1 PF03184.14 KII69328.1 - 7.6e-16 57.8 0.1 9.3e-16 57.6 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease CtaG_Cox11 PF04442.9 KII69331.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein CtaG/Cox11 DDE_3 PF13358.1 KII69333.1 - 1.2e-07 31.5 0.1 2.1e-07 30.7 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Spy1 PF11357.3 KII69334.1 - 0.11 12.6 0.2 0.12 12.4 0.1 1.2 1 0 0 1 1 1 0 Cell cycle regulatory protein DUF3944 PF13099.1 KII69337.1 - 3.7 7.1 7.2 6.4 6.3 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3944) FLYWCH PF04500.11 KII69339.1 - 2.6e-09 36.8 0.1 5.5e-09 35.7 0.1 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain YdjO PF14169.1 KII69339.1 - 0.0064 15.9 0.1 0.013 14.9 0.1 1.4 1 0 0 1 1 1 1 Cold-inducible protein YdjO AGT PF11440.3 KII69341.1 - 0.05 12.4 0.0 0.081 11.7 0.0 1.2 1 0 0 1 1 1 0 DNA alpha-glucosyltransferase DUF2418 PF10332.4 KII69341.1 - 0.087 13.1 0.2 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) Glyco_hydro_59 PF02057.10 KII69342.1 - 0.084 10.9 1.3 0.11 10.5 0.8 1.3 1 1 0 1 1 1 0 Glycosyl hydrolase family 59 Sec7 PF01369.15 KII69343.1 - 0.0045 16.6 2.4 0.01 15.4 0.2 2.2 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.1 KII69343.1 - 0.0074 16.4 1.5 0.16 12.1 0.2 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain DUF2372 PF10178.4 KII69345.1 - 0.0016 18.5 0.1 0.0021 18.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2372) DnaB PF00772.16 KII69345.1 - 0.005 16.6 0.0 0.0079 16.0 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase N terminal domain AAA_11 PF13086.1 KII69346.1 - 8e-50 169.6 0.8 1.1e-49 169.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 KII69346.1 - 3.8e-49 166.8 0.1 3.9e-48 163.5 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.1 KII69346.1 - 2e-13 50.3 0.0 7.6e-10 38.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KII69346.1 - 6.9e-13 48.1 0.1 1.5e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 KII69346.1 - 1.9e-07 31.0 0.0 5e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 KII69346.1 - 1.8e-06 27.1 1.8 1e-05 24.7 0.1 2.9 5 0 0 5 5 5 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.16 KII69346.1 - 7.4e-05 22.1 2.1 0.00026 20.3 0.0 2.5 2 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain KaiC PF06745.8 KII69346.1 - 0.00046 19.3 0.0 0.00086 18.4 0.0 1.4 1 0 0 1 1 1 1 KaiC DEAD PF00270.24 KII69346.1 - 0.0005 19.6 0.1 0.0014 18.1 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_RecD PF05127.9 KII69346.1 - 0.00081 19.0 0.0 0.0021 17.7 0.0 1.7 1 0 0 1 1 1 1 Helicase PhoH PF02562.11 KII69346.1 - 0.0039 16.4 0.0 0.062 12.5 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein PIF1 PF05970.9 KII69346.1 - 0.0066 15.4 0.0 0.16 10.8 0.0 2.4 2 0 0 2 2 2 1 PIF1-like helicase AAA PF00004.24 KII69346.1 - 0.0098 16.0 0.0 0.027 14.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 KII69346.1 - 0.015 14.6 0.0 0.14 11.5 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.1 KII69346.1 - 0.018 15.3 2.1 0.08 13.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 KII69346.1 - 0.025 13.4 0.0 0.042 12.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 KII69346.1 - 0.036 14.0 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.17 KII69346.1 - 0.041 13.3 0.1 0.08 12.3 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain SMC_N PF02463.14 KII69346.1 - 0.057 12.6 0.0 0.16 11.1 0.0 1.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain TrwB_AAD_bind PF10412.4 KII69346.1 - 0.062 11.9 0.1 0.17 10.4 0.0 1.7 2 1 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.1 KII69346.1 - 0.067 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KII69346.1 - 0.074 12.2 0.8 0.29 10.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 UvrD_C_2 PF13538.1 KII69346.1 - 0.09 12.9 0.0 0.65 10.1 0.0 2.4 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.1 KII69346.1 - 0.14 12.3 0.1 0.61 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 KII69348.1 - 6.8e-15 55.3 0.0 1.2e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KII69348.1 - 1.6e-08 33.7 0.0 2.3e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KII69348.1 - 4e-05 23.3 0.1 0.00013 21.7 0.1 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain zf-UBR PF02207.15 KII69349.1 - 6.4e-15 54.6 20.8 1.6e-14 53.3 14.4 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) F_actin_bind PF08919.5 KII69349.1 - 0.042 13.5 0.8 0.17 11.5 0.1 2.4 2 0 0 2 2 2 0 F-actin binding Dioxygenase_C PF00775.16 KII69351.1 - 0.13 11.5 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Dioxygenase DUF3725 PF12523.3 KII69352.1 - 0.11 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) Peptidase_M2 PF01401.13 KII69353.1 - 0.074 11.2 0.0 0.079 11.1 0.0 1.1 1 0 0 1 1 1 0 Angiotensin-converting enzyme FLYWCH PF04500.11 KII69355.1 - 2.5e-06 27.2 0.8 5.1e-06 26.2 0.5 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain Zn_ribbon_recom PF13408.1 KII69355.1 - 0.083 13.1 2.5 0.17 12.1 1.7 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Lipin_N PF04571.9 KII69357.1 - 0.073 12.7 0.1 0.2 11.3 0.1 1.7 1 1 0 1 1 1 0 lipin, N-terminal conserved region RVP PF00077.15 KII69359.1 - 0.00015 21.5 0.0 0.00026 20.8 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Smg4_UPF3 PF03467.10 KII69359.1 - 0.029 14.3 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 Smg-4/UPF3 family CortBP2 PF09727.4 KII69361.1 - 0.024 14.1 4.6 0.028 13.9 3.2 1.1 1 0 0 1 1 1 0 Cortactin-binding protein-2 COG2 PF06148.6 KII69361.1 - 0.08 12.8 3.3 0.1 12.4 2.3 1.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Sec20 PF03908.8 KII69361.1 - 0.69 9.6 3.2 0.85 9.3 1.7 1.6 1 1 0 1 1 1 0 Sec20 DDE_1 PF03184.14 KII69363.1 - 1.3e-09 37.4 0.0 1.5e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease FH2 PF02181.18 KII69364.1 - 0.0046 15.8 1.5 0.0055 15.6 1.1 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Ham1p_like PF01725.11 KII69364.1 - 0.0048 16.2 2.1 0.0064 15.8 1.5 1.2 1 0 0 1 1 1 1 Ham1 family Baculo_PEP_C PF04513.7 KII69364.1 - 0.005 16.6 5.6 0.083 12.7 3.8 2.1 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus MIS13 PF08202.6 KII69364.1 - 0.012 14.7 3.2 0.015 14.3 2.2 1.3 1 0 0 1 1 1 0 Mis12-Mtw1 protein family DUF2785 PF10978.3 KII69364.1 - 0.014 14.8 1.7 0.02 14.3 1.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2785) Pro_CA PF00484.14 KII69364.1 - 0.018 15.0 0.3 0.022 14.7 0.2 1.1 1 0 0 1 1 1 0 Carbonic anhydrase DUF342 PF03961.8 KII69364.1 - 0.019 13.4 8.7 0.022 13.1 6.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF1308 PF07000.6 KII69364.1 - 0.021 13.5 0.1 0.025 13.2 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) Rootletin PF15035.1 KII69364.1 - 0.027 14.4 5.0 0.035 14.0 3.4 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CENP-Q PF13094.1 KII69364.1 - 0.03 14.3 5.2 0.034 14.1 3.6 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1664 PF07889.7 KII69364.1 - 0.031 14.0 4.7 0.47 10.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) IncA PF04156.9 KII69364.1 - 0.033 13.7 7.1 0.04 13.5 5.0 1.2 1 0 0 1 1 1 0 IncA protein Picorna_P3A PF06363.6 KII69364.1 - 0.036 14.0 0.1 0.046 13.7 0.1 1.3 1 0 0 1 1 1 0 Picornaviridae P3A protein ISG65-75 PF11727.3 KII69364.1 - 0.042 12.8 3.8 0.054 12.5 2.6 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Spc7 PF08317.6 KII69364.1 - 0.047 12.3 10.7 0.06 11.9 7.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1732 PF08340.6 KII69364.1 - 0.05 13.4 1.6 0.14 11.9 0.2 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF1732) TTKRSYEDQ PF10212.4 KII69364.1 - 0.052 12.4 5.1 1.3 7.8 1.1 2.0 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DUF1411 PF07199.6 KII69364.1 - 0.055 12.9 0.8 0.07 12.5 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) FliT PF05400.8 KII69364.1 - 0.066 13.6 4.6 0.18 12.1 2.0 2.1 2 0 0 2 2 2 0 Flagellar protein FliT DUF3294 PF07957.6 KII69364.1 - 0.067 12.7 5.5 0.077 12.5 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) COG5 PF10392.4 KII69364.1 - 0.077 12.9 6.0 1.4 8.9 1.2 2.0 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Peptidase_S64 PF08192.6 KII69364.1 - 0.083 11.2 3.2 0.097 10.9 2.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 TPD52 PF04201.10 KII69364.1 - 0.091 12.4 5.3 4 7.1 0.1 2.1 1 1 1 2 2 2 0 Tumour protein D52 family Allexi_40kDa PF05549.6 KII69364.1 - 0.092 12.0 4.1 0.11 11.7 2.8 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein AAA_32 PF13654.1 KII69364.1 - 0.13 10.9 6.6 0.19 10.3 4.6 1.4 1 1 0 1 1 1 0 AAA domain DUF2408 PF10303.4 KII69364.1 - 0.14 12.2 6.5 0.75 9.9 4.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Apolipoprotein PF01442.13 KII69364.1 - 0.16 11.4 6.4 0.31 10.5 4.5 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain MutS_III PF05192.13 KII69364.1 - 0.17 11.6 1.2 0.2 11.3 0.8 1.1 1 0 0 1 1 1 0 MutS domain III Caudo_TAP PF02413.12 KII69364.1 - 0.17 12.0 2.5 0.22 11.6 1.8 1.2 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein MSA-2c PF12238.3 KII69364.1 - 0.2 11.3 3.4 0.25 10.9 2.4 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c Fib_alpha PF08702.5 KII69364.1 - 0.21 11.7 10.6 0.97 9.5 7.4 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.15 KII69364.1 - 0.22 11.3 11.3 4.7 7.0 7.8 2.6 1 1 0 1 1 1 0 Prefoldin subunit Hydantoinase_B PF02538.9 KII69364.1 - 0.29 9.3 3.0 0.31 9.2 2.1 1.0 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase DUF1104 PF06518.6 KII69364.1 - 0.29 11.2 3.5 0.5 10.5 2.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1104) HSCB_C PF07743.8 KII69364.1 - 0.37 11.2 7.0 0.59 10.6 2.3 2.4 1 1 2 3 3 2 0 HSCB C-terminal oligomerisation domain Tropomyosin_1 PF12718.2 KII69364.1 - 0.41 10.4 7.8 0.68 9.7 5.2 1.5 1 1 0 1 1 1 0 Tropomyosin like DUF1319 PF07028.6 KII69364.1 - 0.46 10.6 8.1 0.94 9.6 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Peptidase_C6 PF00851.13 KII69364.1 - 0.52 8.8 4.2 0.59 8.7 2.9 1.0 1 0 0 1 1 1 0 Helper component proteinase Annexin PF00191.15 KII69364.1 - 0.54 10.1 4.3 0.26 11.2 0.5 2.2 2 1 0 2 2 2 0 Annexin LMBR1 PF04791.11 KII69364.1 - 0.56 8.7 2.7 0.6 8.6 1.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein CCDC-167 PF15188.1 KII69364.1 - 0.6 10.0 6.2 0.98 9.4 3.3 2.1 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Hormone_1 PF00103.15 KII69364.1 - 0.63 9.3 5.7 2 7.7 0.5 2.0 1 1 1 2 2 2 0 Somatotropin hormone family Sds3 PF08598.6 KII69364.1 - 0.64 9.5 8.1 0.23 10.9 3.0 1.8 1 1 0 2 2 2 0 Sds3-like DUF4559 PF15112.1 KII69364.1 - 0.73 8.9 5.8 0.89 8.6 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) FliD_N PF02465.13 KII69364.1 - 0.75 10.2 5.4 0.78 10.1 1.3 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus ACCA PF03255.9 KII69364.1 - 0.84 9.1 5.9 0.99 8.9 3.1 1.8 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ATP-synt_F6 PF05511.6 KII69364.1 - 0.85 9.5 3.7 12 5.8 0.1 2.6 1 1 1 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 RBD-FIP PF09457.5 KII69364.1 - 1.2 8.9 6.3 12 5.7 0.1 3.0 1 1 1 2 2 2 0 FIP domain DUF3450 PF11932.3 KII69364.1 - 2.9 7.0 12.1 1.2 8.3 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Syntaxin_2 PF14523.1 KII69364.1 - 3 7.9 10.5 9.4 6.3 6.1 2.2 1 1 0 1 1 1 0 Syntaxin-like protein Lipoprotein_20 PF13942.1 KII69364.1 - 3.4 7.1 8.6 5 6.6 0.8 2.3 1 1 1 2 2 2 0 YfhG lipoprotein DUF1759 PF03564.10 KII69364.1 - 3.5 7.4 8.5 4.3 7.1 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) Serpin PF00079.15 KII69367.1 - 6.8e-33 114.3 5.6 2.7e-18 66.2 1.7 2.0 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) tRNA_U5-meth_tr PF05958.6 KII69367.1 - 0.0097 14.6 0.2 0.0097 14.6 0.2 1.5 2 0 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Serpin PF00079.15 KII69368.1 - 4.2e-47 161.0 3.0 5.1e-47 160.7 2.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII69369.1 - 3.7e-45 154.6 1.3 4.8e-45 154.2 0.9 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.1 KII69370.1 - 0.00053 19.2 0.2 0.00059 19.0 0.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.23 KII69370.1 - 0.041 13.5 0.4 12 5.6 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF2989 PF11207.3 KII69370.1 - 0.059 12.8 0.5 0.12 11.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2989) TPR_11 PF13414.1 KII69370.1 - 0.1 12.2 1.3 1.4 8.6 0.0 2.8 2 1 1 3 3 3 0 TPR repeat Snapin_Pallidin PF14712.1 KII69371.1 - 0.57 10.5 6.4 0.54 10.6 2.6 2.3 1 1 1 2 2 2 0 Snapin/Pallidin Mem_trans PF03547.13 KII69371.1 - 1.2 7.3 3.8 2.5 6.2 2.6 1.6 1 0 0 1 1 1 0 Membrane transport protein DUF4164 PF13747.1 KII69371.1 - 1.4 9.1 8.6 2.8 8.1 4.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) rve_2 PF13333.1 KII69378.1 - 0.054 13.5 0.1 0.21 11.6 0.0 1.9 1 1 1 2 2 2 0 Integrase core domain FoP_duplication PF13865.1 KII69378.1 - 0.16 12.4 1.5 0.57 10.6 0.0 2.3 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 NusB PF01029.13 KII69380.1 - 0.038 13.9 0.5 0.066 13.1 0.3 1.3 1 0 0 1 1 1 0 NusB family Synthase_beta PF11421.3 KII69380.1 - 6.9 7.4 6.4 3.4 8.4 2.2 2.1 3 0 0 3 3 3 0 ATP synthase F1 beta subunit CDC73 PF05179.9 KII69381.1 - 8.4e-58 195.8 0.0 9.9e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family DDE_3 PF13358.1 KII69384.1 - 0.00032 20.4 0.0 0.00038 20.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease EF_TS PF00889.14 KII69387.1 - 3.4e-22 78.8 0.0 3.8e-18 65.6 0.0 2.2 1 1 1 2 2 2 2 Elongation factor TS UBA PF00627.26 KII69387.1 - 0.034 13.9 0.1 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 UBA/TS-N domain DDE_Tnp_IS1595 PF12762.2 KII69388.1 - 1.4e-22 80.1 0.0 6.9e-22 77.8 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain Kelch_6 PF13964.1 KII69390.1 - 1e-05 25.4 5.8 0.015 15.4 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.1 KII69390.1 - 7.8e-05 22.3 9.6 0.093 12.5 0.3 4.5 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII69390.1 - 0.0021 18.1 3.3 5.3 7.3 0.0 4.4 4 1 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII69390.1 - 0.083 12.6 5.3 2.7 7.9 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.20 KII69390.1 - 0.11 12.0 5.8 1.7 8.2 0.1 3.6 4 1 0 4 4 4 0 Kelch motif Kelch_5 PF13854.1 KII69390.1 - 0.2 11.6 3.2 2.3 8.2 0.0 3.0 3 0 0 3 3 3 0 Kelch motif PAN_3 PF08277.7 KII69392.1 - 0.075 12.6 0.0 6.8 6.3 0.0 2.7 2 0 0 2 2 2 0 PAN-like domain WD40 PF00400.27 KII69393.1 - 1e-07 31.5 4.0 1.3e-05 24.8 0.0 4.8 5 0 0 5 5 5 1 WD domain, G-beta repeat BBS2_N PF14781.1 KII69393.1 - 0.11 12.0 1.5 0.19 11.3 0.1 2.2 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal Utp21 PF04192.7 KII69394.1 - 1.9e-31 108.9 1.3 3e-31 108.3 0.9 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain Rot1 PF10681.4 KII69394.1 - 0.012 14.9 0.1 0.016 14.5 0.0 1.1 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal RFC1 PF08519.7 KII69394.1 - 0.083 12.6 0.1 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain RE_R_Pab1 PF09522.5 KII69395.1 - 0.039 13.8 0.3 0.11 12.3 0.1 1.9 1 1 0 1 1 1 0 R.Pab1 restriction endonuclease Topo-VIb_trans PF09239.6 KII69395.1 - 0.14 11.6 1.8 0.15 11.6 0.3 1.6 2 0 0 2 2 2 0 Topoisomerase VI B subunit, transducer HTH_3 PF01381.17 KII69397.1 - 0.00065 19.4 0.2 0.011 15.6 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix HTH_38 PF13936.1 KII69397.1 - 0.0042 16.6 0.0 0.077 12.5 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.8 KII69397.1 - 0.0046 16.3 0.1 0.0096 15.3 0.0 1.6 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_IclR PF09339.5 KII69397.1 - 0.0051 16.3 0.0 0.0098 15.4 0.0 1.4 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_Tnp_Tc5 PF03221.11 KII69397.1 - 0.008 15.9 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.1 KII69397.1 - 0.012 15.2 0.0 0.041 13.5 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain HTH_24 PF13412.1 KII69397.1 - 0.028 13.8 0.1 0.14 11.5 0.1 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_psq PF05225.11 KII69397.1 - 0.032 13.7 0.2 0.1 12.1 0.0 1.8 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_26 PF13443.1 KII69397.1 - 0.035 14.3 0.1 0.074 13.2 0.0 1.7 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain HTH_17 PF12728.2 KII69397.1 - 0.59 10.4 0.2 0.59 10.4 0.1 2.2 3 0 0 3 3 3 0 Helix-turn-helix domain PEHE PF15275.1 KII69399.1 - 9.3e-06 26.1 0.2 9.3e-06 26.1 0.1 2.7 2 1 1 3 3 3 1 PEHE domain DUF3365 PF11845.3 KII69399.1 - 0.031 14.1 1.6 1.3 8.8 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3365) DNA_pack_N PF02500.10 KII69399.1 - 0.067 12.7 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus vMSA PF00695.14 KII69399.1 - 0.67 9.0 2.8 1.1 8.4 2.0 1.3 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Lon_C PF05362.8 KII69400.1 - 5.6e-23 81.3 0.2 6.3e-23 81.1 0.2 1.0 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain ChlI PF13541.1 KII69400.1 - 1.7e-06 27.5 0.1 2.2e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase DHQS PF01959.11 KII69400.1 - 0.019 13.6 0.0 0.022 13.4 0.0 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) Ribophorin_I PF04597.9 KII69401.1 - 5.4e-85 285.5 10.4 8.3e-85 284.8 7.2 1.3 1 0 0 1 1 1 1 Ribophorin I IncA PF04156.9 KII69401.1 - 0.013 15.1 1.5 0.022 14.3 1.0 1.4 1 0 0 1 1 1 0 IncA protein Syntaxin-6_N PF09177.6 KII69401.1 - 0.21 12.0 3.0 0.46 10.9 1.0 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Syntaxin PF00804.20 KII69401.1 - 0.25 11.5 7.4 0.14 12.3 2.5 2.3 2 0 0 2 2 2 0 Syntaxin DASH_Dad1 PF08649.5 KII69401.1 - 0.26 10.9 2.2 0.3 10.8 0.2 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad1 DUF148 PF02520.12 KII69401.1 - 1.1 9.0 8.2 0.22 11.3 2.6 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF148 APG6 PF04111.7 KII69401.1 - 6 5.8 12.8 2.3 7.1 6.9 1.7 2 0 0 2 2 2 0 Autophagy protein Apg6 WH1 PF00568.18 KII69405.1 - 9.8e-14 51.0 0.4 1.6e-13 50.3 0.2 1.4 1 1 0 1 1 1 1 WH1 domain DDE_3 PF13358.1 KII69406.1 - 2.2e-07 30.7 0.6 0.004 16.9 0.0 2.7 2 1 1 3 3 3 2 DDE superfamily endonuclease HTH_33 PF13592.1 KII69406.1 - 6.1e-06 25.6 0.0 7.4e-05 22.2 0.0 2.4 3 0 0 3 3 3 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII69406.1 - 0.001 19.1 0.3 0.0027 17.7 0.1 1.8 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.1 KII69406.1 - 0.0037 18.0 0.1 0.0067 17.1 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Pico_P2B PF01552.12 KII69406.1 - 0.064 13.4 0.1 0.14 12.3 0.1 1.7 1 0 0 1 1 1 0 Picornavirus 2B protein HTH_23 PF13384.1 KII69406.1 - 0.078 12.6 0.2 0.25 11.0 0.1 1.8 2 0 0 2 2 2 0 Homeodomain-like domain MULE PF10551.4 KII69408.1 - 1.5e-07 31.5 0.0 3.4e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Kunitz_BPTI PF00014.18 KII69409.1 - 1.1e-24 86.4 23.1 5.3e-13 48.9 5.5 2.1 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Eclosion PF04736.7 KII69409.1 - 7.9 5.9 8.2 0.6 9.5 0.9 2.4 2 1 0 2 2 2 0 Eclosion hormone DUF1232 PF06803.7 KII69411.1 - 4.9e-09 35.4 4.4 4.9e-09 35.4 3.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1232) zf-RING_2 PF13639.1 KII69411.1 - 6.8e-06 25.8 9.8 1.4e-05 24.8 6.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KII69411.1 - 1.1e-05 24.9 7.9 2e-05 24.1 5.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KII69411.1 - 2.1e-05 24.0 10.0 3.9e-05 23.2 6.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KII69411.1 - 0.0087 16.0 10.5 0.02 14.9 7.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KII69411.1 - 0.016 14.9 10.7 0.05 13.3 7.5 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-Apc11 PF12861.2 KII69411.1 - 0.018 14.8 1.8 0.034 13.9 1.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger OppC_N PF12911.2 KII69411.1 - 0.029 13.7 0.1 0.029 13.7 0.1 2.0 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF3317 PF11779.3 KII69411.1 - 0.045 13.2 0.9 0.045 13.2 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3317) zf-rbx1 PF12678.2 KII69411.1 - 0.42 10.7 8.7 1.6 8.8 6.0 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger zf-piccolo PF05715.8 KII69411.1 - 0.49 10.4 5.8 5.5 7.0 2.3 2.3 2 0 0 2 2 2 0 Piccolo Zn-finger zf-MIZ PF02891.15 KII69411.1 - 0.53 9.8 7.4 1.1 8.8 5.1 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_4 PF14570.1 KII69411.1 - 5.7 6.5 11.4 23 4.6 7.9 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain RrnaAD PF00398.15 KII69412.1 - 4e-33 114.5 0.0 5.9e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_28 PF02636.12 KII69412.1 - 0.089 12.1 0.0 1.4 8.2 0.0 2.1 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Metallophos PF00149.23 KII69413.1 - 3.7e-17 62.3 4.0 7e-17 61.4 2.8 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 KII69413.1 - 7.4e-11 41.9 0.6 2.9e-10 40.0 0.0 2.3 3 0 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C PhoD PF09423.5 KII69413.1 - 4.4e-07 28.8 0.1 1.9e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 PhoD-like phosphatase Metallophos_2 PF12850.2 KII69413.1 - 3.5e-05 23.6 0.0 8e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain GNT-I PF03071.10 KII69415.1 - 2.3e-14 52.8 0.2 2.8e-14 52.5 0.1 1.2 1 0 0 1 1 1 1 GNT-I family YhfZ_C PF14503.1 KII69415.1 - 0.08 12.2 0.1 0.29 10.4 0.0 1.8 2 0 0 2 2 2 0 YhfZ C-terminal domain GNT-I PF03071.10 KII69416.1 - 5.7e-60 203.0 0.1 7.2e-60 202.7 0.1 1.0 1 0 0 1 1 1 1 GNT-I family DsrH PF04077.7 KII69418.1 - 0.079 12.6 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 DsrH like protein Aida_N PF08910.5 KII69418.1 - 0.29 11.3 2.3 0.25 11.5 0.6 1.6 2 0 0 2 2 2 0 Aida N-terminus Kelch_6 PF13964.1 KII69419.1 - 2.7e-22 77.9 15.3 0.00037 20.5 0.3 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 KII69419.1 - 3.7e-17 61.9 10.0 0.00093 19.2 0.2 5.7 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 KII69419.1 - 3.2e-14 52.4 18.7 0.0019 17.9 0.6 5.6 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII69419.1 - 1.4e-10 40.5 20.1 0.0014 18.1 0.1 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KII69419.1 - 4.8e-10 38.7 16.3 0.067 12.9 0.2 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.1 KII69419.1 - 4.6e-07 29.6 13.7 0.0062 16.4 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Oscp1 PF10188.4 KII69420.1 - 0.02 14.7 0.0 0.021 14.6 0.0 1.0 1 0 0 1 1 1 0 Organic solute transport protein 1 Kinesin PF00225.18 KII69422.1 - 6.2e-110 367.0 0.8 1.2e-109 366.0 0.6 1.5 1 0 0 1 1 1 1 Kinesin motor domain UpxZ PF06603.6 KII69422.1 - 0.2 11.6 3.5 2.9 7.9 0.0 3.1 3 0 0 3 3 3 0 UpxZ family of transcription anti-terminator antagonists TPR_MLP1_2 PF07926.7 KII69422.1 - 4 7.1 23.0 0.78 9.4 7.9 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein GAGA_bind PF06217.7 KII69423.1 - 0.0052 16.7 1.0 0.0052 16.7 0.7 2.0 2 0 0 2 2 2 1 GAGA binding protein-like family DUF812 PF05667.6 KII69423.1 - 0.067 11.6 26.9 0.011 14.3 8.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Reo_sigmaC PF04582.7 KII69423.1 - 0.25 10.4 10.2 0.49 9.5 2.5 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Filament PF00038.16 KII69423.1 - 0.6 9.5 34.2 0.082 12.3 7.9 3.3 2 1 1 3 3 3 0 Intermediate filament protein DUF883 PF05957.8 KII69423.1 - 0.6 10.5 10.9 11 6.4 0.1 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF2721 PF11026.3 KII69423.1 - 0.63 9.6 1.7 0.9 9.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Spc7 PF08317.6 KII69423.1 - 0.98 8.0 45.3 0.16 10.6 9.8 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.5 KII69423.1 - 1.1 9.3 36.2 0.28 11.2 7.4 3.1 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF4239 PF14023.1 KII69423.1 - 1.9 7.7 11.6 0.41 9.9 3.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) zf-C4H2 PF10146.4 KII69423.1 - 2.4 8.0 28.3 0.13 12.2 7.9 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein ATG16 PF08614.6 KII69423.1 - 2.9 7.6 37.5 0.15 11.9 8.2 3.4 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) SpoIIIAH PF12685.2 KII69423.1 - 3.9 6.9 26.4 2.1 7.8 9.3 2.6 2 1 1 3 3 3 0 SpoIIIAH-like protein DUF1759 PF03564.10 KII69423.1 - 9.2 6.0 24.6 0.98 9.2 2.6 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1759) RPN7 PF10602.4 KII69425.1 - 7.4e-22 77.5 1.9 1e-21 77.1 0.4 1.8 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 KII69425.1 - 7.6e-13 48.6 0.3 2.4e-12 47.1 0.2 1.9 1 0 0 1 1 1 1 PCI domain PCI_Csn8 PF10075.4 KII69425.1 - 0.063 13.0 0.1 0.19 11.4 0.0 1.9 1 0 0 1 1 1 0 COP9 signalosome, subunit CSN8 Annexin PF00191.15 KII69427.1 - 4.9e-28 96.8 6.9 4e-12 45.8 0.2 4.7 4 1 0 4 4 4 4 Annexin Aminotran_1_2 PF00155.16 KII69429.1 - 2.7e-70 237.1 0.0 3.1e-70 236.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 KII69429.1 - 7.7e-08 31.4 0.0 1.1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 KII69429.1 - 0.00012 20.5 0.0 0.00017 19.9 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 KII69429.1 - 0.012 14.7 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase URO-D PF01208.12 KII69430.1 - 7.7e-66 222.3 0.0 9.2e-66 222.0 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) MH1 PF03165.11 KII69431.1 - 1.7e-36 124.3 0.2 4.8e-36 122.8 0.1 1.7 2 0 0 2 2 2 1 MH1 domain MH2 PF03166.9 KII69431.1 - 4.7e-26 91.7 0.0 7.6e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 MH2 domain SH3_9 PF14604.1 KII69432.1 - 6.5e-18 64.0 0.1 1.6e-17 62.8 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 KII69432.1 - 1.2e-14 53.3 0.0 2.4e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 KII69432.1 - 7e-12 44.6 0.1 1.3e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain HTH_23 PF13384.1 KII69434.1 - 3.9e-12 45.3 0.5 4.2e-08 32.5 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII69434.1 - 2.3e-10 40.2 0.3 5.2e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_29 PF13551.1 KII69434.1 - 3.1e-09 36.9 0.5 9.1e-09 35.4 0.2 1.7 1 1 1 2 2 2 1 Winged helix-turn helix PAX PF00292.13 KII69434.1 - 4.4e-08 32.8 0.2 5.6e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_38 PF13936.1 KII69434.1 - 7e-07 28.6 1.3 5e-05 22.7 0.4 2.7 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.1 KII69434.1 - 2.5e-06 26.5 1.7 3.9e-05 22.7 0.0 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 DUF1323 PF07037.6 KII69434.1 - 7.1e-06 26.2 0.3 1.4e-05 25.2 0.2 1.6 1 1 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_Tnp_1 PF01527.15 KII69434.1 - 1.7e-05 24.7 0.2 2.9e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Transposase HTH_Tnp_IS630 PF01710.11 KII69434.1 - 2.1e-05 24.1 0.2 3.2e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Transposase Bot1p PF12298.3 KII69434.1 - 2.4e-05 24.3 1.1 2.9e-05 24.0 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein HTH_32 PF13565.1 KII69434.1 - 2.6e-05 24.9 0.4 0.00039 21.1 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.8 KII69434.1 - 3e-05 23.3 0.9 0.00012 21.4 0.1 2.2 2 1 1 3 3 2 1 CENP-B N-terminal DNA-binding domain HTH_33 PF13592.1 KII69434.1 - 0.00018 20.9 0.0 0.00041 19.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_24 PF13412.1 KII69434.1 - 0.00018 20.7 0.4 0.097 12.0 0.1 2.4 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Tnp_Tc3_2 PF01498.13 KII69434.1 - 0.0002 21.3 0.8 0.0035 17.3 0.0 2.4 2 1 0 2 2 2 1 Transposase Arg_repressor PF01316.16 KII69434.1 - 0.00045 19.7 1.1 0.00086 18.8 0.0 1.9 2 1 1 3 3 3 1 Arginine repressor, DNA binding domain LacI PF00356.16 KII69434.1 - 0.00046 19.7 1.0 1.3 8.6 0.0 3.7 4 0 0 4 4 4 1 Bacterial regulatory proteins, lacI family HTH_17 PF12728.2 KII69434.1 - 0.00091 19.4 0.0 0.2 11.9 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.17 KII69434.1 - 0.0012 18.6 0.0 0.019 14.8 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.1 KII69434.1 - 0.002 17.8 0.6 0.091 12.5 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.10 KII69434.1 - 0.004 16.9 1.7 0.21 11.4 0.2 2.6 2 2 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_40 PF14493.1 KII69434.1 - 0.0054 16.9 0.1 0.011 15.9 0.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 KII69434.1 - 0.0082 15.8 0.2 0.056 13.1 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB SpoIIID PF12116.3 KII69434.1 - 0.016 15.1 1.3 0.18 11.7 0.7 2.3 1 1 0 1 1 1 0 Stage III sporulation protein D Sigma70_r4 PF04545.11 KII69434.1 - 0.021 14.1 0.1 0.05 12.9 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 DUF2666 PF10869.3 KII69434.1 - 0.022 14.8 0.1 0.027 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) HTH_psq PF05225.11 KII69434.1 - 0.028 13.9 0.0 0.064 12.8 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_DeoR PF08220.7 KII69434.1 - 0.032 13.7 0.9 0.2 11.2 0.1 2.3 2 1 0 2 2 2 0 DeoR-like helix-turn-helix domain Sigma70_r4_2 PF08281.7 KII69434.1 - 0.032 13.6 0.0 0.28 10.6 0.0 2.2 2 1 0 2 2 2 0 Sigma-70, region 4 MCR_C PF04609.7 KII69434.1 - 0.033 13.0 0.7 0.038 12.7 0.5 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C HTH_11 PF08279.7 KII69434.1 - 0.038 13.6 1.0 0.096 12.3 0.0 2.2 3 0 0 3 3 2 0 HTH domain Prenyltransf PF01255.14 KII69434.1 - 0.078 12.0 0.2 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase HTH_WhiA PF02650.9 KII69434.1 - 0.09 13.1 0.1 0.86 10.0 0.0 2.0 2 0 0 2 2 2 0 WhiA C-terminal HTH domain FliG_N PF14842.1 KII69434.1 - 0.095 12.8 0.0 0.28 11.2 0.0 1.9 1 1 1 2 2 2 0 FliG N-terminal domain TFIIE_beta PF02186.10 KII69434.1 - 0.099 12.6 0.4 0.22 11.5 0.1 1.7 2 0 0 2 2 2 0 TFIIE beta subunit core domain MarR_2 PF12802.2 KII69434.1 - 0.13 11.9 0.0 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 MarR family DDE_Tnp_IS1595 PF12762.2 KII69437.1 - 2.4e-06 27.4 0.5 2.4e-06 27.4 0.4 1.5 2 0 0 2 2 2 1 ISXO2-like transposase domain DUF4313 PF14190.1 KII69437.1 - 0.095 12.4 0.4 0.46 10.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4313) Glyco_hydro_85 PF03644.8 KII69438.1 - 5e-43 147.4 0.2 6e-43 147.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Glyco_hydro_18 PF00704.23 KII69438.1 - 0.051 13.0 0.0 0.068 12.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 DUF2964 PF11177.3 KII69439.1 - 0.1 12.5 0.3 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2964) Helicase_C_2 PF13307.1 KII69441.1 - 3.6e-13 49.8 0.2 2.9e-12 46.8 0.1 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain Arch_fla_DE PF04659.8 KII69441.1 - 0.039 13.7 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Archaeal flagella protein DEAD_2 PF06733.10 KII69442.1 - 1.1e-41 142.1 4.6 1.8e-41 141.4 3.2 1.4 1 0 0 1 1 1 1 DEAD_2 DUF1227 PF06777.6 KII69442.1 - 1.7e-38 131.6 0.1 3.2e-38 130.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) Helicase_C_2 PF13307.1 KII69442.1 - 3.9e-25 88.7 0.0 1.5e-24 86.8 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD PF00270.24 KII69442.1 - 6.7e-06 25.6 0.0 8.3e-05 22.1 0.0 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.11 KII69442.1 - 0.00023 20.4 0.0 0.019 14.1 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.10 KII69442.1 - 0.0016 18.3 0.3 0.016 15.0 0.2 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KII69442.1 - 0.011 14.5 0.2 0.075 11.8 0.2 2.0 1 1 0 1 1 1 0 SNF2 family N-terminal domain AAA_11 PF13086.1 KII69442.1 - 0.022 14.3 0.1 0.034 13.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain TLE_N PF03920.10 KII69444.1 - 1e-20 73.9 1.0 1.9e-20 73.0 0.7 1.4 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.27 KII69444.1 - 2.7e-20 71.4 20.2 0.00025 20.7 0.1 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat DUF2353 PF09789.4 KII69444.1 - 0.044 13.0 0.1 0.073 12.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) HALZ PF02183.13 KII69444.1 - 0.19 11.4 0.3 0.52 10.0 0.2 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper DivIVA PF05103.8 KII69444.1 - 0.33 10.9 1.7 0.41 10.6 0.1 1.8 2 0 0 2 2 2 0 DivIVA protein HemolysinCabind PF00353.14 KII69444.1 - 7.5 7.2 7.2 18 6.0 5.0 1.7 1 0 0 1 1 1 0 Hemolysin-type calcium-binding repeat (2 copies) MULE PF10551.4 KII69445.1 - 0.00043 20.3 0.2 0.00082 19.4 0.1 1.5 1 1 0 1 1 1 1 MULE transposase domain RtcB PF01139.12 KII69446.1 - 1.9e-28 99.6 0.0 2e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB DNA_pol_B PF00136.16 KII69447.1 - 5.6e-142 473.8 0.6 7.5e-142 473.3 0.4 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 KII69447.1 - 1.9e-59 201.1 0.1 3.2e-59 200.4 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 KII69447.1 - 4.4e-08 33.0 10.0 1e-07 31.8 6.9 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.8 KII69447.1 - 0.0005 18.8 2.0 0.0013 17.5 0.1 2.2 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral zf-RING_3 PF14369.1 KII69447.1 - 0.33 10.9 6.7 3.1 7.8 0.2 2.8 2 0 0 2 2 2 0 zinc-finger RRN3 PF05327.6 KII69449.1 - 3.6e-59 200.3 2.0 4.5e-58 196.7 1.4 1.9 1 1 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Mannosyl_trans2 PF04188.8 KII69449.1 - 0.022 13.6 2.0 0.033 13.1 1.4 1.2 1 0 0 1 1 1 0 Mannosyltransferase (PIG-V)) DltD_C PF04914.7 KII69450.1 - 0.12 12.2 0.2 3.7 7.4 0.0 2.2 1 1 1 2 2 2 0 DltD C-terminal region Benyvirus_14KDa PF07255.6 KII69454.1 - 0.05 13.4 0.4 0.2 11.5 0.2 2.1 1 1 1 2 2 2 0 Benyvirus 14KDa protein rve PF00665.21 KII69456.1 - 1.2e-12 47.9 0.0 2.5e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69456.1 - 0.0056 16.1 0.0 0.013 15.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DUF447 PF04289.7 KII69457.1 - 0.0029 17.2 0.0 0.12 11.9 0.0 2.4 2 1 1 3 3 3 2 Protein of unknown function (DUF447) DUF4206 PF13901.1 KII69462.1 - 0.00032 20.2 0.6 0.0006 19.4 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4206) zinc_ribbon_5 PF13719.1 KII69462.1 - 0.0093 15.5 1.1 0.025 14.1 0.8 1.8 1 0 0 1 1 1 1 zinc-ribbon domain Zn-ribbon_8 PF09723.5 KII69462.1 - 0.02 14.8 0.7 0.062 13.2 0.2 2.0 2 0 0 2 2 2 0 Zinc ribbon domain zinc_ribbon_4 PF13717.1 KII69462.1 - 0.045 13.4 1.6 0.12 12.1 1.1 1.8 1 0 0 1 1 1 0 zinc-ribbon domain zf-H2C2_2 PF13465.1 KII69462.1 - 2.1 8.7 4.6 4.9 7.6 0.2 2.9 2 0 0 2 2 2 0 Zinc-finger double domain zf-RING_3 PF14369.1 KII69462.1 - 7.8 6.5 6.6 51 3.9 0.4 2.7 2 1 1 3 3 3 0 zinc-finger DUF4227 PF14004.1 KII69463.1 - 0.17 11.7 0.4 0.28 11.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) RuvA_N PF01330.16 KII69464.1 - 0.11 12.3 0.1 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 RuvA N terminal domain Acetyltransf_13 PF13880.1 KII69466.1 - 0.073 12.8 0.5 10 5.9 0.1 2.6 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase TBPIP_N PF15517.1 KII69467.1 - 0.028 14.0 0.3 0.057 13.0 0.2 1.6 1 1 0 1 1 1 0 TBP-interacting protein N-terminus Spc97_Spc98 PF04130.8 KII69468.1 - 2.5e-34 118.5 4.6 3.8e-34 117.9 3.2 1.3 1 0 0 1 1 1 1 Spc97 / Spc98 family ANTH PF07651.11 KII69468.1 - 0.0037 16.0 0.1 0.0059 15.3 0.1 1.3 1 0 0 1 1 1 1 ANTH domain DUF963 PF06131.6 KII69468.1 - 0.029 13.6 0.6 0.047 12.9 0.4 1.4 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) Aa_trans PF01490.13 KII69468.1 - 0.068 11.6 2.0 0.1 11.0 1.4 1.2 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein Spc97_Spc98 PF04130.8 KII69469.1 - 5.9e-15 54.5 3.1 1e-11 43.8 0.4 2.2 1 1 1 2 2 2 2 Spc97 / Spc98 family PRA-PH PF01503.12 KII69469.1 - 0.038 14.2 0.0 0.075 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase Ank_2 PF12796.2 KII69471.1 - 1.1e-128 419.9 39.3 1e-20 73.8 0.0 11.2 4 2 7 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.25 KII69471.1 - 1.6e-110 355.8 24.0 3.2e-08 32.9 0.0 21.8 23 0 0 23 23 23 18 Ankyrin repeat Ank_4 PF13637.1 KII69471.1 - 7.6e-85 277.9 8.4 4.7e-15 55.6 0.0 13.9 9 3 7 16 16 16 13 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII69471.1 - 9.8e-83 263.7 24.5 7.9e-07 28.7 0.0 21.7 22 0 0 22 22 22 15 Ankyrin repeat Ank_5 PF13857.1 KII69471.1 - 5.4e-65 213.9 20.6 7.5e-09 35.5 0.2 16.8 6 4 12 19 19 19 12 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 KII69471.1 - 0.0016 18.0 4.0 2.2 7.6 0.0 4.8 6 0 0 6 6 6 2 Shigella flexneri OspC protein KH_1 PF00013.24 KII69472.1 - 4.5e-11 42.2 1.1 8.2e-11 41.3 0.4 1.8 2 0 0 2 2 2 1 KH domain KH_3 PF13014.1 KII69472.1 - 7e-09 35.1 0.2 1.6e-08 33.9 0.2 1.7 1 0 0 1 1 1 1 KH domain DUF4414 PF14377.1 KII69472.1 - 0.0064 16.3 2.7 0.0064 16.3 1.9 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4414) Mitofilin PF09731.4 KII69472.1 - 2.2 6.8 15.0 3.2 6.2 10.4 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein MCPVI PF02993.9 KII69472.1 - 4.9 7.2 25.7 1.1 9.3 12.2 2.6 2 0 0 2 2 2 0 Minor capsid protein VI DUF4130 PF13566.1 KII69474.1 - 1.3 8.5 6.6 2.1 7.8 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4130 KfrA_N PF11740.3 KII69474.1 - 2.1 8.8 5.9 0.52 10.7 1.3 1.8 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term MCLC PF05934.6 KII69475.1 - 0.21 9.8 0.7 0.22 9.7 0.5 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) DDE_3 PF13358.1 KII69479.1 - 0.052 13.2 0.0 0.08 12.6 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII69481.1 - 0.0025 17.5 0.0 0.0073 16.1 0.0 1.9 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain Tim17 PF02466.14 KII69482.1 - 0.0069 16.4 0.0 0.0075 16.3 0.0 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family SRI PF08236.6 KII69483.1 - 0.0095 15.8 1.4 0.013 15.4 1.0 1.4 1 1 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain ICE2 PF08426.5 KII69483.1 - 0.071 11.7 0.2 0.079 11.5 0.1 1.0 1 0 0 1 1 1 0 ICE2 DWNN PF08783.6 KII69485.1 - 3.1e-23 81.4 0.1 7.3e-23 80.3 0.1 1.7 1 0 0 1 1 1 1 DWNN domain zf-C3HC4_2 PF13923.1 KII69485.1 - 3.2e-06 27.0 10.9 3.2e-06 27.0 7.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.18 KII69485.1 - 3.3e-05 23.6 0.5 3.3e-05 23.6 0.4 1.8 2 0 0 2 2 1 1 Zinc knuckle zf-C3HC4 PF00097.20 KII69485.1 - 0.00038 20.0 9.7 0.00038 20.0 6.7 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.10 KII69485.1 - 0.00038 20.3 0.0 0.0011 18.8 0.0 1.8 1 0 0 1 1 1 1 U-box domain DUF869 PF05911.6 KII69485.1 - 0.0012 17.2 0.1 0.0012 17.2 0.1 1.6 2 0 0 2 2 2 1 Plant protein of unknown function (DUF869) zf-RING_6 PF14835.1 KII69485.1 - 0.0012 18.5 5.5 0.0026 17.4 3.8 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.1 KII69485.1 - 0.0014 18.2 13.3 0.011 15.3 6.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KII69485.1 - 0.0035 17.1 8.3 0.0035 17.1 5.7 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 KII69485.1 - 0.004 16.8 9.8 0.004 16.8 6.8 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KII69485.1 - 0.039 13.8 11.6 0.088 12.7 8.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-CCHC_4 PF14392.1 KII69485.1 - 0.082 12.5 4.3 0.062 12.9 1.0 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.1 KII69485.1 - 0.9 9.0 8.9 0.13 11.7 1.9 2.4 2 0 0 2 2 2 0 Zinc knuckle Rtf2 PF04641.7 KII69485.1 - 6.3 5.9 11.7 1.7 7.7 0.3 2.5 2 0 0 2 2 2 0 Rtf2 RING-finger DDE_3 PF13358.1 KII69486.1 - 7.6e-23 80.8 0.1 8.8e-23 80.6 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII69486.1 - 0.036 14.1 0.0 0.05 13.7 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain XFP PF03894.10 KII69486.1 - 0.063 12.8 0.0 0.077 12.5 0.0 1.1 1 0 0 1 1 1 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase DDE_1 PF03184.14 KII69486.1 - 0.081 12.0 0.0 0.091 11.8 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease TPR_11 PF13414.1 KII69488.1 - 1.3e-07 31.1 3.0 0.00023 20.7 0.1 3.0 1 1 2 3 3 3 2 TPR repeat TPR_14 PF13428.1 KII69488.1 - 0.0031 17.9 0.0 0.16 12.6 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TOM20_plant PF06552.7 KII69488.1 - 0.0038 16.8 0.4 0.38 10.3 0.1 2.5 1 1 1 2 2 2 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_19 PF14559.1 KII69488.1 - 0.0041 17.4 0.1 0.26 11.6 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII69488.1 - 0.0045 16.8 2.3 2.5 8.2 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 KII69488.1 - 0.057 13.6 0.2 22 5.5 0.1 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat HCaRG PF07258.9 KII69488.1 - 0.1 12.1 1.2 0.19 11.2 0.1 2.0 2 0 0 2 2 2 0 HCaRG protein TPR_1 PF00515.23 KII69488.1 - 0.14 11.8 0.9 9.6 6.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.17 KII69490.1 - 3.3e-12 45.8 0.1 3.5e-07 29.7 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII69490.1 - 1e-09 38.2 0.1 3.2e-05 23.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Myotub-related PF06602.9 KII69491.1 - 2e-57 194.5 0.1 2.9e-57 194.0 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain MCM PF00493.18 KII69494.1 - 5.8e-14 51.6 0.1 7.8e-14 51.2 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family HTH_Tnp_Tc3_2 PF01498.13 KII69495.1 - 0.1 12.6 0.2 18 5.4 0.1 2.6 2 1 0 2 2 2 0 Transposase zf-H2C2_2 PF13465.1 KII69496.1 - 1.7e-16 59.6 27.2 1.4e-07 31.4 1.4 5.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.21 KII69496.1 - 6.5e-15 54.4 29.2 2.9e-05 24.1 0.3 4.7 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII69496.1 - 3.1e-14 52.1 19.3 0.00035 20.6 0.2 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger BLVR PF06375.6 KII69496.1 - 0.0056 16.5 2.7 0.0091 15.8 1.9 1.3 1 0 0 1 1 1 1 Bovine leukaemia virus receptor (BLVR) zf-TRAF PF02176.13 KII69496.1 - 0.07 13.5 17.5 0.44 10.9 3.2 3.6 2 1 3 5 5 4 0 TRAF-type zinc finger zf-C2H2_jaz PF12171.3 KII69496.1 - 0.12 12.5 0.7 0.12 12.5 0.5 4.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KII69496.1 - 0.53 10.5 0.0 0.53 10.5 0.0 4.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type CCAP PF11105.3 KII69496.1 - 0.55 9.9 10.1 1.3 8.7 0.2 2.8 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a DUF116 PF01976.12 KII69496.1 - 0.7 9.3 5.9 0.64 9.4 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF116 zf-C2HC_2 PF13913.1 KII69496.1 - 0.85 9.3 0.1 0.85 9.3 0.1 4.1 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Zn_Tnp_IS1595 PF12760.2 KII69496.1 - 1 9.2 5.2 4.3 7.2 1.4 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Transpos_assoc PF13963.1 KII69496.1 - 1.7 8.7 9.1 0.93 9.5 0.1 3.1 2 1 1 3 3 3 0 Transposase-associated domain zf-met2 PF12907.2 KII69496.1 - 4.7 7.2 8.4 47 4.0 0.5 2.8 2 1 1 3 3 3 0 Zinc-binding Pneumo_M2 PF07380.6 KII69497.1 - 0.11 12.4 0.4 0.2 11.6 0.3 1.4 1 0 0 1 1 1 0 Pneumovirus M2 protein NTR PF01759.16 KII69499.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 UNC-6/NTR/C345C module HEAT PF02985.17 KII69500.1 - 3.3e-07 29.8 0.2 0.83 9.8 0.0 3.5 3 0 0 3 3 3 3 HEAT repeat HEAT_2 PF13646.1 KII69500.1 - 4.4e-05 23.6 0.0 0.0014 18.8 0.0 2.4 1 1 1 2 2 2 2 HEAT repeats Cohesin_HEAT PF12765.2 KII69500.1 - 0.00011 22.0 0.3 0.041 13.8 0.1 2.9 2 1 0 2 2 2 2 HEAT repeat associated with sister chromatid cohesion PsbQ PF05757.6 KII69501.1 - 0.051 12.9 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) HMG_box PF00505.14 KII69502.1 - 1.3e-19 70.2 3.5 1.9e-19 69.7 1.3 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KII69502.1 - 2.3e-07 31.0 1.2 4.9e-07 30.0 0.8 1.6 1 0 0 1 1 1 1 HMG-box domain PepSY_TM_3 PF13706.1 KII69503.1 - 0.011 15.0 0.2 0.024 14.0 0.2 1.6 1 0 0 1 1 1 0 PepSY-associated TM helix DUF4476 PF14771.1 KII69503.1 - 0.014 15.4 0.1 0.062 13.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4476) Sperm_Ag_HE2 PF05324.8 KII69503.1 - 0.15 11.9 0.1 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 Sperm antigen HE2 GH97_C PF14509.1 KII69504.1 - 0.071 13.2 0.2 0.34 11.0 0.0 1.8 1 1 1 2 2 2 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation DUF1874 PF08960.5 KII69505.1 - 0.013 15.1 0.1 0.02 14.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1874) HTH_32 PF13565.1 KII69505.1 - 0.025 15.3 0.1 0.042 14.6 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Tn7_Tnp_TnsA_C PF08721.6 KII69505.1 - 0.065 13.2 0.1 4.9 7.2 0.0 2.2 2 0 0 2 2 2 0 TnsA endonuclease C terminal CodY PF06018.9 KII69506.1 - 0.017 14.3 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 CodY GAF-like domain SNAP PF14938.1 KII69509.1 - 0.00019 20.6 0.1 0.00022 20.4 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NAGLU_C PF12972.2 KII69509.1 - 0.02 14.3 0.1 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain RRM_1 PF00076.17 KII69510.1 - 3.1e-24 84.4 0.0 5.5e-24 83.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.1 KII69510.1 - 6.7e-23 80.5 0.7 1.3e-22 79.6 0.5 1.5 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_6 PF14259.1 KII69510.1 - 1.8e-17 63.0 0.0 4.7e-17 61.7 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII69510.1 - 2.5e-09 36.8 0.0 3.9e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDE_3 PF13358.1 KII69512.1 - 0.079 12.7 0.1 0.098 12.4 0.0 1.3 1 1 0 1 1 1 0 DDE superfamily endonuclease FH2 PF02181.18 KII69514.1 - 4.9e-39 134.2 4.2 5.6e-39 134.0 2.9 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain FliG_M PF14841.1 KII69515.1 - 0.053 13.5 0.1 16 5.5 0.1 2.4 2 0 0 2 2 2 0 FliG middle domain E2 PF08199.6 KII69515.1 - 0.062 12.9 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage E2-like protein rve_3 PF13683.1 KII69518.1 - 0.029 13.8 0.0 0.092 12.2 0.0 1.8 2 0 0 2 2 2 0 Integrase core domain rve PF00665.21 KII69518.1 - 0.052 13.6 0.0 0.067 13.3 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain HTH_33 PF13592.1 KII69520.1 - 9.6e-05 21.8 0.0 0.0002 20.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII69520.1 - 0.00096 19.1 0.1 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Transposase DDE_3 PF13358.1 KII69520.1 - 0.0054 16.4 0.0 0.009 15.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BNR PF02012.15 KII69525.1 - 0.098 12.5 0.1 19 5.6 0.0 3.1 2 0 0 2 2 2 0 BNR/Asp-box repeat PAP_assoc PF03828.14 KII69526.1 - 0.005 16.7 0.3 0.034 14.1 0.0 2.1 2 0 0 2 2 2 1 Cid1 family poly A polymerase Med26 PF08711.6 KII69528.1 - 6.8e-11 41.5 2.5 1.5e-10 40.4 1.7 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain MTBP_mid PF14919.1 KII69528.1 - 0.0018 17.0 0.2 0.0022 16.7 0.2 1.1 1 0 0 1 1 1 1 MDM2-binding Microtub_bind PF13931.1 KII69528.1 - 0.19 11.8 2.7 0.84 9.7 0.1 2.3 1 1 1 2 2 2 0 Kinesin-associated microtubule-binding Hydrolase_like PF13242.1 KII69530.1 - 0.0094 15.6 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Tetraspannin PF00335.15 KII69531.1 - 2.4e-13 49.8 9.9 3.2e-13 49.4 6.8 1.0 1 0 0 1 1 1 1 Tetraspanin family RTC_insert PF05189.8 KII69532.1 - 1.1e-11 44.5 0.0 1.4e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.16 KII69532.1 - 0.021 13.6 0.0 0.021 13.6 0.0 1.1 1 0 0 1 1 1 0 RNA 3'-terminal phosphate cyclase RTC PF01137.16 KII69533.1 - 1.9e-27 95.5 0.0 2.1e-27 95.3 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase zf-RING_2 PF13639.1 KII69534.1 - 0.0064 16.3 2.0 0.0065 16.2 0.2 2.0 2 0 0 2 2 2 1 Ring finger domain ELL PF10390.4 KII69534.1 - 0.092 11.9 0.1 0.19 10.8 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL zf-UBR PF02207.15 KII69535.1 - 4.5e-15 55.1 14.1 4.5e-15 55.1 9.8 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) SH3_6 PF12913.2 KII69536.1 - 0.052 12.7 0.0 0.11 11.7 0.0 1.6 1 1 0 1 1 1 0 SH3 domain of the SH3b1 type Adaptin_N PF01602.15 KII69537.1 - 1.1e-12 47.1 0.3 1.4e-12 46.7 0.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Proho_convert PF12177.3 KII69538.1 - 2.1 7.9 5.1 0.29 10.7 0.2 1.8 2 0 0 2 2 2 0 Prohormone convertase enzyme DDE_3 PF13358.1 KII69540.1 - 1.9e-06 27.6 0.0 5.5e-06 26.1 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF639 PF04842.7 KII69541.1 - 0.047 11.8 0.2 0.059 11.5 0.2 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) DUF4296 PF14129.1 KII69542.1 - 0.15 12.2 2.6 0.24 11.5 0.7 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4296) SNAP PF14938.1 KII69545.1 - 0.00039 19.6 0.8 0.00043 19.5 0.6 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII69545.1 - 7 6.8 8.5 14 5.8 0.3 4.3 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF3305 PF11749.3 KII69546.1 - 0.034 14.0 0.0 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3305) Poly_export PF02563.11 KII69548.1 - 0.069 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis/export protein HTH_32 PF13565.1 KII69549.1 - 2e-09 38.0 0.0 6.6e-08 33.2 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII69549.1 - 5.3e-08 33.0 0.1 7.9e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII69549.1 - 3e-07 29.8 0.0 9.4e-07 28.2 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII69549.1 - 5e-06 26.3 0.3 7e-05 22.7 0.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII69549.1 - 0.00044 19.9 0.5 0.00073 19.2 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.1 KII69549.1 - 0.0021 17.5 0.0 0.005 16.3 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn helix HTH_40 PF14493.1 KII69549.1 - 0.0037 17.4 0.4 0.011 15.8 0.1 1.9 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.15 KII69549.1 - 0.0093 15.8 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc3_2 PF01498.13 KII69549.1 - 0.01 15.8 0.8 0.058 13.4 0.0 2.5 3 0 0 3 3 3 0 Transposase PAX PF00292.13 KII69549.1 - 0.012 15.3 0.1 0.025 14.3 0.1 1.5 1 0 0 1 1 1 0 'Paired box' domain Toxin_64 PF15542.1 KII69549.1 - 0.013 16.0 5.4 0.99 10.0 1.1 2.6 1 1 1 2 2 2 0 Putative toxin 64 TrmB PF01978.14 KII69549.1 - 0.015 15.0 0.1 0.037 13.7 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.5 KII69549.1 - 0.17 11.5 0.0 0.77 9.3 0.0 2.0 2 1 0 2 2 2 0 IclR helix-turn-helix domain PAT1 PF09770.4 KII69550.1 - 3 5.9 24.7 3.2 5.8 17.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RRM_6 PF14259.1 KII69551.1 - 6.4e-17 61.3 0.0 1.6e-16 60.0 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII69551.1 - 3.4e-15 55.4 0.0 6.4e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII69551.1 - 7.9e-10 38.4 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII69551.1 - 0.023 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF4611 PF15387.1 KII69551.1 - 0.061 13.4 0.5 0.099 12.7 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Histone PF00125.19 KII69553.1 - 9.6e-22 76.9 0.2 1.6e-21 76.2 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KII69553.1 - 0.037 14.0 0.4 0.16 12.0 0.3 2.2 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PCI PF01399.22 KII69557.1 - 2.2e-12 47.1 3.1 2.8e-12 46.8 0.2 2.5 2 1 0 2 2 2 1 PCI domain ERp29 PF07749.7 KII69557.1 - 0.0016 19.0 1.1 0.1 13.2 0.0 3.4 3 0 0 3 3 3 1 Endoplasmic reticulum protein ERp29, C-terminal domain EF-hand_2 PF09068.6 KII69557.1 - 0.013 15.6 0.3 0.18 11.8 0.0 2.6 2 0 0 2 2 2 0 EF hand Nicastrin PF05450.10 KII69560.1 - 8.3e-33 113.5 0.0 1e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 Nicastrin MH2 PF03166.9 KII69560.1 - 0.05 13.4 0.0 0.074 12.8 0.0 1.2 1 0 0 1 1 1 0 MH2 domain RRM_1 PF00076.17 KII69564.1 - 7.3e-11 41.5 0.1 1.2e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII69564.1 - 1.3e-09 37.8 0.0 2.8e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII69564.1 - 6.5e-05 22.6 0.1 0.00018 21.2 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HECT PF00632.20 KII69565.1 - 9.4e-85 284.5 0.5 1.1e-84 284.2 0.3 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) EF1G PF00647.14 KII69565.1 - 0.025 14.2 0.3 0.063 12.9 0.2 1.6 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain WW PF00397.21 KII69566.1 - 1.6e-06 27.8 0.2 0.0064 16.3 0.1 2.5 2 0 0 2 2 2 2 WW domain DivIC PF04977.10 KII69566.1 - 0.14 11.6 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Septum formation initiator Ion_trans_2 PF07885.11 KII69567.1 - 6.9e-07 28.8 7.5 2.3e-06 27.2 5.2 1.9 1 1 0 1 1 1 1 Ion channel RtcR PF06956.6 KII69567.1 - 0.067 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Regulator of RNA terminal phosphate cyclase DUF1049 PF06305.6 KII69567.1 - 0.16 11.4 0.4 1.4 8.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) HTH_Tnp_IS630 PF01710.11 KII69571.1 - 4.8e-06 26.2 1.3 6.7e-06 25.7 0.9 1.3 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII69571.1 - 0.0002 22.0 0.2 0.00047 20.9 0.1 1.6 1 1 0 1 1 1 1 Homeodomain-like domain HTH_33 PF13592.1 KII69571.1 - 0.00025 20.5 0.0 0.00045 19.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII69571.1 - 0.0027 17.2 0.4 0.043 13.4 0.0 2.8 2 1 1 3 3 3 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII69571.1 - 0.004 17.1 0.4 0.0093 16.0 0.3 1.6 1 0 0 1 1 1 1 Transposase Arg_repressor PF01316.16 KII69571.1 - 0.0063 16.0 0.5 0.014 14.9 0.3 1.6 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain HTH_29 PF13551.1 KII69571.1 - 0.0064 16.6 0.3 0.015 15.4 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_psq PF05225.11 KII69571.1 - 0.058 12.9 0.0 0.29 10.7 0.0 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_28 PF13518.1 KII69571.1 - 0.073 13.0 0.1 0.44 10.5 0.0 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain gag-asp_proteas PF13975.1 KII69574.1 - 0.00041 20.0 0.4 0.00097 18.9 0.3 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII69574.1 - 0.0024 18.3 0.2 0.0053 17.2 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII69574.1 - 0.021 14.7 0.0 0.044 13.7 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease DDE_3 PF13358.1 KII69575.1 - 2.9e-18 66.0 0.2 3.5e-18 65.7 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Mac-1 PF09028.5 KII69575.1 - 0.039 12.7 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Mac 1 HTH_23 PF13384.1 KII69576.1 - 0.16 11.6 0.1 0.36 10.5 0.0 1.6 2 0 0 2 2 2 0 Homeodomain-like domain ArsC PF03960.10 KII69580.1 - 0.04 13.9 0.1 0.15 12.1 0.0 1.9 1 1 0 1 1 1 0 ArsC family rve PF00665.21 KII69581.1 - 2.1e-20 72.9 0.0 4.3e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69581.1 - 0.00039 19.8 0.1 0.00086 18.7 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Inhibitor_I67 PF11405.3 KII69581.1 - 7.8 6.6 7.7 0.42 10.6 0.8 2.2 2 0 0 2 2 2 0 Bromelain inhibitor VI TOH_N PF12549.3 KII69587.1 - 0.075 12.6 1.1 0.59 9.7 0.0 2.2 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal Flp_N PF03930.9 KII69588.1 - 0.058 13.1 1.1 0.11 12.2 0.8 1.5 1 0 0 1 1 1 0 Recombinase Flp protein N-terminus TLD PF07534.11 KII69589.1 - 7.7e-19 68.0 0.6 9.3e-19 67.8 0.4 1.0 1 0 0 1 1 1 1 TLD DUF3223 PF11523.3 KII69589.1 - 0.12 12.6 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3223) GATA PF00320.22 KII69591.1 - 3.5e-15 55.0 6.6 3.5e-15 55.0 4.6 2.0 2 0 0 2 2 2 1 GATA zinc finger zf-UBP PF02148.14 KII69591.1 - 0.35 11.0 7.6 0.74 9.9 1.3 2.5 1 1 1 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein FYVE PF01363.16 KII69591.1 - 0.8 9.6 14.2 10 6.1 9.9 2.4 1 1 1 2 2 2 0 FYVE zinc finger TF_Zn_Ribbon PF08271.7 KII69591.1 - 0.85 8.9 12.8 0.47 9.8 2.7 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding zf-TFIIB PF13453.1 KII69591.1 - 2.6 7.3 5.9 1.5 8.0 0.3 2.5 1 1 1 2 2 2 0 Transcription factor zinc-finger DUF2296 PF10058.4 KII69592.1 - 0.012 15.3 1.4 0.04 13.6 0.9 1.9 1 0 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) zf-TFIIB PF13453.1 KII69592.1 - 0.083 12.0 0.3 0.17 11.1 0.2 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger FYVE PF01363.16 KII69592.1 - 0.14 12.0 1.5 1.5 8.7 0.5 2.3 1 1 1 2 2 2 0 FYVE zinc finger B56 PF01603.15 KII69593.1 - 0.0058 15.2 0.2 0.006 15.2 0.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) IBN_N PF03810.14 KII69593.1 - 0.039 13.8 0.6 2.2 8.2 0.1 2.1 1 1 1 2 2 2 0 Importin-beta N-terminal domain DDE_Tnp_IS1595 PF12762.2 KII69594.1 - 0.00032 20.5 0.0 0.00043 20.1 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain Vps26 PF03643.10 KII69595.1 - 0.012 14.3 0.2 0.013 14.2 0.1 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 rve PF00665.21 KII69598.1 - 0.0002 21.4 0.0 0.00061 19.8 0.0 1.8 3 0 0 3 3 3 1 Integrase core domain Nop53 PF07767.6 KII69600.1 - 0.023 13.7 0.0 0.028 13.3 0.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) NADH_dehy_S2_C PF06444.6 KII69600.1 - 0.061 13.6 0.0 0.093 13.0 0.0 1.3 1 0 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus SNAP PF14938.1 KII69601.1 - 0.0018 17.4 0.7 0.002 17.3 0.5 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RSS_P20 PF11757.3 KII69601.1 - 0.064 13.3 0.4 0.099 12.7 0.3 1.3 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like SNAP PF14938.1 KII69602.1 - 1.4e-11 44.0 3.3 2.6e-11 43.2 2.3 1.4 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII69602.1 - 0.0023 17.5 1.3 0.8 9.3 1.7 2.6 2 0 0 2 2 2 2 TPR repeat DUF3276 PF11680.3 KII69602.1 - 0.014 15.2 2.3 0.034 13.9 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) EST1_DNA_bind PF10373.4 KII69602.1 - 0.084 12.0 1.0 0.14 11.3 0.6 1.4 1 1 0 1 1 1 0 Est1 DNA/RNA binding domain Spy1 PF11357.3 KII69605.1 - 0.023 14.7 0.2 0.031 14.3 0.2 1.2 1 0 0 1 1 1 0 Cell cycle regulatory protein EPL1 PF10513.4 KII69606.1 - 7.8e-12 45.7 8.4 9.2e-10 38.9 1.1 4.1 3 1 0 3 3 3 1 Enhancer of polycomb-like Lge1 PF11488.3 KII69606.1 - 0.07 13.3 1.1 0.36 11.0 0.8 2.3 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 MENTAL PF10457.4 KII69607.1 - 0.054 13.1 2.2 0.068 12.7 1.5 1.2 1 0 0 1 1 1 0 Cholesterol-capturing domain PAXNEB PF05625.6 KII69607.1 - 0.11 11.2 0.5 0.12 11.1 0.4 1.1 1 0 0 1 1 1 0 PAXNEB protein zf-BED PF02892.10 KII69608.1 - 0.00071 19.2 0.9 0.0021 17.7 0.6 1.8 1 0 0 1 1 1 1 BED zinc finger DUF4451 PF14616.1 KII69608.1 - 0.075 12.7 0.2 0.8 9.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4451) MA-Mit PF09245.5 KII69609.1 - 0.081 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen Asp PF00026.18 KII69610.1 - 3.4e-96 322.2 1.1 4.2e-96 321.9 0.7 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KII69610.1 - 1.2e-06 28.5 0.0 2.1e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 KII69610.1 - 0.0066 16.9 0.2 2.6 8.5 0.0 3.2 2 1 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.1 KII69610.1 - 0.089 12.3 0.1 0.38 10.2 0.0 2.0 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Herpes_UL49_1 PF03117.9 KII69612.1 - 0.038 13.0 0.1 0.049 12.7 0.1 1.2 1 0 0 1 1 1 0 UL49 family Gelsolin PF00626.17 KII69613.1 - 1.6e-38 130.2 0.0 6.9e-14 51.3 0.0 3.2 3 0 0 3 3 3 3 Gelsolin repeat DCX PF03607.12 KII69614.1 - 2.1e-08 33.6 0.1 2.7e-06 26.8 0.0 2.3 2 0 0 2 2 2 2 Doublecortin CENP_C_N PF15622.1 KII69614.1 - 0.0013 18.0 0.6 0.002 17.4 0.4 1.3 1 0 0 1 1 1 1 Kinetochore assembly subunit CENP-C N-terminal ASRT PF07100.6 KII69614.1 - 0.12 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Anabaena sensory rhodopsin transducer DUF4463 PF14703.1 KII69614.1 - 0.27 11.7 3.2 0.68 10.4 2.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4463) DUF4455 PF14643.1 KII69615.1 - 0.035 12.7 0.3 0.044 12.4 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) Mod_r PF07200.8 KII69615.1 - 0.077 12.9 0.3 0.094 12.6 0.2 1.1 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein RICH PF05062.7 KII69615.1 - 0.078 13.1 1.1 0.12 12.5 0.7 1.3 1 0 0 1 1 1 0 RICH domain DUF919 PF06034.6 KII69615.1 - 0.72 9.5 5.2 0.33 10.6 1.4 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Lectin_leg-like PF03388.8 KII69616.1 - 1.9e-37 128.6 1.1 2.1e-37 128.4 0.7 1.0 1 0 0 1 1 1 1 Legume-like lectin family DUF3733 PF12534.3 KII69616.1 - 0.095 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat containing protein 8 Clathrin_lg_ch PF01086.12 KII69617.1 - 8.5e-06 25.8 16.3 1e-05 25.5 11.3 1.0 1 0 0 1 1 1 1 Clathrin light chain V-ATPase_G PF03179.10 KII69617.1 - 0.35 11.1 14.8 0.042 14.1 6.7 1.8 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit DUF4653 PF15546.1 KII69617.1 - 0.36 10.0 6.9 0.74 9.0 4.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4653) PCRF PF03462.13 KII69617.1 - 2.3 7.9 6.9 2.4 7.9 2.9 2.0 1 1 1 2 2 2 0 PCRF domain IncA PF04156.9 KII69617.1 - 3.1 7.3 9.3 3.5 7.1 5.9 1.4 1 1 0 1 1 1 0 IncA protein DUF4259 PF14078.1 KII69617.1 - 3.5 8.1 7.5 4.7 7.7 5.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4259) DivIC PF04977.10 KII69617.1 - 3.9 7.0 9.8 1.8 8.0 5.2 1.7 2 0 0 2 2 2 0 Septum formation initiator AIF-MLS PF14962.1 KII69617.1 - 4.8 6.7 9.5 5.5 6.5 6.6 1.2 1 0 0 1 1 1 0 Mitochondria Localisation Sequence AAA_13 PF13166.1 KII69617.1 - 6.5 5.0 14.9 6.8 5.0 10.3 1.0 1 0 0 1 1 1 0 AAA domain Frag1 PF10277.4 KII69618.1 - 0.00014 21.4 9.8 0.00015 21.2 6.8 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Xan_ur_permease PF00860.15 KII69618.1 - 0.011 14.1 1.1 0.016 13.7 0.8 1.4 1 1 0 1 1 1 0 Permease family DUF998 PF06197.8 KII69618.1 - 0.012 14.9 0.3 0.014 14.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF998) Claudin_2 PF13903.1 KII69618.1 - 0.22 11.2 5.0 0.32 10.6 3.4 1.4 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction ATP_synt_I PF03899.10 KII69618.1 - 0.4 10.8 7.6 1 9.5 5.3 1.7 1 1 0 1 1 1 0 ATP synthase I chain Cation_ATPase_C PF00689.16 KII69618.1 - 1 8.8 5.9 1.2 8.6 4.1 1.1 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus GWT1 PF06423.7 KII69618.1 - 1.9 8.5 6.7 2.7 8.0 4.7 1.2 1 0 0 1 1 1 0 GWT1 Claudin_3 PF06653.6 KII69618.1 - 3.3 7.3 14.3 0.87 9.2 4.1 1.9 1 1 1 2 2 2 0 Tight junction protein, Claudin-like Transmemb_17 PF09799.4 KII69618.1 - 5.6 7.3 11.3 0.55 10.5 4.0 1.9 2 0 0 2 2 2 0 Predicted membrane protein KH_1 PF00013.24 KII69619.1 - 1.1e-06 28.1 0.7 2.5e-06 27.0 0.5 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KII69619.1 - 1.4e-06 27.8 1.4 3.6e-06 26.5 1.0 1.7 1 0 0 1 1 1 1 KH domain WD40 PF00400.27 KII69620.1 - 8.2e-34 114.2 9.8 6.6e-08 32.1 0.0 5.7 6 0 0 6 6 6 5 WD domain, G-beta repeat DUF4002 PF13164.1 KII69620.1 - 0.046 13.6 0.8 0.18 11.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4002) DUF1611 PF07755.6 KII69620.1 - 0.14 10.8 0.0 2.1 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1611) Dimer_Tnp_hAT PF05699.9 KII69621.1 - 5.9e-07 29.0 0.1 7.4e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Gelsolin PF00626.17 KII69622.1 - 2.7e-07 30.1 0.0 3.7e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Gelsolin repeat WD40 PF00400.27 KII69623.1 - 6.7e-41 136.7 25.9 7.3e-10 38.3 0.1 10.4 11 0 0 11 11 11 7 WD domain, G-beta repeat eIF2A PF08662.6 KII69623.1 - 1.9e-08 34.2 1.1 0.0088 15.7 0.0 5.1 4 2 1 5 5 5 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KII69623.1 - 0.0069 14.5 0.1 1 7.4 0.0 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 HRM PF02793.17 KII69624.1 - 1.6e-08 34.4 0.6 2.5e-08 33.8 0.4 1.3 1 0 0 1 1 1 1 Hormone receptor domain Syntaxin PF00804.20 KII69624.1 - 0.057 13.5 0.1 0.097 12.8 0.1 1.3 1 0 0 1 1 1 0 Syntaxin PAH PF02671.16 KII69625.1 - 2.1e-09 36.8 0.1 3.8e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Paired amphipathic helix repeat Sin3_corepress PF08295.7 KII69626.1 - 6.3e-20 70.8 0.0 1.7e-19 69.4 0.0 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor HHH_7 PF14635.1 KII69626.1 - 0.037 14.1 0.0 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif DDE_Tnp_IS1595 PF12762.2 KII69627.1 - 0.0087 15.9 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain ELO PF01151.13 KII69628.1 - 1.2e-48 165.5 27.2 1.6e-48 165.2 18.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CCSMST1 PF15013.1 KII69628.1 - 0.042 13.7 2.6 0.042 13.7 1.8 2.2 2 1 0 2 2 2 0 CCSMST1 family DDE_3 PF13358.1 KII69630.1 - 1e-06 28.5 0.0 1.9e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Sarcoglycan_2 PF05510.8 KII69631.1 - 0.0076 14.5 0.2 0.0096 14.2 0.1 1.2 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon SIT PF15330.1 KII69631.1 - 0.1 12.7 0.1 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT TatC PF00902.13 KII69632.1 - 0.02 14.2 0.4 0.024 14.0 0.3 1.3 1 1 0 1 1 1 0 Sec-independent protein translocase protein (TatC) DDE_3 PF13358.1 KII69638.1 - 5.1e-05 23.0 0.2 5.7e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2310 PF10071.4 KII69639.1 - 0.0014 17.6 0.1 0.0016 17.4 0.1 1.0 1 0 0 1 1 1 1 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) Vps39_1 PF10366.4 KII69640.1 - 6.6e-07 29.3 0.1 1.7e-06 28.0 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 1 TaqI_C PF12950.2 KII69641.1 - 0.092 12.4 0.2 0.1 12.3 0.1 1.1 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain KxDL PF10241.4 KII69642.1 - 0.0028 17.4 2.0 0.0038 17.0 1.4 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein Erp_C PF06780.6 KII69642.1 - 0.0068 16.2 0.8 0.0073 16.1 0.5 1.1 1 0 0 1 1 1 1 Erp protein C-terminus Transposase_22 PF02994.9 KII69642.1 - 0.023 13.2 2.2 0.025 13.0 1.5 1.0 1 0 0 1 1 1 0 L1 transposable element Herpes_IE2_3 PF03361.9 KII69642.1 - 0.034 13.4 0.1 0.044 13.0 0.1 1.3 1 1 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 Snapin_Pallidin PF14712.1 KII69642.1 - 0.064 13.5 3.0 0.084 13.1 2.1 1.2 1 0 0 1 1 1 0 Snapin/Pallidin PEP-utilisers_N PF05524.8 KII69642.1 - 0.14 11.9 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF4200 PF13863.1 KII69642.1 - 0.18 11.7 6.0 0.97 9.3 4.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) T-box PF00907.17 KII69643.1 - 2.1e-39 134.8 0.2 3.2e-39 134.3 0.1 1.2 1 0 0 1 1 1 1 T-box DUF659 PF04937.10 KII69644.1 - 0.091 12.2 0.1 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) ERCC4 PF02732.10 KII69646.1 - 7.6e-22 77.6 0.1 7.2e-21 74.4 0.0 2.2 2 0 0 2 2 2 1 ERCC4 domain rve PF00665.21 KII69647.1 - 3e-07 30.5 0.0 5.7e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69647.1 - 2.4e-05 23.7 0.0 4.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain AT_hook PF02178.14 KII69647.1 - 3.4 7.6 8.9 7.5 6.5 6.1 1.5 1 0 0 1 1 1 0 AT hook motif Rad10 PF03834.9 KII69649.1 - 2.2e-12 46.4 0.0 5.4e-12 45.2 0.0 1.7 1 1 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) SNF2_N PF00176.18 KII69650.1 - 8.5e-60 202.0 1.1 1.6e-59 201.1 0.7 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 KII69650.1 - 1.3e-05 24.8 0.1 2.6e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Pro_isomerase PF00160.16 KII69652.1 - 2.8e-08 34.1 0.0 7.2e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cyc-maltodext_C PF10438.4 KII69652.1 - 0.012 15.6 0.9 0.029 14.3 0.6 1.6 1 0 0 1 1 1 0 Cyclo-malto-dextrinase C-terminal domain DUF565 PF04483.7 KII69652.1 - 0.58 10.3 2.2 12 6.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF565) DUF914 PF06027.7 KII69653.1 - 7.9e-34 116.9 21.9 1e-33 116.6 15.2 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EmrE PF13536.1 KII69653.1 - 1.8e-06 28.1 5.2 1.8e-06 28.1 3.6 3.1 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 KII69653.1 - 2.9e-06 27.3 31.8 3.5e-06 27.0 6.8 2.3 2 0 0 2 2 2 2 EamA-like transporter family Sec20 PF03908.8 KII69653.1 - 0.053 13.2 0.2 0.22 11.2 0.0 2.1 2 0 0 2 2 2 0 Sec20 Brucella_OMP2 PF05244.6 KII69654.1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.1 1 0 0 1 1 1 0 Brucella outer membrane protein 2 Ank_2 PF12796.2 KII69655.1 - 1.4e-20 73.4 0.0 3e-12 46.6 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KII69655.1 - 5.9e-19 66.8 2.8 0.0028 17.3 0.0 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.1 KII69655.1 - 8.2e-19 65.8 2.2 0.0077 16.3 0.0 5.9 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.1 KII69655.1 - 1.6e-18 66.6 0.5 1.3e-05 25.5 0.0 4.6 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII69655.1 - 1.7e-16 59.8 0.0 0.00016 21.7 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Pkinase PF00069.20 KII69656.1 - 5.1e-28 97.9 0.1 9.9e-28 96.9 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII69656.1 - 2.5e-20 72.6 0.0 4e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PTEN_C2 PF10409.4 KII69656.1 - 3e-09 36.7 0.4 9e-09 35.1 0.2 1.9 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DnaJ PF00226.26 KII69656.1 - 9.7e-06 25.2 0.0 4.1e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 DnaJ domain Thioredoxin PF00085.15 KII69658.1 - 4.8e-12 45.4 0.4 6.1e-12 45.1 0.3 1.0 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 KII69658.1 - 0.003 17.2 0.1 0.0033 17.0 0.1 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_3 PF13192.1 KII69658.1 - 0.0087 15.8 0.2 0.01 15.6 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_8 PF13905.1 KII69658.1 - 0.032 14.3 0.2 0.041 14.0 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin-like Salp15 PF12115.3 KII69658.1 - 0.033 14.4 0.2 0.042 14.0 0.1 1.2 1 0 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Thioredoxin_2 PF13098.1 KII69658.1 - 0.043 14.0 1.5 0.053 13.7 1.0 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain Redoxin PF08534.5 KII69658.1 - 0.047 13.2 0.1 0.05 13.1 0.0 1.1 1 0 0 1 1 1 0 Redoxin Thioredoxin PF00085.15 KII69659.1 - 9.7e-11 41.2 0.0 1.2e-10 41.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 KII69659.1 - 3.2e-05 23.9 0.0 4.3e-05 23.5 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KII69659.1 - 4e-05 23.7 0.2 0.00038 20.6 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 KII69659.1 - 4.7e-05 23.0 0.1 0.0001 21.9 0.1 1.6 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.1 KII69659.1 - 0.0016 18.0 0.1 0.0017 17.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin KaiB PF07689.7 KII69659.1 - 0.005 16.2 0.0 0.0064 15.9 0.0 1.3 1 0 0 1 1 1 1 KaiB domain Redoxin PF08534.5 KII69659.1 - 0.0058 16.1 0.0 0.007 15.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin HNH_5 PF14279.1 KII69660.1 - 0.013 15.5 0.2 0.018 15.0 0.2 1.3 1 0 0 1 1 1 0 HNH endonuclease DUF383 PF04063.9 KII69662.1 - 0.11 11.9 0.1 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF383) TRAP-gamma PF07074.7 KII69666.1 - 2.4e-18 66.2 6.3 3.9e-18 65.5 4.3 1.3 1 1 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) 7TM_GPCR_Srt PF10321.4 KII69666.1 - 0.51 9.0 11.6 0.046 12.4 3.5 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srt PNGaseA PF12222.3 KII69667.1 - 0.086 11.6 0.0 0.087 11.6 0.0 1.0 1 0 0 1 1 1 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Synaptobrevin PF00957.16 KII69668.1 - 5.3e-20 70.8 0.0 6.4e-20 70.5 0.0 1.1 1 0 0 1 1 1 1 Synaptobrevin Sec20 PF03908.8 KII69668.1 - 0.16 11.6 1.3 0.26 10.9 0.9 1.5 1 1 0 1 1 1 0 Sec20 DUF1394 PF07159.7 KII69669.1 - 7.4e-15 54.8 0.0 9.9e-15 54.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) HAP1_N PF04849.8 KII69669.1 - 0.019 13.8 0.4 0.072 12.0 0.3 1.7 1 1 0 1 1 1 0 HAP1 N-terminal conserved region PA28_beta PF02252.13 KII69669.1 - 0.077 12.4 0.0 0.19 11.1 0.0 1.6 1 1 0 1 1 1 0 Proteasome activator pa28 beta subunit Pox_MCEL PF03291.11 KII69671.1 - 2.6e-57 194.1 2.7 3.3e-57 193.8 1.9 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.1 KII69671.1 - 1.5e-05 25.2 0.1 2.9e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KII69671.1 - 3.2e-05 24.4 0.0 5.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII69671.1 - 6.2e-05 23.4 0.0 0.00011 22.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII69671.1 - 7.5e-05 22.3 0.0 0.00028 20.5 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KII69671.1 - 0.00043 20.0 0.0 0.0012 18.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KII69671.1 - 0.0018 17.6 0.0 0.0039 16.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain NIF3 PF01784.13 KII69671.1 - 0.0024 17.5 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BACK PF07707.10 KII69671.1 - 0.033 14.0 0.1 0.14 11.9 0.1 2.1 1 0 0 1 1 1 0 BTB And C-terminal Kelch Methyltransf_15 PF09445.5 KII69671.1 - 0.053 13.0 0.0 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 KII69671.1 - 0.11 12.5 0.0 0.53 10.3 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain AviRa PF11599.3 KII69671.1 - 0.16 10.9 0.0 0.31 10.0 0.0 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa MULE PF10551.4 KII69672.1 - 0.00015 21.9 0.0 0.00046 20.2 0.0 1.8 1 0 0 1 1 1 1 MULE transposase domain Ribosomal_S5_C PF03719.10 KII69675.1 - 1.2e-13 50.1 0.0 1.9e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Aph-1 PF06105.7 KII69678.1 - 3e-21 75.7 20.6 4.1e-21 75.3 14.3 1.0 1 0 0 1 1 1 1 Aph-1 protein DUF2324 PF10086.4 KII69678.1 - 0.092 11.9 4.2 0.27 10.4 1.1 2.3 2 0 0 2 2 2 0 Putative membrane peptidase family (DUF2324) MscL PF01741.13 KII69678.1 - 9.3 6.4 12.7 17 5.5 0.2 3.2 2 1 1 3 3 3 0 Large-conductance mechanosensitive channel, MscL GTP_EFTU PF00009.22 KII69679.1 - 5e-46 156.4 0.0 7.8e-46 155.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 KII69679.1 - 2.2e-09 37.3 0.5 1.4e-08 34.7 0.0 2.5 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.18 KII69679.1 - 0.00011 22.1 0.0 0.00034 20.5 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 KII69679.1 - 0.00027 19.7 0.3 0.00049 18.8 0.2 1.4 1 0 0 1 1 1 1 G-protein alpha subunit Glyco_hydro_3_C PF01915.17 KII69679.1 - 0.082 12.4 0.0 0.25 10.8 0.0 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain G-alpha PF00503.15 KII69680.1 - 2.3e-25 89.1 6.4 2.5e-25 89.0 4.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KII69680.1 - 0.0021 17.3 0.5 0.0037 16.5 0.3 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family CBM_14 PF01607.19 KII69681.1 - 6.8e-07 29.1 7.2 6.8e-07 29.1 5.0 1.7 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain PA14 PF07691.7 KII69681.1 - 0.0031 17.1 0.0 0.0057 16.3 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Hyd_WA PF06462.7 KII69682.1 - 5.2e-14 51.5 3.3 5.3e-05 22.7 0.0 4.4 4 0 0 4 4 4 3 Propeller CAP PF00188.21 KII69682.1 - 1.4e-13 51.3 4.0 6.3e-13 49.3 2.7 2.2 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Ribosomal_S6e PF01092.14 KII69684.1 - 7.5e-23 80.5 0.4 1.7e-22 79.3 0.3 1.6 1 0 0 1 1 1 1 Ribosomal protein S6e DUF3232 PF11554.3 KII69684.1 - 0.029 14.2 1.1 0.91 9.4 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3232) MULE PF10551.4 KII69685.1 - 1.4e-06 28.3 1.7 2.4e-06 27.6 0.4 1.9 2 0 0 2 2 2 1 MULE transposase domain Transposase_mut PF00872.13 KII69685.1 - 0.12 10.8 0.8 0.18 10.3 0.6 1.1 1 0 0 1 1 1 0 Transposase, Mutator family FLYWCH PF04500.11 KII69686.1 - 6.3e-11 42.0 3.3 9.9e-11 41.3 2.3 1.4 1 1 0 1 1 1 1 FLYWCH zinc finger domain RasGAP PF00616.14 KII69686.1 - 0.015 15.0 0.1 0.015 14.9 0.1 1.1 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase DUF2611 PF11022.3 KII69686.1 - 0.081 13.0 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2611) zf-GRF PF06839.7 KII69686.1 - 0.52 10.2 3.8 0.43 10.5 1.3 1.8 2 0 0 2 2 2 0 GRF zinc finger Zn_ribbon_recom PF13408.1 KII69686.1 - 3.8 7.8 7.8 34 4.8 5.4 2.2 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain HAD PF12710.2 KII69687.1 - 6.2e-15 55.8 0.3 1.4e-14 54.7 0.2 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII69687.1 - 5.7e-12 45.4 0.0 5.7e-11 42.2 0.0 2.4 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 KII69687.1 - 3.5e-10 40.6 0.1 4.9e-09 36.9 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KII69687.1 - 0.044 13.3 7.7 0.012 15.1 2.8 1.9 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 KII69688.1 - 1.8e-08 33.7 1.9 2.1e-08 33.5 0.1 1.7 1 1 0 2 2 2 1 E1-E2 ATPase zf-CGNR PF11706.3 KII69688.1 - 0.063 12.7 0.7 0.11 12.0 0.5 1.3 1 0 0 1 1 1 0 CGNR zinc finger DUF2671 PF10877.3 KII69688.1 - 0.14 11.9 0.2 0.38 10.5 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2671) MS_channel PF00924.13 KII69688.1 - 0.69 9.2 7.0 2.2 7.5 4.8 1.8 1 1 0 1 1 1 0 Mechanosensitive ion channel DUF2045 PF09741.4 KII69689.1 - 6e-22 77.9 2.9 9.9e-22 77.2 2.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) RRM_1 PF00076.17 KII69690.1 - 2.9e-35 119.7 0.6 1.9e-18 65.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII69690.1 - 1.5e-31 108.1 0.2 3.8e-17 62.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII69690.1 - 3.7e-12 45.9 0.3 7.9e-06 25.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII69690.1 - 0.011 15.5 0.2 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif OB_RNB PF08206.6 KII69690.1 - 0.1 12.1 0.1 9.5 5.8 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Rotamase_2 PF13145.1 KII69690.1 - 0.1 13.2 0.2 0.2 12.2 0.1 1.5 1 0 0 1 1 1 0 PPIC-type PPIASE domain P16-Arc PF04699.9 KII69691.1 - 1e-23 84.0 0.1 1.8e-23 83.2 0.1 1.4 1 1 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) GST_C_3 PF14497.1 KII69692.1 - 8.5e-07 29.3 0.0 1.8e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KII69692.1 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ASF1_hist_chap PF04729.8 KII69693.1 - 2.7e-60 202.4 0.7 3e-60 202.3 0.5 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone DDE_3 PF13358.1 KII69695.1 - 0.0032 17.2 0.0 0.0039 16.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease OTU PF02338.14 KII69696.1 - 0.00029 21.4 0.0 0.00087 19.8 0.0 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease DUF3733 PF12534.3 KII69696.1 - 0.00038 19.6 4.6 0.13 11.5 0.0 2.8 2 0 0 2 2 2 2 Leucine-rich repeat containing protein 8 RhoGAP PF00620.22 KII69697.1 - 3.6e-27 94.8 0.3 8.7e-27 93.6 0.1 1.7 2 0 0 2 2 2 1 RhoGAP domain CRAL_TRIO_2 PF13716.1 KII69697.1 - 3.4e-17 62.7 1.8 3.4e-17 62.7 1.2 1.9 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.15 KII69697.1 - 0.0026 17.2 1.2 0.0078 15.7 0.8 1.8 1 1 0 1 1 1 1 CRAL/TRIO domain EamA PF00892.15 KII69698.1 - 2.5 8.1 16.9 0.086 12.8 6.1 2.4 2 1 1 3 3 3 0 EamA-like transporter family RasGEF PF00617.14 KII69703.1 - 5.3e-14 52.3 0.4 1.1e-13 51.3 0.1 1.7 2 0 0 2 2 2 1 RasGEF domain DUF3541 PF12060.3 KII69703.1 - 0.075 12.3 0.3 0.13 11.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3541) RA PF00788.18 KII69703.1 - 0.083 13.3 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain ThiF PF00899.16 KII69704.1 - 4.5e-22 78.3 0.0 5.9e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.14 KII69704.1 - 0.00076 18.6 0.0 0.0008 18.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 KII69704.1 - 0.0011 19.0 0.1 0.0013 18.8 0.0 1.1 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.14 KII69704.1 - 0.027 13.5 0.6 0.033 13.2 0.4 1.1 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.11 KII69704.1 - 0.064 12.6 0.0 0.077 12.4 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 KII69704.1 - 0.098 12.0 0.1 0.12 11.7 0.1 1.1 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 KII69704.1 - 0.1 12.6 0.1 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain adh_short PF00106.20 KII69704.1 - 0.11 12.3 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase Na_Ca_ex PF01699.19 KII69707.1 - 1.3e-33 115.5 18.1 1.1e-21 76.8 8.3 2.4 2 1 0 2 2 2 2 Sodium/calcium exchanger protein gag-asp_proteas PF13975.1 KII69708.1 - 0.00033 20.4 0.1 0.00048 19.8 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII69708.1 - 0.0013 18.6 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII69708.1 - 0.0016 18.9 0.0 0.0025 18.2 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII69708.1 - 0.095 12.6 0.8 0.14 12.1 0.6 1.3 1 0 0 1 1 1 0 Zinc knuckle HEAT_2 PF13646.1 KII69709.1 - 1.1e-08 35.2 0.0 0.014 15.6 0.0 5.3 3 2 1 4 4 4 3 HEAT repeats HEAT PF02985.17 KII69709.1 - 4.6e-08 32.4 6.0 0.093 12.8 0.0 7.6 8 0 0 8 8 8 2 HEAT repeat IBN_N PF03810.14 KII69709.1 - 4.7e-08 32.8 2.1 1.1e-06 28.4 0.1 3.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_EZ PF13513.1 KII69709.1 - 6.3e-08 32.8 0.0 0.0014 19.0 0.0 5.7 7 0 0 7 7 7 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KII69709.1 - 9.3e-06 25.9 11.4 0.21 11.9 0.0 6.3 5 2 1 6 6 6 2 Vacuolar 14 Fab1-binding region RIX1 PF08167.7 KII69709.1 - 0.00014 21.5 6.8 6.1 6.5 0.0 5.7 4 2 1 5 5 5 3 rRNA processing/ribosome biogenesis Helicase_C PF00271.26 KII69710.1 - 1.7e-23 82.2 0.4 3.4e-23 81.3 0.3 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DNA_pol3_delta PF06144.8 KII69710.1 - 0.043 13.3 4.3 1.2 8.6 0.6 2.2 2 0 0 2 2 2 0 DNA polymerase III, delta subunit FleQ PF06490.6 KII69710.1 - 0.054 13.6 0.1 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ Baculo_LEF-11 PF06385.7 KII69714.1 - 0.042 13.9 0.6 0.13 12.3 0.1 1.7 2 0 0 2 2 2 0 Baculovirus LEF-11 protein zf-CCHC PF00098.18 KII69716.1 - 0.11 12.5 0.5 0.11 12.5 0.4 2.5 2 0 0 2 2 2 0 Zinc knuckle HLH PF00010.21 KII69718.1 - 1.8e-08 33.9 3.1 4.3e-08 32.7 1.3 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain GAT PF03127.9 KII69718.1 - 0.0023 17.8 0.8 0.0051 16.7 0.4 1.7 1 1 0 1 1 1 1 GAT domain SprT-like PF10263.4 KII69720.1 - 3.9e-39 133.8 1.3 5e-39 133.4 0.9 1.1 1 0 0 1 1 1 1 SprT-like family WLM PF08325.5 KII69720.1 - 0.0084 16.0 0.9 0.015 15.1 0.6 1.4 1 0 0 1 1 1 1 WLM domain DUF3267 PF11667.3 KII69720.1 - 0.37 11.0 1.6 7.3 6.8 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3267) AdoHcyase_NAD PF00670.16 KII69721.1 - 1.2e-36 126.0 0.2 1.4e-36 125.7 0.1 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.12 KII69721.1 - 2.5e-27 95.5 0.0 2.6e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase THF_DHG_CYH_C PF02882.14 KII69721.1 - 0.0031 16.5 0.2 0.0051 15.9 0.1 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.14 KII69721.1 - 0.0088 15.2 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Scs3p PF10261.4 KII69724.1 - 0.036 13.0 0.1 0.044 12.8 0.1 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Sp38 PF07354.7 KII69724.1 - 0.045 12.4 0.9 0.049 12.2 0.6 1.1 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Xpo1 PF08389.7 KII69724.1 - 0.34 10.8 2.8 0.84 9.5 0.3 2.0 2 0 0 2 2 2 0 Exportin 1-like protein DDE_1 PF03184.14 KII69726.1 - 5.4e-09 35.5 0.0 9.4e-09 34.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII69726.1 - 1.3e-06 28.1 0.1 2.2e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain PNMA PF14893.1 KII69727.1 - 0.055 12.4 0.0 0.065 12.2 0.0 1.1 1 0 0 1 1 1 0 PNMA zf-BED PF02892.10 KII69728.1 - 0.082 12.6 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 BED zinc finger CmcH_NodU PF02543.10 KII69729.1 - 0.011 14.8 0.1 0.012 14.7 0.1 1.2 1 0 0 1 1 1 0 Carbamoyltransferase DUF342 PF03961.8 KII69729.1 - 0.017 13.5 1.1 0.019 13.3 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) BLOC1_2 PF10046.4 KII69729.1 - 0.042 13.9 4.1 0.1 12.7 2.7 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4078 PF13300.1 KII69729.1 - 0.068 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4078) PNK3P PF08645.6 KII69729.1 - 0.13 11.7 1.7 0.23 10.9 0.5 1.6 1 1 1 2 2 2 0 Polynucleotide kinase 3 phosphatase MBOAT PF03062.14 KII69731.1 - 0.043 12.9 10.3 0.065 12.3 6.9 1.4 1 1 0 1 1 1 0 MBOAT, membrane-bound O-acyltransferase family Claudin_2 PF13903.1 KII69733.1 - 0.053 13.2 0.2 0.092 12.4 0.2 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DNA_pol_viral_N PF00242.12 KII69733.1 - 1.1 8.2 13.1 1.2 8.1 9.1 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Srg PF02118.16 KII69736.1 - 0.0054 16.2 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 Srg family chemoreceptor MIG-14_Wnt-bd PF06664.7 KII69736.1 - 0.011 14.6 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion PDGF_N PF04692.8 KII69736.1 - 0.4 11.2 0.1 0.4 11.2 0.1 2.2 3 1 0 3 3 3 0 Platelet-derived growth factor, N terminal region Chordopox_A13L PF05961.6 KII69743.1 - 0.18 11.7 3.1 0.82 9.6 0.0 2.6 2 1 1 3 3 3 0 Chordopoxvirus A13L protein F-box PF00646.28 KII69744.1 - 0.082 12.5 0.2 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 F-box domain DUF1301 PF06979.7 KII69746.1 - 0.031 14.4 2.9 0.1 12.7 2.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1301) SH3BGR PF04908.10 KII69748.1 - 8e-16 57.8 0.3 1.3e-15 57.1 0.2 1.3 1 1 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.19 KII69748.1 - 0.00096 19.0 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Exc PF07825.6 KII69748.1 - 0.027 14.2 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Excisionase-like protein WH2 PF02205.15 KII69749.1 - 0.00015 21.2 0.0 0.00023 20.6 0.0 1.3 1 0 0 1 1 1 1 WH2 motif DDE_Tnp_IS1595 PF12762.2 KII69751.1 - 6.7e-06 26.0 0.0 2.2e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain PRELI PF04707.9 KII69751.1 - 0.015 14.9 0.9 0.78 9.3 0.2 2.1 2 0 0 2 2 2 0 PRELI-like family Flavodoxin_5 PF12724.2 KII69751.1 - 0.087 12.8 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin domain RhoGEF PF00621.15 KII69753.1 - 9.2e-10 38.6 6.8 9.2e-10 38.6 4.7 1.7 2 0 0 2 2 2 1 RhoGEF domain Pkinase PF00069.20 KII69754.1 - 1.1e-26 93.5 0.2 1.3e-26 93.3 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII69754.1 - 2.3e-14 53.0 0.0 2.8e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KII69755.1 - 6.8e-20 71.3 0.0 7.4e-20 71.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII69755.1 - 4e-09 35.9 0.0 5.1e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII69755.1 - 0.046 12.6 0.0 0.054 12.4 0.0 1.1 1 0 0 1 1 1 0 Kinase-like DUF1610 PF07754.6 KII69758.1 - 2 8.5 5.0 1 9.5 0.5 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) Vac14_Fig4_bd PF11916.3 KII69759.1 - 3.7e-07 29.4 0.1 7.8e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding mRNA_cap_enzyme PF01331.14 KII69762.1 - 2e-48 164.6 0.0 3.4e-48 163.9 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 KII69762.1 - 1.8e-23 82.8 0.0 3.4e-23 81.9 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DSPc PF00782.15 KII69762.1 - 6e-12 45.2 0.0 1.3e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 KII69762.1 - 0.0035 17.6 0.0 0.0065 16.7 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 KII69762.1 - 0.0062 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KII69762.1 - 0.028 14.4 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate DDE_3 PF13358.1 KII69763.1 - 0.0029 17.3 0.0 0.089 12.5 0.0 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII69764.1 - 3.1e-06 27.3 0.1 5.6e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain DUF3361 PF11841.3 KII69764.1 - 0.035 13.8 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) DUF778 PF05608.7 KII69764.1 - 0.054 13.4 0.1 0.064 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF778) YobH PF13996.1 KII69764.1 - 0.099 12.5 0.1 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 YobH-like protein PLDc_2 PF13091.1 KII69766.1 - 7.2e-06 25.7 0.0 9.6e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc_3 PF13918.1 KII69766.1 - 0.00019 20.8 0.0 0.00068 19.1 0.0 1.8 2 0 0 2 2 2 1 PLD-like domain Tyr-DNA_phospho PF06087.7 KII69766.1 - 0.007 15.0 0.2 0.01 14.4 0.2 1.2 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc PF00614.17 KII69766.1 - 0.029 14.1 0.0 0.065 13.0 0.0 1.6 1 0 0 1 1 1 0 Phospholipase D Active site motif PIP49_C PF12260.3 KII69766.1 - 0.076 12.4 0.0 0.37 10.1 0.0 1.9 2 0 0 2 2 2 0 Protein-kinase domain of FAM69 PLDc_2 PF13091.1 KII69767.1 - 2.3e-17 62.8 0.0 3.6e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.17 KII69767.1 - 8.1e-05 22.2 0.1 0.00019 21.0 0.1 1.6 1 0 0 1 1 1 1 Phospholipase D Active site motif RhoGAP PF00620.22 KII69768.1 - 1.3e-27 96.2 0.2 2.5e-27 95.3 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.17 KII69768.1 - 1.9e-05 24.2 7.9 3.5e-05 23.4 5.5 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 KII69768.1 - 4.2e-05 23.1 5.0 8.2e-05 22.2 3.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 C1_3 PF07649.7 KII69768.1 - 0.13 12.3 3.2 0.31 11.0 2.2 1.6 1 0 0 1 1 1 0 C1-like domain PHD PF00628.24 KII69768.1 - 0.41 10.3 7.7 0.93 9.2 5.3 1.6 1 0 0 1 1 1 0 PHD-finger Myosin_head PF00063.16 KII69769.1 - 1.3e-26 92.9 4.2 1.6e-26 92.6 2.9 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Clostridium_P47 PF06597.6 KII69769.1 - 0.0053 15.3 1.0 0.0062 15.1 0.7 1.0 1 0 0 1 1 1 1 Clostridium P-47 protein DUF2963 PF11178.3 KII69769.1 - 0.36 10.3 5.0 5.6 6.4 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2963) Myosin_head PF00063.16 KII69770.1 - 3.6e-43 147.6 0.1 4.9e-43 147.1 0.1 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_19 PF13245.1 KII69770.1 - 0.00073 19.2 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 KII69770.1 - 0.0012 18.8 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain T2SE PF00437.15 KII69770.1 - 0.0016 17.3 0.0 0.0026 16.7 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 KII69770.1 - 0.0026 17.9 0.0 0.0061 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 KII69770.1 - 0.099 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Zeta_toxin PF06414.7 KII69770.1 - 0.11 11.5 0.0 0.27 10.3 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 KII69770.1 - 0.12 12.7 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Voltage_CLC PF00654.15 KII69771.1 - 9.8e-28 97.1 16.8 4.5e-14 52.2 3.6 3.0 1 1 2 3 3 3 3 Voltage gated chloride channel Oxidored_q1_C PF01010.14 KII69772.1 - 0.042 13.3 0.7 0.066 12.7 0.5 1.3 1 1 0 1 1 1 0 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus Ank_2 PF12796.2 KII69773.1 - 4.9e-14 52.4 0.0 1.1e-13 51.2 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KII69773.1 - 1e-11 44.0 0.1 3.4e-05 23.4 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 KII69773.1 - 3.2e-11 42.3 0.1 0.0012 18.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KII69773.1 - 6.4e-11 42.4 0.0 1.3e-05 25.5 0.0 2.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII69773.1 - 0.00048 20.2 0.0 0.0085 16.3 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) UBA_4 PF14555.1 KII69773.1 - 0.00066 19.1 0.0 0.0018 17.7 0.0 1.7 2 0 0 2 2 2 1 UBA-like domain DUF3879 PF12995.2 KII69773.1 - 0.055 13.0 0.0 0.06 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3879) Ank_2 PF12796.2 KII69774.1 - 1.9e-10 40.9 0.3 5.3e-10 39.4 0.2 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KII69774.1 - 7.1e-10 39.1 2.1 1e-05 25.8 0.2 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KII69774.1 - 4.2e-09 35.7 0.2 0.0032 17.2 0.0 3.5 3 1 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 KII69774.1 - 1.3e-06 28.0 1.0 0.09 13.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 KII69774.1 - 1.8e-06 27.9 0.2 0.00025 21.1 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) DUF21 PF01595.15 KII69775.1 - 3.2e-33 114.5 4.4 3.9e-33 114.2 2.0 1.8 2 0 0 2 2 2 1 Domain of unknown function DUF21 CBS PF00571.23 KII69775.1 - 1.8e-08 33.9 1.0 7.8e-05 22.3 0.0 2.9 2 1 0 2 2 2 2 CBS domain Dus PF01207.12 KII69776.1 - 0.021 13.6 0.0 0.025 13.4 0.0 1.1 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Ded_cyto PF06920.8 KII69777.1 - 4.7e-47 159.5 0.5 8e-47 158.8 0.3 1.3 1 0 0 1 1 1 1 Dedicator of cytokinesis DOCK-C2 PF14429.1 KII69778.1 - 5e-15 55.6 0.4 1.1e-14 54.4 0.3 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins PH PF00169.24 KII69779.1 - 1.6e-07 31.4 1.2 2.9e-07 30.6 0.1 2.0 2 0 0 2 2 2 1 PH domain PH_6 PF15406.1 KII69779.1 - 0.057 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3963 PF13124.1 KII69779.1 - 0.28 11.0 2.8 1.9 8.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3963) PH PF00169.24 KII69781.1 - 1.5e-06 28.3 0.2 2.4e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 KII69781.1 - 0.019 15.2 1.7 0.099 12.9 1.0 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain PH_4 PF15404.1 KII69781.1 - 0.044 13.3 0.1 0.086 12.3 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_3 PF14593.1 KII69781.1 - 0.089 12.6 0.3 0.22 11.4 0.2 1.8 1 1 0 1 1 1 0 PH domain DOCK-C2 PF14429.1 KII69782.1 - 7.5e-26 90.8 0.8 7.5e-26 90.8 0.6 1.8 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins ChuX_HutX PF06228.8 KII69782.1 - 0.0068 15.7 0.4 0.015 14.7 0.2 1.6 1 1 0 1 1 1 1 Haem utilisation ChuX/HutX Aminotran_1_2 PF00155.16 KII69784.1 - 3e-35 121.8 0.0 3.7e-35 121.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KII69784.1 - 3.5e-05 23.1 0.0 5.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Ank_2 PF12796.2 KII69785.1 - 2.5e-12 46.9 0.0 1.3e-06 28.6 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) LEM PF03020.10 KII69785.1 - 5.3e-09 35.3 0.0 9.6e-09 34.5 0.0 1.4 1 0 0 1 1 1 1 LEM domain Ank_5 PF13857.1 KII69785.1 - 9.9e-09 35.1 0.0 4.8e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII69785.1 - 5.9e-08 32.2 0.0 0.0058 16.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.25 KII69785.1 - 5.9e-08 32.1 0.0 0.00056 19.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KII69785.1 - 0.00066 20.1 0.1 0.02 15.3 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SAP PF02037.22 KII69785.1 - 0.045 13.2 0.0 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 SAP domain Racemase_4 PF13615.1 KII69786.1 - 0.11 12.7 0.3 0.14 12.4 0.2 1.2 1 0 0 1 1 1 0 Putative alanine racemase DNA_topoisoIV PF00521.15 KII69787.1 - 7.1e-118 394.1 0.1 1.9e-117 392.7 0.1 1.8 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 KII69787.1 - 6.4e-32 110.1 1.0 2e-31 108.5 0.7 1.8 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 KII69787.1 - 6.4e-13 48.5 0.0 3.7e-12 46.0 0.0 2.4 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.21 KII69787.1 - 1.2e-09 37.8 0.0 1.1e-08 34.8 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 7tm_1 PF00001.16 KII69788.1 - 4.5e-15 55.4 16.1 4.5e-15 55.4 11.2 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SNAP PF14938.1 KII69789.1 - 7.8e-10 38.3 1.6 1.3e-09 37.5 1.1 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII69789.1 - 0.006 16.1 2.8 0.02 14.5 1.7 2.2 1 1 0 1 1 1 1 TPR repeat DUF386 PF04074.7 KII69789.1 - 0.067 12.7 2.2 0.37 10.3 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF386) TPR_1 PF00515.23 KII69789.1 - 0.067 12.8 12.5 0.49 10.1 0.3 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII69789.1 - 0.35 10.8 9.4 3.5 7.7 0.1 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII69789.1 - 0.76 9.7 6.5 23 5.0 0.2 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII69790.1 - 0.0006 19.4 3.9 0.0006 19.4 2.7 2.2 3 1 0 3 3 3 1 TPR repeat SNAP PF14938.1 KII69790.1 - 0.0018 17.4 0.6 0.0027 16.9 0.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.23 KII69790.1 - 0.0058 16.1 7.0 1.3 8.7 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF4286 PF14114.1 KII69790.1 - 0.021 15.1 0.6 0.039 14.2 0.2 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4286) TPR_2 PF07719.12 KII69790.1 - 0.047 13.6 7.9 0.53 10.3 0.4 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII69790.1 - 0.055 13.2 5.9 5.7 6.9 0.2 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KII69790.1 - 0.13 12.2 1.0 0.33 10.9 0.7 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat NSF PF02071.15 KII69790.1 - 2.8 8.8 6.5 2.5 9.0 0.1 3.8 3 1 1 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat FLYWCH PF04500.11 KII69791.1 - 0.0036 17.1 2.3 0.011 15.5 1.1 2.0 2 0 0 2 2 2 1 FLYWCH zinc finger domain DDE_3 PF13358.1 KII69795.1 - 2.2e-22 79.3 0.1 1.1e-14 54.3 0.1 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease rve PF00665.21 KII69795.1 - 0.0042 17.1 0.0 0.0052 16.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DDE_1 PF03184.14 KII69795.1 - 0.012 14.7 0.0 0.059 12.4 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease DUF3287 PF11690.3 KII69797.1 - 0.02 14.9 1.5 0.065 13.3 1.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) T2SM PF04612.7 KII69799.1 - 0.08 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M INTS5_C PF14838.1 KII69799.1 - 0.14 10.4 0.9 0.25 9.6 0.0 1.7 2 0 0 2 2 2 0 Integrator complex subunit 5 C-terminus SNAP PF14938.1 KII69801.1 - 3.7e-08 32.8 1.4 4.3e-08 32.6 1.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.1 KII69801.1 - 6e-05 22.5 2.1 0.034 13.9 0.2 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat NSF PF02071.15 KII69801.1 - 0.00067 19.7 2.5 2 9.3 0.2 4.0 3 1 1 4 4 4 1 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.1 KII69801.1 - 0.016 14.9 10.1 0.039 13.7 1.3 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII69801.1 - 0.024 14.5 13.5 0.17 11.9 0.5 4.6 3 1 1 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 KII69801.1 - 0.057 13.3 5.7 2.7 7.9 0.1 2.8 1 1 2 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 KII69801.1 - 0.11 12.2 0.8 0.11 12.2 0.5 4.8 5 1 1 6 6 6 0 Tetratricopeptide repeat HSCB_C PF07743.8 KII69801.1 - 0.11 12.9 1.5 0.4 11.1 0.8 2.1 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain TPR_6 PF13174.1 KII69801.1 - 0.13 12.7 2.3 0.47 11.0 0.2 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF737 PF05300.6 KII69801.1 - 0.58 10.1 3.5 0.28 11.1 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF737) TPR_12 PF13424.1 KII69801.1 - 0.63 10.0 8.5 0.045 13.6 1.5 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII69801.1 - 2.6 7.7 11.6 4.1 7.1 3.2 3.8 2 1 2 4 4 4 0 TPR repeat DUF3287 PF11690.3 KII69802.1 - 0.019 15.0 1.1 0.042 13.9 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) Filo_VP35 PF02097.10 KII69803.1 - 0.012 14.8 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Filoviridae VP35 AAA_14 PF13173.1 KII69805.1 - 0.1 12.4 0.0 0.45 10.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain SNAP PF14938.1 KII69806.1 - 0.0058 15.8 0.1 0.01 15.0 0.1 1.4 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.1 KII69806.1 - 0.019 14.7 0.2 0.84 9.5 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Ndufs5 PF10200.4 KII69806.1 - 0.074 13.0 3.3 0.1 12.5 2.3 1.2 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF1968 PF09291.5 KII69806.1 - 0.1 12.4 0.1 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1968) EF1G PF00647.14 KII69806.1 - 0.48 10.1 3.1 0.62 9.7 1.9 1.4 1 1 0 1 1 1 0 Elongation factor 1 gamma, conserved domain TPR_8 PF13181.1 KII69806.1 - 0.83 9.5 7.6 0.68 9.8 0.5 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII69806.1 - 8.4 6.5 8.9 4.4 7.4 0.2 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DDE_3 PF13358.1 KII69808.1 - 2.6e-09 36.9 0.1 3.2e-09 36.6 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RVT_1 PF00078.22 KII69812.1 - 0.00074 18.9 0.0 0.0012 18.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3053 PF11254.3 KII69815.1 - 0.0045 16.2 0.1 0.0056 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3053) zf-AD PF07776.10 KII69815.1 - 0.2 11.6 1.5 0.3 11.1 0.5 1.8 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) SNAP PF14938.1 KII69816.1 - 1.1e-10 41.0 0.5 1.5e-10 40.6 0.4 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII69816.1 - 0.0017 18.2 0.1 0.019 14.8 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KII69816.1 - 0.031 14.0 3.7 0.35 10.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII69816.1 - 0.046 13.3 2.6 5 6.9 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 KII69816.1 - 0.1 12.7 3.0 0.39 10.8 2.1 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 CBP PF12192.3 KII69816.1 - 0.12 12.3 0.1 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 Fungal calcium binding protein TPR_11 PF13414.1 KII69816.1 - 0.14 11.8 1.1 0.42 10.3 0.6 2.0 2 1 0 2 2 2 0 TPR repeat rve PF00665.21 KII69817.1 - 1.9e-07 31.2 0.0 3.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain BTG PF07742.7 KII69817.1 - 0.023 14.2 0.0 0.029 13.8 0.0 1.1 1 0 0 1 1 1 0 BTG family DUF3546 PF12066.3 KII69817.1 - 0.053 13.5 0.0 0.1 12.6 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3546) DUF483 PF04467.7 KII69819.1 - 0.12 12.4 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF483) RVT_1 PF00078.22 KII69820.1 - 0.00023 20.6 0.2 0.1 11.9 0.1 2.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) COG2 PF06148.6 KII69825.1 - 0.069 13.0 0.5 0.11 12.3 0.4 1.4 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DDE_3 PF13358.1 KII69826.1 - 1.7e-14 53.7 0.0 5.2e-14 52.2 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII69826.1 - 1.1e-07 32.0 0.0 1.8e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII69826.1 - 1.6e-06 27.5 0.8 2.7e-06 26.8 0.2 1.7 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII69826.1 - 0.00011 22.0 0.6 0.00038 20.3 0.2 2.0 3 0 0 3 3 3 1 Helix-turn-helix domain Bot1p PF12298.3 KII69826.1 - 0.0011 18.9 0.2 0.0037 17.2 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein HTH_32 PF13565.1 KII69826.1 - 0.0053 17.5 0.0 0.032 15.0 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_Crp_2 PF13545.1 KII69826.1 - 0.011 15.4 0.0 0.13 12.0 0.0 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain DDE_1 PF03184.14 KII69826.1 - 0.017 14.2 0.1 0.26 10.3 0.0 2.2 1 1 0 2 2 2 0 DDE superfamily endonuclease BRX PF08381.6 KII69826.1 - 0.025 13.6 0.1 0.11 11.6 0.0 2.0 2 0 0 2 2 2 0 Transcription factor regulating root and shoot growth via Pin3 PAX PF00292.13 KII69826.1 - 0.093 12.4 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 'Paired box' domain PHP PF02811.14 KII69826.1 - 0.11 12.2 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 PHP domain Kunitz_BPTI PF00014.18 KII69828.1 - 3.4e-07 30.3 11.1 0.0024 18.0 5.2 2.3 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF1283 PF06932.6 KII69830.1 - 0.043 13.8 2.7 0.77 9.8 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1283) zf-C2H2_jaz PF12171.3 KII69830.1 - 3.4 7.9 7.3 1.7e+02 2.4 5.1 2.7 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 KII69831.1 - 0.012 15.3 4.4 0.025 14.3 3.1 1.5 1 0 0 1 1 1 0 BED zinc finger Cauli_AT PF03233.8 KII69831.1 - 0.075 12.7 4.3 0.067 12.9 1.3 1.9 2 0 0 2 2 2 0 Aphid transmission protein zf-BED PF02892.10 KII69833.1 - 3.5e-05 23.4 0.4 0.0001 21.9 0.3 1.8 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_jaz PF12171.3 KII69833.1 - 0.034 14.2 0.5 0.092 12.9 0.3 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-DBF PF07535.7 KII69833.1 - 1 9.0 5.1 0.34 10.6 0.7 2.2 2 0 0 2 2 2 0 DBF zinc finger tRNA-synt_His PF13393.1 KII69834.1 - 0.14 11.2 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 Histidyl-tRNA synthetase PRD PF00874.15 KII69834.1 - 0.3 11.2 3.8 0.16 12.0 1.1 1.7 2 0 0 2 2 2 0 PRD domain zf-CCHC_3 PF13917.1 KII69835.1 - 0.0031 17.2 14.1 0.097 12.4 0.9 2.4 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.18 KII69835.1 - 0.0036 17.1 2.2 0.0036 17.1 1.5 3.0 4 0 0 4 4 4 1 Zinc knuckle gag-asp_proteas PF13975.1 KII69835.1 - 0.058 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF1192 PF06698.6 KII69835.1 - 0.073 12.8 2.1 0.93 9.3 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) CENP-R PF06729.7 KII69835.1 - 0.084 12.5 0.5 0.14 11.8 0.4 1.4 1 0 0 1 1 1 0 Kinetochore component, CENP-R zf-CCHC_4 PF14392.1 KII69835.1 - 0.096 12.3 11.6 1.2 8.8 0.3 2.7 2 0 0 2 2 2 0 Zinc knuckle RVP PF00077.15 KII69835.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-BED PF02892.10 KII69837.1 - 0.0051 16.5 0.5 0.012 15.3 0.1 1.7 2 0 0 2 2 2 1 BED zinc finger DUF4541 PF15074.1 KII69837.1 - 0.2 12.2 2.0 0.44 11.1 0.7 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4541) AKAP95 PF04988.7 KII69840.1 - 0.021 14.6 0.5 0.023 14.4 0.3 1.1 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) zf-BED PF02892.10 KII69840.1 - 0.18 11.5 4.0 0.32 10.7 2.8 1.4 1 0 0 1 1 1 0 BED zinc finger Ecl1 PF12855.2 KII69840.1 - 1.3 8.4 5.6 2 7.7 3.9 1.4 1 0 0 1 1 1 0 Life-span regulatory factor EF-hand_5 PF13202.1 KII69841.1 - 1.1e-05 24.4 0.1 2.8e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KII69841.1 - 3.1e-05 22.9 1.6 0.00026 20.0 0.2 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KII69841.1 - 0.00053 20.0 0.2 0.0025 17.9 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KII69841.1 - 0.0016 18.1 0.3 0.0055 16.4 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 KII69841.1 - 0.0043 16.6 0.1 0.047 13.2 0.0 2.4 1 1 1 2 2 2 1 EF-hand domain pair IGFBP PF00219.13 KII69844.1 - 0.12 12.9 0.8 0.23 12.0 0.5 1.5 1 0 0 1 1 1 0 Insulin-like growth factor binding protein zf-BED PF02892.10 KII69845.1 - 0.08 12.7 3.9 0.24 11.1 2.7 1.9 1 1 0 1 1 1 0 BED zinc finger zf-C2H2_jaz PF12171.3 KII69845.1 - 0.096 12.8 3.0 5.7 7.2 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DDE_3 PF13358.1 KII69847.1 - 4.7e-14 52.3 0.2 9.4e-12 44.8 0.1 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease Guanylate_cyc_2 PF09778.4 KII69847.1 - 0.025 13.7 0.5 0.067 12.3 0.3 1.7 1 1 0 1 1 1 0 Guanylylate cyclase Corona_NS8 PF12093.3 KII69848.1 - 0.023 15.0 0.1 0.062 13.6 0.1 1.6 2 0 0 2 2 2 0 Coronavirus NS8 protein Apt1 PF10351.4 KII69848.1 - 0.077 11.8 6.3 0.089 11.6 4.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain LMBR1 PF04791.11 KII69848.1 - 0.1 11.1 0.4 0.11 11.0 0.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DDE_Tnp_IS1595 PF12762.2 KII69849.1 - 1.5e-22 80.0 0.0 6.9e-22 77.8 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII69851.1 - 4.7e-24 84.7 0.0 6.4e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Haemagg_act PF05860.8 KII69851.1 - 0.11 12.2 0.1 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 haemagglutination activity domain zf-BED PF02892.10 KII69852.1 - 0.1 12.3 2.9 0.24 11.1 2.0 1.6 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_jaz PF12171.3 KII69852.1 - 2.3 8.4 5.5 0.45 10.7 0.4 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DDE_Tnp_IS1595 PF12762.2 KII69853.1 - 0.0013 18.6 0.0 0.0049 16.6 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain Rhabdo_ncap PF00945.13 KII69858.1 - 0.0036 15.9 0.9 0.0044 15.6 0.6 1.2 1 1 0 1 1 1 1 Rhabdovirus nucleocapsid protein B2 PF11473.3 KII69858.1 - 0.07 12.7 0.2 7.5 6.2 0.0 2.6 1 1 2 3 3 3 0 RNA binding protein B2 MORN_2 PF07661.8 KII69859.1 - 0.22 11.6 1.5 0.73 10.0 0.2 2.3 1 1 1 2 2 2 0 MORN repeat variant HTH_23 PF13384.1 KII69860.1 - 4.7e-11 41.9 0.6 3e-08 33.0 0.1 3.1 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.1 KII69860.1 - 7.7e-11 41.7 0.3 7.3e-09 35.4 0.1 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII69860.1 - 1.6e-10 41.1 0.2 2.2e-10 40.6 0.1 1.3 1 1 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII69860.1 - 2.7e-09 37.6 0.8 1.4e-08 35.3 0.1 1.9 1 1 1 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII69860.1 - 1.4e-07 31.4 4.2 1.3e-05 25.1 0.1 2.2 2 0 0 2 2 2 2 Transposase HTH_24 PF13412.1 KII69860.1 - 9.7e-07 28.0 3.2 0.0018 17.6 0.1 2.9 2 1 0 2 2 2 2 Winged helix-turn-helix DNA-binding MerR PF00376.18 KII69860.1 - 5.2e-05 22.7 0.1 0.42 10.1 0.0 3.6 3 1 0 3 3 3 2 MerR family regulatory protein HTH_17 PF12728.2 KII69860.1 - 5.2e-05 23.4 1.3 3.4 7.9 0.0 3.7 4 0 0 4 4 3 1 Helix-turn-helix domain PAX PF00292.13 KII69860.1 - 8e-05 22.3 0.2 0.0001 22.0 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_1 PF01527.15 KII69860.1 - 9.3e-05 22.3 0.2 0.00022 21.1 0.0 1.7 2 0 0 2 2 2 1 Transposase HTH_Tnp_IS630 PF01710.11 KII69860.1 - 0.0001 21.9 5.4 0.00016 21.3 1.6 2.0 1 1 1 2 2 2 2 Transposase Rrf2 PF02082.15 KII69860.1 - 0.00014 21.9 0.1 0.00031 20.7 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulator MarR_2 PF12802.2 KII69860.1 - 0.00014 21.4 0.0 0.00035 20.1 0.0 1.7 1 0 0 1 1 1 1 MarR family Tn7_Tnp_TnsA_C PF08721.6 KII69860.1 - 0.00015 21.6 1.6 0.028 14.4 0.1 2.6 2 1 1 3 3 3 1 TnsA endonuclease C terminal MerR_1 PF13411.1 KII69860.1 - 0.00029 20.5 1.7 0.29 10.9 0.7 3.8 1 1 1 2 2 2 1 MerR HTH family regulatory protein HTH_11 PF08279.7 KII69860.1 - 0.0012 18.4 5.7 0.42 10.3 1.1 3.3 2 2 0 2 2 2 2 HTH domain HTH_Tnp_ISL3 PF13542.1 KII69860.1 - 0.0017 17.4 0.1 0.0041 16.2 0.0 1.7 2 0 0 2 2 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_27 PF13463.1 KII69860.1 - 0.0022 18.2 0.4 0.0087 16.3 0.1 2.1 2 1 0 2 2 2 1 Winged helix DNA-binding domain CENP-B_N PF04218.8 KII69860.1 - 0.0034 16.7 1.5 0.0089 15.4 0.1 2.4 2 1 1 3 3 3 1 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.1 KII69860.1 - 0.0035 16.8 4.1 0.084 12.4 0.1 3.3 4 0 0 4 4 3 1 Helix-turn-helix domain HHH_4 PF14490.1 KII69860.1 - 0.0075 16.0 0.4 0.54 10.0 0.3 2.3 1 1 0 1 1 1 1 Helix-hairpin-helix containing domain HTH_10 PF04967.7 KII69860.1 - 0.012 15.1 1.0 1.8 8.2 0.0 3.2 3 1 1 4 4 3 0 HTH DNA binding domain HTH_20 PF12840.2 KII69860.1 - 0.012 15.3 0.0 0.57 10.0 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain FeoC PF09012.5 KII69860.1 - 0.015 15.0 0.5 0.39 10.4 0.0 2.5 2 1 1 3 3 3 0 FeoC like transcriptional regulator Fe_dep_repress PF01325.14 KII69860.1 - 0.03 14.2 0.6 0.17 11.8 0.1 2.4 2 1 0 3 3 2 0 Iron dependent repressor, N-terminal DNA binding domain NUMOD1 PF07453.8 KII69860.1 - 0.035 13.9 3.0 0.72 9.7 0.0 3.5 4 1 0 4 4 4 0 NUMOD1 domain HTH_18 PF12833.2 KII69860.1 - 0.04 14.0 0.1 0.98 9.5 0.0 2.8 2 2 1 3 3 3 0 Helix-turn-helix domain HTH_psq PF05225.11 KII69860.1 - 0.05 13.1 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_5 PF01022.15 KII69860.1 - 0.051 13.2 0.3 0.7 9.5 0.0 2.4 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family HTH_3 PF01381.17 KII69860.1 - 0.055 13.3 1.2 1 9.2 0.1 3.0 2 2 2 4 4 4 0 Helix-turn-helix TFIIE_alpha PF02002.12 KII69860.1 - 0.056 12.9 2.0 0.1 12.0 1.4 1.6 1 1 0 1 1 1 0 TFIIE alpha subunit LacI PF00356.16 KII69860.1 - 0.074 12.6 4.0 4.7 6.9 1.0 3.4 4 0 0 4 4 4 0 Bacterial regulatory proteins, lacI family HTH_36 PF13730.1 KII69860.1 - 0.083 13.0 1.0 51 4.1 0.0 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain TrmB PF01978.14 KII69860.1 - 0.14 11.9 0.7 1.1 9.0 0.1 2.4 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_DeoR PF08220.7 KII69860.1 - 0.16 11.5 0.6 11 5.6 0.0 2.5 2 1 0 2 2 2 0 DeoR-like helix-turn-helix domain E1_DerP2_DerF2 PF02221.10 KII69861.1 - 3.9e-08 33.6 1.2 5.3e-08 33.2 0.8 1.2 1 0 0 1 1 1 1 ML domain rve PF00665.21 KII69863.1 - 5.7e-23 81.3 0.0 8.4e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69863.1 - 6.9e-06 25.4 0.0 1.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII69863.1 - 0.031 14.0 0.0 0.072 12.8 0.0 1.6 2 0 0 2 2 2 0 DDE superfamily endonuclease RVP PF00077.15 KII69864.1 - 1.2e-08 34.7 0.0 3.5e-08 33.2 0.0 1.7 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII69864.1 - 5.9e-07 29.8 0.0 1.3e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 KII69864.1 - 1.2e-06 28.4 0.0 2.1e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII69864.1 - 1.9e-06 27.4 0.1 8.3e-06 25.3 0.1 1.9 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII69864.1 - 0.00011 21.9 0.0 0.00024 20.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Peptidase_A3 PF02160.10 KII69864.1 - 0.022 14.3 0.5 0.054 13.0 0.0 1.9 2 0 0 2 2 2 0 Cauliflower mosaic virus peptidase (A3) FYVE_2 PF02318.11 KII69864.1 - 0.022 14.6 0.3 0.051 13.4 0.1 1.7 2 0 0 2 2 2 0 FYVE-type zinc finger zf-CCHC PF00098.18 KII69864.1 - 0.076 12.9 5.8 0.16 11.9 4.0 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.1 KII69864.1 - 0.13 11.9 4.8 0.34 10.6 3.3 1.7 1 0 0 1 1 1 0 Zinc knuckle Baculo_E25 PF05274.6 KII69865.1 - 0.052 13.1 0.0 0.075 12.6 0.0 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein E25 Root_cap PF06830.6 KII69868.1 - 0.0022 17.7 0.3 1.8 8.4 0.0 2.9 3 0 0 3 3 3 2 Root cap 2OG-FeII_Oxy_3 PF13640.1 KII69868.1 - 0.025 15.0 0.9 27 5.3 0.0 2.9 1 1 2 3 3 3 0 2OG-Fe(II) oxygenase superfamily HCV_env PF01539.12 KII69868.1 - 0.3 10.5 6.7 0.76 9.2 0.9 2.1 1 1 1 2 2 2 0 Hepatitis C virus envelope glycoprotein E1 Cu_bind_like PF02298.12 KII69868.1 - 0.3 10.9 3.4 17 5.3 0.1 2.9 1 1 2 3 3 3 0 Plastocyanin-like domain TAP35_44 PF07265.6 KII69870.1 - 0.3 10.8 4.6 3.9 7.2 0.8 3.3 1 1 2 3 3 3 0 Tapetum specific protein TAP35/TAP44 Rifin_STEVOR PF02009.11 KII69871.1 - 0.00067 19.3 0.1 0.00077 19.1 0.1 1.1 1 0 0 1 1 1 1 Rifin/stevor family DUF912 PF06024.7 KII69871.1 - 0.0029 17.6 0.2 0.004 17.1 0.1 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Herpes_gE PF02480.11 KII69871.1 - 0.012 13.9 0.2 0.015 13.6 0.1 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DAG1 PF05454.6 KII69871.1 - 0.015 14.5 0.1 0.015 14.5 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF1616 PF07760.6 KII69871.1 - 0.016 14.3 0.1 0.019 14.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) zf-LITAF-like PF10601.4 KII69871.1 - 0.025 14.4 1.4 0.046 13.5 1.0 1.5 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain DUF3481 PF11980.3 KII69871.1 - 0.026 14.3 0.7 0.057 13.2 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3481) CD20 PF04103.10 KII69871.1 - 0.035 14.0 0.1 0.045 13.6 0.1 1.4 1 0 0 1 1 1 0 CD20-like family TMEM154 PF15102.1 KII69871.1 - 0.037 13.7 1.0 0.057 13.1 0.7 1.3 1 1 0 1 1 1 0 TMEM154 protein family DUF3377 PF11857.3 KII69871.1 - 0.042 13.4 0.6 0.059 12.9 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF4448 PF14610.1 KII69871.1 - 0.051 13.0 0.1 0.061 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Shisa PF13908.1 KII69871.1 - 0.058 13.5 1.1 0.072 13.2 0.8 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4366 PF14283.1 KII69871.1 - 0.06 12.7 0.0 0.06 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) LRRC37AB_C PF14914.1 KII69871.1 - 0.1 12.0 0.3 0.12 11.8 0.2 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF872 PF05915.7 KII69871.1 - 0.11 12.3 0.3 0.17 11.7 0.1 1.4 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) NADH_dehy_S2_C PF06444.6 KII69871.1 - 2.6 8.4 5.1 0.41 11.0 0.9 1.6 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 C-terminus SKG6 PF08693.5 KII69871.1 - 6.9 6.0 8.1 3.9 6.8 4.4 1.6 1 1 0 1 1 1 0 Transmembrane alpha-helix domain EF-hand_like PF09279.6 KII69872.1 - 0.0095 15.9 0.5 0.02 14.9 0.3 1.5 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like zf-CCHC PF00098.18 KII69873.1 - 7.5e-07 28.7 11.8 1.5e-05 24.6 2.3 2.5 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.15 KII69873.1 - 3.6e-05 23.6 0.1 8.7e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_4 PF14392.1 KII69873.1 - 0.022 14.4 9.4 0.082 12.5 1.1 2.6 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.9 KII69873.1 - 0.11 12.4 0.0 0.32 10.8 0.0 1.9 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_3 PF13917.1 KII69873.1 - 4.1 7.2 8.6 1.5 8.6 0.4 2.6 1 1 1 2 2 2 0 Zinc knuckle Actin PF00022.14 KII69874.1 - 1.2e-161 537.5 0.0 1.4e-161 537.3 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 KII69874.1 - 0.083 13.3 0.0 0.22 11.9 0.0 1.7 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) CPSF_A PF03178.10 KII69875.1 - 2.8e-80 269.8 0.0 3.1e-77 259.8 0.0 2.5 2 0 0 2 2 2 2 CPSF A subunit region MMS1_N PF10433.4 KII69875.1 - 8e-75 251.8 0.0 9.8e-73 244.9 0.0 2.2 1 1 1 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term DDE_Tnp_IS1595 PF12762.2 KII69878.1 - 0.0011 18.8 0.1 0.0024 17.7 0.0 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain zf-Sec23_Sec24 PF04810.10 KII69880.1 - 0.014 14.9 0.3 0.033 13.7 0.2 1.7 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger NSs PF11073.3 KII69881.1 - 0.061 12.5 0.0 0.079 12.2 0.0 1.1 1 0 0 1 1 1 0 Rift valley fever virus non structural protein (NSs) like HTH_25 PF13413.1 KII69881.1 - 0.08 12.5 0.2 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain rve_3 PF13683.1 KII69882.1 - 7.1e-07 28.6 0.9 1.3e-06 27.8 0.6 1.4 1 0 0 1 1 1 1 Integrase core domain rve PF00665.21 KII69882.1 - 9.7e-07 28.9 0.4 0.00026 21.1 0.0 2.4 1 1 1 2 2 2 2 Integrase core domain EGF PF00008.22 KII69885.1 - 0.0013 18.6 1.8 0.0013 18.6 1.2 3.5 3 2 0 3 3 3 1 EGF-like domain Imm36 PF15597.1 KII69885.1 - 0.092 12.9 0.4 0.22 11.6 0.1 1.7 2 0 0 2 2 2 0 Immunity protein 36 DSL PF01414.14 KII69885.1 - 0.25 11.3 14.3 0.6 10.1 9.9 1.7 1 0 0 1 1 1 0 Delta serrate ligand hEGF PF12661.2 KII69885.1 - 1 9.5 11.0 0.18 11.9 1.1 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF Laminin_EGF PF00053.19 KII69885.1 - 8.9 6.3 20.2 31 4.6 5.8 2.6 1 1 1 2 2 2 0 Laminin EGF-like (Domains III and V) DDE_Tnp_IS1595 PF12762.2 KII69888.1 - 1.4e-09 37.9 0.0 1.7e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain Cystatin PF00031.16 KII69890.1 - 0.011 15.8 0.0 0.044 13.9 0.0 1.9 1 1 0 1 1 1 0 Cystatin domain SnoaL PF07366.7 KII69890.1 - 0.049 13.2 0.0 0.06 12.9 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase RVP PF00077.15 KII69892.1 - 9e-06 25.5 0.0 2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII69892.1 - 0.063 13.1 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease AT_hook PF02178.14 KII69892.1 - 8.1 6.4 9.5 0.3 10.9 1.0 2.5 2 0 0 2 2 2 0 AT hook motif SIS PF01380.17 KII69894.1 - 9.4e-39 132.0 0.2 5.9e-25 87.3 0.0 2.2 2 0 0 2 2 2 2 SIS domain SIS_2 PF13580.1 KII69894.1 - 0.0006 19.5 0.0 0.0023 17.6 0.0 1.9 2 0 0 2 2 2 1 SIS domain Galactosyl_T PF01762.16 KII69896.1 - 1.2e-28 100.0 1.2 2.2e-28 99.2 0.9 1.4 1 0 0 1 1 1 1 Galactosyltransferase Glyco_tranf_2_3 PF13641.1 KII69896.1 - 0.0057 16.4 0.0 0.0087 15.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 KII69896.1 - 0.11 11.7 0.0 0.27 10.5 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferase family 21 DUF4371 PF14291.1 KII69897.1 - 3.6e-07 29.9 0.0 4.9e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF4371 PF14291.1 KII69898.1 - 0.022 14.3 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) Cystatin PF00031.16 KII69899.1 - 0.11 12.6 0.0 0.14 12.3 0.0 1.4 1 1 0 1 1 1 0 Cystatin domain TMPIT PF07851.8 KII69899.1 - 0.12 11.4 0.0 0.13 11.3 0.0 1.0 1 0 0 1 1 1 0 TMPIT-like protein Cystatin PF00031.16 KII69900.1 - 0.097 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Cystatin domain DDE_Tnp_IS1595 PF12762.2 KII69903.1 - 3.3e-16 59.4 0.1 3.5e-16 59.4 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain HA PF03457.9 KII69903.1 - 0.03 14.4 0.1 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Helicase associated domain ABC_tran PF00005.22 KII69904.1 - 9.4e-43 145.8 1.1 2.1e-21 76.6 0.0 3.3 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 KII69904.1 - 3.7e-18 66.5 8.9 2.2e-05 24.5 0.0 4.4 3 1 0 3 3 3 3 AAA domain ABC_tran_2 PF12848.2 KII69904.1 - 8.1e-16 57.6 0.2 8.1e-16 57.6 0.1 2.8 3 0 0 3 3 3 1 ABC transporter SMC_N PF02463.14 KII69904.1 - 1.5e-12 47.2 3.3 0.00028 20.1 0.0 4.7 3 1 2 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KII69904.1 - 5.2e-08 32.3 0.7 0.00071 19.0 0.2 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.7 KII69904.1 - 2.2e-05 24.1 0.3 0.026 14.1 0.0 2.9 3 0 0 3 3 2 2 NACHT domain Miro PF08477.8 KII69904.1 - 2.4e-05 24.7 0.4 0.018 15.5 0.0 3.1 3 0 0 3 3 2 1 Miro-like protein AAA_23 PF13476.1 KII69904.1 - 4.4e-05 23.9 19.6 0.011 16.0 0.2 4.3 4 1 0 4 4 4 2 AAA domain AAA_15 PF13175.1 KII69904.1 - 5.3e-05 22.4 8.4 0.13 11.2 0.8 4.4 3 2 1 4 4 4 2 AAA ATPase domain AAA_17 PF13207.1 KII69904.1 - 8e-05 23.4 0.2 1 10.1 0.0 3.5 3 0 0 3 3 3 2 AAA domain SbcCD_C PF13558.1 KII69904.1 - 9e-05 22.3 0.0 0.027 14.3 0.0 3.4 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 KII69904.1 - 0.00018 21.6 0.0 0.68 10.0 0.0 3.1 3 1 0 3 3 2 2 AAA domain T2SE PF00437.15 KII69904.1 - 0.00036 19.5 0.1 0.0039 16.1 0.0 2.5 3 0 0 3 3 3 1 Type II/IV secretion system protein DUF258 PF03193.11 KII69904.1 - 0.00079 18.6 0.1 0.21 10.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 KII69904.1 - 0.00083 18.8 0.0 0.14 11.5 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_30 PF13604.1 KII69904.1 - 0.0012 18.4 0.0 3.5 7.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain MobB PF03205.9 KII69904.1 - 0.0018 17.9 0.3 0.063 12.9 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 KII69904.1 - 0.0044 17.0 0.1 0.56 10.1 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_10 PF12846.2 KII69904.1 - 0.0045 16.4 0.1 0.086 12.2 0.1 2.5 2 0 0 2 2 2 1 AAA-like domain MMR_HSR1 PF01926.18 KII69904.1 - 0.0045 16.9 0.3 0.92 9.4 0.1 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.24 KII69904.1 - 0.0056 16.8 0.4 8.7 6.5 0.0 3.6 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 KII69904.1 - 0.0075 16.5 0.2 2 8.7 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.1 KII69904.1 - 0.018 14.4 0.0 3.1 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KII69904.1 - 0.019 14.5 0.4 6.2 6.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.7 KII69904.1 - 0.022 14.0 0.9 0.43 9.8 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein PduV-EutP PF10662.4 KII69904.1 - 0.05 13.0 0.1 8.4 5.8 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.1 KII69904.1 - 0.065 12.9 0.2 3.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain RNA_helicase PF00910.17 KII69904.1 - 0.067 13.3 0.0 5 7.3 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.10 KII69904.1 - 0.082 12.6 0.7 4.6 6.9 0.1 2.7 2 0 0 2 2 2 0 NTPase UPF0079 PF02367.12 KII69904.1 - 0.11 12.1 0.1 18 4.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 GAGA_bind PF06217.7 KII69904.1 - 0.18 11.7 1.9 0.34 10.8 0.4 1.8 2 0 0 2 2 2 0 GAGA binding protein-like family Pox_A_type_inc PF04508.7 KII69904.1 - 0.21 11.4 0.1 0.21 11.4 0.1 2.9 3 0 0 3 3 2 0 Viral A-type inclusion protein repeat DUF87 PF01935.12 KII69904.1 - 0.6 9.8 7.2 0.28 10.9 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF87 Dynamin_N PF00350.18 KII69904.1 - 7.7 6.3 9.3 0.87 9.3 0.3 3.3 4 0 0 4 4 4 0 Dynamin family DDE_3 PF13358.1 KII69905.1 - 4.9e-13 49.0 0.0 7e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.2 KII69906.1 - 0.11 12.2 0.1 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 ISXO2-like transposase domain DDE_3 PF13358.1 KII69907.1 - 0.02 14.6 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease V-ATPase_C PF03223.10 KII69907.1 - 0.021 13.7 0.3 0.03 13.2 0.2 1.2 1 0 0 1 1 1 0 V-ATPase subunit C DDE_Tnp_IS1595 PF12762.2 KII69908.1 - 1.1e-10 41.5 0.0 1.3e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Phage_tail_T PF06223.7 KII69909.1 - 0.08 13.3 0.4 0.17 12.2 0.1 1.7 2 0 0 2 2 2 0 Minor tail protein T DUF479 PF04336.7 KII69909.1 - 0.086 12.9 0.1 0.29 11.2 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF479 DUF1117 PF06547.7 KII69910.1 - 0.036 14.1 0.3 0.044 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) FBD PF08387.5 KII69915.1 - 0.1 12.0 0.1 4.9 6.6 0.0 2.4 2 1 0 2 2 2 0 FBD TerY-C PF15616.1 KII69916.1 - 0.027 14.3 0.8 0.045 13.6 0.5 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain zf-C3HC4_3 PF13920.1 KII69916.1 - 0.036 13.7 1.2 0.063 12.9 0.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DNA_ligase_ZBD PF03119.11 KII69916.1 - 0.046 13.4 0.7 0.099 12.3 0.5 1.6 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Prok-RING_4 PF14447.1 KII69916.1 - 0.051 13.1 0.6 0.13 11.8 0.4 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 KCNQC3-Ank-G_bd PF11956.3 KII69916.1 - 0.063 13.3 0.0 0.28 11.2 0.0 2.0 1 1 1 2 2 2 0 Ankyrin-G binding motif of KCNQ2-3 zinc-ribbons_6 PF07191.7 KII69916.1 - 0.065 13.0 1.6 0.16 11.8 1.1 1.6 1 1 0 1 1 1 0 zinc-ribbons DZR PF12773.2 KII69916.1 - 0.088 12.6 0.9 0.17 11.7 0.6 1.5 1 0 0 1 1 1 0 Double zinc ribbon Spt4 PF06093.8 KII69916.1 - 0.1 12.4 0.7 0.3 10.9 0.5 1.7 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger zf-RING_3 PF14369.1 KII69916.1 - 0.23 11.4 4.4 0.67 10.0 3.0 1.7 1 0 0 1 1 1 0 zinc-finger Zn-ribbon_8 PF09723.5 KII69916.1 - 0.42 10.5 2.8 1.3 9.0 2.0 1.8 1 1 0 1 1 1 0 Zinc ribbon domain zf-C2H2_2 PF12756.2 KII69916.1 - 1.2 9.3 5.4 1.8 8.6 1.7 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF4096 PF13340.1 KII69917.1 - 0.07 13.0 0.1 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative transposase of IS4/5 family (DUF4096) Retrotrans_gag PF03732.12 KII69918.1 - 1.8e-05 24.7 0.0 4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.18 KII69918.1 - 0.00036 20.3 3.4 0.00036 20.3 2.4 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.1 KII69918.1 - 0.0024 17.5 0.1 0.0052 16.4 0.1 1.6 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.15 KII69918.1 - 0.018 14.9 0.0 0.044 13.7 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII69918.1 - 0.057 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_5 PF14787.1 KII69918.1 - 0.075 12.5 2.0 0.21 11.0 1.4 1.8 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Peptidase_C1 PF00112.18 KII69919.1 - 1.3e-44 152.7 0.0 1.8e-44 152.2 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII69919.1 - 1.2e-10 41.5 3.4 2e-10 40.7 2.4 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF1497 PF07384.6 KII69920.1 - 0.05 13.7 0.0 0.089 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1497) RVT_1 PF00078.22 KII69921.1 - 0.0026 17.1 0.0 0.0029 16.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DBC1 PF14443.1 KII69921.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.4 2 0 0 2 2 2 0 DBC1 DAGK_cat PF00781.19 KII69923.1 - 0.064 12.6 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF106 PF01956.11 KII69924.1 - 2.4e-16 59.7 2.2 2.7e-16 59.5 1.6 1.2 1 0 0 1 1 1 1 Integral membrane protein DUF106 DDE_Tnp_IS1595 PF12762.2 KII69925.1 - 5.5e-22 78.2 0.0 2.3e-21 76.2 0.0 1.9 1 1 0 1 1 1 1 ISXO2-like transposase domain zf-tcix PF14952.1 KII69925.1 - 0.0077 15.5 0.7 0.0077 15.5 0.5 1.9 2 0 0 2 2 2 1 Putative treble-clef, zinc-finger, Zn-binding Inhibitor_I29 PF08246.7 KII69926.1 - 2.2e-11 43.8 5.2 3.1e-11 43.3 3.6 1.2 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.18 KII69926.1 - 1.6e-08 34.7 0.4 7.4e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 Papain family cysteine protease DUF694 PF05107.7 KII69926.1 - 0.0033 16.6 0.2 0.004 16.4 0.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF694) DUF2963 PF11178.3 KII69926.1 - 0.39 10.1 4.6 1 8.8 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) Peptidase_C1 PF00112.18 KII69927.1 - 4.6e-55 186.8 0.1 3.1e-30 105.7 0.0 2.5 2 1 1 3 3 3 2 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII69927.1 - 7.3e-11 42.1 5.2 1.2e-10 41.4 3.6 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KII69927.1 - 0.0014 17.2 0.5 0.004 15.7 0.0 1.8 2 1 0 2 2 2 1 Peptidase C1-like family DUF694 PF05107.7 KII69927.1 - 0.021 14.0 0.1 0.03 13.5 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF694) Peptidase_C1 PF00112.18 KII69928.1 - 1.7e-35 122.8 0.0 5e-35 121.3 0.0 1.7 2 1 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII69928.1 - 1.7e-12 47.4 7.9 2.7e-12 46.7 5.5 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF694 PF05107.7 KII69928.1 - 0.051 12.7 0.2 0.11 11.7 0.1 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF694) HGTP_anticodon PF03129.15 KII69929.1 - 8.6e-21 73.6 0.0 1.9e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.20 KII69929.1 - 4.2e-12 45.9 0.2 1.2e-11 44.4 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF77 PF01910.12 KII69929.1 - 0.024 14.3 0.0 0.053 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF77 DUF1978 PF09321.5 KII69930.1 - 0.022 14.2 2.8 0.026 13.9 1.8 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1978) SpoIIE PF07228.7 KII69930.1 - 0.04 13.6 0.1 0.043 13.5 0.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) DUF2216 PF10226.4 KII69930.1 - 0.26 10.7 4.4 0.32 10.4 3.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) DDE_3 PF13358.1 KII69931.1 - 3.4e-14 52.8 0.0 4.8e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease MTBP_mid PF14919.1 KII69931.1 - 0.0053 15.4 0.0 0.0061 15.2 0.0 1.0 1 0 0 1 1 1 1 MDM2-binding DDE_1 PF03184.14 KII69932.1 - 9.6e-15 54.3 0.0 1.4e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease WSC PF01822.14 KII69935.1 - 1.6e-12 47.1 6.6 1.6e-12 47.1 4.6 3.4 3 0 0 3 3 3 2 WSC domain NTS_2 PF15448.1 KII69935.1 - 0.082 13.2 2.2 0.22 11.8 0.2 2.4 2 0 0 2 2 2 0 N-terminal segments of P. falciparum erythrocyte membrane protein WD40 PF00400.27 KII69936.1 - 0.0054 16.5 9.6 0.21 11.5 0.1 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat PQQ_3 PF13570.1 KII69936.1 - 0.1 12.8 0.1 0.39 11.0 0.0 2.0 2 0 0 2 2 2 0 PQQ-like domain RNA_pol_Rpb6 PF01192.17 KII69937.1 - 1.2e-22 79.3 0.8 1.8e-22 78.7 0.5 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 DDE_1 PF03184.14 KII69938.1 - 3.4e-06 26.3 0.1 4.5e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease IU_nuc_hydro PF01156.14 KII69941.1 - 5.8e-39 134.1 0.0 6.5e-39 133.9 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Glycos_transf_2 PF00535.21 KII69942.1 - 0.11 12.2 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 SLA_LP_auto_ag PF05889.8 KII69943.1 - 3.7e-98 328.5 0.0 4.9e-98 328.1 0.0 1.1 1 0 0 1 1 1 1 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Beta_elim_lyase PF01212.16 KII69943.1 - 1.8e-05 24.0 0.0 2.3e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 KII69943.1 - 0.00015 20.8 0.0 0.00023 20.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II FLYWCH PF04500.11 KII69945.1 - 1.9e-10 40.4 0.4 4.2e-10 39.3 0.3 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain H_lectin PF09458.5 KII69945.1 - 0.078 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 H-type lectin domain Leukocidin PF07968.7 KII69945.1 - 0.084 12.5 0.0 0.099 12.2 0.0 1.1 1 0 0 1 1 1 0 Leukocidin/Hemolysin toxin family UBX PF00789.15 KII69947.1 - 2.9e-05 24.0 0.0 7e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 UBX domain Med17 PF10156.4 KII69947.1 - 0.051 11.8 1.5 0.073 11.3 0.1 1.7 1 1 0 2 2 2 0 Subunit 17 of Mediator complex YebO PF13974.1 KII69947.1 - 0.25 11.1 1.0 0.44 10.3 0.0 2.0 2 0 0 2 2 2 0 YebO-like protein RVT_1 PF00078.22 KII69951.1 - 3e-22 79.0 0.1 2.1e-21 76.2 0.0 2.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII69951.1 - 9.4e-08 31.8 0.0 2.5e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.21 KII69951.1 - 0.00034 20.7 0.0 0.0018 18.3 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain Asp_protease_2 PF13650.1 KII69951.1 - 0.0074 16.7 0.0 0.017 15.6 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_4 PF14392.1 KII69951.1 - 0.038 13.6 8.5 0.15 11.7 0.5 2.7 2 0 0 2 2 2 0 Zinc knuckle MFS_1 PF07690.11 KII69952.1 - 1.1e-33 116.4 19.2 2.4e-33 115.3 12.6 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KII69952.1 - 8.6e-13 47.6 25.2 1.3e-10 40.4 10.9 2.9 1 1 1 3 3 3 3 Sugar (and other) transporter Cauli_AT PF03233.8 KII69955.1 - 0.024 14.3 5.1 0.057 13.1 0.4 2.1 2 0 0 2 2 2 0 Aphid transmission protein Metallophos_3 PF14582.1 KII69955.1 - 0.024 13.7 0.1 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily DUF4533 PF15047.1 KII69955.1 - 0.027 13.8 1.2 0.027 13.8 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4533) Laminin_I PF06008.9 KII69955.1 - 0.54 9.5 4.5 0.71 9.1 3.2 1.1 1 0 0 1 1 1 0 Laminin Domain I Fib_alpha PF08702.5 KII69955.1 - 4 7.5 12.5 0.17 12.0 0.8 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.4 KII69955.1 - 9.7 6.3 10.3 4.7 7.4 0.7 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RHSP PF07999.6 KII69956.1 - 0.086 11.4 0.3 0.082 11.4 0.2 1.0 1 0 0 1 1 1 0 Retrotransposon hot spot protein DDE_Tnp_IS1595 PF12762.2 KII69958.1 - 1.1e-07 31.7 0.0 2.9e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain TRAP_beta PF05753.9 KII69959.1 - 5.1e-24 84.4 0.3 5.9e-24 84.2 0.2 1.0 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DDE_3 PF13358.1 KII69960.1 - 1.8e-17 63.4 0.1 2.8e-17 62.8 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII69960.1 - 0.0006 19.0 0.3 0.0007 18.8 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII69960.1 - 0.001 19.1 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain SAGA-Tad1 PF12767.2 KII69960.1 - 0.017 14.8 0.6 0.022 14.4 0.4 1.3 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit CHASE3 PF05227.8 KII69960.1 - 0.042 13.5 0.1 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 CHASE3 domain CsgE PF10627.4 KII69960.1 - 0.068 12.9 0.4 0.086 12.6 0.3 1.2 1 0 0 1 1 1 0 Curli assembly protein CsgE DUF4298 PF14131.1 KII69960.1 - 0.076 12.8 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) CactinC_cactus PF09732.4 KII69961.1 - 1.5e-41 140.8 4.6 1.5e-41 140.8 3.2 2.0 2 0 0 2 2 2 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.4 KII69961.1 - 1.1e-18 67.1 2.9 1.7e-18 66.6 2.0 1.3 1 0 0 1 1 1 1 Conserved mid region of cactin DDE_Tnp_IS1595 PF12762.2 KII69962.1 - 3.6e-11 43.1 0.0 6e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_1 PF03184.14 KII69962.1 - 2.9e-05 23.3 0.1 5e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Transposase_mut PF00872.13 KII69963.1 - 0.025 13.1 1.6 0.042 12.3 1.1 1.3 1 1 0 1 1 1 0 Transposase, Mutator family PI-PLC-X PF00388.14 KII69964.1 - 4.9e-62 207.6 0.1 1.4e-61 206.1 0.1 1.9 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.6 KII69964.1 - 1e-08 35.0 1.7 1e-08 35.0 1.2 2.1 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like PI-PLC-Y PF00387.14 KII69964.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, Y domain Spc7 PF08317.6 KII69968.1 - 0.0017 17.0 6.9 0.0047 15.6 4.8 1.7 1 1 0 1 1 1 1 Spc7 kinetochore protein Kinesin-related PF06548.6 KII69968.1 - 0.03 12.8 1.4 0.03 12.8 1.0 1.2 1 0 0 1 1 1 0 Kinesin-related DUF4200 PF13863.1 KII69968.1 - 0.042 13.8 3.6 0.087 12.7 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) TMF_TATA_bd PF12325.3 KII69968.1 - 0.058 13.1 2.6 3.2 7.5 0.0 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Flg_hook PF02120.11 KII69968.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK Phlebovirus_NSM PF07246.6 KII69968.1 - 0.77 8.8 6.3 4.5 6.3 2.7 2.0 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M YgaB PF14182.1 KII69968.1 - 0.82 9.9 10.3 0.81 9.9 3.0 2.8 1 1 2 3 3 3 0 YgaB-like protein Takusan PF04822.8 KII69968.1 - 1 9.1 5.4 1.3 8.8 1.7 2.4 2 1 0 2 2 2 0 Takusan TACC PF05010.9 KII69974.1 - 0.0076 16.0 23.2 0.031 14.0 16.1 2.1 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) DUF1664 PF07889.7 KII69974.1 - 0.35 10.6 9.3 0.58 9.9 1.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.3 KII69974.1 - 0.7 9.7 19.9 3.3 7.5 3.4 3.9 2 2 1 3 3 3 0 TATA element modulatory factor 1 DNA binding PEP-utilisers_N PF05524.8 KII69974.1 - 0.89 9.3 4.2 1.1 9.0 1.1 2.4 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal IncA PF04156.9 KII69974.1 - 2.4 7.7 16.3 6.5 6.3 7.7 2.5 1 1 1 2 2 2 0 IncA protein ING PF12998.2 KII69974.1 - 3 8.1 11.4 1.4 9.1 5.4 2.5 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding TPR_MLP1_2 PF07926.7 KII69974.1 - 4.9 6.9 18.1 1.8e+03 -1.5 12.1 2.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein bZIP_1 PF00170.16 KII69974.1 - 9.6 6.2 14.2 2.2 8.2 0.3 4.1 3 1 1 4 4 4 0 bZIP transcription factor DDE_Tnp_IS1595 PF12762.2 KII69975.1 - 5.9e-07 29.4 0.0 6.9e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF747 PF05346.6 KII69976.1 - 1.9e-08 33.7 0.3 3e-08 33.0 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family Ribosomal_S8 PF00410.14 KII69976.1 - 0.083 12.7 0.1 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein S8 P_proprotein PF01483.15 KII69977.1 - 2.2e-06 27.3 0.1 4.1e-06 26.4 0.1 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain MRP-L46 PF11788.3 KII69977.1 - 0.05 14.2 10.6 1.7 9.3 3.5 2.4 1 1 1 2 2 2 0 39S mitochondrial ribosomal protein L46 FAM183 PF14886.1 KII69977.1 - 0.75 10.3 8.6 1.8 9.1 2.6 2.3 2 0 0 2 2 2 0 FAM183A and FAM183B related Ribosomal_S11 PF00411.14 KII69978.1 - 8.7e-41 138.5 0.4 1.1e-40 138.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 HTH_33 PF13592.1 KII69979.1 - 0.00064 19.2 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix Herpes_UL52 PF03121.10 KII69982.1 - 0.035 13.8 0.2 0.035 13.8 0.2 2.3 3 0 0 3 3 3 0 Herpesviridae UL52/UL70 DNA primase rve PF00665.21 KII69983.1 - 4.4e-12 46.1 0.0 8.6e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII69983.1 - 0.00062 19.2 0.0 0.0011 18.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF2963 PF11178.3 KII69986.1 - 0.43 10.0 5.1 4.4 6.8 1.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2963) DUF507 PF04368.8 KII69987.1 - 0.091 12.3 0.2 0.14 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF507) Pup_ligase PF03136.10 KII69987.1 - 0.11 11.1 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Pup-ligase protein Patched PF02460.13 KII69989.1 - 1.3e-17 63.0 19.2 1.5e-17 62.8 13.3 1.0 1 0 0 1 1 1 1 Patched family DUF4500 PF14937.1 KII69989.1 - 0.27 11.0 4.6 0.96 9.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4500) FUSC-like PF12805.2 KII69989.1 - 0.4 9.5 7.2 0.62 8.9 5.0 1.3 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS ACR_tran PF00873.14 KII69989.1 - 1.7 5.9 10.8 2 5.7 7.5 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Patched PF02460.13 KII69990.1 - 2e-45 155.0 7.8 3.1e-45 154.4 5.4 1.4 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.3 KII69990.1 - 2.7e-39 134.0 12.9 2.7e-39 134.0 9.0 2.6 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 KII69990.1 - 2.8 6.5 11.1 5.2 5.6 7.7 1.4 1 0 0 1 1 1 0 MMPL family CTX_RstB PF07459.6 KII69991.1 - 0.036 13.9 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 CTX phage RstB protein Bac_export_3 PF01313.14 KII69991.1 - 0.21 11.2 4.4 6.8 6.4 0.8 2.3 2 0 0 2 2 2 0 Bacterial export proteins, family 3 DUF4448 PF14610.1 KII69992.1 - 0.069 12.6 0.0 0.088 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) LRR_4 PF12799.2 KII69993.1 - 6.2e-18 64.0 16.1 2.7e-07 30.0 2.0 4.6 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KII69993.1 - 1.6e-12 47.0 17.9 7.1e-06 25.6 3.1 4.1 3 1 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 KII69993.1 - 6.2e-12 43.8 17.0 0.04 13.9 0.0 8.3 8 1 0 8 8 8 4 Leucine Rich Repeat LRR_6 PF13516.1 KII69993.1 - 1.1e-07 31.1 14.8 0.11 12.6 0.1 6.8 6 1 1 7 7 7 3 Leucine Rich repeat LRR_7 PF13504.1 KII69993.1 - 1.4e-06 27.5 8.0 0.42 11.0 0.1 6.4 6 0 0 6 6 6 1 Leucine rich repeat CH PF00307.26 KII69993.1 - 3.2e-05 23.9 0.1 7e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KII69993.1 - 0.0056 16.2 0.4 0.016 14.8 0.1 1.9 2 0 0 2 2 2 1 CAMSAP CH domain MT-A70 PF05063.9 KII69994.1 - 2.1e-47 160.9 0.0 3.7e-47 160.1 0.0 1.4 1 0 0 1 1 1 1 MT-A70 DUF4448 PF14610.1 KII69995.1 - 0.082 12.3 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) HTH_Tnp_Tc5 PF03221.11 KII69996.1 - 0.0045 16.7 0.1 0.008 15.9 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 KII69996.1 - 0.054 12.6 0.2 0.21 10.7 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease XAP5 PF04921.9 KII69997.1 - 7.4e-42 143.5 5.7 2.1e-41 142.0 3.9 1.6 1 1 0 1 1 1 1 XAP5, circadian clock regulator PIN_4 PF13638.1 KII69997.1 - 0.04 14.0 0.1 0.85 9.7 0.0 2.2 2 0 0 2 2 2 0 PIN domain HTH_Tnp_Tc3_2 PF01498.13 KII69998.1 - 2.3e-06 27.5 0.0 4.4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Transposase DDE_3 PF13358.1 KII69998.1 - 4.1e-06 26.5 0.0 0.025 14.3 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_32 PF13565.1 KII69998.1 - 0.0038 17.9 0.0 0.0074 17.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain TORC_N PF12884.2 KII69999.1 - 0.28 11.7 1.9 0.41 11.1 0.1 1.9 2 0 0 2 2 2 0 Transducer of regulated CREB activity, N terminus RRM_1 PF00076.17 KII70001.1 - 5.3e-41 138.0 0.1 4e-17 61.6 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII70001.1 - 3.5e-30 103.7 0.1 2e-12 46.9 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII70001.1 - 1.5e-28 98.3 0.0 3.3e-10 39.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer PF06495.6 KII70001.1 - 0.12 12.2 24.1 0.26 11.1 16.7 1.5 1 0 0 1 1 1 0 Fruit fly transformer protein GAGA_bind PF06217.7 KII70001.1 - 0.2 11.5 5.4 0.36 10.7 3.8 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family PRP38_assoc PF12871.2 KII70001.1 - 0.63 10.6 37.9 1.2 9.6 26.3 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 PF13054.1 KII70001.1 - 0.65 9.9 3.3 2.8 7.9 2.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) Tubulin PF00091.20 KII70002.1 - 2.3e-59 200.8 0.0 2.8e-59 200.5 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.1 KII70002.1 - 0.00031 20.2 0.0 0.0005 19.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_C PF03953.12 KII70003.1 - 1.3e-15 57.5 0.4 2.2e-15 56.8 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain ATP-gua_PtransN PF02807.10 KII70003.1 - 0.072 13.2 0.1 0.17 12.0 0.0 1.7 2 0 0 2 2 2 0 ATP:guanido phosphotransferase, N-terminal domain MCM PF00493.18 KII70004.1 - 1.3e-122 408.7 0.1 2.3e-122 407.9 0.0 1.4 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 KII70004.1 - 1.2e-20 74.2 1.6 7.1e-20 71.7 0.6 2.8 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 KII70004.1 - 6.1e-07 28.8 0.1 2e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KII70004.1 - 1.9e-05 24.4 0.0 0.00011 21.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KII70004.1 - 0.00016 21.3 0.0 0.0022 17.6 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KII70004.1 - 0.011 15.2 0.0 2.5 7.5 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Ribosomal_S7e PF01251.13 KII70006.1 - 9.5e-37 126.3 1.9 1.2e-36 126.0 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S7e DDE_3 PF13358.1 KII70007.1 - 2.1e-15 56.7 0.0 3.1e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII70007.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.5 1 1 0 1 1 1 0 Integrase core domain C2 PF00168.25 KII70008.1 - 2e-39 133.2 17.7 1.9e-12 46.8 0.2 6.5 6 0 0 6 6 6 5 C2 domain FYVE_2 PF02318.11 KII70008.1 - 3.2e-14 52.8 4.2 3.2e-14 52.8 2.9 2.4 2 0 0 2 2 2 1 FYVE-type zinc finger DUF1746 PF08508.5 KII70008.1 - 0.31 10.9 0.0 0.84 9.5 0.0 1.7 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1746) MFS_1 PF07690.11 KII70010.1 - 3e-10 39.3 23.6 8.4e-07 28.0 9.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pmp3 PF01679.12 KII70010.1 - 0.052 13.2 0.8 0.052 13.2 0.5 3.0 3 1 0 3 3 3 0 Proteolipid membrane potential modulator TRAP_beta PF05753.9 KII70011.1 - 3.6e-24 84.9 0.4 4.2e-24 84.6 0.3 1.0 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) OST3_OST6 PF04756.8 KII70013.1 - 5.7e-14 51.9 5.2 9e-14 51.3 3.6 1.3 1 1 0 1 1 1 1 OST3 / OST6 family Cyto_ox_2 PF02322.10 KII70013.1 - 0.016 14.3 3.2 0.016 14.3 1.7 1.3 1 1 0 1 1 1 0 Cytochrome oxidase subunit II DUF389 PF04087.9 KII70013.1 - 0.057 13.3 2.1 2.1 8.2 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF389) NADH-u_ox-rdase PF10785.4 KII70013.1 - 0.13 12.5 1.3 0.29 11.3 0.5 1.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF1516 PF07457.6 KII70013.1 - 0.14 12.2 7.5 0.48 10.5 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) Phage_holin_1 PF04531.8 KII70013.1 - 0.46 10.5 2.3 0.38 10.8 0.2 2.0 2 1 1 3 3 3 0 Bacteriophage holin DUF805 PF05656.9 KII70013.1 - 0.49 10.2 5.3 0.23 11.2 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF805) DUF1772 PF08592.6 KII70013.1 - 0.52 10.0 4.7 3.6 7.3 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) 7TM-7TMR_HD PF07698.6 KII70013.1 - 1.4 8.3 13.2 3.6 6.9 2.8 2.3 2 1 0 2 2 2 0 7TM receptor with intracellular HD hydrolase Yip1 PF04893.12 KII70013.1 - 2.6 7.5 10.9 0.22 11.0 2.7 2.1 2 1 0 2 2 2 0 Yip1 domain DUF4149 PF13664.1 KII70013.1 - 3.9 7.5 8.3 2.8 8.0 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) DUF2976 PF11190.3 KII70013.1 - 4.7 6.7 6.6 3.2 7.3 2.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2976) MFS_1 PF07690.11 KII70015.1 - 3.2e-10 39.2 8.2 4.1e-10 38.9 5.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KII70015.1 - 0.00044 18.9 5.1 0.00044 18.9 3.5 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter UNC-93 PF05978.11 KII70015.1 - 3.2 7.2 11.4 1 8.8 4.0 2.1 1 1 0 2 2 2 0 Ion channel regulatory protein UNC-93 MFS_1 PF07690.11 KII70016.1 - 1.2e-10 40.7 12.3 2.1e-10 39.8 8.6 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily RNase_E_G PF10150.4 KII70022.1 - 0.025 13.8 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 Ribonuclease E/G family Thioredoxin_9 PF14595.1 KII70022.1 - 0.047 13.2 0.3 0.31 10.5 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin rve PF00665.21 KII70023.1 - 1.8e-07 31.2 0.0 2.7e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII70023.1 - 4.6e-05 22.7 0.0 8.3e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Cu2_monooxygen PF01082.15 KII70024.1 - 0.011 15.6 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Copper type II ascorbate-dependent monooxygenase, N-terminal domain RVT_1 PF00078.22 KII70025.1 - 2.2e-25 89.3 0.3 6.1e-25 87.8 0.1 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII70025.1 - 3.4e-24 85.2 0.0 1e-23 83.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Spuma_A9PTase PF03539.9 KII70025.1 - 3.5e-05 23.7 0.0 7.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) rve_3 PF13683.1 KII70025.1 - 0.0022 17.4 0.0 0.006 16.