# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF4517 PF15006.6 KII60210.1 - 2e-10 41.0 0.1 2.5e-10 40.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4517) MULE PF10551.9 KII60211.1 - 6e-06 26.6 0.0 1e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 MULE transposase domain DUF1955 PF09205.10 KII60211.1 - 0.099 12.4 0.1 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) Pkinase PF00069.25 KII60212.1 - 0.00033 20.1 0.0 0.00035 20.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KII60214.1 - 0.0008 19.5 0.1 0.0015 18.6 0.1 1.5 1 0 0 1 1 1 1 SH2 domain Annexin PF00191.20 KII60215.1 - 0.081 13.0 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Annexin COX17 PF05051.13 KII60215.1 - 0.099 13.0 0.5 0.099 13.0 0.5 1.7 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) rve PF00665.26 KII60220.1 - 6.1e-19 68.4 0.0 1.4e-18 67.2 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60220.1 - 4.1e-15 55.6 0.3 1e-14 54.4 0.3 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII60220.1 - 0.00015 21.5 0.0 0.00034 20.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII60220.1 - 0.0067 16.6 0.2 0.011 15.9 0.2 1.4 1 0 0 1 1 1 1 H2C2 zinc finger Forkhead PF00250.18 KII60220.1 - 0.021 15.1 0.0 0.052 13.8 0.0 1.6 1 0 0 1 1 1 0 Forkhead domain RT_RNaseH_2 PF17919.1 KII60221.1 - 4.4e-32 110.1 0.0 3.9e-30 103.8 0.0 3.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60221.1 - 2.5e-26 92.0 0.0 1.3e-24 86.5 0.0 3.4 5 0 0 5 5 5 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII60221.1 - 5.9e-23 81.6 0.1 2.3e-22 79.6 0.0 2.1 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII60221.1 - 4.5e-09 36.7 0.0 1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII60221.1 - 3.7e-07 30.7 0.0 7.9e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII60221.1 - 0.00028 21.2 0.0 0.00081 19.7 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease Cas_Cas02710 PF09670.10 KII60221.1 - 0.01 14.7 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) HTH_9 PF08221.11 KII60227.1 - 0.012 15.7 0.6 0.075 13.1 0.1 2.3 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Dimer_Tnp_hAT PF05699.14 KII60230.1 - 3.7e-07 29.9 0.1 5.1e-07 29.4 0.1 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Sigma_reg_N PF13800.6 KII60234.1 - 0.071 13.4 0.5 0.071 13.4 0.5 2.1 1 1 2 3 3 3 0 Sigma factor regulator N-terminal FtsX PF02687.21 KII60234.1 - 0.15 12.5 5.1 0.24 11.9 5.1 1.4 1 1 0 1 1 1 0 FtsX-like permease family Wzy_C PF04932.15 KII60234.1 - 0.37 10.4 9.6 1.1 8.9 1.6 2.0 1 1 1 2 2 2 0 O-Antigen ligase DUF4203 PF13886.6 KII60234.1 - 0.78 9.4 8.5 0.14 11.8 1.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4203) Syndecan PF01034.20 KII60235.1 - 1.5 8.8 6.5 6.5 6.8 0.0 3.2 3 0 0 3 3 3 0 Syndecan domain Neuroparsin PF07327.11 KII60239.1 - 0.12 12.9 1.1 0.17 12.3 1.1 1.3 1 0 0 1 1 1 0 Neuroparsin RT_RNaseH PF17917.1 KII60240.1 - 1.6e-18 66.9 0.0 4.3e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII60240.1 - 6.9e-13 48.5 0.4 1.5e-10 41.0 0.1 3.1 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase DUF2700 PF10912.8 KII60240.1 - 0.021 14.9 0.2 0.03 14.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2700) DUF986 PF06173.12 KII60240.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF986) rve PF00665.26 KII60242.1 - 2.6e-13 50.2 0.0 4.1e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII60242.1 - 4.2e-05 23.2 0.0 0.00012 21.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain DUF3254 PF11630.8 KII60243.1 - 0.11 12.6 0.1 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3254) DDE_Tnp_IS1595 PF12762.7 KII60245.1 - 3.1e-15 56.5 0.0 4e-15 56.1 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII60246.1 - 2e-20 73.0 0.0 3.4e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Imm-NTF2-2 PF15631.6 KII60246.1 - 0.14 12.4 0.2 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 NTF2 fold immunity protein Ribosomal_L18_c PF14204.6 KII60247.1 - 0.0021 19.0 0.2 0.006 17.5 0.2 1.7 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region zf-CCHC_3 PF13917.6 KII60247.1 - 0.029 14.3 9.5 0.8 9.7 1.3 2.7 1 1 1 2 2 2 0 Zinc knuckle DUF4070 PF13282.6 KII60247.1 - 0.11 12.6 1.1 0.41 10.7 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4070) zf-CCHC_4 PF14392.6 KII60247.1 - 0.68 9.7 7.2 5.7 6.8 1.1 2.5 2 0 0 2 2 2 0 Zinc knuckle Mito_carr PF00153.27 KII60249.1 - 1.9e-16 59.7 0.0 2.3e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein SIX1_SD PF16878.5 KII60252.1 - 0.023 15.2 0.0 0.033 14.7 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator, SIX1, N-terminal SD domain UQ_con PF00179.26 KII60253.1 - 5.9e-32 110.2 0.6 6.7e-32 110.0 0.6 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KII60253.1 - 0.0018 18.6 0.7 0.0029 17.9 0.7 1.5 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KII60253.1 - 0.052 13.3 0.0 0.063 13.0 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B SeleniumBinding PF11524.8 KII60255.1 - 0.017 15.5 0.1 0.041 14.3 0.1 1.6 1 0 0 1 1 1 0 Selenium binding protein HTH_33 PF13592.6 KII60259.1 - 0.0027 17.3 0.0 0.013 15.2 0.0 2.1 2 1 0 2 2 2 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII60259.1 - 0.0055 16.9 0.2 0.01 16.0 0.2 1.4 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 KII60259.1 - 0.025 15.2 0.0 0.052 14.2 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Arg_repressor PF01316.21 KII60259.1 - 0.034 13.9 0.4 0.054 13.3 0.4 1.3 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DDE_3 PF13358.6 KII60259.1 - 0.045 13.5 0.1 5.5 6.7 0.1 2.3 1 1 1 2 2 2 0 DDE superfamily endonuclease Glycos_transf_2 PF00535.26 KII60262.1 - 1.4e-28 99.8 0.0 2.4e-28 99.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 KII60262.1 - 1.1e-10 41.4 0.1 1.8e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 KII60262.1 - 4.6e-10 39.8 0.0 7.4e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KII60262.1 - 0.027 15.0 0.1 0.079 13.5 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase family 2 Mgr1 PF08602.10 KII60263.1 - 0.016 14.1 2.2 0.017 14.0 2.2 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Pkinase PF00069.25 KII60264.1 - 1.6e-57 194.8 0.1 2.1e-57 194.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII60264.1 - 1.5e-28 99.8 0.0 1.9e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII60264.1 - 2.5e-06 27.0 0.0 4.2e-06 26.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KII60264.1 - 0.0017 17.2 0.0 0.0029 16.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KII60264.1 - 0.048 13.0 0.1 0.083 12.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Inos-1-P_synth PF01658.17 KII60264.1 - 0.11 12.8 0.3 0.21 11.9 0.3 1.5 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase APH PF01636.23 KII60264.1 - 0.2 11.5 0.0 0.84 9.5 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family cNMP_binding PF00027.29 KII60265.1 - 9.8e-11 41.6 0.0 2e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PKcGMP_CC PF16808.5 KII60265.1 - 0.022 14.6 3.0 0.056 13.3 3.0 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Bac_DNA_binding PF00216.21 KII60265.1 - 0.036 14.2 1.5 0.41 10.9 0.1 2.4 2 0 0 2 2 2 0 Bacterial DNA-binding protein Tn7_Tnp_TnsA_C PF08721.11 KII60265.1 - 0.078 13.6 0.8 0.3 11.7 0.1 2.2 2 0 0 2 2 2 0 TnsA endonuclease C terminal ArsR PF09824.9 KII60265.1 - 0.094 12.3 2.5 0.18 11.4 0.1 2.0 2 0 0 2 2 2 0 ArsR transcriptional regulator AAA_13 PF13166.6 KII60265.1 - 0.12 10.9 5.6 0.024 13.3 1.1 1.7 1 1 1 2 2 2 0 AAA domain TMEM214 PF10151.9 KII60265.1 - 2.8 6.3 7.4 0.53 8.7 3.0 1.7 2 0 0 2 2 2 0 TMEM214, C-terminal, caspase 4 activator Dus PF01207.17 KII60268.1 - 4.4e-44 150.8 0.0 5.6e-44 150.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) FMN_dh PF01070.18 KII60268.1 - 0.0089 15.1 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 KII60268.1 - 0.052 12.8 0.0 2.8 7.0 0.0 2.1 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase zf-Di19 PF05605.12 KII60270.1 - 0.0023 18.2 3.9 0.6 10.5 1.1 2.2 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding PriA_CRR PF18319.1 KII60270.1 - 0.0027 17.7 2.2 0.0027 17.7 2.2 2.0 2 0 0 2 2 2 1 PriA DNA helicase Cys-rich region (CRR) domain zf-C2H2_4 PF13894.6 KII60270.1 - 0.0055 17.5 7.0 0.75 10.8 2.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-FCS PF06467.14 KII60270.1 - 0.019 14.9 6.8 0.083 12.8 0.9 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2 PF00096.26 KII60270.1 - 0.054 14.0 6.9 2.8 8.6 2.0 2.6 2 1 0 2 2 2 0 Zinc finger, C2H2 type DUF3449 PF11931.8 KII60270.1 - 0.059 13.2 0.2 0.081 12.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) PyrI_C PF02748.15 KII60270.1 - 0.079 12.9 4.2 1 9.3 0.2 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 KII60270.1 - 0.1 12.6 5.0 8 6.6 0.0 2.3 1 1 1 2 2 2 0 C2H2-type zinc finger Ima1_N PF09779.9 KII60270.1 - 0.49 11.3 4.1 3.7 8.4 3.3 2.0 1 1 1 2 2 2 0 Ima1 N-terminal domain Ldl_recept_a PF00057.18 KII60272.1 - 2.4e-36 123.6 69.4 1.3e-11 44.5 13.3 4.1 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII60274.1 - 2.4e-08 33.2 0.2 2.5e-08 33.2 0.2 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, HEPN_MAE_28990 PF18737.1 KII60278.1 - 0.015 15.2 1.6 0.015 15.2 1.6 1.6 1 1 1 2 2 2 0 MAE_28990/MAE_18760-like HEPN Glycos_transf_1 PF00534.20 KII60278.1 - 0.064 12.8 0.2 0.16 11.5 0.1 1.7 1 1 1 2 2 2 0 Glycosyl transferases group 1 DDE_3 PF13358.6 KII60279.1 - 4e-14 52.6 0.0 7.8e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII60279.1 - 7.2e-09 35.2 0.7 4.7e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_32 PF13565.6 KII60279.1 - 6.2e-06 26.7 0.0 2.9e-05 24.6 0.0 2.2 3 0 0 3 3 3 1 Homeodomain-like domain HTH_29 PF13551.6 KII60279.1 - 1e-05 25.4 0.1 8.2e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn helix PAX PF00292.18 KII60279.1 - 2.5e-05 24.2 0.6 4.4e-05 23.4 0.6 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_28 PF13518.6 KII60279.1 - 3.2e-05 24.0 0.0 0.0043 17.1 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII60279.1 - 4.2e-05 23.7 0.3 0.00062 20.0 0.0 2.5 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.6 KII60279.1 - 9.3e-05 22.0 0.1 0.00016 21.2 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_24 PF13412.6 KII60279.1 - 0.00011 21.6 0.1 0.44 10.1 0.0 2.6 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_Tnp_1 PF01527.20 KII60279.1 - 0.00022 21.5 0.0 0.00075 19.8 0.0 1.8 1 1 1 2 2 2 1 Transposase HTH_Tnp_ISL3 PF13542.6 KII60279.1 - 0.0025 17.2 0.4 0.54 9.7 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_38 PF13936.6 KII60279.1 - 0.029 14.1 2.5 0.039 13.7 0.1 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain Fe_dep_repress PF01325.19 KII60279.1 - 0.036 14.3 0.0 0.099 12.9 0.0 1.7 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain MarR_2 PF12802.7 KII60279.1 - 0.052 13.4 0.0 0.76 9.7 0.0 2.3 2 0 0 2 2 2 0 MarR family CENP-B_N PF04218.13 KII60279.1 - 0.19 11.4 3.5 0.62 9.7 0.4 2.7 3 0 0 3 3 3 0 CENP-B N-terminal DNA-binding domain HTH_11 PF08279.12 KII60279.1 - 0.2 11.6 1.9 13 5.8 0.1 2.7 2 0 0 2 2 2 0 HTH domain Bot1p PF12298.8 KII60279.1 - 0.98 9.6 3.2 3.4 7.8 0.6 2.6 3 0 0 3 3 3 0 Eukaryotic mitochondrial regulator protein DHHC PF01529.20 KII60282.1 - 1.2e-32 112.9 15.4 1.5e-32 112.5 15.4 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase GST_C_6 PF17171.4 KII60282.1 - 0.12 12.2 3.0 0.95 9.3 2.6 2.7 3 1 0 3 3 3 0 Glutathione S-transferase, C-terminal domain V_ATPase_I PF01496.19 KII60285.1 - 3.7e-220 733.0 23.5 1.4e-120 403.6 13.7 2.4 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family TBPIP PF07106.13 KII60286.1 - 5.7e-11 42.2 5.1 8.1e-10 38.5 5.1 2.4 1 1 0 1 1 1 1 TBPIP/Hop2 winged helix domain Csm1_N PF18504.1 KII60286.1 - 0.038 14.3 1.2 0.038 14.3 1.2 2.3 2 1 0 2 2 2 0 Csm1 N-terminal domain EFP_N PF08207.12 KII60286.1 - 0.059 13.4 0.1 0.68 10.0 0.1 2.2 2 0 0 2 2 2 0 Elongation factor P (EF-P) KOW-like domain Com_YlbF PF06133.11 KII60286.1 - 0.088 13.4 7.4 0.16 12.6 7.4 1.6 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA ABC_tran_CTD PF16326.5 KII60286.1 - 0.28 11.5 5.0 0.4 11.0 0.2 2.7 2 1 1 3 3 3 0 ABC transporter C-terminal domain FliD_N PF02465.18 KII60286.1 - 0.5 11.1 7.6 2.8 8.7 0.8 2.7 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus FlxA PF14282.6 KII60286.1 - 4.3 7.4 10.7 0.13 12.3 1.8 2.4 2 1 0 2 2 2 0 FlxA-like protein Inhibitor_I29 PF08246.12 KII60287.1 - 2.2e-09 37.6 5.1 3.3e-09 37.0 5.