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII70025.1 - 0.011 15.1 0.4 0.024 14.0 0.3 1.6 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger Asp_protease_2 PF13650.1 KII70028.1 - 5e-08 33.3 0.1 1e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII70028.1 - 5.3e-07 29.3 0.0 1.8e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII70028.1 - 2.3e-05 24.2 0.3 9.4e-05 22.2 0.1 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease RVP_2 PF08284.6 KII70028.1 - 0.00046 20.1 0.5 0.0013 18.6 0.1 2.0 2 1 1 3 3 3 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII70028.1 - 0.004 17.0 10.1 0.01 15.7 2.8 2.4 2 0 0 2 2 2 1 Zinc knuckle Stc1 PF12898.2 KII70028.1 - 0.011 15.7 4.7 0.021 14.8 3.3 1.4 1 0 0 1 1 1 0 Stc1 domain Asp_protease PF09668.5 KII70028.1 - 0.044 13.3 0.1 0.08 12.5 0.0 1.5 1 1 0 1 1 1 0 Aspartyl protease zf-CCHC_3 PF13917.1 KII70028.1 - 8.3 6.2 8.2 2.3 8.0 0.3 2.3 1 1 1 2 2 2 0 Zinc knuckle MAGSP PF03082.9 KII70030.1 - 0.022 14.1 0.0 0.024 14.0 0.0 1.0 1 0 0 1 1 1 0 Male accessory gland secretory protein rve PF00665.21 KII70031.1 - 1.8e-21 76.4 0.0 4.7e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII70031.1 - 2e-07 30.3 0.2 5.1e-07 29.0 0.2 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII70031.1 - 9.4e-05 21.8 0.2 0.00031 20.1 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-met PF12874.2 KII70034.1 - 3.3e-05 23.9 1.2 5.4e-05 23.2 0.9 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KII70034.1 - 5.8e-05 23.0 0.6 0.00012 22.0 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.7 KII70034.1 - 0.00013 21.4 0.7 0.00024 20.5 0.5 1.4 1 0 0 1 1 1 1 U1 zinc finger DUF1314 PF07013.6 KII70034.1 - 0.059 12.7 0.2 0.082 12.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) HemX PF04375.9 KII70034.1 - 0.071 11.6 2.9 0.084 11.4 2.0 1.1 1 0 0 1 1 1 0 HemX Syntaxin PF00804.20 KII70034.1 - 0.32 11.1 10.2 0.66 10.1 7.1 1.5 1 0 0 1 1 1 0 Syntaxin DUF1777 PF08648.7 KII70034.1 - 0.49 10.1 9.1 0.062 13.0 3.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) LUC7 PF03194.10 KII70034.1 - 2.3 7.6 13.1 3.3 7.1 9.1 1.2 1 1 0 1 1 1 0 LUC7 N_terminus SPT16 PF08644.6 KII70034.1 - 6.7 6.5 9.7 1.9 8.3 4.6 1.6 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) DUF1599 PF07659.6 KII70034.1 - 6.9 6.8 6.3 1.9 8.5 0.4 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1599) DDE_3 PF13358.1 KII70035.1 - 3.2e-13 49.6 0.1 4.2e-13 49.2 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_5 PF13854.1 KII70037.1 - 3.7e-08 33.1 3.1 0.00057 19.7 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII70037.1 - 2e-05 24.0 11.2 0.027 14.0 2.1 2.9 2 1 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 KII70037.1 - 4.4e-05 23.4 5.9 0.0034 17.4 0.4 2.6 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII70037.1 - 6.8e-05 22.5 5.6 0.027 14.2 0.1 2.6 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII70037.1 - 0.0011 18.6 5.8 0.42 10.4 0.1 2.6 2 1 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 KII70037.1 - 0.0012 18.9 4.7 1.9 8.7 0.0 3.4 3 1 0 3 3 3 2 Galactose oxidase, central domain Claudin_3 PF06653.6 KII70038.1 - 0.00032 20.4 7.8 0.00058 19.6 5.4 1.3 1 0 0 1 1 1 1 Tight junction protein, Claudin-like Claudin_2 PF13903.1 KII70038.1 - 0.01 15.5 8.6 0.034 13.8 6.1 1.7 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction L_HGMIC_fpl PF10242.4 KII70038.1 - 0.017 15.1 5.0 0.034 14.1 3.3 1.5 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein HlyIII PF03006.15 KII70038.1 - 0.056 12.8 5.2 0.04 13.3 1.6 1.8 2 0 0 2 2 2 0 Haemolysin-III related DUF3816 PF12822.2 KII70038.1 - 0.44 10.4 9.5 0.82 9.5 6.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) DUF2207 PF09972.4 KII70038.1 - 0.45 9.0 3.9 1.3 7.5 0.6 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Clc-like PF07062.7 KII70038.1 - 0.64 9.2 6.1 9.2 5.4 3.8 2.2 1 1 0 1 1 1 0 Clc-like ABC2_membrane_3 PF12698.2 KII70038.1 - 0.91 8.4 10.9 0.41 9.6 4.8 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein Oxidored_q3 PF00499.15 KII70038.1 - 1.9 8.2 16.4 1.4 8.7 7.4 2.1 1 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 HTH_32 PF13565.1 KII70039.1 - 1.7e-05 25.4 0.1 3.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII70039.1 - 6.9e-05 22.5 1.2 9.8e-05 22.0 0.8 1.2 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc3_2 PF01498.13 KII70039.1 - 0.00011 22.1 0.8 0.00042 20.3 0.2 2.0 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.1 KII70039.1 - 0.00048 19.6 0.0 0.00099 18.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix DDE_3 PF13358.1 KII70039.1 - 0.0041 16.8 0.0 0.01 15.6 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII70039.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix Arg_repressor PF01316.16 KII70039.1 - 0.012 15.1 0.6 0.02 14.4 0.4 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_28 PF13518.1 KII70039.1 - 0.03 14.3 0.0 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.1 KII70039.1 - 0.039 13.6 0.0 0.63 9.7 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain PAX PF00292.13 KII70039.1 - 0.044 13.4 0.1 0.066 12.9 0.1 1.2 1 0 0 1 1 1 0 'Paired box' domain TAN PF11640.3 KII70041.1 - 0.14 11.8 2.0 0.26 10.9 0.6 1.8 1 1 1 2 2 2 0 Telomere-length maintenance and DNA damage repair zf-CCHC PF00098.18 KII70042.1 - 1.9e-06 27.5 4.6 3.6e-06 26.6 3.2 1.5 1 0 0 1 1 1 1 Zinc knuckle Vasohibin PF14822.1 KII70042.1 - 0.026 13.6 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 Vasohibin zf-CCHC_5 PF14787.1 KII70042.1 - 0.21 11.1 2.1 0.41 10.1 1.5 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger rve PF00665.21 KII70044.1 - 1.9e-28 98.9 0.0 3.7e-28 98.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70044.1 - 0.0012 18.3 0.0 0.0027 17.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII70044.1 - 0.0073 16.2 0.4 0.058 13.3 0.0 2.1 2 0 0 2 2 2 1 DDE domain DcpS_C PF11969.3 KII70045.1 - 1.3e-23 83.3 0.1 2.4e-23 82.5 0.1 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.7 KII70045.1 - 0.00072 19.9 0.1 0.0027 18.0 0.0 2.0 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal HIT PF01230.18 KII70045.1 - 0.016 15.7 0.1 0.04 14.4 0.1 1.7 1 0 0 1 1 1 0 HIT domain DUF3432 PF11914.3 KII70046.1 - 0.35 10.9 5.9 0.84 9.6 4.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Cytadhesin_P30 PF07271.6 KII70046.1 - 4.4 6.4 7.4 6 6.0 5.2 1.2 1 0 0 1 1 1 0 Cytadhesin P30/P32 C_tripleX PF02363.14 KII70046.1 - 5.7 7.2 13.6 0.21 11.7 2.0 3.0 2 0 0 2 2 2 0 Cysteine rich repeat ShK PF01549.19 KII70047.1 - 2.3e-06 27.8 11.2 2.3e-06 27.8 7.7 2.7 3 1 0 3 3 3 1 ShK domain-like ShK PF01549.19 KII70049.1 - 2.2e-06 27.9 8.7 3.1e-06 27.4 6.1 1.2 1 0 0 1 1 1 1 ShK domain-like DUF793 PF05633.6 KII70049.1 - 0.0053 15.5 0.3 0.012 14.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF793) Complex1_LYR_2 PF13233.1 KII70049.1 - 0.047 14.1 0.2 0.057 13.9 0.1 1.3 1 0 0 1 1 1 0 Complex1_LYR-like Crisp PF08562.5 KII70049.1 - 1.1 9.5 9.8 2 8.7 6.8 1.4 1 0 0 1 1 1 0 Crisp PLAC PF08686.6 KII70049.1 - 2.5 8.4 9.4 5.4 7.3 6.5 1.6 1 1 0 1 1 1 0 PLAC (protease and lacunin) domain zf-nanos PF05741.8 KII70050.1 - 2.3e-22 78.6 2.9 4e-22 77.9 2.0 1.4 1 0 0 1 1 1 1 Nanos RNA binding domain zf-CCHC_2 PF13696.1 KII70050.1 - 0.031 13.7 0.2 0.1 12.0 0.1 1.9 1 0 0 1 1 1 0 Zinc knuckle IL7 PF01415.11 KII70050.1 - 0.087 12.4 0.2 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 Interleukin 7/9 family zf-HIT PF04438.11 KII70050.1 - 0.67 9.6 5.9 4.2 7.0 0.9 2.5 2 0 0 2 2 2 0 HIT zinc finger Aldo_ket_red PF00248.16 KII70053.1 - 1.1e-31 109.6 0.0 1.4e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HSCB_C PF07743.8 KII70053.1 - 0.00096 19.5 0.1 0.0018 18.6 0.1 1.4 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain Aldo_ket_red PF00248.16 KII70054.1 - 3.9e-55 186.6 0.0 4.6e-55 186.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII70055.1 - 3.2e-27 95.1 0.0 3.6e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family UPF0370 PF13980.1 KII70055.1 - 0.0059 16.3 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0370) DUF3006 PF11213.3 KII70057.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3006) Phage_gp53 PF11246.3 KII70057.1 - 0.14 11.5 1.0 0.19 11.1 0.5 1.3 1 1 0 1 1 1 0 Base plate wedge protein 53 Aldo_ket_red PF00248.16 KII70058.1 - 1.1e-08 34.2 0.1 1.3e-08 33.9 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII70059.1 - 5.3e-34 117.3 0.0 6e-34 117.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII70060.1 - 7.5e-10 38.0 0.1 9e-10 37.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4021 PF13213.1 KII70060.1 - 0.058 13.0 0.4 0.11 12.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4021) Aldo_ket_red PF00248.16 KII70061.1 - 4.6e-30 104.3 0.1 5.5e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4021 PF13213.1 KII70061.1 - 0.062 12.9 0.7 0.25 10.9 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4021) Aldo_ket_red PF00248.16 KII70063.1 - 1.6e-25 89.4 0.0 2e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII70066.1 - 2.4e-50 170.9 0.0 2.9e-50 170.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ripply PF14998.1 KII70067.1 - 0.089 12.9 0.9 3.7 7.7 0.1 2.5 1 1 1 2 2 2 0 Transcription Regulator OST3_OST6 PF04756.8 KII70070.1 - 1.6e-05 24.5 6.4 2.7e-05 23.8 4.4 1.4 1 0 0 1 1 1 1 OST3 / OST6 family DUF1129 PF06570.6 KII70070.1 - 0.045 13.0 2.7 0.089 12.0 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) hEGF PF12661.2 KII70071.1 - 0.21 11.7 5.8 0.16 12.0 1.7 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF Fer4_6 PF12837.2 KII70071.1 - 0.59 10.0 9.8 0.24 11.3 1.3 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain E1_DerP2_DerF2 PF02221.10 KII70072.1 - 2.2e-19 70.0 0.7 2.6e-19 69.7 0.5 1.1 1 0 0 1 1 1 1 ML domain KH_1 PF00013.24 KII70074.1 - 9e-31 105.3 16.7 7.7e-08 31.8 0.0 10.1 11 0 0 11 11 11 5 KH domain KH_3 PF13014.1 KII70074.1 - 3.5e-18 64.8 11.0 1.8e-05 24.2 0.0 8.5 10 0 0 10 10 10 5 KH domain SNAP PF14938.1 KII70075.1 - 0.0059 15.7 0.8 0.0085 15.2 0.5 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SopA_C PF13979.1 KII70075.1 - 0.012 15.2 0.7 0.5 9.9 0.1 2.3 1 1 1 2 2 2 0 SopA-like catalytic domain PGA2 PF07543.7 KII70075.1 - 0.058 13.1 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 RNA_pol_Rpb2_7 PF04560.15 KII70075.1 - 0.12 12.6 0.6 1.4 9.2 0.2 2.5 2 1 0 2 2 2 0 RNA polymerase Rpb2, domain 7 SNAP PF14938.1 KII70077.1 - 0.0043 16.2 0.6 0.0054 15.9 0.4 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NSF PF02071.15 KII70077.1 - 7 7.7 9.8 5.1 8.1 0.1 3.8 4 1 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TMEM52 PF14979.1 KII70078.1 - 0.00015 21.7 0.2 0.00029 20.7 0.1 1.5 1 0 0 1 1 1 1 Transmembrane 52 Adeno_E3B PF03376.9 KII70078.1 - 0.26 11.1 4.5 0.65 9.9 3.1 1.6 1 0 0 1 1 1 0 Adenovirus E3B protein Glyco_transf_54 PF04666.8 KII70080.1 - 5.1e-37 127.2 0.7 6.9e-37 126.7 0.5 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Cys_Met_Meta_PP PF01053.15 KII70081.1 - 5e-25 87.5 0.0 5.5e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 KII70081.1 - 0.00015 20.9 0.0 0.00017 20.7 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 KII70081.1 - 0.042 12.9 0.0 0.046 12.8 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase Ribosomal_L18ae PF01775.12 KII70082.1 - 1.6e-45 154.0 2.4 2.3e-45 153.5 1.7 1.2 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain DUF4160 PF13711.1 KII70082.1 - 0.017 14.9 0.1 0.04 13.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) RVT_1 PF00078.22 KII70083.1 - 0.063 12.6 0.4 4.9 6.4 0.1 2.3 1 1 1 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII70084.1 - 0.00018 21.6 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS1595 PF12762.2 KII70085.1 - 0.11 12.3 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain MMR_HSR1 PF01926.18 KII70086.1 - 3e-14 52.9 0.1 3.6e-13 49.4 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KII70086.1 - 1.2e-06 27.9 0.0 8.4e-05 21.8 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 KII70086.1 - 4.2e-05 22.7 0.1 9e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 TrwB_AAD_bind PF10412.4 KII70086.1 - 0.039 12.5 0.0 0.065 11.8 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.18 KII70086.1 - 0.07 12.9 2.3 0.76 9.5 0.2 3.0 2 1 1 3 3 3 0 Dynamin family Miro PF08477.8 KII70086.1 - 0.15 12.5 1.1 1 9.8 0.0 2.6 3 0 0 3 3 3 0 Miro-like protein Med13_C PF06333.7 KII70088.1 - 2.8 6.3 6.6 2.9 6.3 4.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal Clat_adaptor_s PF01217.15 KII70090.1 - 9.1e-24 83.7 5.9 2.4e-23 82.4 4.1 1.6 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Orthoreo_P17 PF07272.6 KII70090.1 - 0.11 12.2 0.7 0.15 11.8 0.1 1.4 2 0 0 2 2 2 0 Orthoreovirus P17 protein Clat_adaptor_s PF01217.15 KII70091.1 - 2.2e-25 89.0 3.2 2.4e-25 88.8 2.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DDE_3 PF13358.1 KII70092.1 - 0.0054 16.4 0.0 0.0082 15.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII70093.1 - 0.0001 22.3 0.1 0.00012 22.1 0.1 1.1 1 0 0 1 1 1 1 Integrase core domain DUF2783 PF10932.3 KII70093.1 - 0.13 11.7 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) CRC_subunit PF08624.5 KII70097.1 - 0.058 13.3 0.1 0.15 12.0 0.0 1.6 1 1 1 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit MULE PF10551.4 KII70099.1 - 0.0017 18.4 0.3 0.0046 17.0 0.1 1.8 2 0 0 2 2 2 1 MULE transposase domain Transposase_mut PF00872.13 KII70099.1 - 0.067 11.7 0.1 0.14 10.6 0.0 1.5 2 0 0 2 2 2 0 Transposase, Mutator family DUF3780 PF12635.2 KII70099.1 - 0.12 11.8 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3780) Myb_DNA-bind_5 PF13873.1 KII70100.1 - 8.2e-12 44.8 4.9 1.5e-11 43.9 3.4 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Med7 PF05983.6 KII70100.1 - 0.076 12.7 1.7 0.14 11.8 1.2 1.4 1 0 0 1 1 1 0 MED7 protein ORC3_N PF07034.6 KII70100.1 - 0.12 11.3 1.1 0.2 10.6 0.7 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus Myb_DNA-bind_6 PF13921.1 KII70100.1 - 0.17 12.0 2.0 0.47 10.5 1.4 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain HCV_NS5a PF01506.14 KII70101.1 - 4.5 7.0 5.5 0.86 9.3 0.6 2.2 2 0 0 2 2 2 0 Hepatitis C virus non-structural 5a protein membrane anchor DUF2516 PF10724.4 KII70103.1 - 0.042 13.8 0.3 0.069 13.1 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2516) RebB PF11747.3 KII70104.1 - 0.074 12.9 0.7 0.14 12.0 0.5 1.4 1 0 0 1 1 1 0 Killing trait Y1_Tnp PF01797.11 KII70105.1 - 0.046 13.5 0.2 0.07 12.9 0.1 1.3 1 0 0 1 1 1 0 Transposase IS200 like MCC-bdg_PDZ PF10506.4 KII70108.1 - 0.025 14.4 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DDE_3 PF13358.1 KII70113.1 - 2.2e-22 79.3 0.0 3.2e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII70113.1 - 2.4e-06 27.6 0.0 4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain LolA PF03548.10 KII70113.1 - 0.083 12.4 0.0 0.098 12.2 0.0 1.1 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA DDE_1 PF03184.14 KII70113.1 - 0.09 11.8 0.0 0.097 11.7 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Glycos_transf_2 PF00535.21 KII70116.1 - 0.00015 21.4 0.6 0.0011 18.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII70116.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.3 1 1 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KII70116.1 - 0.056 13.1 0.0 0.056 13.1 0.0 1.3 1 1 0 1 1 1 0 Glycosyl transferase family group 2 DDE_3 PF13358.1 KII70118.1 - 5.2e-05 23.0 0.3 0.00023 20.9 0.1 1.8 1 1 1 2 2 2 1 DDE superfamily endonuclease Bac_transf PF02397.11 KII70118.1 - 0.11 11.5 0.0 0.11 11.5 0.0 1.3 1 1 0 1 1 1 0 Bacterial sugar transferase DC_STAMP PF07782.8 KII70120.1 - 0.011 15.4 0.1 2.1 7.9 0.0 2.0 2 0 0 2 2 2 0 DC-STAMP-like protein CENP-B_dimeris PF09026.5 KII70120.1 - 0.11 12.7 0.5 0.16 12.2 0.1 1.5 1 1 0 1 1 1 0 Centromere protein B dimerisation domain DUF1048 PF06304.6 KII70121.1 - 0.14 12.5 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) Kelch_6 PF13964.1 KII70122.1 - 8.8e-17 60.4 6.4 0.00014 21.8 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII70122.1 - 1e-16 60.1 10.0 8.2e-06 25.2 1.2 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII70122.1 - 3.4e-14 52.3 1.4 0.0012 18.5 0.0 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII70122.1 - 1.7e-13 50.2 2.3 0.00037 20.5 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII70122.1 - 2.3e-10 40.1 3.6 0.0006 19.7 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII70122.1 - 1.3e-06 27.8 3.8 0.29 10.9 0.0 3.4 3 0 0 3 3 3 3 Kelch motif zf-CCHC PF00098.18 KII70123.1 - 0.00018 21.2 1.7 0.00027 20.7 1.2 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.1 KII70123.1 - 0.00027 20.3 1.1 0.00043 19.6 0.7 1.3 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 KII70123.1 - 0.021 14.4 1.5 0.037 13.7 0.6 1.8 2 0 0 2 2 2 0 Zinc knuckle Invasin_D3 PF09134.5 KII70124.1 - 0.1 12.5 0.1 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Invasin, domain 3 USP7_ICP0_bdg PF12436.3 KII70124.1 - 0.15 11.3 0.4 2.5 7.2 0.0 2.1 2 0 0 2 2 2 0 ICP0-binding domain of Ubiquitin-specific protease 7 zf-CCCH PF00642.19 KII70126.1 - 1.7e-08 33.9 8.9 1.1e-05 24.9 1.2 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Mss4 PF04421.8 KII70126.1 - 0.025 14.4 0.7 0.5 10.2 0.0 2.2 2 0 0 2 2 2 0 Mss4 protein zf-CSL PF05207.8 KII70126.1 - 0.029 13.8 0.1 0.057 12.9 0.1 1.5 1 0 0 1 1 1 0 CSL zinc finger zf-CCCH_2 PF14608.1 KII70126.1 - 0.33 11.0 13.8 0.37 10.8 1.5 3.2 2 1 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type Ank_2 PF12796.2 KII70127.1 - 1.9e-30 105.0 0.0 1.4e-14 54.2 0.0 2.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KII70127.1 - 4.7e-17 61.6 0.1 3.3e-06 27.1 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KII70127.1 - 6.3e-17 60.4 0.0 1.5e-05 24.5 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 KII70127.1 - 5.1e-12 44.8 0.0 0.0037 17.3 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KII70127.1 - 8.2e-12 45.3 0.0 2.1e-07 31.2 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) SH3_9 PF14604.1 KII70127.1 - 2e-06 27.3 0.0 4.8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KII70127.1 - 0.0034 16.8 0.0 0.011 15.2 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain DUF3447 PF11929.3 KII70127.1 - 0.019 14.7 0.1 1.5 8.6 0.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3447) SH3_1 PF00018.23 KII70127.1 - 0.033 13.5 0.0 0.07 12.5 0.0 1.5 1 0 0 1 1 1 0 SH3 domain BSD PF03909.12 KII70128.1 - 7.3e-10 38.4 0.1 1.8e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 BSD domain Got1 PF04178.7 KII70130.1 - 2.7e-12 46.8 19.5 3.1e-12 46.6 13.5 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family DUF308 PF03729.8 KII70130.1 - 4.2 7.4 24.8 0.23 11.5 6.4 2.4 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) zf-DNL PF05180.7 KII70131.1 - 4.1e-27 93.6 2.2 6e-27 93.1 1.5 1.3 1 0 0 1 1 1 1 DNL zinc finger DUF2175 PF09943.4 KII70131.1 - 0.11 12.6 0.2 0.15 12.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) zf-C2HC PF01530.13 KII70131.1 - 0.14 11.9 1.7 0.21 11.3 0.2 1.9 2 0 0 2 2 2 0 Zinc finger, C2HC type Adeno_E4_34 PF04528.8 KII70131.1 - 0.19 11.2 1.3 0.3 10.6 0.9 1.3 1 1 0 1 1 1 0 Adenovirus early E4 34 kDa protein conserved region Cation_ATPase_C PF00689.16 KII70132.1 - 1.6e-38 132.0 2.9 2.2e-38 131.6 2.0 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KII70132.1 - 1.1e-21 78.2 0.0 2e-21 77.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KII70132.1 - 2.2e-09 37.7 0.0 4.5e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KII70132.1 - 4.1e-05 23.2 0.3 0.013 15.1 0.1 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 KII70133.1 - 3.6e-57 193.0 4.4 3.6e-57 193.0 3.1 1.6 1 1 1 2 2 2 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 KII70133.1 - 1.3e-18 66.7 0.4 7.9e-18 64.2 0.0 2.1 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 KII70133.1 - 5.3e-06 25.8 0.0 1.1e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 KII70133.1 - 0.00072 19.7 0.1 0.0018 18.4 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4149 PF13664.1 KII70133.1 - 0.0088 16.0 0.1 0.0088 16.0 0.1 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4149) BRICHOS PF04089.9 KII70133.1 - 0.021 14.6 0.1 0.19 11.6 0.0 2.6 3 0 0 3 3 3 0 BRICHOS domain Hydrolase PF00702.21 KII70133.1 - 0.024 15.0 0.0 0.036 14.4 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase FAM60A PF15396.1 KII70135.1 - 7.8e-08 32.3 3.5 1.2e-07 31.6 0.0 2.0 2 0 0 2 2 2 1 Protein Family FAM60A Rep_fac-A_C PF08646.5 KII70136.1 - 2.2e-39 134.4 0.5 1.8e-36 125.0 0.0 2.6 3 0 0 3 3 3 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 KII70136.1 - 9.2e-08 31.8 0.1 6.3e-05 22.7 0.0 2.7 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain IBR PF01485.16 KII70136.1 - 0.0016 18.2 0.9 0.0034 17.2 0.7 1.5 1 0 0 1 1 1 1 IBR domain Evr1_Alr PF04777.8 KII70136.1 - 0.028 14.3 0.9 0.073 12.9 0.6 1.6 1 0 0 1 1 1 0 Erv1 / Alr family zinc-ribbons_6 PF07191.7 KII70136.1 - 0.25 11.1 2.0 0.47 10.2 1.4 1.4 1 0 0 1 1 1 0 zinc-ribbons Hydrolase PF00702.21 KII70137.1 - 1.5e-06 28.7 0.0 1.6e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KII70137.1 - 5.2e-05 23.5 0.0 6.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF87 PF01935.12 KII70137.1 - 0.0017 18.2 0.1 0.0022 17.8 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function DUF87 GreA_GreB_N PF03449.10 KII70137.1 - 0.0053 16.7 0.4 0.021 14.8 0.1 2.1 2 1 0 2 2 2 1 Transcription elongation factor, N-terminal Hydrolase_like2 PF13246.1 KII70137.1 - 0.0077 16.1 0.1 0.12 12.3 0.0 2.4 2 1 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD_2 PF13419.1 KII70137.1 - 0.014 15.6 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase NYN_YacP PF05991.6 KII70137.1 - 0.034 13.8 0.0 0.085 12.6 0.0 1.6 1 1 0 1 1 1 0 YacP-like NYN domain HSP20 PF00011.16 KII70138.1 - 3.2e-27 94.3 2.1 7e-16 57.9 0.5 2.0 1 1 1 2 2 2 2 Hsp20/alpha crystallin family DDE_Tnp_IS1595 PF12762.2 KII70139.1 - 7.4e-07 29.1 0.0 1.1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DNA_primase_lrg PF04104.9 KII70141.1 - 2.9e-09 36.5 0.1 5.6e-09 35.6 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit PhnH PF05845.7 KII70142.1 - 0.11 11.9 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnH) Ribosomal_L10 PF00466.15 KII70143.1 - 9e-19 67.2 2.1 1.5e-18 66.5 1.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 DUF3324 PF11797.3 KII70143.1 - 0.047 13.4 0.4 0.11 12.1 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function C-terminal (DUF3324) polyprenyl_synt PF00348.12 KII70144.1 - 1e-45 155.6 0.2 1.3e-44 152.0 0.1 2.0 1 1 0 1 1 1 1 Polyprenyl synthetase DUF1896 PF08989.5 KII70144.1 - 0.07 13.0 0.1 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1896) DUF663 PF04950.7 KII70146.1 - 2.3e-77 259.9 3.1 4e-77 259.1 2.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 KII70146.1 - 2.2e-24 84.7 0.1 9.6e-24 82.7 0.0 2.1 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 KII70146.1 - 7.5e-05 22.2 0.0 0.00019 20.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Spore_coat_CotO PF14153.1 KII70146.1 - 0.0033 16.8 11.2 0.0033 16.8 7.7 1.9 2 0 0 2 2 2 1 Spore coat protein CotO FGF-BP1 PF06473.7 KII70146.1 - 5.6 6.4 7.8 9.8 5.6 5.4 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) PDZ PF00595.19 KII70147.1 - 4.1e-09 36.4 0.0 9.4e-05 22.5 0.0 2.8 2 1 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII70147.1 - 1.2e-05 25.1 0.0 3.9e-05 23.4 0.0 1.8 2 1 0 2 2 2 1 PDZ domain DUF2358 PF10184.4 KII70148.1 - 0.047 13.6 0.1 0.89 9.4 0.0 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2358) MerR_1 PF13411.1 KII70152.1 - 0.03 14.0 0.2 0.039 13.7 0.2 1.2 1 0 0 1 1 1 0 MerR HTH family regulatory protein RRM_1 PF00076.17 KII70153.1 - 1.4e-20 72.7 0.0 2.2e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII70153.1 - 4.7e-16 58.5 0.0 7.5e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.3 KII70153.1 - 4.4e-15 55.7 3.8 4.4e-15 55.7 2.6 2.9 2 2 1 3 3 3 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_5 PF13893.1 KII70153.1 - 5e-11 42.2 0.0 8.1e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PEPCK PF00821.13 KII70155.1 - 2.8e-107 359.3 0.0 3e-107 359.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase SYF2 PF08231.7 KII70156.1 - 0.024 14.7 1.0 0.029 14.4 0.7 1.1 1 0 0 1 1 1 0 SYF2 splicing factor Autophagy_Cterm PF10381.4 KII70157.1 - 0.45 9.6 0.1 0.45 9.6 0.0 2.1 2 0 0 2 2 2 0 Autophagocytosis associated protein C-terminal Se-cys_synth_N PF12390.3 KII70158.1 - 0.069 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Selenocysteine synthase N terminal SET PF00856.23 KII70159.1 - 9.1e-17 61.8 0.5 3e-16 60.1 0.0 2.0 2 1 0 2 2 2 1 SET domain Acyl-thio_N PF12590.3 KII70159.1 - 0.097 13.1 0.6 3.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Acyl-ATP thioesterase Proteasome PF00227.21 KII70160.1 - 1.5e-39 135.2 0.0 2e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KII70160.1 - 7.3e-12 44.3 0.1 1.4e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF2191 PF09957.4 KII70160.1 - 0.24 11.2 0.3 0.24 11.2 0.2 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2191) DDE_3 PF13358.1 KII70161.1 - 1.2e-22 80.2 0.1 4.2e-22 78.4 0.0 1.9 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII70161.1 - 5.4e-05 22.6 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII70161.1 - 0.0088 16.0 0.2 0.079 13.0 0.0 2.2 2 0 0 2 2 2 1 Transposase DUF3908 PF13048.1 KII70165.1 - 0.25 11.3 3.4 0.35 10.8 2.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3908) Ldl_recept_a PF00057.13 KII70166.1 - 3.5e-10 39.5 47.2 0.00063 19.5 5.7 3.5 3 1 0 3 3 3 3 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII70167.1 - 4.7e-24 84.0 43.2 4e-12 45.8 8.4 4.6 4 1 0 4 4 4 3 Low-density lipoprotein receptor domain class A Reprolysin_2 PF13574.1 KII70168.1 - 3.3e-16 59.8 0.6 4e-16 59.5 0.4 1.0 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 KII70168.1 - 4.1e-11 43.1 0.6 4.7e-11 42.9 0.4 1.0 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 KII70168.1 - 8.9e-11 41.7 0.1 9.8e-11 41.5 0.1 1.1 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 KII70168.1 - 1.3e-08 35.3 0.1 1.9e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.14 KII70168.1 - 4.3e-07 29.7 0.0 5.7e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M10 PF00413.19 KII70168.1 - 0.0066 16.1 0.2 0.011 15.5 0.1 1.4 1 1 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.4 KII70168.1 - 0.054 12.3 0.0 0.057 12.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M43 PF05572.8 KII70168.1 - 0.061 12.9 0.0 0.086 12.4 0.0 1.2 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A DUF3152 PF11350.3 KII70168.1 - 0.07 12.6 0.1 0.092 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3152) Peptidase_M85 PF13678.1 KII70168.1 - 0.082 12.2 0.2 0.1 11.9 0.1 1.1 1 0 0 1 1 1 0 NFkB-p65-degrading zinc protease Peptidase_M64 PF09471.5 KII70168.1 - 0.091 12.3 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 IgA Peptidase M64 Reprolysin_2 PF13574.1 KII70169.1 - 3.3e-14 53.3 1.5 6.3e-14 52.4 0.2 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 KII70169.1 - 2.5e-10 40.2 0.1 4.3e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 KII70169.1 - 4.2e-09 36.6 0.9 7.2e-09 35.8 0.4 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 KII70169.1 - 9.3e-06 26.1 0.1 1.9e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.14 KII70169.1 - 1e-05 25.2 0.1 1.9e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M10 PF00413.19 KII70169.1 - 0.005 16.5 0.3 0.008 15.9 0.2 1.4 1 1 0 1 1 1 1 Matrixin Pox_F12L PF03337.8 KII70169.1 - 0.019 12.9 0.0 0.029 12.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus F12L protein Peptidase_C12 PF01088.16 KII70169.1 - 0.028 13.6 0.4 0.045 12.9 0.0 1.5 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF4181 PF13789.1 KII70170.1 - 0.0099 15.7 0.1 0.016 15.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4181) Usp PF00582.21 KII70171.1 - 3e-18 66.3 0.0 4.4e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Universal stress protein family Usp PF00582.21 KII70172.1 - 5.2e-13 49.3 0.0 6.6e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family ESAG1 PF03238.8 KII70172.1 - 0.092 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 ESAG protein DUF4371 PF14291.1 KII70173.1 - 8.7e-05 22.1 0.9 0.00016 21.3 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) UNC-93 PF05978.11 KII70174.1 - 0.016 14.7 0.6 0.024 14.1 0.4 1.2 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 Rab5ip PF07019.7 KII70175.1 - 4.1e-09 36.4 1.0 5.2e-09 36.1 0.7 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF3177 PF11375.3 KII70175.1 - 0.088 12.2 0.4 0.11 11.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3177) HTH_Tnp_Tc5 PF03221.11 KII70176.1 - 5.2e-08 32.5 0.8 9.2e-08 31.7 0.6 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_3 PF01381.17 KII70176.1 - 0.00085 19.1 0.4 0.0016 18.2 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_23 PF13384.1 KII70176.1 - 0.013 15.1 0.6 0.047 13.3 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain HTH_IclR PF09339.5 KII70176.1 - 0.015 14.8 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_38 PF13936.1 KII70176.1 - 0.04 13.4 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.8 KII70176.1 - 0.056 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain LacI PF00356.16 KII70176.1 - 0.074 12.6 0.0 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family HTH_psq PF05225.11 KII70176.1 - 0.087 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Usp PF00582.21 KII70177.1 - 0.0014 18.7 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 Universal stress protein family COX6B PF02297.12 KII70177.1 - 0.051 13.5 0.4 0.09 12.7 0.3 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb DUF1749 PF08538.5 KII70177.1 - 0.06 12.2 0.7 0.07 12.0 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1749) MFS_1 PF07690.11 KII70179.1 - 2.8e-09 36.1 0.1 3e-09 36.0 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.8 KII70179.1 - 0.00028 19.1 3.0 0.081 11.0 0.3 2.0 1 1 1 2 2 2 2 Transmembrane secretion effector MFS_2 PF13347.1 KII70179.1 - 0.00043 18.7 5.1 0.29 9.4 2.3 2.0 2 0 0 2 2 2 2 MFS/sugar transport protein Nuc_H_symport PF03825.11 KII70179.1 - 0.0066 15.2 7.1 0.0078 15.0 4.9 1.1 1 0 0 1 1 1 1 Nucleoside H+ symporter MARVEL PF01284.18 KII70179.1 - 0.036 13.8 4.3 0.065 13.0 1.1 2.0 2 0 0 2 2 2 0 Membrane-associating domain LacY_symp PF01306.14 KII70179.1 - 0.048 12.1 2.6 0.057 11.9 1.8 1.0 1 0 0 1 1 1 0 LacY proton/sugar symporter BT1 PF03092.11 KII70179.1 - 0.054 12.2 0.3 0.059 12.0 0.2 1.1 1 0 0 1 1 1 0 BT1 family UNC-93 PF05978.11 KII70179.1 - 0.73 9.3 6.6 0.23 10.9 1.8 1.9 1 1 1 2 2 2 0 Ion channel regulatory protein UNC-93 MRG PF05712.8 KII70180.1 - 5e-17 61.4 5.4 3.4e-16 58.7 3.7 1.9 1 1 0 1 1 1 1 MRG EF-hand_7 PF13499.1 KII70182.1 - 2.5e-14 53.1 7.3 2.8e-08 33.7 3.5 3.2 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.27 KII70182.1 - 2.8e-13 48.1 11.6 3.9e-06 25.7 1.1 5.0 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 KII70182.1 - 1.1e-11 43.6 6.7 2e-05 24.0 0.6 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 KII70182.1 - 1.1e-08 34.5 10.7 3.5e-05 23.3 0.0 4.9 2 1 3 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 KII70182.1 - 7.7e-08 31.3 2.4 5e-05 22.4 0.4 3.4 3 0 0 3 3 3 2 EF hand DUF2246 PF10229.4 KII70183.1 - 2.4e-10 40.1 0.2 2.5e-10 40.1 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2246) DUF2543 PF10820.3 KII70183.1 - 0.025 14.5 0.1 8.3 6.5 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2543) ELFV_dehydrog PF00208.16 KII70184.1 - 9.1e-49 166.2 0.1 1.1e-47 162.7 0.1 2.0 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 KII70184.1 - 1e-43 148.0 0.0 1.8e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Peptidase_C1 PF00112.18 KII70186.1 - 1.3e-28 100.4 0.0 2.3e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII70186.1 - 3.1e-09 36.9 5.6 4.8e-09 36.3 3.9 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF694 PF05107.7 KII70186.1 - 0.0032 16.7 0.1 0.0039 16.4 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF694) Nucleoporin_N PF08801.6 KII70188.1 - 7.9e-09 34.7 4.0 2.3e-07 29.9 2.8 2.4 1 1 0 1 1 1 1 Nup133 N terminal like Drf_GBD PF06371.8 KII70188.1 - 0.018 14.3 0.7 0.035 13.4 0.5 1.4 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Metalloenzyme PF01676.13 KII70191.1 - 4.7e-71 239.1 0.0 5.5e-71 238.9 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.8 KII70191.1 - 5.1e-65 218.9 0.0 6.6e-65 218.5 0.0 1.1 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.17 KII70191.1 - 4.1e-06 26.3 0.0 4.1e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 KII70191.1 - 0.092 11.9 0.0 0.63 9.1 0.0 2.2 2 0 0 2 2 2 0 Sulfatase LANC_like PF05147.8 KII70193.1 - 1.5e-61 207.9 0.2 1.8e-61 207.6 0.1 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_88 PF07470.8 KII70193.1 - 0.019 13.9 0.8 0.054 12.5 0.6 1.6 1 1 0 1 1 1 0 Glycosyl Hydrolase Family 88 Fe-S_biosyn PF01521.15 KII70194.1 - 0.072 13.0 0.8 7.4 6.5 0.0 2.3 2 0 0 2 2 2 0 Iron-sulphur cluster biosynthesis PAT1 PF09770.4 KII70195.1 - 0.28 9.3 42.5 0.32 9.1 29.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF605 PF04652.11 KII70195.1 - 0.3 10.4 42.2 0.37 10.1 29.2 1.1 1 0 0 1 1 1 0 Vta1 like ArfGap PF01412.13 KII70196.1 - 6.8e-36 122.5 0.6 2.3e-35 120.9 0.4 2.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf RNase_PH PF01138.16 KII70200.1 - 2.3e-10 40.9 0.0 3.1e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 FF PF01846.14 KII70202.1 - 0.14 12.1 4.0 0.22 11.4 0.1 2.4 3 0 0 3 3 3 0 FF domain HTH_Tnp_Tc5 PF03221.11 KII70203.1 - 6.1e-10 38.7 0.0 1.5e-09 37.5 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain MarR PF01047.17 KII70203.1 - 0.046 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 MarR family GNT-I PF03071.10 KII70205.1 - 9.2e-14 50.8 1.0 4.9e-13 48.4 0.7 1.8 1 1 0 1 1 1 1 GNT-I family DUF1090 PF06476.7 KII70206.1 - 0.11 12.1 0.2 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) Imm24 PF15570.1 KII70212.1 - 0.39 10.4 3.1 4.5 7.0 0.1 2.2 1 1 1 2 2 2 0 Immunity protein 24 rve PF00665.21 KII70213.1 - 3.6e-11 43.2 0.0 4.3e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70213.1 - 0.00024 20.5 0.0 0.00032 20.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain PMG PF05287.7 KII70217.1 - 0.0034 17.1 7.2 0.0064 16.3 5.0 1.4 1 0 0 1 1 1 1 PMG protein Toxin_2 PF00451.14 KII70220.1 - 2.3 8.3 11.2 0.37 10.9 1.6 3.0 3 0 0 3 3 3 0 Scorpion short toxin, BmKK2 Dimer_Tnp_hAT PF05699.9 KII70221.1 - 0.00098 18.6 0.2 0.0021 17.6 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region ABC_trans_N PF14510.1 KII70221.1 - 0.16 12.0 1.2 2.4 8.3 0.0 2.7 1 1 1 2 2 2 0 ABC-transporter extracellular N-terminal Prenyltrans PF00432.16 KII70222.1 - 1.2e-42 143.0 11.2 1.1e-11 44.0 0.4 5.5 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 KII70222.1 - 4.8e-26 91.3 0.0 1.9e-15 57.2 0.0 3.3 2 1 1 3 3 3 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 KII70222.1 - 1.9e-05 24.6 0.0 0.00054 19.9 0.0 3.0 2 1 2 4 4 4 2 Prenyltransferase-like Fibrinogen_C PF00147.13 KII70222.1 - 0.017 14.7 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain HTH_29 PF13551.1 KII70223.1 - 1.8e-12 47.4 0.3 4e-11 43.0 0.0 2.2 1 1 1 2 2 2 2 Winged helix-turn helix DDE_3 PF13358.1 KII70223.1 - 2.4e-11 43.5 0.2 6.6e-11 42.1 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_32 PF13565.1 KII70223.1 - 3.7e-08 34.0 0.6 7.2e-06 26.7 0.0 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_33 PF13592.1 KII70223.1 - 9.7e-05 21.8 0.0 0.0002 20.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII70223.1 - 0.001 18.6 0.1 0.0063 16.1 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII70223.1 - 0.0018 18.2 0.7 0.0039 17.1 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain GHL6 PF14871.1 KII70223.1 - 0.0033 17.4 0.0 0.0055 16.7 0.0 1.4 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase 6 PAX PF00292.13 KII70223.1 - 0.0036 16.9 0.1 0.01 15.5 0.0 1.8 2 0 0 2 2 2 1 'Paired box' domain Sigma70_r4_2 PF08281.7 KII70223.1 - 0.065 12.7 0.0 0.33 10.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 MarR_2 PF12802.2 KII70223.1 - 0.092 12.4 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 MarR family DDE_3 PF13358.1 KII70224.1 - 5.4e-12 45.6 0.0 7.8e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII70225.1 - 2.5e-13 50.1 0.5 1.1e-11 44.8 0.0 2.3 1 1 1 2 2 2 2 Winged helix-turn helix HTH_32 PF13565.1 KII70225.1 - 8.6e-10 39.2 1.2 4.9e-07 30.4 0.0 2.8 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.1 KII70225.1 - 0.00011 22.0 1.2 0.0013 18.6 0.0 2.8 3 1 0 3 3 3 1 Helix-turn-helix domain HTH_23 PF13384.1 KII70225.1 - 0.00013 21.4 0.0 0.002 17.6 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain PAX PF00292.13 KII70225.1 - 0.0023 17.6 0.1 0.0066 16.1 0.0 1.7 1 1 1 2 2 2 1 'Paired box' domain Sigma70_r4_2 PF08281.7 KII70225.1 - 0.029 13.8 0.1 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_21 PF13276.1 KII70225.1 - 0.032 14.2 0.0 0.095 12.7 0.0 1.8 1 0 0 1 1 1 0 HTH-like domain DDE_Tnp_IS66 PF03050.9 KII70225.1 - 0.057 12.6 0.0 0.097 11.8 0.0 1.4 1 0 0 1 1 1 0 Transposase IS66 family HTH_Tnp_Tc3_2 PF01498.13 KII70225.1 - 0.086 12.9 0.6 0.87 9.6 0.0 2.6 2 2 0 2 2 2 0 Transposase HTH_38 PF13936.1 KII70225.1 - 0.11 12.1 0.5 2.8 7.5 0.0 2.7 2 1 0 2 2 2 0 Helix-turn-helix domain DNA_pol_E_B PF04042.11 KII70226.1 - 5e-25 87.9 0.7 9e-25 87.1 0.5 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B LCAT PF02450.10 KII70227.1 - 5e-43 147.5 1.3 1.1e-34 120.0 0.3 2.1 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 KII70227.1 - 1.2e-06 28.6 0.0 1.9e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 KII70227.1 - 8.4e-06 25.5 0.0 1.3e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 KII70227.1 - 0.00028 20.6 0.0 0.00054 19.7 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.6 KII70227.1 - 0.0088 15.1 0.1 0.042 12.9 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.15 KII70227.1 - 0.079 12.3 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DDE_3 PF13358.1 KII70229.1 - 7.7e-07 28.9 0.0 1.1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Ank_2 PF12796.2 KII70230.1 - 0.0014 18.9 0.5 0.0028 17.9 0.3 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KII70230.1 - 0.0016 18.1 0.1 0.0046 16.7 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 KII70230.1 - 0.087 13.1 0.7 0.89 9.9 0.1 2.7 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.1 KII70230.1 - 0.088 13.0 0.1 0.3 11.3 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DUF1343 PF07075.6 KII70230.1 - 0.18 10.6 1.0 0.36 9.6 0.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1343) BatD PF13584.1 KII70234.1 - 0.0027 16.3 0.2 0.0037 15.9 0.1 1.2 1 0 0 1 1 1 1 Oxygen tolerance DUF4064 PF13273.1 KII70234.1 - 0.0048 16.9 0.1 0.009 16.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) DUF912 PF06024.7 KII70234.1 - 0.024 14.6 0.1 0.056 13.4 0.1 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) NapE PF06796.6 KII70234.1 - 0.043 13.1 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE Vma12 PF11712.3 KII70234.1 - 0.051 13.2 0.0 0.089 12.4 0.0 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase IU_nuc_hydro PF01156.14 KII70235.1 - 5.5e-36 124.3 0.0 6.7e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase RVP_2 PF08284.6 KII70241.1 - 1.4e-05 25.0 0.0 2.9e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII70241.1 - 2.5e-05 24.7 0.0 7.2e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII70241.1 - 0.00013 21.5 0.0 0.00048 19.6 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KII70241.1 - 0.00021 21.0 0.0 0.00043 20.0 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII70241.1 - 0.0004 20.2 0.0 0.0011 18.9 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF2414 PF10309.4 KII70241.1 - 0.015 14.9 0.1 0.039 13.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2414) RPAP2_Rtr1 PF04181.8 KII70241.1 - 0.043 13.9 0.1 0.043 13.9 0.0 2.6 2 1 1 3 3 3 0 Rtr1/RPAP2 family rve PF00665.21 KII70242.1 - 3.2e-21 75.6 0.0 9.5e-21 74.1 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain PH PF00169.24 KII70245.1 - 4e-13 49.4 0.5 1.2e-12 47.9 0.3 1.8 1 0 0 1 1 1 1 PH domain START PF01852.14 KII70245.1 - 3.3e-06 26.5 0.2 4.4e-05 22.9 0.0 2.4 2 1 0 2 2 2 1 START domain PH_11 PF15413.1 KII70245.1 - 7.5e-05 22.9 3.5 0.004 17.3 1.2 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.1 KII70245.1 - 0.00058 19.8 0.3 0.0014 18.6 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.1 KII70245.1 - 0.00077 19.4 0.0 0.0019 18.2 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Bacillus_HBL PF05791.6 KII70245.1 - 0.0014 18.0 2.6 0.038 13.3 0.2 2.6 2 0 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) THOC7 PF05615.8 KII70245.1 - 0.013 15.8 1.4 0.013 15.8 1.0 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 Syntaxin_2 PF14523.1 KII70245.1 - 0.021 14.8 2.9 0.13 12.3 0.3 2.5 2 0 0 2 2 2 0 Syntaxin-like protein DUF713 PF05218.9 KII70245.1 - 0.036 13.7 4.1 1.6 8.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF713) DUF2570 PF10828.3 KII70245.1 - 0.052 13.1 0.7 0.13 11.9 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) Tmemb_cc2 PF10267.4 KII70245.1 - 0.24 9.9 5.2 0.17 10.4 0.5 2.1 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DUF2762 PF10960.3 KII70245.1 - 0.51 10.0 5.0 0.22 11.2 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2762) FlxA PF14282.1 KII70245.1 - 1.1 9.2 7.8 5.4 7.0 0.1 2.5 2 0 0 2 2 2 0 FlxA-like protein Prefoldin PF02996.12 KII70245.1 - 2.4 7.8 7.7 7.4 6.2 2.6 2.5 2 0 0 2 2 2 0 Prefoldin subunit DDE_3 PF13358.1 KII70247.1 - 3.6e-07 30.0 0.0 4.5e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve_2 PF13333.1 KII70248.1 - 0.02 14.9 0.8 0.038 14.0 0.2 1.7 1 1 1 2 2 2 0 Integrase core domain DUF2573 PF10835.3 KII70248.1 - 0.066 13.2 0.2 0.094 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2573) NT5C PF06941.7 KII70248.1 - 0.16 11.4 0.7 0.24 10.8 0.3 1.5 1 1 1 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Internalin_N PF12354.3 KII70249.1 - 0.067 12.8 0.0 0.23 11.0 0.0 1.9 1 0 0 1 1 1 0 Bacterial adhesion/invasion protein N terminal FLILHELTA PF10306.4 KII70251.1 - 0.035 14.1 1.1 0.088 12.8 0.1 2.0 2 0 0 2 2 2 0 Hypothetical protein FLILHELTA SAYSvFN PF10260.4 KII70251.1 - 0.083 12.6 3.0 0.51 10.1 0.0 3.1 4 0 0 4 4 4 0 Uncharacterized conserved domain (SAYSvFN) AAA_2 PF07724.9 KII70252.1 - 2.4e-29 102.4 0.0 2.8e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 KII70252.1 - 3.6e-07 30.0 0.0 4.5e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KII70252.1 - 0.0059 16.2 0.0 0.008 15.7 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DDE_3 PF13358.1 KII70253.1 - 1.2e-05 25.0 0.2 0.05 13.3 0.0 2.2 2 0 0 2 2 2 2 DDE superfamily endonuclease DUF3467 PF11950.3 KII70253.1 - 0.011 15.7 1.3 0.047 13.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3467) SNF2_N PF00176.18 KII70257.1 - 3.9e-21 75.1 0.0 7e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HDA2-3 PF11496.3 KII70257.1 - 2e-05 23.5 1.2 4.9e-05 22.2 0.8 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Fig1 PF12351.3 KII70259.1 - 0.085 12.7 0.6 0.12 12.2 0.4 1.1 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 C2 PF00168.25 KII70261.1 - 8.1e-13 48.0 0.1 1.2e-11 44.2 0.0 2.2 2 0 0 2 2 2 1 C2 domain FerI PF08151.7 KII70261.1 - 7.9e-08 32.2 0.0 1.4e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 FerI (NUC094) domain DUF3258 PF11646.3 KII70261.1 - 0.074 13.2 2.3 2.3 8.4 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function DUF3258 C2 PF00168.25 KII70262.1 - 0.0005 19.8 0.0 0.085 12.7 0.0 2.5 2 0 0 2 2 2 2 C2 domain C2 PF00168.25 KII70263.1 - 0.0046 16.7 0.0 0.014 15.1 0.0 1.8 2 0 0 2 2 2 1 C2 domain tRNA-synt_2 PF00152.15 KII70264.1 - 3.5e-84 282.4 0.2 4.3e-84 282.1 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KII70264.1 - 5.9e-10 38.8 0.3 2.3e-09 36.9 0.1 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 KII70264.1 - 8.9e-09 34.8 0.1 0.00053 19.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 KII70264.1 - 0.0037 16.8 0.1 1.9 8.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) Rad60-SLD PF11976.3 KII70266.1 - 1.9e-13 49.9 4.6 1.8e-06 27.4 0.5 2.3 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KII70266.1 - 2e-09 36.7 1.6 4e-07 29.3 0.1 2.4 3 0 0 3 3 3 2 Ubiquitin family YukD PF08817.5 KII70266.1 - 0.022 15.2 0.0 0.036 14.6 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD TUG-UBL1 PF11470.3 KII70266.1 - 0.079 12.8 0.0 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 GLUT4 regulating protein TUG BNR PF02012.15 KII70268.1 - 1.8e-06 26.8 4.2 0.29 11.1 0.1 4.2 5 0 0 5 5 5 3 BNR/Asp-box repeat Mo-co_dimer PF03404.11 KII70268.1 - 0.0045 16.6 0.2 1.4 8.5 0.0 3.2 2 1 1 3 3 3 1 Mo-co oxidoreductase dimerisation domain PSII_BNR PF14870.1 KII70268.1 - 0.046 12.6 1.5 0.63 8.9 0.5 2.4 2 1 1 3 3 3 0 Photosynthesis system II assembly factor YCF48 BNR PF02012.15 KII70269.1 - 0.00012 21.4 3.1 0.18 11.7 0.0 3.0 3 0 0 3 3 3 2 BNR/Asp-box repeat IcmL PF11393.3 KII70269.1 - 0.025 14.5 0.3 0.038 13.9 0.2 1.3 1 0 0 1 1 1 0 Macrophage killing protein with similarity to conjugation protein PurA PF04845.8 KII70270.1 - 1.4e-10 40.7 3.8 1.3e-06 27.6 0.1 2.7 1 1 2 3 3 3 3 PurA ssDNA and RNA-binding protein B12-binding_2 PF02607.12 KII70271.1 - 0.015 15.2 0.1 0.091 12.8 0.0 2.1 2 1 0 2 2 2 0 B12 binding domain DUF1436 PF07262.6 KII70271.1 - 0.023 14.1 0.7 0.038 13.4 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) Glyco_hydro_97 PF10566.4 KII70271.1 - 0.094 11.7 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycoside hydrolase 97 DDE_3 PF13358.1 KII70273.1 - 1.2e-08 34.8 0.0 2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Nop52 PF05997.7 KII70274.1 - 9.9e-34 116.6 5.9 1.5e-33 116.0 4.1 1.3 1 0 0 1 1 1 1 Nucleolar protein,Nop52 CRM1_C PF08767.6 KII70274.1 - 0.23 10.3 10.5 0.43 9.4 7.3 1.5 1 1 0 1 1 1 0 CRM1 C terminal HTH_29 PF13551.1 KII70275.1 - 5.1e-13 49.1 0.2 3.7e-12 46.3 0.0 2.2 1 1 1 2 2 2 1 Winged helix-turn helix DDE_3 PF13358.1 KII70275.1 - 1.9e-11 43.9 0.0 4e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.1 KII70275.1 - 1.1e-09 39.0 0.9 1.2e-06 29.2 0.0 2.9 3 0 0 3 3 3 2 Homeodomain-like domain HTH_28 PF13518.1 KII70275.1 - 3.8e-06 26.7 0.1 3.6e-05 23.6 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 KII70275.1 - 5.5e-06 25.8 0.0 4.7e-05 22.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.13 KII70275.1 - 0.00079 19.1 0.0 0.0021 17.7 0.0 1.7 1 1 0 1 1 1 1 'Paired box' domain Sigma70_r4_2 PF08281.7 KII70275.1 - 0.0013 18.1 0.0 0.0043 16.4 0.0 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_38 PF13936.1 KII70275.1 - 0.0088 15.5 0.1 0.17 11.4 0.0 2.8 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.1 KII70275.1 - 0.041 13.2 0.1 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_Tnp_ISL3 PF13542.1 KII70275.1 - 0.047 12.8 0.0 0.23 10.6 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_33 PF13592.1 KII70275.1 - 0.053 13.0 0.1 1.2 8.7 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn helix HTH_21 PF13276.1 KII70275.1 - 0.067 13.2 0.0 0.23 11.4 0.0 1.9 1 0 0 1 1 1 0 HTH-like domain HTH_40 PF14493.1 KII70275.1 - 0.075 13.2 0.3 0.23 11.7 0.0 2.2 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_29 PF13551.1 KII70276.1 - 1.8e-12 47.4 0.3 4e-11 43.0 0.0 2.2 1 1 1 2 2 2 2 Winged helix-turn helix DDE_3 PF13358.1 KII70276.1 - 2.4e-11 43.5 0.2 6.6e-11 42.1 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_32 PF13565.1 KII70276.1 - 3.7e-08 34.0 0.6 7.2e-06 26.7 0.0 2.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_33 PF13592.1 KII70276.1 - 9.7e-05 21.8 0.0 0.0002 20.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII70276.1 - 0.001 18.6 0.1 0.0063 16.1 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII70276.1 - 0.0018 18.2 0.7 0.0039 17.1 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain GHL6 PF14871.1 KII70276.1 - 0.0033 17.4 0.0 0.0055 16.7 0.0 1.4 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase 6 PAX PF00292.13 KII70276.1 - 0.0036 16.9 0.1 0.01 15.5 0.0 1.8 2 0 0 2 2 2 1 'Paired box' domain Sigma70_r4_2 PF08281.7 KII70276.1 - 0.065 12.7 0.0 0.33 10.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 MarR_2 PF12802.2 KII70276.1 - 0.092 12.4 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 MarR family Nop14 PF04147.7 KII70278.1 - 0.033 12.1 2.5 0.04 11.8 1.8 1.0 1 0 0 1 1 1 0 Nop14-like family PTS_EIIA_2 PF00359.17 KII70278.1 - 0.069 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 zf-H2C2_2 PF13465.1 KII70279.1 - 4e-15 55.2 18.3 8.9e-07 28.9 0.4 4.8 4 1 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 KII70279.1 - 5.6e-12 45.2 25.4 6.1e-07 29.4 2.0 6.0 6 0 0 6 6 6 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII70279.1 - 6e-09 35.6 16.5 0.0012 19.0 1.0 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KII70279.1 - 1.2e-07 31.3 18.1 0.0015 18.3 1.1 5.5 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII70279.1 - 1.1e-06 28.6 14.6 0.0081 16.2 1.2 5.7 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KII70279.1 - 0.00055 20.0 18.8 0.14 12.3 1.5 5.2 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 KII70279.1 - 0.001 19.1 4.3 1 9.5 0.1 4.1 1 1 3 4 4 4 1 C2H2 type zinc-finger (2 copies) Baculo_RING PF05883.6 KII70279.1 - 0.0042 16.9 0.3 0.0083 15.9 0.1 1.6 1 1 0 1 1 1 1 Baculovirus U-box/Ring-like domain Yippee-Mis18 PF03226.9 KII70279.1 - 0.019 15.0 0.4 0.046 13.7 0.3 1.6 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SET PF00856.23 KII70279.1 - 0.038 14.3 0.0 0.78 10.0 0.0 2.4 1 1 1 2 2 2 0 SET domain DiS_P_DiS PF06750.8 KII70279.1 - 0.086 12.6 0.4 0.18 11.5 0.3 1.6 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain DUF629 PF04780.7 KII70279.1 - 0.18 10.3 0.7 0.3 9.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF629) DUF1924 PF09086.6 KII70279.1 - 0.21 11.6 1.4 0.42 10.6 0.7 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF1924) C1_4 PF07975.7 KII70279.1 - 0.99 9.4 9.0 38 4.3 2.4 3.3 1 1 2 3 3 3 0 TFIIH C1-like domain zf-HIT PF04438.11 KII70279.1 - 1.8 8.3 5.7 2 8.1 0.1 3.1 3 0 0 3 3 3 0 HIT zinc finger PGM_PMM_IV PF00408.15 KII70280.1 - 1.5e-08 34.4 0.0 3.2e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.11 KII70280.1 - 3e-05 24.2 0.2 0.00017 21.9 0.0 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DEAD PF00270.24 KII70281.1 - 4.1e-45 153.2 0.1 5e-44 149.7 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII70281.1 - 6.7e-24 83.5 0.0 2.9e-23 81.5 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 KII70281.1 - 4.6e-05 22.3 0.0 0.0001 21.2 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain CS PF04969.11 KII70282.1 - 0.007 16.8 1.6 0.015 15.8 0.2 2.4 2 0 0 2 2 2 1 CS domain Kinesin PF00225.18 KII70283.1 - 1.1e-114 382.5 0.5 1.1e-114 382.5 0.3 2.7 3 0 0 3 3 3 1 Kinesin motor domain Lectin_N PF03954.9 KII70283.1 - 0.26 10.6 16.2 0.058 12.7 1.5 4.4 3 1 0 3 3 3 0 Hepatic lectin, N-terminal domain SLEI_Leptospira PF07620.6 KII70283.1 - 0.49 10.2 4.0 0.75 9.7 1.1 2.6 2 0 0 2 2 2 0 SLEI DUF948 PF06103.6 KII70283.1 - 1.4 8.7 15.4 1.9 8.3 0.1 5.8 5 1 0 6 6 6 0 Bacterial protein of unknown function (DUF948) UQ_con PF00179.21 KII70284.1 - 2.9e-49 166.1 0.6 3.5e-49 165.8 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KII70284.1 - 3.4e-05 23.5 0.0 7.7e-05 22.4 0.0 1.5 1 1 1 2 2 2 1 Prokaryotic E2 family B RWD PF05773.17 KII70284.1 - 0.002 17.9 0.0 0.003 17.4 0.0 1.4 1 0 0 1 1 1 1 RWD domain Complex1_30kDa PF00329.14 KII70285.1 - 1.5e-31 108.6 0.0 2.5e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit MCPsignal PF00015.16 KII70286.1 - 0.027 14.0 0.0 0.041 13.4 0.0 1.4 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CLTH PF10607.4 KII70286.1 - 0.046 13.4 0.2 0.058 13.0 0.2 1.1 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DX PF01666.12 KII70286.1 - 0.12 12.8 0.2 0.12 12.8 0.2 1.7 2 0 0 2 2 2 0 DX module MEF2_binding PF09047.5 KII70287.1 - 0.023 14.3 0.5 0.048 13.2 0.3 1.6 1 0 0 1 1 1 0 MEF2 binding DUF350 PF03994.9 KII70287.1 - 0.027 14.1 0.0 0.049 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF350) Bax1-I PF01027.15 KII70288.1 - 3e-16 59.6 24.2 3.4e-16 59.4 16.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF308 PF03729.8 KII70288.1 - 0.041 13.8 8.1 0.041 13.8 5.6 2.7 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) DUF3784 PF12650.2 KII70288.1 - 9.9 6.1 23.0 0.46 10.4 6.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) YmgB PF10798.3 KII70289.1 - 2.3e-27 94.5 5.3 2.9e-25 87.8 2.2 2.5 2 1 0 2 2 2 2 Biofilm development protein YmgB/AriR RVT_1 PF00078.22 KII70298.1 - 6.8e-19 68.0 0.1 1.7e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII70299.1 - 2.8e-11 43.5 0.0 1.2e-10 41.5 0.0 1.9 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS1595 PF12762.2 KII70302.1 - 4.6e-09 36.2 0.0 4.8e-09 36.2 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII70303.1 - 4.8e-08 32.8 0.0 7.5e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII70306.1 - 0.097 11.7 0.1 0.19 10.8 0.0 1.6 1 1 1 2 2 2 0 DDE superfamily endonuclease DUF1014 PF06244.7 KII70307.1 - 1.3e-16 60.8 0.3 1.7e-16 60.5 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1014) YABBY PF04690.8 KII70307.1 - 0.002 18.3 0.0 0.0022 18.2 0.0 1.2 1 0 0 1 1 1 1 YABBY protein DUF2611 PF11022.3 KII70307.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2611) EF-hand_7 PF13499.1 KII70308.1 - 1.2e-06 28.5 4.7 0.0014 18.6 3.3 2.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KII70308.1 - 2.1e-06 26.5 7.6 0.016 14.4 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KII70308.1 - 3.9e-06 26.3 2.2 0.3 11.0 0.7 3.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KII70308.1 - 0.00016 20.8 3.3 0.12 11.8 0.3 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KII70308.1 - 0.0014 18.2 3.8 2 8.0 0.1 3.7 3 1 0 3 3 3 2 EF-hand domain pair Pentapeptide_3 PF13576.1 KII70311.1 - 0.037 13.9 1.7 0.037 13.9 1.2 2.0 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) SUKH-3 PF14433.1 KII70311.1 - 0.071 12.8 0.1 0.27 11.0 0.0 2.0 2 0 0 2 2 2 0 SUKH-3 immunity protein LemA PF04011.7 KII70312.1 - 0.0044 16.1 0.1 0.008 15.3 0.0 1.4 1 0 0 1 1 1 1 LemA family DDE_3 PF13358.1 KII70314.1 - 1.9e-16 60.1 0.0 2.3e-16 59.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF89 PF01937.14 KII70314.1 - 0.06 12.1 0.1 0.071 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF89 DUF1491 PF07372.7 KII70315.1 - 0.074 12.9 0.0 0.097 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) CBFD_NFYB_HMF PF00808.18 KII70316.1 - 8.9e-08 32.0 0.1 3.6e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Choline_kinase PF01633.15 KII70317.1 - 0.014 15.0 0.1 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase gag-asp_proteas PF13975.1 KII70317.1 - 0.033 14.0 0.1 0.065 13.0 0.1 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII70317.1 - 0.047 13.6 0.3 0.11 12.4 0.2 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease INTS5_N PF14837.1 KII70317.1 - 0.062 12.6 0.2 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus FG-GAP PF01839.18 KII70319.1 - 1.4e-09 37.3 3.4 0.00045 19.8 0.0 2.6 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.1 KII70319.1 - 2.5e-08 34.1 0.9 7.5e-08 32.6 0.6 1.9 1 0 0 1 1 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella HATPase_c_3 PF13589.1 KII70326.1 - 1.4e-14 53.9 0.1 2.5e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KII70326.1 - 1.1e-09 37.9 0.2 2.4e-09 36.8 0.1 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1241 PF06840.6 KII70326.1 - 0.023 13.9 1.3 5.2 6.3 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1241) MutL_C PF08676.6 KII70327.1 - 5.3e-24 84.4 0.1 7.8e-23 80.6 0.0 2.3 1 1 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 KII70327.1 - 0.00039 19.8 0.0 0.00087 18.7 0.0 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain RhoGEF PF00621.15 KII70332.1 - 5.2e-29 101.3 4.1 7.5e-29 100.8 2.8 1.2 1 0 0 1 1 1 1 RhoGEF domain rve PF00665.21 KII70334.1 - 2.6e-19 69.4 0.0 3.9e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70334.1 - 0.00043 19.7 0.0 0.00081 18.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DUF4158 PF13700.1 KII70336.1 - 0.0013 18.2 0.4 0.0017 17.8 0.2 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4158) DUF1871 PF08958.5 KII70336.1 - 0.022 14.8 0.0 0.053 13.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1871) rve PF00665.21 KII70337.1 - 2e-17 63.4 0.1 2.5e-17 63.0 0.1 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70337.1 - 0.0091 15.4 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Tricho_coat PF05892.6 KII70337.1 - 0.076 12.2 0.2 0.09 11.9 0.1 1.1 1 0 0 1 1 1 0 Trichovirus coat protein Asp_protease PF09668.5 KII70339.1 - 0.00011 21.8 0.1 0.00018 21.0 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII70339.1 - 0.00097 19.0 0.1 0.0018 18.1 0.1 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.6 KII70339.1 - 0.012 15.4 0.2 0.024 14.5 0.2 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.18 KII70339.1 - 0.016 15.1 0.9 0.039 13.8 0.6 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII70339.1 - 2.4 7.8 7.9 1.9 8.2 0.4 2.6 2 0 0 2 2 2 0 Zinc knuckle WASH-7_N PF14745.1 KII70340.1 - 0.039 12.1 0.0 0.053 11.7 0.0 1.3 1 0 0 1 1 1 0 WASH complex subunit 7, N-terminal GTP_EFTU PF00009.22 KII70345.1 - 4.6e-33 114.2 0.0 6.2e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 KII70345.1 - 1.2e-10 41.2 0.2 2.1e-10 40.5 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 2 DAO PF01266.19 KII70347.1 - 1.4e-12 47.1 0.0 1.9e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase CHU_C PF13585.1 KII70347.1 - 0.025 14.4 0.2 0.12 12.3 0.1 2.1 2 0 0 2 2 2 0 C-terminal domain of CHU protein family GPP34 PF05719.6 KII70349.1 - 7.7e-35 120.8 0.0 9.9e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) HMG_box PF00505.14 KII70351.1 - 4.8e-18 65.1 1.9 5.4e-18 65.0 0.5 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KII70351.1 - 2.8e-06 27.6 0.2 7.2e-06 26.2 0.1 1.6 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.7 KII70351.1 - 0.072 12.7 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 CHDNT (NUC034) domain WD40 PF00400.27 KII70352.1 - 9.6e-08 31.6 2.2 1.2e-05 25.0 0.3 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat HhH-GPD PF00730.20 KII70353.1 - 4.1e-12 46.3 0.0 9.4e-12 45.1 0.0 1.8 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 KII70353.1 - 0.00036 20.0 0.0 0.00086 18.8 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.2 KII70353.1 - 0.088 12.7 0.1 0.75 9.7 0.0 2.5 3 1 0 3 3 3 0 Helix-hairpin-helix motif FLYWCH PF04500.11 KII70354.1 - 1.2e-07 31.4 2.3 1.8e-07 30.9 1.6 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain zf-primase PF09329.6 KII70355.1 - 0.00019 20.9 0.7 0.00096 18.7 0.3 2.1 2 0 0 2 2 2 1 Primase zinc finger Homeobox PF00046.24 KII70357.1 - 1.1e-16 60.2 8.2 1.8e-16 59.4 5.7 1.4 1 0 0 1 1 1 1 Homeobox domain PDCD9 PF07147.7 KII70358.1 - 0.002 17.0 0.7 0.36 9.5 0.1 2.1 2 0 0 2 2 2 2 Mitochondrial 28S ribosomal protein S30 (PDCD9) DUF159 PF02586.9 KII70359.1 - 2.5e-39 134.9 0.0 3.2e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, COG2135 HSP70 PF00012.15 KII70360.1 - 6.5e-254 843.3 5.9 7.4e-254 843.2 4.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KII70360.1 - 1.2e-14 53.6 0.4 1.1e-13 50.4 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 KII70360.1 - 0.0039 16.8 0.0 0.0074 15.9 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 KII70360.1 - 0.004 16.9 3.2 3.7 7.4 0.0 3.9 3 1 0 3 3 3 1 Cell division protein FtsA DDR PF08841.5 KII70360.1 - 0.0091 14.8 0.3 0.1 11.4 0.0 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain PilM_2 PF11104.3 KII70360.1 - 0.06 12.2 0.0 0.61 8.9 0.0 2.1 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; Inhibitor_I29 PF08246.7 KII70361.1 - 4e-08 33.3 1.6 6.4e-08 32.7 1.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.18 KII70361.1 - 0.0028 17.5 0.0 0.0058 16.5 0.0 1.5 1 0 0 1 1 1 1 Papain family cysteine protease DUF694 PF05107.7 KII70361.1 - 0.0031 16.7 0.1 0.0038 16.5 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF694) STIL_N PF15253.1 KII70361.1 - 0.045 12.4 0.0 0.067 11.8 0.0 1.2 1 0 0 1 1 1 0 SCL-interrupting locus protein N-terminus SCO1-SenC PF02630.9 KII70362.1 - 1.8e-36 125.3 0.1 2.6e-36 124.8 0.1 1.2 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.1 KII70362.1 - 0.012 15.6 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like IMPDH PF00478.20 KII70363.1 - 5.9e-98 327.9 3.5 7e-98 327.7 2.4 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 KII70363.1 - 1.3e-09 37.3 0.5 1.9e-09 36.8 0.3 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.10 KII70363.1 - 2.1e-07 30.4 0.5 2.7e-07 30.0 0.3 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase CBS PF00571.23 KII70363.1 - 4.5e-07 29.5 0.0 1.2e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 CBS domain His_biosynth PF00977.16 KII70363.1 - 4.9e-05 22.7 2.2 1.9 7.7 0.1 2.3 1 1 0 1 1 1 1 Histidine biosynthesis protein NanE PF04131.9 KII70363.1 - 0.00016 20.7 0.4 0.00026 20.0 0.2 1.3 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.9 KII70363.1 - 0.00096 18.2 1.7 0.0027 16.8 1.1 2.0 1 1 0 1 1 1 1 Thiazole biosynthesis protein ThiG Dus PF01207.12 KII70363.1 - 0.0048 15.7 1.9 0.063 12.0 0.1 2.1 1 1 0 2 2 2 1 Dihydrouridine synthase (Dus) PcrB PF01884.12 KII70363.1 - 0.0099 15.1 2.6 0.073 12.3 0.2 2.7 2 1 1 3 3 3 1 PcrB family DUF561 PF04481.7 KII70363.1 - 0.026 13.4 1.5 0.052 12.4 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF561) IGPS PF00218.16 KII70363.1 - 0.045 12.8 0.2 0.61 9.0 0.0 2.2 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase TMP-TENI PF02581.12 KII70363.1 - 0.045 12.8 1.7 0.18 10.9 0.5 2.3 2 1 1 3 3 3 0 Thiamine monophosphate synthase/TENI DHO_dh PF01180.16 KII70363.1 - 0.26 10.1 4.8 0.7 8.7 0.4 2.4 2 1 1 3 3 3 0 Dihydroorotate dehydrogenase IMPDH PF00478.20 KII70364.1 - 7.6e-27 94.1 0.0 8.5e-27 93.9 0.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 KII70364.1 - 0.025 13.7 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase SNAP PF14938.1 KII70366.1 - 1.3e-06 27.7 0.2 1.9e-06 27.2 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Homeobox PF00046.24 KII70367.1 - 1.2e-17 63.2 5.5 1.9e-17 62.5 3.8 1.3 1 0 0 1 1 1 1 Homeobox domain BrkDBD PF09607.5 KII70367.1 - 0.076 12.5 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Brinker DNA-binding domain CWC25 PF12542.3 KII70369.1 - 6.9e-16 58.4 0.1 6.9e-16 58.4 0.1 2.9 3 0 0 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.4 KII70369.1 - 1.3e-11 44.2 8.6 1.3e-11 44.2 6.0 3.0 3 0 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR E1-E2_ATPase PF00122.15 KII70370.1 - 3.2e-55 186.6 1.0 5.4e-55 185.9 0.7 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 KII70370.1 - 9.7e-38 129.5 9.1 1e-37 129.4 2.3 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KII70370.1 - 2.1e-29 103.4 0.0 5.4e-28 98.8 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII70370.1 - 2.8e-22 78.4 0.1 7.1e-22 77.1 0.1 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 KII70370.1 - 1.7e-14 54.4 0.2 9.6e-14 51.9 0.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KII70370.1 - 5.3e-07 29.4 1.4 8.5e-06 25.5 0.4 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3027 PF11228.3 KII70371.1 - 0.04 13.5 0.1 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) KTI12 PF08433.5 KII70372.1 - 1.6e-50 171.8 0.1 1.9e-50 171.6 0.1 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 KII70372.1 - 7.6e-06 25.8 0.0 1.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII70372.1 - 0.00036 21.3 0.0 0.0039 18.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KII70372.1 - 0.00088 19.5 0.1 0.0023 18.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.15 KII70372.1 - 0.0052 16.4 0.0 0.033 13.8 0.0 2.1 1 1 0 1 1 1 1 Adenylylsulphate kinase MMR_HSR1 PF01926.18 KII70372.1 - 0.0091 15.9 0.1 0.018 14.9 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Zeta_toxin PF06414.7 KII70372.1 - 0.02 13.9 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 KII70372.1 - 0.033 14.0 0.1 0.056 13.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.13 KII70372.1 - 0.047 12.7 0.0 0.11 11.5 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_22 PF13401.1 KII70372.1 - 0.08 13.0 0.0 0.39 10.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain HMG_box PF00505.14 KII70373.1 - 3e-20 72.2 1.7 3e-20 72.2 1.2 2.3 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KII70373.1 - 1.1e-07 32.0 0.3 1.1e-07 32.0 0.2 2.4 1 1 1 2 2 2 1 HMG-box domain MAT_Alpha1 PF04769.7 KII70373.1 - 0.0065 15.8 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 RNase_HII PF01351.13 KII70375.1 - 1.3e-39 135.8 0.0 1.7e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII DDE_Tnp_IS1595 PF12762.2 KII70376.1 - 7.2e-22 77.8 0.0 1e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain zf-MIZ PF02891.15 KII70377.1 - 2.3e-12 46.1 7.9 4.3e-12 45.3 5.5 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 KII70377.1 - 2.6e-05 23.6 3.1 6.1e-05 22.4 2.2 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit End_tail_spike PF12219.3 KII70377.1 - 0.0023 17.7 0.0 0.0042 16.9 0.0 1.3 1 0 0 1 1 1 1 Catalytic domain of bacteriophage endosialidase zf-RING_UBOX PF13445.1 KII70377.1 - 0.027 14.1 1.8 0.027 14.1 1.2 2.9 3 0 0 3 3 3 0 RING-type zinc-finger zf-RING_2 PF13639.1 KII70377.1 - 3.9 7.3 8.4 8.2 6.3 5.8 1.6 1 0 0 1 1 1 0 Ring finger domain SCO1-SenC PF02630.9 KII70378.1 - 6.2e-46 156.1 0.5 8.3e-46 155.7 0.3 1.1 1 0 0 1 1 1 1 SCO1/SenC MIF4G_like_2 PF09090.6 KII70380.1 - 3e-18 65.9 3.4 6.6e-18 64.8 2.3 1.6 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.6 KII70380.1 - 7.7e-13 48.3 0.7 2e-12 46.9 0.5 1.8 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.14 KII70380.1 - 9.6e-12 44.7 4.8 9.6e-12 44.7 3.3 2.7 2 1 0 2 2 2 1 MIF4G domain FliG_N PF14842.1 KII70380.1 - 0.0048 17.0 0.1 0.018 15.1 0.1 2.0 1 0 0 1 1 1 1 FliG N-terminal domain W2 PF02020.13 KII70380.1 - 0.31 10.9 2.8 0.46 10.4 0.1 2.8 3 0 0 3 3 3 0 eIF4-gamma/eIF5/eIF2-epsilon UFD1 PF03152.9 KII70381.1 - 5.8e-43 146.0 0.0 7.8e-43 145.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 HTH_Tnp_Tc3_2 PF01498.13 KII70382.1 - 0.00034 20.6 0.2 0.0006 19.8 0.1 1.3 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII70382.1 - 0.001 19.7 0.1 0.0015 19.2 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 KII70382.1 - 0.057 13.5 0.1 0.073 13.2 0.0 1.1 1 0 0 1 1 1 0 Winged helix-turn helix IBR PF01485.16 KII70383.1 - 3.4e-15 55.6 22.5 7.2e-11 41.7 6.3 4.0 4 1 0 4 4 4 2 IBR domain zf-RING_5 PF14634.1 KII70383.1 - 0.00028 20.5 11.5 0.00028 20.5 8.0 4.1 3 1 1 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.1 KII70383.1 - 0.00031 20.4 12.8 0.00031 20.4 8.9 3.6 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.1 KII70383.1 - 0.0012 18.7 13.8 0.0012 18.7 9.6 3.9 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) PAP2_3 PF14378.1 KII70383.1 - 0.0069 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 PAP2 superfamily PFU PF09070.6 KII70384.1 - 2.7e-27 95.1 0.2 5.9e-27 93.9 0.1 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.27 KII70384.1 - 6.3e-24 82.9 13.3 3.4e-06 26.7 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat PUL PF08324.6 KII70384.1 - 2e-06 26.8 3.2 3e-06 26.2 2.2 1.3 1 0 0 1 1 1 1 PUL domain DUF2215 PF10225.4 KII70385.1 - 1e-14 54.6 0.0 1.4e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2215) Cys_rich_CPCC PF14206.1 KII70385.1 - 0.029 13.9 0.1 0.24 10.9 0.1 2.1 2 0 0 2 2 2 0 Cysteine-rich CPCC DUF1451 PF07295.6 KII70385.1 - 0.33 10.7 3.5 0.62 9.8 2.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1451) RRM_1 PF00076.17 KII70386.1 - 1.6e-11 43.6 0.0 3e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII70386.1 - 7.9e-11 41.7 0.0 3.7e-10 39.6 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII70386.1 - 6.6e-06 25.8 0.1 1.6e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.6 KII70386.1 - 0.0015 18.0 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) RNA_bind PF08675.6 KII70386.1 - 0.0091 15.9 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 RNA binding domain RRM_3 PF08777.6 KII70386.1 - 0.019 14.7 0.1 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif Coprogen_oxidas PF01218.13 KII70387.1 - 3e-115 383.8 0.0 3.5e-115 383.6 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Mre11_DNA_bind PF04152.9 KII70388.1 - 1.8e-05 24.7 0.8 5.2e-05 23.1 0.6 1.8 1 1 0 1 1 1 1 Mre11 DNA-binding presumed domain ATP_Ca_trans_C PF12424.3 KII70389.1 - 0.13 12.6 0.1 0.6 10.5 0.0 2.0 2 0 0 2 2 2 0 Plasma membrane calcium transporter ATPase C terminal DDE_1 PF03184.14 KII70390.1 - 8.3e-28 97.0 0.5 1e-27 96.7 0.3 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Homeobox PF00046.24 KII70392.1 - 1.4e-18 66.2 1.8 3.4e-18 65.0 1.3 1.7 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KII70392.1 - 0.0029 17.2 0.1 0.0029 17.2 0.0 3.1 4 1 0 4 4 4 1 Homeobox KN domain MRP-63 PF14978.1 KII70392.1 - 0.014 15.7 0.1 0.035 14.5 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ribosome protein 63 RRF PF01765.14 KII70392.1 - 0.016 14.6 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Ribosome recycling factor MAT1 PF06391.8 KII70393.1 - 8.1e-27 94.1 9.8 1.1e-26 93.7 6.8 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-RING_5 PF14634.1 KII70393.1 - 0.026 14.2 5.7 0.047 13.4 4.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.20 KII70393.1 - 1.1 9.0 6.5 2.2 7.9 4.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Spt4 PF06093.8 KII70393.1 - 1.9 8.3 0.0 1.9 8.3 0.0 2.5 2 1 0 2 2 2 0 Spt4/RpoE2 zinc finger zf-C3HC4_2 PF13923.1 KII70393.1 - 2.3 8.2 7.9 4.4 7.4 5.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KII70393.1 - 2.8 7.9 6.4 0.52 10.2 1.7 1.8 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Sec6 PF06046.8 KII70395.1 - 1e-51 175.7 2.4 1e-51 175.7 1.7 1.6 2 0 0 2 2 2 1 Exocyst complex component Sec6 DUF4413 PF14372.1 KII70395.1 - 0.06 13.3 1.0 0.81 9.7 0.0 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4413) STE PF02200.11 KII70395.1 - 0.16 12.0 2.5 10 6.3 0.0 3.3 3 1 0 3 3 3 0 STE like transcription factor MutS_III PF05192.13 KII70395.1 - 0.36 10.5 5.5 4.4 7.0 3.0 3.1 2 1 0 2 2 2 0 MutS domain III MCPsignal PF00015.16 KII70395.1 - 7.1 6.1 10.4 0.31 10.5 0.2 3.1 3 1 1 4 4 4 0 Methyl-accepting chemotaxis protein (MCP) signalling domain zf-CCHC_4 PF14392.1 KII70397.1 - 0.0051 16.4 1.0 0.0051 16.4 0.7 3.5 2 1 1 3 3 3 2 Zinc knuckle Gag_p24 PF00607.15 KII70397.1 - 0.0078 15.7 0.0 0.02 14.4 0.0 1.6 2 0 0 2 2 2 1 gag gene protein p24 (core nucleocapsid protein) PNMA PF14893.1 KII70397.1 - 0.069 12.1 0.0 0.26 10.2 0.0 1.7 2 0 0 2 2 2 0 PNMA Retrotrans_gag PF03732.12 KII70398.1 - 4e-07 30.0 0.0 0.0027 17.7 0.0 2.3 2 0 0 2 2 2 2 Retrotransposon gag protein zf-CCHC_4 PF14392.1 KII70398.1 - 0.0014 18.2 9.7 0.2 11.3 0.5 2.8 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC PF00098.18 KII70398.1 - 0.066 13.1 12.0 0.55 10.2 2.1 2.4 2 0 0 2 2 2 0 Zinc knuckle DUF3677 PF12432.3 KII70400.1 - 0.0022 18.4 0.0 0.014 15.8 0.0 2.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3677) SNAP PF14938.1 KII70403.1 - 0.018 14.1 4.8 0.044 12.9 3.3 1.8 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP Arm PF00514.18 KII70404.1 - 4.7e-15 54.7 4.8 0.092 12.6 0.0 7.8 8 0 0 8 8 8 6 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KII70404.1 - 0.022 15.2 0.0 3.6 8.1 0.0 4.0 3 2 1 4 4 4 0 HEAT-like repeat DDE_1 PF03184.14 KII70405.1 - 0.0092 15.1 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Thioredoxin PF00085.15 KII70407.1 - 1.9e-14 53.1 0.2 9.6e-12 44.5 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_8 PF13905.1 KII70407.1 - 0.018 15.1 3.1 5.6 7.1 0.0 3.8 2 2 2 4 4 4 0 Thioredoxin-like DUF4371 PF14291.1 KII70408.1 - 0.0028 17.2 0.0 0.0031 17.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) LtrA PF06772.6 KII70410.1 - 0.0058 15.5 0.3 0.0061 15.5 0.2 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) TMEM247 PF15444.1 KII70410.1 - 0.018 14.8 0.9 0.02 14.7 0.7 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 BNR PF02012.15 KII70411.1 - 1.7e-05 23.9 2.3 0.048 13.4 0.0 3.9 5 0 0 5 5 5 2 BNR/Asp-box repeat Collagen PF01391.13 KII70412.1 - 8.9e-30 102.0 110.3 1.2e-09 37.5 20.5 4.1 2 2 2 4 4 4 4 Collagen triple helix repeat (20 copies) Gal_Lectin PF02140.13 KII70412.1 - 1.4e-28 98.9 10.7 3.2e-15 56.1 1.3 2.2 2 0 0 2 2 2 2 Galactose binding lectin domain Fer4_15 PF13459.1 KII70412.1 - 0.78 10.3 5.7 3.3 8.3 0.9 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain Collagen PF01391.13 KII70413.1 - 5.8e-17 60.9 58.8 9.7e-10 37.8 20.4 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Gal_Lectin PF02140.13 KII70413.1 - 2e-13 50.4 2.6 2.9e-13 49.9 1.8 1.3 1 0 0 1 1 1 1 Galactose binding lectin domain Cornifin PF02389.10 KII70414.1 - 1.4e-15 57.5 29.5 1.1e-09 38.3 5.1 2.6 1 1 2 3 3 3 3 Cornifin (SPRR) family Fibrinogen_BP PF08017.6 KII70414.1 - 0.0001 20.7 28.3 0.00015 20.1 19.6 1.2 1 0 0 1 1 1 1 Fibrinogen binding protein MAGP PF05507.6 KII70415.1 - 0.089 12.6 0.4 0.1 12.3 0.3 1.2 1 0 0 1 1 1 0 Microfibril-associated glycoprotein (MAGP) Dynamin_N PF00350.18 KII70417.1 - 1.4e-11 44.5 0.0 2.6e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KII70417.1 - 0.00067 19.6 0.4 0.0013 18.7 0.1 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.11 KII70417.1 - 0.0023 17.0 0.1 0.0037 16.3 0.1 1.3 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.8 KII70417.1 - 0.032 13.0 0.2 0.05 12.4 0.1 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.22 KII70417.1 - 0.098 12.9 0.3 0.22 11.7 0.1 1.6 1 1 1 2 2 2 0 ABC transporter Disintegrin PF00200.18 KII70418.1 - 4.2e-11 42.9 12.3 4.2e-11 42.9 8.5 3.5 2 1 1 3 3 3 1 Disintegrin ADAM_CR PF08516.7 KII70418.1 - 3.3e-09 36.8 7.5 3.3e-09 36.8 5.2 3.4 3 1 0 3 3 3 1 ADAM cysteine-rich LSM PF01423.17 KII70419.1 - 1.5e-14 53.2 0.1 2.2e-14 52.7 0.1 1.3 1 0 0 1 1 1 1 LSM domain DUF4604 PF15377.1 KII70420.1 - 0.00055 20.1 18.6 0.01 16.0 12.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4604) DUF3357 PF11837.3 KII70420.1 - 0.089 12.6 0.3 0.11 12.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) 2-oxoacid_dh PF00198.18 KII70421.1 - 3.1e-77 258.9 0.0 4.1e-77 258.5 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 KII70421.1 - 4.5e-16 58.2 0.0 1.3e-15 56.7 0.0 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.12 KII70421.1 - 3.8e-15 55.2 0.0 6.8e-15 54.4 0.0 1.4 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 KII70421.1 - 0.027 14.1 0.0 0.26 10.9 0.0 2.3 2 0 0 2 2 2 0 Biotin-lipoyl like GCV_H PF01597.14 KII70421.1 - 0.13 11.9 0.3 0.37 10.4 0.0 1.8 2 0 0 2 2 2 0 Glycine cleavage H-protein HCNGP PF07818.8 KII70424.1 - 4.4e-16 58.6 0.1 7.3e-16 57.9 0.1 1.2 1 0 0 1 1 1 1 HCNGP-like protein DUF1447 PF07288.6 KII70424.1 - 0.039 13.7 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1447) RVP PF00077.15 KII70429.1 - 1.5e-05 24.8 0.0 3.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII70429.1 - 0.091 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease HTH_Tnp_Tc5 PF03221.11 KII70431.1 - 5e-06 26.2 0.1 8.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain SieB PF14163.1 KII70432.1 - 0.054 13.0 0.0 0.072 12.6 0.0 1.1 1 0 0 1 1 1 0 Superinfection exclusion protein B HemY_N PF07219.8 KII70432.1 - 0.06 12.9 0.2 0.079 12.5 0.1 1.1 1 0 0 1 1 1 0 HemY protein N-terminus PetM PF08041.6 KII70432.1 - 0.064 12.7 0.7 0.11 11.9 0.5 1.3 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Baculo_11_kDa PF06143.6 KII70432.1 - 0.091 12.1 1.1 0.13 11.6 0.8 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family ODV-E18 PF10717.4 KII70432.1 - 0.22 10.9 3.1 0.35 10.3 2.0 1.3 1 1 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 rve PF00665.21 KII70434.1 - 3e-24 85.4 0.0 5.8e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70434.1 - 0.0034 16.8 0.0 0.013 14.9 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII70434.1 - 0.0073 16.2 0.3 0.03 14.2 0.0 2.0 2 0 0 2 2 2 1 DDE domain Transcript_VP30 PF11507.3 KII70434.1 - 0.086 12.6 0.0 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 Ebola virus-specific transcription factor VP30 CcmH PF03918.9 KII70435.1 - 0.12 11.3 0.5 0.17 10.8 0.3 1.4 1 1 0 1 1 1 0 Cytochrome C biogenesis protein Protocadherin PF08374.6 KII70438.1 - 0.005 16.5 0.0 0.0054 16.3 0.0 1.1 1 0 0 1 1 1 1 Protocadherin SKG6 PF08693.5 KII70441.1 - 0.11 11.8 4.3 0.17 11.2 3.0 1.2 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MLANA PF14991.1 KII70441.1 - 0.13 12.2 0.2 0.17 11.8 0.2 1.4 1 1 0 1 1 1 0 Protein melan-A Homeobox_KN PF05920.6 KII70443.1 - 8.3e-12 44.6 0.4 1.7e-11 43.6 0.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 KII70443.1 - 8.9e-09 34.8 2.8 1.7e-08 33.9 2.0 1.5 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.3 KII70443.1 - 0.071 12.1 0.6 0.2 10.7 0.0 2.0 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez HA PF03457.9 KII70443.1 - 0.13 12.3 0.2 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Helicase associated domain SOUL PF04832.7 KII70444.1 - 4.5e-40 137.0 0.1 5.6e-40 136.7 0.1 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein Mac-1 PF09028.5 KII70444.1 - 0.048 12.4 0.3 0.052 12.3 0.2 1.1 1 0 0 1 1 1 0 Mac 1 Arg_repressor PF01316.16 KII70445.1 - 0.014 14.9 1.2 0.021 14.3 0.8 1.2 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_Tnp_Tc3_2 PF01498.13 KII70445.1 - 0.06 13.4 0.1 0.13 12.3 0.0 1.5 2 0 0 2 2 2 0 Transposase Myb_DNA-binding PF00249.26 KII70446.1 - 6.5e-43 144.5 9.5 3.5e-15 55.7 0.1 3.7 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KII70446.1 - 9.6e-34 115.2 9.1 5e-14 52.1 0.1 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 KII70446.1 - 0.001 19.1 8.7 0.38 10.9 0.4 3.7 3 1 0 3 3 3 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 KII70446.1 - 0.16 11.9 9.6 17 5.3 0.1 4.4 3 2 1 4 4 4 0 Myb/SANT-like DNA-binding domain DUF4085 PF13315.1 KII70446.1 - 0.41 9.9 3.0 4.3 6.6 0.2 2.9 1 1 3 4 4 4 0 Protein of unknown function (DUF4085) FLYWCH PF04500.11 KII70448.1 - 2.7e-11 43.1 3.7 4.7e-11 42.4 1.9 1.9 2 0 0 2 2 2 1 FLYWCH zinc finger domain MULE PF10551.4 KII70448.1 - 5.5e-11 42.4 0.0 1.7e-10 40.9 0.0 1.8 1 0 0 1 1 1 1 MULE transposase domain G-patch PF01585.18 KII70449.1 - 5.4e-15 54.8 2.8 8.1e-15 54.3 0.6 2.1 2 0 0 2 2 2 1 G-patch domain Ank PF00023.25 KII70449.1 - 8.8e-05 22.1 0.1 0.00019 21.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 KII70449.1 - 0.00014 21.7 0.0 0.00051 20.0 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.2 KII70449.1 - 0.00089 19.5 0.0 0.0017 18.6 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) G-patch_2 PF12656.2 KII70449.1 - 0.0027 17.5 0.2 0.0081 15.9 0.1 1.8 1 0 0 1 1 1 1 DExH-box splicing factor binding site Ank_4 PF13637.1 KII70449.1 - 0.0076 16.7 0.0 0.019 15.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII70449.1 - 0.055 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) PSII_BNR PF14870.1 KII70451.1 - 0.0099 14.8 0.0 0.025 13.6 0.0 1.7 2 0 0 2 2 2 1 Photosynthesis system II assembly factor YCF48 BNR PF02012.15 KII70451.1 - 0.13 12.1 11.1 1.3 9.1 0.1 4.9 5 0 0 5 5 5 0 BNR/Asp-box repeat Annexin PF00191.15 KII70452.1 - 3e-06 27.0 0.9 0.0067 16.3 0.1 2.7 2 0 0 2 2 2 2 Annexin DUF1474 PF07342.6 KII70452.1 - 0.36 11.0 2.8 0.19 12.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) Rifin_STEVOR PF02009.11 KII70453.1 - 0.002 17.8 0.0 0.002 17.8 0.0 1.1 1 0 0 1 1 1 1 Rifin/stevor family DUF4448 PF14610.1 KII70453.1 - 0.0021 17.5 0.0 0.0027 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF912 PF06024.7 KII70453.1 - 0.0079 16.2 0.1 0.011 15.8 0.1 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) TMEM154 PF15102.1 KII70453.1 - 0.026 14.2 0.1 0.031 13.9 0.1 1.1 1 0 0 1 1 1 0 TMEM154 protein family DUF2951 PF11166.3 KII70453.1 - 0.026 14.3 0.2 0.036 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF3169 PF11368.3 KII70453.1 - 0.044 12.9 0.1 0.055 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Protocadherin PF08374.6 KII70453.1 - 0.059 13.0 0.1 0.07 12.7 0.1 1.2 1 0 0 1 1 1 0 Protocadherin Col_cuticle_N PF01484.12 KII70453.1 - 0.072 12.7 1.6 0.2 11.3 1.1 1.8 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain EphA2_TM PF14575.1 KII70453.1 - 0.48 10.8 2.8 0.95 9.9 1.9 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DDE_3 PF13358.1 KII70458.1 - 2.7e-08 33.6 0.1 0.0027 17.4 0.0 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease YukC PF10140.4 KII70459.1 - 0.0007 18.2 0.6 0.00098 17.7 0.4 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Vma12 PF11712.3 KII70459.1 - 0.00072 19.2 0.4 0.0012 18.5 0.3 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase CD34_antigen PF06365.7 KII70459.1 - 0.0016 18.1 0.1 0.0019 17.8 0.1 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF4366 PF14283.1 KII70459.1 - 0.0036 16.7 0.5 0.0049 16.3 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) DUF912 PF06024.7 KII70459.1 - 0.0062 16.5 0.1 0.0096 15.9 0.1 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3899 PF13038.1 KII70459.1 - 0.0096 16.0 0.2 0.0096 16.0 0.1 1.7 2 0 0 2 2 1 1 Domain of unknown function (DUF3899) RNA_pol_3_Rpc31 PF11705.3 KII70459.1 - 0.01 15.8 7.0 0.012 15.6 4.9 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2207 PF09972.4 KII70459.1 - 0.017 13.6 0.9 0.025 13.1 0.3 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) PUL PF08324.6 KII70459.1 - 0.04 12.7 1.0 0.055 12.2 0.7 1.2 1 0 0 1 1 1 0 PUL domain Herpes_gE PF02480.11 KII70459.1 - 0.049 11.8 0.0 0.064 11.5 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF4199 PF13858.1 KII70459.1 - 0.049 13.5 0.3 0.1 12.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) ETRAMP PF09716.5 KII70459.1 - 0.072 13.0 0.4 0.14 12.1 0.2 1.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PBP1_TM PF14812.1 KII70459.1 - 0.073 13.3 1.8 0.11 12.8 1.2 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4337 PF14235.1 KII70459.1 - 0.15 11.9 1.8 0.23 11.2 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) PEX11 PF05648.9 KII70459.1 - 0.2 10.8 0.9 0.29 10.3 0.6 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Med17 PF10156.4 KII70459.1 - 0.21 9.7 6.2 0.29 9.3 4.3 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex PA26 PF04636.8 KII70459.1 - 0.23 10.0 3.0 0.27 9.8 2.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Bap31 PF05529.7 KII70459.1 - 0.56 9.6 5.1 0.61 9.5 1.9 2.0 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like DUF2457 PF10446.4 KII70459.1 - 0.71 8.5 10.0 0.85 8.2 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF1266 PF06889.6 KII70459.1 - 0.84 9.4 4.6 0.35 10.6 1.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) YqfQ PF14181.1 KII70459.1 - 5.5 7.0 10.0 7.8 6.5 7.0 1.1 1 0 0 1 1 1 0 YqfQ-like protein Ldl_recept_a PF00057.13 KII70460.1 - 1.5e-29 101.6 45.7 6.1e-12 45.2 7.7 3.0 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII70461.1 - 3.7e-23 81.1 44.8 1.6e-12 47.0 8.4 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A ADAM_CR PF08516.7 KII70461.1 - 2.8 8.0 24.7 0.31 11.0 1.7 3.1 1 1 2 3 3 3 0 ADAM cysteine-rich MULE PF10551.4 KII70464.1 - 6.4e-06 26.2 0.0 2e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.12 KII70464.1 - 0.093 12.2 0.0 0.22 11.0 0.0 1.6 1 1 0 1 1 1 0 Transposase DUF1955 PF09205.5 KII70464.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) rve PF00665.21 KII70465.1 - 2.2e-26 92.3 0.1 1.2e-25 89.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII70465.1 - 3e-24 85.5 0.0 5.8e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII70465.1 - 1.5e-07 31.2 0.0 3.5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII70465.1 - 0.00015 21.2 0.0 0.0004 19.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.1 KII70465.1 - 0.013 15.9 0.0 0.04 14.4 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease POX PF07526.6 KII70467.1 - 0.041 14.1 0.0 0.051 13.8 0.0 1.2 1 0 0 1 1 1 0 Associated with HOX Bromodomain PF00439.20 KII70467.1 - 0.29 11.0 2.5 0.37 10.7 0.3 2.1 2 1 1 3 3 3 0 Bromodomain Pox_A21 PF05323.7 KII70467.1 - 0.7 10.3 3.8 30 5.0 0.1 2.8 3 0 0 3 3 3 0 Poxvirus A21 Protein TMF_TATA_bd PF12325.3 KII70468.1 - 0.0076 15.9 3.6 0.034 13.8 0.2 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF4094 PF13334.1 KII70468.1 - 0.015 15.7 0.3 0.036 14.4 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) UPF0547 PF10571.4 KII70468.1 - 0.048 13.3 0.1 0.089 12.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 DUF2553 PF10830.3 KII70468.1 - 0.088 13.3 0.6 0.18 12.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2553) HMA PF00403.21 KII70468.1 - 0.22 11.7 1.0 1.4 9.1 0.0 2.3 2 1 0 2 2 2 0 Heavy-metal-associated domain Spc24 PF08286.6 KII70468.1 - 4 7.1 9.1 3.1 7.5 0.9 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Phage_GP20 PF06810.6 KII70468.1 - 4.9 6.5 9.6 1.1 8.7 1.3 2.4 1 1 0 2 2 2 0 Phage minor structural protein GP20 Allexi_40kDa PF05549.6 KII70469.1 - 1.4 8.1 9.5 1.6 7.9 0.1 3.1 3 0 0 3 3 3 0 Allexivirus 40kDa protein Spore_III_AB PF09548.5 KII70470.1 - 0.036 13.8 0.4 0.1 12.3 0.3 1.8 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Rapamycin_bind PF08771.6 KII70470.1 - 0.045 13.8 0.4 0.14 12.3 0.2 1.9 2 0 0 2 2 2 0 Rapamycin binding domain DUF3960 PF13142.1 KII70471.1 - 0.14 11.9 0.4 4.6 7.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3960) IBN_N PF03810.14 KII70472.1 - 0.045 13.6 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 Importin-beta N-terminal domain HAUS-augmin3 PF14932.1 KII70473.1 - 0.0093 15.1 0.1 0.014 14.6 0.1 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 Creatinase_N PF01321.13 KII70473.1 - 0.12 12.8 0.0 0.42 11.0 0.0 1.8 1 1 0 1 1 1 0 Creatinase/Prolidase N-terminal domain Sulfotransfer_1 PF00685.22 KII70474.1 - 0.018 14.2 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain APOC4 PF15119.1 KII70474.1 - 0.061 13.3 0.0 0.087 12.8 0.0 1.2 1 0 0 1 1 1 0 Apolipoprotein C4 CheR PF01739.13 KII70474.1 - 0.092 12.0 3.6 1.8 7.8 0.3 2.0 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Rhabdo_ncap_2 PF03216.8 KII70474.1 - 0.11 11.1 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleoprotein Big_2 PF02368.13 KII70475.1 - 3.4 7.6 5.7 1.4 8.8 0.1 3.1 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 2) RRM_3 PF08777.6 KII70477.1 - 1e-07 31.7 0.2 1e-07 31.7 0.1 2.9 2 1 1 3 3 3 1 RNA binding motif La PF05383.12 KII70477.1 - 0.0028 17.4 0.2 0.02 14.6 0.0 2.3 2 0 0 2 2 2 1 La domain RRM_1 PF00076.17 KII70477.1 - 0.0088 15.6 0.4 2.8 7.6 0.0 3.6 3 1 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII70477.1 - 0.015 15.2 0.0 1.2 9.1 0.0 3.2 2 1 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Cofilin_ADF PF00241.15 KII70477.1 - 0.13 12.1 3.4 0.23 11.3 0.3 2.3 2 0 0 2 2 2 0 Cofilin/tropomyosin-type actin-binding protein Sugar_tr PF00083.19 KII70478.1 - 2.8e-23 82.2 19.6 4.5e-18 65.0 4.1 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 KII70478.1 - 9.5e-17 60.7 15.7 9.5e-17 60.7 10.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1189 PF06691.6 KII70478.1 - 0.022 14.0 0.9 0.062 12.6 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) DUF4044 PF13253.1 KII70478.1 - 6.3 6.0 6.6 0.55 9.4 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) SNAP PF14938.1 KII70479.1 - 1e-06 28.0 0.9 1.5e-06 27.5 0.6 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII70479.1 - 0.028 14.0 0.7 0.11 12.1 0.0 2.3 2 1 1 3 3 3 0 TPR repeat MIT PF04212.13 KII70479.1 - 0.05 13.4 0.1 3.4 7.6 0.2 2.6 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain RVT_1 PF00078.22 KII70484.1 - 2.6e-23 82.5 0.0 4.4e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.1 KII70484.1 - 0.013 16.0 0.0 0.024 15.1 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.15 KII70484.1 - 0.057 13.3 0.1 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease DDE_3 PF13358.1 KII70490.1 - 5.7e-05 22.8 0.6 0.00016 21.4 0.4 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF3199 PF11436.3 KII70492.1 - 0.056 13.2 0.7 0.3 10.9 0.1 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3199) rve_2 PF13333.1 KII70492.1 - 0.095 12.7 0.7 14 5.8 0.1 3.2 2 1 1 3 3 3 0 Integrase core domain HTH_32 PF13565.1 KII70493.1 - 1.5e-06 28.8 0.0 2.1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 KII70493.1 - 0.0043 17.1 0.0 0.0057 16.7 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_33 PF13592.1 KII70493.1 - 0.0044 16.5 0.0 0.0084 15.6 0.0 1.5 2 0 0 2 2 2 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII70493.1 - 0.024 14.6 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 Transposase Rep_3 PF01051.16 KII70493.1 - 0.036 13.6 0.0 0.038 13.6 0.0 1.1 1 0 0 1 1 1 0 Initiator Replication protein DEK_C PF08766.6 KII70493.1 - 0.096 12.4 0.3 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 DEK C terminal domain DDE_3 PF13358.1 KII70494.1 - 1.8e-16 60.2 0.0 2.9e-16 59.5 0.0 1.3 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII70496.1 - 0.0017 18.1 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease PAX PF00292.13 KII70496.1 - 0.015 14.9 0.4 0.027 14.1 0.3 1.4 1 0 0 1 1 1 0 'Paired box' domain DUF1323 PF07037.6 KII70496.1 - 0.066 13.3 0.2 0.12 12.6 0.1 1.6 2 0 0 2 2 2 0 Putative transcription regulator (DUF1323) Snf7 PF03357.16 KII70497.1 - 2.2e-09 36.9 6.2 2.8e-09 36.5 4.3 1.1 1 0 0 1 1 1 1 Snf7 Terminase_1 PF03354.10 KII70497.1 - 0.014 13.8 1.6 0.017 13.5 1.1 1.1 1 0 0 1 1 1 0 Phage Terminase Syntaxin_2 PF14523.1 KII70497.1 - 0.024 14.6 1.5 1.9 8.5 0.3 2.3 2 0 0 2 2 2 0 Syntaxin-like protein SurA_N PF09312.6 KII70497.1 - 0.19 11.6 1.7 2 8.2 0.1 2.4 1 1 2 3 3 3 0 SurA N-terminal domain YlbD_coat PF14071.1 KII70497.1 - 0.68 10.0 4.1 1.4 8.9 1.7 2.0 1 1 1 2 2 2 0 Putative coat protein DDE_1 PF03184.14 KII70500.1 - 2.9e-24 85.4 0.2 6.5e-23 81.0 0.1 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII70500.1 - 0.00097 18.9 0.5 0.0018 18.0 0.1 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease ATP-cone PF03477.11 KII70500.1 - 0.43 11.0 4.1 7.3 7.0 1.8 2.6 2 1 0 2 2 2 0 ATP cone domain RGS-like PF09128.6 KII70502.1 - 0.047 13.1 0.0 0.073 12.5 0.0 1.3 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Cnd1 PF12717.2 KII70506.1 - 0.028 14.2 3.0 0.075 12.8 1.8 1.7 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 FlaC_arch PF05377.6 KII70506.1 - 0.054 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Laminin_I PF06008.9 KII70506.1 - 0.079 12.2 0.1 0.1 11.8 0.1 1.1 1 0 0 1 1 1 0 Laminin Domain I DUF3883 PF13020.1 KII70507.1 - 1e-12 47.6 0.1 1.9e-12 46.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) Serpin PF00079.15 KII70508.1 - 2.8e-38 132.0 0.2 5.7e-38 131.0 0.0 1.4 1 1 1 2 2 2 1 Serpin (serine protease inhibitor) Ribosomal_S13 PF00416.17 KII70509.1 - 0.15 12.5 2.6 0.35 11.3 1.0 2.2 1 1 1 2 2 2 0 Ribosomal protein S13/S18 YfbU PF03887.9 KII70514.1 - 0.033 13.7 0.5 0.033 13.7 0.4 1.9 2 1 0 2 2 2 0 YfbU domain Reo_sigmaC PF04582.7 KII70514.1 - 2.7 7.1 12.9 2.4 7.2 2.2 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Clathrin PF00637.15 KII70515.1 - 2.3e-06 27.2 0.1 4.5e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 Region in Clathrin and VPS DDE_3 PF13358.1 KII70515.1 - 7e-06 25.8 0.0 0.00012 21.8 0.0 2.3 1 1 1 2 2 2 1 DDE superfamily endonuclease AAA PF00004.24 KII70516.1 - 6.8e-11 42.4 0.0 8.8e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 KII70516.1 - 0.037 13.9 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA PF00004.24 KII70517.1 - 3.4e-08 33.7 0.0 5.2e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KII70517.1 - 6.1e-06 27.0 0.0 8.6e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII70517.1 - 0.00039 20.1 0.1 0.00055 19.6 0.1 1.3 1 0 0 1 1 1 1 Part of AAA domain Viral_helicase1 PF01443.13 KII70517.1 - 0.00043 19.8 0.0 0.00065 19.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase cobW PF02492.14 KII70517.1 - 0.0031 16.9 0.0 0.004 16.6 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 KII70517.1 - 0.0042 17.3 0.0 0.0061 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KII70517.1 - 0.0047 16.8 0.0 0.0063 16.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII70517.1 - 0.0051 16.8 0.0 0.0064 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.22 KII70517.1 - 0.011 16.0 0.0 0.061 13.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.1 KII70517.1 - 0.011 15.8 0.1 0.019 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KII70517.1 - 0.018 14.8 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 KII70517.1 - 0.024 13.8 1.3 0.1 11.7 0.1 2.1 2 1 1 3 3 3 0 Chromatin associated protein KTI12 NTPase_1 PF03266.10 KII70517.1 - 0.037 13.7 0.8 0.06 13.0 0.4 1.5 1 1 0 1 1 1 0 NTPase ADK PF00406.17 KII70517.1 - 0.051 13.4 0.0 0.12 12.2 0.0 1.6 2 0 0 2 2 2 0 Adenylate kinase AAA_29 PF13555.1 KII70517.1 - 0.053 13.0 0.0 0.085 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cytidylate_kin2 PF13189.1 KII70517.1 - 0.062 13.2 0.0 0.082 12.8 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase-like family DUF2075 PF09848.4 KII70517.1 - 0.063 12.2 0.0 0.083 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 KII70517.1 - 0.073 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 KII70517.1 - 0.095 11.5 0.0 0.099 11.5 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 KII70517.1 - 0.095 11.7 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 KII70517.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KII70517.1 - 0.13 11.6 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 KII70517.1 - 0.13 11.0 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 ArgK protein ApoC-I PF04691.7 KII70517.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) DDE_Tnp_IS1595 PF12762.2 KII70518.1 - 0.021 14.6 0.1 0.18 11.6 0.1 2.0 1 1 0 1 1 1 0 ISXO2-like transposase domain DUF3081 PF11280.3 KII70520.1 - 0.11 12.0 0.4 0.36 10.3 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3081) BNR PF02012.15 KII70520.1 - 0.12 12.2 0.1 0.12 12.2 0.0 3.0 3 0 0 3 3 3 0 BNR/Asp-box repeat DDE_3 PF13358.1 KII70521.1 - 0.0026 17.5 0.0 0.97 9.1 0.0 2.5 2 1 1 3 3 3 2 DDE superfamily endonuclease Glycos_transf_1 PF00534.15 KII70522.1 - 0.0064 15.9 0.0 0.0073 15.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 rve PF00665.21 KII70524.1 - 9.6e-27 93.4 0.0 2.1e-26 92.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70524.1 - 6e-05 22.4 0.0 0.00015 21.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII70525.1 - 3.6e-25 88.5 0.0 9.2e-25 87.2 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII70525.1 - 8.5e-06 25.6 0.0 1.9e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII70525.1 - 9.8e-05 21.9 0.0 0.00032 20.2 0.0 1.8 1 1 0 1 1 1 1 Aspartyl protease UBN2 PF14223.1 KII70525.1 - 0.00032 20.4 0.1 0.0028 17.4 0.0 2.6 2 1 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.18 KII70525.1 - 0.018 14.9 2.2 0.018 14.9 1.5 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 KII70525.1 - 0.34 10.6 16.9 0.29 10.9 0.9 2.7 2 1 1 3 3 3 0 Zinc knuckle DDE_Tnp_IS1595 PF12762.2 KII70528.1 - 5e-10 39.4 0.8 6.2e-09 35.8 0.6 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain Pox_F11 PF04943.7 KII70529.1 - 0.021 13.7 0.2 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 Poxvirus F11 protein MULE PF10551.4 KII70530.1 - 2.4e-08 34.0 2.0 8.6e-07 29.0 0.2 2.9 2 1 1 3 3 3 1 MULE transposase domain H_lectin PF09458.5 KII70530.1 - 0.013 15.0 0.2 0.037 13.6 0.1 1.7 1 0 0 1 1 1 0 H-type lectin domain Annexin PF00191.15 KII70533.1 - 3.3e-18 65.3 3.5 2.5e-06 27.2 0.0 4.4 5 0 0 5 5 5 3 Annexin AKAP95 PF04988.7 KII70533.1 - 0.04 13.7 2.7 0.32 10.7 0.5 2.3 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) RhoGAP PF00620.22 KII70535.1 - 1.9e-12 47.0 0.0 5.4e-12 45.5 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain RhoGAP PF00620.22 KII70536.1 - 7.9e-10 38.5 0.2 1.7e-09 37.4 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain START PF01852.14 KII70536.1 - 1e-05 24.9 0.0 0.00027 20.3 0.0 2.6 2 1 0 2 2 2 1 START domain 14-3-3 PF00244.15 KII70537.1 - 1.6e-64 217.2 0.4 1.9e-64 217.0 0.3 1.0 1 0 0 1 1 1 1 14-3-3 protein 14-3-3 PF00244.15 KII70538.1 - 1.1e-39 135.8 8.2 1.3e-39 135.7 5.7 1.0 1 0 0 1 1 1 1 14-3-3 protein Pep3_Vps18 PF05131.9 KII70538.1 - 0.0062 15.9 1.4 0.022 14.2 0.4 2.1 1 1 1 2 2 2 1 Pep3/Vps18/deep orange family DUF3692 PF12469.3 KII70538.1 - 0.065 13.4 0.0 0.098 12.8 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein DUF830 PF05708.7 KII70538.1 - 0.089 12.7 0.3 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 Orthopoxvirus protein of unknown function (DUF830) DDE_Tnp_IS1595 PF12762.2 KII70539.1 - 1.6e-21 76.7 0.0 2e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII70540.1 - 4.3e-22 78.5 0.1 7.2e-22 77.8 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain zf-C2H2 PF00096.21 KII70540.1 - 0.12 12.7 0.4 0.25 11.7 0.3 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type Sedlin_N PF04628.8 KII70541.1 - 1.1e-21 77.0 1.7 1.3e-21 76.8 1.1 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 KII70541.1 - 0.001 18.7 0.2 0.0018 18.0 0.2 1.6 1 1 0 1 1 1 1 Sybindin-like family Phage_rep_O PF04492.8 KII70541.1 - 0.12 12.6 0.0 0.38 10.9 0.0 1.8 1 1 1 2 2 2 0 Bacteriophage replication protein O DDE_3 PF13358.1 KII70542.1 - 0.0003 20.5 0.0 0.00075 19.2 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF4336 PF14234.1 KII70542.1 - 0.0057 15.8 0.0 0.007 15.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4336) HTH_DeoR PF08220.7 KII70542.1 - 0.091 12.3 0.5 0.14 11.7 0.3 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain DUF3965 PF13112.1 KII70543.1 - 0.012 14.8 0.3 0.014 14.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3965) ClpS PF02617.12 KII70545.1 - 0.14 11.9 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS NapB PF03892.9 KII70546.1 - 0.11 12.1 0.6 0.57 9.8 0.4 1.8 1 1 1 2 2 2 0 Nitrate reductase cytochrome c-type subunit (NapB) DUF2358 PF10184.4 KII70548.1 - 0.41 10.5 3.2 5.4 6.9 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2358) ABC_tran PF00005.22 KII70549.1 - 4.2e-47 159.8 3.6 7.9e-25 87.7 0.0 3.7 3 1 1 4 4 3 2 ABC transporter AAA_21 PF13304.1 KII70549.1 - 3.8e-19 69.7 11.5 3e-06 27.3 0.0 5.0 4 1 1 5 5 4 4 AAA domain SMC_N PF02463.14 KII70549.1 - 4.6e-12 45.6 5.2 0.00014 21.1 0.0 4.4 4 1 0 4 4 3 3 RecF/RecN/SMC N terminal domain MobB PF03205.9 KII70549.1 - 6.8e-08 32.3 0.2 0.00098 18.8 0.0 2.7 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 KII70549.1 - 1.5e-07 31.6 0.8 0.024 14.7 0.0 3.4 3 1 0 3 3 2 2 AAA domain AAA_29 PF13555.1 KII70549.1 - 1.7e-07 30.6 0.1 0.00097 18.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 KII70549.1 - 3.2e-07 29.6 0.1 0.0015 17.7 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 KII70549.1 - 7.1e-07 29.3 0.5 0.013 15.5 0.0 3.1 3 0 0 3 3 2 2 AAA ATPase domain AAA_33 PF13671.1 KII70549.1 - 8e-07 29.0 0.0 0.0061 16.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 KII70549.1 - 9.6e-07 29.3 0.2 0.032 14.7 0.0 3.4 3 0 0 3 3 2 2 Miro-like protein AAA_17 PF13207.1 KII70549.1 - 3.3e-06 27.8 9.3 0.01 16.6 0.0 3.9 4 1 0 4 4 2 2 AAA domain AAA_14 PF13173.1 KII70549.1 - 3.4e-06 26.9 0.1 0.15 11.9 0.0 3.3 3 0 0 3 3 2 2 AAA domain NACHT PF05729.7 KII70549.1 - 5e-06 26.2 0.1 0.074 12.6 0.0 2.6 2 0 0 2 2 2 2 NACHT domain ABC_tran_2 PF12848.2 KII70549.1 - 7.3e-06 25.7 8.0 7.3e-06 25.7 5.6 4.3 3 1 1 4 4 3 1 ABC transporter AAA PF00004.24 KII70549.1 - 8e-06 26.0 3.9 0.046 13.9 0.0 3.5 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.18 KII70549.1 - 1.4e-05 24.9 0.0 0.0099 15.8 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Arch_ATPase PF01637.13 KII70549.1 - 1.4e-05 24.8 1.7 0.23 11.1 0.0 3.7 3 0 0 3 3 3 2 Archaeal ATPase RNA_helicase PF00910.17 KII70549.1 - 3.7e-05 23.8 0.0 0.15 12.2 0.0 3.1 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.1 KII70549.1 - 4e-05 23.1 0.1 0.2 11.0 0.0 3.3 4 0 0 4 4 3 2 AAA domain NTPase_1 PF03266.10 KII70549.1 - 0.00012 21.8 0.4 0.45 10.2 0.1 3.3 3 0 0 3 3 3 2 NTPase SRP54 PF00448.17 KII70549.1 - 0.00013 21.4 0.2 0.023 14.1 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_28 PF13521.1 KII70549.1 - 0.00014 21.8 0.0 0.75 9.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 KII70549.1 - 0.00015 21.5 0.1 0.12 12.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 KII70549.1 - 0.00025 20.6 0.1 0.34 10.2 0.0 2.8 3 0 0 3 3 3 2 AAA-like domain NB-ARC PF00931.17 KII70549.1 - 0.00045 19.1 1.9 0.1 11.4 0.0 2.8 3 0 0 3 3 2 2 NB-ARC domain SbcCD_C PF13558.1 KII70549.1 - 0.00067 19.5 0.1 0.23 11.3 0.1 3.6 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ATP-synt_ab PF00006.20 KII70549.1 - 0.0018 17.8 0.1 0.081 12.4 0.0 2.4 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.1 KII70549.1 - 0.0025 17.5 0.3 0.74 9.6 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA_18 PF13238.1 KII70549.1 - 0.0038 17.5 9.2 0.21 11.8 0.0 4.7 5 1 1 6 6 5 1 AAA domain ArgK PF03308.11 KII70549.1 - 0.0039 16.0 0.2 0.41 9.3 0.0 2.5 2 0 0 2 2 2 1 ArgK protein cobW PF02492.14 KII70549.1 - 0.004 16.6 1.7 0.4 10.1 0.0 2.8 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.1 KII70549.1 - 0.008 15.7 8.5 0.34 10.4 0.0 3.7 4 0 0 4 4 4 2 AAA domain PduV-EutP PF10662.4 KII70549.1 - 0.015 14.7 0.1 2.7 7.4 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.12 KII70549.1 - 0.018 14.4 0.4 9.3 5.6 0.0 3.0 3 0 0 3 3 2 0 IstB-like ATP binding protein RuvB_N PF05496.7 KII70549.1 - 0.048 12.6 0.1 8.6 5.3 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus DUF87 PF01935.12 KII70549.1 - 0.057 13.2 0.0 0.057 13.2 0.0 4.3 4 1 1 5 5 5 0 Domain of unknown function DUF87 AAA_23 PF13476.1 KII70549.1 - 0.088 13.1 0.1 0.088 13.1 0.0 4.7 5 0 0 5 5 3 0 AAA domain TGT PF01702.13 KII70550.1 - 5e-63 212.5 0.1 5.7e-63 212.3 0.1 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase TGT PF01702.13 KII70551.1 - 1.3e-06 27.8 0.0 2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase PV_NSP1 PF12433.3 KII70552.1 - 0.091 12.8 0.6 0.21 11.6 0.4 1.6 1 0 0 1 1 1 0 Parvovirus non-structural protein 1 PV_NSP1 PF12433.3 KII70553.1 - 0.091 12.8 0.6 0.21 11.6 0.4 1.6 1 0 0 1 1 1 0 Parvovirus non-structural protein 1 PLAC8 PF04749.12 KII70554.1 - 1e-16 61.3 8.4 1.3e-16 61.0 5.8 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4218 PF13960.1 KII70554.1 - 0.12 11.7 1.0 0.25 10.7 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4218) DUF781 PF05612.7 KII70555.1 - 0.004 15.8 1.1 0.0047 15.6 0.8 1.2 1 0 0 1 1 1 1 Mouse protein of unknown function (DUF781) SnoaL_2 PF12680.2 KII70556.1 - 4.5e-17 62.3 0.0 5.4e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.15 KII70556.1 - 1.9e-08 34.7 0.0 2.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL PF07366.7 KII70556.1 - 9e-08 31.7 0.0 1.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase LEH PF07858.7 KII70556.1 - 0.0014 18.6 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 Limonene-1,2-epoxide hydrolase catalytic domain SnoaL_3 PF13474.1 KII70556.1 - 0.013 15.5 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain SnoaL_4 PF13577.1 KII70556.1 - 0.065 13.1 0.0 0.087 12.7 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain DUF4440 PF14534.1 KII70556.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Porin_1 PF00267.16 KII70557.1 - 2.5e-77 260.4 13.9 2.8e-77 260.2 9.6 1.0 1 0 0 1 1 1 1 Gram-negative porin Glyco_hydro_1 PF00232.13 KII70558.1 - 1.3e-128 429.0 2.4 1.5e-128 428.8 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.13 KII70558.1 - 0.00029 20.1 0.1 0.00045 19.5 0.1 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PTS_EIIC PF02378.13 KII70559.1 - 3.9e-18 65.3 29.5 3.9e-18 65.3 20.4 2.1 1 1 1 2 2 2 1 Phosphotransferase system, EIIC CemA PF03040.9 KII70559.1 - 0.8 9.2 3.7 0.19 11.2 0.2 1.7 2 0 0 2 2 2 0 CemA family DUF3687 PF12459.3 KII70564.1 - 0.73 9.1 5.6 0.24 10.6 1.9 1.7 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein vATP-synt_AC39 PF01992.11 KII70565.1 - 0.03 13.4 0.3 0.055 12.5 0.2 1.4 1 0 0 1 1 1 0 ATP synthase (C/AC39) subunit Phage_connect_1 PF05135.8 KII70567.1 - 0.2 11.8 1.9 0.27 11.4 1.3 1.3 1 1 0 1 1 1 0 Phage gp6-like head-tail connector protein rve_3 PF13683.1 KII70570.1 - 7.7e-06 25.3 0.0 1.2e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve PF00665.21 KII70570.1 - 7.3e-05 22.8 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF725 PF05267.7 KII70570.1 - 0.015 15.1 0.0 0.017 14.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF725) Asp_protease_2 PF13650.1 KII70572.1 - 3.8e-08 33.7 0.0 4.9e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII70572.1 - 9.1e-05 22.2 0.0 0.00013 21.6 0.0 1.1 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII70572.1 - 0.0095 15.8 0.0 0.013 15.3 0.0 1.4 1 1 0 1 1 1 1 Retroviral aspartyl protease UxuA PF03786.8 KII70573.1 - 0.083 11.4 0.1 0.12 10.9 0.1 1.4 1 1 0 1 1 1 0 D-mannonate dehydratase (UxuA) SLIDE PF09111.5 KII70574.1 - 0.7 9.6 4.4 8.8 6.0 0.7 2.5 2 1 0 2 2 2 0 SLIDE Kazal_1 PF00050.16 KII70575.1 - 0.22 11.5 5.5 9.1 6.3 1.4 2.6 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.10 KII70575.1 - 0.59 10.1 3.1 31 4.6 1.3 2.7 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain Snf7 PF03357.16 KII70578.1 - 8.5e-25 87.0 13.1 1e-24 86.8 9.1 1.1 1 0 0 1 1 1 1 Snf7 ApoLp-III PF07464.6 KII70578.1 - 0.049 13.6 0.7 0.049 13.6 0.5 2.7 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF342 PF03961.8 KII70578.1 - 0.064 11.6 7.8 0.24 9.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) DUF479 PF04336.7 KII70578.1 - 0.11 12.6 2.4 2.6 8.1 0.3 3.2 3 1 1 4 4 4 0 Protein of unknown function, DUF479 DUF4298 PF14131.1 KII70578.1 - 0.26 11.1 7.1 0.79 9.6 0.1 3.3 2 2 1 4 4 4 0 Domain of unknown function (DUF4298) Vac_Fusion PF02346.11 KII70578.1 - 0.31 10.5 2.7 1 8.8 0.2 2.7 3 0 0 3 3 3 0 Chordopoxvirus fusion protein TraF_2 PF13729.1 KII70578.1 - 0.57 8.9 6.2 0.23 10.2 1.4 2.1 1 1 1 2 2 2 0 F plasmid transfer operon, TraF, protein DASH_Dam1 PF08653.5 KII70578.1 - 0.69 9.7 6.9 31 4.4 0.1 3.5 3 0 0 3 3 3 0 DASH complex subunit Dam1 Helicase_IV_N PF12462.3 KII70578.1 - 0.78 9.3 4.9 0.37 10.4 0.8 2.2 1 1 0 2 2 2 0 DNA helicase IV / RNA helicase N terminal DUF29 PF01724.11 KII70578.1 - 1.4 8.7 13.9 3.5 7.4 1.0 3.0 1 1 1 3 3 3 0 Domain of unknown function DUF29 DUF4375 PF14300.1 KII70578.1 - 1.5 8.8 5.6 0.79 9.7 0.4 2.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4375) DASH_Dad3 PF08656.5 KII70578.1 - 1.5 8.5 8.9 6.5 6.5 0.6 3.3 3 1 0 3 3 3 0 DASH complex subunit Dad3 Herpes_UL25 PF01499.11 KII70578.1 - 1.6 6.9 10.1 0.17 10.1 1.7 2.0 1 1 1 2 2 2 0 Herpesvirus UL25 family Rotamase PF00639.16 KII70578.1 - 1.7 9.4 5.9 16 6.3 0.1 3.0 2 1 1 3 3 3 0 PPIC-type PPIASE domain DUF883 PF05957.8 KII70578.1 - 1.8 8.9 9.1 3.2 8.2 2.1 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF2203 PF09969.4 KII70578.1 - 2.9 8.1 7.8 78 3.5 5.4 2.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) MutS_III PF05192.13 KII70578.1 - 3.8 7.2 8.0 8.2 6.1 5.5 1.7 1 1 0 1 1 1 0 MutS domain III DUF3571 PF12095.3 KII70578.1 - 4.9 7.4 9.8 0.54 10.5 0.6 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF3571) HSP70 PF00012.15 KII70578.1 - 6.6 4.5 9.8 7.8 4.2 6.8 1.2 1 0 0 1 1 1 0 Hsp70 protein EXOSC1 PF10447.4 KII70584.1 - 0.0014 18.5 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 2 Exosome component EXOSC1/CSL4 S1 PF00575.18 KII70584.1 - 0.031 14.3 0.1 0.088 12.9 0.0 1.8 1 0 0 1 1 1 0 S1 RNA binding domain ECR1_N PF14382.1 KII70584.1 - 0.061 12.6 0.0 0.84 8.9 0.0 2.2 2 0 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region tRNA_anti-codon PF01336.20 KII70584.1 - 0.14 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain SART-1 PF03343.8 KII70586.1 - 1.5e-12 46.7 6.1 1.5e-12 46.7 4.2 2.1 1 1 0 2 2 2 1 SART-1 family CAF-1_p150 PF11600.3 KII70586.1 - 8.3 5.7 26.8 0.15 11.3 5.7 2.4 3 0 0 3 3 3 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Ank PF00023.25 KII70587.1 - 1.7e-19 68.5 0.5 1.9e-08 33.6 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 KII70587.1 - 8.1e-18 64.5 0.0 1.5e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KII70587.1 - 1.2e-16 60.6 0.1 3.6e-06 27.3 0.0 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII70587.1 - 2.2e-16 59.5 0.6 1.9e-08 34.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII70587.1 - 5e-14 51.0 0.1 3.1e-06 26.9 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Sec62 PF03839.11 KII70588.1 - 1.9e-35 122.3 3.3 1.9e-35 122.3 2.3 1.4 1 1 0 1 1 1 1 Translocation protein Sec62 DUF2371 PF10177.4 KII70588.1 - 1.4 8.7 3.7 6.9 6.5 1.7 2.4 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) DNA_pol3_delta2 PF13177.1 KII70589.1 - 9e-08 31.9 0.3 1.1e-07 31.6 0.2 1.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 KII70589.1 - 0.037 14.1 0.0 0.056 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 KII70589.1 - 0.07 13.3 0.9 0.17 12.0 0.6 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 KII70589.1 - 0.095 12.7 0.2 0.29 11.1 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Solute_trans_a PF03619.11 KII70590.1 - 1.2e-36 126.4 17.3 1.5e-36 126.1 12.0 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha S4 PF01479.20 KII70591.1 - 4.5e-10 38.7 0.0 8.2e-10 37.9 0.0 1.4 1 0 0 1 1 1 1 S4 domain IBR PF01485.16 KII70593.1 - 1.5e-15 56.8 25.3 9e-12 44.6 6.4 4.1 3 1 0 3 3 3 2 IBR domain zf-C3HC4 PF00097.20 KII70593.1 - 0.0018 17.8 11.3 0.0018 17.8 7.8 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) HATPase_c_3 PF13589.1 KII70595.1 - 8.6e-17 61.0 0.2 2.8e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KII70595.1 - 1.2e-05 24.9 0.0 2.4e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1664 PF07889.7 KII70596.1 - 0.0053 16.5 2.2 0.0053 16.5 1.5 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) BAR PF03114.13 KII70596.1 - 0.012 15.1 6.9 0.024 14.1 4.8 1.4 1 0 0 1 1 1 0 BAR domain Syntaxin-6_N PF09177.6 KII70596.1 - 0.026 14.9 2.9 0.026 14.9 2.0 2.9 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF1788 PF08747.6 KII70596.1 - 0.067 13.0 2.3 0.12 12.1 1.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1788) Reo_sigmaC PF04582.7 KII70596.1 - 0.13 11.4 2.3 0.19 10.8 1.6 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.4 KII70596.1 - 0.21 11.4 17.6 0.95 9.3 12.1 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.7 KII70596.1 - 0.55 10.6 7.6 0.32 11.4 1.5 2.9 2 1 1 3 3 3 0 SlyX Nsp1_C PF05064.8 KII70596.1 - 0.94 9.1 6.4 0.83 9.3 1.5 2.5 2 0 0 2 2 2 0 Nsp1-like C-terminal region IncA PF04156.9 KII70596.1 - 1.3 8.6 15.6 0.34 10.4 5.9 2.2 1 1 0 2 2 2 0 IncA protein DUF745 PF05335.8 KII70596.1 - 1.5 8.2 4.6 3.5 7.1 2.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF948 PF06103.6 KII70596.1 - 1.9 8.3 5.6 25 4.8 2.6 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.4 KII70596.1 - 2 8.6 9.6 3.8 7.7 0.4 2.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec20 PF03908.8 KII70596.1 - 4.8 6.9 6.5 29 4.4 0.1 3.4 2 1 1 3 3 3 0 Sec20 NPV_P10 PF05531.7 KII70596.1 - 9.8 6.5 7.7 6.1 7.1 0.6 3.0 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF724 PF05266.9 KII70596.1 - 10 5.7 11.5 3.1 7.3 4.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) GIIM PF08388.6 KII70597.1 - 0.038 13.7 0.1 0.097 12.4 0.1 1.7 1 0 0 1 1 1 0 Group II intron, maturase-specific domain DUF4007 PF13182.1 KII70599.1 - 3.3e-70 236.1 0.0 7.3e-70 235.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4007) IstB_IS21 PF01695.12 KII70599.1 - 0.00021 20.7 0.0 0.00071 19.0 0.0 1.9 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 KII70599.1 - 0.001 19.1 0.1 0.036 14.0 0.0 3.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_25 PF13481.1 KII70599.1 - 0.011 15.1 0.0 0.056 12.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KII70599.1 - 0.015 15.4 0.0 0.12 12.5 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 KII70599.1 - 0.021 14.3 0.0 0.1 12.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain SNAP PF14938.1 KII70601.1 - 0.00018 20.7 0.3 0.00022 20.4 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.1 KII70601.1 - 0.012 15.3 0.7 1.1 9.1 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4368 PF14287.1 KII70601.1 - 0.074 12.8 0.2 0.18 11.6 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4368) PDDEXK_1 PF12705.2 KII70602.1 - 0.13 11.5 0.7 0.14 11.5 0.5 1.1 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily AAA_assoc_C PF09821.4 KII70602.1 - 1.3 9.3 4.4 1.9 8.7 3.1 1.4 1 0 0 1 1 1 0 C-terminal AAA-associated domain SNAP PF14938.1 KII70603.1 - 0.0012 18.0 1.7 0.0021 17.2 1.2 1.5 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP WGG PF10273.4 KII70603.1 - 0.099 12.7 1.9 0.14 12.2 0.4 1.9 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 DUF445 PF04286.7 KII70603.1 - 0.1 12.1 13.0 0.17 11.4 9.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Dala_Dala_lig_N PF01820.16 KII70603.1 - 0.32 11.3 2.0 0.56 10.5 0.6 2.0 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus XH PF03469.9 KII70603.1 - 0.64 9.6 9.8 0.36 10.4 1.1 3.3 3 0 0 3 3 3 0 XH domain Lipoprotein_19 PF13617.1 KII70603.1 - 3.2 7.4 6.6 0.33 10.6 1.0 2.0 2 0 0 2 2 2 0 YnbE-like lipoprotein ATAD4 PF15321.1 KII70603.1 - 3.8 8.5 10.2 40 5.3 5.7 3.0 2 1 0 2 2 2 0 ATPase family AAA domain containing 4 DDE_3 PF13358.1 KII70604.1 - 4.6e-20 71.8 0.0 5.5e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII70604.1 - 9e-05 21.7 0.0 0.00011 21.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_6 PF13964.1 KII70605.1 - 7.5e-10 38.5 10.8 0.45 10.7 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KII70605.1 - 3.7e-06 26.4 8.6 0.68 9.7 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.20 KII70605.1 - 3.5e-05 23.2 17.4 0.0054 16.2 0.1 5.9 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.1 KII70605.1 - 9.4e-05 22.1 11.1 1.9 8.3 0.1 5.6 6 1 0 6 6 6 3 Galactose oxidase, central domain FBA_3 PF08268.7 KII70605.1 - 0.00075 19.2 0.5 0.3 10.8 0.3 2.4 2 0 0 2 2 2 2 F-box associated domain Kelch_3 PF13415.1 KII70605.1 - 0.002 18.2 3.4 3.1 8.0 0.0 4.4 4 0 0 4 4 4 1 Galactose oxidase, central domain YvrJ PF12841.2 KII70606.1 - 0.55 9.5 2.0 0.44 9.8 0.4 1.6 2 0 0 2 2 2 0 YvrJ protein family GlpM PF06942.7 KII70611.1 - 0.015 15.5 0.6 0.019 15.1 0.4 1.2 1 0 0 1 1 1 0 GlpM protein Replic_Relax PF13814.1 KII70612.1 - 0.045 13.6 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 Replication-relaxation YwpF PF14183.1 KII70612.1 - 0.089 12.4 0.0 1.6 8.4 0.0 2.1 1 1 1 2 2 2 0 YwpF-like protein Hs1pro-1_C PF07014.7 KII70614.1 - 0.046 13.0 0.5 0.065 12.5 0.3 1.2 1 1 0 1 1 1 0 Hs1pro-1 protein C-terminus YjgP_YjgQ PF03739.9 KII70616.1 - 0.011 14.5 0.2 0.011 14.5 0.1 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Imm7 PF15588.1 KII70616.1 - 0.15 12.1 2.2 1 9.3 0.1 2.2 1 1 1 2 2 2 0 Immunity protein 7 rve PF00665.21 KII70617.1 - 1.2e-29 102.9 0.0 3.5e-29 101.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII70617.1 - 1.1e-25 90.2 0.1 2.5e-25 89.1 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII70617.1 - 8.8e-06 25.5 0.1 2.4e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII70617.1 - 1.2e-05 24.8 0.0 4.2e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.18 KII70617.1 - 7.9e-05 22.3 10.1 0.016 15.0 1.6 2.8 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII70617.1 - 0.001 19.5 0.0 0.0026 18.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII70617.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.1 KII70617.1 - 0.0019 17.6 0.0 0.0068 15.9 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.6 KII70617.1 - 0.0025 17.7 0.4 0.0061 16.5 0.3 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII70617.1 - 0.014 15.0 1.4 0.014 15.0 1.0 2.8 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.1 KII70617.1 - 0.4 10.3 14.1 0.12 12.0 1.9 2.6 2 0 0 2 2 2 0 Zinc knuckle Peptidase_C1 PF00112.18 KII70619.1 - 2.4e-65 220.4 1.3 3.3e-65 220.0 0.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII70619.1 - 3.8e-08 33.4 0.7 7.3e-08 32.5 0.5 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KII70619.1 - 5.7e-06 25.1 0.1 9.2e-06 24.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase C1-like family Baculo_E56 PF04639.7 KII70619.1 - 0.059 12.0 0.0 0.17 10.5 0.0 1.7 2 0 0 2 2 2 0 Baculoviral E56 protein, specific to ODV envelope Peptidase_C39_2 PF13529.1 KII70619.1 - 0.09 13.1 0.3 0.28 11.5 0.0 2.0 2 0 0 2 2 2 0 Peptidase_C39 like family DUF4233 PF14017.1 KII70620.1 - 0.17 11.8 5.2 0.41 10.5 3.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4233) BPD_transp_2 PF02653.11 KII70620.1 - 0.64 8.9 3.8 0.88 8.4 2.6 1.4 1 1 0 1 1 1 0 Branched-chain amino acid transport system / permease component zf-BED PF02892.10 KII70621.1 - 0.028 14.1 0.1 0.057 13.1 0.1 1.5 1 0 0 1 1 1 0 BED zinc finger DDE_Tnp_IS1595 PF12762.2 KII70622.1 - 2.1e-09 37.3 0.3 3.2e-08 33.5 0.0 2.0 1 1 1 2 2 2 1 ISXO2-like transposase domain DUF3722 PF12519.3 KII70622.1 - 0.0061 15.8 0.0 0.0066 15.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) DUF2250 PF10007.4 KII70623.1 - 0.08 12.8 0.2 4.4 7.2 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) DDE_1 PF03184.14 KII70623.1 - 0.12 11.4 0.0 0.23 10.5 0.0 1.6 1 1 0 1 1 1 0 DDE superfamily endonuclease DUF3810 PF12725.2 KII70624.1 - 8.1 5.2 12.9 0.41 9.4 3.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) HTH_32 PF13565.1 KII70625.1 - 1.9e-10 41.3 0.0 4.1e-09 37.1 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.1 KII70625.1 - 2e-08 33.5 0.0 5e-07 29.1 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII70625.1 - 3.5e-08 33.5 0.0 5.2e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII70625.1 - 2.7e-06 27.2 0.2 2.6e-05 24.1 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain DDE_3 PF13358.1 KII70625.1 - 1.6e-05 24.6 0.0 4e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Toxin_64 PF15542.1 KII70625.1 - 0.00062 20.2 4.9 0.25 11.9 1.1 2.7 1 1 1 2 2 2 2 Putative toxin 64 HTH_Tnp_IS630 PF01710.11 KII70625.1 - 0.0014 18.3 0.1 0.0021 17.7 0.1 1.2 1 0 0 1 1 1 1 Transposase PAX PF00292.13 KII70625.1 - 0.0021 17.7 0.2 0.0043 16.7 0.1 1.5 1 0 0 1 1 1 1 'Paired box' domain TrmB PF01978.14 KII70625.1 - 0.0032 17.1 0.1 0.0072 16.0 0.1 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Tnp_Tc3_2 PF01498.13 KII70625.1 - 0.0046 16.9 0.2 0.064 13.3 0.0 2.5 2 1 0 2 2 2 1 Transposase HTH_40 PF14493.1 KII70625.1 - 0.0075 16.4 0.3 0.021 15.0 0.1 1.8 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.15 KII70625.1 - 0.0079 16.1 0.1 0.018 14.9 0.1 1.6 1 1 0 1 1 1 1 Transposase HTH_33 PF13592.1 KII70625.1 - 0.0091 15.5 0.0 0.02 14.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix Rep_3 PF01051.16 KII70625.1 - 0.019 14.5 0.1 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Initiator Replication protein HTH_Tnp_ISL3 PF13542.1 KII70625.1 - 0.099 11.8 0.0 0.27 10.4 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 DUF666 PF05006.7 KII70625.1 - 0.1 12.5 0.1 0.1 12.5 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF666) DUF1700 PF08006.6 KII70626.1 - 0.033 13.5 0.5 0.033 13.4 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Integrin_alpha PF00357.15 KII70627.1 - 0.53 10.1 0.1 0.53 10.1 0.1 3.1 3 0 0 3 3 3 0 Integrin alpha cytoplasmic region Srg PF02118.16 KII70628.1 - 0.0063 15.9 9.2 0.0082 15.6 6.4 1.2 1 0 0 1 1 1 1 Srg family chemoreceptor DUF4293 PF14126.1 KII70628.1 - 0.009 15.9 1.3 0.011 15.6 0.3 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4293) Claudin_2 PF13903.1 KII70628.1 - 0.029 14.0 6.0 0.082 12.5 4.5 1.5 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF898 PF05987.8 KII70628.1 - 0.037 12.9 4.7 0.047 12.5 3.3 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) BPD_transp_2 PF02653.11 KII70628.1 - 0.18 10.7 3.3 0.22 10.4 2.3 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component DUF4131 PF13567.1 KII70628.1 - 3.4 7.0 8.4 5 6.4 2.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF3546 PF12066.3 KII70630.1 - 0.062 13.3 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3546) PXPV PF12778.2 KII70632.1 - 1.1 8.9 3.7 5.9 6.6 0.3 2.3 2 0 0 2 2 2 0 PXPV repeat (3 copies) Ldl_recept_a PF00057.13 KII70633.1 - 4.9e-06 26.3 11.6 8.4e-06 25.5 8.0 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DSPc PF00782.15 KII70634.1 - 5.2e-05 22.8 0.0 8e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KII70634.1 - 0.002 17.5 0.0 0.0051 16.1 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KII70634.1 - 0.0029 17.6 0.0 0.0044 17.0 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate P3A PF08727.6 KII70634.1 - 0.063 12.6 0.1 1.5 8.1 0.0 2.5 2 0 0 2 2 2 0 Poliovirus 3A protein like DS PF01916.12 KII70636.1 - 0.032 13.3 0.1 0.47 9.5 0.0 2.0 2 0 0 2 2 2 0 Deoxyhypusine synthase Ldl_recept_a PF00057.13 KII70637.1 - 5.7e-13 48.5 27.5 2e-06 27.5 4.7 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.2 KII70637.1 - 0.18 11.3 14.9 0.34 10.4 10.3 1.4 1 1 0 1 1 1 0 Glucosidase II beta subunit-like Ldl_recept_a PF00057.13 KII70638.1 - 4.1e-35 119.3 90.8 4.5e-11 42.4 8.1 6.0 6 0 0 6 6 6 5 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII70639.1 - 1.8e-08 34.1 33.1 0.00018 21.3 8.1 2.7 1 1 2 3 3 3 3 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII70640.1 - 1.9e-12 46.8 30.5 2.8e-06 27.1 7.6 2.7 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A GerE PF00196.14 KII70642.1 - 1.8e-13 49.5 0.4 2.7e-13 48.9 0.3 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_7 PF02796.10 KII70642.1 - 4e-05 23.3 0.1 7.3e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase Sigma70_r4_2 PF08281.7 KII70642.1 - 0.00014 21.2 0.1 0.00021 20.6 0.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.1 KII70642.1 - 0.00025 20.6 0.0 0.00048 19.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 KII70642.1 - 0.0024 18.0 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII70642.1 - 0.042 13.8 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1492 PF07374.6 KII70642.1 - 0.062 13.4 0.8 0.082 13.0 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) HTH_40 PF14493.1 KII70642.1 - 0.063 13.5 0.6 0.11 12.6 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.1 KII70642.1 - 0.085 12.4 0.2 0.16 11.5 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain BSD PF03909.12 KII70643.1 - 0.025 14.3 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 BSD domain RVT_1 PF00078.22 KII70644.1 - 3.2e-15 56.0 0.1 1.3e-14 54.0 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII70644.1 - 1.9e-07 30.9 0.2 4.6e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII70644.1 - 2.8e-06 27.7 0.0 6.5e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII70644.1 - 7.7e-06 25.6 0.0 1.9e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII70644.1 - 0.0032 17.4 0.0 0.0068 16.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII70644.1 - 0.021 14.3 0.0 0.055 13.0 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.1 KII70644.1 - 0.061 12.8 3.9 0.16 11.5 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DDE_3 PF13358.1 KII70650.1 - 0.00019 21.2 0.0 0.00025 20.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease PAD PF03068.10 KII70652.1 - 0.025 12.9 0.1 0.027 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) FAD_binding_7 PF03441.9 KII70654.1 - 0.092 11.9 0.1 0.11 11.7 0.1 1.0 1 0 0 1 1 1 0 FAD binding domain of DNA photolyase 4F5 PF04419.9 KII70654.1 - 0.37 11.5 3.6 0.86 10.3 2.5 1.7 1 0 0 1 1 1 0 4F5 protein family Tox-HNH-EHHH PF15657.1 KII70655.1 - 0.13 12.3 2.6 0.39 10.9 1.8 1.9 1 1 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxins DDE_3 PF13358.1 KII70658.1 - 8.1e-21 74.3 0.0 1e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII70659.1 - 9e-21 74.0 0.0 1.3e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.2 KII70660.1 - 1e-06 28.6 0.0 1.8e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain Ribosomal_60s PF00428.14 KII70662.1 - 2.1e-11 44.0 0.2 2.7e-11 43.7 0.2 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein TSP9 PF11493.3 KII70662.1 - 0.028 14.9 2.2 0.044 14.3 1.5 1.3 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 CAP_N PF01213.14 KII70664.1 - 6.2e-51 173.5 3.8 9.7e-40 136.7 0.2 2.2 1 1 1 2 2 2 2 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.6 KII70664.1 - 7.5e-38 129.3 13.3 1.3e-37 128.6 9.2 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Succ_DH_flav_C PF02910.15 KII70664.1 - 0.039 13.7 0.3 1.2 9.0 0.1 2.6 2 0 0 2 2 2 0 Fumarate reductase flavoprotein C-term DUF310 PF03750.8 KII70664.1 - 0.13 12.4 0.1 0.45 10.7 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF310) TBCC PF07986.7 KII70664.1 - 0.24 10.8 10.5 0.17 11.3 1.4 2.3 1 1 1 2 2 2 0 Tubulin binding cofactor C HSP20 PF00011.16 KII70665.1 - 1.1e-16 60.5 0.4 2.7e-07 30.3 0.1 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family Ribosomal_L17 PF01196.14 KII70667.1 - 0.034 14.7 0.0 0.066 13.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L17 NusA_N PF08529.6 KII70669.1 - 0.066 13.2 0.0 0.082 12.8 0.0 1.2 1 0 0 1 1 1 0 NusA N-terminal domain Methyltransf_31 PF13847.1 KII70670.1 - 2.2e-11 43.5 0.1 3.5e-11 42.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KII70670.1 - 2.4e-11 43.3 0.3 3.5e-11 42.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 KII70670.1 - 1.8e-09 37.6 0.0 5.6e-09 36.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII70670.1 - 1.6e-08 34.8 0.0 6.4e-08 32.9 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KII70670.1 - 2.5e-08 34.4 0.1 5.2e-08 33.4 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 KII70670.1 - 5.1e-07 29.2 0.2 7.9e-07 28.6 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 KII70670.1 - 4.3e-06 26.5 0.0 1e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KII70670.1 - 3.3e-05 24.1 0.1 0.00019 21.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.4 KII70670.1 - 7e-05 22.3 0.1 0.00011 21.7 0.1 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 KII70670.1 - 0.00092 19.2 0.0 0.0013 18.7 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase TehB PF03848.9 KII70670.1 - 0.0014 17.8 0.3 0.0028 16.8 0.2 1.6 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_9 PF08003.6 KII70670.1 - 0.0026 16.5 0.0 0.0034 16.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.7 KII70670.1 - 0.009 16.4 0.0 0.017 15.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 KII70670.1 - 0.011 14.6 0.1 0.011 14.6 0.1 1.3 1 1 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Cons_hypoth95 PF03602.10 KII70670.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 UPF0020 PF01170.13 KII70670.1 - 0.031 13.8 0.1 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_24 PF13578.1 KII70670.1 - 0.068 14.0 0.0 0.2 12.5 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain CMAS PF02353.15 KII70670.1 - 0.07 12.2 0.0 0.097 11.7 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.1 KII70670.1 - 0.075 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain HEXIM PF15313.1 KII70671.1 - 0.11 12.6 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein Ubie_methyltran PF01209.13 KII70674.1 - 2.2e-72 242.9 0.1 2.8e-72 242.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KII70674.1 - 2.3e-21 75.9 0.0 8.7e-21 74.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII70674.1 - 4e-19 68.8 0.0 1.8e-18 66.8 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KII70674.1 - 6.5e-12 46.0 0.1 2.1e-11 44.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KII70674.1 - 8.4e-12 45.4 0.0 1.6e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KII70674.1 - 2.6e-11 43.7 0.0 6.5e-11 42.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KII70674.1 - 2.7e-10 40.1 0.0 4.1e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KII70674.1 - 1e-07 32.0 0.0 2.9e-07 30.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KII70674.1 - 0.00072 18.9 0.0 0.89 8.9 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase small domain UPF0020 PF01170.13 KII70674.1 - 0.0048 16.5 0.0 0.0079 15.7 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 DREV PF05219.7 KII70674.1 - 0.0053 15.6 0.0 0.015 14.1 0.0 1.7 1 1 1 2 2 2 1 DREV methyltransferase FtsJ PF01728.14 KII70674.1 - 0.0096 15.9 0.0 0.088 12.7 0.0 2.0 1 1 0 1 1 1 1 FtsJ-like methyltransferase DUF1257 PF06868.6 KII70674.1 - 0.066 13.1 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1257) MetW PF07021.7 KII70674.1 - 0.079 12.3 0.0 0.36 10.1 0.0 1.9 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW SAYSvFN PF10260.4 KII70678.1 - 1.2e-12 47.3 0.1 1.6e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) RRM_1 PF00076.17 KII70679.1 - 2.7e-18 65.3 0.0 3.4e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII70679.1 - 5.7e-10 39.0 0.0 7.1e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII70679.1 - 3.7e-06 26.6 0.0 4.6e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RuvB_N PF05496.7 KII70680.1 - 0.15 11.1 0.5 0.19 10.7 0.3 1.1 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus DUF383 PF04063.9 KII70682.1 - 0.00028 20.4 0.9 0.00031 20.3 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF383) DUF4631 PF15450.1 KII70682.1 - 0.0063 14.8 0.8 0.008 14.5 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4631) Syntaxin_2 PF14523.1 KII70682.1 - 0.16 11.9 2.6 0.32 11.0 1.7 1.8 1 1 0 1 1 1 0 Syntaxin-like protein BLOC1_2 PF10046.4 KII70682.1 - 0.24 11.5 3.4 0.54 10.4 1.8 2.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF848 PF05852.6 KII70682.1 - 0.78 9.5 4.2 0.85 9.4 2.5 1.3 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF4570 PF15134.1 KII70682.1 - 0.92 9.3 4.0 0.25 11.1 0.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Med28 PF11594.3 KII70682.1 - 1.1 9.4 4.8 0.6 10.3 1.2 1.8 1 1 1 2 2 2 0 Mediator complex subunit 28 Ldl_recept_a PF00057.13 KII70683.1 - 4e-06 26.6 14.7 4e-06 26.6 10.2 2.9 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A PRELI PF04707.9 KII70685.1 - 5.1e-05 22.8 0.2 6.3e-05 22.5 0.2 1.2 1 0 0 1 1 1 1 PRELI-like family Keratin_B2_2 PF13885.1 KII70686.1 - 5.2e-18 64.4 99.6 8.8e-05 22.1 16.6 4.2 1 1 3 4 4 4 4 Keratin, high sulfur B2 protein PMG PF05287.7 KII70686.1 - 1.6e-06 28.0 81.6 0.0024 17.7 27.0 2.1 1 1 1 2 2 2 2 PMG protein DDE_3 PF13358.1 KII70687.1 - 6e-11 42.2 0.0 0.00024 20.8 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease CLAMP PF14769.1 KII70687.1 - 0.084 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Flagellar C1a complex subunit C1a-32 DDE_3 PF13358.1 KII70689.1 - 4.8e-06 26.3 0.0 5.4e-06 26.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1947 PF09183.5 KII70690.1 - 0.0046 16.6 1.5 0.009 15.7 0.4 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF1947) DDE_3 PF13358.1 KII70691.1 - 1.3e-16 60.6 0.0 2.4e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII70691.1 - 5.5e-08 32.9 0.0 8.5e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII70691.1 - 0.00014 22.5 0.0 0.0003 21.5 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Arg_repressor PF01316.16 KII70691.1 - 0.00031 20.2 0.0 0.0023 17.4 0.0 2.3 2 0 0 2 2 2 1 Arginine repressor, DNA binding domain HTH_23 PF13384.1 KII70691.1 - 0.0014 18.2 0.0 0.31 10.7 0.0 2.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_4 PF13613.1 KII70691.1 - 0.0028 17.1 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix of DDE superfamily endonuclease DUF3336 PF11815.3 KII70691.1 - 0.0067 15.9 0.3 0.014 14.9 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) PAX PF00292.13 KII70691.1 - 0.026 14.2 0.1 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 'Paired box' domain HTH_33 PF13592.1 KII70691.1 - 0.043 13.3 0.0 0.079 12.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix Ank_2 PF12796.2 KII70693.1 - 5.5e-103 337.5 33.1 2.1e-18 66.4 0.5 9.3 3 2 6 9 9 9 8 Ankyrin repeats (3 copies) Ank PF00023.25 KII70693.1 - 4.3e-89 288.1 26.9 2.2e-07 30.3 0.2 16.4 16 0 0 16 16 16 14 Ankyrin repeat Ank_4 PF13637.1 KII70693.1 - 7.8e-78 255.6 22.4 3.4e-12 46.5 0.0 11.2 6 2 6 12 12 12 12 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII70693.1 - 1.3e-71 229.2 30.4 5.7e-05 22.9 0.3 18.1 18 0 0 18 18 18 14 Ankyrin repeat Ank_5 PF13857.1 KII70693.1 - 1.2e-68 225.6 21.0 9.1e-07 28.9 0.0 15.0 4 3 12 16 16 16 15 Ankyrin repeats (many copies) TGT PF01702.13 KII70695.1 - 0.0008 18.7 0.0 0.00096 18.4 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase PRANC PF09372.5 KII70695.1 - 0.57 10.1 5.1 0.33 10.9 0.7 2.5 2 1 2 4 4 4 0 PRANC domain MULE PF10551.4 KII70700.1 - 1.8e-08 34.4 0.0 4.4e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain RRM_5 PF13893.1 KII70705.1 - 5.2e-08 32.6 0.0 7.7e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII70705.1 - 1.3e-05 24.7 0.0 2.1e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 KII70705.1 - 3.2e-05 23.5 5.2 5.4e-05 22.7 3.6 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_6 PF14259.1 KII70705.1 - 0.0011 18.9 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PDGF_N PF04692.8 KII70706.1 - 0.034 14.6 0.3 0.69 10.4 0.0 2.3 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region LigA PF07746.6 KII70706.1 - 0.085 12.8 0.0 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit DUF3932 PF13068.1 KII70707.1 - 0.072 13.1 1.0 0.14 12.2 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3932) WD40 PF00400.27 KII70710.1 - 1.1e-13 50.4 0.0 3.5e-09 36.1 0.0 2.8 3 0 0 3 3 3 2 WD domain, G-beta repeat DDE_Tnp_IS1595 PF12762.2 KII70711.1 - 3.4e-10 39.9 0.0 3.9e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain PRESAN PF09687.5 KII70711.1 - 0.006 16.6 0.0 0.0072 16.3 0.0 1.1 1 0 0 1 1 1 1 Plasmodium RESA N-terminal Gemini_AL3 PF01407.12 KII70711.1 - 0.039 13.4 0.1 0.082 12.3 0.0 1.5 1 1 1 2 2 2 0 Geminivirus AL3 protein Clp1 PF06807.9 KII70712.1 - 8.5e-07 28.9 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 FragX_IP PF05994.6 KII70715.1 - 3.9e-122 408.6 25.4 6.4e-122 407.9 17.6 1.2 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF2711 PF10924.3 KII70715.1 - 0.0036 16.8 1.8 0.066 12.6 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF2711) FragX_IP PF05994.6 KII70718.1 - 3.2e-125 418.8 20.9 5.1e-125 418.2 14.5 1.2 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family GCC2_GCC3 PF07699.8 KII70723.1 - 0.0061 16.1 1.7 0.049 13.2 0.2 2.4 2 0 0 2 2 2 1 GCC2 and GCC3 zf-3CxxC PF13695.1 KII70723.1 - 1.5 9.1 10.2 4.4 7.5 0.0 3.4 2 2 2 4 4 4 0 Zinc-binding domain DUF4163 PF13739.1 KII70725.1 - 0.091 13.5 0.4 0.16 12.7 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4163) NTP_transf_2 PF01909.18 KII70725.1 - 0.11 12.8 0.0 0.27 11.5 0.0 1.6 1 1 0 1 1 1 0 Nucleotidyltransferase domain FLYWCH PF04500.11 KII70728.1 - 0.042 13.7 0.4 0.08 12.8 0.3 1.5 1 0 0 1 1 1 0 FLYWCH zinc finger domain DUF3787 PF12655.2 KII70728.1 - 0.045 13.4 0.2 0.23 11.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3787) Spt4 PF06093.8 KII70728.1 - 0.094 12.6 0.0 0.38 10.6 0.0 1.9 1 1 1 2 2 2 0 Spt4/RpoE2 zinc finger TBCC PF07986.7 KII70730.1 - 0.079 12.3 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor C Imm3 PF14425.1 KII70731.1 - 0.0079 16.1 0.1 0.014 15.3 0.1 1.3 1 0 0 1 1 1 1 Immunity protein Imm3 DUF4448 PF14610.1 KII70733.1 - 0.04 13.4 0.0 0.15 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF912 PF06024.7 KII70734.1 - 0.0019 18.2 0.0 0.0022 18.0 0.0 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Adeno_E3_CR2 PF02439.10 KII70734.1 - 0.01 15.3 0.1 0.017 14.6 0.1 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Rifin_STEVOR PF02009.11 KII70734.1 - 0.015 14.9 0.0 0.016 14.8 0.0 1.1 1 0 0 1 1 1 0 Rifin/stevor family Col_cuticle_N PF01484.12 KII70734.1 - 0.024 14.3 1.6 0.053 13.2 1.1 1.6 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain DUF3169 PF11368.3 KII70734.1 - 0.039 13.1 0.1 0.047 12.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF4448 PF14610.1 KII70734.1 - 0.053 13.0 0.0 0.061 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Syndecan PF01034.15 KII70734.1 - 0.095 12.3 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Syndecan domain DUF2893 PF11459.3 KII70735.1 - 0.057 13.2 0.1 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknwon function (DUF2893) ATP_bind_1 PF03029.12 KII70738.1 - 2.1e-30 106.0 0.0 2.7e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 KII70738.1 - 3.6e-07 31.0 0.0 4.2e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 KII70738.1 - 6.9e-07 28.4 0.0 8.5e-07 28.1 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein CbiA PF01656.18 KII70738.1 - 3.5e-05 23.2 0.0 3.9e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF87 PF01935.12 KII70738.1 - 6.6e-05 22.8 0.1 7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF87 SRP54 PF00448.17 KII70738.1 - 0.00015 21.3 0.2 0.0002 20.8 0.1 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Arch_ATPase PF01637.13 KII70738.1 - 0.00035 20.3 0.0 0.00035 20.3 0.0 1.1 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 KII70738.1 - 0.00038 20.6 0.0 0.00046 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KII70738.1 - 0.00045 20.1 0.0 0.00048 20.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII70738.1 - 0.00047 20.2 0.0 0.00059 19.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 KII70738.1 - 0.00059 18.7 0.1 0.00076 18.4 0.1 1.1 1 0 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.1 KII70738.1 - 0.00094 19.0 0.0 0.00098 19.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 KII70738.1 - 0.00097 18.4 0.0 0.0011 18.2 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 MobB PF03205.9 KII70738.1 - 0.001 18.8 0.1 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.9 KII70738.1 - 0.0014 17.6 0.0 0.0015 17.5 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain AAA_31 PF13614.1 KII70738.1 - 0.0017 18.2 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain UPF0079 PF02367.12 KII70738.1 - 0.0019 17.7 0.0 0.0027 17.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 KII70738.1 - 0.0025 17.4 0.1 0.0036 16.9 0.1 1.2 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.1 KII70738.1 - 0.0027 18.0 0.0 0.003 17.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KII70738.1 - 0.003 17.0 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 KII70738.1 - 0.0035 17.0 0.0 0.0049 16.5 0.0 1.2 1 0 0 1 1 1 1 Part of AAA domain cobW PF02492.14 KII70738.1 - 0.0042 16.5 0.1 0.0055 16.1 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.1 KII70738.1 - 0.0046 16.5 0.0 0.0057 16.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 KII70738.1 - 0.0059 16.9 0.2 0.0087 16.3 0.1 1.3 1 1 0 1 1 1 1 ABC transporter PduV-EutP PF10662.4 KII70738.1 - 0.006 16.0 0.1 0.0088 15.5 0.0 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation TrwB_AAD_bind PF10412.4 KII70738.1 - 0.0069 15.0 0.0 0.0079 14.8 0.0 1.1 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain Sigma54_activ_2 PF14532.1 KII70738.1 - 0.0099 15.9 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.13 KII70738.1 - 0.011 15.2 0.0 0.013 15.0 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA PF00004.24 KII70738.1 - 0.012 15.8 0.7 0.046 13.9 0.2 1.9 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) LpxK PF02606.9 KII70738.1 - 0.012 14.6 0.1 0.013 14.4 0.0 1.1 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase ArgK PF03308.11 KII70738.1 - 0.012 14.3 0.1 0.016 14.0 0.0 1.1 1 0 0 1 1 1 0 ArgK protein AAA_10 PF12846.2 KII70738.1 - 0.013 14.9 0.0 0.013 14.9 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain RNA_helicase PF00910.17 KII70738.1 - 0.016 15.3 0.1 0.027 14.6 0.1 1.4 1 1 0 1 1 1 0 RNA helicase G-alpha PF00503.15 KII70738.1 - 0.02 13.6 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.1 KII70738.1 - 0.021 14.8 0.0 0.021 14.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 KII70738.1 - 0.021 14.4 0.1 0.022 14.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.12 KII70738.1 - 0.021 14.1 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase Trm56 PF01994.11 KII70738.1 - 0.025 14.3 0.0 0.3 10.8 0.0 2.0 2 0 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 6PF2K PF01591.13 KII70738.1 - 0.025 13.6 0.2 0.036 13.1 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Miro PF08477.8 KII70738.1 - 0.036 14.5 0.2 0.042 14.3 0.2 1.3 1 1 0 1 1 1 0 Miro-like protein NTPase_1 PF03266.10 KII70738.1 - 0.037 13.7 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 NTPase Rad17 PF03215.10 KII70738.1 - 0.043 12.4 0.0 0.044 12.4 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Zeta_toxin PF06414.7 KII70738.1 - 0.044 12.8 0.0 0.06 12.4 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin APS_kinase PF01583.15 KII70738.1 - 0.055 13.1 0.0 0.065 12.8 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Sigma54_activat PF00158.21 KII70738.1 - 0.059 12.8 0.0 0.078 12.4 0.0 1.1 1 0 0 1 1 1 0 Sigma-54 interaction domain ArsA_ATPase PF02374.10 KII70738.1 - 0.06 12.3 0.1 0.091 11.7 0.0 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase PRK PF00485.13 KII70738.1 - 0.063 12.8 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family RNA12 PF10443.4 KII70738.1 - 0.064 11.7 0.0 0.071 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA12 protein Septin PF00735.13 KII70738.1 - 0.07 12.1 0.0 0.084 11.8 0.0 1.3 1 0 0 1 1 1 0 Septin Myosin_head PF00063.16 KII70738.1 - 0.07 11.1 0.0 0.075 11.0 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) PIF1 PF05970.9 KII70738.1 - 0.077 11.9 0.0 0.099 11.5 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase AAA_23 PF13476.1 KII70738.1 - 0.11 12.8 0.3 0.1 12.8 0.2 1.3 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 KII70738.1 - 0.11 12.1 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SRPRB PF09439.5 KII70738.1 - 0.11 11.6 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PhoH PF02562.11 KII70738.1 - 0.12 11.5 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein Arf PF00025.16 KII70738.1 - 0.14 11.4 0.1 0.19 10.9 0.1 1.4 1 1 0 1 1 1 0 ADP-ribosylation factor family DUF1244 PF06844.6 KII70740.1 - 0.0048 16.7 0.7 1.7 8.5 0.4 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF1244) Ldl_recept_a PF00057.13 KII70741.1 - 1.2e-08 34.6 10.1 1.7e-08 34.1 7.0 1.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII70742.1 - 0.068 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 BNR/Asp-box repeat PAN_3 PF08277.7 KII70743.1 - 0.031 13.8 0.3 0.054 13.1 0.2 1.4 1 0 0 1 1 1 0 PAN-like domain WW PF00397.21 KII70745.1 - 0.53 10.1 2.4 2.6 8.0 1.3 2.1 2 0 0 2 2 2 0 WW domain DUF4371 PF14291.1 KII70746.1 - 0.001 18.6 0.1 0.0013 18.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) HTH_33 PF13592.1 KII70750.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn helix DDE_3 PF13358.1 KII70751.1 - 9.3e-05 22.2 0.1 0.00012 21.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_6 PF13964.1 KII70759.1 - 2e-21 75.2 15.6 0.00015 21.8 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 KII70759.1 - 2.3e-21 75.3 7.8 6.5e-05 22.9 0.0 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII70759.1 - 6e-19 67.3 17.0 1.2e-06 27.9 0.5 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 KII70759.1 - 7.4e-17 60.8 15.7 0.0015 18.2 0.0 6.2 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.10 KII70759.1 - 3.8e-11 42.2 12.3 0.011 15.4 0.3 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 KII70759.1 - 5e-06 26.3 8.8 0.19 11.7 0.6 5.4 6 0 0 6 6 6 3 Kelch motif PDZ PF00595.19 KII70764.1 - 1.3e-08 34.8 0.0 2.7e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII70764.1 - 0.0039 17.0 0.0 0.0082 16.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GCP5-Mod21 PF14609.1 KII70766.1 - 0.0085 14.2 0.1 0.0088 14.2 0.1 1.1 1 0 0 1 1 1 1 gamma-Tubulin ring complex non-core subunit mod21 SVA PF05326.6 KII70766.1 - 0.026 14.2 3.6 0.51 10.1 1.7 2.0 1 1 1 2 2 2 0 Seminal vesicle autoantigen (SVA) SLY PF12485.3 KII70766.1 - 0.051 13.8 0.6 0.059 13.5 0.4 1.1 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein DUF325 PF03804.8 KII70766.1 - 0.059 13.0 0.0 0.079 12.6 0.0 1.2 1 0 0 1 1 1 0 Viral domain of unknown function SMI1_KNR4 PF09346.5 KII70768.1 - 0.076 13.0 0.3 0.38 10.7 0.0 2.0 2 0 0 2 2 2 0 SMI1 / KNR4 family (SUKH-1) DegV PF02645.11 KII70769.1 - 0.085 11.9 0.0 0.09 11.8 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 rve PF00665.21 KII70770.1 - 1.2e-14 54.4 0.0 2e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70770.1 - 0.00027 20.3 0.1 0.0004 19.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Sec23_helical PF04815.10 KII70770.1 - 0.043 13.2 0.1 0.076 12.4 0.0 1.5 1 1 0 1 1 1 0 Sec23/Sec24 helical domain DDE_3 PF13358.1 KII70771.1 - 4.9e-11 42.5 0.5 1.3e-09 37.9 0.3 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF764 PF05561.6 KII70772.1 - 0.0065 15.9 0.1 0.074 12.4 0.0 2.0 1 1 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF764) EIIA-man PF03610.11 KII70772.1 - 0.052 13.6 0.0 4.1 7.5 0.0 2.1 1 1 1 2 2 2 0 PTS system fructose IIA component Ins134_P3_kin PF05770.6 KII70773.1 - 1.1e-39 136.2 0.2 1.4e-39 135.9 0.1 1.1 1 0 0 1 1 1 1 Inositol 1, 3, 4-trisphosphate 5/6-kinase Pkinase PF00069.20 KII70774.1 - 1.8e-13 50.2 0.0 5e-13 48.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII70774.1 - 1.7e-09 37.1 0.0 5.8e-09 35.3 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase TRAP-gamma PF07074.7 KII70774.1 - 0.046 13.2 0.2 0.089 12.3 0.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Curto_V2 PF07325.6 KII70774.1 - 0.087 12.4 1.2 0.17 11.5 0.9 1.4 1 0 0 1 1 1 0 Curtovirus V2 protein DDE_3 PF13358.1 KII70776.1 - 3.6e-16 59.2 0.1 6.2e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII70776.1 - 7.3e-05 22.8 0.0 0.0002 21.5 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.1 KII70776.1 - 0.0016 18.0 0.2 0.34 10.6 0.0 3.0 3 0 0 3 3 3 1 Homeodomain-like domain PAX PF00292.13 KII70776.1 - 0.0044 16.7 0.2 0.017 14.8 0.1 2.0 1 1 1 2 2 2 1 'Paired box' domain HTH_28 PF13518.1 KII70776.1 - 0.0068 16.3 0.2 3.3 7.8 0.1 2.6 2 0 0 2 2 2 2 Helix-turn-helix domain Helicase_RecD PF05127.9 KII70776.1 - 0.04 13.5 0.0 2.3 7.8 0.0 2.4 1 1 1 2 2 2 0 Helicase HTH_Tnp_Tc3_2 PF01498.13 KII70776.1 - 0.071 13.1 0.1 0.34 10.9 0.0 2.2 2 0 0 2 2 2 0 Transposase ERAP1_C PF11838.3 KII70777.1 - 9.3e-31 107.2 0.0 1.2e-30 106.9 0.0 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.15 KII70777.1 - 0.0018 17.4 0.0 0.0025 16.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 Peptidase_M1 PF01433.15 KII70778.1 - 5.6e-57 193.5 1.6 6.4e-57 193.4 1.1 1.0 1 0 0 1 1 1 1 Peptidase family M1 Tau95 PF09734.4 KII70779.1 - 1.8e-12 47.2 0.0 3e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit TFIIF_beta PF02270.10 KII70779.1 - 0.13 11.9 0.0 0.32 10.7 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IIF, beta subunit Tau95 PF09734.4 KII70780.1 - 2.7e-11 43.3 0.0 3.1e-11 43.1 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit PI3_PI4_kinase PF00454.22 KII70783.1 - 5.3e-52 176.6 0.1 1.2e-51 175.5 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 KII70783.1 - 1.8e-16 60.1 1.3 2.3e-15 56.4 0.9 2.5 1 1 0 1 1 1 1 FAT domain FATC PF02260.15 KII70783.1 - 1.1e-13 50.3 0.0 2.6e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 FATC domain UME PF08064.8 KII70783.1 - 5e-13 48.9 3.9 8.7e-13 48.1 0.6 3.1 2 0 0 2 2 2 1 UME (NUC010) domain TRM PF02005.11 KII70784.1 - 1.7e-83 280.6 0.0 2e-83 280.4 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DDE_3 PF13358.1 KII70785.1 - 7.7e-12 45.1 0.0 9.3e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease UQ_con PF00179.21 KII70786.1 - 6.3e-45 152.0 0.0 1.5e-44 150.8 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KII70786.1 - 0.0019 17.9 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KII70786.1 - 0.002 17.9 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 KII70786.1 - 0.02 14.5 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain G-gamma PF00631.17 KII70786.1 - 0.11 12.2 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 GGL domain Imm48 PF15587.1 KII70788.1 - 0.11 11.9 1.5 0.13 11.5 1.0 1.1 1 0 0 1 1 1 0 Immunity protein 48 GlpM PF06942.7 KII70788.1 - 0.75 10.0 5.0 0.96 9.7 3.5 1.1 1 0 0 1 1 1 0 GlpM protein FLYWCH PF04500.11 KII70789.1 - 5.2e-10 39.0 3.4 1.1e-09 38.0 2.4 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain DCP1 PF06058.8 KII70789.1 - 0.032 14.2 0.2 0.082 12.9 0.0 1.7 2 0 0 2 2 2 0 Dcp1-like decapping family rve PF00665.21 KII70791.1 - 5.7e-28 97.4 0.0 1.1e-27 96.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII70791.1 - 2.2e-24 86.0 0.0 4.9e-24 84.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII70791.1 - 0.0024 17.3 0.1 0.0056 16.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII70791.1 - 0.011 15.1 0.3 0.05 13.0 0.0 2.3 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger GSH_synth_ATP PF03917.12 KII70791.1 - 0.047 12.2 0.0 0.073 11.6 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain DDE_Tnp_IS1595 PF12762.2 KII70792.1 - 3.2e-15 56.2 0.0 3.8e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain PPTA PF01239.17 KII70794.1 - 3.4e-37 124.2 18.4 1.4e-11 43.1 1.0 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Sec16_C PF12931.2 KII70795.1 - 1.3e-12 48.0 0.4 2.3e-12 47.2 0.3 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.2 KII70795.1 - 0.024 14.6 0.0 0.024 14.6 0.0 2.6 3 0 0 3 3 3 0 Vesicle coat trafficking protein Sec16 mid-region MH1 PF03165.11 KII70797.1 - 3.3e-34 116.9 1.8 4.1e-34 116.6 1.3 1.1 1 0 0 1 1 1 1 MH1 domain CHAD PF05235.9 KII70797.1 - 0.089 12.3 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 CHAD domain RVT_1 PF00078.22 KII70798.1 - 2.1e-23 82.8 0.0 3.5e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.9 KII70798.1 - 0.097 11.6 0.1 0.32 9.9 0.0 1.8 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_3 PF13358.1 KII70799.1 - 2.3e-05 24.1 0.0 2.5e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII70800.1 - 6.7e-24 84.3 0.0 2.4e-22 79.2 0.0 2.3 1 1 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII70800.1 - 2.2e-06 27.7 0.0 5.5e-06 26.4 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain HTH_23 PF13384.1 KII70800.1 - 0.00012 21.6 0.2 0.0046 16.5 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII70800.1 - 0.00031 20.6 0.4 0.00073 19.4 0.1 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII70800.1 - 0.0007 19.7 0.9 0.0018 18.4 0.3 1.9 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.1 KII70800.1 - 0.0022 17.4 3.8 1.1 8.8 0.3 2.8 3 0 0 3 3 3 2 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII70800.1 - 0.0055 16.7 0.1 0.016 15.2 0.1 1.8 1 0 0 1 1 1 1 Transposase HTH_5 PF01022.15 KII70800.1 - 0.0066 16.0 0.3 0.023 14.3 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_Tnp_1 PF01527.15 KII70800.1 - 0.035 14.0 0.0 0.094 12.6 0.0 1.7 1 0 0 1 1 1 0 Transposase DUF1662 PF07878.6 KII70800.1 - 0.067 12.9 0.2 0.17 11.6 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1662) DDE_1 PF03184.14 KII70800.1 - 0.096 11.8 0.1 0.21 10.7 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_3 PF13358.1 KII70804.1 - 3.4e-12 46.3 0.3 8e-08 32.1 0.0 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease Rad51 PF08423.6 KII70804.1 - 0.059 12.2 0.2 0.093 11.6 0.1 1.2 1 0 0 1 1 1 0 Rad51 LEF-4 PF05098.7 KII70805.1 - 0.023 13.4 0.0 0.024 13.4 0.0 1.1 1 0 0 1 1 1 0 Late expression factor 4 (LEF-4) DUF1237 PF06824.6 KII70806.1 - 0.11 11.1 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1237) Kelch_6 PF13964.1 KII70807.1 - 1.2e-17 63.2 14.4 7.3e-05 22.7 0.2 6.4 5 2 1 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII70807.1 - 2e-13 49.8 17.9 6.5e-06 25.8 0.3 6.3 6 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_3 PF13415.1 KII70807.1 - 4.7e-13 48.8 7.6 0.00031 20.8 0.1 6.9 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII70807.1 - 3.8e-12 45.5 8.4 0.0052 16.2 0.8 6.2 6 2 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 KII70807.1 - 1.3e-05 24.7 7.7 3.9 7.3 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 KII70807.1 - 3.5e-05 23.6 1.6 0.98 9.4 0.0 4.3 4 0 0 4 4 4 2 Kelch motif DUF2577 PF10844.3 KII70809.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2577) rve PF00665.21 KII70810.1 - 8.2e-23 80.7 0.0 1.1e-22 80.4 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70810.1 - 0.028 13.9 0.0 0.064 12.7 0.0 1.6 2 0 0 2 2 2 0 Integrase core domain cwf21 PF08312.7 KII70814.1 - 0.0086 15.9 0.3 0.021 14.6 0.2 1.7 1 0 0 1 1 1 1 cwf21 domain Pilus_CpaD PF09476.5 KII70814.1 - 0.049 13.1 0.0 0.062 12.7 0.0 1.2 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) Vezatin PF12632.2 KII70815.1 - 0.068 12.2 0.1 0.073 12.1 0.1 1.1 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes PBP PF01161.15 KII70816.1 - 0.05 13.4 0.1 0.054 13.3 0.1 1.2 1 0 0 1 1 1 0 Phosphatidylethanolamine-binding protein BLYB PF05289.6 KII70819.1 - 0.037 13.8 1.2 0.64 9.8 0.0 2.2 1 1 1 2 2 2 0 Borrelia hemolysin accessory protein RNase_H PF00075.19 KII70823.1 - 0.0089 16.3 0.3 0.047 14.0 0.0 2.0 2 0 0 2 2 2 1 RNase H PipA PF07108.6 KII70824.1 - 0.11 11.8 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 PipA protein HTH_Tnp_Tc3_2 PF01498.13 KII70825.1 - 0.00011 22.1 0.0 0.00016 21.6 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII70825.1 - 0.0054 17.4 0.0 0.013 16.2 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII70825.1 - 0.0086 16.2 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_33 PF13592.1 KII70825.1 - 0.015 14.8 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix FimP PF09766.4 KII70825.1 - 0.046 12.7 0.0 0.053 12.5 0.0 1.1 1 0 0 1 1 1 0 Fms-interacting protein MP PF01107.13 KII70829.1 - 0.11 11.9 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Viral movement protein (MP) DDE_3 PF13358.1 KII70830.1 - 2.4e-33 114.9 0.1 3.5e-33 114.4 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII70830.1 - 0.017 15.2 0.0 0.041 13.9 0.0 1.8 2 1 0 2 2 2 0 Integrase core domain HTH_Tnp_Tc3_2 PF01498.13 KII70830.1 - 0.02 14.9 0.0 0.057 13.4 0.0 1.8 1 0 0 1 1 1 0 Transposase Zot PF05707.7 KII70830.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.5 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) Retrotrans_gag PF03732.12 KII70831.1 - 3.8e-05 23.6 0.1 0.0001 22.3 0.0 1.6 2 0 0 2 2 2 1 Retrotransposon gag protein Arm PF00514.18 KII70832.1 - 3.3e-17 61.6 2.6 0.00014 21.5 0.0 7.2 8 0 0 8 8 8 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KII70832.1 - 6.3e-05 23.3 0.0 6.9 7.3 0.0 4.1 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.1 KII70832.1 - 0.00016 21.8 0.0 0.55 10.5 0.0 3.5 4 1 0 4 4 4 2 HEAT repeats HEAT PF02985.17 KII70832.1 - 0.0019 18.1 0.1 2.9 8.2 0.0 3.8 3 0 0 3 3 3 2 HEAT repeat GBP_C PF02841.9 KII70832.1 - 0.15 11.2 1.4 0.14 11.2 0.2 1.4 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Arm PF00514.18 KII70834.1 - 2.1e-15 55.8 1.6 0.0065 16.2 0.1 7.1 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KII70834.1 - 3e-07 30.7 0.0 0.43 11.1 0.0 3.7 3 0 0 3 3 3 3 HEAT-like repeat HEAT_2 PF13646.1 KII70834.1 - 0.0021 18.2 0.0 2.3 8.5 0.0 3.3 3 2 1 4 4 4 2 HEAT repeats IBB PF01749.15 KII70834.1 - 0.032 14.4 0.7 0.054 13.6 0.5 1.3 1 0 0 1 1 1 0 Importin beta binding domain Resolvase PF00239.16 KII70834.1 - 0.079 12.8 0.5 0.24 11.2 0.1 1.8 2 0 0 2 2 2 0 Resolvase, N terminal domain SH PF01445.12 KII70835.1 - 0.0059 16.2 0.1 0.009 15.6 0.1 1.3 1 0 0 1 1 1 1 Viral small hydrophobic protein CD34_antigen PF06365.7 KII70835.1 - 0.055 13.1 0.0 0.058 13.0 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF445 PF04286.7 KII70839.1 - 0.054 13.0 1.0 0.064 12.7 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Bro-N PF02498.12 KII70841.1 - 0.11 12.8 0.0 0.16 12.2 0.0 1.3 1 1 0 1 1 1 0 BRO family, N-terminal domain FliD_C PF07195.7 KII70845.1 - 0.0044 16.3 2.4 0.0053 16.0 1.7 1.1 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus DUF3670 PF12419.3 KII70845.1 - 0.019 14.3 0.1 0.027 13.9 0.1 1.3 1 0 0 1 1 1 0 SNF2 Helicase protein DUF3022 PF11226.3 KII70845.1 - 0.09 12.6 0.3 0.16 11.8 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3022) THOC7 PF05615.8 KII70845.1 - 0.1 12.8 4.5 0.22 11.8 3.1 1.6 1 1 0 1 1 1 0 Tho complex subunit 7 DUF948 PF06103.6 KII70845.1 - 0.12 12.2 1.9 0.98 9.3 0.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Exonuc_VII_L PF02601.10 KII70845.1 - 0.17 11.0 4.3 0.23 10.6 3.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PrkA PF06798.7 KII70845.1 - 0.17 11.1 4.4 0.11 11.7 0.9 1.8 1 1 1 2 2 2 0 PrkA serine protein kinase C-terminal domain DUF489 PF04356.7 KII70845.1 - 0.19 11.3 2.9 0.35 10.4 2.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF489) DUF3106 PF11304.3 KII70845.1 - 0.29 11.5 3.7 0.17 12.2 0.5 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) FlaF PF07309.6 KII70845.1 - 0.34 10.7 3.7 0.21 11.4 0.7 1.8 1 1 0 2 2 2 0 Flagellar protein FlaF DUF2153 PF09921.4 KII70845.1 - 0.52 9.9 3.9 0.37 10.4 0.3 2.2 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2153) DUF1319 PF07028.6 KII70845.1 - 3 8.0 9.3 1.2 9.2 2.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Herpes_UL37_2 PF07413.6 KII70846.1 - 0.1 11.3 0.2 0.12 11.0 0.1 1.2 1 0 0 1 1 1 0 Betaherpesvirus immediate-early glycoprotein UL37 Uricase PF01014.13 KII70848.1 - 3.1 7.8 7.9 2.6 8.1 3.8 2.1 2 2 0 2 2 2 0 Uricase rve PF00665.21 KII70849.1 - 4.1e-05 23.6 0.0 8.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Peptidase_S15 PF02129.13 KII70849.1 - 0.015 14.7 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) RVP PF00077.15 KII70849.1 - 0.052 13.4 0.1 0.93 9.4 0.0 2.8 3 0 0 3 3 3 0 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII70849.1 - 0.07 13.6 0.0 0.22 12.0 0.0 1.9 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII70849.1 - 0.15 11.9 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease YrvL PF14184.1 KII70850.1 - 0.057 13.2 10.9 0.077 12.7 7.5 1.2 1 0 0 1 1 1 0 Regulatory protein YrvL Cation_ATPase_C PF00689.16 KII70850.1 - 1 8.8 8.0 2 7.8 5.5 1.5 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus rve PF00665.21 KII70851.1 - 9.3e-19 67.7 0.1 1.4e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70851.1 - 3.1e-05 23.4 0.0 5.9e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF4583 PF15190.1 KII70851.1 - 0.0067 16.0 0.3 0.015 14.9 0.2 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4583) DNAJ_related PF12339.3 KII70852.1 - 0.13 12.0 4.4 0.3 10.9 3.1 1.7 1 1 0 1 1 1 0 DNA-J related protein LRS4 PF10422.4 KII70852.1 - 0.19 11.0 5.7 0.2 10.9 4.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Retrotrans_gag PF03732.12 KII70853.1 - 3.1e-05 23.9 0.6 9.6e-05 22.3 0.2 1.9 1 1 1 2 2 2 1 Retrotransposon gag protein UBN2 PF14223.1 KII70853.1 - 0.2 11.4 2.2 2.4 7.9 0.1 2.2 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type Tropomyosin PF00261.15 KII70854.1 - 0.0031 16.6 2.6 0.0042 16.2 1.8 1.3 1 0 0 1 1 1 1 Tropomyosin TMF_TATA_bd PF12325.3 KII70854.1 - 0.0085 15.8 7.2 0.14 11.9 1.3 2.1 2 0 0 2 2 2 2 TATA element modulatory factor 1 TATA binding COG2 PF06148.6 KII70854.1 - 0.018 14.9 0.2 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.5 KII70854.1 - 0.055 13.6 10.5 0.66 10.0 5.8 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Abi_2 PF07751.6 KII70854.1 - 0.06 13.5 4.3 0.094 12.8 3.0 1.4 1 0 0 1 1 1 0 Abi-like protein Lebercilin PF15619.1 KII70854.1 - 0.082 12.3 10.2 0.32 10.4 1.2 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Spc24 PF08286.6 KII70854.1 - 0.085 12.5 6.3 0.62 9.7 1.0 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Sec2p PF06428.6 KII70854.1 - 0.1 12.4 4.3 2.7 7.9 0.2 2.2 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Tropomyosin_1 PF12718.2 KII70854.1 - 0.16 11.7 8.6 0.53 10.1 0.3 2.1 2 0 0 2 2 2 0 Tropomyosin like DUF869 PF05911.6 KII70854.1 - 0.22 9.6 4.6 0.28 9.3 3.2 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Laminin_II PF06009.7 KII70854.1 - 0.25 11.0 5.6 0.36 10.6 0.5 2.0 2 0 0 2 2 2 0 Laminin Domain II FlaC_arch PF05377.6 KII70854.1 - 0.27 11.1 5.7 0.92 9.4 1.8 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Myosin_tail_1 PF01576.14 KII70854.1 - 0.27 8.8 9.3 0.73 7.4 2.1 2.0 1 1 1 2 2 2 0 Myosin tail Syntaxin-6_N PF09177.6 KII70854.1 - 0.31 11.4 3.3 0.52 10.7 0.6 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Tup_N PF08581.5 KII70854.1 - 0.62 10.2 9.0 5.8 7.1 2.7 2.6 1 1 1 2 2 2 0 Tup N-terminal APG6 PF04111.7 KII70854.1 - 0.72 8.8 7.4 0.91 8.5 2.0 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 CENP-F_leu_zip PF10473.4 KII70854.1 - 1.4 8.7 8.2 6.8 6.5 1.7 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin_2 PF14523.1 KII70854.1 - 2.1 8.4 8.9 1.8 8.6 0.7 2.4 2 1 0 2 2 2 0 Syntaxin-like protein Prefoldin_2 PF01920.15 KII70854.1 - 3.9 7.2 10.6 9.6 6.0 0.5 2.5 2 0 0 2 2 2 0 Prefoldin subunit Osmo_CC PF08946.5 KII70854.1 - 3.9 7.5 6.8 23 5.1 0.0 3.2 3 1 0 3 3 3 0 Osmosensory transporter coiled coil CDC37_N PF03234.9 KII70854.1 - 4.6 7.5 8.2 7.6 6.8 1.4 2.0 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Hs1pro-1_C PF07014.7 KII70855.1 - 0.099 11.9 0.8 0.11 11.7 0.6 1.1 1 0 0 1 1 1 0 Hs1pro-1 protein C-terminus Flagellin_C PF00700.16 KII70855.1 - 0.37 10.9 4.7 0.51 10.5 1.0 2.2 1 1 1 2 2 2 0 Bacterial flagellin C-terminal helical region Laminin_II PF06009.7 KII70857.1 - 0.0021 17.7 4.1 0.029 14.1 0.4 2.1 2 0 0 2 2 2 1 Laminin Domain II RmuC PF02646.11 KII70857.1 - 0.0045 15.8 6.5 0.028 13.2 0.5 2.1 2 0 0 2 2 2 2 RmuC family FliD_C PF07195.7 KII70857.1 - 0.0098 15.2 4.4 0.03 13.6 3.1 1.8 1 1 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus DUF4164 PF13747.1 KII70857.1 - 0.044 13.9 0.6 0.15 12.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DUF1664 PF07889.7 KII70857.1 - 0.11 12.2 2.5 0.32 10.7 1.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.2 KII70857.1 - 0.18 11.6 4.8 1.1 9.0 0.8 2.1 1 1 1 2 2 2 0 Tropomyosin like HemX PF04375.9 KII70857.1 - 0.24 9.9 4.2 0.15 10.6 1.7 1.5 1 1 0 1 1 1 0 HemX Syntaxin PF00804.20 KII70857.1 - 0.26 11.4 9.1 4.1 7.6 6.3 2.3 1 1 0 1 1 1 0 Syntaxin TMF_DNA_bd PF12329.3 KII70857.1 - 0.36 10.6 2.6 0.45 10.3 0.4 2.2 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIVA PF05103.8 KII70857.1 - 0.36 10.8 5.2 2.4 8.2 0.7 2.1 2 0 0 2 2 2 0 DivIVA protein IncA PF04156.9 KII70857.1 - 0.79 9.2 6.2 5.1 6.6 3.5 1.9 1 1 1 2 2 2 0 IncA protein Jnk-SapK_ap_N PF09744.4 KII70857.1 - 1.3 9.0 6.8 2.4 8.1 3.6 1.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 ADIP PF11559.3 KII70857.1 - 2.7 7.9 12.1 6 6.7 3.1 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding YlqD PF11068.3 KII70857.1 - 3.9 7.5 8.4 19 5.2 2.5 2.2 2 0 0 2 2 2 0 YlqD protein NUMOD1 PF07453.8 KII70860.1 - 0.011 15.5 0.4 1.7 8.6 0.0 2.9 2 0 0 2 2 2 0 NUMOD1 domain PIN_2 PF10130.4 KII70860.1 - 0.29 11.1 2.5 2.3 8.2 0.9 2.0 1 1 1 2 2 2 0 PIN domain TRCF PF03461.10 KII70860.1 - 0.34 10.8 6.0 0.26 11.2 0.2 2.8 1 1 2 3 3 3 0 TRCF domain Band_3_cyto PF07565.8 KII70860.1 - 1.1 8.6 5.1 1.3 8.4 3.5 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain HTH_11 PF08279.7 KII70860.1 - 1.3 8.7 4.5 0.38 10.4 0.4 2.1 2 0 0 2 2 2 0 HTH domain Mga PF05043.8 KII70860.1 - 1.9 8.8 7.9 1.1 9.6 3.4 1.9 1 1 1 2 2 2 0 Mga helix-turn-helix domain FlaC_arch PF05377.6 KII70860.1 - 2.5 8.0 6.8 0.49 10.3 0.4 2.7 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Hormone_1 PF00103.15 KII70860.1 - 3.2 7.0 7.4 0.26 10.6 0.3 2.0 1 1 1 2 2 2 0 Somatotropin hormone family DUF948 PF06103.6 KII70860.1 - 6 6.8 6.8 1.2 9.0 0.2 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.17 KII70860.1 - 6.3 6.8 11.9 3 7.9 0.6 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF972 PF06156.8 KII70860.1 - 8.1 6.8 8.4 7.2 7.0 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) SNAP PF14938.1 KII70862.1 - 0.1 11.7 8.5 0.26 10.3 5.9 1.8 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_1 PF00515.23 KII70862.1 - 1.1 9.0 10.7 3.5 7.3 0.1 4.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII70862.1 - 3.2 7.7 6.9 6.8 6.7 0.0 4.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII70862.1 - 4.6 7.3 12.0 8.5 6.5 0.1 4.9 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF4368 PF14287.1 KII70863.1 - 0.0099 15.6 0.8 0.023 14.4 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4368) FAM91_N PF14647.1 KII70863.1 - 0.047 12.7 0.5 0.055 12.5 0.3 1.4 1 0 0 1 1 1 0 FAM91 N-terminus DUF1477 PF07346.6 KII70863.1 - 0.12 12.4 3.8 2.9 7.9 2.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1477) EF-hand_8 PF13833.1 KII70865.1 - 0.092 12.3 0.4 0.53 9.9 0.1 2.4 3 0 0 3 3 3 0 EF-hand domain pair SNAP PF14938.1 KII70867.1 - 2e-06 27.1 0.9 2.4e-06 26.8 0.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Rad50_zn_hook PF04423.9 KII70867.1 - 0.02 14.3 1.1 0.053 13.0 0.1 2.2 2 1 0 2 2 2 0 Rad50 zinc hook motif TPR_11 PF13414.1 KII70867.1 - 0.4 10.3 3.9 10 5.8 0.0 3.3 3 1 1 4 4 4 0 TPR repeat TPR_1 PF00515.23 KII70867.1 - 0.84 9.3 10.3 2.3 7.9 0.3 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII70867.1 - 0.85 9.6 8.5 20 5.4 0.2 4.4 3 1 0 4 4 4 0 Tetratricopeptide repeat Serpin PF00079.15 KII70869.1 - 4e-18 65.7 0.3 4.6e-18 65.5 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-UBR PF02207.15 KII70870.1 - 4.5e-12 45.5 21.4 1.1e-11 44.2 14.8 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) F_actin_bind PF08919.5 KII70870.1 - 0.016 14.8 0.1 0.069 12.8 0.1 2.1 1 0 0 1 1 1 0 F-actin binding Dzip-like_N PF13815.1 KII70870.1 - 0.027 14.2 1.6 1.4 8.7 0.2 2.7 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF2470 PF10615.4 KII70870.1 - 0.083 13.1 0.4 0.26 11.5 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) Myb_DNA-bind_6 PF13921.1 KII70872.1 - 1.5e-13 50.6 1.4 1.6e-06 28.0 0.0 4.4 3 1 1 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KII70872.1 - 3.3e-09 36.6 3.5 1.1e-05 25.4 0.1 4.6 3 1 0 3 3 3 1 Myb-like DNA-binding domain DUF1703 PF08011.6 KII70872.1 - 0.00038 20.1 2.4 0.67 9.7 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1703) DbpA PF03880.10 KII70872.1 - 0.0017 18.0 3.1 1.2 8.8 0.1 3.1 3 0 0 3 3 3 2 DbpA RNA binding domain MethyltransfD12 PF02086.10 KII70872.1 - 0.0033 16.9 5.1 0.49 9.8 0.3 2.3 2 0 0 2 2 2 2 D12 class N6 adenine-specific DNA methyltransferase DUF1736 PF08409.6 KII70872.1 - 0.032 13.7 0.0 12 5.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1736) Gag_p19 PF02228.11 KII70872.1 - 0.034 14.4 1.9 16 5.8 0.0 3.6 2 2 3 5 5 5 0 Major core protein p19 PqqD PF05402.7 KII70872.1 - 0.042 13.8 0.2 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) H2TH PF06831.9 KII70872.1 - 0.073 12.8 0.0 20 5.0 0.0 2.8 2 0 0 2 2 2 0 Formamidopyrimidine-DNA glycosylase H2TH domain Succ_CoA_lig PF13607.1 KII70872.1 - 0.08 12.5 0.1 17 5.0 0.0 2.3 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain DUF1379 PF07126.7 KII70872.1 - 0.11 11.8 1.9 11 5.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1379) Filament PF00038.16 KII70872.1 - 0.11 11.9 2.9 6.9 6.0 0.2 2.4 1 1 0 2 2 2 0 Intermediate filament protein CRAL_TRIO_N PF03765.10 KII70872.1 - 0.22 11.6 5.8 8.2 6.6 0.4 2.8 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain PurA PF04845.8 KII70873.1 - 8e-07 28.3 0.2 8.9e-07 28.2 0.1 1.1 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein PSI_PsaH PF03244.9 KII70873.1 - 0.069 12.3 0.0 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 Photosystem I reaction centre subunit VI VCBS PF13517.1 KII70875.1 - 5.5e-09 36.2 3.2 4.6e-07 30.0 0.2 2.0 1 1 2 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII70875.1 - 0.00025 20.6 8.9 0.0055 16.3 0.0 2.9 3 0 0 3 3 3 2 FG-GAP repeat Birna_VP5 PF03042.9 KII70879.1 - 0.072 12.5 0.0 0.098 12.1 0.0 1.2 1 0 0 1 1 1 0 Birnavirus VP5 protein Ras PF00071.17 KII70880.1 - 3.4e-58 195.5 1.5 4e-58 195.3 1.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII70880.1 - 2.4e-17 63.5 0.1 3.4e-17 63.0 0.1 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII70880.1 - 8.7e-13 47.8 0.2 1.2e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KII70880.1 - 1.7e-06 27.6 0.7 1.6e-05 24.4 0.5 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KII70880.1 - 2.1e-06 27.0 0.5 2.8e-06 26.6 0.3 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KII70880.1 - 5.1e-05 23.2 0.0 8.8e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 KII70880.1 - 0.00031 20.3 0.5 0.45 10.0 0.0 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein FeoB_N PF02421.13 KII70880.1 - 0.0092 15.2 0.1 0.49 9.6 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF3575 PF12099.3 KII70880.1 - 0.047 12.7 0.1 0.071 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3575) AAA_14 PF13173.1 KII70880.1 - 0.049 13.5 0.1 0.12 12.2 0.0 1.7 1 1 1 2 2 2 0 AAA domain SRPRB PF09439.5 KII70880.1 - 0.051 12.7 0.0 0.067 12.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_18 PF13238.1 KII70880.1 - 0.06 13.6 0.0 0.087 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 KII70880.1 - 0.062 12.4 0.1 0.13 11.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_15 PF13175.1 KII70880.1 - 0.082 11.9 0.5 0.092 11.7 0.3 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.2 KII70880.1 - 0.12 11.7 0.1 0.21 11.0 0.0 1.5 1 1 1 2 2 2 0 AAA-like domain HTH_23 PF13384.1 KII70882.1 - 6.2e-06 25.6 0.1 6.5e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain TrmB PF01978.14 KII70882.1 - 1.4e-05 24.7 0.1 4.7e-05 23.0 0.1 1.8 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_29 PF13551.1 KII70882.1 - 0.00011 22.3 0.0 0.00045 20.3 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_24 PF13412.1 KII70882.1 - 0.0022 17.3 0.3 0.0068 15.7 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.1 KII70882.1 - 0.0026 17.7 0.0 0.011 15.7 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.13 KII70882.1 - 0.032 13.9 0.2 0.052 13.2 0.1 1.4 1 1 0 1 1 1 0 'Paired box' domain DUF4106 PF13388.1 KII70882.1 - 0.068 12.1 0.1 1.9 7.3 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4106) Trp_repressor PF01371.14 KII70882.1 - 0.11 12.4 0.1 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Trp repressor protein RNA_pol_A_bac PF01000.21 KII70882.1 - 0.12 12.4 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb3/RpoA insert domain Fe_dep_repress PF01325.14 KII70882.1 - 0.13 12.2 0.1 0.64 10.0 0.0 2.2 1 1 2 3 3 3 0 Iron dependent repressor, N-terminal DNA binding domain Cnd3 PF12719.2 KII70883.1 - 3e-38 131.4 10.0 5.6e-38 130.6 6.9 1.4 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.17 KII70883.1 - 0.028 14.5 0.1 0.15 12.2 0.1 2.4 1 0 0 1 1 1 0 HEAT repeat RIH_assoc PF08454.6 KII70883.1 - 0.066 12.8 5.1 0.99 9.0 0.2 3.7 3 0 0 3 3 3 0 RyR and IP3R Homology associated Dimer_Tnp_hAT PF05699.9 KII70884.1 - 3.3e-07 29.8 0.2 5.3e-07 29.1 0.2 1.3 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region Ank_2 PF12796.2 KII70885.1 - 1.6e-16 60.4 0.1 1.1e-09 38.4 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KII70885.1 - 1.9e-08 33.7 0.1 0.093 13.0 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.25 KII70885.1 - 2e-08 33.6 0.0 0.28 11.0 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KII70885.1 - 5.3e-08 33.1 0.2 0.00018 21.9 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII70885.1 - 1.4e-07 31.4 0.2 0.9 9.8 0.0 4.5 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Notch PF00066.12 KII70885.1 - 1.1e-06 28.7 9.1 1.1e-06 28.7 6.3 2.7 3 0 0 3 3 3 1 LNR domain Ctr PF04145.10 KII70885.1 - 0.021 14.8 0.0 0.039 14.0 0.0 1.4 1 0 0 1 1 1 0 Ctr copper transporter family hEGF PF12661.2 KII70885.1 - 0.048 13.7 12.2 0.043 13.9 2.0 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_2 PF07974.8 KII70885.1 - 0.35 11.0 34.7 0.037 14.1 7.8 3.6 3 0 0 3 3 3 0 EGF-like domain Vpu PF00558.14 KII70885.1 - 2.3 7.8 5.7 0.29 10.7 0.9 1.7 2 0 0 2 2 2 0 Vpu protein SNF5 PF04855.7 KII70886.1 - 3.3e-20 72.5 0.6 1e-18 67.7 0.4 2.2 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 HD_5 PF13487.1 KII70887.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 HD domain DDE_Tnp_IS1595 PF12762.2 KII70888.1 - 3.4e-12 46.4 0.0 4.9e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain AAA_18 PF13238.1 KII70889.1 - 0.026 14.8 0.3 0.039 14.2 0.2 1.3 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 KII70890.1 - 1.8e-109 364.2 0.0 2.8e-109 363.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KII70890.1 - 4e-17 62.7 2.1 8.6e-17 61.6 1.4 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain AAA_14 PF13173.1 KII70890.1 - 0.016 15.0 0.0 0.057 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 KII70890.1 - 0.044 14.0 0.3 0.39 11.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KII70890.1 - 0.061 13.3 0.0 1.1 9.2 0.0 2.5 2 1 1 3 3 3 0 AAA ATPase domain DEAD_assoc PF08494.6 KII70890.1 - 0.1 12.2 0.1 0.24 11.1 0.1 1.6 1 0 0 1 1 1 0 DEAD/H associated SNF PF00209.13 KII70890.1 - 0.14 10.5 0.0 0.23 9.8 0.0 1.2 1 0 0 1 1 1 0 Sodium:neurotransmitter symporter family bZIP_1 PF00170.16 KII70891.1 - 2.2e-08 33.9 3.4 3.5e-08 33.2 2.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KII70891.1 - 0.0007 19.3 6.2 0.0015 18.3 4.3 1.5 1 0 0 1 1 1 1 Basic region leucine zipper YARHG PF13308.1 KII70891.1 - 0.0049 16.3 0.7 0.0085 15.6 0.3 1.6 2 0 0 2 2 2 1 YARHG domain Meiosis_expr PF15163.1 KII70891.1 - 0.066 13.5 1.2 0.22 11.8 0.5 2.0 1 1 1 2 2 2 0 Meiosis-expressed CCT PF06203.9 KII70891.1 - 0.57 9.8 10.9 2.2 7.9 0.1 2.3 1 1 1 2 2 2 0 CCT motif RRM_1 PF00076.17 KII70892.1 - 1.3e-51 172.0 0.2 8.2e-18 63.8 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII70892.1 - 1.6e-37 127.2 0.1 1.1e-13 50.9 0.0 3.5 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII70892.1 - 3.8e-28 97.0 3.9 8.9e-09 35.0 0.2 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII70892.1 - 9.9e-05 22.1 1.4 0.18 11.6 0.0 3.1 4 0 0 4 4 4 2 RNA binding motif Nup35_RRM PF05172.8 KII70892.1 - 0.00074 19.2 0.2 0.46 10.2 0.1 3.2 2 1 1 3 3 3 2 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 KII70892.1 - 0.028 14.1 0.2 0.4 10.4 0.0 2.8 3 0 0 3 3 3 0 Limkain b1 RNA_pol_Rpb4 PF03874.11 KII70892.1 - 0.065 13.2 0.8 0.23 11.4 0.3 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb4 Adaptin_N PF01602.15 KII70893.1 - 3.9e-79 266.3 5.3 5.7e-79 265.8 3.7 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 KII70893.1 - 1.8e-05 24.9 2.8 4e-05 23.9 1.9 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain DUF3135 PF11333.3 KII70893.1 - 0.0095 16.0 0.0 0.51 10.5 0.0 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3135) Cnd1 PF12717.2 KII70893.1 - 1.6 8.5 9.3 1.2 8.9 0.1 3.8 1 1 2 3 3 3 0 non-SMC mitotic condensation complex subunit 1 XPC-binding PF09280.6 KII70893.1 - 2.2 7.8 7.7 0.29 10.6 0.7 2.9 4 0 0 4 4 4 0 XPC-binding domain Formyl_trans_N PF00551.14 KII70894.1 - 9e-19 67.7 0.0 1.5e-18 66.9 0.0 1.4 1 1 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.13 KII70895.1 - 1.7e-11 44.0 0.0 2.3e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain DAGK_cat PF00781.19 KII70896.1 - 8.1e-17 60.8 0.0 1.3e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.16 KII70896.1 - 0.0074 15.1 0.0 0.013 14.2 0.0 1.4 1 0 0 1 1 1 1 ATP-NAD kinase PUF PF00806.14 KII70897.1 - 7.5e-62 201.4 14.4 2.1e-08 33.1 0.0 8.9 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat TAN PF11640.3 KII70897.1 - 0.018 14.7 0.9 4.3 7.0 0.1 3.6 3 1 0 3 3 3 0 Telomere-length maintenance and DNA damage repair Erf4 PF10256.4 KII70897.1 - 0.066 13.0 2.8 0.22 11.4 0.3 2.7 2 1 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family Pyrophosphatase PF00719.14 KII70899.1 - 1.1e-47 161.3 0.0 1.5e-47 160.9 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase OpcA PF07239.6 KII70899.1 - 0.0068 15.3 0.0 0.44 9.4 0.0 2.1 2 0 0 2 2 2 2 Outer membrane protein OpcA GAGA_bind PF06217.7 KII70900.1 - 0.048 13.6 5.2 0.06 13.3 3.6 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family FAM176 PF14851.1 KII70900.1 - 0.54 9.9 3.3 12 5.5 0.1 2.2 2 0 0 2 2 2 0 FAM176 family Macoilin PF09726.4 KII70900.1 - 0.79 7.9 15.0 0.98 7.6 10.4 1.1 1 0 0 1 1 1 0 Transmembrane protein SOBP PF15279.1 KII70900.1 - 2.2 8.5 12.3 2.8 8.2 8.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DNA_pol_viral_N PF00242.12 KII70900.1 - 4.1 6.3 15.2 5.7 5.8 10.5 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain SelP_N PF04592.9 KII70902.1 - 0.078 12.3 1.3 0.12 11.7 0.9 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF572 PF04502.8 KII70902.1 - 0.16 11.1 6.4 0.21 10.7 4.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Presenilin PF01080.12 KII70902.1 - 9.5 4.9 7.7 13 4.4 5.3 1.2 1 0 0 1 1 1 0 Presenilin DUF1664 PF07889.7 KII70908.1 - 7.2e-05 22.5 11.2 0.0037 17.0 2.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) AAA_13 PF13166.1 KII70908.1 - 0.00088 17.8 13.8 0.001 17.6 9.6 1.0 1 0 0 1 1 1 1 AAA domain IncA PF04156.9 KII70908.1 - 0.0021 17.7 13.5 0.26 10.8 9.1 2.1 1 1 0 1 1 1 1 IncA protein Laminin_II PF06009.7 KII70908.1 - 0.032 13.9 8.1 0.052 13.3 3.4 2.3 1 1 1 2 2 2 0 Laminin Domain II TBPIP PF07106.8 KII70908.1 - 0.086 12.3 17.0 0.078 12.5 4.7 2.8 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ISG65-75 PF11727.3 KII70908.1 - 0.11 11.4 4.8 0.16 10.9 3.3 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein Mad3_BUB1_I PF08311.7 KII70908.1 - 0.13 12.0 2.5 0.34 10.6 0.7 2.2 1 1 1 2 2 2 0 Mad3/BUB1 homology region 1 Occludin_ELL PF07303.8 KII70908.1 - 0.13 12.9 6.2 1.6 9.5 0.5 2.8 1 1 2 3 3 3 0 Occludin homology domain DUF4200 PF13863.1 KII70908.1 - 0.14 12.1 16.6 0.34 10.8 1.7 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Syntaxin_2 PF14523.1 KII70908.1 - 0.14 12.1 13.9 6.2 6.9 8.1 2.9 1 1 2 3 3 3 0 Syntaxin-like protein NPV_P10 PF05531.7 KII70908.1 - 0.16 12.2 14.6 0.12 12.6 1.2 3.1 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4347 PF14252.1 KII70908.1 - 0.16 11.4 0.7 0.45 10.0 0.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4347) WHEP-TRS PF00458.15 KII70908.1 - 0.17 11.5 1.4 0.39 10.4 1.0 1.6 1 0 0 1 1 1 0 WHEP-TRS domain Spectrin PF00435.16 KII70908.1 - 0.19 12.0 9.1 2.6 8.3 1.4 2.4 1 1 1 2 2 2 0 Spectrin repeat CENP-F_leu_zip PF10473.4 KII70908.1 - 0.23 11.3 10.8 0.15 11.8 1.8 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V-SNARE PF05008.10 KII70908.1 - 0.31 11.2 7.4 0.33 11.1 0.9 2.6 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus TPR_MLP1_2 PF07926.7 KII70908.1 - 0.33 10.7 10.2 0.097 12.4 3.8 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein COG2 PF06148.6 KII70908.1 - 0.35 10.7 10.2 0.8 9.5 0.3 3.0 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ADIP PF11559.3 KII70908.1 - 0.47 10.3 10.8 0.099 12.5 1.6 2.1 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF885 PF05960.6 KII70908.1 - 0.51 9.4 3.4 0.55 9.3 2.3 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Cation_efflux PF01545.16 KII70908.1 - 0.54 9.2 2.5 0.72 8.8 1.7 1.2 1 0 0 1 1 1 0 Cation efflux family DUF148 PF02520.12 KII70908.1 - 0.68 9.7 8.8 0.29 10.9 2.8 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF148 Laminin_I PF06008.9 KII70908.1 - 0.82 8.9 9.6 1.1 8.5 1.6 2.1 1 1 0 2 2 2 0 Laminin Domain I DUF972 PF06156.8 KII70908.1 - 0.94 9.8 8.5 6.4 7.1 0.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) FliJ PF02050.11 KII70908.1 - 1 9.3 5.6 2.4 8.2 0.5 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein Spore_II_R PF09551.5 KII70908.1 - 1.3 9.0 7.8 7.2 6.6 0.3 2.2 1 1 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) DUF711 PF05167.7 KII70908.1 - 1.3 7.6 6.2 3.3 6.3 4.3 1.7 1 1 0 1 1 1 0 Uncharacterised ACR (DUF711) Phage_GP20 PF06810.6 KII70908.1 - 1.6 8.1 14.5 4.8 6.5 3.5 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF3375 PF11855.3 KII70908.1 - 1.7 7.2 8.3 0.75 8.4 3.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3375) Nsp1_C PF05064.8 KII70908.1 - 2.5 7.7 8.7 6.2 6.4 0.4 2.7 1 1 1 3 3 3 0 Nsp1-like C-terminal region DUF3510 PF12022.3 KII70908.1 - 2.8 8.0 10.1 4.4 7.4 2.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3510) DUF2216 PF10226.4 KII70908.1 - 3.7 7.0 9.5 25 4.2 6.6 2.1 1 1 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) TMPIT PF07851.8 KII70908.1 - 4.1 6.3 8.5 1.9 7.5 4.1 1.6 1 1 1 2 2 2 0 TMPIT-like protein FlaC_arch PF05377.6 KII70908.1 - 4.5 7.2 13.7 0.75 9.7 0.1 3.9 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) Sas10_Utp3 PF04000.10 KII70908.1 - 4.7 7.4 7.1 12 6.2 0.4 2.8 3 1 0 3 3 2 0 Sas10/Utp3/C1D family CR6_interact PF10147.4 KII70908.1 - 4.8 6.4 7.5 3.6 6.8 0.5 2.2 1 1 1 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Snf7 PF03357.16 KII70908.1 - 6.4 6.1 12.3 2 7.7 5.3 2.2 2 1 0 2 2 2 0 Snf7 Seryl_tRNA_N PF02403.17 KII70908.1 - 7.6 6.5 15.3 38 4.3 2.9 2.8 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.10 KII70908.1 - 8.1 6.0 12.3 1.5 8.3 1.0 2.8 2 1 1 3 3 3 0 Septum formation initiator DUF2203 PF09969.4 KII70908.1 - 9.8 6.4 7.9 11 6.3 0.4 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF1856 PF08983.5 KII70909.1 - 0.78 9.8 6.4 8.2 6.6 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1856) Lysyl_oxidase PF01186.12 KII70910.1 - 0.028 14.0 0.0 0.035 13.7 0.0 1.1 1 0 0 1 1 1 0 Lysyl oxidase Legionella_OMP PF05150.7 KII70910.1 - 0.065 12.3 0.1 0.073 12.1 0.0 1.1 1 0 0 1 1 1 0 Legionella pneumophila major outer membrane protein precursor DUF2396 PF09654.5 KII70911.1 - 0.016 15.1 0.4 0.024 14.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2396) dDENN PF03455.14 KII70912.1 - 0.069 13.2 0.2 12 6.0 0.0 2.5 2 0 0 2 2 2 0 dDENN domain PIP5K PF01504.13 KII70914.1 - 3.2e-10 39.5 0.2 4.8e-10 38.9 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF460 PF04312.8 KII70915.1 - 0.0047 16.4 0.2 0.008 15.7 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF460) Arg_repressor_C PF02863.13 KII70915.1 - 0.018 14.5 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain DUF4358 PF14270.1 KII70915.1 - 0.062 13.1 0.2 0.079 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4358) THUMP PF02926.12 KII70916.1 - 0.0007 19.4 0.7 0.014 15.2 0.2 2.1 1 1 1 2 2 2 2 THUMP domain DDE_3 PF13358.1 KII70917.1 - 3.8e-08 33.2 0.0 4.4e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 KII70918.1 - 3.9e-12 45.3 0.5 4.2e-08 32.5 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII70918.1 - 2.3e-10 40.2 0.3 5.2e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_29 PF13551.1 KII70918.1 - 3.1e-09 36.9 0.5 9.1e-09 35.4 0.2 1.7 1 1 1 2 2 2 1 Winged helix-turn helix PAX PF00292.13 KII70918.1 - 4.4e-08 32.8 0.2 5.6e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_38 PF13936.1 KII70918.1 - 7e-07 28.6 1.3 5e-05 22.7 0.4 2.7 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.1 KII70918.1 - 2.5e-06 26.5 1.7 3.9e-05 22.7 0.0 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 DUF1323 PF07037.6 KII70918.1 - 7.1e-06 26.2 0.3 1.4e-05 25.2 0.2 1.6 1 1 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_Tnp_1 PF01527.15 KII70918.1 - 1.7e-05 24.7 0.2 2.9e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Transposase HTH_Tnp_IS630 PF01710.11 KII70918.1 - 2.1e-05 24.1 0.2 3.2e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Transposase Bot1p PF12298.3 KII70918.1 - 2.4e-05 24.3 1.1 2.9e-05 24.0 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein HTH_32 PF13565.1 KII70918.1 - 2.6e-05 24.9 0.4 0.00039 21.1 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.8 KII70918.1 - 3e-05 23.3 0.9 0.00012 21.4 0.1 2.2 2 1 1 3 3 2 1 CENP-B N-terminal DNA-binding domain HTH_33 PF13592.1 KII70918.1 - 0.00018 20.9 0.0 0.00041 19.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_24 PF13412.1 KII70918.1 - 0.00018 20.7 0.4 0.097 12.0 0.1 2.4 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Tnp_Tc3_2 PF01498.13 KII70918.1 - 0.0002 21.3 0.8 0.0035 17.3 0.0 2.4 2 1 0 2 2 2 1 Transposase Arg_repressor PF01316.16 KII70918.1 - 0.00045 19.7 1.1 0.00086 18.8 0.0 1.9 2 1 1 3 3 3 1 Arginine repressor, DNA binding domain LacI PF00356.16 KII70918.1 - 0.00046 19.7 1.0 1.3 8.6 0.0 3.7 4 0 0 4 4 4 1 Bacterial regulatory proteins, lacI family HTH_17 PF12728.2 KII70918.1 - 0.00091 19.4 0.0 0.2 11.9 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.17 KII70918.1 - 0.0012 18.6 0.0 0.019 14.8 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.1 KII70918.1 - 0.002 17.8 0.6 0.091 12.5 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.10 KII70918.1 - 0.004 16.9 1.7 0.21 11.4 0.2 2.6 2 2 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_40 PF14493.1 KII70918.1 - 0.0054 16.9 0.1 0.011 15.9 0.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 KII70918.1 - 0.0082 15.8 0.2 0.056 13.1 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB SpoIIID PF12116.3 KII70918.1 - 0.016 15.1 1.3 0.18 11.7 0.7 2.3 1 1 0 1 1 1 0 Stage III sporulation protein D Sigma70_r4 PF04545.11 KII70918.1 - 0.021 14.1 0.1 0.05 12.9 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 DUF2666 PF10869.3 KII70918.1 - 0.022 14.8 0.1 0.027 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) HTH_psq PF05225.11 KII70918.1 - 0.028 13.9 0.0 0.064 12.8 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_DeoR PF08220.7 KII70918.1 - 0.032 13.7 0.9 0.2 11.2 0.1 2.3 2 1 0 2 2 2 0 DeoR-like helix-turn-helix domain Sigma70_r4_2 PF08281.7 KII70918.1 - 0.032 13.6 0.0 0.28 10.6 0.0 2.2 2 1 0 2 2 2 0 Sigma-70, region 4 MCR_C PF04609.7 KII70918.1 - 0.033 13.0 0.7 0.038 12.7 0.5 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C HTH_11 PF08279.7 KII70918.1 - 0.038 13.6 1.0 0.096 12.3 0.0 2.2 3 0 0 3 3 2 0 HTH domain Prenyltransf PF01255.14 KII70918.1 - 0.078 12.0 0.2 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase HTH_WhiA PF02650.9 KII70918.1 - 0.09 13.1 0.1 0.86 10.0 0.0 2.0 2 0 0 2 2 2 0 WhiA C-terminal HTH domain FliG_N PF14842.1 KII70918.1 - 0.095 12.8 0.0 0.28 11.2 0.0 1.9 1 1 1 2 2 2 0 FliG N-terminal domain TFIIE_beta PF02186.10 KII70918.1 - 0.099 12.6 0.4 0.22 11.5 0.1 1.7 2 0 0 2 2 2 0 TFIIE beta subunit core domain MarR_2 PF12802.2 KII70918.1 - 0.13 11.9 0.0 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 MarR family zf-C2H2_4 PF13894.1 KII70920.1 - 2 8.9 9.6 0.27 11.6 1.6 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger fn3 PF00041.16 KII70921.1 - 0.011 15.8 0.0 1.8 8.7 0.0 3.1 3 0 0 3 3 3 0 Fibronectin type III domain DDE_3 PF13358.1 KII70923.1 - 8e-06 25.6 0.0 1.2e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease NPR3 PF03666.8 KII70924.1 - 0.08 11.4 0.3 0.095 11.2 0.1 1.3 1 1 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Sugar_tr PF00083.19 KII70927.1 - 4.4e-05 22.2 0.4 4.4e-05 22.2 0.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII70927.1 - 7.2e-05 21.6 3.8 8.3e-05 21.4 2.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MULE PF10551.4 KII70929.1 - 0.00066 19.7 0.1 0.0013 18.8 0.1 1.6 1 0 0 1 1 1 1 MULE transposase domain Peptidase_C50 PF03568.12 KII70930.1 - 1.9e-50 171.6 0.1 2.3e-50 171.4 0.1 1.1 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.2 KII70930.1 - 0.15 11.2 0.0 0.27 10.3 0.0 1.4 1 1 0 1 1 1 0 CHAT domain Peptidase_C50 PF03568.12 KII70931.1 - 2.5e-05 23.1 0.1 4.8e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C50 DUF725 PF05267.7 KII70932.1 - 0.41 10.5 3.9 0.41 10.5 0.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF725) Phage_F PF02305.12 KII70933.1 - 0.087 11.3 0.1 0.1 11.0 0.0 1.0 1 0 0 1 1 1 0 Capsid protein (F protein) Pinin_SDK_memA PF04696.8 KII70935.1 - 0.04 13.5 0.4 0.057 13.0 0.3 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region Sec62 PF03839.11 KII70936.1 - 0.04 13.3 0.2 0.045 13.1 0.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 6PGD PF00393.14 KII70939.1 - 3.2e-85 285.8 0.2 4e-85 285.5 0.1 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 KII70939.1 - 4.2e-31 107.9 0.0 6.8e-31 107.3 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 KII70939.1 - 0.084 12.9 0.0 0.5 10.4 0.0 2.1 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase WD40 PF00400.27 KII70940.1 - 6.8e-11 41.6 2.7 5.2e-07 29.2 0.7 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat PBP1_TM PF14812.1 KII70941.1 - 0.024 14.9 0.2 0.045 14.0 0.1 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal 6PGD PF00393.14 KII70942.1 - 4.4e-85 285.4 0.2 5.7e-85 285.0 0.1 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 KII70942.1 - 1.6e-49 167.8 0.0 2.3e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.15 KII70942.1 - 0.00025 21.1 0.0 0.00044 20.3 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 KII70942.1 - 0.0012 19.2 0.0 0.0023 18.2 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 KII70942.1 - 0.099 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_11 PF14833.1 KII70942.1 - 0.11 12.5 0.0 0.59 10.1 0.0 2.1 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PGK PF00162.14 KII70942.1 - 0.14 10.6 0.6 0.38 9.2 0.0 1.9 3 0 0 3 3 3 0 Phosphoglycerate kinase DUF228 PF02989.9 KII70943.1 - 0.12 11.9 0.2 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 Lyme disease proteins of unknown function EMP24_GP25L PF01105.19 KII70943.1 - 0.12 12.1 0.4 0.29 10.8 0.3 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF2909 PF11137.3 KII70943.1 - 0.19 11.4 1.6 0.85 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) MLANA PF14991.1 KII70943.1 - 0.31 11.0 1.0 0.62 10.0 0.1 1.9 2 0 0 2 2 2 0 Protein melan-A DUF3753 PF12575.3 KII70943.1 - 0.94 9.3 3.7 0.27 11.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) Mucin PF01456.12 KII70943.1 - 1.4 8.6 6.3 0.15 11.7 0.2 2.1 2 1 0 2 2 2 0 Mucin-like glycoprotein DUF2897 PF11446.3 KII70943.1 - 2.9 7.7 4.4 6.6 6.6 3.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) DUF1620 PF07774.8 KII70946.1 - 9.6e-14 51.1 2.0 9.6e-14 51.1 1.4 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 KII70946.1 - 0.063 12.7 0.0 0.73 9.2 0.0 2.6 3 1 0 3 3 3 0 PQQ-like domain Fork_head PF00250.13 KII70947.1 - 2.4e-24 85.1 1.0 1.6e-23 82.5 0.5 2.5 2 0 0 2 2 2 1 Fork head domain DDE_3 PF13358.1 KII70948.1 - 3.7e-21 75.3 0.0 7.2e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII70948.1 - 0.027 14.0 0.0 0.1 12.1 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn helix DnaJ PF00226.26 KII70950.1 - 1.1e-12 47.5 0.2 1.1e-12 47.5 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain DUF607 PF04678.8 KII70951.1 - 4.3e-32 111.4 3.8 4.7e-32 111.3 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF607 DUF2157 PF09925.4 KII70951.1 - 0.024 14.2 0.0 0.03 13.9 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF1129 PF06570.6 KII70951.1 - 0.052 12.8 0.5 0.06 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Sigma_reg_C PF13791.1 KII70951.1 - 0.079 12.9 5.0 0.11 12.5 3.2 1.4 1 1 0 1 1 1 0 Sigma factor regulator C-terminal DUF2018 PF09442.5 KII70951.1 - 0.68 10.5 3.7 3.5 8.2 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2018) Tetraspannin PF00335.15 KII70954.1 - 3.2e-14 52.7 16.8 4.5e-14 52.2 11.7 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF3402 PF11882.3 KII70954.1 - 0.12 11.3 0.1 0.21 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) rve PF00665.21 KII70955.1 - 1.6e-21 76.6 0.1 2.3e-21 76.1 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII70955.1 - 5.2e-05 22.6 0.0 0.00012 21.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII70955.1 - 0.00014 21.5 0.1 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Nepo_coat_N PF03689.10 KII70955.1 - 0.011 15.4 0.1 0.094 12.4 0.0 2.3 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain DUF1796 PF08795.5 KII70955.1 - 0.057 13.0 0.1 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) DUF3886 PF13025.1 KII70956.1 - 0.0098 15.8 4.1 0.013 15.4 2.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3886) Rpn3_C PF08375.6 KII70956.1 - 0.16 12.4 2.8 0.22 11.9 1.9 1.2 1 0 0 1 1 1 0 Proteasome regulatory subunit C-terminal WBP-1 PF11669.3 KII70956.1 - 0.16 12.0 1.8 21 5.2 0.0 2.2 2 0 0 2 2 2 0 WW domain-binding protein 1 Glycoprotein_B PF00606.13 KII70956.1 - 0.33 8.9 5.2 0.52 8.2 3.6 1.2 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B E1-E2_ATPase PF00122.15 KII70956.1 - 0.4 9.6 3.0 1.3 7.9 2.2 1.7 1 1 1 2 2 2 0 E1-E2 ATPase COPI_assoc PF08507.5 KII70956.1 - 0.65 9.6 11.3 1.5 8.4 7.8 1.6 1 1 0 1 1 1 0 COPI associated protein MFS_1 PF07690.11 KII70956.1 - 0.86 8.2 15.3 1.4 7.5 10.6 1.5 1 1 0 1 1 1 0 Major Facilitator Superfamily DctQ PF04290.7 KII70956.1 - 5.2 6.8 9.3 10 5.8 6.5 1.5 1 1 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component CopD PF05425.8 KII70956.1 - 6 7.1 10.3 1.4e+02 2.7 8.0 2.0 1 1 1 2 2 2 0 Copper resistance protein D Bystin PF05291.6 KII70957.1 - 1.3e-29 103.1 2.7 1.4e-29 103.0 1.9 1.0 1 0 0 1 1 1 1 Bystin Bystin PF05291.6 KII70958.1 - 1.7e-20 73.2 0.0 1.7e-20 73.2 0.0 1.9 2 0 0 2 2 2 1 Bystin DUF4162 PF13732.1 KII70958.1 - 6.5 7.3 8.6 2.9 8.4 3.1 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4162) Hexokinase_2 PF03727.11 KII70959.1 - 1.1e-42 145.9 2.4 2.1e-37 128.6 0.1 2.5 2 1 1 3 3 3 2 Hexokinase RNA_pol_Rpb1_6 PF04992.9 KII70959.1 - 0.051 13.3 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 FancD2 PF14631.1 KII70960.1 - 6.4e-12 43.4 4.7 7.2e-12 43.3 3.2 1.0 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease zf-CCHC PF00098.18 KII70963.1 - 2e-06 27.4 2.8 3.1e-06 26.8 2.0 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.1 KII70963.1 - 0.053 13.0 1.6 0.089 12.2 1.1 1.3 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 KII70963.1 - 0.076 12.6 1.0 0.2 11.3 0.3 1.9 2 0 0 2 2 2 0 Zinc knuckle UCH PF00443.24 KII70965.1 - 3.2e-41 141.2 0.2 4.8e-41 140.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 KII70965.1 - 5e-14 52.1 1.3 9.2e-13 48.1 0.1 2.8 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 KII70965.1 - 2.8e-11 43.4 1.6 4.9e-09 36.0 0.3 3.0 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.26 KII70965.1 - 6.5e-11 41.7 0.0 8.2e-07 28.6 0.0 2.6 2 0 0 2 2 2 2 UBA/TS-N domain DDE_3 PF13358.1 KII70967.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease MULE PF10551.4 KII70968.1 - 9.5e-08 32.1 0.1 1.7e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_IS1595 PF12762.2 KII70969.1 - 3.9e-15 55.9 0.1 8.5e-14 51.6 0.1 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII70970.1 - 1e-17 64.3 0.0 1.1e-17 64.2 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII70971.1 - 3.2e-10 39.9 0.0 4.6e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RNA_pol_Rpc34 PF05158.7 KII70973.1 - 1.5e-22 80.2 0.0 1.9e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.6 KII70973.1 - 0.0098 16.2 0.1 2.3 8.7 0.0 2.8 3 0 0 3 3 3 1 Replication protein A C terminal TACI-CRD2 PF09305.5 KII70973.1 - 0.087 12.6 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 TACI, cysteine-rich domain Papo_T_antigen PF02380.10 KII70976.1 - 0.051 13.4 0.1 0.072 13.0 0.1 1.2 1 0 0 1 1 1 0 T-antigen specific domain Csm1 PF12539.3 KII70977.1 - 0.026 14.9 0.2 0.097 13.1 0.1 2.0 1 0 0 1 1 1 0 Chromosome segregation protein Csm1/Pcs1 Pkinase PF00069.20 KII70979.1 - 1.9e-32 112.4 0.0 4.8e-32 111.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII70979.1 - 5.3e-16 58.4 0.0 8.2e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TraC_F_IV PF11130.3 KII70979.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer ER_lumen_recept PF00810.13 KII70980.1 - 2.5e-52 177.2 13.0 4.3e-52 176.5 9.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.9 KII70980.1 - 0.0039 16.6 1.9 0.0039 16.6 1.3 3.7 5 0 0 5 5 5 2 PQ loop repeat Phage_BR0599 PF09356.5 KII70981.1 - 0.01 15.9 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 0 Phage conserved hypothetical protein BR0599 NTP_transferase PF00483.18 KII70984.1 - 1.6e-34 119.3 0.0 2.2e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 KII70984.1 - 2.4e-08 34.2 0.0 4.4e-08 33.3 0.0 1.4 1 1 0 1 1 1 1 MobA-like NTP transferase domain CBS PF00571.23 KII70984.1 - 0.017 14.9 0.0 0.061 13.1 0.0 2.0 2 0 0 2 2 2 0 CBS domain CTP_transf_3 PF02348.14 KII70985.1 - 2.5e-22 79.6 0.0 2.9e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase PAPS_reduct PF01507.14 KII70986.1 - 0.0038 17.0 0.0 0.0054 16.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.15 KII70986.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 PP-loop family KH_1 PF00013.24 KII70986.1 - 0.12 12.0 0.1 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 KH domain MAF_flag10 PF01973.13 KII70987.1 - 1.1e-32 112.8 0.4 2.3e-32 111.8 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function DUF115 Ldl_recept_a PF00057.13 KII70988.1 - 9.3e-09 35.0 11.8 9.3e-09 35.0 8.2 2.3 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII70989.1 - 0.0074 15.9 2.0 2.5 8.2 0.2 2.8 2 0 0 2 2 2 2 BNR/Asp-box repeat OATP PF03137.15 KII70991.1 - 2.6e-51 174.2 24.3 1.8e-50 171.5 16.9 2.0 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 KII70991.1 - 5.9e-13 48.2 10.6 5.9e-13 48.2 7.3 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.10 KII70991.1 - 0.17 11.8 7.4 0.068 13.1 2.7 2.1 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.16 KII70991.1 - 1 9.4 5.7 2.9 7.9 4.0 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain HAMP PF00672.20 KII70991.1 - 2.3 8.4 4.6 1 9.5 0.2 2.6 3 0 0 3 3 3 0 HAMP domain ETRAMP PF09716.5 KII70992.1 - 0.00067 19.5 1.4 0.00081 19.2 1.0 1.5 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) DUF1469 PF07332.6 KII70992.1 - 0.12 12.1 0.1 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) CD34_antigen PF06365.7 KII70992.1 - 0.12 11.9 1.0 0.17 11.4 0.7 1.3 1 1 0 1 1 1 0 CD34/Podocalyxin family Ldl_recept_a PF00057.13 KII70996.1 - 2.4e-05 24.1 15.0 2.4e-05 24.1 10.4 3.1 4 0 0 4 4 4 1 Low-density lipoprotein receptor domain class A MNE1 PF13762.1 KII70997.1 - 0.012 15.7 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component Ldl_recept_a PF00057.13 KII70999.1 - 1.1e-07 31.6 13.4 1.1e-07 31.6 9.3 2.7 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A PAD_N PF08526.5 KII71000.1 - 0.048 13.7 0.0 0.08 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) N-terminal domain rve PF00665.21 KII71001.1 - 1e-07 32.0 0.0 1.8e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71001.1 - 9.2e-05 21.8 0.0 0.00019 20.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Vasohibin PF14822.1 KII71002.1 - 0.021 13.9 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Vasohibin SNAP PF14938.1 KII71004.1 - 4.3e-08 32.6 0.6 3.2e-07 29.7 0.0 2.0 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP DUF2242 PF10001.4 KII71004.1 - 0.14 12.0 0.7 0.44 10.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2242) Lustrin_cystein PF14625.1 KII71005.1 - 0.11 12.6 0.8 0.16 12.0 0.6 1.2 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain FANCI_S3 PF14677.1 KII71010.1 - 0.073 12.4 0.2 0.12 11.7 0.1 1.4 1 1 0 1 1 1 0 FANCI solenoid 3 FANCI_S3 PF14677.1 KII71011.1 - 0.069 12.5 0.2 0.11 11.8 0.1 1.4 1 1 0 1 1 1 0 FANCI solenoid 3 Annexin PF00191.15 KII71012.1 - 0.076 12.9 0.1 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 Annexin Fimbrial PF00419.15 KII71013.1 - 2.7e-18 66.5 11.4 3.8e-18 66.0 7.9 1.2 1 0 0 1 1 1 1 Fimbrial protein DUF2518 PF10726.4 KII71013.1 - 0.032 13.7 0.1 0.17 11.4 0.0 2.0 1 1 1 2 2 2 0 Protein of function (DUF2518) OCC1 PF15506.1 KII71013.1 - 0.065 13.1 0.2 0.15 11.9 0.1 1.7 1 0 0 1 1 1 0 OCC1 family OEP PF02321.13 KII71014.1 - 8.1e-56 188.5 35.4 4e-29 101.5 8.2 2.0 2 0 0 2 2 2 2 Outer membrane efflux protein DUF3601 PF12208.3 KII71014.1 - 0.053 13.4 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3601) Ldl_recept_a PF00057.13 KII71015.1 - 2.2e-08 33.8 12.4 2.2e-08 33.8 8.6 2.7 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A DNA_pol_B_thumb PF14791.1 KII71017.1 - 0.071 12.8 0.8 0.34 10.6 0.0 2.3 2 1 0 2 2 2 0 DNA polymerase beta thumb rve PF00665.21 KII71020.1 - 2.4e-16 59.9 0.0 2.8e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71020.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS1595 PF12762.2 KII71021.1 - 9.3e-07 28.7 0.0 1.9e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain Elongin_A PF06881.6 KII71021.1 - 0.36 11.2 2.3 8.3 6.8 0.3 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Mer2 PF09074.5 KII71022.1 - 0.075 12.9 3.6 0.14 12.0 2.5 1.4 1 0 0 1 1 1 0 Mer2 rve PF00665.21 KII71023.1 - 1.3e-13 51.1 0.0 6.7e-13 48.8 0.0 2.2 2 1 1 3 3 3 1 Integrase core domain Asp_protease_2 PF13650.1 KII71023.1 - 1.6e-05 25.3 0.0 0.00011 22.6 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KII71023.1 - 6.4e-05 22.6 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease bZIP_1 PF00170.16 KII71025.1 - 4.3e-08 32.9 3.9 6.9e-08 32.3 2.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KII71025.1 - 0.0012 18.6 6.7 0.0026 17.5 4.6 1.5 1 0 0 1 1 1 1 Basic region leucine zipper YARHG PF13308.1 KII71025.1 - 0.0081 15.6 0.7 0.014 14.8 0.3 1.6 2 0 0 2 2 2 1 YARHG domain Meiosis_expr PF15163.1 KII71025.1 - 0.05 13.9 1.0 0.17 12.2 0.5 2.0 1 1 1 2 2 2 0 Meiosis-expressed CCT PF06203.9 KII71025.1 - 1.4 8.6 12.4 2.1 8.0 0.1 2.3 1 1 1 2 2 2 0 CCT motif DUF1029 PF06269.7 KII71026.1 - 0.14 12.1 5.4 0.35 10.8 3.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1029) Cytochrom_B561 PF03188.11 KII71027.1 - 0.0085 15.9 4.3 0.0085 15.9 3.0 1.9 1 1 0 2 2 2 1 Eukaryotic cytochrome b561 SUR7 PF06687.7 KII71027.1 - 1.2 8.7 12.0 0.48 9.9 2.8 2.1 2 0 0 2 2 2 0 SUR7/PalI family DUF1673 PF07895.6 KII71027.1 - 1.8 8.0 12.5 2.3 7.6 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) DUF3671 PF12420.3 KII71027.1 - 2.2 8.3 12.8 0.75 9.8 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF4131 PF13567.1 KII71027.1 - 8.3 5.7 7.6 26 4.1 5.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DDE_Tnp_IS1595 PF12762.2 KII71028.1 - 0.011 15.6 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain zf-Sec23_Sec24 PF04810.10 KII71029.1 - 0.1 12.1 0.6 0.1 12.1 0.4 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger DDE_3 PF13358.1 KII71030.1 - 4e-11 42.8 0.2 4.3e-11 42.7 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease GldH_lipo PF14109.1 KII71030.1 - 0.06 13.5 0.0 0.079 13.1 0.0 1.2 1 0 0 1 1 1 0 GldH lipoprotein DDE_1 PF03184.14 KII71030.1 - 0.097 11.7 0.1 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Activin_recp PF01064.18 KII71031.1 - 1.7e-07 31.7 12.4 2.1e-07 31.4 8.6 1.1 1 0 0 1 1 1 1 Activin types I and II receptor domain Dickkopf_N PF04706.7 KII71031.1 - 8 6.7 12.6 0.3 11.3 1.8 2.6 2 1 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region Hexokinase_1 PF00349.16 KII71034.1 - 1.7e-14 53.6 0.0 1.9e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 KII71035.1 - 1.5e-53 181.5 0.0 1.8e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII71035.1 - 3.4e-20 72.2 0.0 5.5e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase DUF3966 PF13110.1 KII71036.1 - 0.15 11.8 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3966) GATA PF00320.22 KII71036.1 - 2.5 7.5 8.2 0.094 12.0 1.0 2.0 2 0 0 2 2 2 0 GATA zinc finger RRN7 PF11781.3 KII71036.1 - 3.9 7.0 6.6 2.6 7.5 0.0 2.7 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 WD40 PF00400.27 KII71037.1 - 3.7e-06 26.6 0.1 0.0013 18.5 0.0 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat MoaE PF02391.12 KII71038.1 - 4e-24 84.6 0.2 4.6e-24 84.4 0.2 1.0 1 0 0 1 1 1 1 MoaE protein DUF1269 PF06897.7 KII71038.1 - 0.014 15.4 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) EF-hand_10 PF14788.1 KII71040.1 - 0.038 13.6 0.2 0.097 12.3 0.1 1.7 1 0 0 1 1 1 0 EF hand DASH_Dad4 PF08650.5 KII71040.1 - 0.074 12.9 0.5 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 DASH complex subunit Dad4 FG-GAP PF01839.18 KII71044.1 - 6.1e-09 35.3 4.5 0.00036 20.1 2.1 2.4 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.1 KII71044.1 - 1.7e-08 34.6 5.3 1.3e-07 31.8 0.3 2.4 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.3 KII71044.1 - 0.14 11.6 0.0 5.4 6.4 0.0 2.4 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region DUF4113 PF13438.1 KII71045.1 - 2.2e-22 78.4 0.1 3.8e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4113) IMS_C PF11799.3 KII71045.1 - 2.9e-08 33.6 0.0 3.9e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF4143 PF13635.1 KII71046.1 - 0.12 12.5 0.2 0.85 9.8 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4143) DUF1258 PF06869.7 KII71048.1 - 0.044 12.8 0.1 0.045 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) Serpentine_r_xa PF03383.10 KII71048.1 - 0.085 12.6 3.0 0.51 10.0 0.2 2.1 2 0 0 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa Glyco_transf_10 PF00852.14 KII71050.1 - 1.2e-47 162.2 6.8 1.4e-47 161.9 4.7 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) DUF1438 PF07270.6 KII71050.1 - 0.13 12.1 0.1 0.59 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1438) DUF3902 PF13042.1 KII71051.1 - 0.074 12.3 0.5 0.099 11.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3902) DPM2 PF07297.7 KII71051.1 - 0.22 11.8 1.3 0.34 11.2 0.8 1.5 1 1 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) TGF_beta PF00019.15 KII71052.1 - 2.6e-16 59.7 0.8 3.3e-16 59.4 0.5 1.1 1 0 0 1 1 1 1 Transforming growth factor beta like domain Cys_knot PF00007.17 KII71052.1 - 0.054 13.5 1.5 0.35 10.9 1.0 2.1 1 1 0 1 1 1 0 Cystine-knot domain zf-C3HC4_3 PF13920.1 KII71053.1 - 0.076 12.7 8.9 0.15 11.7 6.2 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 KII71053.1 - 0.16 11.5 5.3 0.32 10.5 3.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.1 KII71053.1 - 0.16 11.6 10.6 0.27 11.0 7.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C2H2_6 PF13912.1 KII71053.1 - 0.21 11.5 6.1 2.6 8.0 0.5 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-RING_2 PF13639.1 KII71053.1 - 1.6 8.6 8.8 3.2 7.6 6.1 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 KII71053.1 - 3 7.9 11.6 5.4 7.1 8.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) EMP24_GP25L PF01105.19 KII71054.1 - 1.6e-15 57.2 0.4 2.2e-15 56.8 0.0 1.3 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD DNMT1-RFD PF12047.3 KII71054.1 - 0.099 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Cytosine specific DNA methyltransferase replication foci domain Kunitz_BPTI PF00014.18 KII71055.1 - 1.5e-05 25.1 9.0 2.1e-05 24.5 6.2 1.3 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain GCFC PF07842.7 KII71056.1 - 7.9e-15 54.9 4.8 4.3e-12 45.9 1.8 3.3 2 1 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein LacI PF00356.16 KII71058.1 - 0.00044 19.8 0.0 0.00084 18.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_Tnp_Tc5 PF03221.11 KII71058.1 - 0.00094 18.9 0.9 0.0015 18.2 0.6 1.5 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_3 PF01381.17 KII71058.1 - 0.0022 17.8 0.2 0.0039 16.9 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix CENP-B_N PF04218.8 KII71058.1 - 0.0046 16.3 0.1 0.024 14.0 0.1 2.3 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.1 KII71058.1 - 0.0073 15.8 0.2 0.019 14.4 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII71058.1 - 0.013 15.5 0.5 0.015 15.4 0.3 1.2 1 0 0 1 1 1 0 Winged helix-turn helix HTH_23 PF13384.1 KII71058.1 - 0.027 14.1 0.1 0.027 14.1 0.0 2.0 3 0 0 3 3 3 0 Homeodomain-like domain HTH_IclR PF09339.5 KII71058.1 - 0.029 13.9 0.1 0.064 12.8 0.0 1.6 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_psq PF05225.11 KII71058.1 - 0.034 13.7 0.1 0.068 12.7 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_Crp_2 PF13545.1 KII71058.1 - 0.053 13.3 0.1 0.14 11.9 0.0 1.7 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain NiFeSe_Hases PF00374.14 KII71058.1 - 0.058 12.1 0.1 0.064 12.0 0.1 1.0 1 0 0 1 1 1 0 Nickel-dependent hydrogenase HTH_28 PF13518.1 KII71058.1 - 0.077 13.0 0.2 0.077 13.0 0.1 1.9 2 1 0 2 2 2 0 Helix-turn-helix domain Sigma54_DBD PF04552.8 KII71058.1 - 0.096 12.1 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Sigma-54, DNA binding domain TrmB PF01978.14 KII71058.1 - 0.1 12.3 0.1 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_10 PF04967.7 KII71058.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 HTH DNA binding domain 7tm_1 PF00001.16 KII71059.1 - 2.7e-18 66.0 17.5 3.6e-18 65.6 12.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Glucosamine_iso PF01182.15 KII71061.1 - 1.1e-43 149.2 0.0 1.4e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Spore-coat_CotD PF11122.3 KII71063.1 - 0.04 14.2 0.0 0.051 13.8 0.0 1.4 1 1 0 1 1 1 0 Inner spore coat protein D Peptidase_M16_C PF05193.16 KII71064.1 - 2.9e-14 53.1 0.0 8.9e-14 51.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KII71064.1 - 5.3e-12 45.7 0.0 8.7e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Metallophos PF00149.23 KII71065.1 - 6.8e-42 143.1 0.4 8.9e-42 142.7 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase zf-C2H2_4 PF13894.1 KII71067.1 - 0.031 14.6 1.6 0.11 12.9 1.1 2.1 1 1 0 1 1 1 0 C2H2-type zinc finger Y_Y_Y PF07495.8 KII71067.1 - 0.12 12.0 0.1 0.6 9.9 0.0 2.1 2 0 0 2 2 2 0 Y_Y_Y domain zf-C2H2 PF00096.21 KII71067.1 - 0.92 9.9 2.7 1.4 9.4 0.5 2.4 2 1 0 2 2 2 0 Zinc finger, C2H2 type Glyco_transf_10 PF00852.14 KII71068.1 - 1.3e-32 112.7 1.6 1.6e-32 112.4 1.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) adh_short PF00106.20 KII71069.1 - 4e-15 56.1 0.0 5.6e-15 55.6 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KII71069.1 - 3.3e-09 36.8 0.1 4.2e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KII71069.1 - 1.3e-07 31.4 0.0 1.6e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 KII71069.1 - 0.0017 17.8 0.0 0.0019 17.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 KII71069.1 - 0.0025 16.9 0.1 0.0048 15.9 0.1 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.1 KII71069.1 - 0.011 15.7 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 0 NADH(P)-binding 3HCDH_N PF02737.13 KII71069.1 - 0.018 14.7 0.1 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 KII71069.1 - 0.032 14.3 0.8 0.054 13.5 0.2 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Oxidored_nitro PF00148.14 KII71069.1 - 0.056 12.0 0.2 0.084 11.4 0.1 1.4 1 1 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase RVT_1 PF00078.22 KII71072.1 - 1.1e-09 38.0 0.0 1.6e-09 37.4 0.0 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CBM_10 PF02013.11 KII71072.1 - 0.1 12.8 0.2 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 Cellulose or protein binding domain PSI PF01437.20 KII71076.1 - 0.052 13.7 4.0 0.076 13.1 2.8 1.4 1 1 0 1 1 1 0 Plexin repeat Integrin_beta PF00362.13 KII71077.1 - 4e-06 26.0 0.0 4.1e-06 25.9 0.0 1.0 1 0 0 1 1 1 1 Integrin, beta chain Anp1 PF03452.9 KII71077.1 - 0.017 14.3 0.1 0.018 14.2 0.1 1.1 1 0 0 1 1 1 0 Anp1 VWA PF00092.23 KII71077.1 - 0.019 14.6 0.1 0.025 14.2 0.1 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain UNC-79 PF14776.1 KII71079.1 - 0.046 12.1 2.3 0.062 11.6 1.5 1.3 1 1 0 1 1 1 0 Cation-channel complex subunit UNC-79 DUF2806 PF10987.3 KII71079.1 - 0.083 12.3 0.5 0.11 11.9 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2806) Pkinase PF00069.20 KII71083.1 - 1.4e-09 37.4 1.3 6.8e-08 31.9 0.1 2.2 1 1 1 2 2 2 2 Protein kinase domain EIF_2_alpha PF07541.7 KII71085.1 - 2.6e-26 91.5 0.0 4.5e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit DUF1032 PF06278.6 KII71085.1 - 0.068 11.6 1.0 0.098 11.1 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1032) DNA_pol_phi PF04931.8 KII71085.1 - 8.5 4.0 8.0 11 3.6 5.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi FtsJ PF01728.14 KII71086.1 - 2.4e-48 164.5 0.1 2.7e-48 164.3 0.1 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 KII71086.1 - 0.00078 20.0 0.0 0.031 14.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KII71086.1 - 0.028 14.1 0.0 0.036 13.7 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 KII71086.1 - 0.11 11.6 0.1 0.26 10.3 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family zf-ribbon_3 PF13248.1 KII71092.1 - 0.014 14.5 1.7 0.015 14.5 0.2 1.8 2 0 0 2 2 2 0 zinc-ribbon domain tRNA_synt_2f PF02092.12 KII71092.1 - 0.06 11.8 0.0 0.074 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycyl-tRNA synthetase beta subunit A2L_zn_ribbon PF08792.5 KII71092.1 - 0.061 12.8 0.5 14 5.2 0.0 2.8 2 0 0 2 2 2 0 A2L zinc ribbon domain ADK_lid PF05191.9 KII71092.1 - 0.28 10.8 4.1 0.15 11.7 1.2 1.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid DZR PF12773.2 KII71092.1 - 0.32 10.8 2.0 0.67 9.8 1.4 1.8 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.5 KII71092.1 - 1.2 9.1 4.1 1.4 8.9 1.2 2.4 2 1 0 2 2 2 0 Zinc ribbon domain Maelstrom PF13017.1 KII71094.1 - 0.081 12.3 0.1 0.54 9.7 0.0 1.9 2 0 0 2 2 2 0 piRNA pathway germ-plasm component Ras PF00071.17 KII71095.1 - 6.5e-57 191.4 0.4 7.8e-57 191.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII71095.1 - 2.8e-19 69.7 0.1 4.2e-19 69.1 0.1 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII71095.1 - 1.9e-14 53.2 0.4 2.3e-14 52.9 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KII71095.1 - 1.3e-05 25.0 0.1 2.5e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 KII71095.1 - 0.00014 21.0 0.2 0.00017 20.7 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KII71095.1 - 0.00014 21.3 0.2 0.00056 19.4 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 KII71095.1 - 0.001 19.1 0.1 0.0094 16.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 KII71095.1 - 0.0012 18.1 0.1 0.0021 17.3 0.1 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 KII71095.1 - 0.002 17.6 0.1 0.0036 16.8 0.1 1.6 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 KII71095.1 - 0.0047 16.3 0.1 0.0063 15.9 0.1 1.2 1 0 0 1 1 1 1 AAA-like domain DUF258 PF03193.11 KII71095.1 - 0.0054 15.9 0.3 0.0094 15.1 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function, DUF258 MCM PF00493.18 KII71095.1 - 0.0098 14.7 0.0 0.02 13.6 0.0 1.5 1 0 0 1 1 1 1 MCM2/3/5 family Arch_ATPase PF01637.13 KII71095.1 - 0.013 15.1 0.1 0.024 14.3 0.0 1.3 1 1 0 1 1 1 0 Archaeal ATPase AAA_16 PF13191.1 KII71095.1 - 0.016 15.2 0.2 0.02 14.8 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain YTH PF04146.10 KII71095.1 - 0.016 14.7 0.0 0.023 14.2 0.0 1.3 1 1 0 1 1 1 0 YT521-B-like domain G-alpha PF00503.15 KII71095.1 - 0.017 13.8 1.8 2 7.0 0.1 2.9 1 1 1 2 2 2 0 G-protein alpha subunit AAA_32 PF13654.1 KII71095.1 - 0.018 13.7 0.0 3.4 6.2 0.0 2.5 2 1 1 3 3 3 0 AAA domain ABC_tran PF00005.22 KII71095.1 - 0.019 15.2 0.8 0.03 14.6 0.5 1.8 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.1 KII71095.1 - 0.023 14.3 0.1 0.047 13.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KII71095.1 - 0.023 14.1 0.0 0.057 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.24 KII71095.1 - 0.033 14.3 0.1 0.12 12.5 0.0 2.0 1 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KII71095.1 - 0.074 12.7 0.1 0.17 11.6 0.0 1.6 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 KII71095.1 - 0.098 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain RVP PF00077.15 KII71096.1 - 0.016 15.1 0.1 0.095 12.6 0.0 2.4 1 1 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII71096.1 - 0.16 11.8 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease TFIID_90kDa PF04494.10 KII71097.1 - 0.035 14.1 1.4 0.2 11.6 0.2 2.0 1 1 1 2 2 2 0 WD40 associated region in TFIID subunit Ten_N PF06484.7 KII71097.1 - 0.12 11.4 0.2 0.15 11.1 0.2 1.1 1 0 0 1 1 1 0 Teneurin Intracellular Region RVP PF00077.15 KII71098.1 - 0.018 14.9 0.0 0.048 13.5 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII71098.1 - 0.074 12.8 0.0 0.8 9.5 0.0 2.1 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease TSSC4 PF15264.1 KII71099.1 - 0.014 15.8 0.7 0.094 13.1 0.5 1.9 1 1 0 1 1 1 0 Tumour suppressing sub-chromosomal transferable candidate 4 Thymosin PF01290.15 KII71100.1 - 0.035 13.6 0.2 0.088 12.4 0.1 1.7 1 1 0 1 1 1 0 Thymosin beta-4 family rve PF00665.21 KII71101.1 - 1.8e-16 60.3 0.0 3.6e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71101.1 - 0.0059 16.1 0.1 0.028 13.9 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain DUF1215 PF06744.7 KII71101.1 - 0.033 13.8 0.1 0.47 10.0 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1215) DUF2276 PF10040.4 KII71101.1 - 0.049 13.8 0.0 0.086 13.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2276) DDE_Tnp_IS1595 PF12762.2 KII71104.1 - 1.4e-14 54.1 0.0 2.5e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII71105.1 - 2.7e-06 27.2 0.0 3.6e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain P_proprotein PF01483.15 KII71106.1 - 2e-16 59.5 0.1 3.6e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8 PF00082.17 KII71107.1 - 3.2e-31 108.5 3.2 4e-31 108.2 2.2 1.1 1 0 0 1 1 1 1 Subtilase family Peptidase_S8 PF00082.17 KII71108.1 - 1.8e-38 132.2 0.4 2.8e-38 131.6 0.1 1.4 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 KII71108.1 - 3.3e-16 58.8 0.2 6.3e-16 57.9 0.1 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain DUF2763 PF10961.3 KII71110.1 - 1.2e-06 28.8 0.9 1.4e-06 28.5 0.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2763) Herpes_UL79 PF03049.9 KII71111.1 - 0.066 12.2 0.1 0.098 11.7 0.0 1.1 1 0 0 1 1 1 0 UL79 family Sec7 PF01369.15 KII71113.1 - 0.00024 20.8 0.3 0.00028 20.6 0.2 1.2 1 0 0 1 1 1 1 Sec7 domain UPF0175 PF03683.8 KII71113.1 - 0.0087 15.5 0.1 0.031 13.7 0.0 2.0 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0175) LEF-9 PF05094.7 KII71113.1 - 0.065 11.6 0.5 0.076 11.3 0.3 1.1 1 0 0 1 1 1 0 Late expression factor 9 (LEF-9) ARD PF03079.9 KII71113.1 - 0.14 12.0 0.7 0.2 11.5 0.5 1.2 1 0 0 1 1 1 0 ARD/ARD' family PilN PF05137.8 KII71116.1 - 0.036 13.9 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 Fimbrial assembly protein (PilN) Ctr PF04145.10 KII71117.1 - 0.016 15.2 0.2 0.034 14.2 0.2 1.5 1 0 0 1 1 1 0 Ctr copper transporter family RVT_1 PF00078.22 KII71118.1 - 1.2e-06 28.0 0.8 8.7e-06 25.2 0.1 2.0 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF648 PF04890.8 KII71118.1 - 0.00073 18.7 0.2 0.00086 18.5 0.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF648) DUF1678 PF07913.6 KII71118.1 - 0.11 12.0 0.2 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1678) DDE_3 PF13358.1 KII71119.1 - 0.00091 19.0 0.0 0.0032 17.2 0.0 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease Erf4 PF10256.4 KII71121.1 - 0.022 14.6 1.5 0.26 11.1 0.0 2.4 1 1 2 3 3 3 0 Golgin subfamily A member 7/ERF4 family FliJ PF02050.11 KII71121.1 - 0.034 14.2 2.0 0.07 13.1 1.4 1.6 1 0 0 1 1 1 0 Flagellar FliJ protein ING PF12998.2 KII71121.1 - 0.65 10.3 9.2 0.094 12.9 2.6 2.2 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding RVT_1 PF00078.22 KII71122.1 - 2.2e-09 37.0 0.0 2.9e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_29 PF13551.1 KII71124.1 - 6.2e-09 36.0 0.0 9.1e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII71124.1 - 1e-07 31.3 0.1 8.5e-06 25.2 0.0 2.7 2 1 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.1 KII71124.1 - 1.3e-05 25.8 0.1 4.3e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII71124.1 - 2.7e-05 24.0 0.0 0.00017 21.5 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII71124.1 - 0.0001 22.3 0.4 0.00026 20.9 0.1 1.8 2 0 0 2 2 2 1 Transposase PAX PF00292.13 KII71124.1 - 0.00031 20.4 0.2 0.00043 19.9 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.11 KII71124.1 - 0.00038 20.1 0.0 0.00056 19.5 0.0 1.2 1 0 0 1 1 1 1 Transposase HTH_17 PF12728.2 KII71124.1 - 0.00075 19.7 0.0 0.81 9.9 0.0 2.6 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_psq PF05225.11 KII71124.1 - 0.0027 17.2 0.0 0.25 10.9 0.0 2.3 2 0 0 2 2 2 1 helix-turn-helix, Psq domain TrmB PF01978.14 KII71124.1 - 0.004 16.8 0.0 0.084 12.5 0.0 2.4 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_33 PF13592.1 KII71124.1 - 0.005 16.3 0.1 0.0085 15.6 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_24 PF13412.1 KII71124.1 - 0.0062 15.8 0.2 1.3 8.5 0.0 2.4 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_3 PF01381.17 KII71124.1 - 0.0067 16.2 0.1 0.069 13.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix Sigma70_r4 PF04545.11 KII71124.1 - 0.013 14.8 0.2 0.1 11.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_11 PF08279.7 KII71124.1 - 0.017 14.7 0.1 0.035 13.7 0.1 1.5 1 0 0 1 1 1 0 HTH domain MarR_2 PF12802.2 KII71124.1 - 0.022 14.4 0.0 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 MarR family HTH_37 PF13744.1 KII71124.1 - 0.027 14.2 0.1 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.1 KII71124.1 - 0.037 13.5 0.2 0.33 10.5 0.0 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain Nuc_rec_co-act PF08815.5 KII71124.1 - 0.041 13.4 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 Nuclear receptor coactivator HTH_AsnC-type PF13404.1 KII71124.1 - 0.1 12.1 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Sigma70_r4_2 PF08281.7 KII71124.1 - 0.11 12.0 0.1 4.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 Ank_2 PF12796.2 KII71125.1 - 7.6e-27 93.4 0.5 2e-20 72.9 0.1 1.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KII71125.1 - 1.2e-22 79.8 1.5 4.2e-12 46.2 0.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KII71125.1 - 2.1e-18 65.1 0.1 2.4e-08 33.4 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 KII71125.1 - 4.9e-18 63.4 0.1 9.1e-09 34.7 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KII71125.1 - 3.2e-17 62.1 0.1 1.3e-08 34.7 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) TilS_C PF11734.3 KII71126.1 - 0.037 13.2 0.0 0.055 12.7 0.0 1.3 1 0 0 1 1 1 0 TilS substrate C-terminal domain Kelch_4 PF13418.1 KII71128.1 - 0.068 12.9 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_1 PF01344.20 KII71128.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Kelch motif DDE_3 PF13358.1 KII71129.1 - 4.4e-06 26.5 0.1 6.9e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Vps5 PF09325.5 KII71134.1 - 3.2e-18 65.8 8.5 1.4e-15 57.2 5.9 2.0 1 1 0 1 1 1 1 Vps5 C terminal like BAR_3_WASP_bdg PF10456.4 KII71134.1 - 0.0017 17.6 4.5 0.0035 16.6 2.8 1.8 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PfUIS3 PF11567.3 KII71134.1 - 0.045 13.9 0.5 0.045 13.9 0.3 2.5 2 1 2 4 4 4 0 Plasmodium falciparum UIS3 membrane protein DUF3818 PF12825.2 KII71134.1 - 0.49 9.0 9.2 0.43 9.1 1.8 2.7 1 1 2 3 3 3 0 Domain of unknown function in PX-proteins (DUF3818) rve PF00665.21 KII71135.1 - 3.7e-28 98.0 0.0 7e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII71135.1 - 2.8e-05 23.8 3.4 2.8e-05 23.8 2.3 2.9 3 0 0 3 3 3 2 Zinc knuckle RVP PF00077.15 KII71135.1 - 6.8e-05 22.7 0.1 0.0002 21.2 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease DDE_Tnp_IS240 PF13610.1 KII71135.1 - 0.0021 18.0 0.6 0.0045 16.9 0.0 1.8 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII71135.1 - 0.01 15.3 0.0 0.029 13.9 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain zf-CCHC_4 PF14392.1 KII71135.1 - 0.059 13.0 9.4 0.15 11.7 1.1 2.8 2 0 0 2 2 2 0 Zinc knuckle MutS_V PF00488.16 KII71136.1 - 5.4e-91 304.1 0.0 8.4e-91 303.5 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KII71136.1 - 3.4e-28 98.8 0.3 6.8e-28 97.8 0.2 1.5 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 KII71136.1 - 3.7e-12 46.2 1.0 8.4e-12 45.1 0.7 1.7 1 0 0 1 1 1 1 MutS family domain IV ArfGap PF01412.13 KII71137.1 - 5.2e-32 110.0 1.5 9.2e-32 109.2 0.1 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.24 KII71137.1 - 3.1e-14 53.0 1.0 1.2e-13 51.1 0.7 2.1 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.2 KII71137.1 - 8.3e-11 42.0 0.0 1.6e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KII71137.1 - 3.5e-08 33.7 0.1 9.4e-07 29.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KII71137.1 - 1e-07 31.4 0.1 9.5e-05 22.2 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.25 KII71137.1 - 3.1e-07 29.8 0.0 1.4e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 KII71137.1 - 8.3e-07 29.0 0.0 1.8e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) PH_11 PF15413.1 KII71137.1 - 0.028 14.6 5.4 0.033 14.4 0.8 2.9 2 1 0 2 2 2 0 Pleckstrin homology domain Ribosomal_L16 PF00252.13 KII71138.1 - 2.1e-30 105.1 0.1 2.6e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e TUDOR PF00567.19 KII71139.1 - 0.1 12.4 0.2 0.22 11.3 0.1 1.6 1 1 0 1 1 1 0 Tudor domain Gal-3-0_sulfotr PF06990.6 KII71141.1 - 3.9e-17 62.0 7.0 9.9e-16 57.3 4.9 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Kelch_6 PF13964.1 KII71142.1 - 9.3e-20 69.9 8.9 4.6e-05 23.4 0.0 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 KII71142.1 - 2e-16 59.5 3.2 0.0074 16.0 0.0 5.3 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII71142.1 - 7.1e-15 54.2 7.5 6.6e-05 22.3 0.1 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 KII71142.1 - 5e-12 45.6 7.6 2.4e-05 24.3 0.0 5.5 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII71142.1 - 2.2e-10 40.2 2.1 0.001 18.9 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 KII71142.1 - 2.4e-05 23.9 2.9 0.13 12.1 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 KII71144.1 - 2.5e-18 65.4 3.3 5e-07 29.6 0.3 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII71144.1 - 9e-12 44.5 0.7 0.0029 17.3 0.2 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII71144.1 - 2.9e-11 43.1 0.9 0.0031 17.6 0.0 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII71144.1 - 5.5e-11 41.8 5.1 1e-05 24.9 0.5 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 KII71144.1 - 0.00018 21.3 0.8 0.58 10.1 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII71144.1 - 0.049 13.4 4.8 6.1 6.7 0.4 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 KII71145.1 - 0.00027 20.9 0.2 0.047 13.8 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 KII71145.1 - 0.0035 17.4 0.0 0.092 12.9 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KII71145.1 - 0.0075 16.0 1.6 0.031 14.0 0.1 2.2 1 1 0 2 2 2 1 Galactose oxidase, central domain HTH_23 PF13384.1 KII71146.1 - 0.00013 21.5 0.0 0.00025 20.6 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.1 KII71146.1 - 0.0024 18.6 0.0 0.009 16.7 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.13 KII71146.1 - 0.0089 15.7 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_40 PF14493.1 KII71146.1 - 0.0093 16.1 0.8 0.019 15.1 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.1 KII71146.1 - 0.017 15.1 0.0 0.04 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.1 KII71146.1 - 0.042 13.0 0.0 0.4 9.8 0.0 2.4 3 1 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 HTH_Tnp_Tc5 PF03221.11 KII71149.1 - 5.3e-06 26.1 0.3 8.7e-06 25.4 0.2 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 KII71149.1 - 0.0024 17.2 0.1 0.0055 16.1 0.1 1.6 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain LEF-9 PF05094.7 KII71149.1 - 0.024 13.0 0.1 0.028 12.8 0.0 1.1 1 0 0 1 1 1 0 Late expression factor 9 (LEF-9) HTH_psq PF05225.11 KII71149.1 - 0.028 13.9 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain DUF2315 PF10231.4 KII71149.1 - 0.1 12.4 0.4 0.1 12.4 0.2 1.7 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2315) HTH_23 PF13384.1 KII71149.1 - 0.1 12.2 0.3 0.27 10.9 0.0 1.9 2 1 0 2 2 2 0 Homeodomain-like domain LacI PF00356.16 KII71149.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Kelch_6 PF13964.1 KII71150.1 - 5e-07 29.6 0.5 0.00036 20.5 0.0 2.4 2 1 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII71150.1 - 0.00011 21.6 1.1 0.00062 19.2 0.1 2.4 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.1 KII71150.1 - 0.00033 20.7 0.0 0.00069 19.7 0.0 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KII71150.1 - 0.082 12.6 0.4 0.24 11.2 0.0 2.0 2 1 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.1 KII71151.1 - 6.1e-21 73.6 16.8 5.6e-05 23.1 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII71151.1 - 7.4e-15 54.4 13.5 0.013 15.2 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII71151.1 - 6e-12 44.9 25.4 0.0006 19.2 0.2 6.9 7 0 0 7 7 7 4 Kelch motif Kelch_3 PF13415.1 KII71151.1 - 4.5e-11 42.5 11.4 0.00071 19.6 0.0 6.5 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII71151.1 - 1.6e-09 37.1 15.8 0.084 12.6 0.1 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 KII71151.1 - 6.7e-07 29.1 7.4 0.08 12.9 0.0 5.4 5 0 0 5 5 5 2 Kelch motif DUF4044 PF13253.1 KII71162.1 - 0.0065 15.6 1.9 0.012 14.7 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4044) DDE_3 PF13358.1 KII71163.1 - 3.4e-05 23.6 0.1 0.00036 20.3 0.0 2.1 2 1 0 2 2 2 1 DDE superfamily endonuclease UBN_AB PF14075.1 KII71164.1 - 0.021 14.5 0.1 0.031 13.9 0.1 1.3 1 0 0 1 1 1 0 Ubinuclein conserved middle domain FoP_duplication PF13865.1 KII71164.1 - 0.084 13.3 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 REV PF00424.13 KII71164.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) Kelch_1 PF01344.20 KII71166.1 - 3.1e-18 65.0 22.1 0.00027 20.3 0.3 6.6 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.1 KII71166.1 - 9.7e-18 63.5 22.2 0.0048 17.0 0.4 6.7 7 1 0 7 7 7 5 Kelch motif Kelch_3 PF13415.1 KII71166.1 - 5.2e-15 55.1 15.4 0.00069 19.7 0.1 6.7 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_4 PF13418.1 KII71166.1 - 3.5e-14 52.2 18.3 0.0018 18.0 0.4 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KII71166.1 - 3.1e-09 36.5 16.3 0.00016 21.5 0.0 6.5 7 0 0 7 7 7 3 Kelch motif Kelch_2 PF07646.10 KII71166.1 - 1.3e-08 34.2 12.5 0.00078 19.1 0.1 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.20 KII71168.1 - 1.4e-23 82.1 17.2 1e-06 28.1 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 KII71168.1 - 2.4e-23 81.2 18.5 0.00015 21.7 0.4 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII71168.1 - 5.5e-18 64.4 21.4 0.00016 21.3 0.2 6.7 5 2 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KII71168.1 - 6.7e-18 64.3 13.4 0.00084 19.4 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.10 KII71168.1 - 4.8e-08 32.4 12.6 0.72 9.7 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 KII71168.1 - 2.8e-07 30.3 11.2 0.43 10.5 0.0 5.3 6 0 0 6 6 6 4 Kelch motif Rax2 PF12768.2 KII71168.1 - 9.1e-05 21.7 1.7 0.087 12.0 0.6 3.4 2 1 1 3 3 3 2 Cortical protein marker for cell polarity Asp_protease_2 PF13650.1 KII71170.1 - 6.4e-06 26.5 0.0 9.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII71170.1 - 4.5e-05 23.3 0.0 6.1e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII71170.1 - 0.0035 17.1 0.0 0.011 15.5 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Vps36_ESCRT-II PF11605.3 KII71172.1 - 0.013 15.2 21.3 7.8 6.3 1.0 5.7 1 1 3 4 4 4 0 Vacuolar protein sorting protein 36 Vps36 H_lectin PF09458.5 KII71172.1 - 0.029 14.0 15.0 7.5 6.2 0.3 4.9 2 1 5 7 7 7 0 H-type lectin domain DUF2703 PF10865.3 KII71172.1 - 0.07 13.0 7.3 6.2 6.7 0.1 4.3 2 1 5 7 7 7 0 Domain of unknown function (DUF2703) PLA2_inh PF02988.10 KII71172.1 - 1.7 9.1 9.0 61 4.1 0.6 3.7 1 1 4 5 5 5 0 Phospholipase A2 inhibitor DUF507 PF04368.8 KII71173.1 - 0.066 12.8 0.2 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF507) Jnk-SapK_ap_N PF09744.4 KII71175.1 - 0.14 12.1 2.3 0.24 11.3 1.6 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Kelch_4 PF13418.1 KII71176.1 - 1e-24 86.0 15.8 2.3e-05 24.0 0.2 6.1 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KII71176.1 - 4.9e-22 77.1 16.2 6.6e-08 32.3 0.2 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KII71176.1 - 3.6e-20 71.2 17.5 1.6e-09 37.1 0.1 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 KII71176.1 - 6.5e-15 54.8 10.6 0.00029 20.9 0.1 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KII71176.1 - 1.9e-10 40.4 9.4 0.0014 18.5 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 KII71176.1 - 7.7e-10 38.1 11.8 0.04 13.6 0.1 5.5 6 0 0 6 6 6 4 Kelch motif RPT PF13446.1 KII71176.1 - 0.0099 15.2 0.0 0.15 11.4 0.0 2.5 2 0 0 2 2 2 1 A repeated domain in UCH-protein Rax2 PF12768.2 KII71176.1 - 0.047 12.9 3.9 0.91 8.6 0.0 2.3 1 1 1 2 2 2 0 Cortical protein marker for cell polarity Kelch_6 PF13964.1 KII71177.1 - 2e-05 24.5 0.6 0.15 12.2 0.0 2.9 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII71177.1 - 0.00011 21.6 0.1 0.065 12.7 0.0 2.6 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.1 KII71177.1 - 0.0054 16.4 0.1 0.85 9.4 0.0 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.1 KII71178.1 - 1.1e-25 88.7 14.5 6.5e-06 26.0 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 KII71178.1 - 7.6e-21 73.7 7.8 5.4e-05 23.2 0.1 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.1 KII71178.1 - 3.4e-18 65.1 12.3 5.9e-05 22.7 0.1 5.8 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII71178.1 - 7.5e-17 60.6 19.0 5.7e-08 32.1 0.1 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 KII71178.1 - 7.1e-11 41.8 7.3 0.0011 18.8 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 KII71178.1 - 2.1e-09 36.7 8.1 0.17 11.7 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Rax2 PF12768.2 KII71178.1 - 0.037 13.2 0.3 0.71 9.0 0.0 2.1 1 1 1 2 2 2 0 Cortical protein marker for cell polarity RAG2 PF03089.9 KII71178.1 - 0.04 12.6 0.9 0.4 9.3 0.0 2.6 3 1 1 4 4 4 0 Recombination activating protein 2 Kelch_6 PF13964.1 KII71179.1 - 0.0023 18.0 1.1 1.7 8.9 0.3 2.4 1 1 1 2 2 2 2 Kelch motif Kelch_3 PF13415.1 KII71180.1 - 1.9e-05 24.6 0.9 9.6e-05 22.4 0.1 2.2 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII71180.1 - 5.7e-05 23.1 0.3 0.1 12.8 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII71180.1 - 0.00012 21.7 4.0 0.0008 19.1 0.3 2.2 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.20 KII71180.1 - 0.00024 20.5 0.0 0.52 9.9 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII71180.1 - 0.011 15.4 3.0 0.018 14.8 0.3 2.1 1 1 1 2 2 2 0 Kelch motif Kelch_5 PF13854.1 KII71180.1 - 0.021 14.7 0.8 0.86 9.6 0.0 2.3 2 0 0 2 2 2 0 Kelch motif FLYWCH PF04500.11 KII71181.1 - 7.4e-05 22.5 2.5 0.00019 21.2 1.7 1.7 1 1 0 1 1 1 1 FLYWCH zinc finger domain Spt20 PF12090.3 KII71181.1 - 0.028 13.7 0.1 0.046 13.0 0.1 1.4 1 1 0 1 1 1 0 Spt20 family I-set PF07679.11 KII71181.1 - 0.13 12.1 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Kelch_3 PF13415.1 KII71182.1 - 0.0005 20.1 0.0 0.0016 18.5 0.0 1.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII71182.1 - 0.0024 17.9 0.6 0.019 15.0 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.20 KII71182.1 - 0.65 9.5 2.8 0.51 9.9 0.6 2.0 2 1 0 2 2 2 0 Kelch motif CENP-B_dimeris PF09026.5 KII71184.1 - 0.00025 21.2 1.9 0.00029 21.0 1.3 1.1 1 0 0 1 1 1 1 Centromere protein B dimerisation domain RE_NgoPII PF09521.5 KII71184.1 - 0.083 11.6 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 NgoPII restriction endonuclease AF1Q PF15017.1 KII71184.1 - 0.13 12.1 2.8 0.18 11.6 1.9 1.3 1 0 0 1 1 1 0 Drug resistance and apoptosis regulator PBP1_TM PF14812.1 KII71184.1 - 0.16 12.2 2.8 0.22 11.8 1.9 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleoplasmin PF03066.10 KII71184.1 - 1.1 8.8 4.7 1.4 8.4 3.3 1.2 1 0 0 1 1 1 0 Nucleoplasmin DUF3134 PF11332.3 KII71184.1 - 6.3 7.0 7.7 8.8 6.5 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3134) rve PF00665.21 KII71191.1 - 7.7e-17 61.5 0.0 1.5e-16 60.6 0.0 1.4 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71191.1 - 0.049 13.1 0.0 0.098 12.1 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Neur_chan_memb PF02932.11 KII71192.1 - 0.014 15.3 0.0 0.016 15.0 0.0 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1803 PF08820.5 KII71192.1 - 0.065 12.9 0.1 11 5.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1803) Kelch_6 PF13964.1 KII71194.1 - 5.7e-10 38.9 1.0 0.0048 17.0 0.1 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.1 KII71194.1 - 6.3e-08 32.5 0.4 0.00025 21.0 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KII71194.1 - 2.1e-07 30.6 7.8 0.02 14.6 0.1 4.4 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII71194.1 - 0.001 18.7 3.2 1.3 8.8 0.0 3.7 4 1 0 4 4 4 2 Kelch motif BTB_2 PF02214.17 KII71194.1 - 0.02 15.1 0.1 0.053 13.7 0.0 1.7 2 0 0 2 2 2 0 BTB/POZ domain Kelch_1 PF01344.20 KII71194.1 - 0.074 12.6 12.1 1.1 8.8 0.1 5.0 6 0 0 6 6 6 0 Kelch motif Ribosomal_L37e PF01907.14 KII71195.1 - 0.0036 17.0 1.2 0.0036 17.0 0.8 1.7 2 0 0 2 2 2 1 Ribosomal protein L37e Rhabdo_M1 PF03342.8 KII71195.1 - 0.019 14.1 0.1 0.02 14.0 0.1 1.2 1 0 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) zf-ISL3 PF14690.1 KII71195.1 - 0.16 12.0 1.4 0.31 11.1 1.0 1.5 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 rve PF00665.21 KII71196.1 - 3e-19 69.2 0.0 6.4e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII71196.1 - 0.0047 16.3 0.1 0.0097 15.2 0.1 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Med28 PF11594.3 KII71196.1 - 0.015 15.5 0.0 5.6 7.2 0.1 2.5 1 1 1 2 2 2 0 Mediator complex subunit 28 DUF4502 PF14950.1 KII71197.1 - 0.0074 15.4 0.1 0.011 14.9 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4502) DUF3798 PF12683.2 KII71198.1 - 0.054 12.5 0.0 0.06 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) DUF3623 PF12291.3 KII71203.1 - 0.019 13.9 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3623) DDE_Tnp_IS1595 PF12762.2 KII71204.1 - 0.00022 21.0 0.1 0.00043 20.1 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF3603 PF12227.3 KII71205.1 - 0.014 14.5 0.0 0.017 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3603) RVT_1 PF00078.22 KII71209.1 - 1.1e-07 31.4 0.0 1.7e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Swi3 PF07962.7 KII71209.1 - 0.041 13.5 0.0 0.22 11.2 0.0 2.0 1 1 1 2 2 2 0 Replication Fork Protection Component Swi3 CRISPR_Cas2 PF09827.4 KII71209.1 - 0.048 13.8 0.1 0.07 13.2 0.0 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas2 rve PF00665.21 KII71210.1 - 3.7e-08 33.4 0.1 5.8e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain TRAPPC10 PF12584.3 KII71211.1 - 0.04 13.4 0.2 0.045 13.2 0.1 1.3 1 1 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 Suppressor_APC PF11414.3 KII71212.1 - 6.8e-05 22.5 0.1 0.022 14.5 0.1 2.4 2 0 0 2 2 2 2 Adenomatous polyposis coli tumour suppressor protein BNR PF02012.15 KII71212.1 - 0.00075 18.9 2.7 0.24 11.3 0.1 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat Phospholamban PF04272.9 KII71213.1 - 0.038 13.4 0.0 0.086 12.2 0.0 1.6 1 0 0 1 1 1 0 Phospholamban Ldl_recept_a PF00057.13 KII71213.1 - 0.092 12.6 0.1 0.092 12.6 0.1 3.2 3 1 0 3 3 3 0 Low-density lipoprotein receptor domain class A DDE_3 PF13358.1 KII71215.1 - 2.1e-23 82.6 0.1 1.1e-20 73.9 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF2024 PF09630.5 KII71215.1 - 0.0012 18.4 0.1 0.002 17.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) DDE_1 PF03184.14 KII71215.1 - 0.0016 17.6 0.1 0.0019 17.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII71215.1 - 0.003 17.6 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Colicin_Pyocin PF01320.13 KII71215.1 - 0.0038 17.0 0.1 0.0059 16.4 0.0 1.4 1 0 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein rve PF00665.21 KII71217.1 - 4.1e-14 52.7 0.0 6.4e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71217.1 - 0.00019 20.8 0.0 0.0004 19.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Reg_prop PF07494.6 KII71218.1 - 0.014 15.2 0.2 2.8 8.2 0.0 3.8 3 0 0 3 3 3 0 Two component regulator propeller RSF PF14876.1 KII71221.1 - 0.028 13.2 0.3 0.039 12.7 0.2 1.3 1 1 0 1 1 1 0 Respiratory growth transcriptional regulator UPF0122 PF04297.9 KII71222.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like DDE_1 PF03184.14 KII71226.1 - 3.4e-34 117.8 0.0 3.9e-34 117.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII71226.1 - 0.028 14.1 0.3 0.054 13.2 0.2 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease DUF2110 PF09883.4 KII71227.1 - 0.13 11.8 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) Serpin PF00079.15 KII71229.1 - 2.5e-15 56.4 0.1 3.1e-15 56.2 0.1 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.21 KII71231.1 - 3.9e-13 49.5 0.1 6.9e-13 48.7 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain Mad3_BUB1_I PF08311.7 KII71231.1 - 0.026 14.3 0.0 0.39 10.5 0.0 2.0 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 NOB1_Zn_bind PF08772.6 KII71231.1 - 0.32 10.8 2.7 5.3 6.9 0.0 2.3 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like CLTH PF10607.4 KII71232.1 - 0.053 13.2 0.0 0.21 11.2 0.0 2.1 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DDE_3 PF13358.1 KII71233.1 - 1.7e-16 60.2 0.1 2.1e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII71233.1 - 0.011 14.9 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Serpin PF00079.15 KII71234.1 - 4.4e-05 22.7 0.0 5.4e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_3 PF13358.1 KII71237.1 - 0.02 14.6 0.0 1.7 8.3 0.0 2.2 1 1 1 2 2 2 0 DDE superfamily endonuclease HTH_23 PF13384.1 KII71237.1 - 0.051 13.2 0.1 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain Serpin PF00079.15 KII71239.1 - 4.3e-29 101.8 0.3 4.8e-29 101.6 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF2209 PF09974.4 KII71242.1 - 0.012 15.6 0.2 0.016 15.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) PSRT PF07636.6 KII71243.1 - 0.12 11.8 1.2 0.21 11.1 0.8 1.3 1 0 0 1 1 1 0 PSRT Kelch_6 PF13964.1 KII71245.1 - 8.9e-16 57.3 19.7 0.00054 20.0 0.2 6.0 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII71245.1 - 9.9e-13 47.6 12.6 0.015 15.0 0.0 6.5 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 KII71245.1 - 6.6e-08 32.5 12.6 0.048 13.8 0.1 6.1 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII71245.1 - 1.5e-07 30.8 11.3 0.078 12.5 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 KII71245.1 - 0.00012 21.7 9.6 17 5.3 0.0 6.3 6 0 0 6 6 6 1 Kelch motif Kelch_5 PF13854.1 KII71245.1 - 0.00015 21.6 12.7 0.15 12.0 0.0 5.0 5 0 0 5 5 5 2 Kelch motif RVT_1 PF00078.22 KII71246.1 - 1.2e-09 37.8 0.0 1.6e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII71249.1 - 1.7e-07 31.3 0.0 3.4e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-UBP PF02148.14 KII71251.1 - 0.048 13.7 0.2 0.082 13.0 0.0 1.4 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein rve PF00665.21 KII71252.1 - 1.7e-20 73.3 0.1 3.4e-20 72.3 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71252.1 - 0.0014 18.1 0.0 0.0034 16.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII71252.1 - 0.047 13.4 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 DDE superfamily endonuclease Nepo_coat_N PF03689.10 KII71252.1 - 0.078 12.7 0.1 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain PBP PF01161.15 KII71254.1 - 8e-16 58.1 0.1 9.6e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Phage_Coat_A PF05357.8 KII71258.1 - 0.077 12.5 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Phage Coat Protein A DUF2661 PF10860.3 KII71260.1 - 0.055 13.6 0.2 0.069 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2661) RVT_1 PF00078.22 KII71261.1 - 2.2e-16 59.8 0.1 4.5e-16 58.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L2_C PF03947.13 KII71264.1 - 5.2e-43 145.9 1.3 7.4e-43 145.4 0.9 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 KII71264.1 - 9.8e-14 51.0 0.2 2.4e-13 49.8 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain WD40 PF00400.27 KII71265.1 - 4.5e-19 67.5 1.2 1.3e-07 31.1 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat DUF3312 PF11768.3 KII71265.1 - 0.026 12.7 0.0 0.035 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) eIF2A PF08662.6 KII71265.1 - 0.044 13.4 0.1 0.18 11.5 0.0 1.9 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A ARID PF01388.16 KII71266.1 - 7.8e-17 60.9 0.2 1.3e-16 60.2 0.2 1.3 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Met_asp_mut_E PF06368.6 KII71266.1 - 0.084 11.0 0.0 0.13 10.4 0.0 1.1 1 0 0 1 1 1 0 Methylaspartate mutase E chain (MutE) FerI PF08151.7 KII71267.1 - 0.0058 16.6 0.0 0.18 11.8 0.0 2.1 2 0 0 2 2 2 2 FerI (NUC094) domain EF1G PF00647.14 KII71269.1 - 9.2e-30 102.5 0.1 1.6e-29 101.7 0.1 1.3 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain DUF2201_N PF13203.1 KII71269.1 - 0.07 12.2 6.6 0.091 11.9 4.5 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF2413 PF10310.4 KII71269.1 - 0.78 8.4 9.3 0.94 8.2 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Sporozoite_P67 PF05642.6 KII71269.1 - 1.1 7.0 5.8 1.3 6.8 4.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Peptidase_S49_N PF08496.5 KII71269.1 - 9.4 6.0 9.1 14 5.4 6.3 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RE_AccI PF09545.5 KII71270.1 - 0.071 11.6 0.0 0.096 11.2 0.0 1.2 1 0 0 1 1 1 0 AccI restriction endonuclease ABC_tran_2 PF12848.2 KII71270.1 - 0.19 11.5 3.0 0.72 9.7 0.1 2.5 2 1 0 2 2 2 0 ABC transporter Metallophos PF00149.23 KII71271.1 - 7.7e-07 28.6 5.0 1e-06 28.2 3.5 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KII71271.1 - 0.044 13.6 0.1 0.071 12.9 0.1 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Metallophos_2 PF12850.2 KII71273.1 - 0.0029 17.4 0.3 0.005 16.6 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Proteasome PF00227.21 KII71274.1 - 1.9e-38 131.6 0.5 2.3e-38 131.3 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 KII71274.1 - 0.0028 16.8 2.1 0.014 14.6 1.5 2.1 2 0 0 2 2 2 1 Proteasome beta subunits C terminal DUF1484 PF07363.6 KII71274.1 - 0.018 15.4 0.1 0.028 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1484) HAP2-GCS1 PF10699.4 KII71275.1 - 1.4e-13 50.5 2.8 1.5e-13 50.4 0.3 2.1 1 1 1 2 2 2 1 Male gamete fusion factor DDE_3 PF13358.1 KII71278.1 - 0.00041 20.1 0.1 0.00077 19.2 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII71279.1 - 5.7e-23 81.2 0.0 6.3e-23 81.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII71279.1 - 0.071 12.2 0.0 0.076 12.1 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Ldl_recept_a PF00057.13 KII71282.1 - 3.1e-07 30.1 7.9 3.1e-07 30.1 5.5 3.6 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A KH_dom-like PF14714.1 KII71282.1 - 0.054 13.4 0.1 0.68 9.9 0.0 2.7 2 0 0 2 2 2 0 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal Ldl_recept_a PF00057.13 KII71283.1 - 2e-07 30.7 7.1 2e-07 30.7 4.9 3.2 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII71284.1 - 0.015 14.9 1.3 4.3 7.5 0.0 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat Cas_TM1802 PF09484.5 KII71285.1 - 0.014 13.9 0.1 0.015 13.8 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein TM1802 (cas_TM1802) Defensin_propep PF00879.13 KII71285.1 - 0.059 13.3 0.3 0.17 11.8 0.1 1.8 2 0 0 2 2 2 0 Defensin propeptide SKI PF01202.17 KII71285.1 - 0.099 12.5 0.2 0.13 12.1 0.1 1.1 1 0 0 1 1 1 0 Shikimate kinase Sulfate_transp PF00916.15 KII71290.1 - 6.8e-58 195.8 10.7 1.4e-57 194.8 7.4 1.5 1 0 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KII71290.1 - 2.3e-28 97.6 4.1 1.1e-27 95.5 2.8 2.2 1 0 0 1 1 1 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 KII71290.1 - 4.2e-05 22.9 0.2 8.2e-05 22.0 0.1 1.5 1 0 0 1 1 1 1 STAS domain DUF4118 PF13493.1 KII71290.1 - 0.0035 17.5 4.5 0.0035 17.5 3.1 4.2 2 2 3 5 5 5 1 Domain of unknown function (DUF4118) Mu-like_Com PF10122.4 KII71292.1 - 0.045 12.8 0.0 0.088 11.8 0.0 1.5 1 0 0 1 1 1 0 Mu-like prophage protein Com Sulfate_transp PF00916.15 KII71293.1 - 1.5e-28 99.6 0.6 1.5e-28 99.6 0.4 1.8 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KII71293.1 - 1.8e-24 85.1 2.6 1.8e-24 85.1 1.8 2.0 3 0 0 3 3 3 1 Sulfate transporter N-terminal domain with GLY motif HXXEE PF13787.1 KII71293.1 - 0.61 10.4 5.4 0.3 11.4 1.3 2.3 2 1 0 2 2 2 0 Protein of unknown function with HXXEE motif DUF4050 PF13259.1 KII71294.1 - 0.17 11.7 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) 7tm_1 PF00001.16 KII71295.1 - 1.9e-15 56.7 22.3 2.8e-15 56.1 15.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Phage_connect_1 PF05135.8 KII71297.1 - 0.23 11.6 2.2 8.8 6.5 0.1 2.3 1 1 1 2 2 2 0 Phage gp6-like head-tail connector protein DEK_C PF08766.6 KII71299.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 DEK C terminal domain Gelsolin PF00626.17 KII71310.1 - 0.039 13.6 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 Gelsolin repeat MtrD PF04207.7 KII71311.1 - 0.15 11.4 0.1 0.18 11.1 0.1 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit D Anthrax_toxA PF03497.11 KII71312.1 - 3.8 7.3 9.7 12 5.7 0.4 3.8 1 1 3 4 4 4 0 Anthrax toxin LF subunit RVT_1 PF00078.22 KII71321.1 - 1.6e-05 24.3 0.2 2.8e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GvpK PF05121.7 KII71321.1 - 0.15 11.9 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Gas vesicle protein K rve PF00665.21 KII71322.1 - 1.7e-25 89.4 0.0 3.4e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71322.1 - 0.0022 17.4 0.1 0.01 15.3 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain DUF1231 PF06802.6 KII71323.1 - 0.0092 14.8 0.2 0.015 14.2 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1231) Neurochondrin PF05536.6 KII71323.1 - 0.034 12.4 0.0 0.034 12.4 0.0 1.1 1 0 0 1 1 1 0 Neurochondrin SF3a60_bindingd PF12108.3 KII71323.1 - 0.18 11.3 0.9 2.5 7.6 0.0 2.5 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain Tropomyosin_1 PF12718.2 KII71324.1 - 0.0026 17.6 22.3 0.0026 17.6 15.4 2.4 2 1 0 2 2 2 1 Tropomyosin like DUF2096 PF09869.4 KII71324.1 - 0.022 14.6 8.3 0.091 12.6 0.8 2.6 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) DUF603 PF04645.7 KII71324.1 - 2.4 8.0 17.0 1.6 8.6 5.4 2.9 2 1 0 2 2 2 0 Protein of unknown function, DUF603 Mnd1 PF03962.10 KII71324.1 - 4.3 6.9 28.6 0.68 9.5 10.0 2.4 1 1 1 2 2 2 0 Mnd1 family FlaC_arch PF05377.6 KII71324.1 - 5 7.0 20.0 1.6 8.6 0.9 3.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.5 KII71324.1 - 5.9 7.0 28.3 2 8.5 1.3 3.9 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 KII71324.1 - 5.9 6.7 34.2 0.73 9.6 10.2 3.9 2 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding Pox_A_type_inc PF04508.7 KII71324.1 - 6.8 6.7 19.7 1.4 8.9 1.9 5.5 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat Reo_sigmaC PF04582.7 KII71324.1 - 8.3 5.4 8.5 35 3.4 0.2 2.7 2 1 1 3 3 3 0 Reovirus sigma C capsid protein IncA PF04156.9 KII71324.1 - 9.2 5.8 37.3 1.9 8.0 4.9 3.6 1 1 2 3 3 3 0 IncA protein DUF641 PF04859.7 KII71324.1 - 9.9 5.9 23.4 0.59 9.8 3.1 3.4 2 2 2 4 4 4 0 Plant protein of unknown function (DUF641) NPV_P10 PF05531.7 KII71324.1 - 9.9 6.4 17.5 7.9 6.8 2.1 4.1 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein zf-UBR PF02207.15 KII71328.1 - 1.3e-10 40.8 13.0 3.2e-10 39.5 9.0 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Serpin PF00079.15 KII71330.1 - 8.9e-13 48.1 2.3 1.1e-12 47.8 1.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Pathogen_betaC1 PF09593.5 KII71334.1 - 0.0017 18.0 0.9 0.52 10.0 0.1 2.7 2 0 0 2 2 2 2 Beta-satellite pathogenicity beta C1 protein RRM_1 PF00076.17 KII71336.1 - 1.5e-34 117.4 1.0 1.2e-16 60.0 0.1 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII71336.1 - 4.1e-19 68.3 0.1 1.4e-07 31.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII71336.1 - 1.8e-11 43.6 1.7 2e-06 27.5 0.1 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.6 KII71336.1 - 0.12 12.3 0.2 5.3 7.0 0.1 2.5 2 0 0 2 2 2 0 RNA binding domain DDE_Tnp_IS1595 PF12762.2 KII71338.1 - 6.2e-18 65.0 0.0 7e-18 64.8 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain RRM_1 PF00076.17 KII71340.1 - 4.6e-33 112.6 1.0 7.1e-17 60.7 0.1 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII71340.1 - 8.5e-19 67.3 0.1 1.3e-08 34.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII71340.1 - 7.7e-12 44.8 0.4 1.4e-07 31.2 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MMS19_C PF12460.3 KII71341.1 - 0.00086 18.1 5.4 0.0078 14.9 0.8 2.9 2 1 1 3 3 3 2 RNAPII transcription regulator C-terminal UME PF08064.8 KII71341.1 - 0.032 14.1 1.4 0.52 10.2 0.4 2.6 1 1 1 2 2 2 0 UME (NUC010) domain HEAT_EZ PF13513.1 KII71341.1 - 0.17 12.4 0.7 0.86 10.1 0.0 2.5 3 0 0 3 3 3 0 HEAT-like repeat RVT_1 PF00078.22 KII71342.1 - 0.0086 15.4 0.0 0.021 14.2 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.11 KII71343.1 - 2.7e-33 115.1 20.1 6.8e-30 103.9 12.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KII71343.1 - 4e-07 28.8 20.2 0.00012 20.6 2.0 3.1 2 1 0 3 3 3 3 MFS/sugar transport protein DUF1228 PF06779.9 KII71343.1 - 0.057 13.4 0.1 0.057 13.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1228) UBA PF00627.26 KII71346.1 - 2e-09 36.9 0.1 7.9e-09 35.1 0.1 2.1 1 0 0 1 1 1 1 UBA/TS-N domain Xol-1_N PF09108.5 KII71347.1 - 0.075 12.7 0.0 0.089 12.4 0.0 1.1 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal Tox-MPTase5 PF15641.1 KII71347.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 5 Pkinase_Tyr PF07714.12 KII71348.1 - 3.5e-31 108.2 0.0 4e-31 108.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KII71348.1 - 9.3e-09 34.7 0.0 1.1e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH3_1 PF00018.23 KII71349.1 - 4.6e-10 38.7 0.1 6.8e-10 38.1 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KII71349.1 - 7.5e-08 31.8 0.0 1.1e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KII71349.1 - 1.8e-07 30.5 0.0 2.4e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain zf-RING_2 PF13639.1 KII71350.1 - 3.9e-06 26.5 3.4 3.9e-06 26.5 2.3 2.1 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 KII71350.1 - 0.0028 17.2 1.7 0.018 14.6 1.1 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KII71350.1 - 0.014 15.0 1.9 0.11 12.2 1.3 2.2 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.20 KII71350.1 - 0.081 12.5 2.8 0.14 11.8 0.7 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Auto_anti-p27 PF06677.7 KII71350.1 - 0.15 11.8 0.4 3.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-C3HC4_2 PF13923.1 KII71350.1 - 0.2 11.6 6.5 0.19 11.7 1.7 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 KII71350.1 - 0.26 11.2 4.2 0.49 10.3 1.7 2.4 2 1 0 2 2 2 0 FANCL C-terminal domain zf-rbx1 PF12678.2 KII71350.1 - 0.79 9.8 3.5 2.6 8.1 2.4 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger zf-RING_2 PF13639.1 KII71352.1 - 2.5e-15 55.9 6.5 2.5e-15 55.9 4.5 2.0 2 1 0 2 2 2 1 Ring finger domain zf-RING_3 PF14369.1 KII71352.1 - 4.3e-09 36.2 9.9 2.1e-08 34.0 2.4 3.3 3 0 0 3 3 3 1 zinc-finger zf-C3HC4_3 PF13920.1 KII71352.1 - 1.3e-08 34.3 4.2 1.3e-08 34.3 2.9 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KII71352.1 - 1.6e-07 31.2 8.3 1.6e-07 31.2 5.7 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KII71352.1 - 3.9e-07 30.0 7.0 3.9e-07 30.0 4.9 2.0 2 1 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 KII71352.1 - 1.5e-06 27.8 3.9 1.5e-06 27.8 2.7 2.4 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KII71352.1 - 3.7e-06 26.4 6.2 3.7e-06 26.4 4.3 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 KII71352.1 - 0.0017 18.0 2.8 0.0017 18.0 2.0 2.2 2 1 0 2 2 2 1 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 KII71352.1 - 0.0018 18.0 5.0 0.0018 18.0 3.5 1.9 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_RING PF05883.6 KII71352.1 - 0.14 12.0 1.8 0.24 11.2 0.7 1.7 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.3 KII71352.1 - 0.15 12.0 4.1 0.53 10.2 2.8 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_UBOX PF13445.1 KII71352.1 - 0.25 11.0 3.4 0.36 10.5 0.8 2.3 1 1 1 2 2 2 0 RING-type zinc-finger RINGv PF12906.2 KII71352.1 - 1.5 8.9 6.4 12 6.0 4.4 2.3 1 1 1 2 2 2 0 RING-variant domain PHD PF00628.24 KII71352.1 - 1.7 8.3 11.0 4.2 7.1 2.6 3.1 3 1 0 3 3 3 0 PHD-finger Prok-RING_4 PF14447.1 KII71352.1 - 1.8 8.1 9.4 16 5.0 0.1 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.1 KII71352.1 - 2.3 8.0 7.8 1.9 8.3 0.2 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 1 zf-Nse PF11789.3 KII71352.1 - 3.2 7.3 6.7 7 6.2 4.0 2.0 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DZR PF12773.2 KII71352.1 - 3.6 7.4 8.3 2.4 8.0 0.3 2.6 2 1 0 2 2 2 0 Double zinc ribbon zf-C3HC4_4 PF15227.1 KII71352.1 - 4.8 7.1 12.2 0.99 9.3 3.5 2.8 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING KMP11 PF03037.11 KII71354.1 - 0.018 15.6 0.6 0.057 14.0 0.2 2.0 1 1 1 2 2 2 0 Kinetoplastid membrane protein 11 Homeobox PF00046.24 KII71355.1 - 1.3e-11 43.9 1.2 2e-11 43.3 0.8 1.3 1 0 0 1 1 1 1 Homeobox domain NIR_SIR PF01077.17 KII71355.1 - 0.2 10.9 1.2 0.27 10.6 0.7 1.4 1 1 0 1 1 1 0 Nitrite and sulphite reductase 4Fe-4S domain Vps53_N PF04100.7 KII71356.1 - 1e-62 212.1 13.8 1e-62 212.1 9.6 2.0 2 0 0 2 2 2 1 Vps53-like, N-terminal Peptidase_C1 PF00112.18 KII71357.1 - 1.5e-69 234.2 0.0 2.4e-69 233.5 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII71357.1 - 8.6e-10 38.7 5.3 2e-09 37.6 3.6 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KII71357.1 - 0.00067 18.2 0.7 0.0034 15.9 0.0 2.1 2 1 0 2 2 2 1 Peptidase C1-like family Peptidase_C1 PF00112.18 KII71358.1 - 1.8e-57 194.7 0.0 2.9e-57 194.0 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII71358.1 - 1.9e-11 44.0 2.7 3.2e-11 43.3 1.8 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF694 PF05107.7 KII71358.1 - 0.0043 16.3 0.0 0.0065 15.7 0.0 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF694) Peptidase_C1_2 PF03051.10 KII71358.1 - 0.056 11.9 0.1 0.11 11.0 0.1 1.4 1 0 0 1 1 1 0 Peptidase C1-like family rve PF00665.21 KII71359.1 - 1.1e-06 28.6 0.0 2.2e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain YdjO PF14169.1 KII71361.1 - 0.03 13.7 0.1 0.05 13.0 0.1 1.3 1 0 0 1 1 1 0 Cold-inducible protein YdjO Pox_G5 PF04599.7 KII71362.1 - 0.011 14.4 3.1 0.014 14.1 2.1 1.2 1 0 0 1 1 1 0 Poxvirus G5 protein Piwi PF02171.12 KII71362.1 - 0.014 14.3 2.3 0.015 14.3 1.2 1.3 1 1 0 1 1 1 0 Piwi domain LytR_cpsA_psr PF03816.9 KII71362.1 - 0.029 14.2 0.4 0.03 14.2 0.3 1.2 1 0 0 1 1 1 0 Cell envelope-related transcriptional attenuator domain VP9 PF09625.5 KII71362.1 - 0.12 12.2 0.2 1.8 8.4 0.1 2.3 2 0 0 2 2 2 0 VP9 protein PIF1 PF05970.9 KII71364.1 - 4.9e-05 22.4 0.0 5.5e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Vac14_Fab1_bd PF12755.2 KII71365.1 - 0.01 16.2 3.7 0.28 11.5 0.1 4.2 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region SPAN-X PF07458.7 KII71365.1 - 3.8 7.8 4.6 5.7 7.2 0.2 3.0 3 0 0 3 3 3 0 Sperm protein associated with nucleus, mapped to X chromosome zf-C3HC4_3 PF13920.1 KII71367.1 - 1.6e-05 24.4 12.1 1.6e-05 24.4 8.4 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C2H2 PF00096.21 KII71367.1 - 0.00023 21.2 1.0 0.00023 21.2 0.7 5.7 6 0 0 6 6 6 1 Zinc finger, C2H2 type zf-RING_2 PF13639.1 KII71367.1 - 0.00029 20.5 13.4 0.00029 20.5 9.3 3.8 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.20 KII71367.1 - 0.0019 17.8 17.2 0.0019 17.8 11.9 4.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C2H2_4 PF13894.1 KII71367.1 - 0.017 15.4 0.8 0.017 15.4 0.6 6.3 5 2 1 6 6 6 0 C2H2-type zinc finger Prok-RING_4 PF14447.1 KII71367.1 - 0.26 10.8 12.9 0.18 11.3 5.6 3.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Serpin PF00079.15 KII71368.1 - 4.7e-36 124.6 4.4 5.3e-36 124.5 3.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII71369.1 - 6.2e-47 160.5 3.7 7.4e-47 160.2 2.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF2410 PF10307.4 KII71370.1 - 0.079 12.3 2.7 0.24 10.7 0.3 2.0 2 0 0 2 2 2 0 Hypothetical protein (DUF2410) Serpin PF00079.15 KII71371.1 - 1.6e-21 76.8 0.3 2.1e-21 76.5 0.2 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AbbA_antirepres PF14156.1 KII71371.1 - 0.13 11.8 0.5 20 4.9 0.0 2.9 2 0 0 2 2 2 0 Antirepressor AbbA RNA_replicase_B PF03431.8 KII71373.1 - 0.056 11.6 0.0 0.079 11.1 0.0 1.2 1 0 0 1 1 1 0 RNA replicase, beta-chain Ldl_recept_a PF00057.13 KII71375.1 - 1e-09 38.1 31.8 1.8e-05 24.5 8.0 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF4270 PF14092.1 KII71375.1 - 0.0068 15.0 0.3 0.0088 14.7 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4270) PRKCSH-like PF12999.2 KII71375.1 - 0.037 13.6 19.9 0.052 13.1 13.8 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Ldl_recept_a PF00057.13 KII71376.1 - 1.7e-18 66.1 35.0 2.9e-12 46.2 8.9 2.6 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII71377.1 - 0.62 10.1 8.2 1.3 9.1 0.1 3.2 3 0 0 3 3 3 0 BNR/Asp-box repeat Kelch_4 PF13418.1 KII71380.1 - 7.6e-05 22.3 1.9 0.0075 16.0 0.3 3.0 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII71380.1 - 0.0035 17.4 0.3 0.38 10.9 0.1 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII71380.1 - 0.032 14.4 1.1 0.79 10.0 0.1 2.9 2 1 1 3 3 3 0 Kelch motif Kelch_1 PF01344.20 KII71380.1 - 0.24 10.9 1.7 3.2 7.3 0.1 2.4 2 0 0 2 2 2 0 Kelch motif rve PF00665.21 KII71382.1 - 2.2e-26 92.3 0.1 1.2e-25 89.9 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII71382.1 - 3e-24 85.5 0.0 5.8e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII71382.1 - 1.5e-07 31.2 0.0 3.5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII71382.1 - 0.00015 21.2 0.0 0.0004 19.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.1 KII71382.1 - 0.014 15.9 0.0 0.039 14.4 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease RVT_1 PF00078.22 KII71383.1 - 7.4e-07 28.7 0.0 1.2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ChitinaseA_N PF08329.5 KII71384.1 - 0.013 15.3 0.6 0.53 10.0 0.0 2.4 2 0 0 2 2 2 0 Chitinase A, N-terminal domain RVT_1 PF00078.22 KII71386.1 - 2.2e-07 30.4 0.2 5.4e-07 29.1 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TLP-20 PF06088.6 KII71389.1 - 0.16 11.6 1.7 0.24 11.0 1.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Glu_cys_ligase PF04262.9 KII71401.1 - 0.13 10.7 0.1 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 Glutamate-cysteine ligase zf-Sec23_Sec24 PF04810.10 KII71403.1 - 0.01 15.4 0.4 0.019 14.4 0.3 1.5 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger zf-A20 PF01754.11 KII71403.1 - 0.18 11.4 0.2 0.18 11.4 0.2 1.8 2 0 0 2 2 2 0 A20-like zinc finger Rad17 PF03215.10 KII71405.1 - 1.7e-17 63.3 12.5 2.8e-15 56.0 8.2 2.5 1 1 1 2 2 2 1 Rad17 cell cycle checkpoint protein MULE PF10551.4 KII71406.1 - 0.077 13.1 0.0 0.18 11.9 0.0 1.6 2 0 0 2 2 2 0 MULE transposase domain Utp14 PF04615.8 KII71407.1 - 6.5e-51 173.3 41.8 2e-31 108.9 19.7 2.2 2 0 0 2 2 2 2 Utp14 protein DUF4075 PF13294.1 KII71407.1 - 0.022 14.8 0.3 0.022 14.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4075) CTP_transf_2 PF01467.21 KII71408.1 - 1e-17 64.5 0.0 3.8e-12 46.5 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase Dimer_Tnp_hAT PF05699.9 KII71409.1 - 0.00054 19.5 0.3 0.00095 18.7 0.2 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region CM2 PF03021.9 KII71409.1 - 0.07 12.6 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 Influenza C virus M2 protein HhH-GPD PF00730.20 KII71412.1 - 5.9e-18 65.1 0.0 7.7e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 KII71412.1 - 2.7e-09 36.2 0.0 7.4e-09 34.8 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_8 PF14716.1 KII71412.1 - 0.088 13.0 0.1 0.33 11.1 0.0 1.8 1 1 0 1 1 1 0 Helix-hairpin-helix domain HHH_3 PF12836.2 KII71412.1 - 0.097 12.6 0.0 0.3 11.0 0.0 1.7 1 1 1 2 2 2 0 Helix-hairpin-helix motif HHH_5 PF14520.1 KII71412.1 - 0.098 12.8 0.0 0.18 11.9 0.0 1.6 1 1 0 1 1 1 0 Helix-hairpin-helix domain HHH_2 PF12826.2 KII71412.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif ArgK PF03308.11 KII71413.1 - 1.8e-74 249.8 0.1 2.4e-74 249.5 0.1 1.1 1 0 0 1 1 1 1 ArgK protein cobW PF02492.14 KII71413.1 - 1e-06 28.3 0.7 4e-06 26.3 0.5 1.9 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.18 KII71413.1 - 0.00011 22.1 0.3 0.00047 20.1 0.1 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase KAP_NTPase PF07693.9 KII71413.1 - 0.00026 20.1 0.4 0.00082 18.4 0.0 1.8 2 0 0 2 2 2 1 KAP family P-loop domain AAA_17 PF13207.1 KII71413.1 - 0.0017 19.1 0.1 0.0043 17.8 0.1 1.7 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 KII71413.1 - 0.004 16.6 2.4 0.012 15.0 0.4 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_10 PF12846.2 KII71413.1 - 0.004 16.6 0.1 0.009 15.4 0.1 1.6 1 0 0 1 1 1 1 AAA-like domain AAA_18 PF13238.1 KII71413.1 - 0.0054 17.0 0.6 0.014 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KII71413.1 - 0.011 14.9 1.8 0.012 14.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 KII71413.1 - 0.012 15.6 0.1 0.026 14.5 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 KII71413.1 - 0.033 14.3 0.6 0.53 10.4 0.0 2.7 2 1 0 2 2 2 0 RNA helicase AAA PF00004.24 KII71413.1 - 0.033 14.3 0.3 0.085 13.0 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.12 KII71413.1 - 0.11 12.2 5.6 0.34 10.7 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function DUF87 AAA_19 PF13245.1 KII71413.1 - 0.13 12.0 0.1 2.6 7.8 0.0 2.4 2 0 0 2 2 2 0 Part of AAA domain ABC_tran PF00005.22 KII71413.1 - 0.14 12.4 0.4 0.14 12.4 0.3 2.2 2 1 1 3 3 3 0 ABC transporter Ribosomal_60s PF00428.14 KII71415.1 - 6.4e-14 52.1 0.9 7.6e-14 51.8 0.6 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein zf-CCCH_2 PF14608.1 KII71416.1 - 3e-06 27.0 52.1 2e-05 24.3 3.6 4.4 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type DUF3733 PF12534.3 KII71417.1 - 7.1e-07 28.4 0.1 7.1e-07 28.4 0.1 3.4 4 0 0 4 4 4 1 Leucine-rich repeat containing protein 8 CytadhesinP1 PF12378.3 KII71418.1 - 0.048 13.6 0.1 0.1 12.5 0.0 1.6 1 1 1 2 2 2 0 Trypsin-sensitive surface-exposed protein DUF2325 PF10087.4 KII71418.1 - 0.09 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) ParcG PF10274.4 KII71419.1 - 0.0013 18.7 0.0 0.0014 18.6 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein LRR_6 PF13516.1 KII71420.1 - 0.011 15.7 0.5 1.7 8.9 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich repeat LRR_4 PF12799.2 KII71420.1 - 0.18 11.4 4.1 0.75 9.4 0.3 3.3 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KII71420.1 - 0.69 9.7 5.5 4.9 6.9 0.7 3.1 2 1 1 3 3 3 0 Leucine rich repeat LRR_1 PF00560.28 KII71420.1 - 1.2 9.4 6.9 16 6.0 0.5 4.5 4 2 0 4 4 4 0 Leucine Rich Repeat MULE PF10551.4 KII71421.1 - 0.00061 19.9 0.1 0.0012 18.9 0.1 1.6 1 0 0 1 1 1 1 MULE transposase domain Serpin PF00079.15 KII71422.1 - 5.3e-52 177.1 9.5 6e-52 176.9 6.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_3 PF13358.1 KII71423.1 - 2.9e-05 23.8 0.0 5.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII71424.1 - 1.3e-16 60.6 0.0 3.1e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease R3H-assoc PF13902.1 KII71425.1 - 0.028 14.3 0.6 0.056 13.4 0.4 1.6 1 1 0 1 1 1 0 R3H-associated N-terminal domain CDC37_C PF08564.5 KII71428.1 - 0.0027 17.5 1.0 0.0038 17.0 0.7 1.3 1 0 0 1 1 1 1 Cdc37 C terminal domain DUF948 PF06103.6 KII71428.1 - 0.031 14.1 1.8 0.031 14.1 1.3 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.16 KII71428.1 - 0.038 13.5 0.1 0.052 13.0 0.1 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.7 KII71428.1 - 0.058 13.1 3.7 0.043 13.5 1.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Neur_chan_memb PF02932.11 KII71428.1 - 0.064 13.1 0.3 0.08 12.8 0.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Apolipoprotein PF01442.13 KII71428.1 - 0.074 12.5 1.8 0.16 11.4 1.3 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.7 KII71428.1 - 0.1 12.4 5.9 0.41 10.4 4.3 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC1 PF03109.11 KII71428.1 - 0.11 12.4 0.4 0.38 10.7 0.1 2.0 2 0 0 2 2 2 0 ABC1 family HI0933_like PF03486.9 KII71428.1 - 0.12 10.8 3.8 0.079 11.4 1.6 1.5 1 1 1 2 2 2 0 HI0933-like protein CRISPR_Cas2 PF09827.4 KII71428.1 - 0.14 12.2 2.3 0.84 9.8 0.1 2.6 1 1 0 2 2 2 0 CRISPR associated protein Cas2 DUF2570 PF10828.3 KII71428.1 - 0.22 11.1 3.8 0.15 11.6 1.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) Peptidase_S28 PF05577.7 KII71428.1 - 0.28 9.6 1.6 0.3 9.6 1.1 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Peptidase_C6 PF00851.13 KII71428.1 - 0.33 9.5 6.9 0.38 9.3 4.7 1.0 1 0 0 1 1 1 0 Helper component proteinase Phage_lysis PF03245.8 KII71428.1 - 0.36 10.8 2.2 3.6 7.5 0.2 2.5 1 1 2 3 3 3 0 Bacteriophage Rz lysis protein Rho_Binding PF08912.6 KII71428.1 - 2 8.8 8.9 1 9.7 2.2 2.8 1 1 2 3 3 3 0 Rho Binding Enkurin PF13864.1 KII71428.1 - 2.2 8.5 8.9 1.6 9.0 0.4 3.2 1 1 2 3 3 3 0 Calmodulin-binding Vps51 PF08700.6 KII71428.1 - 2.3 8.1 10.1 1.5 8.6 3.0 2.7 1 1 1 2 2 2 0 Vps51/Vps67 Fib_alpha PF08702.5 KII71428.1 - 4.4 7.4 14.2 2.7 8.1 7.7 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family YlbD_coat PF14071.1 KII71428.1 - 5.1 7.1 7.7 0.88 9.6 2.0 2.0 1 1 1 2 2 2 0 Putative coat protein DUF1132 PF06575.7 KII71429.1 - 0.018 15.3 0.5 0.13 12.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1132) GlnD_UR_UTase PF08335.6 KII71429.1 - 0.042 13.6 0.1 0.1 12.4 0.1 1.5 1 1 0 1 1 1 0 GlnD PII-uridylyltransferase HTH_32 PF13565.1 KII71431.1 - 1.5e-06 28.9 0.1 4.3e-06 27.4 0.2 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.1 KII71431.1 - 7.1e-06 25.5 0.0 0.00037 20.0 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII71431.1 - 1e-05 25.2 0.3 1.3e-05 24.8 0.2 1.2 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.1 KII71431.1 - 2.3e-05 24.5 0.0 3.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII71431.1 - 2.9e-05 23.9 0.0 7.7e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII71431.1 - 9.8e-05 22.3 1.0 0.0002 21.3 0.3 1.7 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.1 KII71431.1 - 0.00013 21.4 0.0 0.00027 20.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 KII71431.1 - 0.00045 19.9 0.0 0.00062 19.4 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_24 PF13412.1 KII71431.1 - 0.0013 18.0 0.2 1.7 8.1 0.0 3.1 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding DUF3423 PF11903.3 KII71431.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3423) Arg_repressor PF01316.16 KII71431.1 - 0.095 12.2 1.3 0.17 11.4 0.9 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Rrf2 PF02082.15 KII71431.1 - 0.11 12.5 0.1 0.36 10.9 0.0 1.9 2 0 0 2 2 2 0 Transcriptional regulator Sigma54_AID PF00309.15 KII71431.1 - 0.47 9.9 2.3 1 8.8 0.1 2.1 1 1 1 2 2 2 0 Sigma-54 factor, Activator interacting domain (AID) HSP20 PF00011.16 KII71432.1 - 3.5e-25 87.8 9.3 1.9e-15 56.5 2.2 2.0 1 1 1 2 2 2 2 Hsp20/alpha crystallin family DUF3794 PF12673.2 KII71432.1 - 0.0035 17.4 4.0 0.021 14.9 0.2 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF3794) GRAS PF03514.9 KII71434.1 - 0.094 11.4 0.6 0.11 11.2 0.3 1.3 1 1 1 2 2 2 0 GRAS domain family DDE_3 PF13358.1 KII71436.1 - 6.9e-29 100.4 0.0 1.3e-28 99.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.1 KII71436.1 - 3.1e-08 34.2 0.0 4.9e-07 30.4 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII71436.1 - 1.4e-06 28.4 0.0 2.2e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII71436.1 - 3.8e-06 26.3 0.0 6.7e-05 22.3 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII71436.1 - 0.00023 21.0 0.2 0.0015 18.5 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII71436.1 - 0.0017 18.0 0.1 0.0029 17.2 0.1 1.3 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc3_2 PF01498.13 KII71436.1 - 0.0094 15.9 0.2 0.12 12.4 0.0 2.5 2 0 0 2 2 2 1 Transposase DDE_1 PF03184.14 KII71436.1 - 0.0095 15.0 0.2 0.23 10.5 0.0 2.5 2 1 1 3 3 3 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 KII71436.1 - 0.01 14.5 0.0 0.67 8.6 0.0 2.3 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain HTH_33 PF13592.1 KII71436.1 - 0.014 14.8 0.0 0.036 13.5 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix Toxin_64 PF15542.1 KII71436.1 - 0.015 15.8 6.4 6.2 7.4 3.1 3.1 2 1 0 2 2 2 0 Putative toxin 64 TrmB PF01978.14 KII71436.1 - 0.023 14.3 0.1 0.052 13.2 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Rep_3 PF01051.16 KII71436.1 - 0.039 13.5 0.1 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 Initiator Replication protein HTH_40 PF14493.1 KII71436.1 - 0.1 12.8 0.2 0.39 10.9 0.1 2.1 1 1 1 2 2 2 0 Helix-turn-helix domain rve PF00665.21 KII71437.1 - 1.1e-29 102.9 0.0 3.4e-29 101.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII71437.1 - 1.1e-25 90.2 0.1 2.5e-25 89.1 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII71437.1 - 9.1e-06 25.5 0.1 2.4e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII71437.1 - 1.2e-05 24.8 0.0 4.2e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.18 KII71437.1 - 1.9e-05 24.3 9.7 0.004 16.9 1.4 2.8 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.1 KII71437.1 - 0.00029 20.4 7.0 0.12 12.0 1.9 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII71437.1 - 0.001 19.5 0.0 0.0026 18.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII71437.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.1 KII71437.1 - 0.002 17.6 0.0 0.0067 15.9 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.6 KII71437.1 - 0.0025 17.7 0.4 0.006 16.5 0.3 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII71437.1 - 0.083 12.6 11.8 0.016 14.9 1.1 2.8 1 1 1 2 2 2 0 Zinc knuckle DDE_3 PF13358.1 KII71438.1 - 1.1e-06 28.4 0.2 3.2e-06 26.9 0.1 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease YEATS PF03366.11 KII71438.1 - 0.012 15.3 0.1 0.015 14.9 0.1 1.2 1 0 0 1 1 1 0 YEATS family Orn_Arg_deC_N PF02784.11 KII71439.1 - 5.6e-68 228.8 0.0 7.1e-68 228.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 KII71439.1 - 6.5e-25 87.0 0.2 1.3e-24 86.1 0.1 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Gemini_AL2 PF01440.11 KII71439.1 - 0.18 11.8 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Geminivirus AL2 protein GSu_C4xC__C2xCH PF09698.5 KII71441.1 - 0.067 13.3 0.1 0.87 9.8 0.0 2.2 2 0 0 2 2 2 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) XRN_N PF03159.13 KII71442.1 - 5.9e-19 68.3 0.7 2.1e-14 53.4 0.0 2.0 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus Dna2 PF08696.6 KII71443.1 - 0.00088 18.6 0.1 0.0012 18.2 0.1 1.3 1 1 0 1 1 1 1 DNA replication factor Dna2 Rcd1 PF04078.8 KII71443.1 - 0.04 12.7 0.1 0.048 12.4 0.1 1.2 1 0 0 1 1 1 0 Cell differentiation family, Rcd1-like AAA_11 PF13086.1 KII71444.1 - 1.8e-22 80.0 0.1 2.1e-22 79.8 0.1 1.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KII71444.1 - 1.2e-08 34.5 0.0 1.3e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KII71444.1 - 1.9e-08 34.1 0.0 2.4e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 KII71444.1 - 4e-06 26.4 0.0 4.5e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain UvrD-helicase PF00580.16 KII71444.1 - 0.00054 19.3 0.0 0.00073 18.9 0.0 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA PF00004.24 KII71444.1 - 0.00079 19.6 0.2 0.00099 19.3 0.1 1.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 KII71444.1 - 0.00094 18.1 0.1 0.0018 17.2 0.0 1.5 1 1 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.10 KII71444.1 - 0.0012 18.7 0.1 0.0014 18.5 0.1 1.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.16 KII71444.1 - 0.0034 16.5 0.0 0.0044 16.1 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 KII71444.1 - 0.0041 16.6 0.0 0.0061 16.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Helicase_RecD PF05127.9 KII71444.1 - 0.0053 16.4 0.0 0.0056 16.3 0.0 1.1 1 0 0 1 1 1 1 Helicase AAA_23 PF13476.1 KII71444.1 - 0.0061 16.8 1.0 0.0098 16.2 0.7 1.4 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 KII71444.1 - 0.012 15.2 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.18 KII71444.1 - 0.017 14.5 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RuvB_N PF05496.7 KII71444.1 - 0.017 14.1 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 KII71444.1 - 0.019 14.9 0.0 0.02 14.9 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.1 KII71444.1 - 0.019 14.8 0.1 0.025 14.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain DEAD PF00270.24 KII71444.1 - 0.021 14.3 0.1 0.023 14.1 0.1 1.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.1 KII71444.1 - 0.023 14.8 0.1 0.036 14.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain PEPCK_ATP PF01293.15 KII71444.1 - 0.035 12.6 0.0 0.035 12.6 0.0 1.2 1 1 0 1 1 1 0 Phosphoenolpyruvate carboxykinase AAA_5 PF07728.9 KII71444.1 - 0.038 13.6 0.1 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 KII71444.1 - 0.047 13.9 0.1 0.058 13.6 0.1 1.3 1 1 0 1 1 1 0 ABC transporter DUF3847 PF12958.2 KII71444.1 - 0.051 13.3 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) DUF815 PF05673.8 KII71444.1 - 0.054 12.4 0.0 0.071 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ArsA_ATPase PF02374.10 KII71444.1 - 0.063 12.3 0.2 0.11 11.4 0.1 1.4 1 1 0 1 1 1 0 Anion-transporting ATPase SMC_N PF02463.14 KII71444.1 - 0.082 12.1 0.0 0.12 11.6 0.0 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 KII71444.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4112 PF13430.1 KII71444.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4112) MMR_HSR1 PF01926.18 KII71444.1 - 0.17 11.8 0.6 0.21 11.5 0.4 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_12 PF13087.1 KII71445.1 - 2e-42 144.8 0.0 2.5e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KII71445.1 - 8.7e-09 35.2 0.0 1.5e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KII71445.1 - 0.00031 20.3 0.0 0.31 10.5 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase SH3_9 PF14604.1 KII71446.1 - 4.1e-13 48.6 0.0 4.1e-09 35.8 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 KII71446.1 - 2.1e-11 43.0 0.2 3.2e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.12 KII71446.1 - 2e-08 33.5 0.1 5.7e-06 25.7 0.0 2.4 2 1 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.6 KII71446.1 - 0.00041 20.4 0.4 0.74 10.0 0.0 2.2 2 0 0 2 2 2 2 Bacterial SH3 domain SH3_6 PF12913.2 KII71446.1 - 0.019 14.2 0.0 0.041 13.1 0.0 1.6 1 0 0 1 1 1 0 SH3 domain of the SH3b1 type Ribosomal_L40e PF01020.12 KII71449.1 - 1.1e-24 85.7 11.1 1.8e-24 85.0 7.7 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.3 KII71449.1 - 7.4e-09 35.1 0.0 1.1e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KII71449.1 - 1.5e-08 33.8 0.0 2.2e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family TUG-UBL1 PF11470.3 KII71449.1 - 0.019 14.9 0.0 0.052 13.4 0.0 1.7 1 1 0 1 1 1 0 GLUT4 regulating protein TUG DUF258 PF03193.11 KII71449.1 - 0.084 12.0 0.1 0.12 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF258 zf-DHHC PF01529.15 KII71449.1 - 0.56 9.5 4.9 0.84 9.0 3.4 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase Fer2_3 PF13085.1 KII71449.1 - 1.3 8.8 5.6 7.5 6.4 0.1 2.2 1 1 1 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Abhydrolase_2 PF02230.11 KII71450.1 - 1.6e-06 27.7 0.3 1.8e-06 27.5 0.2 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase LIP PF03583.9 KII71450.1 - 0.012 14.8 0.1 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 Secretory lipase DLH PF01738.13 KII71450.1 - 0.016 14.5 0.2 0.019 14.2 0.1 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S9 PF00326.16 KII71450.1 - 0.093 11.9 0.2 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase family HTH_23 PF13384.1 KII71451.1 - 2.7e-06 26.8 0.1 1.4e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII71451.1 - 1e-05 25.6 0.0 1.7e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII71451.1 - 1.7e-05 24.6 0.1 7.7e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.13 KII71451.1 - 0.00027 20.6 0.0 0.00053 19.7 0.0 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_38 PF13936.1 KII71451.1 - 0.00093 18.7 0.0 0.002 17.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII71451.1 - 0.003 17.5 0.0 0.12 12.4 0.0 2.4 2 0 0 2 2 2 1 Transposase HTH_3 PF01381.17 KII71451.1 - 0.011 15.5 0.0 0.053 13.3 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix HTH_37 PF13744.1 KII71451.1 - 0.018 14.8 0.0 0.043 13.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_psq PF05225.11 KII71451.1 - 0.032 13.7 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Piwi PF02171.12 KII71452.1 - 8.7e-56 189.1 0.1 1e-55 188.8 0.1 1.0 1 0 0 1 1 1 1 Piwi domain HTH_29 PF13551.1 KII71455.1 - 6.7e-06 26.2 0.1 8.1e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII71455.1 - 0.00059 20.5 0.0 0.00099 19.8 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_23 PF13384.1 KII71455.1 - 0.0006 19.3 0.8 0.084 12.5 0.0 2.6 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.1 KII71455.1 - 0.0011 18.8 1.6 0.0036 17.2 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.13 KII71455.1 - 0.0016 18.1 0.3 0.0019 17.9 0.2 1.1 1 0 0 1 1 1 1 'Paired box' domain TrmB PF01978.14 KII71455.1 - 0.0048 16.5 0.0 0.0073 15.9 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Tnp_IS630 PF01710.11 KII71455.1 - 0.01 15.5 0.3 0.16 11.6 0.0 2.0 1 1 1 2 2 2 1 Transposase HTH_37 PF13744.1 KII71455.1 - 0.016 14.9 0.1 0.038 13.7 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain DUF3634 PF12321.3 KII71455.1 - 0.019 14.9 0.1 0.023 14.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3634) DUF359 PF04019.7 KII71455.1 - 0.035 13.4 0.5 0.065 12.6 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF359) CENP-B_N PF04218.8 KII71455.1 - 0.054 12.9 1.2 0.072 12.5 0.1 1.8 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain DUF977 PF06163.6 KII71455.1 - 0.088 12.5 0.8 2 8.1 0.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF977) HTH_3 PF01381.17 KII71455.1 - 0.11 12.4 0.0 0.44 10.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix Ig_J_chain PF15097.1 KII71456.1 - 0.023 14.2 0.2 0.032 13.8 0.2 1.4 1 0 0 1 1 1 0 Immunoglobulin J chain DUF4441 PF14536.1 KII71457.1 - 1.6 8.7 12.5 0.38 10.7 2.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4441) Lysis_S PF04971.7 KII71459.1 - 0.0047 16.5 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Lysis protein S M_domain PF12938.2 KII71460.1 - 0.037 13.8 0.0 0.044 13.5 0.0 1.1 1 0 0 1 1 1 0 M domain of GW182 DDE_3 PF13358.1 KII71461.1 - 0.0033 17.1 0.1 0.004 16.9 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease DltD_C PF04914.7 KII71461.1 - 0.055 13.3 0.8 0.074 12.9 0.5 1.2 1 0 0 1 1 1 0 DltD C-terminal region PIN_4 PF13638.1 KII71462.1 - 0.18 11.9 2.1 0.35 10.9 1.5 1.5 1 0 0 1 1 1 0 PIN domain AKAP95 PF04988.7 KII71464.1 - 0.0062 16.3 0.6 0.0062 16.3 0.4 2.1 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) zf-H2C2_5 PF13909.1 KII71464.1 - 0.0086 16.2 0.4 0.0086 16.2 0.3 4.2 6 0 0 6 6 6 2 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.1 KII71464.1 - 0.054 13.8 14.5 0.12 12.7 0.7 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger EndIII_4Fe-2S PF10576.4 KII71465.1 - 0.11 12.6 4.2 0.23 11.7 2.9 1.5 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III DUF2895 PF11444.3 KII71468.1 - 0.096 11.8 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) zf-C2H2_4 PF13894.1 KII71470.1 - 7.4e-06 25.9 1.6 1.9 8.9 0.0 3.7 3 1 1 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 KII71470.1 - 0.0015 18.7 6.0 0.25 11.7 0.0 3.7 3 2 0 3 3 3 1 Zinc finger, C2H2 type zf-Di19 PF05605.7 KII71470.1 - 0.055 13.5 0.9 0.093 12.8 0.1 1.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.1 KII71470.1 - 0.32 11.3 0.0 0.32 11.3 0.0 2.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-LYAR PF08790.6 KII71470.1 - 0.35 10.6 2.1 29 4.4 0.0 3.5 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-H2C2_2 PF13465.1 KII71470.1 - 1.8 9.0 8.6 20 5.6 0.1 4.0 4 0 0 4 4 4 0 Zinc-finger double domain Ldl_recept_a PF00057.13 KII71471.1 - 1.4e-42 143.2 125.4 1.7e-10 40.5 8.8 7.6 7 0 0 7 7 7 7 Low-density lipoprotein receptor domain class A Cytochrom_B559a PF00284.15 KII71471.1 - 0.1 12.1 0.1 0.28 10.7 0.1 1.8 1 0 0 1 1 1 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit BNR PF02012.15 KII71471.1 - 0.15 11.9 1.2 0.95 9.5 0.2 2.7 2 0 0 2 2 2 0 BNR/Asp-box repeat DDE_Tnp_Tn3 PF01526.12 KII71474.1 - 0.061 11.9 0.0 0.078 11.5 0.0 1.1 1 0 0 1 1 1 0 Tn3 transposase DDE domain zf-UBR PF02207.15 KII71475.1 - 2.8e-11 42.9 13.1 6.7e-11 41.7 9.1 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Hemocyanin_M PF00372.14 KII71476.1 - 0.11 11.7 0.1 0.13 11.4 0.0 1.0 1 0 0 1 1 1 0 Hemocyanin, copper containing domain DUF2338 PF10100.4 KII71477.1 - 0.11 10.9 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2338) DUF1647 PF07801.6 KII71478.1 - 0.045 13.2 0.5 0.067 12.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) DUF367 PF04034.8 KII71478.1 - 0.083 12.4 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF367) PSII_BNR PF14870.1 KII71478.1 - 0.14 11.1 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 Pox_E8 PF03394.8 KII71479.1 - 0.064 12.6 0.0 0.089 12.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus E8 protein RVP PF00077.15 KII71480.1 - 2.1e-05 24.3 0.0 2.4e-05 24.1 0.0 1.0 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII71480.1 - 0.028 14.8 0.0 0.039 14.4 0.0 1.2 1 0 0 1 1 1 0 Aspartyl protease DUF3907 PF13047.1 KII71481.1 - 0.0065 16.1 0.1 0.0067 16.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3907) Gp49 PF05973.9 KII71481.1 - 0.072 13.1 0.0 0.12 12.3 0.0 1.4 2 0 0 2 2 2 0 Phage derived protein Gp49-like (DUF891) CtIP_N PF10482.4 KII71481.1 - 0.072 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain SNAP PF14938.1 KII71482.1 - 0.00086 18.5 2.2 0.001 18.2 1.5 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.1 KII71482.1 - 0.0031 17.1 4.5 1.6 8.6 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KII71482.1 - 0.0066 16.0 3.6 5.6 6.7 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII71482.1 - 0.055 13.4 1.3 23 5.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII71482.1 - 0.065 12.8 2.4 15 5.2 0.0 3.1 2 1 0 2 2 2 0 TPR repeat DDE_3 PF13358.1 KII71483.1 - 9.6e-08 31.8 0.0 1.4e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DEAD PF00270.24 KII71484.1 - 4.8e-43 146.5 0.0 1.1e-42 145.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII71484.1 - 1.8e-24 85.4 0.0 4.1e-24 84.