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.23 KII60287.1 - 1.5e-08 35.0 0.6 2.7e-08 34.2 0.1 1.6 2 0 0 2 2 2 1 Papain family cysteine protease Peptidase_C1 PF00112.23 KII60288.1 - 1.8e-08 34.8 0.7 2.7e-08 34.2 0.1 1.6 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII60288.1 - 2.8e-08 34.1 5.2 4.2e-08 33.5 5.2 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Ribosomal_L30_N PF08079.12 KII60288.1 - 0.14 12.4 3.0 0.4 11.0 1.2 2.0 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain PGA2 PF07543.12 KII60289.1 - 0.034 14.1 0.8 0.066 13.2 0.8 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 Peptidase_C1 PF00112.23 KII60291.1 - 3.5e-67 226.7 0.0 5.2e-67 226.1 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII60291.1 - 7.3e-07 29.5 2.1 1.4e-06 28.6 2.1 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KII60291.1 - 0.016 14.0 0.1 1.1 8.0 0.0 2.4 2 1 0 2 2 2 0 Peptidase C1-like family Got1 PF04178.12 KII60292.1 - 0.011 16.1 0.6 0.015 15.8 0.6 1.1 1 0 0 1 1 1 0 Got1/Sft2-like family MLANA PF14991.6 KII60292.1 - 0.071 13.4 0.0 0.071 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein melan-A CD34_antigen PF06365.12 KII60292.1 - 0.16 11.5 0.1 0.19 11.3 0.1 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family tRNA-synt_1 PF00133.22 KII60293.1 - 3.9e-140 468.0 0.0 1.4e-138 462.8 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KII60293.1 - 3.8e-34 117.9 0.6 6.6e-34 117.1 0.6 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KII60293.1 - 2e-07 30.1 0.1 0.0016 17.3 0.1 3.7 3 1 0 4 4 4 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 KII60293.1 - 7.5e-06 25.6 0.1 0.00034 20.2 0.0 2.5 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 KII60293.1 - 0.043 14.1 1.9 0.074 13.4 1.9 1.4 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1b PF00579.25 KII60293.1 - 0.15 11.4 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) NT5C PF06941.12 KII60294.1 - 0.22 11.4 0.0 0.27 11.1 0.0 1.1 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) RVT_1 PF00078.27 KII60296.1 - 6e-24 84.8 0.2 1.1e-23 83.9 0.2 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII60299.1 - 4.3e-05 23.4 10.1 0.0011 18.9 0.7 3.1 3 0 0 3 3 3 2 Zinc knuckle RVP PF00077.20 KII60299.1 - 8.6e-05 22.8 0.1 0.049 13.9 0.0 2.3 1 1 1 2 2 2 2 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 KII60299.1 - 0.021 14.6 8.3 0.13 12.0 1.0 3.1 3 0 0 3 3 3 0 Zinc knuckle MULE PF10551.9 KII60300.1 - 2.8e-05 24.4 0.0 4.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 MULE transposase domain Kazal_3 PF18434.1 KII60301.1 - 0.032 14.0 0.1 5.2 6.9 0.1 2.6 2 1 0 2 2 2 0 Kazal-type serine protease inhibitor domain RVT_1 PF00078.27 KII60302.1 - 2.4e-13 50.1 1.0 8.8e-12 45.0 0.0 2.9 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII60302.1 - 0.00074 19.8 0.0 0.0019 18.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII60302.1 - 0.0013 18.7 0.0 0.0032 17.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase MLVIN_C PF18697.1 KII60307.1 - 0.0072 16.4 0.0 0.018 15.1 0.0 1.8 1 1 1 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain zf-LYAR PF08790.11 KII60309.1 - 0.2 11.6 1.1 0.3 11.0 0.1 1.8 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Get5_C PF18514.1 KII60310.1 - 0.23 11.2 0.1 0.42 10.4 0.1 1.4 1 0 0 1 1 1 0 Get5 C-terminal domain RVT_1 PF00078.27 KII60312.1 - 2e-10 40.6 0.1 3.5e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII60313.1 - 5.2e-15 55.7 0.0 7.1e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII60313.1 - 0.027 14.2 0.0 0.063 13.1 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain dNK PF01712.19 KII60313.1 - 0.032 14.1 1.0 0.059 13.2 1.0 1.4 1 1 0 1 1 1 0 Deoxynucleoside kinase Gmad2 PF10648.9 KII60316.1 - 0.034 14.4 0.0 0.13 12.5 0.0 1.8 1 1 1 2 2 2 0 Immunoglobulin-like domain of bacterial spore germination Prok-E2_A PF14457.6 KII60318.1 - 0.062 12.9 0.0 0.096 12.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family A Myb_DNA-binding PF00249.31 KII60321.1 - 8.7e-08 32.2 0.1 2.8e-07 30.6 0.2 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII60321.1 - 8e-05 22.8 0.3 0.00035 20.8 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain SLIDE PF09111.10 KII60321.1 - 0.33 11.0 4.9 0.17 11.9 0.7 2.6 2 1 0 2 2 2 0 SLIDE HTH_32 PF13565.6 KII60322.1 - 3.1e-09 37.3 0.3 6.4e-06 26.7 0.0 2.2 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII60322.1 - 3.2e-07 30.5 1.3 7.4e-06 26.1 0.0 2.9 2 2 1 3 3 3 1 Transposase HTH_23 PF13384.6 KII60322.1 - 2e-06 27.4 0.2 0.00037 20.2 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 KII60322.1 - 4.1e-06 26.1 0.0 9.1e-05 21.8 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 KII60322.1 - 1.3e-05 25.2 0.4 0.0012 18.9 0.2 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.6 KII60322.1 - 3e-05 23.5 0.3 0.0094 15.5 0.0 3.1 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_DeoR PF08220.12 KII60322.1 - 0.00015 21.4 0.4 0.014 15.2 0.0 2.5 2 1 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_Tnp_IS630 PF01710.16 KII60322.1 - 0.004 17.2 0.6 0.0069 16.4 0.6 1.4 1 0 0 1 1 1 1 Transposase PAX PF00292.18 KII60322.1 - 0.012 15.6 0.3 0.042 13.8 0.2 1.8 1 1 1 2 2 2 0 'Paired box' domain CENP-B_N PF04218.13 KII60322.1 - 0.012 15.2 0.4 0.11 12.1 0.1 2.4 2 1 1 3 3 3 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.20 KII60322.1 - 0.015 15.6 0.3 0.14 12.5 0.2 2.2 2 0 0 2 2 2 0 Transposase HTH_11 PF08279.12 KII60322.1 - 0.018 15.0 0.1 7 6.7 0.0 2.5 2 0 0 2 2 2 0 HTH domain HTH_AraC PF00165.23 KII60322.1 - 0.025 14.7 0.0 0.097 12.8 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family FeoC PF09012.10 KII60322.1 - 0.037 14.1 0.0 0.064 13.3 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator Rrf2 PF02082.20 KII60322.1 - 0.059 13.7 0.2 0.43 11.0 0.0 2.2 2 1 0 2 2 2 0 Transcriptional regulator HTH_Tnp_4 PF13613.6 KII60322.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease GCR1_C PF12550.8 KII60322.1 - 0.14 12.5 1.8 1.1 9.6 0.4 2.4 2 1 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Ribosom_S30AE_C PF16321.5 KII60325.1 - 0.043 13.5 0.2 0.069 12.9 0.2 1.3 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus RIC1 PF07064.13 KII60327.1 - 0.052 13.0 0.2 0.057 12.8 0.2 1.1 1 0 0 1 1 1 0 RIC1 DDE_Tnp_IS1595 PF12762.7 KII60330.1 - 8.3e-07 29.1 0.0 1.2e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain CfAFP PF05264.11 KII60331.1 - 1.1e-05 25.5 2.2 1.9 8.5 0.1 3.5 1 1 2 3 3 3 3 Choristoneura fumiferana antifreeze protein (CfAFP) GATase_6 PF13522.6 KII60332.1 - 0.00022 21.5 0.0 0.00024 21.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KII60332.1 - 0.041 12.8 0.0 0.052 12.4 0.0 1.1 1 0 0 1 1 1 0 Glutamine amidotransferases class-II Hepsin-SRCR PF09272.10 KII60332.1 - 0.11 13.0 0.0 0.13 12.8 0.0 1.1 1 0 0 1 1 1 0 Hepsin, SRCR domain MULE PF10551.9 KII60333.1 - 0.11 12.9 0.0 0.38 11.2 0.0 1.7 2 0 0 2 2 2 0 MULE transposase domain Aldedh PF00171.22 KII60335.1 - 3.5e-53 180.8 0.0 5.1e-42 143.9 0.0 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family HhH-GPD PF00730.25 KII60336.1 - 1.8e-11 44.4 0.0 5.2e-11 43.0 0.0 1.9 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 KII60336.1 - 4.6e-10 39.5 0.0 7.9e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.23 KII60336.1 - 0.00035 20.3 0.0 0.0011 18.7 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 KII60336.1 - 0.042 14.2 4.5 0.1 12.9 4.5 1.7 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III DDE_3 PF13358.6 KII60337.1 - 5.6e-07 29.4 0.0 1.2e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH_2 PF17919.1 KII60338.1 - 9.8e-10 38.4 0.0 1.7e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII60338.1 - 5.3e-07 29.4 0.1 7.7e-07 28.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DNA_pol_viral_C PF00336.18 KII60338.1 - 0.0016 17.9 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain RT_RNaseH PF17917.1 KII60338.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Ribosomal_L22e PF01776.17 KII60340.1 - 6e-36 123.1 0.9 8e-36 122.7 0.9 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family CT_A_B PF02626.15 KII60340.1 - 0.23 11.1 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain A and B Lyase_1 PF00206.20 KII60341.1 - 1e-94 317.4 0.0 1.4e-94 317.1 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 KII60341.1 - 3.4e-23 81.8 0.1 6.4e-23 80.9 0.1 1.5 1 0 0 1 1 1 1 Fumarase C C-terminus LCCL PF03815.19 KII60341.1 - 0.027 14.6 0.1 0.07 13.2 0.0 1.8 2 0 0 2 2 2 0 LCCL domain DDE_3 PF13358.6 KII60342.1 - 0.00095 18.9 0.0 0.0039 17.0 0.0 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF2303 PF10065.9 KII60342.1 - 0.017 14.2 0.4 0.26 10.4 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2303) DUF4922 PF16269.5 KII60342.1 - 0.45 10.3 4.3 0.93 9.2 1.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4922) 7tm_1 PF00001.21 KII60344.1 - 2.9e-16 59.6 11.0 2.9e-16 59.6 11.0 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KII60344.1 - 1.4e-07 31.2 14.3 1.9e-07 30.7 14.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DPM2 PF07297.12 KII60344.1 - 0.0023 18.2 3.0 0.0023 18.2 3.0 2.0 3 0 0 3 3 3 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4231 PF14015.6 KII60344.1 - 0.11 13.0 3.8 7.3 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) UPF0182 PF03699.13 KII60344.1 - 0.37 8.9 8.1 0.46 8.5 8.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Mesd PF10185.9 KII60345.1 - 4.7e-09 36.4 10.3 1.9e-07 31.1 10.3 2.0 1 1 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor SOG2 PF10428.9 KII60347.1 - 0.74 8.9 18.1 0.93 8.6 18.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein G_glu_transpept PF01019.21 KII60348.1 - 3.6e-119 398.8 0.0 2.7e-109 366.3 0.0 2.0 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase Sortilin-Vps10 PF15902.5 KII60350.1 - 0.066 12.0 0.2 0.081 11.7 0.2 1.0 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, NADH-UOR_E PF16514.5 KII60350.1 - 0.13 12.6 0.1 0.19 12.0 0.1 1.3 1 0 0 1 1 1 0 putative NADH-ubiquinone oxidoreductase chain E Ldl_recept_a PF00057.18 KII60351.1 - 8.7e-21 73.9 46.1 5.2e-12 45.8 13.9 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A RT_RNaseH_2 PF17919.1 KII60352.1 - 8.4e-34 115.6 0.0 2.4e-33 114.1 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60352.1 - 9.7e-34 115.8 0.0 4.6e-33 113.6 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII60352.1 - 1.4e-18 67.2 0.0 3.2e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60352.1 - 8.8e-17 61.0 0.0 2e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII60352.1 - 1.7e-08 34.2 0.1 4.2e-08 33.0 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 KII60352.1 - 0.00067 19.4 0.1 0.0016 18.2 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain tRNA-synt_His PF13393.6 KII60354.1 - 0.11 11.7 0.3 0.19 11.0 0.3 1.3 1 0 0 1 1 1 0 Histidyl-tRNA synthetase P4Ha_N PF08336.11 KII60357.1 - 6.3e-15 55.4 0.2 1.2e-14 54.5 0.2 1.5 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_12 PF13424.6 KII60357.1 - 0.062 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII60357.1 - 0.073 12.9 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DDE_1 PF03184.19 KII60358.1 - 0.021 14.5 0.1 0.041 13.5 0.1 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease Kelch_4 PF13418.6 KII60359.1 - 2.4e-14 53.1 14.4 0.0099 15.9 0.1 6.7 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII60359.1 - 5.9e-11 41.8 22.0 4.7e-06 26.1 0.9 6.8 6 2 1 7 7 7 3 Kelch motif Kelch_6 PF13964.6 KII60359.1 - 4.6e-10 39.4 19.2 0.0015 18.8 0.7 6.6 6 2 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII60359.1 - 2.2e-08 34.2 9.7 0.74 10.2 0.2 6.7 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII60359.1 - 0.00015 21.6 12.2 0.26 11.3 0.2 5.6 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 KII60359.1 - 0.00023 21.0 11.0 0.37 10.9 0.0 5.6 6 0 0 6 6 6 2 Kelch motif PHD PF00628.29 KII60360.1 - 1.9e-06 27.6 8.9 1.9e-06 27.6 8.9 1.9 2 0 0 2 2 2 1 PHD-finger Bromo_TP PF07524.13 KII60360.1 - 1.7e-05 24.8 0.1 2.7e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated PHD_2 PF13831.6 KII60360.1 - 3.4e-05 23.3 2.7 7.4e-05 22.2 2.7 1.6 1 0 0 1 1 1 1 PHD-finger C1_2 PF03107.16 KII60360.1 - 0.0029 17.9 1.4 0.0097 16.2 1.4 2.0 1 0 0 1 1 1 1 C1 domain Zf_RING PF16744.5 KII60360.1 - 0.006 16.7 9.8 0.32 11.2 9.8 2.5 1 1 0 1 1 1 1 KIAA1045 RING finger Prok-RING_1 PF14446.6 KII60360.1 - 0.013 15.4 3.0 0.013 15.4 3.0 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 KII60360.1 - 0.015 15.6 7.5 0.036 14.4 7.5 1.7 1 0 0 1 1 1 0 Ring finger domain C1_1 PF00130.22 KII60360.1 - 0.017 15.0 3.1 0.017 15.0 3.1 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RecR PF02132.15 KII60360.1 - 0.03 13.9 1.3 0.083 12.5 1.3 1.7 1 0 0 1 1 1 0 RecR protein FYVE_2 PF02318.16 KII60360.1 - 0.074 13.3 3.8 0.19 12.0 3.8 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger PHD_4 PF16866.5 KII60360.1 - 3.1 8.0 12.7 7.4 6.7 8.6 3.0 2 1 0 2 2 2 0 PHD-finger Sortilin_C PF15901.5 KII60361.1 - 3.1e-08 34.2 1.2 6.2e-08 33.2 1.2 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII60361.1 - 1.8e-06 27.0 0.6 3.7e-06 26.0 0.6 1.4 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, RVT_1 PF00078.27 KII60362.1 - 1.9e-31 109.3 0.5 5.2e-31 107.9 0.5 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII60362.1 - 6e-06 26.2 0.1 1.6e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase gag-asp_proteas PF13975.6 KII60362.1 - 6.1e-06 26.7 0.0 1.8e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII60362.1 - 2.7e-05 24.0 3.9 7.1e-05 22.7 3.9 1.7 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 KII60362.1 - 0.00041 20.9 0.0 0.001 19.7 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_4 PF14392.6 KII60362.1 - 0.0079 15.9 1.2 0.036 13.8 1.3 2.0 2 0 0 2 2 2 1 Zinc knuckle RVP PF00077.20 KII60362.1 - 0.029 14.7 0.0 0.07 13.4 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF4845 PF16137.5 KII60362.1 - 0.15 13.0 0.5 17 6.3 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4845) Ldl_recept_a PF00057.18 KII60363.1 - 7.7e-06 26.0 13.6 7.7e-06 26.0 13.6 3.4 2 1 2 4 4 4 2 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII60364.1 - 1.3e-12 48.4 2.3 1.8e-12 47.9 2.3 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal MiAMP1 PF09117.10 KII60364.1 - 0.055 13.7 1.5 0.11 12.7 1.0 1.8 1 1 1 2 2 2 0 MiAMP1 Sortilin-Vps10 PF15902.5 KII60364.1 - 0.32 9.7 4.3 0.061 12.1 1.0 1.4 2 0 0 2 2 2 0 Sortilin, neurotensin receptor 3, CDC45 PF02724.14 KII60365.1 - 0.0091 14.3 1.0 0.0097 14.3 1.0 1.0 1 0 0 1 1 1 1 CDC45-like protein DNA_pol_phi PF04931.13 KII60365.1 - 0.06 11.5 8.9 0.069 11.3 8.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi 2OG-FeII_Oxy_3 PF13640.6 KII60365.1 - 0.11 13.4 0.0 0.19 12.6 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Nop14 PF04147.12 KII60365.1 - 0.42 8.8 7.8 0.5 8.5 7.8 1.0 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 KII60365.1 - 3.3 6.1 9.4 4.2 5.8 9.