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII71484.1 - 5.2e-06 26.4 0.0 1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Dehyd-heme_bind PF09098.5 KII71484.1 - 0.09 12.2 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding Cofilin_ADF PF00241.15 KII71485.1 - 3.8e-19 68.8 0.4 4.5e-19 68.5 0.2 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein YolD PF08863.5 KII71485.1 - 0.016 15.0 0.3 0.32 10.8 0.2 2.1 2 0 0 2 2 2 0 YolD-like protein DUF1789 PF08748.6 KII71485.1 - 0.059 13.4 0.1 0.11 12.6 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1789) PAC2 PF09754.4 KII71486.1 - 0.0038 17.1 0.0 0.0051 16.7 0.0 1.1 1 0 0 1 1 1 1 PAC2 family Phage_int_SAM_3 PF14659.1 KII71486.1 - 0.0073 16.5 0.2 6 7.2 0.0 2.6 2 1 0 2 2 2 2 Phage integrase, N-terminal SAM-like domain RNase_P_p30 PF01876.11 KII71487.1 - 5.9e-31 106.7 0.0 8.6e-31 106.2 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 Ribosomal_L13 PF00572.13 KII71488.1 - 1.2e-23 83.5 0.9 2.4e-23 82.5 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L13 PhosphMutase PF10143.4 KII71490.1 - 0.062 12.9 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 4HBT_2 PF13279.1 KII71493.1 - 0.044 14.2 0.1 0.056 13.8 0.1 1.3 1 1 0 1 1 1 0 Thioesterase-like superfamily MFS_Mycoplasma PF07672.8 KII71496.1 - 0.028 13.6 0.6 0.032 13.4 0.4 1.1 1 0 0 1 1 1 0 Mycoplasma MFS transporter DDE_Tnp_IS1595 PF12762.2 KII71499.1 - 3.5e-19 69.1 0.0 4.9e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Annexin PF00191.15 KII71500.1 - 3.9e-06 26.6 0.5 0.0021 17.9 0.2 2.2 2 0 0 2 2 2 2 Annexin Annexin PF00191.15 KII71501.1 - 0.038 13.8 0.0 0.42 10.5 0.0 2.1 2 0 0 2 2 2 0 Annexin Annexin PF00191.15 KII71502.1 - 2.7e-21 75.2 3.2 2.7e-09 36.8 0.0 4.3 4 1 0 4 4 4 3 Annexin GvpO PF05800.6 KII71502.1 - 0.098 12.5 0.0 0.64 9.9 0.0 2.1 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpO ABC_tran PF00005.22 KII71503.1 - 2.2e-05 24.7 0.0 2.7e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KII71503.1 - 0.0028 17.6 1.4 0.005 16.8 0.9 1.5 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 KII71503.1 - 0.038 13.2 0.0 0.049 12.8 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain MA-Mit PF09245.5 KII71503.1 - 0.073 12.3 0.1 0.089 12.0 0.0 1.1 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen IBN_N PF03810.14 KII71508.1 - 0.00014 21.7 0.6 0.035 14.0 0.1 2.7 2 0 0 2 2 2 2 Importin-beta N-terminal domain TGT PF01702.13 KII71508.1 - 0.017 14.3 0.1 0.036 13.3 0.0 1.5 2 0 0 2 2 2 0 Queuine tRNA-ribosyltransferase DUF964 PF06133.6 KII71508.1 - 0.11 12.4 0.8 13 5.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF964) DUF2621 PF11084.3 KII71509.1 - 0.021 14.5 0.7 0.039 13.6 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2621) Ldl_recept_a PF00057.13 KII71511.1 - 7e-08 32.2 7.8 9.6e-08 31.7 5.4 1.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Imm20 PF15568.1 KII71512.1 - 0.028 14.2 0.1 0.06 13.2 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 20 Sipho_Gp157 PF05565.6 KII71512.1 - 0.2 11.1 3.2 0.39 10.2 0.3 2.1 2 0 0 2 2 2 0 Siphovirus Gp157 F420_oxidored PF03807.12 KII71514.1 - 1.3e-17 63.9 0.0 2.2e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 KII71514.1 - 2.8e-10 40.2 0.0 4.8e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.11 KII71514.1 - 2e-05 24.0 0.1 2.9e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.14 KII71514.1 - 6.1e-05 22.2 0.1 0.00014 21.0 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 KII71514.1 - 0.00039 20.4 0.1 0.0006 19.8 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Rossmann-like PF10727.4 KII71514.1 - 0.00065 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Rossmann-like domain GFO_IDH_MocA PF01408.17 KII71514.1 - 0.0012 19.3 0.1 0.071 13.6 0.1 2.3 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold IlvN PF07991.7 KII71514.1 - 0.0018 17.6 0.0 0.008 15.5 0.0 1.9 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain UDPG_MGDP_dh_N PF03721.9 KII71514.1 - 0.0018 17.6 0.1 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.18 KII71514.1 - 0.0043 16.7 1.2 0.014 15.1 0.9 1.9 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.13 KII71514.1 - 0.0073 16.2 0.3 0.023 14.6 0.2 1.8 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_7 PF13241.1 KII71514.1 - 0.0074 16.5 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding DEDD_Tnp_IS110 PF01548.12 KII71514.1 - 0.012 15.2 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Transposase Pyr_redox PF00070.22 KII71514.1 - 0.032 14.6 0.2 0.073 13.4 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 KII71514.1 - 0.036 13.7 0.3 0.054 13.1 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 KII71514.1 - 0.048 13.9 0.2 0.11 12.7 0.2 1.6 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 KII71514.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short PF00106.20 KII71514.1 - 0.12 12.2 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 short chain dehydrogenase HxlR PF01638.12 KII71515.1 - 7.1e-30 102.4 0.3 9.2e-30 102.1 0.2 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.9 KII71515.1 - 0.00059 19.5 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_5 PF01022.15 KII71515.1 - 0.017 14.7 0.1 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_20 PF12840.2 KII71515.1 - 0.06 13.1 0.0 0.14 11.9 0.0 1.6 1 1 1 2 2 2 0 Helix-turn-helix domain MarR PF01047.17 KII71515.1 - 0.08 12.6 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 MarR family RVT_1 PF00078.22 KII71518.1 - 4.2e-17 62.2 0.0 1e-16 60.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.22 KII71520.1 - 0.0067 15.8 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) THDPS_N PF14790.1 KII71521.1 - 0.014 15.0 0.2 0.015 14.9 0.2 1.1 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Nucleoside_tran PF01733.13 KII71522.1 - 3.2e-06 26.5 0.3 3.2e-06 26.5 0.2 1.9 1 1 0 2 2 2 1 Nucleoside transporter DUF3989 PF13150.1 KII71523.1 - 0.0061 15.9 0.2 0.018 14.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3989) Col_cuticle_N PF01484.12 KII71523.1 - 1.3 8.7 6.0 0.22 11.2 0.4 2.4 3 0 0 3 3 3 0 Nematode cuticle collagen N-terminal domain rve PF00665.21 KII71526.1 - 2.8e-22 79.0 0.0 4.9e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71526.1 - 0.00092 18.6 0.1 0.0048 16.3 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain LOH1CR12 PF10158.4 KII71528.1 - 0.16 11.7 0.9 0.73 9.6 0.6 2.0 1 1 0 1 1 1 0 Tumour suppressor protein Homez PF11569.3 KII71529.1 - 0.0057 15.6 0.0 0.011 14.7 0.0 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Homeobox PF00046.24 KII71529.1 - 0.095 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Homeobox domain rve PF00665.21 KII71530.1 - 2.6e-06 27.5 0.0 0.00011 22.2 0.0 2.3 1 1 1 2 2 2 2 Integrase core domain rve_3 PF13683.1 KII71530.1 - 0.00054 19.4 0.0 0.0011 18.4 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII71532.1 - 2.1e-11 43.5 0.1 3.1e-11 43.0 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2513 PF10711.4 KII71532.1 - 0.023 14.7 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) HTH_20 PF12840.2 KII71532.1 - 0.072 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain PCI PF01399.22 KII71534.1 - 6.3e-16 58.6 1.2 2.4e-15 56.7 0.1 2.5 3 1 0 3 3 3 1 PCI domain TPR_12 PF13424.1 KII71534.1 - 0.0029 17.5 0.5 0.92 9.4 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII71534.1 - 0.022 14.6 0.3 25 5.1 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.1 KII71534.1 - 0.12 11.4 2.0 0.41 9.7 0.2 2.3 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP DDE_Tnp_IS1595 PF12762.2 KII71535.1 - 0.002 17.9 0.0 0.0084 15.9 0.0 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF1581 PF07619.6 KII71535.1 - 0.084 12.8 0.3 2.7 8.0 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1581) BBS2_Mid PF14783.1 KII71536.1 - 0.00064 19.4 0.0 0.026 14.3 0.0 2.4 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Ldl_recept_a PF00057.13 KII71537.1 - 2.1e-48 161.9 128.9 5.5e-10 38.9 7.0 8.8 8 1 0 8 8 8 7 Low-density lipoprotein receptor domain class A MMR_HSR1 PF01926.18 KII71538.1 - 1.7e-17 63.4 0.0 3.9e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KII71538.1 - 1.1e-11 44.8 0.4 2.8e-06 27.2 0.0 2.4 1 1 1 2 2 2 2 Dynamin family FeoB_N PF02421.13 KII71538.1 - 1.5e-09 37.2 0.0 2.6e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 KII71538.1 - 1.1e-05 25.9 0.0 2.2e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein ArgK PF03308.11 KII71538.1 - 0.0015 17.3 0.0 0.09 11.5 0.0 2.1 2 0 0 2 2 2 1 ArgK protein GTP_EFTU PF00009.22 KII71538.1 - 0.0023 17.4 0.0 0.69 9.3 0.0 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.11 KII71538.1 - 0.0028 16.7 0.0 0.0046 16.0 0.0 1.3 1 0 0 1 1 1 1 AIG1 family DUF258 PF03193.11 KII71538.1 - 0.0057 15.8 0.0 0.012 14.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 KII71538.1 - 0.031 14.5 0.0 0.057 13.7 0.0 1.4 1 1 0 1 1 1 0 ABC transporter G-alpha PF00503.15 KII71538.1 - 0.041 12.5 0.3 9.5 4.7 0.0 2.8 3 0 0 3 3 3 0 G-protein alpha subunit RRM_1 PF00076.17 KII71539.1 - 1e-05 25.0 0.1 0.16 11.6 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII71539.1 - 0.00025 20.8 0.0 0.85 9.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) P22_AR_N PF10547.4 KII71539.1 - 0.0069 16.1 0.2 1.1 9.0 0.0 2.4 2 0 0 2 2 2 2 P22_AR N-terminal domain RRM_6 PF14259.1 KII71539.1 - 0.0099 15.8 0.1 0.92 9.5 0.0 2.8 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CR6_interact PF10147.4 KII71539.1 - 0.012 14.8 1.7 0.019 14.3 0.6 1.6 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 USP7_ICP0_bdg PF12436.3 KII71541.1 - 0.026 13.7 0.2 1.6 7.8 0.0 2.2 2 0 0 2 2 2 0 ICP0-binding domain of Ubiquitin-specific protease 7 RNA_binding PF01877.12 KII71541.1 - 0.14 12.1 1.0 0.42 10.6 0.2 2.1 2 0 0 2 2 2 0 RNA binding RNA_pol_Rpb5_C PF01191.14 KII71545.1 - 1.1e-34 117.8 0.7 1.9e-34 117.0 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 KII71545.1 - 1.2e-26 92.9 0.9 2.1e-26 92.1 0.6 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain IBN_N PF03810.14 KII71546.1 - 0.021 14.7 0.0 0.054 13.4 0.0 1.7 1 0 0 1 1 1 0 Importin-beta N-terminal domain UME PF08064.8 KII71546.1 - 0.053 13.4 0.1 0.14 12.0 0.1 1.8 1 0 0 1 1 1 0 UME (NUC010) domain RIX1 PF08167.7 KII71546.1 - 0.1 12.2 0.2 0.87 9.2 0.0 2.3 1 1 1 2 2 2 0 rRNA processing/ribosome biogenesis HEAT_2 PF13646.1 KII71548.1 - 1.2e-06 28.7 0.0 0.018 15.3 0.0 3.7 2 2 1 3 3 3 2 HEAT repeats HEAT PF02985.17 KII71548.1 - 0.00041 20.1 1.9 0.1 12.7 0.0 4.5 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 KII71548.1 - 0.0027 18.1 0.1 0.93 10.0 0.0 4.0 4 1 1 5 5 5 1 HEAT-like repeat B56 PF01603.15 KII71548.1 - 0.0046 15.6 0.0 0.009 14.6 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Vac14_Fab1_bd PF12755.2 KII71548.1 - 0.057 13.8 1.3 11 6.4 0.1 3.1 2 2 1 3 3 3 0 Vacuolar 14 Fab1-binding region DRIM PF07539.7 KII71548.1 - 0.1 11.9 0.0 3.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Down-regulated in metastasis NIF PF03031.13 KII71549.1 - 0.045 13.4 0.2 0.12 12.0 0.1 1.7 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase DUF2669 PF10876.3 KII71549.1 - 0.058 13.1 0.2 1.6 8.4 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2669) HEAT_2 PF13646.1 KII71550.1 - 1.9e-06 28.0 0.0 0.039 14.2 0.0 3.7 2 2 1 3 3 3 2 HEAT repeats HEAT PF02985.17 KII71550.1 - 0.00015 21.5 3.2 0.025 14.6 0.0 4.7 5 1 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 KII71550.1 - 0.00094 19.6 0.1 0.39 11.2 0.0 4.1 4 2 1 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KII71550.1 - 0.1 12.9 2.2 11 6.4 0.1 3.2 2 2 1 3 3 3 0 Vacuolar 14 Fab1-binding region NIF PF03031.13 KII71551.1 - 0.017 14.8 0.3 0.15 11.7 0.1 2.4 1 1 1 2 2 2 0 NLI interacting factor-like phosphatase Integrin_beta PF00362.13 KII71553.1 - 1.7e-39 135.9 0.4 2.6e-39 135.3 0.3 1.2 1 0 0 1 1 1 1 Integrin, beta chain EGF_2 PF07974.8 KII71553.1 - 4.6e-05 23.4 14.9 4.6e-05 23.4 10.4 3.6 3 1 0 3 3 3 2 EGF-like domain DUF3023 PF11224.3 KII71553.1 - 0.012 15.2 0.9 0.034 13.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3023) NEAT PF05031.7 KII71553.1 - 0.33 10.9 3.4 0.32 11.0 0.7 2.0 2 0 0 2 2 2 0 Iron Transport-associated domain rve PF00665.21 KII71554.1 - 2.8e-22 79.0 0.0 4.7e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71554.1 - 0.0013 18.2 0.6 0.0029 17.0 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS1595 PF12762.2 KII71555.1 - 1.5e-15 57.3 0.1 1.7e-15 57.1 0.1 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII71555.1 - 0.1 11.7 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family zf-BED PF02892.10 KII71556.1 - 0.13 12.0 1.0 0.23 11.2 0.7 1.4 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_jaz PF12171.3 KII71556.1 - 0.36 11.0 2.8 1.1 9.5 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding SCO1-SenC PF02630.9 KII71557.1 - 0.025 14.2 0.1 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 SCO1/SenC BNR PF02012.15 KII71559.1 - 1e-05 24.6 1.1 0.23 11.4 0.0 3.8 3 0 0 3 3 3 3 BNR/Asp-box repeat Borrelia_orfX PF04160.7 KII71560.1 - 0.17 11.7 2.4 0.27 11.0 1.6 1.5 1 1 0 1 1 1 0 Orf-X protein Peptidase_M7 PF02031.11 KII71564.1 - 0.071 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family DUF4371 PF14291.1 KII71567.1 - 0.083 12.4 0.4 0.13 11.7 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) DDE_3 PF13358.1 KII71569.1 - 8.2e-21 74.2 0.1 8.8e-21 74.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease XFP PF03894.10 KII71569.1 - 0.035 13.7 0.0 0.038 13.5 0.0 1.1 1 0 0 1 1 1 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase DDE_1 PF03184.14 KII71569.1 - 0.13 11.3 0.0 0.15 11.2 0.0 1.0 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_29 PF13551.1 KII71570.1 - 0.016 15.3 0.4 0.05 13.7 0.1 2.0 2 1 1 3 3 3 0 Winged helix-turn helix Baculo_ODV-E27 PF05314.6 KII71570.1 - 0.019 14.0 0.3 0.026 13.5 0.2 1.2 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 Herpes_BLRF2 PF05812.7 KII71570.1 - 0.022 14.5 0.4 0.05 13.4 0.1 1.6 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein HTH_38 PF13936.1 KII71570.1 - 0.039 13.5 0.3 39 3.9 0.0 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain Lambda_CIII PF02061.11 KII71570.1 - 0.045 13.7 0.3 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 Lambda Phage CIII Syntaxin_2 PF14523.1 KII71570.1 - 0.095 12.7 0.4 0.54 10.3 0.0 2.1 2 0 0 2 2 2 0 Syntaxin-like protein HTH_23 PF13384.1 KII71570.1 - 0.54 9.9 2.9 5.8 6.7 0.2 2.9 2 1 0 2 2 2 0 Homeodomain-like domain DDE_Tnp_IS1595 PF12762.2 KII71573.1 - 0.00019 21.3 0.8 0.022 14.5 0.1 2.4 1 1 1 2 2 2 2 ISXO2-like transposase domain PufQ PF05398.6 KII71575.1 - 0.025 14.6 0.2 0.044 13.8 0.1 1.3 1 0 0 1 1 1 0 PufQ cytochrome subunit FtsL PF04999.8 KII71576.1 - 0.054 13.2 0.6 0.054 13.2 0.4 2.3 2 1 1 3 3 3 0 Cell division protein FtsL AIG1 PF04548.11 KII71576.1 - 0.054 12.5 0.0 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 AIG1 family AA_permease PF00324.16 KII71576.1 - 0.075 11.3 10.4 0.047 12.0 4.6 2.3 1 1 1 2 2 2 0 Amino acid permease ICMT PF04140.9 KII71576.1 - 0.18 12.0 7.3 0.098 12.8 1.1 2.4 1 1 1 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ABC2_membrane_3 PF12698.2 KII71576.1 - 0.39 9.7 11.1 1.5 7.8 7.7 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF1772 PF08592.6 KII71576.1 - 4.4 7.0 8.7 1.9 8.2 3.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) zinc_ribbon_2 PF13240.1 KII71579.1 - 0.24 10.9 2.5 11 5.7 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-CCHC PF00098.18 KII71579.1 - 0.34 10.9 8.2 0.41 10.6 1.1 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII71579.1 - 0.64 9.7 4.1 0.24 11.0 0.4 2.2 2 0 0 2 2 2 0 Zinc knuckle DZR PF12773.2 KII71579.1 - 2.2 8.1 7.1 15 5.5 4.9 2.2 1 1 0 1 1 1 0 Double zinc ribbon rve PF00665.21 KII71580.1 - 4.8e-14 52.4 0.0 8.2e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71580.1 - 0.00079 18.8 0.1 0.0017 17.8 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain cNMP_binding PF00027.24 KII71582.1 - 0.02 14.7 0.0 0.029 14.1 0.0 1.4 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain HTH_33 PF13592.1 KII71583.1 - 1.1e-06 28.0 0.1 2.6e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII71583.1 - 0.0057 16.6 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 KII71583.1 - 0.096 13.4 0.0 0.16 12.7 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain HTH_23 PF13384.1 KII71583.1 - 0.11 12.1 0.2 0.26 11.0 0.2 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Peptidase_U40 PF10464.4 KII71586.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase U40 DCAF15_WD40 PF14939.1 KII71587.1 - 0.038 13.3 0.0 0.045 13.0 0.0 1.2 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat rve PF00665.21 KII71590.1 - 4.7e-29 100.9 0.0 1.4e-28 99.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII71590.1 - 9.6e-21 74.1 0.1 2.2e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII71590.1 - 3.8e-08 33.1 0.0 1.2e-07 31.5 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.5 KII71590.1 - 3.6e-06 26.2 1.2 9.7e-06 24.9 0.8 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger zf-CCHC PF00098.18 KII71590.1 - 0.0001 22.0 11.8 0.0055 16.5 1.9 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII71590.1 - 0.00054 20.4 0.0 0.0015 19.0 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII71590.1 - 0.0014 18.2 0.1 0.0037 16.8 0.1 1.8 1 1 0 1 1 1 1 Aspartyl protease rve_3 PF13683.1 KII71590.1 - 0.0028 17.1 0.0 0.0096 15.4 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_3 PF13917.1 KII71590.1 - 0.01 15.5 5.6 0.033 13.9 0.3 2.5 1 1 1 2 2 2 1 Zinc knuckle Herpes_UL14 PF03580.9 KII71590.1 - 0.052 13.3 0.1 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL14-like protein gag-asp_proteas PF13975.1 KII71590.1 - 0.06 13.1 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII71590.1 - 0.086 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-ribbon_3 PF13248.1 KII71590.1 - 0.18 11.0 4.0 0.4 9.9 2.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-CCHC_4 PF14392.1 KII71590.1 - 7 6.4 12.1 0.35 10.5 0.6 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_5 PF14787.1 KII71590.1 - 8 6.0 14.0 0.36 10.3 0.7 3.3 2 1 1 3 3 3 0 GAG-polyprotein viral zinc-finger ECH_C PF13766.1 KII71591.1 - 1.4e-21 76.8 0.0 2.3e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 KII71591.1 - 3.1e-18 65.7 0.0 5.9e-17 61.6 0.0 2.5 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase family GDI PF00996.13 KII71592.1 - 0.044 12.1 0.3 0.052 11.8 0.2 1.1 1 0 0 1 1 1 0 GDP dissociation inhibitor Phage_GP20 PF06810.6 KII71592.1 - 0.098 12.0 0.2 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF4441 PF14536.1 KII71592.1 - 0.16 11.9 3.1 0.22 11.4 1.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4441) HLH PF00010.21 KII71593.1 - 1e-10 41.1 1.4 1e-10 41.1 1.0 2.9 3 1 0 3 3 3 1 Helix-loop-helix DNA-binding domain HBS1_N PF08938.5 KII71593.1 - 0.017 15.1 0.2 0.029 14.4 0.0 1.7 2 0 0 2 2 2 0 HBS1 N-terminus Pkinase PF00069.20 KII71594.1 - 3.7e-45 154.1 0.2 1e-44 152.6 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII71594.1 - 1.6e-27 96.2 0.0 2.5e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII71594.1 - 7.1e-05 21.8 0.0 0.00014 20.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KII71594.1 - 0.014 14.4 0.1 0.032 13.3 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 KII71594.1 - 0.086 12.4 6.2 0.019 14.5 1.3 2.1 2 1 0 2 2 2 0 Choline/ethanolamine kinase XPG_I PF00867.13 KII71596.1 - 1.8e-22 79.2 0.2 3.8e-22 78.1 0.0 1.6 2 0 0 2 2 2 1 XPG I-region PDZ PF00595.19 KII71597.1 - 0.0026 17.9 0.0 0.0041 17.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RICTOR_N PF14664.1 KII71597.1 - 0.0033 16.0 0.0 0.004 15.7 0.0 1.1 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term DUF3557 PF12078.3 KII71598.1 - 0.078 12.6 3.5 0.76 9.4 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3557) KA1 PF02149.14 KII71598.1 - 0.16 11.4 0.9 0.39 10.2 0.0 2.0 2 0 0 2 2 2 0 Kinase associated domain 1 MutS_II PF05188.12 KII71599.1 - 0.00056 19.9 0.1 0.00073 19.6 0.0 1.2 1 0 0 1 1 1 1 MutS domain II Myosin_head PF00063.16 KII71601.1 - 1.7e-225 750.2 0.1 2.8e-225 749.5 0.1 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 KII71601.1 - 5.4e-16 58.5 1.3 9.9e-16 57.6 0.9 1.4 1 0 0 1 1 1 1 Myosin tail AAA_22 PF13401.1 KII71601.1 - 0.0016 18.5 0.2 0.0054 16.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 KII71601.1 - 0.028 14.0 0.2 5.3 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 KII71601.1 - 0.035 13.0 0.0 0.069 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.1 KII71601.1 - 0.049 13.6 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain T2SE PF00437.15 KII71601.1 - 0.11 11.3 0.0 0.27 10.1 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein SH3_1 PF00018.23 KII71602.1 - 6.4e-18 63.8 0.3 1e-17 63.2 0.2 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 KII71602.1 - 1.1e-16 60.1 0.1 1.7e-16 59.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KII71602.1 - 3.7e-15 55.1 0.0 5.7e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Myosin_TH1 PF06017.8 KII71602.1 - 5.6e-06 25.8 1.2 5.6e-06 25.8 0.8 1.7 1 1 1 2 2 2 1 Myosin tail Fimbrial_K88 PF02432.10 KII71602.1 - 0.00091 18.7 1.3 0.0012 18.3 0.9 1.1 1 0 0 1 1 1 1 Fimbrial, major and minor subunit DDE_Tnp_IS1595 PF12762.2 KII71603.1 - 2.1e-16 60.1 0.0 2.4e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF4650 PF15509.1 KII71603.1 - 0.042 12.7 0.1 0.044 12.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) Homeobox PF00046.24 KII71605.1 - 5.1e-16 58.0 6.0 1.1e-15 56.9 4.1 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KII71605.1 - 0.0081 15.8 2.6 0.02 14.6 1.8 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.3 KII71605.1 - 0.033 13.2 0.1 0.084 11.9 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HTH_26 PF13443.1 KII71605.1 - 0.085 13.0 0.4 0.39 10.9 0.1 2.2 3 0 0 3 3 3 0 Cro/C1-type HTH DNA-binding domain DUF708 PF05341.6 KII71605.1 - 1 9.1 4.4 0.56 10.0 0.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF708) Phage_holin PF04688.8 KII71607.1 - 0.098 12.1 0.0 6 6.4 0.0 2.9 3 0 0 3 3 3 0 Phage lysis protein, holin Exo70 PF03081.10 KII71608.1 - 3.6e-11 42.4 0.4 3.8e-11 42.3 0.2 1.0 1 0 0 1 1 1 1 Exo70 exocyst complex subunit DUF2151 PF10221.4 KII71608.1 - 0.0046 15.1 0.2 0.0055 14.9 0.1 1.1 1 0 0 1 1 1 1 Cell cycle and development regulator YxiJ PF14176.1 KII71608.1 - 0.053 13.6 2.8 0.72 10.0 0.3 2.2 1 1 1 2 2 2 0 YxiJ-like protein DUF2283 PF10049.4 KII71609.1 - 0.33 10.8 2.0 3.6 7.5 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2283) E1_dh PF00676.15 KII71611.1 - 1.8e-88 296.1 0.1 2.4e-87 292.4 0.1 1.9 1 1 0 1 1 1 1 Dehydrogenase E1 component RRM_1 PF00076.17 KII71612.1 - 0.0017 17.9 0.0 0.0035 16.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII71612.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pox_A51 PF04948.8 KII71613.1 - 0.0079 14.9 0.7 0.01 14.5 0.5 1.1 1 0 0 1 1 1 1 Poxvirus A51 protein HalX PF08663.5 KII71613.1 - 0.017 15.1 1.4 1 9.3 0.0 3.0 1 1 2 3 3 3 0 HalX domain GIT_SHD PF08518.6 KII71613.1 - 0.42 10.0 4.0 0.81 9.0 0.1 2.8 3 0 0 3 3 3 0 Spa2 homology domain (SHD) of GIT FANCI_S3 PF14677.1 KII71615.1 - 0.0068 15.8 0.6 0.0085 15.4 0.4 1.1 1 0 0 1 1 1 1 FANCI solenoid 3 PRANC PF09372.5 KII71615.1 - 0.032 14.1 3.0 0.079 12.9 1.5 2.0 1 1 1 2 2 2 0 PRANC domain HSL_N PF06350.7 KII71615.1 - 0.06 12.4 0.1 0.078 12.0 0.0 1.1 1 0 0 1 1 1 0 Hormone-sensitive lipase (HSL) N-terminus DnaA_N PF11638.3 KII71615.1 - 0.11 12.0 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 DnaA N-terminal domain FERM_N PF09379.5 KII71617.1 - 6.7e-18 64.5 1.6 5.3e-17 61.6 0.8 2.5 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.13 KII71617.1 - 1.9e-12 47.4 0.2 3.9e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.5 KII71617.1 - 2.3e-09 37.3 0.0 5.3e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.6 KII71617.1 - 0.062 13.0 0.6 0.23 11.2 0.4 1.9 1 0 0 1 1 1 0 FERM adjacent (FA) IU_nuc_hydro PF01156.14 KII71618.1 - 4.8e-16 58.8 0.0 5.3e-16 58.7 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase EF-hand_7 PF13499.1 KII71620.1 - 3.6e-20 71.8 1.9 1.5e-12 47.4 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KII71620.1 - 1.6e-15 55.1 0.5 6.4e-05 21.9 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KII71620.1 - 5.9e-14 50.6 0.6 4.6e-05 22.9 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KII71620.1 - 1.3e-11 43.9 0.4 3.2e-08 33.0 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KII71620.1 - 2.6e-07 29.6 1.3 0.00038 19.6 0.1 3.7 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.4 KII71620.1 - 9e-05 22.4 0.0 0.018 15.0 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KII71620.1 - 0.00012 21.8 0.1 0.00061 19.6 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain DHOase PF12890.2 KII71620.1 - 0.0033 17.1 0.0 0.0047 16.6 0.0 1.2 1 0 0 1 1 1 1 Dihydro-orotase-like RST PF12174.3 KII71620.1 - 0.0066 16.2 0.3 0.034 13.9 0.0 2.3 2 1 1 3 3 3 1 RCD1-SRO-TAF4 (RST) plant domain EF-hand_like PF09279.6 KII71620.1 - 0.0075 16.2 0.4 0.8 9.7 0.0 2.5 3 0 0 3 3 3 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_4 PF12763.2 KII71620.1 - 0.067 12.9 0.1 0.2 11.3 0.1 1.8 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Helicase_C PF00271.26 KII71621.1 - 4.1e-21 74.6 0.1 6.3e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ribosomal_S4 PF00163.14 KII71622.1 - 5.3e-23 81.2 1.2 5.3e-23 81.2 0.8 1.9 3 0 0 3 3 3 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 KII71622.1 - 4.4e-11 42.0 0.5 1.1e-10 40.7 0.3 1.7 1 0 0 1 1 1 1 S4 domain DDE_1 PF03184.14 KII71623.1 - 9.1e-06 24.9 0.8 0.0044 16.1 0.2 2.7 1 1 2 3 3 3 2 DDE superfamily endonuclease CENP-B_dimeris PF09026.5 KII71623.1 - 0.017 15.3 0.0 0.033 14.4 0.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3515 PF12028.3 KII71624.1 - 0.0024 17.1 0.0 0.67 9.1 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3515) LIP PF03583.9 KII71625.1 - 0.12 11.6 0.0 0.13 11.4 0.0 1.0 1 0 0 1 1 1 0 Secretory lipase DDE_Tnp_IS1595 PF12762.2 KII71627.1 - 1.6e-06 28.0 0.0 3e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.2 KII71630.1 - 1.5e-06 28.1 0.9 2e-06 27.7 0.7 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Leu_Phe_trans PF03588.9 KII71630.1 - 0.043 12.9 1.2 2.9 7.0 0.1 2.1 2 0 0 2 2 2 0 Leucyl/phenylalanyl-tRNA protein transferase Dimer_Tnp_hAT PF05699.9 KII71631.1 - 1.4e-06 27.8 0.1 2.8e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ribosomal_S17 PF00366.15 KII71635.1 - 1.8e-25 88.7 3.5 3.3e-25 87.9 2.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 DUF1064 PF06356.6 KII71635.1 - 0.022 14.7 0.1 0.038 13.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1064) DDE_3 PF13358.1 KII71638.1 - 3.8e-08 33.2 0.0 4.4e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 KII71639.1 - 3.9e-12 45.3 0.5 4.2e-08 32.5 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII71639.1 - 2.3e-10 40.2 0.3 5.2e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_29 PF13551.1 KII71639.1 - 3.1e-09 36.9 0.5 9.1e-09 35.4 0.2 1.7 1 1 1 2 2 2 1 Winged helix-turn helix PAX PF00292.13 KII71639.1 - 4.4e-08 32.8 0.2 5.6e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_38 PF13936.1 KII71639.1 - 7e-07 28.6 1.3 5e-05 22.7 0.4 2.7 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.1 KII71639.1 - 2.5e-06 26.5 1.7 3.9e-05 22.7 0.0 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 DUF1323 PF07037.6 KII71639.1 - 7.1e-06 26.2 0.3 1.4e-05 25.2 0.2 1.6 1 1 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_Tnp_1 PF01527.15 KII71639.1 - 1.7e-05 24.7 0.2 2.9e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Transposase HTH_Tnp_IS630 PF01710.11 KII71639.1 - 2.1e-05 24.1 0.2 3.2e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Transposase Bot1p PF12298.3 KII71639.1 - 2.4e-05 24.3 1.1 2.9e-05 24.0 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein HTH_32 PF13565.1 KII71639.1 - 2.6e-05 24.9 0.4 0.00039 21.1 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.8 KII71639.1 - 3e-05 23.3 0.9 0.00012 21.4 0.1 2.2 2 1 1 3 3 2 1 CENP-B N-terminal DNA-binding domain HTH_33 PF13592.1 KII71639.1 - 0.00018 20.9 0.0 0.00041 19.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_24 PF13412.1 KII71639.1 - 0.00018 20.7 0.4 0.097 12.0 0.1 2.4 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Tnp_Tc3_2 PF01498.13 KII71639.1 - 0.0002 21.3 0.8 0.0035 17.3 0.0 2.4 2 1 0 2 2 2 1 Transposase Arg_repressor PF01316.16 KII71639.1 - 0.00045 19.7 1.1 0.00086 18.8 0.0 1.9 2 1 1 3 3 3 1 Arginine repressor, DNA binding domain LacI PF00356.16 KII71639.1 - 0.00046 19.7 1.0 1.3 8.6 0.0 3.7 4 0 0 4 4 4 1 Bacterial regulatory proteins, lacI family HTH_17 PF12728.2 KII71639.1 - 0.00091 19.4 0.0 0.2 11.9 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.17 KII71639.1 - 0.0012 18.6 0.0 0.019 14.8 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.1 KII71639.1 - 0.002 17.8 0.6 0.091 12.5 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.10 KII71639.1 - 0.004 16.9 1.7 0.21 11.4 0.2 2.6 2 2 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_40 PF14493.1 KII71639.1 - 0.0054 16.9 0.1 0.011 15.9 0.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 KII71639.1 - 0.0082 15.8 0.2 0.056 13.1 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB SpoIIID PF12116.3 KII71639.1 - 0.016 15.1 1.3 0.18 11.7 0.7 2.3 1 1 0 1 1 1 0 Stage III sporulation protein D Sigma70_r4 PF04545.11 KII71639.1 - 0.021 14.1 0.1 0.05 12.9 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 DUF2666 PF10869.3 KII71639.1 - 0.022 14.8 0.1 0.027 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) HTH_psq PF05225.11 KII71639.1 - 0.028 13.9 0.0 0.064 12.8 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_DeoR PF08220.7 KII71639.1 - 0.032 13.7 0.9 0.2 11.2 0.1 2.3 2 1 0 2 2 2 0 DeoR-like helix-turn-helix domain Sigma70_r4_2 PF08281.7 KII71639.1 - 0.032 13.6 0.0 0.28 10.6 0.0 2.2 2 1 0 2 2 2 0 Sigma-70, region 4 MCR_C PF04609.7 KII71639.1 - 0.033 13.0 0.7 0.038 12.7 0.5 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C HTH_11 PF08279.7 KII71639.1 - 0.038 13.6 1.0 0.096 12.3 0.0 2.2 3 0 0 3 3 2 0 HTH domain Prenyltransf PF01255.14 KII71639.1 - 0.078 12.0 0.2 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase HTH_WhiA PF02650.9 KII71639.1 - 0.09 13.1 0.1 0.86 10.0 0.0 2.0 2 0 0 2 2 2 0 WhiA C-terminal HTH domain FliG_N PF14842.1 KII71639.1 - 0.095 12.8 0.0 0.28 11.2 0.0 1.9 1 1 1 2 2 2 0 FliG N-terminal domain TFIIE_beta PF02186.10 KII71639.1 - 0.099 12.6 0.4 0.22 11.5 0.1 1.7 2 0 0 2 2 2 0 TFIIE beta subunit core domain MarR_2 PF12802.2 KII71639.1 - 0.13 11.9 0.0 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 MarR family Glycophorin_A PF01102.13 KII71640.1 - 0.0062 16.2 0.3 0.01 15.5 0.2 1.4 1 0 0 1 1 1 1 Glycophorin A DDE_3 PF13358.1 KII71640.1 - 0.065 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease EphA2_TM PF14575.1 KII71640.1 - 0.11 12.8 0.1 0.28 11.6 0.1 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain HTH_32 PF13565.1 KII71644.1 - 6.2e-10 39.7 0.0 7.9e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 KII71644.1 - 2.9e-07 30.6 0.0 3e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII71644.1 - 0.0033 17.0 0.0 0.2 11.3 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.1 KII71644.1 - 0.0039 16.7 0.0 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix Rep_3 PF01051.16 KII71644.1 - 0.0053 16.3 0.2 0.0058 16.2 0.1 1.1 1 0 0 1 1 1 1 Initiator Replication protein HTH_Tnp_Tc3_2 PF01498.13 KII71644.1 - 0.0061 16.6 0.1 0.036 14.1 0.0 2.1 2 0 0 2 2 2 1 Transposase HTH_28 PF13518.1 KII71644.1 - 0.007 16.3 0.1 0.14 12.1 0.1 2.2 2 1 0 2 2 2 1 Helix-turn-helix domain Toxin_64 PF15542.1 KII71644.1 - 0.051 14.1 4.0 0.82 10.2 0.5 2.4 1 1 1 2 2 2 0 Putative toxin 64 DEK_C PF08766.6 KII71644.1 - 0.13 12.0 0.6 2.2 8.1 0.0 2.5 3 0 0 3 3 3 0 DEK C terminal domain P_proprotein PF01483.15 KII71647.1 - 3.3e-24 84.4 0.0 5.3e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Ank_4 PF13637.1 KII71648.1 - 0.0031 17.9 0.6 0.22 12.1 0.1 3.0 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 KII71648.1 - 0.0054 16.9 0.8 0.37 11.1 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) PDZ PF00595.19 KII71648.1 - 0.013 15.6 0.5 0.03 14.4 0.0 1.9 2 0 0 2 2 2 0 PDZ domain (Also known as DHR or GLGF) Ank_2 PF12796.2 KII71648.1 - 0.032 14.5 2.0 0.29 11.4 1.4 2.3 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KII71648.1 - 0.75 10.2 3.3 30 5.2 0.1 3.4 3 0 0 3 3 3 0 Ankyrin repeat Ldl_recept_a PF00057.13 KII71650.1 - 0.00035 20.4 9.5 0.00042 20.1 5.9 1.6 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A CwfJ_C_2 PF04676.9 KII71653.1 - 0.035 14.6 0.2 7.1 7.1 0.0 2.3 1 1 1 2 2 2 0 Protein similar to CwfJ C-terminus 2 BNR PF02012.15 KII71654.1 - 0.0049 16.4 1.1 1.9 8.6 0.1 3.0 2 0 0 2 2 2 2 BNR/Asp-box repeat Mo-co_dimer PF03404.11 KII71654.1 - 0.069 12.7 0.0 1.5 8.4 0.0 2.4 2 0 0 2 2 2 0 Mo-co oxidoreductase dimerisation domain BNR_2 PF13088.1 KII71654.1 - 0.12 11.6 0.0 0.27 10.5 0.0 1.5 1 1 0 1 1 1 0 BNR repeat-like domain Ldl_recept_a PF00057.13 KII71655.1 - 1.3e-08 34.5 24.3 0.00028 20.7 4.3 2.5 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A CgtA PF06306.6 KII71655.1 - 0.0036 16.5 2.9 0.27 10.3 0.2 2.1 1 1 1 2 2 2 2 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA) PRKCSH-like PF12999.2 KII71655.1 - 0.049 13.2 15.2 0.062 12.8 10.5 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like MIG-14_Wnt-bd PF06664.7 KII71656.1 - 0.065 12.0 0.3 0.075 11.8 0.2 1.1 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Methylase_S PF01420.14 KII71657.1 - 0.066 13.1 1.7 5.7 6.8 0.1 2.0 1 1 1 2 2 2 0 Type I restriction modification DNA specificity domain Ldl_recept_a PF00057.13 KII71658.1 - 0.0008 19.2 8.1 0.0037 17.1 5.6 2.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII71660.1 - 2.3e-18 65.7 34.4 4.6e-10 39.2 9.5 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A IGFL PF14653.1 KII71660.1 - 0.17 11.9 10.1 0.16 11.9 6.3 1.5 1 1 0 1 1 1 0 Insulin growth factor-like family PyrI_C PF02748.10 KII71660.1 - 3.7 7.0 9.9 1.3 8.4 2.1 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF2270 PF10028.4 KII71663.1 - 0.011 15.1 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) DUF4371 PF14291.1 KII71664.1 - 2.5e-05 23.9 0.1 3.3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) CbiG_N PF11760.3 KII71665.1 - 0.081 12.6 0.0 0.87 9.3 0.0 2.2 2 0 0 2 2 2 0 Cobalamin synthesis G N-terminal Zn_Tnp_IS1595 PF12760.2 KII71666.1 - 0.064 13.0 1.0 0.12 12.1 0.7 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain MTS PF05175.9 KII71667.1 - 0.064 12.6 0.4 6.8 6.0 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase small domain tRNA-synt_1e PF01406.14 KII71667.1 - 0.068 12.2 0.1 9.5 5.2 0.0 2.3 2 1 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain DUF2673 PF10880.3 KII71667.1 - 0.12 12.4 0.9 6.6 6.8 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2673) DUF1359 PF07097.6 KII71669.1 - 0.12 12.3 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1359) FAD_binding_7 PF03441.9 KII71670.1 - 4.5e-31 108.0 1.0 1.3e-30 106.5 0.7 1.7 1 1 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 KII71670.1 - 1e-17 64.3 0.0 2.4e-17 63.1 0.0 1.6 2 0 0 2 2 2 1 DNA photolyase GRAS PF03514.9 KII71670.1 - 0.074 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 GRAS domain family zf-C2H2 PF00096.21 KII71671.1 - 3.7e-10 39.5 9.9 3.1e-05 24.0 1.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII71671.1 - 1.8e-08 34.1 13.2 0.00016 21.7 1.6 2.9 3 0 0 3 3 2 2 C2H2-type zinc finger zf-met PF12874.2 KII71671.1 - 2.9e-06 27.3 5.1 0.001 19.1 0.9 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 KII71671.1 - 1.8e-05 24.4 8.1 0.0017 18.1 0.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.2 KII71671.1 - 2.9e-05 24.0 3.7 0.041 13.9 0.2 2.3 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 KII71671.1 - 3.7e-05 23.7 5.5 0.019 15.1 0.4 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 KII71671.1 - 0.00033 20.8 9.9 1.1 9.6 2.5 4.1 4 1 0 4 4 4 2 Zinc-finger double domain zf-C2HC_2 PF13913.1 KII71671.1 - 0.0013 18.3 3.1 0.0013 18.3 2.2 2.9 3 0 0 3 3 3 1 zinc-finger of a C2HC-type zf-Di19 PF05605.7 KII71671.1 - 0.0081 16.2 2.4 0.33 11.1 0.1 2.4 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.1 KII71671.1 - 0.3 11.3 8.2 4.7 7.6 0.9 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain LIM PF00412.17 KII71671.1 - 0.78 9.8 5.1 2.1 8.4 0.3 2.4 1 1 1 2 2 2 0 LIM domain Elf1 PF05129.8 KII71671.1 - 0.94 9.2 5.1 8 6.2 3.5 2.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like Ldl_recept_a PF00057.13 KII71673.1 - 3.8e-06 26.6 15.7 7.6e-05 22.5 10.9 2.6 1 1 0 1 1 1 1 Low-density lipoprotein receptor domain class A DDE_3 PF13358.1 KII71674.1 - 6.1e-18 64.9 0.0 8.3e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII71674.1 - 3.3e-05 23.1 0.2 0.00038 19.6 0.0 2.1 1 1 1 2 2 2 1 DDE superfamily endonuclease BNR PF02012.15 KII71675.1 - 5.9e-05 22.3 0.8 0.26 11.2 0.0 3.1 3 0 0 3 3 3 2 BNR/Asp-box repeat AXE1 PF05448.7 KII71675.1 - 0.0051 15.3 0.1 0.0084 14.6 0.1 1.3 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) PTH2 PF01981.11 KII71679.1 - 1.4e-08 34.4 0.0 3.2e-08 33.2 0.0 1.5 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Sina PF03145.11 KII71680.1 - 3.4e-17 62.7 0.3 3.4e-17 62.7 0.2 2.0 1 1 1 2 2 2 1 Seven in absentia protein family PhnA_Zn_Ribbon PF08274.7 KII71680.1 - 0.29 10.9 0.0 0.29 10.9 0.0 2.8 3 0 0 3 3 3 0 PhnA Zinc-Ribbon zf-C3HC4_3 PF13920.1 KII71680.1 - 2.6 7.7 19.0 0.64 9.7 10.3 2.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.18 KII71681.1 - 5.9e-06 25.9 1.9 9.3e-06 25.3 1.3 1.3 1 0 0 1 1 1 1 Zinc knuckle GcrA PF07750.6 KII71681.1 - 0.063 13.4 0.0 0.13 12.4 0.0 1.4 1 1 0 1 1 1 0 GcrA cell cycle regulator zf-CCHC_4 PF14392.1 KII71681.1 - 0.12 12.0 1.2 0.25 11.0 0.9 1.6 1 0 0 1 1 1 0 Zinc knuckle RVT_1 PF00078.22 KII71683.1 - 9.3e-15 54.5 0.2 1.3e-14 54.0 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_IS1595 PF12762.2 KII71684.1 - 0.013 15.3 0.2 0.019 14.8 0.1 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain Fusion_gly PF00523.13 KII71684.1 - 0.072 11.1 0.1 0.12 10.3 0.0 1.3 1 0 0 1 1 1 0 Fusion glycoprotein F0 MOR2-PAG1_mid PF14228.1 KII71686.1 - 0.21 9.1 0.0 0.26 8.7 0.0 1.0 1 0 0 1 1 1 0 Cell morphogenesis central region HTH_Tnp_Tc3_2 PF01498.13 KII71690.1 - 0.054 13.5 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Transposase Trp_repressor PF01371.14 KII71690.1 - 0.15 11.9 0.2 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein SNAP PF14938.1 KII71691.1 - 9.8e-07 28.1 0.0 1.3e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP BCNT PF07572.7 KII71691.1 - 0.057 13.3 0.3 1.9 8.4 0.1 2.4 3 0 0 3 3 3 0 Bucentaur or craniofacial development CBM_21 PF03370.8 KII71691.1 - 0.093 12.7 0.2 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Putative phosphatase regulatory subunit SNAP PF14938.1 KII71692.1 - 7.1e-07 28.6 0.0 9.8e-07 28.1 0.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TRI5 PF06330.6 KII71692.1 - 0.024 13.3 0.3 0.024 13.3 0.2 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) BCNT PF07572.7 KII71692.1 - 0.069 13.0 0.1 2.4 8.1 0.1 2.3 2 0 0 2 2 2 0 Bucentaur or craniofacial development CBM_21 PF03370.8 KII71692.1 - 0.094 12.6 0.2 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Putative phosphatase regulatory subunit DivIC PF04977.10 KII71694.1 - 0.0013 18.1 8.6 0.042 13.3 2.0 2.3 2 0 0 2 2 2 2 Septum formation initiator DEDD_Tnp_IS110 PF01548.12 KII71694.1 - 0.011 15.4 0.4 0.015 14.9 0.3 1.2 1 0 0 1 1 1 0 Transposase CENP-F_leu_zip PF10473.4 KII71694.1 - 0.012 15.4 6.8 0.012 15.4 4.7 2.1 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HAUS-augmin3 PF14932.1 KII71694.1 - 0.022 13.9 7.3 0.02 14.1 4.6 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 TMF_DNA_bd PF12329.3 KII71694.1 - 0.034 13.9 5.0 0.034 13.9 3.5 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Prefoldin PF02996.12 KII71694.1 - 0.041 13.5 8.4 0.054 13.1 2.2 2.2 2 0 0 2 2 2 0 Prefoldin subunit Glyco_hydro_65N PF03636.10 KII71694.1 - 0.044 13.0 0.7 0.053 12.8 0.5 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF349 PF03993.7 KII71694.1 - 0.055 13.6 1.4 0.1 12.7 1.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Prefoldin_2 PF01920.15 KII71694.1 - 0.056 13.2 11.3 0.11 12.3 3.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF972 PF06156.8 KII71694.1 - 0.056 13.7 9.0 0.94 9.8 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) HALZ PF02183.13 KII71694.1 - 0.069 12.8 6.3 5.1 6.8 0.0 2.7 2 1 1 3 3 3 0 Homeobox associated leucine zipper Phage_hub_GP28 PF11110.3 KII71694.1 - 0.12 12.0 0.7 0.17 11.5 0.5 1.2 1 0 0 1 1 1 0 Baseplate hub distal subunit Lysozyme_like PF13702.1 KII71694.1 - 0.18 11.2 1.8 1.5 8.2 0.1 2.1 1 1 0 2 2 2 0 Lysozyme-like DUF1664 PF07889.7 KII71694.1 - 0.43 10.3 5.4 3.7 7.3 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.3 KII71694.1 - 0.53 10.0 9.2 0.19 11.4 2.4 2.2 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding bZIP_1 PF00170.16 KII71694.1 - 0.62 10.0 11.9 0.82 9.6 4.3 2.4 2 0 0 2 2 2 0 bZIP transcription factor FadA PF09403.5 KII71694.1 - 0.66 9.9 6.4 0.51 10.3 1.3 2.1 2 0 0 2 2 2 0 Adhesion protein FadA DUF916 PF06030.7 KII71694.1 - 0.79 9.5 4.5 0.66 9.7 2.1 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF916) Seryl_tRNA_N PF02403.17 KII71694.1 - 0.9 9.5 7.5 0.28 11.2 0.7 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4200 PF13863.1 KII71694.1 - 1.1 9.2 14.7 1.9 8.4 5.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Spc24 PF08286.6 KII71694.1 - 1.1 9.0 12.0 0.26 10.9 2.1 2.3 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 FlxA PF14282.1 KII71694.1 - 1.2 9.1 13.8 1.2 9.1 3.2 2.3 2 0 0 2 2 2 0 FlxA-like protein DUF342 PF03961.8 KII71694.1 - 1.7 6.9 10.2 3.1 6.1 7.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) ATG16 PF08614.6 KII71694.1 - 1.8 8.3 14.7 0.14 11.9 4.5 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Blo-t-5 PF11642.3 KII71694.1 - 1.8 8.3 6.6 7.8 6.2 0.6 2.2 1 1 1 2 2 2 0 Mite allergen Blo t 5 BLOC1_2 PF10046.4 KII71694.1 - 2.6 8.2 10.6 1.8 8.7 2.3 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Rho_Binding PF08912.6 KII71694.1 - 2.6 8.3 10.4 8.3 6.7 3.3 3.0 2 1 0 2 2 2 0 Rho Binding FliD_C PF07195.7 KII71694.1 - 2.8 7.1 11.9 2.5 7.3 2.9 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Takusan PF04822.8 KII71694.1 - 2.8 7.7 14.2 0.43 10.3 2.4 2.7 1 1 0 2 2 2 0 Takusan Cortex-I_coil PF09304.5 KII71694.1 - 3.2 7.8 12.9 1.6 8.8 3.7 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil TPR_MLP1_2 PF07926.7 KII71694.1 - 3.8 7.2 16.4 27 4.5 1.9 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein IncA PF04156.9 KII71694.1 - 4.6 6.7 12.4 1.2 8.7 4.1 2.0 1 1 0 2 2 2 0 IncA protein ERM PF00769.14 KII71694.1 - 6.9 6.1 16.1 7.3 6.0 0.7 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF724 PF05266.9 KII71694.1 - 9.2 5.8 10.2 32 4.0 7.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Wbp11 PF09429.5 KII71694.1 - 9.8 6.2 11.0 1.6 8.7 3.3 2.3 1 1 0 2 2 2 0 WW domain binding protein 11 SSV1_ORF_D-335 PF07935.6 KII71695.1 - 0.099 12.3 0.5 0.2 11.4 0.4 1.5 1 0 0 1 1 1 0 ORF D-335-like protein TPR_11 PF13414.1 KII71696.1 - 0.038 13.6 5.0 0.15 11.7 0.9 2.4 1 1 0 2 2 2 0 TPR repeat TPR_2 PF07719.12 KII71696.1 - 0.1 12.5 1.6 31 4.8 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII71696.1 - 0.24 11.2 3.7 4.9 7.1 0.3 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat NSF PF02071.15 KII71696.1 - 0.98 10.2 7.0 1.6 9.6 0.9 3.0 2 0 0 2 2 2 0 Aromatic-di-Alanine (AdAR) repeat DUF2899 PF11449.3 KII71697.1 - 0.045 12.9 2.0 0.049 12.8 1.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2899) Nop14 PF04147.7 KII71697.1 - 0.36 8.6 1.6 0.39 8.5 1.1 1.0 1 0 0 1 1 1 0 Nop14-like family zf-RING_5 PF14634.1 KII71698.1 - 0.44 10.3 4.0 4.6 7.0 0.4 2.4 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KII71698.1 - 5.9 6.6 7.5 3 7.6 0.2 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cuticle_3 PF11018.3 KII71700.1 - 1.8e-10 41.2 10.5 13 5.8 0.0 7.1 7 0 0 7 7 7 7 Pupal cuticle protein C1 Toxin_65 PF15543.1 KII71700.1 - 4.6e-05 23.0 0.0 2.1e+02 1.5 0.0 6.8 7 0 0 7 7 7 0 Putative toxin 65 DUF2415 PF10313.4 KII71700.1 - 0.00012 21.6 0.0 3.5e+02 0.9 0.0 7.2 8 0 0 8 8 8 0 Uncharacterised protein domain (DUF2415) Uds1 PF15456.1 KII71701.1 - 0.00058 19.8 5.1 0.00083 19.3 3.5 1.2 1 0 0 1 1 1 1 Up-regulated During Septation RPW8 PF05659.6 KII71701.1 - 0.0017 17.9 0.5 0.0017 17.9 0.3 2.1 1 1 1 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF848 PF05852.6 KII71701.1 - 0.0026 17.6 7.7 0.14 11.9 1.1 2.1 2 0 0 2 2 2 2 Gammaherpesvirus protein of unknown function (DUF848) GAS PF13851.1 KII71701.1 - 0.011 14.8 9.6 0.014 14.5 6.6 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding APG17 PF04108.7 KII71701.1 - 0.016 14.0 4.6 0.22 10.2 0.3 2.0 2 0 0 2 2 2 0 Autophagy protein Apg17 IncA PF04156.9 KII71701.1 - 0.016 14.8 5.9 0.021 14.4 4.1 1.2 1 0 0 1 1 1 0 IncA protein Serine_rich PF08824.5 KII71701.1 - 0.018 14.7 0.7 0.023 14.3 0.5 1.2 1 0 0 1 1 1 0 Serine rich protein interaction domain Snapin_Pallidin PF14712.1 KII71701.1 - 0.022 15.0 5.1 0.1 12.9 0.9 2.3 2 0 0 2 2 2 0 Snapin/Pallidin UTP15_C PF09384.5 KII71701.1 - 0.04 13.6 1.3 0.9 9.2 0.1 2.1 2 0 0 2 2 2 0 UTP15 C terminal CDC24 PF06395.6 KII71701.1 - 0.042 13.8 0.1 0.082 12.9 0.1 1.4 1 0 0 1 1 1 0 CDC24 Calponin DUF948 PF06103.6 KII71701.1 - 0.045 13.6 5.6 0.23 11.3 1.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CENP-Q PF13094.1 KII71701.1 - 0.06 13.3 8.2 0.98 9.4 1.7 2.1 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit COG2 PF06148.6 KII71701.1 - 0.065 13.0 4.8 0.19 11.5 0.7 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Lipoprotein_7 PF01540.11 KII71701.1 - 0.066 12.2 8.7 0.16 10.9 0.5 2.0 2 0 0 2 2 2 0 Adhesin lipoprotein DUF2458 PF10454.4 KII71701.1 - 0.069 13.0 10.9 0.51 10.2 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2458) DUF4140 PF13600.1 KII71701.1 - 0.095 13.1 1.8 0.22 11.9 0.2 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Mod_r PF07200.8 KII71701.1 - 0.11 12.4 8.7 0.25 11.2 1.9 2.1 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2433 PF10360.4 KII71701.1 - 0.13 12.5 1.3 0.17 12.2 0.2 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF2433) DUF3847 PF12958.2 KII71701.1 - 0.16 11.7 9.5 0.41 10.4 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) DegS PF05384.6 KII71701.1 - 0.18 11.0 10.3 0.28 10.4 1.9 2.2 1 1 1 2 2 2 0 Sensor protein DegS NuA4 PF09340.5 KII71701.1 - 0.2 11.3 7.8 0.28 10.8 1.3 2.7 1 1 1 2 2 2 0 Histone acetyltransferase subunit NuA4 DUF1993 PF09351.5 KII71701.1 - 0.3 10.9 2.1 5.9 6.7 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) CENP-H PF05837.7 KII71701.1 - 0.3 11.2 12.0 0.97 9.6 3.0 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Tropomyosin_1 PF12718.2 KII71701.1 - 0.32 10.8 8.8 1.6 8.5 0.4 2.2 2 0 0 2 2 2 0 Tropomyosin like NTR2 PF15458.1 KII71701.1 - 0.33 10.1 7.8 0.59 9.3 0.4 2.1 2 0 0 2 2 2 0 Nineteen complex-related protein 2 NPV_P10 PF05531.7 KII71701.1 - 0.44 10.8 6.1 0.88 9.8 1.0 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Corona_S2 PF01601.11 KII71701.1 - 0.53 8.3 8.8 1.6 6.6 1.4 2.0 1 1 1 2 2 2 0 Coronavirus S2 glycoprotein DUF4504 PF14953.1 KII71701.1 - 0.53 9.5 5.8 0.35 10.1 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4504) APG6 PF04111.7 KII71701.1 - 0.76 8.7 8.5 0.91 8.5 1.0 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 Spc7 PF08317.6 KII71701.1 - 0.87 8.1 14.4 3.6 6.1 9.6 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Calici_MSP PF05752.6 KII71701.1 - 1.1 8.8 3.4 0.46 10.0 0.2 1.8 2 0 0 2 2 2 0 Calicivirus minor structural protein TMF_DNA_bd PF12329.3 KII71701.1 - 1.4 8.7 14.8 0.7 9.7 3.3 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding CorA PF01544.13 KII71701.1 - 1.8 7.5 5.6 14 4.5 3.8 1.9 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Laminin_II PF06009.7 KII71701.1 - 3.2 7.5 8.9 25 4.6 6.2 2.1 1 1 0 1 1 1 0 Laminin Domain II Med9 PF07544.8 KII71701.1 - 3.6 7.3 9.2 0.25 11.1 2.0 2.2 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 IATP PF04568.7 KII71701.1 - 3.7 7.6 10.7 3.6 7.6 1.4 2.5 2 1 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP DUF1664 PF07889.7 KII71701.1 - 4.2 7.1 10.0 3.4 7.4 1.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF342 PF03961.8 KII71701.1 - 4.3 5.6 13.1 0.55 8.5 1.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF342) 5_3_exonuc PF01367.15 KII71701.1 - 4.7 7.5 6.8 2.4 8.4 0.4 2.3 2 1 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold Nup54 PF13874.1 KII71701.1 - 6.2 6.4 11.5 2.9 7.5 3.4 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Prefoldin_2 PF01920.15 KII71701.1 - 7.2 6.4 14.2 34 4.2 5.1 2.9 1 1 1 2 2 2 0 Prefoldin subunit TMPIT PF07851.8 KII71701.1 - 7.9 5.4 10.6 3.1 6.7 1.6 2.1 1 1 0 2 2 2 0 TMPIT-like protein FlaC_arch PF05377.6 KII71701.1 - 9.4 6.2 9.2 2.8 7.8 0.5 2.9 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Nucleoporin_N PF08801.6 KII71702.1 - 0.021 13.6 0.3 0.04 12.6 0.2 1.5 1 1 0 1 1 1 0 Nup133 N terminal like gag-asp_proteas PF13975.1 KII71702.1 - 0.052 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease NQRA_SLBB PF11973.3 KII71703.1 - 0.13 12.6 0.1 15 6.0 0.0 2.7 3 0 0 3 3 3 0 NQRA C-terminal domain Spore_YunB PF09560.5 KII71704.1 - 0.051 13.2 0.8 0.087 12.5 0.5 1.5 1 1 0 1 1 1 0 Sporulation protein YunB (Spo_YunB) Laminin_II PF06009.7 KII71705.1 - 0.0093 15.7 0.5 0.29 10.8 0.1 2.1 2 0 0 2 2 2 1 Laminin Domain II TACC PF05010.9 KII71705.1 - 0.071 12.8 2.6 0.66 9.6 1.8 2.0 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) Tropomyosin_1 PF12718.2 KII71705.1 - 0.13 12.1 3.8 3.1 7.6 0.1 2.1 2 0 0 2 2 2 0 Tropomyosin like TMF_TATA_bd PF12325.3 KII71705.1 - 0.14 11.9 2.1 0.22 11.2 0.2 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding FlaC_arch PF05377.6 KII71705.1 - 0.53 10.2 3.5 5 7.1 0.9 2.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF4200 PF13863.1 KII71705.1 - 1.9 8.4 10.1 0.41 10.5 1.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) ATG16 PF08614.6 KII71706.1 - 0.0065 16.3 2.8 0.0068 16.2 0.3 1.9 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) CRISPR_Cse2 PF09485.5 KII71706.1 - 0.027 14.5 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) DUF1664 PF07889.7 KII71706.1 - 0.32 10.7 3.3 0.39 10.5 1.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) V-SNARE PF05008.10 KII71706.1 - 0.55 10.4 4.9 0.35 11.0 0.8 2.2 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Ly49 PF08391.5 KII71706.1 - 1.1 9.4 7.2 4.8 7.3 0.1 2.4 2 1 1 3 3 3 0 Ly49-like protein, N-terminal region Prefoldin_2 PF01920.15 KII71706.1 - 1.9 8.2 8.3 11 5.7 0.1 2.6 2 1 0 2 2 2 0 Prefoldin subunit DUF4200 PF13863.1 KII71706.1 - 3.9 7.4 8.7 1.8 8.5 0.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF2042 PF09743.4 KII71707.1 - 9.8e-50 169.3 0.1 9.8e-50 169.3 0.1 2.7 1 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2042) RCSD PF05177.7 KII71708.1 - 0.012 16.0 0.4 0.015 15.7 0.3 1.1 1 0 0 1 1 1 0 RCSD region DUF3746 PF12562.3 KII71709.1 - 0.12 12.2 1.9 0.23 11.3 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) DUF3724 PF12521.3 KII71709.1 - 0.33 10.7 3.2 0.64 9.8 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3724) UL73_N PF12522.3 KII71709.1 - 0.57 9.7 3.7 1 8.9 2.6 1.3 1 0 0 1 1 1 0 Cytomegalovirus glycoprotein N terminal Metallophos PF00149.23 KII71710.1 - 2.8e-08 33.4 5.3 3.6e-08 33.0 3.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KII71710.1 - 0.0035 17.1 0.1 0.0052 16.6 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KII71711.1 - 3.2e-07 29.9 7.7 4.3e-07 29.5 5.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MTS PF05175.9 KII71712.1 - 9.4e-15 54.4 0.0 1.3e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 KII71712.1 - 3.5e-10 39.9 0.0 4.7e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KII71712.1 - 4.6e-09 35.8 0.1 8.5e-09 34.9 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.1 KII71712.1 - 5e-08 32.6 0.1 7e-08 32.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KII71712.1 - 2.2e-06 27.9 0.0 4.3e-06 27.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 KII71712.1 - 3.6e-06 26.6 0.0 4.6e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.10 KII71712.1 - 3.1e-05 23.4 0.0 4e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.2 KII71712.1 - 6.4e-05 23.4 0.0 0.0001 22.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII71712.1 - 8.5e-05 22.9 0.0 0.00015 22.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.11 KII71712.1 - 0.0034 16.5 0.0 0.0076 15.3 0.0 1.6 1 1 0 1 1 1 1 N-6 DNA Methylase Pfg27 PF09216.5 KII71712.1 - 0.053 13.1 1.2 0.093 12.3 0.8 1.4 1 0 0 1 1 1 0 Pfg27 Methyltransf_12 PF08242.7 KII71712.1 - 0.054 13.9 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF43 PF01861.11 KII71712.1 - 0.07 12.0 0.7 0.13 11.1 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF43 Methyltransf_16 PF10294.4 KII71712.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase HTH_32 PF13565.1 KII71713.1 - 0.00012 22.8 0.0 0.006 17.3 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 KII71713.1 - 0.004 17.2 0.0 0.0073 16.4 0.0 1.5 1 1 0 1 1 1 1 Winged helix-turn helix HTH_40 PF14493.1 KII71713.1 - 0.013 15.7 0.3 0.019 15.1 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.1 KII71713.1 - 0.015 14.9 0.0 0.09 12.4 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain HTH_17 PF12728.2 KII71713.1 - 0.044 14.0 0.0 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain DUF1323 PF07037.6 KII71713.1 - 0.055 13.6 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) Ground-like PF04155.13 KII71713.1 - 0.061 13.6 0.2 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Ground-like domain CENP-B_N PF04218.8 KII71713.1 - 0.063 12.7 0.2 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain TrmB PF01978.14 KII71713.1 - 0.11 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB RVT_1 PF00078.22 KII71716.1 - 0.0015 17.9 0.0 0.0027 17.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WH1 PF00568.18 KII71719.1 - 1.9e-07 30.7 0.3 3e-07 30.1 0.2 1.4 1 1 0 1 1 1 1 WH1 domain Ldl_recept_a PF00057.13 KII71722.1 - 1.1e-10 41.1 26.1 2.3e-06 27.3 5.8 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A RuBisCO_large_N PF02788.11 KII71724.1 - 0.023 14.3 0.1 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain Kelch_6 PF13964.1 KII71725.1 - 0.017 15.2 0.0 3.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Kelch motif C1q PF00386.16 KII71725.1 - 0.025 14.5 0.4 5.7 6.9 0.0 2.2 1 1 1 2 2 2 0 C1q domain Kelch_3 PF13415.1 KII71725.1 - 0.03 14.5 0.0 9.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain ThiF PF00899.16 KII71726.1 - 8.1e-19 67.7 1.1 1.8e-18 66.6 0.7 1.6 1 1 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 KII71726.1 - 0.014 15.4 0.2 0.018 15.1 0.2 1.4 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 KII71726.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain RRM_1 PF00076.17 KII71727.1 - 4.7e-36 122.2 0.0 3.7e-18 64.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII71727.1 - 6.9e-24 83.6 0.0 5.2e-11 42.3 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII71727.1 - 9.9e-21 73.3 0.1 2.4e-09 36.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cas_Cas2CT1978 PF09707.5 KII71727.1 - 0.089 12.7 0.0 14 5.6 0.0 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) DUF605 PF04652.11 KII71727.1 - 1.3 8.2 16.4 1.5 8.1 11.4 1.1 1 0 0 1 1 1 0 Vta1 like Mpp10 PF04006.7 KII71728.1 - 0.0039 15.6 0.4 0.0044 15.4 0.3 1.0 1 0 0 1 1 1 1 Mpp10 protein V-set_CD47 PF08204.6 KII71728.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Toxin-JAB1 PF15659.1 KII71729.1 - 0.1 12.5 0.1 0.12 12.3 0.1 1.1 1 0 0 1 1 1 0 JAB-like toxin 1 rve PF00665.21 KII71730.1 - 4.7e-29 100.9 0.0 1.4e-28 99.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII71730.1 - 9.5e-21 74.1 0.1 2.2e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII71730.1 - 3.9e-08 33.1 0.0 1.2e-07 31.5 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.5 KII71730.1 - 3.6e-06 26.2 1.2 9.7e-06 24.9 0.8 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger zf-CCHC PF00098.18 KII71730.1 - 0.0001 22.0 11.8 0.0055 16.5 1.9 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII71730.1 - 0.00053 20.4 0.0 0.0015 19.0 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII71730.1 - 0.0014 18.2 0.1 0.0037 16.8 0.1 1.7 1 1 0 1 1 1 1 Aspartyl protease rve_3 PF13683.1 KII71730.1 - 0.0026 17.2 0.0 0.0088 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_3 PF13917.1 KII71730.1 - 0.01 15.5 5.6 0.033 13.9 0.3 2.5 1 1 1 2 2 2 1 Zinc knuckle Herpes_UL14 PF03580.9 KII71730.1 - 0.053 13.3 0.1 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL14-like protein gag-asp_proteas PF13975.1 KII71730.1 - 0.06 13.1 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII71730.1 - 0.086 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-ribbon_3 PF13248.1 KII71730.1 - 0.18 11.0 4.0 0.4 9.9 2.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-CCHC_4 PF14392.1 KII71730.1 - 7 6.3 12.1 0.35 10.5 0.6 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_5 PF14787.1 KII71730.1 - 8.1 6.0 14.0 0.36 10.3 0.7 3.2 2 1 1 3 3 3 0 GAG-polyprotein viral zinc-finger DDE_3 PF13358.1 KII71731.1 - 1.1e-12 47.9 0.0 1.1e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII71731.1 - 0.01 14.9 0.0 0.012 14.7 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Galactosyl_T PF01762.16 KII71732.1 - 5.9e-31 107.5 0.9 8.2e-31 107.1 0.6 1.2 1 0 0 1 1 1 1 Galactosyltransferase Clat_adaptor_s PF01217.15 KII71733.1 - 1.5e-24 86.2 4.6 1.8e-24 86.0 3.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain COG6 PF06419.6 KII71734.1 - 2.4e-10 39.2 12.8 3.4e-10 38.7 8.9 1.1 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 BMFP PF04380.8 KII71734.1 - 0.013 15.5 0.4 9.1 6.5 0.0 2.8 2 0 0 2 2 2 0 Membrane fusogenic activity DASH_Dad3 PF08656.5 KII71734.1 - 0.33 10.6 6.2 0.44 10.2 0.2 3.0 2 1 0 2 2 2 0 DASH complex subunit Dad3 YpjP PF14005.1 KII71734.1 - 0.38 10.5 5.0 0.25 11.1 0.2 2.7 3 1 0 3 3 3 0 YpjP-like protein zf-H2C2_2 PF13465.1 KII71736.1 - 4.9e-07 29.7 17.6 0.00013 22.0 0.7 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII71736.1 - 9.9e-07 28.6 14.2 0.037 14.3 1.7 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 KII71736.1 - 3.3e-06 27.1 16.3 0.052 13.9 0.9 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_5 PF13909.1 KII71736.1 - 0.00016 21.7 12.9 0.0014 18.7 0.1 3.6 3 0 0 3 3 3 2 C2H2-type zinc-finger domain Rad9_Rad53_bind PF08605.5 KII71741.1 - 0.053 13.3 0.0 0.12 12.2 0.0 1.5 1 1 0 1 1 1 0 Fungal Rad9-like Rad53-binding Scramblase PF03803.10 KII71742.1 - 0.13 11.3 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Scramblase MRP-L47 PF06984.8 KII71743.1 - 3e-09 36.6 0.2 3.6e-09 36.3 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) rve PF00665.21 KII71744.1 - 4.6e-26 91.2 0.1 2.1e-25 89.1 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII71744.1 - 8.1e-06 25.2 0.2 0.00012 21.5 0.0 2.7 2 0 0 2 2 2 1 Integrase core domain RVP PF00077.15 KII71744.1 - 1.2e-05 25.0 0.0 2.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII71744.1 - 7.2e-05 23.2 0.0 0.00043 20.7 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KII71744.1 - 7.9e-05 22.3 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII71744.1 - 0.0039 16.7 0.0 0.0081 15.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease DUF4070 PF13282.1 KII71744.1 - 0.018 14.5 0.0 0.47 9.9 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4070) RVP_2 PF08284.6 KII71744.1 - 0.11 12.4 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII71744.1 - 0.91 9.3 10.0 2.9 7.7 0.9 2.6 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII71744.1 - 1.5 8.5 8.4 5.8 6.6 0.5 2.7 2 0 0 2 2 2 0 Zinc knuckle SNARE PF05739.14 KII71745.1 - 9.2e-08 31.6 0.5 2.2e-07 30.4 0.2 1.7 2 0 0 2 2 2 1 SNARE domain Peptidase_S64 PF08192.6 KII71745.1 - 0.028 12.7 1.3 0.032 12.5 0.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 Vac_Fusion PF02346.11 KII71745.1 - 0.046 13.1 1.7 7.9 5.9 0.2 2.7 3 0 0 3 3 3 0 Chordopoxvirus fusion protein Enkurin PF13864.1 KII71745.1 - 0.63 10.2 3.4 1.4 9.1 0.9 2.2 2 1 0 2 2 2 0 Calmodulin-binding DUF2477 PF10631.4 KII71746.1 - 0.0088 16.2 0.1 0.012 15.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2477) zf-Sec23_Sec24 PF04810.10 KII71746.1 - 1.1 8.8 6.1 2 8.0 4.3 1.5 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger VWA PF00092.23 KII71747.1 - 2.7e-11 43.5 0.0 3e-11 43.3 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain MAM33 PF02330.11 KII71748.1 - 9.4e-07 28.7 0.3 0.0014 18.4 0.2 2.2 2 0 0 2 2 2 2 Mitochondrial glycoprotein ARPC4 PF05856.7 KII71748.1 - 0.11 11.9 0.3 0.47 9.8 0.2 2.0 2 0 0 2 2 2 0 ARP2/3 complex 20 kDa subunit (ARPC4) DUF914 PF06027.7 KII71749.1 - 0.041 12.7 6.9 0.065 12.0 4.8 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF914) UBN_AB PF14075.1 KII71750.1 - 0.095 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Ubinuclein conserved middle domain E1_DerP2_DerF2 PF02221.10 KII71751.1 - 4.7e-15 56.0 0.5 5.6e-15 55.7 0.4 1.1 1 0 0 1 1 1 1 ML domain ATP12 PF07542.6 KII71752.1 - 5.3e-31 107.1 0.1 6.7e-31 106.7 0.0 1.1 1 0 0 1 1 1 1 ATP12 chaperone protein DUF2405 PF10293.4 KII71752.1 - 0.049 13.3 1.3 4.4 7.0 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2405) DUF2387 PF09526.5 KII71755.1 - 0.054 13.4 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) UPF0547 PF10571.4 KII71758.1 - 0.11 12.1 0.4 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-C2H2 PF00096.21 KII71761.1 - 0.0027 17.9 14.4 0.52 10.7 2.9 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII71761.1 - 0.014 15.6 16.7 0.36 11.2 2.3 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_5 PF13909.1 KII71761.1 - 0.086 13.1 0.2 0.086 13.1 0.1 3.8 2 1 2 4 4 4 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.1 KII71761.1 - 0.4 11.0 19.6 0.52 10.6 1.3 4.0 4 0 0 4 4 4 0 Zinc-finger double domain zf-TRAF PF02176.13 KII71761.1 - 0.64 10.4 14.2 0.21 11.9 5.6 2.4 2 1 1 3 3 3 0 TRAF-type zinc finger DUF35_N PF12172.3 KII71761.1 - 0.67 9.9 4.9 0.36 10.8 1.1 2.3 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-H2C2_5 PF13909.1 KII71762.1 - 0.0014 18.7 0.1 0.0014 18.7 0.1 2.8 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.1 KII71762.1 - 0.0017 18.5 20.3 0.002 18.3 1.8 3.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII71762.1 - 0.0037 17.5 12.1 0.0048 17.1 1.2 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 KII71762.1 - 4 7.9 13.7 0.33 11.3 0.9 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type UPF0093 PF03653.8 KII71763.1 - 0.0076 16.2 0.2 0.0098 15.8 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0093) PEN-2 PF10251.4 KII71764.1 - 0.039 14.1 0.1 0.13 12.5 0.1 1.9 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase Srg PF02118.16 KII71765.1 - 0.021 14.2 1.0 0.024 14.0 0.7 1.2 1 0 0 1 1 1 0 Srg family chemoreceptor Sigma_reg_N PF13800.1 KII71765.1 - 0.034 14.1 0.3 0.066 13.2 0.2 1.4 1 0 0 1 1 1 0 Sigma factor regulator N-terminal COX4_pro_2 PF07835.7 KII71766.1 - 0.22 11.5 1.8 0.68 9.9 1.3 1.9 1 0 0 1 1 1 0 Bacterial aa3 type cytochrome c oxidase subunit IV UN_NPL4 PF11543.3 KII71766.1 - 0.41 10.9 2.8 2 8.7 0.2 2.8 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 DUF2650 PF10853.3 KII71766.1 - 3.8 7.0 5.3 8.2 5.9 3.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2650) YGGT PF02325.12 KII71767.1 - 0.073 13.0 0.2 0.85 9.6 0.0 2.2 2 0 0 2 2 2 0 YGGT family BNR PF02012.15 KII71768.1 - 1.8e-06 26.9 6.0 1.1 9.3 0.1 3.9 3 0 0 3 3 3 3 BNR/Asp-box repeat MFS_1 PF07690.11 KII71769.1 - 7.6e-11 41.3 8.4 8.2e-11 41.2 5.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KII71769.1 - 5.8e-06 25.1 4.6 6e-06 25.0 3.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter ATG22 PF11700.3 KII71769.1 - 0.011 14.2 5.5 0.012 14.0 3.8 1.0 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like DUF3816 PF12822.2 KII71769.1 - 2.5 7.9 13.1 6.7 6.5 8.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) DDE_Tnp_IS1595 PF12762.2 KII71771.1 - 4.6e-09 36.2 0.0 6.8e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Ta0938 PF11494.3 KII71771.1 - 0.027 14.5 0.1 0.058 13.5 0.1 1.6 1 0 0 1 1 1 0 Ta0938 Ribosomal_S8e PF01201.17 KII71772.1 - 4.2e-08 33.4 12.8 2e-06 28.0 8.9 2.1 1 1 0 1 1 1 1 Ribosomal protein S8e Cwf_Cwc_15 PF04889.7 KII71773.1 - 2.4e-61 207.5 19.6 7.8e-41 140.3 7.6 2.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein Bromo_MP PF01573.11 KII71773.1 - 0.65 8.9 4.1 0.94 8.4 2.7 1.4 1 1 0 1 1 1 0 Bromovirus movement protein DUF4407 PF14362.1 KII71773.1 - 1.3 7.9 7.2 1.6 7.5 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RPA_interact_M PF14767.1 KII71773.1 - 1.9 9.2 14.9 0.77 10.5 4.8 2.2 1 1 1 2 2 2 0 Replication protein A interacting middle DDHD PF02862.12 KII71773.1 - 4.2 7.1 6.1 5.6 6.7 4.2 1.1 1 0 0 1 1 1 0 DDHD domain IncA PF04156.9 KII71773.1 - 4.4 6.8 12.9 5.9 6.4 9.0 1.1 1 0 0 1 1 1 0 IncA protein MFS_1 PF07690.11 KII71774.1 - 0.00049 18.9 0.1 0.00058 18.6 0.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4040 PF13244.1 KII71774.1 - 0.047 13.6 0.6 0.091 12.7 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) FUSC-like PF12805.2 KII71775.1 - 0.0015 17.4 0.9 0.0015 17.4 0.6 1.9 2 0 0 2 2 2 1 FUSC-like inner membrane protein yccS DUF3366 PF11846.3 KII71775.1 - 0.03 14.1 1.7 0.036 13.9 1.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3366) DUF4396 PF14342.1 KII71775.1 - 0.32 11.0 6.6 0.39 10.8 3.9 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4396) DUF1282 PF06930.7 KII71775.1 - 0.57 9.8 8.9 1.1 8.9 6.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) PMP22_Claudin PF00822.15 KII71775.1 - 0.8 9.3 5.4 0.9 9.1 3.7 1.0 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family ABC2_membrane_6 PF06182.6 KII71775.1 - 0.87 9.0 9.6 1 8.8 6.7 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein B12D PF06522.6 KII71775.1 - 0.97 9.1 7.8 0.14 11.8 1.7 2.1 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit BPD_transp_2 PF02653.11 KII71775.1 - 1.1 8.2 13.5 2.3 7.1 8.4 1.8 1 1 0 1 1 1 0 Branched-chain amino acid transport system / permease component DUF3094 PF11293.3 KII71775.1 - 2 7.9 4.0 0.61 9.6 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) MMPL PF03176.10 KII71775.1 - 4.3 5.9 7.9 3 6.4 4.8 1.4 1 1 0 1 1 1 0 MMPL family ABC2_membrane PF01061.19 KII71775.1 - 6.2 5.9 13.2 0.15 11.2 3.6 1.8 1 1 1 2 2 2 0 ABC-2 type transporter zf-met2 PF12907.2 KII71778.1 - 0.0086 16.0 0.1 0.019 14.9 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding zf-BED PF02892.10 KII71778.1 - 0.1 12.4 0.3 0.16 11.7 0.2 1.3 1 0 0 1 1 1 0 BED zinc finger SNAP PF14938.1 KII71779.1 - 0.0013 17.9 0.1 0.0015 17.7 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP HTH_38 PF13936.1 KII71782.1 - 0.0005 19.5 0.1 0.035 13.6 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.8 KII71782.1 - 0.00079 18.8 0.0 0.0015 17.9 0.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain LacI PF00356.16 KII71782.1 - 0.00084 18.9 0.0 0.0015 18.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_3 PF01381.17 KII71782.1 - 0.001 18.8 0.2 0.003 17.3 0.1 1.8 2 0 0 2 2 2 1 Helix-turn-helix DUF258 PF03193.11 KII71782.1 - 0.0032 16.6 0.6 0.0038 16.4 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF258 HTH_IclR PF09339.5 KII71782.1 - 0.023 14.2 0.0 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_36 PF13730.1 KII71782.1 - 0.051 13.7 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3837 PF12939.2 KII71782.1 - 0.066 13.2 0.1 0.4 10.7 0.0 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3837) HTH_23 PF13384.1 KII71782.1 - 0.081 12.6 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_psq PF05225.11 KII71782.1 - 0.09 12.3 0.5 0.19 11.3 0.1 1.7 2 0 0 2 2 2 0 helix-turn-helix, Psq domain LEF-9 PF05094.7 KII71783.1 - 0.01 14.2 0.3 0.01 14.2 0.2 1.1 1 0 0 1 1 1 0 Late expression factor 9 (LEF-9) rve PF00665.21 KII71786.1 - 0.016 15.3 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain P2X_receptor PF00864.14 KII71787.1 - 0.0086 14.8 0.2 0.01 14.5 0.1 1.0 1 0 0 1 1 1 1 ATP P2X receptor AAA PF00004.24 KII71789.1 - 1.8e-22 79.9 0.9 4.9e-21 75.3 0.3 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KII71789.1 - 3e-06 27.3 0.4 0.00077 19.4 0.0 2.6 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 KII71789.1 - 7.8e-05 22.8 0.3 0.0035 17.4 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.9 KII71789.1 - 0.00016 21.6 0.9 0.083 12.7 0.1 3.0 3 1 1 4 4 4 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 KII71789.1 - 0.00038 20.2 0.7 0.0052 16.5 0.0 2.9 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 KII71789.1 - 0.00085 19.0 0.2 0.0023 17.6 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 KII71789.1 - 0.0013 17.8 0.0 0.0021 17.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 KII71789.1 - 0.0017 17.5 0.1 0.015 14.4 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KII71789.1 - 0.0022 17.4 0.8 0.026 13.9 0.1 2.3 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.12 KII71789.1 - 0.0023 17.3 0.1 0.0054 16.1 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.11 KII71789.1 - 0.0032 16.7 0.0 0.0057 15.9 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_33 PF13671.1 KII71789.1 - 0.012 15.5 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KII71789.1 - 0.013 16.3 0.0 0.027 15.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 KII71789.1 - 0.019 14.5 0.2 0.04 13.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 KII71789.1 - 0.039 13.5 0.0 0.13 11.7 0.0 1.8 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.1 KII71789.1 - 0.047 13.6 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 KII71789.1 - 0.049 12.7 0.1 0.17 10.9 0.0 1.9 1 1 0 1 1 1 0 KaiC AAA_18 PF13238.1 KII71789.1 - 0.054 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KII71789.1 - 0.057 12.5 0.1 0.099 11.7 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.21 KII71789.1 - 0.067 12.6 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.7 KII71789.1 - 0.084 12.5 0.8 1.5 8.4 0.0 2.7 2 1 1 3 3 3 0 NACHT domain RNA_helicase PF00910.17 KII71789.1 - 0.085 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 KII71789.1 - 0.1 12.4 0.0 0.71 9.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.22 KII71789.1 - 0.1 12.8 0.1 0.63 10.3 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Arch_ATPase PF01637.13 KII71789.1 - 0.11 12.2 0.1 1.8 8.1 0.1 2.3 1 1 0 1 1 1 0 Archaeal ATPase Acetyltransf_1 PF00583.19 KII71790.1 - 3.5e-12 46.1 0.0 4.7e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KII71790.1 - 2e-07 31.0 0.0 3.1e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KII71790.1 - 0.00043 20.3 0.0 0.00065 19.8 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KII71790.1 - 0.0016 18.1 0.0 0.0034 17.0 0.0 1.4 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 KII71790.1 - 0.0078 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Tet_JBP PF12851.2 KII71791.1 - 0.081 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily Med29 PF11568.3 KII71792.1 - 0.014 15.4 0.1 0.019 15.0 0.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 29 HTH_20 PF12840.2 KII71792.1 - 0.054 13.3 0.1 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain CABIT PF12736.2 KII71792.1 - 0.064 12.2 0.1 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Cell-cycle sustaining, positive selection, Rota_VP2 PF05087.7 KII71792.1 - 0.1 10.4 0.0 0.13 10.1 0.0 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein RVT_1 PF00078.22 KII71793.1 - 0.0029 17.0 0.3 0.51 9.6 0.0 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Frag1 PF10277.4 KII71797.1 - 0.053 12.9 0.9 0.083 12.3 0.6 1.4 1 1 0 1 1 1 0 Frag1/DRAM/Sfk1 family E2F_TDP PF02319.15 KII71797.1 - 0.1 12.2 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain DUF3753 PF12575.3 KII71797.1 - 6.8 6.5 11.5 3.3 7.5 0.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3753) RVT_1 PF00078.22 KII71802.1 - 1.2e-27 96.7 0.2 3.4e-27 95.2 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII71802.1 - 5.3e-25 87.8 0.0 1.5e-24 86.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71802.1 - 0.00068 19.1 2.4 0.00078 18.9 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain Spuma_A9PTase PF03539.9 KII71802.1 - 0.007 16.2 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) AAA_8 PF12780.2 KII71803.1 - 0.029 13.3 0.2 0.047 12.6 0.1 1.3 1 1 0 1 1 1 0 P-loop containing dynein motor region D4 RVT_1 PF00078.22 KII71805.1 - 1e-05 25.0 0.1 3.9e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Dehydratase_MU PF02288.10 KII71805.1 - 0.052 13.2 0.0 0.1 12.3 0.0 1.5 1 1 0 1 1 1 0 Dehydratase medium subunit rve PF00665.21 KII71806.1 - 4.5e-05 23.5 0.1 8.5e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII71808.1 - 2.7e-14 53.1 0.0 6.8e-14 51.8 0.0 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease APC_CDC26 PF10471.4 KII71808.1 - 0.12 13.1 0.4 0.19 12.4 0.3 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 IpaB_EvcA PF03278.8 KII71809.1 - 0.032 13.4 0.1 0.097 11.8 0.0 1.6 1 1 0 2 2 2 0 IpaB/EvcA family Anp1 PF03452.9 KII71810.1 - 0.088 11.9 0.1 0.088 11.9 0.1 1.1 1 0 0 1 1 1 0 Anp1 rve PF00665.21 KII71815.1 - 3.6e-27 94.8 0.0 8.2e-27 93.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71815.1 - 0.00024 20.5 0.0 0.00076 18.9 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS1595 PF12762.2 KII71816.1 - 0.0009 19.1 0.3 0.0014 18.4 0.1 1.5 2 0 0 2 2 2 1 ISXO2-like transposase domain zf-C2H2 PF00096.21 KII71816.1 - 6.7 7.2 9.1 2.7 8.4 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type PIF1 PF05970.9 KII71817.1 - 0.00095 18.2 0.1 0.00099 18.1 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase T2SE PF00437.15 KII71817.1 - 0.1 11.5 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein MULE PF10551.4 KII71818.1 - 0.00082 19.4 0.0 0.0025 17.9 0.0 1.8 1 1 0 1 1 1 1 MULE transposase domain Vhr1 PF04001.8 KII71818.1 - 0.059 13.2 0.4 0.14 12.0 0.2 1.6 1 0 0 1 1 1 0 Transcription factor Vhr1 RIH_assoc PF08454.6 KII71818.1 - 0.1 12.2 1.5 0.18 11.4 1.1 1.5 1 1 0 1 1 1 0 RyR and IP3R Homology associated DUF4145 PF13643.1 KII71818.1 - 0.12 12.2 1.4 0.51 10.2 0.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4145) Complex1_LYR_2 PF13233.1 KII71818.1 - 0.27 11.7 2.0 0.37 11.2 1.4 1.2 1 0 0 1 1 1 0 Complex1_LYR-like Baculo_LEF5 PF04838.7 KII71819.1 - 0.068 12.9 0.1 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 DUF4129 PF13559.1 KII71820.1 - 0.027 14.4 0.1 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) rve PF00665.21 KII71821.1 - 3.7e-24 85.1 0.0 8.3e-24 83.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII71821.1 - 0.00026 20.3 0.7 0.0023 17.3 0.0 2.7 3 0 0 3 3 3 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII71821.1 - 0.0073 15.8 0.0 0.029 13.9 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII71821.1 - 0.031 14.2 0.0 0.091 12.7 0.0 1.7 1 0 0 1 1 1 0 DDE domain RVT_1 PF00078.22 KII71822.1 - 0.0017 17.7 0.0 0.0036 16.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.1 KII71822.1 - 0.034 14.6 0.0 0.064 13.7 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII71822.1 - 0.079 12.7 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease cIII PF08134.6 KII71823.1 - 0.016 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 cIII protein family PDT PF00800.13 KII71824.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydratase RVT_1 PF00078.22 KII71825.1 - 0.0011 18.3 0.0 0.0022 17.3 0.0 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-TRAF PF02176.13 KII71826.1 - 2.8 8.3 10.2 5.9 7.3 5.0 2.9 2 2 1 3 3 3 0 TRAF-type zinc finger zf-CCHC_4 PF14392.1 KII71826.1 - 6.6 6.4 8.3 0.85 9.3 0.7 2.7 2 1 0 3 3 3 0 Zinc knuckle RVT_1 PF00078.22 KII71829.1 - 0.0028 17.0 0.1 0.004 16.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) INT_SG_DDX_CT_C PF15300.1 KII71829.1 - 0.1 12.0 0.2 0.19 11.2 0.1 1.5 1 1 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus UPF0150 PF03681.10 KII71829.1 - 0.14 11.7 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0150) rve PF00665.21 KII71831.1 - 0.0011 19.0 0.2 0.0019 18.2 0.0 1.4 2 0 0 2 2 2 1 Integrase core domain GNAT_acetyltr_2 PF13718.1 KII71831.1 - 0.11 11.7 0.7 3.7 6.8 0.0 2.0 1 1 1 2 2 2 0 GNAT acetyltransferase 2 DDE_3 PF13358.1 KII71832.1 - 1.1e-08 34.9 0.0 1.6e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII71832.1 - 0.037 14.0 0.0 0.074 13.1 0.0 1.5 1 0 0 1 1 1 0 Transposase HTH_23 PF13384.1 KII71832.1 - 0.082 12.5 0.1 4.1 7.1 0.0 2.7 2 0 0 2 2 2 0 Homeodomain-like domain RVT_1 PF00078.22 KII71833.1 - 6.3e-05 22.4 0.1 0.0001 21.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.1 KII71834.1 - 0.047 13.5 0.0 0.088 12.6 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DDE_3 PF13358.1 KII71835.1 - 0.00025 20.8 0.0 0.00057 19.6 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2785 PF10978.3 KII71836.1 - 0.021 14.2 0.1 0.24 10.8 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2785) RVT_1 PF00078.22 KII71839.1 - 4.9e-07 29.3 0.1 9.6e-07 28.3 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII71840.1 - 1.1e-18 67.5 0.0 1.6e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71840.1 - 0.00045 19.6 0.0 0.00088 18.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_AsnC-type PF13404.1 KII71841.1 - 0.17 11.4 0.7 0.44 10.1 0.1 1.9 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain DDE_1 PF03184.14 KII71842.1 - 9.8e-05 21.5 0.0 0.00019 20.6 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII71842.1 - 0.026 14.3 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain CENP-B_dimeris PF09026.5 KII71842.1 - 0.23 11.7 2.6 0.34 11.1 1.3 1.7 1 1 0 1 1 1 0 Centromere protein B dimerisation domain rve PF00665.21 KII71847.1 - 7.4e-16 58.3 0.0 1.5e-15 57.3 0.0 1.6 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII71847.1 - 0.00043 19.7 0.0 0.001 18.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII71847.1 - 0.0015 17.8 0.0 0.0031 16.8 0.0 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger DUF2633 PF11119.3 KII71853.1 - 0.042 13.5 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) Rootletin PF15035.1 KII71858.1 - 0.007 16.3 0.0 0.0071 16.3 0.0 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion RVT_1 PF00078.22 KII71861.1 - 5.2e-23 81.5 0.1 4.6e-22 78.4 0.0 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3640 PF12342.3 KII71862.1 - 5.1 6.7 5.4 0.9 9.1 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3640) HTH_16 PF12645.2 KII71865.1 - 0.34 10.8 3.6 2.4 8.1 0.1 2.6 2 1 1 3 3 3 0 Helix-turn-helix domain SNAP PF14938.1 KII71866.1 - 2.3e-14 53.2 4.0 3.8e-14 52.5 2.8 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP rve PF00665.21 KII71868.1 - 1.2e-18 67.3 0.0 2.9e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII71868.1 - 5.8e-10 38.8 0.2 1.2e-09 37.8 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII71869.1 - 7.2e-06 25.8 0.1 1.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII71869.1 - 0.013 15.1 2.1 0.013 15.1 1.4 2.4 1 1 1 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.1 KII71869.1 - 0.015 15.7 0.1 0.041 14.3 0.1 1.7 1 0 0 1 1 1 0 Aspartyl protease YhfH PF14149.1 KII71869.1 - 0.076 12.8 1.7 0.14 11.9 1.2 1.4 1 0 0 1 1 1 0 YhfH-like protein Herpes_gE PF02480.11 KII71870.1 - 0.051 11.8 0.2 0.14 10.4 0.0 1.7 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E DUF4199 PF13858.1 KII71870.1 - 0.056 13.3 0.2 0.63 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Reticulon PF02453.12 KII71870.1 - 0.068 12.7 0.0 5.3 6.6 0.0 2.2 2 0 0 2 2 2 0 Reticulon CD34_antigen PF06365.7 KII71870.1 - 0.15 11.6 0.5 0.33 10.5 0.0 1.7 2 0 0 2 2 2 0 CD34/Podocalyxin family EphA2_TM PF14575.1 KII71870.1 - 0.42 11.0 2.7 1 9.7 1.9 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Phage_connect_1 PF05135.8 KII71872.1 - 0.015 15.4 4.0 0.032 14.3 1.8 2.4 2 0 0 2 2 2 0 Phage gp6-like head-tail connector protein Intg_mem_TP0381 PF09529.5 KII71874.1 - 0.014 14.6 0.2 0.014 14.6 0.1 1.1 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) DDE_3 PF13358.1 KII71875.1 - 2.3e-07 30.6 0.0 3.4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_S9 PF00326.16 KII71879.1 - 1.2e-20 73.6 0.0 9e-13 47.9 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KII71879.1 - 1.3e-12 47.6 0.0 1.7e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KII71879.1 - 1.3e-07 31.7 0.0 0.00036 20.4 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII71879.1 - 2.6e-07 30.4 0.0 0.0001 21.9 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.13 KII71879.1 - 4.2e-07 29.4 0.0 6.1e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.11 KII71879.1 - 6.3e-05 22.5 0.0 0.0001 21.8 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S28 PF05577.7 KII71879.1 - 0.00032 19.4 0.0 0.0014 17.3 0.0 1.8 2 0 0 2 2 2 1 Serine carboxypeptidase S28 FSH1 PF03959.8 KII71879.1 - 0.0027 17.1 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.13 KII71879.1 - 0.023 14.0 0.0 0.53 9.6 0.0 2.1 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Tannase PF07519.6 KII71879.1 - 0.11 11.1 0.1 0.22 10.2 0.0 1.4 2 0 0 2 2 2 0 Tannase and feruloyl esterase SHQ1 PF04925.10 KII71883.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 SHQ1 protein CATSPERD PF15020.1 KII71884.1 - 0.011 13.8 0.1 0.012 13.6 0.1 1.0 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit delta BNIP3 PF06553.7 KII71887.1 - 0.051 12.9 0.4 0.053 12.8 0.3 1.1 1 0 0 1 1 1 0 BNIP3 CRT10 PF08728.5 KII71887.1 - 0.33 8.8 3.5 0.34 8.8 2.4 1.0 1 0 0 1 1 1 0 CRT10 Dimer_Tnp_hAT PF05699.9 KII71888.1 - 0.0003 20.3 0.3 0.00037 20.0 0.2 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Orthoreo_P17 PF07272.6 KII71890.1 - 0.012 15.4 2.1 0.79 9.5 0.4 2.1 2 0 0 2 2 2 0 Orthoreovirus P17 protein Iron_traffic PF04362.9 KII71890.1 - 1.2 8.6 3.3 1.5 8.3 0.4 2.5 2 1 1 3 3 3 0 Bacterial Fe(2+) trafficking DUF1132 PF06575.7 KII71893.1 - 0.12 12.6 1.1 0.19 12.0 0.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1132) DUF1681 PF07933.9 KII71895.1 - 1.8e-12 47.0 0.0 2.5e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Peptidase_C1 PF00112.18 KII71897.1 - 4.3e-13 49.6 0.0 6.8e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII71897.1 - 3e-10 40.1 3.1 5e-10 39.5 2.2 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.18 KII71898.1 - 3.4e-49 167.6 0.0 5.3e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII71898.1 - 7.3e-11 42.1 4.2 1.5e-10 41.1 2.9 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C39_2 PF13529.1 KII71898.1 - 0.01 16.1 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 0 Peptidase_C39 like family DUF694 PF05107.7 KII71898.1 - 0.019 14.2 0.2 0.036 13.2 0.1 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF694) Glyco_transf_10 PF00852.14 KII71899.1 - 2.7e-50 170.9 10.0 3.4e-50 170.5 6.9 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) Glyco_transf_10 PF00852.14 KII71900.1 - 3.8e-48 163.8 7.8 4.9e-48 163.4 5.4 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) Glyco_transf_10 PF00852.14 KII71901.1 - 2.9e-12 45.8 0.4 3.1e-12 45.7 0.2 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) MOZ_SAS PF01853.13 KII71902.1 - 0.022 13.9 0.5 4.1 6.5 0.1 2.1 1 1 1 2 2 2 0 MOZ/SAS family Cir_Bir_Yir PF06022.6 KII71902.1 - 0.086 12.0 2.4 0.066 12.4 0.5 1.6 2 0 0 2 2 2 0 Plasmodium variant antigen protein Cir/Yir/Bir ATP-synt_8 PF00895.15 KII71902.1 - 0.16 12.2 1.3 0.43 10.8 0.9 1.8 1 0 0 1 1 1 0 ATP synthase protein 8 API5 PF05918.6 KII71903.1 - 2.2e-05 23.1 0.0 2.7e-05 22.8 0.0 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) Prok-RING_1 PF14446.1 KII71903.1 - 0.045 13.4 0.2 0.076 12.7 0.1 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Fip1 PF05182.8 KII71904.1 - 1.7e-22 78.4 1.9 2.8e-22 77.7 1.3 1.4 1 0 0 1 1 1 1 Fip1 motif Transformer PF06495.6 KII71904.1 - 0.00091 19.1 13.7 0.0015 18.4 9.5 1.4 1 0 0 1 1 1 1 Fruit fly transformer protein DUF1777 PF08648.7 KII71904.1 - 3.8 7.1 35.2 6.3 6.4 24.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) GST_C PF00043.20 KII71905.1 - 1.3e-05 25.0 0.0 3.1e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KII71905.1 - 0.00014 21.6 0.0 0.00022 21.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KII71905.1 - 0.0019 18.6 0.0 0.0032 17.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain AAR2 PF05282.6 KII71905.1 - 0.045 12.6 0.1 0.063 12.1 0.0 1.2 1 0 0 1 1 1 0 AAR2 protein AA_permease_2 PF13520.1 KII71906.1 - 1e-47 162.6 39.4 1e-47 162.6 27.3 2.7 2 1 0 2 2 2 1 Amino acid permease AA_permease PF00324.16 KII71906.1 - 1.6e-36 125.7 35.8 1.6e-36 125.7 24.8 2.7 2 1 1 3 3 3 2 Amino acid permease AA_permease_C PF13906.1 KII71906.1 - 3.1e-13 49.3 15.1 3.1e-13 49.3 10.5 4.5 4 2 1 5 5 5 1 C-terminus of AA_permease DUF4094 PF13334.1 KII71906.1 - 0.74 10.2 2.5 2.1 8.8 1.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) NAGidase PF07555.8 KII71907.1 - 6.4e-85 284.7 0.0 9.2e-85 284.2 0.0 1.2 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase Laminin_II PF06009.7 KII71910.1 - 0.061 13.0 2.8 0.089 12.5 2.0 1.3 1 0 0 1 1 1 0 Laminin Domain II Homeobox PF00046.24 KII71910.1 - 0.07 12.7 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 Homeobox domain AAA_14 PF13173.1 KII71910.1 - 0.087 12.7 1.0 0.12 12.2 0.6 1.4 1 1 0 1 1 1 0 AAA domain FliJ PF02050.11 KII71910.1 - 0.11 12.5 3.0 0.18 11.8 2.1 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein Sugarporin_N PF11471.3 KII71910.1 - 0.12 11.9 0.1 0.12 11.9 0.1 2.0 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Picorna_P3A PF06363.6 KII71910.1 - 0.15 12.0 2.2 2.1 8.4 0.2 2.4 1 1 1 2 2 2 0 Picornaviridae P3A protein DUF1313 PF07011.6 KII71910.1 - 0.15 11.6 4.3 1.2 8.8 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1313) DUF489 PF04356.7 KII71910.1 - 0.8 9.2 6.5 1.6 8.3 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF489) Enterotoxin_b PF01376.13 KII71913.1 - 0.083 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Heat-labile enterotoxin beta chain HEM4 PF02602.10 KII71914.1 - 5.9e-17 61.6 0.0 6.6e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD TctB PF07331.6 KII71915.1 - 0.051 13.2 2.8 0.07 12.7 2.0 1.3 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF2104 PF09877.4 KII71915.1 - 1.3 8.9 4.6 2 8.4 0.5 2.7 2 1 0 2 2 2 0 Predicted membrane protein (DUF2104) PGG PF13962.1 KII71915.1 - 1.4 8.5 6.5 0.16 11.6 1.7 1.6 2 0 0 2 2 2 0 Domain of unknown function Transgly_assoc PF04226.8 KII71915.1 - 8 6.6 10.8 5 7.2 1.3 2.7 2 1 0 2 2 2 0 Transglycosylase associated protein MA3 PF02847.12 KII71920.1 - 5.2e-05 22.9 0.7 5.2e-05 22.9 0.5 3.2 3 0 0 3 3 3 1 MA3 domain FadA PF09403.5 KII71920.1 - 0.0069 16.3 1.2 0.025 14.6 0.9 2.0 1 0 0 1 1 1 1 Adhesion protein FadA DDE_Tnp_IS1595 PF12762.2 KII71925.1 - 1.3e-07 31.6 0.0 1.7e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_Tnp_IS1595 PF12760.2 KII71925.1 - 0.0043 16.8 2.0 0.0043 16.8 1.4 1.7 2 0 0 2 2 2 1 Transposase zinc-ribbon domain zf-C4_Topoisom PF01396.14 KII71925.1 - 0.03 13.8 3.3 0.059 12.8 2.3 1.5 1 0 0 1 1 1 0 Topoisomerase DNA binding C4 zinc finger Terminase_5 PF06056.7 KII71925.1 - 0.057 12.9 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) OrfB_Zn_ribbon PF07282.6 KII71925.1 - 0.11 12.1 1.4 0.2 11.3 0.9 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain FLYWCH PF04500.11 KII71928.1 - 2.8e-15 55.9 4.2 7.3e-15 54.5 2.9 1.7 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 KII71928.1 - 1.7e-11 44.1 0.0 1.3e-09 38.0 0.0 2.5 2 0 0 2 2 2 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.12 KII71928.1 - 0.066 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Transposase EMA PF02488.10 KII71928.1 - 0.081 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Merozoite Antigen Zn_ribbon_recom PF13408.1 KII71928.1 - 0.38 11.0 6.9 0.82 9.9 4.8 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF603 PF04645.7 KII71929.1 - 0.0037 17.2 6.8 0.038 13.9 1.3 2.0 1 1 1 2 2 2 2 Protein of unknown function, DUF603 FliJ PF02050.11 KII71929.1 - 0.0061 16.6 1.0 0.054 13.5 0.1 2.1 1 1 1 2 2 2 1 Flagellar FliJ protein PRESAN PF09687.5 KII71929.1 - 0.0084 16.1 9.1 0.019 15.0 2.5 2.2 1 1 1 2 2 2 1 Plasmodium RESA N-terminal Cytochrom_B562 PF07361.6 KII71929.1 - 0.031 14.6 0.6 0.5 10.8 0.1 2.2 1 1 1 2 2 2 0 Cytochrome b562 DUF489 PF04356.7 KII71929.1 - 0.035 13.6 0.2 0.041 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) Sds3 PF08598.6 KII71929.1 - 0.45 10.0 5.0 1 8.8 3.5 1.6 1 1 0 1 1 1 0 Sds3-like Proteasome PF00227.21 KII71931.1 - 3.1e-34 117.9 0.0 3.5e-34 117.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Alpha_E3_glycop PF01563.11 KII71931.1 - 0.031 14.0 0.2 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 Alphavirus E3 glycoprotein DUF2607 PF10795.4 KII71933.1 - 0.037 13.8 0.3 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2607) zf-BED PF02892.10 KII71934.1 - 0.015 15.0 0.7 0.034 13.9 0.5 1.6 1 0 0 1 1 1 0 BED zinc finger ATP_bind_3 PF01171.15 KII71936.1 - 1.8e-05 24.3 0.0 2.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.11 KII71936.1 - 0.02 13.4 0.0 0.034 12.6 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase NAD_synthase PF02540.12 KII71936.1 - 0.021 13.7 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 NAD synthase Asn_synthase PF00733.16 KII71936.1 - 0.021 14.3 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Asparagine synthase PADR1 PF08063.7 KII71936.1 - 0.026 13.9 1.2 0.037 13.4 0.9 1.2 1 0 0 1 1 1 0 PADR1 (NUC008) domain PAPS_reduct PF01507.14 KII71936.1 - 0.031 14.1 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family DUF4428 PF14471.1 KII71936.1 - 0.14 11.9 0.5 0.22 11.2 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) DUF4193 PF13834.1 KII71936.1 - 0.27 11.4 1.0 0.45 10.7 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4193) IRF-2BP1_2 PF11261.3 KII71936.1 - 1.3 8.5 4.6 7.3 6.1 3.2 2.0 1 1 0 1 1 1 0 Interferon regulatory factor 2-binding protein zinc finger Use1 PF09753.4 KII71939.1 - 0.086 12.2 4.3 0.13 11.6 2.9 1.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 DUF4337 PF14235.1 KII71939.1 - 1.1 9.1 3.1 2.4 7.9 2.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) IncA PF04156.9 KII71939.1 - 7.6 6.0 9.3 10 5.6 5.8 1.8 1 1 0 1 1 1 0 IncA protein DUF4591 PF15261.1 KII71939.1 - 9.1 6.5 8.7 1.4 9.2 3.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4591) DUF3896 PF13035.1 KII71940.1 - 0.092 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) GTP_EFTU PF00009.22 KII71942.1 - 4.9e-14 52.1 0.0 1.2e-13 50.9 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 KII71942.1 - 7.9e-12 45.2 0.1 4.8e-11 42.6 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 KII71942.1 - 4.7e-09 36.2 0.2 1.4e-08 34.7 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 PduV-EutP PF10662.4 KII71942.1 - 0.078 12.4 0.1 4 6.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DHO_dh PF01180.16 KII71943.1 - 1.7e-46 158.5 0.0 2.3e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 KII71943.1 - 0.00096 18.0 0.0 0.0017 17.2 0.0 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.10 KII71943.1 - 0.0021 17.2 0.0 0.0048 16.1 0.0 1.5 2 0 0 2 2 2 1 Nitronate monooxygenase DeoC PF01791.4 KII71943.1 - 0.046 13.0 0.0 0.096 11.9 0.0 1.4 1 0 0 1 1 1 0 DeoC/LacD family aldolase TetR_N PF00440.18 KII71945.1 - 1.2e-14 53.6 0.1 2.2e-14 52.7 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Oxidored_FMN PF00724.15 KII71946.1 - 1.8e-65 221.2 0.0 3.4e-65 220.2 0.0 1.5 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family adh_short PF00106.20 KII71946.1 - 9.2e-32 110.2 1.1 1.6e-31 109.5 0.8 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KII71946.1 - 5.3e-14 52.2 0.4 9.1e-14 51.5 0.3 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KII71946.1 - 2.1e-09 37.5 0.1 3.7e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 KII71946.1 - 0.00076 18.9 0.1 0.0015 18.0 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 KII71946.1 - 0.009 15.7 0.0 0.11 12.2 0.0 2.4 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 KII71946.1 - 0.046 13.7 0.2 0.099 12.6 0.2 1.6 1 0 0 1 1 1 0 NADH(P)-binding Topo_C_assoc PF14370.1 KII71947.1 - 0.044 13.4 0.1 1.4 8.6 0.1 2.2 2 0 0 2 2 2 0 C-terminal topoisomerase domain EpsG PF14897.1 KII71948.1 - 0.025 13.5 0.1 0.026 13.4 0.1 1.0 1 0 0 1 1 1 0 EpsG family HXXEE PF13787.1 KII71948.1 - 0.093 13.1 0.2 0.13 12.5 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function with HXXEE motif Ribosomal_L28 PF00830.14 KII71949.1 - 0.017 14.9 1.2 0.017 14.9 0.8 2.2 2 0 0 2 2 2 0 Ribosomal L28 family RRM_2 PF04059.7 KII71949.1 - 0.18 11.8 6.4 0.094 12.7 1.0 2.7 2 2 1 3 3 3 0 RNA recognition motif 2 BTP PF05232.7 KII71950.1 - 1.6e-16 59.7 0.7 5.3e-11 42.0 0.0 2.2 2 0 0 2 2 2 2 Bacterial Transmembrane Pair family HHA PF05321.6 KII71950.1 - 6.1e-15 55.0 0.0 8.2e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Haemolysin expression modulating protein ABC_ATPase PF09818.4 KII71951.1 - 0.27 9.7 1.4 0.3 9.6 1.0 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Autotransporter PF03797.14 KII71952.1 - 2.7e-32 112.1 20.1 3.3e-32 111.9 13.9 1.1 1 0 0 1 1 1 1 Autotransporter beta-domain BOF PF04076.8 KII71953.1 - 2.2e-16 59.5 1.8 3e-16 59.1 1.2 1.1 1 0 0 1 1 1 1 Bacterial OB fold (BOF) protein tRNA_anti-codon PF01336.20 KII71953.1 - 0.0029 17.4 1.1 0.0056 16.5 0.6 1.6 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4431 PF14485.1 KII71953.1 - 0.0058 16.2 1.2 0.052 13.1 0.0 2.8 3 1 1 4 4 4 1 Domain of unknown function (DUF4431) tRNA_anti-like PF12869.2 KII71953.1 - 0.079 12.4 0.0 0.26 10.7 0.0 1.8 1 1 0 1 1 1 0 tRNA_anti-like GerE PF00196.14 KII71954.1 - 2.6e-09 36.2 0.0 3.9e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_7 PF02796.10 KII71954.1 - 0.00025 20.8 0.1 0.00053 19.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.1 KII71954.1 - 0.0016 18.0 0.0 0.0033 17.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII71954.1 - 0.0072 16.3 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_40 PF14493.1 KII71954.1 - 0.014 15.6 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Terminase_5 PF06056.7 KII71954.1 - 0.037 13.5 0.0 0.1 12.1 0.0 1.7 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Sigma70_r4_2 PF08281.7 KII71954.1 - 0.059 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_38 PF13936.1 KII71954.1 - 0.083 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_20 PF12840.2 KII71954.1 - 0.17 11.7 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_36 PF13730.1 KII71955.1 - 0.023 14.8 0.1 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.2 KII71955.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 MarR family LNS2 PF08235.8 KII71959.1 - 2e-61 206.1 0.0 3.3e-61 205.4 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 KII71959.1 - 2.8e-27 94.5 0.0 5.4e-27 93.6 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region NTF2 PF02136.15 KII71960.1 - 7e-10 39.3 0.0 7.8e-10 39.1 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.1 KII71960.1 - 0.019 15.1 0.0 0.021 15.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) HTH_Tnp_Tc5 PF03221.11 KII71961.1 - 5.8e-10 38.8 0.1 9.2e-10 38.2 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 KII71961.1 - 0.00019 20.7 0.4 0.00051 19.4 0.3 1.8 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_3 PF01381.17 KII71961.1 - 0.0012 18.6 0.3 0.01 15.6 0.0 2.5 3 0 0 3 3 3 1 Helix-turn-helix HTH_23 PF13384.1 KII71961.1 - 0.0016 18.0 0.2 0.0065 16.0 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain LacI PF00356.16 KII71961.1 - 0.0032 17.0 0.0 0.0056 16.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_psq PF05225.11 KII71961.1 - 0.0046 16.4 0.1 0.01 15.3 0.1 1.6 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_38 PF13936.1 KII71961.1 - 0.0061 16.0 0.1 0.015 14.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain DUF2315 PF10231.4 KII71961.1 - 0.019 14.8 1.0 0.037 13.8 0.7 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2315) HTH_IclR PF09339.5 KII71961.1 - 0.033 13.7 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 KII71961.1 - 0.057 13.4 0.2 0.14 12.2 0.1 1.7 1 0 0 1 1 1 0 Transposase HTH_19 PF12844.2 KII71961.1 - 0.077 13.0 0.2 2.5 8.2 0.0 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_17 PF12728.2 KII71961.1 - 0.14 12.3 1.0 0.29 11.4 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain DUF4371 PF14291.1 KII71963.1 - 0.028 13.9 0.3 0.041 13.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) NrfD PF03916.9 KII71965.1 - 0.0071 15.8 0.0 0.0089 15.4 0.0 1.1 1 0 0 1 1 1 1 Polysulphide reductase, NrfD DBD_Tnp_Hermes PF10683.4 KII71965.1 - 0.054 12.9 0.0 0.092 12.2 0.0 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain DDE_Tnp_IS1595 PF12762.2 KII71967.1 - 3.8e-05 23.5 0.0 5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain C1_4 PF07975.7 KII71968.1 - 1.2e-06 28.3 26.2 3.7e-06 26.8 10.2 2.8 2 1 0 2 2 2 2 TFIIH C1-like domain zf-HIT PF04438.11 KII71968.1 - 0.0018 17.8 1.9 0.0018 17.8 1.3 4.7 4 1 0 4 4 4 1 HIT zinc finger zf-AN1 PF01428.11 KII71968.1 - 0.025 14.4 5.7 0.025 14.4 4.0 4.4 2 2 3 5 5 5 0 AN1-like Zinc finger DZR PF12773.2 KII71968.1 - 0.071 12.9 22.0 0.5 10.2 1.3 3.0 1 1 1 2 2 2 0 Double zinc ribbon C1_1 PF00130.17 KII71968.1 - 1.5 8.5 24.1 0.3 10.8 8.0 3.4 2 2 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-FPG_IleRS PF06827.9 KII71968.1 - 4.9 6.8 19.2 0.98 9.1 0.4 4.3 4 1 1 5 5 5 0 Zinc finger found in FPG and IleRS PHF5 PF03660.9 KII71968.1 - 6.4 6.8 13.2 0.9 9.6 5.0 2.2 2 0 0 2 2 2 0 PHF5-like protein Ssl1 PF04056.9 KII71969.1 - 2.6e-49 167.4 0.4 3.2e-49 167.1 0.3 1.1 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.1 KII71969.1 - 3.8e-11 43.4 0.0 4.8e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KII71969.1 - 1.7e-08 34.3 0.1 2.3e-08 33.9 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Plasmid_RAQPRD PF09686.5 KII71971.1 - 0.0084 16.1 0.0 4.2 7.5 0.0 2.1 2 0 0 2 2 2 2 Plasmid protein of unknown function (Plasmid_RAQPRD) XOO_2897-deam PF14440.1 KII71973.1 - 0.12 12.0 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase DUF1778 PF08681.6 KII71974.1 - 7.1e-22 77.0 1.1 1.3e-21 76.1 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1778) Acetyltransf_7 PF13508.1 KII71974.1 - 9.2e-13 48.1 0.0 1.6e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KII71974.1 - 0.00013 21.9 0.0 0.00033 20.6 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KII71974.1 - 0.018 15.1 0.2 0.046 13.8 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KII71974.1 - 0.031 14.4 0.0 0.056 13.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ESCRT-II PF05871.7 KII71976.1 - 0.035 14.0 0.2 0.075 12.9 0.0 1.6 2 0 0 2 2 2 0 ESCRT-II complex subunit DUF4129 PF13559.1 KII71981.1 - 0.0025 17.7 0.1 0.0044 16.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) zf-CCHC PF00098.18 KII71981.1 - 0.0068 16.2 0.7 0.018 14.9 0.5 1.7 1 0 0 1 1 1 1 Zinc knuckle Lysyl_oxidase PF01186.12 KII71982.1 - 0.012 15.1 0.1 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Lysyl oxidase Ldl_recept_a PF00057.13 KII71984.1 - 1.8e-28 98.1 51.7 3.6e-12 45.9 8.8 3.5 2 1 2 4 4 4 3 Low-density lipoprotein receptor domain class A Flavokinase PF01687.12 KII71987.1 - 0.00014 21.7 1.7 0.0014 18.5 1.2 2.2 1 1 0 1 1 1 1 Riboflavin kinase DUF512 PF04459.7 KII71987.1 - 0.11 11.5 0.0 0.28 10.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF512) Ribosomal_L7Ae PF01248.21 KII71990.1 - 6.3e-21 73.6 0.0 1e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PLAC8 PF04749.12 KII71992.1 - 1.1e-10 41.9 4.5 1.4e-10 41.6 3.1 1.1 1 0 0 1 1 1 1 PLAC8 family HSP20 PF00011.16 KII71994.1 - 7.2e-17 61.1 0.4 1.2e-07 31.5 0.1 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family Ribosomal_L17 PF01196.14 KII71996.1 - 0.034 14.7 0.0 0.066 13.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L17 Kelch_4 PF13418.1 KII71998.1 - 7.1e-24 83.3 7.0 4.1e-05 23.2 0.0 6.0 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII71998.1 - 7.1e-23 79.8 6.0 2e-06 27.2 0.1 5.4 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 KII71998.1 - 1.4e-22 78.8 13.7 2.2e-05 24.4 0.0 6.6 5 2 1 6 6 6 5 Kelch motif Kelch_3 PF13415.1 KII71998.1 - 2.4e-19 68.9 1.8 0.00064 19.8 0.0 5.2 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KII71998.1 - 3.7e-18 64.5 4.5 5.7e-05 22.7 0.0 6.0 5 1 0 5 5 5 4 Kelch motif Kelch_5 PF13854.1 KII71998.1 - 1.4e-15 56.8 8.0 0.0031 17.4 0.0 5.6 5 0 0 5 5 5 4 Kelch motif IL31 PF15209.1 KII72000.1 - 0.01 15.4 0.2 0.026 14.1 0.1 1.6 1 0 0 1 1 1 1 Interleukin 31 MCLC PF05934.6 KII72001.1 - 0.053 11.8 0.0 0.072 11.3 0.0 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) ABC2_membrane_2 PF12679.2 KII72002.1 - 0.094 11.5 1.1 0.14 11.0 0.8 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein IL31 PF15209.1 KII72003.1 - 0.0027 17.3 0.7 0.0043 16.6 0.5 1.3 1 0 0 1 1 1 1 Interleukin 31 Oxidored_q3 PF00499.15 KII72003.1 - 1.3 8.8 6.6 1.7 8.4 4.6 1.4 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 MTHFR PF02219.12 KII72006.1 - 0.13 11.2 0.1 0.16 11.0 0.1 1.1 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase PfkB PF00294.19 KII72008.1 - 2.4e-50 171.4 0.0 2.7e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase BsuBI_PstI_RE PF06616.6 KII72008.1 - 0.066 12.0 0.0 0.092 11.5 0.0 1.2 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease C-terminus Shisa PF13908.1 KII72009.1 - 0.002 18.3 0.7 0.0029 17.7 0.5 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Podoplanin PF05808.6 KII72009.1 - 0.1 12.1 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Podoplanin DUF912 PF06024.7 KII72009.1 - 0.11 12.5 0.2 0.24 11.4 0.0 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3401 PF11881.3 KII72011.1 - 0.028 13.8 0.1 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3401) Dimer_Tnp_hAT PF05699.9 KII72012.1 - 0.00034 20.1 0.1 0.00096 18.7 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2002 PF09400.5 KII72012.1 - 0.028 14.1 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2002) CxxCxxCC PF03692.10 KII72012.1 - 0.16 12.4 0.7 7.7 7.0 0.0 2.8 3 0 0 3 3 3 0 Putative zinc- or iron-chelating domain Cation_efflux PF01545.16 KII72013.1 - 1.1e-34 119.7 10.4 1.4e-34 119.5 7.2 1.1 1 0 0 1 1 1 1 Cation efflux family ACT_5 PF13710.1 KII72013.1 - 0.082 12.7 0.8 0.68 9.7 0.1 2.4 2 0 0 2 2 2 0 ACT domain Dymeclin PF09742.4 KII72014.1 - 0.017 13.2 10.1 0.021 12.9 7.0 1.0 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein Glu_synthase PF01645.12 KII72014.1 - 0.088 11.7 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase Dymeclin PF09742.4 KII72015.1 - 0.0063 14.6 13.0 0.012 13.7 9.0 1.6 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Fes1 PF08609.5 KII72016.1 - 0.0062 16.9 1.8 0.039 14.4 0.2 2.3 1 1 1 2 2 2 1 Nucleotide exchange factor Fes1 FYVE PF01363.16 KII72017.1 - 2.3e-11 43.4 19.4 1.5e-10 40.8 13.4 2.1 1 1 0 1 1 1 1 FYVE zinc finger PmrD PF11183.3 KII72017.1 - 0.12 12.2 1.1 0.28 10.9 0.2 1.9 1 1 1 2 2 2 0 Polymyxin resistance protein PmrD PHF5 PF03660.9 KII72017.1 - 0.45 10.6 13.2 0.32 11.0 7.8 1.7 2 1 0 2 2 2 0 PHF5-like protein UNC-79 PF14776.1 KII72017.1 - 1.8 6.8 9.5 2.3 6.4 6.6 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 FYVE_2 PF02318.11 KII72017.1 - 6.8 6.6 14.7 11 5.9 9.8 1.8 1 1 0 1 1 1 0 FYVE-type zinc finger PB1 PF00564.19 KII72018.1 - 6.9e-12 44.8 0.1 1.2e-11 44.1 0.1 1.4 1 0 0 1 1 1 1 PB1 domain DUF4221 PF13970.1 KII72019.1 - 0.0051 16.1 0.5 0.0068 15.7 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4221) DUF2666 PF10869.3 KII72019.1 - 0.014 15.4 0.8 0.029 14.3 0.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) DUF2348 PF09807.4 KII72021.1 - 0.041 12.9 0.1 0.041 12.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2348) DUF552 PF04472.7 KII72021.1 - 0.051 13.4 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF552) Herpes_UL21 PF03252.8 KII72022.1 - 0.028 12.9 0.0 0.033 12.6 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL21 Tubulin-binding PF00418.14 KII72025.1 - 0.05 13.2 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat KorB PF08535.5 KII72025.1 - 0.1 12.7 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 KorB domain WD40 PF00400.27 KII72026.1 - 9.4e-15 53.8 4.7 4.6e-08 32.6 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.3 KII72026.1 - 0.03 12.4 1.0 0.56 8.2 0.0 2.6 2 1 0 3 3 3 0 Nucleoporin Nup120/160 RVT_1 PF00078.22 KII72029.1 - 2.8e-07 30.1 0.1 7.9e-07 28.6 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_1 PF03184.14 KII72030.1 - 3.6e-11 42.6 0.0 6e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII72030.1 - 0.019 14.7 0.5 0.03 14.1 0.4 1.3 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain VirDNA-topo-I_N PF09266.5 KII72030.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Viral DNA topoisomerase I, N-terminal FragX_IP PF05994.6 KII72032.1 - 9.7e-48 162.5 2.4 1.2e-47 162.3 1.7 1.0 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family PufQ PF05398.6 KII72034.1 - 0.024 14.6 0.3 0.035 14.1 0.2 1.3 1 0 0 1 1 1 0 PufQ cytochrome subunit DUF3977 PF13122.1 KII72034.1 - 0.14 12.0 0.5 0.25 11.1 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3977) RasGEF_N_2 PF14663.1 KII72037.1 - 0.016 15.1 0.0 0.058 13.3 0.0 1.8 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Proteasom_PSMB PF10508.4 KII72037.1 - 0.14 10.4 0.1 0.17 10.1 0.0 1.0 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit CLU PF13236.1 KII72039.1 - 2.2e-68 229.9 0.0 3.5e-68 229.3 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 KII72039.1 - 3.4e-39 134.4 0.0 7.8e-39 133.3 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.1 KII72039.1 - 8.5e-13 48.2 0.4 2.8e-12 46.6 0.3 2.0 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.1 KII72039.1 - 2.8e-09 36.7 3.4 2.1e-07 30.7 0.3 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat DUF727 PF05303.7 KII72039.1 - 1.5e-05 24.7 0.0 4.7e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_10 PF13374.1 KII72039.1 - 0.0011 18.8 0.0 1.2 9.1 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat Kelch_4 PF13418.1 KII72041.1 - 7.9e-05 22.3 1.6 0.0007 19.3 0.2 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII72041.1 - 0.00013 21.9 4.0 0.00093 19.2 0.2 2.7 3 1 0 3 3 3 1 Kelch motif Kelch_3 PF13415.1 KII72041.1 - 0.00058 19.9 0.5 0.038 14.1 0.1 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.20 KII72041.1 - 0.0024 17.3 6.0 0.42 10.2 0.8 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 KII72042.1 - 5.7e-10 38.9 0.1 1.6e-07 31.1 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII72042.1 - 8e-05 22.1 3.0 0.12 11.9 0.8 2.5 2 1 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII72042.1 - 0.00035 20.2 0.6 0.058 13.1 0.1 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.1 KII72042.1 - 0.023 14.6 0.5 0.046 13.7 0.1 1.6 2 0 0 2 2 2 0 Kelch motif Desulfoferrodox PF01880.13 KII72042.1 - 0.13 12.5 0.1 0.17 12.1 0.1 1.2 1 0 0 1 1 1 0 Desulfoferrodoxin Kelch_4 PF13418.1 KII72043.1 - 0.00018 21.2 0.7 0.00051 19.7 0.1 1.9 1 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.1 KII72043.1 - 0.00078 19.5 0.1 0.009 16.1 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII72043.1 - 0.0049 16.9 0.9 0.61 10.3 0.1 2.4 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII72043.1 - 0.0099 15.4 0.7 0.92 9.1 0.2 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 KII72046.1 - 2.3e-17 62.3 13.5 0.0003 20.8 0.1 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.20 KII72046.1 - 1.4e-11 43.7 18.8 0.0015 18.0 0.8 7.5 8 0 0 8 8 8 4 Kelch motif Kelch_5 PF13854.1 KII72046.1 - 2.1e-10 40.2 4.5 0.0079 16.1 0.0 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.1 KII72046.1 - 7.3e-09 35.5 8.7 0.015 15.4 0.0 5.2 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII72046.1 - 1.4e-08 34.1 5.6 0.012 15.3 0.0 5.6 6 1 0 6 6 6 3 Kelch motif Kelch_4 PF13418.1 KII72046.1 - 6.9e-08 32.1 19.6 0.00013 21.6 0.2 6.6 6 1 1 7 7 7 2 Galactose oxidase, central domain SNAP PF14938.1 KII72049.1 - 1.8e-05 24.0 1.4 2.1e-05 23.7 0.9 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP HTH_Tnp_Tc5 PF03221.11 KII72051.1 - 1e-09 38.0 0.5 1.6e-09 37.4 0.3 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 KII72051.1 - 0.019 14.1 0.8 0.047 12.8 0.0 1.9 2 1 1 3 3 3 0 DDE superfamily endonuclease DUF2315 PF10231.4 KII72051.1 - 0.083 12.7 2.5 0.16 11.8 1.7 1.6 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2315) DDE_1 PF03184.14 KII72052.1 - 4.1e-30 104.5 0.1 4.5e-28 97.8 0.1 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease Ufd2P_core PF10408.4 KII72053.1 - 1.3e-27 96.3 1.0 1.4e-27 96.2 0.7 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 KII72053.1 - 4.9e-15 55.2 0.4 9.1e-15 54.3 0.3 1.5 1 0 0 1 1 1 1 U-box domain Ufd2P_core PF10408.4 KII72054.1 - 1.8e-11 43.0 0.1 1.9e-11 42.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core RVT_1 PF00078.22 KII72056.1 - 1.2e-05 24.7 0.0 4.2e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII72057.1 - 3.6e-10 39.9 0.0 4.2e-08 33.3 0.0 2.4 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72057.1 - 0.0023 17.4 0.1 0.0048 16.3 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII72060.1 - 3.2e-05 23.7 0.0 3.8e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease VCBS PF13517.1 KII72062.1 - 3.4e-07 30.5 2.0 6.8e-06 26.3 0.2 2.0 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII72062.1 - 0.0012 18.4 1.0 1.2 8.9 0.8 2.4 2 0 0 2 2 2 2 FG-GAP repeat Peptidase_M4_C PF02868.10 KII72064.1 - 0.08 12.6 0.1 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 Thermolysin metallopeptidase, alpha-helical domain DUF4261 PF14080.1 KII72065.1 - 0.051 13.3 0.0 0.085 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) DDE_3 PF13358.1 KII72067.1 - 0.027 14.2 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Peptidase_C65 PF10275.4 KII72068.1 - 0.051 12.9 1.2 0.059 12.7 0.8 1.0 1 0 0 1 1 1 0 Peptidase C65 Otubain Pex19 PF04614.7 KII72068.1 - 0.17 11.4 0.0 0.23 11.0 0.0 1.1 1 0 0 1 1 1 0 Pex19 protein family Ldl_recept_a PF00057.13 KII72070.1 - 0.00021 21.1 23.1 0.0015 18.3 15.0 2.6 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A DSHCT PF08148.7 KII72072.1 - 2.7e-30 104.9 0.0 3e-30 104.7 0.0 1.0 1 0 0 1 1 1 1 DSHCT (NUC185) domain RRM_6 PF14259.1 KII72073.1 - 4.2e-09 36.2 0.0 2.4e-08 33.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII72073.1 - 2.4e-05 23.8 0.0 9.7e-05 21.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII72073.1 - 0.025 14.4 0.0 0.13 12.1 0.0 2.1 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 KII72074.1 - 2.6e-05 23.9 11.6 7.2e-05 22.5 3.0 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 KII72074.1 - 0.7 9.6 8.6 2.1 8.0 1.1 2.7 1 1 1 2 2 2 0 Zinc knuckle zf-met PF12874.2 KII72075.1 - 0.0017 18.5 0.2 0.0053 16.9 0.1 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KII72075.1 - 0.0036 17.3 0.1 0.0036 17.3 0.1 2.2 3 1 0 3 3 3 1 Zinc-finger double-stranded RNA-binding RFXA_RFXANK_bdg PF15289.1 KII72075.1 - 0.03 14.4 2.6 0.036 14.2 1.8 1.2 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain zf-C2H2_2 PF12756.2 KII72075.1 - 0.032 14.3 0.5 0.032 14.3 0.4 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 KII72075.1 - 0.036 14.3 0.4 0.1 12.9 0.3 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII72075.1 - 0.052 13.8 0.1 0.12 12.7 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger DUF4355 PF14265.1 KII72075.1 - 1.8 8.5 9.3 3.6 7.5 6.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4355) DUF2358 PF10184.4 KII72076.1 - 0.00037 20.4 1.0 0.0005 19.9 0.7 1.3 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) Pentaxin PF00354.12 KII72076.1 - 0.062 12.7 0.7 0.071 12.5 0.5 1.2 1 0 0 1 1 1 0 Pentaxin family DUF3885 PF13021.1 KII72076.1 - 2.1 8.1 5.0 0.81 9.4 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3885) YhdB PF14148.1 KII72079.1 - 0.044 13.5 0.4 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 YhdB-like protein DUF1870 PF08965.5 KII72079.1 - 0.069 12.8 0.2 0.2 11.3 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1870) Guanylate_cyc PF00211.15 KII72080.1 - 2.2e-53 180.3 0.4 3.2e-53 179.8 0.3 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.12 KII72080.1 - 2.2e-17 62.9 0.3 3.4e-17 62.3 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KII72080.1 - 2.1e-16 59.8 1.1 2.1e-16 59.8 0.7 1.6 2 0 0 2 2 2 1 Protein kinase domain HNOBA PF07701.9 KII72080.1 - 0.023 13.9 0.3 0.043 13.0 0.2 1.4 1 0 0 1 1 1 0 Heme NO binding associated FYVE_2 PF02318.11 KII72081.1 - 0.023 14.6 10.4 0.029 14.2 7.2 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger DUF2897 PF11446.3 KII72081.1 - 0.068 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) DUF4637 PF15470.1 KII72081.1 - 0.2 11.2 3.5 0.32 10.6 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) zf-B_box PF00643.19 KII72081.1 - 1.6 8.6 12.6 4.2 7.3 8.7 1.8 1 1 0 1 1 1 0 B-box zinc finger DnaB_2 PF07261.6 KII72083.1 - 0.0024 17.4 0.1 0.007 15.9 0.0 1.7 2 0 0 2 2 2 1 Replication initiation and membrane attachment DnaB_2 PF07261.6 KII72084.1 - 0.025 14.1 0.0 0.051 13.1 0.0 1.6 1 0 0 1 1 1 0 Replication initiation and membrane attachment SNAP PF14938.1 KII72087.1 - 7.1e-05 22.0 1.0 9.9e-05 21.6 0.7 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF3105 PF11303.3 KII72087.1 - 0.034 13.9 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3105) Torsin PF06309.6 KII72087.1 - 0.065 13.1 0.2 0.089 12.6 0.1 1.2 1 0 0 1 1 1 0 Torsin NSF PF02071.15 KII72087.1 - 0.079 13.5 5.6 9.1 7.3 0.0 4.1 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat SNAP PF14938.1 KII72088.1 - 3.4e-11 42.8 2.7 4.1e-11 42.5 1.9 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII72088.1 - 8.1e-05 22.1 2.8 0.00023 20.7 0.6 2.5 1 1 1 2 2 2 1 TPR repeat TPR_19 PF14559.1 KII72088.1 - 0.0013 19.0 0.5 0.28 11.5 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat PPR_3 PF13812.1 KII72088.1 - 0.1 12.9 0.0 0.71 10.3 0.0 2.5 3 0 0 3 3 3 0 Pentatricopeptide repeat domain PPR_2 PF13041.1 KII72088.1 - 0.13 12.2 0.7 0.33 10.9 0.1 1.9 2 0 0 2 2 2 0 PPR repeat family NSF PF02071.15 KII72088.1 - 0.5 11.1 10.2 2.5 9.0 0.2 3.7 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_1 PF00515.23 KII72088.1 - 0.53 9.9 12.1 6.1 6.6 1.4 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII72088.1 - 2 8.5 11.0 4.9 7.3 1.4 4.2 3 1 2 5 5 5 0 Tetratricopeptide repeat DDE_1 PF03184.14 KII72091.1 - 5.6e-20 71.4 0.0 3.5e-11 42.6 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_3 PF13358.1 KII72091.1 - 0.071 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF381 PF04038.7 KII72093.1 - 0.13 12.3 0.1 1.5 8.9 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF381) SNAP PF14938.1 KII72096.1 - 3.3e-10 39.5 1.2 3.8e-10 39.3 0.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP T4SS-DNA_transf PF02534.9 KII72096.1 - 0.00066 18.3 0.9 0.00097 17.8 0.6 1.2 1 0 0 1 1 1 1 Type IV secretory system Conjugative DNA transfer TPR_1 PF00515.23 KII72096.1 - 0.0034 16.9 8.2 0.43 10.2 0.8 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TraG-D_C PF12696.2 KII72096.1 - 0.021 14.7 0.6 0.097 12.5 0.2 2.0 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG TPR_12 PF13424.1 KII72096.1 - 0.025 14.5 0.2 0.4 10.6 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII72096.1 - 0.11 12.5 1.2 22 5.2 0.0 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII72096.1 - 0.17 11.5 1.5 1.6 8.4 1.0 2.5 1 1 0 1 1 1 0 TPR repeat Pam16 PF03656.8 KII72096.1 - 0.23 11.2 0.9 0.4 10.4 0.6 1.5 1 1 0 1 1 1 0 Pam16 NSF PF02071.15 KII72096.1 - 6.3 7.8 6.5 1.2e+02 3.9 0.0 4.7 4 1 1 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat Citrate_ly_lig PF08218.6 KII72101.1 - 0.096 12.1 5.2 1.7 8.0 0.0 3.2 2 2 1 3 3 3 0 Citrate lyase ligase C-terminal domain GHL13 PF14883.1 KII72101.1 - 0.18 10.9 3.9 0.45 9.6 0.4 2.7 2 2 0 2 2 2 0 Hypothetical glycosyl hydrolase family 13 GrpE PF01025.14 KII72101.1 - 0.34 10.4 9.0 3 7.3 0.6 2.6 1 1 0 2 2 2 0 GrpE DUF1342 PF07072.6 KII72101.1 - 0.37 10.4 6.6 0.25 10.9 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1342) CENP-Q PF13094.1 KII72101.1 - 1.4 8.9 14.3 4 7.4 0.7 3.4 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit CCDC-167 PF15188.1 KII72101.1 - 6 6.8 9.3 2.7 7.9 0.4 3.9 2 2 2 4 4 4 0 Coiled-coil domain-containing protein 167 PMC2NT PF08066.7 KII72101.1 - 9.8 6.5 9.0 7.7 6.8 1.1 3.0 3 0 0 3 3 3 0 PMC2NT (NUC016) domain Kinesin PF00225.18 KII72102.1 - 1e-52 178.9 0.3 1e-52 178.9 0.2 1.8 2 0 0 2 2 2 1 Kinesin motor domain DUF2508 PF10704.4 KII72102.1 - 0.085 13.0 3.5 0.99 9.6 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) UPF0184 PF03670.8 KII72102.1 - 0.18 12.0 2.5 3.2 8.0 0.5 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) YkyA PF10368.4 KII72102.1 - 0.48 9.7 8.2 0.82 8.9 5.7 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein ABC2_membrane PF01061.19 KII72103.1 - 2.2e-43 147.8 32.0 3.1e-43 147.3 22.2 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 KII72103.1 - 5e-20 72.1 1.3 5.1e-20 72.1 0.1 1.6 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.2 KII72103.1 - 3.9e-08 32.7 32.9 9.6e-08 31.4 22.8 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.1 KII72103.1 - 2e-06 28.0 0.1 0.012 15.5 0.0 2.5 1 1 0 2 2 2 2 AAA domain ABC2_membrane_2 PF12679.2 KII72103.1 - 0.0046 15.8 14.1 0.0046 15.8 9.8 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein DUF258 PF03193.11 KII72103.1 - 0.017 14.3 0.2 0.031 13.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SbcCD_C PF13558.1 KII72103.1 - 0.027 14.3 0.0 0.066 13.1 0.0 1.6 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Septin PF00735.13 KII72103.1 - 0.074 12.0 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_22 PF13401.1 KII72103.1 - 0.081 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 KII72103.1 - 0.093 12.1 0.1 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Triabin PF03973.8 KII72103.1 - 0.11 12.1 0.8 0.21 11.2 0.5 1.4 1 0 0 1 1 1 0 Triabin DDDD PF10161.4 KII72103.1 - 3 7.5 0.0 3 7.5 0.0 3.2 3 1 1 4 4 4 0 Putative mitochondrial precursor protein tRNA-synt_2c PF01411.14 KII72104.1 - 4.8e-200 665.5 0.0 6.4e-200 665.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 KII72104.1 - 5.6e-14 51.7 1.2 1.2e-13 50.6 0.8 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF455 PF04305.9 KII72104.1 - 0.096 11.9 0.1 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF455) BCIP PF13862.1 KII72105.1 - 0.028 13.9 0.7 0.058 12.9 0.4 1.7 1 1 0 1 1 1 0 p21-C-terminal region-binding protein DUF383 PF04063.9 KII72105.1 - 0.043 13.3 0.1 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF383) Flavokinase PF01687.12 KII72106.1 - 4e-23 81.6 0.0 4.7e-23 81.4 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase DUF373 PF04123.8 KII72107.1 - 0.0007 18.7 6.1 0.00096 18.2 4.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF373) ABC2_membrane_3 PF12698.2 KII72107.1 - 0.27 10.2 14.4 0.35 9.8 10.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Claudin_2 PF13903.1 KII72107.1 - 6.8 6.3 12.7 3.2 7.4 1.9 2.2 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction COG5 PF10392.4 KII72108.1 - 0.036 14.0 0.1 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 Golgi transport complex subunit 5 RBD-FIP PF09457.5 KII72108.1 - 0.15 11.9 0.5 0.4 10.5 0.4 1.7 1 0 0 1 1 1 0 FIP domain Iso_dh PF00180.15 KII72109.1 - 1.8e-67 227.7 0.0 2.1e-67 227.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PHD PF00628.24 KII72112.1 - 4.9e-05 22.9 5.2 0.0001 21.8 3.6 1.5 1 0 0 1 1 1 1 PHD-finger LRR_4 PF12799.2 KII72113.1 - 0.00084 18.8 34.5 0.13 11.9 0.1 8.0 7 2 0 8 8 8 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KII72113.1 - 0.0072 16.2 26.8 1.9 8.8 0.0 8.1 8 1 0 8 8 8 3 Leucine Rich repeat LRR_8 PF13855.1 KII72113.1 - 0.043 13.5 22.9 0.16 11.7 1.4 6.1 4 1 3 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 KII72113.1 - 0.46 10.7 0.1 0.46 10.7 0.0 7.5 6 1 1 7 7 7 0 Leucine Rich Repeat Peptidase_M24 PF00557.19 KII72114.1 - 7.4e-38 130.2 0.0 1e-37 129.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 KII72114.1 - 5.2e-05 23.7 0.0 0.4 11.1 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain rve PF00665.21 KII72116.1 - 2.6e-21 75.9 0.0 3.4e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72116.1 - 0.0011 18.4 0.5 0.0022 17.4 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Poxvirus PF06227.7 KII72117.1 - 0.07 12.6 1.0 0.096 12.2 0.7 1.2 1 0 0 1 1 1 0 dsDNA Poxvirus CRM1_C PF08767.6 KII72118.1 - 2.5e-78 263.2 11.5 2.5e-78 263.2 8.0 3.6 4 0 0 4 4 4 2 CRM1 C terminal Xpo1 PF08389.7 KII72118.1 - 2.2e-25 89.2 14.5 5.2e-25 88.0 4.1 3.9 3 1 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.14 KII72118.1 - 1.1e-11 44.5 2.3 3.3e-11 42.9 0.1 2.8 3 0 0 3 3 3 1 Importin-beta N-terminal domain DDE_3 PF13358.1 KII72119.1 - 9.7e-07 28.6 0.1 5.4e-06 26.2 0.1 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease Ca_chan_IQ PF08763.6 KII72119.1 - 0.11 11.7 0.3 1.7 7.9 0.3 2.2 2 0 0 2 2 2 0 Voltage gated calcium channel IQ domain GTP_EFTU PF00009.22 KII72121.1 - 6.1e-44 149.7 0.1 6.1e-44 149.7 0.1 1.8 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 KII72121.1 - 4.9e-21 74.7 0.1 4.5e-20 71.6 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 KII72121.1 - 1.5e-14 53.8 1.3 2.8e-14 52.9 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 KII72121.1 - 0.00087 18.8 0.6 0.00087 18.8 0.4 2.7 3 0 0 3 3 3 1 Elongation factor Tu domain 4 Gtr1_RagA PF04670.7 KII72121.1 - 0.0072 15.4 0.1 0.026 13.6 0.1 2.1 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KII72121.1 - 0.02 14.8 0.1 0.069 13.1 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Oxysterol_BP PF01237.13 KII72123.1 - 1.3e-16 60.0 0.3 2e-16 59.4 0.2 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein Oxysterol_BP PF01237.13 KII72124.1 - 1.5e-25 89.4 1.9 2.9e-25 88.5 1.3 1.4 1 1 0 1 1 1 1 Oxysterol-binding protein DUF2897 PF11446.3 KII72125.1 - 0.016 15.0 0.4 0.028 14.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) HEAT_2 PF13646.1 KII72127.1 - 3.6e-09 36.7 0.0 7.4e-06 26.1 0.0 3.1 2 1 1 3 3 3 3 HEAT repeats HEAT_EZ PF13513.1 KII72127.1 - 1.8e-07 31.4 0.0 0.34 11.4 0.0 4.3 4 1 0 4 4 4 3 HEAT-like repeat HEAT PF02985.17 KII72127.1 - 5.3e-07 29.1 0.6 1.2 9.4 0.0 5.5 6 0 0 6 6 6 2 HEAT repeat Arm PF00514.18 KII72127.1 - 8.1e-06 25.4 0.0 0.05 13.4 0.0 3.2 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.15 KII72127.1 - 0.0034 15.7 0.1 0.0048 15.2 0.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region CLASP_N PF12348.3 KII72127.1 - 0.026 13.8 0.1 0.047 13.0 0.1 1.4 1 0 0 1 1 1 0 CLASP N terminal Proteasom_PSMB PF10508.4 KII72127.1 - 0.089 11.0 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit FCH PF00611.18 KII72128.1 - 0.012 15.7 1.1 0.019 15.1 0.0 1.9 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain FCH PF00611.18 KII72129.1 - 0.00081 19.5 1.0 0.0068 16.5 0.0 2.8 4 0 0 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain ERp29 PF07749.7 KII72129.1 - 0.4 11.3 4.5 7.1 7.3 0.0 3.0 3 0 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain Cortex-I_coil PF09304.5 KII72130.1 - 0.59 10.2 7.1 0.092 12.7 0.5 2.5 1 1 2 3 3 3 0 Cortexillin I, coiled coil DUF16 PF01519.11 KII72130.1 - 0.91 9.7 8.6 1.8 8.8 3.3 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 CGI-121 PF08617.5 KII72131.1 - 0.072 12.7 0.6 0.19 11.3 0.4 1.7 1 1 0 1 1 1 0 Kinase binding protein CGI-121 TMCO5 PF14992.1 KII72133.1 - 0.018 14.1 0.1 0.022 13.8 0.1 1.0 1 0 0 1 1 1 0 TMCO5 family DEAD PF00270.24 KII72134.1 - 5.2e-39 133.4 0.1 1e-38 132.5 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII72134.1 - 2.5e-24 84.9 0.0 1e-23 82.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.1 KII72134.1 - 6.5e-05 22.1 0.1 0.00012 21.2 0.1 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.10 KII72134.1 - 0.00046 20.0 0.0 0.00099 18.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SURF4 PF02077.10 KII72135.1 - 4.9e-85 285.1 8.8 5.6e-85 284.9 6.1 1.0 1 0 0 1 1 1 1 SURF4 family DUF3938 PF13074.1 KII72135.1 - 0.073 12.9 0.4 0.073 12.9 0.3 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3938) Arv1 PF04161.8 KII72135.1 - 0.35 10.7 5.4 0.63 9.9 0.0 2.6 1 1 1 2 2 2 0 Arv1-like family HR_lesion PF05514.6 KII72135.1 - 8.4 6.2 8.4 0.66 9.8 0.4 2.5 1 1 0 2 2 2 0 HR-like lesion-inducing RRM_1 PF00076.17 KII72137.1 - 0.0015 18.1 0.0 0.0021 17.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VWC PF00093.13 KII72137.1 - 0.01 15.9 4.9 0.015 15.3 3.4 1.3 1 0 0 1 1 1 0 von Willebrand factor type C domain zf-B_box PF00643.19 KII72137.1 - 0.27 11.1 10.5 0.46 10.4 7.3 1.4 1 0 0 1 1 1 0 B-box zinc finger DUF2296 PF10058.4 KII72137.1 - 2 8.2 7.6 3.2 7.5 5.2 1.3 1 0 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) DcpS_C PF11969.3 KII72138.1 - 9.6e-30 103.1 0.2 1.1e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 KII72138.1 - 2.3e-26 92.1 0.3 2.9e-26 91.8 0.2 1.1 1 0 0 1 1 1 1 HIT domain DDE_1 PF03184.14 KII72139.1 - 4e-08 32.6 0.0 6.8e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.2 KII72140.1 - 1.1e-16 61.0 0.6 1.6e-14 53.9 0.2 2.2 1 1 1 2 2 2 2 ISXO2-like transposase domain DUF3797 PF12677.2 KII72140.1 - 0.3 10.7 3.9 1.8 8.2 1.0 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF3797) Ribonuclease_3 PF00636.21 KII72141.1 - 4.5e-38 130.1 0.0 4.4e-21 75.4 0.0 3.4 3 0 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 KII72141.1 - 1.1e-21 77.0 4.9 2.6e-09 37.1 0.2 4.8 6 0 0 6 6 6 2 Ribonuclease-III-like Dicer_dimer PF03368.9 KII72141.1 - 6.3e-17 61.1 0.1 2.8e-16 59.0 0.0 2.2 2 0 0 2 2 2 1 Dicer dimerisation domain dsrm PF00035.20 KII72141.1 - 3e-12 46.9 1.1 1.3e-05 25.6 0.0 3.9 3 0 0 3 3 3 3 Double-stranded RNA binding motif DEAD PF00270.24 KII72141.1 - 1e-11 44.6 0.0 3.1e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII72141.1 - 4.2e-11 42.5 0.1 1.1e-10 41.1 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII72141.1 - 8.1e-09 35.5 0.0 4.5e-08 33.1 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DDE_Tnp_IS1595 PF12762.2 KII72142.1 - 8.5e-11 41.8 0.2 1.1e-10 41.5 0.2 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain Response_reg PF00072.19 KII72143.1 - 1.2e-25 89.7 0.0 1.9e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.23 KII72143.1 - 1.5e-24 85.7 0.1 3.3e-24 84.5 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal DUF1610 PF07754.6 KII72144.1 - 0.06 13.4 0.2 15 5.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) RB_A PF01858.12 KII72145.1 - 0.075 12.6 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain DUF2096 PF09869.4 KII72146.1 - 0.014 15.2 0.5 0.019 14.8 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) MarR PF01047.17 KII72147.1 - 0.08 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 MarR family zf-UBR PF02207.15 KII72153.1 - 2.9e-12 46.1 17.6 2.9e-12 46.1 12.2 2.7 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 KII72153.1 - 0.0038 16.9 0.0 0.009 15.7 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS rve PF00665.21 KII72154.1 - 1.4e-19 70.4 0.0 4.3e-19 68.7 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII72154.1 - 3.8e-19 68.8 0.0 8.6e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII72154.1 - 2e-06 27.6 0.1 7e-06 25.8 0.1 2.0 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII72154.1 - 0.0015 18.0 0.3 0.0062 16.0 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Asp_protease PF09668.5 KII72154.1 - 0.0023 17.5 0.6 0.005 16.4 0.4 1.6 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 KII72154.1 - 0.0048 17.3 0.0 0.012 16.1 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease zf-UBR PF02207.15 KII72155.1 - 3.8e-10 39.3 20.8 1.1e-09 37.8 14.4 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Flu_PB1 PF00602.12 KII72161.1 - 0.0071 14.1 0.3 0.008 13.9 0.2 1.0 1 0 0 1 1 1 1 Influenza RNA-dependent RNA polymerase subunit PB1 EGF_2 PF07974.8 KII72163.1 - 0.00026 21.0 18.9 0.021 15.0 3.6 2.7 2 0 0 2 2 2 2 EGF-like domain EGF PF00008.22 KII72163.1 - 0.0014 18.5 4.2 0.0014 18.5 2.9 2.7 2 0 0 2 2 2 1 EGF-like domain EGF_3 PF12947.2 KII72163.1 - 0.032 14.2 5.5 0.032 14.2 3.8 2.7 2 0 0 2 2 2 0 EGF domain Laminin_EGF PF00053.19 KII72163.1 - 1.4 8.9 16.7 0.97 9.4 2.2 2.5 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) FXa_inhibition PF14670.1 KII72163.1 - 6.1 7.0 16.1 5.7 7.1 2.9 2.7 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Disintegrin PF00200.18 KII72165.1 - 7.1e-12 45.3 15.3 1.2e-11 44.6 10.6 1.3 1 0 0 1 1 1 1 Disintegrin Reprolysin PF01421.14 KII72165.1 - 0.00011 21.8 0.1 0.00057 19.5 0.0 2.0 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.1 KII72165.1 - 0.008 16.7 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 KII72165.1 - 0.051 13.0 0.0 0.066 12.7 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like RRM_6 PF14259.1 KII72167.1 - 7.7e-05 22.5 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII72167.1 - 0.014 15.0 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF164 PF02591.10 KII72168.1 - 0.011 15.5 0.1 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 Putative zinc ribbon domain C1_1 PF00130.17 KII72168.1 - 0.012 15.3 0.2 0.023 14.4 0.1 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) UPF0547 PF10571.4 KII72168.1 - 0.099 12.3 0.3 0.18 11.5 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Vfa1 PF08432.5 KII72169.1 - 0.0081 16.2 9.0 0.009 16.0 6.3 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF2890 PF11081.3 KII72169.1 - 0.081 12.9 4.5 0.093 12.7 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) DUF1510 PF07423.6 KII72169.1 - 0.22 10.8 11.5 0.27 10.5 8.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 KII72169.1 - 0.4 8.6 4.2 0.38 8.7 2.9 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.7 KII72169.1 - 0.63 9.8 6.4 0.69 9.7 4.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SRP-alpha_N PF04086.8 KII72169.1 - 9.8 5.4 14.8 12 5.1 10.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Rrp15p PF07890.7 KII72170.1 - 2.1e-05 24.5 3.3 2.7e-05 24.2 2.3 1.5 1 1 0 1 1 1 1 Rrp15p DUF755 PF05501.6 KII72170.1 - 0.094 12.7 3.9 0.13 12.3 2.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF755) Bcl-2 PF00452.14 KII72171.1 - 0.14 12.2 1.5 1.2 9.2 0.0 3.2 4 1 0 4 4 4 0 Apoptosis regulator proteins, Bcl-2 family rve PF00665.21 KII72172.1 - 4.9e-25 87.9 0.1 1.4e-24 86.4 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII72172.1 - 7.3e-22 77.7 0.0 1.5e-21 76.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII72172.1 - 2.4e-05 24.1 0.0 5.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII72172.1 - 0.00021 20.7 0.0 0.00063 19.2 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Peptidase_C39 PF03412.10 KII72173.1 - 0.021 14.6 0.1 0.037 13.8 0.1 1.4 1 0 0 1 1 1 0 Peptidase C39 family THDPS_N PF14790.1 KII72173.1 - 0.069 12.7 0.3 0.073 12.6 0.2 1.2 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal TSNR_N PF04705.7 KII72173.1 - 0.071 12.9 0.1 0.85 9.4 0.0 2.2 1 1 0 2 2 2 0 Thiostrepton-resistance methylase, N terminus Peroxidase_2 PF01328.12 KII72173.1 - 0.16 10.6 0.2 0.17 10.4 0.1 1.0 1 0 0 1 1 1 0 Peroxidase, family 2 YvrJ PF12841.2 KII72174.1 - 0.045 13.0 0.2 0.079 12.2 0.1 1.4 1 0 0 1 1 1 0 YvrJ protein family stn_TNFRSF12A PF12191.3 KII72176.1 - 0.018 15.0 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF3487 PF11990.3 KII72176.1 - 0.093 12.1 0.9 0.13 11.7 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Glycophorin_A PF01102.13 KII72176.1 - 0.12 12.1 0.1 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A TMEM156 PF15106.1 KII72176.1 - 0.19 10.9 0.8 0.25 10.5 0.5 1.2 1 0 0 1 1 1 0 TMEM156 protein family Chitin_synth_1N PF08407.6 KII72177.1 - 0.15 11.7 0.4 0.38 10.4 0.1 1.8 2 0 0 2 2 2 0 Chitin synthase N-terminal Serpin PF00079.15 KII72178.1 - 1.3e-20 73.9 0.2 1.4e-15 57.3 0.0 2.1 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) DUF605 PF04652.11 KII72178.1 - 0.029 13.7 4.6 0.032 13.6 3.2 1.1 1 0 0 1 1 1 0 Vta1 like CDC45 PF02724.9 KII72178.1 - 0.24 9.3 13.1 0.27 9.2 9.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 KII72178.1 - 6 6.1 18.7 8 5.7 13.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) HTH_Tnp_Tc3_2 PF01498.13 KII72188.1 - 0.0023 17.9 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 Transposase RVT_1 PF00078.22 KII72192.1 - 1.3e-05 24.6 0.0 2.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ROF PF07073.7 KII72192.1 - 0.035 14.1 0.1 0.075 13.0 0.1 1.4 1 0 0 1 1 1 0 Modulator of Rho-dependent transcription termination (ROF) Peripla_BP_5 PF13433.1 KII72193.1 - 0.031 13.0 0.0 0.042 12.5 0.0 1.1 1 0 0 1 1 1 0 Periplasmic binding protein domain RVT_1 PF00078.22 KII72194.1 - 4.1e-10 39.3 0.2 1.1e-09 37.9 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII72194.1 - 0.00017 21.7 0.0 0.0011 19.1 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain DDE_3 PF13358.1 KII72195.1 - 4.8e-06 26.3 0.2 9.5e-06 25.4 0.1 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease SIN1 PF05422.7 KII72196.1 - 3.6e-07 29.0 1.2 4e-07 28.9 0.8 1.1 1 0 0 1 1 1 1 Stress-activated map kinase interacting protein 1 (SIN1) Mannosyl_trans PF05007.8 KII72197.1 - 0.0026 17.4 0.1 0.0028 17.3 0.1 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) MULE PF10551.4 KII72198.1 - 2e-09 37.4 0.0 9.6e-09 35.2 0.0 2.1 2 0 0 2 2 2 1 MULE transposase domain zf-CDGSH PF09360.5 KII72202.1 - 2.3e-10 40.0 1.6 4.6e-10 39.1 1.1 1.6 1 1 0 1 1 1 1 Iron-binding zinc finger CDGSH type NUDIX PF00293.23 KII72203.1 - 1.3e-08 34.6 0.0 1.4e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain DUF1173 PF06666.6 KII72203.1 - 0.096 11.5 0.0 0.14 10.9 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1173) Las1 PF04031.8 KII72205.1 - 1.3e-11 44.4 0.8 2.4e-11 43.5 0.6 1.4 1 0 0 1 1 1 1 Las1-like GDE_N PF12439.3 KII72205.1 - 0.03 13.5 0.0 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme N terminal zf-C3HC4_2 PF13923.1 KII72206.1 - 5.3e-08 32.7 13.8 5.3e-08 32.7 9.6 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KII72206.1 - 1.6e-07 30.9 9.1 2.8e-07 30.1 6.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KII72206.1 - 3.1e-07 29.9 11.9 6.2e-07 28.9 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KII72206.1 - 4.9e-07 29.4 12.5 8.9e-07 28.6 8.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KII72206.1 - 0.00012 21.6 13.0 0.00024 20.7 9.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KII72206.1 - 0.00047 19.9 13.7 0.0009 19.0 9.5 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KII72206.1 - 0.077 12.7 12.1 0.18 11.5 8.4 1.7 1 0 0 1 1 1 0 RING-type zinc-finger NADH_u_ox_C PF12853.2 KII72206.1 - 0.12 12.1 0.2 0.28 10.9 0.1 1.6 1 0 0 1 1 1 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit zf-RING_6 PF14835.1 KII72206.1 - 0.36 10.6 5.6 1.2 9.0 3.9 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Uso1_p115_head PF04869.9 KII72207.1 - 2.5e-15 56.0 5.1 4e-15 55.3 3.5 1.2 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Myosin_tail_1 PF01576.14 KII72207.1 - 9e-05 20.4 3.3 0.00012 19.9 2.3 1.2 1 0 0 1 1 1 1 Myosin tail APG6 PF04111.7 KII72207.1 - 0.00019 20.5 2.8 0.00031 19.8 1.9 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 CALCOCO1 PF07888.6 KII72207.1 - 0.0018 16.6 3.5 0.0025 16.1 2.4 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3585 PF12130.3 KII72207.1 - 0.0029 17.4 1.5 0.015 15.1 1.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3585) IncA PF04156.9 KII72207.1 - 0.005 16.4 1.2 0.013 15.0 0.8 1.7 1 0 0 1 1 1 1 IncA protein CENP-F_leu_zip PF10473.4 KII72207.1 - 0.0076 16.1 4.8 0.031 14.1 3.1 1.8 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin_2 PF01920.15 KII72207.1 - 0.016 14.9 1.8 0.044 13.5 1.2 1.7 1 0 0 1 1 1 0 Prefoldin subunit DUF4472 PF14739.1 KII72207.1 - 0.026 14.9 3.0 0.069 13.6 2.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) DUF730 PF05325.6 KII72207.1 - 0.032 14.0 0.1 0.067 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF730) Vac_Fusion PF02346.11 KII72207.1 - 0.037 13.4 4.2 0.35 10.3 0.4 3.5 3 1 0 3 3 3 0 Chordopoxvirus fusion protein DUF4200 PF13863.1 KII72207.1 - 0.047 13.6 2.5 0.11 12.4 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Syntaxin_2 PF14523.1 KII72207.1 - 0.099 12.6 4.5 0.075 13.0 1.4 2.2 2 0 0 2 2 2 0 Syntaxin-like protein DUF1664 PF07889.7 KII72207.1 - 0.13 12.0 2.8 0.084 12.6 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DivIC PF04977.10 KII72207.1 - 0.24 10.9 4.7 0.46 9.9 0.7 2.9 2 1 1 3 3 3 0 Septum formation initiator TBPIP PF07106.8 KII72207.1 - 0.32 10.5 6.6 0.47 9.9 1.0 2.5 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 KII72207.1 - 0.39 11.0 8.1 0.081 13.2 1.5 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Fib_alpha PF08702.5 KII72207.1 - 0.54 10.3 5.2 0.17 11.9 1.4 1.9 2 0 0 2 2 1 0 Fibrinogen alpha/beta chain family Cep57_CLD_2 PF14197.1 KII72207.1 - 3.7 7.5 10.4 0.37 10.7 2.6 2.6 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DDE_Tnp_IS1595 PF12762.2 KII72209.1 - 3.4e-20 72.4 0.1 4e-20 72.1 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain RVT_1 PF00078.22 KII72210.1 - 1.9e-22 79.7 0.0 3.6e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII72210.1 - 9.2e-06 25.5 0.0 2.5e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.6 KII72210.1 - 7.4e-05 22.7 0.1 0.00014 21.7 0.1 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII72210.1 - 0.004 17.6 0.0 0.01 16.2 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII72210.1 - 0.012 15.1 0.0 0.032 13.8 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII72210.1 - 0.036 13.8 0.0 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease M16C_assoc PF08367.6 KII72211.1 - 0.034 13.0 0.5 0.037 12.8 0.3 1.2 1 0 0 1 1 1 0 Peptidase M16C associated HsdM_N PF12161.3 KII72211.1 - 0.091 13.1 0.3 0.14 12.5 0.2 1.2 1 0 0 1 1 1 0 HsdM N-terminal domain rve PF00665.21 KII72212.1 - 4.6e-14 52.5 0.0 8.2e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII72212.1 - 0.0015 18.5 0.4 0.0071 16.3 0.0 2.0 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII72212.1 - 0.15 11.6 0.8 0.46 10.0 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain zf-C2H2_2 PF12756.2 KII72212.1 - 0.92 9.6 5.4 1.5 8.9 3.7 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) rve PF00665.21 KII72216.1 - 2.1e-14 53.6 0.0 3.7e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII72216.1 - 0.0019 18.1 0.5 0.0085 16.0 0.0 2.0 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII72216.1 - 0.14 11.6 0.8 0.46 10.0 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain zf-C2H2_2 PF12756.2 KII72216.1 - 0.91 9.6 5.4 1.5 8.9 3.7 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Asp_protease_2 PF13650.1 KII72219.1 - 0.00043 20.7 0.1 0.00097 19.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII72219.1 - 0.0011 18.8 0.1 0.0023 17.8 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII72219.1 - 0.0023 17.6 0.1 0.0047 16.7 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII72219.1 - 0.0034 16.9 0.2 0.0078 15.7 0.2 1.6 1 0 0 1 1 1 1 Aspartyl protease Kelch_4 PF13418.1 KII72225.1 - 3.9e-06 26.5 1.2 0.0078 15.9 0.2 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII72225.1 - 0.00019 21.4 0.3 0.3 11.3 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.1 KII72225.1 - 0.00025 21.1 1.4 0.67 10.2 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII72225.1 - 0.0063 16.0 1.4 2.2 7.8 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Myb_DNA-binding PF00249.26 KII72229.1 - 8.8e-05 22.4 0.6 0.0013 18.7 0.2 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain polyprenyl_synt PF00348.12 KII72229.1 - 0.029 13.2 0.7 0.045 12.6 0.5 1.2 1 0 0 1 1 1 0 Polyprenyl synthetase HTH_Tnp_1_2 PF13022.1 KII72229.1 - 0.029 14.1 0.1 0.09 12.5 0.1 1.7 1 1 0 1 1 1 0 Helix-turn-helix of insertion element transposase Myb_DNA-bind_6 PF13921.1 KII72229.1 - 0.068 13.2 0.6 0.068 13.2 0.4 2.5 2 0 0 2 2 2 0 Myb-like DNA-binding domain MULE PF10551.4 KII72232.1 - 7.7e-05 22.7 0.1 0.00023 21.2 0.1 1.9 2 0 0 2 2 2 1 MULE transposase domain BNR PF02012.15 KII72235.1 - 0.0011 18.4 0.1 3.5 7.8 0.0 3.5 3 0 0 3 3 3 2 BNR/Asp-box repeat CBS PF00571.23 KII72237.1 - 1.4e-10 40.7 0.6 9.8e-07 28.4 0.1 2.3 2 0 0 2 2 2 2 CBS domain DUF21 PF01595.15 KII72238.1 - 4.6e-30 104.2 3.0 5.6e-30 103.9 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF21 DUF2566 PF10753.4 KII72238.1 - 1 9.3 7.9 0.18 11.7 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2566) DAGK_cat PF00781.19 KII72239.1 - 0.00022 20.6 0.1 0.00062 19.2 0.0 1.8 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain Hom_end_hint PF05203.11 KII72239.1 - 0.018 14.7 0.4 0.026 14.2 0.3 1.2 1 0 0 1 1 1 0 Hom_end-associated Hint C1_1 PF00130.17 KII72239.1 - 0.22 11.3 5.0 0.14 11.8 1.2 2.3 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RecR PF02132.10 KII72239.1 - 0.41 10.1 6.5 4.7 6.7 1.5 2.7 2 0 0 2 2 2 0 RecR protein DAGK_acc PF00609.14 KII72240.1 - 8.2e-46 156.0 0.0 1.3e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain PMI_typeI PF01238.16 KII72241.1 - 7.1e-79 265.4 1.3 6.8e-77 258.9 0.9 2.2 1 1 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.6 KII72241.1 - 0.0039 16.6 0.0 0.67 9.4 0.0 2.3 2 0 0 2 2 2 2 Cupin domain DAGK_acc PF00609.14 KII72242.1 - 1.4e-43 148.7 0.0 2.8e-43 147.8 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.19 KII72242.1 - 2.1e-18 66.0 0.0 3.8e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.17 KII72242.1 - 0.0015 18.2 5.8 0.0049 16.5 4.0 2.0 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FLYWCH PF04500.11 KII72244.1 - 2.3e-14 53.0 10.5 4.7e-14 52.0 7.3 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 KII72244.1 - 0.00019 21.4 0.2 0.00053 20.0 0.1 1.8 1 0 0 1 1 1 1 MULE transposase domain YEATS PF03366.11 KII72246.1 - 1.4e-27 95.2 0.8 2.1e-27 94.6 0.5 1.3 1 0 0 1 1 1 1 YEATS family Pox_F16 PF04708.7 KII72249.1 - 0.0036 16.6 2.2 0.068 12.4 0.0 2.1 1 1 1 2 2 2 2 Poxvirus F16 protein RNA_pol_L_2 PF13656.1 KII72249.1 - 0.099 12.0 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain G-patch_2 PF12656.2 KII72252.1 - 8.6e-17 60.7 0.0 2e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 DExH-box splicing factor binding site G-patch PF01585.18 KII72252.1 - 2.6e-09 36.6 0.1 5.1e-09 35.7 0.1 1.5 1 0 0 1 1 1 1 G-patch domain KOW PF00467.24 KII72252.1 - 3.6e-07 29.6 4.8 0.03 14.0 0.6 3.7 3 0 0 3 3 3 2 KOW motif DUF4463 PF14703.1 KII72253.1 - 3.4 8.2 7.7 2.4 8.7 0.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4463) Glyco_hydro_31 PF01055.21 KII72254.1 - 1.5e-80 271.2 0.2 1.7e-80 271.0 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 MliC PF09864.4 KII72254.1 - 0.037 13.7 0.0 0.11 12.1 0.0 1.8 1 1 0 1 1 1 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme Porphobil_deam PF01379.15 KII72254.1 - 0.17 10.7 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Porphobilinogen deaminase, dipyromethane cofactor binding domain Gal_mutarotas_2 PF13802.1 KII72255.1 - 4.9e-19 67.9 0.2 1.1e-18 66.8 0.1 1.6 1 0 0 1 1 1 1 Galactose mutarotase-like Glyco_hydro_31 PF01055.21 KII72255.1 - 4.1e-18 65.4 0.1 6.6e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 UAA PF08449.6 KII72256.1 - 2.8e-69 233.3 21.1 2.8e-69 233.3 14.7 1.7 1 1 1 2 2 2 1 UAA transporter family EamA PF00892.15 KII72256.1 - 1.5e-08 34.7 26.9 3.2e-05 23.9 8.9 3.6 4 1 0 4 4 4 2 EamA-like transporter family EmrE PF13536.1 KII72256.1 - 0.0016 18.6 19.9 0.006 16.7 0.1 3.2 3 1 1 4 4 4 2 Multidrug resistance efflux transporter LGT PF01790.13 KII72256.1 - 0.054 12.4 11.4 0.4 9.5 0.3 3.3 3 1 0 3 3 3 0 Prolipoprotein diacylglyceryl transferase MerC PF03203.9 KII72256.1 - 1.9 8.8 16.9 0.25 11.7 0.2 3.8 3 1 0 3 3 3 0 MerC mercury resistance protein SpoVIF PF14069.1 KII72257.1 - 0.11 12.1 0.1 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Stage VI sporulation protein F PgaD PF13994.1 KII72258.1 - 0.036 13.5 0.1 0.065 12.7 0.1 1.4 1 0 0 1 1 1 0 PgaD-like protein Piwi PF02171.12 KII72260.1 - 1.1e-64 218.2 4.3 2.3e-64 217.2 3.0 1.5 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 KII72260.1 - 3.1e-13 49.2 2.9 5.2e-13 48.4 0.8 2.3 2 0 0 2 2 2 1 PAZ domain DUF2703 PF10865.3 KII72260.1 - 0.082 12.8 0.0 0.92 9.4 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF2703) Collagen PF01391.13 KII72261.1 - 3.1 7.4 6.9 0.96 9.0 2.2 2.1 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) RVT_1 PF00078.22 KII72265.1 - 2.6e-10 40.0 0.1 3e-10 39.8 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.1 KII72266.1 - 1 9.8 5.3 4.3 7.8 0.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Sec23_Sec24 PF04810.10 KII72266.1 - 5.6 6.6 7.9 7.3 6.2 1.1 3.1 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger rve PF00665.21 KII72268.1 - 1.4e-22 80.0 0.0 2.2e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72268.1 - 0.019 14.4 0.0 0.048 13.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Phage_rep_org_N PF09681.5 KII72270.1 - 0.12 11.9 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) RVT_1 PF00078.22 KII72271.1 - 2.4e-08 33.5 0.2 3e-08 33.2 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.9 KII72271.1 - 0.03 13.2 0.4 0.053 12.4 0.2 1.5 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.22 KII72274.1 - 8.6e-20 71.0 0.2 3.9e-19 68.8 0.1 2.0 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.22 KII72277.1 - 0.00082 18.7 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NYD-SP12_N PF15015.1 KII72277.1 - 0.052 11.7 0.0 0.067 11.4 0.0 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal Kelch_6 PF13964.1 KII72278.1 - 1.2e-24 85.3 23.5 4.8e-06 26.5 0.2 6.2 4 2 2 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII72278.1 - 2e-20 72.2 22.1 0.0002 21.0 0.1 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KII72278.1 - 2e-19 69.2 13.9 0.0069 16.5 0.0 6.6 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII72278.1 - 4.6e-14 51.6 21.4 1.2e-05 24.7 0.1 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KII72278.1 - 1.5e-11 43.5 12.8 0.00089 18.9 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 KII72278.1 - 1.7e-11 43.8 11.6 0.0014 18.5 0.1 5.2 5 0 0 5 5 5 3 Kelch motif Rax2 PF12768.2 KII72278.1 - 0.0023 17.2 0.1 0.013 14.7 0.1 2.0 1 1 1 2 2 2 1 Cortical protein marker for cell polarity rve PF00665.21 KII72279.1 - 2.7e-10 40.3 0.0 9.2e-10 38.6 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Serpin PF00079.15 KII72283.1 - 3.3e-71 240.4 2.6 3.7e-71 240.2 1.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Phage-tail_1 PF09097.5 KII72283.1 - 0.076 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Baseplate structural protein, domain 1 Serpin PF00079.15 KII72284.1 - 6.4e-56 190.0 0.0 7.2e-56 189.9 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII72286.1 - 9.3e-30 103.9 0.1 1.1e-29 103.7 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PAP2 PF01569.16 KII72288.1 - 7.4e-16 57.9 2.6 7.4e-16 57.9 1.8 1.4 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.1 KII72288.1 - 0.0036 17.5 2.7 0.0036 17.5 1.9 2.2 2 1 0 2 2 2 1 PAP2 superfamily C-terminal PAP2_3 PF14378.1 KII72288.1 - 0.029 13.8 2.6 0.032 13.7 1.2 1.5 1 1 0 1 1 1 0 PAP2 superfamily Mago_nashi PF02792.9 KII72289.1 - 1.4e-44 151.2 0.2 1.5e-44 151.1 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein Pkinase PF00069.20 KII72291.1 - 2.9e-59 200.3 0.0 5.2e-59 199.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII72291.1 - 3.1e-33 114.9 0.0 6.9e-33 113.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KII72291.1 - 5.7e-07 28.7 0.5 4.9e-05 22.4 0.0 2.6 3 0 0 3 3 3 2 Kinase-like Med9 PF07544.8 KII72291.1 - 0.0022 17.6 2.2 0.015 14.9 0.0 2.7 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 HR1 PF02185.11 KII72291.1 - 0.0028 17.3 18.6 0.048 13.4 0.1 3.1 3 0 0 3 3 3 2 Hr1 repeat Retrotrans_gag PF03732.12 KII72292.1 - 0.00016 21.6 0.0 0.00042 20.3 0.0 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.18 KII72292.1 - 0.00075 19.3 1.9 0.00075 19.3 1.3 2.8 3 0 0 3 3 3 2 Zinc knuckle PNMA PF14893.1 KII72292.1 - 0.044 12.8 0.0 0.063 12.3 0.0 1.3 1 0 0 1 1 1 0 PNMA zf-CCHC_6 PF15288.1 KII72292.1 - 0.046 13.4 1.7 0.046 13.4 1.2 1.9 2 0 0 2 2 2 0 Zinc knuckle zf-BED PF02892.10 KII72292.1 - 0.27 11.0 2.6 0.83 9.4 1.8 1.8 1 0 0 1 1 1 0 BED zinc finger zf-CCHC_5 PF14787.1 KII72292.1 - 0.59 9.6 7.2 6.1 6.4 0.7 2.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 KII72292.1 - 2 8.1 8.2 0.81 9.4 1.4 3.0 2 1 1 3 3 3 0 Zinc knuckle Ribosomal_L37e PF01907.14 KII72292.1 - 8.5 6.2 9.4 5.8 6.7 3.9 2.5 2 1 1 3 3 3 0 Ribosomal protein L37e Aldo_ket_red PF00248.16 KII72293.1 - 1.1e-08 34.2 0.0 1.2e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII72294.1 - 8.3e-15 54.3 0.0 1e-14 54.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Serpin PF00079.15 KII72295.1 - 1.1e-48 166.2 1.0 1.3e-48 166.0 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII72296.1 - 1.8e-42 145.8 3.7 2e-42 145.6 2.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PYC_OADA PF02436.13 KII72297.1 - 1.2e-33 116.1 0.0 2.2e-33 115.3 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_lipoyl PF00364.17 KII72297.1 - 5.7e-17 61.1 1.1 5.7e-17 61.1 0.7 1.6 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 KII72297.1 - 2.9e-12 46.0 0.6 6.7e-08 32.0 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD PF00529.15 KII72297.1 - 0.00016 21.1 0.6 0.012 14.9 0.0 2.1 1 1 1 2 2 2 2 HlyD family secretion protein HlyD_2 PF12700.2 KII72297.1 - 0.00021 20.5 0.1 0.00094 18.4 0.0 1.8 1 1 1 2 2 2 1 HlyD family secretion protein HlyD_3 PF13437.1 KII72297.1 - 0.00073 19.8 0.4 1.8 8.9 0.0 2.6 3 0 0 3 3 3 2 HlyD family secretion protein GCV_H PF01597.14 KII72297.1 - 0.012 15.3 0.2 0.028 14.0 0.1 1.6 1 1 0 1 1 1 0 Glycine cleavage H-protein PASTA PF03793.14 KII72297.1 - 0.08 12.5 0.1 0.25 11.0 0.1 1.8 2 0 0 2 2 2 0 PASTA domain 4HBT_2 PF13279.1 KII72299.1 - 4.6e-05 23.8 0.0 4.9e-05 23.7 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.12 KII72299.1 - 0.0087 15.0 0.1 0.01 14.7 0.1 1.1 1 0 0 1 1 1 1 Acyl-ACP thioesterase SNF5 PF04855.7 KII72299.1 - 0.028 13.9 0.1 0.033 13.6 0.1 1.1 1 0 0 1 1 1 0 SNF5 / SMARCB1 / INI1 Di19_C PF14571.1 KII72299.1 - 0.061 13.6 0.2 0.096 13.0 0.1 1.3 1 1 0 1 1 1 0 Stress-induced protein Di19, C-terminal TraI_2 PF07514.6 KII72300.1 - 3.3e-39 134.5 0.0 5e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 Putative helicase DUF1528 PF07515.6 KII72300.1 - 4e-10 39.6 0.0 1e-09 38.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1528) UvrD_C_2 PF13538.1 KII72301.1 - 1.1e-10 41.5 0.0 2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C PF13361.1 KII72301.1 - 1.2e-10 41.4 0.0 1.9e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 KII72301.1 - 5.3e-09 35.8 0.4 1.5e-08 34.3 0.0 1.7 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.13 KII72301.1 - 2e-07 30.7 0.0 0.017 14.6 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Cupin_8 PF13621.1 KII72302.1 - 2.5e-17 63.2 0.7 4.4e-17 62.4 0.5 1.4 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KII72302.1 - 2.7e-07 30.1 0.1 6e-07 29.0 0.0 1.6 1 1 0 1 1 1 1 Cupin superfamily protein NinE PF05322.6 KII72302.1 - 0.011 15.4 0.0 0.03 14.0 0.0 1.7 1 0 0 1 1 1 0 NINE Protein HTH_24 PF13412.1 KII72302.1 - 0.017 14.4 0.1 0.035 13.4 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding JmjC PF02373.17 KII72302.1 - 0.05 13.8 0.1 0.37 11.0 0.0 2.3 1 1 0 2 2 2 0 JmjC domain, hydroxylase DUF1399 PF07173.7 KII72303.1 - 1.6e-05 25.2 1.4 3.2e-05 24.2 0.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1399) DUF2959 PF11172.3 KII72303.1 - 0.056 13.1 0.4 0.056 13.1 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2959) Sigma_reg_N PF13800.1 KII72304.1 - 0.0072 16.3 2.5 0.0075 16.2 0.9 1.7 1 1 0 1 1 1 1 Sigma factor regulator N-terminal DUF485 PF04341.7 KII72304.1 - 0.014 15.1 0.1 0.019 14.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF485 DUF2207 PF09972.4 KII72304.1 - 0.015 13.9 0.7 0.015 13.8 0.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Kinase-like PF14531.1 KII72304.1 - 0.018 14.0 0.1 0.027 13.4 0.0 1.3 1 1 0 1 1 1 0 Kinase-like DUF751 PF05421.6 KII72304.1 - 0.23 11.7 5.8 0.44 10.8 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF751) Reticulon PF02453.12 KII72304.1 - 0.87 9.1 5.9 6.8 6.2 4.1 2.3 1 1 0 1 1 1 0 Reticulon SPC12 PF06645.8 KII72304.1 - 1.1 9.0 4.6 4.3 7.2 3.2 1.9 1 1 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Aldo_ket_red PF00248.16 KII72305.1 - 6.5e-18 64.5 0.0 7.7e-18 64.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII72307.1 - 4.6e-30 104.3 0.1 5.5e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4021 PF13213.1 KII72307.1 - 0.062 12.9 0.7 0.25 10.9 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4021) Aldo_ket_red PF00248.16 KII72308.1 - 1.3e-43 148.8 0.0 1.6e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII72309.1 - 2e-16 59.6 0.0 2.6e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII72310.1 - 2.5e-56 190.5 0.0 3e-56 190.3 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4021 PF13213.1 KII72310.1 - 0.11 12.0 0.4 0.5 10.0 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4021) DUF1543 PF07566.7 KII72313.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1543) RPAP3_C PF13877.1 KII72314.1 - 0.088 12.7 4.9 3.5 7.6 0.3 3.4 3 1 0 3 3 3 0 Potential Monad-binding region of RPAP3 Kinesin PF00225.18 KII72315.1 - 1.9e-105 352.2 2.4 1.9e-105 352.2 1.7 2.2 2 0 0 2 2 1 1 Kinesin motor domain CENP-F_leu_zip PF10473.4 KII72315.1 - 5.8e-12 45.6 58.8 2.2e-06 27.5 15.3 5.5 2 2 3 5 5 5 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.7 KII72315.1 - 3.4e-09 36.5 54.5 0.0016 18.1 9.1 6.0 1 1 4 5 5 5 4 TPR/MLP1/MLP2-like protein IncA PF04156.9 KII72315.1 - 6.4e-08 32.4 60.9 0.00022 20.9 11.3 5.3 1 1 5 6 6 6 3 IncA protein ATG16 PF08614.6 KII72315.1 - 6.6e-08 32.6 59.4 0.008 16.0 3.4 5.3 2 2 3 5 5 5 4 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.14 KII72315.1 - 7.4e-07 27.3 60.3 7.3e-05 20.7 31.7 3.7 2 1 2 4 4 4 3 Myosin tail Filament PF00038.16 KII72315.1 - 8.7e-07 28.6 48.7 8.4e-05 22.1 7.3 5.0 1 1 2 4 4 4 2 Intermediate filament protein Reo_sigmaC PF04582.7 KII72315.1 - 1.2e-05 24.7 28.5 0.024 13.8 3.3 4.7 2 1 3 5 5 4 3 Reovirus sigma C capsid protein Laminin_I PF06008.9 KII72315.1 - 1.9e-05 24.1 44.7 0.014 14.7 9.1 4.4 1 1 3 4 4 4 3 Laminin Domain I Cast PF10174.4 KII72315.1 - 0.00029 19.0 47.7 0.0005 18.2 33.1 1.3 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone DUF972 PF06156.8 KII72315.1 - 0.00035 20.8 54.6 0.66 10.3 2.5 8.3 5 2 4 9 9 9 1 Protein of unknown function (DUF972) Tropomyosin_1 PF12718.2 KII72315.1 - 0.00059 19.6 57.2 0.083 12.7 16.9 4.7 1 1 2 4 4 4 2 Tropomyosin like Fib_alpha PF08702.5 KII72315.1 - 0.0011 19.1 7.7 0.0011 19.1 5.3 5.7 2 1 4 6 6 6 2 Fibrinogen alpha/beta chain family Macoilin PF09726.4 KII72315.1 - 0.0017 16.7 25.2 0.0017 16.7 17.5 3.7 2 1 2 4 4 4 1 Transmembrane protein ADIP PF11559.3 KII72315.1 - 0.0036 17.2 63.2 0.016 15.1 2.3 6.1 3 2 3 6 6 6 4 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.6 KII72315.1 - 0.0037 17.1 33.7 0.0072 16.1 2.4 7.5 4 3 2 7 7 7 1 Flagella accessory protein C (FlaC) ERM PF00769.14 KII72315.1 - 0.0046 16.5 16.8 0.0046 16.5 11.6 4.7 1 1 4 5 5 5 3 Ezrin/radixin/moesin family HOOK PF05622.7 KII72315.1 - 0.0047 14.8 52.1 0.067 10.9 19.7 2.4 1 1 1 2 2 2 2 HOOK protein WEMBL PF05701.6 KII72315.1 - 0.0052 15.3 44.2 0.0047 15.4 20.1 2.7 1 1 1 2 2 2 1 Weak chloroplast movement under blue light Striatin PF08232.7 KII72315.1 - 0.0073 16.6 0.0 0.0073 16.6 0.0 5.8 4 2 1 5 5 5 2 Striatin family HALZ PF02183.13 KII72315.1 - 0.009 15.7 56.4 0.097 12.4 2.7 8.9 7 2 2 9 9 9 4 Homeobox associated leucine zipper GAS PF13851.1 KII72315.1 - 0.013 14.6 62.1 0.028 13.6 12.7 5.3 1 1 4 5 5 5 0 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.3 KII72315.1 - 0.031 14.0 51.9 0.081 12.6 4.5 6.0 2 2 3 5 5 5 0 TATA element modulatory factor 1 TATA binding DUF3584 PF12128.3 KII72315.1 - 0.054 10.8 43.7 0.016 12.6 19.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) APG6 PF04111.7 KII72315.1 - 0.054 12.5 60.9 0.055 12.5 9.0 4.3 1 1 4 5 5 5 0 Autophagy protein Apg6 DUF2968 PF11180.3 KII72315.1 - 0.06 12.7 23.8 0.038 13.3 3.8 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2968) DivIC PF04977.10 KII72315.1 - 0.099 12.1 44.1 0.28 10.7 1.9 7.5 4 2 2 7 7 7 0 Septum formation initiator DUF869 PF05911.6 KII72315.1 - 0.18 10.0 65.4 0.089 11.0 11.7 2.9 2 1 1 3 3 3 0 Plant protein of unknown function (DUF869) Lebercilin PF15619.1 KII72315.1 - 0.22 10.9 56.0 0.57 9.5 1.1 5.9 1 1 4 5 5 5 0 Ciliary protein causing Leber congenital amaurosis disease Cortex-I_coil PF09304.5 KII72315.1 - 0.29 11.2 56.2 0.22 11.5 4.8 6.5 3 2 4 7 7 6 0 Cortexillin I, coiled coil EzrA PF06160.7 KII72315.1 - 0.33 9.0 48.0 0.041 12.0 15.7 4.1 1 1 1 4 4 4 0 Septation ring formation regulator, EzrA TBPIP PF07106.8 KII72315.1 - 0.33 10.4 56.3 0.1 12.1 8.4 5.7 1 1 4 6 6 6 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Rootletin PF15035.1 KII72315.1 - 0.99 9.3 50.9 0.051 13.5 5.9 4.5 1 1 1 3 3 2 0 Ciliary rootlet component, centrosome cohesion Zein-binding PF04576.10 KII72315.1 - 1.2 9.3 17.9 0.06 13.4 0.5 4.7 3 1 1 4 4 2 0 Zein-binding DUF1664 PF07889.7 KII72315.1 - 3 7.6 35.9 0.061 13.1 5.4 6.2 3 2 5 8 8 7 0 Protein of unknown function (DUF1664) DUF948 PF06103.6 KII72315.1 - 3.7 7.4 20.5 0.12 12.3 3.4 5.1 2 2 3 6 6 6 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.7 KII72315.1 - 4.2 7.1 42.0 0.39 10.4 5.5 6.4 2 1 4 7 7 7 0 Laminin Domain II CALCOCO1 PF07888.6 KII72315.1 - 4.8 5.3 45.6 8.5 4.5 10.0 3.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like WXG100 PF06013.7 KII72315.1 - 6.1 6.9 12.9 1.2 9.2 1.2 4.3 3 1 0 4 4 2 0 Proteins of 100 residues with WXG Atg14 PF10186.4 KII72315.1 - 6.4 5.6 45.0 1.9 7.3 13.4 3.7 2 1 3 5 5 4 0 UV radiation resistance protein and autophagy-related subunit 14 V_ATPase_I PF01496.14 KII72315.1 - 6.7 4.4 47.6 1.3 6.7 4.2 4.1 1 1 3 4 4 4 0 V-type ATPase 116kDa subunit family Tropomyosin PF00261.15 KII72315.1 - 7.8 5.5 48.3 0.035 13.1 17.2 4.2 1 1 1 2 2 1 0 Tropomyosin AAA_13 PF13166.1 KII72315.1 - 8.2 4.7 65.2 0.099 11.0 22.7 3.4 3 1 2 5 5 4 0 AAA domain DUF812 PF05667.6 KII72315.1 - 9.4 4.6 52.9 0.021 13.3 10.1 4.4 2 1 3 5 5 5 0 Protein of unknown function (DUF812) DDE_Tnp_IS1595 PF12762.2 KII72316.1 - 0.028 14.2 0.0 0.045 13.5 0.0 1.3 1 1 0 1 1 1 0 ISXO2-like transposase domain PCI PF01399.22 KII72317.1 - 5.7e-05 23.3 0.1 0.00015 22.0 0.1 1.8 1 1 0 1 1 1 1 PCI domain HSF_DNA-bind PF00447.12 KII72318.1 - 0.052 13.7 0.4 0.075 13.1 0.2 1.3 1 1 0 1 1 1 0 HSF-type DNA-binding Kinetochor_Ybp2 PF08568.5 KII72318.1 - 0.058 11.6 0.1 0.059 11.6 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family, YAP/Alf4/glomulin MARVEL PF01284.18 KII72319.1 - 0.00032 20.5 8.3 0.00054 19.7 5.7 1.5 1 1 0 1 1 1 1 Membrane-associating domain ISK_Channel PF02060.10 KII72319.1 - 0.13 11.7 0.4 0.25 10.9 0.3 1.4 1 0 0 1 1 1 0 Slow voltage-gated potassium channel EMP24_GP25L PF01105.19 KII72321.1 - 6e-23 81.4 2.0 6.6e-23 81.3 1.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Ada_Zn_binding PF02805.11 KII72322.1 - 0.0068 15.9 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Metal binding domain of Ada zf-C2H2 PF00096.21 KII72326.1 - 1.2e-10 41.0 10.6 0.0002 21.4 0.2 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 KII72326.1 - 4.1e-08 33.1 8.1 0.00042 20.3 0.1 3.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 KII72326.1 - 5.6e-08 32.6 20.6 3e-05 24.0 0.5 5.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII72326.1 - 1.1e-07 31.6 12.8 0.00039 20.5 0.3 4.0 4 0 0 4 4 3 2 C2H2-type zinc finger zf-Di19 PF05605.7 KII72326.1 - 0.0015 18.5 3.0 1.2 9.2 0.0 2.7 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.2 KII72326.1 - 0.0019 18.3 8.6 0.037 14.2 0.1 3.8 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 KII72326.1 - 0.0089 15.9 4.1 0.077 12.9 0.1 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger DUF1644 PF07800.7 KII72326.1 - 0.014 15.2 7.1 0.021 14.6 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1644) DUF629 PF04780.7 KII72326.1 - 0.027 13.0 4.8 0.5 8.8 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_2 PF12756.2 KII72326.1 - 0.063 13.3 8.7 4 7.6 6.0 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) ARS2 PF04959.8 KII72326.1 - 0.086 13.0 2.2 0.5 10.5 0.1 2.1 1 1 1 2 2 2 0 Arsenite-resistance protein 2 DUF2180 PF09947.4 KII72326.1 - 0.16 11.7 3.1 0.62 9.8 2.1 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) zf-BED PF02892.10 KII72326.1 - 0.29 10.9 5.1 0.66 9.7 0.0 3.0 2 1 0 2 2 2 0 BED zinc finger Transpos_assoc PF13963.1 KII72326.1 - 0.49 10.4 6.1 0.37 10.8 2.4 2.1 1 1 1 2 2 2 0 Transposase-associated domain DUF2197 PF09963.4 KII72326.1 - 0.77 9.7 5.3 11 6.0 0.0 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) DDE_3 PF13358.1 KII72328.1 - 2.3e-05 24.1 0.0 3e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease Pep3_Vps18 PF05131.9 KII72329.1 - 1.4e-13 50.5 0.3 5.3e-13 48.6 0.2 2.1 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.15 KII72329.1 - 0.0001 21.9 10.8 0.029 13.9 0.6 3.9 2 2 1 3 3 3 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.1 KII72329.1 - 0.0031 17.5 1.8 0.012 15.6 1.3 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.4 KII72329.1 - 0.0033 17.5 0.4 0.0098 16.0 0.1 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-RING_2 PF13639.1 KII72329.1 - 0.0049 16.6 1.9 0.016 15.0 1.3 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KII72329.1 - 0.025 14.2 1.3 0.083 12.5 0.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CagA PF03507.8 KII72329.1 - 0.049 13.4 0.0 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 CagA exotoxin zf-RING_5 PF14634.1 KII72329.1 - 0.12 12.1 5.8 0.05 13.3 1.5 2.3 2 0 0 2 2 2 0 zinc-RING finger domain DDE_3 PF13358.1 KII72330.1 - 2e-09 37.3 0.0 2.5e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease GST_N_3 PF13417.1 KII72331.1 - 1.6e-06 28.2 0.0 3.2e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KII72331.1 - 2.3e-05 24.3 0.0 6.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 KII72331.1 - 3.8e-05 23.7 0.0 6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KII72331.1 - 0.0051 16.6 0.0 0.0073 16.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4303 PF14136.1 KII72331.1 - 0.0093 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4303) GST_C_3 PF14497.1 KII72331.1 - 0.014 15.8 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KII72331.1 - 0.026 14.5 0.0 0.061 13.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sec63 PF02889.11 KII72332.1 - 2.4e-133 444.2 6.9 3.9e-75 252.9 0.3 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 KII72332.1 - 4.3e-52 176.0 3.9 2.5e-25 88.8 0.2 3.6 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.10 KII72332.1 - 3.5e-19 69.3 6.0 1.9e-09 37.5 0.1 2.9 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 KII72332.1 - 8.8e-18 63.9 0.1 1.7e-07 31.0 0.0 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.1 KII72332.1 - 9.8e-09 35.4 1.1 0.0019 18.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 KII72332.1 - 1.9e-05 24.1 0.3 0.67 9.3 0.0 3.9 4 0 0 4 4 4 2 IstB-like ATP binding protein AAA PF00004.24 KII72332.1 - 0.00027 21.1 0.5 0.49 10.6 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 KII72332.1 - 0.00032 20.0 0.1 0.52 9.5 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein T2SE PF00437.15 KII72332.1 - 0.0011 17.8 0.0 0.093 11.6 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_10 PF12846.2 KII72332.1 - 0.034 13.5 0.3 40 3.4 0.0 3.9 2 2 0 4 4 4 0 AAA-like domain Zeta_toxin PF06414.7 KII72332.1 - 0.051 12.6 0.0 1.3 8.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Serpin PF00079.15 KII72336.1 - 2.6e-38 132.1 6.6 3e-38 131.9 4.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Kelch_6 PF13964.1 KII72337.1 - 1.4e-15 56.7 5.1 0.00013 21.9 0.3 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII72337.1 - 2e-14 53.2 0.6 0.00013 21.9 0.0 3.1 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII72337.1 - 4.6e-13 48.7 1.4 4e-05 23.2 0.2 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII72337.1 - 9.6e-10 37.8 7.4 0.0045 16.4 0.5 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII72337.1 - 1.3e-06 27.9 2.3 0.15 11.8 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII72337.1 - 5.4e-05 23.0 2.6 2.3 8.2 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Rax2 PF12768.2 KII72337.1 - 0.013 14.6 1.1 0.053 12.7 0.7 1.7 1 1 0 1 1 1 0 Cortical protein marker for cell polarity Kelch_3 PF13415.1 KII72338.1 - 3.8e-06 26.8 1.4 0.13 12.4 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII72338.1 - 1.4e-05 24.5 1.2 0.0083 15.6 0.1 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 KII72338.1 - 5.1e-05 23.2 4.9 0.96 9.7 0.1 3.5 2 1 1 3 3 3 2 Kelch motif Kelch_2 PF07646.10 KII72338.1 - 0.00077 19.1 2.6 0.4 10.5 0.0 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 KII72338.1 - 0.077 12.9 0.9 1.9 8.5 0.1 2.5 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.1 KII72338.1 - 0.2 11.4 9.4 0.26 11.0 0.5 3.2 2 1 1 3 3 3 0 Galactose oxidase, central domain Kelch_4 PF13418.1 KII72339.1 - 0.00017 21.3 0.3 0.0088 15.7 0.1 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII72339.1 - 0.0014 18.6 0.4 0.59 10.4 0.1 2.3 1 1 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII72339.1 - 0.0024 17.5 0.9 0.049 13.4 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.20 KII72339.1 - 0.015 14.8 1.3 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 Kelch motif DUF3420 PF11900.3 KII72339.1 - 0.084 12.9 0.2 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) Ldl_recept_a PF00057.13 KII72341.1 - 0.00031 20.5 7.9 0.00031 20.5 5.5 2.9 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Sigma_reg_N PF13800.1 KII72341.1 - 0.018 15.0 0.2 0.05 13.6 0.1 1.8 1 0 0 1 1 1 0 Sigma factor regulator N-terminal NPV_P10 PF05531.7 KII72342.1 - 0.00029 21.0 10.5 0.15 12.3 0.1 2.3 1 1 1 2 2 2 2 Nucleopolyhedrovirus P10 protein Chordopox_A30L PF06015.7 KII72342.1 - 0.0016 17.9 4.8 0.042 13.4 2.6 2.6 1 1 1 2 2 2 1 Chordopoxvirus A30L protein Laminin_II PF06009.7 KII72342.1 - 0.002 17.8 8.7 0.012 15.4 1.8 2.2 1 1 1 2 2 2 1 Laminin Domain II DUF1664 PF07889.7 KII72342.1 - 0.0033 17.2 10.7 0.016 15.0 1.9 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) SlyX PF04102.7 KII72342.1 - 0.0045 17.3 6.4 0.33 11.3 0.8 2.6 1 1 1 2 2 2 2 SlyX Syntaxin_2 PF14523.1 KII72342.1 - 0.0071 16.3 4.0 0.0071 16.3 2.8 2.4 1 1 1 2 2 2 1 Syntaxin-like protein Reo_sigmaC PF04582.7 KII72342.1 - 0.013 14.7 2.1 0.018 14.2 1.4 1.3 1 1 0 1 1 1 0 Reovirus sigma C capsid protein MscS_porin PF12795.2 KII72342.1 - 0.017 14.4 0.9 0.017 14.4 0.6 2.1 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain Myosin_tail_1 PF01576.14 KII72342.1 - 0.026 12.2 12.3 0.23 9.1 8.5 1.9 1 1 0 1 1 1 0 Myosin tail Laminin_I PF06008.9 KII72342.1 - 0.042 13.1 13.2 1.1 8.4 9.1 2.8 1 1 0 1 1 1 0 Laminin Domain I IFT46_B_C PF12317.3 KII72342.1 - 0.065 12.6 4.3 0.035 13.4 1.6 1.4 1 1 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal Cep57_MT_bd PF06657.8 KII72342.1 - 0.076 12.9 2.5 0.12 12.2 0.2 2.4 3 1 0 3 3 2 0 Centrosome microtubule-binding domain of Cep57 V-SNARE PF05008.10 KII72342.1 - 0.077 13.1 9.2 0.44 10.7 1.5 3.1 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF1426 PF07234.6 KII72342.1 - 0.08 12.6 0.1 2.4 7.9 0.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1426) E2R135 PF11570.3 KII72342.1 - 0.094 12.8 2.5 0.2 11.7 1.7 1.4 1 1 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 CtIP_N PF10482.4 KII72342.1 - 0.099 12.4 6.7 0.33 10.7 4.6 1.8 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain TMF_TATA_bd PF12325.3 KII72342.1 - 0.1 12.3 8.7 0.81 9.4 0.6 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding FliJ PF02050.11 KII72342.1 - 0.11 12.5 6.8 3.2 7.8 0.2 2.3 1 1 1 2 2 2 0 Flagellar FliJ protein IncA PF04156.9 KII72342.1 - 0.12 11.9 8.4 0.19 11.3 5.9 1.3 1 1 0 1 1 1 0 IncA protein PspA_IM30 PF04012.7 KII72342.1 - 0.12 11.6 3.5 0.39 10.0 2.1 1.9 1 1 0 1 1 1 0 PspA/IM30 family Corona_S2 PF01601.11 KII72342.1 - 0.13 10.3 8.2 0.0077 14.3 2.3 1.4 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein Atg14 PF10186.4 KII72342.1 - 0.13 11.2 11.5 0.42 9.5 6.0 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 TACC PF05010.9 KII72342.1 - 0.14 11.8 8.4 0.16 11.6 5.8 1.1 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) COG2 PF06148.6 KII72342.1 - 0.19 11.6 5.8 1.5 8.6 1.1 2.6 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Prefoldin_2 PF01920.15 KII72342.1 - 0.21 11.3 14.9 0.34 10.6 0.9 2.8 2 1 0 2 2 2 0 Prefoldin subunit DASH_Duo1 PF08651.5 KII72342.1 - 0.22 11.1 9.7 1.9 8.1 1.3 2.9 2 1 1 3 3 3 0 DASH complex subunit Duo1 HsbA PF12296.3 KII72342.1 - 0.25 11.1 5.5 0.51 10.2 1.9 2.3 2 1 0 2 2 2 0 Hydrophobic surface binding protein A DUF4140 PF13600.1 KII72342.1 - 0.28 11.6 3.2 2.2 8.7 0.5 2.3 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Adeno_PIX PF03955.9 KII72342.1 - 0.31 11.5 2.3 12 6.4 0.2 2.2 1 1 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Baculo_PEP_C PF04513.7 KII72342.1 - 0.37 10.6 9.1 7.5 6.3 6.3 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nsp1_C PF05064.8 KII72342.1 - 0.4 10.3 10.3 1.1 8.9 1.8 2.3 1 1 0 2 2 2 0 Nsp1-like C-terminal region TPR_MLP1_2 PF07926.7 KII72342.1 - 0.42 10.3 13.4 4.1 7.1 9.3 2.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Sas10_Utp3 PF04000.10 KII72342.1 - 0.46 10.6 3.8 19 5.5 0.1 3.1 2 1 1 3 3 3 0 Sas10/Utp3/C1D family DUF641 PF04859.7 KII72342.1 - 0.84 9.3 7.7 1.8 8.3 2.6 2.1 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) Nup54 PF13874.1 KII72342.1 - 0.91 9.1 6.6 1.5 8.5 0.3 2.2 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 MCPsignal PF00015.16 KII72342.1 - 0.92 9.0 7.6 0.48 9.9 3.1 1.7 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain BEX PF04538.7 KII72342.1 - 0.97 9.6 6.6 1.9 8.7 2.6 2.4 1 1 0 2 2 2 0 Brain expressed X-linked like family Pox_A_type_inc PF04508.7 KII72342.1 - 1.3 8.9 6.6 14 5.8 0.4 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Phage_GP20 PF06810.6 KII72342.1 - 1.5 8.2 16.5 1.3 8.4 3.4 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 Rad50_zn_hook PF04423.9 KII72342.1 - 1.5 8.3 6.3 11 5.5 0.4 3.0 2 1 1 3 3 3 0 Rad50 zinc hook motif FemAB PF02388.11 KII72342.1 - 1.6 7.3 9.4 0.089 11.4 1.1 2.0 1 1 0 2 2 2 0 FemAB family DUF948 PF06103.6 KII72342.1 - 1.6 8.6 11.4 26 4.7 3.1 3.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1313 PF07011.6 KII72342.1 - 1.9 8.2 7.3 0.38 10.4 0.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1313) MutS_IV PF05190.13 KII72342.1 - 2 8.6 8.3 5.3 7.2 0.7 2.9 2 1 1 3 3 3 0 MutS family domain IV Prefoldin PF02996.12 KII72342.1 - 2.3 7.9 11.4 2.5 7.7 0.9 2.9 1 1 3 4 4 4 0 Prefoldin subunit V_ATPase_I PF01496.14 KII72342.1 - 2.3 5.9 13.0 0.34 8.7 2.8 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.2 KII72342.1 - 2.9 7.7 11.6 28 4.5 8.0 2.0 1 1 0 1 1 1 0 Tropomyosin like DUF4407 PF14362.1 KII72342.1 - 3 6.6 6.3 6.3 5.6 4.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec2p PF06428.6 KII72342.1 - 3.1 7.6 8.0 16 5.4 0.4 2.4 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p DUF4164 PF13747.1 KII72342.1 - 4 7.6 9.5 3.3 7.8 1.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) Cortex-I_coil PF09304.5 KII72342.1 - 5.8 7.0 10.1 0.87 9.6 0.9 2.7 1 1 2 3 3 3 0 Cortexillin I, coiled coil DUF972 PF06156.8 KII72342.1 - 7.1 7.0 10.0 15 5.9 0.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Syntaxin-6_N PF09177.6 KII72342.1 - 8.6 6.8 11.2 8.8 6.8 1.6 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal zf-H2C2_2 PF13465.1 KII72344.1 - 0.0002 21.4 0.2 0.0002 21.4 0.1 3.5 3 1 0 3 3 3 2 Zinc-finger double domain zf-H2C2_5 PF13909.1 KII72344.1 - 0.00055 20.0 0.1 0.00055 20.0 0.0 4.1 3 1 1 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.1 KII72344.1 - 0.0035 17.5 14.0 1.1 9.7 1.2 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger DUF3505 PF12013.3 KII72344.1 - 0.0097 16.1 0.5 0.0097 16.1 0.4 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3505) zf-C2H2 PF00096.21 KII72344.1 - 4.6 7.7 15.7 16 6.1 0.1 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type Pap_E4 PF02711.9 KII72344.1 - 7.6 7.4 8.1 1.3 9.8 3.1 1.5 2 0 0 2 2 2 0 E4 protein Collagen PF01391.13 KII72345.1 - 2.5e-06 26.9 13.2 2.5e-06 26.9 9.2 2.0 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Serglycin PF04360.7 KII72345.1 - 0.055 13.1 3.1 0.091 12.4 2.2 1.5 1 0 0 1 1 1 0 Serglycin RRM_5 PF13893.1 KII72346.1 - 5.9e-06 26.0 0.0 1.1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 KII72346.1 - 8.5e-05 22.1 2.4 0.00015 21.3 1.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.17 KII72346.1 - 0.0001 21.8 0.0 0.00019 20.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII72346.1 - 0.025 14.5 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Tachystatin_B PF11478.3 KII72346.1 - 0.17 11.5 2.3 0.34 10.6 1.6 1.4 1 0 0 1 1 1 0 Antimicrobial chitin binding protein tachystatin B ADH_zinc_N PF00107.21 KII72347.1 - 7.2e-28 96.7 0.4 1.1e-27 96.0 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KII72347.1 - 2.4e-06 28.4 0.0 9.7e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase MTS PF05175.9 KII72347.1 - 0.0011 18.3 0.7 0.11 11.8 0.5 2.1 1 1 0 1 1 1 1 Methyltransferase small domain SCPU PF05229.10 KII72348.1 - 5.4e-05 23.2 2.1 6.7e-05 23.0 1.4 1.2 1 0 0 1 1 1 1 Spore Coat Protein U domain Fimbrial PF00419.15 KII72349.1 - 1.3e-13 51.4 2.1 1.7e-13 51.0 1.5 1.1 1 0 0 1 1 1 1 Fimbrial protein Big_5 PF13205.1 KII72349.1 - 0.049 14.2 1.6 0.13 12.8 1.1 1.7 1 1 1 2 2 2 0 Bacterial Ig-like domain Usher PF00577.15 KII72350.1 - 5.1e-142 474.4 26.6 6e-142 474.1 18.4 1.1 1 0 0 1 1 1 1 Outer membrane usher protein PapC_C PF13953.1 KII72350.1 - 7.8e-23 79.8 0.1 1.3e-21 75.9 0.0 2.5 2 0 0 2 2 2 1 PapC C-terminal domain PapD_C PF02753.12 KII72351.1 - 2.2e-15 56.2 0.6 3.3e-15 55.6 0.4 1.3 1 0 0 1 1 1 1 Pili assembly chaperone PapD, C-terminal domain PapD_N PF00345.15 KII72351.1 - 3.4e-05 23.6 0.2 0.00013 21.6 0.0 2.0 3 0 0 3 3 3 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain Mem_trans PF03547.13 KII72352.1 - 7.5e-30 103.4 37.7 3.5e-15 55.2 11.4 2.0 1 1 1 2 2 2 2 Membrane transport protein LysR_substrate PF03466.15 KII72353.1 - 5.7e-20 71.3 0.0 7.9e-20 70.8 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.22 KII72353.1 - 4.8e-13 48.6 0.3 8.3e-13 47.8 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_8 PF02954.14 KII72353.1 - 0.045 13.2 0.1 0.075 12.5 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_3 PF01381.17 KII72353.1 - 0.058 13.2 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix Bac_surface_Ag PF01103.18 KII72354.1 - 1.1e-88 297.8 16.4 1.9e-88 297.0 11.4 1.4 1 0 0 1 1 1 1 Surface antigen Surf_Ag_VNR PF07244.10 KII72354.1 - 1.1e-60 201.9 6.3 8e-15 55.0 0.3 5.6 5 0 0 5 5 5 5 Surface antigen variable number repeat POTRA_2 PF08479.6 KII72354.1 - 5.1e-06 26.0 1.0 0.71 9.5 0.0 5.2 6 0 0 6 6 6 2 POTRA domain, ShlB-type POTRA_1 PF08478.5 KII72354.1 - 1.4e-05 24.9 0.4 0.1 12.6 0.0 3.9 4 0 0 4 4 4 2 POTRA domain, FtsQ-type HTH_18 PF12833.2 KII72355.1 - 2.3e-16 59.6 0.1 3.9e-16 58.9 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.18 KII72355.1 - 1.6e-11 43.6 0.4 8e-07 28.7 0.1 2.2 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family TonB_dep_Rec PF00593.19 KII72356.1 - 2e-25 90.2 16.9 2.5e-25 89.9 11.7 1.1 1 0 0 1 1 1 1 TonB dependent receptor IBP39 PF11422.3 KII72357.1 - 0.012 15.1 3.1 1.5 8.2 0.0 2.3 1 1 0 2 2 2 0 Initiator binding protein 39 kDa Kunitz_BPTI PF00014.18 KII72359.1 - 0.00019 21.5 9.5 0.013 15.6 0.2 2.9 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF3826 PF12875.2 KII72359.1 - 0.16 11.6 0.0 0.21 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) Kunitz_BPTI PF00014.18 KII72360.1 - 1.9e-07 31.1 4.0 3.4e-05 23.9 1.0 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF4292 PF14125.1 KII72361.1 - 0.0045 16.4 0.1 0.0077 15.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4292) Peptidase_M1 PF01433.15 KII72366.1 - 2e-91 307.0 1.9 3.1e-91 306.3 1.1 1.5 2 0 0 2 2 2 1 Peptidase family M1 ERAP1_C PF11838.3 KII72366.1 - 7.1e-16 58.3 0.0 1.2e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 KII72366.1 - 1.8e-15 57.0 2.0 3.1e-15 56.3 1.4 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Meleagrin PF08189.6 KII72367.1 - 0.24 10.9 0.3 0.24 10.9 0.2 1.8 2 0 0 2 2 2 0 Meleagrin/Cygnin family EF-hand_4 PF12763.2 KII72368.1 - 9.8e-20 70.2 0.0 5.3e-09 35.7 0.0 2.6 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SH3_1 PF00018.23 KII72368.1 - 8.4e-18 63.4 2.5 1.1e-06 27.9 0.0 3.4 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.1 KII72368.1 - 1.1e-16 60.1 0.2 2.8e-08 33.2 0.0 3.0 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.12 KII72368.1 - 2.9e-13 49.0 0.1 0.001 18.5 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain EF-hand_1 PF00036.27 KII72368.1 - 3.8e-07 28.9 0.2 0.042 13.1 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KII72368.1 - 1e-06 28.7 0.0 0.028 14.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KII72368.1 - 0.0098 15.4 0.0 3.6 7.2 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KII72368.1 - 0.012 15.4 0.3 6 7.0 0.1 3.1 3 0 0 3 3 3 0 EF-hand domain AAA_34 PF13872.1 KII72369.1 - 4.1e-125 416.5 0.0 8.3e-125 415.5 0.0 1.5 2 0 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.1 KII72369.1 - 2.3e-100 335.6 0.0 3.9e-100 334.8 0.0 1.4 1 0 0 1 1 1 1 Helicase_C-like Helicase_C PF00271.26 KII72369.1 - 0.00011 21.9 0.5 0.00034 20.4 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII72369.1 - 0.0005 19.9 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Zot PF05707.7 KII72369.1 - 0.0035 16.8 0.0 0.0072 15.8 0.0 1.4 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) DEAD PF00270.24 KII72369.1 - 0.038 13.4 0.0 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase CDO_I PF05995.7 KII72370.1 - 2.1e-28 98.6 0.3 2.5e-28 98.4 0.2 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I DUF1637 PF07847.7 KII72370.1 - 5.7e-05 22.5 0.3 7.5e-05 22.1 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1637) Ribosomal_L17 PF01196.14 KII72370.1 - 0.035 14.6 0.1 0.089 13.3 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L17 NRDE-2 PF08424.5 KII72370.1 - 0.047 12.5 0.6 0.064 12.1 0.4 1.2 1 0 0 1 1 1 0 NRDE-2, necessary for RNA interference DUF3405 PF11885.3 KII72370.1 - 0.055 11.6 0.1 0.062 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) IMD PF08397.6 KII72370.1 - 0.17 11.1 2.1 0.15 11.3 0.4 1.6 2 0 0 2 2 2 0 IRSp53/MIM homology domain BRE1 PF08647.6 KII72370.1 - 1.4 8.9 9.6 3.2 7.7 1.5 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase CDO_I PF05995.7 KII72371.1 - 3.8e-27 94.5 0.1 4.9e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I Cupin_7 PF12973.2 KII72371.1 - 0.089 12.6 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 ChrR Cupin-like domain Aminotran_1_2 PF00155.16 KII72373.1 - 2.6e-34 118.7 0.0 3.1e-34 118.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KII72373.1 - 0.0055 15.8 0.0 0.0079 15.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 KII72374.1 - 8.3e-90 301.1 0.0 1e-89 300.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KII72374.1 - 2.6e-09 36.6 0.0 3.2e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KII72374.1 - 1.4e-08 34.2 0.1 2.1e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 KII72374.1 - 2.4e-07 30.0 0.0 3.9e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Pyridoxal_deC PF00282.14 KII72374.1 - 2.1e-05 23.1 0.0 4.1e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.15 KII72374.1 - 0.0011 17.3 0.0 0.0016 16.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF4325 PF14213.1 KII72374.1 - 0.042 13.5 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4325) TetR_C_8 PF14278.1 KII72375.1 - 0.0045 17.3 0.8 0.0066 16.8 0.5 1.4 1 0 0 1 1 1 1 Transcriptional regulator C-terminal region PAP_fibrillin PF04755.7 KII72375.1 - 0.075 12.7 0.2 0.09 12.4 0.1 1.1 1 0 0 1 1 1 0 PAP_fibrillin MANEC PF07502.9 KII72376.1 - 0.062 13.2 1.5 0.079 12.9 1.0 1.2 1 0 0 1 1 1 0 MANEC domain Mtp PF03821.11 KII72377.1 - 0.025 13.9 0.6 0.032 13.6 0.4 1.2 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter DUF3753 PF12575.3 KII72377.1 - 0.05 13.4 0.6 0.05 13.4 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) VIT1 PF01988.14 KII72377.1 - 0.052 13.0 0.0 0.064 12.7 0.0 1.1 1 0 0 1 1 1 0 VIT family Arrestin_C PF02752.17 KII72377.1 - 0.19 11.8 1.9 0.29 11.2 1.3 1.3 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain VIT1 PF01988.14 KII72378.1 - 0.025 14.0 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 VIT family Mtp PF03821.11 KII72378.1 - 0.029 13.7 0.6 0.035 13.4 0.4 1.2 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter DUF3753 PF12575.3 KII72378.1 - 0.031 14.0 0.7 0.071 12.9 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) DUF898 PF05987.8 KII72380.1 - 0.04 12.8 0.0 0.068 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Baculo_LEF-10 PF07206.6 KII72381.1 - 0.0031 17.1 1.1 0.0053 16.3 0.8 1.5 1 0 0 1 1 1 1 Baculovirus late expression factor 10 (LEF-10) MttA_Hcf106 PF02416.11 KII72381.1 - 0.28 10.3 3.5 0.52 9.4 2.4 1.4 1 0 0 1 1 1 0 mttA/Hcf106 family DUF3540 PF12059.3 KII72382.1 - 5e-13 49.1 21.0 0.75 9.4 0.4 7.9 1 1 2 3 3 3 2 Protein of unknown function (DUF3540) OEP PF02321.13 KII72382.1 - 0.0031 17.1 95.7 0.99 8.9 6.3 6.7 1 1 5 6 6 6 6 Outer membrane efflux protein Ribosomal_L28 PF00830.14 KII72384.1 - 0.017 14.9 1.2 0.017 14.9 0.8 2.2 2 0 0 2 2 2 0 Ribosomal L28 family RRM_2 PF04059.7 KII72384.1 - 0.18 11.8 6.4 0.094 12.7 1.0 2.7 2 2 1 3 3 3 0 RNA recognition motif 2 Ribosomal_L28 PF00830.14 KII72385.1 - 0.0041 16.9 1.5 0.0059 16.4 1.0 1.2 1 0 0 1 1 1 1 Ribosomal L28 family Corona_RPol_N PF06478.8 KII72388.1 - 0.03 13.0 0.0 0.034 12.8 0.0 1.0 1 0 0 1 1 1 0 Coronavirus RPol N-terminus BNR PF02012.15 KII72390.1 - 0.0054 16.3 4.1 2.5 8.2 0.0 3.4 4 0 0 4 4 4 2 BNR/Asp-box repeat Mo-co_dimer PF03404.11 KII72390.1 - 0.024 14.2 0.2 0.73 9.4 0.0 2.4 2 0 0 2 2 2 0 Mo-co oxidoreductase dimerisation domain DHQ_synthase PF01761.15 KII72392.1 - 0.0021 17.0 0.4 0.0038 16.1 0.3 1.4 1 1 0 1 1 1 1 3-dehydroquinate synthase SNAP PF14938.1 KII72392.1 - 0.0037 16.4 0.6 0.0051 15.9 0.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PA_decarbox PF05870.6 KII72392.1 - 0.0047 16.4 0.2 0.0079 15.6 0.1 1.4 1 1 0 1 1 1 1 Phenolic acid decarboxylase (PAD) AAA_14 PF13173.1 KII72392.1 - 0.74 9.7 3.7 0.42 10.5 1.1 1.7 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.8 KII72393.1 - 7e-102 341.1 0.1 8.3e-102 340.8 0.1 1.1 1 0 0 1 1 1 1 TIP49 C-terminus AAA_22 PF13401.1 KII72393.1 - 0.034 14.2 0.0 0.063 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.8 KII72394.1 - 5.8e-50 170.1 1.8 6.7e-50 169.9 1.3 1.1 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 KII72394.1 - 5.7e-08 33.0 0.2 9e-08 32.3 0.1 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.10 KII72394.1 - 1.1e-06 27.7 0.1 1.5e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain RuvB_N PF05496.7 KII72394.1 - 3.3e-06 26.3 0.1 3.8e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF2075 PF09848.4 KII72394.1 - 0.00018 20.6 0.0 0.00022 20.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.1 KII72394.1 - 0.00029 20.5 0.1 0.00051 19.7 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 KII72394.1 - 0.00059 19.5 0.1 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 KII72394.1 - 0.00063 19.1 0.1 0.00075 18.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KII72394.1 - 0.00087 18.4 0.3 0.0014 17.8 0.2 1.3 1 0 0 1 1 1 1 Zeta toxin Mg_chelatase PF01078.16 KII72394.1 - 0.0012 18.0 0.3 0.0017 17.5 0.2 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI KaiC PF06745.8 KII72394.1 - 0.0015 17.6 1.5 0.0022 17.1 0.9 1.5 1 1 0 1 1 1 1 KaiC AAA_22 PF13401.1 KII72394.1 - 0.0028 17.8 0.1 0.0042 17.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 KII72394.1 - 0.0048 16.5 0.1 0.0067 16.0 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_32 PF13654.1 KII72394.1 - 0.005 15.5 0.2 0.0066 15.1 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KII72394.1 - 0.0067 16.7 0.2 0.0095 16.2 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII72394.1 - 0.0097 15.9 0.1 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.12 KII72394.1 - 0.012 15.0 0.1 0.015 14.7 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.1 KII72394.1 - 0.015 14.9 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 KII72394.1 - 0.016 14.8 0.3 0.022 14.3 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_17 PF13207.1 KII72394.1 - 0.016 16.0 0.1 0.023 15.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KII72394.1 - 0.041 13.3 0.1 0.055 12.9 0.1 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.1 KII72394.1 - 0.057 13.2 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KII72394.1 - 0.078 12.2 0.6 0.13 11.4 0.4 1.4 1 0 0 1 1 1 0 PhoH-like protein FtsK_SpoIIIE PF01580.13 KII72394.1 - 0.081 12.3 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Parvo_NS1 PF01057.12 KII72394.1 - 0.083 11.7 0.2 0.1 11.4 0.1 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.17 KII72394.1 - 0.083 13.0 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase GvpD PF07088.6 KII72394.1 - 0.098 10.9 0.2 0.16 10.2 0.2 1.3 1 0 0 1 1 1 0 GvpD gas vesicle protein AAA_30 PF13604.1 KII72394.1 - 0.11 12.1 0.6 0.14 11.7 0.4 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KII72394.1 - 0.15 11.9 0.2 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 KII72394.1 - 0.16 11.7 0.6 0.22 11.3 0.4 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF1479 PF07350.7 KII72395.1 - 0.021 13.3 0.1 0.023 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) FLYWCH PF04500.11 KII72395.1 - 0.041 13.7 0.2 0.061 13.2 0.1 1.3 1 0 0 1 1 1 0 FLYWCH zinc finger domain HSP70 PF00012.15 KII72396.1 - 3.6e-74 249.7 0.0 4.5e-74 249.4 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KII72396.1 - 1.9e-11 43.1 0.0 8.2e-11 41.0 0.0 1.9 2 1 0 2 2 2 1 MreB/Mbl protein DDR PF08841.5 KII72396.1 - 0.0056 15.5 0.1 0.068 11.9 0.0 2.0 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.1 KII72396.1 - 0.023 14.5 0.5 0.43 10.4 0.0 2.8 2 1 0 2 2 2 0 Cell division protein FtsA Hydantoinase_A PF01968.13 KII72396.1 - 0.024 13.7 0.0 0.048 12.7 0.0 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase StbA PF06406.6 KII72396.1 - 0.037 12.9 0.1 0.11 11.3 0.1 1.7 1 1 0 1 1 1 0 StbA protein DUF1726 PF08351.6 KII72397.1 - 0.075 12.7 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1726) Serpin PF00079.15 KII72401.1 - 5.2e-25 88.3 3.7 5.5e-25 88.2 2.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ribosomal_L1 PF00687.16 KII72402.1 - 5.4e-48 163.2 5.9 6.5e-48 162.9 4.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Serpin PF00079.15 KII72403.1 - 2.8e-32 112.2 0.0 3e-32 112.1 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_Tnp_IS1595 PF12762.2 KII72407.1 - 2.7e-07 30.5 0.0 5.1e-07 29.6 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain Exo_endo_phos PF03372.18 KII72409.1 - 2.1e-21 77.0 0.0 3.1e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.22 KII72409.1 - 0.0002 21.0 1.1 0.0012 18.4 0.2 2.6 2 1 0 2 2 2 1 RhoGAP domain PHD PF00628.24 KII72410.1 - 4.4e-06 26.2 9.9 4.4e-06 26.2 6.9 4.1 4 1 0 4 4 4 1 PHD-finger zf-NF-X1 PF01422.12 KII72410.1 - 6e-05 22.9 16.2 6e-05 22.9 11.2 4.8 4 1 1 5 5 5 2 NF-X1 type zinc finger Prok-RING_1 PF14446.1 KII72410.1 - 0.00012 21.7 2.7 0.00012 21.7 1.9 4.4 3 3 0 3 3 3 1 Prokaryotic RING finger family 1 Homeobox PF00046.24 KII72412.1 - 1.7e-19 69.1 8.5 3.2e-19 68.2 5.9 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KII72412.1 - 0.0083 15.8 0.5 0.02 14.6 0.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.3 KII72412.1 - 0.038 13.0 0.8 0.068 12.2 0.2 1.7 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Claudin_2 PF13903.1 KII72413.1 - 0.00038 20.1 9.1 0.0016 18.1 6.3 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Elf1 PF05129.8 KII72414.1 - 0.051 13.2 0.1 0.069 12.8 0.1 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like NMT_C PF02799.10 KII72416.1 - 8.2e-19 67.7 0.7 9.9e-19 67.4 0.5 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.14 KII72417.1 - 8.6e-46 155.5 0.0 1e-45 155.2 0.0 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.1 KII72417.1 - 6.5e-05 22.7 0.0 8.4e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PBP1_TM PF14812.1 KII72418.1 - 0.057 13.7 6.6 0.13 12.6 4.6 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sigma70_ner PF04546.8 KII72418.1 - 0.28 10.7 2.8 0.41 10.2 1.9 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Nucleoplasmin PF03066.10 KII72418.1 - 0.34 10.4 4.0 0.46 9.9 2.8 1.3 1 0 0 1 1 1 0 Nucleoplasmin Homeobox PF00046.24 KII72421.1 - 7.2e-20 70.3 3.6 1.5e-19 69.3 2.5 1.6 1 0 0 1 1 1 1 Homeobox domain Annexin PF00191.15 KII72422.1 - 9.7e-10 38.2 2.3 0.00031 20.5 0.1 3.5 4 0 0 4 4 4 2 Annexin DUF1647 PF07801.6 KII72422.1 - 0.19 11.2 0.1 0.19 11.2 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1647) Annexin PF00191.15 KII72424.1 - 0.00056 19.7 0.3 0.0014 18.4 0.2 1.7 1 0 0 1 1 1 1 Annexin Annexin PF00191.15 KII72425.1 - 6.2e-10 38.8 1.8 8.7e-05 22.3 0.1 2.2 2 0 0 2 2 2 2 Annexin GDE_C PF06202.9 KII72425.1 - 0.076 11.7 0.0 0.095 11.4 0.0 1.1 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Exo_endo_phos PF03372.18 KII72426.1 - 1e-21 78.0 0.0 1.2e-21 77.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cpn60_TCP1 PF00118.19 KII72429.1 - 2.8e-116 389.0 9.8 3.2e-116 388.8 6.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family La PF05383.12 KII72430.1 - 2.8e-17 62.2 0.8 5.3e-17 61.3 0.5 1.5 1 0 0 1 1 1 1 La domain OppC_N PF12911.2 KII72432.1 - 0.2 11.0 1.5 0.36 10.2 1.0 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C tRNA_int_endo PF01974.12 KII72433.1 - 0.00027 20.6 1.1 0.0004 20.1 0.7 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain DUF1647 PF07801.6 KII72433.1 - 0.0018 17.7 1.4 0.0024 17.3 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) tRNA_int_endo_N PF02778.9 KII72433.1 - 0.0077 15.7 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain SRP1_TIP1 PF00660.12 KII72434.1 - 0.074 12.8 1.2 1.3 8.8 0.3 3.1 2 1 1 3 3 3 0 Seripauperin and TIP1 family OSTMP1 PF09777.4 KII72435.1 - 0.049 12.8 0.3 0.049 12.8 0.2 2.1 1 1 1 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor DUF4064 PF13273.1 KII72435.1 - 6.2 6.9 11.3 0.95 9.6 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) MFS_1 PF07690.11 KII72436.1 - 4.8e-31 107.7 28.3 1.8e-26 92.6 17.6 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF3040 PF11239.3 KII72436.1 - 0.22 11.6 0.6 13 5.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) TRAP_beta PF05753.9 KII72438.1 - 0.014 14.5 0.3 0.084 12.0 0.0 2.1 2 0 0 2 2 2 0 Translocon-associated protein beta (TRAPB) DUF1129 PF06570.6 KII72440.1 - 0.011 15.0 0.2 0.55 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Phage_GPO PF05929.6 KII72441.1 - 0.17 11.1 3.1 0.22 10.7 0.2 2.4 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF1656 PF07869.7 KII72442.1 - 0.017 14.9 3.6 3.4 7.5 0.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1656) RVT_1 PF00078.22 KII72443.1 - 0.0017 17.7 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3878 PF12994.2 KII72444.1 - 0.02 14.0 0.0 0.024 13.8 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3878) Uso1_p115_head PF04869.9 KII72444.1 - 0.073 11.8 0.4 0.074 11.8 0.3 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region RST PF12174.3 KII72444.1 - 0.14 11.9 0.5 0.3 10.9 0.4 1.5 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain Kunitz_BPTI PF00014.18 KII72445.1 - 0.0073 16.4 9.9 0.0088 16.2 2.8 2.6 2 2 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain PAN_3 PF08277.7 KII72445.1 - 1.1 8.9 0.0 1.1 8.9 0.0 2.7 2 1 1 3 3 3 0 PAN-like domain WD40 PF00400.27 KII72446.1 - 5.9e-34 114.7 13.5 7.3e-10 38.3 0.1 5.8 7 0 0 7 7 7 5 WD domain, G-beta repeat BBS2_Mid PF14783.1 KII72446.1 - 0.00033 20.4 0.0 0.5 10.1 0.0 3.4 2 2 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.6 KII72446.1 - 0.06 12.0 3.0 1.4 7.5 0.4 3.2 1 1 0 2 2 2 0 Nup133 N terminal like Ribosomal_L37 PF08561.5 KII72447.1 - 1.2e-09 37.6 0.7 1.8e-09 37.0 0.5 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 Pro_isomerase PF00160.16 KII72448.1 - 1.9e-28 99.6 0.3 2.1e-28 99.4 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MCM_N PF14551.1 KII72451.1 - 0.082 13.3 6.6 2.7 8.4 0.2 4.0 2 2 1 3 3 3 0 MCM N-terminal domain Aminotran_1_2 PF00155.16 KII72452.1 - 1.8e-25 89.7 0.0 2.4e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II zf-UBR PF02207.15 KII72453.1 - 5.7e-16 58.0 19.2 5.7e-16 58.0 13.3 3.6 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) ELL PF10390.4 KII72453.1 - 0.033 13.4 0.1 0.082 12.1 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL Stc1 PF12898.2 KII72454.1 - 0.12 12.4 1.1 0.17 11.9 0.8 1.3 1 0 0 1 1 1 0 Stc1 domain IP_trans PF02121.13 KII72455.1 - 2.6e-36 125.0 0.1 3.1e-36 124.8 0.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Alg14 PF08660.6 KII72459.1 - 3.4e-52 176.8 0.2 3.8e-52 176.7 0.1 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like zf-C2H2 PF00096.21 KII72460.1 - 8.1e-14 51.0 25.0 2.7e-05 24.2 2.1 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KII72460.1 - 1.3e-11 44.1 8.4 4.8e-09 36.0 1.6 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII72460.1 - 1.3e-07 31.3 24.0 0.00032 20.8 1.1 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KII72460.1 - 0.022 14.6 1.3 0.022 14.6 0.9 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-RING_4 PF14570.1 KII72460.1 - 0.06 12.9 0.7 0.06 12.9 0.5 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-CHY PF05495.7 KII72460.1 - 0.09 12.9 8.4 0.45 10.6 0.1 2.3 1 1 1 2 2 2 0 CHY zinc finger Churchill PF06573.6 KII72460.1 - 0.14 12.1 1.5 0.27 11.2 1.1 1.5 1 1 0 1 1 1 0 Churchill protein zf-met PF12874.2 KII72460.1 - 0.73 10.1 11.5 0.69 10.2 0.7 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DDE_Tnp_IS1595 PF12762.2 KII72462.1 - 5.6e-05 23.0 0.0 8.5e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain COX4 PF02936.9 KII72463.1 - 0.0054 16.4 0.1 0.0094 15.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV ABC_sub_bind PF04392.7 KII72465.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.1 1 0 0 1 1 1 0 ABC transporter substrate binding protein DDE_Tnp_IS1595 PF12762.2 KII72467.1 - 0.0077 16.0 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Tox-HNH-HHH PF15637.1 KII72467.1 - 0.071 12.9 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif Ribosomal_L22 PF00237.14 KII72468.1 - 1.4e-30 105.2 0.2 1.8e-30 105.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e FAD_binding_1 PF00667.15 KII72469.1 - 4.2e-31 108.0 0.1 6.3e-31 107.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 KII72469.1 - 9.7e-22 77.5 0.0 1.7e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 KII72469.1 - 2.9e-08 34.2 0.0 1.1e-07 32.4 0.0 2.0 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 KII72469.1 - 0.025 14.5 0.0 0.92 9.4 0.0 2.4 1 1 1 2 2 2 0 Flavodoxin domain Flavodoxin_3 PF12641.2 KII72469.1 - 0.053 12.9 0.0 0.77 9.1 0.0 2.2 2 0 0 2 2 2 0 Flavodoxin domain PRA1 PF03208.14 KII72471.1 - 0.0052 16.1 0.4 0.0082 15.4 0.3 1.2 1 0 0 1 1 1 1 PRA1 family protein LUC7 PF03194.10 KII72473.1 - 3.4e-30 105.4 0.1 1.2e-19 70.8 0.0 2.0 1 1 1 2 2 2 2 LUC7 N_terminus CybS PF05328.7 KII72473.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 CybS GNT-I PF03071.10 KII72474.1 - 4.4e-30 104.5 0.6 6.8e-30 103.9 0.4 1.4 1 1 0 1 1 1 1 GNT-I family MGAT2 PF05060.9 KII72474.1 - 0.0032 16.4 0.1 0.0039 16.1 0.1 1.1 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) Glyco_transf_25 PF01755.12 KII72474.1 - 0.048 13.3 0.8 0.29 10.7 0.2 2.2 2 1 0 2 2 2 0 Glycosyltransferase family 25 (LPS biosynthesis protein) NAC PF01849.13 KII72475.1 - 0.002 17.5 0.1 0.012 15.0 0.0 2.1 1 1 1 2 2 2 1 NAC domain DDE_3 PF13358.1 KII72477.1 - 0.0081 15.9 0.0 0.1 12.3 0.0 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease GNT-I PF03071.10 KII72478.1 - 2.2e-14 52.8 1.6 8.3e-14 50.9 1.1 1.8 1 1 0 1 1 1 1 GNT-I family Glyco_transf_25 PF01755.12 KII72478.1 - 0.0013 18.3 2.9 0.0044 16.6 0.8 2.1 2 0 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) NAC PF01849.13 KII72478.1 - 0.0049 16.3 0.1 0.023 14.1 0.0 2.1 1 1 1 2 2 2 1 NAC domain GNT-I PF03071.10 KII72479.1 - 1e-34 119.8 0.6 5.5e-34 117.4 0.3 1.9 1 1 0 1 1 1 1 GNT-I family MGAT2 PF05060.9 KII72479.1 - 0.00013 21.0 0.0 0.083 11.7 0.0 2.1 2 0 0 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) Glyco_transf_25 PF01755.12 KII72479.1 - 0.018 14.6 0.1 0.032 13.8 0.1 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) MutL PF13941.1 KII72480.1 - 0.088 11.1 0.0 0.11 10.8 0.0 1.2 1 0 0 1 1 1 0 MutL protein GNT-I PF03071.10 KII72482.1 - 7.4e-30 103.8 1.3 1.2e-29 103.1 0.9 1.4 1 1 0 1 1 1 1 GNT-I family MGAT2 PF05060.9 KII72482.1 - 0.00042 19.3 0.3 0.00058 18.8 0.2 1.2 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) Glyco_transf_25 PF01755.12 KII72482.1 - 0.00047 19.8 1.6 0.0018 17.9 0.5 2.1 2 0 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) DUF106 PF01956.11 KII72485.1 - 0.23 10.9 1.5 0.38 10.2 1.1 1.4 1 0 0 1 1 1 0 Integral membrane protein DUF106 DDE_3 PF13358.1 KII72487.1 - 1.5e-13 50.6 0.0 2.1e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1758 PF05585.7 KII72490.1 - 0.0074 15.8 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Ub-RnfH PF03658.9 KII72491.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.5 2 0 0 2 2 2 0 RnfH family Ubiquitin Mmp37 PF09139.6 KII72492.1 - 1.8e-72 244.1 0.5 2.3e-72 243.8 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 IATP PF04568.7 KII72495.1 - 0.023 14.7 3.1 0.039 13.9 2.1 1.4 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Inhibitor_I53 PF11714.3 KII72495.1 - 0.074 13.0 1.7 0.098 12.6 0.1 2.0 1 1 0 2 2 2 0 Thrombin inhibitor Madanin DDE_3 PF13358.1 KII72496.1 - 9.5e-22 77.3 0.2 1.1e-21 77.1 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease XFP PF03894.10 KII72496.1 - 0.0065 16.0 0.1 0.0077 15.8 0.1 1.2 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase DDE_Tnp_ISAZ013 PF07592.6 KII72496.1 - 0.022 13.5 0.1 0.025 13.3 0.0 1.1 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain ITAM_Cys-rich PF10538.4 KII72496.1 - 0.036 13.6 0.3 0.064 12.8 0.2 1.4 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif Adap_comp_sub PF00928.16 KII72496.1 - 0.074 12.1 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Adaptor complexes medium subunit family Peroxin-22 PF12827.2 KII72497.1 - 0.046 13.4 0.6 0.065 12.9 0.4 1.4 1 1 0 1 1 1 0 Peroxisomal biogenesis protein family Plus-3 PF03126.13 KII72497.1 - 0.084 12.9 1.8 0.22 11.5 0.2 2.3 2 1 0 2 2 2 0 Plus-3 domain YniB PF14002.1 KII72497.1 - 0.15 11.5 1.0 2.6 7.4 0.1 2.4 2 1 0 2 2 2 0 YniB-like protein DUF4371 PF14291.1 KII72497.1 - 0.16 11.4 2.6 1.6 8.2 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4371) DUF1090 PF06476.7 KII72497.1 - 0.93 9.1 7.5 0.29 10.8 2.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1090) DDE_3 PF13358.1 KII72498.1 - 7.5e-05 22.5 0.0 9e-05 22.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease PS_Dcarbxylase PF02666.10 KII72499.1 - 2.1e-34 118.6 0.1 2.9e-34 118.1 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase DUF3794 PF12673.2 KII72499.1 - 0.15 12.2 1.6 3.6 7.8 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3794) RabGAP-TBC PF00566.13 KII72500.1 - 5.1e-22 78.4 11.9 8.3e-22 77.7 8.3 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ribosomal_L7Ae PF01248.21 KII72501.1 - 1.8e-18 65.7 0.0 2.2e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Rad51 PF08423.6 KII72503.1 - 1.1e-19 70.3 0.0 1.2e-19 70.2 0.0 1.0 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 KII72503.1 - 4.6e-09 35.9 0.0 6.9e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 KII72503.1 - 8e-07 28.4 0.1 1.6e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 KaiC RecA PF00154.16 KII72503.1 - 1.6e-06 27.4 0.1 1.4e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 recA bacterial DNA recombination protein AAA_22 PF13401.1 KII72503.1 - 3.5e-05 23.9 0.2 7.3e-05 22.9 0.2 1.6 1 1 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 KII72503.1 - 5.9e-05 22.8 0.3 8.6e-05 22.2 0.2 1.2 1 0 0 1 1 1 1 Bacterial dnaA protein NACHT PF05729.7 KII72503.1 - 0.00018 21.1 0.0 0.00025 20.7 0.0 1.2 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.17 KII72503.1 - 0.0065 16.6 0.2 0.018 15.2 0.1 1.8 1 1 0 1 1 1 1 RNA helicase DEAD PF00270.24 KII72503.1 - 0.0068 15.9 0.8 0.23 10.9 0.6 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase ABC_tran PF00005.22 KII72503.1 - 0.015 15.5 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.11 KII72503.1 - 0.018 14.2 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Arch_ATPase PF01637.13 KII72503.1 - 0.019 14.6 0.5 0.043 13.5 0.3 1.8 1 1 0 1 1 1 0 Archaeal ATPase AAA_19 PF13245.1 KII72503.1 - 0.022 14.4 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain AAA_23 PF13476.1 KII72503.1 - 0.027 14.7 0.5 0.59 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 KII72503.1 - 0.028 13.4 0.0 0.029 13.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 KII72503.1 - 0.029 14.5 0.1 0.045 13.9 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 KII72503.1 - 0.037 13.9 0.3 0.054 13.3 0.2 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 KII72503.1 - 0.072 12.5 0.0 0.092 12.1 0.0 1.4 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_24 PF13479.1 KII72503.1 - 0.075 12.6 0.1 0.16 11.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KII72503.1 - 0.076 13.8 0.1 0.11 13.2 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KII72503.1 - 0.077 12.9 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain UPF0079 PF02367.12 KII72503.1 - 0.087 12.4 0.1 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 IstB_IS21 PF01695.12 KII72503.1 - 0.1 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Vac14_Fab1_bd PF12755.2 KII72507.1 - 5.6 7.4 8.7 2.9 8.3 0.1 3.2 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region PDDEXK_4 PF14281.1 KII72509.1 - 0.0022 17.8 0.7 0.0028 17.5 0.5 1.2 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily BNR PF02012.15 KII72511.1 - 0.00036 19.9 2.8 0.8 9.7 0.1 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat STT3 PF02516.9 KII72513.1 - 1.2e-83 281.7 33.1 1.8e-83 281.1 23.0 1.1 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.1 KII72513.1 - 0.00022 21.1 17.2 0.00022 21.1 11.9 3.6 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Carboxyl_trans PF01039.17 KII72514.1 - 2.8e-63 214.0 0.7 3e-63 213.8 0.5 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 KII72514.1 - 0.008 15.4 0.0 0.0082 15.3 0.0 1.1 1 0 0 1 1 1 1 Malonate decarboxylase gamma subunit (MdcE) DUF2404 PF10296.4 KII72515.1 - 1.1e-18 67.1 0.0 2.3e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) DcuC PF03606.10 KII72515.1 - 0.0037 15.5 2.8 0.0057 14.9 1.9 1.2 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier PH PF00169.24 KII72515.1 - 0.012 15.8 0.1 0.032 14.4 0.1 1.8 1 0 0 1 1 1 0 PH domain RRM_1 PF00076.17 KII72516.1 - 1.3e-12 47.1 0.1 2.5e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII72516.1 - 1e-09 38.2 0.1 2.1e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII72516.1 - 2.7e-07 30.3 0.3 5.3e-07 29.3 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PDZ PF00595.19 KII72517.1 - 4.8e-10 39.4 0.7 7.7e-10 38.8 0.5 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII72517.1 - 0.051 13.4 0.2 0.092 12.6 0.1 1.5 1 0 0 1 1 1 0 PDZ domain DUF2937 PF11157.3 KII72518.1 - 2.1 7.6 1.5 4 6.7 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) ATG11 PF10377.4 KII72520.1 - 0.088 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 11 RPAP3_C PF13877.1 KII72526.1 - 0.015 15.2 0.1 0.031 14.2 0.1 1.5 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 zf-Sec23_Sec24 PF04810.10 KII72526.1 - 0.032 13.7 0.2 0.032 13.7 0.2 2.7 4 0 0 4 4 4 0 Sec23/Sec24 zinc finger zf-H2C2_2 PF13465.1 KII72527.1 - 2e-15 56.2 23.0 2.3e-09 37.0 0.3 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.21 KII72527.1 - 5.3e-13 48.4 22.4 6.4e-06 26.2 2.2 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII72527.1 - 6.4e-12 44.9 20.2 1.1e-05 25.4 1.2 3.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII72527.1 - 7.4e-06 25.9 8.6 0.013 15.6 0.1 3.4 3 1 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KII72527.1 - 9e-05 22.5 8.1 0.00015 21.8 0.3 3.8 3 1 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 KII72527.1 - 0.0015 18.3 1.1 0.0015 18.3 0.7 3.0 3 0 0 3 3 2 1 C2H2-type zinc finger RRN7 PF11781.3 KII72527.1 - 0.0026 17.2 2.9 0.25 10.8 0.1 2.5 2 0 0 2 2 2 2 RNA polymerase I-specific transcription initiation factor Rrn7 zf-Di19 PF05605.7 KII72527.1 - 0.034 14.2 5.2 0.12 12.5 1.5 2.7 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding SBF2 PF12335.3 KII72527.1 - 0.063 12.5 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Myotubularin protein zf-BED PF02892.10 KII72527.1 - 0.069 12.9 6.4 3.6 7.4 0.4 2.6 1 1 1 2 2 2 0 BED zinc finger GAGA PF09237.6 KII72527.1 - 0.38 10.3 3.2 0.81 9.3 0.0 2.6 1 1 2 3 3 3 0 GAGA factor zf-CHY PF05495.7 KII72527.1 - 0.49 10.5 8.7 0.52 10.5 3.7 2.3 1 1 1 2 2 2 0 CHY zinc finger zf-CHCC PF10276.4 KII72527.1 - 0.91 9.4 5.1 0.35 10.7 0.4 2.5 3 0 0 3 3 3 0 Zinc-finger domain IBR PF01485.16 KII72527.1 - 1.1 9.1 5.2 3.3 7.6 3.1 2.2 1 1 0 1 1 1 0 IBR domain zf-C2H2_2 PF12756.2 KII72527.1 - 6 7.0 11.1 4.4 7.4 1.2 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Ribosomal_L30 PF00327.15 KII72529.1 - 8.6e-10 38.0 0.7 1.5e-09 37.2 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Pro_isomerase PF00160.16 KII72530.1 - 2.8e-40 138.0 0.0 3.4e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_M16_C PF05193.16 KII72531.1 - 1.1e-13 51.3 0.3 1.5e-11 44.3 0.1 3.0 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KII72531.1 - 3.2e-11 43.1 0.0 3.6e-09 36.5 0.0 2.7 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) SNARE PF05739.14 KII72532.1 - 9.8e-05 21.9 2.2 9.8e-05 21.9 1.5 2.9 3 1 0 3 3 3 1 SNARE domain Snapin_Pallidin PF14712.1 KII72532.1 - 0.097 12.9 9.1 0.29 11.4 0.1 2.7 2 1 0 2 2 2 0 Snapin/Pallidin V-SNARE_C PF12352.3 KII72532.1 - 0.35 10.9 5.3 0.39 10.8 0.9 2.7 2 1 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 KII72532.1 - 0.4 10.4 3.1 3.8 7.2 0.2 2.4 2 1 0 2 2 2 0 Sec20 ALMT PF11744.3 KII72532.1 - 1.2 7.7 6.9 0.84 8.2 1.8 1.9 1 1 1 2 2 2 0 Aluminium activated malate transporter BLOC1_2 PF10046.4 KII72532.1 - 1.3 9.2 7.0 2.3 8.3 0.3 2.6 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YebO PF13974.1 KII72532.1 - 2.8 7.7 6.3 6.3 6.6 0.3 2.8 2 1 0 2 2 2 0 YebO-like protein DUF1664 PF07889.7 KII72532.1 - 4.9 6.9 7.1 13 5.5 0.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.6 KII72532.1 - 5.9 7.3 7.7 1.3 9.4 1.5 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4140 PF13600.1 KII72532.1 - 6.8 7.1 7.9 0.83 10.1 1.6 2.2 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Laminin_II PF06009.7 KII72532.1 - 6.9 6.4 10.5 8.3 6.1 1.0 2.5 2 1 0 2 2 2 0 Laminin Domain II DUF16 PF01519.11 KII72532.1 - 7.5 6.8 11.6 0.94 9.7 1.7 2.4 2 1 0 2 2 2 0 Protein of unknown function DUF16 Shisa PF13908.1 KII72533.1 - 9.2e-06 25.9 1.1 1.1e-05 25.7 0.8 1.0 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Pox_P21 PF05313.7 KII72533.1 - 0.049 12.8 1.0 0.062 12.5 0.7 1.1 1 0 0 1 1 1 0 Poxvirus P21 membrane protein LHC PF00556.15 KII72533.1 - 1 9.2 3.0 1.4 8.7 2.1 1.2 1 0 0 1 1 1 0 Antenna complex alpha/beta subunit Integrin_beta PF00362.13 KII72534.1 - 0.00072 18.5 0.0 0.00073 18.5 0.0 1.0 1 0 0 1 1 1 1 Integrin, beta chain EGF_2 PF07974.8 KII72535.1 - 2.2e-05 24.5 69.5 0.00097 19.2 9.8 4.7 2 1 1 3 3 3 2 EGF-like domain SNAP PF14938.1 KII72536.1 - 3.3e-06 26.4 0.2 4.2e-06 26.1 0.2 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII72536.1 - 0.011 15.6 1.7 0.22 11.5 0.4 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII72536.1 - 0.013 15.1 0.8 0.25 10.9 0.0 2.4 1 1 1 2 2 2 0 TPR repeat ATP-cone PF03477.11 KII72536.1 - 0.096 13.1 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 ATP cone domain DUF2847 PF11009.3 KII72536.1 - 0.1 12.1 0.7 0.7 9.5 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2847) TPR_2 PF07719.12 KII72536.1 - 0.7 9.9 4.8 32 4.7 0.1 3.6 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII72536.1 - 1.6 8.6 5.3 17 5.4 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DDE_Tnp_IS1595 PF12762.2 KII72540.1 - 3.3e-09 36.7 0.2 5.4e-08 32.8 0.1 2.4 1 1 0 1 1 1 1 ISXO2-like transposase domain SNAP PF14938.1 KII72541.1 - 3.6e-13 49.3 3.6 4.8e-13 48.9 2.5 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII72541.1 - 0.011 15.6 3.6 0.44 10.5 0.0 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII72541.1 - 0.011 15.3 2.3 1 9.0 0.2 2.6 2 0 0 2 2 2 0 TPR repeat CBM_10 PF02013.11 KII72541.1 - 0.052 13.8 2.4 6.1 7.2 0.0 2.5 2 0 0 2 2 2 0 Cellulose or protein binding domain TPR_7 PF13176.1 KII72541.1 - 0.053 13.3 4.0 4.2 7.4 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII72541.1 - 0.55 10.1 10.9 2 8.3 0.2 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII72541.1 - 1.1 9.3 9.8 0.34 10.9 1.4 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2786 PF10979.3 KII72541.1 - 1.4 8.6 5.5 16 5.3 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) RVP PF00077.15 KII72542.1 - 1.1e-05 25.3 0.0 2.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII72542.1 - 0.072 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease EGF_2 PF07974.8 KII72543.1 - 8.7e-09 35.3 35.6 1.5e-05 25.0 11.2 2.9 2 0 0 2 2 2 2 EGF-like domain Integrin_beta PF00362.13 KII72544.1 - 1.9e-16 60.0 0.1 1.3e-09 37.5 0.0 2.0 1 1 1 2 2 2 2 Integrin, beta chain PSI PF01437.20 KII72544.1 - 0.21 11.7 1.0 0.3 11.2 0.3 1.6 2 0 0 2 2 2 0 Plexin repeat EGF_2 PF07974.8 KII72546.1 - 3.8e-08 33.3 62.1 0.00095 19.2 9.8 4.3 4 0 0 4 4 4 3 EGF-like domain AdoMet_Synthase PF01941.14 KII72546.1 - 0.15 10.5 0.1 0.21 10.0 0.1 1.1 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) rve PF00665.21 KII72548.1 - 3.8e-05 23.7 0.0 5.1e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain SH PF01445.12 KII72549.1 - 0.11 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Viral small hydrophobic protein PA28_alpha PF02251.13 KII72551.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit O-antigen_lig PF13425.1 KII72551.1 - 0.15 12.0 4.1 0.14 12.1 1.5 1.8 2 0 0 2 2 2 0 O-antigen ligase like membrane protein OAS1_C PF10421.4 KII72552.1 - 0.016 14.7 0.1 0.074 12.5 0.0 1.9 2 0 0 2 2 2 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus DUF1989 PF09347.5 KII72553.1 - 1e-05 25.0 5.2 1.9 7.9 0.1 4.2 1 1 4 5 5 5 5 Domain of unknown function (DUF1989) VirArc_Nuclease PF12187.3 KII72553.1 - 2e-05 24.0 1.2 36 3.6 0.0 5.9 1 1 7 8 8 8 0 Viral/Archaeal nuclease NosD PF05048.8 KII72553.1 - 0.0018 17.4 0.0 0.003 16.7 0.0 1.4 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) DUF3927 PF13064.1 KII72553.1 - 1.8 8.1 14.0 3.8e+02 0.6 0.0 7.7 9 0 0 9 9 9 0 Protein of unknown function (DUF3927) MRP-63 PF14978.1 KII72553.1 - 6.7 7.2 12.6 1.3e+02 3.0 0.1 4.7 1 1 7 8 8 8 0 Mitochondrial ribosome protein 63 SRP54_N PF02881.14 KII72554.1 - 0.041 14.0 0.0 0.073 13.1 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, helical bundle domain Peptidase_M30 PF10460.4 KII72554.1 - 0.055 12.3 0.0 0.071 11.9 0.0 1.1 1 0 0 1 1 1 0 Peptidase M30 rve PF00665.21 KII72556.1 - 4.7e-29 100.9 0.0 1.4e-28 99.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII72556.1 - 9.5e-21 74.1 0.1 2.2e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII72556.1 - 3.9e-08 33.1 0.0 1.2e-07 31.5 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.5 KII72556.1 - 3.6e-06 26.2 1.2 9.7e-06 24.9 0.8 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger zf-CCHC PF00098.18 KII72556.1 - 0.0001 22.0 11.8 0.0055 16.5 1.9 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII72556.1 - 0.00053 20.4 0.0 0.0015 19.0 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII72556.1 - 0.0014 18.2 0.1 0.0037 16.8 0.1 1.7 1 1 0 1 1 1 1 Aspartyl protease rve_3 PF13683.1 KII72556.1 - 0.0026 17.2 0.0 0.0088 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-CCHC_3 PF13917.1 KII72556.1 - 0.01 15.5 5.6 0.033 13.9 0.3 2.5 1 1 1 2 2 2 1 Zinc knuckle Herpes_UL14 PF03580.9 KII72556.1 - 0.053 13.3 0.1 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL14-like protein gag-asp_proteas PF13975.1 KII72556.1 - 0.06 13.1 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII72556.1 - 0.086 12.7 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-ribbon_3 PF13248.1 KII72556.1 - 0.18 11.0 4.0 0.4 9.9 2.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-CCHC_4 PF14392.1 KII72556.1 - 7 6.3 12.1 0.35 10.5 0.6 3.2 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_5 PF14787.1 KII72556.1 - 8.1 6.0 14.0 0.36 10.3 0.7 3.2 2 1 1 3 3 3 0 GAG-polyprotein viral zinc-finger rve PF00665.21 KII72557.1 - 1.3e-14 54.2 0.0 3.6e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72557.1 - 0.011 15.2 0.0 0.024 14.1 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Baculo_PEP_C PF04513.7 KII72558.1 - 8.1e-06 25.7 0.9 1e-05 25.3 0.6 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Flp_Fap PF04964.9 KII72558.1 - 0.076 12.6 1.7 19 4.9 0.0 3.6 2 1 1 3 3 3 0 Flp/Fap pilin component PriCT_1 PF08708.6 KII72558.1 - 0.48 10.2 3.4 34 4.3 1.4 3.6 2 1 0 2 2 2 0 Primase C terminal 1 (PriCT-1) Ldl_recept_a PF00057.13 KII72560.1 - 2.9e-09 36.6 32.7 3.4e-07 30.0 6.5 3.5 3 1 0 3 3 3 2 Low-density lipoprotein receptor domain class A Kelch_4 PF13418.1 KII72561.1 - 9.8e-19 66.8 12.8 6.6e-05 22.5 0.0 6.5 4 1 2 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 KII72561.1 - 3.7e-17 61.6 21.0 6.3e-06 26.1 0.2 6.4 6 1 1 7 7 7 4 Kelch motif Kelch_1 PF01344.20 KII72561.1 - 9.3e-16 57.1 21.6 0.00026 20.4 0.0 6.1 5 1 1 6 6 6 5 Kelch motif Kelch_3 PF13415.1 KII72561.1 - 2.6e-14 52.9 10.6 0.013 15.6 0.1 6.8 6 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KII72561.1 - 6.7e-10 38.7 17.9 0.0024 17.7 0.7 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KII72561.1 - 2.5e-05 23.8 15.7 0.012 15.3 0.1 5.4 6 0 0 6 6 6 2 Kelch motif RVT_1 PF00078.22 KII72565.1 - 2.8e-28 98.7 0.1 8.2e-28 97.2 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII72565.1 - 7.2e-28 97.1 0.0 1.5e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72565.1 - 0.003 17.0 0.1 0.0069 15.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII72565.1 - 0.014 14.7 0.3 0.061 12.7 0.0 2.2 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger GSH_synth_ATP PF03917.12 KII72565.1 - 0.06 11.9 0.0 0.096 11.2 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain DDE_Tnp_IS1595 PF12762.2 KII72566.1 - 4.8e-24 84.9 0.0 6.6e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF2283 PF10049.4 KII72568.1 - 0.08 12.8 1.8 0.14 12.0 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2283) Lipin_N PF04571.9 KII72568.1 - 0.11 12.1 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 lipin, N-terminal conserved region Pep3_Vps18 PF05131.9 KII72570.1 - 0.085 12.2 0.2 1.4 8.2 0.0 2.0 1 1 1 2 2 2 0 Pep3/Vps18/deep orange family Ldl_recept_a PF00057.13 KII72571.1 - 8.5e-28 95.9 97.4 8.1e-11 41.6 7.6 6.4 6 0 0 6 6 6 6 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII72574.1 - 0.045 13.5 3.4 0.41 10.6 0.3 3.4 3 0 0 3 3 3 0 BNR/Asp-box repeat DUF2163 PF09931.4 KII72576.1 - 0.14 11.8 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2163) FERM_M PF00373.13 KII72579.1 - 0.00067 19.8 0.1 0.0022 18.1 0.0 2.0 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.5 KII72579.1 - 0.056 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 FERM N-terminal domain Pescadillo_N PF06732.6 KII72581.1 - 3.3e-49 167.6 4.6 7.3e-49 166.5 3.2 1.4 1 1 0 1 1 1 1 Pescadillo N-terminus MCM PF00493.18 KII72582.1 - 2.5e-129 430.8 0.0 3.2e-129 430.4 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 KII72582.1 - 1.6e-09 37.2 0.0 8.5e-06 25.0 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KII72582.1 - 1.5e-07 31.2 0.0 5.1e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KII72582.1 - 0.003 17.1 0.0 0.0061 16.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KII72582.1 - 0.019 14.4 0.0 0.23 10.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase_2 PF13335.1 KII72582.1 - 0.12 12.7 1.1 0.37 11.2 0.2 2.2 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI Regulator_TrmB PF11495.3 KII72583.1 - 0.0028 16.6 0.2 0.011 14.7 0.0 1.9 2 0 0 2 2 2 1 Archaeal transcriptional regulator TrmB MH2 PF03166.9 KII72584.1 - 2.5e-31 108.8 0.4 3.5e-31 108.4 0.3 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.11 KII72584.1 - 2.3e-30 104.6 0.0 4e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 MH1 domain NTNH_C PF08470.5 KII72584.1 - 0.039 13.5 0.2 0.07 12.7 0.2 1.3 1 0 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal MULE PF10551.4 KII72585.1 - 2.1e-09 37.4 0.0 5.4e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain I_LWEQ PF01608.12 KII72586.1 - 8.6e-37 126.4 4.8 8.6e-37 126.4 3.3 5.9 7 1 1 8 8 8 1 I/LWEQ domain FERM_M PF00373.13 KII72586.1 - 3.4e-06 27.2 0.4 3.4e-06 27.2 0.2 4.6 5 1 0 5 5 5 1 FERM central domain FERM_N PF09379.5 KII72586.1 - 3.5e-06 26.9 0.1 3.5e-05 23.7 0.1 2.9 1 0 0 1 1 1 1 FERM N-terminal domain VBS PF08913.5 KII72586.1 - 0.0013 18.9 1.5 0.0013 18.9 1.1 5.8 7 0 0 7 7 7 1 Vinculin Binding Site PI3_PI4_kinase PF00454.22 KII72588.1 - 6.6e-39 133.7 0.0 7.5e-28 97.5 0.0 2.1 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase Alba PF01918.16 KII72589.1 - 4.4e-05 23.0 0.3 9.7e-05 21.8 0.1 1.7 2 0 0 2 2 2 1 Alba Pribosyltran PF00156.22 KII72589.1 - 0.042 13.5 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Rpp20 PF12328.3 KII72589.1 - 0.06 12.9 0.1 0.24 11.0 0.1 1.8 1 1 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P TPR_11 PF13414.1 KII72590.1 - 8.1e-12 44.6 2.6 9.9e-08 31.5 0.0 4.0 3 1 2 5 5 5 3 TPR repeat TPR_1 PF00515.23 KII72590.1 - 1.2e-09 37.3 5.1 0.0038 16.7 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII72590.1 - 2.6e-09 36.2 4.8 0.029 14.2 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 KII72590.1 - 5.1e-09 35.6 0.8 0.00067 19.6 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KII72590.1 - 5.4e-06 26.6 0.0 0.061 13.6 0.2 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 KII72590.1 - 1.4e-05 24.9 1.5 0.23 11.4 0.0 3.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KII72590.1 - 1.5e-05 25.4 0.6 0.051 14.2 0.7 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KII72590.1 - 4.2e-05 23.0 6.4 0.12 12.2 0.1 5.0 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 KII72590.1 - 0.00021 20.8 1.0 8.6 6.4 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 KII72590.1 - 0.00027 21.3 0.0 0.24 12.1 0.0 4.0 2 2 2 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 KII72590.1 - 0.0014 18.7 0.9 0.42 10.7 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.4 KII72590.1 - 0.016 14.5 0.2 0.18 11.1 0.1 2.5 2 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_11 PF13414.1 KII72592.1 - 1.5e-16 59.8 7.6 2.8e-09 36.4 0.4 3.5 3 1 1 4 4 4 2 TPR repeat TPR_1 PF00515.23 KII72592.1 - 1.8e-09 36.7 8.6 0.0047 16.4 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KII72592.1 - 4.6e-08 32.3 8.5 0.011 15.6 0.4 5.1 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 KII72592.1 - 8.5e-06 25.5 0.1 0.00027 20.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KII72592.1 - 0.00022 21.1 0.4 0.0011 19.0 0.3 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 KII72592.1 - 0.0014 18.9 5.9 0.009 16.4 0.2 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 KII72592.1 - 0.0018 18.2 0.1 0.0018 18.2 0.1 3.4 3 1 1 4 4 4 1 Tetratricopeptide repeat GDE_C PF06202.9 KII72592.1 - 0.01 14.5 0.7 0.026 13.2 0.2 1.9 2 0 0 2 2 2 0 Amylo-alpha-1,6-glucosidase SHNi-TPR PF10516.4 KII72592.1 - 0.041 13.1 0.1 0.11 11.7 0.1 1.8 1 0 0 1 1 1 0 SHNi-TPR HU-DNA_bdg PF14848.1 KII72592.1 - 0.053 13.2 0.8 0.15 11.7 0.5 1.8 1 0 0 1 1 1 0 DNA-binding domain Fis1_TPR_C PF14853.1 KII72592.1 - 0.058 13.2 10.2 0.75 9.7 1.3 4.3 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.1 KII72592.1 - 0.16 12.3 4.8 0.14 12.5 1.8 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat MIT PF04212.13 KII72592.1 - 0.32 10.8 3.6 16 5.4 0.6 2.9 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.1 KII72592.1 - 0.67 9.8 11.9 5 7.1 0.5 4.6 3 1 1 4 4 4 0 Tetratricopeptide repeat VPS9 PF02204.13 KII72592.1 - 0.68 9.9 7.4 0.64 10.0 0.2 3.6 4 0 0 4 4 3 0 Vacuolar sorting protein 9 (VPS9) domain Apc3 PF12895.2 KII72592.1 - 1.4 9.1 13.9 0.071 13.2 0.9 3.4 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Ras PF00071.17 KII72593.1 - 4.3e-49 166.0 0.8 5.3e-49 165.7 0.5 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII72593.1 - 1e-22 80.8 0.4 5.9e-22 78.3 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KII72593.1 - 6.1e-11 41.8 0.0 7.9e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KII72593.1 - 3.6e-07 29.7 0.2 2.4e-06 27.0 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.12 KII72593.1 - 6.6e-06 25.8 1.8 7.7e-06 25.6 0.1 1.7 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 KII72593.1 - 5.8e-05 23.0 0.2 0.00028 20.8 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_25 PF13481.1 KII72593.1 - 0.0028 17.0 0.0 0.42 9.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain Vps52 PF04129.7 KII72593.1 - 0.011 14.2 0.6 0.018 13.5 0.5 1.3 1 0 0 1 1 1 0 Vps52 / Sac2 family Arch_ATPase PF01637.13 KII72593.1 - 0.019 14.6 2.9 0.032 13.9 1.3 1.8 1 1 1 2 2 2 0 Archaeal ATPase DUF188 PF02639.9 KII72593.1 - 0.033 13.6 0.0 0.064 12.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 KaiC PF06745.8 KII72593.1 - 0.052 12.6 0.6 0.11 11.6 0.2 2.0 1 1 0 1 1 1 0 KaiC ArsD PF06953.6 KII72593.1 - 0.073 13.2 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Arsenical resistance operon trans-acting repressor ArsD AAA_22 PF13401.1 KII72593.1 - 0.08 13.0 0.1 0.44 10.6 0.0 2.2 2 1 0 2 2 2 0 AAA domain CbiA PF01656.18 KII72593.1 - 0.62 9.4 2.7 2.4 7.5 0.2 2.4 1 1 1 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Pkinase PF00069.20 KII72594.1 - 5.9e-70 235.3 0.3 6.9e-70 235.1 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII72594.1 - 1.7e-36 125.6 0.0 1.9e-36 125.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII72594.1 - 1.3e-06 27.6 0.0 2e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KII72594.1 - 3.3e-06 26.3 0.1 5.1e-06 25.7 0.0 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KII72594.1 - 1.5e-05 24.4 0.2 2e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 KII72594.1 - 5.6e-05 22.9 0.1 0.00014 21.6 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KII72594.1 - 0.0024 17.4 2.1 0.0074 15.8 1.5 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.4 KII72594.1 - 0.017 14.4 1.1 0.06 12.6 0.8 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Ribosomal_S18 PF01084.15 KII72595.1 - 0.00023 20.9 0.0 0.00044 20.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 GAGA_bind PF06217.7 KII72596.1 - 0.45 10.4 7.6 0.73 9.7 5.3 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family SspB PF04386.8 KII72596.1 - 0.46 10.0 5.8 0.72 9.4 4.0 1.3 1 0 0 1 1 1 0 Stringent starvation protein B Ribosomal_L28e PF01778.12 KII72597.1 - 4.7e-14 52.8 4.1 5.1e-14 52.6 2.2 1.6 1 1 0 1 1 1 1 Ribosomal L28e protein family zf-TRM13_CCCH PF11722.3 KII72598.1 - 0.058 12.7 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 CCCH zinc finger in TRM13 protein HNOB PF07700.10 KII72600.1 - 0.0081 15.6 0.3 0.011 15.3 0.2 1.3 1 0 0 1 1 1 1 Heme NO binding rve PF00665.21 KII72602.1 - 6.7e-24 84.3 0.0 3.7e-23 81.8 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII72602.1 - 4.1e-16 58.9 0.0 8.5e-16 57.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII72602.1 - 4.8e-08 32.8 0.1 9.7e-08 31.8 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII72602.1 - 8.5e-05 22.3 0.0 0.0002 21.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII72602.1 - 0.00013 22.3 0.0 0.0003 21.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease rve_3 PF13683.1 KII72602.1 - 0.0027 17.1 0.0 0.0087 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII72602.1 - 3.6 7.7 10.5 0.31 11.0 2.4 2.6 2 0 0 2 2 2 0 Zinc knuckle MTBP_C PF14920.1 KII72603.1 - 0.011 15.1 0.9 0.013 15.0 0.6 1.1 1 0 0 1 1 1 0 MDM2-binding DUF4138 PF13595.1 KII72603.1 - 0.017 14.0 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) Ldl_recept_a PF00057.13 KII72604.1 - 0.00019 21.2 20.0 0.0011 18.7 7.4 2.7 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII72605.1 - 1.6e-34 117.5 68.6 3.1e-13 49.3 7.3 4.2 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII72607.1 - 1.5 8.9 8.8 1.3 9.1 0.2 4.5 4 1 1 5 5 5 0 BNR/Asp-box repeat RVT_1 PF00078.22 KII72609.1 - 1.9e-09 37.1 0.1 3.6e-07 29.7 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII72610.1 - 5.7e-05 23.2 0.0 0.00014 21.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Lyase_1 PF00206.15 KII72612.1 - 8e-21 74.5 0.0 1e-20 74.1 0.0 1.1 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 KII72613.1 - 1.9e-08 34.1 0.0 3.2e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus PAF-AH_p_II PF03403.8 KII72613.1 - 0.016 13.5 0.1 0.02 13.1 0.0 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II GED PF02212.13 KII72613.1 - 0.14 12.0 2.3 2.6 7.9 0.1 2.7 2 1 1 3 3 3 0 Dynamin GTPase effector domain ATP-synt_F6 PF05511.6 KII72615.1 - 0.11 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 DUF4093 PF13331.1 KII72615.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) Sugar_tr PF00083.19 KII72616.1 - 6e-18 64.6 7.0 7.1e-18 64.4 4.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Tetraspannin PF00335.15 KII72617.1 - 8.8e-10 38.2 16.7 1.8e-09 37.1 11.6 1.6 1 1 0 1 1 1 1 Tetraspanin family Corona_RPol_N PF06478.8 KII72617.1 - 0.016 13.9 0.8 0.022 13.4 0.5 1.4 1 1 0 1 1 1 0 Coronavirus RPol N-terminus EphA2_TM PF14575.1 KII72617.1 - 2.7 8.4 5.6 9.3 6.7 0.0 3.2 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain UPF0104 PF03706.8 KII72617.1 - 5.2 6.2 16.7 1.3 8.2 8.4 2.1 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0104) DUF3054 PF11255.3 KII72618.1 - 0.038 13.8 0.2 0.064 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3054) TraB PF01963.12 KII72619.1 - 6.6e-05 22.4 1.8 0.019 14.4 0.2 2.6 2 1 0 2 2 2 2 TraB family DUF3786 PF12654.2 KII72620.1 - 0.069 12.4 0.0 0.2 10.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3786) UvsW PF11637.3 KII72620.1 - 0.12 12.0 0.1 0.35 10.5 0.1 1.9 1 1 0 1 1 1 0 ATP-dependant DNA helicase UvsW PLDc_2 PF13091.1 KII72621.1 - 1.1e-20 73.6 0.0 6e-14 51.8 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc_3 PF13918.1 KII72621.1 - 6.5e-08 32.2 0.0 3.1e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 PLD-like domain PLDc PF00614.17 KII72621.1 - 2.6e-05 23.8 0.1 0.0021 17.7 0.1 2.5 2 0 0 2 2 2 1 Phospholipase D Active site motif Tyr-DNA_phospho PF06087.7 KII72621.1 - 0.036 12.6 0.2 0.19 10.2 0.1 1.9 2 0 0 2 2 2 0 Tyrosyl-DNA phosphodiesterase DDE_3 PF13358.1 KII72622.1 - 1.3e-15 57.4 0.0 1.5e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease UDPGT PF00201.13 KII72622.1 - 0.019 13.5 0.0 0.02 13.4 0.0 1.0 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Peptidase_M3_N PF08439.5 KII72622.1 - 0.099 12.7 0.1 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Oligopeptidase F EMI PF07546.8 KII72623.1 - 0.038 14.4 0.5 0.051 14.0 0.3 1.2 1 0 0 1 1 1 0 EMI domain Peptidase_S9 PF00326.16 KII72625.1 - 1.9e-06 27.2 0.0 2.1e-06 27.1 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family PhoPQ_related PF10142.4 KII72625.1 - 0.018 13.5 0.0 0.019 13.4 0.0 1.0 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein RVT_1 PF00078.22 KII72627.1 - 9.3e-16 57.8 0.1 2e-15 56.7 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII72628.1 - 0.0084 16.2 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain PP-binding PF00550.20 KII72630.1 - 0.0013 18.9 0.1 0.0019 18.4 0.1 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF3481 PF11980.3 KII72631.1 - 0.015 15.1 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3481) Shisa PF13908.1 KII72631.1 - 0.018 15.2 0.1 0.018 15.2 0.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator UPF0560 PF10577.4 KII72631.1 - 0.021 13.1 0.2 0.024 12.9 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 IncA PF04156.9 KII72631.1 - 0.037 13.6 0.0 0.045 13.3 0.0 1.1 1 0 0 1 1 1 0 IncA protein DAG1 PF05454.6 KII72631.1 - 0.04 13.1 0.2 0.06 12.5 0.1 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) GP41 PF00517.12 KII72631.1 - 0.1 12.1 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Retroviral envelope protein Adeno_E3_CR2 PF02439.10 KII72631.1 - 0.94 9.0 8.4 1.5 8.4 5.8 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 rve PF00665.21 KII72632.1 - 1.5e-20 73.5 0.1 2.3e-20 72.8 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72632.1 - 0.0011 18.4 0.0 0.0025 17.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII72632.1 - 0.044 13.5 0.1 0.074 12.7 0.1 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Nepo_coat_N PF03689.10 KII72632.1 - 0.05 13.3 0.1 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain OAD_gamma PF04277.8 KII72633.1 - 0.024 14.9 0.0 0.03 14.6 0.0 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Laminin_B PF00052.13 KII72634.1 - 0.13 11.9 0.1 0.15 11.6 0.1 1.1 1 0 0 1 1 1 0 Laminin B (Domain IV) MAPEG PF01124.13 KII72635.1 - 0.17 11.5 1.3 0.23 11.0 0.9 1.1 1 0 0 1 1 1 0 MAPEG family Nipped-B_C PF12830.2 KII72639.1 - 0.045 13.3 0.1 0.75 9.4 0.1 2.2 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus Phage_C PF12025.3 KII72639.1 - 0.11 12.4 0.1 10 6.1 0.0 3.2 2 1 1 3 3 3 0 Phage protein C PsbM PF05151.7 KII72640.1 - 0.061 12.9 1.1 0.061 12.9 0.7 1.8 2 0 0 2 2 2 0 Photosystem II reaction centre M protein (PsbM) Vpu PF00558.14 KII72644.1 - 0.025 14.1 0.0 0.032 13.7 0.0 1.1 1 0 0 1 1 1 0 Vpu protein DUF997 PF06196.7 KII72644.1 - 0.031 13.8 0.3 0.05 13.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF997) DUF843 PF05814.6 KII72644.1 - 0.12 12.1 0.1 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) MULE PF10551.4 KII72647.1 - 0.00068 19.7 0.1 0.0013 18.8 0.1 1.6 1 0 0 1 1 1 1 MULE transposase domain Mpp10 PF04006.7 KII72648.1 - 2.3e-10 39.5 7.1 2.5e-10 39.3 4.9 1.0 1 0 0 1 1 1 1 Mpp10 protein zf-DHHC PF01529.15 KII72649.1 - 0.21 10.9 6.4 0.29 10.5 4.4 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase SUR7 PF06687.7 KII72649.1 - 1.5 8.3 10.3 1.2 8.6 5.5 1.9 1 1 1 2 2 2 0 SUR7/PalI family RNase_T PF00929.19 KII72651.1 - 3.5e-23 82.6 0.3 9.7e-23 81.2 0.0 1.9 2 1 0 2 2 2 1 Exonuclease zf-dskA_traR PF01258.12 KII72651.1 - 6.5e-10 38.5 3.0 1.3e-09 37.5 2.1 1.5 1 0 0 1 1 1 1 Prokaryotic dksA/traR C4-type zinc finger DNA_pol_A_exo1 PF01612.15 KII72651.1 - 0.00011 21.6 0.5 0.00059 19.3 0.3 2.2 1 1 0 1 1 1 1 3'-5' exonuclease RNase_H_2 PF13482.1 KII72651.1 - 0.047 13.4 0.0 0.11 12.2 0.0 1.6 1 1 0 1 1 1 0 RNase_H superfamily Phage_CP76 PF06892.6 KII72653.1 - 2.2e-53 179.9 0.4 2.4e-53 179.7 0.3 1.0 1 0 0 1 1 1 1 Phage regulatory protein CII (CP76) PsbW PF07123.7 KII72653.1 - 0.094 12.7 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) DDE_Tnp_IS240 PF13610.1 KII72653.1 - 0.12 12.3 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 DDE domain Phage_CI_repr PF07022.8 KII72654.1 - 3.9e-23 81.3 0.0 7.1e-23 80.4 0.0 1.4 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain Peptidase_C5 PF00770.13 KII72656.1 - 0.091 12.3 0.2 0.13 11.8 0.1 1.4 1 1 0 1 1 1 0 Adenovirus endoprotease BNR PF02012.15 KII72656.1 - 0.1 12.5 0.1 2 8.5 0.0 2.6 2 0 0 2 2 2 0 BNR/Asp-box repeat zf-CCHC_4 PF14392.1 KII72658.1 - 0.00016 21.2 11.9 0.012 15.2 1.8 2.8 2 0 0 2 2 2 2 Zinc knuckle Arrestin_C PF02752.17 KII72658.1 - 0.00078 19.5 0.3 0.0018 18.3 0.2 1.8 1 1 1 2 2 2 1 Arrestin (or S-antigen), C-terminal domain zf-CCHC PF00098.18 KII72658.1 - 0.11 12.4 12.5 0.84 9.6 2.1 2.4 2 0 0 2 2 2 0 Zinc knuckle Cript PF10235.4 KII72658.1 - 1.9 8.8 7.5 2.4 8.5 0.2 2.5 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT RVT_1 PF00078.22 KII72661.1 - 3e-15 56.1 0.0 5e-15 55.4 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII72662.1 - 1.3e-10 41.3 0.0 1.6e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72662.1 - 4.3e-05 22.9 0.0 5.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.1 KII72663.1 - 0.0027 18.1 0.0 0.0043 17.5 0.0 1.4 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII72663.1 - 0.0069 16.1 0.0 0.021 14.6 0.0 1.8 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVT_1 PF00078.22 KII72664.1 - 1.4e-06 27.8 0.0 1.8e-06 27.4 0.0 1.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Microcin PF03526.8 KII72665.1 - 0.018 14.6 0.3 0.03 13.9 0.2 1.3 1 0 0 1 1 1 0 Colicin E1 (microcin) immunity protein DDE_Tnp_4 PF13359.1 KII72666.1 - 0.026 14.1 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease rve PF00665.21 KII72666.1 - 0.032 14.3 0.1 0.52 10.4 0.0 2.2 1 1 1 2 2 2 0 Integrase core domain rve_3 PF13683.1 KII72666.1 - 0.052 13.0 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Suppressor_P21 PF11479.3 KII72666.1 - 0.062 13.0 0.2 0.33 10.6 0.0 1.9 2 0 0 2 2 2 0 RNA silencing suppressor P21 ATP-synt_B PF00430.13 KII72666.1 - 0.11 12.3 1.5 0.12 12.1 0.1 1.7 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) AT_hook PF02178.14 KII72667.1 - 2.6 8.0 9.5 0.16 11.7 1.0 2.6 2 0 0 2 2 2 0 AT hook motif BNR PF02012.15 KII72668.1 - 0.00021 20.6 0.6 0.15 12.0 0.5 2.7 2 0 0 2 2 2 2 BNR/Asp-box repeat Pneumo_NS1 PF03438.8 KII72668.1 - 0.073 12.8 0.1 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 Pneumovirus NS1 protein rve_3 PF13683.1 KII72669.1 - 0.019 14.4 0.0 0.074 12.5 0.0 2.0 1 0 0 1 1 1 0 Integrase core domain DUF3967 PF13152.1 KII72669.1 - 0.081 12.5 0.2 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3967) DUF448 PF04296.8 KII72670.1 - 0.024 14.2 0.1 0.055 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF448) DUF2042 PF09743.4 KII72671.1 - 2e-14 53.5 0.1 2.5e-14 53.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2042) BRCT PF00533.21 KII72671.1 - 0.046 13.8 0.2 0.83 9.8 0.0 2.2 1 1 1 2 2 2 0 BRCA1 C Terminus (BRCT) domain Phtf-FEM1B_bdg PF12129.3 KII72673.1 - 0.042 13.1 0.1 0.096 12.0 0.0 1.5 1 1 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor Dimer_Tnp_hAT PF05699.9 KII72674.1 - 0.00066 19.2 0.2 0.0011 18.4 0.2 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region SNAP PF14938.1 KII72675.1 - 1.2e-10 41.0 3.4 1.8e-10 40.4 2.4 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.1 KII72675.1 - 6e-05 22.5 1.4 1.7 8.5 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KII72675.1 - 0.00016 21.1 15.0 0.016 14.8 0.1 4.9 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 KII72675.1 - 0.0047 16.8 1.6 1.9 8.4 0.0 3.2 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII72675.1 - 0.0067 16.0 6.2 4.5 6.9 0.1 4.4 2 1 2 4 4 4 2 TPR repeat RPN7 PF10602.4 KII72675.1 - 0.0068 15.8 5.3 3.5 6.9 1.9 3.6 1 1 1 2 2 2 2 26S proteasome subunit RPN7 TPR_2 PF07719.12 KII72675.1 - 0.073 13.0 14.2 2.6 8.1 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR PF01535.15 KII72675.1 - 0.081 12.9 3.9 0.63 10.1 0.1 3.1 3 0 0 3 3 3 0 PPR repeat RNA_pol_N PF01194.12 KII72675.1 - 0.097 12.7 0.1 0.43 10.6 0.1 2.1 1 0 0 1 1 1 0 RNA polymerases N / 8 kDa subunit TPR_8 PF13181.1 KII72675.1 - 0.14 12.0 11.8 1.1 9.1 0.0 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KII72675.1 - 0.98 10.0 3.2 62 4.3 0.3 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat NSF PF02071.15 KII72675.1 - 2.3 9.1 11.0 9.3 7.3 0.2 4.3 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat SNAP PF14938.1 KII72676.1 - 7.1e-13 48.3 0.1 8.2e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII72676.1 - 3e-05 23.8 1.5 0.0027 17.6 0.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KII72676.1 - 0.036 13.8 1.9 16 5.6 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII72676.1 - 0.048 13.3 0.1 0.19 11.3 0.1 2.2 1 1 0 1 1 1 0 TPR repeat SelA PF03841.8 KII72676.1 - 0.079 11.6 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase TPR_8 PF13181.1 KII72676.1 - 0.33 10.8 4.8 18 5.4 0.0 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII72676.1 - 0.39 10.7 6.1 35 4.6 0.0 4.8 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII72676.1 - 0.55 9.9 7.6 5.8 6.7 0.0 5.1 6 1 1 7 7 7 0 Tetratricopeptide repeat DUF4052 PF13261.1 KII72677.1 - 0.059 12.8 0.0 0.073 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4052) EGF_2 PF07974.8 KII72678.1 - 3.6 7.8 10.4 0.71 10.0 0.2 3.1 2 1 1 3 3 3 0 EGF-like domain Rep_fac_C PF08542.6 KII72680.1 - 2.1e-12 46.8 0.0 3e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Replication factor C C-terminal domain DUF4542 PF15075.1 KII72681.1 - 0.02 14.8 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4542) Galactosyl_T PF01762.16 KII72682.1 - 1.7e-29 102.8 0.6 2.4e-29 102.3 0.4 1.2 1 0 0 1 1 1 1 Galactosyltransferase rve PF00665.21 KII72683.1 - 2.8e-24 85.5 0.0 1.2e-23 83.5 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII72683.1 - 1.8e-23 83.0 0.5 7.4e-23 81.0 0.1 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII72683.1 - 9.5e-07 28.6 0.0 2.4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.5 KII72683.1 - 0.00029 20.1 0.0 0.00064 19.0 0.0 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve_3 PF13683.1 KII72683.1 - 0.00077 18.9 0.1 0.0068 15.9 0.1 2.4 2 0 0 2 2 2 1 Integrase core domain DUF904 PF06005.7 KII72683.1 - 0.0039 17.4 3.2 0.47 10.7 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF904) zf-CCHC PF00098.18 KII72683.1 - 0.0061 16.4 5.3 0.37 10.8 0.5 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII72683.1 - 0.2 12.1 0.0 0.46 11.0 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Galactosyl_T PF01762.16 KII72684.1 - 3.7e-28 98.4 0.1 5.5e-28 97.9 0.1 1.3 1 0 0 1 1 1 1 Galactosyltransferase BEN PF10523.4 KII72684.1 - 0.035 14.1 0.1 0.15 12.1 0.1 2.1 1 1 1 2 2 2 0 BEN domain Galactosyl_T PF01762.16 KII72686.1 - 5.1e-27 94.7 0.6 6.6e-27 94.3 0.4 1.2 1 0 0 1 1 1 1 Galactosyltransferase FLYWCH PF04500.11 KII72687.1 - 3.4e-09 36.4 1.9 5.2e-09 35.8 1.3 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain Mob_synth_C PF06463.8 KII72688.1 - 5.9e-25 87.4 0.0 6.5e-25 87.2 0.0 1.0 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Tetraspannin PF00335.15 KII72689.1 - 4e-14 52.4 9.2 4.8e-14 52.1 6.4 1.0 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.10 KII72689.1 - 0.0033 17.3 3.3 0.0087 16.0 2.3 1.8 1 1 0 1 1 1 1 CD20-like family PHO4 PF01384.15 KII72689.1 - 0.02 13.5 7.5 0.0083 14.8 3.6 1.4 1 1 0 1 1 1 0 Phosphate transporter family Glycophorin_A PF01102.13 KII72689.1 - 0.41 10.4 0.0 0.41 10.4 0.0 2.4 2 1 1 3 3 3 0 Glycophorin A Toxin_21 PF08091.6 KII72690.1 - 0.0081 15.8 0.5 0.014 15.0 0.3 1.3 1 0 0 1 1 1 1 Spider insecticidal peptide SpvD PF05563.7 KII72691.1 - 0.099 12.1 1.0 0.13 11.7 0.7 1.1 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD DDE_3 PF13358.1 KII72694.1 - 4.9e-26 91.2 0.0 8.5e-26 90.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII72694.1 - 0.00015 21.7 0.3 0.00042 20.3 0.1 1.8 2 0 0 2 2 2 1 Transposase rve PF00665.21 KII72694.1 - 0.0003 20.8 0.0 0.001 19.1 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain HTH_33 PF13592.1 KII72694.1 - 0.054 13.0 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_IS630 PF01710.11 KII72694.1 - 0.076 12.6 0.6 0.84 9.3 0.4 2.1 1 1 1 2 2 2 0 Transposase 2OG-FeII_Oxy PF03171.15 KII72695.1 - 3.5e-06 27.2 0.0 5.7e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KII72695.1 - 5.6e-06 26.8 0.0 9.4e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily P4Ha_N PF08336.6 KII72696.1 - 1.1e-15 57.5 0.0 2.5e-15 56.4 0.0 1.6 1 1 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Strep_67kDa_ant PF06100.6 KII72696.1 - 0.066 11.5 0.1 0.073 11.4 0.0 1.2 1 0 0 1 1 1 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family P4Ha_N PF08336.6 KII72697.1 - 1e-10 41.5 0.3 3.2e-10 39.9 0.0 2.0 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.1 KII72697.1 - 5.5e-06 26.8 0.1 1.3e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.12 KII72697.1 - 8.1e-05 22.2 0.0 0.024 14.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII72697.1 - 0.0018 18.0 0.0 0.0052 16.6 0.0 1.7 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat MSP7_C PF12948.2 KII72697.1 - 0.025 14.8 3.3 1.3 9.2 0.2 2.6 2 0 0 2 2 2 0 MSP7-like protein C-terminal domain HTH_9 PF08221.6 KII72698.1 - 6.6e-08 32.3 0.7 0.00082 19.1 0.1 2.3 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF2132 PF09905.4 KII72698.1 - 0.027 14.4 0.1 0.86 9.6 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2132) Tn7_Tnp_TnsA_C PF08721.6 KII72698.1 - 0.042 13.8 0.2 3.4 7.7 0.0 2.4 2 0 0 2 2 2 0 TnsA endonuclease C terminal MAGE PF01454.14 KII72698.1 - 0.066 12.5 0.1 0.097 12.0 0.0 1.3 1 1 0 1 1 1 0 MAGE family RPA_C PF08784.6 KII72698.1 - 0.1 12.9 0.1 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal DnaJ PF00226.26 KII72700.1 - 8.2e-24 83.1 0.0 1.1e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain DUF4108 PF13390.1 KII72701.1 - 0.0061 16.2 1.4 0.19 11.4 0.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF4108) DUF908 PF06012.7 KII72701.1 - 0.14 11.3 0.1 0.18 11.1 0.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Prok-RING_4 PF14447.1 KII72702.1 - 0.02 14.4 0.2 0.052 13.0 0.0 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 NinF PF05810.7 KII72702.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 NinF protein Cyto_heme_lyase PF01265.12 KII72703.1 - 9.5e-73 244.9 0.5 1.2e-72 244.6 0.4 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase NAC PF01849.13 KII72704.1 - 1e-09 37.7 0.0 2e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 NAC domain DUF3135 PF11333.3 KII72704.1 - 0.096 12.8 0.2 0.27 11.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Pro_isomerase PF00160.16 KII72705.1 - 1.9e-49 167.8 0.2 2.2e-49 167.6 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thymosin PF01290.15 KII72707.1 - 4.6e-17 61.3 1.1 7.6e-17 60.6 0.8 1.3 1 0 0 1 1 1 1 Thymosin beta-4 family WH2 PF02205.15 KII72707.1 - 0.18 11.4 1.2 0.59 9.8 0.8 1.9 1 1 0 1 1 1 0 WH2 motif UAA PF08449.6 KII72708.1 - 1.9e-45 155.0 26.4 2.3e-45 154.8 18.3 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KII72708.1 - 1.8e-11 43.8 28.1 4.5e-10 39.3 4.2 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KII72708.1 - 1.3e-05 25.2 22.1 0.0063 16.5 5.6 2.6 2 1 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 KII72708.1 - 0.009 16.1 20.1 0.21 11.8 1.9 2.9 2 1 0 2 2 2 2 Multidrug resistance efflux transporter Na_K-ATPase PF00287.13 KII72708.1 - 0.17 10.6 3.7 0.052 12.3 0.4 1.6 2 0 0 2 2 2 0 Sodium / potassium ATPase beta chain DUF2975 PF11188.3 KII72708.1 - 3.6 7.3 25.9 0.65 9.7 0.4 4.3 1 1 3 5 5 5 0 Protein of unknown function (DUF2975) RVP PF00077.15 KII72711.1 - 5.7e-06 26.1 0.0 1.4e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII72711.1 - 3e-05 23.5 0.0 0.00014 21.4 0.0 2.0 2 1 0 2 2 2 1 Aspartyl protease UBN2 PF14223.1 KII72711.1 - 0.00039 20.1 0.1 0.0013 18.4 0.0 1.9 1 1 1 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.18 KII72711.1 - 0.0095 15.8 2.2 0.0095 15.8 1.5 2.7 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.1 KII72711.1 - 0.027 14.1 14.3 0.25 11.0 0.8 2.6 1 1 1 2 2 2 0 Zinc knuckle RVT_1 PF00078.22 KII72711.1 - 0.028 13.7 0.0 0.053 12.8 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.1 KII72711.1 - 0.09 13.2 0.0 0.81 10.2 0.0 2.5 1 1 0 1 1 1 0 Aspartyl protease RNA_pol PF00940.14 KII72711.1 - 0.1 11.0 0.0 0.17 10.3 0.0 1.3 1 0 0 1 1 1 0 DNA-dependent RNA polymerase gag-asp_proteas PF13975.1 KII72711.1 - 0.16 11.8 0.0 0.41 10.4 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF1192 PF06698.6 KII72711.1 - 0.27 11.0 1.8 2.6 7.9 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) zf-CCHC_4 PF14392.1 KII72711.1 - 3 7.5 11.9 3.1 7.5 0.3 3.0 2 0 0 2 2 2 0 Zinc knuckle Phenol_hyd_sub PF06099.6 KII72712.1 - 0.17 11.7 0.8 0.52 10.1 0.1 2.0 2 0 0 2 2 2 0 Phenol hydroxylase subunit rve PF00665.21 KII72714.1 - 2.6e-20 72.6 0.0 5.3e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72714.1 - 0.00046 19.6 0.1 0.001 18.5 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Retrotrans_gag PF03732.12 KII72715.1 - 0.0011 19.0 0.0 0.0022 18.0 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon gag protein Phage_connect_1 PF05135.8 KII72716.1 - 0.0052 16.9 1.1 0.0077 16.3 0.7 1.5 1 1 0 1 1 1 1 Phage gp6-like head-tail connector protein T_Ag_DNA_bind PF02217.11 KII72717.1 - 0.17 12.2 3.0 0.093 13.1 0.8 1.6 2 0 0 2 2 2 0 Origin of replication binding protein Clathrin-link PF09268.5 KII72718.1 - 0.074 12.1 0.2 0.15 11.1 0.1 1.4 1 0 0 1 1 1 0 Clathrin, heavy-chain linker Cu_amine_oxidN3 PF02728.11 KII72719.1 - 0.024 14.6 0.2 0.7 9.9 0.0 3.0 2 1 1 3 3 3 0 Copper amine oxidase, N3 domain SdpI PF13630.1 KII72720.1 - 0.0008 19.0 2.8 0.0017 18.0 2.0 1.5 1 0 0 1 1 1 1 SdpI/YhfL protein family Glucos_trans_II PF14264.1 KII72720.1 - 0.019 14.0 2.8 0.03 13.3 1.9 1.3 1 0 0 1 1 1 0 Glucosyl transferase GtrII DUF3816 PF12822.2 KII72720.1 - 0.047 13.5 3.3 0.094 12.5 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3816) DUF3753 PF12575.3 KII72720.1 - 0.11 12.3 3.8 0.38 10.5 2.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Rifin_STEVOR PF02009.11 KII72720.1 - 0.25 10.9 5.0 0.067 12.8 1.2 1.6 2 0 0 2 2 2 0 Rifin/stevor family rve PF00665.21 KII72728.1 - 2.6e-28 98.5 0.0 4.5e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72728.1 - 0.0012 18.3 0.1 0.0028 17.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII72728.1 - 0.0034 16.7 0.3 0.025 13.9 0.0 2.5 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger Ldl_recept_a PF00057.13 KII72730.1 - 2.2e-09 37.0 6.0 2.2e-09 37.0 4.1 2.6 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A RVT_1 PF00078.22 KII72731.1 - 2.6e-15 56.3 0.1 1.1e-14 54.3 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII72731.1 - 1.6e-07 31.1 0.2 3.7e-07 29.9 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII72731.1 - 2.2e-06 28.0 0.0 5.4e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII72731.1 - 6.3e-06 25.9 0.0 1.6e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII72731.1 - 0.0026 17.7 0.0 0.0056 16.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII72731.1 - 0.017 14.7 0.0 0.045 13.3 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.1 KII72731.1 - 0.051 13.0 3.9 0.13 11.7 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger XRCC4 PF06632.7 KII72734.1 - 0.2 10.4 3.6 0.27 10.0 2.5 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Cofilin_ADF PF00241.15 KII72735.1 - 3.8e-19 68.8 0.4 4.5e-19 68.5 0.2 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein YolD PF08863.5 KII72735.1 - 0.016 15.0 0.3 0.32 10.8 0.2 2.1 2 0 0 2 2 2 0 YolD-like protein DUF1789 PF08748.6 KII72735.1 - 0.059 13.4 0.1 0.11 12.6 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1789) rve PF00665.21 KII72736.1 - 1.1e-26 93.3 0.0 2.1e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII72736.1 - 7.8e-23 80.9 0.3 2.1e-22 79.5 0.1 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII72736.1 - 0.00097 18.6 0.0 0.003 17.0 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain DUF2577 PF10844.3 KII72736.1 - 0.089 12.8 0.1 0.25 11.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2577) Serpin PF00079.15 KII72737.1 - 3.2e-24 85.7 0.1 3.5e-24 85.6 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cornichon PF03311.9 KII72737.1 - 0.005 16.9 0.1 0.031 14.4 0.0 2.2 2 0 0 2 2 2 1 Cornichon protein Serpin PF00079.15 KII72739.1 - 2e-23 83.1 1.2 2.5e-23 82.8 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII72740.1 - 1.7e-16 60.3 0.2 1.8e-16 60.2 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CagZ PF09053.5 KII72740.1 - 0.023 14.0 0.1 0.029 13.7 0.0 1.1 1 0 0 1 1 1 0 CagZ Topoisom_I_N PF02919.10 KII72740.1 - 0.19 10.9 0.5 0.23 10.6 0.4 1.1 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment AFT PF08731.6 KII72741.1 - 0.094 12.9 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Transcription factor AFT HECT PF00632.20 KII72743.1 - 9.2e-14 51.3 0.4 1.3e-13 50.8 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Flp_N PF03930.9 KII72744.1 - 0.16 11.7 3.7 0.19 11.4 0.4 2.6 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus Serpin PF00079.15 KII72746.1 - 1.3e-15 57.4 2.8 1.4e-15 57.3 2.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.1 KII72747.1 - 2.3e-09 36.8 1.2 2.6e-09 36.6 0.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.23 KII72747.1 - 0.13 11.9 2.6 26 4.6 0.0 3.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII72747.1 - 2.4 8.2 5.4 14 5.9 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat zf-LITAF-like PF10601.4 KII72748.1 - 0.034 14.0 0.7 0.08 12.8 0.5 1.6 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain Imm17 PF15591.1 KII72749.1 - 2.9e-09 36.5 29.7 9.1 6.1 0.1 9.1 1 1 8 9 9 9 9 Immunity protein 17 Tautomerase PF01361.16 KII72749.1 - 0.003 17.1 32.6 2.6 7.7 0.1 9.2 9 0 0 9 9 9 9 Tautomerase enzyme MNNL PF07657.8 KII72750.1 - 0.23 11.3 2.7 0.43 10.5 1.8 1.4 1 0 0 1 1 1 0 N terminus of Notch ligand WD40 PF00400.27 KII72751.1 - 2.5e-14 52.5 0.7 7.3e-06 25.6 0.0 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat PP2C PF00481.16 KII72752.1 - 0.057 12.8 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C PP2C PF00481.16 KII72753.1 - 3.8e-22 78.9 0.0 4.4e-22 78.7 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C DNA_pol_B PF00136.16 KII72754.1 - 4.5e-40 137.8 0.0 5e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase family B XhlA PF10779.4 KII72754.1 - 0.001 18.8 0.1 0.0019 18.0 0.0 1.3 1 0 0 1 1 1 1 Haemolysin XhlA PQ-loop PF04193.9 KII72755.1 - 7.9e-21 73.3 2.0 1.3e-15 56.6 0.3 2.7 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.13 KII72755.1 - 0.0017 18.8 6.9 0.0017 18.8 4.8 1.8 1 1 1 2 2 2 1 ER lumen protein retaining receptor SdpI PF13630.1 KII72755.1 - 0.12 12.0 3.3 7.1 6.4 0.0 2.5 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF1772 PF08592.6 KII72755.1 - 0.26 10.9 2.0 0.4 10.3 1.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) MtN3_slv PF03083.11 KII72755.1 - 0.38 10.6 10.9 2 8.3 2.1 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Laminin_I PF06008.9 KII72756.1 - 0.0081 15.5 0.3 0.011 15.0 0.2 1.2 1 0 0 1 1 1 1 Laminin Domain I Cyclin_C PF02984.14 KII72756.1 - 0.014 15.3 0.4 0.038 13.9 0.2 1.8 2 1 0 2 2 2 0 Cyclin, C-terminal domain RIH_assoc PF08454.6 KII72756.1 - 0.21 11.2 3.4 0.51 9.9 2.3 1.6 1 1 0 1 1 1 0 RyR and IP3R Homology associated Endonuc_Holl PF10107.4 KII72756.1 - 0.34 10.5 1.7 1.8 8.2 1.2 2.0 1 1 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase OB_NTP_bind PF07717.11 KII72757.1 - 1e-23 83.3 0.3 3.7e-23 81.5 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 KII72757.1 - 1.7e-16 60.0 0.0 4.1e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) DinB PF05163.7 KII72757.1 - 0.015 15.0 0.5 0.028 14.1 0.3 1.4 1 0 0 1 1 1 0 DinB family FlaF PF07309.6 KII72757.1 - 0.058 13.2 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 Flagellar protein FlaF Helicase_C PF00271.26 KII72758.1 - 5.5e-12 45.3 0.1 2.4e-11 43.3 0.0 2.2 3 0 0 3 3 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KII72758.1 - 2.8e-08 33.4 0.0 7.5e-08 32.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KII72758.1 - 9.7e-06 25.7 0.0 2.4e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 KII72758.1 - 0.00016 21.5 1.7 0.19 11.5 0.0 3.3 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 KII72758.1 - 0.00051 19.8 0.0 0.00095 18.9 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_23 PF13476.1 KII72758.1 - 0.011 16.1 0.5 0.011 16.1 0.4 3.0 1 1 2 3 3 3 0 AAA domain T2SE PF00437.15 KII72758.1 - 0.011 14.6 0.0 0.021 13.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.1 KII72758.1 - 0.019 14.8 0.8 0.19 11.6 0.6 2.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KII72758.1 - 0.036 13.5 0.0 0.084 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.17 KII72758.1 - 0.04 13.3 0.2 0.11 11.9 0.1 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Peptidase_S41 PF03572.13 KII72758.1 - 0.061 12.7 0.1 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Peptidase family S41 AAA_25 PF13481.1 KII72758.1 - 0.09 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 KII72758.1 - 0.096 11.7 2.9 0.28 10.2 0.3 2.4 1 1 1 2 2 2 0 KaiC DUF1382 PF07131.6 KII72758.1 - 0.13 12.3 0.0 0.39 10.8 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1382) ABC_tran PF00005.22 KII72758.1 - 0.35 11.1 2.5 0.6 10.4 0.0 2.6 3 0 0 3 3 3 0 ABC transporter UBA_3 PF09288.5 KII72759.1 - 0.003 17.1 0.0 0.006 16.1 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain IF4E PF01652.13 KII72760.1 - 7.8e-37 126.3 0.4 9.4e-37 126.0 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DHquinase_I PF01487.10 KII72760.1 - 0.036 13.7 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 Type I 3-dehydroquinase DUF1307 PF06998.6 KII72769.1 - 0.008 16.2 0.6 0.66 10.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1307) DUF2344 PF10105.4 KII72769.1 - 0.036 13.5 0.1 0.044 13.2 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) DUF2839 PF10999.3 KII72770.1 - 0.032 14.2 0.0 0.049 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2839) Shisa PF13908.1 KII72770.1 - 0.06 13.5 0.1 0.082 13.0 0.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF912 PF06024.7 KII72770.1 - 0.068 13.2 0.6 0.11 12.5 0.4 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Podoplanin PF05808.6 KII72770.1 - 0.13 11.8 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Podoplanin DUF4094 PF13334.1 KII72770.1 - 1.7 9.1 4.0 1.7 9.0 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) SNAP PF14938.1 KII72773.1 - 1.6e-12 47.2 2.2 1.6e-12 47.2 1.5 1.9 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP UPF0203 PF05254.7 KII72773.1 - 0.081 12.7 0.2 0.081 12.7 0.1 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0203) rve PF00665.21 KII72775.1 - 0.0021 18.1 0.0 0.0048 17.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Rep_fac-A_C PF08646.5 KII72776.1 - 0.04 13.6 2.0 0.04 13.6 1.4 1.6 2 0 0 2 2 2 0 Replication factor-A C terminal domain DMAP1 PF05499.7 KII72777.1 - 0.095 12.2 0.0 0.15 11.5 0.0 1.3 1 1 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) AdoHcyase PF05221.12 KII72782.1 - 6.2e-99 330.2 0.1 7e-99 330.1 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KII72782.1 - 1.8e-73 245.7 1.2 2.5e-73 245.2 0.8 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 KII72782.1 - 1.1e-11 44.1 0.2 2.1e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 KII72782.1 - 1.7e-05 24.2 0.4 2.8e-05 23.5 0.3 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 KII72782.1 - 3.2e-05 23.9 0.3 8.9e-05 22.4 0.2 1.8 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.1 KII72782.1 - 0.00015 21.9 0.4 0.00054 20.1 0.2 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.14 KII72782.1 - 0.00083 18.4 1.9 0.0048 15.9 1.3 2.0 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ELFV_dehydrog PF00208.16 KII72782.1 - 0.044 13.3 0.4 0.074 12.6 0.3 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase PMP1_2 PF08114.6 KII72785.1 - 0.071 12.6 0.6 0.18 11.3 0.1 1.9 2 0 0 2 2 2 0 ATPase proteolipid family Exonuc_VIII PF06630.6 KII72786.1 - 0.15 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII DUF3869 PF12985.2 KII72788.1 - 1.9 8.9 5.4 12 6.3 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3869) DUF443 PF04276.7 KII72790.1 - 0.00083 18.8 0.4 0.0018 17.7 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF443) DUF1389 PF07146.6 KII72791.1 - 0.067 12.2 0.4 0.11 11.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1389) Baculo_PEP_C PF04513.7 KII72798.1 - 0.032 14.0 3.5 0.78 9.5 0.3 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FBP PF07299.6 KII72798.1 - 0.043 13.1 2.7 0.072 12.4 0.1 2.3 2 1 0 2 2 2 0 Fibronectin-binding protein (FBP) COG5 PF10392.4 KII72798.1 - 0.066 13.1 2.6 0.23 11.4 0.0 2.7 3 1 0 3 3 3 0 Golgi transport complex subunit 5 Wx5_PLAF3D7 PF09688.5 KII72798.1 - 0.11 12.4 3.6 3.8 7.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) BLOC1_2 PF10046.4 KII72798.1 - 0.14 12.3 4.1 5.8 7.1 0.4 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1722 PF08349.6 KII72798.1 - 0.21 11.4 2.6 1.8 8.4 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) SPX PF03105.14 KII72798.1 - 0.92 9.2 5.0 1.6 8.4 3.5 1.6 1 1 0 1 1 1 0 SPX domain DUF869 PF05911.6 KII72798.1 - 0.99 7.5 5.0 0.21 9.8 0.4 1.8 2 0 0 2 2 2 0 Plant protein of unknown function (DUF869) Fib_alpha PF08702.5 KII72798.1 - 2.7 8.1 7.4 10 6.2 0.9 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SNF2_N PF00176.18 KII72799.1 - 4.2e-67 226.0 0.7 6.6e-67 225.4 0.5 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 KII72799.1 - 2.7e-26 91.0 2.4 6.8e-14 51.2 0.0 3.6 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 KII72799.1 - 1.3e-15 57.0 0.0 2.9e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.1 KII72799.1 - 1.5e-05 25.0 0.6 0.0001 22.4 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) FliH PF02108.11 KII72800.1 - 0.055 13.3 0.0 0.067 13.0 0.0 1.4 1 1 0 1 1 1 0 Flagellar assembly protein FliH DUF161 PF02588.10 KII72802.1 - 0.35 11.1 4.0 1.5 9.1 0.2 2.3 1 1 1 2 2 2 0 Uncharacterized BCR, YitT family COG1284 DDE_Tnp_IS1595 PF12762.2 KII72804.1 - 5.1e-24 84.8 2.3 8.1e-24 84.1 0.3 2.1 2 1 0 2 2 2 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII72804.1 - 0.028 14.1 0.1 0.083 12.6 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease DDE_Tnp_IS66 PF03050.9 KII72804.1 - 0.048 12.8 0.0 0.06 12.5 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family PX PF00787.19 KII72804.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 PX domain WD40 PF00400.27 KII72806.1 - 1.3e-40 135.8 35.9 2.1e-09 36.9 0.0 9.2 10 0 0 10 10 10 6 WD domain, G-beta repeat Utp12 PF04003.7 KII72806.1 - 5e-18 65.0 0.1 9.8e-18 64.0 0.1 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family PD40 PF07676.7 KII72806.1 - 0.022 14.3 0.0 17 5.2 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF4216 PF13952.1 KII72807.1 - 0.086 12.3 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4216) WD40 PF00400.27 KII72808.1 - 9.4e-25 85.5 11.9 3.5e-08 33.0 0.1 5.2 4 1 1 5 5 5 5 WD domain, G-beta repeat HTH_1 PF00126.22 KII72809.1 - 4.8e-18 64.6 0.2 8.1e-18 63.9 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.15 KII72809.1 - 2.8e-06 26.5 0.1 6.7e-06 25.3 0.0 1.7 2 0 0 2 2 2 1 LysR substrate binding domain HTH_IclR PF09339.5 KII72809.1 - 0.043 13.4 0.1 0.11 12.0 0.0 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain MarR_2 PF12802.2 KII72809.1 - 0.059 13.0 0.1 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 MarR family Aldo_ket_red PF00248.16 KII72810.1 - 4.4e-67 225.8 0.0 5.4e-67 225.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Flavodoxin_2 PF02525.12 KII72811.1 - 2.8e-24 85.7 0.0 3.1e-24 85.6 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold Flavin_Reduct PF01613.13 KII72812.1 - 2.3e-05 24.2 0.0 3.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain HxlR PF01638.12 KII72813.1 - 3.7e-27 93.7 0.1 4.6e-27 93.4 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix KfrA_N PF11740.3 KII72813.1 - 0.00031 21.1 0.1 0.00044 20.6 0.0 1.1 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term HTH_20 PF12840.2 KII72813.1 - 0.016 15.0 0.1 0.024 14.4 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DUF505 PF04458.7 KII72813.1 - 0.021 12.9 0.0 0.026 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) PadR PF03551.9 KII72813.1 - 0.043 13.5 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family MarR_2 PF12802.2 KII72813.1 - 0.075 12.7 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 MarR family HTH_45 PF14947.1 KII72813.1 - 0.12 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix SnoaL PF07366.7 KII72814.1 - 1.1e-10 41.1 0.1 1.5e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 KII72814.1 - 9.8e-06 25.9 0.0 1.3e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain YceI PF04264.8 KII72815.1 - 1.1e-29 103.5 0.6 1.2e-29 103.3 0.4 1.0 1 0 0 1 1 1 1 YceI-like domain Nitroreductase PF00881.19 KII72816.1 - 4.8e-17 62.2 0.0 5.6e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family CPSF_A PF03178.10 KII72816.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 CPSF A subunit region Kelch_4 PF13418.1 KII72817.1 - 9.7e-08 31.6 3.1 0.12 12.1 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.1 KII72817.1 - 1.5e-05 24.9 4.0 0.12 12.5 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 KII72817.1 - 0.00067 19.7 0.6 5.1 7.4 0.0 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.20 KII72817.1 - 0.0014 18.1 6.8 1.4 8.4 0.2 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII72817.1 - 0.1 12.4 2.8 10 6.0 0.1 3.3 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.1 KII72817.1 - 0.32 11.0 3.6 2.1 8.4 0.5 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.1 KII72818.1 - 2.7e-17 62.0 4.7 5.3e-05 23.2 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII72818.1 - 4.2e-14 51.8 3.9 7.6e-05 22.1 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII72818.1 - 8.1e-13 47.9 4.1 0.00039 20.1 0.1 3.3 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII72818.1 - 3.5e-12 46.1 2.6 0.0062 16.6 0.0 3.8 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII72818.1 - 3.3e-05 23.7 3.1 0.82 9.6 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII72818.1 - 0.0001 21.9 1.5 4.5 7.1 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Rax2 PF12768.2 KII72818.1 - 0.032 13.4 1.8 1.4 8.0 0.4 2.2 1 1 1 2 2 2 0 Cortical protein marker for cell polarity Kelch_6 PF13964.1 KII72819.1 - 6.4e-13 48.2 13.6 0.00025 21.0 0.0 6.1 5 1 0 6 6 6 3 Kelch motif Kelch_4 PF13418.1 KII72819.1 - 1.1e-09 37.8 3.7 0.021 14.5 0.0 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII72819.1 - 8.8e-06 25.1 17.1 0.07 12.6 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.1 KII72819.1 - 1.7e-05 24.8 4.0 0.47 10.7 0.1 5.2 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII72819.1 - 5e-05 22.8 9.6 2.5 7.9 0.0 5.6 6 0 0 6 6 6 3 Kelch motif SMI1_KNR4 PF09346.5 KII72819.1 - 0.028 14.4 0.2 0.068 13.1 0.1 1.7 2 0 0 2 2 2 0 SMI1 / KNR4 family (SUKH-1) Kelch_5 PF13854.1 KII72819.1 - 0.52 10.3 11.7 12 5.9 0.1 4.4 5 0 0 5 5 5 0 Kelch motif Ubiquitin_3 PF14836.1 KII72821.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain P22_Cro PF14549.1 KII72822.1 - 0.00051 19.7 0.0 0.0019 17.8 0.0 1.8 2 0 0 2 2 2 1 DNA-binding transcriptional regulator Cro Dynein_light PF01221.13 KII72822.1 - 0.1 12.5 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Dynein light chain type 1 CHCH PF06747.8 KII72823.1 - 4.3e-05 23.2 0.9 6.6e-05 22.7 0.7 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.5 KII72823.1 - 0.011 15.4 0.9 0.022 14.5 0.6 1.4 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.8 KII72823.1 - 0.072 12.5 0.3 0.11 11.9 0.2 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Hairy_orange PF07527.8 KII72823.1 - 0.13 12.0 0.2 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 Hairy Orange DDE_3 PF13358.1 KII72824.1 - 0.00012 21.8 1.8 0.0054 16.4 1.2 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.2 KII72825.1 - 0.00032 20.5 0.0 0.00043 20.1 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain BNR PF02012.15 KII72826.1 - 0.059 13.2 0.1 5.5 7.2 0.0 2.7 2 0 0 2 2 2 0 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII72827.1 - 1.6e-07 31.1 9.2 1.6e-07 31.1 6.4 2.9 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII72828.1 - 7.2e-07 29.0 12.3 7.2e-07 29.0 8.5 3.6 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A DDE_Tnp_IS1595 PF12762.2 KII72830.1 - 9.9e-07 28.7 0.0 1.2e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain HAP1_N PF04849.8 KII72832.1 - 0.00015 20.8 17.5 0.00072 18.6 10.9 2.1 1 1 1 2 2 2 1 HAP1 N-terminal conserved region DUF1474 PF07342.6 KII72832.1 - 0.00017 21.7 4.5 0.00024 21.2 2.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1474) BAG PF02179.11 KII72832.1 - 0.023 14.8 2.7 0.33 11.0 0.0 3.2 2 1 0 2 2 2 0 BAG domain IncA PF04156.9 KII72832.1 - 0.13 11.8 14.4 0.24 10.9 10.0 1.4 1 0 0 1 1 1 0 IncA protein DUF334 PF03904.8 KII72832.1 - 0.14 11.4 12.0 0.23 10.7 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF334) DUF4240 PF14024.1 KII72832.1 - 0.15 11.9 2.6 0.2 11.5 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4240) DUF3450 PF11932.3 KII72832.1 - 0.18 11.0 16.8 0.4 9.9 5.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Alpha-E PF04168.7 KII72832.1 - 0.22 10.8 5.6 1.2 8.4 0.9 2.1 1 1 1 2 2 2 0 A predicted alpha-helical domain with a conserved ER motif. DivIC PF04977.10 KII72832.1 - 0.33 10.4 17.3 0.49 9.9 1.6 3.5 2 1 1 3 3 3 0 Septum formation initiator DUF2935 PF11155.3 KII72832.1 - 0.49 10.4 11.9 0.3 11.1 4.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) H-kinase_dim PF02895.9 KII72832.1 - 0.88 9.9 8.0 0.84 10.0 1.1 2.9 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain DivIVA PF05103.8 KII72832.1 - 1 9.3 18.2 3.1 7.8 3.3 2.5 1 1 1 2 2 2 0 DivIVA protein DUF4140 PF13600.1 KII72832.1 - 1.2 9.5 10.2 2.5 8.5 0.4 3.2 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DASH_Dam1 PF08653.5 KII72832.1 - 1.5 8.6 7.8 2.7 7.8 0.3 2.8 3 0 0 3 3 3 0 DASH complex subunit Dam1 AcylCoA_dehyd_C PF12186.3 KII72832.1 - 1.5 8.6 8.2 3.2 7.6 0.8 3.0 1 1 2 3 3 3 0 Acyl-CoA dehydrogenase C terminal DUF342 PF03961.8 KII72832.1 - 1.9 6.8 15.7 0.36 9.1 5.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DFF-C PF09033.5 KII72832.1 - 3.1 7.6 10.3 1.9 8.3 5.6 1.8 2 1 0 2 2 1 0 DNA Fragmentation factor 45kDa, C terminal domain DUF3552 PF12072.3 KII72832.1 - 3.4 6.8 18.9 0.14 11.3 4.0 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF3552) Baculo_PEP_C PF04513.7 KII72832.1 - 4 7.2 6.1 2.5 7.8 2.2 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 KII72832.1 - 4.7 7.1 5.6 9.7 6.1 1.6 2.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF2924 PF11149.3 KII72832.1 - 8 6.4 8.6 2.3 8.2 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2924) SieB PF14163.1 KII72832.1 - 8.2 5.9 10.7 1.4 8.4 1.6 2.6 1 1 1 2 2 2 0 Superinfection exclusion protein B PolyA_pol PF01743.15 KII72834.1 - 0.051 13.7 0.5 0.067 13.4 0.3 1.3 1 0 0 1 1 1 0 Poly A polymerase head domain SCO1-SenC PF02630.9 KII72834.1 - 0.1 12.2 0.0 0.22 11.1 0.0 1.3 1 1 0 1 1 1 0 SCO1/SenC NUC153 PF08159.7 KII72834.1 - 0.15 11.6 0.7 0.51 9.9 0.5 1.9 1 0 0 1 1 1 0 NUC153 domain SpoIIE PF07228.7 KII72835.1 - 1.5e-12 47.6 0.0 2.9e-12 46.7 0.0 1.5 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 KII72835.1 - 4.1e-08 32.9 0.0 0.00079 18.8 0.0 2.5 2 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 KII72835.1 - 0.0026 17.1 0.0 0.0056 16.1 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.20 KII72836.1 - 1.1e-64 218.1 0.0 1.3e-64 217.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII72836.1 - 4.5e-38 130.7 0.0 5.7e-38 130.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII72836.1 - 7.6e-08 31.6 0.0 1.1e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KII72836.1 - 0.0014 18.3 0.0 0.0028 17.4 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 KII72836.1 - 0.0062 15.9 0.1 0.078 12.3 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Seadorna_VP7 PF07387.6 KII72836.1 - 0.011 14.5 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Abi_2 PF07751.6 KII72836.1 - 0.025 14.7 0.1 0.088 12.9 0.0 1.9 2 1 0 2 2 2 0 Abi-like protein Meleagrin PF08189.6 KII72836.1 - 0.095 12.1 1.7 0.13 11.7 0.1 2.0 2 0 0 2 2 2 0 Meleagrin/Cygnin family HTH_32 PF13565.1 KII72837.1 - 0.0011 19.7 0.0 0.0045 17.7 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.1 KII72837.1 - 0.046 12.9 0.0 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.1 KII72837.1 - 0.14 12.2 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain ERF PF04404.7 KII72838.1 - 0.048 13.2 0.1 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 ERF superfamily cNMP_binding PF00027.24 KII72839.1 - 1.2e-20 73.0 0.0 2.7e-11 43.1 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Patatin PF01734.17 KII72839.1 - 1.8e-15 57.3 2.8 6.3e-15 55.6 1.9 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase Pkinase PF00069.20 KII72840.1 - 3.2e-24 85.5 0.1 3.8e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII72840.1 - 8.5e-06 25.0 0.0 1.3e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KII72840.1 - 0.024 13.6 0.0 0.036 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KII72840.1 - 0.026 14.2 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KII72840.1 - 0.058 12.7 0.0 0.44 9.8 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Kinase-like PF14531.1 KII72840.1 - 0.1 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RVP PF00077.15 KII72841.1 - 1.5e-05 24.8 0.0 3.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII72841.1 - 0.091 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Mito_carr PF00153.22 KII72842.1 - 1.7e-65 216.7 4.7 2.1e-21 75.4 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF377 PF04041.8 KII72843.1 - 0.08 11.6 0.0 0.089 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF377) ADK PF00406.17 KII72847.1 - 1.3e-38 132.2 0.0 1.6e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KII72847.1 - 1.4e-14 53.4 0.0 2.9e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.1 KII72847.1 - 8.9e-10 38.9 0.0 1.7e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII72847.1 - 1.7e-09 38.5 0.1 3.3e-09 37.5 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KII72847.1 - 5.7e-05 23.0 0.0 9.4e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 KII72847.1 - 0.00029 21.0 0.0 0.00082 19.5 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 KII72847.1 - 0.022 13.8 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.1 KII72847.1 - 0.025 14.5 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.7 KII72847.1 - 0.05 12.6 0.0 0.1 11.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus tRNA_lig_kinase PF08303.6 KII72847.1 - 0.063 13.1 0.0 0.19 11.5 0.0 1.9 1 1 0 1 1 1 0 tRNA ligase kinase domain Med22 PF06179.7 KII72848.1 - 3.1e-05 23.9 3.0 3.8e-05 23.6 2.1 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex DHC_N1 PF08385.7 KII72848.1 - 0.045 12.1 4.5 0.051 11.9 3.1 1.0 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 BNR PF02012.15 KII72850.1 - 3.5e-07 29.0 3.0 0.11 12.3 0.1 4.0 3 0 0 3 3 3 3 BNR/Asp-box repeat BNR PF02012.15 KII72853.1 - 6.1e-05 22.2 6.4 4.5 7.4 0.0 4.6 4 0 0 4 4 4 4 BNR/Asp-box repeat Ldl_recept_a PF00057.13 KII72855.1 - 2.6e-09 36.8 8.9 2.6e-09 36.8 6.1 4.9 4 1 1 5 5 5 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII72857.1 - 0.00052 19.4 1.4 8.4 6.6 0.0 4.7 4 0 0 4 4 4 2 BNR/Asp-box repeat BNR PF02012.15 KII72859.1 - 5.7e-05 22.3 4.1 0.042 13.6 0.0 4.3 4 0 0 4 4 4 2 BNR/Asp-box repeat Hat1_N PF10394.4 KII72863.1 - 0.012 15.6 0.2 0.013 15.5 0.1 1.2 1 0 0 1 1 1 0 Histone acetyl transferase HAT1 N-terminus Pox_E10 PF04805.7 KII72863.1 - 0.094 12.2 0.5 0.15 11.5 0.3 1.3 1 0 0 1 1 1 0 E10-like protein conserved region BNR PF02012.15 KII72864.1 - 1.7e-05 23.9 0.2 1.1 9.4 0.0 3.9 3 0 0 3 3 3 3 BNR/Asp-box repeat BNR PF02012.15 KII72865.1 - 0.15 11.9 0.4 0.15 11.9 0.3 2.5 3 0 0 3 3 3 0 BNR/Asp-box repeat DUF4215 PF13948.1 KII72867.1 - 0.081 13.1 0.4 0.2 11.9 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) Kunitz_BPTI PF00014.18 KII72874.1 - 7.6e-11 42.0 16.1 3.6e-10 39.8 6.7 2.4 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Actin PF00022.14 KII72875.1 - 8.6e-160 531.4 0.0 9.8e-160 531.2 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 KII72875.1 - 0.075 13.4 0.0 0.19 12.1 0.0 1.7 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Actin PF00022.14 KII72876.1 - 5.4e-125 416.8 0.0 6.2e-125 416.6 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 KII72876.1 - 4.8e-05 22.1 0.0 0.00055 18.6 0.0 2.3 1 1 0 1 1 1 1 MreB/Mbl protein KaiA PF07688.7 KII72876.1 - 0.014 14.6 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 KaiA domain TetR_C_8 PF14278.1 KII72879.1 - 0.12 12.7 6.9 24 5.4 0.3 3.3 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region PRRSV_2b PF07069.6 KII72880.1 - 0.021 15.1 0.1 0.041 14.1 0.1 1.4 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b DUF4381 PF14316.1 KII72880.1 - 0.072 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF3180 PF11377.3 KII72880.1 - 0.087 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3180) DUF4389 PF14333.1 KII72880.1 - 0.21 11.3 2.1 0.52 10.0 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) Annexin PF00191.15 KII72881.1 - 2.4e-05 24.1 0.0 0.0065 16.3 0.0 2.3 2 0 0 2 2 2 2 Annexin Annexin PF00191.15 KII72884.1 - 2.3e-19 69.0 1.7 1.3e-08 34.6 0.0 3.4 3 0 0 3 3 3 3 Annexin VCBS PF13517.1 KII72886.1 - 7.1e-06 26.2 1.0 3.2e-05 24.2 0.7 2.2 1 1 0 1 1 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII72886.1 - 0.0075 15.9 3.4 0.038 13.6 0.0 2.7 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.1 KII72887.1 - 0.075 13.4 0.1 0.19 12.1 0.1 1.7 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII72887.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 FG-GAP repeat DUF3501 PF12007.3 KII72888.1 - 0.04 13.6 0.0 0.048 13.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3501) Annexin PF00191.15 KII72890.1 - 0.0077 16.1 2.9 2.3 8.1 0.1 3.0 1 1 2 3 3 3 2 Annexin Ribosomal_S10 PF00338.17 KII72890.1 - 0.052 13.4 0.1 0.12 12.2 0.1 1.6 1 1 0 1 1 1 0 Ribosomal protein S10p/S20e DRIM PF07539.7 KII72893.1 - 0.012 15.0 0.4 0.052 12.9 0.1 2.0 2 0 0 2 2 2 0 Down-regulated in metastasis Usg PF06233.7 KII72893.1 - 0.12 12.3 0.1 0.84 9.5 0.0 2.2 2 0 0 2 2 2 0 Usg-like family Serpin PF00079.15 KII72894.1 - 9.9e-46 156.5 5.3 1.1e-45 156.3 3.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Annexin PF00191.15 KII72895.1 - 3.7e-06 26.7 3.4 0.004 17.0 0.4 3.5 3 0 0 3 3 3 2 Annexin Annexin PF00191.15 KII72898.1 - 3.9e-12 45.8 0.5 1.4e-07 31.2 0.0 2.6 2 0 0 2 2 2 2 Annexin Annexin PF00191.15 KII72899.1 - 1.2e-18 66.7 4.8 6.7e-11 41.9 0.1 3.8 4 0 0 4 4 4 3 Annexin DDE_3 PF13358.1 KII72901.1 - 8.9e-11 41.7 0.0 1.1e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Phytoreo_P8 PF07124.6 KII72901.1 - 0.0027 16.4 0.0 0.0029 16.3 0.0 1.0 1 0 0 1 1 1 1 Phytoreovirus outer capsid protein P8 RVT_1 PF00078.22 KII72903.1 - 0.00076 18.9 0.0 0.0018 17.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med14 PF08638.6 KII72903.1 - 0.048 12.8 0.1 0.29 10.3 0.0 2.0 2 0 0 2 2 2 0 Mediator complex subunit MED14 DDE_Tnp_IS1595 PF12762.2 KII72904.1 - 1.7e-11 44.1 0.1 4.1e-10 39.6 0.0 2.1 1 1 1 2 2 2 1 ISXO2-like transposase domain zf-RING_4 PF14570.1 KII72904.1 - 0.089 12.3 2.6 0.096 12.2 0.8 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RecR PF02132.10 KII72904.1 - 0.45 9.9 4.4 0.87 9.0 3.1 1.4 1 0 0 1 1 1 0 RecR protein TraS PF10624.4 KII72905.1 - 0.00061 19.3 4.1 0.00061 19.3 2.9 1.9 1 1 1 2 2 2 1 Plasmid conjugative transfer entry exclusion protein TraS GWT1 PF06423.7 KII72905.1 - 0.016 15.3 1.4 0.016 15.3 1.0 2.5 1 1 0 3 3 3 0 GWT1 Claudin_2 PF13903.1 KII72905.1 - 0.47 10.1 9.7 1.7 8.2 6.7 2.1 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.15 KII72905.1 - 0.95 9.0 9.0 0.12 11.9 2.3 2.2 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family ARL6IP6 PF15062.1 KII72906.1 - 0.015 15.2 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix Annexin PF00191.15 KII72908.1 - 3.7e-19 68.3 3.5 1.2e-11 44.3 0.1 3.2 3 0 0 3 3 3 2 Annexin Prok-RING_4 PF14447.1 KII72908.1 - 0.0086 15.6 0.4 0.017 14.6 0.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF515 PF04415.7 KII72908.1 - 0.035 12.3 0.4 0.044 12.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) zf-RING_5 PF14634.1 KII72908.1 - 0.058 13.1 5.3 0.16 11.7 3.6 1.8 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KII72908.1 - 3.6 7.6 6.7 14 5.7 4.6 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Annexin PF00191.15 KII72910.1 - 3.2e-19 68.6 7.1 6.9e-10 38.6 0.1 3.4 2 1 1 3 3 3 3 Annexin Muskelin_N PF06588.6 KII72910.1 - 0.00081 19.1 2.6 0.0014 18.3 1.8 1.3 1 0 0 1 1 1 1 Muskelin N-terminus Takusan PF04822.8 KII72914.1 - 0.015 15.0 0.5 0.032 14.0 0.4 1.5 1 0 0 1 1 1 0 Takusan Serpin PF00079.15 KII72915.1 - 2.7e-23 82.6 0.3 3.2e-23 82.4 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RSS_P20 PF11757.3 KII72915.1 - 0.11 12.5 0.6 0.24 11.5 0.4 1.6 1 1 1 2 2 2 0 Suppressor of RNA silencing P21-like Serpin PF00079.15 KII72916.1 - 6.6e-18 64.9 0.8 2.4e-17 63.1 0.5 1.7 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Nop14 PF04147.7 KII72916.1 - 0.0018 16.3 19.8 0.002 16.1 13.7 1.0 1 0 0 1 1 1 1 Nop14-like family Hid1 PF12722.2 KII72916.1 - 0.016 12.8 4.5 0.017 12.8 3.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ycf1 PF05758.7 KII72916.1 - 0.024 12.3 8.2 0.027 12.2 5.7 1.0 1 0 0 1 1 1 0 Ycf1 TFIIA PF03153.8 KII72916.1 - 0.037 13.9 18.5 0.037 13.9 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tim54 PF11711.3 KII72916.1 - 0.049 12.2 7.1 0.065 11.8 4.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2146 PF10220.4 KII72916.1 - 0.049 11.6 11.7 0.059 11.3 8.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) DDHD PF02862.12 KII72916.1 - 0.054 13.2 3.8 0.059 13.1 2.6 1.1 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.9 KII72916.1 - 0.082 10.9 16.8 0.093 10.7 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.1 KII72916.1 - 0.11 11.7 6.5 0.12 11.6 4.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Zip PF02535.17 KII72916.1 - 0.17 10.8 0.2 0.15 10.9 0.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1510 PF07423.6 KII72916.1 - 0.22 10.8 19.8 0.29 10.4 13.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CobT PF06213.7 KII72916.1 - 0.3 10.1 22.1 0.35 9.9 15.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Gti1_Pac2 PF09729.4 KII72916.1 - 0.31 10.8 3.2 0.42 10.4 2.2 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Vfa1 PF08432.5 KII72916.1 - 0.4 10.6 11.8 0.55 10.2 8.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SAPS PF04499.10 KII72916.1 - 0.46 9.0 9.4 0.61 8.6 6.5 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.7 KII72916.1 - 0.55 10.0 11.1 0.66 9.8 7.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spore_coat_CotO PF14153.1 KII72916.1 - 0.57 9.5 11.6 0.89 8.9 8.0 1.3 1 0 0 1 1 1 0 Spore coat protein CotO RRN3 PF05327.6 KII72916.1 - 0.95 7.4 15.0 1.2 7.1 10.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sec62 PF03839.11 KII72916.1 - 1.1 8.5 3.7 1.5 8.2 2.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2201_N PF13203.1 KII72916.1 - 1.2 8.2 6.9 1.4 8.0 4.8 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain SDA1 PF05285.7 KII72916.1 - 1.5 7.9 26.1 2 7.6 18.1 1.1 1 0 0 1 1 1 0 SDA1 RP-C_C PF11800.3 KII72916.1 - 1.6 8.3 6.6 2.3 7.8 4.6 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region NPR3 PF03666.8 KII72916.1 - 2.1 6.7 7.6 2.5 6.5 5.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BUD22 PF09073.5 KII72916.1 - 3.3 6.6 21.3 3.9 6.4 14.8 1.1 1 0 0 1 1 1 0 BUD22 DUF3408 PF11888.3 KII72916.1 - 3.5 7.5 10.6 5.5 6.9 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) YqfQ PF14181.1 KII72916.1 - 3.6 7.5 11.7 5.4 7.0 8.1 1.2 1 0 0 1 1 1 0 YqfQ-like protein CKAP2_C PF15297.1 KII72916.1 - 3.8 6.2 11.9 4.9 5.8 8.3 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Daxx PF03344.10 KII72916.1 - 8.2 4.7 27.6 10 4.4 19.1 1.0 1 0 0 1 1 1 0 Daxx Family DUF2722 PF10846.3 KII72916.1 - 8.9 5.2 13.6 11 4.8 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Nop25 PF09805.4 KII72916.1 - 9.6 6.2 19.6 14 5.7 13.6 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) rve PF00665.21 KII72917.1 - 7.9e-21 74.3 0.0 1.9e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII72917.1 - 4.7e-17 62.0 0.0 1.3e-16 60.6 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII72917.1 - 1.2e-05 24.7 0.4 8.8e-05 21.9 0.0 2.7 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.18 KII72917.1 - 3 7.9 16.5 0.25 11.3 4.6 2.9 2 0 0 2 2 2 0 Zinc knuckle PRP3 PF08572.5 KII72922.1 - 0.0093 15.3 0.8 0.014 14.8 0.5 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) Bromo_TP PF07524.8 KII72923.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated Ldh_1_N PF00056.18 KII72924.1 - 7.5e-09 35.5 0.0 1.1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Gly_kinase PF02595.10 KII72924.1 - 0.0093 14.6 0.1 0.01 14.5 0.1 1.1 1 0 0 1 1 1 1 Glycerate kinase family Semialdhyde_dh PF01118.19 KII72924.1 - 0.13 12.6 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Arg_repressor PF01316.16 KII72925.1 - 7.1e-26 89.5 0.1 1.1e-25 88.9 0.1 1.3 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain Arg_repressor_C PF02863.13 KII72925.1 - 5.1e-23 80.3 0.1 8.1e-23 79.6 0.1 1.3 1 0 0 1 1 1 1 Arginine repressor, C-terminal domain DUF2114 PF09887.4 KII72925.1 - 0.025 12.9 0.0 0.1 10.9 0.0 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2114) HTH_32 PF13565.1 KII72925.1 - 0.095 13.5 0.0 0.29 11.9 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain DUF1471 PF07338.8 KII72926.1 - 2.9e-27 94.0 0.6 7e-19 67.2 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1471) HNF-1B_C PF04812.8 KII72926.1 - 0.023 14.0 6.0 0.43 9.8 1.2 2.1 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus SOR_SNZ PF01680.12 KII72926.1 - 0.028 14.0 2.3 3.1 7.3 0.2 2.2 2 0 0 2 2 2 0 SOR/SNZ family FadA PF09403.5 KII72926.1 - 0.061 13.3 1.3 2.6 8.0 0.1 2.3 2 0 0 2 2 2 0 Adhesion protein FadA DUF3316 PF11777.3 KII72926.1 - 0.12 12.1 1.3 3.5 7.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3316) BPD_transp_2 PF02653.11 KII72929.1 - 0.0015 17.5 0.1 0.0016 17.4 0.1 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Shisa PF13908.1 KII72929.1 - 0.0036 17.5 0.4 0.0045 17.1 0.3 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator IncA PF04156.9 KII72929.1 - 0.0073 15.9 0.1 0.0083 15.7 0.0 1.1 1 0 0 1 1 1 1 IncA protein EVC2_like PF12297.3 KII72929.1 - 0.012 14.2 0.8 0.013 14.1 0.5 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Pex24p PF06398.6 KII72929.1 - 0.017 13.9 1.1 0.018 13.8 0.7 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF2244 PF10003.4 KII72929.1 - 0.018 14.4 1.5 0.022 14.1 1.0 1.1 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Tic20 PF09685.5 KII72929.1 - 0.032 14.1 10.0 0.042 13.8 6.9 1.2 1 0 0 1 1 1 0 Tic20-like protein Herpes_gE PF02480.11 KII72929.1 - 0.034 12.4 0.1 0.039 12.2 0.1 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Corona_S2 PF01601.11 KII72929.1 - 0.058 11.4 0.8 0.062 11.3 0.6 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF1512 PF07431.7 KII72929.1 - 0.11 11.2 1.2 0.13 10.9 0.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) GP41 PF00517.12 KII72929.1 - 0.16 11.4 1.2 0.19 11.2 0.8 1.2 1 0 0 1 1 1 0 Retroviral envelope protein HemY_N PF07219.8 KII72929.1 - 0.21 11.1 5.3 0.29 10.7 3.7 1.2 1 0 0 1 1 1 0 HemY protein N-terminus DUF4446 PF14584.1 KII72929.1 - 0.31 10.8 1.5 0.41 10.4 1.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) ELF PF03317.8 KII72929.1 - 0.43 9.8 7.3 0.47 9.7 5.0 1.1 1 0 0 1 1 1 0 ELF protein MLANA PF14991.1 KII72929.1 - 0.58 10.1 3.8 1.2 9.1 2.6 1.6 1 1 0 1 1 1 0 Protein melan-A DUF4191 PF13829.1 KII72929.1 - 0.61 9.1 7.0 0.8 8.7 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF3481 PF11980.3 KII72929.1 - 0.98 9.2 3.2 1.2 9.0 2.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3481) CbiQ PF02361.11 KII72929.1 - 1.6 8.2 8.3 1.9 8.0 5.8 1.1 1 0 0 1 1 1 0 Cobalt transport protein MMPL PF03176.10 KII72929.1 - 3.1 6.4 9.3 4.4 5.9 6.4 1.2 1 0 0 1 1 1 0 MMPL family Luciferase_N PF05295.6 KII72932.1 - 0.047 13.4 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain Neur_chan_memb PF02932.11 KII72932.1 - 3.1 7.6 4.5 4.5 7.0 3.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TFIIA PF03153.8 KII72932.1 - 9.5 5.9 9.9 13 5.5 6.