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ldl_recept_a PF00057.18 KII60366.1 - 3e-08 33.7 15.9 3e-08 33.7 15.9 2.4 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A DUF4024 PF13216.6 KII60366.1 - 0.25 11.3 1.5 0.6 10.1 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) Ldl_recept_a PF00057.18 KII60367.1 - 3e-08 33.7 15.9 3e-08 33.7 15.9 2.4 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A DUF4024 PF13216.6 KII60367.1 - 0.25 11.3 1.5 0.6 10.1 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) Sortilin_C PF15901.5 KII60368.1 - 1.7e-09 38.3 1.2 2e-09 38.0 1.2 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII60368.1 - 1.7e-05 23.8 0.1 2.1e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII60368.1 - 0.26 11.4 7.1 2.2 8.6 0.1 2.7 2 0 0 2 2 2 0 BNR/Asp-box repeat BNR_6 PF15899.5 KII60368.1 - 3.2 8.1 7.1 29 5.1 0.2 2.7 2 0 0 2 2 2 0 BNR-Asp box repeat Sortilin_C PF15901.5 KII60370.1 - 1.9e-08 34.9 3.9 2.1e-08 34.7 3.9 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PAP_assoc PF03828.19 KII60370.1 - 0.01 16.0 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 0 Cid1 family poly A polymerase RAP PF08373.10 KII60371.1 - 0.0024 17.9 0.9 0.0039 17.2 0.3 1.6 2 0 0 2 2 2 1 RAP domain NUP214 PF16755.5 KII60371.1 - 0.063 12.5 0.4 0.11 11.8 0.3 1.5 1 1 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Sortilin_C PF15901.5 KII60372.1 - 3.8e-07 30.6 5.8 7.4e-07 29.7 1.1 2.2 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII60372.1 - 7.6e-05 21.7 4.1 9.8e-05 21.3 1.4 2.3 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII60372.1 - 0.0012 18.5 4.0 2.1 8.7 0.0 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF3908 PF13048.6 KII60372.1 - 0.17 12.2 3.9 3.9 7.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3908) Sortilin-Vps10 PF15902.5 KII60373.1 - 0.012 14.5 0.6 0.03 13.1 0.2 1.8 1 1 0 1 1 1 0 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII60374.1 - 3.6e-06 27.1 21.4 0.0012 19.0 8.0 3.1 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A Usp PF00582.26 KII60376.1 - 1.9e-07 31.7 0.0 3.5e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 Universal stress protein family OrfB_Zn_ribbon PF07282.11 KII60376.1 - 0.011 15.7 0.6 0.017 15.0 0.6 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain SecD-TM1 PF13721.6 KII60376.1 - 0.059 13.8 0.0 0.082 13.4 0.0 1.3 1 0 0 1 1 1 0 SecD export protein N-terminal TM region SseC PF04888.12 KII60376.1 - 0.11 12.1 0.5 0.14 11.8 0.5 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family RepL PF05732.11 KII60376.1 - 0.11 11.9 2.8 0.24 10.8 0.4 2.0 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) Nuf2 PF03800.14 KII60377.1 - 6.9e-10 39.2 1.7 6.9e-10 39.2 1.7 2.2 2 1 0 2 2 2 1 Nuf2 family ERM PF00769.19 KII60377.1 - 0.00051 19.9 6.3 0.00051 19.9 6.3 2.2 2 0 0 2 2 2 1 Ezrin/radixin/moesin family TRPM_tetra PF16519.5 KII60377.1 - 0.0034 17.4 0.5 0.0034 17.4 0.5 2.4 2 0 0 2 2 1 1 Tetramerisation domain of TRPM Lectin_N PF03954.14 KII60377.1 - 0.0044 16.8 4.9 0.0044 16.8 4.9 3.6 3 1 1 4 4 4 1 Hepatic lectin, N-terminal domain CENP-Q PF13094.6 KII60377.1 - 0.012 15.9 1.9 0.012 15.9 1.9 3.2 3 1 0 3 3 2 0 CENP-Q, a CENPA-CAD centromere complex subunit HALZ PF02183.18 KII60377.1 - 0.018 15.2 1.9 0.018 15.2 1.9 3.8 4 0 0 4 4 3 0 Homeobox associated leucine zipper Golgin_A5 PF09787.9 KII60377.1 - 0.02 14.4 28.1 0.019 14.5 9.5 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 CENP-F_leu_zip PF10473.9 KII60377.1 - 0.023 14.7 39.7 0.16 12.0 8.1 4.7 3 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 KII60377.1 - 0.028 13.7 38.2 0.018 14.4 14.5 2.8 2 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding Cypo_polyhedrin PF05865.11 KII60377.1 - 0.05 13.0 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 Cypovirus polyhedrin protein ACP_PD PF04336.12 KII60377.1 - 0.078 13.4 3.0 8.2 6.9 0.0 3.5 2 1 1 3 3 3 0 Acyl carrier protein phosphodiesterase AAA_13 PF13166.6 KII60377.1 - 0.079 11.6 33.3 0.81 8.3 11.8 2.1 1 1 1 2 2 2 0 AAA domain Fez1 PF06818.15 KII60377.1 - 0.16 12.4 23.1 1.4 9.4 8.0 2.3 2 0 0 2 2 2 0 Fez1 DUF4407 PF14362.6 KII60377.1 - 0.37 10.1 15.1 7.8 5.7 8.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 KII60377.1 - 0.77 10.3 36.5 0.24 11.9 11.4 3.6 2 2 1 3 3 3 0 Apg6 coiled-coil region DUF1664 PF07889.12 KII60377.1 - 1.6 8.8 24.7 0.44 10.6 5.2 3.2 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) HAUS-augmin3 PF14932.6 KII60377.1 - 2.9 7.4 29.2 5.7 6.4 10.9 3.1 1 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 ARTD15_N PF18084.1 KII60377.1 - 2.9 8.2 5.6 6.4 7.1 0.3 3.3 2 2 1 4 4 4 0 ARTD15 N-terminal domain EzrA PF06160.12 KII60377.1 - 4.9 5.2 38.5 34 2.4 38.2 2.7 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Na_H_Exchanger PF00999.21 KII60380.1 - 0.02 13.7 0.3 0.026 13.3 0.3 1.1 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family LapA_dom PF06305.11 KII60380.1 - 0.19 11.6 0.8 0.44 10.4 0.5 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RVT_1 PF00078.27 KII60381.1 - 2.5e-27 95.9 0.2 5.8e-27 94.6 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 KII60381.1 - 0.00027 21.2 0.0 0.00058 20.1 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KII60381.1 - 0.00077 19.2 1.3 0.0038 17.0 0.1 2.2 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII60381.1 - 0.0019 18.7 0.0 0.005 17.4 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII60381.1 - 0.012 16.2 0.0 0.025 15.2 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.6 KII60381.1 - 0.4 10.5 9.8 0.061 13.1 1.3 2.8 2 0 0 2 2 2 0 Zinc knuckle SH3_1 PF00018.28 KII60383.1 - 2.4e-15 55.8 0.1 5.3e-15 54.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KII60383.1 - 9.5e-14 51.0 0.1 2.1e-13 49.9 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KII60383.1 - 1.6e-11 43.7 0.0 3.9e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain VHS PF00790.19 KII60383.1 - 7.7e-05 22.6 1.2 7.7e-05 22.6 1.2 2.2 2 0 0 2 2 2 1 VHS domain UIM PF02809.20 KII60383.1 - 0.02 14.8 0.1 0.069 13.1 0.1 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif GAT PF03127.14 KII60383.1 - 0.46 10.8 11.3 0.087 13.1 4.8 3.0 3 0 0 3 3 3 0 GAT domain MerR_2 PF13591.6 KII60388.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 MerR HTH family regulatory protein HTH_Tnp_IS630 PF01710.16 KII60390.1 - 0.057 13.5 0.1 0.33 11.0 0.0 2.2 3 0 0 3 3 3 0 Transposase DUF4448 PF14610.6 KII60391.1 - 0.075 12.8 0.4 0.098 12.4 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Herpes_LMP1 PF05297.11 KII60391.1 - 0.17 11.1 2.6 0.21 10.7 2.6 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) LRS4 PF10422.9 KII60391.1 - 0.24 11.0 1.3 0.26 10.8 1.3 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 SNAP PF14938.6 KII60392.1 - 6.8e-05 22.4 0.6 0.00011 21.8 0.6 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP CTNNBL PF08216.11 KII60394.1 - 0.064 13.4 0.2 0.13 12.5 0.2 1.5 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear DDE_Tnp_IS1595 PF12762.7 KII60395.1 - 0.002 18.1 0.0 0.0025 17.8 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain GTP_EFTU PF00009.27 KII60396.1 - 3.4e-61 206.2 0.0 4.4e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KII60396.1 - 6e-06 26.6 0.0 1.3e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 SRPRB PF09439.10 KII60396.1 - 0.17 11.3 0.4 4 6.8 0.0 2.3 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KII60397.1 - 3.3e-35 121.4 0.0 5.3e-35 120.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KII60397.1 - 1.1e-29 102.7 0.0 2.4e-29 101.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 KII60397.1 - 9.4e-19 67.2 0.0 2.3e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KII60397.1 - 7.7e-15 54.8 0.0 2.2e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 KII60397.1 - 1.8e-06 28.2 0.0 4.4e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 HTH_23 PF13384.6 KII60398.1 - 7.7e-07 28.7 0.0 1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 KII60398.1 - 1.2e-06 28.4 0.0 1.6e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 KII60398.1 - 2.5e-06 27.5 0.0 5.5e-06 26.4 0.0 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_38 PF13936.6 KII60398.1 - 1.6e-05 24.5 0.0 0.00021 20.9 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII60398.1 - 0.002 18.1 0.1 0.0024 17.8 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_11 PF08279.12 KII60398.1 - 0.012 15.6 0.2 0.019 14.9 0.2 1.3 1 0 0 1 1 1 0 HTH domain HTH_Crp_2 PF13545.6 KII60398.1 - 0.013 15.5 0.1 0.033 14.2 0.0 1.6 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain HTH_7 PF02796.15 KII60398.1 - 0.018 15.1 0.6 0.082 13.0 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.16 KII60398.1 - 0.025 14.6 0.4 0.032 14.3 0.4 1.2 1 0 0 1 1 1 0 Transposase TrmB PF01978.19 KII60398.1 - 0.069 13.0 0.1 0.099 12.5 0.1 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sigma70_r4 PF04545.16 KII60398.1 - 0.092 12.3 0.0 0.38 10.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 MarR PF01047.22 KII60398.1 - 0.15 12.0 0.1 0.58 10.1 0.1 1.9 1 1 0 1 1 1 0 MarR family Sigma70_r4_2 PF08281.12 KII60398.1 - 0.19 11.4 0.1 0.56 9.9 0.0 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 Tna_leader PF08053.11 KII60399.1 - 2.9 8.0 8.8 19 5.4 0.4 3.9 1 1 3 4 4 4 0 Tryptophanase operon leader peptide Paralemmin PF03285.15 KII60402.1 - 0.059 12.9 0.5 0.071 12.7 0.5 1.0 1 0 0 1 1 1 0 Paralemmin DHR10 PF18595.1 KII60406.1 - 0.00021 21.3 0.5 38 4.4 0.0 5.3 1 1 7 8 8 8 1 Designed helical repeat protein 10 domain DUF1327 PF07041.11 KII60406.1 - 0.0014 18.7 17.2 76 3.4 0.1 7.9 1 1 8 9 9 9 0 Protein of unknown function (DUF1327) DUF1366 PF07104.11 KII60406.1 - 0.17 11.6 3.9 15 5.3 0.1 4.0 1 1 4 6 6 6 0 Protein of unknown function (DUF1366) T3SSipB PF16535.5 KII60406.1 - 7.2 7.1 43.3 9.8 6.6 3.9 5.6 1 1 6 7 7 7 0 Type III cell invasion protein SipB Abi_2 PF07751.11 KII60407.1 - 0.089 13.0 0.1 0.12 12.6 0.1 1.1 1 0 0 1 1 1 0 Abi-like protein HTH_9 PF08221.11 KII60409.1 - 0.013 15.6 0.6 0.075 13.1 0.1 2.3 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DnaJ PF00226.31 KII60411.1 - 1.1e-24 86.3 2.7 1.6e-24 85.8 2.7 1.3 1 0 0 1 1 1 1 DnaJ domain DUF1217 PF06748.12 KII60411.1 - 0.066 13.2 0.2 0.13 12.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1217) DUF493 PF04359.14 KII60411.1 - 0.25 11.9 1.1 1.6 9.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF493) DDE_1 PF03184.19 KII60413.1 - 1.2e-12 47.9 0.0 2.3e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4474 PF14751.6 KII60415.1 - 0.017 14.6 0.4 0.02 14.3 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4474) VPS28 PF03997.12 KII60415.1 - 0.018 14.7 0.5 0.025 14.3 0.5 1.2 1 0 0 1 1 1 0 VPS28 protein DUF573 PF04504.14 KII60415.1 - 0.4 11.4 6.9 0.29 11.8 3.7 1.9 1 1 1 2 2 2 0 Protein of unknown function, DUF573 TFIIS_M PF07500.14 KII60415.1 - 0.79 10.2 7.7 9.9 6.7 7.7 2.0 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain TMF_TATA_bd PF12325.8 KII60415.1 - 1.1 9.5 8.0 0.33 11.2 2.9 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TetR_C_23 PF17931.1 KII60415.1 - 1.3 9.1 9.3 5 7.3 1.1 2.1 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DDE_Tnp_IS1595 PF12762.7 KII60416.1 - 0.018 15.0 1.1 0.026 14.5 1.1 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain Sortilin_C PF15901.5 KII60417.1 - 2.9e-06 27.7 0.1 6.3e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII60417.1 - 4.8e-05 22.3 0.3 0.2 10.4 0.0 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII60417.1 - 0.00048 19.7 4.6 0.33 11.1 0.0 3.6 4 0 0 4 4 4 2 BNR/Asp-box repeat MFS_2 PF13347.6 KII60419.1 - 2.6e-59 200.9 35.1 4e-59 200.3 35.1 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein DUF5518 PF17647.1 KII60419.1 - 0.0028 17.8 0.0 0.0028 17.8 0.0 5.1 5 0 0 5 5 5 1 Family of unknown function (DUF5518) DUF2681 PF10883.8 KII60419.1 - 0.015 15.7 0.1 0.48 10.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF4605 PF15378.6 KII60419.1 - 0.025 14.4 0.4 0.025 14.4 0.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4605) UxaC PF02614.14 KII60420.1 - 8.4e-182 605.1 0.1 1.2e-181 604.7 0.1 1.2 1 0 0 1 1 1 1 Glucuronate isomerase UxuA PF03786.13 KII60421.1 - 7.3e-103 344.1 0.0 8.2e-103 343.9 0.0 1.0 1 0 0 1 1 1 1 D-mannonate dehydratase (UxuA) AP_endonuc_2 PF01261.24 KII60421.1 - 7.9e-08 32.0 0.0 9.9e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel MukB_hinge PF16330.5 KII60422.1 - 0.18 11.5 0.1 0.3 10.8 0.1 1.3 1 1 0 1 1 1 0 MukB hinge domain Acetyltransf_CG PF14542.6 KII60424.1 - 3.4e-20 72.0 0.0 6e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Fer4_19 PF06902.11 KII60424.1 - 9e-18 64.1 0.2 3.5e-17 62.2 0.1 1.9 2 0 0 2 2 2 1 Divergent 4Fe-4S mono-cluster Acetyltransf_1 PF00583.25 KII60424.1 - 7.5e-05 22.9 0.0 9.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII60424.1 - 0.00012 22.0 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII60424.1 - 0.00088 19.6 0.0 0.0014 19.