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PH_8 PF15409.1 KII72935.1 - 0.1 12.7 0.0 0.26 11.3 0.0 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain rve PF00665.21 KII72937.1 - 4.8e-10 39.5 0.5 1.1e-09 38.3 0.1 1.8 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII72937.1 - 0.0038 16.6 0.4 1.5 8.1 0.0 2.7 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Serpin PF00079.15 KII72938.1 - 4.1e-23 82.1 1.2 4.4e-23 82.0 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4230 PF14014.1 KII72938.1 - 0.038 13.8 0.3 0.06 13.2 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4230) Phage_T7_tail PF03906.9 KII72938.1 - 0.057 13.0 0.6 0.16 11.6 0.1 1.9 2 0 0 2 2 2 0 Phage T7 tail fibre protein EF-hand_2 PF09068.6 KII72938.1 - 0.093 12.8 0.1 0.12 12.4 0.1 1.2 1 0 0 1 1 1 0 EF hand SWIRM PF04433.12 KII72939.1 - 0.029 14.4 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 SWIRM domain DUF1978 PF09321.5 KII72939.1 - 0.049 13.0 0.1 0.053 12.9 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) DUF2842 PF11003.3 KII72940.1 - 2.9 7.8 4.9 0.8 9.6 0.7 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2842) DDE_3 PF13358.1 KII72943.1 - 6.7e-06 25.9 0.1 7.8e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_6 PF13964.1 KII72944.1 - 4.6e-12 45.5 3.8 0.096 12.8 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 KII72944.1 - 2.2e-10 40.1 8.4 0.00075 19.2 0.0 5.4 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII72944.1 - 3e-09 36.7 3.6 0.0011 19.0 0.0 5.2 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII72944.1 - 2e-07 30.4 3.7 0.047 13.4 0.0 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.20 KII72944.1 - 2.7e-05 23.6 3.9 1.4 8.5 0.1 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.1 KII72944.1 - 0.004 17.0 1.6 4.9 7.2 0.0 4.0 5 0 0 5 5 5 2 Kelch motif T4_tail_cap PF11091.3 KII72945.1 - 0.046 12.4 0.0 0.06 12.0 0.0 1.1 1 0 0 1 1 1 0 Tail-tube assembly protein T2SE PF00437.15 KII72946.1 - 0.0019 17.1 0.0 0.0019 17.1 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.1 KII72946.1 - 0.0021 17.5 0.0 0.0035 16.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain UPF0079 PF02367.12 KII72946.1 - 0.0062 16.1 0.0 0.009 15.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 ABC_tran PF00005.22 KII72946.1 - 0.0093 16.2 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ResIII PF04851.10 KII72946.1 - 0.0097 15.7 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_24 PF13479.1 KII72946.1 - 0.012 15.1 0.1 0.02 14.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.7 KII72946.1 - 0.013 14.8 0.3 0.019 14.2 0.2 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_23 PF13476.1 KII72946.1 - 0.073 13.3 0.1 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 KII72946.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family PhoH PF02562.11 KII72946.1 - 0.12 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.1 KII72946.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KII72946.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain DUF258 PF03193.11 KII72946.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 KII72946.1 - 0.14 12.1 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain BDV_P24 PF06595.6 KII72947.1 - 0.034 13.9 0.5 0.043 13.5 0.3 1.1 1 0 0 1 1 1 0 Borna disease virus P24 protein HJURP_C PF12347.3 KII72947.1 - 0.042 13.4 0.9 0.075 12.6 0.2 1.8 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat DUF3473 PF11959.3 KII72947.1 - 0.08 12.3 0.2 0.46 9.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3473) DUF1104 PF06518.6 KII72947.1 - 0.086 12.9 5.1 0.33 11.1 1.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1104) Ferrochelatase PF00762.14 KII72950.1 - 0.017 14.0 0.1 0.054 12.4 0.0 1.7 1 1 0 1 1 1 0 Ferrochelatase Rad17 PF03215.10 KII72950.1 - 0.019 13.6 0.3 0.022 13.4 0.2 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Fe_hyd_SSU PF02256.12 KII72950.1 - 0.037 14.0 0.2 0.1 12.6 0.2 1.7 1 0 0 1 1 1 0 Iron hydrogenase small subunit Fibrinogen_BP PF08017.6 KII72952.1 - 0.024 12.8 44.4 0.79 7.8 19.7 2.6 1 1 1 2 2 2 0 Fibrinogen binding protein Fibrinogen_BP PF08017.6 KII72953.1 - 0.036 12.2 40.9 0.14 10.3 6.7 2.0 1 1 0 2 2 2 0 Fibrinogen binding protein SNAP PF14938.1 KII72954.1 - 9.6e-13 47.9 3.1 1.3e-12 47.5 2.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII72954.1 - 0.002 17.7 2.8 0.0031 17.1 1.9 1.3 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 KII72954.1 - 0.028 14.3 6.3 0.8 9.7 0.4 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KII72954.1 - 0.037 13.9 0.8 0.057 13.3 0.5 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat NSF PF02071.15 KII72954.1 - 0.12 12.9 7.5 11 7.0 0.3 4.3 3 2 2 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.1 KII72954.1 - 0.13 12.0 3.3 4.2 7.3 0.6 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KII72954.1 - 0.3 11.6 2.5 5.8 7.6 0.1 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII72954.1 - 0.49 10.0 7.3 11 5.8 0.2 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.1 KII72955.1 - 7.3e-05 23.2 0.1 0.00012 22.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily P4Ha_N PF08336.6 KII72956.1 - 2.2e-15 56.6 0.0 3.5e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SCF PF02404.10 KII72956.1 - 0.004 16.4 0.1 0.0055 15.9 0.0 1.2 1 0 0 1 1 1 1 Stem cell factor Kunitz_BPTI PF00014.18 KII72962.1 - 0.0022 18.1 18.0 0.03 14.5 5.1 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Kunitz_BPTI PF00014.18 KII72963.1 - 5.4e-07 29.7 17.9 8.2e-05 22.7 6.3 2.7 3 0 0 3 3 3 2 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF3479 PF11965.3 KII72964.1 - 0.047 13.4 0.1 0.14 11.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3479) PCAF_N PF06466.6 KII72964.1 - 0.063 12.5 0.1 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 PCAF (P300/CBP-associated factor) N-terminal domain Homeobox PF00046.24 KII72968.1 - 3.3e-17 61.8 0.7 5.2e-17 61.2 0.5 1.3 1 0 0 1 1 1 1 Homeobox domain MRP-63 PF14978.1 KII72968.1 - 0.084 13.3 0.5 0.15 12.5 0.3 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome protein 63 CENP-B_N PF04218.8 KII72968.1 - 0.086 12.2 0.1 0.27 10.6 0.0 1.8 1 1 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_26 PF13443.1 KII72968.1 - 0.14 12.4 0.1 0.71 10.1 0.0 2.1 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Ribosomal_S3_C PF00189.15 KII72969.1 - 2.9e-15 56.2 0.4 7.5e-15 54.9 0.5 1.5 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 KII72969.1 - 5.4e-05 22.6 0.0 0.00011 21.7 0.0 1.5 1 0 0 1 1 1 1 KH domain Glyco_transf_10 PF00852.14 KII72971.1 - 2.9e-44 151.0 6.0 3.6e-44 150.7 4.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) ARPC4 PF05856.7 KII72971.1 - 0.028 13.8 0.0 0.066 12.5 0.0 1.6 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) Glycos_transf_2 PF00535.21 KII72974.1 - 0.00089 18.9 0.1 0.0015 18.2 0.1 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII72974.1 - 0.055 13.2 0.0 0.084 12.6 0.0 1.4 1 1 0 1 1 1 0 Glycosyltransferase like family 2 Hexokinase_2 PF03727.11 KII72975.1 - 4.8e-63 212.6 0.1 6.4e-63 212.2 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII72975.1 - 5.4e-55 185.9 0.0 7.4e-55 185.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase rpo30_N PF12410.3 KII72976.1 - 0.014 15.0 0.7 0.02 14.5 0.5 1.2 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit DDE_3 PF13358.1 KII72977.1 - 2.7e-20 72.6 0.1 3.6e-20 72.2 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII72977.1 - 0.059 13.4 0.0 0.086 12.9 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain DDE_1 PF03184.14 KII72977.1 - 0.073 12.1 0.0 0.081 12.0 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease XFP PF03894.10 KII72977.1 - 0.09 12.3 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Cyt-b5 PF00173.23 KII72978.1 - 7.7e-22 76.8 0.2 1e-21 76.5 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain UPF0203 PF05254.7 KII72979.1 - 3.6e-20 71.5 0.6 4.9e-20 71.1 0.5 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Cmc1 PF08583.5 KII72979.1 - 0.0056 16.4 1.8 0.54 10.0 0.1 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.11 KII72979.1 - 0.0099 15.8 0.3 0.41 10.6 0.1 2.3 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein CHCH PF06747.8 KII72979.1 - 0.015 15.2 0.3 0.015 15.2 0.2 2.0 2 0 0 2 2 2 0 CHCH domain DUF1762 PF08574.5 KII72979.1 - 0.057 13.8 0.1 0.11 12.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1762) COX17 PF05051.8 KII72979.1 - 0.21 11.6 1.6 0.71 9.9 1.1 1.9 1 1 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Myb_DNA-bind_6 PF13921.1 KII72982.1 - 1.7e-08 34.4 0.2 0.0022 18.0 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KII72982.1 - 2e-08 34.1 1.8 0.001 19.0 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Xin PF08043.7 KII72983.1 - 0.2 11.4 3.7 1.6 8.5 0.0 3.5 3 0 0 3 3 3 0 Xin repeat RVT_1 PF00078.22 KII72985.1 - 3.5e-16 59.2 0.3 6.9e-16 58.2 0.2 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII72987.1 - 1.2e-15 57.7 0.0 1.6e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII72987.1 - 0.00013 21.3 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII72987.1 - 0.0038 16.9 0.0 0.0042 16.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1796 PF08795.5 KII72990.1 - 0.0029 17.2 3.2 0.022 14.3 0.1 2.7 2 0 0 2 2 2 1 Putative papain-like cysteine peptidase (DUF1796) Mrr_cat PF04471.7 KII72990.1 - 0.029 14.1 0.0 0.08 12.7 0.0 1.7 1 0 0 1 1 1 0 Restriction endonuclease DUF2341 PF10102.4 KII72991.1 - 0.23 11.6 1.5 7.1 6.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF2341) DUF572 PF04502.8 KII72992.1 - 0.011 14.9 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SNAP PF14938.1 KII72994.1 - 5.8e-13 48.6 1.1 8.2e-13 48.1 0.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII72994.1 - 2.9e-05 23.8 2.9 0.008 16.0 0.6 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII72994.1 - 0.014 15.3 2.6 0.025 14.4 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII72994.1 - 0.043 13.6 1.0 0.32 10.8 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.13 KII72994.1 - 0.19 11.6 3.3 2.1 8.2 0.2 2.6 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 KII72994.1 - 0.35 10.5 5.1 0.36 10.5 0.9 2.3 2 1 0 2 2 2 0 TPR repeat VPR PF00522.13 KII72995.1 - 0.08 12.7 0.2 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 VPR/VPX protein PFL PF02901.10 KII72996.1 - 0.072 11.5 0.1 0.072 11.5 0.0 1.0 1 0 0 1 1 1 0 Pyruvate formate lyase ADH_zinc_N PF00107.21 KII73001.1 - 0.013 14.9 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 Zinc-binding dehydrogenase ADH_N PF08240.7 KII73002.1 - 4.9e-07 29.4 0.0 6.1e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain FLYWCH PF04500.11 KII73004.1 - 1.2e-14 53.8 4.3 3.2e-14 52.5 3.0 1.7 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 KII73004.1 - 9.6e-11 41.7 0.0 7.3e-09 35.6 0.0 2.5 2 0 0 2 2 2 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.12 KII73004.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Transposase Zn_ribbon_recom PF13408.1 KII73004.1 - 0.37 11.1 6.9 0.78 10.0 4.8 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF1616 PF07760.6 KII73009.1 - 0.079 12.0 2.7 0.95 8.5 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) S1FA PF04689.8 KII73012.1 - 0.12 12.2 0.5 0.27 11.1 0.4 1.6 1 0 0 1 1 1 0 DNA binding protein S1FA Spin-Ssty PF02513.12 KII73013.1 - 0.016 14.7 0.1 0.054 13.0 0.0 1.8 2 0 0 2 2 2 0 Spin/Ssty Family Mucin PF01456.12 KII73016.1 - 0.025 14.3 10.0 0.035 13.8 6.9 1.3 1 1 0 1 1 1 0 Mucin-like glycoprotein DUF605 PF04652.11 KII73016.1 - 2 7.7 22.9 2.4 7.4 15.9 1.0 1 0 0 1 1 1 0 Vta1 like DUF4176 PF13780.1 KII73018.1 - 0.042 13.5 0.0 0.12 12.0 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4176) BNR PF02012.15 KII73021.1 - 0.0002 20.6 0.6 0.092 12.6 0.1 3.1 3 0 0 3 3 3 2 BNR/Asp-box repeat SNAP PF14938.1 KII73022.1 - 1.7e-07 30.6 3.5 2.1e-07 30.3 2.3 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.23 KII73022.1 - 0.0023 17.4 6.4 0.063 12.9 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII73022.1 - 0.0023 17.5 2.6 0.038 13.6 0.7 3.1 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 KII73022.1 - 0.049 13.5 2.2 4.8 7.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII73022.1 - 1.1 9.2 6.1 6.9 6.7 0.1 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat AbiH PF14253.1 KII73031.1 - 0.044 13.3 0.1 0.057 13.0 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH DUF4475 PF14753.1 KII73032.1 - 0.015 14.8 1.5 0.02 14.3 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4475) DDE_3 PF13358.1 KII73034.1 - 3.7e-18 65.6 0.0 4.4e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII73034.1 - 0.055 12.6 0.0 0.062 12.4 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Arm PF00514.18 KII73035.1 - 1.8e-21 75.1 3.1 0.0014 18.3 0.0 7.1 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KII73035.1 - 2.2e-11 43.8 0.0 0.00098 19.3 0.0 5.0 3 1 1 5 5 5 3 HEAT repeats HEAT_EZ PF13513.1 KII73035.1 - 3.1e-11 43.3 0.3 0.17 12.4 0.0 5.4 5 1 1 6 6 6 4 HEAT-like repeat IBB PF01749.15 KII73035.1 - 7.9e-11 41.9 0.5 1.7e-10 40.8 0.3 1.5 1 0 0 1 1 1 1 Importin beta binding domain HEAT PF02985.17 KII73035.1 - 8.4e-07 28.5 0.3 0.9 9.7 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat Arm_2 PF04826.8 KII73035.1 - 1.2e-05 24.5 6.9 0.001 18.2 0.3 3.2 3 0 0 3 3 3 2 Armadillo-like Ldl_recept_a PF00057.13 KII73038.1 - 2.5e-28 97.6 90.7 6.2e-10 38.8 11.7 5.3 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A DUF914 PF06027.7 KII73041.1 - 4.1e-17 62.0 5.9 4.6e-17 61.8 4.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 KII73041.1 - 0.0015 18.5 11.0 0.002 18.1 7.6 1.2 1 0 0 1 1 1 1 EamA-like transporter family DUF4389 PF14333.1 KII73041.1 - 0.016 14.9 1.2 0.043 13.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) TctB PF07331.6 KII73041.1 - 0.41 10.2 4.4 0.54 9.8 3.0 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF3671 PF12420.3 KII73041.1 - 3.8 7.5 6.9 12 5.9 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function Ninjurin PF04923.7 KII73041.1 - 6.1 6.6 7.7 0.65 9.7 0.2 2.5 1 1 2 3 3 3 0 Ninjurin DUF914 PF06027.7 KII73042.1 - 3.5e-09 35.9 5.1 4.4e-09 35.6 3.6 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EamA PF00892.15 KII73042.1 - 0.05 13.6 2.8 0.061 13.3 1.6 1.3 1 1 0 1 1 1 0 EamA-like transporter family RuBisCO_large_N PF02788.11 KII73043.1 - 0.055 13.1 0.0 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain SLBB PF10531.4 KII73044.1 - 0.00022 21.0 0.0 0.0004 20.2 0.0 1.4 1 0 0 1 1 1 1 SLBB domain Complex1_51K PF01512.12 KII73045.1 - 1.1e-37 129.1 0.0 1.4e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit DUF581 PF04570.9 KII73045.1 - 0.6 9.4 3.6 0.94 8.8 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF581) zf-CCHC PF00098.18 KII73046.1 - 2.1e-06 27.3 4.8 3.8e-06 26.5 3.3 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.1 KII73046.1 - 0.0011 18.5 0.8 0.0029 17.2 0.5 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 KII73046.1 - 0.0023 17.5 0.5 0.006 16.2 0.4 1.7 1 0 0 1 1 1 1 Zinc knuckle Fork_head PF00250.13 KII73047.1 - 7.7e-19 67.5 0.4 1.6e-18 66.4 0.3 1.5 1 0 0 1 1 1 1 Fork head domain Linker_histone PF00538.14 KII73047.1 - 0.011 15.7 0.1 0.087 12.9 0.0 2.2 2 0 0 2 2 2 0 linker histone H1 and H5 family MgsA_C PF12002.3 KII73047.1 - 0.1 12.2 0.2 2.3 7.8 0.0 2.1 2 0 0 2 2 2 0 MgsA AAA+ ATPase C terminal AMPKBI PF04739.10 KII73047.1 - 0.47 10.3 5.2 0.27 11.1 0.6 2.1 2 0 0 2 2 2 0 5'-AMP-activated protein kinase beta subunit, interation domain FLYWCH PF04500.11 KII73048.1 - 0.00073 19.3 2.1 0.0013 18.6 1.5 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain Hormone_4 PF00220.12 KII73048.1 - 0.44 10.3 4.3 2.2 8.1 0.2 2.5 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain Pentapeptide_4 PF13599.1 KII73049.1 - 0.0011 18.6 3.5 0.006 16.3 2.4 2.0 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) HC2 PF07382.6 KII73049.1 - 0.0032 17.3 1.3 0.0041 17.0 0.9 1.2 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Pentapeptide_3 PF13576.1 KII73049.1 - 0.0033 17.2 3.6 0.3 11.0 0.5 2.8 2 1 0 2 2 2 2 Pentapeptide repeats (9 copies) Toxin_62 PF15540.1 KII73049.1 - 0.067 13.3 4.4 0.16 12.0 0.7 2.1 1 1 1 2 2 2 0 Putative toxin 62 DUF2960 PF11173.3 KII73049.1 - 0.85 9.9 6.5 8.8 6.7 1.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2960) zf-Di19 PF05605.7 KII73049.1 - 0.89 9.7 3.1 7.5 6.7 0.0 2.8 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF2036 PF09724.4 KII73051.1 - 1.2e-38 133.1 0.3 1.5e-38 132.7 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) DUF2392 PF10288.4 KII73053.1 - 0.23 11.8 2.1 0.57 10.5 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2392) DNA_pol3_a_NII PF11490.3 KII73053.1 - 0.99 9.0 7.7 0.077 12.6 1.4 2.1 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II YTH PF04146.10 KII73054.1 - 2.4e-31 108.1 0.0 4.9e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 YT521-B-like domain Serpin PF00079.15 KII73055.1 - 1e-44 153.1 0.4 1.1e-44 153.0 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RVT_1 PF00078.22 KII73059.1 - 3e-27 95.4 1.1 5.2e-27 94.6 0.2 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII73059.1 - 2.7e-25 88.8 0.0 1.1e-24 86.8 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.1 KII73059.1 - 9.7e-07 29.2 0.1 7.8e-06 26.3 0.1 2.3 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.18 KII73059.1 - 8e-05 22.3 4.0 0.00027 20.7 2.8 2.0 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.15 KII73059.1 - 0.00064 19.5 0.0 0.0043 16.9 0.0 2.3 2 0 0 2 2 2 1 Retroviral aspartyl protease Retrotrans_gag PF03732.12 KII73059.1 - 0.00079 19.4 1.1 0.0019 18.2 0.1 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein RVP_2 PF08284.6 KII73059.1 - 0.012 15.5 0.0 0.068 13.1 0.0 2.2 2 0 0 2 2 2 0 Retroviral aspartyl protease rve_3 PF13683.1 KII73059.1 - 0.062 12.8 0.1 0.4 10.2 0.0 2.3 2 0 0 2 2 2 0 Integrase core domain gag-asp_proteas PF13975.1 KII73059.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Myb_DNA-bind_5 PF13873.1 KII73059.1 - 1.6 8.7 6.7 2.4 8.0 0.3 3.6 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.20 KII73060.1 - 1.7e-62 210.8 0.2 2.2e-62 210.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII73060.1 - 1e-35 123.0 0.1 1.3e-35 122.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII73060.1 - 5.6e-07 28.7 0.0 8e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KII73060.1 - 0.013 14.3 0.0 0.022 13.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.9 KII73060.1 - 0.015 14.3 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1012 PF06241.7 KII73060.1 - 0.015 14.8 0.3 0.062 12.8 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1012) RIO1 PF01163.17 KII73060.1 - 0.026 13.8 0.3 0.069 12.4 0.0 1.7 2 0 0 2 2 2 0 RIO1 family APH PF01636.18 KII73060.1 - 0.055 13.1 0.0 0.1 12.2 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF3895 PF13034.1 KII73060.1 - 0.11 11.9 0.3 0.42 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3895) TPR_11 PF13414.1 KII73062.1 - 4e-21 74.4 6.2 2e-15 56.1 0.6 3.0 2 2 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 KII73062.1 - 6.4e-11 41.3 4.1 2e-05 23.9 0.1 4.0 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 KII73062.1 - 1.5e-10 40.4 0.5 0.00088 19.2 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KII73062.1 - 4.5e-10 38.6 5.4 2.2e-05 24.0 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 KII73062.1 - 1.6e-05 24.6 0.1 0.00071 19.3 0.1 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KII73062.1 - 0.00015 22.3 1.3 0.026 15.2 0.2 2.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KII73062.1 - 0.0003 21.1 0.0 3.9 8.3 0.0 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat CotJB PF12652.2 KII73062.1 - 0.00037 20.5 0.1 0.0011 18.9 0.0 1.8 2 0 0 2 2 2 1 CotJB protein TPR_8 PF13181.1 KII73062.1 - 0.00054 19.5 5.2 0.014 15.1 0.2 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 KII73062.1 - 0.00091 19.5 0.2 0.013 15.8 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 KII73062.1 - 0.0035 17.7 1.1 0.16 12.4 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 KII73062.1 - 0.016 15.0 3.4 0.039 13.8 0.3 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat NYD-SP12_N PF15015.1 KII73062.1 - 0.11 10.6 0.1 0.13 10.4 0.0 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal Cypo_polyhedrin PF05865.6 KII73063.1 - 0.021 14.0 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 Cypovirus polyhedrin protein KH_1 PF00013.24 KII73064.1 - 0.1 12.2 6.1 24 4.6 0.0 4.8 5 0 0 5 5 5 0 KH domain MBF1 PF08523.5 KII73065.1 - 0.042 13.8 0.1 0.061 13.3 0.1 1.2 1 0 0 1 1 1 0 Multiprotein bridging factor 1 BssC_TutF PF08201.6 KII73068.1 - 6.3 6.3 8.0 47 3.5 0.1 3.7 4 0 0 4 4 4 0 BssC/TutF protein Dynamin_N PF00350.18 KII73071.1 - 4.5e-19 68.8 1.7 5.9e-13 48.9 0.1 2.4 2 1 1 3 3 3 2 Dynamin family MMR_HSR1 PF01926.18 KII73071.1 - 2.2e-08 34.0 0.2 6.9e-08 32.4 0.2 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 KII73071.1 - 0.0013 17.9 0.1 0.0018 17.4 0.1 1.3 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 KII73071.1 - 0.0022 18.4 0.1 0.0046 17.4 0.0 1.7 1 1 0 1 1 1 1 Miro-like protein Septin PF00735.13 KII73071.1 - 0.0037 16.3 0.0 0.012 14.6 0.0 1.7 1 1 1 2 2 2 1 Septin PduV-EutP PF10662.4 KII73071.1 - 0.0038 16.7 0.3 0.058 12.8 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 KII73071.1 - 0.0083 16.1 0.0 0.011 15.7 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain Dynamin_M PF01031.15 KII73071.1 - 0.012 14.3 0.1 0.019 13.7 0.1 1.3 1 0 0 1 1 1 0 Dynamin central region AAA_29 PF13555.1 KII73071.1 - 0.08 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 KII73071.1 - 0.099 11.8 0.1 0.13 11.4 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 KII73071.1 - 0.11 11.9 0.5 9.4 5.6 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Ras PF00071.17 KII73071.1 - 0.22 10.9 1.4 1.6 8.1 0.0 2.3 2 1 0 2 2 2 0 Ras family Dpy-30 PF05186.8 KII73072.1 - 6.4e-09 35.1 0.1 1.2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Dpy-30 motif Radial_spoke PF04712.7 KII73072.1 - 0.062 12.0 0.0 0.066 11.9 0.0 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein SMK-1 PF04802.10 KII73073.1 - 8.7e-44 149.3 3.0 8.7e-44 149.3 2.1 2.1 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 UCH PF00443.24 KII73074.1 - 5.4e-41 140.4 1.1 5.4e-41 140.4 0.8 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KII73074.1 - 1.7e-22 80.2 1.3 6.2e-22 78.3 0.9 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ipi1_N PF12333.3 KII73074.1 - 0.07 13.1 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation DDE_3 PF13358.1 KII73075.1 - 5.8e-07 29.3 0.0 7e-07 29.0 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII73075.1 - 0.042 12.9 0.3 0.055 12.5 0.2 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF464 PF04327.7 KII73075.1 - 0.083 13.1 0.4 0.11 12.7 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF464) DUF3975 PF13126.1 KII73075.1 - 0.099 12.8 0.3 0.16 12.1 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3975) SLAM PF06214.6 KII73075.1 - 1.4 8.8 4.3 7.4 6.5 0.9 2.2 1 1 1 2 2 2 0 Signaling lymphocytic activation molecule (SLAM) protein EF-hand_7 PF13499.1 KII73077.1 - 2e-11 43.8 5.9 5.1e-11 42.5 2.9 1.9 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KII73077.1 - 9.2e-07 27.7 5.5 0.00065 18.8 0.1 3.0 3 1 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KII73077.1 - 2e-06 27.1 1.1 0.022 14.6 0.2 2.7 1 1 1 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KII73077.1 - 1.5e-05 24.4 5.1 0.00016 21.2 1.4 2.8 1 1 1 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KII73077.1 - 0.032 14.2 1.2 0.11 12.5 0.9 1.9 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region BEX PF04538.7 KII73077.1 - 0.037 14.2 0.8 0.051 13.7 0.5 1.3 1 1 0 1 1 1 0 Brain expressed X-linked like family Nefa_Nip30_N PF10187.4 KII73077.1 - 0.042 14.0 1.6 0.06 13.5 1.1 1.4 1 0 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 RST PF12174.3 KII73077.1 - 0.051 13.3 0.4 0.15 11.8 0.1 1.9 1 1 1 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Pathogen_betaC1 PF09593.5 KII73077.1 - 0.058 13.1 1.0 0.092 12.4 0.3 1.6 1 1 0 2 2 2 0 Beta-satellite pathogenicity beta C1 protein SSrecog PF03531.9 KII73077.1 - 0.059 12.6 0.4 0.067 12.5 0.3 1.1 1 0 0 1 1 1 0 Structure-specific recognition protein (SSRP1) EF-hand_5 PF13202.1 KII73077.1 - 0.15 11.4 1.4 0.5 9.8 0.1 2.4 2 1 0 2 2 2 0 EF hand DUF3461 PF11944.3 KII73077.1 - 0.54 10.1 4.6 9.4 6.0 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3461) Topoisom_I PF01028.15 KII73078.1 - 8.7e-37 126.4 3.5 8.7e-37 126.4 2.5 1.8 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 KII73078.1 - 1.4e-31 107.9 0.1 1.4e-31 107.9 0.1 2.1 2 0 0 2 2 1 1 C-terminal topoisomerase domain DUF342 PF03961.8 KII73078.1 - 0.00056 18.4 8.0 0.00056 18.4 5.5 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF342) RTBV_P46 PF06216.6 KII73078.1 - 0.0022 16.9 2.2 0.0032 16.3 1.5 1.2 1 0 0 1 1 1 1 Rice tungro bacilliform virus P46 protein Lebercilin PF15619.1 KII73078.1 - 0.0024 17.3 13.7 0.0054 16.1 9.5 1.4 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DUF2458 PF10454.4 KII73078.1 - 0.0027 17.5 9.2 0.052 13.4 6.4 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF2458) DUF2935 PF11155.3 KII73078.1 - 0.0081 16.2 5.3 0.0081 16.2 3.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF2935) DUF869 PF05911.6 KII73078.1 - 0.011 14.0 8.3 0.013 13.7 5.8 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Exonuc_VII_L PF02601.10 KII73078.1 - 0.013 14.7 8.1 0.018 14.2 5.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2353 PF09789.4 KII73078.1 - 0.015 14.5 8.2 0.023 13.9 5.7 1.3 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Val_tRNA-synt_C PF10458.4 KII73078.1 - 0.018 15.0 4.9 0.97 9.5 0.1 2.6 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm TBPIP PF07106.8 KII73078.1 - 0.022 14.3 15.5 1 8.8 8.2 2.4 1 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TyeA PF09059.5 KII73078.1 - 0.044 13.7 0.6 0.15 12.0 0.1 2.0 2 1 0 2 2 1 0 TyeA AAA_23 PF13476.1 KII73078.1 - 0.066 13.5 8.7 0.091 13.0 6.0 1.4 1 0 0 1 1 1 0 AAA domain BRE1 PF08647.6 KII73078.1 - 0.092 12.7 14.1 0.32 10.9 1.7 3.1 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Fib_alpha PF08702.5 KII73078.1 - 0.11 12.6 13.2 0.17 12.0 9.1 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Rab5-bind PF09311.6 KII73078.1 - 0.12 12.2 5.5 0.27 11.0 1.0 2.2 1 1 1 2 2 2 0 Rabaptin-like protein AATF-Che1 PF13339.1 KII73078.1 - 0.2 11.7 10.8 0.14 12.3 1.8 2.2 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor NAAA-beta PF15508.1 KII73078.1 - 0.22 11.8 1.4 8.1 6.8 0.3 2.6 1 1 2 3 3 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Vmethyltransf_C PF08456.5 KII73078.1 - 0.24 10.7 5.2 3.4 7.0 2.0 2.1 1 1 1 2 2 2 0 Viral methyltransferase C-terminal ADIP PF11559.3 KII73078.1 - 0.25 11.2 14.8 0.4 10.5 6.7 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Orbi_VP5 PF00901.12 KII73078.1 - 0.26 9.4 6.0 0.32 9.1 4.2 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 PMC2NT PF08066.7 KII73078.1 - 0.3 11.4 2.8 0.49 10.7 0.9 2.1 1 1 1 2 2 2 0 PMC2NT (NUC016) domain DUF3166 PF11365.3 KII73078.1 - 0.39 11.2 4.3 2 8.9 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) Atg14 PF10186.4 KII73078.1 - 0.41 9.5 11.9 0.97 8.3 8.3 1.7 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Prefoldin PF02996.12 KII73078.1 - 0.57 9.8 12.0 4.2 7.0 0.4 3.1 3 0 0 3 3 3 0 Prefoldin subunit IncA PF04156.9 KII73078.1 - 0.76 9.3 10.4 4.2 6.9 7.2 1.9 1 1 0 1 1 1 0 IncA protein FlxA PF14282.1 KII73078.1 - 0.78 9.7 16.9 0.6 10.0 3.3 3.2 1 1 2 3 3 3 0 FlxA-like protein Tup_N PF08581.5 KII73078.1 - 0.8 9.9 6.7 2.6 8.3 3.2 2.7 1 1 1 2 2 2 0 Tup N-terminal PNK3P PF08645.6 KII73078.1 - 0.85 9.0 4.9 0.65 9.4 0.8 2.0 1 1 1 2 2 2 0 Polynucleotide kinase 3 phosphatase DUF1664 PF07889.7 KII73078.1 - 0.91 9.3 6.9 1.3 8.8 2.9 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF641 PF04859.7 KII73078.1 - 0.97 9.1 10.2 0.49 10.1 2.8 2.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Mnd1 PF03962.10 KII73078.1 - 1.1 8.9 12.5 9.4 5.8 8.9 2.0 1 1 1 2 2 2 0 Mnd1 family Allexi_40kDa PF05549.6 KII73078.1 - 1.1 8.4 7.5 2.2 7.4 5.2 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein Occludin_ELL PF07303.8 KII73078.1 - 1.1 10.0 12.0 1.4 9.6 2.2 2.4 1 1 2 3 3 3 0 Occludin homology domain Med10 PF09748.4 KII73078.1 - 1.4 8.7 7.1 23 4.8 2.8 2.9 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex FlaC_arch PF05377.6 KII73078.1 - 1.5 8.7 10.9 7.7 6.4 1.8 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Kinetocho_Slk19 PF12709.2 KII73078.1 - 2 8.5 13.9 2.7 8.1 0.8 3.0 2 1 1 3 3 3 0 Central kinetochore-associated DUF904 PF06005.7 KII73078.1 - 2 8.7 14.8 19 5.6 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Med9 PF07544.8 KII73078.1 - 2.2 8.0 11.2 12 5.7 2.0 2.7 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 OmpH PF03938.9 KII73078.1 - 3 7.7 11.9 18 5.2 8.2 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Baculo_PEP_C PF04513.7 KII73078.1 - 5.1 6.9 7.0 10 5.9 2.2 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Myb_DNA-bind_4 PF13837.1 KII73078.1 - 5.5 7.1 8.6 77 3.5 0.5 2.4 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF972 PF06156.8 KII73078.1 - 5.8 7.3 14.3 8.3 6.8 6.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) SlyX PF04102.7 KII73078.1 - 6.6 7.1 8.3 15 6.0 0.3 3.4 3 1 1 4 4 3 0 SlyX Fzo_mitofusin PF04799.8 KII73078.1 - 7 5.9 8.4 3.2 7.0 3.8 1.8 1 1 1 2 2 2 0 fzo-like conserved region ATG16 PF08614.6 KII73078.1 - 7.5 6.3 15.1 2.4 7.9 3.1 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Prefoldin_2 PF01920.15 KII73078.1 - 9.7 6.0 17.1 2 8.1 1.7 3.1 1 1 2 3 3 3 0 Prefoldin subunit Topoisom_I_N PF02919.10 KII73079.1 - 7.5e-100 332.6 3.0 7.5e-100 332.6 2.1 1.6 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 KII73079.1 - 2.4e-40 138.1 0.3 4.4e-40 137.2 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Lactamase_B_2 PF12706.2 KII73080.1 - 4.2e-14 52.5 1.8 4.5e-06 26.3 0.5 2.6 2 1 1 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.22 KII73080.1 - 3.1e-08 33.5 0.4 3.5e-06 26.8 0.1 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily 7tm_1 PF00001.16 KII73081.1 - 1.5e-16 60.2 13.8 1.5e-16 60.2 9.6 1.7 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) UPF0233 PF06781.7 KII73081.1 - 0.39 10.3 4.2 0.4 10.3 0.4 2.7 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0233) DUF3040 PF11239.3 KII73081.1 - 6.2 6.9 5.9 6.6 6.8 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) NigD PF12667.2 KII73082.1 - 0.013 15.2 1.1 0.014 15.1 0.8 1.2 1 0 0 1 1 1 0 NigD-like protein Nodulin PF02451.10 KII73083.1 - 0.013 14.9 0.1 0.023 14.1 0.1 1.4 1 0 0 1 1 1 0 Nodulin Ribosomal_S7e PF01251.13 KII73084.1 - 3e-38 131.1 1.8 3.7e-38 130.9 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S7e DUF3393 PF11873.3 KII73085.1 - 0.1 12.1 0.1 0.16 11.4 0.0 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3393) PCNA_C PF02747.10 KII73086.1 - 0.11 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain UAA PF08449.6 KII73087.1 - 8.1e-07 28.2 1.5 8.3e-07 28.2 1.0 1.1 1 0 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KII73087.1 - 0.0041 17.3 1.1 0.0053 16.9 0.3 1.5 2 0 0 2 2 2 1 Multidrug resistance efflux transporter EamA PF00892.15 KII73087.1 - 0.12 12.4 6.6 0.027 14.4 2.4 1.6 2 0 0 2 2 2 0 EamA-like transporter family MULE PF10551.4 KII73090.1 - 0.0019 18.2 0.3 0.004 17.3 0.2 1.5 1 1 1 2 2 2 1 MULE transposase domain PLAC8 PF04749.12 KII73093.1 - 8.4e-18 64.8 18.0 9.7e-18 64.6 12.5 1.1 1 0 0 1 1 1 1 PLAC8 family DDE_3 PF13358.1 KII73094.1 - 0.013 15.2 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease MAPKK1_Int PF08923.5 KII73094.1 - 0.038 13.6 0.1 3.5 7.2 0.0 2.2 2 0 0 2 2 2 0 Mitogen-activated protein kinase kinase 1 interacting Myb_DNA-binding PF00249.26 KII73095.1 - 1.3e-21 76.3 7.1 2.1e-11 43.6 1.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KII73095.1 - 2.2e-21 75.7 6.5 1.1e-13 51.0 2.0 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_Cef PF11831.3 KII73095.1 - 0.001 18.3 0.1 0.001 18.3 0.1 3.2 3 0 0 3 3 3 2 pre-mRNA splicing factor component DEAD PF00270.24 KII73096.1 - 7e-37 126.5 0.2 2.7e-36 124.5 0.2 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII73096.1 - 1.8e-21 75.7 0.0 4e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII73096.1 - 6e-06 26.1 0.0 6e-06 26.1 0.0 3.2 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KII73096.1 - 0.00021 20.2 0.1 0.012 14.3 0.0 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.1 KII73096.1 - 0.002 18.2 0.0 0.0064 16.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain SecA_DEAD PF07517.9 KII73096.1 - 0.0047 16.2 0.8 0.013 14.7 0.0 2.1 3 0 0 3 3 3 1 SecA DEAD-like domain Ig_3 PF13927.1 KII73097.1 - 6.8e-06 26.4 0.9 0.0008 19.8 0.0 2.8 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.1 KII73097.1 - 1.7e-05 24.8 0.1 0.0019 18.2 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.11 KII73097.1 - 6.2e-05 22.7 0.0 0.013 15.3 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.20 KII73097.1 - 0.0026 17.8 1.3 0.45 10.6 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.12 KII73097.1 - 0.029 14.2 0.8 0.83 9.5 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin V-set domain Pkinase PF00069.20 KII73101.1 - 2.1e-68 230.3 0.2 3e-68 229.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII73101.1 - 9.5e-40 136.2 0.0 1.4e-39 135.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KII73101.1 - 2e-06 27.0 0.0 1.2e-05 24.4 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 KII73101.1 - 0.0073 15.3 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family CutA1 PF03091.10 KII73103.1 - 0.0058 16.2 0.7 0.062 12.9 0.0 2.1 1 1 1 2 2 2 1 CutA1 divalent ion tolerance protein UPF0167 PF03691.9 KII73103.1 - 0.0075 15.6 0.0 0.0095 15.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0167) DUF4295 PF14128.1 KII73103.1 - 0.039 13.5 0.1 0.08 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4295) LytR_cpsA_psr PF03816.9 KII73104.1 - 0.068 13.0 0.0 0.083 12.7 0.0 1.1 1 0 0 1 1 1 0 Cell envelope-related transcriptional attenuator domain PGAP1 PF07819.8 KII73104.1 - 0.11 12.1 0.1 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 PGAP1-like protein Serpin PF00079.15 KII73105.1 - 2.4e-69 234.2 4.0 2.7e-69 234.0 2.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Herpes_UL73 PF03554.8 KII73106.1 - 3.8 7.4 9.0 11 5.9 0.1 3.2 3 0 0 3 3 3 0 UL73 viral envelope glycoprotein Phage_Gp111 PF07410.6 KII73107.1 - 0.018 15.2 1.1 0.026 14.6 0.8 1.2 1 0 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein PSCyt2 PF07583.6 KII73109.1 - 0.048 13.1 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1549) Retrotrans_gag PF03732.12 KII73110.1 - 0.00095 19.1 0.2 0.0022 18.0 0.1 1.7 1 1 0 1 1 1 1 Retrotransposon gag protein DOPA_dioxygen PF08883.6 KII73110.1 - 0.04 13.9 0.1 0.88 9.6 0.0 2.4 2 0 0 2 2 2 0 Dopa 4,5-dioxygenase family DUF4219 PF13961.1 KII73110.1 - 0.063 12.7 0.2 5.8 6.4 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) UBN2_2 PF14227.1 KII73110.1 - 0.075 12.5 2.1 0.28 10.7 0.2 2.3 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type RVT_1 PF00078.22 KII73111.1 - 2.5e-15 56.4 0.1 1e-14 54.4 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII73111.1 - 1.6e-07 31.1 0.2 3.6e-07 30.0 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII73111.1 - 2.2e-06 28.0 0.0 5.2e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII73111.1 - 6.2e-06 25.9 0.0 1.5e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII73111.1 - 0.0025 17.7 0.0 0.0054 16.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII73111.1 - 0.016 14.7 0.0 0.043 13.3 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.1 KII73111.1 - 0.049 13.1 3.9 0.13 11.7 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger F-box PF00646.28 KII73114.1 - 0.0083 15.7 0.5 0.061 12.9 0.0 2.5 2 0 0 2 2 2 1 F-box domain LRR_7 PF13504.1 KII73114.1 - 0.12 12.7 0.1 23 5.7 0.0 3.4 3 0 0 3 3 3 0 Leucine rich repeat LRR_1 PF00560.28 KII73114.1 - 0.4 10.8 7.0 24 5.4 0.3 4.3 4 1 0 4 4 4 0 Leucine Rich Repeat SNAP PF14938.1 KII73115.1 - 1.3e-08 34.2 0.5 1.8e-08 33.8 0.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF2365 PF10157.4 KII73115.1 - 0.0007 19.5 0.1 0.00094 19.0 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2365) Enkurin PF13864.1 KII73115.1 - 0.042 14.0 1.2 0.22 11.7 0.2 2.2 2 0 0 2 2 2 0 Calmodulin-binding Arb2 PF09757.4 KII73115.1 - 0.11 11.9 0.4 6.6 6.1 0.1 2.2 2 0 0 2 2 2 0 Arb2 domain ShK PF01549.19 KII73119.1 - 0.06 13.7 1.2 0.19 12.0 0.1 2.2 2 0 0 2 2 2 0 ShK domain-like RVT_1 PF00078.22 KII73120.1 - 1.9e-15 56.8 0.1 8.3e-15 54.7 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII73120.1 - 1.3e-07 31.4 0.2 3e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII73120.1 - 1.7e-06 28.3 0.0 4.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII73120.1 - 5e-06 26.2 0.0 1.3e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII73120.1 - 0.0021 18.0 0.0 0.0044 16.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII73120.1 - 0.013 15.0 0.0 0.036 13.6 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.1 KII73120.1 - 0.04 13.4 3.9 0.11 11.9 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.18 KII73120.1 - 1.5 8.8 4.8 10 6.2 0.2 2.7 2 0 0 2 2 2 0 Zinc knuckle DUF211 PF02680.9 KII73123.1 - 0.071 12.9 8.8 0.19 11.5 2.8 2.7 1 1 2 3 3 3 0 Uncharacterized ArCR, COG1888 Herpes_gE PF02480.11 KII73124.1 - 0.0024 16.2 0.0 0.0028 15.9 0.0 1.0 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E CcmH PF03918.9 KII73124.1 - 0.043 12.8 0.0 0.062 12.2 0.0 1.3 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Glycophorin_A PF01102.13 KII73124.1 - 0.073 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A Exonuc_VIII PF06630.6 KII73126.1 - 0.11 11.8 0.5 0.12 11.7 0.3 1.1 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII Mucin PF01456.12 KII73126.1 - 0.15 11.8 5.9 0.19 11.4 4.1 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Amidohydro_2 PF04909.9 KII73128.1 - 1.4e-40 139.6 0.1 1.7e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 KII73128.1 - 0.0067 15.6 0.0 0.0083 15.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family LysR_substrate PF03466.15 KII73129.1 - 5.2e-11 42.0 0.3 6.4e-11 41.7 0.2 1.0 1 0 0 1 1 1 1 LysR substrate binding domain Ldl_recept_a PF00057.13 KII73130.1 - 0.0046 16.8 3.0 0.0078 16.0 2.1 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF3754 PF12576.3 KII73130.1 - 0.074 12.6 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) TFIIE_beta PF02186.10 KII73130.1 - 0.077 13.0 0.1 0.78 9.7 0.0 2.3 2 1 0 2 2 2 0 TFIIE beta subunit core domain RVT_1 PF00078.22 KII73132.1 - 0.0012 18.2 0.5 0.0022 17.3 0.3 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_connect PF06815.8 KII73132.1 - 0.09 12.6 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase connection domain Ldl_recept_a PF00057.13 KII73135.1 - 1.2e-28 98.6 70.2 1.2e-10 41.1 11.5 4.4 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A Glycos_transf_2 PF00535.21 KII73136.1 - 5.8e-27 94.4 0.0 1.1e-26 93.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 KII73136.1 - 8e-18 64.4 0.6 2.5e-08 33.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.1 KII73136.1 - 1.3e-14 54.6 0.0 2.5e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_1 PF00534.15 KII73136.1 - 5.6e-12 45.4 0.3 1.3e-09 37.7 0.1 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_7C PF02709.9 KII73136.1 - 3.6e-06 26.3 0.1 8.4e-06 25.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_trans_4_4 PF13579.1 KII73136.1 - 8.7e-06 25.9 0.0 2.6e-05 24.4 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 KII73136.1 - 0.00016 21.8 0.0 0.0015 18.7 0.0 2.3 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.6 KII73136.1 - 0.00094 18.7 0.2 0.057 12.8 0.1 2.6 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_transf_21 PF13506.1 KII73136.1 - 0.0017 17.6 0.0 0.0045 16.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.1 KII73136.1 - 0.0062 16.2 0.0 0.022 14.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_4 PF13439.1 KII73136.1 - 0.085 12.5 0.0 0.89 9.2 0.0 2.4 1 1 0 1 1 1 0 Glycosyltransferase Family 4 PS_pyruv_trans PF04230.8 KII73137.1 - 1.1e-12 48.3 0.4 3.4e-12 46.6 0.3 1.7 1 1 0 1 1 1 1 Polysaccharide pyruvyl transferase DUF1284 PF06935.6 KII73137.1 - 0.0096 16.0 0.0 1.7 8.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1284) CW_binding_2 PF04122.7 KII73138.1 - 0.019 15.1 0.3 0.024 14.8 0.2 1.2 1 0 0 1 1 1 0 Putative cell wall binding repeat 2 DUF3909 PF13077.1 KII73138.1 - 0.023 14.5 0.1 0.039 13.8 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3909) Sugar_tr PF00083.19 KII73139.1 - 9.7e-42 143.0 5.9 1.1e-41 142.8 4.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KII73139.1 - 9.3e-20 70.6 12.3 1.3e-19 70.2 8.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily PrgI PF12666.2 KII73139.1 - 4.6 7.4 8.2 0.85 9.7 0.1 2.6 2 1 1 3 3 3 0 PrgI family protein GidB PF02527.10 KII73140.1 - 0.037 13.1 0.2 0.041 13.0 0.1 1.1 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G ARPC4 PF05856.7 KII73140.1 - 0.059 12.7 0.7 0.19 11.1 0.1 1.9 2 0 0 2 2 2 0 ARP2/3 complex 20 kDa subunit (ARPC4) Orn_Arg_deC_N PF02784.11 KII73141.1 - 1e-34 119.8 0.0 5.6e-33 114.1 0.0 1.9 1 1 1 2 2 2 2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 KII73141.1 - 9.8e-07 28.4 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Phage_fiber PF03335.8 KII73142.1 - 0.086 12.5 0.7 1.1 9.1 0.0 2.7 3 0 0 3 3 3 0 Phage tail fibre repeat Mor PF08765.6 KII73143.1 - 0.0075 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Mor transcription activator family OSCP PF00213.13 KII73143.1 - 0.05 13.4 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit R3H PF01424.17 KII73144.1 - 0.00012 21.7 0.9 0.0018 17.9 0.1 3.1 4 0 0 4 4 4 1 R3H domain DUF4158 PF13700.1 KII73144.1 - 0.0026 17.2 0.3 0.0074 15.7 0.2 1.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4158) DUF1311 PF07007.7 KII73145.1 - 0.021 14.9 0.1 0.027 14.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1311) Smr PF01713.16 KII73147.1 - 1.7e-06 28.1 0.0 2.9e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Smr domain DUF2088 PF09861.4 KII73147.1 - 0.062 12.3 0.0 0.094 11.7 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF2088) PPTA PF01239.17 KII73150.1 - 0.11 11.9 0.4 0.24 10.8 0.3 1.6 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat Dpy19 PF10034.4 KII73155.1 - 0.047 11.8 0.0 0.049 11.8 0.0 1.0 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF202 PF02656.10 KII73155.1 - 1.8 8.8 4.4 3.1 8.0 3.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF202) PMP22_Claudin PF00822.15 KII73156.1 - 0.0013 18.4 0.6 0.0021 17.7 0.4 1.5 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF4064 PF13273.1 KII73156.1 - 0.11 12.6 2.9 0.085 12.9 0.9 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF1772 PF08592.6 KII73156.1 - 0.78 9.4 3.9 0.48 10.1 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF2627 PF11118.3 KII73156.1 - 1.5 8.9 5.3 4.6 7.4 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) Chordopox_A13L PF05961.6 KII73156.1 - 1.5 8.7 5.8 0.64 9.9 1.2 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Claudin_2 PF13903.1 KII73156.1 - 1.8 8.2 7.2 0.32 10.6 2.2 1.8 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Baculo_11_kDa PF06143.6 KII73156.1 - 8.7 5.7 9.5 0.27 10.6 1.0 2.3 1 1 1 2 2 2 0 Baculovirus 11 kDa family NfeD PF01957.13 KII73156.1 - 9.5 6.3 10.2 7.1 6.7 3.8 2.4 2 1 1 3 3 3 0 NfeD-like C-terminal, partner-binding PMP22_Claudin PF00822.15 KII73158.1 - 0.0013 18.4 0.6 0.0021 17.7 0.4 1.5 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF4064 PF13273.1 KII73158.1 - 0.11 12.6 2.9 0.085 12.9 0.9 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF1772 PF08592.6 KII73158.1 - 0.78 9.4 3.9 0.48 10.1 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF2627 PF11118.3 KII73158.1 - 1.5 8.9 5.3 4.6 7.4 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) Chordopox_A13L PF05961.6 KII73158.1 - 1.5 8.7 5.8 0.64 9.9 1.2 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Claudin_2 PF13903.1 KII73158.1 - 1.8 8.2 7.2 0.32 10.6 2.2 1.8 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Baculo_11_kDa PF06143.6 KII73158.1 - 8.7 5.7 9.5 0.27 10.6 1.0 2.3 1 1 1 2 2 2 0 Baculovirus 11 kDa family NfeD PF01957.13 KII73158.1 - 9.5 6.3 10.2 7.1 6.7 3.8 2.4 2 1 1 3 3 3 0 NfeD-like C-terminal, partner-binding RelA_SpoT PF04607.12 KII73159.1 - 0.38 10.7 3.8 0.74 9.8 0.6 2.2 2 1 0 2 2 2 0 Region found in RelA / SpoT proteins Glycos_transf_2 PF00535.21 KII73160.1 - 3.5e-05 23.5 0.2 7.3e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 KII73160.1 - 0.0086 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 KII73160.1 - 0.015 15.1 0.0 0.038 13.7 0.0 1.7 1 1 0 1 1 1 0 Glycosyltransferase like family 2 PHB_acc_N PF07879.6 KII73161.1 - 0.0014 18.2 0.2 0.0031 17.2 0.1 1.5 1 0 0 1 1 1 1 PHB/PHA accumulation regulator DNA-binding domain DDE_3 PF13358.1 KII73163.1 - 1.9e-13 50.3 0.2 2.3e-13 50.1 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Flu_C_NS1 PF03506.8 KII73164.1 - 0.084 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) DUF3278 PF11683.3 KII73167.1 - 1 9.3 6.2 1.4 8.9 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3278) DUF3671 PF12420.3 KII73167.1 - 4.8 7.1 14.6 3.1e+02 1.4 10.1 2.5 1 1 0 1 1 1 0 Protein of unknown function Toxin_56 PF15534.1 KII73168.1 - 0.15 12.5 0.5 0.27 11.7 0.1 1.6 2 0 0 2 2 2 0 Putative toxin 56 TFIID_20kDa PF03847.8 KII73169.1 - 2.3e-14 53.4 1.0 2.9e-14 53.0 0.7 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CTP_transf_1 PF01148.15 KII73170.1 - 4e-54 184.0 27.9 6.1e-54 183.3 19.4 1.3 1 0 0 1 1 1 1 Cytidylyltransferase family COX4_pro_2 PF07835.7 KII73170.1 - 6.7 6.7 16.4 1.6 8.7 2.4 3.6 3 0 0 3 3 3 0 Bacterial aa3 type cytochrome c oxidase subunit IV AAA_23 PF13476.1 KII73172.1 - 0.029 14.6 1.9 0.03 14.6 1.3 1.1 1 0 0 1 1 1 0 AAA domain Cluap1 PF10234.4 KII73172.1 - 0.068 12.3 6.0 0.082 12.1 4.1 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 Nucleocap_ssRNA PF11128.3 KII73172.1 - 0.18 11.2 3.4 0.7 9.3 2.4 1.8 1 1 0 1 1 1 0 Plant viral coat protein nucleocapsid WD40 PF00400.27 KII73173.1 - 3.5e-12 45.6 1.7 0.0019 18.0 0.1 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat SSP160 PF06933.6 KII73174.1 - 0.03 12.3 0.1 0.042 11.8 0.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 fn3 PF00041.16 KII73174.1 - 0.13 12.4 0.0 7.7 6.7 0.0 3.1 3 0 0 3 3 3 0 Fibronectin type III domain zf-C3HC PF07967.8 KII73175.1 - 1.2e-16 60.7 0.1 1.4e-16 60.4 0.1 1.1 1 0 0 1 1 1 1 C3HC zinc finger-like BIR PF00653.16 KII73175.1 - 0.092 13.1 0.6 0.19 12.1 0.4 1.6 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain MT-A70 PF05063.9 KII73176.1 - 1.2e-12 47.7 0.0 5.3e-10 39.1 0.0 2.4 2 1 0 2 2 2 2 MT-A70 TPR_8 PF13181.1 KII73178.1 - 0.0093 15.6 0.1 5.7 6.9 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 KII73178.1 - 0.042 13.9 1.0 0.25 11.5 0.3 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 IKI3 PF04762.7 KII73179.1 - 8.8e-35 119.8 2.6 1.1e-34 119.5 1.8 1.0 1 0 0 1 1 1 1 IKI3 family IKI3 PF04762.7 KII73180.1 - 1.6e-42 145.4 0.0 1.7e-42 145.3 0.0 1.0 1 0 0 1 1 1 1 IKI3 family WD40 PF00400.27 KII73181.1 - 1.8e-06 27.6 3.3 0.0013 18.5 0.0 4.4 5 1 0 5 5 5 2 WD domain, G-beta repeat Ribosomal_L22 PF00237.14 KII73182.1 - 1.4e-06 28.1 0.1 2.4e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e ACPS PF01648.15 KII73183.1 - 4.8e-06 26.3 0.0 3.1e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Sel1 PF08238.7 KII73184.1 - 1.1e-07 32.2 5.2 0.39 11.4 0.0 5.2 5 0 0 5 5 5 3 Sel1 repeat DUF4635 PF15466.1 KII73185.1 - 0.01 15.1 1.1 2.6 7.3 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4635) DUF4197 PF13852.1 KII73186.1 - 0.053 13.0 0.1 0.12 11.9 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4197) Phage_head_fibr PF11133.3 KII73186.1 - 0.076 12.2 0.0 0.11 11.7 0.0 1.3 1 1 0 1 1 1 0 Head fiber protein ORF6C PF10552.4 KII73187.1 - 0.016 14.8 0.8 0.023 14.4 0.5 1.2 1 0 0 1 1 1 0 ORF6C domain YjcZ PF13990.1 KII73187.1 - 0.073 12.1 0.1 0.079 12.0 0.1 1.1 1 0 0 1 1 1 0 YjcZ-like protein VitD-bind_III PF09164.5 KII73187.1 - 0.2 11.2 1.6 0.24 11.0 0.1 1.8 2 0 0 2 2 2 0 Vitamin D binding protein, domain III UPF0122 PF04297.9 KII73187.1 - 0.92 9.5 7.2 1.1 9.3 0.2 2.6 1 1 2 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like zf-MIZ PF02891.15 KII73188.1 - 6.1e-12 44.8 3.6 1.1e-11 43.9 2.5 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 KII73188.1 - 0.0021 17.5 2.5 0.0053 16.2 1.8 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DDE_Tnp_IS1595 PF12762.2 KII73189.1 - 1.1e-08 35.0 0.0 1.6e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain WEMBL PF05701.6 KII73191.1 - 0.00058 18.4 1.9 0.00058 18.4 1.3 2.0 1 1 1 2 2 2 1 Weak chloroplast movement under blue light Sec8_exocyst PF04048.9 KII73191.1 - 0.004 16.8 2.1 0.004 16.8 1.5 2.1 1 1 0 2 2 2 1 Sec8 exocyst complex component specific domain AAA_13 PF13166.1 KII73191.1 - 0.0065 14.9 10.5 0.0069 14.9 7.2 1.0 1 0 0 1 1 1 1 AAA domain IIGP PF05049.8 KII73191.1 - 0.036 12.8 3.9 0.037 12.8 2.3 1.3 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Spc7 PF08317.6 KII73191.1 - 0.042 12.4 12.5 0.057 12.0 8.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein SEA PF01390.15 KII73191.1 - 0.054 13.1 2.0 0.067 12.8 0.3 1.9 2 1 0 2 2 2 0 SEA domain APG6 PF04111.7 KII73191.1 - 0.072 12.1 10.5 0.087 11.8 7.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 CENP-F_leu_zip PF10473.4 KII73191.1 - 0.083 12.7 11.9 0.12 12.2 8.2 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Troponin PF00992.15 KII73191.1 - 0.21 11.6 9.5 0.38 10.8 6.0 1.7 1 1 1 2 2 2 0 Troponin MCPsignal PF00015.16 KII73191.1 - 0.36 10.3 3.5 0.43 10.1 1.9 1.4 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain BLOC1_2 PF10046.4 KII73191.1 - 0.95 9.6 12.2 1.4 9.0 2.9 2.4 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.6 KII73191.1 - 1.1 9.1 7.1 2.2 8.1 0.3 3.0 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Phage_GP20 PF06810.6 KII73191.1 - 3.5 7.0 11.5 0.41 10.0 2.8 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 Nsp1_C PF05064.8 KII73191.1 - 3.8 7.1 11.3 5.2 6.7 1.9 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region Mgr1 PF08602.5 KII73191.1 - 5.1 5.9 9.8 19 4.1 6.8 1.7 1 1 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit DDE_3 PF13358.1 KII73192.1 - 0.0029 17.3 0.0 0.0045 16.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 KII73193.1 - 1.8e-05 24.5 0.0 2.1e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease WD40 PF00400.27 KII73203.1 - 4.5e-26 89.7 8.9 3.4e-08 33.0 0.0 7.3 8 0 0 8 8 8 4 WD domain, G-beta repeat eIF2A PF08662.6 KII73203.1 - 0.0093 15.6 0.1 0.067 12.8 0.0 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A hNIFK_binding PF12196.3 KII73204.1 - 0.017 14.4 0.9 0.15 11.4 0.1 2.3 2 0 0 2 2 2 0 FHA Ki67 binding domain of hNIFK SMC_Nse1 PF07574.8 KII73204.1 - 0.21 11.2 1.1 3.1 7.3 0.0 2.0 2 0 0 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex EF-hand_7 PF13499.1 KII73205.1 - 9.8e-24 83.2 0.6 3.7e-11 42.9 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KII73205.1 - 7.2e-23 78.1 1.6 1.5e-05 23.9 0.4 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KII73205.1 - 2.7e-19 68.4 4.3 1.8e-08 33.8 0.0 3.9 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 KII73205.1 - 8.4e-19 65.7 2.1 1.5e-06 27.6 0.3 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KII73205.1 - 1.7e-09 36.5 4.3 0.0031 16.7 2.5 3.7 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.1 KII73205.1 - 2.3e-08 33.8 0.0 0.00057 19.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.8 KII73205.1 - 0.0022 17.5 0.0 2.4 7.8 0.0 2.5 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) Spo0A_C PF08769.6 KII73205.1 - 0.015 15.1 0.1 0.044 13.6 0.0 1.8 2 1 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal VanY PF02557.12 KII73205.1 - 0.044 13.6 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase DUF2267 PF10025.4 KII73205.1 - 0.078 13.0 0.0 0.45 10.5 0.0 2.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) HTH_45 PF14947.1 KII73208.1 - 0.00058 19.6 3.6 0.074 12.8 0.1 2.5 2 0 0 2 2 2 2 Winged helix-turn-helix DUF3116 PF11313.3 KII73208.1 - 0.074 12.6 1.2 0.25 10.9 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3116) z-alpha PF02295.12 KII73208.1 - 0.16 11.7 1.8 0.19 11.5 0.0 2.1 3 0 0 3 3 3 0 Adenosine deaminase z-alpha domain HTH_34 PF13601.1 KII73208.1 - 0.25 11.4 2.9 0.28 11.2 0.1 2.1 2 0 0 2 2 2 0 Winged helix DNA-binding domain Glycohydro_20b2 PF14845.1 KII73208.1 - 0.4 11.3 4.7 1 10.0 1.6 2.0 1 1 1 2 2 2 0 beta-acetyl hexosaminidase like tRNA-synt_2d PF01409.15 KII73209.1 - 2.2e-49 167.8 0.3 4.9e-49 166.7 0.2 1.5 1 1 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 KII73209.1 - 4.6e-06 25.6 0.1 1.1e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 KII73209.1 - 7e-05 22.4 0.1 0.00013 21.6 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) WD40 PF00400.27 KII73213.1 - 0.0012 18.6 0.4 0.0012 18.6 0.3 3.6 3 2 0 3 3 3 1 WD domain, G-beta repeat tRNA_lig_CPD PF08302.6 KII73214.1 - 0.054 12.6 0.7 0.079 12.1 0.0 1.6 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain DUF1722 PF08349.6 KII73214.1 - 0.056 13.3 0.1 0.097 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) PHO4 PF01384.15 KII73216.1 - 5.3e-81 271.7 10.6 4.7e-79 265.3 7.3 2.1 1 1 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.5 KII73216.1 - 0.0031 17.0 0.3 0.67 9.5 0.1 2.8 2 1 1 3 3 3 2 IclR helix-turn-helix domain Carb_anhydrase PF00194.16 KII73217.1 - 2.2e-42 144.7 0.2 1.9e-39 135.1 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.16 KII73218.1 - 9e-21 73.9 0.1 1e-20 73.7 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Glyco_hydro_65C PF03633.10 KII73218.1 - 0.038 14.0 0.5 5.2 7.2 0.0 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, C-terminal domain KH_4 PF13083.1 KII73218.1 - 0.19 11.3 0.8 0.4 10.3 0.1 1.8 2 0 0 2 2 2 0 KH domain Carb_anhydrase PF00194.16 KII73219.1 - 9.8e-23 80.4 0.7 1.1e-22 80.2 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Glyco_hydro_65C PF03633.10 KII73219.1 - 0.043 13.9 0.5 6.2 6.9 0.0 2.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, C-terminal domain Carb_anhydrase PF00194.16 KII73221.1 - 3.1e-34 118.1 0.3 3.6e-34 117.9 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase KH_4 PF13083.1 KII73221.1 - 0.11 12.1 0.0 0.29 10.8 0.0 1.7 1 0 0 1 1 1 0 KH domain TGF_beta_GS PF08515.7 KII73222.1 - 1.3 8.3 8.3 23 4.4 0.3 4.2 3 0 0 3 3 3 0 Transforming growth factor beta type I GS-motif Carb_anhydrase PF00194.16 KII73223.1 - 1.3e-45 155.4 0.0 1.8e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Pyr_redox_dim PF02852.17 KII73225.1 - 2.9e-36 123.8 0.0 3.7e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain CPG4 PF15481.1 KII73225.1 - 0.015 15.6 0.3 0.026 14.8 0.2 1.3 1 0 0 1 1 1 0 Chondroitin proteoglycan 4 Pyr_redox PF00070.22 KII73226.1 - 1.6e-11 44.4 0.0 2.4e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KII73226.1 - 6.4e-06 26.1 0.1 2.1e-05 24.5 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KII73226.1 - 0.0069 16.3 0.2 0.01 15.8 0.1 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.16 KII73226.1 - 0.033 13.7 0.1 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Ribosomal_L24e PF01246.15 KII73227.1 - 1.1e-30 105.2 1.1 1.1e-30 105.2 0.7 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e YhzD PF14120.1 KII73227.1 - 0.48 10.3 3.0 1.7 8.5 0.0 2.5 2 1 0 2 2 2 0 YhzD-like protein Band_3_cyto PF07565.8 KII73227.1 - 5.8 6.3 9.7 7.2 6.0 6.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2058 PF09831.4 KII73227.1 - 8.5 6.2 20.1 12 5.6 13.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) TPR_12 PF13424.1 KII73228.1 - 0.0012 18.7 0.9 0.18 11.7 0.1 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KII73228.1 - 0.031 14.4 0.4 0.26 11.5 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.4 KII73228.1 - 0.054 12.8 0.1 0.097 12.0 0.1 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Ifi-6-16 PF06140.8 KII73228.1 - 0.058 13.1 0.2 0.092 12.5 0.2 1.3 1 0 0 1 1 1 0 Interferon-induced 6-16 family ATP13 PF12921.2 KII73228.1 - 0.059 12.7 2.1 0.14 11.5 0.2 2.4 2 2 0 2 2 2 0 Mitochondrial ATPase expression TPR_2 PF07719.12 KII73228.1 - 0.097 12.6 0.3 5.4 7.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.9 KII73228.1 - 0.13 12.7 0.3 9.7 6.9 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 KII73228.1 - 0.14 12.1 0.1 2.2 8.3 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII73228.1 - 0.34 10.8 1.4 27 4.8 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ATP-synt_DE_N PF02823.11 KII73229.1 - 4.1e-18 64.9 0.5 5.8e-18 64.4 0.4 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain eIF-5a PF01287.15 KII73229.1 - 0.025 14.5 0.6 0.052 13.5 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold E2F_TDP PF02319.15 KII73231.1 - 1.1e-24 85.7 0.4 2.3e-24 84.7 0.2 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DP PF08781.5 KII73231.1 - 6.1e-22 77.8 0.9 2.2e-21 76.0 0.2 2.2 2 0 0 2 2 2 1 Transcription factor DP Condensin2nSMC PF12422.3 KII73231.1 - 0.063 13.0 0.1 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit DUF4320 PF14208.1 KII73231.1 - 0.12 12.3 0.9 2.6 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) DDE_Tnp_IS1595 PF12762.2 KII73232.1 - 5.1e-19 68.5 0.0 5.9e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain IPP-2 PF04979.9 KII73233.1 - 6.4e-19 68.4 2.5 1.4e-18 67.4 1.7 1.5 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) GCR1_C PF12550.3 KII73234.1 - 0.041 13.7 0.3 0.07 13.0 0.2 1.5 1 1 0 1 1 1 0 Transcriptional activator of glycolytic enzymes HTH_23 PF13384.1 KII73234.1 - 0.042 13.5 0.0 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain LytR_cpsA_psr PF03816.9 KII73234.1 - 0.081 12.8 0.4 0.084 12.7 0.3 1.2 1 0 0 1 1 1 0 Cell envelope-related transcriptional attenuator domain DEAD PF00270.24 KII73235.1 - 3.2e-26 91.8 0.1 6.8e-25 87.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII73235.1 - 7.1e-19 67.4 0.1 1.7e-18 66.2 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII73235.1 - 3e-11 43.5 0.3 1.1e-09 38.4 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KII73235.1 - 0.0033 17.5 0.0 0.0087 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain IGR PF09597.5 KII73235.1 - 0.044 13.6 0.3 0.19 11.6 0.2 2.1 1 1 0 1 1 1 0 IGR protein motif DUF4137 PF13593.1 KII73235.1 - 0.18 10.8 0.1 0.26 10.3 0.1 1.2 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) TraG-D_C PF12696.2 KII73235.1 - 0.22 11.3 2.2 0.82 9.5 0.3 2.2 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG AAA PF00004.24 KII73235.1 - 0.34 11.1 2.5 1.2 9.3 0.6 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) tRNA-synt_1c PF00749.16 KII73236.1 - 1.2e-95 319.8 1.2 1.8e-95 319.2 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 KII73236.1 - 3e-27 95.4 1.8 4.4e-27 94.8 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_2b PF00587.20 KII73236.1 - 1.5e-19 70.1 0.0 3.6e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KII73236.1 - 5.2e-19 67.9 0.0 1.8e-18 66.2 0.0 2.0 1 0 0 1 1 1 1 Anticodon binding domain ProRS-C_1 PF09180.6 KII73236.1 - 8.8e-15 54.3 1.1 8.8e-15 54.3 0.8 2.2 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal GST_C PF00043.20 KII73236.1 - 4.1e-05 23.4 0.0 0.00012 21.9 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Vmethyltransf_C PF08456.5 KII73238.1 - 0.079 12.3 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Viral methyltransferase C-terminal Mito_carr PF00153.22 KII73239.1 - 8.9e-57 188.8 3.4 1.4e-21 76.0 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein PLAC8 PF04749.12 KII73240.1 - 4.1e-23 81.9 10.3 4.7e-23 81.7 7.2 1.0 1 0 0 1 1 1 1 PLAC8 family Tmemb_9 PF05434.6 KII73241.1 - 0.0013 18.5 0.7 0.0024 17.6 0.5 1.4 1 0 0 1 1 1 1 TMEM9 DUF1240 PF06836.7 KII73241.1 - 0.053 13.7 2.7 0.15 12.3 1.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1240) SRF-TF PF00319.13 KII73242.1 - 1.3e-21 75.5 0.1 2.2e-21 74.8 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ion_trans PF00520.26 KII73243.1 - 0.02 14.1 4.1 0.027 13.7 1.2 2.1 2 0 0 2 2 2 0 Ion transport protein Ldl_recept_a PF00057.13 KII73244.1 - 1.4e-09 37.6 11.0 3.7e-09 36.3 7.6 1.7 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A PrgI PF12666.2 KII73245.1 - 0.0036 17.4 0.5 0.0052 16.9 0.3 1.3 1 0 0 1 1 1 1 PrgI family protein Ribosomal_L2 PF00181.18 KII73246.1 - 6.3e-18 64.5 0.1 6.3e-18 64.5 0.1 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C PF03947.13 KII73246.1 - 1.7e-11 44.0 0.0 4.4e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain SelP_N PF04592.9 KII73247.1 - 1.7 7.9 10.6 1.9 7.7 7.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FGF-BP1 PF06473.7 KII73247.1 - 4.3 6.8 11.4 5.6 6.4 7.9 1.1 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Ribosomal_S17 PF00366.15 KII73248.1 - 0.055 13.5 0.0 0.12 12.4 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein S17 BPL_LplA_LipB PF03099.14 KII73249.1 - 0.00043 20.2 0.0 0.00071 19.5 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF814 PF05670.8 KII73249.1 - 0.039 13.8 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF814) Ribosomal_L16 PF00252.13 KII73251.1 - 2.1e-06 27.5 0.0 3.6e-06 26.7 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L16p/L10e HTH_45 PF14947.1 KII73251.1 - 0.11 12.3 0.1 0.31 10.8 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix BSD PF03909.12 KII73252.1 - 3.1e-05 23.6 0.1 3.1e-05 23.6 0.1 1.8 3 0 0 3 3 3 1 BSD domain DUF3868 PF12984.2 KII73254.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3868) Proteasome PF00227.21 KII73255.1 - 1.3e-31 109.3 0.0 1.5e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit FtsK_SpoIIIE_N PF12538.3 KII73255.1 - 0.045 13.8 0.0 0.074 13.1 0.0 1.3 1 0 0 1 1 1 0 DNA transporter Aldolase_II PF00596.16 KII73256.1 - 2e-19 69.9 0.0 4.3e-19 68.8 0.0 1.6 2 0 0 2 2 2 1 Class II Aldolase and Adducin N-terminal domain Kelch_5 PF13854.1 KII73257.1 - 2.2e-20 72.1 1.5 2.5e-08 33.7 0.1 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 KII73257.1 - 1.6e-16 59.6 5.7 0.0027 17.8 0.0 5.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII73257.1 - 9.2e-16 57.3 5.3 0.00052 19.7 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73257.1 - 7.2e-15 54.2 14.4 4.1e-05 23.0 0.4 5.3 4 1 0 4 4 4 4 Kelch motif Kelch_3 PF13415.1 KII73257.1 - 3.1e-11 43.0 1.0 0.043 14.0 0.0 5.9 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII73257.1 - 0.00026 20.6 10.0 0.53 10.1 0.0 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.20 KII73258.1 - 3.5e-27 93.6 17.1 1.1e-06 28.1 0.2 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII73258.1 - 3.5e-23 81.0 7.7 5e-05 22.9 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KII73258.1 - 3e-21 74.6 13.7 0.00011 22.1 0.0 6.8 5 2 1 6 6 6 5 Kelch motif Kelch_5 PF13854.1 KII73258.1 - 7.9e-16 57.6 6.5 1.4e-05 24.8 0.1 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 KII73258.1 - 5.2e-13 48.7 10.7 0.0077 16.3 0.0 6.6 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KII73258.1 - 1.5e-09 37.2 16.4 0.053 13.3 0.2 6.6 7 0 0 7 7 7 4 Kelch motif DUF4062 PF13271.1 KII73258.1 - 0.021 14.8 0.0 2.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4062) Kelch_4 PF13418.1 KII73259.1 - 0.00083 19.0 0.4 0.67 9.7 0.2 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73259.1 - 0.011 15.2 0.1 2 8.0 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.1 KII73259.1 - 0.073 13.2 0.1 9.5 6.5 0.0 2.5 2 1 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.1 KII73260.1 - 3.6e-14 52.2 7.2 3.2e-06 27.0 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII73260.1 - 2e-13 49.8 1.5 0.002 17.8 0.1 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII73260.1 - 1.9e-12 46.8 6.9 5e-06 26.3 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII73260.1 - 1.3e-10 41.1 3.6 0.0017 18.4 0.2 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73260.1 - 7.3e-09 35.0 10.3 1.8e-05 24.1 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 KII73260.1 - 0.0024 17.5 9.8 0.011 15.4 0.1 3.4 2 2 1 3 3 3 1 Kelch motif Kelch_6 PF13964.1 KII73261.1 - 1.2e-10 41.0 1.2 0.00011 22.1 0.0 3.4 2 1 1 3 3 3 2 Kelch motif Kelch_1 PF01344.20 KII73261.1 - 1.1e-06 28.0 7.2 1.2e-05 24.7 0.2 2.8 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 KII73261.1 - 1.1e-06 28.2 1.1 3.5e-05 23.4 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII73261.1 - 5.2e-06 26.0 1.3 0.0081 15.8 0.5 2.9 2 1 0 2 2 2 2 Kelch motif Kelch_5 PF13854.1 KII73261.1 - 1.3e-05 24.9 1.6 0.0014 18.5 0.1 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.1 KII73261.1 - 0.00019 21.4 0.1 0.14 12.4 0.1 2.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Cep57_MT_bd PF06657.8 KII73262.1 - 0.047 13.6 0.1 0.047 13.6 0.1 3.0 3 1 1 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Inp1 PF12634.2 KII73262.1 - 0.073 12.7 0.9 0.16 11.6 0.6 1.6 1 0 0 1 1 1 0 Inheritance of peroxisomes protein 1 TSC22 PF01166.13 KII73262.1 - 3.5 7.6 8.1 13 5.8 1.5 3.1 2 1 0 2 2 2 0 TSC-22/dip/bun family SEP PF08059.8 KII73263.1 - 2e-11 44.0 0.1 3.8e-11 43.1 0.1 1.4 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.1 KII73263.1 - 1.3e-05 24.5 0.2 2.2e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.15 KII73263.1 - 0.0016 18.4 0.0 0.0034 17.4 0.0 1.6 1 0 0 1 1 1 1 UBX domain BNR PF02012.15 KII73264.1 - 0.061 13.1 0.0 7.8 6.7 0.0 3.4 3 0 0 3 3 3 0 BNR/Asp-box repeat Homeobox PF00046.24 KII73266.1 - 5e-19 67.6 3.4 7.9e-19 67.0 2.4 1.3 1 0 0 1 1 1 1 Homeobox domain ETRAMP PF09716.5 KII73269.1 - 0.18 11.7 2.0 0.3 11.0 0.8 1.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DDE_3 PF13358.1 KII73270.1 - 5.1e-29 100.8 0.0 8.8e-29 100.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII73270.1 - 1.6e-05 24.9 0.0 3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HTH_23 PF13384.1 KII73270.1 - 0.00016 21.2 0.2 0.0054 16.3 0.0 2.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII73270.1 - 0.0004 20.3 0.5 0.00086 19.2 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KII73270.1 - 0.0026 17.8 0.2 0.011 15.8 0.1 2.0 2 0 0 2 2 2 1 Winged helix-turn helix DDE_1 PF03184.14 KII73270.1 - 0.0027 16.9 0.1 0.0057 15.8 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_38 PF13936.1 KII73270.1 - 0.003 17.0 3.8 1.3 8.6 0.3 2.8 3 0 0 3 3 3 2 Helix-turn-helix domain HTH_5 PF01022.15 KII73270.1 - 0.0052 16.4 0.3 0.026 14.1 0.0 2.3 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family DDE_Tnp_ISAZ013 PF07592.6 KII73270.1 - 0.014 14.1 0.5 1.7 7.3 0.0 2.4 3 0 0 3 3 3 0 Rhodopirellula transposase DDE domain HTH_Tnp_Tc3_2 PF01498.13 KII73270.1 - 0.015 15.3 0.1 0.04 13.9 0.1 1.7 1 0 0 1 1 1 0 Transposase HTH_Tnp_1 PF01527.15 KII73270.1 - 0.034 14.0 0.2 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Transposase DUF1662 PF07878.6 KII73270.1 - 0.077 12.7 0.3 0.21 11.3 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1662) MFS_1 PF07690.11 KII73271.1 - 1.5e-36 125.8 29.9 2.1e-33 115.5 20.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 KII73271.1 - 0.0096 15.9 0.8 0.035 14.1 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1228) PhrC_PhrF PF11131.3 KII73271.1 - 0.14 11.7 1.0 0.38 10.3 0.7 1.8 1 0 0 1 1 1 0 Rap-phr extracellular signalling MULE PF10551.4 KII73272.1 - 1.7e-08 34.5 0.1 1.2e-07 31.8 0.0 2.4 2 0 0 2 2 2 1 MULE transposase domain DUF2347 PF09804.4 KII73272.1 - 0.046 12.9 0.0 0.066 12.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DDE_Tnp_ISL3 PF01610.12 KII73272.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Transposase DDE_3 PF13358.1 KII73273.1 - 3.4e-11 43.0 0.1 6.6e-11 42.1 0.1 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII73273.1 - 0.079 12.5 0.2 0.25 10.9 0.1 1.8 1 1 1 2 2 2 0 Winged helix-turn helix MRP-L27 PF09809.4 KII73275.1 - 1.2e-07 31.3 0.6 1.7e-07 30.8 0.3 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L27 Ca_hom_mod PF14798.1 KII73276.1 - 0.00072 18.5 2.1 0.0016 17.4 1.5 1.6 1 1 0 1 1 1 1 Calcium homeostasis modulator MacB_PCD PF12704.2 KII73276.1 - 5 6.6 5.8 1.8 8.0 0.1 2.1 1 1 1 2 2 2 0 MacB-like periplasmic core domain BPL_N PF09825.4 KII73277.1 - 0.26 10.0 2.0 0.29 9.8 1.4 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Ribosomal_S20p PF01649.13 KII73277.1 - 0.45 10.9 4.6 0.29 11.5 1.9 1.6 1 1 0 1 1 1 0 Ribosomal protein S20 DUF4250 PF14056.1 KII73278.1 - 0.066 12.9 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) Filament PF00038.16 KII73279.1 - 0.00036 20.1 12.2 0.00042 19.8 8.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein ENT PF03735.9 KII73279.1 - 0.04 13.6 1.3 0.04 13.6 0.9 2.2 2 0 0 2 2 2 0 ENT domain DUF1804 PF08822.6 KII73279.1 - 0.07 12.8 1.6 0.07 12.8 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1804) AAA_13 PF13166.1 KII73279.1 - 0.081 11.3 13.0 0.11 10.9 9.0 1.1 1 0 0 1 1 1 0 AAA domain SNARE PF05739.14 KII73279.1 - 0.085 12.5 5.7 0.15 11.7 0.4 2.7 1 1 2 3 3 3 0 SNARE domain IMD PF08397.6 KII73279.1 - 0.16 11.2 8.9 0.2 10.9 6.2 1.1 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF4026 PF13218.1 KII73279.1 - 0.18 10.6 4.7 0.19 10.5 2.9 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4026) LcrG PF07216.7 KII73279.1 - 0.23 11.4 1.6 1 9.4 0.0 2.1 1 1 1 2 2 2 0 LcrG protein APG6 PF04111.7 KII73279.1 - 0.35 9.8 13.0 0.43 9.5 9.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4419 PF14388.1 KII73279.1 - 0.35 10.0 4.2 0.49 9.5 2.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4419) FlgN PF05130.7 KII73279.1 - 0.97 9.6 6.5 1.3 9.2 4.5 1.2 1 0 0 1 1 1 0 FlgN protein IncA PF04156.9 KII73279.1 - 1.8 8.1 13.1 3 7.4 9.1 1.3 1 0 0 1 1 1 0 IncA protein OEP PF02321.13 KII73279.1 - 1.9 8.0 5.9 3.1 7.3 4.1 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein CENP-Q PF13094.1 KII73279.1 - 2.6 8.0 10.8 5.2 7.0 0.2 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Phe_tRNA-synt_N PF02912.13 KII73279.1 - 2.8 7.7 6.4 4.6 7.0 1.0 2.2 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain Med4 PF10018.4 KII73279.1 - 3.2 7.0 11.0 1.2 8.4 1.1 2.2 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 SlyX PF04102.7 KII73279.1 - 7.5 7.0 9.1 8.8 6.7 0.8 3.0 1 1 2 3 3 3 0 SlyX Sec1 PF00995.18 KII73280.1 - 2e-68 231.4 14.7 3.9e-67 227.1 10.2 2.0 1 1 0 1 1 1 1 Sec1 family Complex1_LYR_2 PF13233.1 KII73280.1 - 0.12 12.8 1.0 4.5 7.8 0.3 2.7 2 1 0 2 2 2 0 Complex1_LYR-like MutS_III PF05192.13 KII73280.1 - 0.37 10.5 5.0 0.41 10.3 2.6 1.7 1 1 0 2 2 2 0 MutS domain III DUF972 PF06156.8 KII73280.1 - 3.7 7.9 6.3 51 4.2 4.4 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF972) RRM_6 PF14259.1 KII73281.1 - 3.8e-10 39.5 0.1 1.4e-05 24.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KII73281.1 - 4.5e-09 35.7 0.2 0.0012 18.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII73281.1 - 0.00063 19.5 0.0 0.21 11.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3753 PF12575.3 KII73282.1 - 0.086 12.6 0.3 9.9 6.0 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) tRNA-synt_1e PF01406.14 KII73283.1 - 1.8e-27 96.2 0.6 2.3e-27 95.9 0.4 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 KII73283.1 - 0.0035 16.0 0.0 0.0045 15.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 KII73283.1 - 0.0045 15.0 0.0 0.0053 14.8 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 KII73284.1 - 3.4e-31 108.4 0.8 4.4e-31 108.1 0.5 1.3 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 KII73284.1 - 0.0019 16.9 0.1 0.0023 16.6 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) CDC37_M PF08565.6 KII73284.1 - 0.036 13.5 0.3 0.051 13.0 0.2 1.2 1 0 0 1 1 1 0 Cdc37 Hsp90 binding domain DUF3827 PF12877.2 KII73285.1 - 0.0093 14.1 1.2 0.013 13.6 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) TMEM154 PF15102.1 KII73285.1 - 0.04 13.6 0.1 0.097 12.3 0.0 1.6 2 0 0 2 2 2 0 TMEM154 protein family Podoplanin PF05808.6 KII73285.1 - 0.05 13.1 0.4 0.081 12.4 0.3 1.3 1 0 0 1 1 1 0 Podoplanin DUF4064 PF13273.1 KII73285.1 - 0.054 13.5 1.7 0.19 11.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) PepSY_TM_2 PF13703.1 KII73285.1 - 0.09 12.9 1.1 0.21 11.7 0.7 1.6 1 0 0 1 1 1 0 PepSY-associated TM helix DUF4448 PF14610.1 KII73285.1 - 0.15 11.5 0.4 0.3 10.5 0.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Rifin_STEVOR PF02009.11 KII73285.1 - 0.16 11.5 0.6 0.22 11.1 0.3 1.2 1 1 0 1 1 1 0 Rifin/stevor family zf-LITAF-like PF10601.4 KII73285.1 - 0.26 11.1 1.3 1 9.2 0.1 2.2 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain EphA2_TM PF14575.1 KII73285.1 - 0.57 10.6 4.7 5.3 7.5 1.8 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain zf-B_box PF00643.19 KII73286.1 - 0.0045 16.8 0.9 0.0063 16.3 0.6 1.2 1 0 0 1 1 1 1 B-box zinc finger Tnp_zf-ribbon_2 PF13842.1 KII73286.1 - 0.066 13.6 2.7 0.14 12.6 1.9 1.5 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon GFA PF04828.9 KII73286.1 - 0.32 10.9 2.1 0.67 9.9 1.5 1.9 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme zf-NADH-PPase PF09297.6 KII73286.1 - 5 6.7 7.7 19 4.8 1.4 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain rve PF00665.21 KII73289.1 - 2.2e-26 92.3 0.0 5.5e-26 91.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII73289.1 - 0.0095 15.4 2.5 0.017 14.6 0.0 2.7 3 0 0 3 3 3 1 Integrase core domain IBP39 PF11422.3 KII73289.1 - 0.028 13.9 0.9 0.054 12.9 0.6 1.5 1 0 0 1 1 1 0 Initiator binding protein 39 kDa RVT_1 PF00078.22 KII73290.1 - 5.6e-22 78.1 0.8 8.7e-22 77.5 0.6 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glycoprotein PF03409.10 KII73292.1 - 0.039 12.6 0.0 0.047 12.4 0.0 1.1 1 0 0 1 1 1 0 Transmembrane glycoprotein PUA PF01472.15 KII73293.1 - 0.13 12.0 0.0 19 5.0 0.0 2.2 1 1 1 2 2 2 0 PUA domain SNAP PF14938.1 KII73295.1 - 6.2e-16 58.3 4.5 8.3e-16 57.9 2.9 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 KII73295.1 - 0.095 12.3 1.8 0.78 9.4 0.6 2.7 1 1 2 3 3 3 0 TPR repeat TPR_8 PF13181.1 KII73295.1 - 0.24 11.2 7.2 6.3 6.8 0.1 4.9 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII73295.1 - 0.51 10.0 7.0 69 3.2 0.0 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat LSR PF05624.9 KII73298.1 - 0.19 11.4 1.9 0.33 10.7 1.3 1.3 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) DDE_1 PF03184.14 KII73299.1 - 2.5e-09 36.5 0.0 3e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Endonuc-BglII PF09195.6 KII73301.1 - 0.12 11.7 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease BglII DDE_3 PF13358.1 KII73302.1 - 1.1e-06 28.4 0.1 0.0089 15.7 0.0 3.1 1 1 2 3 3 3 3 DDE superfamily endonuclease Rad60-SLD_2 PF13881.1 KII73303.1 - 0.084 12.7 0.0 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Herpes_UL20 PF04544.7 KII73304.1 - 0.071 12.9 0.2 0.7 9.6 0.0 2.0 1 1 1 2 2 2 0 Herpesvirus egress protein UL20 DSRB PF10781.4 KII73305.1 - 0.017 14.5 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Dextransucrase DSRB DUF3024 PF11225.3 KII73305.1 - 0.082 12.7 0.0 2.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3024) rve PF00665.21 KII73306.1 - 5.3e-26 91.0 0.0 9.5e-26 90.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII73306.1 - 0.00035 20.0 0.0 0.00068 19.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII73306.1 - 0.00039 19.8 0.0 0.00095 18.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII73306.1 - 0.0094 15.3 0.1 0.018 14.4 0.1 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger UN_NPL4 PF11543.3 KII73306.1 - 0.068 13.4 0.1 0.5 10.6 0.0 2.3 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 Spheroidin PF05541.7 KII73307.1 - 0.1 10.2 0.5 0.1 10.1 0.3 1.1 1 0 0 1 1 1 0 Entomopoxvirus spheroidin protein Podovirus_Gp16 PF05894.7 KII73308.1 - 0.0028 17.0 0.1 0.0031 16.9 0.1 1.0 1 0 0 1 1 1 1 Podovirus DNA encapsidation protein (Gp16) Glyco_tranf_2_5 PF13712.1 KII73308.1 - 0.016 14.4 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family CedA PF10729.4 KII73308.1 - 0.036 13.5 0.0 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 Cell division activator CedA DnaJ PF00226.26 KII73310.1 - 6.9e-20 70.5 2.3 6.9e-20 70.5 1.6 2.0 2 0 0 2 2 2 1 DnaJ domain AF1Q PF15017.1 KII73310.1 - 0.031 14.1 1.1 6.6 6.7 0.0 2.6 2 0 0 2 2 2 0 Drug resistance and apoptosis regulator SSPI PF14098.1 KII73310.1 - 0.096 12.6 0.8 0.5 10.3 0.0 2.5 3 0 0 3 3 3 0 Small, acid-soluble spore protein I Fucose_iso_N2 PF07882.7 KII73310.1 - 0.88 9.2 7.0 0.14 11.7 1.7 2.0 2 1 0 2 2 2 0 L-fucose isomerase, second N-terminal domain zf-P11 PF03854.9 KII73311.1 - 0.022 14.2 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 P-11 zinc finger Transglut_N PF00868.15 KII73313.1 - 0.036 14.1 0.0 0.043 13.8 0.0 1.2 1 0 0 1 1 1 0 Transglutaminase family TSLP PF15216.1 KII73314.1 - 0.067 12.9 0.2 0.14 11.8 0.1 1.6 1 1 0 1 1 1 0 Thymic stromal lymphopoietin Exo_endo_phos_2 PF14529.1 KII73318.1 - 5.4e-05 22.7 0.7 8.7e-05 22.1 0.2 1.6 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase DUF4370 PF14290.1 KII73318.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4370) rve PF00665.21 KII73320.1 - 5e-26 91.1 0.0 1e-25 90.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII73320.1 - 0.00031 20.7 0.4 0.0027 17.7 0.0 2.6 3 0 0 3 3 3 1 DDE domain rve_3 PF13683.1 KII73320.1 - 0.0017 17.8 0.4 0.009 15.5 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain PhoQ_Sensor PF08918.5 KII73324.1 - 0.039 13.4 0.1 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 PhoQ Sensor SAP18 PF06487.7 KII73325.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.5 1 1 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) UCH PF00443.24 KII73330.1 - 6.6e-48 163.1 16.7 1.9e-46 158.3 11.6 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KII73330.1 - 3.3e-17 62.8 21.3 6.9e-14 51.9 14.7 2.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-AD PF07776.10 KII73330.1 - 2.9 7.9 10.8 0.58 10.1 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) Abhydrolase_6 PF12697.2 KII73331.1 - 1.4e-08 34.9 0.0 2.5e-05 24.2 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KII73331.1 - 5.2e-07 29.5 0.0 8.6e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KII73331.1 - 0.00012 21.7 0.0 0.0021 17.6 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 KII73331.1 - 0.014 14.8 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase BAAT_C PF08840.6 KII73331.1 - 0.16 11.6 0.0 2 8.0 0.0 2.0 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abi PF02517.11 KII73332.1 - 0.056 13.5 0.0 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 CAAX protease self-immunity DUF4371 PF14291.1 KII73333.1 - 0.037 13.5 0.2 0.065 12.7 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4371) PRKCSH PF07915.8 KII73334.1 - 3.4e-08 34.1 0.7 3.4e-08 34.1 0.5 1.7 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.1 KII73334.1 - 2.4e-06 27.1 0.3 5.1e-06 26.0 0.2 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein DUF1030 PF06270.6 KII73334.1 - 0.11 12.0 0.0 0.25 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1030) ThiF PF00899.16 KII73336.1 - 8.1e-42 142.2 0.1 1.3e-31 109.2 0.0 2.5 2 0 0 2 2 2 2 ThiF family UBACT PF02134.16 KII73336.1 - 1.4e-30 104.6 3.2 9.9e-26 89.1 0.1 3.6 3 0 0 3 3 3 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_C PF09358.5 KII73336.1 - 2e-28 99.0 0.0 4.4e-28 97.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain UBA_e1_thiolCys PF10585.4 KII73336.1 - 3.8e-22 77.3 1.8 2.1e-21 75.0 0.3 2.5 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site Glyco_hydro_15 PF00723.16 KII73340.1 - 0.00026 19.6 0.0 0.0003 19.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Orthopox_F7 PF05813.7 KII73340.1 - 0.15 11.9 1.0 6.2 6.7 0.0 2.2 1 1 1 2 2 2 0 Orthopoxvirus F7 protein Glyco_hydro_15 PF00723.16 KII73341.1 - 2.9e-19 68.9 0.3 4.8e-16 58.3 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 15 Chrome_Resist PF09828.4 KII73343.1 - 0.057 13.6 0.0 0.26 11.4 0.0 2.2 1 0 0 1 1 1 0 Chromate resistance exported protein Ribosomal_S8e PF01201.17 KII73344.1 - 5.9e-11 42.6 0.0 6.7e-10 39.2 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S8e SHS2_FTSA PF02491.15 KII73345.1 - 0.024 14.4 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 SHS2 domain inserted in FTSA DHHA1 PF02272.14 KII73345.1 - 0.073 12.7 0.2 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 DHHA1 domain DZR PF12773.2 KII73346.1 - 0.079 12.7 0.4 0.19 11.5 0.3 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-CCHC_6 PF15288.1 KII73346.1 - 0.12 12.0 0.3 0.24 11.1 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle PAS_11 PF14598.1 KII73347.1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 PAS domain AdoHcyase PF05221.12 KII73348.1 - 2.4e-28 98.8 0.0 2.6e-28 98.7 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KII73348.1 - 1.9e-16 60.3 0.0 2.8e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.12 KII73349.1 - 7.8e-50 169.3 0.1 8.5e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KII73350.1 - 3.2e-28 98.6 0.5 3.8e-28 98.3 0.3 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.12 KII73350.1 - 9.3e-07 28.0 0.0 9.7e-07 27.9 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase THF_DHG_CYH_C PF02882.14 KII73350.1 - 0.0021 17.1 0.4 0.0032 16.5 0.3 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF2345 PF10106.4 KII73350.1 - 0.0095 15.5 0.1 0.02 14.5 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2345) OCD_Mu_crystall PF02423.10 KII73350.1 - 0.082 11.6 0.2 0.094 11.4 0.2 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family AdoHcyase_NAD PF00670.16 KII73351.1 - 1.2e-34 119.5 0.3 1.5e-34 119.1 0.2 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.12 KII73351.1 - 2.8e-08 33.0 0.0 2.9e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase THF_DHG_CYH_C PF02882.14 KII73351.1 - 0.068 12.2 0.3 0.11 11.5 0.2 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.14 KII73351.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Malic_M PF03949.10 KII73351.1 - 0.13 11.7 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain AdoHcyase PF05221.12 KII73352.1 - 1.7e-16 60.0 0.0 1.8e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KII73352.1 - 1.3e-06 28.3 0.0 2.1e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF2753 PF10952.3 KII73352.1 - 0.034 14.1 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) AdoHcyase PF05221.12 KII73354.1 - 2.6e-60 203.6 0.1 2.9e-60 203.4 0.1 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KII73354.1 - 1.1e-54 184.6 3.3 1.5e-54 184.1 2.3 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 KII73354.1 - 1.1e-07 31.2 0.1 2.1e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 KII73354.1 - 3.9e-05 23.0 0.6 5.9e-05 22.5 0.4 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 KII73354.1 - 0.00013 21.9 0.4 0.00057 19.8 0.3 2.1 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.1 KII73354.1 - 0.0053 16.9 0.3 0.033 14.4 0.1 2.2 2 1 0 2 2 2 1 Putative NAD(P)-binding UDPG_MGDP_dh_C PF03720.10 KII73354.1 - 0.01 15.9 0.0 0.04 14.0 0.0 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Malic_M PF03949.10 KII73354.1 - 0.037 13.5 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain THF_DHG_CYH_C PF02882.14 KII73354.1 - 0.039 13.0 2.3 0.19 10.8 1.6 1.9 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF2753 PF10952.3 KII73354.1 - 0.053 13.5 0.1 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) E1_DerP2_DerF2 PF02221.10 KII73355.1 - 0.0038 17.4 0.2 0.0058 16.8 0.1 1.2 1 0 0 1 1 1 1 ML domain AdoHcyase_NAD PF00670.16 KII73356.1 - 9.8e-35 119.7 0.4 1.4e-34 119.3 0.2 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.12 KII73356.1 - 7.7e-28 97.1 0.0 7.9e-28 97.1 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase Malic_M PF03949.10 KII73356.1 - 0.053 13.0 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain THF_DHG_CYH_C PF02882.14 KII73356.1 - 0.07 12.2 0.5 0.13 11.3 0.4 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.14 KII73356.1 - 0.072 12.2 0.0 0.19 10.8 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.10 KII73356.1 - 0.15 10.7 0.4 0.21 10.2 0.3 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family AdoHcyase PF05221.12 KII73357.1 - 5.4e-60 202.6 0.1 5.9e-60 202.4 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 KII73357.1 - 2.8e-06 27.2 0.0 6.8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF2753 PF10952.3 KII73357.1 - 0.04 13.8 0.0 0.08 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) Siah-Interact_N PF09032.6 KII73361.1 - 0.01 15.9 0.3 0.015 15.3 0.2 1.2 1 0 0 1 1 1 1 Siah interacting protein, N terminal 7tm_1 PF00001.16 KII73365.1 - 2.8e-06 26.6 3.3 2.8e-06 26.6 2.3 1.8 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF2953 PF11167.3 KII73365.1 - 2.3 8.2 4.4 11 5.9 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2953) ApoL PF05461.6 KII73366.1 - 0.048 12.9 0.0 0.051 12.8 0.0 1.0 1 0 0 1 1 1 0 Apolipoprotein L DDE_3 PF13358.1 KII73367.1 - 0.083 12.6 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease 7tm_1 PF00001.16 KII73369.1 - 4.3e-17 62.0 22.3 6.3e-17 61.5 15.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Sru PF10322.4 KII73369.1 - 0.00024 20.3 18.4 0.00024 20.3 12.7 2.6 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Sru DUF202 PF02656.10 KII73369.1 - 9.9 6.4 7.9 4.3 7.6 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF202) rve PF00665.21 KII73370.1 - 5.2e-07 29.8 0.0 9.5e-06 25.7 0.0 2.2 1 1 0 1 1 1 1 Integrase core domain Turandot PF07240.6 KII73373.1 - 0.0072 15.7 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Stress-inducible humoral factor Turandot Gypsy PF07253.6 KII73374.1 - 0.032 12.5 1.5 0.04 12.2 1.0 1.0 1 0 0 1 1 1 0 Gypsy protein DUF4325 PF14213.1 KII73374.1 - 0.17 11.5 1.4 2.3 7.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4325) TFIIA PF03153.8 KII73376.1 - 2e-32 113.5 4.6 4.7e-31 109.0 3.2 2.0 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DsbC PF11412.3 KII73378.1 - 0.047 13.5 0.1 0.18 11.6 0.0 1.8 1 1 1 2 2 2 0 Disulphide bond corrector protein DsbC Claudin_2 PF13903.1 KII73378.1 - 0.097 12.3 0.1 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF1866 PF08952.6 KII73378.1 - 0.12 11.8 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) zf-CCHC PF00098.18 KII73379.1 - 0.00018 21.2 1.7 0.00027 20.7 1.2 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.1 KII73379.1 - 0.00027 20.3 1.1 0.00043 19.6 0.7 1.3 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 KII73379.1 - 0.021 14.4 1.5 0.037 13.7 0.6 1.8 2 0 0 2 2 2 0 Zinc knuckle BNR PF02012.15 KII73382.1 - 0.00048 19.5 1.5 0.24 11.3 0.0 4.3 4 0 0 4 4 4 2 BNR/Asp-box repeat MtlR PF05068.7 KII73383.1 - 0.063 12.7 0.1 0.08 12.3 0.0 1.1 1 0 0 1 1 1 0 Mannitol repressor DUF3102 PF11300.3 KII73384.1 - 0.043 13.8 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3102) DDE_Tnp_IS1595 PF12762.2 KII73387.1 - 2.8e-15 56.4 0.1 3.2e-15 56.2 0.1 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain PAZ PF02170.17 KII73388.1 - 0.067 12.5 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 PAZ domain Hexokinase_2 PF03727.11 KII73389.1 - 3.6e-31 108.2 0.0 4.3e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 KII73390.1 - 4.1e-55 186.2 0.0 5.2e-55 185.9 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 KII73390.1 - 2.9e-06 26.6 0.1 4.3e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Hexokinase DUF2805 PF10985.3 KII73390.1 - 0.059 13.3 0.0 0.8 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2805) MMtag PF10159.4 KII73393.1 - 3.1e-21 75.2 0.0 3.1e-21 75.2 0.0 2.0 2 0 0 2 2 2 1 Kinase phosphorylation protein Retrotrans_gag PF03732.12 KII73394.1 - 0.07 13.2 0.0 0.089 12.8 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon gag protein DUF3677 PF12432.3 KII73395.1 - 2.3e-06 27.9 0.5 1.4e-05 25.4 0.3 2.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3677) PSD3 PF07626.6 KII73395.1 - 0.071 13.1 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1587) AAA_18 PF13238.1 KII73396.1 - 0.026 14.8 0.3 0.039 14.2 0.2 1.3 1 0 0 1 1 1 0 AAA domain WD40 PF00400.27 KII73397.1 - 8.6e-15 53.9 8.6 8.8e-06 25.4 0.1 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat Adeno_hexon PF01065.14 KII73399.1 - 0.07 11.9 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Hexon, adenovirus major coat protein, N-terminal domain zf-AN1 PF01428.11 KII73403.1 - 3e-09 36.5 14.7 3e-09 36.5 10.2 2.2 2 0 0 2 2 2 1 AN1-like Zinc finger zf-A20 PF01754.11 KII73403.1 - 0.005 16.3 1.1 0.005 16.3 0.8 3.3 4 0 0 4 4 4 1 A20-like zinc finger Phage_T4_gp36 PF03903.8 KII73403.1 - 0.073 13.1 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Phage T4 tail fibre Laminin_G_3 PF13385.1 KII73405.1 - 9e-17 61.7 0.4 1.2e-16 61.2 0.3 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.12 KII73405.1 - 1.2e-05 24.9 0.0 0.00015 21.2 0.0 2.1 1 1 0 1 1 1 1 Pentaxin family Cation_efflux PF01545.16 KII73406.1 - 1.4e-55 188.4 9.0 1.7e-55 188.1 6.3 1.1 1 0 0 1 1 1 1 Cation efflux family MerC PF03203.9 KII73406.1 - 0.0069 16.7 0.4 2.4 8.5 0.0 2.7 2 1 0 2 2 2 2 MerC mercury resistance protein GHMP_kinases_N PF00288.21 KII73407.1 - 4.1e-17 62.0 0.3 7.1e-17 61.2 0.2 1.4 1 0 0 1 1 1 1 GHMP kinases N terminal domain GalKase_gal_bdg PF10509.4 KII73408.1 - 0.086 12.1 0.0 0.18 11.0 0.0 1.7 2 0 0 2 2 2 0 Galactokinase galactose-binding signature RVT_1 PF00078.22 KII73409.1 - 0.00035 19.9 0.3 0.00047 19.5 0.2 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Claudin_2 PF13903.1 KII73414.1 - 0.003 17.2 5.7 0.003 17.2 4.0 2.5 1 1 1 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction DUF4231 PF14015.1 KII73414.1 - 0.0049 16.8 2.7 0.056 13.4 0.3 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF4231) PI3_PI4_kinase PF00454.22 KII73415.1 - 6.3e-32 110.9 0.0 1.2e-20 73.9 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 KII73415.1 - 0.001 18.2 0.3 0.049 12.7 0.0 2.3 1 1 1 2 2 2 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.1 KII73415.1 - 0.0021 17.1 0.0 0.0043 16.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) DUF3196 PF11428.3 KII73415.1 - 0.022 14.0 0.4 2.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3196) Sybindin PF04099.7 KII73418.1 - 0.12 12.0 0.9 0.53 9.9 0.1 2.1 1 1 1 2 2 2 0 Sybindin-like family ERCC4 PF02732.10 KII73419.1 - 9.4e-26 90.2 0.5 2e-25 89.2 0.3 1.6 2 0 0 2 2 2 1 ERCC4 domain HHH_8 PF14716.1 KII73419.1 - 0.0033 17.5 0.0 0.12 12.5 0.0 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain Arrestin_C PF02752.17 KII73419.1 - 0.047 13.7 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain Sugar-bind PF04198.8 KII73420.1 - 0.11 11.3 0.0 0.26 10.1 0.0 1.5 1 1 1 2 2 2 0 Putative sugar-binding domain Calponin PF00402.13 KII73423.1 - 5.7 6.3 5.9 1.1 8.6 0.5 2.5 2 1 0 2 2 2 0 Calponin family repeat HlyIII PF03006.15 KII73424.1 - 2.4e-53 180.8 32.3 2.9e-53 180.5 22.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.6 KII73424.1 - 0.13 12.1 4.1 2 8.3 2.8 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF962) DDE_3 PF13358.1 KII73426.1 - 3.4e-10 39.8 0.1 1.1e-09 38.2 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII73427.1 - 3.9e-13 48.9 0.7 7.2e-13 48.1 0.5 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 KII73427.1 - 0.00068 19.0 0.1 0.0016 17.8 0.0 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.1 KII73427.1 - 0.0017 17.9 0.1 0.36 10.5 0.0 2.2 2 0 0 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.1 KII73427.1 - 0.0028 17.6 0.2 1.7 8.7 0.0 2.2 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_IclR PF09339.5 KII73427.1 - 0.048 13.2 0.0 0.079 12.5 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain Zn_Tnp_IS1595 PF12760.2 KII73428.1 - 0.00027 20.6 4.1 0.00027 20.6 2.8 1.8 2 0 0 2 2 2 1 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.11 KII73428.1 - 0.013 15.1 0.9 0.013 15.1 0.6 2.8 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.13 KII73428.1 - 0.11 12.1 13.4 0.17 11.5 0.2 3.3 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) Opy2 PF09463.5 KII73428.1 - 0.3 11.1 0.5 0.3 11.1 0.4 2.6 3 0 0 3 3 3 0 Opy2 protein zinc_ribbon_5 PF13719.1 KII73428.1 - 0.52 9.9 7.8 20 4.8 0.0 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-trcl PF13451.1 KII73428.1 - 0.74 9.4 9.1 0.24 11.0 2.8 2.5 2 1 1 3 3 3 0 Probable zinc-binding domain zinc_ribbon_4 PF13717.1 KII73428.1 - 2.1 8.1 8.9 25 4.6 0.3 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Ribosomal_S27e PF01667.12 KII73428.1 - 2.5 7.6 7.1 23 4.6 2.4 3.0 2 1 0 2 2 2 0 Ribosomal protein S27 Zn_Tnp_IS1 PF03811.8 KII73428.1 - 6.1 6.4 8.2 4.1 6.9 0.1 3.1 3 0 0 3 3 3 0 InsA N-terminal domain Prosystemin PF07376.6 KII73429.1 - 0.046 13.0 1.4 0.052 12.9 0.9 1.0 1 0 0 1 1 1 0 Prosystemin Rtt106 PF08512.7 KII73429.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.4 2 0 0 2 2 2 0 Histone chaperone Rttp106-like UN_NPL4 PF11543.3 KII73430.1 - 0.099 12.9 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 ERO1 PF04137.10 KII73432.1 - 6.7e-96 321.4 2.9 1e-95 320.8 2.0 1.2 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) IF4E PF01652.13 KII73433.1 - 2.9e-27 95.2 1.2 3.4e-27 94.9 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF1548 PF07579.6 KII73436.1 - 0.0038 17.3 1.3 0.0038 17.3 0.9 1.9 2 1 0 2 2 2 1 Domain of Unknown Function (DUF1548) MFS_1 PF07690.11 KII73439.1 - 1.8e-23 82.8 0.1 2.1e-23 82.6 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 KII73439.1 - 0.0017 16.8 3.5 0.2 10.0 1.2 2.0 1 1 1 2 2 2 2 MFS/sugar transport protein CagY_I PF14585.1 KII73439.1 - 0.2 11.6 1.0 0.31 11.0 0.7 1.2 1 0 0 1 1 1 0 CagY type 1 repeat CENP-U PF13097.1 KII73443.1 - 0.25 11.2 3.2 0.52 10.2 2.2 1.5 1 1 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit LacI PF00356.16 KII73444.1 - 0.014 14.9 0.5 0.3 10.7 0.1 2.4 2 1 0 2 2 2 0 Bacterial regulatory proteins, lacI family HTH_Tnp_Tc3_2 PF01498.13 KII73444.1 - 0.043 13.8 0.1 0.074 13.1 0.1 1.5 1 0 0 1 1 1 0 Transposase STAT_alpha PF01017.15 KII73444.1 - 0.095 12.4 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 STAT protein, all-alpha domain Phage_int_SAM_2 PF12834.2 KII73444.1 - 0.19 12.1 1.0 0.24 11.7 0.7 1.3 1 1 0 1 1 1 0 Phage integrase, N-terminal RTA1 PF04479.8 KII73447.1 - 0.047 13.1 1.6 0.057 12.9 1.1 1.2 1 0 0 1 1 1 0 RTA1 like protein Vma12 PF11712.3 KII73448.1 - 0.12 12.1 2.8 0.37 10.4 1.9 2.0 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DDE_3 PF13358.1 KII73449.1 - 2e-06 27.5 0.0 8.6e-06 25.5 0.0 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease 5_nucleotid PF05761.9 KII73451.1 - 2e-79 267.2 2.4 2.8e-79 266.7 1.7 1.2 1 0 0 1 1 1 1 5' nucleotidase family DUF3329 PF11808.3 KII73451.1 - 0.043 13.9 0.1 0.096 12.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3329) PRMT5 PF05185.11 KII73452.1 - 2.5e-16 59.6 0.1 3.5e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PrmA PF06325.8 KII73452.1 - 7.5e-09 35.1 0.1 1.3e-08 34.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 KII73452.1 - 4.3e-08 33.7 0.0 1.8e-07 31.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.6 KII73452.1 - 3.2e-07 29.3 0.0 4.9e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_26 PF13659.1 KII73452.1 - 7e-07 29.2 0.0 1.5e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII73452.1 - 2.5e-06 27.1 0.2 8.7e-06 25.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KII73452.1 - 0.00011 21.5 0.0 0.00023 20.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain GidB PF02527.10 KII73452.1 - 0.00068 18.8 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G CMAS PF02353.15 KII73452.1 - 0.00074 18.6 0.0 0.0012 17.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 KII73452.1 - 0.0019 17.9 0.0 0.0032 17.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KII73452.1 - 0.0045 17.4 0.0 0.072 13.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KII73452.1 - 0.0057 17.1 0.1 0.17 12.3 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Rsm22 PF09243.5 KII73452.1 - 0.018 14.0 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_16 PF10294.4 KII73452.1 - 0.034 13.6 0.0 0.058 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Cons_hypoth95 PF03602.10 KII73452.1 - 0.059 12.7 0.0 0.099 12.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PCI PF01399.22 KII73454.1 - 9.7e-20 70.8 0.9 8.4e-19 67.8 0.2 2.5 2 0 0 2 2 2 1 PCI domain Rpn3_C PF08375.6 KII73454.1 - 0.01 16.2 0.5 0.021 15.1 0.3 1.5 1 0 0 1 1 1 0 Proteasome regulatory subunit C-terminal PCI_Csn8 PF10075.4 KII73454.1 - 0.066 12.9 0.3 0.4 10.4 0.0 2.4 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 Desulfoferrod_N PF06397.7 KII73455.1 - 0.3 10.5 3.4 5.4 6.4 0.4 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Glycos_transf_1 PF00534.15 KII73456.1 - 2.5e-21 75.8 0.0 3.9e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KII73456.1 - 2.4e-07 30.9 0.0 3.8e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KII73456.1 - 0.00011 22.4 0.0 0.00021 21.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 TroA PF01297.12 KII73458.1 - 0.014 14.6 2.8 0.017 14.3 1.2 1.6 1 1 0 1 1 1 0 Periplasmic solute binding protein family Herpes_UL31 PF02718.9 KII73459.1 - 0.0018 17.0 0.0 0.0024 16.6 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus UL31-like protein WD40 PF00400.27 KII73460.1 - 0.0042 16.9 0.1 0.014 15.2 0.0 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat BBS2_N PF14781.1 KII73460.1 - 0.01 15.4 0.0 0.013 15.1 0.0 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal Aa_trans PF01490.13 KII73462.1 - 2.6e-45 154.6 53.2 3e-45 154.4 36.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KII73462.1 - 6.2e-08 31.8 45.9 1e-07 31.1 31.8 1.3 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family DUF962 PF06127.6 KII73462.1 - 0.00084 19.1 0.2 0.1 12.4 0.0 3.8 1 1 1 2 2 2 1 Protein of unknown function (DUF962) Ldl_recept_a PF00057.13 KII73463.1 - 3e-08 33.4 10.0 3e-08 33.4 6.9 2.7 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII73464.1 - 0.68 9.9 7.7 3.6 7.8 0.1 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat DDE_Tnp_IS1595 PF12762.2 KII73466.1 - 1.1e-19 70.7 0.3 1.8e-19 70.0 0.2 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS240 PF13610.1 KII73466.1 - 0.0027 17.6 0.1 0.0037 17.2 0.0 1.1 1 0 0 1 1 1 1 DDE domain Peroxidase_2 PF01328.12 KII73466.1 - 0.01 14.5 0.1 0.013 14.1 0.1 1.1 1 0 0 1 1 1 0 Peroxidase, family 2 UPF0160 PF03690.8 KII73466.1 - 0.071 12.5 0.1 0.079 12.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) Phage_int_SAM_3 PF14659.1 KII73466.1 - 0.13 12.5 0.0 9.5 6.5 0.0 2.6 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Kelch_6 PF13964.1 KII73467.1 - 6.6e-24 83.0 22.2 1.3e-06 28.3 0.1 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 KII73467.1 - 4.2e-21 74.5 11.2 0.00063 19.8 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.1 KII73467.1 - 4.8e-16 58.2 20.9 0.001 18.8 0.1 6.7 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73467.1 - 2.6e-15 55.6 23.4 0.0045 16.4 0.3 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.1 KII73467.1 - 2e-11 43.5 19.2 0.0022 17.9 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KII73467.1 - 3.2e-08 33.0 18.2 0.15 11.8 0.2 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 KII73468.1 - 4.5e-05 23.4 1.9 0.4 10.9 0.0 3.2 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.1 KII73468.1 - 0.00028 20.5 4.0 0.1 12.3 0.1 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII73468.1 - 0.00063 19.8 1.0 0.72 10.0 0.0 3.0 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73468.1 - 0.00071 19.0 0.8 0.66 9.5 0.0 2.6 2 1 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII73469.1 - 2e-12 46.4 0.9 5.1e-10 38.7 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 KII73469.1 - 9.2e-12 44.6 1.2 2e-08 34.0 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 KII73469.1 - 3e-09 36.8 1.0 3.7e-08 33.3 0.1 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KII73469.1 - 1.2e-08 34.5 1.6 3.8e-07 29.7 0.1 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.10 KII73469.1 - 2.5e-06 27.0 0.4 0.0025 17.5 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.1 KII73469.1 - 3.6e-05 23.6 0.7 0.25 11.3 0.0 2.3 2 0 0 2 2 2 2 Kelch motif AIRS_C PF02769.17 KII73470.1 - 4e-22 78.8 0.0 4.8e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain Kelch_3 PF13415.1 KII73472.1 - 1.6e-06 28.0 10.4 0.025 14.7 0.0 5.8 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_6 PF13964.1 KII73472.1 - 1.9e-06 27.7 10.3 0.011 15.8 0.1 6.0 6 0 0 6 6 6 1 Kelch motif Kelch_2 PF07646.10 KII73472.1 - 0.0004 20.0 5.1 1.5 8.6 0.0 4.9 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.1 KII73472.1 - 0.00086 19.0 4.0 1.3 8.8 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KII73472.1 - 0.0037 17.1 3.5 0.75 9.8 0.0 3.6 3 0 0 3 3 3 2 Kelch motif DUF1294 PF06961.8 KII73475.1 - 0.037 13.9 0.2 0.21 11.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1294) Rotamase PF00639.16 KII73477.1 - 5.3e-20 71.9 0.1 2e-19 70.1 0.1 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KII73477.1 - 1.1e-19 70.8 0.1 2.5e-19 69.6 0.1 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KII73477.1 - 9.7e-07 29.4 0.0 1.7e-06 28.6 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain BRCT PF00533.21 KII73478.1 - 1.3e-18 66.9 0.1 1.1e-16 60.6 0.0 3.3 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.24 KII73478.1 - 1.3e-13 51.2 0.1 7.8e-13 48.7 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KII73478.1 - 7.1e-09 36.5 0.1 4.2e-08 34.0 0.0 2.4 2 1 0 2 2 1 1 AAA domain PTCB-BRCT PF12738.2 KII73478.1 - 1.5e-07 31.1 0.0 5.5e-07 29.3 0.0 2.0 2 0 0 2 2 1 1 twin BRCT domain DNA_pol3_delta PF06144.8 KII73478.1 - 5.3e-07 29.3 0.6 5.3e-07 29.3 0.4 2.3 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 KII73478.1 - 1.8e-06 27.8 0.1 5.4e-06 26.3 0.0 2.1 2 1 0 2 2 1 1 AAA domain Rad17 PF03215.10 KII73478.1 - 4e-06 25.7 1.4 0.0009 18.0 0.2 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein RNA_helicase PF00910.17 KII73478.1 - 5.5e-06 26.5 0.2 2.1e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.1 KII73478.1 - 3.8e-05 23.8 3.6 0.00062 19.9 0.4 3.3 3 1 0 3 3 3 1 AAA domain RuvB_N PF05496.7 KII73478.1 - 6.5e-05 22.0 0.0 0.0095 15.0 0.0 3.0 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 KII73478.1 - 0.00014 22.1 0.1 0.00058 20.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KII73478.1 - 0.00058 19.8 0.2 0.022 14.7 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.7 KII73478.1 - 0.0022 17.0 0.0 0.0051 15.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Sigma54_activ_2 PF14532.1 KII73478.1 - 0.0035 17.3 0.1 0.057 13.4 0.0 2.8 3 0 0 3 3 3 1 Sigma-54 interaction domain NTPase_1 PF03266.10 KII73478.1 - 0.0061 16.2 1.3 0.14 11.8 0.0 2.5 1 1 0 2 2 2 1 NTPase AAA_5 PF07728.9 KII73478.1 - 0.0095 15.6 0.0 0.032 13.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 KII73478.1 - 0.022 14.6 0.0 0.057 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 KII73478.1 - 0.064 12.7 0.2 0.68 9.4 0.1 2.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_11 PF13086.1 KII73478.1 - 7.1 6.1 9.4 0.29 10.6 1.4 2.4 2 1 0 2 2 2 0 AAA domain RFC1 PF08519.7 KII73479.1 - 5.6e-42 143.1 0.1 7.6e-42 142.6 0.1 1.2 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain Steroid_dh PF02544.11 KII73480.1 - 2.7e-23 82.3 4.4 2.7e-23 82.3 3.0 1.7 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.8 KII73480.1 - 0.0049 16.9 4.6 0.45 10.6 0.7 2.5 2 0 0 2 2 2 2 Phospholipid methyltransferase DUF1295 PF06966.7 KII73480.1 - 0.038 13.2 0.4 0.066 12.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) FixO PF02433.10 KII73481.1 - 0.051 12.9 0.6 0.12 11.6 0.4 1.6 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO NT-C2 PF10358.4 KII73482.1 - 0.045 13.2 0.6 0.053 13.0 0.4 1.2 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins BRE1 PF08647.6 KII73482.1 - 0.35 10.8 4.0 0.28 11.1 0.6 1.8 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF2170 PF09938.4 KII73485.1 - 0.14 11.4 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2170) rve PF00665.21 KII73487.1 - 9.1e-29 100.0 0.0 1.5e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII73487.1 - 0.00025 21.0 0.3 0.001 19.0 0.0 1.9 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.1 KII73487.1 - 0.0037 16.7 0.0 0.0089 15.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF4522 PF15022.1 KII73487.1 - 0.059 13.0 0.1 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) DUF2018 PF09442.5 KII73492.1 - 0.66 10.5 4.4 0.48 11.0 1.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF2018) DUF4577 PF15145.1 KII73493.1 - 0.15 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) Kunitz_BPTI PF00014.18 KII73494.1 - 7.6e-06 26.0 9.4 0.031 14.4 7.1 2.3 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Cation_ATPase_C PF00689.16 KII73495.1 - 1.4e-38 132.2 1.2 1.9e-38 131.7 0.8 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KII73495.1 - 3.3e-27 96.3 0.1 5.4e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KII73495.1 - 1.3e-10 41.7 0.0 3.1e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KII73495.1 - 1.9e-06 27.6 0.9 0.0001 22.0 0.3 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 KII73496.1 - 3.3e-61 206.2 1.1 3.9e-60 202.7 1.8 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 KII73496.1 - 3.5e-05 23.1 0.0 0.00097 18.5 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.21 KII73496.1 - 0.00042 20.7 0.0 0.00089 19.7 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KII73496.1 - 0.00083 19.2 0.0 0.0027 17.6 0.0 1.9 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit 7TMR-DISM_7TM PF07695.6 KII73496.1 - 0.0041 16.8 4.8 0.096 12.3 0.0 2.2 2 0 0 2 2 2 1 7TM diverse intracellular signalling HAD PF12710.2 KII73496.1 - 0.0077 16.4 0.1 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UbiA PF01040.13 KII73496.1 - 0.034 13.3 2.6 0.28 10.3 0.1 2.1 2 0 0 2 2 2 0 UbiA prenyltransferase family Tetraspannin PF00335.15 KII73496.1 - 0.051 12.8 0.3 0.051 12.8 0.2 2.7 2 1 1 3 3 3 0 Tetraspanin family DUF4131 PF13567.1 KII73496.1 - 0.052 12.9 1.8 0.18 11.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4064 PF13273.1 KII73496.1 - 0.071 13.2 13.6 2 8.5 0.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) DUF1516 PF07457.6 KII73496.1 - 0.17 11.9 5.0 2.4 8.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) CAAD PF14159.1 KII73496.1 - 0.3 10.7 5.9 0.79 9.4 4.1 1.7 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DDE_3 PF13358.1 KII73497.1 - 6e-27 94.1 0.0 1.2e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.1 KII73497.1 - 4.6e-06 26.0 1.0 0.00011 21.6 0.1 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.1 KII73497.1 - 0.00047 19.4 0.6 0.98 8.8 0.0 3.4 4 0 0 4 4 4 2 Winged helix-turn-helix DNA-binding HTH_Tnp_IS630 PF01710.11 KII73497.1 - 0.0086 15.7 0.6 0.018 14.6 0.4 1.4 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.1 KII73497.1 - 0.023 14.2 0.0 0.059 12.9 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix HTH_28 PF13518.1 KII73497.1 - 0.026 14.5 0.9 0.36 10.8 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Bot1p PF12298.3 KII73497.1 - 0.027 14.4 0.4 0.053 13.4 0.3 1.5 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein TrmB PF01978.14 KII73497.1 - 0.061 13.0 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sbi-IV PF11621.3 KII73497.1 - 0.12 12.5 0.1 0.3 11.2 0.0 1.7 2 0 0 2 2 2 0 C3 binding domain 4 of IgG-bind protein SBI MULE PF10551.4 KII73499.1 - 0.095 12.8 0.0 0.21 11.8 0.0 1.8 1 1 0 1 1 1 0 MULE transposase domain PAX PF00292.13 KII73500.1 - 0.077 12.7 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 'Paired box' domain Pro_isomerase PF00160.16 KII73503.1 - 8e-48 162.5 0.0 1e-47 162.2 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DDE_3 PF13358.1 KII73505.1 - 0.00012 21.8 1.3 0.00022 21.0 0.9 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease PilS PF08805.6 KII73506.1 - 0.00059 19.3 0.3 0.00088 18.7 0.2 1.4 1 0 0 1 1 1 1 PilS N terminal DUF2996 PF11210.3 KII73506.1 - 0.081 13.1 0.9 0.87 9.8 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2996) Pribosyltran PF00156.22 KII73507.1 - 1.1e-24 86.5 0.0 1.4e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KII73507.1 - 3.8e-05 22.9 0.0 5.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.1 KII73507.1 - 0.097 11.9 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase SAD_SRA PF02182.12 KII73508.1 - 0.02 14.1 0.1 0.023 14.0 0.1 1.0 1 0 0 1 1 1 0 SAD/SRA domain Uds1 PF15456.1 KII73508.1 - 0.073 13.0 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Up-regulated During Septation SYF2 PF08231.7 KII73509.1 - 1.3e-32 113.0 5.3 1.3e-32 113.0 3.7 2.1 1 1 1 2 2 2 1 SYF2 splicing factor SpoIIIAH PF12685.2 KII73509.1 - 0.032 13.7 7.7 0.057 12.9 5.4 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF365 PF04033.7 KII73509.1 - 3.1 7.8 6.5 0.35 10.8 0.8 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF365) MoaC PF01967.16 KII73510.1 - 8e-47 158.3 0.1 9.8e-47 158.0 0.1 1.1 1 0 0 1 1 1 1 MoaC family Reo_sigma1 PF01664.11 KII73510.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Reovirus viral attachment protein sigma 1 Glycos_transf_2 PF00535.21 KII73512.1 - 0.00012 21.7 0.4 0.00023 20.8 0.3 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 GATA PF00320.22 KII73513.1 - 5.6e-12 44.7 2.1 5.6e-12 44.7 1.4 3.0 4 0 0 4 4 4 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 KII73513.1 - 0.00032 19.9 5.2 0.059 12.7 1.3 2.7 2 1 0 2 2 2 2 TFIIB zinc-binding zf-RING_3 PF14369.1 KII73513.1 - 0.00054 19.9 4.5 0.035 14.1 2.5 3.3 2 1 1 3 3 3 1 zinc-finger zf-TFIIB PF13453.1 KII73513.1 - 0.0014 17.7 0.1 0.0043 16.2 0.1 1.9 1 0 0 1 1 1 1 Transcription factor zinc-finger zf-FPG_IleRS PF06827.9 KII73513.1 - 0.0045 16.5 0.4 0.012 15.2 0.3 1.8 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS COX5B PF01215.14 KII73513.1 - 0.01 15.5 0.7 0.98 9.0 0.0 3.1 3 0 0 3 3 3 0 Cytochrome c oxidase subunit Vb DUF4428 PF14471.1 KII73513.1 - 0.037 13.7 4.4 4.6 7.0 0.0 4.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4428) DUF1610 PF07754.6 KII73513.1 - 0.046 13.8 0.6 0.046 13.8 0.4 2.3 3 0 0 3 3 2 0 Domain of unknown function (DUF1610) IBR PF01485.16 KII73513.1 - 0.13 12.1 1.1 0.34 10.8 0.1 2.1 2 0 0 2 2 2 0 IBR domain OrfB_Zn_ribbon PF07282.6 KII73513.1 - 0.16 11.6 1.3 0.64 9.7 0.1 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain RRN7 PF11781.3 KII73513.1 - 0.24 10.9 1.3 33 4.0 0.0 3.2 3 0 0 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 Zn-ribbon_8 PF09723.5 KII73513.1 - 0.35 10.8 2.7 14 5.7 1.3 3.1 2 1 1 3 3 3 0 Zinc ribbon domain PhnA_Zn_Ribbon PF08274.7 KII73513.1 - 0.4 10.4 7.5 2.1 8.2 2.8 2.9 2 1 1 3 3 3 0 PhnA Zinc-Ribbon DUF1272 PF06906.6 KII73513.1 - 0.45 10.4 2.3 2 8.3 1.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) DZR PF12773.2 KII73513.1 - 0.5 10.2 4.7 14 5.5 3.5 2.6 1 1 0 1 1 1 0 Double zinc ribbon NOB1_Zn_bind PF08772.6 KII73513.1 - 1.4 8.8 8.0 4.7 7.0 0.7 3.0 2 1 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like A2L_zn_ribbon PF08792.5 KII73513.1 - 1.5 8.4 5.3 32 4.1 0.0 3.4 3 0 0 3 3 3 0 A2L zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 KII73513.1 - 1.5 8.6 7.4 5.3 6.9 0.2 3.3 2 1 1 3 3 3 0 Transposase zinc-ribbon domain TRAPPC9-Trs120 PF08626.6 KII73515.1 - 9.1e-19 66.3 3.1 1.9e-08 32.1 2.4 2.8 2 1 0 2 2 2 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.2 KII73515.1 - 0.00012 20.8 0.2 0.00021 20.0 0.1 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_12 PF13424.1 KII73515.1 - 0.0056 16.5 1.2 0.023 14.6 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Kdo PF06293.9 KII73516.1 - 2.2e-06 26.9 0.0 2.9e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 KII73516.1 - 1.9e-05 23.9 0.0 3.1e-05 23.2 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 KII73516.1 - 8.4e-05 22.4 0.0 9.9e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 KII73516.1 - 0.00043 19.5 0.0 0.00047 19.4 0.0 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.17 KII73516.1 - 0.0086 15.4 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.12 KII73516.1 - 0.015 14.4 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase TBP PF00352.16 KII73516.1 - 0.083 12.2 0.0 0.64 9.4 0.0 2.0 2 0 0 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) CPSF_A PF03178.10 KII73517.1 - 1.7e-36 125.9 4.5 6e-35 120.8 2.4 2.5 2 0 0 2 2 2 2 CPSF A subunit region YaeQ PF07152.7 KII73517.1 - 0.082 12.2 0.0 0.2 10.9 0.0 1.6 1 0 0 1 1 1 0 YaeQ protein HSP20 PF00011.16 KII73518.1 - 2.3e-23 82.0 5.1 4.1e-15 55.4 0.2 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family SPOB_ab PF14682.1 KII73522.1 - 0.07 12.9 0.1 0.085 12.6 0.1 1.2 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal M60-like PF13402.1 KII73523.1 - 0.0012 17.8 2.9 0.0016 17.4 2.0 1.1 1 0 0 1 1 1 1 Peptidase M60-like family DUF3165 PF11364.3 KII73523.1 - 0.25 11.4 3.4 0.22 11.6 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3165) GreA_GreB PF01272.14 KII73525.1 - 0.085 12.5 0.5 0.17 11.6 0.0 1.7 2 0 0 2 2 2 0 Transcription elongation factor, GreA/GreB, C-term Presenilin PF01080.12 KII73525.1 - 2.7 6.6 4.6 3.6 6.3 3.2 1.1 1 0 0 1 1 1 0 Presenilin Hom_end_hint PF05203.11 KII73525.1 - 4.9 6.8 9.7 5.9 6.5 6.7 1.1 1 0 0 1 1 1 0 Hom_end-associated Hint CDC45 PF02724.9 KII73525.1 - 5.3 4.9 12.2 7 4.5 8.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 KII73525.1 - 8.9 5.6 20.6 5.9 6.1 13.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1510) TRAP_alpha PF03896.11 KII73527.1 - 1.3e-27 96.5 0.2 1.5e-27 96.3 0.1 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Pox_A14 PF05767.7 KII73527.1 - 0.011 15.6 0.6 0.021 14.7 0.1 1.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 CstA PF02554.9 KII73527.1 - 0.015 14.0 0.0 0.022 13.4 0.0 1.2 1 0 0 1 1 1 0 Carbon starvation protein CstA ARF7EP_C PF14949.1 KII73528.1 - 0.11 12.8 0.8 0.16 12.4 0.1 1.5 2 0 0 2 2 2 0 ARF7 effector protein C-terminus CSD PF00313.17 KII73529.1 - 4.2e-08 32.8 0.0 6.7e-08 32.2 0.0 1.4 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain HTH_Tnp_Tc5 PF03221.11 KII73530.1 - 4e-08 32.9 0.1 9.1e-08 31.8 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain ENTH PF01417.15 KII73531.1 - 2.5e-29 101.7 0.1 3.7e-29 101.1 0.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 KII73531.1 - 1.3e-07 30.6 0.1 1.8e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 ANTH domain UIM PF02809.15 KII73531.1 - 0.11 12.0 3.1 0.25 11.0 1.3 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF1987 PF09345.5 KII73533.1 - 0.12 12.1 0.5 0.47 10.2 0.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1987) Gam PF06064.6 KII73534.1 - 0.078 13.0 0.2 3.2 7.8 0.0 2.1 2 0 0 2 2 2 0 Host-nuclease inhibitor protein Gam Oxidored_q6 PF01058.17 KII73535.1 - 6.1e-22 77.6 0.1 1e-21 76.9 0.1 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit DDE_3 PF13358.1 KII73536.1 - 0.11 12.2 0.0 0.88 9.3 0.0 1.8 1 1 1 2 2 2 0 DDE superfamily endonuclease RE_HpaII PF09561.5 KII73537.1 - 0.094 11.8 3.5 0.12 11.5 2.4 1.1 1 0 0 1 1 1 0 HpaII restriction endonuclease Galactosyl_T PF01762.16 KII73538.1 - 3.9e-08 33.1 0.1 4.2e-08 33.0 0.1 1.0 1 0 0 1 1 1 1 Galactosyltransferase DUF2012 PF09430.5 KII73538.1 - 0.11 12.2 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Ribosomal_L18p PF00861.17 KII73539.1 - 1e-06 28.9 0.0 1.6e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal L18p/L5e family DUF1981 PF09324.5 KII73541.1 - 0.067 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) DDE_Tnp_IS1595 PF12762.2 KII73542.1 - 5.8e-12 45.6 0.1 3e-11 43.3 0.1 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII73542.1 - 0.2 11.4 2.2 0.37 10.5 0.6 2.1 1 1 1 2 2 2 0 DDE superfamily endonuclease MASE1 PF05231.9 KII73543.1 - 0.071 12.1 3.3 0.095 11.6 2.3 1.2 1 0 0 1 1 1 0 MASE1 Herpes_DNAp_acc PF04929.7 KII73543.1 - 1.3 7.9 4.2 1.6 7.5 2.9 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF2427 PF10348.4 KII73543.1 - 2.4 7.7 8.0 0.48 10.0 0.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) HTH_Tnp_Tc5 PF03221.11 KII73547.1 - 2.1e-14 53.0 0.2 3.5e-14 52.3 0.2 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 KII73547.1 - 0.00017 20.9 0.1 0.0004 19.7 0.1 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_3 PF01381.17 KII73547.1 - 0.01 15.6 0.7 0.05 13.4 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix Plasmid_stabil PF05016.9 KII73547.1 - 0.012 16.0 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 Plasmid stabilisation system protein HTH_IclR PF09339.5 KII73547.1 - 0.028 13.9 0.1 0.08 12.5 0.0 1.7 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_23 PF13384.1 KII73547.1 - 0.047 13.3 1.5 0.23 11.1 0.0 2.6 3 0 0 3 3 3 0 Homeodomain-like domain HTH_38 PF13936.1 KII73547.1 - 0.075 12.5 0.2 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain Prenyltransf PF01255.14 KII73548.1 - 0.061 12.4 0.0 0.067 12.2 0.0 1.1 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase HTH_IclR PF09339.5 KII73548.1 - 0.068 12.7 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain DNA_pol3_a_NI PF14480.1 KII73551.1 - 0.057 13.0 0.6 1.9 8.1 0.0 3.2 3 1 0 3 3 3 0 DNA polymerase III polC-type N-terminus I Clathrin_bdg PF15045.1 KII73552.1 - 0.027 13.9 0.3 0.045 13.2 0.2 1.6 1 1 0 1 1 1 0 Clathrin-binding box of Aftiphilin, vesicle trafficking CBS PF00571.23 KII73553.1 - 1.7e-07 30.8 0.6 0.0029 17.3 0.1 2.5 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.24 KII73553.1 - 0.00047 19.9 0.0 0.0014 18.3 0.0 1.8 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain DUF4062 PF13271.1 KII73553.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) DDE_3 PF13358.1 KII73555.1 - 9.6e-06 25.4 0.2 3e-05 23.8 0.1 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease Ribosomal_S17 PF00366.15 KII73559.1 - 0.057 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S17 PAN_4 PF14295.1 KII73560.1 - 0.33 10.7 1.4 2.1 8.1 0.0 2.4 1 1 1 2 2 2 0 PAN domain DUF445 PF04286.7 KII73562.1 - 0.017 14.6 5.6 0.02 14.4 3.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Nbl1_Borealin_N PF10444.4 KII73562.1 - 1.3 8.3 9.5 0.14 11.5 0.4 2.5 2 1 0 2 2 2 0 Nbl1 / Borealin N terminal Spore_II_R PF09551.5 KII73562.1 - 7.2 6.6 7.3 8.5 6.4 0.3 2.1 1 1 1 2 2 2 0 Stage II sporulation protein R (spore_II_R) SNAP PF14938.1 KII73563.1 - 3e-09 36.4 0.1 4.2e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII73563.1 - 0.002 17.9 3.0 0.1 12.5 0.3 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KII73563.1 - 0.011 15.3 0.8 0.62 9.7 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 KII73563.1 - 0.11 12.4 1.1 0.31 10.9 0.3 2.1 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 KII73563.1 - 0.38 10.6 1.8 9.3 6.3 0.2 3.1 1 1 1 2 2 2 0 Tetratricopeptide repeat NSF PF02071.15 KII73563.1 - 5.5 8.0 8.6 20 6.3 1.0 3.8 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.1 KII73563.1 - 10 6.2 7.7 22 5.1 0.3 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat ABC_tran_2 PF12848.2 KII73564.1 - 3.2 7.6 9.7 2.1 8.2 5.2 1.9 1 1 1 2 2 2 0 ABC transporter GATA PF00320.22 KII73565.1 - 1.6e-12 46.5 1.2 3.3e-12 45.5 0.8 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 KII73565.1 - 0.0087 15.3 0.9 0.0087 15.3 0.6 2.3 2 0 0 2 2 2 1 TFIIB zinc-binding zf-ribbon_3 PF13248.1 KII73565.1 - 0.7 9.1 3.2 1.7 7.9 2.2 1.6 1 1 0 1 1 1 0 zinc-ribbon domain Ion_trans PF00520.26 KII73566.1 - 0.051 12.8 0.6 0.071 12.3 0.4 1.2 1 0 0 1 1 1 0 Ion transport protein UPF0197 PF05251.7 KII73567.1 - 0.43 10.9 5.2 3.1 8.1 3.6 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0197) DUF1179 PF06678.6 KII73567.1 - 1.4 9.2 3.1 0.95 9.8 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) MSA-2c PF12238.3 KII73569.1 - 0.016 14.9 0.2 0.026 14.1 0.1 1.4 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF1900 PF08954.6 KII73571.1 - 8.8e-35 119.1 0.0 2e-34 118.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 KII73571.1 - 1.3e-13 50.3 0.1 4.3e-13 48.7 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1899) WD40 PF00400.27 KII73571.1 - 2.5e-05 23.9 0.2 0.007 16.2 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF4221 PF13970.1 KII73571.1 - 0.0023 17.2 0.1 0.0082 15.4 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4221) PQQ PF01011.16 KII73571.1 - 0.034 13.6 0.0 1.2 8.8 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat BCS1_N PF08740.6 KII73573.1 - 0.034 13.7 0.2 0.034 13.7 0.1 1.1 1 0 0 1 1 1 0 BCS1 N terminal PRANC PF09372.5 KII73573.1 - 0.11 12.4 3.3 0.073 13.0 0.4 1.8 1 1 1 2 2 2 0 PRANC domain FimP PF09766.4 KII73574.1 - 1.8e-12 47.0 0.9 1.9e-10 40.3 0.3 2.3 2 0 0 2 2 2 2 Fms-interacting protein Nyv1_N PF09426.5 KII73575.1 - 0.041 13.4 0.0 0.058 12.9 0.0 1.3 1 1 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal 7tm_3 PF00003.17 KII73576.1 - 0.00055 19.3 0.5 0.00084 18.7 0.4 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR SCAMP PF04144.8 KII73576.1 - 0.0083 16.0 12.8 0.011 15.6 8.8 1.2 1 0 0 1 1 1 1 SCAMP family Mito_morph_reg PF14972.1 KII73577.1 - 9.3e-15 54.4 0.1 1.1e-14 54.1 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial morphogenesis regulator HTH_Tnp_Tc3_2 PF01498.13 KII73578.1 - 0.0017 18.3 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.1 KII73578.1 - 0.15 12.2 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn helix DUF1647 PF07801.6 KII73579.1 - 0.12 11.8 2.7 0.13 11.7 0.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1647) DDE_3 PF13358.1 KII73580.1 - 5.5e-19 68.3 0.0 6.5e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Kunitz_BPTI PF00014.18 KII73585.1 - 4.2e-07 30.0 10.2 1.9e-06 27.9 4.8 2.4 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Kunitz_BPTI PF00014.18 KII73587.1 - 0.00016 21.7 8.5 0.00016 21.7 5.9 2.7 2 1 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF957 PF06117.6 KII73587.1 - 0.39 10.2 1.5 2.8 7.5 0.1 2.1 1 1 1 2 2 2 0 Enterobacterial protein of unknown function (DUF957) Kunitz_BPTI PF00014.18 KII73588.1 - 0.00032 20.8 16.4 0.0011 19.1 5.2 2.5 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Furin-like PF00757.15 KII73589.1 - 0.033 13.8 2.0 0.14 11.7 0.3 2.0 2 0 0 2 2 2 0 Furin-like cysteine rich region Kunitz_BPTI PF00014.18 KII73589.1 - 0.11 12.6 15.8 1.3 9.3 4.0 2.5 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF4005 PF13178.1 KII73590.1 - 0.18 12.0 4.6 0.32 11.2 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4005) Toxin_2 PF00451.14 KII73591.1 - 0.047 13.7 2.8 0.11 12.6 0.2 2.3 2 0 0 2 2 2 0 Scorpion short toxin, BmKK2 Kunitz_BPTI PF00014.18 KII73591.1 - 0.4 10.9 7.4 4.6 7.5 1.2 2.5 2 0 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF1472 PF07339.7 KII73592.1 - 0.091 13.0 0.3 0.14 12.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1472) Filamin PF00630.14 KII73596.1 - 0.12 12.9 0.0 0.14 12.7 0.0 1.3 1 1 0 1 1 1 0 Filamin/ABP280 repeat PXPV PF12778.2 KII73597.1 - 0.37 10.5 3.6 0.66 9.7 2.5 1.3 1 0 0 1 1 1 0 PXPV repeat (3 copies) PRELI PF04707.9 KII73598.1 - 3.2e-31 108.0 0.3 6e-31 107.1 0.2 1.5 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.15 KII73598.1 - 2.2e-21 76.0 0.1 1.3e-20 73.5 0.1 2.1 1 1 0 1 1 1 1 CRAL/TRIO domain DUF1672 PF07901.6 KII73599.1 - 0.0041 16.1 0.6 0.0052 15.8 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1672) S10_plectin PF03501.10 KII73599.1 - 0.019 14.8 0.4 0.067 13.0 0.1 1.9 2 0 0 2 2 2 0 Plectin/S10 domain Antigen_Bd37 PF11641.3 KII73599.1 - 0.061 12.5 0.4 0.075 12.3 0.3 1.1 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein Methyltransf_15 PF09445.5 KII73600.1 - 1e-19 70.7 0.0 1.1e-19 70.5 0.0 1.0 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Hexapep PF00132.19 KII73601.1 - 4.4e-12 44.9 9.9 9.9e-07 27.9 0.6 4.3 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KII73601.1 - 0.0068 15.9 2.2 0.0068 15.9 1.5 3.1 2 1 1 3 3 3 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.7 KII73601.1 - 0.1 11.1 0.0 0.13 10.7 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase PK PF00224.16 KII73602.1 - 5.6e-83 278.4 2.3 7e-83 278.1 1.6 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KII73602.1 - 2.1e-27 95.0 0.2 7.2e-27 93.2 0.1 2.0 1 1 1 2 2 2 1 Pyruvate kinase, alpha/beta domain BT1 PF03092.11 KII73603.1 - 0.081 11.6 0.0 0.092 11.4 0.0 1.0 1 0 0 1 1 1 0 BT1 family DUF4448 PF14610.1 KII73606.1 - 0.0015 18.0 0.2 0.0042 16.6 0.1 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF4448) AKAP7_NLS PF10469.4 KII73606.1 - 0.021 14.5 0.2 0.03 14.0 0.1 1.2 1 0 0 1 1 1 0 AKAP7 2'5' RNA ligase-like domain DUF1374 PF07118.6 KII73606.1 - 0.024 14.7 0.7 0.063 13.3 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1374) DUF1075 PF06388.6 KII73606.1 - 0.036 13.7 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) ATG27 PF09451.5 KII73606.1 - 0.096 11.8 0.2 0.19 10.9 0.1 1.3 1 1 0 1 1 1 0 Autophagy-related protein 27 DUF4349 PF14257.1 KII73606.1 - 0.1 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) ATP-synt_8 PF00895.15 KII73607.1 - 0.0025 17.9 0.1 0.0061 16.7 0.0 1.7 1 0 0 1 1 1 1 ATP synthase protein 8 DUF2969 PF11184.3 KII73610.1 - 0.073 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2969) DUF3375 PF11855.3 KII73611.1 - 0.16 10.7 0.0 0.21 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) Ldl_recept_a PF00057.13 KII73612.1 - 1.4e-22 79.2 48.2 4.7e-13 48.7 11.3 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A SNAP PF14938.1 KII73613.1 - 4e-08 32.7 0.1 5e-08 32.4 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII73613.1 - 0.0059 16.5 0.8 0.27 11.1 0.0 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KII73613.1 - 0.04 13.5 3.7 2.2 7.9 0.3 3.1 1 1 0 2 2 2 0 TPR repeat TPR_10 PF13374.1 KII73613.1 - 0.11 12.4 0.0 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII73613.1 - 0.17 11.7 1.0 12 5.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 KII73613.1 - 3.2 7.8 7.0 1.8 8.6 0.4 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 KII73613.1 - 5.6 6.9 6.8 28 4.7 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Kelch_3 PF13415.1 KII73614.1 - 1.1e-22 79.5 1.2 8.7e-05 22.5 0.1 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 KII73614.1 - 7.7e-22 76.4 10.5 0.00017 21.5 0.2 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 KII73614.1 - 1.5e-20 72.4 7.7 4.3e-06 26.1 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 KII73614.1 - 3.7e-18 65.0 11.1 7.9e-05 22.3 0.0 4.7 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KII73614.1 - 4.3e-09 35.7 10.6 0.015 15.0 0.1 5.4 5 1 0 5 5 5 4 Kelch motif Kelch_5 PF13854.1 KII73614.1 - 3.7e-06 26.7 6.3 0.48 10.4 0.0 5.0 5 0 0 5 5 5 2 Kelch motif DUF3839 PF12943.2 KII73617.1 - 0.0003 20.0 0.1 0.00033 19.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3839) Pet191_N PF10203.4 KII73617.1 - 0.44 10.6 3.0 0.54 10.3 1.3 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 rve PF00665.21 KII73618.1 - 5e-05 23.4 0.0 8.4e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII73618.1 - 0.018 14.5 0.1 0.036 13.5 0.0 1.6 2 0 0 2 2 2 0 Integrase core domain rve PF00665.21 KII73619.1 - 0.085 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Matrilin_ccoil PF10393.4 KII73620.1 - 0.019 14.3 0.1 0.083 12.2 0.1 2.0 1 1 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin Ras PF00071.17 KII73621.1 - 1.3e-59 200.2 0.6 1.5e-59 199.9 0.4 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII73621.1 - 6.9e-19 68.4 0.0 1.1e-18 67.8 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII73621.1 - 8.1e-16 57.7 0.1 1.1e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KII73621.1 - 3e-06 27.1 0.0 5.1e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 KII73621.1 - 1.1e-05 24.6 0.1 1.6e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 KII73621.1 - 1.4e-05 25.2 0.0 3.1e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 KII73621.1 - 3.2e-05 23.4 0.1 9.2e-05 21.9 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 KII73621.1 - 0.00042 19.5 0.0 0.0014 17.8 0.0 1.6 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 KII73621.1 - 0.0036 16.5 0.3 0.0087 15.2 0.1 1.7 2 1 0 2 2 2 1 Protein of unknown function, DUF258 AAA_15 PF13175.1 KII73621.1 - 0.0059 15.6 0.0 0.0081 15.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 KII73621.1 - 0.0078 16.1 0.0 0.016 15.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KII73621.1 - 0.014 15.1 0.0 0.024 14.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DBI_PRT PF02277.12 KII73621.1 - 0.02 14.0 0.0 0.04 13.0 0.0 1.5 2 0 0 2 2 2 0 Phosphoribosyltransferase AAA_16 PF13191.1 KII73621.1 - 0.02 14.9 0.1 0.049 13.6 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.13 KII73621.1 - 0.038 13.2 0.2 2.6 7.3 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B ABC_tran PF00005.22 KII73621.1 - 0.042 14.1 0.2 0.06 13.6 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.1 KII73621.1 - 0.046 13.3 0.1 0.12 11.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 KII73621.1 - 0.052 13.2 0.2 0.28 10.9 0.1 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 KII73621.1 - 0.054 12.9 0.0 0.16 11.4 0.0 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 KII73621.1 - 0.072 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MCM PF00493.18 KII73621.1 - 0.072 11.8 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 MCM2/3/5 family RNA_helicase PF00910.17 KII73621.1 - 0.079 13.1 0.2 0.45 10.7 0.0 2.3 1 1 1 2 2 2 0 RNA helicase AAA_29 PF13555.1 KII73621.1 - 0.1 12.1 0.0 0.27 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 KII73621.1 - 0.12 11.7 0.1 0.24 10.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 KII73621.1 - 0.13 12.5 0.0 0.31 11.2 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RRN3 PF05327.6 KII73622.1 - 0.015 13.4 0.3 0.018 13.1 0.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pheromone PF08015.6 KII73622.1 - 2.3 9.1 7.3 4.8 8.0 5.0 1.5 1 0 0 1 1 1 0 Fungal mating-type pheromone DUF1478 PF07349.6 KII73624.1 - 0.12 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1478) HTH_Tnp_IS630 PF01710.11 KII73624.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Transposase Serpin PF00079.15 KII73625.1 - 4.3e-12 45.8 0.0 5.2e-12 45.5 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73626.1 - 4e-11 42.6 0.1 4.8e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73627.1 - 5.4e-16 58.6 0.9 6.3e-16 58.4 0.6 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73628.1 - 4e-07 29.5 0.0 4.2e-07 29.4 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73629.1 - 8.9e-14 51.3 0.2 1.1e-13 51.0 0.1 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Adenine_glyco PF03352.8 KII73629.1 - 0.05 13.1 0.1 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyladenine glycosylase Serpin PF00079.15 KII73630.1 - 4e-13 49.2 5.0 4.9e-13 48.9 3.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DOT1 PF08123.8 KII73630.1 - 0.028 13.7 1.4 0.036 13.3 1.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 HARP PF07443.8 KII73630.1 - 0.13 11.6 0.7 4.8 6.6 0.1 2.6 2 0 0 2 2 2 0 HepA-related protein (HARP) Serpin PF00079.15 KII73631.1 - 3e-12 46.3 2.5 3.7e-12 46.0 1.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73632.1 - 2.4e-35 122.3 5.4 2.7e-35 122.1 3.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73633.1 - 2.5e-37 128.8 4.5 2.9e-37 128.6 3.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73634.1 - 1.7e-07 30.7 1.8 2e-07 30.4 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) HTH_Tnp_Tc3_2 PF01498.13 KII73635.1 - 0.011 15.7 0.1 0.023 14.7 0.1 1.6 2 0 0 2 2 2 0 Transposase HTH_32 PF13565.1 KII73635.1 - 0.026 15.3 0.0 0.036 14.8 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Serpin PF00079.15 KII73637.1 - 4.8e-05 22.6 0.8 5.2e-05 22.5 0.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1878 PF08963.5 KII73638.1 - 0.025 14.7 1.5 0.055 13.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1878) uDENN PF03456.13 KII73639.1 - 5.4e-10 39.1 0.5 1.2e-09 37.9 0.4 1.6 1 0 0 1 1 1 1 uDENN domain DUF2464 PF10240.4 KII73639.1 - 0.0025 17.2 0.0 0.0042 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2464) Pkinase PF00069.20 KII73640.1 - 5.4e-10 38.8 0.1 1.9e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII73640.1 - 6.7e-09 35.1 0.2 1.7e-08 33.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase OSR1_C PF12202.3 KII73640.1 - 1.1 8.9 4.3 10 5.8 0.1 3.1 3 0 0 3 3 3 0 Oxidative-stress-responsive kinase 1 C terminal FCH PF00611.18 KII73641.1 - 0.00063 19.8 0.7 0.00063 19.8 0.5 2.4 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Phage_C PF12025.3 KII73641.1 - 0.012 15.5 5.7 0.15 12.0 0.2 3.5 2 1 2 4 4 4 0 Phage protein C TPR_20 PF14561.1 KII73641.1 - 0.099 12.7 0.9 0.23 11.5 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3496 PF12001.3 KII73641.1 - 0.34 11.1 3.6 0.13 12.5 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) Serpin PF00079.15 KII73645.1 - 7.1e-26 91.2 1.4 7.6e-26 91.1 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4049 PF13258.1 KII73646.1 - 0.0028 16.6 0.0 0.0031 16.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4049) Serpin PF00079.15 KII73646.1 - 0.004 16.3 0.0 0.0041 16.3 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) NDUF_B8 PF05821.6 KII73646.1 - 0.047 13.3 0.1 0.065 12.8 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) DUF1796 PF08795.5 KII73646.1 - 0.076 12.6 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) DUF3419 PF11899.3 KII73653.1 - 0.018 13.7 0.1 0.031 12.9 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3419) CENP-I PF07778.6 KII73656.1 - 0.054 11.6 0.2 0.074 11.2 0.1 1.1 1 0 0 1 1 1 0 Mis6 Noelin-1 PF12308.3 KII73657.1 - 0.17 11.6 2.9 0.21 11.4 2.0 1.1 1 0 0 1 1 1 0 Neurogenesis glycoprotein rve PF00665.21 KII73658.1 - 6.7e-07 29.4 0.0 1e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain NTNH_C PF08470.5 KII73658.1 - 0.0063 16.1 0.4 0.0084 15.7 0.2 1.3 1 0 0 1 1 1 1 Nontoxic nonhaemagglutinin C-terminal DUF1765 PF08578.5 KII73658.1 - 0.12 12.4 1.3 0.17 11.9 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1765) adh_short PF00106.20 KII73660.1 - 6.7e-15 55.3 0.0 1e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KII73660.1 - 1.2e-06 28.3 0.0 1.8e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 KII73660.1 - 7.6e-06 25.5 0.0 9.4e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 KII73660.1 - 0.00065 19.7 0.0 0.66 9.9 0.0 2.4 2 0 0 2 2 2 2 NADH(P)-binding 3Beta_HSD PF01073.14 KII73660.1 - 0.03 13.0 0.0 0.045 12.4 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 KII73660.1 - 0.12 11.2 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DDE_3 PF13358.1 KII73661.1 - 5.7e-24 84.5 0.0 8.6e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_38 PF13936.1 KII73661.1 - 0.016 14.7 0.1 1.2 8.7 0.1 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_32 PF13565.1 KII73661.1 - 0.017 15.9 0.0 0.032 15.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.10 KII73661.1 - 0.1 12.4 0.8 0.21 11.4 0.1 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase NUT_N PF12881.2 KII73661.1 - 0.13 11.4 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 NUT protein N terminus RNA_pol_Rpc34 PF05158.7 KII73662.1 - 0.033 13.3 0.2 0.046 12.8 0.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit Stork_head PF10264.4 KII73662.1 - 0.11 12.7 1.1 1.3 9.2 0.0 2.2 1 1 1 2 2 2 0 Winged helix Storkhead-box1 domain DNA_gyraseA_C PF03989.8 KII73665.1 - 0.035 13.3 0.0 0.07 12.4 0.0 1.5 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller CUE PF02845.11 KII73666.1 - 1.1e-06 27.9 0.0 0.085 12.3 0.0 2.9 2 0 0 2 2 2 2 CUE domain Nuclease_act PF08133.6 KII73666.1 - 0.0014 18.0 0.1 0.15 11.5 0.0 3.3 4 0 0 4 4 4 2 Anticodon nuclease activator family KID PF02524.9 KII73666.1 - 0.0018 17.9 1.4 4.5 7.8 0.1 3.1 2 0 0 2 2 2 2 KID repeat OstA_2 PF13100.1 KII73666.1 - 0.0055 16.0 0.2 2.8 7.2 0.0 2.2 1 1 1 2 2 2 2 OstA-like protein PsbN PF02468.10 KII73666.1 - 0.047 13.2 0.0 16 5.1 0.0 2.7 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) Baculo_PEP_N PF04512.7 KII73666.1 - 0.049 13.6 0.1 4 7.4 0.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, N terminus rpo132 PF12415.3 KII73666.1 - 0.06 12.3 0.8 12 4.9 0.1 2.8 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase S6PP_C PF08472.5 KII73666.1 - 0.074 12.6 0.0 13 5.3 0.0 2.2 2 0 0 2 2 2 0 Sucrose-6-phosphate phosphohydrolase C-terminal Acetyltransf_4 PF13420.1 KII73666.1 - 0.1 12.5 0.5 9.6 6.1 0.0 2.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Tudor-knot PF11717.3 KII73666.1 - 0.26 11.0 2.7 11 5.8 0.2 2.3 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Gpi1 PF05024.10 KII73667.1 - 0.091 12.4 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 N-acetylglucosaminyl transferase component (Gpi1) BNR PF02012.15 KII73669.1 - 0.0021 17.6 1.2 3.1 7.9 0.0 3.2 3 0 0 3 3 3 2 BNR/Asp-box repeat VKOR PF07884.9 KII73671.1 - 0.038 13.8 0.4 0.052 13.3 0.2 1.2 1 0 0 1 1 1 0 Vitamin K epoxide reductase family DUF4234 PF14018.1 KII73674.1 - 0.088 12.5 0.1 0.18 11.5 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) DDE_Tnp_IS1595 PF12762.2 KII73676.1 - 2.6e-06 27.3 0.0 2.8e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF2982 PF11201.3 KII73676.1 - 0.07 12.4 0.0 0.65 9.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2982) EzrA PF06160.7 KII73677.1 - 0.024 12.8 0.9 0.027 12.6 0.2 1.4 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Acatn PF13000.2 KII73678.1 - 4.8e-08 31.9 2.6 7.1e-08 31.4 1.8 1.3 1 1 0 1 1 1 1 Acetyl-coenzyme A transporter 1 DUF4418 PF14387.1 KII73678.1 - 0.014 15.1 2.5 0.085 12.6 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4418) DUF4234 PF14018.1 KII73678.1 - 2.1 8.1 4.8 6.6 6.5 3.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4234) TMEM107 PF14995.1 KII73678.1 - 2.4 8.2 6.5 4.8 7.3 1.2 2.1 1 1 1 2 2 2 0 Transmembrane protein DUF3819 PF12842.2 KII73680.1 - 0.025 14.2 0.0 0.026 14.1 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3819) MMtag PF10159.4 KII73681.1 - 3.8e-24 84.5 1.0 3.8e-24 84.5 0.7 2.1 2 0 0 2 2 2 1 Kinase phosphorylation protein Rot1 PF10681.4 KII73681.1 - 0.3 10.4 3.9 0.1 11.9 1.0 1.5 2 0 0 2 2 2 0 Chaperone for protein-folding within the ER, fungal Beach PF02138.13 KII73683.1 - 2.3e-102 342.0 0.8 2.3e-102 342.0 0.5 2.6 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.1 KII73683.1 - 7.2e-08 32.2 0.1 2.1e-07 30.7 0.1 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 KII73683.1 - 6.3e-06 25.8 1.2 0.00024 20.8 0.0 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat Laminin_G_3 PF13385.1 KII73683.1 - 8.6e-05 22.8 0.0 0.00019 21.7 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EcoEI_R_C PF08463.5 KII73685.1 - 0.022 14.5 0.7 0.042 13.7 0.4 1.5 1 1 0 1 1 1 0 EcoEI R protein C-terminal DUF948 PF06103.6 KII73685.1 - 0.049 13.4 2.2 0.087 12.6 0.2 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1027 PF06265.6 KII73685.1 - 0.091 12.6 0.5 0.59 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1027) DUF3641 PF12345.3 KII73686.1 - 0.064 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3641) EcoEI_R_C PF08463.5 KII73687.1 - 0.022 14.5 0.7 0.042 13.7 0.4 1.5 1 1 0 1 1 1 0 EcoEI R protein C-terminal DUF948 PF06103.6 KII73687.1 - 0.049 13.4 2.2 0.087 12.6 0.2 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1027 PF06265.6 KII73687.1 - 0.091 12.6 0.5 0.59 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1027) Serpin PF00079.15 KII73690.1 - 1.1e-45 156.4 0.8 1.3e-45 156.1 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_3 PF13358.1 KII73691.1 - 7.1e-33 113.4 0.0 1e-32 112.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII73691.1 - 0.019 15.0 0.0 0.051 13.6 0.0 1.8 1 0 0 1 1 1 0 Transposase rve PF00665.21 KII73691.1 - 0.042 13.9 0.0 0.1 12.7 0.0 1.9 2 1 0 2 2 2 0 Integrase core domain Zot PF05707.7 KII73691.1 - 0.09 12.2 0.0 0.15 11.5 0.0 1.5 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) Pentapeptide_4 PF13599.1 KII73694.1 - 0.078 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) RWD PF05773.17 KII73695.1 - 5.2e-07 29.5 0.4 1.1e-06 28.5 0.3 1.5 1 0 0 1 1 1 1 RWD domain PcF PF09461.5 KII73695.1 - 3.4 7.6 5.4 59 3.6 2.1 2.8 2 1 1 3 3 3 0 Phytotoxin PcF protein Gp_dh_C PF02800.15 KII73697.1 - 2e-58 196.3 0.0 2.7e-58 195.8 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 KII73697.1 - 2.7e-51 173.4 0.0 4.8e-51 172.6 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DUF2272 PF10030.4 KII73697.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2272) Peptidase_M1 PF01433.15 KII73698.1 - 9.4e-77 258.6 0.7 2e-76 257.5 0.2 1.8 2 0 0 2 2 2 1 Peptidase family M1 ERAP1_C PF11838.3 KII73698.1 - 2.6e-34 118.9 0.0 3.7e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 KII73698.1 - 8e-20 71.1 0.1 1.3e-19 70.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase MA superfamily DUF1360 PF07098.6 KII73698.1 - 0.018 14.7 0.1 0.057 13.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) zf-H2C2_2 PF13465.1 KII73700.1 - 6.7e-12 45.0 8.6 2.3e-08 33.8 0.5 4.6 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.21 KII73700.1 - 8.6e-11 41.5 26.7 6.4e-05 23.0 1.1 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KII73700.1 - 1.8e-08 34.1 21.0 0.0073 16.5 0.8 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KII73700.1 - 0.0085 16.2 4.6 0.59 10.3 0.1 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding IBR PF01485.16 KII73700.1 - 0.49 10.2 4.2 2.5 8.0 2.9 2.0 1 1 0 1 1 1 0 IBR domain zf-met PF12874.2 KII73700.1 - 4 7.7 9.2 4.6 7.5 0.3 2.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF4261 PF14080.1 KII73701.1 - 0.076 12.8 0.0 0.62 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4261) IDO PF01231.13 KII73701.1 - 0.14 10.5 0.1 0.42 8.9 0.1 1.8 1 1 0 1 1 1 0 Indoleamine 2,3-dioxygenase GCS PF03074.11 KII73702.1 - 5.7e-68 229.6 7.0 2.3e-45 155.2 4.5 2.7 1 1 1 2 2 2 2 Glutamate-cysteine ligase Snapin_Pallidin PF14712.1 KII73704.1 - 0.11 12.7 0.5 1.4 9.2 0.0 2.1 2 0 0 2 2 2 0 Snapin/Pallidin DUF247 PF03140.10 KII73705.1 - 0.0026 16.8 0.1 0.0033 16.4 0.1 1.2 1 0 0 1 1 1 1 Plant protein of unknown function PHD PF00628.24 KII73705.1 - 0.082 12.6 19.1 0.15 11.7 11.6 2.4 2 0 0 2 2 2 0 PHD-finger Ribosomal_L9_N PF01281.14 KII73706.1 - 3.1e-13 48.7 0.0 5.2e-13 47.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain tRNA-synt_His PF13393.1 KII73707.1 - 1.9e-45 155.2 0.0 2.4e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 KII73707.1 - 9e-18 64.4 0.0 1.6e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KII73707.1 - 7.7e-15 54.6 0.2 2e-14 53.2 0.1 1.8 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.2 KII73707.1 - 6.9e-07 28.6 2.1 1.1e-06 28.0 1.4 1.3 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.15 KII73707.1 - 0.00018 20.4 0.0 0.0065 15.2 0.0 2.6 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 KII73707.1 - 0.0021 17.3 0.3 0.0034 16.6 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) Ribosomal_L29 PF00831.18 KII73708.1 - 4.8e-15 54.9 6.0 1.1e-14 53.8 4.2 1.6 1 0 0 1 1 1 1 Ribosomal L29 protein DUF4283 PF14111.1 KII73708.1 - 0.071 12.1 0.3 0.089 11.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) RIO1 PF01163.17 KII73709.1 - 2.7e-61 206.2 0.0 2.7e-61 206.2 0.0 2.1 3 0 0 3 3 3 1 RIO1 family APH PF01636.18 KII73709.1 - 2.8e-05 23.9 0.0 0.065 12.9 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 KII73709.1 - 7e-05 21.9 0.1 0.11 11.5 0.0 2.5 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1682 PF07946.9 KII73709.1 - 6 5.6 18.0 9.9 4.9 12.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DDE_3 PF13358.1 KII73710.1 - 4e-05 23.3 0.0 0.00037 20.2 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease PAX PF00292.13 KII73710.1 - 0.053 13.2 0.1 0.085 12.5 0.0 1.2 1 0 0 1 1 1 0 'Paired box' domain ALS2CR8 PF15299.1 KII73710.1 - 0.065 12.8 0.0 0.096 12.2 0.0 1.2 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Sds3 PF08598.6 KII73712.1 - 0.0098 15.4 2.9 0.011 15.2 1.3 1.5 1 1 1 2 2 2 1 Sds3-like ING PF12998.2 KII73712.1 - 0.41 10.9 4.0 0.62 10.3 0.3 2.3 1 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Reo_sigmaC PF04582.7 KII73713.1 - 1.4e-05 24.4 3.2 1.4e-05 24.4 2.3 3.0 1 1 2 3 3 3 1 Reovirus sigma C capsid protein BLOC1_2 PF10046.4 KII73713.1 - 0.00061 19.8 5.0 0.00061 19.8 3.5 5.4 2 2 3 5 5 5 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3407 PF11887.3 KII73713.1 - 0.0032 16.7 4.9 0.11 11.7 0.2 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3407) HALZ PF02183.13 KII73713.1 - 0.013 15.1 0.1 0.013 15.1 0.1 5.0 5 1 1 6 6 6 0 Homeobox associated leucine zipper CP12 PF02672.10 KII73713.1 - 0.15 12.5 3.5 0.26 11.7 0.2 3.0 3 0 0 3 3 3 0 CP12 domain I-set PF07679.11 KII73714.1 - 4.5e-30 103.3 0.4 4.1e-12 45.7 0.0 5.5 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_2 PF13895.1 KII73714.1 - 4.4e-17 61.9 2.0 4.6e-05 23.4 0.0 5.3 6 0 0 6 6 6 3 Immunoglobulin domain Ig_3 PF13927.1 KII73714.1 - 2.6e-16 59.8 6.4 2.3e-08 34.3 0.0 5.2 5 1 0 5 5 5 3 Immunoglobulin domain V-set PF07686.12 KII73714.1 - 2.4e-15 56.4 7.2 0.001 18.9 0.0 6.4 6 1 0 6 6 6 3 Immunoglobulin V-set domain ig PF00047.20 KII73714.1 - 4.9e-14 52.2 1.6 1.7e-06 28.0 0.0 5.0 5 1 0 5 5 5 2 Immunoglobulin domain fn3 PF00041.16 KII73714.1 - 1.2e-09 38.1 0.2 1.2e-09 38.1 0.1 2.3 3 0 0 3 3 3 1 Fibronectin type III domain C2-set_2 PF08205.7 KII73714.1 - 0.00013 21.7 0.1 1.9 8.4 0.0 3.3 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Herpes_gE PF02480.11 KII73714.1 - 0.00051 18.4 1.0 0.1 10.8 0.0 3.5 3 1 1 4 4 4 1 Alphaherpesvirus glycoprotein E CRT-like PF08627.5 KII73715.1 - 0.16 11.9 1.2 0.47 10.4 0.8 1.8 1 0 0 1 1 1 0 CRT-like Cyclin_C PF02984.14 KII73717.1 - 0.0051 16.7 0.0 0.0081 16.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain CMV_1a PF12467.3 KII73717.1 - 0.016 15.5 0.3 0.021 15.1 0.2 1.1 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family C-C_Bond_Lyase PF15617.1 KII73717.1 - 0.016 14.0 0.1 0.021 13.6 0.1 1.1 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold PP2 PF14299.1 KII73717.1 - 0.1 12.0 0.4 0.19 11.0 0.0 1.6 2 0 0 2 2 2 0 Phloem protein 2 BNR PF02012.15 KII73720.1 - 0.0015 18.0 0.9 0.21 11.5 0.1 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat Cys_knot PF00007.17 KII73721.1 - 0.28 11.2 2.3 5.8 7.0 0.0 2.3 1 1 0 2 2 2 0 Cystine-knot domain BNR PF02012.15 KII73722.1 - 1.6e-06 27.0 0.3 0.028 14.1 0.0 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat RVP PF00077.15 KII73723.1 - 1.2e-05 25.1 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII73723.1 - 0.08 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease BNR PF02012.15 KII73726.1 - 3.3e-05 23.0 0.2 0.55 10.2 0.0 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat MCM PF00493.18 KII73728.1 - 5.6e-14 51.6 0.1 7.3e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM PF00493.18 KII73729.1 - 1.5e-38 132.4 0.0 1.5e-38 132.4 0.0 1.0 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 KII73729.1 - 0.00068 18.8 0.0 0.0085 15.2 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 KII73729.1 - 0.027 14.0 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DNAJ_related PF12339.3 KII73730.1 - 0.093 12.6 4.2 0.19 11.6 2.9 1.7 1 1 0 1 1 1 0 DNA-J related protein LRS4 PF10422.4 KII73730.1 - 0.13 11.5 7.5 0.14 11.4 5.2 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Ribosomal_L17 PF01196.14 KII73731.1 - 4.8e-13 49.4 0.1 6.7e-13 49.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 COX6B PF02297.12 KII73732.1 - 0.065 13.2 2.1 0.13 12.3 1.4 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb WRW PF10206.4 KII73732.1 - 0.12 12.3 0.5 1.2 9.2 0.1 2.1 1 1 1 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f DDE_Tnp_IS1595 PF12762.2 KII73733.1 - 1.2e-12 47.8 0.0 2.6e-12 46.8 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain ShK PF01549.19 KII73733.1 - 0.059 13.7 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 ShK domain-like CAP PF00188.21 KII73735.1 - 8.9e-22 77.8 0.0 3.5e-17 63.0 0.0 2.8 2 1 0 2 2 2 2 Cysteine-rich secretory protein family Vps35 PF03635.12 KII73736.1 - 2.5e-19 68.9 4.3 4.7e-19 68.0 3.0 1.3 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 YoaP PF14268.1 KII73736.1 - 0.062 12.5 0.1 0.12 11.5 0.1 1.5 1 0 0 1 1 1 0 YoaP-like RIX1 PF08167.7 KII73736.1 - 0.063 12.9 2.3 2.9 7.5 0.1 3.2 4 0 0 4 4 4 0 rRNA processing/ribosome biogenesis zf-C3Hc3H PF13891.1 KII73736.1 - 3.7 7.7 5.9 34 4.6 0.3 3.1 3 0 0 3 3 3 0 Potential DNA-binding domain Vps35 PF03635.12 KII73737.1 - 1e-11 43.8 0.5 1.3e-11 43.4 0.3 1.3 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Cullin_Nedd8 PF10557.4 KII73738.1 - 0.066 13.0 0.1 0.25 11.2 0.1 1.9 2 0 0 2 2 2 0 Cullin protein neddylation domain Pribosyltran PF00156.22 KII73740.1 - 1.8e-24 85.8 0.0 2.2e-24 85.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KII73740.1 - 4.6e-05 22.7 0.0 0.0034 16.6 0.0 2.1 2 0 0 2 2 2 2 Uracil phosphoribosyltransferase DDE_Tnp_1_7 PF13843.1 KII73741.1 - 0.00011 21.3 0.3 0.00015 20.9 0.2 1.1 1 0 0 1 1 1 1 Transposase IS4 Dimer_Tnp_hAT PF05699.9 KII73747.1 - 6.5e-07 28.8 0.4 8e-05 22.1 0.3 2.3 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region DEAD PF00270.24 KII73748.1 - 5.1e-42 143.2 0.1 1.7e-41 141.5 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII73748.1 - 2.5e-20 72.1 0.0 6.7e-20 70.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 KII73748.1 - 7.1e-14 51.1 0.2 1.9e-13 49.7 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.10 KII73748.1 - 2.5e-10 40.5 0.1 5.2e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KII73748.1 - 0.00064 19.8 1.2 0.0028 17.7 0.8 2.0 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.1 KII73748.1 - 0.019 14.0 0.1 0.051 12.6 0.0 1.7 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.24 KII73749.1 - 2.6e-26 92.1 0.0 3.1e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KII73749.1 - 0.0031 17.3 0.0 0.0036 17.1 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ShK PF01549.19 KII73750.1 - 1.5e-06 28.4 9.0 2.4e-06 27.7 6.3 1.4 1 0 0 1 1 1 1 ShK domain-like Torsin PF06309.6 KII73750.1 - 0.11 12.4 0.2 0.16 11.8 0.1 1.2 1 0 0 1 1 1 0 Torsin PA14 PF07691.7 KII73751.1 - 0.027 14.1 0.0 0.08 12.5 0.0 1.8 2 0 0 2 2 2 0 PA14 domain DUF4200 PF13863.1 KII73753.1 - 0.023 14.6 2.3 0.023 14.6 1.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Peptidase_C9 PF01707.11 KII73753.1 - 0.027 14.0 0.1 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C9 Phage_Mu_Gam PF07352.7 KII73753.1 - 0.13 11.8 2.8 0.23 10.9 1.9 1.4 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein SYCE1 PF15233.1 KII73753.1 - 0.23 11.3 4.3 0.38 10.6 3.0 1.4 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 IncA PF04156.9 KII73753.1 - 0.28 10.7 1.9 0.32 10.5 1.3 1.2 1 0 0 1 1 1 0 IncA protein CASP_C PF08172.7 KII73753.1 - 1 8.3 4.8 6.5 5.7 1.7 2.1 1 1 0 2 2 2 0 CASP C terminal CENP-F_leu_zip PF10473.4 KII73753.1 - 1.7 8.5 8.7 0.18 11.6 2.3 1.9 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.10 KII73753.1 - 2.7 7.5 9.0 0.042 13.3 1.4 1.6 2 0 0 2 2 2 0 Septum formation initiator ATP_bind_3 PF01171.15 KII73755.1 - 0.098 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 PP-loop family Kelch_6 PF13964.1 KII73757.1 - 1.7e-19 69.0 6.8 4.2e-06 26.6 0.4 3.2 1 1 2 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII73757.1 - 7.2e-16 57.8 0.7 3.4e-06 27.0 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73757.1 - 1.1e-14 53.7 5.9 3e-05 23.4 2.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII73757.1 - 2.2e-08 33.8 8.4 0.0025 17.7 0.5 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 KII73757.1 - 6.1e-08 32.3 10.6 0.0032 17.1 0.2 3.9 3 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII73757.1 - 5.4e-06 25.9 3.3 0.02 14.6 0.0 2.9 3 0 0 3 3 3 2 Kelch motif Rax2 PF12768.2 KII73757.1 - 0.0038 16.4 0.1 0.033 13.3 0.0 2.1 1 1 0 2 2 2 1 Cortical protein marker for cell polarity AA_permease_C PF13906.1 KII73757.1 - 1.3 8.9 8.9 1.4 8.8 0.1 3.5 4 0 0 4 4 4 0 C-terminus of AA_permease Kelch_6 PF13964.1 KII73758.1 - 0.091 12.9 0.8 2.9 8.2 0.1 2.3 1 1 1 2 2 2 0 Kelch motif WD40 PF00400.27 KII73760.1 - 1.1e-07 31.4 8.6 0.081 12.8 0.0 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.6 KII73760.1 - 0.0007 19.3 0.2 0.1 12.2 0.0 2.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 KII73760.1 - 0.017 14.5 0.0 0.53 9.8 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2649 PF10854.3 KII73761.1 - 0.076 13.1 7.7 0.084 13.0 4.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2649) PalH PF08733.5 KII73761.1 - 0.51 9.1 7.3 0.67 8.7 5.1 1.1 1 0 0 1 1 1 0 PalH/RIM21 Baculo_11_kDa PF06143.6 KII73761.1 - 0.72 9.2 7.4 0.53 9.6 3.9 1.6 1 1 1 2 2 2 0 Baculovirus 11 kDa family Ndc1_Nup PF09531.5 KII73763.1 - 0.2 10.0 1.8 0.25 9.7 1.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DTHCT PF08070.6 KII73764.1 - 6.5 7.4 19.9 4.3 8.0 0.1 4.3 4 1 0 4 4 4 0 DTHCT (NUC029) region Peptidase_S8 PF00082.17 KII73767.1 - 3.5e-43 147.7 0.1 5.1e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 KII73767.1 - 1e-15 57.2 0.1 2.1e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Abi PF02517.11 KII73768.1 - 0.0047 17.0 0.2 0.0082 16.2 0.1 1.4 1 0 0 1 1 1 1 CAAX protease self-immunity Rogdi_lz PF10259.4 KII73770.1 - 5.5e-10 38.8 0.5 7.4e-10 38.3 0.3 1.2 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein COG2 PF06148.6 KII73771.1 - 2e-07 30.9 5.1 2.9e-07 30.4 3.6 1.3 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Prefoldin_2 PF01920.15 KII73771.1 - 2.7e-05 23.8 1.9 2.7e-05 23.8 1.3 1.6 2 0 0 2 2 1 1 Prefoldin subunit CorA PF01544.13 KII73771.1 - 0.0074 15.3 3.8 0.0076 15.3 2.6 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein V_ATPase_I PF01496.14 KII73771.1 - 0.0083 14.0 2.7 0.009 13.9 1.9 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Ax_dynein_light PF10211.4 KII73771.1 - 0.0088 15.8 2.1 0.011 15.6 1.4 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain APG6 PF04111.7 KII73771.1 - 0.0091 15.0 2.6 0.0097 14.9 1.8 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 PspA_IM30 PF04012.7 KII73771.1 - 0.0095 15.3 0.6 0.0095 15.3 0.4 1.2 1 0 0 1 1 1 1 PspA/IM30 family TMF_DNA_bd PF12329.3 KII73771.1 - 0.011 15.5 3.1 0.021 14.6 2.1 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Filament PF00038.16 KII73771.1 - 0.011 15.1 2.6 0.016 14.6 1.8 1.3 1 1 0 1 1 1 0 Intermediate filament protein bZIP_1 PF00170.16 KII73771.1 - 0.013 15.4 4.3 0.067 13.1 1.2 2.6 2 1 1 3 3 2 0 bZIP transcription factor FliD_C PF07195.7 KII73771.1 - 0.013 14.7 0.9 0.015 14.5 0.6 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus FliJ PF02050.11 KII73771.1 - 0.015 15.3 3.4 0.029 14.4 2.4 1.6 1 1 0 1 1 1 0 Flagellar FliJ protein Rootletin PF15035.1 KII73771.1 - 0.017 15.1 2.7 0.023 14.6 1.9 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Uds1 PF15456.1 KII73771.1 - 0.017 15.1 1.6 0.031 14.2 1.1 1.4 1 1 0 1 1 1 0 Up-regulated During Septation Tektin PF03148.9 KII73771.1 - 0.017 13.6 1.8 0.02 13.4 1.2 1.2 1 0 0 1 1 1 0 Tektin family AAA_13 PF13166.1 KII73771.1 - 0.018 13.5 2.0 0.019 13.4 1.4 1.0 1 0 0 1 1 1 0 AAA domain DUF4446 PF14584.1 KII73771.1 - 0.02 14.6 0.6 0.026 14.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DivIC PF04977.10 KII73771.1 - 0.021 14.2 2.6 0.021 14.2 1.8 1.7 2 0 0 2 2 1 0 Septum formation initiator Tropomyosin_1 PF12718.2 KII73771.1 - 0.022 14.6 3.5 0.039 13.7 2.4 1.4 1 0 0 1 1 1 0 Tropomyosin like Syntaxin-6_N PF09177.6 KII73771.1 - 0.023 15.0 2.3 0.038 14.3 1.1 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal CENP-F_leu_zip PF10473.4 KII73771.1 - 0.026 14.3 3.8 0.026 14.3 2.6 1.8 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4449 PF14613.1 KII73771.1 - 0.03 14.2 0.1 0.04 13.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) Prefoldin PF02996.12 KII73771.1 - 0.031 13.9 2.4 0.031 13.9 1.7 1.9 1 1 0 2 2 2 0 Prefoldin subunit Barstar PF01337.13 KII73771.1 - 0.032 14.0 0.2 0.058 13.2 0.1 1.5 1 1 0 1 1 1 0 Barstar (barnase inhibitor) DUF3490 PF11995.3 KII73771.1 - 0.032 13.7 0.7 0.043 13.3 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) DUF342 PF03961.8 KII73771.1 - 0.036 12.5 2.9 0.039 12.3 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Snf7 PF03357.16 KII73771.1 - 0.038 13.3 1.2 0.073 12.4 0.8 1.4 1 0 0 1 1 1 0 Snf7 TMF_TATA_bd PF12325.3 KII73771.1 - 0.041 13.6 2.9 0.052 13.2 1.5 1.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Vps51 PF08700.6 KII73771.1 - 0.057 13.2 2.7 11 5.9 1.9 2.5 1 1 0 1 1 1 0 Vps51/Vps67 DDE_Tnp_IS240 PF13610.1 KII73771.1 - 0.057 13.3 0.5 0.16 11.9 0.2 1.7 1 1 1 2 2 2 0 DDE domain PhaP_Bmeg PF09602.5 KII73771.1 - 0.058 13.2 2.4 0.17 11.6 0.9 1.9 1 1 1 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Spc24 PF08286.6 KII73771.1 - 0.059 13.0 0.7 0.059 13.0 0.5 1.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 4HB_MCP_1 PF12729.2 KII73771.1 - 0.064 12.6 6.9 0.13 11.6 4.8 1.4 1 1 0 1 1 1 0 Four helix bundle sensory module for signal transduction Borrelia_lipo_1 PF05714.6 KII73771.1 - 0.068 12.2 7.6 0.086 11.9 5.3 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein NuA4 PF09340.5 KII73771.1 - 0.074 12.6 1.6 0.14 11.7 1.1 1.5 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 HALZ PF02183.13 KII73771.1 - 0.074 12.7 1.5 0.13 11.9 1.1 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper IncA PF04156.9 KII73771.1 - 0.076 12.6 7.6 0.081 12.5 4.9 1.3 1 1 0 1 1 1 0 IncA protein Mod_r PF07200.8 KII73771.1 - 0.091 12.6 6.5 0.22 11.4 3.1 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4407 PF14362.1 KII73771.1 - 0.098 11.5 0.7 0.11 11.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.6 KII73771.1 - 0.099 10.1 1.2 0.13 9.7 0.8 1.2 1 0 0 1 1 1 0 Prominin DUF4200 PF13863.1 KII73771.1 - 0.11 12.4 4.6 0.13 12.1 2.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) COG5 PF10392.4 KII73771.1 - 0.12 12.3 6.1 0.22 11.5 4.2 1.4 1 1 0 1 1 1 0 Golgi transport complex subunit 5 DUF3452 PF11934.3 KII73771.1 - 0.12 11.7 0.3 0.18 11.1 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) DUF3086 PF11285.3 KII73771.1 - 0.12 11.1 0.8 0.18 10.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) WXG100 PF06013.7 KII73771.1 - 0.13 12.3 0.1 0.58 10.1 0.0 1.9 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DUF4140 PF13600.1 KII73771.1 - 0.14 12.5 0.4 0.19 12.1 0.3 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) CCDC-167 PF15188.1 KII73771.1 - 0.19 11.7 5.0 1.9 8.4 0.8 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Lzipper-MIP1 PF14389.1 KII73771.1 - 0.23 11.6 6.3 0.14 12.2 3.0 1.6 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 SidE PF12252.3 KII73771.1 - 0.23 8.7 4.0 0.29 8.4 2.8 1.0 1 0 0 1 1 1 0 Dot/Icm substrate protein Fzo_mitofusin PF04799.8 KII73771.1 - 0.25 10.7 2.0 0.32 10.3 1.3 1.3 1 1 0 1 1 1 0 fzo-like conserved region Syntaxin PF00804.20 KII73771.1 - 0.34 11.0 3.5 0.54 10.4 2.5 1.3 1 0 0 1 1 1 0 Syntaxin TBPIP PF07106.8 KII73771.1 - 0.78 9.2 6.5 1.3 8.5 4.5 1.5 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DivIVA PF05103.8 KII73771.1 - 0.87 9.6 4.8 2.9 7.9 3.2 1.9 1 1 0 1 1 1 0 DivIVA protein DUF2682 PF10909.3 KII73771.1 - 1.1 9.6 4.3 0.88 9.8 1.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2682) FlaC_arch PF05377.6 KII73771.1 - 1.2 9.0 5.2 0.48 10.3 0.8 2.3 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Serpin PF00079.15 KII73772.1 - 4.1e-26 91.9 0.8 9.1e-23 80.9 0.1 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) DDE_Tnp_IS1595 PF12762.2 KII73773.1 - 1.6e-21 76.7 0.0 2e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Toxin_ToxA PF11584.3 KII73774.1 - 0.091 12.6 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA SCIMP PF15050.1 KII73776.1 - 0.17 11.8 4.1 0.25 11.2 1.2 2.1 1 1 1 2 2 2 0 SCIMP protein DDE_Tnp_IS1595 PF12762.2 KII73777.1 - 1.9e-16 60.2 0.0 9.3e-09 35.2 0.0 2.7 2 1 0 2 2 2 2 ISXO2-like transposase domain ADAM_spacer1 PF05986.9 KII73780.1 - 0.086 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 ADAM-TS Spacer 1 Cnd3 PF12719.2 KII73781.1 - 0.0022 17.0 0.2 0.003 16.5 0.1 1.3 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain FANCI_S2 PF14676.1 KII73781.1 - 0.0082 16.0 0.5 0.011 15.7 0.3 1.2 1 0 0 1 1 1 1 FANCI solenoid 2 RRN3 PF05327.6 KII73781.1 - 0.017 13.2 0.0 0.02 13.0 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4042 PF13251.1 KII73781.1 - 0.029 13.8 0.2 0.046 13.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) DUF2435 PF10363.4 KII73781.1 - 0.073 12.9 0.1 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2435) Phage_Gp15 PF06854.6 KII73781.1 - 0.19 11.2 3.2 0.26 10.8 2.2 1.2 1 0 0 1 1 1 0 Bacteriophage Gp15 protein DIM1 PF02966.11 KII73784.1 - 3.4e-64 214.3 0.2 3.8e-64 214.1 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.15 KII73784.1 - 0.00043 19.9 0.1 0.00055 19.5 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 KII73784.1 - 0.0005 20.0 0.1 0.00092 19.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KII73784.1 - 0.012 15.7 0.3 0.016 15.4 0.2 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredox_DsbH PF03190.10 KII73784.1 - 0.029 14.1 0.2 0.047 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 ALS_ss_C PF10369.4 KII73784.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Small subunit of acetolactate synthase DDE_3 PF13358.1 KII73788.1 - 2e-10 40.5 0.1 1.7e-09 37.6 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 KII73788.1 - 0.011 14.5 0.0 0.016 13.9 0.0 1.3 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain CAML PF14963.1 KII73790.1 - 0.085 12.2 0.6 0.1 11.9 0.4 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand MMS22L_N PF14910.1 KII73791.1 - 0.043 12.0 0.1 0.048 11.9 0.0 1.0 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, N-terminal GutM PF06923.6 KII73791.1 - 0.079 12.6 0.4 4.7 6.9 0.1 2.1 1 1 1 2 2 2 0 Glucitol operon activator protein (GutM) UFC1 PF08694.6 KII73794.1 - 7.6e-68 227.0 0.1 8.2e-68 226.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.17 KII73794.1 - 0.014 15.3 0.2 0.022 14.6 0.1 1.4 1 1 0 1 1 1 0 RWD domain UQ_con PF00179.21 KII73794.1 - 0.034 13.5 0.2 0.041 13.3 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme DEAD PF00270.24 KII73795.1 - 2.2e-21 76.0 0.0 1.3e-20 73.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII73795.1 - 5.6e-20 70.9 0.0 1.6e-19 69.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII73795.1 - 1.3e-16 61.0 3.1 1.4e-16 60.8 0.0 2.6 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KII73795.1 - 0.063 13.4 0.0 0.34 11.0 0.0 2.2 1 1 0 1 1 1 0 AAA domain UPF0121 PF03661.8 KII73797.1 - 1.4e-31 109.6 10.9 1.6e-31 109.3 7.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Rad9_Rad53_bind PF08605.5 KII73797.1 - 0.15 11.8 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal Rad9-like Rad53-binding Seryl_tRNA_N PF02403.17 KII73800.1 - 0.013 15.4 2.2 0.013 15.4 1.5 1.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain IFT57 PF10498.4 KII73800.1 - 0.065 11.9 2.6 0.086 11.5 1.8 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Enkurin PF13864.1 KII73800.1 - 0.41 10.8 3.6 0.51 10.5 2.5 1.1 1 0 0 1 1 1 0 Calmodulin-binding DDE_3 PF13358.1 KII73801.1 - 1e-35 122.6 0.0 1.6e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII73801.1 - 3.5e-07 30.1 0.3 8.5e-06 25.7 0.1 2.4 2 0 0 2 2 2 1 Transposase rve PF00665.21 KII73801.1 - 1.4e-05 25.1 0.0 2.4e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_29 PF13551.1 KII73801.1 - 0.0015 18.6 0.0 0.0044 17.1 0.0 1.8 1 1 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII73801.1 - 0.0041 17.8 0.3 0.014 16.1 0.0 2.1 3 0 0 3 3 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII73801.1 - 0.0067 16.0 1.1 2.3 7.9 0.1 2.3 1 1 0 2 2 2 2 Transposase HTH_28 PF13518.1 KII73801.1 - 0.01 15.8 0.1 0.27 11.2 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.1 KII73801.1 - 0.013 15.0 1.6 0.43 10.3 0.0 3.1 3 0 0 3 3 3 0 Homeodomain-like domain HTH_33 PF13592.1 KII73801.1 - 0.015 14.8 0.0 0.038 13.5 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix DDE_1 PF03184.14 KII73801.1 - 0.018 14.1 0.0 0.31 10.1 0.0 2.5 2 1 1 3 3 3 0 DDE superfamily endonuclease Tn7_Tnp_TnsA_C PF08721.6 KII73801.1 - 0.02 14.8 0.8 0.92 9.5 0.0 3.0 3 0 0 3 3 3 0 TnsA endonuclease C terminal HTH_24 PF13412.1 KII73801.1 - 0.083 12.2 0.8 1.7 8.0 0.0 2.6 2 1 0 2 2 2 0 Winged helix-turn-helix DNA-binding Ribosomal_S6e PF01092.14 KII73805.1 - 1.7e-51 173.1 0.7 3.1e-51 172.3 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e EF-hand_4 PF12763.2 KII73806.1 - 1.2e-20 73.2 0.1 1.7e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 KII73806.1 - 7.6e-05 21.7 0.1 0.00018 20.5 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KII73806.1 - 0.0015 18.6 2.2 0.094 12.8 0.1 1.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KII73806.1 - 0.027 14.3 0.1 0.15 12.0 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.1 KII73806.1 - 0.05 12.9 0.2 0.1 11.9 0.1 1.4 1 0 0 1 1 1 0 EF hand GCD14 PF08704.5 KII73808.1 - 0.032 13.7 2.1 0.032 13.7 0.5 1.7 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit ING PF12998.2 KII73808.1 - 0.043 14.0 12.4 2.3 8.5 0.4 4.3 2 2 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Laminin_II PF06009.7 KII73808.1 - 0.73 9.5 8.9 0.15 11.8 0.2 3.4 2 1 1 3 3 3 0 Laminin Domain II Nup54 PF13874.1 KII73808.1 - 2.1 8.0 8.9 3.8 7.1 1.6 3.0 3 1 0 3 3 3 0 Nucleoporin complex subunit 54 Z1 PF10593.4 KII73808.1 - 4 6.5 12.4 8.7 5.4 3.8 2.5 2 1 0 2 2 2 0 Z1 domain DUF1068 PF06364.7 KII73808.1 - 5 6.6 7.2 7.4 6.1 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1068) zf-CCHC PF00098.18 KII73809.1 - 1.7e-05 24.5 1.7 3.7e-05 23.4 1.2 1.7 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.15 KII73809.1 - 0.0015 18.4 0.1 0.0054 16.6 0.0 1.9 2 1 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC_4 PF14392.1 KII73809.1 - 0.007 16.0 1.3 0.017 14.7 0.9 1.7 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.1 KII73809.1 - 0.014 15.1 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII73809.1 - 0.042 14.3 0.1 0.1 13.1 0.1 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.15 KII73810.1 - 0.044 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease PF09668.5 KII73810.1 - 0.069 12.7 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease rve PF00665.21 KII73811.1 - 8.8e-18 64.5 0.0 3.2e-17 62.7 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII73811.1 - 4.2e-14 52.4 0.0 1.2e-13 50.8 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII73811.1 - 0.00065 19.1 0.1 0.0014 18.0 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain DUF2305 PF10230.4 KII73811.1 - 0.075 12.4 2.4 4.6 6.5 0.1 2.7 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2305) SNAP PF14938.1 KII73812.1 - 0.003 16.7 0.0 0.003 16.7 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Phage_CII PF05269.6 KII73812.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage CII protein Monellin PF09200.5 KII73812.1 - 0.16 11.6 0.3 0.34 10.5 0.2 1.6 1 0 0 1 1 1 0 Monellin HSP20 PF00011.16 KII73814.1 - 1.4e-26 92.3 1.1 1.1e-16 60.5 0.1 2.1 2 0 0 2 2 2 2 Hsp20/alpha crystallin family DDE_3 PF13358.1 KII73817.1 - 7.6e-10 38.7 0.1 3e-07 30.2 0.0 2.6 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_23 PF13384.1 KII73817.1 - 7e-08 31.8 0.2 1.7e-07 30.6 0.1 1.6 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.13 KII73817.1 - 9.3e-06 25.3 0.4 1.6e-05 24.6 0.3 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_28 PF13518.1 KII73817.1 - 1.4e-05 25.0 0.3 3.2e-05 23.8 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.1 KII73817.1 - 3.3e-05 22.9 0.5 0.0001 21.3 0.3 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_38 PF13936.1 KII73817.1 - 0.00015 21.2 2.5 0.00039 19.8 1.7 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain ubiquitin PF00240.18 KII73817.1 - 0.00025 20.3 0.0 0.00065 19.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family HTH_Tnp_1 PF01527.15 KII73817.1 - 0.00056 19.8 0.2 0.001 18.9 0.1 1.4 1 0 0 1 1 1 1 Transposase CENP-B_N PF04218.8 KII73817.1 - 0.00061 19.1 0.2 0.0016 17.8 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Sigma70_r4_2 PF08281.7 KII73817.1 - 0.00089 18.6 1.1 0.15 11.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-70, region 4 Rad60-SLD PF11976.3 KII73817.1 - 0.0029 17.2 0.1 0.013 15.1 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like HTH_17 PF12728.2 KII73817.1 - 0.0053 16.9 0.1 0.015 15.5 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain DUF1323 PF07037.6 KII73817.1 - 0.0073 16.4 0.1 0.017 15.2 0.1 1.6 1 0 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_29 PF13551.1 KII73817.1 - 0.011 15.8 0.7 0.044 13.9 0.1 2.0 1 1 1 2 2 2 0 Winged helix-turn helix HTH_3 PF01381.17 KII73817.1 - 0.041 13.7 0.1 0.095 12.5 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix TrmB PF01978.14 KII73817.1 - 0.059 13.0 0.2 0.45 10.2 0.1 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB NUMOD1 PF07453.8 KII73817.1 - 0.085 12.7 0.0 1.6 8.7 0.0 2.6 2 0 0 2 2 2 0 NUMOD1 domain LacI PF00356.16 KII73817.1 - 0.13 11.9 2.8 5.6 6.6 0.0 3.1 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family Bot1p PF12298.3 KII73817.1 - 0.19 11.6 1.3 0.33 10.8 0.9 1.3 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein Sigma70_r4 PF04545.11 KII73817.1 - 0.81 9.0 4.1 0.43 9.9 0.5 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 Nuc_sug_transp PF04142.10 KII73818.1 - 3.7e-43 147.4 3.5 3.7e-43 147.4 2.5 1.5 2 0 0 2 2 2 1 Nucleotide-sugar transporter EamA PF00892.15 KII73818.1 - 6.7e-09 35.8 7.1 6.7e-09 35.8 4.9 2.0 2 1 0 2 2 2 1 EamA-like transporter family UAA PF08449.6 KII73818.1 - 4.6e-07 29.0 6.6 4.9e-07 28.9 4.1 1.3 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KII73818.1 - 7.7e-07 29.3 5.5 7.7e-07 29.3 3.8 2.2 2 1 0 2 2 2 1 Multidrug resistance efflux transporter TPT PF03151.11 KII73818.1 - 0.00034 20.2 13.3 0.002 17.7 8.4 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family ATPase_gene1 PF09527.5 KII73818.1 - 0.073 12.8 1.3 0.3 10.9 0.5 2.2 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit (ATPase_gene1) RNase_PH PF01138.16 KII73819.1 - 8.1e-11 42.3 0.0 1.3e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DoxX_3 PF13781.1 KII73821.1 - 0.017 15.4 0.1 0.023 15.0 0.1 1.1 1 0 0 1 1 1 0 DoxX-like family DUF3112 PF11309.3 KII73821.1 - 0.11 12.2 0.3 0.13 12.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) VCBS PF13517.1 KII73823.1 - 3e-10 40.2 13.1 6.9e-09 35.9 0.7 2.2 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII73823.1 - 1.2e-08 34.3 5.9 0.00084 18.9 2.5 2.5 2 0 0 2 2 2 2 FG-GAP repeat TcdB_toxin_midN PF12256.3 KII73823.1 - 0.021 14.3 0.1 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region BESS PF02944.15 KII73825.1 - 0.0028 17.1 0.0 0.0071 15.8 0.0 1.7 1 0 0 1 1 1 1 BESS motif DUF4473 PF14747.1 KII73826.1 - 0.13 12.5 0.0 0.39 10.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) RVT_1 PF00078.22 KII73830.1 - 1e-24 87.0 0.0 1.8e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII73830.1 - 6.4e-08 32.4 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII73830.1 - 0.0052 17.2 0.0 0.015 15.7 0.0 1.8 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KII73830.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DDE_3 PF13358.1 KII73831.1 - 1.6e-05 24.6 0.0 2.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease YGGT PF02325.12 KII73831.1 - 0.049 13.5 0.2 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 YGGT family rve PF00665.21 KII73832.1 - 0.036 14.1 0.1 0.047 13.8 0.1 1.1 1 0 0 1 1 1 0 Integrase core domain SOCS_box PF07525.11 KII73832.1 - 0.16 11.8 0.8 0.25 11.2 0.6 1.3 1 0 0 1 1 1 0 SOCS box Autophagy_Cterm PF10381.4 KII73833.1 - 1.1 8.4 6.0 0.22 10.6 1.1 2.2 2 0 0 2 2 2 0 Autophagocytosis associated protein C-terminal NSF PF02071.15 KII73836.1 - 0.0065 16.7 1.5 0.17 12.5 0.4 3.0 2 0 0 2 2 2 1 Aromatic-di-Alanine (AdAR) repeat SNAP PF14938.1 KII73836.1 - 0.013 14.6 0.1 0.02 14.0 0.0 1.3 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP YxiJ PF14176.1 KII73837.1 - 0.026 14.6 0.0 0.035 14.2 0.0 1.1 1 0 0 1 1 1 0 YxiJ-like protein DUF4064 PF13273.1 KII73838.1 - 0.028 14.5 0.0 0.037 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) bZIP_C PF12498.3 KII73839.1 - 0.072 14.3 1.5 0.8 10.9 0.0 2.1 1 1 1 2 2 2 0 Basic leucine-zipper C terminal hEGF PF12661.2 KII73841.1 - 0.78 9.9 5.0 1.6 8.9 3.4 1.6 1 0 0 1 1 1 0 Human growth factor-like EGF hEGF PF12661.2 KII73844.1 - 0.00075 19.4 14.0 0.048 13.7 0.7 2.6 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.8 KII73844.1 - 0.0091 16.1 14.4 0.0091 16.1 10.0 2.3 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.22 KII73844.1 - 0.031 14.2 11.8 0.031 14.2 8.2 2.4 2 1 0 2 2 2 0 EGF-like domain Senescence_reg PF04520.8 KII73846.1 - 0.0035 17.8 1.6 0.0049 17.3 1.1 1.2 1 0 0 1 1 1 1 Senescence regulator DUF2577 PF10844.3 KII73846.1 - 0.063 13.3 0.8 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2577) AA_synth PF06684.6 KII73846.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Amino acid synthesis GF_recep_IV PF14843.1 KII73846.1 - 0.21 11.2 2.7 0.33 10.5 1.9 1.3 1 0 0 1 1 1 0 Growth factor receptor domain IV DDE_1 PF03184.14 KII73848.1 - 5.1e-06 25.7 0.2 6.8e-06 25.3 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease EGF_2 PF07974.8 KII73849.1 - 0.021 15.0 15.8 0.021 15.0 10.9 2.4 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.2 KII73849.1 - 0.028 14.4 12.5 0.64 10.2 0.5 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.22 KII73849.1 - 1 9.3 14.4 0.49 10.4 7.6 2.2 2 0 0 2 2 2 0 EGF-like domain Senescence_reg PF04520.8 KII73850.1 - 0.05 14.0 1.7 0.068 13.6 1.2 1.3 1 0 0 1 1 1 0 Senescence regulator AA_synth PF06684.6 KII73850.1 - 0.086 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Amino acid synthesis DUF2577 PF10844.3 KII73851.1 - 0.0091 16.0 0.7 2.6 8.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2577) Senescence_reg PF04520.8 KII73851.1 - 0.15 12.5 9.1 0.39 11.2 6.3 1.8 1 1 0 1 1 1 0 Senescence regulator hEGF PF12661.2 KII73852.1 - 0.00075 19.4 14.0 0.048 13.7 0.7 2.6 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.8 KII73852.1 - 0.0091 16.1 14.4 0.0091 16.1 10.0 2.3 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.22 KII73852.1 - 0.031 14.2 11.8 0.031 14.2 8.2 2.4 2 1 0 2 2 2 0 EGF-like domain DDE_1 PF03184.14 KII73853.1 - 0.03 13.4 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Peptidase_C53 PF05550.6 KII73853.1 - 0.066 12.6 0.0 0.094 12.1 0.0 1.2 1 0 0 1 1 1 0 Pestivirus Npro endopeptidase C53 tRNA_lig_kinase PF08303.6 KII73854.1 - 0.04 13.8 1.8 1.8 8.4 0.6 2.2 2 0 0 2 2 2 0 tRNA ligase kinase domain DDE_3 PF13358.1 KII73855.1 - 9.4e-05 22.1 0.0 0.0015 18.2 0.0 1.9 1 1 0 2 2 2 1 DDE superfamily endonuclease DUF211 PF02680.9 KII73856.1 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 DUF2718 PF10918.3 KII73857.1 - 0.013 15.5 0.4 0.013 15.5 0.3 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2718) Senescence_reg PF04520.8 KII73857.1 - 0.65 10.4 2.8 1.5 9.3 2.0 1.5 1 1 0 1 1 1 0 Senescence regulator RNA_pol_A_bac PF01000.21 KII73860.1 - 6e-18 65.0 0.0 1.2e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 KII73860.1 - 3.7e-17 61.2 0.0 4.8e-17 60.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain CAP PF00188.21 KII73861.1 - 1.3e-24 87.0 0.0 1.3e-19 70.9 0.1 2.6 2 1 0 2 2 2 2 Cysteine-rich secretory protein family HSP20 PF00011.16 KII73862.1 - 3e-17 62.3 0.0 2.2e-11 43.5 0.0 2.0 1 1 1 2 2 2 2 Hsp20/alpha crystallin family TPT PF03151.11 KII73863.1 - 1.7e-12 47.2 13.6 1.7e-12 47.2 9.4 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family DDE_Tnp_IS1595 PF12762.2 KII73864.1 - 1.6e-11 44.2 0.1 2.2e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain RusA PF05866.6 KII73864.1 - 0.11 12.9 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Endodeoxyribonuclease RusA IMCp PF12314.3 KII73865.1 - 0.014 15.5 1.0 0.022 14.9 0.7 1.3 1 0 0 1 1 1 0 Inner membrane complex protein DDE_Tnp_IS1595 PF12762.2 KII73866.1 - 7.5e-09 35.5 1.8 1.1e-07 31.7 1.2 2.3 1 1 0 1 1 1 1 ISXO2-like transposase domain HTH_11 PF08279.7 KII73867.1 - 0.17 11.5 0.2 0.35 10.5 0.1 1.5 1 0 0 1 1 1 0 HTH domain GTP_EFTU PF00009.22 KII73869.1 - 3e-15 56.1 0.2 3.5e-15 55.9 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 KII73870.1 - 1.6e-05 24.9 0.7 2.4e-05 24.3 0.5 1.3 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 KII73870.1 - 0.052 13.3 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Elongation Factor G, domain II LepA_C PF06421.7 KII73871.1 - 8.5e-26 89.9 0.0 9.9e-26 89.7 0.0 1.1 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus Neuromodulin_N PF10580.4 KII73874.1 - 0.15 11.7 0.7 0.31 10.7 0.5 1.5 1 0 0 1 1 1 0 Gap junction protein N-terminal region rve PF00665.21 KII73876.1 - 2.8e-25 88.7 0.0 8.7e-25 87.1 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII73876.1 - 2.2e-18 66.4 0.0 2e-17 63.2 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII73876.1 - 2.3e-06 26.9 0.1 7.1e-06 25.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RICH PF05062.7 KII73876.1 - 0.15 12.2 3.7 0.6 10.2 1.0 2.6 2 0 0 2 2 2 0 RICH domain BrkDBD PF09607.5 KII73877.1 - 0.059 12.9 0.0 0.14 11.6 0.0 1.6 1 1 0 1 1 1 0 Brinker DNA-binding domain Xpo1 PF08389.7 KII73877.1 - 0.14 12.0 3.0 1.1 9.1 0.4 3.2 2 1 1 3 3 3 0 Exportin 1-like protein Hemerythrin PF01814.18 KII73879.1 - 8.6e-23 80.9 3.0 1.2e-22 80.5 2.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain ScdA_N PF04405.9 KII73879.1 - 4.5e-22 77.1 0.3 7.3e-22 76.5 0.2 1.3 1 0 0 1 1 1 1 Domain of Unknown function (DUF542) RRM_1 PF00076.17 KII73880.1 - 9.4e-34 114.8 5.3 5.6e-12 45.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII73880.1 - 6.6e-26 90.0 1.7 3.6e-09 36.4 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII73880.1 - 4e-20 71.3 0.1 1.3e-09 37.7 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KII73880.1 - 0.00027 20.6 0.3 0.063 13.0 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF4283 PF14111.1 KII73880.1 - 0.012 14.6 0.1 0.75 8.8 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4283) DUF1899 PF08953.6 KII73881.1 - 0.0071 15.9 0.1 0.11 12.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1899) PMG PF05287.7 KII73882.1 - 2.2 8.0 31.4 7.2 6.3 10.6 3.5 2 1 0 3 3 3 0 PMG protein DUF4317 PF14199.1 KII73883.1 - 0.0014 17.4 0.0 0.0031 16.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4317) HTH_28 PF13518.1 KII73886.1 - 0.047 13.7 0.0 0.12 12.4 0.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain DDE_Tnp_1_6 PF13751.1 KII73887.1 - 0.017 15.0 0.7 0.02 14.8 0.5 1.1 1 0 0 1 1 1 0 Transposase DDE domain Plasmod_Pvs28 PF06247.6 KII73887.1 - 0.02 14.4 0.2 0.025 14.1 0.1 1.1 1 0 0 1 1 1 0 Plasmodium ookinete surface protein Pvs28 TAT_ubiq PF07706.7 KII73887.1 - 0.099 12.5 0.5 0.18 11.7 0.3 1.4 1 0 0 1 1 1 0 Aminotransferase ubiquitination site DUF3896 PF13035.1 KII73887.1 - 0.16 12.0 0.6 0.27 11.3 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) rve PF00665.21 KII73888.1 - 3.4e-09 36.8 0.0 5.6e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII73888.1 - 0.0045 16.4 0.0 0.01 15.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_1 PF03184.14 KII73890.1 - 8.8e-07 28.2 0.0 1.3e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RNase_H_2 PF13482.1 KII73890.1 - 0.016 15.0 0.0 0.042 13.6 0.0 1.7 2 0 0 2 2 2 0 RNase_H superfamily C_tripleX PF02363.14 KII73893.1 - 0.11 12.6 2.9 0.11 12.6 2.0 3.1 3 1 0 3 3 3 0 Cysteine rich repeat SnAC PF14619.1 KII73894.1 - 0.072 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Snf2-ATP coupling, chromatin remodelling complex Anoctamin PF04547.7 KII73895.1 - 0.00049 18.8 2.8 0.001 17.8 1.9 1.4 1 0 0 1 1 1 1 Calcium-activated chloride channel Fer4_15 PF13459.1 KII73895.1 - 0.14 12.7 1.0 4.6 7.8 0.0 2.6 3 0 0 3 3 3 0 4Fe-4S single cluster domain Anoctamin PF04547.7 KII73896.1 - 0.00049 18.8 2.8 0.001 17.8 1.9 1.4 1 0 0 1 1 1 1 Calcium-activated chloride channel Fer4_15 PF13459.1 KII73896.1 - 0.14 12.7 1.0 4.6 7.8 0.0 2.6 3 0 0 3 3 3 0 4Fe-4S single cluster domain BNR PF02012.15 KII73900.1 - 0.022 14.5 1.3 1.5 8.9 0.4 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat AP_endonuc_2_N PF07582.7 KII73901.1 - 0.013 15.0 0.4 1.1 8.8 0.1 2.5 2 0 0 2 2 2 0 AP endonuclease family 2 C terminus DUF1974 PF09317.6 KII73901.1 - 0.12 11.7 0.3 0.32 10.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) AP_endonuc_2_N PF07582.7 KII73902.1 - 0.027 14.0 0.1 0.92 9.1 0.1 2.4 2 0 0 2 2 2 0 AP endonuclease family 2 C terminus Ldl_recept_a PF00057.13 KII73903.1 - 5.4e-25 87.0 64.1 3.9e-09 36.2 8.6 4.4 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A EMA PF02488.10 KII73904.1 - 0.05 13.0 0.7 0.068 12.6 0.5 1.3 1 1 0 1 1 1 0 Merozoite Antigen RRM_1 PF00076.17 KII73905.1 - 1.2e-46 156.1 1.0 1.8e-18 65.9 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII73905.1 - 2.5e-26 91.4 1.2 9.2e-12 44.7 0.1 4.4 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII73905.1 - 2.6e-22 78.4 1.7 3.2e-08 33.3 0.1 3.8 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII73905.1 - 0.0013 18.6 0.4 0.03 14.1 0.1 3.1 3 1 0 3 3 3 1 RNA binding motif Limkain-b1 PF11608.3 KII73905.1 - 0.067 12.9 0.1 15 5.4 0.0 3.3 3 0 0 3 3 3 0 Limkain b1 Nup35_RRM_2 PF14605.1 KII73905.1 - 0.079 12.7 0.1 3.9 7.3 0.0 2.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RVT_3 PF13456.1 KII73906.1 - 0.088 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like RVT_1 PF00078.22 KII73907.1 - 3.4e-16 59.2 0.0 3.3e-15 56.0 0.0 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cys_rich_FGFR PF00839.12 KII73907.1 - 0.018 14.9 1.1 0.65 9.9 0.1 2.5 2 0 0 2 2 2 0 Cysteine rich repeat RVT_1 PF00078.22 KII73908.1 - 8.8e-08 31.7 0.0 1.5e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MULE PF10551.4 KII73913.1 - 0.0068 16.5 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 MULE transposase domain DDE_3 PF13358.1 KII73914.1 - 0.00045 19.9 0.0 0.00052 19.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1184 PF06683.6 KII73915.1 - 0.13 11.9 0.6 0.14 11.7 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1184) RRM_1 PF00076.17 KII73916.1 - 4.1e-20 71.1 0.2 9.4e-20 70.0 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII73916.1 - 4e-13 49.1 0.1 9.1e-13 48.0 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII73916.1 - 1.6e-10 40.6 0.1 3.9e-10 39.4 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII73916.1 - 0.0024 17.7 0.1 0.0054 16.5 0.1 1.6 1 0 0 1 1 1 1 RNA binding motif Cnl2_NKP2 PF09447.5 KII73916.1 - 0.17 11.5 2.5 13 5.5 0.0 3.1 3 0 0 3 3 3 0 Cnl2/NKP2 family protein rve PF00665.21 KII73917.1 - 3.1e-10 40.1 0.0 8.4e-10 38.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain SLT_L PF14718.1 KII73917.1 - 0.0025 17.5 1.9 1 9.2 0.1 3.0 3 0 0 3 3 3 2 Soluble lytic murein transglycosylase L domain TRAPPC10 PF12584.3 KII73917.1 - 0.01 15.3 0.3 0.017 14.6 0.2 1.4 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 DUF1434 PF07254.7 KII73917.1 - 0.025 14.4 0.4 0.5 10.1 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1434) DDE_1 PF03184.14 KII73918.1 - 6.6e-07 28.6 0.0 1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Filamin PF00630.14 KII73918.1 - 0.0065 17.0 0.2 0.18 12.3 0.2 2.3 1 1 0 1 1 1 1 Filamin/ABP280 repeat VirDNA-topo-I_N PF09266.5 KII73918.1 - 0.048 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Viral DNA topoisomerase I, N-terminal RRM_1 PF00076.17 KII73920.1 - 9.8e-48 159.6 1.2 1.4e-19 69.5 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII73920.1 - 2.2e-26 91.6 1.3 7e-12 45.1 0.1 4.3 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII73920.1 - 1.3e-22 79.4 1.9 1.6e-08 34.2 0.1 3.8 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII73920.1 - 0.00028 20.6 0.3 0.0067 16.2 0.1 3.0 3 0 0 3 3 3 1 RNA binding motif Limkain-b1 PF11608.3 KII73920.1 - 0.0053 16.4 0.1 14 5.5 0.0 3.4 3 0 0 3 3 3 1 Limkain b1 Nup35_RRM_2 PF14605.1 KII73920.1 - 0.023 14.4 0.1 1 9.1 0.0 2.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Kelch_4 PF13418.1 KII73925.1 - 0.0016 18.1 0.0 0.54 10.0 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73925.1 - 0.0022 17.4 0.1 1.6 8.3 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 KII73925.1 - 0.0027 17.8 0.1 0.37 11.0 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII73926.1 - 5.5e-17 61.2 0.2 2.6e-05 23.9 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.1 KII73926.1 - 1.3e-16 59.9 2.9 1.8e-05 24.7 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII73926.1 - 1.3e-13 50.1 1.0 3.2e-05 23.3 0.0 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII73926.1 - 2.6e-12 46.5 0.1 0.00011 22.2 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII73926.1 - 2.4e-07 30.5 2.9 0.32 10.9 0.0 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KII73926.1 - 1.2e-06 28.0 2.0 0.0063 16.2 0.0 3.3 3 0 0 3 3 3 2 Kelch motif FBA_3 PF08268.7 KII73926.1 - 0.074 12.7 0.1 0.36 10.5 0.0 2.1 2 1 1 3 3 3 0 F-box associated domain rve PF00665.21 KII73929.1 - 1.7e-10 41.0 0.0 8e-10 38.8 0.0 2.0 1 1 1 2 2 2 1 Integrase core domain Ribosomal_S13_N PF08069.7 KII73930.1 - 7.6e-28 96.1 0.1 1.5e-27 95.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 KII73930.1 - 1.4e-23 82.4 0.3 2.3e-23 81.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 LicD PF04991.8 KII73933.1 - 1.8e-12 47.7 0.2 1.6e-10 41.4 0.1 2.1 1 1 0 1 1 1 1 LicD family RhoGEF PF00621.15 KII73934.1 - 2.8e-35 121.8 8.0 6.5e-35 120.6 5.5 1.7 1 0 0 1 1 1 1 RhoGEF domain BRCT PF00533.21 KII73934.1 - 4.1e-13 49.2 0.1 3.2e-05 23.9 0.0 3.4 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KII73934.1 - 4.7e-12 45.5 0.0 2.9e-07 30.2 0.0 3.0 2 0 0 2 2 2 2 twin BRCT domain WD40 PF00400.27 KII73935.1 - 2.7e-05 23.8 1.4 0.021 14.6 1.1 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat LisH PF08513.6 KII73936.1 - 8.9e-06 25.2 0.4 2.6e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 LisH FHIPEP PF00771.15 KII73936.1 - 0.13 10.6 0.0 0.16 10.2 0.0 1.1 1 0 0 1 1 1 0 FHIPEP family CSD PF00313.17 KII73937.1 - 2.1e-18 65.8 0.0 3.3e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 KII73937.1 - 0.00028 20.3 0.1 0.011 15.2 0.0 2.8 2 1 0 2 2 2 1 Ribonuclease B OB domain Ribosomal_L29e PF01779.12 KII73937.1 - 0.00039 20.2 0.1 0.0026 17.5 0.1 2.4 2 0 0 2 2 2 1 Ribosomal L29e protein family SRP-alpha_N PF04086.8 KII73937.1 - 0.067 12.5 5.9 0.11 11.8 4.1 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MSP1a PF11670.3 KII73938.1 - 0.04 13.7 2.4 0.077 12.8 1.7 1.4 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) DUF87 PF01935.12 KII73938.1 - 0.066 13.0 0.1 0.094 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 Colicin-DNase PF12639.2 KII73938.1 - 0.097 12.9 0.1 0.22 11.7 0.0 1.5 1 1 0 1 1 1 0 DNase/tRNase domain of colicin-like bacteriocin MDMPI_C PF07398.6 KII73938.1 - 0.11 13.0 0.0 0.22 12.1 0.0 1.5 1 1 0 1 1 1 0 MDMPI C-terminal domain LIM PF00412.17 KII73941.1 - 2.9e-23 81.6 54.3 1.2e-09 38.0 9.5 3.3 3 0 0 3 3 3 3 LIM domain PDZ PF00595.19 KII73941.1 - 1.5e-11 44.3 0.3 2.9e-11 43.3 0.2 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII73941.1 - 9e-07 28.7 0.1 1.8e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 PDZ domain Tetraspannin PF00335.15 KII73942.1 - 4.3e-15 55.5 11.4 5.6e-15 55.2 7.9 1.1 1 0 0 1 1 1 1 Tetraspanin family DDE_1 PF03184.14 KII73943.1 - 1.7e-10 40.4 0.0 2.8e-10 39.6 0.0 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease Prominin PF05478.6 KII73943.1 - 0.05 11.1 0.3 0.058 10.9 0.2 1.0 1 0 0 1 1 1 0 Prominin HTH_Tnp_Tc5 PF03221.11 KII73943.1 - 0.092 12.5 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain Dynein_heavy PF03028.10 KII73945.1 - 0.018 13.0 0.5 0.028 12.4 0.3 1.2 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor Acp26Ab PF05777.7 KII73947.1 - 0.073 13.5 0.8 0.12 12.8 0.1 1.8 2 1 0 2 2 2 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) Phage_P2_GpU PF06995.6 KII73948.1 - 2.4e-43 146.3 0.1 3e-43 146.0 0.1 1.1 1 0 0 1 1 1 1 Phage P2 GpU SIR2_2 PF13289.1 KII73949.1 - 3.9e-13 49.4 1.7 1.2e-12 47.8 0.3 2.6 3 0 0 3 3 3 1 SIR2-like domain AAA_10 PF12846.2 KII73949.1 - 0.019 14.4 0.1 0.063 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain AAA_22 PF13401.1 KII73949.1 - 0.02 15.0 0.1 0.099 12.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 KII73949.1 - 0.041 13.2 0.0 0.095 12.1 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Serpin PF00079.15 KII73951.1 - 2.8e-17 62.9 0.5 3.1e-17 62.7 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73952.1 - 8.6e-13 48.1 1.2 1e-12 47.9 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) MOZART1 PF12554.3 KII73952.1 - 0.026 13.9 0.5 1.8 8.0 0.0 3.0 4 0 0 4 4 4 0 Mitotic-spindle organizing gamma-tubulin ring associated DUF1106 PF06523.6 KII73953.1 - 0.015 15.0 0.1 0.025 14.4 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1106) Serpin PF00079.15 KII73954.1 - 5.8e-49 167.1 1.3 6.6e-49 167.0 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73955.1 - 8e-14 51.5 3.4 9.6e-14 51.2 2.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII73956.1 - 6.4e-43 147.3 1.1 7.3e-43 147.1 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4413 PF14372.1 KII73956.1 - 0.05 13.5 1.2 7.1 6.6 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) ATP-synt_C PF00137.16 KII73957.1 - 2.3e-16 59.4 14.1 3.3e-16 58.9 9.7 1.2 1 0 0 1 1 1 1 ATP synthase subunit C DUF3487 PF11990.3 KII73957.1 - 8.1 5.8 6.1 5.4 6.4 2.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3487) DUF1049 PF06305.6 KII73958.1 - 0.032 13.7 0.1 0.074 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Orthoreo_P10 PF07204.6 KII73958.1 - 0.097 12.4 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 SecY PF00344.15 KII73959.1 - 1.1e-28 100.1 0.2 1.3e-28 100.0 0.2 1.0 1 0 0 1 1 1 1 SecY translocase SecY PF00344.15 KII73960.1 - 1.5e-40 139.1 9.4 1.8e-40 138.9 6.5 1.0 1 0 0 1 1 1 1 SecY translocase ODV-E18 PF10717.4 KII73960.1 - 0.034 13.5 0.7 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 TMEM154 PF15102.1 KII73961.1 - 0.1 12.2 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF1652 PF07865.6 KII73962.1 - 0.01 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1652) ATP_synt_I PF03899.10 KII73963.1 - 2.8 8.1 7.6 10 6.3 5.2 1.9 1 1 0 1 1 1 0 ATP synthase I chain RNA_pol_I_A49 PF06870.7 KII73964.1 - 1.2e-21 76.7 0.1 1.5e-21 76.4 0.1 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor GTP_EFTU PF00009.22 KII73966.1 - 7.8e-27 93.9 0.0 7.8e-27 93.9 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 KII73966.1 - 1.1e-18 67.0 0.0 2.7e-18 65.8 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 KII73966.1 - 6e-10 39.0 1.0 0.00013 22.0 0.0 3.0 2 0 0 2 2 2 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 KII73966.1 - 1.9e-07 30.6 0.1 4.9e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 KII73966.1 - 1.2e-06 28.4 0.1 4.7e-06 26.5 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KII73966.1 - 0.0035 16.6 1.4 0.15 11.3 1.0 2.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_22 PF13401.1 KII73966.1 - 0.0088 16.1 0.1 0.063 13.4 0.1 2.4 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.12 KII73966.1 - 0.011 15.2 0.3 0.042 13.3 0.0 2.1 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.4 KII73966.1 - 0.04 13.3 0.4 7.3 6.0 0.1 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation TMCO5 PF14992.1 KII73966.1 - 0.06 12.4 15.8 0.11 11.6 10.9 1.4 1 0 0 1 1 1 0 TMCO5 family DUF1423 PF07227.6 KII73966.1 - 2.1 6.8 17.4 3.7 6.1 12.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) Neur_chan_memb PF02932.11 KII73966.1 - 4.5 7.0 6.7 8.2 6.2 4.6 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region WD40 PF00400.27 KII73968.1 - 7.7e-23 79.4 18.7 1.5e-08 34.1 0.5 6.3 6 1 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 KII73968.1 - 2.1e-10 40.6 0.1 9e-06 25.5 0.1 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KII73968.1 - 0.0016 17.6 0.2 0.085 11.9 0.0 2.3 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal RAB3GAP2_N PF14655.1 KII73968.1 - 0.019 14.0 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TFIIIC_delta PF12657.2 KII73968.1 - 0.026 14.2 0.5 0.2 11.3 0.3 2.7 1 1 0 1 1 1 0 Transcription factor IIIC subunit delta N-term FTCD_C PF04961.7 KII73970.1 - 0.15 11.4 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Spermine_synth PF01564.12 KII73972.1 - 2e-58 197.2 1.4 2.1e-53 180.7 0.1 2.1 1 1 1 2 2 2 2 Spermine/spermidine synthase Methyltransf_31 PF13847.1 KII73972.1 - 0.00022 20.8 0.0 0.00033 20.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KII73972.1 - 0.002 18.1 0.0 0.0033 17.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KII73972.1 - 0.032 13.6 0.1 0.097 12.0 0.1 1.7 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW Methyltransf_30 PF05430.6 KII73972.1 - 0.066 12.8 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase UPF0278 PF08745.6 KII73973.1 - 0.013 14.7 0.2 0.016 14.4 0.1 1.2 1 0 0 1 1 1 0 UPF0278 family DUF2067 PF09840.4 KII73973.1 - 0.028 13.9 0.1 0.041 13.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) Methyltransf_15 PF09445.5 KII73973.1 - 0.14 11.6 0.9 0.33 10.4 0.6 1.7 1 1 1 2 2 2 0 RNA cap guanine-N2 methyltransferase DUF1759 PF03564.10 KII73974.1 - 0.0058 16.4 2.9 0.0086 15.8 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) GP41 PF00517.12 KII73974.1 - 0.025 14.1 1.3 0.045 13.3 0.9 1.4 1 0 0 1 1 1 0 Retroviral envelope protein DUF4449 PF14613.1 KII73974.1 - 0.077 12.9 0.8 0.13 12.1 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) Ribonuclease_T2 PF00445.13 KII73974.1 - 0.49 9.9 3.0 0.28 10.7 0.4 1.7 2 0 0 2 2 2 0 Ribonuclease T2 family Synaptobrevin PF00957.16 KII73974.1 - 3 7.5 11.9 53 3.5 8.2 2.4 1 1 0 1 1 1 0 Synaptobrevin DUF912 PF06024.7 KII73974.1 - 4.2 7.4 6.9 2.3 8.3 2.7 2.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MASE1 PF05231.9 KII73975.1 - 0.086 11.8 1.3 0.1 11.6 0.9 1.1 1 0 0 1 1 1 0 MASE1 Herpes_DNAp_acc PF04929.7 KII73975.1 - 0.72 8.7 4.6 0.87 8.4 3.2 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF2427 PF10348.4 KII73975.1 - 0.91 9.1 7.6 0.22 11.1 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) Kelch_6 PF13964.1 KII73976.1 - 5.7e-23 80.0 20.4 5.6e-05 23.1 0.1 6.2 5 1 1 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII73976.1 - 1.1e-17 63.5 15.5 0.00033 20.3 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KII73976.1 - 1.4e-15 56.9 12.7 0.00062 19.8 0.0 6.9 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73976.1 - 2.2e-09 36.7 27.0 0.00095 18.6 1.1 7.0 7 1 0 7 7 7 4 Kelch motif Kelch_2 PF07646.10 KII73976.1 - 5.8e-05 22.6 16.0 0.015 15.0 0.2 6.0 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.1 KII73976.1 - 0.00037 20.3 9.6 0.15 12.0 0.0 4.9 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 KII73977.1 - 0.0013 18.7 0.0 1.2 9.4 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 KII73977.1 - 0.002 17.8 0.4 0.69 9.7 0.1 2.8 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII73977.1 - 0.016 15.3 0.1 0.89 9.8 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_3 PF13415.1 KII73978.1 - 0.00031 20.7 0.1 0.0046 17.0 0.0 2.4 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KII73978.1 - 0.00054 19.6 1.7 0.013 15.2 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 KII73978.1 - 0.0013 18.7 1.0 0.017 15.2 0.0 2.3 1 1 1 2 2 2 1 Kelch motif Kelch_1 PF01344.20 KII73978.1 - 0.036 13.6 3.4 0.064 12.8 0.1 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.1 KII73978.1 - 0.24 11.3 0.9 15 5.6 0.2 2.6 3 0 0 3 3 3 0 Kelch motif Homeobox PF00046.24 KII73979.1 - 4.8e-18 64.5 4.2 4.8e-18 64.5 2.9 1.8 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 KII73979.1 - 0.0011 18.6 0.1 0.0027 17.3 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Kelch_6 PF13964.1 KII73980.1 - 9.9e-16 57.1 18.9 9.4e-05 22.4 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KII73980.1 - 6.5e-11 41.8 18.5 0.048 13.4 0.4 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 KII73980.1 - 3.2e-09 36.7 14.3 0.14 12.3 0.1 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73980.1 - 0.00043 19.7 27.5 0.011 15.3 1.8 6.7 6 1 0 6 6 6 2 Kelch motif Kelch_5 PF13854.1 KII73980.1 - 0.0031 17.4 7.0 0.043 13.7 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.10 KII73980.1 - 0.0045 16.6 12.0 0.038 13.7 0.1 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.1 KII73981.1 - 1.3e-15 56.8 5.3 0.0015 18.5 0.0 4.2 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.1 KII73981.1 - 1.5e-09 37.7 2.5 0.03 14.5 0.0 4.2 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII73981.1 - 1.8e-09 37.2 12.0 0.11 12.2 0.1 5.3 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73981.1 - 4.3e-05 22.9 8.1 0.42 10.2 0.0 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 KII73981.1 - 0.0034 17.0 2.2 0.08 12.7 0.0 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.1 KII73982.1 - 1.3e-15 56.9 6.7 0.0023 17.6 0.0 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KII73982.1 - 1.3e-15 56.7 9.5 0.0024 17.9 0.1 6.4 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.1 KII73982.1 - 1e-13 51.0 1.6 0.036 14.2 0.0 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII73982.1 - 8.6e-09 34.8 12.8 0.00059 19.3 0.2 5.3 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 KII73982.1 - 1.1e-06 28.1 7.1 0.11 12.2 0.2 6.0 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.1 KII73982.1 - 0.042 13.8 7.1 0.046 13.7 0.0 4.0 6 0 0 6 6 6 0 Kelch motif RVP PF00077.15 KII73983.1 - 7e-06 25.8 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII73983.1 - 2.2e-05 24.8 0.0 8.4e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KII73983.1 - 3.8e-05 23.4 0.0 8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.18 KII73983.1 - 9.8e-05 22.1 0.9 9.8e-05 22.1 0.6 3.0 2 1 0 2 2 2 1 Zinc knuckle Asp_protease PF09668.5 KII73983.1 - 0.0094 15.5 0.0 0.029 13.9 0.0 1.8 1 1 0 1 1 1 1 Aspartyl protease rve PF00665.21 KII73984.1 - 4.7e-09 36.3 0.0 7.7e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain ING PF12998.2 KII73987.1 - 0.032 14.4 1.6 7.3 6.9 0.1 2.3 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Spc24 PF08286.6 KII73987.1 - 0.049 13.3 0.7 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF150 PF02576.12 KII73987.1 - 0.058 12.9 0.1 0.097 12.2 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised BCR, YhbC family COG0779 Col_cuticle_N PF01484.12 KII73987.1 - 0.14 11.8 0.1 0.44 10.2 0.1 1.8 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain RVT_1 PF00078.22 KII73988.1 - 0.0085 15.4 0.1 0.01 15.1 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) T4_Gp59_C PF08994.5 KII73988.1 - 0.015 15.4 0.2 0.021 14.9 0.1 1.4 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term Integrin_beta PF00362.13 KII73989.1 - 5.6e-09 35.4 0.0 8.7e-09 34.7 0.0 1.2 1 0 0 1 1 1 1 Integrin, beta chain PSI PF01437.20 KII73989.1 - 0.17 12.0 0.8 0.32 11.2 0.6 1.4 1 1 0 1 1 1 0 Plexin repeat EGF_2 PF07974.8 KII73990.1 - 2e-06 27.8 46.4 0.00051 20.1 10.9 3.7 3 1 0 3 3 3 2 EGF-like domain hEGF PF12661.2 KII73990.1 - 0.0018 18.2 3.2 0.0018 18.2 2.3 5.0 5 0 0 5 5 5 1 Human growth factor-like EGF ETRAMP PF09716.5 KII73991.1 - 0.0011 18.8 0.1 0.0014 18.5 0.1 1.3 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) CD34_antigen PF06365.7 KII73991.1 - 0.11 12.1 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Glycos_transf_2 PF00535.21 KII73994.1 - 0.00038 20.1 0.0 0.00063 19.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Colicin_D PF11429.3 KII73994.1 - 0.063 13.4 1.4 0.13 12.4 0.3 2.0 1 1 1 2 2 2 0 Colicin D AKNA PF12443.3 KII73995.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 AT-hook-containing transcription factor GTP_EFTU PF00009.22 KII73996.1 - 1.7e-58 197.1 0.0 2.4e-58 196.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 KII73996.1 - 3.4e-33 113.7 0.0 9.4e-33 112.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 KII73996.1 - 1.1e-17 63.7 0.0 2.5e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 KII73996.1 - 9.1e-14 51.0 0.0 2e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 KII73996.1 - 1.7e-07 31.2 0.0 5.3e-07 29.6 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MBOAT PF03062.14 KII73997.1 - 4.3e-18 65.5 18.1 5.4e-18 65.1 12.5 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 KII73997.1 - 3e-06 27.2 7.3 5.8e-06 26.2 5.1 1.4 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Mitofilin PF09731.4 KII73998.1 - 1.6e-08 33.7 31.9 1.5e-06 27.2 21.7 3.0 1 1 0 1 1 1 1 Mitochondrial inner membrane protein DUF4547 PF15080.1 KII73998.1 - 0.16 11.4 6.4 0.11 11.9 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4547) DNA_repr_REX1B PF14966.1 KII73998.1 - 5.1 7.5 9.5 3.4 8.1 0.0 3.8 4 1 1 5 5 5 0 DNA repair REX1-B RRM_1 PF00076.17 KII73999.1 - 1.1e-14 53.8 0.0 1.8e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII73999.1 - 4.6e-11 42.5 0.0 7.5e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII73999.1 - 9.9e-07 28.5 0.1 1.7e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KII73999.1 - 0.00089 19.0 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 RNA binding motif RabGAP-TBC PF00566.13 KII74002.1 - 2.7e-09 36.8 2.3 3.5e-07 29.9 1.6 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain zf-RanBP PF00641.13 KII74003.1 - 6e-07 28.4 5.7 8e-07 28.0 4.0 1.2 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Ribosomal_L21e PF01157.13 KII74005.1 - 1.8e-36 123.9 9.6 2.9e-36 123.2 6.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e NPV_P10 PF05531.7 KII74006.1 - 0.44 10.8 2.7 0.34 11.1 0.5 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Peptidase_C1 PF00112.18 KII74007.1 - 7.6e-35 120.7 0.7 8.8e-35 120.5 0.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1 PF00112.18 KII74008.1 - 6e-38 130.9 2.3 7.6e-38 130.5 1.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease FAM60A PF15396.1 KII74009.1 - 1.9e-06 27.7 0.2 4.8e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Protein Family FAM60A Cache_2 PF08269.6 KII74009.1 - 0.11 12.4 0.5 0.27 11.2 0.4 1.6 1 0 0 1 1 1 0 Cache domain AT_hook PF02178.14 KII74009.1 - 0.33 10.7 6.5 0.078 12.6 2.2 1.8 2 0 0 2 2 2 0 AT hook motif Mo25 PF08569.6 KII74011.1 - 1.4e-33 116.3 0.1 1.6e-33 116.1 0.1 1.0 1 0 0 1 1 1 1 Mo25-like Flagellin_N PF00669.15 KII74011.1 - 0.034 13.9 1.5 0.052 13.3 1.0 1.2 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region Clathrin_lg_ch PF01086.12 KII74011.1 - 0.097 12.5 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Clathrin light chain Zip PF02535.17 KII74018.1 - 0.4 9.6 1.9 0.48 9.3 1.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Aminotran_1_2 PF00155.16 KII74020.1 - 3.5e-14 52.5 0.0 3.8e-14 52.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_1_2 PF00155.16 KII74022.1 - 8.1e-25 87.5 0.0 1.3e-24 86.9 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II DUF21 PF01595.15 KII74023.1 - 1.7e-30 105.6 11.3 2.3e-30 105.2 7.8 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF21 RVT_1 PF00078.22 KII74024.1 - 2.8e-15 56.2 0.1 1.1e-14 54.3 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII74024.1 - 1.7e-07 31.0 0.2 3.9e-07 29.9 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII74024.1 - 2.3e-06 27.9 0.0 5.6e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII74024.1 - 6.6e-06 25.8 0.0 1.6e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII74024.1 - 0.0026 17.6 0.0 0.0058 16.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII74024.1 - 0.018 14.6 0.0 0.046 13.2 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.1 KII74024.1 - 0.053 13.0 3.9 0.14 11.7 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Pkinase PF00069.20 KII74027.1 - 4.4e-64 216.1 0.1 5.6e-64 215.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII74027.1 - 3e-30 105.1 0.0 4.7e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KII74027.1 - 0.00015 20.8 0.1 0.00025 20.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KII74027.1 - 0.00062 18.8 0.0 0.00088 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KII74027.1 - 0.0043 16.8 0.0 0.0053 16.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 KII74027.1 - 0.011 14.5 0.2 0.018 13.8 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 YrbL-PhoP_reg PF10707.4 KII74027.1 - 0.021 14.1 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.17 KII74027.1 - 0.03 13.6 0.3 0.044 13.1 0.2 1.2 1 0 0 1 1 1 0 RIO1 family ORC4_C PF14629.1 KII74028.1 - 7.8e-06 25.4 1.1 1e-05 25.0 0.8 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus RF-1 PF00472.15 KII74030.1 - 2.7e-06 27.1 0.0 1.2e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 RF-1 domain MULE PF10551.4 KII74031.1 - 2.5e-08 33.9 0.1 1.3e-07 31.6 0.0 2.2 2 0 0 2 2 2 1 MULE transposase domain DUF2347 PF09804.4 KII74031.1 - 0.046 13.0 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DDE_Tnp_ISL3 PF01610.12 KII74031.1 - 0.074 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Transposase DUF2423 PF10338.4 KII74032.1 - 0.016 15.1 6.7 0.016 15.1 4.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2423) DDE_Tnp_IS1595 PF12762.2 KII74033.1 - 4.7e-07 29.7 0.0 9.5e-07 28.7 0.0 1.5 1 1 0 2 2 2 1 ISXO2-like transposase domain Fumarate_red_C PF02300.12 KII74033.1 - 0.031 14.1 0.1 0.23 11.3 0.1 2.0 1 1 0 1 1 1 0 Fumarate reductase subunit C DUF1841 PF08897.6 KII74037.1 - 0.07 12.9 0.1 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1841) DUF2040 PF09745.4 KII74038.1 - 4.2e-26 91.2 11.2 6.2e-26 90.7 7.7 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 55 (DUF2040) WD40 PF00400.27 KII74039.1 - 0.00015 21.5 0.1 0.067 13.1 0.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF4221 PF13970.1 KII74039.1 - 0.12 11.7 1.5 0.24 10.7 0.6 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4221) RBD-FIP PF09457.5 KII74040.1 - 3.1e-06 26.8 2.1 4.6e-06 26.3 1.5 1.2 1 0 0 1 1 1 1 FIP domain TFIIS_M PF07500.9 KII74041.1 - 0.02 14.9 1.1 0.032 14.2 0.7 1.3 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain DUF2408 PF10303.4 KII74041.1 - 0.056 13.5 0.2 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) BAR PF03114.13 KII74042.1 - 2.8e-09 36.8 0.0 3.4e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.4 KII74042.1 - 0.0046 15.9 0.1 0.0058 15.5 0.1 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Rabaptin PF03528.10 KII74042.1 - 0.019 14.8 0.2 0.095 12.6 0.1 1.9 2 0 0 2 2 2 0 Rabaptin Cep57_MT_bd PF06657.8 KII74042.1 - 0.07 13.0 0.9 4.3 7.3 0.0 2.9 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 DUF4349 PF14257.1 KII74042.1 - 0.13 11.5 1.3 0.22 10.7 0.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) ATP_bind_3 PF01171.15 KII74043.1 - 0.00011 21.7 0.0 0.0002 20.8 0.0 1.4 1 0 0 1 1 1 1 PP-loop family PAPS_reduct PF01507.14 KII74043.1 - 0.0024 17.7 0.0 0.004 16.9 0.0 1.5 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family AAA_15 PF13175.1 KII74043.1 - 0.0058 15.7 0.3 0.0064 15.5 0.2 1.2 1 0 0 1 1 1 1 AAA ATPase domain PC_rep PF01851.17 KII74043.1 - 0.082 13.1 0.0 0.3 11.4 0.0 2.0 2 0 0 2 2 2 0 Proteasome/cyclosome repeat FixQ PF05545.6 KII74044.1 - 0.0087 15.6 2.4 0.016 14.8 0.0 2.0 2 0 0 2 2 2 1 Cbb3-type cytochrome oxidase component FixQ SdpI PF13630.1 KII74044.1 - 4.9 6.9 6.3 7.2 6.3 4.3 1.2 1 0 0 1 1 1 0 SdpI/YhfL protein family RPEL PF02755.10 KII74045.1 - 0.00027 20.1 0.8 0.0026 17.0 0.7 2.2 2 0 0 2 2 2 1 RPEL repeat DDE_Tnp_IS1595 PF12762.2 KII74046.1 - 5.9e-08 32.6 0.2 1.3e-06 28.3 0.2 2.1 1 1 0 1 1 1 1 ISXO2-like transposase domain S1 PF00575.18 KII74047.1 - 9.8e-28 96.0 12.2 3.2e-09 36.7 0.0 7.3 9 0 0 9 9 9 5 S1 RNA binding domain EXOSC1 PF10447.4 KII74047.1 - 0.0005 19.9 0.3 1.4 8.9 0.0 4.1 4 0 0 4 4 4 2 Exosome component EXOSC1/CSL4 TPR_14 PF13428.1 KII74047.1 - 0.0011 19.3 0.0 20 6.1 0.1 3.9 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 KII74047.1 - 0.0041 17.4 0.0 0.11 12.7 0.0 2.6 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 KII74047.1 - 0.12 12.3 0.8 0.78 9.7 0.5 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat ubiquitin PF00240.18 KII74048.1 - 8.1e-68 223.7 6.1 2.1e-33 113.4 0.4 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 KII74048.1 - 4.6e-41 138.3 5.1 8.2e-20 70.2 0.3 2.3 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 KII74048.1 - 6.6e-12 45.5 1.1 0.00026 21.2 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Telomere_Sde2 PF13019.1 KII74048.1 - 9.8e-10 38.3 0.1 0.0011 18.7 0.0 2.1 2 0 0 2 2 2 2 Telomere stability and silencing Rad60-SLD_2 PF13881.1 KII74048.1 - 1.5e-07 31.2 0.3 0.028 14.2 0.0 2.7 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 KII74048.1 - 2.6e-05 24.3 0.1 0.26 11.5 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain DUF2870 PF11069.3 KII74048.1 - 5.4e-05 23.1 0.0 0.5 10.4 0.0 2.8 4 0 0 4 4 2 2 Protein of unknown function (DUF2870) TUG-UBL1 PF11470.3 KII74048.1 - 8.9e-05 22.3 0.5 0.45 10.4 0.0 2.2 2 0 0 2 2 2 2 GLUT4 regulating protein TUG eRF1_1 PF03463.10 KII74048.1 - 0.00018 21.0 0.2 0.51 9.9 0.0 3.0 1 1 2 3 3 3 2 eRF1 domain 1 USP7_C2 PF14533.1 KII74048.1 - 0.0033 16.8 0.2 2.2 7.6 0.0 2.2 1 1 0 2 2 2 2 Ubiquitin-specific protease C-terminal PI3K_rbd PF00794.13 KII74048.1 - 0.0068 16.3 0.8 5 7.1 0.1 2.6 2 1 0 2 2 2 2 PI3-kinase family, ras-binding domain CTDII PF01556.13 KII74048.1 - 0.063 13.1 3.2 1.8 8.5 0.2 2.3 1 1 1 2 2 2 0 DnaJ C terminal domain IGR PF09597.5 KII74048.1 - 0.089 12.7 0.0 21 5.1 0.0 2.4 2 0 0 2 2 2 0 IGR protein motif GABP-alpha PF11620.3 KII74048.1 - 0.11 12.5 0.4 17 5.4 0.0 2.1 2 0 0 2 2 2 0 GA-binding protein alpha chain YfmQ PF10787.4 KII74048.1 - 0.11 11.8 0.1 14 5.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein from bacillus cereus group YajC PF02699.10 KII74048.1 - 0.15 11.7 1.0 6.9 6.4 0.0 2.2 2 0 0 2 2 2 0 Preprotein translocase subunit ubiquitin PF00240.18 KII74049.1 - 6.1e-169 547.7 33.3 8.4e-33 111.5 0.4 6.0 6 0 0 6 6 6 6 Ubiquitin family Rad60-SLD PF11976.3 KII74049.1 - 4.1e-102 333.9 29.3 2.5e-19 68.7 0.5 6.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 KII74049.1 - 1e-27 96.2 10.8 0.00094 19.3 0.1 6.9 5 5 0 5 5 5 5 Ubiquitin-like domain Telomere_Sde2 PF13019.1 KII74049.1 - 5.5e-24 84.6 1.6 0.0038 16.9 0.0 5.5 5 1 1 6 6 6 5 Telomere stability and silencing Rad60-SLD_2 PF13881.1 KII74049.1 - 9.6e-18 64.1 4.6 0.11 12.4 0.0 6.0 5 4 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 KII74049.1 - 2e-13 50.3 2.5 0.88 9.7 0.0 5.2 1 1 3 5 5 5 5 DUF2407 ubiquitin-like domain DUF2870 PF11069.3 KII74049.1 - 7.3e-13 48.3 0.0 2.3 8.3 0.0 5.9 5 0 0 5 5 5 5 Protein of unknown function (DUF2870) eRF1_1 PF03463.10 KII74049.1 - 2.4e-11 43.3 9.1 1.8 8.1 0.0 7.1 1 1 1 6 6 6 5 eRF1 domain 1 TUG-UBL1 PF11470.3 KII74049.1 - 1.2e-08 34.7 12.4 1.5 8.7 0.0 5.5 6 0 0 6 6 5 4 GLUT4 regulating protein TUG PI3K_rbd PF00794.13 KII74049.1 - 1.4e-08 34.5 5.4 12 5.9 0.0 6.4 6 0 0 6 6 6 0 PI3-kinase family, ras-binding domain USP7_C2 PF14533.1 KII74049.1 - 2.7e-07 30.2 6.1 6.7 6.0 0.0 5.1 1 1 1 5 5 5 1 Ubiquitin-specific protease C-terminal IGR PF09597.5 KII74049.1 - 6.6e-06 25.9 0.0 57 3.7 0.0 5.3 5 0 0 5 5 5 0 IGR protein motif EMG1 PF03587.9 KII74049.1 - 1.3e-05 24.5 4.5 23 4.2 0.0 5.7 6 0 0 6 6 6 0 EMG1/NEP1 methyltransferase DUF685 PF05085.7 KII74049.1 - 5.9e-05 22.2 0.5 14 4.5 0.0 4.8 1 1 3 5 5 5 0 Protein of unknown function (DUF685) YfmQ PF10787.4 KII74049.1 - 0.00016 21.0 1.8 45 3.3 0.0 5.0 5 0 0 5 5 5 0 Uncharacterised protein from bacillus cereus group CTDII PF01556.13 KII74049.1 - 0.0002 21.1 21.8 6 6.8 0.2 6.1 2 1 4 6 6 6 4 DnaJ C terminal domain Lipase_GDSL_3 PF14606.1 KII74049.1 - 0.00049 19.8 0.0 88 2.7 0.0 5.3 6 0 0 6 6 6 0 GDSL-like Lipase/Acylhydrolase family YajC PF02699.10 KII74049.1 - 0.0019 17.8 12.5 20 4.9 0.0 5.8 6 0 0 6 6 6 0 Preprotein translocase subunit FlgD_ig PF13860.1 KII74049.1 - 0.0031 17.2 7.6 39 4.0 0.0 5.2 5 0 0 5 5 5 0 FlgD Ig-like domain Myosin_N PF02736.14 KII74049.1 - 0.028 14.1 11.3 99 2.7 0.0 6.8 6 0 0 6 6 6 0 Myosin N-terminal SH3-like domain GABP-alpha PF11620.3 KII74049.1 - 0.046 13.6 9.9 53 3.9 0.1 4.9 5 0 0 5 5 5 0 GA-binding protein alpha chain DUF3781 PF12636.2 KII74049.1 - 0.096 12.6 6.5 1.6e+02 2.3 0.0 5.0 5 0 0 5 5 5 0 Protein of unknown function (DUF3781) Mt_ATP-synt_D PF05873.7 KII74050.1 - 0.00027 20.5 1.4 0.00073 19.2 0.1 1.8 1 1 1 2 2 2 1 ATP synthase D chain, mitochondrial (ATP5H) HTH_29 PF13551.1 KII74051.1 - 2.6e-05 24.3 0.0 3.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII74051.1 - 3e-05 23.9 0.1 6.7e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 KII74051.1 - 5.9e-05 22.5 0.0 0.00012 21.6 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.13 KII74051.1 - 0.00062 19.4 0.1 0.0008 19.1 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_38 PF13936.1 KII74051.1 - 0.0026 17.2 0.0 0.051 13.1 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Crp_2 PF13545.1 KII74051.1 - 0.019 14.7 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII74051.1 - 0.023 14.3 0.1 0.033 13.8 0.1 1.2 1 0 0 1 1 1 0 Transposase HTH_11 PF08279.7 KII74051.1 - 0.041 13.5 0.3 0.074 12.7 0.2 1.5 1 0 0 1 1 1 0 HTH domain TK PF00265.13 KII74052.1 - 2e-30 105.6 0.1 2.2e-30 105.4 0.1 1.0 1 0 0 1 1 1 1 Thymidine kinase Mito_carr PF00153.22 KII74057.1 - 1.1e-21 76.2 0.0 1.2e-21 76.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein CTD_bind PF04818.8 KII74059.1 - 5.9e-07 29.6 0.2 2.8e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase II-binding domain. DUF4250 PF14056.1 KII74059.1 - 1.8 8.3 4.8 0.63 9.8 0.6 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4250) WD40 PF00400.27 KII74060.1 - 2e-13 49.6 10.3 2.4e-06 27.1 0.9 4.2 5 0 0 5 5 5 3 WD domain, G-beta repeat CPSF_A PF03178.10 KII74060.1 - 0.0038 16.3 0.0 0.0052 15.9 0.0 1.3 1 1 0 1 1 1 1 CPSF A subunit region Fer4_9 PF13187.1 KII74060.1 - 0.22 11.7 3.4 0.44 10.8 2.4 1.6 1 1 0 1 1 1 0 4Fe-4S dicluster domain NLE PF08154.7 KII74061.1 - 2.7e-05 24.0 0.1 4.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.27 KII74061.1 - 0.0012 18.6 1.1 0.011 15.6 0.2 2.4 2 1 0 2 2 2 1 WD domain, G-beta repeat DUF4625 PF15418.1 KII74061.1 - 0.015 15.3 0.7 0.021 14.9 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) eIF-1a PF01176.14 KII74063.1 - 0.0095 15.3 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Ldl_recept_a PF00057.13 KII74064.1 - 1.3e-25 88.9 62.2 7.1e-10 38.6 10.3 4.7 4 1 0 4 4 4 4 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII74065.1 - 1e-08 34.9 22.0 5.4e-05 23.0 5.9 2.6 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Kinesin PF00225.18 KII74066.1 - 2.9e-21 75.5 0.0 3.4e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Rep_fac-A_3 PF08661.6 KII74066.1 - 0.011 15.6 0.2 0.016 15.1 0.1 1.2 1 0 0 1 1 1 0 Replication factor A protein 3 PIF1 PF05970.9 KII74066.1 - 0.025 13.5 0.1 0.036 13.0 0.1 1.1 1 0 0 1 1 1 0 PIF1-like helicase Kinesin PF00225.18 KII74067.1 - 5.9e-51 173.1 0.1 7e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain MAP65_ASE1 PF03999.7 KII74067.1 - 0.027 13.1 0.2 0.034 12.7 0.1 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Reo_sigmaC PF04582.7 KII74068.1 - 0.073 12.2 1.8 0.1 11.7 1.3 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein ADIP PF11559.3 KII74068.1 - 0.32 10.8 26.7 0.59 10.0 11.3 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Alg14 PF08660.6 KII74068.1 - 0.52 10.2 3.7 0.45 10.4 1.4 1.7 1 1 1 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like CENP-F_leu_zip PF10473.4 KII74068.1 - 0.9 9.3 19.9 0.58 10.0 11.0 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BPL_N PF09825.4 KII74068.1 - 5.8 5.5 8.2 9 4.9 5.6 1.4 1 1 0 1 1 1 0 Biotin-protein ligase, N terminal Pox_polyA_pol_C PF12629.2 KII74069.1 - 0.01 15.5 0.1 0.013 15.2 0.1 1.1 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain SARS_X4 PF08779.5 KII74069.1 - 0.075 13.2 0.1 4.4 7.5 0.0 2.1 1 1 1 2 2 2 0 SARS coronavirus X4 like LAG1-DNAbind PF09271.6 KII74073.1 - 1.3e-05 25.6 0.6 0.00082 19.8 0.1 2.9 2 1 1 3 3 3 1 LAG1, DNA binding ITAM_Cys-rich PF10538.4 KII74075.1 - 0.1 12.1 0.7 0.1 12.1 0.5 1.8 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif DNA_pol3_a_NII PF11490.3 KII74077.1 - 0.015 14.9 1.8 0.031 13.8 1.3 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Mad3_BUB1_I PF08311.7 KII74078.1 - 2.6e-19 69.2 1.9 4.3e-19 68.5 1.3 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 MMR_HSR1 PF01926.18 KII74079.1 - 7.5e-15 54.9 0.0 1.3e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KII74079.1 - 0.00022 20.5 0.3 0.00056 19.2 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 KII74079.1 - 0.0013 17.9 0.0 0.0028 16.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 KII74079.1 - 0.021 15.3 0.0 0.043 14.3 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein AAA_18 PF13238.1 KII74079.1 - 0.031 14.5 0.0 3.1 8.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 KII74079.1 - 0.044 13.6 0.3 0.044 13.6 0.2 2.6 2 1 1 3 3 3 0 Dynamin family 120_Rick_ant PF12574.3 KII74079.1 - 0.074 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 120 KDa Rickettsia surface antigen Thioredoxin_6 PF13848.1 KII74080.1 - 1.6e-12 47.5 11.7 1.8e-07 31.1 0.1 4.0 3 1 1 4 4 4 3 Thioredoxin-like domain Thioredoxin PF00085.15 KII74080.1 - 1.6e-08 34.1 0.0 0.0066 16.1 0.0 4.2 4 0 0 4 4 4 2 Thioredoxin PK PF00224.16 KII74081.1 - 6.4e-61 205.8 0.5 8e-61 205.5 0.3 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KII74081.1 - 1.2e-23 82.8 0.0 2.8e-23 81.6 0.0 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain RVT_1 PF00078.22 KII74083.1 - 1.4e-14 54.0 0.0 1.9e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.5 KII74084.1 - 0.0017 17.6 0.1 0.0037 16.6 0.1 1.6 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger rve PF00665.21 KII74084.1 - 0.068 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain zf-Sec23_Sec24 PF04810.10 KII74084.1 - 0.21 11.1 0.9 2.8 7.5 0.0 2.5 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger DDE_3 PF13358.1 KII74086.1 - 1.4e-14 54.0 0.0 1.6e-14 53.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease PK PF00224.16 KII74087.1 - 3.6e-126 420.4 9.4 4.4e-126 420.1 6.5 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KII74087.1 - 2.6e-24 85.0 0.0 1.9e-23 82.2 0.0 2.4 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 KII74087.1 - 8.5e-08 31.3 0.9 1.6e-07 30.4 0.5 1.5 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Nairo_nucleo PF02477.10 KII74087.1 - 0.021 13.5 0.1 0.034 12.8 0.0 1.3 1 0 0 1 1 1 0 Nucleocapsid N protein zf-C2H2_4 PF13894.1 KII74088.1 - 0.0001 22.3 16.4 0.074 13.4 0.6 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 KII74088.1 - 0.0023 18.1 18.3 0.36 11.2 0.0 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KII74088.1 - 4.7 7.6 28.1 0.24 11.7 2.5 3.7 3 1 1 4 4 4 0 Zinc-finger double domain Aldo_ket_red PF00248.16 KII74090.1 - 6.1e-09 35.1 0.0 7.4e-09 34.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 KII74091.1 - 5.3e-34 117.3 0.0 6e-34 117.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RVP PF00077.15 KII74092.1 - 0.0016 18.3 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF454 PF04304.8 KII74092.1 - 0.027 14.4 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF454) Peptidase_A2E PF12382.3 KII74092.1 - 0.05 13.4 0.0 0.1 12.3 0.0 1.6 1 1 0 1 1 1 0 Retrotransposon peptidase Mt_ATP-synt_B PF05405.9 KII74092.1 - 0.071 12.5 0.2 0.57 9.6 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF750 PF04721.12 KII74099.1 - 0.031 14.2 0.5 0.096 12.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF750) B12-binding PF02310.14 KII74100.1 - 1.2e-11 44.5 0.1 1.4e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 B12 binding domain MM_CoA_mutase PF01642.17 KII74101.1 - 9.1e-50 169.2 0.2 1e-49 169.0 0.1 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase DDE_3 PF13358.1 KII74102.1 - 0.0019 17.9 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2140 PF09911.4 KII74103.1 - 0.012 14.7 0.1 0.019 14.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) RVT_1 PF00078.22 KII74106.1 - 1.1e-09 37.9 0.1 4.1e-09 36.1 0.1 1.9 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) TolA PF06519.6 KII74106.1 - 0.053 13.5 0.0 6 6.9 0.0 2.8 2 0 0 2 2 2 0 TolA C-terminal DDE_3 PF13358.1 KII74107.1 - 1.6e-08 34.4 0.0 2.3e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.2 KII74108.1 - 0.00011 22.0 0.0 0.00015 21.6 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Borrelia_REV PF03978.8 KII74110.1 - 0.029 14.0 0.1 0.03 14.0 0.1 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein zf-C2H2 PF00096.21 KII74113.1 - 1.6 9.2 4.0 1 9.8 1.3 1.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF600 PF04634.7 KII74115.1 - 0.02 14.9 0.3 0.03 14.3 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF600 zf-CCHC PF00098.18 KII74116.1 - 0.00018 21.3 0.8 0.00018 21.3 0.6 2.7 3 0 0 3 3 3 1 Zinc knuckle RVT_1 PF00078.22 KII74117.1 - 2.5e-18 66.2 0.0 6.9e-18 64.7 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII74117.1 - 0.0035 17.2 0.0 0.011 15.6 0.0 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII74117.1 - 0.075 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Pox_F17 PF04767.7 KII74120.1 - 0.024 14.8 0.3 0.037 14.2 0.2 1.2 1 0 0 1 1 1 0 DNA-binding 11 kDa phosphoprotein AIG1 PF04548.11 KII74122.1 - 0.025 13.7 0.1 0.028 13.5 0.1 1.0 1 0 0 1 1 1 0 AIG1 family Fibrinogen_BP PF08017.6 KII74122.1 - 0.027 12.6 0.1 0.028 12.6 0.0 1.0 1 0 0 1 1 1 0 Fibrinogen binding protein DUF2945 PF11160.3 KII74125.1 - 0.04 13.7 0.1 0.092 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2945) zf-BED PF02892.10 KII74127.1 - 0.037 13.7 3.6 0.037 13.7 2.5 2.3 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_jaz PF12171.3 KII74127.1 - 0.048 13.8 0.9 8.9 6.6 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF4367 PF14285.1 KII74127.1 - 0.31 10.3 1.9 0.6 9.4 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) zf-C2H2 PF00096.21 KII74127.1 - 2 8.9 8.2 11 6.6 2.1 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2HC_2 PF13913.1 KII74127.1 - 3.5 7.4 6.3 0.75 9.5 1.1 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type HPIH PF13323.1 KII74129.1 - 0.096 12.3 0.1 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain with HPIH motif VCBS PF13517.1 KII74133.1 - 2.6e-07 30.9 0.7 5e-06 26.7 0.2 1.7 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KII74133.1 - 0.00079 19.0 1.0 1 9.1 0.8 2.5 2 0 0 2 2 2 2 FG-GAP repeat DUF4367 PF14285.1 KII74133.1 - 0.067 12.5 0.0 0.084 12.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) CENP-B_N PF04218.8 KII74134.1 - 1.6e-06 27.4 0.0 2.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Herpes_UL52 PF03121.10 KII74135.1 - 0.002 17.8 0.5 0.004 16.8 0.4 1.5 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase FLYWCH PF04500.11 KII74136.1 - 0.0015 18.3 4.5 0.0026 17.6 3.1 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain Intg_mem_TP0381 PF09529.5 KII74137.1 - 0.014 14.6 0.7 0.015 14.5 0.5 1.2 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) DUF2418 PF10332.4 KII74137.1 - 0.31 11.3 2.0 0.49 10.7 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) DUF3196 PF11428.3 KII74138.1 - 0.00064 19.1 3.8 0.00077 18.8 2.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3196) IncA PF04156.9 KII74138.1 - 0.25 10.9 2.6 0.36 10.4 1.8 1.2 1 0 0 1 1 1 0 IncA protein Laminin_II PF06009.7 KII74138.1 - 0.3 10.8 2.3 3.3 7.4 0.4 2.1 1 1 1 2 2 2 0 Laminin Domain II DDE_3 PF13358.1 KII74140.1 - 8.5e-15 54.7 0.0 1.2e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII74140.1 - 0.047 13.7 0.0 0.068 13.2 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Ldl_recept_a PF00057.13 KII74142.1 - 3.5e-18 65.2 36.6 3.4e-12 46.0 7.0 3.1 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A A_thal_3526 PF09713.5 KII74147.1 - 0.026 14.6 0.2 0.053 13.6 0.1 1.5 1 0 0 1 1 1 0 Plant protein 1589 of unknown function (A_thal_3526) CC PF04942.9 KII74148.1 - 2.8 7.9 6.7 0.89 9.4 0.6 2.6 2 1 0 2 2 2 0 CC domain TUDOR PF00567.19 KII74149.1 - 5.6e-17 61.7 0.0 1e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.7 KII74149.1 - 2e-05 23.8 0.0 2.9e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) DUF4537 PF15057.1 KII74149.1 - 0.0046 16.7 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) LRR_6 PF13516.1 KII74151.1 - 2.7e-16 57.7 9.7 0.13 12.3 0.1 5.7 4 1 1 5 5 5 5 Leucine Rich repeat LRR_4 PF12799.2 KII74151.1 - 3.2e-06 26.6 15.3 0.0089 15.6 0.0 4.0 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KII74151.1 - 8.1e-06 25.5 10.5 0.017 14.8 0.2 3.5 1 1 3 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 KII74151.1 - 0.0002 20.9 8.5 8.9 6.7 0.1 4.8 4 1 0 4 4 4 3 Leucine Rich Repeat LRR_7 PF13504.1 KII74151.1 - 0.00054 19.7 8.3 16 6.2 0.2 5.3 5 0 0 5 5 5 2 Leucine rich repeat LRR_4 PF12799.2 KII74152.1 - 2.4e-07 30.2 0.1 0.0015 18.0 0.0 3.0 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KII74152.1 - 2e-06 27.2 0.6 0.95 9.7 0.0 3.6 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.28 KII74152.1 - 0.00013 21.4 0.1 1.8 8.8 0.0 3.3 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_8 PF13855.1 KII74152.1 - 0.012 15.3 0.3 0.11 12.2 0.2 2.3 1 1 0 1 1 1 0 Leucine rich repeat LRR_7 PF13504.1 KII74152.1 - 0.027 14.5 0.1 20 5.9 0.0 3.2 3 0 0 3 3 3 0 Leucine rich repeat PSII_BNR PF14870.1 KII74152.1 - 0.029 13.3 0.2 0.04 12.9 0.1 1.1 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 Neurochondrin PF05536.6 KII74153.1 - 1.8e-09 36.4 0.8 3.6e-09 35.4 0.6 1.5 1 1 0 1 1 1 1 Neurochondrin GTP_EFTU PF00009.22 KII74154.1 - 1.1e-05 24.9 0.6 6.4e-05 22.4 0.5 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 KII74154.1 - 0.0008 19.4 0.3 0.0058 16.7 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Miro PF08477.8 KII74154.1 - 0.047 14.1 0.5 0.16 12.4 0.1 2.1 2 1 0 2 2 2 0 Miro-like protein AAA_28 PF13521.1 KII74154.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain rve PF00665.21 KII74158.1 - 3.5e-26 91.6 0.0 5.9e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74158.1 - 7.5e-06 25.3 0.0 1.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII74158.1 - 0.016 14.9 0.0 0.032 13.9 0.0 1.6 1 1 0 1 1 1 0 DDE superfamily endonuclease rve PF00665.21 KII74159.1 - 6.9e-22 77.7 0.0 2.1e-21 76.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII74159.1 - 4.5e-19 68.6 0.0 1.3e-18 67.2 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII74159.1 - 2.8e-06 27.1 0.1 9.8e-06 25.4 0.1 2.0 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII74159.1 - 0.0022 17.4 0.4 0.0087 15.5 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Asp_protease PF09668.5 KII74159.1 - 0.0041 16.6 1.0 0.0094 15.5 0.7 1.6 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 KII74159.1 - 0.0071 16.8 0.0 0.016 15.6 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease HNH_4 PF13395.1 KII74160.1 - 0.0057 16.2 0.0 0.013 15.0 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease DDE_Tnp_IS1595 PF12762.2 KII74161.1 - 4.7e-13 49.2 0.0 6e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain CLU_N PF15044.1 KII74166.1 - 0.02 15.0 0.1 1.2 9.3 0.0 2.5 1 1 1 2 2 2 0 Mitochondrial function, CLU-N-term RhoGAP PF00620.22 KII74168.1 - 9.7e-35 119.4 0.2 1.9e-34 118.4 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain DUF3426 PF11906.3 KII74169.1 - 0.0015 18.2 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3426) Guanylate_cyc PF00211.15 KII74170.1 - 4.9e-47 159.6 0.2 7.8e-47 159.0 0.1 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3853 PF12964.2 KII74170.1 - 0.01 15.6 0.0 4.3 7.2 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3853) Pkinase_Tyr PF07714.12 KII74170.1 - 0.011 14.8 0.1 0.021 13.8 0.1 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase HNOBA PF07701.9 KII74170.1 - 0.016 14.4 0.7 0.062 12.4 0.3 1.9 2 0 0 2 2 2 0 Heme NO binding associated Archease PF01951.11 KII74170.1 - 0.027 14.4 0.7 0.1 12.5 0.1 2.1 2 0 0 2 2 2 0 Archease protein family (MTH1598/TM1083) DUF3452 PF11934.3 KII74170.1 - 0.089 12.1 1.5 0.99 8.7 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) Gelsolin PF00626.17 KII74171.1 - 4.5e-25 87.1 1.5 1.3e-06 27.9 0.0 4.5 4 0 0 4 4 4 4 Gelsolin repeat LRR_8 PF13855.1 KII74172.1 - 2.5e-39 132.8 40.0 1.2e-11 44.2 1.5 7.4 5 3 4 9 9 9 8 Leucine rich repeat LRR_4 PF12799.2 KII74172.1 - 4e-31 106.1 44.7 5.1e-09 35.5 2.0 9.5 6 2 5 12 12 12 9 Leucine Rich repeats (2 copies) Gelsolin PF00626.17 KII74172.1 - 2.6e-18 65.4 0.0 2.8e-12 46.1 0.0 2.6 2 0 0 2 2 2 2 Gelsolin repeat LRR_1 PF00560.28 KII74172.1 - 1.7e-15 54.6 38.7 0.077 13.0 0.3 13.8 14 1 1 15 15 15 7 Leucine Rich Repeat LRR_7 PF13504.1 KII74172.1 - 9.9e-09 34.0 23.5 5.6 7.6 0.0 11.1 12 1 0 12 12 12 2 Leucine rich repeat LRR_6 PF13516.1 KII74172.1 - 0.0034 17.2 39.4 0.82 9.9 0.1 12.3 12 2 2 14 14 14 2 Leucine Rich repeat KRTDAP PF15200.1 KII74172.1 - 0.027 14.2 0.6 0.77 9.5 0.0 3.1 3 0 0 3 3 3 0 Keratinocyte differentiation-associated DUF4098 PF13345.1 KII74172.1 - 0.35 10.8 7.0 2.8 7.9 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4098) SNF2_N PF00176.18 KII74173.1 - 6.8e-77 258.1 1.0 1.5e-76 257.0 0.7 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Bromodomain PF00439.20 KII74173.1 - 8.3e-20 70.5 0.5 1e-18 67.0 0.1 2.7 2 0 0 2 2 2 1 Bromodomain Helicase_C PF00271.26 KII74173.1 - 2.6e-16 59.2 0.0 2.7e-15 56.0 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.24 KII74173.1 - 0.00038 19.9 0.1 0.002 17.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase SnAC PF14619.1 KII74173.1 - 0.001 19.1 1.0 0.001 19.1 0.7 3.3 2 1 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.8 KII74173.1 - 0.0035 17.1 11.1 0.0099 15.6 7.7 1.9 1 0 0 1 1 1 1 HSA Apc4_WD40 PF12894.2 KII74173.1 - 0.049 13.1 0.6 2 7.9 0.1 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain ROS_MUCR PF05443.6 KII74175.1 - 0.0075 16.0 0.8 0.02 14.6 0.1 2.1 2 0 0 2 2 2 1 ROS/MUCR transcriptional regulator protein EST1 PF10374.4 KII74175.1 - 0.022 14.7 1.8 0.022 14.7 1.2 2.8 2 1 0 2 2 2 0 Telomerase activating protein Est1 SH3BGR PF04908.10 KII74175.1 - 0.05 13.5 0.1 0.22 11.5 0.1 2.1 1 1 0 1 1 1 0 SH3-binding, glutamic acid-rich protein RUN PF02759.14 KII74175.1 - 1.7 8.3 6.8 2.2 8.0 0.4 3.1 4 0 0 4 4 4 0 RUN domain DUF4422 PF14393.1 KII74175.1 - 9.2 5.7 15.9 2.9 7.4 0.6 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4422) bZIP_2 PF07716.10 KII74177.1 - 0.00011 21.8 1.7 0.00011 21.8 1.2 2.0 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.16 KII74177.1 - 0.0011 18.8 5.4 0.0011 18.8 3.7 2.3 1 1 1 2 2 2 1 bZIP transcription factor Chisel PF15355.1 KII74177.1 - 0.027 14.4 0.0 0.058 13.4 0.0 1.6 1 0 0 1 1 1 0 Stretch-responsive small skeletal muscle X protein, Chisel Ead_Ea22 PF13935.1 KII74177.1 - 0.11 12.8 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Ead/Ea22-like protein RICH PF05062.7 KII74177.1 - 0.12 12.4 1.4 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 RICH domain GBP PF02263.14 KII74178.1 - 4.5e-45 153.7 0.0 5.4e-45 153.4 0.0 1.0 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.9 KII74179.1 - 0.0014 17.9 0.3 0.0017 17.5 0.2 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain DUF2207 PF09972.4 KII74179.1 - 0.04 12.5 0.9 0.04 12.5 0.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SUR7 PF06687.7 KII74179.1 - 0.043 13.3 0.3 0.045 13.3 0.2 1.1 1 0 0 1 1 1 0 SUR7/PalI family DUF3007 PF11460.3 KII74179.1 - 2.2 8.4 4.1 1.4 9.0 1.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) eIF-6 PF01912.13 KII74181.1 - 1.7e-76 255.7 0.1 2e-76 255.5 0.1 1.0 1 0 0 1 1 1 1 eIF-6 family DUF2344 PF10105.4 KII74181.1 - 0.024 14.1 0.0 0.032 13.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) PHF5 PF03660.9 KII74182.1 - 1.1e-46 157.2 13.5 1.5e-46 156.8 9.3 1.2 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.8 KII74182.1 - 0.67 7.5 6.9 0.75 7.3 4.8 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DEDD_Tnp_IS110 PF01548.12 KII74183.1 - 0.015 14.9 0.0 0.035 13.7 0.0 1.6 1 1 1 2 2 2 0 Transposase KH_1 PF00013.24 KII74185.1 - 2.9e-05 23.6 0.3 5.6e-05 22.6 0.2 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.18 KII74190.1 - 0.02 14.7 0.6 0.052 13.4 0.4 1.8 1 0 0 1 1 1 0 Zinc knuckle P_proprotein PF01483.15 KII74190.1 - 0.12 12.2 0.1 3.1 7.6 0.0 2.4 2 0 0 2 2 2 0 Proprotein convertase P-domain RVP_2 PF08284.6 KII74190.1 - 0.44 10.4 2.8 0.21 11.5 0.2 1.7 2 0 0 2 2 2 0 Retroviral aspartyl protease RVT_1 PF00078.22 KII74191.1 - 1.3e-07 31.1 0.0 3.9e-07 29.6 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A17 PF05380.8 KII74192.1 - 0.095 12.5 0.0 0.14 11.9 0.0 1.3 1 1 0 1 1 1 0 Pao retrotransposon peptidase ThaI PF15514.1 KII74195.1 - 0.021 14.1 0.2 0.026 13.8 0.2 1.1 1 0 0 1 1 1 0 Restriction endonuclease ThaI RVT_1 PF00078.22 KII74196.1 - 1e-06 28.2 0.3 6e-06 25.7 0.2 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.9 KII74196.1 - 0.044 13.6 0.2 0.083 12.8 0.1 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-DHHC PF01529.15 KII74198.1 - 1.4 8.2 3.9 1.7 7.9 2.7 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase MULE PF10551.4 KII74199.1 - 6.3e-10 39.0 0.0 1.4e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.11 KII74199.1 - 9.8e-09 34.9 0.2 1.9e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain DDE_1 PF03184.14 KII74202.1 - 0.005 16.0 0.0 0.0057 15.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease GPW_gp25 PF04965.9 KII74203.1 - 0.022 14.2 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 Gene 25-like lysozyme DUF4250 PF14056.1 KII74205.1 - 0.029 14.0 0.1 1.3 8.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) HMA PF00403.21 KII74205.1 - 0.029 14.5 0.1 0.12 12.4 0.0 2.1 3 0 0 3 3 3 0 Heavy-metal-associated domain HemeBinding_Shp PF11545.3 KII74205.1 - 0.052 13.3 0.0 0.059 13.1 0.0 1.1 1 0 0 1 1 1 0 Cell surface heme-binding protein Shp DUF1664 PF07889.7 KII74205.1 - 0.12 12.1 0.9 0.2 11.4 0.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PGM_PMM_I PF02878.11 KII74207.1 - 9.4e-27 93.1 0.0 1.5e-26 92.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 KII74207.1 - 4.6e-20 71.7 0.0 1.1e-19 70.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 KII74207.1 - 1.7e-12 47.5 0.0 4.9e-12 46.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 KII74207.1 - 1e-07 31.8 0.0 2.2e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DBR1 PF05011.8 KII74208.1 - 5.2e-14 52.3 0.5 1.7e-11 44.2 0.0 2.3 1 1 1 2 2 2 2 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 KII74208.1 - 2.5e-08 33.5 2.8 5.5e-08 32.4 2.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KII74208.1 - 0.0018 18.1 0.1 0.0029 17.4 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DMAP1 PF05499.7 KII74209.1 - 2.4e-21 76.0 0.2 9.5e-21 74.1 0.0 1.9 2 0 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) DUF3527 PF12043.3 KII74209.1 - 0.045 13.2 0.1 0.07 12.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) DDRGK PF09756.4 KII74210.1 - 8.3e-44 149.2 24.1 1e-43 148.9 16.7 1.1 1 0 0 1 1 1 1 DDRGK domain IncA PF04156.9 KII74210.1 - 0.0022 17.6 8.4 0.0034 17.0 5.8 1.3 1 0 0 1 1 1 1 IncA protein FeoC PF09012.5 KII74210.1 - 0.033 13.8 0.0 2.5 7.8 0.0 2.5 2 0 0 2 2 2 0 FeoC like transcriptional regulator Peptidase_S49_N PF08496.5 KII74210.1 - 0.047 13.4 0.2 0.047 13.4 0.1 2.2 1 1 1 2 2 2 0 Peptidase family S49 N-terminal Asp-B-Hydro_N PF05279.6 KII74210.1 - 1.4 8.7 21.3 1.7 8.4 14.8 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CAF-1_p150 PF11600.3 KII74210.1 - 1.9 7.8 34.0 2.6 7.3 23.6 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Med19 PF10278.4 KII74210.1 - 3.1 7.4 12.9 4.6 6.8 8.9 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 V_ATPase_I PF01496.14 KII74210.1 - 4.2 5.1 15.1 5.7 4.6 10.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BTV_NS2 PF04514.7 KII74210.1 - 5.3 5.8 16.9 6.7 5.4 11.7 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 PDZ PF00595.19 KII74211.1 - 9.5e-10 38.5 0.0 1.9e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII74211.1 - 1e-05 25.3 0.0 2.4e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF4299 PF14132.1 KII74211.1 - 0.019 14.1 0.3 0.042 12.9 0.0 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4299) FlpD PF02662.11 KII74211.1 - 0.051 13.2 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit Leo1 PF04004.8 KII74212.1 - 6e-48 162.7 0.1 1.3e-47 161.6 0.0 1.6 2 0 0 2 2 2 1 Leo1-like protein RRP14 PF15459.1 KII74212.1 - 0.039 14.0 1.2 0.084 12.9 0.9 1.5 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 RRM_1 PF00076.17 KII74213.1 - 3.4e-14 52.2 0.0 5e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII74213.1 - 1.1e-10 41.2 0.0 1.8e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII74213.1 - 0.00015 21.5 0.0 0.00021 21.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldedh PF00171.17 KII74215.1 - 9.9e-06 24.1 0.1 1.2e-05 23.9 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family BRCT PF00533.21 KII74216.1 - 0.028 14.5 0.0 0.052 13.6 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain SWIRM PF04433.12 KII74217.1 - 2.8e-17 62.6 1.1 6.6e-17 61.4 0.0 2.2 3 0 0 3 3 3 1 SWIRM domain Myb_DNA-binding PF00249.26 KII74217.1 - 0.0018 18.3 0.0 0.0048 16.9 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KII74217.1 - 0.0026 17.8 0.0 0.0066 16.5 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain EFG_IV PF03764.13 KII74218.1 - 1.8e-24 85.5 0.0 3.5e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 KII74218.1 - 8.2e-24 83.3 0.0 2.6e-23 81.7 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KII74218.1 - 6.1e-11 42.2 0.0 1.3e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 KII74218.1 - 1.2e-07 31.4 0.0 2.7e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II Proteasome PF00227.21 KII74221.1 - 4.3e-27 94.6 0.0 5.8e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DDE_Tnp_IS1595 PF12762.2 KII74222.1 - 0.055 13.3 0.0 0.18 11.6 0.0 1.8 1 1 0 1 1 1 0 ISXO2-like transposase domain PsaM PF07465.8 KII74222.1 - 0.055 13.0 0.3 1.7 8.2 0.2 2.2 2 0 0 2 2 2 0 Photosystem I protein M (PsaM) zf-CCHC PF00098.18 KII74223.1 - 0.00082 19.1 1.7 0.0012 18.7 1.2 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 KII74223.1 - 0.017 14.7 0.4 0.029 14.0 0.3 1.4 1 0 0 1 1 1 0 Zinc knuckle DUF4632 PF15451.1 KII74223.1 - 0.074 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) YvrJ PF12841.2 KII74226.1 - 0.2 10.9 0.6 0.46 9.8 0.4 1.6 1 0 0 1 1 1 0 YvrJ protein family rve PF00665.21 KII74227.1 - 2.7e-25 88.7 0.0 4.4e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74227.1 - 0.0022 17.5 0.0 0.0097 15.4 0.0 2.2 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII74227.1 - 0.0035 17.3 0.2 0.019 14.9 0.0 2.1 2 0 0 2 2 2 1 DDE domain Transcript_VP30 PF11507.3 KII74227.1 - 0.063 13.1 0.0 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 Ebola virus-specific transcription factor VP30 Acetyltransf_4 PF13420.1 KII74229.1 - 0.023 14.6 0.2 0.03 14.2 0.1 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DNAJ_related PF12339.3 KII74229.1 - 0.089 12.6 0.3 0.11 12.3 0.2 1.1 1 0 0 1 1 1 0 DNA-J related protein FLYWCH PF04500.11 KII74230.1 - 5.8e-11 42.1 0.2 1.3e-10 40.9 0.1 1.7 1 0 0 1 1 1 1 FLYWCH zinc finger domain 2-Hacid_dh_C PF02826.14 KII74231.1 - 1e-56 190.9 0.0 1.5e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KII74231.1 - 6.4e-25 87.1 0.0 7.3e-25 86.9 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KII74231.1 - 2e-06 27.7 0.0 4.6e-06 26.5 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 KII74231.1 - 0.0089 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain GP4 PF03010.9 KII74231.1 - 0.057 13.0 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 GP4 UDPG_MGDP_dh_C PF03720.10 KII74231.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Na_sulph_symp PF00939.14 KII74232.1 - 1.5e-108 363.7 30.7 1.9e-108 363.3 21.3 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region Amidohydro_4 PF13147.1 KII74232.1 - 1.9e-19 70.7 0.7 3.6e-12 46.9 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_5 PF13594.1 KII74232.1 - 2.8e-10 39.8 1.7 2.8e-10 39.8 1.2 1.9 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_1 PF01979.15 KII74232.1 - 1e-07 31.9 3.9 1.3e-06 28.3 2.7 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 KII74232.1 - 4.2e-06 26.2 0.3 0.012 14.8 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Orthopox_A36R PF05950.6 KII74234.1 - 0.0094 15.8 2.3 0.017 15.0 1.6 1.3 1 0 0 1 1 1 1 Orthopoxvirus A36R protein DUF4551 PF15087.1 KII74234.1 - 0.25 9.6 8.7 0.36 9.1 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF2963 PF11178.3 KII74234.1 - 1.1 8.7 3.9 8.6 5.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) SR-25 PF10500.4 KII74235.1 - 0.0055 16.1 8.1 0.0055 16.1 5.6 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PIP49_N PF14875.1 KII74235.1 - 0.037 13.6 0.1 0.043 13.4 0.1 1.1 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 RNase_H2-Ydr279 PF09468.5 KII74235.1 - 0.11 11.6 5.5 0.12 11.5 3.8 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Tfb2 PF03849.9 KII74239.1 - 0.033 12.8 0.0 0.037 12.6 0.0 1.0 1 0 0 1 1 1 0 Transcription factor Tfb2 RPA_interact_C PF14768.1 KII74242.1 - 0.075 13.4 0.6 0.2 12.0 0.4 1.7 1 1 0 1 1 1 0 Replication protein A interacting C-terminal Nucleos_tra2_N PF01773.15 KII74244.1 - 0.066 13.5 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Na+ dependent nucleoside transporter N-terminus UPF0175 PF03683.8 KII74250.1 - 0.008 15.6 0.0 0.55 9.7 0.0 2.3 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0175) ocr PF08684.5 KII74252.1 - 0.016 15.2 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 DNA mimic ocr Kunitz_BPTI PF00014.18 KII74253.1 - 0.0049 17.0 15.1 0.026 14.7 3.5 2.8 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain PSI PF01437.20 KII74253.1 - 1.5 9.0 6.0 0.59 10.3 1.6 2.3 2 0 0 2 2 2 0 Plexin repeat CCDC155 PF14662.1 KII74255.1 - 0.01 15.4 1.3 0.01 15.4 0.9 1.8 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Atg14 PF10186.4 KII74255.1 - 0.079 11.8 2.0 0.077 11.9 0.5 1.6 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DivIC PF04977.10 KII74255.1 - 0.23 10.9 6.3 4.7 6.7 0.4 2.7 2 1 1 3 3 3 0 Septum formation initiator DUF1882 PF08966.6 KII74258.1 - 0.015 15.2 0.0 0.027 14.4 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1882) DDE_3 PF13358.1 KII74259.1 - 0.016 14.9 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease RVT_1 PF00078.22 KII74264.1 - 2.8e-12 46.4 0.1 5.6e-12 45.4 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Thg1 PF04446.7 KII74264.1 - 0.04 13.5 0.0 0.065 12.8 0.0 1.3 1 0 0 1 1 1 0 tRNAHis guanylyltransferase VirC1 PF07015.6 KII74265.1 - 0.11 11.5 0.0 0.12 11.4 0.0 1.0 1 0 0 1 1 1 0 VirC1 protein Z1 PF10593.4 KII74267.1 - 0.19 10.9 1.0 0.37 9.9 0.4 1.6 1 1 1 2 2 2 0 Z1 domain DUF4411 PF14367.1 KII74267.1 - 0.2 11.3 1.5 0.27 10.9 0.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4411) Herpes_PAP PF03325.8 KII74268.1 - 0.066 12.7 0.6 0.083 12.4 0.4 1.1 1 0 0 1 1 1 0 Herpesvirus polymerase accessory protein Phage_gp53 PF11246.3 KII74268.1 - 0.1 12.0 0.5 0.12 11.8 0.3 1.1 1 0 0 1 1 1 0 Base plate wedge protein 53 DDE_1 PF03184.14 KII74269.1 - 1.3e-29 102.8 1.9 2.2e-29 102.1 1.3 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII74269.1 - 8.2e-07 28.7 0.2 4.4e-06 26.4 0.0 2.3 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 KII74269.1 - 0.025 14.3 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease zf-CCCH PF00642.19 KII74276.1 - 2.8e-06 26.8 0.6 2.8e-06 26.8 0.4 2.8 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KII74276.1 - 0.0025 17.7 9.6 0.47 10.5 2.2 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type DUF629 PF04780.7 KII74276.1 - 0.0096 14.4 4.0 0.32 9.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF629) Asp_protease_2 PF13650.1 KII74278.1 - 7.5e-07 29.5 0.0 1.8e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII74278.1 - 1.9e-05 24.5 0.0 5.8e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII74278.1 - 0.00075 19.2 0.0 0.003 17.3 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII74278.1 - 0.012 15.1 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.18 KII74278.1 - 0.074 13.0 10.5 0.055 13.4 2.8 2.5 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.22 KII74279.1 - 1.2e-20 73.7 0.2 2.4e-20 72.8 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.9 KII74279.1 - 0.022 13.7 0.3 0.077 11.9 0.1 1.8 1 1 1 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Lipin_N PF04571.9 KII74279.1 - 0.089 12.4 0.1 1.6 8.4 0.0 2.6 3 0 0 3 3 3 0 lipin, N-terminal conserved region DUF4100 PF13352.1 KII74281.1 - 0.0037 16.7 2.9 0.0042 16.5 2.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4100) Rho_N PF07498.7 KII74281.1 - 0.004 16.8 0.1 0.01 15.6 0.1 1.7 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain FrhB_FdhB_N PF04422.8 KII74282.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term DcpS_C PF11969.3 KII74286.1 - 9.6e-30 103.1 0.2 1.1e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 KII74286.1 - 2.3e-26 92.1 0.3 2.9e-26 91.8 0.2 1.1 1 0 0 1 1 1 1 HIT domain DUF424 PF04242.8 KII74287.1 - 0.016 15.2 0.2 0.043 13.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF424) ecTbetaR2 PF08917.5 KII74288.1 - 0.083 12.6 0.2 0.32 10.7 0.1 2.0 2 1 1 3 3 3 0 Transforming growth factor beta receptor 2 ectodomain Pkinase PF00069.20 KII74289.1 - 8.2e-59 198.8 4.3 8.3e-59 198.8 0.0 2.7 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII74289.1 - 2.1e-34 118.7 1.9 3e-34 118.2 0.0 2.1 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.1 KII74289.1 - 2.3e-06 26.7 0.5 1.6e-05 23.9 0.0 2.5 3 0 0 3 3 3 1 Kinase-like APH PF01636.18 KII74289.1 - 0.0084 15.8 1.2 0.052 13.2 0.0 2.6 3 0 0 3 3 3 1 Phosphotransferase enzyme family FlgN PF05130.7 KII74289.1 - 0.017 15.3 0.4 0.017 15.3 0.3 3.4 3 0 0 3 3 3 0 FlgN protein Phospholip_A2_3 PF09056.6 KII74289.1 - 0.018 15.2 3.4 0.026 14.7 0.3 2.8 2 0 0 2 2 2 0 Prokaryotic phospholipase A2 dNK PF01712.14 KII74290.1 - 7e-17 61.7 0.7 9.2e-17 61.3 0.5 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.1 KII74290.1 - 0.00059 20.1 0.0 0.0016 18.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KII74290.1 - 0.01 16.6 0.0 0.028 15.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 KII74290.1 - 0.074 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Dynamin family Pkinase PF00069.20 KII74291.1 - 4.2e-30 104.7 7.1 5.5e-30 104.3 4.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII74291.1 - 3.7e-22 78.6 1.8 5.1e-22 78.1 1.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KII74291.1 - 1.2e-05 25.2 0.0 0.025 14.3 0.0 2.1 2 0 0 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 KII74291.1 - 0.0002 20.9 6.8 0.068 12.7 0.4 2.2 1 1 1 2 2 2 2 Choline/ethanolamine kinase Kdo PF06293.9 KII74291.1 - 0.00031 19.8 0.2 0.00048 19.2 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 KII74291.1 - 0.00062 19.1 1.2 0.23 10.7 0.1 2.4 1 1 1 2 2 2 2 PhoP regulatory network protein YrbL RIO1 PF01163.17 KII74291.1 - 0.0035 16.7 5.3 0.028 13.7 1.3 2.2 1 1 1 2 2 2 1 RIO1 family MRP-S35 PF10246.4 KII74291.1 - 0.073 13.0 0.0 0.22 11.5 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal protein MRP-S35 Kazal_2 PF07648.10 KII74291.1 - 0.089 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain HTH_33 PF13592.1 KII74292.1 - 0.0054 16.2 0.0 0.0093 15.4 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_29 PF13551.1 KII74292.1 - 0.0074 16.4 0.1 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII74292.1 - 0.013 15.5 1.7 0.11 12.5 0.1 2.2 2 0 0 2 2 2 0 Transposase HTH_32 PF13565.1 KII74292.1 - 0.059 14.1 0.1 0.2 12.5 0.0 1.9 2 1 0 2 2 2 0 Homeodomain-like domain IF3_N PF05198.11 KII74292.1 - 0.13 12.1 0.1 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain Helicase_C_2 PF13307.1 KII74293.1 - 1.1e-50 171.8 5.4 3.9e-50 170.0 0.1 3.0 3 0 0 3 3 3 1 Helicase C-terminal domain DEAD_2 PF06733.10 KII74293.1 - 2.8e-42 144.0 9.1 5.3e-42 143.1 6.3 1.5 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.24 KII74293.1 - 6.6e-07 28.9 0.0 0.0013 18.2 0.0 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.10 KII74293.1 - 1.1e-05 25.3 0.3 0.00056 19.7 0.2 2.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_11 PF13086.1 KII74293.1 - 0.00031 20.3 1.2 0.0009 18.8 0.8 1.7 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 KII74293.1 - 0.0052 16.0 0.0 1.6 7.9 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_19 PF13245.1 KII74293.1 - 0.048 13.4 0.0 0.18 11.5 0.0 1.9 1 1 0 1 1 1 0 Part of AAA domain zf-Nse PF11789.3 KII74294.1 - 4.1e-18 64.6 0.2 7.2e-18 63.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KII74294.1 - 2e-08 33.8 0.1 3.9e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-MIZ PF02891.15 KII74294.1 - 0.00018 20.9 0.1 0.00036 19.9 0.1 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger Rtf2 PF04641.7 KII74294.1 - 0.0019 17.4 0.3 0.0035 16.5 0.1 1.5 1 1 0 1 1 1 1 Rtf2 RING-finger zf-RING_2 PF13639.1 KII74294.1 - 0.0023 17.7 0.1 0.0043 16.8 0.0 1.4 1 0 0 1 1 1 1 Ring finger domain DnaB_2 PF07261.6 KII74294.1 - 0.0063 16.0 0.7 0.016 14.7 0.5 1.8 1 1 0 1 1 1 1 Replication initiation and membrane attachment Stomoxyn PF11585.3 KII74294.1 - 0.0063 16.2 0.3 0.24 11.2 0.2 2.8 2 0 0 2 2 2 1 Insect antimicrobial peptide, stomoxyn Vma12 PF11712.3 KII74294.1 - 0.02 14.5 0.6 0.028 14.1 0.4 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Vip3A_N PF12495.3 KII74294.1 - 0.022 14.4 1.5 0.033 13.8 1.0 1.4 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal DUF1664 PF07889.7 KII74294.1 - 0.031 14.0 3.7 0.13 12.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Arteri_GP4 PF02497.10 KII74294.1 - 0.036 13.9 0.3 0.12 12.3 0.1 1.8 1 1 1 2 2 2 0 Arterivirus glycoprotein L31 PF09784.4 KII74294.1 - 0.066 13.2 3.3 5.4 7.1 0.4 2.2 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 zf-C3HC4_4 PF15227.1 KII74294.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING KAR PF15222.1 KII74294.1 - 0.14 12.2 3.9 2.3 8.3 0.2 2.2 1 1 1 2 2 2 0 Kidney androgen-regulated Collagen_bind PF05737.7 KII74294.1 - 0.18 11.9 4.6 0.26 11.4 3.2 1.2 1 0 0 1 1 1 0 Collagen binding domain Syntaxin_2 PF14523.1 KII74294.1 - 0.38 10.7 5.3 2.8 8.0 0.7 2.3 1 1 1 2 2 2 0 Syntaxin-like protein Fib_alpha PF08702.5 KII74294.1 - 1.7 8.7 6.8 3.3 7.8 4.4 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family COG6 PF06419.6 KII74296.1 - 0.006 14.7 0.2 0.0084 14.3 0.2 1.2 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 AAA_32 PF13654.1 KII74296.1 - 0.025 13.2 0.0 0.032 12.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain KxDL PF10241.4 KII74296.1 - 0.052 13.4 0.2 0.11 12.4 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein LRR_4 PF12799.2 KII74297.1 - 9.7e-17 60.1 2.7 5.3e-09 35.5 0.6 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KII74297.1 - 4.4e-10 38.0 3.6 0.021 14.9 0.5 4.9 3 1 1 4 4 4 3 Leucine rich repeat LRR_9 PF14580.1 KII74297.1 - 6.1e-10 38.9 0.0 8.2e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.1 KII74297.1 - 1.2e-09 37.2 2.6 0.016 15.1 0.2 4.7 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.28 KII74297.1 - 2.2e-09 36.0 5.3 0.036 14.0 0.2 4.8 5 0 0 5 5 5 4 Leucine Rich Repeat LRR_8 PF13855.1 KII74297.1 - 2.3e-09 36.8 11.9 1.5e-06 27.8 2.4 2.8 1 1 2 3 3 3 3 Leucine rich repeat LCM PF04072.9 KII74298.1 - 0.12 11.9 0.0 14 5.1 0.0 2.1 2 0 0 2 2 2 0 Leucine carboxyl methyltransferase Cys_rich_FGFR PF00839.12 KII74298.1 - 0.47 10.4 2.9 19 5.2 0.3 2.3 2 0 0 2 2 2 0 Cysteine rich repeat Caldesmon PF02029.10 KII74299.1 - 0.057 11.8 5.2 0.064 11.6 3.6 1.0 1 0 0 1 1 1 0 Caldesmon Not3 PF04065.10 KII74299.1 - 0.18 11.0 8.0 0.24 10.6 5.6 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DUF4565 PF15127.1 KII74300.1 - 0.089 13.1 0.1 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4565) Mvb12 PF09452.5 KII74302.1 - 0.084 13.0 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 Pacs-1 PF10254.4 KII74303.1 - 8.1e-13 47.7 1.0 9.2e-13 47.5 0.7 1.0 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein BTG PF07742.7 KII74304.1 - 2.4e-18 65.7 0.0 3.4e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 BTG family C2 PF00168.25 KII74305.1 - 0.0047 16.7 0.0 0.0061 16.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain Fer2_3 PF13085.1 KII74306.1 - 2.8e-32 110.7 0.0 4.3e-32 110.2 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.1 KII74306.1 - 3.1e-10 39.9 2.8 3.1e-10 39.9 1.9 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.1 KII74306.1 - 9.6e-09 35.4 3.9 9.6e-09 35.4 2.7 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 KII74306.1 - 3.8e-05 24.0 5.5 0.00013 22.3 0.4 2.6 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_7 PF12838.2 KII74306.1 - 4.2e-05 23.8 2.4 4.2e-05 23.8 1.6 2.7 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 KII74306.1 - 0.00054 19.6 5.1 0.00054 19.6 3.5 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 KII74306.1 - 0.0015 18.7 9.1 0.044 14.0 4.8 3.0 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer2 PF00111.22 KII74306.1 - 0.023 14.4 1.8 0.023 14.4 1.2 2.1 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain CTD_bind PF04818.8 KII74307.1 - 0.095 12.9 0.0 0.53 10.5 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase II-binding domain. Syntaxin-6_N PF09177.6 KII74307.1 - 0.12 12.8 0.0 0.83 10.0 0.0 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Mtp PF03821.11 KII74309.1 - 0.0038 16.6 4.4 0.006 16.0 3.1 1.2 1 0 0 1 1 1 1 Golgi 4-transmembrane spanning transporter Shisa PF13908.1 KII74309.1 - 0.0046 17.1 1.1 0.0073 16.5 0.8 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.1 KII74309.1 - 0.0087 15.7 0.5 0.015 15.0 0.3 1.3 1 0 0 1 1 1 1 TMEM154 protein family AJAP1_PANP_C PF15298.1 KII74309.1 - 0.036 13.9 0.3 0.06 13.2 0.2 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF2293 PF10056.4 KII74309.1 - 0.063 13.2 0.1 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2293) Adeno_E4_34 PF04528.8 KII74309.1 - 0.096 12.2 2.6 0.22 11.1 0.0 2.2 2 0 0 2 2 2 0 Adenovirus early E4 34 kDa protein conserved region rve PF00665.21 KII74310.1 - 3.5e-25 88.4 0.0 7.1e-25 87.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74310.1 - 0.0012 18.2 0.0 0.0036 16.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII74310.1 - 0.0023 17.9 0.1 0.0068 16.3 0.0 1.8 2 0 0 2 2 2 1 DDE domain RVT_1 PF00078.22 KII74311.1 - 1.1e-21 77.2 0.1 2.2e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII74311.1 - 4.5e-06 26.5 0.0 1.1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII74311.1 - 0.00038 20.2 3.3 0.00038 20.2 2.3 2.8 2 0 0 2 2 2 1 Zinc knuckle Asp_protease_2 PF13650.1 KII74311.1 - 0.0012 19.2 0.0 0.0027 18.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII74311.1 - 0.052 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII74311.1 - 0.39 10.4 9.6 3 7.5 0.9 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 KII74311.1 - 0.62 9.8 10.0 0.12 12.1 1.1 2.6 1 1 1 2 2 2 0 Zinc knuckle A2L_zn_ribbon PF08792.5 KII74312.1 - 0.096 12.1 0.6 0.17 11.3 0.4 1.4 1 0 0 1 1 1 0 A2L zinc ribbon domain rve PF00665.21 KII74313.1 - 2.3e-16 59.9 0.0 5.4e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74313.1 - 4.1e-05 23.0 0.0 0.0001 21.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain FG-GAP PF01839.18 KII74315.1 - 0.33 10.7 0.0 0.33 10.7 0.0 2.4 2 0 0 2 2 2 0 FG-GAP repeat DUF4445 PF14574.1 KII74319.1 - 0.11 10.6 0.0 0.14 10.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4445) CNH PF00780.17 KII74320.1 - 0.084 12.2 0.4 0.12 11.7 0.0 1.4 2 0 0 2 2 2 0 CNH domain DUF1602 PF07673.9 KII74320.1 - 0.18 11.2 1.9 0.41 10.1 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1602) CHCH PF06747.8 KII74321.1 - 5e-05 23.1 0.8 9e-05 22.2 0.6 1.5 1 0 0 1 1 1 1 CHCH domain DUF1903 PF08991.5 KII74321.1 - 0.19 11.8 1.6 0.31 11.2 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1903) UPF0203 PF05254.7 KII74321.1 - 0.58 10.0 4.9 1.8 8.4 0.3 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) HEAT PF02985.17 KII74322.1 - 8.7e-06 25.3 0.6 0.14 12.3 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.1 KII74322.1 - 0.0012 19.1 0.5 0.037 14.3 0.0 2.4 2 1 1 3 3 3 2 HEAT repeats TIP120 PF08623.5 KII74322.1 - 0.0047 16.5 0.0 0.016 14.7 0.0 1.9 2 1 0 2 2 2 1 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.1 KII74322.1 - 0.011 16.2 0.2 1.3 9.6 0.0 2.9 1 1 1 2 2 2 0 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KII74322.1 - 0.051 13.9 0.1 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DDE_Tnp_IS1595 PF12762.2 KII74324.1 - 1e-10 41.6 0.0 3.5e-10 39.9 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain RVT_1 PF00078.22 KII74331.1 - 0.0092 15.3 0.0 0.015 14.6 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_3 PF13358.1 KII74333.1 - 5.5e-11 42.4 0.1 0.00016 21.4 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease AAT PF03417.11 KII74333.1 - 0.012 15.0 0.1 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase P5-ATPase PF12409.3 KII74333.1 - 0.054 13.3 0.1 0.075 12.8 0.1 1.2 1 0 0 1 1 1 0 P5-type ATPase cation transporter 2OG-FeII_Oxy_3 PF13640.1 KII74334.1 - 1.3e-06 28.8 0.6 1.1e-05 25.8 0.0 2.7 2 2 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KII74334.1 - 0.0022 17.5 0.1 0.0093 15.5 0.0 2.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_6 PF13405.1 KII74334.1 - 0.1 12.5 0.6 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain DDE_1 PF03184.14 KII74338.1 - 5.3e-07 29.0 0.1 6.3e-07 28.7 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII74339.1 - 0.0074 15.4 0.1 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease UK PF02512.9 KII74339.1 - 0.086 13.2 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Virulence determinant LepA_C PF06421.7 KII74340.1 - 0.051 13.4 0.4 0.071 13.0 0.3 1.2 1 0 0 1 1 1 0 GTP-binding protein LepA C-terminus Imm36 PF15597.1 KII74343.1 - 0.092 12.9 0.1 0.15 12.1 0.1 1.4 1 1 0 1 1 1 0 Immunity protein 36 VirE1 PF12189.3 KII74343.1 - 0.1 12.7 1.8 0.13 12.4 0.6 1.7 2 0 0 2 2 2 0 Single-strand DNA-binding protein DUF3256 PF11644.3 KII74344.1 - 0.095 12.1 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3256) Thymidylat_synt PF00303.14 KII74348.1 - 3e-123 410.0 0.0 3.4e-123 409.9 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase HD_3 PF13023.1 KII74349.1 - 2e-25 89.4 0.3 2.5e-25 89.1 0.2 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 KII74349.1 - 0.047 13.6 0.1 0.26 11.3 0.1 2.0 1 1 0 1 1 1 0 HD domain Rep_3 PF01051.16 KII74350.1 - 0.041 13.4 2.6 0.053 13.1 1.8 1.3 1 1 0 1 1 1 0 Initiator Replication protein WD40 PF00400.27 KII74351.1 - 1.1e-07 31.4 0.3 0.00091 19.0 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.27 KII74352.1 - 1.1 9.3 3.4 36 4.4 0.0 4.0 5 0 0 5 5 5 0 WD domain, G-beta repeat PFK PF00365.15 KII74353.1 - 8.6e-43 146.3 0.6 1e-42 146.0 0.4 1.0 1 0 0 1 1 1 1 Phosphofructokinase PFK PF00365.15 KII74354.1 - 1.5e-99 332.5 0.0 5.2e-60 202.8 0.1 2.1 2 0 0 2 2 2 2 Phosphofructokinase TMCO5 PF14992.1 KII74356.1 - 0.019 14.1 1.7 0.023 13.8 1.2 1.1 1 0 0 1 1 1 0 TMCO5 family NAD4L PF06235.6 KII74356.1 - 0.033 13.9 3.7 0.036 13.8 1.5 1.8 2 0 0 2 2 2 0 NADH dehydrogenase subunit 4L (NAD4L) DUF912 PF06024.7 KII74356.1 - 0.038 14.0 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PsbH PF00737.15 KII74356.1 - 0.8 9.3 3.3 1.4 8.5 2.3 1.3 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein PNMA PF14893.1 KII74357.1 - 0.0055 15.7 0.0 0.0055 15.7 0.0 1.1 1 0 0 1 1 1 1 PNMA DUF257 PF03192.8 KII74357.1 - 0.051 12.8 0.0 0.092 12.0 0.0 1.3 1 0 0 1 1 1 0 Pyrococcus protein of unknown function, DUF257 rve PF00665.21 KII74358.1 - 5.5e-23 81.3 0.0 1.1e-22 80.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII74358.1 - 1.6e-17 63.5 0.0 4.6e-17 62.0 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.1 KII74358.1 - 2e-06 27.5 0.0 3.9e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII74358.1 - 5.2e-05 23.6 0.0 0.00012 22.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII74358.1 - 0.00017 21.4 0.0 0.00048 20.0 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII74358.1 - 0.002 17.6 0.0 0.0046 16.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII74358.1 - 0.0023 17.7 3.9 0.0023 17.7 2.7 2.9 2 0 0 2 2 2 1 Zinc knuckle DUF3565 PF12088.3 KII74359.1 - 0.13 12.0 0.0 0.7 9.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3565) Rib_5-P_isom_A PF06026.9 KII74360.1 - 0.12 11.6 0.9 0.18 11.0 0.6 1.2 1 0 0 1 1 1 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) MULE PF10551.4 KII74361.1 - 0.011 15.8 0.1 0.052 13.7 0.0 2.1 2 0 0 2 2 2 0 MULE transposase domain Mating_C PF12737.2 KII74363.1 - 0.025 13.4 8.0 0.03 13.2 5.5 1.0 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 Gag_p12 PF01141.13 KII74363.1 - 0.073 13.2 0.5 0.18 11.9 0.0 2.0 1 1 1 2 2 2 0 Gag polyprotein, inner coat protein p12 DDE_3 PF13358.1 KII74365.1 - 6.7e-16 58.3 0.1 7.4e-16 58.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KII74366.1 - 1.1e-05 25.5 0.0 1.4e-05 25.2 0.0 1.3 1 1 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII74366.1 - 6.7e-05 22.4 0.1 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.13 KII74366.1 - 0.0016 18.1 0.3 0.0019 17.8 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain EF-hand_8 PF13833.1 KII74366.1 - 0.0092 15.5 0.0 3.5 7.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair HTH_Crp_2 PF13545.1 KII74366.1 - 0.031 14.0 0.1 0.078 12.7 0.1 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Baculo_LEF5 PF04838.7 KII74366.1 - 0.073 12.8 0.1 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 EF-hand_7 PF13499.1 KII74366.1 - 0.12 12.5 0.2 0.24 11.5 0.1 1.7 1 1 0 1 1 1 0 EF-hand domain pair DUF3284 PF11687.3 KII74369.1 - 0.018 14.7 0.3 0.022 14.4 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3284) rve PF00665.21 KII74371.1 - 2.9e-15 56.4 0.1 9.8e-15 54.7 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Glyco_hydro_101 PF12905.2 KII74375.1 - 0.0022 16.7 0.1 0.0023 16.6 0.1 1.1 1 0 0 1 1 1 1 Endo-alpha-N-acetylgalactosaminidase DUF1759 PF03564.10 KII74376.1 - 9.1e-05 22.3 0.1 0.00013 21.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) PNMA PF14893.1 KII74376.1 - 0.0039 16.2 0.1 0.006 15.6 0.1 1.2 1 0 0 1 1 1 1 PNMA SpoU_methylas_C PF12105.3 KII74376.1 - 0.075 12.5 0.0 0.29 10.7 0.0 1.9 2 0 0 2 2 2 0 SpoU, rRNA methylase, C-terminal Asp_protease_2 PF13650.1 KII74377.1 - 6.6e-05 23.3 0.0 8.7e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 KII74377.1 - 0.00048 20.0 0.0 0.00068 19.5 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII74377.1 - 0.021 14.3 0.0 3.9 7.0 0.0 2.0 2 0 0 2 2 2 0 Aspartyl protease RE_NgoPII PF09521.5 KII74377.1 - 0.024 13.4 0.1 0.024 13.4 0.0 1.1 1 0 0 1 1 1 0 NgoPII restriction endonuclease gag-asp_proteas PF13975.1 KII74377.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RNA_ligase PF09414.5 KII74378.1 - 0.073 12.8 0.1 0.077 12.7 0.1 1.1 1 0 0 1 1 1 0 RNA ligase rve PF00665.21 KII74379.1 - 8.8e-21 74.2 0.0 2.1e-20 73.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII74379.1 - 5e-17 61.9 0.0 1.5e-16 60.4 0.0 1.9 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.1 KII74379.1 - 1.4e-05 24.4 0.3 9.8e-05 21.8 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.18 KII74379.1 - 4 7.5 16.5 0.28 11.1 4.6 2.9 2 0 0 2 2 2 0 Zinc knuckle AAA_11 PF13086.1 KII74383.1 - 1.5e-33 116.3 0.6 3.7e-32 111.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 KII74383.1 - 6.6e-29 100.7 0.1 5e-28 97.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KII74383.1 - 1.6e-09 37.3 0.0 3.6e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KII74383.1 - 3.7e-05 23.3 0.0 0.057 13.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain DEAD PF00270.24 KII74383.1 - 5.5e-05 22.7 1.2 0.00013 21.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 KII74383.1 - 0.00013 21.8 0.0 0.00044 20.1 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_25 PF13481.1 KII74383.1 - 0.0044 16.4 0.0 0.01 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.12 KII74383.1 - 0.007 15.2 0.0 0.017 13.9 0.0 1.6 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA PF00004.24 KII74383.1 - 0.0085 16.2 0.0 0.03 14.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KII74383.1 - 0.044 13.4 0.2 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) UvrD_C_2 PF13538.1 KII74383.1 - 0.045 13.8 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF2075 PF09848.4 KII74383.1 - 0.057 12.3 0.0 0.057 12.3 0.0 2.3 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Cnl2_NKP2 PF09447.5 KII74383.1 - 0.089 12.4 0.1 0.089 12.4 0.1 3.2 3 0 0 3 3 3 0 Cnl2/NKP2 family protein AAA_33 PF13671.1 KII74383.1 - 0.13 12.1 0.0 0.35 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KII74383.1 - 0.27 12.0 2.0 1.5 9.6 0.0 3.2 3 1 1 4 4 2 0 AAA domain PspA_IM30 PF04012.7 KII74384.1 - 0.59 9.4 14.4 0.11 11.8 1.6 2.9 3 0 0 3 3 3 0 PspA/IM30 family NUDIX_2 PF13869.1 KII74385.1 - 2e-68 229.4 0.1 2.3e-68 229.2 0.1 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.23 KII74385.1 - 0.1 12.2 0.0 0.17 11.4 0.0 1.6 1 1 0 1 1 1 0 NUDIX domain DSPn PF14671.1 KII74386.1 - 0.071 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Omega-toxin PF06357.6 KII74386.1 - 0.13 11.8 0.1 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Omega-atracotoxin DUF1874 PF08960.5 KII74387.1 - 0.084 12.6 0.2 0.16 11.7 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1874) WD40 PF00400.27 KII74388.1 - 1.4e-21 75.4 15.1 1.7e-06 27.6 0.7 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup88 PF10168.4 KII74388.1 - 0.067 11.0 0.0 0.088 10.6 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore component DDE_Tnp_IS1595 PF12762.2 KII74389.1 - 5e-14 52.4 0.1 5.5e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain tRNA_synt_1c_R1 PF04558.10 KII74390.1 - 3.4e-23 81.9 0.1 5e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 Nrf1_DNA-bind PF10491.4 KII74391.1 - 1.4e-86 289.0 0.2 3.1e-86 287.9 0.1 1.6 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 DGCR6 PF07324.6 KII74393.1 - 0.0099 15.3 11.1 0.015 14.8 7.7 1.4 1 1 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein DUF1943 PF09172.6 KII74393.1 - 0.039 12.8 1.0 0.047 12.5 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) DUF2458 PF10454.4 KII74393.1 - 0.045 13.6 12.6 0.065 13.1 2.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2458) IncA PF04156.9 KII74393.1 - 6.6 6.2 9.7 8.3 5.9 6.7 1.2 1 0 0 1 1 1 0 IncA protein DUF972 PF06156.8 KII74393.1 - 9.2 6.6 10.4 1.8e+02 2.4 7.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) RasGEF PF00617.14 KII74394.1 - 6.2e-42 143.4 0.6 1.5e-41 142.2 0.4 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 KII74394.1 - 2.9e-09 36.9 0.3 2.9e-09 36.9 0.2 3.0 3 1 0 3 3 3 1 RasGEF N-terminal motif DEAD PF00270.24 KII74395.1 - 2.4e-39 134.5 0.0 9.2e-39 132.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KII74395.1 - 1.7e-27 95.1 0.1 1.3e-26 92.2 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.10 KII74395.1 - 0.022 14.6 0.6 0.063 13.1 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit NARP1 PF12569.3 KII74396.1 - 2.4e-43 148.6 5.1 2.4e-43 148.6 3.5 2.8 2 1 1 3 3 3 1 NMDA receptor-regulated protein 1 TPR_11 PF13414.1 KII74396.1 - 6.8e-10 38.4 7.2 0.011 15.3 0.0 5.9 6 1 0 6 6 6 2 TPR repeat TPR_2 PF07719.12 KII74396.1 - 8e-09 34.7 12.0 0.0029 17.4 0.0 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat Apc3 PF12895.2 KII74396.1 - 0.00023 21.2 11.5 0.46 10.6 0.6 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KII74396.1 - 0.0013 19.0 2.0 15 6.0 0.1 5.2 5 1 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 KII74396.1 - 0.024 14.4 0.5 2.9 7.9 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KII74396.1 - 0.033 14.8 0.0 39 5.2 0.0 5.0 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.1 KII74396.1 - 0.058 13.6 0.3 68 4.0 0.0 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 KII74396.1 - 0.072 13.7 0.0 21 5.9 0.0 4.1 5 1 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KII74396.1 - 0.42 10.5 10.0 41 4.1 0.0 5.3 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.23 KII74396.1 - 4.5 7.0 22.7 3.1 7.5 0.1 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat Sod_Cu PF00080.15 KII74398.1 - 0.13 12.3 0.0 13 5.8 0.0 3.0 3 0 0 3 3 3 0 Copper/zinc superoxide dismutase (SODC) Ldl_recept_a PF00057.13 KII74399.1 - 2.3e-35 120.1 114.1 9.6e-10 38.2 7.9 6.9 6 1 1 7 7 7 6 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.1 KII74399.1 - 5.1e-05 23.3 4.6 5.1e-05 23.3 3.2 5.3 6 1 0 6 6 6 1 Coagulation Factor Xa inhibitory site CagY_I PF14585.1 KII74399.1 - 0.035 14.0 0.1 0.078 12.9 0.1 1.5 1 0 0 1 1 1 0 CagY type 1 repeat Pep3_Vps18 PF05131.9 KII74400.1 - 0.0011 18.4 0.6 0.89 8.9 0.0 2.3 1 1 1 2 2 2 2 Pep3/Vps18/deep orange family DUF1565 PF07602.6 KII74400.1 - 0.15 11.1 0.7 0.22 10.6 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1565) DUF2172 PF09940.4 KII74402.1 - 0.076 11.3 0.2 0.11 10.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2172) RVT_1 PF00078.22 KII74403.1 - 1.7e-25 89.6 0.0 4e-25 88.4 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII74403.1 - 5.5e-25 87.8 0.0 1.4e-24 86.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.18 KII74403.1 - 4.4e-05 23.2 1.3 0.0001 22.0 0.9 1.7 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.15 KII74403.1 - 0.00036 20.3 0.0 0.004 17.0 0.0 2.4 2 0 0 2 2 2 1 Retroviral aspartyl protease rve_3 PF13683.1 KII74403.1 - 0.027 13.9 0.0 0.075 12.5 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII74403.1 - 0.056 13.4 0.0 0.35 10.8 0.0 2.3 2 0 0 2 2 2 0 DDE domain HTH_23 PF13384.1 KII74406.1 - 7e-08 31.8 0.0 1.2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 KII74406.1 - 2.2e-07 30.9 0.0 2.5e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 KII74406.1 - 2.5e-06 27.3 0.1 6e-06 26.1 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_38 PF13936.1 KII74406.1 - 2e-05 24.0 0.0 8.4e-05 22.0 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Crp_2 PF13545.1 KII74406.1 - 0.00033 20.4 0.0 0.00049 19.8 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain PAX PF00292.13 KII74406.1 - 0.00033 20.3 0.0 0.00037 20.2 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain TrmB PF01978.14 KII74406.1 - 0.014 15.0 0.2 0.026 14.2 0.0 1.6 2 0 0 2 2 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 KII74406.1 - 0.015 14.9 0.4 0.11 12.2 0.3 2.1 1 1 0 1 1 1 0 MarR family HTH_Tnp_IS630 PF01710.11 KII74406.1 - 0.022 14.4 0.3 0.025 14.2 0.2 1.2 1 0 0 1 1 1 0 Transposase GerE PF00196.14 KII74406.1 - 0.029 13.7 0.2 0.044 13.0 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_11 PF08279.7 KII74406.1 - 0.045 13.3 0.2 0.065 12.8 0.2 1.3 1 0 0 1 1 1 0 HTH domain HTH_7 PF02796.10 KII74406.1 - 0.047 13.5 0.6 0.094 12.5 0.1 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_Tnp_1 PF01527.15 KII74406.1 - 0.047 13.6 0.1 0.069 13.1 0.0 1.6 1 1 0 1 1 1 0 Transposase Sigma70_r4 PF04545.11 KII74406.1 - 0.083 12.2 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 Sigma70_r4_2 PF08281.7 KII74406.1 - 0.088 12.2 0.1 0.17 11.3 0.0 1.5 2 0 0 2 2 1 0 Sigma-70, region 4 Nup35_RRM PF05172.8 KII74406.1 - 0.096 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Bacteroid_pep PF14406.1 KII74407.1 - 0.031 14.4 0.1 0.11 12.6 0.1 1.9 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Bacteroidetes GET2 PF08690.5 KII74407.1 - 0.17 11.0 5.9 0.24 10.5 4.1 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Bacillus_HBL PF05791.6 KII74413.1 - 0.026 13.8 1.2 0.033 13.5 0.8 1.1 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Spindle_Spc25 PF08234.7 KII74413.1 - 0.036 14.0 0.1 0.093 12.7 0.0 1.7 1 0 0 1 1 1 0 Chromosome segregation protein Spc25 DUF43 PF01861.11 KII74413.1 - 0.078 11.9 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF43 DDE_3 PF13358.1 KII74414.1 - 0.0005 19.8 0.0 0.00074 19.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Ldl_recept_a PF00057.13 KII74417.1 - 1.9e-22 78.8 50.2 8.4e-11 41.5 10.8 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A IgaA PF07095.6 KII74417.1 - 0.087 10.5 1.0 0.12 10.0 0.7 1.2 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA Pneumo_M2 PF07380.6 KII74418.1 - 0.86 9.6 6.0 0.58 10.1 1.1 2.3 1 1 0 2 2 2 0 Pneumovirus M2 protein NTNH_C PF08470.5 KII74419.1 - 0.094 12.3 0.2 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal PNK3P PF08645.6 KII74420.1 - 0.059 12.8 0.2 0.079 12.3 0.2 1.3 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase GET2 PF08690.5 KII74421.1 - 1.5 7.9 6.5 2.2 7.4 4.5 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 VP4_haemagglut PF00426.13 KII74422.1 - 0.0026 15.8 8.1 0.0026 15.8 5.6 1.6 1 1 0 1 1 1 1 Outer Capsid protein VP4 (Hemagglutinin) Mitofilin PF09731.4 KII74422.1 - 0.087 11.4 10.7 0.099 11.2 7.4 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein GAGA_bind PF06217.7 KII74422.1 - 0.095 12.6 6.8 0.11 12.4 4.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Trypan_PARP PF05887.6 KII74422.1 - 2.1 8.1 6.6 3.1 7.6 4.5 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Macoilin PF09726.4 KII74422.1 - 2.3 6.3 14.2 2.7 6.1 9.9 1.1 1 0 0 1 1 1 0 Transmembrane protein RR_TM4-6 PF06459.7 KII74422.1 - 3.3 7.5 9.3 3.9 7.2 6.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.8 KII74423.1 - 0.25 11.1 6.8 0.32 10.8 4.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CcmH PF03918.9 KII74425.1 - 0.076 12.0 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein DUF3953 PF13129.1 KII74425.1 - 0.35 10.5 5.9 0.74 9.4 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) MFS_1 PF07690.11 KII74426.1 - 7.4e-35 120.2 26.9 1.1e-33 116.4 16.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Claudin_2 PF13903.1 KII74426.1 - 0.047 13.3 13.8 0.21 11.2 0.0 3.9 3 1 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction DUF1469 PF07332.6 KII74426.1 - 2.3 7.9 4.2 0.93 9.2 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1469) Rifin_STEVOR PF02009.11 KII74427.1 - 0.022 14.4 0.6 0.022 14.4 0.4 1.6 2 0 0 2 2 2 0 Rifin/stevor family DUF3377 PF11857.3 KII74427.1 - 0.048 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) ALMT PF11744.3 KII74429.1 - 0.05 12.2 8.3 0.063 11.9 5.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Nop14 PF04147.7 KII74429.1 - 6 4.6 18.0 6.9 4.4 12.5 1.1 1 0 0 1 1 1 0 Nop14-like family FLYWCH PF04500.11 KII74433.1 - 3.9e-12 45.8 0.7 7.1e-12 45.0 0.1 1.8 2 0 0 2 2 2 1 FLYWCH zinc finger domain MULE PF10551.4 KII74433.1 - 1.8e-06 28.0 0.0 1.2e-05 25.3 0.0 2.3 2 0 0 2 2 2 1 MULE transposase domain DUF948 PF06103.6 KII74434.1 - 0.00077 19.2 0.1 0.0023 17.7 0.1 1.8 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Prefoldin PF02996.12 KII74434.1 - 0.42 10.2 4.0 0.28 10.8 1.2 1.8 2 0 0 2 2 2 0 Prefoldin subunit DUF4372 PF14294.1 KII74435.1 - 0.13 12.2 0.1 6.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4372) PagP PF07017.6 KII74436.1 - 7.3e-63 210.2 13.8 2.2e-61 205.4 9.6 2.0 1 1 0 1 1 1 1 Antimicrobial peptide resistance and lipid A acylation protein PagP LysR_substrate PF03466.15 KII74437.1 - 1e-07 31.3 0.0 1.2e-07 31.1 0.0 1.0 1 0 0 1 1 1 1 LysR substrate binding domain Pkinase PF00069.20 KII74438.1 - 1.5e-34 119.3 0.0 1.8e-34 119.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII74438.1 - 1.9e-15 56.6 0.0 3.3e-15 55.8 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Transposase_21 PF02992.9 KII74438.1 - 0.093 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Transposase family tnp2 SMC_Nse1 PF07574.8 KII74438.1 - 0.15 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex PhoD PF09423.5 KII74439.1 - 0.00095 17.8 0.0 0.0018 16.9 0.0 1.4 1 1 0 1 1 1 1 PhoD-like phosphatase PDR_assoc PF08370.6 KII74439.1 - 0.11 12.0 0.2 0.21 11.1 0.1 1.5 1 0 0 1 1 1 0 Plant PDR ABC transporter associated Metallophos_C PF14008.1 KII74440.1 - 1.6e-11 44.0 0.0 2.7e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C UPF0233 PF06781.7 KII74441.1 - 0.086 12.4 0.8 0.94 9.1 0.0 3.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0233) PPTA PF01239.17 KII74442.1 - 0.051 12.9 0.2 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat Kelch_3 PF13415.1 KII74443.1 - 0.073 13.2 0.1 0.51 10.5 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.1 KII74443.1 - 0.14 12.3 0.3 1.1 9.5 0.1 2.3 2 0 0 2 2 2 0 Kelch motif AT_hook PF02178.14 KII74444.1 - 0.071 12.8 4.0 0.071 12.8 1.0 2.2 2 0 0 2 2 2 0 AT hook motif Kelch_6 PF13964.1 KII74445.1 - 3e-06 27.1 3.1 0.00034 20.6 0.3 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII74445.1 - 1.9e-05 24.1 0.5 0.0016 17.9 0.1 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII74445.1 - 0.00091 18.9 1.3 0.031 14.0 0.4 2.3 2 0 0 2 2 2 1 Kelch motif zf-H2C2_2 PF13465.1 KII74449.1 - 3.8e-13 49.0 23.5 6.1e-09 35.7 1.0 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII74449.1 - 2.9e-12 46.0 16.1 0.00028 21.0 0.7 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 KII74449.1 - 7.7e-12 44.8 23.5 0.00022 21.3 0.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-LYAR PF08790.6 KII74449.1 - 0.0034 17.0 2.6 0.0034 17.0 1.8 2.1 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger LIM PF00412.17 KII74449.1 - 0.47 10.5 11.5 0.63 10.1 1.8 2.9 1 1 2 3 3 3 0 LIM domain SIR2 PF02146.12 KII74449.1 - 1.7 8.3 6.1 4.2 7.0 4.2 1.8 1 1 0 1 1 1 0 Sir2 family zf-met PF12874.2 KII74449.1 - 2 8.7 9.0 3.2 8.0 1.7 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type AATF-Che1 PF13339.1 KII74451.1 - 0.1 12.7 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor Rad9 PF04139.8 KII74456.1 - 0.046 12.8 0.0 0.092 11.8 0.0 1.4 1 0 0 1 1 1 0 Rad9 NARP1 PF12569.3 KII74457.1 - 0.072 11.8 0.0 0.077 11.7 0.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FolB PF02152.13 KII74457.1 - 0.13 12.4 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Dihydroneopterin aldolase Hira PF07569.6 KII74458.1 - 1.9e-19 69.7 1.7 3.5e-17 62.3 0.6 2.7 1 1 1 2 2 2 1 TUP1-like enhancer of split HIRA_B PF09453.5 KII74458.1 - 0.00013 21.3 0.3 0.00048 19.6 0.2 2.0 1 0 0 1 1 1 1 HIRA B motif Suf PF05843.9 KII74458.1 - 5.6 6.6 9.7 0.3 10.7 0.5 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DDE_3 PF13358.1 KII74460.1 - 2.9e-07 30.3 0.2 1.9e-06 27.7 0.1 2.0 1 1 1 2 2 2 1 DDE superfamily endonuclease IF4E PF01652.13 KII74462.1 - 1.5e-35 122.1 0.1 1.8e-35 121.8 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF1965 PF09248.5 KII74463.1 - 0.059 13.2 0.6 0.097 12.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) PH PF00169.24 KII74464.1 - 1e-15 57.8 0.2 1.2e-15 57.6 0.1 1.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 KII74464.1 - 1.2e-05 25.4 0.5 0.00055 20.1 0.4 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.1 KII74464.1 - 0.078 13.0 0.0 0.11 12.5 0.0 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain MULE PF10551.4 KII74465.1 - 0.024 14.7 0.1 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 MULE transposase domain Attachment_P66 PF11263.3 KII74466.1 - 0.023 13.7 0.0 0.032 13.2 0.0 1.3 1 1 0 1 1 1 0 Borrelia burgdorferi attachment protein P66 WD40 PF00400.27 KII74467.1 - 2e-11 43.3 1.2 2.7e-06 27.0 0.2 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat PH_BEACH PF14844.1 KII74467.1 - 7.1e-05 22.5 0.4 0.00023 20.9 0.3 1.9 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Ribosomal_S8 PF00410.14 KII74468.1 - 3.5e-26 91.5 0.1 4.5e-26 91.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Metallophos PF00149.23 KII74470.1 - 5.6e-12 45.4 0.0 7e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase VitD-bind_III PF09164.5 KII74470.1 - 0.029 13.9 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Vitamin D binding protein, domain III RVT_1 PF00078.22 KII74471.1 - 0.048 12.9 0.2 0.069 12.5 0.1 1.5 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) PALP PF00291.20 KII74472.1 - 3.7e-29 101.9 0.0 4.7e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Usher PF00577.15 KII74473.1 - 1.9e-190 634.2 21.3 2.4e-190 633.9 14.7 1.0 1 0 0 1 1 1 1 Outer membrane usher protein PapC_N PF13954.1 KII74473.1 - 8e-24 83.8 0.0 1.7e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 PapC N-terminal domain PapD_N PF00345.15 KII74474.1 - 2.9e-42 143.2 0.0 4.7e-42 142.6 0.0 1.3 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain PapD_C PF02753.12 KII74474.1 - 1.6e-19 69.4 0.7 3.5e-19 68.3 0.2 1.8 2 0 0 2 2 2 1 Pili assembly chaperone PapD, C-terminal domain Fimbrial PF00419.15 KII74475.1 - 1.9e-15 57.3 9.7 2.3e-15 57.1 6.7 1.1 1 0 0 1 1 1 1 Fimbrial protein Ribonuc_L-PSP PF01042.16 KII74476.1 - 7.7e-09 35.3 0.0 8.5e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP ApoC-I PF04691.7 KII74476.1 - 0.13 11.9 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) Trans_reg_C PF00486.23 KII74477.1 - 1.2e-09 37.9 0.0 2e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Lipoprotein_19 PF13617.1 KII74477.1 - 0.03 13.9 0.0 0.076 12.6 0.0 1.6 1 0 0 1 1 1 0 YnbE-like lipoprotein GerE PF00196.14 KII74479.1 - 1.3e-06 27.6 0.3 2.1e-06 26.9 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family dCMP_cyt_deam_1 PF00383.17 KII74480.1 - 6.2e-20 70.7 0.0 1.2e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.1 KII74480.1 - 0.028 14.0 0.2 0.068 12.8 0.1 1.6 2 0 0 2 2 2 0 MafB19-like deaminase Bd3614-deam PF14439.1 KII74480.1 - 0.15 11.8 0.7 1.1 9.1 0.5 2.2 1 1 0 1 1 1 0 Bd3614-like deaminase PHP PF02811.14 KII74481.1 - 1.6e-06 28.0 0.0 3.4e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 PHP domain DHDPS PF00701.17 KII74481.1 - 0.015 13.9 0.0 0.022 13.3 0.0 1.2 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Abhydrolase_3 PF07859.8 KII74482.1 - 3.7e-40 137.7 0.0 2.7e-28 98.9 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold DUF2424 PF10340.4 KII74482.1 - 1.8e-09 36.7 0.0 3.1e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 KII74482.1 - 2e-06 27.6 0.0 2.6e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF554 PF04474.7 KII74483.1 - 2.3e-74 249.3 22.0 2.6e-74 249.1 15.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF554) ATPase_gene1 PF09527.5 KII74483.1 - 3.7 7.4 10.6 0.29 10.9 0.4 3.2 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit (ATPase_gene1) CLTH PF10607.4 KII74484.1 - 1.4e-06 28.0 0.0 1.8e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain DUF2931 PF11153.3 KII74486.1 - 0.047 13.0 0.1 0.078 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2931) Proteasome PF00227.21 KII74488.1 - 1.5e-43 148.3 1.0 1.7e-43 148.1 0.7 1.0 1 0 0 1 1 1 1 Proteasome subunit SIS PF01380.17 KII74489.1 - 1.7e-38 131.1 0.2 8.3e-25 86.9 0.0 2.2 2 0 0 2 2 2 2 SIS domain SIS_2 PF13580.1 KII74489.1 - 0.00085 19.0 0.0 0.003 17.2 0.0 1.9 2 0 0 2 2 2 1 SIS domain SIS PF01380.17 KII74490.1 - 0.046 13.3 0.0 0.059 12.9 0.0 1.2 1 0 0 1 1 1 0 SIS domain SIS PF01380.17 KII74491.1 - 1.1e-12 47.6 0.0 1.3e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.1 KII74491.1 - 9.4e-05 22.1 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 SIS domain CPSase_L_chain PF00289.17 KII74491.1 - 0.052 13.6 0.0 0.078 13.0 0.0 1.4 1 1 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, N-terminal domain UBA PF00627.26 KII74492.1 - 4.5e-08 32.6 0.2 4.5e-08 32.6 0.1 2.3 3 0 0 3 3 3 1 UBA/TS-N domain ubiquitin PF00240.18 KII74492.1 - 1.7e-05 24.0 0.0 4.3e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.1 KII74492.1 - 0.0027 17.5 0.2 0.0058 16.4 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.3 KII74492.1 - 0.069 12.8 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF3672 PF12421.3 KII74494.1 - 0.086 12.9 0.2 0.1 12.7 0.1 1.2 1 0 0 1 1 1 0 Fibronectin type III protein OGG_N PF07934.7 KII74494.1 - 0.087 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain zf-CpG_bind_C PF12269.3 KII74495.1 - 2.2e-28 99.3 4.5 3e-28 98.9 3.1 1.2 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain DUF1666 PF07891.7 KII74495.1 - 0.49 9.7 7.9 0.59 9.4 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1666) DUF3347 PF11827.3 KII74495.1 - 0.5 10.3 9.9 0.67 9.9 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Cucumo_2B PF03263.8 KII74495.1 - 1.7 8.9 4.8 0.3 11.3 0.5 1.9 2 1 0 2 2 2 0 Cucumovirus protein 2B Hexapep PF00132.19 KII74498.1 - 5.5e-08 31.9 8.6 0.0065 15.9 1.1 4.6 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KII74498.1 - 0.28 10.7 9.5 0.5 9.9 2.3 3.3 3 1 1 4 4 4 0 Hexapeptide repeat of succinyl-transferase COX3 PF00510.13 KII74499.1 - 0.026 13.9 0.2 0.032 13.6 0.1 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit III Urm1 PF09138.6 KII74499.1 - 0.09 12.8 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) Hid1 PF12722.2 KII74500.1 - 3.9e-06 24.9 0.2 4.7e-06 24.6 0.1 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 KII74500.1 - 0.053 11.6 0.2 0.058 11.5 0.1 1.0 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein HIN PF02760.10 KII74501.1 - 0.001 18.4 1.6 0.0011 18.3 1.1 1.0 1 0 0 1 1 1 1 HIN-200/IF120x domain HN PF00423.14 KII74501.1 - 0.029 12.6 0.3 0.039 12.2 0.2 1.2 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase HTH_28 PF13518.1 KII74502.1 - 0.00036 20.4 0.0 0.00053 19.