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KII60424.1 - 0.042 13.9 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 KII60424.1 - 0.16 12.0 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein EAL PF00563.20 KII60425.1 - 6.6e-45 153.5 0.1 7.7e-45 153.3 0.1 1.0 1 0 0 1 1 1 1 EAL domain Fimbrial PF00419.20 KII60426.1 - 1.7e-23 83.6 0.0 2e-23 83.4 0.0 1.0 1 0 0 1 1 1 1 Fimbrial protein FimA PF16970.5 KII60426.1 - 0.00082 19.6 0.3 0.14 12.4 0.0 2.2 2 0 0 2 2 2 2 Type-1 fimbrial protein, A Fimbrial PF00419.20 KII60427.1 - 3.4e-17 63.1 11.1 3.7e-17 63.0 11.1 1.0 1 0 0 1 1 1 1 Fimbrial protein FimA PF16970.5 KII60427.1 - 0.00014 22.0 11.9 0.005 17.0 11.9 2.0 1 1 0 1 1 1 1 Type-1 fimbrial protein, A Phage_integrase PF00589.22 KII60428.1 - 1.1e-43 149.0 0.2 1.3e-43 148.8 0.2 1.1 1 0 0 1 1 1 1 Phage integrase family DUF3435 PF11917.8 KII60428.1 - 0.1 11.5 0.8 0.87 8.4 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 KII60429.1 - 1.4e-49 168.2 0.1 2.5e-49 167.4 0.0 1.4 1 1 1 2 2 2 1 Phage integrase family DUF3265 PF11665.8 KII60430.1 - 0.5 10.6 2.3 0.9 9.8 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3265) Cmc1 PF08583.10 KII60431.1 - 0.015 15.3 2.6 0.034 14.1 2.6 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like RVT_1 PF00078.27 KII60433.1 - 4.3e-21 75.5 0.1 6e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII60434.1 - 5e-05 23.8 0.0 0.00012 22.6 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII60434.1 - 0.0034 18.0 0.2 0.01 16.5 0.1 1.8 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.20 KII60434.1 - 0.15 12.4 0.0 0.46 10.8 0.0 1.8 2 0 0 2 2 2 0 Retroviral aspartyl protease rve PF00665.26 KII60435.1 - 6.3e-07 29.6 0.1 1.2e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_1_2 PF13586.6 KII60435.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Transposase DDE domain DUF3850 PF12961.7 KII60435.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) rve_3 PF13683.6 KII60435.1 - 0.11 12.3 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain TPALS PF18178.1 KII60437.1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family Asp_protease_2 PF13650.6 KII60438.1 - 0.043 14.4 0.0 0.079 13.6 0.0 1.5 1 1 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 KII60438.1 - 0.089 13.4 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DNAP_B_exo_N PF08452.10 KII60438.1 - 0.17 11.3 0.4 0.39 10.2 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase family B exonuclease domain, N-terminal Sir1 PF11603.8 KII60440.1 - 0.0049 17.4 0.3 0.0076 16.7 0.3 1.3 1 0 0 1 1 1 1 Regulatory protein Sir1 Actin PF00022.19 KII60442.1 - 6.8e-13 48.0 0.0 9.3e-08 31.1 0.0 2.1 1 1 1 2 2 2 2 Actin zf-CCHC PF00098.23 KII60444.1 - 2.2e-06 27.4 10.7 1.4e-05 24.9 1.8 2.5 2 0 0 2 2 2 2 Zinc knuckle RVP_2 PF08284.11 KII60444.1 - 0.011 15.5 0.1 0.026 14.3 0.1 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII60444.1 - 0.015 15.8 0.1 0.037 14.6 0.1 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII60444.1 - 0.04 14.2 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 KII60444.1 - 0.056 13.2 7.1 1.6 8.5 0.5 2.5 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII60444.1 - 0.13 12.4 0.0 0.39 10.8 0.0 1.9 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_2 PF13696.6 KII60444.1 - 0.79 9.6 11.1 2.8 7.9 0.7 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 KII60444.1 - 2.5 8.1 8.5 1.4 9.0 0.7 2.6 1 1 1 2 2 2 0 Zinc knuckle Coatomer_WDAD PF04053.14 KII60445.1 - 1.4e-77 261.6 13.5 1e-62 212.7 3.5 3.6 2 1 1 3 3 3 2 Coatomer WD associated region WD40 PF00400.32 KII60445.1 - 5.8e-24 83.9 8.3 2.2e-05 25.1 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat BBS2_Mid PF14783.6 KII60445.1 - 0.018 15.0 0.0 12 6.0 0.0 3.4 2 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region VHS PF00790.19 KII60447.1 - 0.037 13.9 0.2 0.049 13.5 0.2 1.2 1 0 0 1 1 1 0 VHS domain AA_permease PF00324.21 KII60449.1 - 1.1e-31 109.9 11.5 1.3e-31 109.7 11.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KII60449.1 - 2.4e-10 39.8 13.3 2.8e-10 39.6 13.3 1.0 1 0 0 1 1 1 1 Amino acid permease RseC_MucC PF04246.12 KII60449.1 - 0.0026 17.7 2.9 0.098 12.6 1.1 2.2 2 0 0 2 2 2 2 Positive regulator of sigma(E), RseC/MucC DUF4131 PF13567.6 KII60449.1 - 0.11 12.2 0.3 0.11 12.2 0.3 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) AA_permease PF00324.21 KII60450.1 - 1.2e-70 238.5 24.9 1.5e-70 238.1 24.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KII60450.1 - 1.9e-21 76.4 24.1 2.2e-21 76.2 24.1 1.0 1 0 0 1 1 1 1 Amino acid permease LysR_substrate PF03466.20 KII60451.1 - 4.7e-26 91.5 0.0 6.4e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 KII60451.1 - 4.5e-19 68.1 1.7 8.4e-19 67.3 1.7 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 KII60451.1 - 0.0082 16.0 0.1 0.017 14.9 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 KII60451.1 - 0.034 14.0 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 KII60451.1 - 0.039 13.5 0.0 0.091 12.3 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Cys_Met_Meta_PP PF01053.20 KII60452.1 - 8.6e-94 314.2 0.0 1.1e-93 313.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme EamA PF00892.20 KII60453.1 - 1.4e-17 64.1 4.5 1.6e-17 63.9 4.5 1.0 1 0 0 1 1 1 1 EamA-like transporter family EamA PF00892.20 KII60454.1 - 1.5e-08 34.9 11.4 1.7e-08 34.7 11.4 1.0 1 0 0 1 1 1 1 EamA-like transporter family HigB_toxin PF09907.9 KII60455.1 - 8.1e-14 51.6 0.2 1.4e-13 50.9 0.2 1.3 1 0 0 1 1 1 1 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system Antirestrict PF03230.13 KII60456.1 - 8.5e-19 67.4 0.4 2.1e-17 62.9 0.0 2.1 1 1 1 2 2 2 1 Antirestriction protein TPR_22 PF18833.1 KII60456.1 - 0.16 12.1 0.0 0.49 10.6 0.0 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat SLT PF01464.20 KII60457.1 - 8.3e-14 51.2 0.0 9.5e-14 51.1 0.0 1.0 1 0 0 1 1 1 1 Transglycosylase SLT domain Tra_M PF05261.11 KII60458.1 - 1.3e-59 199.7 0.2 1.5e-59 199.4 0.2 1.0 1 0 0 1 1 1 1 TraM protein, DNA-binding DUF2785 PF10978.8 KII60459.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) TraL PF07178.11 KII60460.1 - 7.3e-33 112.9 1.7 8.2e-33 112.7 1.7 1.0 1 0 0 1 1 1 1 TraL protein SurA_N_3 PF13624.6 KII60460.1 - 0.15 11.8 0.3 0.21 11.3 0.3 1.1 1 0 0 1 1 1 0 SurA N-terminal domain TraE PF05309.11 KII60461.1 - 2.4e-58 196.5 0.1 2.6e-58 196.4 0.1 1.0 1 0 0 1 1 1 1 TraE protein MarC PF01914.17 KII60462.1 - 0.056 12.8 0.0 0.073 12.5 0.0 1.1 1 0 0 1 1 1 0 MarC family integral membrane protein DUF4191 PF13829.6 KII60462.1 - 0.087 12.1 0.2 0.095 12.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Ac76 PF05814.11 KII60462.1 - 0.11 12.5 0.7 0.16 12.0 0.7 1.2 1 0 0 1 1 1 0 Orf76 (Ac76) DUF2207 PF09972.9 KII60464.1 - 0.012 14.5 0.6 0.012 14.4 0.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Tetraspanin PF00335.20 KII60464.1 - 0.014 15.1 0.6 0.017 14.8 0.6 1.1 1 0 0 1 1 1 0 Tetraspanin family Presenilin PF01080.17 KII60464.1 - 0.024 13.4 2.4 0.03 13.1 2.4 1.1 1 0 0 1 1 1 0 Presenilin HlyIII PF03006.20 KII60464.1 - 0.025 14.3 1.0 0.034 13.9 1.0 1.1 1 0 0 1 1 1 0 Haemolysin-III related Wzy_C PF04932.15 KII60464.1 - 0.15 11.7 0.9 0.2 11.3 0.9 1.3 1 0 0 1 1 1 0 O-Antigen ligase DUF4212 PF13937.6 KII60464.1 - 0.37 11.2 3.2 0.66 10.4 3.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) rve PF00665.26 KII60467.1 - 6.3e-19 68.3 0.0 9.1e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60467.1 - 5.5e-10 39.2 0.1 1.3e-09 38.0 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII60467.1 - 0.011 15.9 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 H2C2 zinc finger DUF4420 PF14390.6 KII60467.1 - 0.16 11.2 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Putative PD-(D/E)XK family member, (DUF4420) Serpin PF00079.20 KII60468.1 - 3.4e-12 46.4 0.0 5e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ldl_recept_a PF00057.18 KII60471.1 - 3.7e-07 30.3 13.1 3.7e-07 30.3 13.1 2.9 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A DUF4024 PF13216.6 KII60471.1 - 5.3 7.1 6.0 12 6.0 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) ANTH PF07651.16 KII60474.1 - 5.5e-27 94.5 1.3 6.5e-27 94.2 1.3 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 KII60474.1 - 0.00056 20.0 0.0 0.0032 17.5 0.0 2.1 2 0 0 2 2 2 1 ENTH domain PurA PF04845.13 KII60476.1 - 0.00014 21.3 1.5 0.02 14.2 0.1 2.8 1 1 1 2 2 2 2 PurA ssDNA and RNA-binding protein NAGLU_N PF12971.7 KII60476.1 - 0.024 14.4 0.4 0.22 11.3 0.0 2.5 3 0 0 3 3 3 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain DUF3201 PF11447.8 KII60476.1 - 0.066 12.7 0.1 0.15 11.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3201) CHORD PF04968.12 KII60478.1 - 2e-30 105.3 13.2 9.5e-23 80.7 3.8 2.3 2 0 0 2 2 2 2 CHORD Vac14_Fab1_bd PF12755.7 KII60481.1 - 0.21 12.2 2.7 1.1 9.9 0.3 3.2 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Dimer_Tnp_hAT PF05699.14 KII60482.1 - 0.0014 18.4 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region MCM PF00493.23 KII60483.1 - 2.9e-60 203.1 0.0 5e-60 202.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 KII60483.1 - 4.4e-13 49.4 0.2 1.1e-12 48.2 0.2 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 KII60483.1 - 1.7e-11 44.0 1.0 4.5e-11 42.7 0.3 2.1 2 0 0 2 2 2 1 MCM OB domain AAA_5 PF07728.14 KII60483.1 - 2.2e-05 24.5 0.0 6.2e-05 23.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KII60483.1 - 0.00077 19.9 0.4 0.0019 18.6 0.2 1.7 2 0 0 2 2 1 1 AAA ATPase domain AAA PF00004.29 KII60483.1 - 0.002 18.5 0.0 0.011 16.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KII60483.1 - 0.0063 15.9 0.2 0.15 11.4 0.0 2.6 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 KII60483.1 - 0.0091 15.5 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 KII60483.1 - 0.0098 16.0 0.8 0.024 14.7 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase Phage_Treg PF04761.12 KII60483.1 - 0.021 14.9 0.1 13 6.0 0.1 2.7 2 0 0 2 2 2 0 Lactococcus bacteriophage putative transcription regulator DUF3361 PF11841.8 KII60483.1 - 0.027 14.4 0.4 0.061 13.3 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) Viral_helicase1 PF01443.18 KII60483.1 - 0.042 13.6 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 KII60483.1 - 0.048 14.1 0.0 0.16 12.4 0.0 2.0 1 1 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 KII60483.1 - 0.057 13.7 0.9 0.2 11.9 0.2 2.2 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 KII60483.1 - 0.06 12.5 0.1 0.16 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.13 KII60483.1 - 0.082 13.1 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 KII60483.1 - 0.099 13.2 1.4 0.19 12.2 0.1 2.1 2 1 0 2 2 2 0 ABC transporter Zeta_toxin PF06414.12 KII60483.1 - 0.11 11.7 0.0 0.32 10.2 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 KII60483.1 - 0.13 12.2 0.3 0.87 9.5 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 KII60483.1 - 0.48 10.7 3.5 0.33 11.3 0.2 2.1 2 0 0 2 2 2 0 AAA domain RVP_2 PF08284.11 KII60487.1 - 0.024 14.4 1.1 0.03 14.1 0.3 1.6 1 1 1 2 2 2 0 Retroviral aspartyl protease RT_RNaseH_2 PF17919.1 KII60489.1 - 5.7e-34 116.1 0.0 1.4e-33 114.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60489.1 - 1.8e-32 111.8 0.0 5.4e-32 110.2 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII60489.1 - 6e-21 75.0 0.0 1.2e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII60489.1 - 7.7e-20 71.3 0.0 3.6e-19 69.1 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60489.1 - 1.7e-17 63.2 0.0 4.5e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII60489.1 - 1.2e-06 29.0 0.0 2.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII60489.1 - 5.2e-05 23.8 0.0 0.00013 22.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII60489.1 - 0.00054 20.2 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.6 KII60489.1 - 0.0092 15.7 0.0 0.033 14.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain HypF_C PF17788.1 KII60489.1 - 0.13 13.0 0.0 1.2 9.8 0.0 2.4 2 0 0 2 2 2 0 HypF Kae1-like domain BNR PF02012.20 KII60490.1 - 0.041 13.9 0.2 0.082 13.0 0.2 1.5 1 0 0 1 1 1 0 BNR/Asp-box repeat MULE PF10551.9 KII60494.1 - 6.8e-16 58.5 0.5 1.3e-15 57.5 0.5 1.5 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.16 KII60494.1 - 5.1 7.3 7.3 0.53 10.4 2.1 2.2 2 0 0 2 2 2 0 FLYWCH zinc finger domain PI31_Prot_N PF11566.8 KII60497.1 - 0.05 13.4 0.1 0.11 12.3 0.0 1.6 1 1 1 2 2 2 0 PI31 proteasome regulator N-terminal Pro_sub2 PF18513.1 KII60498.1 - 0.013 15.6 0.5 0.03 14.5 0.4 1.7 1 1 1 2 2 2 0 Prodomain subtilisin 2 Tetraspanin PF00335.20 KII60500.1 - 5.9e-13 49.1 7.7 7.5e-13 48.7 7.7 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF4134 PF13572.6 KII60500.1 - 0.067 13.5 1.2 0.067 13.5 1.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4134) Cadherin_C_2 PF16492.5 KII60500.1 - 7.8 7.3 9.7 18 6.1 3.4 2.4 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal Sortilin_C PF15901.5 KII60501.1 - 2.6e-18 66.9 5.1 2.6e-18 66.9 5.1 2.1 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII60501.1 - 1.2e-12 47.4 0.4 8e-08 31.5 0.0 3.9 2 2 0 2 2 2 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII60501.1 - 2e-07 31.1 10.8 2e-07 31.1 10.8 4.3 3 1 1 4 4 4 1 Low-density lipoprotein receptor domain class A BNR_6 PF15899.5 KII60501.1 - 0.0061 16.5 2.4 0.24 11.6 0.2 3.2 2 0 0 2 2 2 1 BNR-Asp box repeat BNR PF02012.20 KII60501.1 - 0.032 14.2 7.8 19 5.8 0.0 5.5 5 0 0 5 5 5 0 BNR/Asp-box repeat Serpin PF00079.20 KII60502.1 - 5.6e-53 180.6 2.3 6.3e-53 180.4 2.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Phenol_Hydrox PF02332.18 KII60502.1 - 0.0077 15.8 0.5 0.016 14.7 0.5 1.5 1 0 0 1 1 1 1 Methane/Phenol/Toluene Hydroxylase DUF4052 PF13261.6 KII60502.1 - 0.053 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4052) PFO_beta_C PF12367.8 KII60502.1 - 0.091 12.9 0.8 0.25 11.5 0.8 1.8 1 0 0 1 1 1 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal Sortilin_C PF15901.5 KII60504.1 - 4.5e-12 46.6 0.2 8.7e-12 45.7 0.2 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII60504.1 - 3.7e-05 22.7 0.2 0.14 10.9 0.0 2.3 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Use1 PF09753.9 KII60506.1 - 4.1e-14 52.9 9.8 3e-13 50.1 9.8 1.9 1 1 0 1 1 1 1 Membrane fusion protein Use1 DUF3313 PF11769.8 KII60506.1 - 0.053 13.3 0.2 0.087 12.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) MtmB PF05369.12 KII60506.1 - 0.13 11.1 0.2 0.18 10.6 0.2 1.2 1 0 0 1 1 1 0 Monomethylamine methyltransferase MtmB Fig1 PF12351.8 KII60506.1 - 0.7 9.8 2.5 1.1 9.1 1.9 1.6 1 1 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Topo-VIb_trans PF09239.11 KII60507.1 - 0.03 14.2 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 Topoisomerase VI B subunit, transducer DDE_Tnp_IS1595 PF12762.7 KII60508.1 - 5e-07 29.9 0.0 7.2e-06 26.1 0.0 2.0 1 1 1 2 2 2 2 ISXO2-like transposase domain Voldacs PF03517.13 KII60509.1 - 0.03 14.4 0.1 1.5 8.9 0.0 2.2 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling rve PF00665.26 KII60511.1 - 3.8e-17 62.6 0.0 4.9e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII60511.1 - 0.0053 16.5 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60513.1 - 5.4e-10 39.2 1.4 8.1e-10 38.7 1.4 1.2 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII60514.1 - 5.7e-15 55.4 0.5 4.2e-14 52.6 0.1 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) FAD_binding_8 PF08022.12 KII60518.1 - 0.059 13.5 0.3 0.25 11.4 0.0 1.9 1 1 1 2 2 2 0 FAD-binding domain RT_RNaseH PF17917.1 KII60519.1 - 1.2e-11 44.8 0.4 2.5e-11 43.8 0.2 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII60519.1 - 0.044 13.9 0.0 0.072 13.2 0.0 1.4 1 0 0 1 1 1 0 Integrase zinc binding domain DUF1495 PF07381.11 KII60523.1 - 0.14 12.0 0.1 0.33 10.8 0.1 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) MLVIN_C PF18697.1 KII60524.1 - 0.00071 19.6 0.0 0.0011 19.1 0.0 1.3 1 1 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RT_RNaseH_2 PF17919.1 KII60525.1 - 6e-31 106.4 0.0 1.3e-30 105.4 0.0 1.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60525.1 - 1.3e-26 92.9 0.0 2.3e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII60525.1 - 1.2e-08 34.8 0.0 2.1e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Methyltr_RsmB-F PF01189.17 KII60526.1 - 0.042 13.5 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F BLM10_mid PF16507.5 KII60526.1 - 0.12 11.0 0.1 0.17 10.5 0.1 1.1 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region DUF5527 PF17665.1 KII60527.1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5527) PsbT PF01405.17 KII60527.1 - 0.95 9.3 3.6 1.9 8.4 3.6 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre T protein DUF5527 PF17665.1 KII60529.1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5527) PsbT PF01405.17 KII60529.1 - 0.95 9.3 3.6 1.9 8.4 3.6 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre T protein Bcr-Abl_Oligo PF09036.10 KII60532.1 - 0.022 14.8 0.1 0.95 9.5 0.0 2.3 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain CHDCT2 PF08074.11 KII60533.1 - 0.016 15.4 0.0 0.016 15.4 0.0 1.1 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain DUF1098 PF06497.11 KII60533.1 - 0.12 12.9 0.1 0.48 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1098) DUF1759 PF03564.15 KII60534.1 - 0.09 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) EGF_2 PF07974.13 KII60536.1 - 0.015 15.7 2.9 0.036 14.4 2.9 1.7 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 KII60536.1 - 0.049 13.8 1.1 0.09 12.9 1.1 1.4 1 0 0 1 1 1 0 Laminin EGF domain hEGF PF12661.7 KII60538.1 - 9.6 7.0 8.2 1.3 9.8 1.9 2.7 3 0 0 3 3 3 0 Human growth factor-like EGF EGF PF00008.27 KII60540.1 - 0.031 14.6 1.2 0.066 13.5 1.2 1.6 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.13 KII60540.1 - 0.18 12.2 5.3 0.43 11.0 5.3 1.7 1 1 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.24 KII60540.1 - 0.32 11.2 3.3 0.39 10.9 2.6 1.6 1 1 0 1 1 1 0 Laminin EGF domain Methyltransf_31 PF13847.6 KII60541.1 - 0.017 14.9 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain TLP-20 PF06088.11 KII60543.1 - 0.036 13.9 1.2 0.048 13.6 1.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Lipocalin PF00061.23 KII60543.1 - 0.078 13.2 1.8 0.12 12.6 1.8 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Endonuc_subdom PF09062.10 KII60546.1 - 0.014 16.2 0.5 0.024 15.4 0.5 1.4 1 0 0 1 1 1 0 PI-PfuI Endonuclease subdomain Flu_NS2 PF00601.19 KII60547.1 - 0.16 12.3 1.0 0.38 11.1 0.0 2.2 3 0 0 3 3 3 0 Influenza non-structural protein (NS2) End_beta_barrel PF12195.8 KII60547.1 - 2.5 8.1 13.0 4.7 7.2 2.1 3.7 2 2 1 3 3 3 0 Beta barrel domain of bacteriophage endosialidase Plasmod_dom_1 PF09715.10 KII60547.1 - 2.6 8.2 6.2 4.5 7.4 0.1 3.6 4 0 0 4 4 4 0 Plasmodium protein of unknown function (Plasmod_dom_1) Pox_EPC_I2-L1 PF12575.8 KII60548.1 - 0.88 9.8 4.3 0.32 11.2 0.5 2.3 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 C9orf72-like PF15019.6 KII60549.1 - 0.073 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 C9orf72-like protein family Ldl_recept_a PF00057.18 KII60550.1 - 6.8e-07 29.4 11.0 6.8e-07 29.4 11.0 3.9 3 1 1 4 4 4 1 Low-density lipoprotein receptor domain class A NUP214 PF16755.5 KII60550.1 - 0.012 14.8 0.8 0.019 14.2 0.8 1.3 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 FG-GAP PF01839.23 KII60551.1 - 1.7e-07 31.2 9.0 0.0083 16.2 6.2 2.4 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.6 KII60551.1 - 8.6e-07 29.5 2.3 1.3e-06 28.9 0.1 2.5 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EamA PF00892.20 KII60552.1 - 7.7e-14 52.0 38.3 5.6e-08 33.0 14.5 2.8 1 1 2 3 3 3 2 EamA-like transporter family EmrE PF13536.6 KII60552.1 - 0.0028 17.3 6.1 0.0028 17.3 6.1 2.6 2 1 1 3 3 3 1 Putative multidrug resistance efflux transporter CAF1A PF12253.8 KII60553.1 - 1.7e-24 85.8 3.5 3.9e-24 84.6 3.5 1.6 1 0 0 1 1 1 1 Chromatin assembly factor 1 subunit A CENP-K PF11802.8 KII60553.1 - 0.0049 16.5 0.2 0.0049 16.5 0.2 1.6 2 0 0 2 2 2 1 Centromere-associated protein K GNT-I PF03071.15 KII60555.1 - 4.3e-32 111.4 0.9 1.2e-31 110.0 0.9 1.6 1 1 0 1 1 1 1 GNT-I family MGAT2 PF05060.14 KII60555.1 - 2.5e-09 36.7 1.5 7.2e-05 22.0 0.2 2.2 2 0 0 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) Glyco_transf_25 PF01755.17 KII60555.1 - 2.6e-05 24.2 0.7 4.3e-05 23.5 0.7 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_3 PF13641.6 KII60555.1 - 0.17 11.8 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 EF-hand_like PF09279.11 KII60558.1 - 0.073 13.6 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like RVT_1 PF00078.27 KII60559.1 - 1.9e-13 50.5 0.1 2.5e-13 50.1 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII60562.1 - 8e-12 45.1 0.0 1.5e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60562.1 - 0.0016 18.7 0.0 0.003 17.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII60563.1 - 2.3e-09 37.2 0.0 4.5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60563.1 - 4.9e-09 36.4 0.0 9.5e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII60564.1 - 0.017 15.3 0.4 1.8 8.8 0.2 2.6 1 1 1 2 2 2 0 Integrase core domain DDE_1 PF03184.19 KII60565.1 - 3.8e-08 33.2 0.4 1.1e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII60565.1 - 0.0053 16.7 1.1 0.0053 16.7 1.1 1.6 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain MFS_1 PF07690.16 KII60566.1 - 8.3e-47 159.8 43.3 8.3e-47 159.8 43.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily ABC_tran PF00005.27 KII60566.1 - 1.5e-16 61.2 0.0 1.9e-09 38.2 0.0 3.8 3 1 0 3 3 3 3 ABC transporter MFS_2 PF13347.6 KII60566.1 - 1.2e-09 37.3 26.0 0.0001 21.0 0.1 2.4 2 1 0 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.24 KII60566.1 - 2e-09 36.9 3.9 2e-09 36.9 3.9 2.3 1 1 0 2 2 2 1 Sugar (and other) transporter UvrA_DNA-bind PF17755.1 KII60566.1 - 6.7e-08 32.9 0.0 1.2e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 UvrA DNA-binding domain AAA_16 PF13191.6 KII60566.1 - 1.1e-06 29.1 0.0 0.023 15.1 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 KII60566.1 - 2.2e-06 27.7 11.5 0.00013 21.8 0.1 3.5 4 0 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KII60566.1 - 9.1e-06 25.3 0.2 0.055 13.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 KII60566.1 - 6.9e-05 22.4 0.1 1.2 8.5 0.0 3.9 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain DnaJ_CXXCXGXG PF00684.19 KII60566.1 - 7.6e-05 23.0 3.0 0.0057 17.0 0.1 3.3 3 0 0 3 3 3 1 DnaJ central domain MFS_3 PF05977.13 KII60566.1 - 0.0009 17.7 22.3 0.0013 17.2 22.3 1.1 1 0 0 1 1 1 1 Transmembrane secretion effector AAA_15 PF13175.6 KII60566.1 - 0.0022 17.8 2.0 0.12 12.0 0.0 3.3 4 0 0 4 4 4 1 AAA ATPase domain Anti-TRAP PF15777.5 KII60566.1 - 0.0023 17.8 2.5 0.57 10.2 0.9 3.7 3 1 0 3 3 3 1 Tryptophan RNA-binding attenuator protein inhibitory protein RsgA_GTPase PF03193.16 KII60566.1 - 0.0024 17.8 0.1 0.049 13.5 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 KII60566.1 - 0.0066 16.6 0.3 1.1 9.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain MFS_4 PF06779.14 KII60566.1 - 0.016 14.5 26.6 0.028 13.7 26.6 1.3 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB Viral_helicase1 PF01443.18 KII60566.1 - 0.074 12.8 0.0 3 7.5 0.1 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 KII60566.1 - 0.085 12.8 0.2 11 5.9 0.2 2.4 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 KII60566.1 - 0.15 11.7 0.3 15 5.2 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KII60566.1 - 0.17 12.1 0.0 27 5.0 0.0 3.3 4 0 0 4 4 3 0 AAA domain RNA12 PF10443.9 KII60566.1 - 0.19 10.4 0.1 3.6 6.2 0.0 2.1 2 0 0 2 2 2 0 RNA12 protein cobW PF02492.19 KII60566.1 - 0.2 11.3 0.3 4.2 6.9 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain HpaB_N PF11794.8 KII60567.1 - 1.3e-89 300.5 0.0 1.7e-89 300.1 0.0 1.1 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal HpaB PF03241.13 KII60567.1 - 3.8e-68 228.5 0.0 5.1e-68 228.2 0.0 1.1 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase C terminal Chorismate_bind PF00425.18 KII60568.1 - 6.3e-44 150.5 0.0 8.6e-44 150.0 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 KII60568.1 - 2.2e-19 70.0 0.0 3.4e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 KII60568.1 - 0.0093 15.8 0.0 0.022 14.6 0.0 1.6 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 KII60568.1 - 0.016 15.0 0.1 0.032 14.0 0.1 1.4 1 0 0 1 1 1 0 Peptidase C26 Isochorismatase PF00857.20 KII60569.1 - 7e-36 124.0 0.0 7.9e-36 123.8 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family DAHP_synth_2 PF01474.16 KII60570.1 - 3.2e-106 355.5 0.0 1.8e-60 204.7 0.0 2.1 1 1 1 2 2 2 2 Class-II DAHP synthetase family adh_short PF00106.25 KII60570.1 - 1.8e-55 187.5 1.6 2.6e-55 186.9 1.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII60570.1 - 3.6e-51 174.0 3.1 5.1e-51 173.5 3.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII60570.1 - 1.1e-12 48.2 2.4 2.1e-12 47.3 2.4 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KII60570.1 - 0.0034 16.9 0.6 0.0074 15.8 0.6 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KII60570.1 - 0.0058 15.8 0.3 0.0086 15.2 0.3 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF2478 PF10649.9 KII60570.1 - 0.0075 15.9 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2478) Sacchrp_dh_NADP PF03435.18 KII60570.1 - 0.0087 16.3 0.1 0.021 15.1 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 KII60570.1 - 0.035 13.5 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Ldh_1_N PF00056.23 KII60570.1 - 0.051 13.7 0.2 0.18 11.9 0.1 1.9 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 KII60570.1 - 0.14 12.0 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AMP-binding PF00501.28 KII60571.1 - 2.4e-48 164.8 0.0 3.1e-48 164.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KII60571.1 - 1.8e-06 28.8 0.0 3.5e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 KII60571.1 - 0.098 11.5 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 GH3 auxin-responsive promoter Herpes_UL24 PF01646.16 KII60571.1 - 0.13 12.3 0.1 0.5 10.3 0.0 1.8 2 0 0 2 2 2 0 Herpes virus proteins UL24 and UL76 AMP-binding PF00501.28 KII60572.1 - 1.6e-73 247.8 0.0 2.3e-73 247.2 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 KII60572.1 - 9.6e-50 169.6 0.0 3.9e-28 98.3 0.0 2.1 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 KII60572.1 - 3.6e-13 49.7 0.1 1.3e-12 47.9 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 KII60572.1 - 4.1e-12 46.9 0.0 1.1e-11 45.5 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_4 PF07993.12 KII60572.1 - 1.1e-10 41.1 0.0 1.9e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 KII60572.1 - 0.025 14.1 0.0 0.092 12.2 0.0 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family KR PF08659.10 KII60572.1 - 0.16 11.8 0.1 0.44 10.4 0.1 1.7 1 0 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 KII60572.1 - 0.2 11.0 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Ribosomal_60s PF00428.19 KII60575.1 - 1.5e-17 64.0 6.5 1.7e-17 63.8 6.5 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Borrelia_REV PF03978.13 KII60575.1 - 0.054 13.5 0.1 0.065 13.2 0.1 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein Peptidase_C6 PF00851.18 KII60576.1 - 0.072 12.0 0.1 0.081 11.8 0.1 1.1 1 0 0 1 1 1 0 Helper component proteinase Retrotran_gag_3 PF14244.6 KII60577.1 - 0.057 13.2 2.1 7.2 6.5 0.1 2.3 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type Hrs_helical PF12210.8 KII60578.1 - 0.13 12.8 0.2 0.21 12.1 0.2 1.3 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate HSP20 PF00011.21 KII60579.1 - 1.2e-25 89.5 0.9 1.5e-13 50.8 0.2 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII60579.1 - 0.01 15.3 0.1 3.2 7.4 0.0 2.3 2 0 0 2 2 2 0 HSP20-like domain found in ArsA HSP20 PF00011.21 KII60580.1 - 3.8e-25 88.0 0.7 4.7e-15 55.6 0.3 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII60580.1 - 0.00092 18.7 0.1 0.14 11.7 0.1 2.5 2 1 0 2 2 2 2 HSP20-like domain found in ArsA Vfa1 PF08432.10 KII60581.1 - 0.11 12.8 13.5 0.027 14.8 10.2 1.6 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4207 PF13904.6 KII60581.1 - 0.13 11.9 16.3 0.17 11.5 16.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) AAA_11 PF13086.6 KII60581.1 - 1.1 9.0 11.7 1.4 8.6 11.7 1.2 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 KII60582.1 - 6.6e-08 32.5 0.0 8.3e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD PF00270.29 KII60583.1 - 0.065 13.0 0.0 0.09 12.5 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase SPC22 PF04573.12 KII60584.1 - 3.8e-30 104.6 0.3 4.7e-30 104.3 0.3 1.1 1 0 0 1 1 1 1 Signal peptidase subunit Homeobox_KN PF05920.11 KII60585.1 - 2.1e-14 53.1 0.2 4.5e-14 52.1 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KII60585.1 - 3.9e-10 39.4 0.8 6.8e-10 38.7 0.8 1.4 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 KII60585.1 - 0.041 13.3 0.0 0.08 12.4 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez SNARE PF05739.19 KII60586.1 - 0.013 15.5 0.4 0.5 10.4 0.1 2.8 3 0 0 3 3 3 0 SNARE domain zf-C3HC4_3 PF13920.6 KII60587.1 - 5.6e-12 45.3 5.0 8.7e-12 44.7 5.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KII60587.1 - 9.3e-12 44.6 5.4 1.3e-11 44.1 5.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KII60587.1 - 1.7e-10 40.8 3.2 1.7e-10 40.8 3.2 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KII60587.1 - 5.5e-10 39.1 4.9 7.9e-10 38.5 4.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KII60587.1 - 7e-10 39.1 8.0 1.1e-09 38.5 8.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KII60587.1 - 9.1e-10 38.2 7.8 1.4e-09 37.6 7.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII60587.1 - 4.5e-09 36.0 7.0 6.8e-09 35.4 7.0 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KII60587.1 - 5.2e-06 26.5 7.4 7.9e-06 25.9 7.4 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 KII60587.1 - 5.6e-05 23.3 8.8 0.00017 21.8 8.8 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.15 KII60587.1 - 7.9e-05 22.7 0.0 0.00023 21.3 0.0 1.7 2 0 0 2 2 2 1 U-box domain Rtf2 PF04641.12 KII60587.1 - 0.0046 16.3 0.1 0.0055 16.1 0.1 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-ANAPC11 PF12861.7 KII60587.1 - 0.011 15.7 5.9 0.026 14.6 6.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 KII60587.1 - 0.06 13.2 3.8 0.19 11.6 4.0 1.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 KII60587.1 - 0.087 12.6 5.1 0.19 11.6 5.1 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 KII60587.1 - 0.11 12.3 2.8 0.18 11.6 2.8 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 KII60587.1 - 0.17 12.0 2.9 0.26 11.5 2.9 1.2 1 0 0 1 1 1 0 zinc RING finger of MSL2 GAGA PF09237.11 KII60587.1 - 0.19 11.5 0.7 4.8 7.1 0.1 2.2 2 0 0 2 2 2 0 GAGA factor Zn_ribbon_17 PF17120.5 KII60587.1 - 0.44 10.2 8.0 0.16 11.6 4.4 1.8 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KII60587.1 - 0.98 9.2 7.0 0.18 11.6 2.3 2.2 1 1 1 2 2 2 0 RING-like zinc finger Baculo_IE-1 PF05290.11 KII60587.1 - 1.1 9.3 4.6 1.6 8.7 4.6 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) IBR PF01485.21 KII60587.1 - 1.4 9.2 8.2 8.5 6.7 7.9 2.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain RVT_1 PF00078.27 KII60591.1 - 0.0004 20.0 0.1 0.0013 18.3 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2115 PF09888.9 KII60591.1 - 0.03 14.9 1.2 6.6 7.2 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2115) RAB3GAP2_C PF14656.6 KII60591.1 - 0.088 11.0 0.0 0.15 10.3 0.0 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus CCDC-167 PF15188.6 KII60591.1 - 0.22 11.9 1.7 1.2 9.5 0.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 PC_rep PF01851.22 KII60593.1 - 3.6e-08 33.4 0.5 0.13 12.8 0.0 4.2 4 0 0 4 4 4 3 Proteasome/cyclosome repeat RPN2_C PF18004.1 KII60594.1 - 2.1e-09 37.5 0.1 2.9e-09 37.0 0.1 1.2 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain Erv26 PF04148.13 KII60594.1 - 0.49 10.2 3.0 0.62 9.9 2.4 1.4 1 1 0 1 1 1 0 Transmembrane adaptor Erv26 RPN2_C PF18004.1 KII60595.1 - 1.7e-05 24.8 0.1 1.7e-05 24.8 0.1 2.0 1 1 1 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain Sec23_trunk PF04811.15 KII60596.1 - 4.4e-42 144.3 0.3 7.2e-42 143.6 0.3 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 KII60596.1 - 1.9e-15 56.6 8.6 5e-15 55.3 8.6 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 KII60596.1 - 8e-15 54.5 0.1 2e-14 53.3 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KII60596.1 - 3.8e-14 53.2 0.3 1.5e-13 51.2 0.3 2.2 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 KII60596.1 - 4.1e-08 33.0 0.0 1e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat HAP2-GCS1 PF10699.9 KII60597.1 - 2.8e-14 52.8 0.1 5.9e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 Male gamete fusion factor DUF1281_C PF18406.1 KII60597.1 - 0.062 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Ferredoxin-like domain in Api92-like protein PQQ_3 PF13570.6 KII60598.1 - 0.021 15.3 0.4 0.19 12.2 0.0 2.5 2 0 0 2 2 2 0 PQQ-like domain LEAP-2 PF07359.11 KII60599.1 - 0.021 14.6 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) HisG_C PF08029.11 KII60599.1 - 0.17 12.1 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 HisG, C-terminal domain Methyltransf_4 PF02390.17 KII60600.1 - 8.1e-42 142.6 0.1 9.2e-42 142.4 0.1 1.0 1 0 0 1 1 1 1 Putative methyltransferase Tmpp129 PF10272.9 KII60600.1 - 0.085 12.1 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Putative transmembrane protein precursor Vwaint PF14624.6 KII60600.1 - 0.18 12.0 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 VWA / Hh protein intein-like Pox_MCEL PF03291.16 KII60601.1 - 0.048 12.8 0.1 0.09 11.9 0.0 1.5 1 1 1 2 2 2 0 mRNA capping enzyme Methyltransf_23 PF13489.6 KII60601.1 - 0.1 12.4 0.2 0.24 11.2 0.2 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KII60601.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.25 KII60602.1 - 5.1e-17 62.1 0.0 6.8e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII60602.1 - 5.4e-06 25.9 0.0 2.9e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase DDE_3 PF13358.6 KII60603.1 - 1.1e-12 48.0 0.4 1.2e-12 47.8 0.4 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.7 KII60606.1 - 6.4e-07 29.5 0.1 2.6e-06 27.5 0.0 2.1 3 0 0 3 3 3 1 ISXO2-like transposase domain MG3 PF17791.1 KII60606.1 - 0.055 13.7 0.0 16 5.8 0.0 2.3 2 0 0 2 2 2 0 Macroglobulin domain MG3 OCC1 PF15506.6 KII60606.1 - 0.091 12.9 0.1 14 5.9 0.0 2.4 2 0 0 2 2 2 0 OCC1 family GRAM PF02893.20 KII60607.1 - 0.0007 19.5 1.1 0.011 15.6 1.0 2.4 1 1 0 1 1 1 1 GRAM domain DUF2661 PF10860.8 KII60607.1 - 0.19 11.9 3.7 0.085 13.0 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2661) Serpin PF00079.20 KII60609.1 - 6.1e-42 144.3 6.1 7.1e-42 144.0 6.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.26 KII60610.1 - 0.00072 19.7 0.0 0.0016 18.7 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII60610.1 - 0.0022 17.7 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2_5 PF13909.6 KII60610.1 - 0.062 13.1 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Integrase_H2C2 PF17921.1 KII60611.1 - 5.1e-12 45.7 0.3 1.2e-11 44.6 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain F-box_4 PF15966.5 KII60611.1 - 0.093 12.6 0.2 0.21 11.4 0.2 1.5 1 0 0 1 1 1 0 F-box CoxIIa PF08113.11 KII60612.1 - 0.08 12.8 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family DUF1348 PF07080.11 KII60613.1 - 0.045 13.7 0.1 0.052 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1348) Integrase_H2C2 PF17921.1 KII60616.1 - 8.5e-15 54.6 0.5 1.4e-14 53.9 0.5 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII60616.1 - 6.7e-09 36.0 0.0 9.5e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII60616.1 - 0.0052 17.0 0.2 0.011 16.0 0.2 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH PF17917.1 KII60618.1 - 7.4e-33 113.0 0.2 1.3e-31 109.0 0.0 2.4 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII60618.1 - 1.3e-26 92.5 0.5 3.5e-26 91.2 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII60618.1 - 1.5e-22 80.1 0.0 3.1e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60618.1 - 2.1e-18 66.1 1.4 3.7e-18 65.4 0.5 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain DDE_Tnp_IS240 PF13610.6 KII60618.1 - 0.0012 19.1 0.2 0.019 15.2 0.0 2.7 3 0 0 3 3 3 1 DDE domain rve_3 PF13683.6 KII60618.1 - 0.0043 16.8 0.2 0.018 14.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII60618.1 - 0.012 15.8 0.2 0.081 13.2 0.0 2.5 2 0 0 2 2 2 0 H2C2 zinc finger Serpin PF00079.20 KII60626.1 - 4.4e-37 128.2 0.9 5.1e-37 128.1 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Oxidored_q2 PF00420.24 KII60627.1 - 0.039 13.6 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L RAB3GAP2_C PF14656.6 KII60628.1 - 0.018 13.3 0.7 0.022 13.0 0.7 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Oxidored_q2 PF00420.24 KII60629.1 - 0.025 14.2 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L LacI PF00356.21 KII60631.1 - 0.021 14.6 0.0 0.045 13.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Hormone_6 PF00236.18 KII60631.1 - 0.03 14.3 1.5 0.035 14.1 0.6 1.6 1 1 1 2 2 2 0 Glycoprotein hormone Peptidase_S10 PF00450.22 KII60631.1 - 0.11 11.9 0.2 0.12 11.7 0.2 1.0 1 0 0 1 1 1 0 Serine carboxypeptidase RT_RNaseH_2 PF17919.1 KII60632.1 - 1.6e-35 121.1 0.2 3e-34 117.1 0.0 3.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60632.1 - 1.6e-34 118.3 0.0 2.4e-33 114.5 0.0 2.7 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII60632.1 - 2.1e-21 76.5 0.1 8.2e-21 74.5 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII60632.1 - 2.3e-20 72.9 0.0 6.7e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60632.1 - 4.2e-18 65.2 0.1 9e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII60632.1 - 1.3e-06 28.1 0.2 3.4e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII60632.1 - 0.0077 16.4 0.2 0.025 14.8 0.0 2.0 2 0 0 2 2 2 1 H2C2 zinc finger RICH PF05062.12 KII60632.1 - 0.23 11.8 3.8 1.1 9.7 1.6 2.6 2 0 0 2 2 2 0 RICH domain SecA_SW PF07516.13 KII60633.1 - 0.0073 16.4 0.4 0.023 14.7 0.3 1.9 2 0 0 2 2 2 1 SecA Wing and Scaffold domain DLP_helical PF18709.1 KII60633.1 - 0.019 14.2 0.9 0.029 13.6 0.9 1.3 1 0 0 1 1 1 0 Dynamin-like helical domain DUF4085 PF13315.6 KII60633.1 - 0.029 14.0 2.4 0.048 13.3 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Phage_HK97_TLTM PF06120.11 KII60633.1 - 0.037 13.2 2.9 0.057 12.6 2.9 1.3 1 0 0 1 1 1 0 Tail length tape measure protein rve PF00665.26 KII60635.1 - 0.0067 16.6 0.0 0.01 16.0 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain HVSL PF09749.9 KII60638.1 - 0.12 11.8 0.2 0.15 11.5 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein His_Phos_2 PF00328.22 KII60639.1 - 1.3e-17 64.3 1.5 1.8e-17 63.8 1.5 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Ribosomal_S13 PF00416.22 KII60640.1 - 0.12 12.8 0.1 0.16 12.3 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein S13/S18 DUF5089 PF17002.5 KII60641.1 - 5.5e-05 23.1 10.2 0.0066 16.3 1.8 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF5089) CASP_C PF08172.12 KII60641.1 - 0.012 15.0 1.5 0.017 14.5 1.4 1.3 1 1 0 1 1 1 0 CASP C terminal SlyX PF04102.12 KII60641.1 - 0.015 15.9 7.4 0.3 11.7 0.3 2.9 2 2 0 2 2 2 0 SlyX Laminin_II PF06009.12 KII60641.1 - 0.017 15.2 2.6 0.17 11.9 0.1 2.1 2 0 0 2 2 2 0 Laminin Domain II RPW8 PF05659.11 KII60641.1 - 0.037 13.7 1.8 1.4 8.6 0.4 2.1 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF713 PF05218.14 KII60641.1 - 0.051 13.3 4.2 0.41 10.4 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF713) WXG100 PF06013.12 KII60641.1 - 0.067 13.4 2.5 0.67 10.2 0.1 2.9 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Tropomyosin PF00261.20 KII60641.1 - 0.093 12.1 6.6 1.9 7.8 1.8 2.1 2 0 0 2 2 2 0 Tropomyosin GerE PF00196.19 KII60641.1 - 0.094 12.3 0.6 7.7 6.1 0.3 3.0 2 1 0 2 2 2 0 Bacterial regulatory proteins, luxR family DUF948 PF06103.11 KII60641.1 - 0.22 11.8 2.5 1.1 9.5 0.2 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec20 PF03908.13 KII60641.1 - 0.25 11.3 10.4 1.4 8.9 3.2 2.4 2 1 0 2 2 2 0 Sec20 DUF745 PF05335.13 KII60641.1 - 0.28 10.9 2.6 1.2 8.9 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF4200 PF13863.6 KII60641.1 - 0.61 10.5 7.0 6.6 7.2 1.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) NPV_P10 PF05531.12 KII60641.1 - 0.92 10.0 6.2 3.1 8.3 0.8 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 KII60641.1 - 0.95 9.5 4.8 1.3 9.1 0.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) V-SNARE_C PF12352.8 KII60641.1 - 1.2 9.5 12.0 0.99 9.7 3.6 2.3 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Fusion_gly PF00523.18 KII60641.1 - 1.2 7.3 4.9 0.24 9.6 0.6 1.8 2 0 0 2 2 2 0 Fusion glycoprotein F0 Fib_alpha PF08702.10 KII60641.1 - 2.8 8.1 7.5 10 6.3 0.6 2.3 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 KII60641.1 - 3.8 6.7 7.4 7.3 5.7 0.7 2.0 2 0 0 2 2 2 0 TMPIT-like protein Rx_N PF18052.1 KII60642.1 - 0.061 13.6 0.3 0.092 13.0 0.3 1.3 1 0 0 1 1 1 0 Rx N-terminal domain LCAT PF02450.15 KII60645.1 - 4.2e-14 52.5 0.0 4.7e-14 52.4 0.0 1.0 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF3437 PF11919.8 KII60645.1 - 0.067 13.1 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3437) adh_short PF00106.25 KII60647.1 - 1.1e-31 109.8 0.0 1.6e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII60647.1 - 1.8e-21 76.8 0.0 2.8e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII60647.1 - 6e-05 23.0 0.0 0.00013 21.9 0.0 1.6 2 0 0 2 2 2 1 KR domain AdoHcyase_NAD PF00670.21 KII60647.1 - 0.02 15.0 0.2 0.036 14.2 0.2 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain EpuA PF11772.8 KII60647.1 - 0.17 11.6 0.3 2.3 8.0 0.1 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase subunit beta GDP_Man_Dehyd PF16363.5 KII60647.1 - 0.2 11.0 0.1 0.28 10.5 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DDE_3 PF13358.6 KII60648.1 - 1.6e-11 44.2 0.1 1.8e-11 44.0 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease RGS PF00615.19 KII60649.1 - 0.069 13.4 1.5 0.092 13.0 0.2 1.8 2 0 0 2 2 2 0 Regulator of G protein signaling domain Ribosomal_L18_c PF14204.6 KII60650.1 - 0.046 14.7 0.0 0.079 13.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal L18 C-terminal region DUF5345 PF17280.2 KII60650.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5345) SCRL PF06876.12 KII60651.1 - 0.035 14.3 0.2 0.05 13.8 0.2 1.2 1 0 0 1 1 1 0 Plant self-incompatibility response (SCRL) protein PurA PF04845.13 KII60656.1 - 1.1e-06 28.2 0.9 0.0001 21.7 0.2 2.2 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein B3 PF02362.21 KII60656.1 - 0.052 13.4 0.2 0.34 10.8 0.1 2.1 1 1 1 2 2 2 0 B3 DNA binding domain HSBP1 PF06825.12 KII60656.1 - 0.12 12.2 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 RepA_C PF04796.12 KII60658.1 - 0.14 12.2 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 Plasmid encoded RepA protein FtsQ PF03799.15 KII60659.1 - 0.033 15.0 0.0 0.074 13.9 0.0 1.6 1 0 0 1 1 1 0 Cell division protein FtsQ Sortilin_C PF15901.5 KII60660.1 - 7.3e-12 46.0 8.0 1.4e-11 45.0 8.0 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII60660.1 - 1.1e-06 27.8 0.0 1.8e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII60660.1 - 0.0079 16.0 0.1 6.4 7.2 0.0 3.1 2 0 0 2 2 2 2 BNR/Asp-box repeat 4HPAD_g_N PF18671.1 KII60662.1 - 0.11 12.2 1.6 0.24 11.1 1.6 1.5 1 0 0 1 1 1 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal DUSP PF06337.12 KII60663.1 - 0.06 14.0 0.4 0.072 13.7 0.4 1.3 1 0 0 1 1 1 0 DUSP domain TMEM70 PF06979.12 KII60664.1 - 2e-08 34.7 0.6 2.6e-08 34.4 0.6 1.2 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex rve PF00665.26 KII60668.1 - 6.2e-13 49.0 0.0 9.6e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII60668.1 - 0.00074 19.2 0.1 0.0017 18.1 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain RNA_pol_Rpb8 PF03870.15 KII60671.1 - 6.7e-45 152.7 0.2 7.5e-45 152.5 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 KII60671.1 - 1e-05 25.6 0.1 0.00016 21.7 0.0 2.0 2 0 0 2 2 2 1 DNA-directed RNA polymerase, subunit G SIS PF01380.22 KII60673.1 - 4.2e-41 139.9 0.1 3.8e-22 78.5 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KII60673.1 - 5.7e-13 49.2 0.0 1.3e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KII60673.1 - 3e-06 26.3 0.0 5.1e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_7 PF13537.6 KII60673.1 - 1.1e-05 25.3 0.0 2.7e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain COP-gamma_platf PF08752.10 KII60673.1 - 0.081 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Coatomer gamma subunit appendage platform subdomain EGF PF00008.27 KII60674.1 - 0.016 15.5 30.3 0.036 14.4 10.0 3.7 3 1 0 3 3 3 0 EGF-like domain EGF_2 PF07974.13 KII60674.1 - 0.024 15.0 10.6 0.024 15.0 10.6 3.3 3 0 0 3 3 3 0 EGF-like domain Laminin_EGF PF00053.24 KII60674.1 - 0.56 10.4 33.6 22 5.3 20.4 3.3 1 1 1 2 2 2 0 Laminin EGF domain EGF_2 PF07974.13 KII60675.1 - 0.39 11.1 39.1 1.2 9.5 9.8 3.7 3 1 0 3 3 3 0 EGF-like domain Conotoxin PF02950.17 KII60677.1 - 0.016 16.2 6.0 0.042 14.9 6.0 1.7 1 1 0 1 1 1 0 Conotoxin Baculo_11_kDa PF06143.11 KII60677.1 - 0.066 12.8 1.7 0.58 9.8 0.6 2.2 2 0 0 2 2 2 0 Baculovirus 11 kDa family Chordopox_A13L PF05961.11 KII60677.1 - 0.56 10.5 2.7 1.7 8.9 1.5 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Nucleoplasmin PF03066.15 KII60679.1 - 2.2e-07 31.3 0.1 4.2e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain Head_binding PF09008.10 KII60679.1 - 7e-06 26.3 0.1 65 3.8 0.0 5.2 5 0 0 5 5 5 0 Head binding Hyr1 PF15789.5 KII60679.1 - 0.0041 16.6 10.9 42 3.8 0.1 6.0 6 0 0 6 6 6 0 Hyphally regulated cell wall GPI-anchored protein 1 FDC-SP PF15215.6 KII60679.1 - 0.32 11.6 6.4 16 6.1 0.1 5.1 6 0 0 6 6 6 0 Follicular dendritic cell secreted peptide Orthopox_35kD PF02250.15 KII60679.1 - 1.2 8.8 18.8 23 4.6 0.4 5.4 1 1 5 6 6 6 0 35kD major secreted virus protein GSHPx PF00255.19 KII60680.1 - 6.5e-18 64.3 1.4 6.9e-18 64.2 0.3 1.7 2 1 0 2 2 2 1 Glutathione peroxidase Epimerase PF01370.21 KII60681.1 - 8.5e-17 61.4 0.0 5.3e-16 58.8 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KII60681.1 - 3e-10 39.6 0.0 3.7e-07 29.4 0.0 2.1 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KII60681.1 - 3.1e-08 33.7 0.0 5.8e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 KII60681.1 - 3e-05 24.3 0.0 0.00012 22.4 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 KII60681.1 - 0.00087 18.8 0.0 0.0018 17.8 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 KII60681.1 - 0.0012 18.0 0.0 0.0026 16.9 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 KII60681.1 - 0.0018 17.7 0.0 0.0094 15.4 0.0 2.1 2 1 1 3 3 3 1 short chain dehydrogenase DUF1731 PF08338.11 KII60681.1 - 0.0045 16.8 0.0 0.0086 15.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) KR PF08659.10 KII60681.1 - 0.0048 16.8 0.0 0.02 14.8 0.0 1.9 1 1 0 1 1 1 1 KR domain UPF1_Zn_bind PF09416.10 KII60681.1 - 0.0083 16.1 0.5 0.016 15.2 0.0 1.7 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) NAD_binding_4 PF07993.12 KII60681.1 - 0.0093 15.2 0.0 0.15 11.2 0.0 2.5 2 1 1 3 3 3 1 Male sterility protein HIM1 PF08732.10 KII60681.1 - 0.046 13.3 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 HIM1 TrkA_N PF02254.18 KII60681.1 - 0.16 12.2 0.0 0.73 10.1 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain Maelstrom PF13017.6 KII60682.1 - 1.3e-22 80.5 0.1 2.1e-22 79.8 0.1 1.3 1 0 0 1 1 1 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.10 KII60682.1 - 0.00037 21.0 0.4 0.0013 19.2 0.4 1.9 1 0 0 1 1 1 1 HMG-box domain DUF4499 PF14934.6 KII60684.1 - 0.048 14.0 9.4 0.09 13.1 9.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4499) DDE_3 PF13358.6 KII60685.1 - 2e-07 30.9 0.2 3.1e-07 30.3 0.2 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease KdgM PF06178.13 KII60686.1 - 8.2e-75 251.2 9.8 9.3e-75 251.1 9.8 1.0 1 0 0 1 1 1 1 Oligogalacturonate-specific porin protein (KdgM) DUF481 PF04338.12 KII60686.1 - 9.6e-06 25.8 8.4 0.0025 17.8 0.5 3.1 2 1 1 3 3 3 2 Protein of unknown function, DUF481 Porin_3 PF01459.22 KII60686.1 - 0.027 13.9 1.1 0.45 9.9 0.1 2.7 1 1 0 2 2 2 0 Eukaryotic porin GerE PF00196.19 KII60687.1 - 4.8e-10 38.8 0.0 9.3e-10 37.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_38 PF13936.6 KII60687.1 - 1.1e-05 25.1 0.8 0.00029 20.5 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.6 KII60687.1 - 9.1e-05 22.5 0.1 0.00044 20.3 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII60687.1 - 0.00054 19.6 0.1 0.0011 18.7 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 KII60687.1 - 0.0016 18.1 0.7 0.0041 16.9 0.1 1.8 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4 PF04545.16 KII60687.1 - 0.0019 17.7 0.6 0.0019 17.7 0.6 1.9 3 0 0 3 3 3 1 Sigma-70, region 4 MCM_lid PF17855.1 KII60687.1 - 0.0052 17.2 0.0 0.09 13.2 0.0 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain HTH_Tnp_ISL3 PF13542.6 KII60687.1 - 0.0057 16.0 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_40 PF14493.6 KII60687.1 - 0.0073 16.7 0.0 0.019 15.4 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain LacI PF00356.21 KII60687.1 - 0.009 15.8 0.1 0.017 14.9 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_29 PF13551.6 KII60687.1 - 0.03 14.3 0.4 0.057 13.4 0.1 1.6 2 0 0 2 2 2 0 Winged helix-turn helix SAP PF02037.27 KII60687.1 - 0.037 13.8 0.2 0.078 12.8 0.2 1.5 1 0 0 1 1 1 0 SAP domain HTH_7 PF02796.15 KII60687.1 - 0.063 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase MarR_2 PF12802.7 KII60687.1 - 0.089 12.7 0.2 0.98 9.4 0.1 2.2 2 0 0 2 2 2 0 MarR family Med26 PF08711.11 KII60688.1 - 0.00012 22.0 0.4 0.00012 22.0 0.4 1.9 2 0 0 2 2 2 1 TFIIS helical bundle-like domain PI3_PI4_kinase PF00454.27 KII60688.1 - 0.032 14.0 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase LEDGF PF11467.8 KII60688.1 - 0.13 11.9 0.5 0.4 10.3 0.5 1.9 1 1 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) HTH_46 PF15977.5 KII60690.1 - 0.04 13.9 2.0 0.21 11.6 0.2 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA binding TCL1_MTCP1 PF01840.17 KII60692.1 - 0.042 13.5 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 TCL1/MTCP1 family Kunitz_BPTI PF00014.23 KII60695.1 - 0.025 14.8 11.9 0.025 14.8 11.9 2.5 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF733 PF05306.11 KII60696.1 - 0.081 13.2 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF733) DUF3641 PF12345.8 KII60696.1 - 0.11 12.5 0.2 0.24 11.4 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3641) rve PF00665.26 KII60697.1 - 3.8e-25 88.4 0.0 6.8e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60697.1 - 0.0011 19.0 1.4 0.0027 17.8 1.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_Tnp_IS240 PF13610.6 KII60697.1 - 0.0027 17.9 0.1 0.0065 16.7 0.0 1.6 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.6 KII60697.1 - 0.0042 16.8 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII60697.1 - 0.076 13.1 0.0 0.26 11.4 0.0 1.9 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain LysM PF01476.20 KII60698.1 - 0.67 10.1 0.1 0.67 10.1 0.1 2.8 3 0 0 3 3 3 0 LysM domain rve PF00665.26 KII60700.1 - 2e-18 66.7 0.0 2.9e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60700.1 - 7.4e-18 64.4 0.1 7.4e-18 64.4 0.1 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII60700.1 - 2.7e-05 23.9 0.0 5.6e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DUF2559 PF10832.8 KII60701.1 - 0.0049 16.9 0.3 0.0076 16.3 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2559) VPS13_C PF16909.5 KII60706.1 - 0.0089 15.8 0.2 0.018 14.9 0.2 1.5 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal EF-hand_1 PF00036.32 KII60707.1 - 2.1e-10 39.4 2.5 3.6e-05 23.0 0.2 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KII60707.1 - 1.6e-07 31.0 1.6 0.002 17.9 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 KII60707.1 - 3.5e-07 30.6 0.5 3.5e-07 30.6 0.5 1.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KII60707.1 - 1.1e-06 28.1 1.8 0.048 13.6 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KII60707.1 - 1.3e-05 24.4 1.3 0.0032 16.9 0.1 2.6 2 0 0 2 2 2 2 EF hand Dockerin_1 PF00404.18 KII60707.1 - 0.0003 20.9 0.2 0.01 16.0 0.3 2.2 1 1 1 2 2 2 2 Dockerin type I domain SCRG1 PF15224.6 KII60707.1 - 0.043 13.9 0.5 0.082 13.0 0.5 1.5 1 0 0 1 1 1 0 Scrapie-responsive protein 1 EF-hand_9 PF14658.6 KII60707.1 - 0.12 12.8 0.2 0.54 10.6 0.1 2.2 2 2 0 2 2 2 0 EF-hand domain DDE_Tnp_IS1595 PF12762.7 KII60708.1 - 6e-08 32.8 0.0 6.3e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Kinesin PF00225.23 KII60709.1 - 7e-45 153.4 0.0 9.7e-45 152.9 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KII60709.1 - 9.1e-14 51.6 1.0 1.1e-11 44.8 0.0 3.0 3 1 1 4 4 4 2 Microtubule binding HCMV_UL139 PF12507.8 KII60710.1 - 0.023 15.1 1.6 0.046 14.1 1.0 1.8 1 1 0 1 1 1 0 Human Cytomegalovirus UL139 protein CC2-LZ PF16516.5 KII60710.1 - 0.058 13.8 0.9 0.058 13.8 0.9 3.0 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Golgin_A5 PF09787.9 KII60710.1 - 0.23 10.9 20.2 0.29 10.6 20.2 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 eIF-4B PF06273.11 KII60710.1 - 0.3 10.1 8.7 0.35 9.9 8.7 1.3 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B Exonuc_VII_L PF02601.15 KII60710.1 - 0.33 10.5 9.6 0.41 10.2 9.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit HMMR_N PF15905.5 KII60710.1 - 0.5 9.8 23.7 0.65 9.4 6.5 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal 60KD_IMP PF02096.20 KII60710.1 - 0.59 10.0 2.6 2.8 7.8 0.7 2.2 2 0 0 2 2 2 0 60Kd inner membrane protein Bacillus_HBL PF05791.11 KII60710.1 - 0.6 9.9 15.2 2.2 8.1 11.1 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ARGLU PF15346.6 KII60710.1 - 0.83 9.5 14.1 1.3 8.9 14.1 1.3 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 FAM76 PF16046.5 KII60710.1 - 1.6 8.0 18.5 1.3 8.3 9.1 2.0 1 1 1 2 2 2 0 FAM76 protein DUF883 PF05957.13 KII60710.1 - 3.1 8.5 6.3 2.8 8.6 3.5 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4407 PF14362.6 KII60710.1 - 4.3 6.6 11.2 12 5.1 11.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2203 PF09969.9 KII60710.1 - 5.8 7.7 8.0 32 5.3 6.4 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DASH_Dam1 PF08653.10 KII60710.1 - 9.3 6.1 6.9 15 5.5 0.2 3.8 1 1 1 2 2 2 0 DASH complex subunit Dam1 DUF16 PF01519.16 KII60710.1 - 9.4 6.8 16.6 21 5.6 3.0 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 HIP1_clath_bdg PF16515.5 KII60710.1 - 9.7 6.9 21.3 1.1 9.9 8.6 3.1 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AIP3 PF03915.13 KII60711.1 - 0.1 11.7 13.6 0.13 11.3 13.6 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 zf-CpG_bind_C PF12269.8 KII60711.1 - 0.7 9.6 11.3 0.38 10.5 4.6 2.3 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain Tmpp129 PF10272.9 KII60711.1 - 1.6 8.0 5.1 1.9 7.7 4.4 1.4 1 1 0 1 1 1 0 Putative transmembrane protein precursor FlaC_arch PF05377.11 KII60711.1 - 2.8 8.4 20.2 5.8 7.4 0.1 4.4 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 KII60711.1 - 7.8 6.5 20.0 3.7 7.6 16.7 1.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Exonuc_VII_L PF02601.15 KII60711.1 - 9.2 5.7 11.5 59 3.1 11.5 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit GTP_EFTU_D2 PF03144.25 KII60712.1 - 0.0023 18.3 0.0 0.0035 17.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu domain 2 IF-2 PF11987.8 KII60713.1 - 5.3e-29 100.4 1.0 9.8e-29 99.6 1.0 1.4 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 KII60713.1 - 0.0094 16.3 2.5 0.59 10.6 0.1 2.6 2 1 0 2 2 2 2 Elongation factor Tu domain 2 IF2_N PF04760.15 KII60714.1 - 1.6e-15 56.7 1.0 3.3e-15 55.6 1.0 1.6 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region GTP_EFTU PF00009.27 KII60714.1 - 9.8e-10 38.3 6.8 5.9e-09 35.8 1.7 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KII60714.1 - 7.4e-07 29.3 0.1 2.7e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 KII60714.1 - 0.0012 18.4 1.2 0.0033 16.9 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit BDV_G PF06208.11 KII60714.1 - 0.044 12.9 0.0 0.06 12.5 0.0 1.1 1 0 0 1 1 1 0 Borna disease virus G protein FeoB_N PF02421.18 KII60714.1 - 0.064 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 KII60714.1 - 4.9 7.2 6.2 11 6.0 0.0 3.1 2 1 1 3 3 3 0 Dynamin family SAPS PF04499.15 KII60714.1 - 5.3 5.7 7.7 7.1 5.3 7.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pterin_bind PF00809.22 KII60715.1 - 3.7e-88 295.3 0.0 4.3e-88 295.1 0.0 1.0 1 0 0 1 1 1 1 Pterin binding enzyme Peptidase_M41 PF01434.18 KII60716.1 - 2.1e-25 89.7 0.1 2.5e-25 89.5 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M41 CSTF2_hinge PF14327.6 KII60716.1 - 0.00018 21.9 0.2 0.00025 21.4 0.2 1.2 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 WD40 PF00400.32 KII60717.1 - 6.1e-13 49.0 0.5 0.15 12.9 0.0 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII60717.1 - 8.3e-06 26.0 0.0 0.61 10.4 0.0 3.4 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 KII60717.1 - 0.00044 19.7 1.2 0.0012 18.4 1.2 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Ge1_WD40 PF16529.5 KII60717.1 - 0.013 14.5 0.0 0.78 8.6 0.0 2.4 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 KII60717.1 - 0.022 13.7 0.0 0.041 12.8 0.0 1.4 1 1 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain DUF3856 PF12968.7 KII60717.1 - 0.055 13.5 0.1 0.09 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) Asp_protease_2 PF13650.6 KII60720.1 - 8.8e-05 23.1 0.0 0.01 16.5 0.0 2.1 1 1 1 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 KII60720.1 - 0.0026 18.3 0.0 0.01 16.4 0.0 1.8 1 1 1 2 2 2 1 gag-polyprotein putative aspartyl protease MRP-S25 PF13741.6 KII60720.1 - 0.054 13.0 0.1 0.091 12.3 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S25 Type2_restr_D3 PF16902.5 KII60720.1 - 0.059 13.3 0.2 0.1 12.5 0.2 1.4 1 0 0 1 1 1 0 Type-2 restriction enzyme D3 domain RVP_2 PF08284.11 KII60720.1 - 0.089 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease GUB_WAK_bind PF13947.6 KII60721.1 - 0.013 16.2 1.3 0.016 15.9 1.3 1.2 1 0 0 1 1 1 0 Wall-associated receptor kinase galacturonan-binding Taxilin PF09728.9 KII60722.1 - 0.00011 21.5 28.4 0.0043 16.3 5.6 3.0 1 1 2 3 3 3 3 Myosin-like coiled-coil protein DED PF01335.21 KII60722.1 - 0.078 13.3 0.2 0.078 13.3 0.2 3.6 3 2 1 4 4 4 0 Death effector domain CENP-H PF05837.12 KII60722.1 - 0.088 13.2 21.4 0.047 14.1 7.9 3.3 2 2 1 3 3 3 0 Centromere protein H (CENP-H) DUF4188 PF13826.6 KII60722.1 - 0.12 12.8 3.2 0.19 12.1 2.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4188) Hemerythrin PF01814.23 KII60722.1 - 0.12 13.0 3.1 11 6.7 0.2 3.0 3 1 0 3 3 3 0 Hemerythrin HHE cation binding domain DHR10 PF18595.1 KII60722.1 - 0.16 12.0 27.0 0.65 10.1 6.9 3.8 2 2 1 3 3 3 0 Designed helical repeat protein 10 domain Laminin_II PF06009.12 KII60722.1 - 0.32 11.0 24.5 0.26 11.3 3.1 3.9 1 1 3 4 4 4 0 Laminin Domain II Vfa1 PF08432.10 KII60722.1 - 0.39 11.0 17.3 0.044 14.1 5.6 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 OmpH PF03938.14 KII60722.1 - 0.47 10.8 26.2 0.56 10.5 9.6 2.8 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 KII60722.1 - 1.2 8.3 20.3 1.1 8.5 7.6 2.2 2 0 0 2 2 2 0 TMPIT-like protein APG17 PF04108.12 KII60722.1 - 1.4 7.9 26.2 0.43 9.6 9.4 2.3 1 1 1 2 2 2 0 Autophagy protein Apg17 Flu_NS2 PF00601.19 KII60722.1 - 1.6 9.1 12.1 0.13 12.6 3.8 2.8 2 1 0 2 2 2 0 Influenza non-structural protein (NS2) DUF5082 PF16888.5 KII60722.1 - 2 8.7 26.7 3.7 7.8 13.9 2.7 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) DUF1664 PF07889.12 KII60722.1 - 3.2 7.8 22.3 0.65 10.1 5.1 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) ArgoMid PF16487.5 KII60722.1 - 4.1 7.7 6.9 3.1 8.1 0.7 3.2 3 0 0 3 3 3 0 Mid domain of argonaute DUF4407 PF14362.6 KII60722.1 - 4.8 6.4 15.3 3.6 6.9 6.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) FapA PF03961.13 KII60722.1 - 5.5 5.5 26.2 1.4 7.4 7.6 2.2 1 1 0 2 2 2 0 Flagellar Assembly Protein A DUF1090 PF06476.12 KII60722.1 - 5.7 7.1 11.3 3 8.0 0.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1090) HOOK PF05622.12 KII60722.1 - 6.3 4.8 31.5 3.9 5.5 10.0 2.3 1 1 0 2 2 2 0 HOOK protein SOAR PF16533.5 KII60722.1 - 9.4 6.3 12.9 0.66 10.0 1.3 3.4 2 2 1 3 3 3 0 STIM1 Orai1-activating region SAC3_GANP PF03399.16 KII60723.1 - 1.3e-20 74.0 6.1 4.1e-19 69.1 6.1 2.2 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 KII60723.1 - 4.8e-06 26.6 0.4 9.6e-06 25.6 0.4 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family UPF0175 PF03683.13 KII60723.1 - 0.023 14.4 0.0 0.13 12.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0175) DUF3543 PF12063.8 KII60723.1 - 5.7 6.2 8.9 1.5 8.1 1.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3543) ATP_bind_1 PF03029.17 KII60724.1 - 1.1e-61 208.7 0.1 1.3e-61 208.4 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 KII60724.1 - 0.002 18.4 0.0 0.0044 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KII60724.1 - 0.014 15.5 0.0 0.046 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KII60724.1 - 0.024 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.14 KII60724.1 - 0.032 14.2 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KII60724.1 - 0.069 12.7 0.0 0.25 10.8 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 KII60724.1 - 0.08 13.1 0.0 0.12 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 KII60724.1 - 0.081 12.5 0.1 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 KII60724.1 - 0.086 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 KII60724.1 - 0.095 13.1 0.0 0.27 11.7 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ADK PF00406.22 KII60724.1 - 0.095 12.8 0.0 4.4 7.4 0.0 2.4 2 1 0 2 2 2 0 Adenylate kinase AAA_18 PF13238.6 KII60724.1 - 0.1 13.2 0.1 0.41 11.2 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KII60724.1 - 0.12 12.8 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Imm6 PF14434.6 KII60725.1 - 0.075 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Immunity protein Imm6 HTH_Tnp_IS630 PF01710.16 KII60726.1 - 0.0005 20.1 0.0 0.00091 19.3 0.0 1.3 1 0 0 1 1 1 1 Transposase YuiB PF14068.6 KII60726.1 - 0.22 12.2 1.9 2 9.0 0.0 2.5 2 1 1 3 3 3 0 Putative membrane protein Mfa_like_2 PF15415.6 KII60727.1 - 0.086 11.7 0.1 0.14 11.0 0.1 1.4 1 1 0 1 1 1 0 Fimbrillin-like RVP PF00077.20 KII60730.1 - 0.011 16.0 0.0 0.031 14.6 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII60730.1 - 0.012 16.1 0.0 0.086 13.4 0.0 2.4 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease TTRAP PF14203.6 KII60731.1 - 0.016 15.2 2.7 0.19 11.7 0.1 2.5 2 1 1 3 3 3 0 Putative tranposon-transfer assisting protein DUF948 PF06103.11 KII60731.1 - 0.038 14.2 0.8 0.16 12.2 0.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FliD_N PF02465.18 KII60731.1 - 0.061 14.0 1.0 0.087 13.5 0.2 1.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus NPV_P10 PF05531.12 KII60731.1 - 0.072 13.6 1.2 0.072 13.6 1.2 2.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TPR_MLP1_2 PF07926.12 KII60731.1 - 0.081 13.0 0.5 0.081 13.0 0.5 1.9 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Corona_S2 PF01601.16 KII60731.1 - 0.098 11.1 1.2 0.14 10.6 1.2 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Polysacc_deac_2 PF04748.13 KII60731.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase TIC20 PF16166.5 KII60731.1 - 0.13 12.0 0.1 0.19 11.5 0.1 1.2 1 0 0 1 1 1 0 Chloroplast import apparatus Tic20-like DASH_Dad1 PF08649.10 KII60731.1 - 0.2 11.8 4.9 0.12 12.6 1.4 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad1 BLOC1_2 PF10046.9 KII60731.1 - 3.3 8.1 7.5 0.59 10.5 2.6 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Phage_Gp23 PF10669.9 KII60731.1 - 9.9 6.5 12.9 0.8 10.0 2.6 2.7 2 1 1 3 3 3 0 Protein gp23 (Bacteriophage A118) ECR1_N PF14382.6 KII60732.1 - 8.3e-09 35.1 0.1 2.3e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region Ribosomal_L27 PF01016.19 KII60732.1 - 0.00064 19.7 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein XRN1_D2_D3 PF18334.1 KII60732.1 - 0.046 13.9 0.0 0.28 11.4 0.0 2.0 2 0 0 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain ECR1_N PF14382.6 KII60734.1 - 8.3e-09 35.1 0.1 2.3e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region Ribosomal_L27 PF01016.19 KII60734.1 - 0.00064 19.7 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein XRN1_D2_D3 PF18334.1 KII60734.1 - 0.046 13.9 0.0 0.28 11.4 0.0 2.0 2 0 0 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain Acetyltransf_1 PF00583.25 KII60737.1 - 3.2e-11 43.5 0.0 4.7e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII60737.1 - 6.5e-11 42.3 0.0 8.9e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII60737.1 - 2.7e-08 34.1 0.0 4.4e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KII60737.1 - 2.2e-06 27.5 0.0 3.5e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 KII60737.1 - 0.011 15.9 0.4 0.015 15.5 0.4 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain MULE PF10551.9 KII60738.1 - 1.6e-13 50.9 2.8 3e-13 50.0 1.7 2.1 2 0 0 2 2 2 1 MULE transposase domain FLYWCH PF04500.16 KII60738.1 - 2.1e-05 24.5 1.8 5.4e-05 23.2 1.4 2.0 2 0 0 2 2 2 1 FLYWCH zinc finger domain DDE_Tnp_IS1595 PF12762.7 KII60739.1 - 4e-17 62.6 0.0 6.7e-17 61.9 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain Cyt-b5 PF00173.28 KII60740.1 - 9.1e-19 67.4 0.0 1.1e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Aldedh PF00171.22 KII60741.1 - 2.1e-84 283.7 0.0 3.7e-84 282.9 0.0 1.3 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Cyt_bd_oxida_I PF01654.17 KII60743.1 - 0.0026 16.4 0.1 0.0029 16.3 0.1 1.1 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit I TMEM144 PF07857.12 KII60743.1 - 0.015 14.2 0.0 0.027 13.4 0.0 1.3 1 1 0 1 1 1 0 Transmembrane family, TMEM144 of transporters Ldl_recept_a PF00057.18 KII60744.1 - 2.1e-06 27.8 12.8 2.1e-06 27.8 12.8 2.2 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A SNAP PF14938.6 KII60746.1 - 5.7e-05 22.7 0.7 0.00027 20.5 0.1 1.9 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP RuBisCO_small PF00101.20 KII60746.1 - 0.079 13.0 0.2 0.19 11.7 0.0 1.9 2 1 0 2 2 2 0 Ribulose bisphosphate carboxylase, small chain DUF4373 PF14297.6 KII60746.1 - 0.5 11.2 3.1 0.35 11.7 1.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) DUF3181 PF11378.8 KII60747.1 - 0.013 15.8 0.0 0.027 14.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3181) DDE_3 PF13358.6 KII60748.1 - 6.8e-09 35.6 0.1 8.8e-09 35.3 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease 3H PF02829.14 KII60748.1 - 0.035 14.4 0.1 0.059 13.7 0.1 1.4 1 0 0 1 1 1 0 3H domain PAX PF00292.18 KII60749.1 - 5.2e-09 36.1 0.3 7.4e-09 35.6 0.1 1.5 2 0 0 2 2 2 1 'Paired box' domain HTH_32 PF13565.6 KII60749.1 - 0.027 15.1 0.4 0.12 13.0 0.2 2.0 1 1 1 2 2 2 0 Homeodomain-like domain DNA_meth_N PF18284.1 KII60749.1 - 0.083 12.8 0.1 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 DNA methylase N-terminal domain zf-C3HC4_3 PF13920.6 KII60751.1 - 4.8e-08 32.7 5.3 6.6e-08 32.3 5.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII60751.1 - 7.2e-05 23.0 7.5 0.00011 22.4 7.5 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KII60751.1 - 0.0026 17.6 6.2 0.0042 16.9 6.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KII60751.1 - 0.0055 16.5 8.5 0.0096 15.8 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KII60751.1 - 0.013 15.3 9.5 0.054 13.3 9.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 KII60751.1 - 0.016 14.8 2.4 0.024 14.3 2.4 1.2 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_5 PF14634.6 KII60751.1 - 0.31 11.0 9.4 2 8.5 9.4 2.0 1 1 0 1 1 1 0 zinc-RING finger domain ADD_DNMT3 PF17980.1 KII60751.1 - 0.67 10.0 5.4 0.57 10.2 4.0 1.6 1 1 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 zinc_ribbon_9 PF14369.6 KII60751.1 - 2.8 8.3 7.6 1.8 8.9 3.9 2.5 2 1 0 2 2 2 0 zinc-ribbon DDE_Tnp_IS1595 PF12762.7 KII60752.1 - 0.0041 17.2 0.0 0.0044 17.0 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII60754.1 - 2.7e-15 56.7 0.2 3.1e-15 56.5 0.2 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain PrmC_N PF17827.1 KII60754.1 - 0.078 13.6 0.0 1.8 9.2 0.0 2.1 2 0 0 2 2 2 0 PrmC N-terminal domain Thr_dehydrat_C PF00585.18 KII60755.1 - 0.039 13.7 0.1 0.073 12.8 0.0 1.5 1 1 1 2 2 2 0 C-terminal regulatory domain of Threonine dehydratase Thioredoxin PF00085.20 KII60757.1 - 1.4e-06 28.3 0.5 2.1e-06 27.7 0.5 1.3 1 0 0 1 1 1 1 Thioredoxin EphA2_TM PF14575.6 KII60758.1 - 0.015 16.2 0.0 0.032 15.1 0.0 1.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain BatD PF13584.6 KII60758.1 - 0.018 13.8 0.1 0.022 13.6 0.1 1.0 1 0 0 1 1 1 0 Oxygen tolerance SpvD PF05563.12 KII60758.1 - 0.029 14.0 0.1 0.038 13.6 0.1 1.1 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD LMBR1 PF04791.16 KII60758.1 - 0.031 13.2 0.0 0.036 13.0 0.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4446 PF14584.6 KII60758.1 - 0.07 13.1 0.8 9.4 6.2 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) adh_short PF00106.25 KII60759.1 - 5e-10