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII74502.1 - 0.00038 20.0 0.0 0.00048 19.7 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.1 KII74502.1 - 0.015 15.4 0.0 0.041 14.0 0.0 1.6 1 1 1 2 2 2 0 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.1 KII74502.1 - 0.019 14.1 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 CENP-B_N PF04218.8 KII74502.1 - 0.021 14.2 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.1 KII74502.1 - 0.092 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Bot1p PF12298.3 KII74502.1 - 0.13 12.2 0.1 0.16 11.9 0.1 1.3 1 1 0 1 1 1 0 Eukaryotic mitochondrial regulator protein Annexin PF00191.15 KII74505.1 - 4.3e-05 23.3 4.6 0.1 12.5 0.8 2.3 2 0 0 2 2 2 2 Annexin zf-UBR PF02207.15 KII74506.1 - 1.2e-10 40.9 17.9 1.2e-10 40.9 12.4 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Serpin PF00079.15 KII74510.1 - 7.7e-28 97.6 0.6 5.9e-24 84.8 0.2 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) CDC45 PF02724.9 KII74510.1 - 0.13 10.2 8.2 0.22 9.5 5.7 1.3 1 0 0 1 1 1 0 CDC45-like protein DDE_Tnp_IS1595 PF12762.2 KII74513.1 - 1.7e-24 86.3 0.0 2.5e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_ribbon_recom PF13408.1 KII74513.1 - 0.0032 17.7 6.7 0.0086 16.3 4.6 1.7 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain DDE_Tnp_IS66 PF03050.9 KII74513.1 - 0.047 12.9 0.0 0.094 11.9 0.0 1.6 1 1 1 2 2 2 0 Transposase IS66 family Zn_Tnp_IS1595 PF12760.2 KII74513.1 - 0.06 13.1 0.5 0.06 13.1 0.3 2.0 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DDE_1 PF03184.14 KII74514.1 - 1.2e-05 24.5 0.0 1.2e-05 24.5 0.0 1.2 1 1 0 1 1 1 1 DDE superfamily endonuclease RVP PF00077.15 KII74515.1 - 1.1e-05 25.3 0.0 2.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII74515.1 - 0.072 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-UBR PF02207.15 KII74517.1 - 4.6e-14 51.8 15.0 4.6e-14 51.8 10.4 1.9 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Pkinase PF00069.20 KII74521.1 - 3.3e-38 131.3 0.1 5.8e-38 130.5 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII74521.1 - 3.5e-13 49.2 0.0 6.1e-13 48.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.6 KII74521.1 - 2e-05 23.5 0.2 3.3e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.1 KII74521.1 - 0.00071 18.6 0.0 0.0015 17.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 KII74521.1 - 0.012 15.3 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-UBR PF02207.15 KII74522.1 - 1.1e-12 47.4 22.8 2.1e-12 46.5 15.8 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Axin_b-cat_bind PF08833.5 KII74522.1 - 0.0089 15.7 0.2 0.022 14.4 0.1 1.7 1 0 0 1 1 1 1 Axin beta-catenin binding domain Herpes_UL92 PF03048.9 KII74522.1 - 0.12 11.9 13.0 0.17 11.4 9.0 1.2 1 0 0 1 1 1 0 UL92 family PolC_DP2 PF03833.8 KII74522.1 - 8 3.9 8.6 9.6 3.7 5.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 PurA PF04845.8 KII74523.1 - 0.00018 20.7 0.1 0.00025 20.2 0.0 1.2 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein FKBP_N PF01346.13 KII74524.1 - 6.8e-07 29.3 1.1 1.2e-06 28.6 0.8 1.4 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase UCH PF00443.24 KII74524.1 - 0.031 13.4 0.1 0.04 13.0 0.1 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Phage_GP20 PF06810.6 KII74524.1 - 0.14 11.6 8.0 0.57 9.6 0.1 2.3 2 0 0 2 2 2 0 Phage minor structural protein GP20 GerE PF00196.14 KII74525.1 - 1.7e-11 43.2 0.1 1.5e-09 37.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory proteins, luxR family FaeA PF04703.7 KII74525.1 - 7.6e-05 22.7 0.1 0.0002 21.4 0.0 1.7 2 0 0 2 2 2 1 FaeA-like protein Sigma70_r4_2 PF08281.7 KII74525.1 - 0.0018 17.6 0.5 1.3 8.5 0.1 3.0 3 0 0 3 3 3 2 Sigma-70, region 4 DDE_Tnp_IS1595 PF12762.2 KII74526.1 - 4.4e-07 29.8 0.0 1.3e-06 28.2 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF912 PF06024.7 KII74528.1 - 0.0051 16.8 0.1 0.0086 16.1 0.1 1.4 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Rifin_STEVOR PF02009.11 KII74528.1 - 0.0092 15.6 0.1 0.0092 15.6 0.1 1.1 1 0 0 1 1 1 1 Rifin/stevor family TMEM154 PF15102.1 KII74528.1 - 0.011 15.4 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF4448 PF14610.1 KII74528.1 - 0.012 15.1 0.1 0.017 14.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Vma12 PF11712.3 KII74528.1 - 0.022 14.4 0.1 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase EphA2_TM PF14575.1 KII74528.1 - 0.023 15.1 1.1 0.82 10.1 0.1 2.5 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain EVI2A PF05399.6 KII74528.1 - 0.025 13.8 0.1 0.041 13.1 0.1 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Baculo_11_kDa PF06143.6 KII74528.1 - 0.04 13.2 0.5 0.04 13.2 0.3 1.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family PRT_C PF08372.5 KII74528.1 - 0.087 12.3 0.1 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal DUF2207 PF09972.4 KII74528.1 - 0.094 11.2 0.0 0.16 10.4 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ETRAMP PF09716.5 KII74528.1 - 0.13 12.2 1.7 0.66 9.9 1.2 2.0 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3753 PF12575.3 KII74528.1 - 2.6 7.9 8.4 0.089 12.6 1.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) EFG_II PF14492.1 KII74531.1 - 1.9e-07 30.8 0.1 4.5e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 KII74531.1 - 2.5e-06 27.5 0.0 4.5e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_C PF00679.19 KII74531.1 - 1.5e-05 24.7 0.0 3.7e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.13 KII74531.1 - 0.0033 16.9 0.0 0.0061 16.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU PF00009.22 KII74532.1 - 8.2e-36 123.1 0.0 9.4e-36 123.0 0.0 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF2126 PF09899.4 KII74532.1 - 0.074 11.0 0.0 0.092 10.7 0.0 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Ins_P5_2-kin PF06090.7 KII74533.1 - 3.4e-35 121.6 1.8 4.3e-35 121.2 1.2 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Pkinase PF00069.20 KII74534.1 - 0.0027 16.9 0.1 0.0047 16.0 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII74534.1 - 0.0036 16.4 0.2 0.016 14.3 0.0 2.0 2 2 0 2 2 2 1 Protein tyrosine kinase Activin_recp PF01064.18 KII74535.1 - 1.5e-05 25.5 2.0 2.1e-05 25.0 1.4 1.2 1 0 0 1 1 1 1 Activin types I and II receptor domain FAT PF02259.18 KII74537.1 - 8.3e-66 222.3 0.9 8.3e-66 222.3 0.6 1.9 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.22 KII74537.1 - 9.9e-47 159.3 0.3 2.7e-46 157.9 0.2 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 KII74537.1 - 1.6e-22 79.4 3.2 6e-22 77.6 0.5 3.2 2 0 0 2 2 2 1 Rapamycin binding domain DUF3385 PF11865.3 KII74537.1 - 6e-22 78.2 2.7 6.4e-21 74.9 0.2 3.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3385) FATC PF02260.15 KII74537.1 - 7.9e-14 50.8 0.3 3.2e-13 48.8 0.2 2.2 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.1 KII74537.1 - 2.1e-08 34.3 0.1 0.062 13.5 0.0 4.6 4 0 0 4 4 4 3 HEAT repeats TPR_19 PF14559.1 KII74537.1 - 0.17 12.2 0.5 1.5e+02 2.8 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat HEAT_EZ PF13513.1 KII74537.1 - 7 7.2 4.9 1e+02 3.5 0.0 5.1 6 0 0 6 6 6 0 HEAT-like repeat Helicase_C PF00271.26 KII74538.1 - 8.4e-19 67.2 0.0 3.2e-16 58.9 0.0 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.24 KII74538.1 - 9.5e-17 60.9 0.0 5.1e-16 58.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase FAD_binding_7 PF03441.9 KII74539.1 - 0.0099 15.1 0.0 0.011 15.0 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DDE_Tnp_IS1595 PF12762.2 KII74541.1 - 3e-09 36.9 0.0 5.5e-09 36.0 0.0 1.4 1 1 1 2 2 2 1 ISXO2-like transposase domain PTS_EIIB PF00367.15 KII74541.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 phosphotransferase system, EIIB DDE_Tnp_IS1595 PF12762.2 KII74542.1 - 1.5e-12 47.5 0.4 1.7e-11 44.1 0.0 2.0 1 1 1 2 2 2 1 ISXO2-like transposase domain GDI PF00996.13 KII74543.1 - 5.9e-164 545.5 0.2 7e-164 545.3 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor TBCC PF07986.7 KII74544.1 - 4.1e-13 48.7 2.0 4.5e-13 48.6 0.6 1.7 2 0 0 2 2 2 1 Tubulin binding cofactor C YniB PF14002.1 KII74544.1 - 0.026 13.9 0.1 0.046 13.1 0.1 1.4 1 0 0 1 1 1 0 YniB-like protein EzrA PF06160.7 KII74545.1 - 0.0024 16.1 0.4 0.0029 15.8 0.2 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA AIP3 PF03915.8 KII74545.1 - 0.012 14.5 1.5 0.016 14.1 1.1 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 Apolipoprotein PF01442.13 KII74545.1 - 0.034 13.6 0.0 0.14 11.6 0.0 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF3066 PF11266.3 KII74545.1 - 0.041 13.5 0.2 0.05 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3066) DUF3461 PF11944.3 KII74545.1 - 0.053 13.3 1.6 0.11 12.3 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3461) Bacillus_HBL PF05791.6 KII74545.1 - 0.1 11.9 1.0 0.98 8.7 0.1 2.1 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DASH_Dad3 PF08656.5 KII74545.1 - 0.12 12.0 1.5 0.87 9.3 1.0 2.0 1 1 0 1 1 1 0 DASH complex subunit Dad3 DUF816 PF05674.7 KII74545.1 - 0.14 11.9 1.6 5.3 6.7 0.0 2.2 1 1 0 2 2 2 0 Baculovirus protein of unknown function (DUF816) TMF_DNA_bd PF12329.3 KII74546.1 - 0.29 10.9 4.6 0.4 10.5 0.4 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SP_C-Propep PF08999.5 KII74547.1 - 0.04 13.3 0.2 0.054 12.9 0.2 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide DUF977 PF06163.6 KII74547.1 - 0.1 12.3 0.0 0.12 12.1 0.0 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) PsbJ PF01788.12 KII74547.1 - 2.8 7.5 7.5 4.6 6.8 5.2 1.3 1 0 0 1 1 1 0 PsbJ rve PF00665.21 KII74549.1 - 1.1e-12 48.0 0.0 1.3e-12 47.8 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain RNA_pol_Rpb1_5 PF04998.12 KII74549.1 - 0.11 11.7 0.0 0.12 11.6 0.0 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Tcp10_C PF07202.8 KII74550.1 - 0.0085 15.6 0.6 0.01 15.4 0.4 1.3 1 0 0 1 1 1 1 T-complex protein 10 C-terminus SelR PF01641.13 KII74550.1 - 0.085 12.5 1.4 0.14 11.8 0.2 1.8 2 1 0 2 2 2 0 SelR domain TMF_DNA_bd PF12329.3 KII74553.1 - 6.5e-05 22.6 39.8 0.00052 19.7 3.9 4.4 3 1 1 4 4 4 2 TATA element modulatory factor 1 DNA binding Spc7 PF08317.6 KII74553.1 - 0.00096 17.9 21.1 0.00096 17.9 14.6 2.2 1 1 0 2 2 2 1 Spc7 kinetochore protein Filament PF00038.16 KII74553.1 - 0.0019 17.6 8.5 0.0019 17.6 5.9 3.5 1 1 3 4 4 4 3 Intermediate filament protein WEMBL PF05701.6 KII74553.1 - 0.0048 15.4 35.6 0.02 13.4 17.0 2.0 1 1 1 2 2 2 2 Weak chloroplast movement under blue light Med9 PF07544.8 KII74553.1 - 0.011 15.4 3.6 0.011 15.4 2.5 3.9 4 2 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Fib_alpha PF08702.5 KII74553.1 - 0.015 15.4 8.2 0.015 15.4 5.7 3.1 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.7 KII74553.1 - 0.054 13.7 12.0 0.89 9.8 2.3 3.8 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 KII74553.1 - 0.062 13.1 22.5 0.63 9.8 1.4 3.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.7 KII74553.1 - 0.083 12.0 0.2 0.083 12.0 0.1 2.4 2 1 1 3 3 3 0 Reovirus sigma C capsid protein HalX PF08663.5 KII74553.1 - 0.092 12.7 4.1 16 5.5 0.2 3.8 3 0 0 3 3 3 0 HalX domain Cullin_binding PF03556.10 KII74553.1 - 0.12 12.5 2.6 0.22 11.6 0.6 2.4 1 1 1 2 2 2 0 Cullin binding Phage_GP20 PF06810.6 KII74553.1 - 0.21 11.0 41.8 0.039 13.4 10.6 4.1 1 1 2 3 3 3 0 Phage minor structural protein GP20 APG6 PF04111.7 KII74553.1 - 0.26 10.3 41.8 0.15 11.0 3.4 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 CENP-Q PF13094.1 KII74553.1 - 0.29 11.1 36.7 0.8 9.7 8.0 3.3 1 1 2 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF869 PF05911.6 KII74553.1 - 0.31 9.2 34.7 0.91 7.6 24.1 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF869) Bap31 PF05529.7 KII74553.1 - 0.51 9.7 24.5 0.86 9.0 2.5 3.6 3 1 0 3 3 3 0 B-cell receptor-associated protein 31-like DUF3450 PF11932.3 KII74553.1 - 0.59 9.3 24.7 0.67 9.1 1.5 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) SlyX PF04102.7 KII74553.1 - 0.64 10.4 22.2 0.45 10.9 0.6 5.1 2 2 5 7 7 7 0 SlyX ATG16 PF08614.6 KII74553.1 - 0.86 9.3 43.0 3.6 7.3 11.0 3.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF1319 PF07028.6 KII74553.1 - 0.97 9.6 30.8 0.2 11.8 3.7 3.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1319) CDC37_N PF03234.9 KII74553.1 - 2.6 8.3 28.5 1.8 8.8 8.1 2.4 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Atg14 PF10186.4 KII74553.1 - 4 6.3 39.0 1.8 7.4 8.6 3.1 1 1 2 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 Fez1 PF06818.10 KII74553.1 - 4.6 7.2 27.0 6.5 6.7 8.6 2.4 1 1 1 2 2 2 0 Fez1 DUF4055 PF13264.1 KII74553.1 - 5 7.2 10.1 1.5 8.8 0.3 3.3 1 1 1 3 3 3 0 Domain of unknown function (DUF4055) COMP PF11598.3 KII74553.1 - 5.9 7.0 6.6 12 6.0 0.8 3.1 3 0 0 3 3 2 0 Cartilage oligomeric matrix protein DUF948 PF06103.6 KII74553.1 - 6.1 6.7 15.3 10 6.0 1.3 4.1 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Sialidase_penC PF12135.3 KII74553.1 - 6.8 6.4 7.3 5.5 6.7 0.2 3.1 3 0 0 3 3 3 0 Sialidase enzyme penultimate C terminal domain IncA PF04156.9 KII74553.1 - 7.3 6.1 40.7 1.2 8.7 9.2 3.2 1 1 2 3 3 3 0 IncA protein FHA PF00498.21 KII74556.1 - 3.1e-09 36.8 0.0 5.9e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 FHA domain DDE_Tnp_IS1595 PF12762.2 KII74557.1 - 3.8e-06 26.8 0.0 9.1e-06 25.5 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF791 PF05631.9 KII74558.1 - 7.6e-17 61.0 11.4 3.9e-14 52.1 1.1 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF791) Ras PF00071.17 KII74559.1 - 3.9e-15 55.5 0.0 5.6e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Ras family DUF4082 PF13313.1 KII74559.1 - 0.031 13.7 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) DUF1497 PF07384.6 KII74559.1 - 0.24 11.5 1.3 0.51 10.5 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1497) DDE_3 PF13358.1 KII74561.1 - 3.8e-19 68.8 0.0 4.3e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII74561.1 - 0.0011 18.0 0.1 0.014 14.5 0.0 2.0 1 1 1 2 2 2 1 DDE superfamily endonuclease Fe_hyd_lg_C PF02906.9 KII74562.1 - 2e-57 194.6 0.0 2.9e-57 194.0 0.0 1.3 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Rer1 PF03248.8 KII74563.1 - 9.2e-61 204.4 12.3 1.1e-60 204.2 8.5 1.0 1 0 0 1 1 1 1 Rer1 family Tic20 PF09685.5 KII74563.1 - 2.9 7.8 7.9 0.32 10.9 0.5 2.1 2 0 0 2 2 2 0 Tic20-like protein ASC PF00858.19 KII74565.1 - 0.025 13.2 0.9 0.026 13.1 0.6 1.0 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel RTP PF02334.11 KII74566.1 - 0.015 15.2 0.4 0.018 14.9 0.3 1.1 1 0 0 1 1 1 0 Replication terminator protein Pkinase PF00069.20 KII74567.1 - 1.9e-46 158.3 0.0 2.7e-46 157.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.7 KII74567.1 - 2e-28 98.8 2.2 3.4e-28 98.0 1.5 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.12 KII74567.1 - 2e-28 99.1 0.0 3e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.1 KII74567.1 - 0.0064 15.9 0.0 0.097 12.1 0.0 2.1 2 0 0 2 2 2 1 PQQ-like domain YrbL-PhoP_reg PF10707.4 KII74567.1 - 0.0089 15.3 0.0 0.019 14.2 0.0 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL PQQ PF01011.16 KII74567.1 - 0.012 15.1 0.2 0.059 12.9 0.0 2.2 2 0 0 2 2 2 0 PQQ enzyme repeat Kdo PF06293.9 KII74567.1 - 0.023 13.7 0.1 0.041 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KII74567.1 - 0.099 12.3 2.3 0.14 11.8 0.5 1.9 2 1 0 2 2 2 0 Phosphotransferase enzyme family DDE_1 PF03184.14 KII74568.1 - 2.8e-11 42.9 0.0 7.6e-11 41.5 0.0 1.6 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 KII74568.1 - 0.052 13.3 0.2 0.085 12.6 0.2 1.4 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain HTH_28 PF13518.1 KII74569.1 - 0.0006 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain DDE_3 PF13358.1 KII74569.1 - 0.014 15.1 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease ubiquitin PF00240.18 KII74570.1 - 1.3e-05 24.5 0.5 3.7e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.3 KII74570.1 - 0.00012 21.7 0.3 0.00022 20.8 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Uteroglobin PF01099.12 KII74570.1 - 0.019 14.7 0.7 0.075 12.8 0.4 2.0 1 1 1 2 2 2 0 Uteroglobin family DUF4487 PF14868.1 KII74570.1 - 0.039 12.6 0.0 0.044 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) Asparaginase_2 PF01112.13 KII74571.1 - 2.6e-35 121.7 2.0 7e-35 120.2 1.3 1.6 1 1 0 1 1 1 1 Asparaginase Colicin_V PF02674.11 KII74572.1 - 2e-05 24.4 2.3 3.3e-05 23.7 1.6 1.3 1 0 0 1 1 1 1 Colicin V production protein Strabismus PF06638.6 KII74572.1 - 0.28 9.4 3.8 0.39 8.9 2.6 1.1 1 0 0 1 1 1 0 Strabismus protein Ndc1_Nup PF09531.5 KII74572.1 - 0.29 9.5 5.9 0.49 8.7 4.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HOOK PF05622.7 KII74574.1 - 1.1e-05 23.4 32.4 1.1e-05 23.4 22.4 6.0 1 1 3 6 6 3 1 HOOK protein BicD PF09730.4 KII74574.1 - 3e-05 22.6 30.2 3e-05 22.6 20.9 8.7 1 1 6 7 7 6 2 Microtubule-associated protein Bicaudal-D CENP-F_leu_zip PF10473.4 KII74574.1 - 4.6e-05 23.2 29.4 5.9e-05 22.9 9.5 13.8 3 3 10 13 13 12 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 KII74574.1 - 0.00046 19.8 18.6 0.00046 19.8 12.9 13.9 2 2 10 13 13 11 6 IncA protein ATG16 PF08614.6 KII74574.1 - 0.00094 19.0 14.0 0.00094 19.0 9.7 13.3 3 2 7 11 11 11 5 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.2 KII74574.1 - 0.0016 18.2 14.8 0.0016 18.2 10.3 14.7 3 2 10 14 14 13 6 Tropomyosin like TPR_MLP1_2 PF07926.7 KII74574.1 - 0.0033 17.1 20.3 0.0033 17.1 14.0 13.1 6 4 5 11 11 8 3 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.7 KII74574.1 - 0.0035 16.5 7.7 0.0035 16.5 5.4 11.2 2 2 10 13 13 13 6 Reovirus sigma C capsid protein GAS PF13851.1 KII74574.1 - 0.0038 16.4 14.4 0.0038 16.4 10.0 13.4 2 2 12 14 14 14 6 Growth-arrest specific micro-tubule binding TBPIP PF07106.8 KII74574.1 - 0.0056 16.2 9.6 0.0056 16.2 6.7 16.3 2 2 15 17 17 16 4 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ADIP PF11559.3 KII74574.1 - 0.0069 16.2 4.0 0.0069 16.2 2.8 16.5 4 3 14 18 18 16 5 Afadin- and alpha -actinin-Binding ERM PF00769.14 KII74574.1 - 0.025 14.1 0.2 0.025 14.1 0.2 11.6 1 1 5 9 9 7 0 Ezrin/radixin/moesin family Filament PF00038.16 KII74574.1 - 0.27 10.6 189.4 0.012 15.0 8.9 10.0 2 2 2 7 7 7 0 Intermediate filament protein RVT_1 PF00078.22 KII74577.1 - 1.8e-16 60.1 0.0 4.3e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII74577.1 - 6e-08 32.5 0.0 1.3e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 KII74577.1 - 8.5e-06 25.5 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII74577.1 - 6.4e-05 23.3 0.1 0.00011 22.6 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 KII74577.1 - 0.00016 21.4 2.0 0.00029 20.6 1.4 1.4 1 0 0 1 1 1 1 Zinc knuckle Peptidase_A3 PF02160.10 KII74577.1 - 0.0014 18.3 0.8 0.0025 17.4 0.5 1.4 1 0 0 1 1 1 1 Cauliflower mosaic virus peptidase (A3) Asp_protease PF09668.5 KII74577.1 - 0.022 14.3 0.0 0.046 13.2 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Y_phosphatase PF00102.22 KII74579.1 - 1.7e-68 230.4 5.6 2.2e-68 230.0 3.9 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KII74579.1 - 0.00015 21.7 0.2 0.00062 19.8 0.0 2.1 2 1 0 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.15 KII74579.1 - 0.0013 18.3 0.1 0.0068 15.9 0.0 2.2 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 KII74579.1 - 0.0013 19.0 0.0 0.0034 17.6 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family MoCF_biosynth PF00994.19 KII74580.1 - 5.8e-10 38.7 0.0 9e-10 38.1 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_C PF03454.10 KII74580.1 - 5e-06 26.3 0.0 8.4e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) AKAP_110 PF05716.8 KII74581.1 - 0.1 10.5 0.0 0.14 10.1 0.0 1.2 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) Ig_2 PF13895.1 KII74582.1 - 0.0015 18.6 0.1 0.0046 17.0 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain TMEM154 PF15102.1 KII74582.1 - 0.0024 17.6 0.0 0.004 16.8 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family ABC_membrane PF00664.18 KII74582.1 - 0.0089 15.4 0.2 0.014 14.8 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SIT PF15330.1 KII74582.1 - 0.018 15.1 0.1 0.039 14.0 0.0 1.6 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Herpes_gE PF02480.11 KII74582.1 - 0.032 12.4 0.0 0.043 12.0 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.1 KII74582.1 - 0.063 13.6 0.1 0.13 12.7 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain UPF0114 PF03350.11 KII74582.1 - 0.089 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein family, UPF0114 I-set PF07679.11 KII74582.1 - 0.091 12.6 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ly49 PF08391.5 KII74582.1 - 0.1 12.7 0.1 0.27 11.3 0.1 1.7 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region GRA6 PF05084.8 KII74582.1 - 0.13 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Granule antigen protein (GRA6) LRRC37AB_C PF14914.1 KII74582.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Mito_fiss_reg PF05308.6 KII74583.1 - 0.27 10.5 12.9 0.44 9.8 8.9 1.4 1 1 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.14 KII74583.1 - 5.1 6.2 10.7 7.6 5.7 7.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HTH_29 PF13551.1 KII74584.1 - 2.4e-08 34.1 0.0 3.5e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII74584.1 - 9e-08 31.5 0.1 8.7e-06 25.2 0.0 2.8 2 1 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KII74584.1 - 2.7e-05 24.0 0.0 0.00017 21.5 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.1 KII74584.1 - 5.7e-05 23.8 0.1 0.0002 22.1 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 KII74584.1 - 9.2e-05 22.4 0.2 0.00025 21.0 0.0 1.8 2 0 0 2 2 2 1 Transposase PAX PF00292.13 KII74584.1 - 0.0004 20.1 0.2 0.00056 19.6 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_17 PF12728.2 KII74584.1 - 0.00075 19.6 0.0 0.81 9.9 0.0 2.6 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 KII74584.1 - 0.0011 18.6 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_psq PF05225.11 KII74584.1 - 0.0027 17.2 0.0 0.25 10.9 0.0 2.3 2 0 0 2 2 2 1 helix-turn-helix, Psq domain TrmB PF01978.14 KII74584.1 - 0.0043 16.7 0.0 0.087 12.5 0.0 2.3 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_33 PF13592.1 KII74584.1 - 0.005 16.3 0.1 0.0085 15.6 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_3 PF01381.17 KII74584.1 - 0.0067 16.2 0.1 0.069 13.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix HTH_24 PF13412.1 KII74584.1 - 0.0073 15.6 0.1 1.5 8.2 0.0 2.4 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.11 KII74584.1 - 0.013 14.8 0.2 0.1 11.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_11 PF08279.7 KII74584.1 - 0.02 14.5 0.1 0.041 13.5 0.1 1.5 1 0 0 1 1 1 0 HTH domain MarR_2 PF12802.2 KII74584.1 - 0.022 14.4 0.0 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 MarR family HTH_37 PF13744.1 KII74584.1 - 0.028 14.2 0.1 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Nuc_rec_co-act PF08815.5 KII74584.1 - 0.031 13.8 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Nuclear receptor coactivator Sigma70_r4_2 PF08281.7 KII74584.1 - 0.073 12.5 0.0 4.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_38 PF13936.1 KII74584.1 - 0.074 12.6 0.2 0.33 10.5 0.0 2.1 2 1 1 3 3 3 0 Helix-turn-helix domain HTH_AsnC-type PF13404.1 KII74584.1 - 0.098 12.2 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain DUF4304 PF14137.1 KII74585.1 - 0.07 13.2 0.1 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4304) WH1 PF00568.18 KII74586.1 - 0.0072 16.0 0.5 0.019 14.6 0.1 1.8 1 1 1 2 2 2 1 WH1 domain Ebola_NP PF05505.7 KII74587.1 - 0.65 7.9 8.2 0.73 7.8 5.7 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein DDE_3 PF13358.1 KII74589.1 - 1.2e-07 31.5 0.0 2.7e-07 30.4 0.0 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF4251 PF14059.1 KII74589.1 - 0.027 14.2 0.0 0.035 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4251) DUF1335 PF07056.6 KII74589.1 - 0.059 13.1 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) PIF1 PF05970.9 KII74590.1 - 2e-07 30.3 0.1 2.7e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 PIF1-like helicase UvrD_C_2 PF13538.1 KII74590.1 - 6e-06 26.3 0.0 9.4e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.9 KII74590.1 - 0.00013 19.9 0.0 0.00017 19.5 0.0 1.1 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.13 KII74590.1 - 0.015 14.8 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF871 PF05913.6 KII74591.1 - 0.015 14.1 0.0 0.015 14.1 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF871) DDE_3 PF13358.1 KII74592.1 - 0.021 14.5 0.1 0.023 14.4 0.1 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF3557 PF12078.3 KII74592.1 - 0.055 13.1 0.3 0.079 12.6 0.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3557) Nipped-B_C PF12830.2 KII74592.1 - 0.073 12.7 0.3 0.078 12.6 0.2 1.1 1 0 0 1 1 1 0 Sister chromatid cohesion C-terminus EBP PF05241.7 KII74592.1 - 0.08 11.9 0.0 0.093 11.7 0.0 1.1 1 0 0 1 1 1 0 Emopamil binding protein FAD_binding_2 PF00890.19 KII74593.1 - 4.3e-116 388.1 1.2 5.3e-116 387.8 0.9 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 KII74593.1 - 8e-41 138.9 0.1 1.3e-40 138.2 0.0 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 KII74593.1 - 6.6e-05 22.8 0.9 0.0017 18.2 0.0 2.8 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KII74593.1 - 9.8e-05 21.5 0.0 0.019 14.0 0.0 2.4 2 0 0 2 2 2 2 Thi4 family DAO PF01266.19 KII74593.1 - 0.005 15.7 0.1 0.012 14.5 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 KII74593.1 - 0.0067 15.3 0.8 0.047 12.5 0.5 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.14 KII74593.1 - 0.14 11.2 0.1 0.24 10.4 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain ubiquitin PF00240.18 KII74593.1 - 0.15 11.4 0.0 0.32 10.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family HI0933_like PF03486.9 KII74593.1 - 0.15 10.4 0.4 0.33 9.3 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein DDE_Tnp_IS1595 PF12762.2 KII74594.1 - 4.2e-16 59.1 0.2 1.2e-15 57.6 0.1 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII74595.1 - 5.3e-32 110.5 0.0 6.7e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII74595.1 - 6.8e-05 22.9 0.0 0.0001 22.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-UBR PF02207.15 KII74596.1 - 4.8e-08 32.6 6.9 7.3e-08 32.0 4.8 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.19 KII74596.1 - 0.086 12.7 2.3 0.086 12.7 1.6 1.8 2 0 0 2 2 2 0 B-box zinc finger DUF413 PF04219.7 KII74597.1 - 0.034 13.8 0.0 0.065 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF DDE_1 PF03184.14 KII74598.1 - 6.8e-16 58.0 0.2 2.6e-07 29.9 0.1 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease STN1_2 PF09170.5 KII74599.1 - 0.0072 16.1 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Response_reg PF00072.19 KII74601.1 - 7.6e-27 93.5 0.1 1.2e-26 92.9 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.14 KII74601.1 - 3.3e-22 77.5 0.2 5.7e-22 76.7 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.7 KII74601.1 - 0.00014 21.2 0.0 0.00024 20.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.11 KII74601.1 - 0.0037 16.5 0.1 0.034 13.4 0.0 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_24 PF13412.1 KII74601.1 - 0.022 14.1 0.1 0.045 13.1 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Dot_icm_IcmQ PF09475.5 KII74601.1 - 0.058 12.6 0.1 0.089 12.0 0.1 1.3 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) KdpD PF02702.12 KII74601.1 - 0.096 11.8 0.6 0.46 9.5 0.1 2.1 1 1 1 2 2 2 0 Osmosensitive K+ channel His kinase sensor domain HTH_23 PF13384.1 KII74601.1 - 0.1 12.2 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HisKA_3 PF07730.8 KII74602.1 - 2.1e-14 53.5 0.0 4.8e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase YmzC PF14157.1 KII74602.1 - 0.053 13.3 0.1 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 YmzC-like protein SART-1 PF03343.8 KII74602.1 - 0.24 9.6 0.7 1.1 7.4 0.2 1.9 2 0 0 2 2 2 0 SART-1 family ABG_transport PF03806.8 KII74603.1 - 0.02 12.9 0.0 0.022 12.8 0.0 1.1 1 0 0 1 1 1 0 AbgT putative transporter family Imm7 PF15588.1 KII74603.1 - 0.021 14.8 0.1 0.54 10.3 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 7 CD47 PF04549.9 KII74603.1 - 0.059 13.3 2.8 0.23 11.4 1.6 1.9 1 1 1 2 2 2 0 CD47 transmembrane region PMT_2 PF13231.1 KII74604.1 - 1.5e-09 37.9 13.9 1.5e-09 37.9 9.7 3.0 1 1 2 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Peptidase_M50B PF13398.1 KII74604.1 - 3.4 7.0 30.4 6.2 6.1 6.9 3.1 1 1 2 3 3 3 0 Peptidase M50B-like Bac_transf PF02397.11 KII74605.1 - 4.3e-31 107.4 0.0 6.2e-31 106.9 0.0 1.2 1 0 0 1 1 1 1 Bacterial sugar transferase DUF1577 PF07614.6 KII74605.1 - 0.037 12.9 0.0 0.056 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) PS_pyruv_trans PF04230.8 KII74606.1 - 2.4e-27 96.3 0.5 3.3e-27 95.9 0.3 1.1 1 0 0 1 1 1 1 Polysaccharide pyruvyl transferase Glycos_transf_2 PF00535.21 KII74607.1 - 9.4e-37 126.2 0.2 1.4e-36 125.7 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KII74607.1 - 4.5e-13 49.5 0.0 2.8e-12 46.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KII74607.1 - 2.8e-09 36.4 0.1 3.8e-09 36.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 KII74607.1 - 0.0004 20.6 0.1 0.0011 19.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 RILP PF11461.3 KII74607.1 - 0.0035 17.4 0.4 3.2 7.9 0.2 2.3 2 0 0 2 2 2 2 Rab interacting lysosomal protein Glyco_trans_2_3 PF13632.1 KII74607.1 - 0.024 14.3 0.5 0.28 10.8 0.3 2.0 1 1 0 1 1 1 0 Glycosyl transferase family group 2 Telomere_Sde2 PF13019.1 KII74608.1 - 1.5e-23 83.2 0.0 2.3e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Telomere stability and silencing DUF3989 PF13150.1 KII74612.1 - 0.011 15.1 0.3 0.042 13.2 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) RhoGEF PF00621.15 KII74613.1 - 1e-12 48.3 3.6 1e-12 48.3 2.5 2.8 1 1 2 3 3 3 1 RhoGEF domain AAA PF00004.24 KII74615.1 - 3e-07 30.7 0.0 4.3e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KII74615.1 - 3.1e-06 27.3 0.0 6.4e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 KII74615.1 - 1.6e-05 24.5 0.0 2.1e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain Viral_helicase1 PF01443.13 KII74615.1 - 0.00014 21.4 0.0 0.00017 21.1 0.0 1.1 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Rad17 PF03215.10 KII74615.1 - 0.00014 20.6 0.0 0.00017 20.4 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 KII74615.1 - 0.00015 20.8 0.0 0.00019 20.5 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 KII74615.1 - 0.00029 20.7 0.0 0.00046 20.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KII74615.1 - 0.00031 20.8 0.4 0.016 15.3 0.1 2.1 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.8 KII74615.1 - 0.00057 18.8 0.0 0.0007 18.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 KII74615.1 - 0.0011 18.7 0.0 0.0022 17.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 KII74615.1 - 0.0018 18.5 0.0 0.0026 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KII74615.1 - 0.0024 17.3 0.1 0.13 11.7 0.1 2.1 1 1 1 2 2 2 1 AAA-like domain ArgK PF03308.11 KII74615.1 - 0.0036 16.1 0.0 0.017 13.8 0.0 1.7 1 1 1 2 2 2 1 ArgK protein Mg_chelatase PF01078.16 KII74615.1 - 0.0047 16.1 0.0 0.0054 15.9 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KII74615.1 - 0.0053 16.1 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 KII74615.1 - 0.0066 16.0 0.0 0.0084 15.7 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 KII74615.1 - 0.0066 15.9 0.0 0.0084 15.5 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family DNA_pol3_delta2 PF13177.1 KII74615.1 - 0.012 15.2 0.0 0.13 11.9 0.0 1.9 1 1 1 2 2 2 0 DNA polymerase III, delta subunit AAA_28 PF13521.1 KII74615.1 - 0.013 15.4 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 KII74615.1 - 0.014 15.0 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3885 PF13021.1 KII74615.1 - 0.019 14.6 0.1 0.043 13.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) SRP54 PF00448.17 KII74615.1 - 0.044 13.2 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.17 KII74615.1 - 0.049 13.8 0.0 0.07 13.3 0.0 1.3 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.10 KII74615.1 - 0.06 13.0 0.2 0.12 12.1 0.1 1.6 1 1 0 1 1 1 0 NTPase cobW PF02492.14 KII74615.1 - 0.061 12.7 0.1 0.093 12.1 0.1 1.4 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.4 KII74615.1 - 0.062 11.9 0.0 0.077 11.6 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_29 PF13555.1 KII74615.1 - 0.066 12.7 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SE PF00437.15 KII74615.1 - 0.082 11.7 0.0 0.091 11.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.4 KII74615.1 - 0.11 11.4 0.3 0.52 9.2 0.2 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.1 KII74615.1 - 0.12 13.2 0.8 0.21 12.4 0.5 1.6 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.1 KII74615.1 - 0.13 11.8 0.1 0.28 10.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain Ribosomal_L18e PF00828.14 KII74618.1 - 2.7e-13 50.4 0.0 4.3e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Ribosomal_L19e PF01280.15 KII74618.1 - 0.6 9.8 4.5 1 9.1 3.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L19e Acetyltransf_1 PF00583.19 KII74619.1 - 8.6e-15 54.5 0.0 1.2e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KII74619.1 - 2.1e-06 27.7 0.1 3.6e-06 27.0 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KII74619.1 - 2.5e-06 27.5 0.0 3.8e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KII74619.1 - 0.00059 19.6 0.0 0.037 13.8 0.1 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.1 KII74619.1 - 0.058 13.3 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KII74619.1 - 0.062 13.2 0.1 0.12 12.2 0.0 1.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 KII74619.1 - 0.069 12.9 0.0 0.34 10.6 0.0 1.9 1 1 1 2 2 2 0 FR47-like protein Amidase_2 PF01510.20 KII74620.1 - 0.091 12.8 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase ATP-synt_ab PF00006.20 KII74621.1 - 1e-70 237.6 0.0 2e-70 236.6 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KII74621.1 - 9.8e-25 87.2 0.6 3.4e-24 85.5 0.1 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KII74621.1 - 2.7e-17 62.7 1.7 6.2e-17 61.5 1.2 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 KII74621.1 - 0.00043 20.1 2.0 0.026 14.4 0.1 2.4 1 1 1 2 2 2 2 HAS barrel domain BPL_LplA_LipB PF03099.14 KII74623.1 - 3.1e-14 53.0 0.0 5.7e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Ribosomal_L27e PF01777.13 KII74624.1 - 2.1e-25 88.6 11.5 2.7e-25 88.2 7.5 1.5 2 0 0 2 2 2 1 Ribosomal L27e protein family KOW PF00467.24 KII74624.1 - 3.5e-05 23.3 0.1 9.9e-05 21.9 0.1 1.8 1 1 0 1 1 1 1 KOW motif G10 PF01125.12 KII74624.1 - 0.14 11.7 0.1 0.16 11.4 0.1 1.1 1 0 0 1 1 1 0 G10 protein GMP_synt_C PF00958.17 KII74625.1 - 2.2e-17 62.5 0.1 2.7e-15 55.8 0.1 3.1 1 1 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.23 KII74625.1 - 1.2e-16 60.7 0.0 2e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 KII74625.1 - 5.2e-06 25.5 0.0 0.0093 14.8 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 KII74625.1 - 0.00011 21.7 0.0 0.00023 20.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 QueC PF06508.8 KII74625.1 - 0.0006 19.1 0.0 0.001 18.3 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 KII74625.1 - 0.0009 18.8 0.0 0.0026 17.2 0.0 1.8 2 0 0 2 2 2 1 Asparagine synthase tRNA_Me_trans PF03054.11 KII74625.1 - 0.0092 14.5 0.1 0.15 10.5 0.0 2.4 3 0 0 3 3 3 1 tRNA methyl transferase ThiI PF02568.9 KII74625.1 - 0.01 15.3 0.0 0.038 13.4 0.0 2.0 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) DUF4147 PF13660.1 KII74625.1 - 0.16 11.0 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) DnaJ PF00226.26 KII74628.1 - 0.037 13.7 0.1 2.3 8.0 0.0 2.8 3 0 0 3 3 3 0 DnaJ domain cNMP_binding PF00027.24 KII74629.1 - 1e-23 82.9 0.0 1.3e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Pox_I1 PF03289.8 KII74629.1 - 0.054 12.3 1.6 0.062 12.1 1.1 1.2 1 0 0 1 1 1 0 Poxvirus protein I1 RRM_1 PF00076.17 KII74630.1 - 1.3e-07 31.1 0.0 3.9e-07 29.5 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KII74630.1 - 2.7e-06 27.2 0.0 1.2e-05 25.1 0.0 2.1 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KII74630.1 - 0.00074 19.3 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHD PF00628.24 KII74631.1 - 0.033 13.8 9.4 0.063 12.9 6.5 1.5 1 0 0 1 1 1 0 PHD-finger DUF4371 PF14291.1 KII74632.1 - 2.6e-12 46.7 0.4 8.6e-12 45.0 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4371) Med9 PF07544.8 KII74632.1 - 0.81 9.4 4.5 1 9.1 0.0 2.9 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF1664 PF07889.7 KII74632.1 - 0.82 9.4 3.9 61 3.4 0.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) TFIID-18kDa PF02269.11 KII74633.1 - 3.2e-19 68.5 0.3 4.3e-19 68.1 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit PI3K_p85B PF02192.11 KII74634.1 - 0.23 10.9 1.7 0.57 9.6 0.1 2.1 1 1 1 2 2 2 0 PI3-kinase family, p85-binding domain Arrestin_C PF02752.17 KII74634.1 - 0.62 10.1 3.9 0.87 9.6 2.7 1.5 1 1 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain BTB_2 PF02214.17 KII74636.1 - 8e-12 45.2 0.0 5.7e-11 42.4 0.0 2.2 1 1 0 1 1 1 1 BTB/POZ domain YejG PF13989.1 KII74636.1 - 0.12 12.4 0.1 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 YejG-like protein HORMA PF02301.13 KII74637.1 - 1.6e-32 112.7 3.3 1.8e-32 112.5 2.3 1.0 1 0 0 1 1 1 1 HORMA domain PLA2_B PF01735.13 KII74637.1 - 0.12 10.5 0.4 0.14 10.3 0.3 1.0 1 0 0 1 1 1 0 Lysophospholipase catalytic domain DnaJ PF00226.26 KII74638.1 - 0.0013 18.3 0.0 0.072 12.8 0.0 2.2 2 0 0 2 2 2 2 DnaJ domain ARL2_Bind_BART PF11527.3 KII74638.1 - 1.4 8.7 4.9 35 4.2 0.1 3.0 2 1 1 3 3 3 0 The ARF-like 2 binding protein BART DER1 PF04511.10 KII74639.1 - 8.6e-49 165.7 18.0 9.9e-49 165.5 12.5 1.0 1 0 0 1 1 1 1 Der1-like family AMP-binding PF00501.23 KII74640.1 - 2.8e-73 246.6 0.0 3.7e-73 246.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PseudoU_synth_2 PF00849.17 KII74641.1 - 6.7e-08 32.5 0.0 9.9e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase AA_permease_2 PF13520.1 KII74643.1 - 1.9e-40 138.6 31.5 2.2e-40 138.5 21.8 1.0 1 0 0 1 1 1 1 Amino acid permease SH2 PF00017.19 KII74644.1 - 2.1e-15 56.2 0.5 4.6e-15 55.1 0.4 1.6 1 0 0 1 1 1 1 SH2 domain C1_1 PF00130.17 KII74644.1 - 3.3e-08 33.1 6.1 8.9e-08 31.7 4.2 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RhoGEF PF00621.15 KII74645.1 - 4.1e-14 52.8 7.1 4.1e-14 52.8 4.9 2.3 1 1 1 2 2 2 1 RhoGEF domain CDC24 PF06395.6 KII74645.1 - 6.5e-09 35.7 3.5 1.5e-08 34.5 0.1 2.8 3 0 0 3 3 3 1 CDC24 Calponin CH PF00307.26 KII74645.1 - 5.7e-08 32.7 2.3 1.7e-06 27.9 0.3 2.6 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KII74645.1 - 0.042 13.5 1.7 0.13 11.8 0.1 2.5 2 0 0 2 2 2 0 CAMSAP CH domain L51_S25_CI-B8 PF05047.11 KII74646.1 - 0.0017 18.0 0.4 0.0056 16.3 0.2 1.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain rve PF00665.21 KII74647.1 - 1.9e-28 98.9 0.0 3.7e-28 98.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74647.1 - 0.0012 18.3 0.0 0.0027 17.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII74647.1 - 0.0073 16.2 0.4 0.058 13.3 0.0 2.1 2 0 0 2 2 2 1 DDE domain PCI PF01399.22 KII74648.1 - 0.035 14.4 0.2 0.048 13.9 0.1 1.3 1 0 0 1 1 1 0 PCI domain FANCI_S2 PF14676.1 KII74649.1 - 0.067 13.0 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 FANCI solenoid 2 ACDC PF14733.1 KII74649.1 - 0.08 13.0 1.5 0.18 11.9 0.1 2.3 2 2 0 2 2 2 0 AP2-coincident C-terminal FluMu_gp41 PF10109.4 KII74650.1 - 0.0047 16.8 3.3 2 8.3 0.1 3.3 2 1 1 3 3 3 2 Mu-like prophage FluMu protein gp41 Amidohydro_2 PF04909.9 KII74650.1 - 0.011 15.3 0.7 0.021 14.3 0.5 1.5 1 1 0 1 1 1 0 Amidohydrolase DDE_Tnp_IS1595 PF12762.2 KII74651.1 - 3.6e-16 59.3 0.1 3.9e-16 59.2 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.1 KII74654.1 - 1.1e-12 47.8 0.2 1.2e-12 47.8 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII74654.1 - 0.037 14.1 0.0 0.046 13.8 0.0 1.1 1 0 0 1 1 1 0 Integrase core domain Lipoprotein_8 PF02030.10 KII74656.1 - 0.043 12.3 0.1 0.051 12.0 0.0 1.0 1 0 0 1 1 1 0 Hypothetical lipoprotein (MG045 family) Gmad1 PF10647.4 KII74656.1 - 0.07 12.5 0.0 0.093 12.1 0.0 1.1 1 0 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain Serpin PF00079.15 KII74657.1 - 5.8e-35 121.1 5.9 6.5e-35 120.9 4.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Peptidase_S24 PF00717.18 KII74658.1 - 1.5e-10 40.5 1.8 5.3e-10 38.7 0.4 2.1 1 1 2 3 3 3 1 Peptidase S24-like Peptidase_S26 PF10502.4 KII74658.1 - 0.0021 17.5 0.1 0.009 15.5 0.1 1.9 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 DUF4438 PF14505.1 KII74658.1 - 0.049 12.3 0.1 0.072 11.8 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4438) GTP_EFTU_D2 PF03144.20 KII74658.1 - 0.16 12.1 0.5 2.9 8.0 0.0 2.3 1 1 1 2 2 2 0 Elongation factor Tu domain 2 DUF2463 PF09591.5 KII74659.1 - 0.023 14.2 1.0 0.033 13.7 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) SHP PF03579.8 KII74659.1 - 0.061 12.6 0.5 0.15 11.4 0.2 1.7 1 1 1 2 2 2 0 Small hydrophobic protein DUF382 PF04037.8 KII74660.1 - 0.034 13.9 2.0 0.047 13.5 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF382) DUF3958 PF13125.1 KII74660.1 - 0.31 10.9 4.9 0.43 10.4 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) DDE_3 PF13358.1 KII74661.1 - 1.2e-25 89.9 0.0 2e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII74661.1 - 0.00037 20.4 1.3 0.0021 18.0 0.0 2.8 4 0 0 4 4 4 1 Transposase HTH_29 PF13551.1 KII74661.1 - 0.0022 18.0 0.0 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 KII74661.1 - 0.013 16.2 0.1 0.033 14.9 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain HTH_21 PF13276.1 KII74661.1 - 0.016 15.2 0.0 4.4 7.3 0.0 2.5 2 0 0 2 2 2 0 HTH-like domain DDE_Tnp_ISAZ013 PF07592.6 KII74661.1 - 0.019 13.7 0.6 3.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain HTH_23 PF13384.1 KII74661.1 - 0.15 11.7 0.1 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain IU_nuc_hydro PF01156.14 KII74662.1 - 1.9e-44 152.1 0.1 2.2e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase ParB PF08775.5 KII74664.1 - 0.03 14.6 1.5 0.03 14.6 1.0 2.3 1 1 1 2 2 2 0 ParB family PTPS PF01242.14 KII74664.1 - 0.12 12.0 2.0 0.18 11.4 0.5 2.0 1 1 1 2 2 2 0 6-pyruvoyl tetrahydropterin synthase Kinase-PPPase PF03618.9 KII74664.1 - 0.27 10.6 5.3 0.074 12.5 0.9 1.8 1 1 1 2 2 2 0 Kinase/pyrophosphorylase Lzipper-MIP1 PF14389.1 KII74664.1 - 0.51 10.4 5.5 1.1 9.4 0.6 2.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 BNR PF02012.15 KII74668.1 - 4.3e-05 22.7 0.5 0.26 11.2 0.0 3.3 3 0 0 3 3 3 2 BNR/Asp-box repeat SNAP PF14938.1 KII74671.1 - 0.005 16.0 8.3 0.68 9.0 0.1 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII74671.1 - 0.038 13.9 1.9 5 7.1 0.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat NUP50 PF08911.6 KII74672.1 - 0.011 16.1 0.0 0.12 12.7 0.0 2.1 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) eIF_4G1 PF12152.3 KII74677.1 - 0.2 11.5 0.9 0.34 10.8 0.3 1.6 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 4G1 EGF_2 PF07974.8 KII74678.1 - 0.013 15.6 2.1 0.013 15.6 1.5 1.9 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.2 KII74678.1 - 0.013 15.4 2.2 0.028 14.4 1.5 1.6 1 0 0 1 1 1 0 Human growth factor-like EGF MOR2-PAG1_N PF14222.1 KII74680.1 - 7.9e-20 71.0 7.8 9.7e-20 70.7 5.4 1.0 1 0 0 1 1 1 1 Cell morphogenesis N-terminal DUF1827 PF08860.5 KII74680.1 - 0.055 13.5 0.4 0.089 12.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1827) DDE_3 PF13358.1 KII74681.1 - 0.0098 15.6 0.0 0.01 15.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease FGGY_N PF00370.16 KII74682.1 - 0.096 11.9 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Tetraspannin PF00335.15 KII74686.1 - 0.00039 19.7 3.9 0.00046 19.5 2.7 1.1 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.10 KII74686.1 - 0.0026 17.6 0.5 0.0031 17.4 0.3 1.2 1 0 0 1 1 1 1 CD20-like family rve PF00665.21 KII74689.1 - 1.2e-29 102.9 0.0 3.5e-29 101.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII74689.1 - 1.1e-25 90.2 0.1 2.5e-25 89.1 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII74689.1 - 8.8e-06 25.5 0.1 2.4e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 KII74689.1 - 1.2e-05 24.8 0.0 4.2e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.18 KII74689.1 - 7.9e-05 22.3 10.1 0.016 15.0 1.6 2.8 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII74689.1 - 0.001 19.5 0.0 0.0026 18.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII74689.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.1 KII74689.1 - 0.0019 17.6 0.0 0.0068 15.9 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.6 KII74689.1 - 0.0025 17.7 0.4 0.0061 16.5 0.3 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII74689.1 - 0.014 15.0 1.4 0.014 15.0 1.0 2.8 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.1 KII74689.1 - 0.4 10.3 14.1 0.12 12.0 1.9 2.6 2 0 0 2 2 2 0 Zinc knuckle SNAP PF14938.1 KII74690.1 - 7.1e-07 28.6 0.6 1.1e-06 28.0 0.3 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP SBP56 PF05694.6 KII74692.1 - 0.12 10.8 0.0 0.13 10.7 0.0 1.0 1 0 0 1 1 1 0 56kDa selenium binding protein (SBP56) DUF243 PF03103.12 KII74692.1 - 0.14 12.2 1.0 0.2 11.7 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF243) DDE_3 PF13358.1 KII74693.1 - 9.8e-32 109.7 0.0 1.2e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 KII74693.1 - 5e-06 25.8 0.0 1e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII74693.1 - 6.7e-05 22.9 0.0 9.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF573 PF04504.9 KII74694.1 - 0.5 10.6 4.0 8.1 6.7 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function, DUF573 DDE_3 PF13358.1 KII74695.1 - 1e-35 122.6 0.0 1.6e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 KII74695.1 - 9.8e-07 28.7 0.1 2.5e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 Transposase rve PF00665.21 KII74695.1 - 1.4e-05 25.1 0.0 2.4e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_32 PF13565.1 KII74695.1 - 0.0028 18.4 0.2 0.012 16.3 0.0 2.2 2 1 1 3 3 3 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 KII74695.1 - 0.0085 15.7 1.3 2.8 7.6 0.1 2.3 1 1 1 2 2 2 2 Transposase HTH_29 PF13551.1 KII74695.1 - 0.011 15.8 0.0 0.034 14.2 0.0 1.9 1 1 0 1 1 1 0 Winged helix-turn helix HTH_33 PF13592.1 KII74695.1 - 0.016 14.7 0.0 0.039 13.5 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix Tn7_Tnp_TnsA_C PF08721.6 KII74695.1 - 0.042 13.8 0.7 2 8.4 0.0 3.0 3 0 0 3 3 3 0 TnsA endonuclease C terminal DDE_1 PF03184.14 KII74695.1 - 0.045 12.8 0.1 0.31 10.1 0.0 2.2 2 1 1 3 3 3 0 DDE superfamily endonuclease HTH_28 PF13518.1 KII74695.1 - 0.087 12.8 0.1 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain PRELI PF04707.9 KII74700.1 - 0.015 14.8 0.4 0.017 14.6 0.3 1.1 1 0 0 1 1 1 0 PRELI-like family Peptidase_C1 PF00112.18 KII74703.1 - 7.6e-35 120.7 0.7 8.9e-35 120.5 0.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease GST_C PF00043.20 KII74704.1 - 0.089 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Fun_ATP-synt_8 PF05933.8 KII74704.1 - 6.2 6.9 6.5 0.28 11.2 0.4 2.0 2 0 0 2 2 2 0 Fungal ATP synthase protein 8 (A6L) PLAC PF08686.6 KII74705.1 - 0.017 15.3 4.8 2.6 8.3 0.0 3.3 3 0 0 3 3 3 0 PLAC (protease and lacunin) domain rve PF00665.21 KII74707.1 - 1.4e-06 28.4 0.0 0.0035 17.4 0.0 2.8 2 1 0 2 2 2 1 Integrase core domain MFS_1 PF07690.11 KII74708.1 - 7.2e-28 97.3 22.2 3.1e-26 91.9 13.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Herpes_LMP1 PF05297.6 KII74708.1 - 0.11 11.4 3.6 0.19 10.6 2.5 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) rve PF00665.21 KII74710.1 - 3.9e-20 72.1 0.1 6e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74710.1 - 4e-05 23.0 0.0 8.9e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII74710.1 - 0.00016 21.4 0.0 0.00028 20.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Nepo_coat_N PF03689.10 KII74710.1 - 0.018 14.7 0.1 0.16 11.6 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain DUF1796 PF08795.5 KII74710.1 - 0.041 13.5 0.1 0.077 12.6 0.1 1.4 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Fucose_iso_N2 PF07882.7 KII74711.1 - 0.026 14.2 1.4 0.034 13.7 1.0 1.1 1 0 0 1 1 1 0 L-fucose isomerase, second N-terminal domain Nop10p PF04135.7 KII74713.1 - 0.56 9.9 2.8 3 7.6 1.9 2.2 1 1 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family Chordopox_L2 PF05803.7 KII74714.1 - 0.016 14.8 0.2 0.039 13.5 0.2 1.6 1 0 0 1 1 1 0 Chordopoxvirus L2 protein DUF4596 PF15363.1 KII74714.1 - 2.4 8.1 6.0 29 4.6 2.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4596) Methyltransf_28 PF02636.12 KII74715.1 - 4.9e-09 35.9 0.0 5.4e-09 35.8 0.0 1.0 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase UPF0253 PF06786.7 KII74715.1 - 0.0072 16.4 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0253) SET PF00856.23 KII74717.1 - 1.1e-17 64.8 0.0 6.5e-17 62.3 0.0 2.1 1 1 0 1 1 1 1 SET domain Ras PF00071.17 KII74718.1 - 9.5e-44 148.6 0.0 1.1e-43 148.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII74718.1 - 9.8e-15 55.0 0.0 1.5e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII74718.1 - 6.4e-10 38.5 0.0 7.8e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KII74718.1 - 3.2e-05 23.4 0.0 0.00074 19.0 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KII74718.1 - 4.2e-05 23.4 0.0 7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 KII74718.1 - 0.00031 20.2 0.0 0.72 9.3 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.1 KII74718.1 - 0.0023 18.7 0.0 0.0032 18.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 KII74718.1 - 0.0039 16.9 0.0 0.0057 16.3 0.0 1.2 1 0 0 1 1 1 1 NTPase G-alpha PF00503.15 KII74718.1 - 0.015 13.9 0.6 0.022 13.4 0.4 1.4 1 1 0 1 1 1 0 G-protein alpha subunit MobB PF03205.9 KII74718.1 - 0.024 14.3 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DnaB_C PF03796.10 KII74718.1 - 0.026 13.4 0.0 0.037 12.9 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Gtr1_RagA PF04670.7 KII74718.1 - 0.033 13.3 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_18 PF13238.1 KII74718.1 - 0.048 13.9 0.0 0.099 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 KII74718.1 - 0.083 12.3 0.0 0.19 11.1 0.0 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.8 KII74718.1 - 0.14 10.8 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus zf-UBR PF02207.15 KII74719.1 - 1.8e-05 24.3 1.9 2.9e-05 23.6 1.3 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) TrbH PF07283.6 KII74720.1 - 0.094 12.5 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 Conjugal transfer protein TrbH DUF1803 PF08820.5 KII74721.1 - 0.023 14.3 0.7 0.25 11.0 0.1 2.9 2 2 1 3 3 3 0 Domain of unknown function (DUF1803) Tetraspannin PF00335.15 KII74722.1 - 1.3e-13 50.7 10.6 1.6e-13 50.4 7.3 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF4418 PF14387.1 KII74722.1 - 0.08 12.6 6.0 0.042 13.6 1.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4418) FCH PF00611.18 KII74724.1 - 0.0083 16.2 0.2 0.0094 16.1 0.2 1.2 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DUF4484 PF14831.1 KII74724.1 - 0.024 14.7 0.6 0.024 14.7 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) TEX12 PF15219.1 KII74724.1 - 0.027 14.4 0.3 0.034 14.1 0.2 1.2 1 0 0 1 1 1 0 Testis-expressed 12 Adaptin_N PF01602.15 KII74725.1 - 1.1e-74 251.6 0.5 1.5e-74 251.2 0.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 KII74725.1 - 3.3e-23 82.1 0.0 8.6e-23 80.8 0.0 1.7 2 0 0 2 2 2 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 KII74725.1 - 3.8e-10 39.9 0.1 0.011 15.9 0.0 4.8 3 1 1 4 4 4 4 HEAT repeats HEAT PF02985.17 KII74725.1 - 2e-05 24.2 7.4 0.23 11.6 0.0 5.7 5 0 0 5 5 5 2 HEAT repeat Vac14_Fab1_bd PF12755.2 KII74725.1 - 7.1e-05 23.1 1.7 0.39 11.1 0.0 4.1 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 KII74725.1 - 0.00042 20.2 2.1 0.044 13.6 0.1 4.0 2 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 KII74725.1 - 0.0019 18.5 6.3 0.074 13.5 0.6 4.3 5 0 0 5 5 5 1 HEAT-like repeat Cnd3 PF12719.2 KII74725.1 - 0.012 14.6 0.1 0.057 12.4 0.0 2.2 1 1 1 2 2 2 0 Nuclear condensing complex subunits, C-term domain Vitellogenin_N PF01347.17 KII74725.1 - 0.029 12.6 0.3 0.099 10.8 0.0 1.8 2 0 0 2 2 2 0 Lipoprotein amino terminal region DUF1014 PF06244.7 KII74726.1 - 5.3e-22 78.3 4.3 7.3e-22 77.8 3.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1014) YABBY PF04690.8 KII74726.1 - 1.8e-08 34.7 1.2 2.4e-08 34.3 0.8 1.1 1 0 0 1 1 1 1 YABBY protein UPF0449 PF15136.1 KII74726.1 - 0.013 15.6 1.1 0.026 14.6 0.3 1.8 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 HMG_box PF00505.14 KII74726.1 - 0.026 14.7 0.5 0.048 13.9 0.4 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box HMG_box_2 PF09011.5 KII74726.1 - 0.1 12.9 1.3 0.19 12.0 0.9 1.4 1 0 0 1 1 1 0 HMG-box domain DUF1743 PF08489.6 KII74726.1 - 0.11 12.2 0.4 0.33 10.7 0.0 2.1 1 1 1 3 3 3 0 Domain of unknown function (DUF1743) MULE PF10551.4 KII74727.1 - 0.00032 20.8 0.0 0.00059 19.9 0.0 1.6 1 1 0 1 1 1 1 MULE transposase domain NDK PF00334.14 KII74728.1 - 1.1e-21 76.9 0.0 1.3e-21 76.7 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase RNase_T PF00929.19 KII74729.1 - 2.4e-27 96.2 0.0 3.5e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 KII74729.1 - 9.5e-05 21.9 0.0 0.00027 20.4 0.0 1.8 2 1 0 2 2 2 1 3'-5' exonuclease tRNA_SAD PF07973.9 KII74730.1 - 3.2e-05 23.7 0.0 8.6e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF754 PF05449.6 KII74731.1 - 0.38 10.7 3.1 13 5.8 0.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF754) GDI PF00996.13 KII74732.1 - 1.1e-13 50.2 0.1 1.7e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 GDP dissociation inhibitor Imm7 PF15588.1 KII74732.1 - 0.054 13.5 0.1 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 7 DUF3846 PF12957.2 KII74732.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3846) TRAM1 PF08390.6 KII74733.1 - 0.00029 20.2 0.0 0.00088 18.7 0.0 1.9 1 0 0 1 1 1 1 TRAM1-like protein Serpin PF00079.15 KII74734.1 - 1.9e-73 247.7 3.9 2.1e-73 247.6 2.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII74735.1 - 7.6e-33 114.1 5.7 9e-33 113.9 3.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3969 PF13108.1 KII74735.1 - 0.035 13.7 0.4 0.089 12.4 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3969) DUF3405 PF11885.3 KII74736.1 - 0.022 13.0 0.4 0.025 12.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) DUF1687 PF07955.6 KII74736.1 - 0.057 13.3 1.3 0.086 12.8 0.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1687) FliD_N PF02465.13 KII74736.1 - 1.4 9.3 9.4 0.34 11.3 0.7 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Gin PF10764.4 KII74738.1 - 0.047 13.3 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin DDE_3 PF13358.1 KII74739.1 - 1.6e-08 34.3 0.1 1.8e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Bac_chlorC PF02043.12 KII74739.1 - 0.015 15.0 0.1 0.021 14.6 0.1 1.5 1 1 0 1 1 1 0 Bacteriochlorophyll C binding protein Vezatin PF12632.2 KII74744.1 - 0.073 12.1 0.2 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes 4HB_MCP_1 PF12729.2 KII74744.1 - 0.085 12.2 0.3 0.11 11.8 0.2 1.1 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Ribosomal_S17 PF00366.15 KII74744.1 - 2.7 8.1 7.1 0.21 11.6 1.3 1.8 2 0 0 2 2 2 0 Ribosomal protein S17 rve PF00665.21 KII74745.1 - 0.0021 18.1 0.0 0.0023 18.0 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DUF3652 PF12372.3 KII74745.1 - 0.023 14.2 0.1 0.63 9.6 0.1 2.4 2 0 0 2 2 2 0 Huntingtin protein region Ephrin PF00812.12 KII74747.1 - 0.079 12.4 0.1 0.086 12.3 0.0 1.1 1 0 0 1 1 1 0 Ephrin rve PF00665.21 KII74749.1 - 1.3e-21 76.9 0.0 2.4e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74749.1 - 0.00096 18.6 0.1 0.002 17.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF257 PF03192.8 KII74750.1 - 0.085 12.1 0.1 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 Pyrococcus protein of unknown function, DUF257 DUF995 PF06191.7 KII74751.1 - 0.076 12.3 0.0 0.09 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF995) BNR PF02012.15 KII74754.1 - 0.0081 15.8 1.7 1.6 8.8 0.3 2.9 2 0 0 2 2 2 2 BNR/Asp-box repeat Dynein_light PF01221.13 KII74755.1 - 9.9e-26 89.5 0.2 1.2e-25 89.3 0.2 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 MFS_1 PF07690.11 KII74758.1 - 1.4e-24 86.4 21.6 7.5e-24 84.1 12.8 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily DDE_Tnp_IS1595 PF12762.2 KII74759.1 - 4.3e-25 88.3 0.0 5.3e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF3797 PF12677.2 KII74759.1 - 2 8.1 5.0 6.7 6.4 1.3 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF3797) DUF59 PF01883.14 KII74760.1 - 7.5e-05 22.6 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF59 CM_1 PF07736.6 KII74762.1 - 0.033 14.2 0.0 0.6 10.2 0.0 2.1 1 1 1 2 2 2 0 Chorismate mutase type I Ovate PF04844.8 KII74762.1 - 0.065 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Transcriptional repressor, ovate HPD PF05044.7 KII74762.1 - 0.082 12.5 1.5 0.13 11.9 1.0 1.3 1 0 0 1 1 1 0 Homeo-prospero domain EFG_II PF14492.1 KII74763.1 - 8.1e-26 89.6 0.1 1.1e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 KII74763.1 - 1.3e-23 82.7 0.0 2e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor G, domain IV THUMP PF02926.12 KII74763.1 - 0.11 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 THUMP domain FG-GAP PF01839.18 KII74765.1 - 0.073 12.7 0.4 0.13 12.0 0.3 1.4 1 0 0 1 1 1 0 FG-GAP repeat DNA_pol3_a_NII PF11490.3 KII74768.1 - 0.062 12.9 0.0 0.73 9.4 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Cnd2 PF05786.9 KII74769.1 - 6.6e-40 137.3 7.3 5.8e-26 91.2 0.2 2.5 3 0 0 3 3 3 2 Condensin complex subunit 2 THEG PF14912.1 KII74769.1 - 0.11 13.0 0.4 0.11 13.0 0.3 2.2 2 0 0 2 2 2 0 Testicular haploid expressed repeat Med30 PF11315.3 KII74770.1 - 0.03 14.4 1.2 0.037 14.1 0.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 30 GAS PF13851.1 KII74770.1 - 0.033 13.3 6.7 0.043 13.0 4.1 1.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding THOC7 PF05615.8 KII74770.1 - 0.04 14.1 2.5 0.048 13.9 1.8 1.2 1 0 0 1 1 1 0 Tho complex subunit 7 Myb_DNA-bind_4 PF13837.1 KII74770.1 - 0.25 11.4 4.4 0.19 11.8 1.7 1.8 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain IBR PF01485.16 KII74770.1 - 0.3 10.9 3.5 0.99 9.3 2.4 2.0 1 1 0 1 1 1 0 IBR domain YgaB PF14182.1 KII74770.1 - 1 9.6 7.1 2.1 8.6 1.3 2.3 1 1 1 2 2 2 0 YgaB-like protein MpPF1 PF07668.6 KII74774.1 - 0.023 13.9 0.2 0.031 13.4 0.2 1.2 1 0 0 1 1 1 0 M penetrans paralogue family 1 Syntaphilin PF15290.1 KII74775.1 - 0.11 11.9 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp RVT_1 PF00078.22 KII74776.1 - 7.1e-05 22.2 0.3 0.0001 21.7 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AIF_C PF14721.1 KII74777.1 - 0.077 13.2 0.1 0.085 13.1 0.0 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DinI PF06183.8 KII74778.1 - 3.2e-23 81.5 0.1 5.6e-23 80.7 0.1 1.4 1 0 0 1 1 1 1 DinI-like family RVT_1 PF00078.22 KII74779.1 - 8.4e-06 25.2 0.1 1.7e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII74780.1 - 0.018 15.1 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain BNR PF02012.15 KII74782.1 - 0.00073 18.9 5.6 1.4 9.0 0.0 3.9 4 0 0 4 4 4 3 BNR/Asp-box repeat BNR PF02012.15 KII74784.1 - 2.6e-05 23.3 1.0 1.5 8.9 0.0 4.0 3 0 0 3 3 3 3 BNR/Asp-box repeat Glyco_tranf_2_2 PF10111.4 KII74785.1 - 0.03 13.3 0.7 0.046 12.8 0.2 1.5 1 1 1 2 2 2 0 Glycosyltransferase like family 2 EST1 PF10374.4 KII74785.1 - 0.045 13.7 0.6 2.2 8.2 0.4 2.4 1 1 0 1 1 1 0 Telomerase activating protein Est1 FRG2 PF15315.1 KII74788.1 - 0.0045 16.9 0.1 0.0054 16.7 0.0 1.2 1 0 0 1 1 1 1 Facioscapulohumeral muscular dystrophy candidate 2 zf-CCCH PF00642.19 KII74792.1 - 2.3e-07 30.3 24.3 9e-05 22.0 1.1 4.0 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) OST3_OST6 PF04756.8 KII74793.1 - 1.1e-10 41.3 6.5 1.1e-10 41.3 4.5 1.9 2 0 0 2 2 2 1 OST3 / OST6 family DUF3290 PF11694.3 KII74793.1 - 0.29 10.8 2.3 11 5.8 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3290) VPS9 PF02204.13 KII74794.1 - 8.4e-25 86.8 0.1 1.5e-24 85.9 0.1 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain COG5 PF10392.4 KII74794.1 - 0.031 14.2 0.7 0.077 12.9 0.0 1.9 2 1 0 2 2 2 0 Golgi transport complex subunit 5 IncA PF04156.9 KII74794.1 - 0.32 10.5 2.4 0.18 11.3 0.3 1.5 2 0 0 2 2 2 0 IncA protein DUF1049 PF06305.6 KII74795.1 - 0.043 13.2 0.4 0.073 12.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) DDE_3 PF13358.1 KII74796.1 - 0.0061 16.3 0.0 0.0074 16.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Cytochrome_C554 PF13435.1 KII74799.1 - 0.13 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c554 and c-prime Tash_PEST PF07708.6 KII74802.1 - 0.065 13.1 3.8 0.16 11.9 2.6 1.6 1 0 0 1 1 1 0 Tash protein PEST motif HbrB PF08539.6 KII74802.1 - 0.1 12.4 0.1 0.23 11.2 0.0 1.5 2 0 0 2 2 2 0 HbrB-like SEA PF01390.15 KII74803.1 - 0.0012 18.5 0.0 0.0026 17.4 0.0 1.5 1 1 0 1 1 1 1 SEA domain RVT_1 PF00078.22 KII74804.1 - 4.6e-19 68.6 0.0 8.4e-19 67.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII74804.1 - 2.9e-14 53.2 0.0 7.4e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.5 KII74804.1 - 5.3e-06 25.7 0.2 1.4e-05 24.4 0.2 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RVP PF00077.15 KII74804.1 - 2.5e-05 24.1 0.0 6.8e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII74804.1 - 3.2e-05 23.6 11.4 0.013 15.4 1.9 2.7 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII74804.1 - 0.0026 18.2 0.1 0.0056 17.1 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII74804.1 - 0.013 15.2 0.0 0.063 13.0 0.0 2.2 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII74804.1 - 0.016 14.8 5.7 0.23 11.1 0.4 2.9 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.9 KII74804.1 - 0.045 13.6 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_6 PF15288.1 KII74804.1 - 0.17 11.5 12.6 1.2 8.8 0.8 2.7 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.1 KII74807.1 - 5.3e-32 110.5 0.0 6.7e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII74807.1 - 6.8e-05 22.9 0.0 0.0001 22.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HeH PF12949.2 KII74811.1 - 0.049 13.1 0.0 0.17 11.4 0.0 1.9 2 0 0 2 2 2 0 HeH/LEM domain DUF4208 PF13907.1 KII74813.1 - 0.054 13.7 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) DUF4504 PF14953.1 KII74815.1 - 0.11 11.8 1.5 0.15 11.3 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4504) Vinculin PF01044.14 KII74816.1 - 3.3e-19 68.4 23.8 1.3e-18 66.5 16.5 2.0 1 1 0 1 1 1 1 Vinculin family EcsC PF12787.2 KII74816.1 - 0.026 13.9 0.4 0.026 13.9 0.3 3.1 4 0 0 4 4 4 0 EcsC protein family Herpes_UL3 PF03369.8 KII74816.1 - 0.028 14.4 3.4 0.039 13.9 1.4 2.0 2 0 0 2 2 2 0 Herpesvirus UL3 protein Sec23_helical PF04815.10 KII74816.1 - 0.054 12.9 3.3 6.4 6.2 0.0 4.0 2 1 1 3 3 3 0 Sec23/Sec24 helical domain Glyoxalase_2 PF12681.2 KII74817.1 - 0.023 15.2 0.0 0.026 15.1 0.0 1.1 1 0 0 1 1 1 0 Glyoxalase-like domain ApoO PF09769.4 KII74818.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.5 1 1 0 1 1 1 0 Apolipoprotein O Porin_1 PF00267.16 KII74826.1 - 3.8e-69 233.5 11.9 4.3e-69 233.3 8.3 1.0 1 0 0 1 1 1 1 Gram-negative porin Laminin_N PF00055.12 KII74829.1 - 0.0027 16.7 4.6 0.0044 16.0 3.0 1.6 1 1 0 1 1 1 1 Laminin N-terminal (Domain VI) zf-met PF12874.2 KII74829.1 - 0.0061 16.7 3.0 1.7 8.9 0.6 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 KII74829.1 - 0.08 13.3 6.3 3.1 8.3 0.4 2.5 2 1 0 2 2 2 0 C2H2-type zinc finger YdjO PF14169.1 KII74829.1 - 0.082 12.3 4.2 1.4 8.4 0.3 2.5 2 1 0 2 2 2 0 Cold-inducible protein YdjO DUF4432 PF14486.1 KII74829.1 - 0.13 10.8 0.0 0.14 10.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) DUF581 PF04570.9 KII74829.1 - 0.2 10.9 2.5 7.8 5.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF581) HNH_5 PF14279.1 KII74829.1 - 1.1 9.3 5.3 1.9 8.5 3.7 1.5 1 0 0 1 1 1 0 HNH endonuclease zf-BED PF02892.10 KII74829.1 - 9.2 6.1 8.1 5 6.9 2.3 2.2 1 1 1 2 2 2 0 BED zinc finger RVT_1 PF00078.22 KII74830.1 - 7.3e-08 32.0 0.0 8.2e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_6 PF13912.1 KII74832.1 - 0.0027 17.5 0.0 0.012 15.4 0.0 2.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.2 KII74832.1 - 0.072 13.3 0.0 0.32 11.2 0.0 2.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 KII74832.1 - 0.15 12.4 1.4 3.2 8.2 0.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger HNH_5 PF14279.1 KII74832.1 - 7.2 6.6 7.8 3.5 7.7 3.1 2.2 2 0 0 2 2 2 0 HNH endonuclease RVT_1 PF00078.22 KII74833.1 - 1.1e-07 31.4 0.2 1.5e-07 31.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII74834.1 - 1.7e-09 37.5 0.0 3.8e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.22 KII74834.1 - 1.5e-08 34.2 0.1 3.8e-08 32.9 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.18 KII74834.1 - 9.2e-06 25.3 10.1 0.001 18.8 1.5 2.7 2 0 0 2 2 2 2 Zinc knuckle Asp_protease PF09668.5 KII74834.1 - 0.00015 21.3 0.0 0.00061 19.3 0.0 2.1 2 1 0 2 2 2 1 Aspartyl protease Asp_protease_2 PF13650.1 KII74834.1 - 0.0025 18.2 0.0 0.0051 17.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Spuma_A9PTase PF03539.9 KII74834.1 - 0.018 14.9 0.1 0.049 13.5 0.0 1.7 1 1 1 2 2 2 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII74834.1 - 0.047 13.5 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII74834.1 - 0.1 12.2 4.9 0.18 11.5 0.1 2.7 2 0 0 2 2 2 0 Zinc knuckle Apc4 PF12896.2 KII74834.1 - 0.11 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 PDGF_N PF04692.8 KII74834.1 - 0.13 12.8 0.4 0.77 10.2 0.0 2.3 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region zf-CCHC_3 PF13917.1 KII74834.1 - 0.14 11.9 11.2 0.28 10.9 1.3 2.6 1 1 1 2 2 2 0 Zinc knuckle rve PF00665.21 KII74835.1 - 6.4e-24 84.3 0.0 7.6e-24 84.1 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74835.1 - 0.00053 19.4 0.0 0.0014 18.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 KII74835.1 - 0.041 13.8 0.0 0.047 13.6 0.0 1.1 1 0 0 1 1 1 0 DDE domain Transcript_VP30 PF11507.3 KII74835.1 - 0.047 13.5 0.0 0.24 11.2 0.0 1.9 1 1 1 2 2 2 0 Ebola virus-specific transcription factor VP30 AT_hook PF02178.14 KII74836.1 - 0.86 9.4 7.7 1.7 8.5 5.4 1.6 1 0 0 1 1 1 0 AT hook motif RVT_1 PF00078.22 KII74837.1 - 2.1e-24 86.0 0.0 4.2e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII74837.1 - 1.1e-07 31.6 0.0 2.6e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.21 KII74837.1 - 0.00019 21.5 0.0 0.0014 18.7 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain Asp_protease_2 PF13650.1 KII74837.1 - 0.011 16.1 0.0 0.03 14.8 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.1 KII74837.1 - 0.18 11.6 0.0 0.41 10.4 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DDE_3 PF13358.1 KII74838.1 - 4.2e-07 29.8 0.0 5e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RB_B PF01857.15 KII74838.1 - 0.13 11.7 1.6 0.17 11.4 0.5 1.6 1 1 1 2 2 2 0 Retinoblastoma-associated protein B domain BURP PF03181.10 KII74839.1 - 0.054 12.6 0.2 0.054 12.6 0.1 1.2 1 0 0 1 1 1 0 BURP domain zf-Apc11 PF12861.2 KII74840.1 - 0.29 10.9 2.2 3.8 7.4 1.5 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RVT_1 PF00078.22 KII74843.1 - 1.8e-07 30.7 0.0 2.3e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Phage_connect_1 PF05135.8 KII74846.1 - 0.19 11.9 5.8 0.12 12.5 0.4 3.0 3 1 0 3 3 3 0 Phage gp6-like head-tail connector protein Kelch_6 PF13964.1 KII74848.1 - 2e-15 56.2 9.1 9.2e-06 25.6 0.2 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII74848.1 - 5.1e-15 54.7 8.7 5.9e-07 28.9 0.5 3.1 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII74848.1 - 8.8e-12 44.8 2.1 0.00014 21.9 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII74848.1 - 5.1e-11 42.1 3.7 0.00044 19.9 0.1 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII74848.1 - 7.2e-06 25.5 7.5 0.16 11.7 0.1 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII74848.1 - 0.012 15.5 6.6 3.4 7.7 0.2 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.1 KII74849.1 - 0.0065 16.2 0.4 3.2 7.6 0.0 2.4 1 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII74849.1 - 0.0085 16.2 0.3 3.4 7.9 0.1 2.5 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII74849.1 - 0.22 11.1 7.1 0.18 11.3 0.7 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.1 KII74849.1 - 0.59 10.4 3.5 20 5.5 0.6 2.7 1 1 1 2 2 2 0 Kelch motif Kelch_1 PF01344.20 KII74852.1 - 1.7e-15 56.2 6.8 4.3e-05 22.9 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 KII74852.1 - 1.7e-15 56.3 5.9 7.5e-07 29.0 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII74852.1 - 3.4e-12 46.1 3.2 7.1e-05 22.8 0.0 3.9 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII74852.1 - 3.2e-10 39.5 7.1 0.0075 16.0 0.0 3.8 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII74852.1 - 4.3e-07 29.4 2.5 0.0043 16.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 KII74852.1 - 0.00011 22.1 4.0 0.32 10.9 0.1 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 KII74853.1 - 1.4e-05 25.0 0.1 0.00037 20.5 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.20 KII74853.1 - 2e-05 24.0 0.6 0.037 13.5 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 KII74853.1 - 0.00039 20.4 0.3 0.72 10.1 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII74853.1 - 0.0019 17.8 1.2 0.15 11.8 0.4 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.1 KII74853.1 - 0.006 16.3 4.3 0.0093 15.7 0.7 2.2 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.1 KII74853.1 - 0.053 13.4 2.2 1.9 8.5 0.0 3.4 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.1 KII74855.1 - 6.6e-09 35.5 6.2 0.0017 18.4 0.4 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII74855.1 - 9.1e-07 28.5 3.0 0.0044 16.7 0.2 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KII74855.1 - 2.2e-06 27.6 1.5 0.0018 18.4 0.0 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII74855.1 - 0.0008 19.0 4.0 0.049 13.4 0.0 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.1 KII74855.1 - 0.01 15.7 5.1 0.071 13.0 0.4 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.20 KII74855.1 - 0.16 11.5 8.1 10 5.7 1.6 3.7 3 1 0 3 3 3 0 Kelch motif DDE_3 PF13358.1 KII74856.1 - 4.4e-17 62.1 0.0 4.8e-17 62.0 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_6 PF13964.1 KII74857.1 - 3.3e-16 58.6 10.4 0.0028 17.7 0.0 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_3 PF13415.1 KII74857.1 - 1.2e-14 53.9 1.2 1.3e-06 28.4 0.0 5.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.1 KII74857.1 - 6.7e-10 38.5 6.1 0.014 15.1 0.1 5.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KII74857.1 - 3.8e-07 29.5 21.8 0.32 10.5 0.1 5.9 6 0 0 6 6 6 4 Kelch motif rve PF00665.21 KII74858.1 - 2.6e-22 79.1 0.0 5e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74858.1 - 0.0078 15.7 0.0 0.02 14.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain SynMuv_product PF06047.6 KII74858.1 - 0.14 11.8 1.0 2.6 7.8 0.0 2.4 2 0 0 2 2 2 0 Ras-induced vulval development antagonist Kelch_6 PF13964.1 KII74860.1 - 2.9e-17 62.0 3.7 2.6e-06 27.3 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII74860.1 - 2.7e-11 43.2 0.2 0.00027 21.0 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.20 KII74860.1 - 4.6e-10 38.8 15.3 1.3e-06 27.8 0.9 3.4 3 1 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII74860.1 - 2.3e-08 33.6 2.5 0.0039 16.9 0.0 3.5 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KII74860.1 - 5.6e-06 26.1 3.0 0.00019 21.3 0.0 3.0 3 1 0 3 3 3 1 Kelch motif Kelch_2 PF07646.10 KII74860.1 - 2.9e-05 23.6 1.9 0.084 12.6 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Rax2 PF12768.2 KII74860.1 - 0.00015 21.0 1.6 0.017 14.3 0.1 2.1 1 1 1 2 2 2 2 Cortical protein marker for cell polarity Atx10homo_assoc PF09759.4 KII74861.1 - 0.005 16.5 0.0 0.037 13.7 0.0 2.0 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain DUF1778 PF08681.6 KII74864.1 - 0.0021 17.8 0.0 0.0045 16.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1778) DUF3950 PF13132.1 KII74864.1 - 0.037 13.5 0.2 0.037 13.5 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3950) Sulfate_transp PF00916.15 KII74865.1 - 2e-73 246.8 13.9 1.6e-72 243.8 8.6 2.5 1 1 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KII74865.1 - 1.2e-21 76.1 4.6 1.2e-21 76.1 3.2 3.3 3 1 0 3 3 3 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 KII74865.1 - 1.9e-11 43.3 0.1 3.2e-11 42.6 0.1 1.3 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 KII74865.1 - 0.0015 18.4 0.0 0.0035 17.3 0.0 1.7 1 0 0 1 1 1 1 STAS domain GGDEF PF00990.16 KII74866.1 - 8.3e-39 132.7 0.0 9e-39 132.6 0.0 1.0 1 0 0 1 1 1 1 GGDEF domain DUF249 PF03158.8 KII74866.1 - 0.07 12.6 0.3 0.11 12.0 0.2 1.3 1 0 0 1 1 1 0 Multigene family 530 protein SIS PF01380.17 KII74867.1 - 9.7e-49 164.3 0.3 7.1e-29 100.0 0.0 2.6 2 0 0 2 2 2 2 SIS domain SIS_2 PF13580.1 KII74867.1 - 0.02 14.6 0.0 0.082 12.6 0.0 2.0 2 0 0 2 2 2 0 SIS domain Spermine_synth PF01564.12 KII74868.1 - 2.7e-86 288.5 0.1 6.5e-86 287.2 0.0 1.7 2 0 0 2 2 2 1 Spermine/spermidine synthase AdoMet_dc PF02675.10 KII74868.1 - 9.8e-35 118.6 0.0 2.6e-34 117.3 0.0 1.7 1 0 0 1 1 1 1 S-adenosylmethionine decarboxylase Methyltransf_18 PF12847.2 KII74868.1 - 2.9e-07 31.0 0.0 1.3e-06 28.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 KII74868.1 - 1.1e-05 25.4 0.0 2.6e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KII74868.1 - 3e-05 23.6 0.0 0.00014 21.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KII74868.1 - 0.0017 17.7 0.0 0.0037 16.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 KII74868.1 - 0.002 18.5 0.0 0.008 16.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain LPP PF04728.8 KII74868.1 - 0.056 13.2 0.0 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 Lipoprotein leucine-zipper TraP PF07296.6 KII74868.1 - 0.077 11.9 0.2 0.57 9.1 0.0 2.1 2 0 0 2 2 2 0 TraP protein Methyltransf_12 PF08242.7 KII74868.1 - 0.11 13.0 0.0 0.46 10.9 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain DUF2416 PF10315.4 KII74871.1 - 0.022 14.9 0.0 0.031 14.5 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2416) rve PF00665.21 KII74872.1 - 1.8e-06 28.0 0.0 3.2e-06 27.2 0.0 1.4 2 0 0 2 2 2 1 Integrase core domain Spore-coat_CotZ PF10612.4 KII74872.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Spore coat protein Z DUF3911 PF13050.1 KII74873.1 - 0.045 13.8 0.2 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3911) SHP PF03579.8 KII74873.1 - 0.17 11.2 4.5 0.26 10.6 2.2 2.0 2 0 0 2 2 2 0 Small hydrophobic protein FLYWCH PF04500.11 KII74874.1 - 1.8e-08 34.1 1.0 2.9e-08 33.4 0.7 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain DUF3330 PF11809.3 KII74875.1 - 0.0047 16.7 0.9 0.0066 16.2 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3330) Pox_E8 PF03394.8 KII74875.1 - 0.055 12.8 0.2 0.061 12.6 0.1 1.1 1 0 0 1 1 1 0 Poxvirus E8 protein DUF3678 PF12435.3 KII74875.1 - 3.5 7.2 6.3 15 5.2 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Kelch_6 PF13964.1 KII74876.1 - 4.9e-06 26.4 8.5 0.013 15.6 0.2 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 KII74876.1 - 5.7e-06 26.0 13.4 0.011 15.4 0.3 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII74876.1 - 7.8e-05 22.7 6.9 0.0024 17.9 0.0 3.4 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.1 KII74876.1 - 0.00074 19.4 9.3 0.084 12.8 1.5 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 KII74876.1 - 0.007 15.8 8.9 0.27 10.8 0.8 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 KII74876.1 - 1.4 8.7 9.1 7.8 6.4 0.3 3.3 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 KII74877.1 - 1.8e-14 53.1 4.6 3.2e-05 23.8 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII74877.1 - 4.7e-09 35.6 8.3 6.5e-06 25.5 0.1 4.0 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 KII74877.1 - 2.8e-07 30.1 10.3 0.0013 18.4 0.2 4.1 3 2 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KII74877.1 - 3.1e-06 27.1 2.3 0.041 14.0 0.1 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KII74877.1 - 2.1e-05 24.3 0.9 0.015 15.2 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 KII74877.1 - 0.0081 15.8 8.4 0.03 14.0 0.7 3.5 3 2 0 3 3 3 1 Kelch motif Kelch_6 PF13964.1 KII74878.1 - 4.9e-11 42.3 5.2 0.0002 21.3 0.1 3.2 1 1 2 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII74878.1 - 6.7e-08 31.9 3.8 0.004 16.6 0.0 3.6 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 KII74878.1 - 7.2e-08 32.3 0.5 0.33 11.1 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII74878.1 - 1.1e-06 28.3 3.3 0.013 15.2 0.0 4.1 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII74878.1 - 0.00029 20.4 0.6 2.4 8.0 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 KII74878.1 - 0.00099 19.0 1.0 0.15 12.0 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 KII74879.1 - 1.2e-17 63.1 13.8 4.8e-07 29.2 0.8 3.1 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 KII74879.1 - 2.1e-17 62.4 9.1 3.3e-06 27.0 0.4 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII74879.1 - 2.3e-13 49.8 8.8 0.00078 19.5 0.0 3.9 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII74879.1 - 4.1e-13 48.8 4.5 0.00068 19.3 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII74879.1 - 8.4e-10 38.0 5.5 0.00017 21.1 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.1 KII74879.1 - 9.3e-10 38.2 6.1 3.1e-05 23.8 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 KII74880.1 - 1.1e-21 76.0 22.1 6.3e-05 22.9 0.2 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KII74880.1 - 1.1e-21 76.2 18.3 1.5e-05 24.6 0.0 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.20 KII74880.1 - 6.8e-15 54.3 25.5 2.7e-05 23.6 1.3 6.8 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.1 KII74880.1 - 7.1e-15 54.7 16.9 0.00052 20.1 0.8 6.9 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KII74880.1 - 1.2e-11 44.2 16.7 2.9e-05 23.8 0.0 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 KII74880.1 - 2.9e-05 23.6 15.4 0.43 10.4 0.0 5.7 6 0 0 6 6 6 3 Kelch motif C1_3 PF07649.7 KII74881.1 - 0.13 12.2 1.3 0.25 11.4 0.3 2.0 2 0 0 2 2 2 0 C1-like domain Glyco_transf_21 PF13506.1 KII74882.1 - 1.9e-10 40.2 0.0 2.6e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.1 KII74882.1 - 5.3e-10 39.4 0.0 6.7e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 KII74882.1 - 6.6e-06 25.9 0.7 1.5e-05 24.7 0.5 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 DDE_Tnp_IS1595 PF12762.2 KII74884.1 - 1.4e-10 41.2 0.0 1.7e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DiS_P_DiS PF06750.8 KII74884.1 - 0.11 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain LCAT PF02450.10 KII74886.1 - 1e-43 149.8 0.6 1.2e-33 116.6 0.1 2.1 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 KII74886.1 - 4.5e-05 23.4 0.0 6.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 KII74886.1 - 0.00014 21.4 0.0 0.00039 20.0 0.0 1.7 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_5 PF12695.2 KII74886.1 - 0.0088 15.8 0.0 0.023 14.4 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF915 PF06028.6 KII74886.1 - 0.018 14.1 0.0 0.064 12.3 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.15 KII74886.1 - 0.13 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Hen1_L PF12623.2 KII74888.1 - 0.03 13.0 0.0 0.047 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA repair, ligase-Pnkp-associating, region of Hen1 RE_TaqI PF09573.5 KII74888.1 - 0.094 11.8 0.3 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 TaqI restriction endonuclease HipA_C PF07804.7 KII74889.1 - 0.058 13.5 0.0 0.36 10.9 0.0 1.9 2 0 0 2 2 2 0 HipA-like C-terminal domain Imm35 PF15581.1 KII74889.1 - 0.087 12.8 0.5 0.85 9.6 0.1 2.0 1 1 1 2 2 2 0 Immunity protein 35 Fcf1 PF04900.7 KII74889.1 - 0.096 12.7 1.4 6.2 6.9 0.1 2.1 1 1 1 2 2 2 0 Fcf1 Pkinase PF00069.20 KII74891.1 - 4.9e-50 170.1 0.2 3.1e-37 128.1 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KII74891.1 - 2.1e-28 99.0 0.1 1.4e-21 76.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KII74891.1 - 0.00036 19.5 0.0 0.0007 18.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like FRQ PF09421.5 KII74891.1 - 0.0096 13.7 2.4 0.015 13.1 0.1 2.0 2 0 0 2 2 2 1 Frequency clock protein PQQ_2 PF13360.1 KII74891.1 - 0.013 14.9 0.0 0.043 13.2 0.0 1.8 1 1 0 1 1 1 0 PQQ-like domain PQQ PF01011.16 KII74891.1 - 0.03 13.8 0.0 0.29 10.7 0.0 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat BNR PF02012.15 KII74894.1 - 3.9e-05 22.8 0.5 0.81 9.7 0.0 4.0 3 0 0 3 3 3 3 BNR/Asp-box repeat DDE_3 PF13358.1 KII74895.1 - 8.1e-15 54.8 0.1 9.2e-15 54.6 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Tenui_NCP PF04876.7 KII74895.1 - 0.015 14.8 0.2 0.017 14.6 0.1 1.1 1 0 0 1 1 1 0 Tenuivirus major non-capsid protein rve PF00665.21 KII74895.1 - 0.12 12.4 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Integrase core domain Ldl_recept_a PF00057.13 KII74896.1 - 1.4e-08 34.4 7.9 1.4e-08 34.4 5.5 3.4 3 1 1 4 4 4 2 Low-density lipoprotein receptor domain class A Ribosomal_L7Ae PF01248.21 KII74898.1 - 7.3e-11 41.4 0.1 2.2e-10 39.9 0.0 1.7 1 1 1 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DAGK_cat PF00781.19 KII74898.1 - 0.0091 15.4 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain UDPG_MGDP_dh PF00984.14 KII74898.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Vps52 PF04129.7 KII74899.1 - 4.1e-25 88.2 12.0 8.2e-25 87.2 8.3 1.4 1 0 0 1 1 1 1 Vps52 / Sac2 family Ldl_recept_a PF00057.13 KII74900.1 - 5.6e-06 26.1 13.7 5.6e-06 26.1 9.5 2.9 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A DUF1856 PF08983.5 KII74901.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1856) Atg8 PF02991.11 KII74902.1 - 1.2e-08 34.8 0.0 1.4e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Cyclin_N PF00134.18 KII74903.1 - 7.6e-30 103.0 2.0 5.2e-28 97.1 0.2 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 KII74903.1 - 6.6e-24 84.1 0.3 1.2e-23 83.2 0.2 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Alpha-amylase PF00128.19 KII74904.1 - 0.0091 15.4 2.4 0.011 15.2 0.0 2.0 2 0 0 2 2 2 1 Alpha amylase, catalytic domain FERM_N PF09379.5 KII74904.1 - 0.059 13.4 1.3 0.94 9.5 0.9 2.5 1 1 0 1 1 1 0 FERM N-terminal domain LTD PF00932.14 KII74906.1 - 0.013 15.5 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Lamin Tail Domain SNAP PF14938.1 KII74907.1 - 1.6e-05 24.2 0.0 2.6e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII74907.1 - 0.094 12.6 0.3 0.15 11.9 0.2 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat NSF PF02071.15 KII74907.1 - 0.19 12.3 4.4 1.6 9.6 0.5 3.3 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat rve PF00665.21 KII74908.1 - 9.8e-28 96.6 0.0 2.8e-27 95.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.22 KII74908.1 - 5.2e-24 84.7 0.0 9.4e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.5 KII74908.1 - 6.6e-06 25.4 0.2 1.7e-05 24.0 0.2 1.8 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger RVP PF00077.15 KII74908.1 - 2.1e-05 24.3 0.1 5.2e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII74908.1 - 4.8e-05 23.0 11.4 0.016 15.1 1.9 2.8 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.1 KII74908.1 - 0.0022 18.4 0.1 0.0046 17.4 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII74908.1 - 0.019 14.7 0.0 0.08 12.7 0.0 2.1 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.1 KII74908.1 - 0.024 14.2 5.7 0.28 10.8 0.4 2.9 2 0 0 2 2 2 0 Zinc knuckle rve_3 PF13683.1 KII74908.1 - 0.049 13.1 0.0 0.15 11.6 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain Spuma_A9PTase PF03539.9 KII74908.1 - 0.052 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_6 PF15288.1 KII74908.1 - 0.28 10.8 12.6 1.5 8.5 0.8 2.7 2 0 0 2 2 2 0 Zinc knuckle DUF4588 PF15251.1 KII74910.1 - 0.76 9.7 5.1 1 9.2 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) DUF605 PF04652.11 KII74910.1 - 0.76 9.1 7.5 0.92 8.8 5.2 1.1 1 0 0 1 1 1 0 Vta1 like DDE_3 PF13358.1 KII74912.1 - 0.0062 16.2 0.0 0.01 15.6 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Serpin PF00079.15 KII74917.1 - 1.7e-47 162.3 3.2 1.9e-47 162.1 2.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII74919.1 - 0.00025 20.3 0.0 0.00025 20.2 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_Tnp_IS1595 PF12762.2 KII74920.1 - 1.3e-16 60.7 0.0 2.6e-16 59.7 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII74920.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family Annexin PF00191.15 KII74921.1 - 2.3e-18 65.8 3.6 9.2e-08 31.8 0.1 3.4 4 0 0 4 4 4 3 Annexin HTH_Tnp_Tc5 PF03221.11 KII74924.1 - 8.4e-06 25.5 2.7 3.1e-05 23.6 1.9 2.0 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 KII74924.1 - 0.00064 19.0 0.3 0.0013 18.1 0.2 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_1 PF03184.14 KII74924.1 - 0.012 14.7 0.2 0.068 12.3 0.0 2.0 1 1 1 2 2 2 0 DDE superfamily endonuclease HTH_38 PF13936.1 KII74924.1 - 0.02 14.4 0.2 0.35 10.4 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.1 KII74924.1 - 0.091 12.4 0.6 0.35 10.5 0.0 2.2 3 0 0 3 3 3 0 Homeodomain-like domain Dynamin_N PF00350.18 KII74926.1 - 2.3e-18 66.5 0.0 5.5e-17 62.0 0.0 2.3 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KII74926.1 - 5.1e-11 42.5 0.1 4.2e-10 39.5 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KII74926.1 - 4.5e-06 26.2 0.1 3.9e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KII74926.1 - 0.00012 21.2 0.0 0.00045 19.4 0.0 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KII74926.1 - 0.0012 19.3 0.0 0.0079 16.6 0.0 2.4 3 0 0 3 3 3 1 Miro-like protein FeoB_N PF02421.13 KII74926.1 - 0.007 15.6 0.0 0.46 9.7 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_28 PF13521.1 KII74926.1 - 0.034 14.0 0.0 0.079 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 KII74926.1 - 0.035 13.7 0.1 0.085 12.5 0.1 1.7 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRPRB PF09439.5 KII74926.1 - 0.055 12.6 0.1 0.44 9.7 0.0 2.3 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AIG1 PF04548.11 KII74926.1 - 0.07 12.2 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 AIG1 family DUF258 PF03193.11 KII74926.1 - 0.084 12.0 0.0 0.55 9.4 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function, DUF258 L_biotic_typeA PF04604.8 KII74926.1 - 0.11 12.1 0.0 1 9.0 0.0 2.6 2 0 0 2 2 2 0 Type-A lantibiotic CH PF00307.26 KII74927.1 - 5.6e-12 45.6 0.2 5.3e-10 39.3 0.0 2.4 2 1 0 2 2 2 2 Calponin homology (CH) domain Ribosomal_L21p PF00829.16 KII74929.1 - 0.028 14.5 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal prokaryotic L21 protein SMC_N PF02463.14 KII74929.1 - 0.15 11.2 0.2 0.21 10.8 0.2 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain EF-hand_2 PF09068.6 KII74930.1 - 0.022 14.8 0.5 0.071 13.1 0.2 1.8 1 1 1 2 2 2 0 EF hand Sec5 PF15469.1 KII74930.1 - 0.058 13.1 0.2 2.2 7.9 0.1 2.1 2 0 0 2 2 2 0 Exocyst complex component Sec5 DHC_N1 PF08385.7 KII74930.1 - 0.13 10.5 3.8 0.72 8.1 1.3 2.0 2 0 0 2 2 2 0 Dynein heavy chain, N-terminal region 1 Adeno_hexon_C PF03678.9 KII74930.1 - 0.44 9.9 2.4 0.57 9.5 0.1 2.0 2 0 0 2 2 2 0 Hexon, adenovirus major coat protein, C-terminal domain YolD PF08863.5 KII74931.1 - 0.05 13.4 0.1 0.099 12.5 0.1 1.5 1 0 0 1 1 1 0 YolD-like protein Fun_ATP-synt_8 PF05933.8 KII74931.1 - 1.8 8.6 8.5 0.38 10.8 2.5 2.3 3 0 0 3 3 3 0 Fungal ATP synthase protein 8 (A6L) GSH_synth_ATP PF03917.12 KII74932.1 - 0.09 11.3 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain zf-DHHC PF01529.15 KII74933.1 - 7.6e-12 44.9 2.1 1e-11 44.5 1.5 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase MMS19_C PF12460.3 KII74934.1 - 3.2e-07 29.4 4.4 0.0016 17.2 0.3 3.2 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal HEAT PF02985.17 KII74934.1 - 1.4e-06 27.8 5.9 0.55 10.4 0.0 6.5 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.1 KII74934.1 - 5.4e-05 23.3 0.0 3.2 8.1 0.0 4.4 5 0 0 5 5 5 2 HEAT repeats IBN_N PF03810.14 KII74934.1 - 0.00035 20.4 0.3 0.0019 18.0 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_EZ PF13513.1 KII74934.1 - 0.00051 20.4 0.1 0.21 12.1 0.0 4.6 5 0 0 5 5 5 1 HEAT-like repeat RVT_1 PF00078.22 KII74935.1 - 0.00019 20.8 0.0 0.00026 20.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2183 PF09949.4 KII74936.1 - 0.014 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) SNAP PF14938.1 KII74937.1 - 3.8e-08 32.8 0.2 4.7e-08 32.5 0.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 KII74937.1 - 0.1 12.5 2.4 5.7 7.1 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KII74937.1 - 0.45 10.2 2.3 17 5.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat NSF PF02071.15 KII74937.1 - 7.8 7.5 5.9 32 5.7 0.0 3.3 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat CDC45 PF02724.9 KII74939.1 - 0.0016 16.5 3.6 0.0017 16.4 2.5 1.1 1 0 0 1 1 1 1 CDC45-like protein RRN3 PF05327.6 KII74939.1 - 0.027 12.5 4.2 0.036 12.1 2.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TIMELESS_C PF05029.8 KII74939.1 - 0.2 10.5 14.7 0.26 10.1 10.2 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region DUF1510 PF07423.6 KII74939.1 - 0.36 10.1 11.2 0.59 9.4 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DHHW PF14286.1 KII74939.1 - 0.39 9.9 4.0 0.68 9.1 2.8 1.4 1 0 0 1 1 1 0 DHHW protein Nop14 PF04147.7 KII74939.1 - 2.6 5.8 17.8 4.2 5.1 12.3 1.3 1 0 0 1 1 1 0 Nop14-like family Borrelia_P83 PF05262.6 KII74939.1 - 6.3 4.9 10.7 7.4 4.7 7.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Merozoite_SPAM PF07133.6 KII74939.1 - 6.8 6.5 17.0 16 5.3 11.8 1.6 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) HSP90 PF00183.13 KII74939.1 - 7.1 4.9 15.3 12 4.2 10.6 1.3 1 0 0 1 1 1 0 Hsp90 protein DUF1168 PF06658.7 KII74939.1 - 7.8 6.0 24.5 0.42 10.1 11.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) Sin_N PF04801.8 KII74940.1 - 0.0023 16.8 1.9 0.0023 16.8 1.3 2.0 2 0 0 2 2 2 1 Sin-like protein conserved region TIMELESS_C PF05029.8 KII74940.1 - 0.0083 15.1 4.3 0.0083 15.1 3.0 2.0 2 0 0 2 2 2 1 Timeless protein C terminal region DUF4363 PF14276.1 KII74940.1 - 4.9 6.8 6.2 7.9 6.2 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Prion_bPrPp PF11587.3 KII74942.1 - 0.23 11.1 1.2 0.44 10.2 0.9 1.4 1 0 0 1 1 1 0 Major prion protein bPrPp - N terminal DDE_3 PF13358.1 KII74943.1 - 6.4e-08 32.4 0.1 9.2e-08 31.9 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Evr1_Alr PF04777.8 KII74943.1 - 0.016 15.1 0.2 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Erv1 / Alr family Peptidase_C1 PF00112.18 KII74944.1 - 4e-76 255.7 3.0 5.5e-76 255.2 2.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KII74944.1 - 2.8e-10 40.3 0.2 5.9e-10 39.2 0.1 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KII74944.1 - 2.4e-07 29.6 1.1 3.3e-05 22.6 0.2 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Syntaxin PF00804.20 KII74945.1 - 0.0052 16.9 1.1 0.0078 16.3 0.7 1.2 1 0 0 1 1 1 1 Syntaxin HisKA_2 PF07568.7 KII74945.1 - 0.034 13.9 0.2 0.068 13.0 0.1 1.6 1 0 0 1 1 1 0 Histidine kinase Syntaxin PF00804.20 KII74946.1 - 0.0051 16.9 1.1 0.0078 16.3 0.7 1.2 1 0 0 1 1 1 1 Syntaxin HisKA_2 PF07568.7 KII74946.1 - 0.033 14.0 0.2 0.066 13.0 0.1 1.6 1 0 0 1 1 1 0 Histidine kinase E1_DerP2_DerF2 PF02221.10 KII74947.1 - 7.5e-07 29.4 0.5 1.1e-06 28.9 0.3 1.2 1 0 0 1 1 1 1 ML domain E1_DerP2_DerF2 PF02221.10 KII74948.1 - 7e-07 29.5 0.1 1e-06 29.0 0.1 1.3 1 0 0 1 1 1 1 ML domain PaaA_PaaC PF05138.7 KII74949.1 - 0.053 12.4 0.0 0.058 12.3 0.0 1.1 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein Ribosomal_S3Ae PF01015.13 KII74954.1 - 1.3e-61 207.2 3.9 1.6e-61 207.0 2.7 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Ins134_P3_kin PF05770.6 KII74955.1 - 9.9e-39 133.1 0.4 1.2e-38 132.9 0.3 1.0 1 0 0 1 1 1 1 Inositol 1, 3, 4-trisphosphate 5/6-kinase TMEM154 PF15102.1 KII74956.1 - 0.016 14.8 0.1 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Podoplanin PF05808.6 KII74956.1 - 0.044 13.3 0.3 0.056 13.0 0.2 1.2 1 0 0 1 1 1 0 Podoplanin Arabinose_Isome PF02610.10 KII74956.1 - 0.054 12.4 0.1 0.12 11.3 0.0 1.6 2 0 0 2 2 2 0 L-arabinose isomerase WSS_VP PF12175.3 KII74956.1 - 0.14 11.2 5.6 1 8.4 1.7 2.3 2 0 0 2 2 2 0 White spot syndrome virus structural envelope protein VP AAA PF00004.24 KII74957.1 - 0.13 12.4 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) rve PF00665.21 KII74958.1 - 1.3e-25 89.7 0.0 2.3e-25 89.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 KII74958.1 - 1.9e-05 24.1 0.0 3.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.1 KII74958.1 - 0.06 13.0 0.0 0.14 11.8 0.0 1.7 1 1 0 1 1 1 0 DDE superfamily endonuclease DUF3993 PF13158.1 KII74959.1 - 0.036 13.8 0.4 0.2 11.4 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3993) Arch_ATPase PF01637.13 KII74959.1 - 0.17 11.5 2.4 0.24 11.0 1.7 1.2 1 0 0 1 1 1 0 Archaeal ATPase DDE_3 PF13358.1 KII74961.1 - 3.9e-10 39.6 0.0 5.7e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Serpin PF00079.15 KII74965.1 - 2.8e-21 76.0 0.5 3.4e-21 75.8 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-C2H2_4 PF13894.1 KII74966.1 - 0.00017 21.6 12.1 0.13 12.6 0.0 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_5 PF13909.1 KII74966.1 - 0.0017 18.4 2.3 0.027 14.6 0.0 3.4 2 1 0 2 2 2 1 C2H2-type zinc-finger domain zf-Di19 PF05605.7 KII74966.1 - 0.021 14.9 1.7 0.028 14.5 0.0 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-met2 PF12907.2 KII74966.1 - 0.072 13.0 1.0 0.22 11.5 0.7 1.9 1 0 0 1 1 1 0 Zinc-binding zf-TRAF PF02176.13 KII74966.1 - 0.14 12.5 9.4 0.33 11.3 3.2 2.4 2 0 0 2 2 2 0 TRAF-type zinc finger zf-H2C2_2 PF13465.1 KII74966.1 - 0.86 10.0 17.4 1.8 8.9 0.1 4.2 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2 PF00096.21 KII74966.1 - 1 9.8 0.0 1 9.8 0.0 4.2 4 1 0 4 4 4 0 Zinc finger, C2H2 type DDE_Tnp_IS1595 PF12762.2 KII74967.1 - 1e-06 28.6 0.0 1.1e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Peptidase_S15 PF02129.13 KII74967.1 - 0.13 11.6 0.0 0.16 11.3 0.0 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Plasmid_parti PF01672.11 KII74968.1 - 0.058 13.8 0.1 0.094 13.1 0.1 1.4 1 0 0 1 1 1 0 Putative plasmid partition protein Zot PF05707.7 KII74974.1 - 0.025 14.0 0.0 0.026 13.9 0.0 1.1 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) SNAP PF14938.1 KII74975.1 - 2.6e-10 39.9 0.4 3.2e-10 39.6 0.3 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP MIT PF04212.13 KII74975.1 - 0.00058 19.6 0.3 2.2 8.2 0.0 3.0 1 1 2 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 KII74975.1 - 0.0037 17.1 0.1 0.0051 16.7 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 KII74975.1 - 0.021 14.6 0.6 1.3 9.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat UCR_UQCRX_QCR9 PF05365.7 KII74975.1 - 0.032 13.8 0.1 0.079 12.6 0.1 1.7 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like TPR_11 PF13414.1 KII74975.1 - 0.072 12.7 0.3 0.13 11.9 0.2 1.4 1 0 0 1 1 1 0 TPR repeat NSF PF02071.15 KII74975.1 - 0.097 13.2 2.1 9.4 7.3 0.0 3.8 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat Metallothi_Euk2 PF12809.2 KII74975.1 - 0.12 12.7 1.1 0.18 12.1 0.8 1.3 1 0 0 1 1 1 0 Eukaryotic metallothionein TPR_1 PF00515.23 KII74975.1 - 0.22 11.1 1.0 12 5.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat CBP PF12192.3 KII74975.1 - 0.29 11.1 2.7 0.31 11.0 0.5 2.1 2 1 0 2 2 2 0 Fungal calcium binding protein Tetraspannin PF00335.15 KII74976.1 - 2.5 7.3 12.4 3.4 6.8 8.6 1.2 1 0 0 1 1 1 0 Tetraspanin family CbiQ PF02361.11 KII74976.1 - 6.7 6.2 11.2 2.9 7.4 6.3 1.4 1 1 0 1 1 1 0 Cobalt transport protein RE_AlwI PF09491.5 KII74978.1 - 0.0043 15.6 0.3 0.0057 15.1 0.2 1.2 1 1 0 1 1 1 1 AlwI restriction endonuclease Kunitz_BPTI PF00014.18 KII74979.1 - 4.2e-07 30.0 13.4 5.5e-05 23.2 3.3 2.5 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain SAC3 PF12209.3 KII74980.1 - 0.049 13.7 2.6 0.087 12.9 0.3 2.2 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain DUF287 PF03384.9 KII74983.1 - 0.059 13.5 1.0 0.39 10.9 0.1 2.2 2 0 0 2 2 2 0 Drosophila protein of unknown function, DUF287 UAA PF08449.6 KII74984.1 - 7.2e-07 28.4 1.3 7.3e-07 28.3 0.9 1.0 1 0 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KII74984.1 - 0.0045 17.1 1.0 0.0063 16.7 0.3 1.5 2 0 0 2 2 2 1 Multidrug resistance efflux transporter EamA PF00892.15 KII74984.1 - 0.094 12.7 6.3 0.027 14.4 2.4 1.6 2 0 0 2 2 2 0 EamA-like transporter family DEAD_2 PF06733.10 KII74985.1 - 4.7e-13 48.9 0.7 4.7e-13 48.9 0.5 1.9 2 1 0 2 2 2 1 DEAD_2 Evr1_Alr PF04777.8 KII74985.1 - 0.0061 16.4 0.9 0.0061 16.4 0.6 1.9 1 1 1 2 2 2 1 Erv1 / Alr family DEAD PF00270.24 KII74985.1 - 0.008 15.6 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase CLN5 PF15014.1 KII74985.1 - 0.011 15.1 0.2 2.1 7.6 0.1 2.2 2 0 0 2 2 2 0 Ceroid-lipofuscinosis neuronal protein 5 AAA_11 PF13086.1 KII74985.1 - 0.034 13.7 0.2 0.059 12.9 0.1 1.3 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 KII74985.1 - 0.039 13.7 3.1 0.16 11.7 2.2 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DEAD_2 PF06733.10 KII74986.1 - 1.8e-25 89.3 3.5 4.6e-25 88.0 2.4 1.7 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 KII74986.1 - 0.0011 18.9 0.2 0.0037 17.2 0.0 1.9 2 0 0 2 2 2 1 Helicase C-terminal domain SNF2_N PF00176.18 KII74986.1 - 0.015 14.1 0.0 0.027 13.2 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain Zot PF05707.7 KII74986.1 - 0.03 13.7 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) NIF PF03031.13 KII74986.1 - 0.064 12.9 0.2 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase AAA PF00004.24 KII74986.1 - 0.081 13.1 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DDE_Tnp_IS1595 PF12762.2 KII74987.1 - 9e-18 64.5 0.0 1.1e-17 64.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.9 KII74987.1 - 0.0064 15.7 0.0 0.0083 15.3 0.0 1.2 1 0 0 1 1 1 1 Transposase IS66 family ATP_bind_3 PF01171.15 KII74989.1 - 0.035 13.5 0.1 0.04 13.4 0.0 1.2 1 0 0 1 1 1 0 PP-loop family DUF1612 PF07756.7 KII74989.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) ATP-synt_D PF01813.12 KII74994.1 - 0.094 12.2 0.1 22 4.5 0.0 3.2 2 1 1 4 4 4 0 ATP synthase subunit D rve PF00665.21 KII74998.1 - 2.3e-11 43.8 0.0 6.1e-11 42.4 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Kelch_6 PF13964.1 KII75001.1 - 5.3e-18 64.3 6.8 8e-06 25.8 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 KII75001.1 - 8.1e-12 44.7 4.7 0.0016 18.1 0.0 3.2 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KII75001.1 - 3.3e-11 42.8 5.1 0.00023 21.0 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII75001.1 - 1.7e-10 40.2 10.1 0.0045 16.5 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.1 KII75001.1 - 2.6e-10 40.1 4.2 0.051 13.7 0.2 4.0 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KII75001.1 - 8.3e-06 25.3 7.2 0.049 13.4 0.1 3.3 3 1 0 3 3 3 2 Kelch motif FBA_3 PF08268.7 KII75001.1 - 0.1 12.3 0.1 0.19 11.4 0.1 1.5 2 0 0 2 2 2 0 F-box associated domain Kelch_6 PF13964.1 KII75002.1 - 1.3e-06 28.3 6.9 0.052 13.7 0.1 3.9 3 2 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 KII75002.1 - 1.8e-06 27.3 7.6 0.0052 16.2 0.3 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 KII75002.1 - 3.6e-06 26.9 2.6 0.078 13.1 0.0 3.5 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KII75002.1 - 8.2e-05 22.3 12.1 0.095 12.4 0.3 3.6 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KII75002.1 - 0.0016 18.1 4.9 0.093 12.5 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 KII75002.1 - 0.0024 17.7 1.3 0.017 15.0 1.0 2.5 2 1 0 2 2 2 1 Kelch motif SNAP PF14938.1 KII75005.1 - 3.5e-06 26.3 4.1 8.4e-05 21.8 0.1 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP CtIP_N PF10482.4 KII75005.1 - 0.029 14.1 0.4 0.052 13.3 0.3 1.5 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Clathrin PF00637.15 KII75005.1 - 0.039 13.5 1.5 15 5.2 0.1 3.3 2 1 0 3 3 3 0 Region in Clathrin and VPS Virul_Fac PF10139.4 KII75007.1 - 0.087 10.7 0.0 0.1 10.5 0.0 1.0 1 0 0 1 1 1 0 Putative bacterial virulence factor SNAP PF14938.1 KII75008.1 - 1.6e-07 30.7 0.2 1.2e-06 27.8 0.2 1.9 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KII75008.1 - 0.0023 17.8 1.9 0.93 9.4 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat SNAP PF14938.1 KII75009.1 - 4.9e-05 22.6 0.5 7e-05 22.1 0.4 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF2786 PF10979.3 KII75009.1 - 0.061 13.0 0.2 1.3 8.7 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2786) rRNA_proc-arch PF13234.1 KII75009.1 - 0.071 12.2 1.6 0.65 9.1 0.1 2.3 2 0 0 2 2 2 0 rRNA-processing arch domain Mac-1 PF09028.5 KII75010.1 - 0.051 12.3 0.1 0.057 12.1 0.0 1.1 1 0 0 1 1 1 0 Mac 1 UBN2 PF14223.1 KII75012.1 - 0.00014 21.5 0.1 0.00053 19.7 0.0 1.9 1 1 1 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.18 KII75012.1 - 0.0047 16.7 2.2 0.0047 16.7 1.5 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.1 KII75012.1 - 0.0084 15.8 14.7 0.076 12.7 1.0 2.3 1 1 1 2 2 2 2 Zinc knuckle RNA_pol PF00940.14 KII75012.1 - 0.054 11.9 0.0 0.064 11.7 0.0 1.2 1 0 0 1 1 1 0 DNA-dependent RNA polymerase DUF1192 PF06698.6 KII75012.1 - 0.082 12.7 1.9 1.3 8.9 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) zf-CCHC_4 PF14392.1 KII75012.1 - 1 9.0 11.8 1.5 8.5 0.3 2.9 2 0 0 2 2 2 0 Zinc knuckle SNAP PF14938.1 KII75013.1 - 0.00048 19.3 0.2 0.00063 18.9 0.2 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SNAP PF14938.1 KII75014.1 - 0.00054 19.1 0.2 0.00072 18.7 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SNAP PF14938.1 KII75015.1 - 0.056 12.5 0.1 0.078 12.1 0.0 1.2 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP MULE PF10551.4 KII75016.1 - 1.8e-08 34.4 0.0 4.2e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain SNAP PF14938.1 KII75017.1 - 0.00031 20.0 0.1 0.00032 19.9 0.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PLU-1 PF08429.6 KII75017.1 - 0.13 11.1 0.0 0.51 9.1 0.0 1.7 2 0 0 2 2 2 0 PLU-1-like protein RVT_1 PF00078.22 KII75018.1 - 2.7e-23 82.4 0.4 5.6e-23 81.4 0.3 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII75018.1 - 9.4e-21 74.1 0.0 3.1e-20 72.4 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.6 KII75018.1 - 4e-05 23.5 0.0 7.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 KII75018.1 - 9.8e-05 22.7 0.0 0.00024 21.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 KII75018.1 - 0.00054 19.5 0.0 0.0017 17.9 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 KII75018.1 - 0.00064 19.4 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 KII75018.1 - 0.0011 18.8 0.0 0.0037 17.1 0.0 1.9 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF2414 PF10309.4 KII75018.1 - 0.0026 17.4 0.2 0.11 12.1 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2414) RVT_thumb PF06817.9 KII75018.1 - 0.015 14.8 0.2 0.095 12.2 0.1 2.5 3 0 0 3 3 3 0 Reverse transcriptase thumb domain DUF2344 PF10105.4 KII75018.1 - 0.061 12.7 0.7 2 7.8 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2344) Ras PF00071.17 KII75019.1 - 7.8e-56 187.9 0.0 9.1e-56 187.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KII75019.1 - 3.3e-17 63.0 0.0 5.2e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KII75019.1 - 2.2e-10 40.0 0.0 3.8e-10 39.2 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KII75019.1 - 0.00018 21.0 0.1 0.00044 19.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KII75019.1 - 0.00035 19.7 0.0 0.00043 19.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 KII75019.1 - 0.00078 18.7 0.0 0.0026 17.0 0.0 1.7 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit SPATIAL PF15256.1 KII75019.1 - 0.087 12.8 0.4 0.36 10.8 0.2 1.8 1 1 1 2 2 2 0 SPATIAL Rad51 PF08423.6 KII75020.1 - 2.5e-140 465.7 0.2 3e-140 465.4 0.1 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 KII75020.1 - 4.2e-14 52.3 0.0 5.9e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 KII75020.1 - 1.5e-09 37.9 1.8 1.9e-09 37.5 0.4 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain KaiC PF06745.8 KII75020.1 - 6.4e-08 31.9 2.1 1.3e-07 31.0 0.3 2.2 2 1 0 2 2 2 1 KaiC RecA PF00154.16 KII75020.1 - 3.3e-06 26.4 0.3 7.3e-06 25.2 0.2 1.5 1 1 0 1 1 1 1 recA bacterial DNA recombination protein SpoOE-like PF09388.5 KII75020.1 - 0.013 14.9 0.5 1.3 8.6 0.1 2.7 2 1 0 2 2 2 0 Spo0E like sporulation regulatory protein AAA_22 PF13401.1 KII75020.1 - 0.016 15.3 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain PAXNEB PF05625.6 KII75020.1 - 0.042 12.6 0.0 0.2 10.4 0.0 1.9 2 0 0 2 2 2 0 PAXNEB protein ATP-synt_ab PF00006.20 KII75020.1 - 0.071 12.5 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain RVT_1 PF00078.22 KII75021.1 - 1.8e-25 89.5 0.2 7.1e-25 87.6 0.3 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII75021.1 - 1.8e-22 79.7 0.0 3.9e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII75021.1 - 3.9e-08 33.1 0.0 6.5e-07 29.2 0.0 2.4 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII75021.1 - 4.4e-05 23.2 3.2 0.00011 21.8 2.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII75021.1 - 0.00018 21.9 0.1 0.0011 19.4 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease rve_3 PF13683.1 KII75021.1 - 0.0034 16.8 0.1 0.052 13.0 0.0 3.0 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.9 KII75021.1 - 0.017 15.0 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII75021.1 - 0.03 14.1 0.0 0.074 12.8 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII75021.1 - 0.12 12.0 0.1 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease G-patch PF01585.18 KII75022.1 - 1.9e-12 46.7 1.9 2.7e-12 46.2 1.3 1.3 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 KII75022.1 - 0.003 17.3 0.2 0.0044 16.8 0.1 1.4 1 0 0 1 1 1 1 DExH-box splicing factor binding site DUF3975 PF13126.1 KII75024.1 - 0.02 15.0 0.3 0.028 14.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3975) DnaJ PF00226.26 KII75025.1 - 1.7e-27 94.9 6.6 1.9e-27 94.7 3.9 1.6 2 0 0 2 2 2 1 DnaJ domain CTDII PF01556.13 KII75025.1 - 2.7e-18 65.6 1.5 1.3e-15 57.0 0.1 2.3 2 0 0 2 2 2 2 DnaJ C terminal domain Guanylate_kin PF00625.16 KII75027.1 - 4.3e-16 58.8 0.3 5.1e-16 58.6 0.2 1.1 1 0 0 1 1 1 1 Guanylate kinase BK_channel_a PF03493.13 KII75027.1 - 0.036 13.9 0.2 0.076 12.9 0.1 1.6 1 1 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit PDZ PF00595.19 KII75028.1 - 2.4e-11 43.6 0.9 3.5e-11 43.1 0.6 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KII75028.1 - 2.2e-06 27.4 0.2 3.2e-06 26.9 0.2 1.3 1 0 0 1 1 1 1 PDZ domain DUF4165 PF13752.1 KII75028.1 - 0.014 15.1 0.2 10 5.8 0.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4165) ResIII PF04851.10 KII75028.1 - 0.098 12.4 1.6 0.13 12.0 0.9 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit YHS PF04945.8 KII75028.1 - 0.14 12.0 1.5 0.51 10.2 0.7 2.1 2 0 0 2 2 2 0 YHS domain CorA PF01544.13 KII75029.1 - 0.0049 15.9 0.4 0.0063 15.5 0.3 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Borrelia_rep PF03183.8 KII75029.1 - 0.55 10.1 3.2 1 9.2 2.2 1.4 1 0 0 1 1 1 0 Borrelia repeat protein zf-H2C2_2 PF13465.1 KII75030.1 - 3.8e-13 49.0 23.5 6.1e-09 35.7 1.0 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 KII75030.1 - 2.9e-12 46.0 16.1 0.00028 21.0 0.7 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.21 KII75030.1 - 7.7e-12 44.8 23.5 0.00022 21.3 0.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-LYAR PF08790.6 KII75030.1 - 0.0034 17.0 2.6 0.0034 17.0 1.8 2.1 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger LIM PF00412.17 KII75030.1 - 0.47 10.5 11.5 0.63 10.1 1.8 2.9 1 1 2 3 3 3 0 LIM domain SIR2 PF02146.12 KII75030.1 - 1.7 8.3 6.1 4.2 7.0 4.2 1.8 1 1 0 1 1 1 0 Sir2 family zf-met PF12874.2 KII75030.1 - 2 8.7 9.0 3.2 8.0 1.7 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type MMtag PF10159.4 KII75031.1 - 5.1e-23 80.9 0.2 5.1e-23 80.9 0.2 2.0 2 0 0 2 2 2 1 Kinase phosphorylation protein DUF4296 PF14129.1 KII75032.1 - 0.022 14.9 0.1 0.061 13.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) MNE1 PF13762.1 KII75032.1 - 9.6 6.2 10.8 4.9 7.2 5.4 2.1 2 1 0 2 2 2 0 Mitochondrial splicing apparatus component Ldl_recept_a PF00057.13 KII75035.1 - 1.2e-08 34.6 10.1 1.7e-08 34.1 7.0 1.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A SNAP PF14938.1 KII75036.1 - 1.4e-08 34.2 12.8 1.9e-08 33.8 8.9 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP zf-DBF PF07535.7 KII75036.1 - 0.025 14.2 0.2 0.076 12.7 0.1 1.9 1 0 0 1 1 1 0 DBF zinc finger FrhB_FdhB_C PF04432.8 KII75036.1 - 0.096 12.0 1.3 0.16 11.4 0.9 1.2 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus TPR_12 PF13424.1 KII75036.1 - 0.11 12.4 5.7 0.12 12.3 1.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KII75036.1 - 0.17 11.5 10.7 0.11 12.1 2.5 3.1 3 1 1 4 4 4 0 TPR repeat TPR_2 PF07719.12 KII75036.1 - 1.2 9.2 18.8 2.1 8.4 1.8 5.2 4 1 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 KII75036.1 - 4 7.4 9.7 3.2 7.7 0.6 4.0 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain Aha1_N PF09229.6 KII75038.1 - 9.8e-20 70.7 0.4 1.8e-19 69.9 0.3 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 KII75038.1 - 3.7e-17 62.5 0.3 3.6e-16 59.3 0.0 2.2 2 1 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein zf-CCHC PF00098.18 KII75039.1 - 0.0056 16.5 2.8 0.0056 16.5 2.0 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-BED PF02892.10 KII75039.1 - 0.071 12.8 3.0 0.077 12.7 0.1 2.5 3 0 0 3 3 3 0 BED zinc finger DNA_methylase PF00145.12 KII75039.1 - 0.077 12.0 0.3 0.76 8.8 0.1 1.9 1 1 1 2 2 2 0 C-5 cytosine-specific DNA methylase PyrI_C PF02748.10 KII75039.1 - 0.3 10.5 0.0 0.3 10.5 0.0 2.5 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain WD40 PF00400.27 KII75040.1 - 2e-08 33.7 6.8 1.2e-05 24.9 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat Pkinase PF00069.20 KII75041.1 - 1e-52 178.8 0.1 3.8e-52 177.0 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII75041.1 - 1.8e-38 132.1 0.1 4.1e-38 130.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Mitofilin PF09731.4 KII75041.1 - 1.5 7.4 16.9 2 6.9 11.7 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PSDC PF12588.3 KII75042.1 - 0.0034 17.0 0.3 0.0054 16.3 0.0 1.4 2 0 0 2 2 2 1 Phophatidylserine decarboxylase DUF342 PF03961.8 KII75042.1 - 4 5.7 8.5 5 5.4 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) RVT_1 PF00078.22 KII75043.1 - 1.9e-25 89.5 0.2 7.1e-25 87.6 0.3 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII75043.1 - 1.8e-22 79.7 0.0 3.9e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII75043.1 - 4e-08 33.1 0.0 6.5e-07 29.2 0.0 2.4 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII75043.1 - 4.4e-05 23.2 3.2 0.00011 21.8 2.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII75043.1 - 0.00018 21.9 0.1 0.0011 19.4 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease rve_3 PF13683.1 KII75043.1 - 0.0035 16.8 0.1 0.052 13.0 0.0 3.0 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.9 KII75043.1 - 0.017 15.0 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII75043.1 - 0.03 14.1 0.0 0.075 12.8 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 KII75043.1 - 0.12 11.9 0.1 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Pkinase PF00069.20 KII75044.1 - 4.3e-36 124.4 0.0 4.3e-36 124.4 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII75044.1 - 3.9e-26 91.6 2.8 1.5e-25 89.7 0.0 2.6 2 1 1 3 3 3 1 Protein tyrosine kinase APH PF01636.18 KII75044.1 - 0.098 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Gemin6 PF06372.7 KII75045.1 - 0.4 9.9 3.4 0.61 9.4 2.2 1.4 1 1 0 1 1 1 0 Gemin6 protein Orthopox_B11R PF07033.6 KII75045.1 - 6.7 6.2 8.0 11 5.5 1.2 2.6 2 1 0 2 2 2 0 Orthopoxvirus B11R protein P22_Tail-4 PF11650.3 KII75046.1 - 0.052 13.0 0.0 0.082 12.4 0.0 1.2 1 0 0 1 1 1 0 P22 tail accessory factor DUF507 PF04368.8 KII75047.1 - 0.14 11.7 4.0 1.4 8.5 2.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF507) TcpF PF06340.6 KII75048.1 - 0.03 13.4 0.0 0.037 13.1 0.0 1.1 1 0 0 1 1 1 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F Serpin PF00079.15 KII75049.1 - 9.9e-46 156.5 5.3 1.1e-45 156.3 3.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Integrin_beta PF00362.13 KII75051.1 - 5.5e-11 42.0 0.1 7.5e-11 41.5 0.1 1.1 1 0 0 1 1 1 1 Integrin, beta chain E1_DerP2_DerF2 PF02221.10 KII75053.1 - 3.6e-11 43.4 0.5 4.4e-11 43.1 0.3 1.1 1 0 0 1 1 1 1 ML domain RGS PF00615.14 KII75056.1 - 3.5e-15 56.1 1.1 6.6e-15 55.2 0.7 1.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain MFS_1 PF07690.11 KII75057.1 - 2.2e-35 122.0 29.6 1.4e-33 116.0 18.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KII75057.1 - 2.9e-09 36.0 5.9 2.9e-09 36.0 4.1 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter DUF1469 PF07332.6 KII75057.1 - 0.039 13.6 0.1 0.25 11.0 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1469) OTU PF02338.14 KII75058.1 - 2.9e-20 73.0 1.3 4e-20 72.6 0.2 1.7 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 KII75058.1 - 2.6e-05 23.6 1.7 0.046 13.0 0.1 2.4 1 1 1 2 2 2 2 Peptidase C65 Otubain SAM_1 PF00536.25 KII75060.1 - 2.4e-19 69.2 0.8 4.9e-12 45.8 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.18 KII75060.1 - 2.7e-13 50.1 1.8 9.6e-13 48.3 0.5 2.3 2 1 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) SAM_2 PF07647.12 KII75060.1 - 3.2e-11 42.9 0.9 1.5e-05 24.7 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) NCD1 PF04904.8 KII75060.1 - 0.00026 20.6 0.1 0.26 11.0 0.1 2.5 2 0 0 2 2 2 2 NAB conserved region 1 (NCD1) Ribosomal_S5_C PF03719.10 KII75061.1 - 2.8e-22 77.7 0.3 5e-22 76.9 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 KII75061.1 - 2.8e-22 78.2 1.1 6.4e-22 77.0 0.8 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain KH_1 PF00013.24 KII75062.1 - 6.4e-19 67.3 0.0 2.6e-10 39.7 0.0 4.0 4 0 0 4 4 4 3 KH domain KH_3 PF13014.1 KII75062.1 - 5.6e-10 38.6 0.0 2.1e-07 30.4 0.0 2.7 2 0 0 2 2 2 2 KH domain Secretin_N PF03958.12 KII75062.1 - 0.012 15.7 0.0 9.5 6.4 0.0 2.6 2 0 0 2 2 2 0 Bacterial type II/III secretion system short domain DDE_3 PF13358.1 KII75063.1 - 0.00011 22.0 0.4 0.00011 21.9 0.2 1.2 1 1 0 1 1 1 1 DDE superfamily endonuclease Phe_ZIP PF08916.6 KII75063.1 - 0.079 13.2 3.2 0.092 13.0 1.3 1.8 2 0 0 2 2 2 0 Phenylalanine zipper Antimicrobial19 PF08225.6 KII75063.1 - 0.27 10.6 1.8 3.6 7.0 0.7 2.3 2 0 0 2 2 2 0 Pseudin antimicrobial peptide PilS PF08805.6 KII75064.1 - 0.00059 19.3 0.3 0.00088 18.7 0.2 1.4 1 0 0 1 1 1 1 PilS N terminal DUF2996 PF11210.3 KII75064.1 - 0.081 13.1 0.9 0.87 9.8 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2996) Serpin PF00079.15 KII75066.1 - 6.1e-55 186.8 4.9 7.3e-55 186.5 3.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII75067.1 - 3.2e-46 158.1 6.1 7.2e-46 156.9 4.2 1.5 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) BK_channel_a PF03493.13 KII75067.1 - 0.016 15.1 0.2 0.043 13.7 0.1 1.7 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit Serpin PF00079.15 KII75068.1 - 1.6e-56 192.0 1.0 1.9e-56 191.8 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) TetR_C_2 PF08361.6 KII75068.1 - 0.058 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 MAATS-type transcriptional repressor, C-terminal region Serpin PF00079.15 KII75069.1 - 9.9e-53 179.5 0.1 1.1e-52 179.4 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII75070.1 - 4.5e-35 121.4 0.4 5.3e-35 121.2 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.15 KII75071.1 - 3.8e-56 190.8 2.2 4.2e-56 190.6 1.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Gemini_mov PF01708.11 KII75072.1 - 0.087 12.3 0.1 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Geminivirus putative movement protein DUF2809 PF10990.3 KII75073.1 - 0.06 13.7 0.6 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2809) Macoilin PF09726.4 KII75073.1 - 0.1 10.8 12.9 0.13 10.4 8.9 1.0 1 0 0 1 1 1 0 Transmembrane protein PRP21_like_P PF12230.3 KII75073.1 - 0.54 9.7 5.4 0.72 9.3 3.7 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein Med5 PF08689.5 KII75073.1 - 1.8 6.1 4.6 2 6.0 3.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit Med5 UPF0233 PF06781.7 KII75074.1 - 0.085 12.4 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0233) DUF4064 PF13273.1 KII75077.1 - 0.0027 17.7 1.3 0.0035 17.4 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) zf-LITAF-like PF10601.4 KII75077.1 - 0.0035 17.1 0.7 1.7 8.5 0.0 2.2 2 0 0 2 2 2 2 LITAF-like zinc ribbon domain VirB8 PF04335.8 KII75077.1 - 0.0036 16.9 2.2 0.045 13.3 0.5 2.0 1 1 1 2 2 2 1 VirB8 protein TMEM154 PF15102.1 KII75077.1 - 0.013 15.1 0.9 0.017 14.8 0.6 1.2 1 0 0 1 1 1 0 TMEM154 protein family Wzz PF02706.10 KII75077.1 - 0.068 12.9 0.7 0.068 12.9 0.5 1.6 2 0 0 2 2 2 0 Chain length determinant protein IncA PF04156.9 KII75077.1 - 0.64 9.5 4.4 0.4 10.2 1.8 1.6 2 0 0 2 2 2 0 IncA protein DUF3377 PF11857.3 KII75077.1 - 1.1 8.9 4.8 0.14 11.7 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) OapA_N PF08525.6 KII75077.1 - 4.3 7.2 5.6 9.9 6.0 3.9 1.6 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif DUF4448 PF14610.1 KII75078.1 - 0.00012 21.6 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF1191 PF06697.7 KII75078.1 - 0.00013 20.8 0.1 0.00016 20.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) DUF912 PF06024.7 KII75078.1 - 0.0048 16.9 0.0 0.0076 16.2 0.0 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) LRR19-TM PF15176.1 KII75078.1 - 0.0093 15.6 0.2 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain TMEM154 PF15102.1 KII75078.1 - 0.014 15.1 0.6 0.018 14.7 0.4 1.2 1 0 0 1 1 1 0 TMEM154 protein family Herpes_gE PF02480.11 KII75078.1 - 0.02 13.1 0.3 0.023 12.9 0.2 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E STE2 PF02116.10 KII75078.1 - 0.021 13.8 0.0 0.026 13.5 0.0 1.1 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR SKG6 PF08693.5 KII75078.1 - 0.022 14.0 0.7 0.022 14.0 0.5 2.3 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF2370 PF10176.4 KII75078.1 - 0.022 14.1 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF3377 PF11857.3 KII75078.1 - 0.035 13.7 0.0 0.035 13.7 0.0 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF3377) CCSMST1 PF15013.1 KII75078.1 - 0.053 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 CCSMST1 family Calcyon PF06387.6 KII75078.1 - 0.062 12.6 0.0 0.065 12.5 0.0 1.1 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) DUF4064 PF13273.1 KII75078.1 - 0.096 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) CbtB PF09489.5 KII75078.1 - 0.12 12.3 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) DUF1180 PF06679.7 KII75078.1 - 0.25 11.2 4.6 0.38 10.6 3.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) gpUL132 PF11359.3 KII75078.1 - 1.2 8.4 7.4 1.8 7.8 5.1 1.2 1 0 0 1 1 1 0 Glycoprotein UL132 Fig1 PF12351.3 KII75082.1 - 0.08 12.8 0.4 0.095 12.5 0.3 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 PHD_3 PF13922.1 KII75082.1 - 0.18 12.1 3.5 0.26 11.5 2.4 1.3 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx OPT PF03169.10 KII75083.1 - 0.025 13.0 0.0 0.03 12.7 0.0 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein CCDC71L PF15374.1 KII75084.1 - 0.027 13.8 0.6 0.029 13.6 0.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L rve PF00665.21 KII75087.1 - 0.008 16.2 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Dirigent PF03018.9 KII75088.1 - 0.13 11.8 0.0 1.1 8.7 0.0 2.0 1 1 0 1 1 1 0 Dirigent-like protein Rad21_Rec8 PF04824.11 KII75088.1 - 0.17 11.1 0.4 0.61 9.3 0.1 2.1 2 0 0 2 2 2 0 Conserved region of Rad21 / Rec8 like protein FMN_bind_2 PF04299.7 KII75089.1 - 2.3e-47 160.5 0.0 2.9e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain Pyridox_ox_2 PF12900.2 KII75089.1 - 0.098 12.4 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase FAM124 PF15067.1 KII75089.1 - 0.14 11.5 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 FAM124 family KAT11 PF08214.6 KII75090.1 - 0.016 14.2 1.5 0.018 14.1 1.0 1.5 1 1 0 1 1 1 0 Histone acetylation protein FYRC PF05965.9 KII75091.1 - 0.064 13.0 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 F/Y rich C-terminus Thermopsin PF05317.6 KII75092.1 - 0.36 9.6 8.8 0.51 9.2 6.1 1.2 1 0 0 1 1 1 0 Thermopsin Ogr_Delta PF04606.7 KII75095.1 - 6.4e-18 64.1 1.4 9.7e-18 63.5 0.9 1.3 1 0 0 1 1 1 1 Ogr/Delta-like zinc finger Phage_portal PF04860.7 KII75095.1 - 1.1e-12 47.2 0.0 1.4e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Phage portal protein Elf1 PF05129.8 KII75095.1 - 0.073 12.7 0.4 0.12 12.1 0.3 1.2 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like TFIIS_C PF01096.13 KII75095.1 - 3.3 7.4 6.4 20 4.9 4.5 1.9 1 1 1 2 2 2 0 Transcription factor S-II (TFIIS) DUF1768 PF08719.6 KII75096.1 - 6.4e-22 77.9 0.0 7.4e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) APG12 PF04110.8 KII75097.1 - 0.057 13.6 0.4 0.6 10.3 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 NA37 PF04245.8 KII75098.1 - 3.6e-23 82.4 3.3 5.3e-23 81.8 2.3 1.2 1 0 0 1 1 1 1 37-kD nucleoid-associated bacterial protein DDE_3 PF13358.1 KII75101.1 - 0.0093 15.7 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease IncA PF04156.9 KII75102.1 - 0.015 14.9 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 IncA protein DUF4097 PF13349.1 KII75102.1 - 0.22 11.0 3.5 4.3 6.8 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4097) Virul_fac_BrkB PF03631.10 KII75103.1 - 0.041 13.2 0.7 0.051 12.9 0.1 1.4 1 1 0 1 1 1 0 Virulence factor BrkB DUF2214 PF09980.4 KII75104.1 - 0.056 13.1 0.2 0.096 12.4 0.1 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2214) TFIID-31kDa PF02291.10 KII75106.1 - 3e-12 46.4 0.2 4.4e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Gal-3-0_sulfotr PF06990.6 KII75107.1 - 4.3e-27 94.8 1.3 2.1e-26 92.5 0.9 1.8 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase HTH_29 PF13551.1 KII75108.1 - 3.2e-10 40.1 0.0 4e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KII75108.1 - 1.1e-05 24.9 0.0 2.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.10 KII75108.1 - 4e-05 23.3 0.0 7.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_32 PF13565.1 KII75108.1 - 0.00075 20.2 0.0 0.0013 19.5 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 KII75108.1 - 0.00085 19.2 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.13 KII75108.1 - 0.04 13.6 0.1 0.07 12.8 0.0 1.4 1 1 1 2 2 2 0 'Paired box' domain DDE_3 PF13358.1 KII75109.1 - 2e-10 40.5 0.0 2.2e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF544 PF04424.8 KII75110.1 - 3.6e-20 71.9 0.1 5.7e-20 71.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF544) NDUF_B6 PF09782.4 KII75112.1 - 0.077 12.8 0.1 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Glyco_transf_7N PF13733.1 KII75113.1 - 1e-32 112.3 0.2 1.2e-32 112.1 0.1 1.1 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Orbi_NS3 PF01616.11 KII75114.1 - 0.081 11.8 0.3 0.11 11.4 0.2 1.1 1 0 0 1 1 1 0 Orbivirus NS3 DDE_Tnp_IS1595 PF12762.2 KII75115.1 - 1.6e-09 37.7 0.0 2.5e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain IGR PF09597.5 KII75116.1 - 0.013 15.3 0.9 0.024 14.5 0.6 1.4 1 0 0 1 1 1 0 IGR protein motif FPL PF09758.4 KII75117.1 - 0.0063 16.2 0.2 0.0084 15.8 0.1 1.4 1 1 0 1 1 1 1 Uncharacterised conserved protein Oxidored_q1_C PF01010.14 KII75118.1 - 0.0088 15.5 0.1 0.0095 15.4 0.1 1.1 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus rve PF00665.21 KII75119.1 - 6.7e-25 87.5 0.0 2e-24 85.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.1 KII75119.1 - 0.037 13.5 0.0 0.092 12.2 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain FLYWCH PF04500.11 KII75120.1 - 0.00013 21.7 3.0 0.00025 20.8 2.1 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain Linker_histone PF00538.14 KII75121.1 - 1.9e-23 82.3 0.7 1.9e-23 82.3 0.5 2.1 2 1 0 2 2 2 1 linker histone H1 and H5 family HTH_32 PF13565.1 KII75121.1 - 0.62 10.9 0.1 0.62 10.9 0.0 2.4 2 1 0 2 2 2 0 Homeodomain-like domain Mitofilin PF09731.4 KII75121.1 - 1.6 7.2 27.7 2 6.9 19.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DDE_3 PF13358.1 KII75122.1 - 1.1e-17 64.1 0.0 1.1e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 KII75122.1 - 0.031 14.3 0.0 0.043 13.9 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain ESCRT-II PF05871.7 KII75123.1 - 0.031 14.1 0.0 0.038 13.9 0.0 1.3 1 1 0 1 1 1 0 ESCRT-II complex subunit DUF2321 PF10083.4 KII75124.1 - 0.011 15.2 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) RhoGEF PF00621.15 KII75125.1 - 3.7e-23 82.3 3.0 5.8e-23 81.6 2.1 1.3 1 0 0 1 1 1 1 RhoGEF domain Kin17_mid PF10357.4 KII75126.1 - 1.8e-37 127.8 1.5 2.5e-37 127.3 1.1 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 KII75126.1 - 0.0016 18.5 7.1 0.0016 18.5 4.9 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KII75126.1 - 0.056 13.6 5.2 0.056 13.6 3.6 2.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF3279 PF11682.3 KII75126.1 - 0.38 10.3 4.8 0.31 10.6 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3279) zf-C2H2_2 PF12756.2 KII75126.1 - 0.41 10.7 7.0 0.45 10.6 1.7 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 KII75126.1 - 4.6 7.8 5.9 4.5 7.8 2.8 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger DUF4375 PF14300.1 KII75127.1 - 1.5 8.7 5.1 5.8 6.9 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4375) INCENP_ARK-bind PF03941.10 KII75129.1 - 4.4e-11 42.4 1.7 1.2e-10 41.0 1.2 1.8 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region Tup_N PF08581.5 KII75130.1 - 8.1e-05 22.7 7.6 8.1e-05 22.7 5.2 1.8 2 0 0 2 2 2 1 Tup N-terminal DUF1043 PF06295.7 KII75130.1 - 0.0019 17.8 6.2 0.0019 17.8 4.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1043) Trep_dent_lipo PF09710.5 KII75130.1 - 0.017 13.8 9.7 0.02 13.5 6.7 1.0 1 0 0 1 1 1 0 Treponema clustered lipoprotein (Trep_dent_lipo) YbjQ_1 PF01906.12 KII75130.1 - 0.087 13.2 0.2 0.15 12.5 0.2 1.5 1 0 0 1 1 1 0 Putative heavy-metal-binding eIF-4B PF06273.6 KII75130.1 - 0.11 11.2 4.4 0.13 11.0 3.1 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B AAT PF03417.11 KII75130.1 - 0.25 10.7 2.4 0.19 11.1 0.9 1.4 1 1 1 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase SpoU_sub_bind PF08032.7 KII75130.1 - 0.98 9.6 3.3 5.4 7.2 0.1 2.3 2 1 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Mt_ATP-synt_B PF05405.9 KII75130.1 - 1.6 8.1 13.2 0.38 10.2 3.4 2.0 1 1 1 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SYCE1 PF15233.1 KII75130.1 - 1.7 8.5 12.5 2.7 7.9 8.7 1.3 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 DUF342 PF03961.8 KII75130.1 - 2.8 6.2 9.1 2.9 6.1 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.10 KII75130.1 - 3.9 6.5 10.0 4.4 6.4 7.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med28 PF11594.3 KII75130.1 - 4.1 7.6 8.3 2.5 8.4 4.1 1.8 1 1 1 2 2 2 0 Mediator complex subunit 28 DUF244 PF03112.9 KII75130.1 - 7 6.1 11.3 2.7 7.5 2.4 2.1 1 1 1 2 2 2 0 Uncharacterized protein family (ORF7) DUF DDE_3 PF13358.1 KII75131.1 - 2.3e-14 53.3 0.0 3.5e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease TetR_C_8 PF14278.1 KII75133.1 - 0.061 13.7 4.0 0.71 10.2 0.2 3.2 2 1 1 3 3 3 0 Transcriptional regulator C-terminal region OrfB_Zn_ribbon PF07282.6 KII75134.1 - 0.033 13.8 0.0 0.07 12.7 0.0 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain RVT_1 PF00078.22 KII75136.1 - 5.1e-08 32.5 0.1 1.1e-07 31.4 0.1 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Yip1 PF04893.12 KII75137.1 - 6.5e-07 29.0 15.7 6.5e-07 29.0 10.9 1.3 1 1 0 1 1 1 1 Yip1 domain DUF3392 PF11872.3 KII75137.1 - 0.03 14.2 2.4 0.085 12.8 1.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3392) Phtf-FEM1B_bdg PF12129.3 KII75137.1 - 0.037 13.3 0.3 0.079 12.3 0.2 1.6 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor Ribosom_S12_S23 PF00164.20 KII75139.1 - 1.4e-41 140.7 1.9 1.7e-41 140.4 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DDE_Tnp_IS1595 PF12762.2 KII75140.1 - 0.0013 18.6 0.0 0.0018 18.1 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain ATP12 PF07542.6 KII75141.1 - 2.6e-10 40.3 0.1 3.2e-10 40.0 0.1 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Adeno_E3_CR2 PF02439.10 KII75142.1 - 0.0079 15.7 1.9 0.014 14.9 1.3 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 DUF912 PF06024.7 KII75142.1 - 0.14 12.2 0.4 0.19 11.8 0.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PIG-P PF08510.7 KII75142.1 - 0.14 11.8 1.4 0.2 11.3 1.0 1.2 1 0 0 1 1 1 0 PIG-P DUF3149 PF11346.3 KII75142.1 - 0.15 11.6 0.7 0.25 10.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) TMEM154 PF15102.1 KII75142.1 - 1.1 8.9 4.0 4.6 6.9 2.8 1.8 1 1 0 1 1 1 0 TMEM154 protein family Ceramidase PF05875.7 KII75143.1 - 4.3e-20 71.9 0.7 7.4e-20 71.1 0.5 1.3 1 0 0 1 1 1 1 Ceramidase DDE_3 PF13358.1 KII75143.1 - 1.6e-11 44.1 0.1 8.3e-07 28.8 0.2 3.3 1 1 1 2 2 2 2 DDE superfamily endonuclease zf-CCHC_3 PF13917.1 KII75144.1 - 1.4e-15 56.7 8.5 2.8e-15 55.7 5.9 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.18 KII75144.1 - 0.0083 16.0 3.0 0.013 15.4 2.1 1.3 1 0 0 1 1 1 1 Zinc knuckle RP-C_C PF11800.3 KII75144.1 - 0.11 12.1 1.4 0.16 11.6 1.0 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region NYD-SP28 PF14772.1 KII75144.1 - 5.3 7.1 7.8 3.1 7.9 1.6 2.7 2 1 1 3 3 3 0 Sperm tail DUF4521 PF15021.1 KII75145.1 - 0.015 14.9 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4521) Cytochrom_C PF00034.16 KII75146.1 - 6.6e-09 36.4 0.0 1.2e-08 35.6 0.0 1.4 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 KII75146.1 - 1.7e-06 28.0 0.6 5.7e-06 26.3 0.4 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 KII75146.1 - 0.0036 16.7 0.5 0.014 14.8 0.3 2.0 1 1 0 1 1 1 1 Cytochrome c-550 domain Cytochrom_C1 PF02167.10 KII75146.1 - 0.041 13.5 0.2 0.099 12.2 0.1 1.8 1 1 1 2 2 2 0 Cytochrome C1 family Filament PF00038.16 KII75147.1 - 0.011 15.2 8.0 0.014 14.9 5.5 1.3 1 0 0 1 1 1 0 Intermediate filament protein Mating_N PF12731.2 KII75147.1 - 0.04 13.7 0.1 0.087 12.7 0.1 1.6 1 0 0 1 1 1 0 Mating-type protein beta 1 LXG PF04740.7 KII75147.1 - 0.046 13.4 10.6 0.75 9.5 4.9 2.4 1 1 0 2 2 2 0 LXG domain of WXG superfamily Phe_tRNA-synt_N PF02912.13 KII75147.1 - 0.049 13.3 1.0 0.049 13.3 0.7 2.5 3 0 0 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain Apolipoprotein PF01442.13 KII75147.1 - 0.049 13.1 2.3 0.11 11.9 1.6 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Mod_r PF07200.8 KII75147.1 - 0.11 12.4 14.7 0.37 10.7 6.4 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF948 PF06103.6 KII75147.1 - 0.11 12.3 3.5 4.9 7.0 1.1 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Peptidase_M32 PF02074.10 KII75147.1 - 0.12 11.0 3.8 0.12 10.9 2.1 1.4 1 1 1 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase DUF883 PF05957.8 KII75147.1 - 0.17 12.3 1.4 0.99 9.8 0.2 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) ING PF12998.2 KII75147.1 - 0.19 12.0 12.4 0.22 11.8 8.1 1.5 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding ATP-synt_B PF00430.13 KII75147.1 - 0.25 11.1 11.0 0.2 11.4 2.8 2.3 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Colicin PF01024.14 KII75147.1 - 0.56 9.7 5.7 0.64 9.5 3.3 1.4 1 1 0 1 1 1 0 Colicin pore forming domain Tweety PF04906.8 KII75147.1 - 0.62 8.4 3.6 1.2 7.4 0.9 1.9 1 1 1 2 2 2 0 Tweety YtxH PF12732.2 KII75147.1 - 0.68 10.3 9.5 0.11 12.9 0.8 2.5 2 1 1 3 3 3 0 YtxH-like protein ISG65-75 PF11727.3 KII75147.1 - 0.85 8.6 10.1 0.5 9.3 2.7 2.0 1 1 1 2 2 2 0 Invariant surface glycoprotein Erf4 PF10256.4 KII75147.1 - 0.98 9.3 5.8 7.2 6.5 0.1 3.1 2 1 1 3 3 3 0 Golgin subfamily A member 7/ERF4 family V_ATPase_I PF01496.14 KII75147.1 - 3.5 5.3 8.6 4.3 5.0 5.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HSCB_C PF07743.8 KII75147.1 - 3.9 7.9 11.3 6.6 7.2 4.2 2.9 1 1 2 3 3 3 0 HSCB C-terminal oligomerisation domain DUF4110 PF13422.1 KII75147.1 - 7.6 6.4 7.6 32 4.4 5.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4110) DUF1797 PF08796.5 KII75148.1 - 0.095 12.5 0.1 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1797) Pkinase PF00069.20 KII75149.1 - 1.8e-64 217.3 0.1 2.2e-64 217.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KII75149.1 - 8e-35 120.1 0.1 1e-34 119.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.6 KII75149.1 - 0.0014 17.5 0.0 0.0026 16.6 0.0 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.1 KII75149.1 - 0.0014 17.6 0.0 0.0058 15.6 0.0 2.0 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.17 KII75149.1 - 0.11 11.8 0.7 0.3 10.3 0.1 1.9 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.9 KII75149.1 - 0.15 11.1 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DDE_3 PF13358.1 KII75150.1 - 6.5e-14 51.9 0.0 1.4e-13 50.8 0.0 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.1 KII75150.1 - 1.8e-05 24.2 0.0 3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 KII75150.1 - 0.013 15.5 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Transposase DDE_Tnp_ISAZ013 PF07592.6 KII75150.1 - 0.018 13.7 0.0 0.46 9.1 0.0 2.1 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain DUF3361 PF11841.3 KII75151.1 - 0.027 14.1 0.2 0.039 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) F_actin_bind PF08919.5 KII75151.1 - 0.12 12.0 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 F-actin binding zf-UBR PF02207.15 KII75152.1 - 1.1e-06 28.2 11.9 3.3e-06 26.7 8.3 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Bul1_N PF04425.7 KII75155.1 - 0.046 12.2 0.0 0.06 11.8 0.0 1.1 1 0 0 1 1 1 0 Bul1 N terminus COX16 PF14138.1 KII75156.1 - 0.045 13.9 1.1 0.14 12.3 0.8 1.9 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 DUF3519 PF12033.3 KII75156.1 - 2 8.6 6.9 0.27 11.4 1.3 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3519) HHH_8 PF14716.1 KII75156.1 - 4.5 7.5 6.3 0.45 10.7 0.8 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix domain DDE_3 PF13358.1 KII75158.1 - 0.13 12.0 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF4327 PF14217.1 KII75159.1 - 0.13 12.1 0.0 0.38 10.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4327) rve PF00665.21 KII75160.1 - 1.1e-05 25.5 0.0 4.4e-05 23.5 0.0 1.8 1 1 1 2 2 2 1 Integrase core domain Glyco_hydro_cc PF11790.3 KII75160.1 - 0.039 13.3 0.1 0.041 13.3 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase catalytic core Retrotrans_gag PF03732.12 KII75161.1 - 3.1e-05 23.9 0.6 9.6e-05 22.3 0.2 1.9 1 1 1 2 2 2 1 Retrotransposon gag protein UBN2 PF14223.1 KII75161.1 - 0.2 11.4 2.2 2.4 7.9 0.1 2.2 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type BNR PF02012.15 KII75163.1 - 3.5e-06 26.0 5.2 0.16 11.8 0.1 4.1 4 0 0 4 4 4 3 BNR/Asp-box repeat zf-RING-like PF08746.6 KII75163.1 - 0.12 12.3 1.5 0.28 11.2 0.3 2.2 2 0 0 2 2 2 0 RING-like domain Ldl_recept_a PF00057.13 KII75164.1 - 1.1e-09 37.9 7.9 1.1e-09 37.9 5.5 1.8 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.13 KII75165.1 - 3.3e-07 30.0 10.2 3.3e-07 30.0 7.1 2.5 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII75165.1 - 0.031 14.0 1.8 6.8 6.9 0.0 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat NDUF_B6 PF09782.4 KII75165.1 - 0.049 13.4 0.1 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit BNR_2 PF13088.1 KII75165.1 - 0.14 11.4 0.0 0.7 9.1 0.0 1.9 1 1 0 1 1 1 0 BNR repeat-like domain rve PF00665.21 KII75169.1 - 5.6e-29 100.6 0.2 1.6e-28 99.2 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.22 KII75169.1 - 1.2e-24 86.8 0.1 2.3e-24 85.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.15 KII75169.1 - 1.3e-05 24.9 0.0 3.7e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.1 KII75169.1 - 2.3e-05 23.8 0.2 0.00023 20.6 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain gag-asp_proteas PF13975.1 KII75169.1 - 3.2e-05 23.6 0.0 6.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KII75169.1 - 0.00013 22.3 0.0 0.00056 20.3 0.0 2.1 2 0 0 2 2 2 1 Aspartyl protease zf-H2C2 PF09337.5 KII75169.1 - 0.00019 20.7 0.9 0.00059 19.1 0.6 1.9 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Asp_protease PF09668.5 KII75169.1 - 0.014 14.9 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease DUF4070 PF13282.1 KII75169.1 - 0.041 13.4 0.0 0.87 9.1 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4070) CotJB PF12652.2 KII75169.1 - 0.091 12.8 0.8 5.1 7.2 0.0 2.8 2 0 0 2 2 2 0 CotJB protein RVP_2 PF08284.6 KII75169.1 - 0.096 12.6 0.1 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_3 PF13917.1 KII75169.1 - 2.3 8.0 9.7 5.1 6.9 0.8 2.6 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.1 KII75169.1 - 4.2 7.1 8.4 11 5.8 0.5 2.8 2 0 0 2 2 2 0 Zinc knuckle SNAP PF14938.1 KII75170.1 - 2e-07 30.4 1.5 2.5e-07 30.1 1.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR PF01535.15 KII75170.1 - 0.02 14.8 0.6 0.26 11.3 0.0 2.8 3 0 0 3 3 3 0 PPR repeat TPR_12 PF13424.1 KII75170.1 - 0.044 13.7 0.6 0.52 10.2 0.1 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4363 PF14276.1 KII75170.1 - 0.14 11.9 2.7 0.62 9.7 0.0 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF4363) Ldl_recept_a PF00057.13 KII75171.1 - 1e-31 108.5 107.7 2e-11 43.5 2.7 6.4 6 0 0 6 6 6 6 Low-density lipoprotein receptor domain class A DUF1948 PF09185.5 KII75171.1 - 0.11 12.2 0.8 0.49 10.0 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1948) rve PF00665.21 KII75172.1 - 6e-05 23.1 0.0 0.00017 21.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF1758 PF05585.7 KII75172.1 - 0.00051 19.6 1.5 0.016 14.7 1.0 2.5 1 1 0 1 1 1 1 Putative peptidase (DUF1758) RVT_1 PF00078.22 KII75172.1 - 0.0035 16.7 0.1 0.0074 15.6 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.1 KII75172.1 - 0.033 14.6 0.0 0.076 13.5 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease RVT_1 PF00078.22 KII75173.1 - 4.4e-10 39.2 0.1 9.5e-10 38.1 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L32e PF01655.13 KII75175.1 - 4.6e-43 145.7 1.7 5.5e-43 145.4 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 EFG_IV PF03764.13 KII75176.1 - 1.2e-34 118.4 0.0 3.6e-34 116.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 KII75176.1 - 6.4e-18 64.4 0.0 1.4e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 KII75176.1 - 3e-15 55.8 0.0 5.9e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 KII75176.1 - 1.8e-06 27.9 0.0 4.1e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RVT_1 PF00078.22 KII75178.1 - 2.3e-25 89.2 0.2 8.5e-25 87.3 0.3 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KII75178.1 - 2.2e-22 79.4 0.0 4.7e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.15 KII75178.1 - 5.3e-08 32.6 0.0 7.7e-07 28.9 0.0 2.4 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.18 KII75178.1 - 4.8e-05 23.0 3.2 0.00013 21.6 2.2 1.8 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 KII75178.1 - 0.00024 21.5 0.1 0.0013 19.2 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease rve_3 PF13683.1 KII75178.1 - 0.0049 16.3 0.1 0.06 12.8 0.0 2.8 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.9 KII75178.1 - 0.019 14.8 0.0 0.051 13.5 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.1 KII75178.1 - 0.036 13.8 0.0 0.087 12.6 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 KII75180.1 - 0.1 12.5 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Retroviral aspartyl protease Baculo_p24 PF05073.7 KII75181.1 - 0.061 12.8 0.1 0.07 12.6 0.0 1.1 1 0 0 1 1 1 0 Baculovirus P24 capsid protein RE_AlwI PF09491.5 KII75182.1 - 0.077 11.4 1.1 0.079 11.4 0.7 1.1 1 0 0 1 1 1 0 AlwI restriction endonuclease VirArc_Nuclease PF12187.3 KII75183.1 - 0.11 11.9 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Viral/Archaeal nuclease YopH_N PF09013.5 KII75185.1 - 0.047 13.3 1.0 0.16 11.6 0.0 2.4 3 0 0 3 3 3 0 YopH, N-terminal DDE_3 PF13358.1 KII75186.1 - 6.6e-09 35.6 0.0 1.2e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Baculo_p48 PF04878.8 KII75186.1 - 0.04 12.8 0.2 0.052 12.4 0.1 1.2 1 0 0 1 1 1 0 Baculovirus P48 protein Ofd1_CTDD PF10637.4 KII75186.1 - 0.085 11.9 0.1 1 8.4 0.0 1.9 1 1 1 2 2 2 0 Oxoglutarate and iron-dependent oxygenase degradation C-term RVT_1 PF00078.22 KII75187.1 - 0.0011 18.3 0.0 0.0013 18.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RE_NgoPII PF09521.5 KII75192.1 - 0.041 12.6 0.0 0.081 11.6 0.0 1.5 2 0 0 2 2 2 0 NgoPII restriction endonuclease DUF1072 PF06380.6 KII75195.1 - 1.7 8.3 4.2 4.1 7.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) Rhodopsin_N PF10413.4 KII75197.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Amino terminal of the G-protein receptor rhodopsin FAM60A PF15396.1 KII75199.1 - 5.6e-08 32.7 0.1 8.4e-08 32.2 0.1 1.3 1 0 0 1 1 1 1 Protein Family FAM60A Med14 PF08638.6 KII75201.1 - 7.7e-13 48.1 0.1 1.6e-12 47.1 0.1 1.5 1 0 0 1 1 1 1 Mediator complex subunit MED14 TFIIS_C PF01096.13 KII75203.1 - 2e-14 52.9 3.8 2e-14 52.9 2.6 3.0 4 0 0 4 4 3 1 Transcription factor S-II (TFIIS) DZR PF12773.2 KII75203.1 - 8.8e-06 25.4 9.0 0.0019 17.9 1.6 2.3 2 0 0 2 2 2 2 Double zinc ribbon A2L_zn_ribbon PF08792.5 KII75203.1 - 0.00026 20.3 13.3 0.6 9.6 2.2 3.5 3 0 0 3 3 3 3 A2L zinc ribbon domain zf-ribbon_3 PF13248.1 KII75203.1 - 0.0029 16.7 13.9 1.1 8.5 0.0 4.0 4 0 0 4 4 4 2 zinc-ribbon domain C1_1 PF00130.17 KII75203.1 - 0.011 15.4 2.7 0.011 15.4 1.9 3.0 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rpr2 PF04032.11 KII75203.1 - 0.027 14.3 1.0 0.027 14.3 0.7 2.9 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn_Tnp_IS1595 PF12760.2 KII75203.1 - 0.039 13.7 6.0 0.4 10.5 0.3 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DUF3236 PF11576.3 KII75203.1 - 0.087 12.2 0.0 0.18 11.1 0.0 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3236) Baculo_LEF5_C PF11792.3 KII75203.1 - 0.11 11.9 0.0 0.11 11.9 0.0 3.2 4 1 1 5 5 4 0 Baculoviridae late expression factor 5 C-terminal domain HypA PF01155.14 KII75203.1 - 0.59 9.8 7.0 0.56 9.9 2.1 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-C2H2_6 PF13912.1 KII75203.1 - 1 9.3 0.1 1 9.3 0.0 3.2 3 1 0 3 3 3 0 C2H2-type zinc finger Zn_ribbon_recom PF13408.1 KII75203.1 - 2.2 8.6 13.5 0.23 11.7 1.0 2.9 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain PHD PF00628.24 KII75203.1 - 6.1 6.6 13.3 1.1 8.9 1.9 2.9 2 1 0 2 2 2 0 PHD-finger ADK_lid PF05191.9 KII75203.1 - 7.3 6.3 10.2 8.4 6.1 0.0 3.3 4 0 0 4 4 4 0 Adenylate kinase, active site lid COP23 PF14218.1 KII75204.1 - 0.13 11.7 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Circadian oscillating protein COP23 Ecm33 PF12454.3 KII75205.1 - 1.1 9.1 3.0 3.7 7.5 2.1 1.9 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Hce2 PF14856.1 KII75208.1 - 0.068 13.0 0.1 0.09 12.6 0.0 1.3 1 0 0 1 1 1 0 Pathogen effector; putative necrosis-inducing factor IMPDH PF00478.20 KII75208.1 - 0.1 11.4 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain Glyco_transf_10 PF00852.14 KII75211.1 - 4.7e-42 143.7 2.5 5.3e-42 143.6 1.7 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) Glyco_transf_10 PF00852.14 KII75213.1 - 1.2e-31 109.5 0.1 1.3e-31 109.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) Ldl_recept_a PF00057.13 KII75214.1 - 1.4e-06 28.0 12.5 1.4e-06 28.0 8.7 3.6 5 0 0 5 5 5 1 Low-density lipoprotein receptor domain class A BNR PF02012.15 KII75214.1 - 1.5 8.9 9.2 9.1 6.5 0.0 3.9 4 0 0 4 4 4 0 BNR/Asp-box repeat Frag1 PF10277.4 KII75215.1 - 0.00012 21.5 15.0 0.00015 21.3 10.4 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF832 PF05734.6 KII75215.1 - 0.087 12.0 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus protein of unknown function (DUF832) Tmemb_170 PF10190.4 KII75215.1 - 7.4 6.6 15.8 1.4 9.0 0.8 2.8 2 1 0 2 2 2 0 Putative transmembrane protein 170 Frag1 PF10277.4 KII75216.1 - 9.6e-08 31.7 16.1 9.6e-08 31.7 11.2 2.0 1 1 1 2 2 2 1 Frag1/DRAM/Sfk1 family EamA PF00892.15 KII75216.1 - 0.0057 16.6 5.5 0.012 15.7 3.8 1.4 1 0 0 1 1 1 1 EamA-like transporter family HTH_Tnp_4 PF13613.1 KII75219.1 - 0.03 13.8 2.0 0.27 10.8 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix of DDE superfamily endonuclease SCO1-SenC PF02630.9 KII75226.1 - 0.0062 16.1 0.7 0.009 15.6 0.3 1.4 1 1 0 1 1 1 1 SCO1/SenC CDP-OH_P_tran_2 PF08009.6 KII75226.1 - 7.2 6.4 8.3 0.43 10.3 1.0 2.3 2 0 0 2 2 2 0 CDP-alcohol phosphatidyltransferase 2 ARL2_Bind_BART PF11527.3 KII75228.1 - 0.092 12.5 0.1 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART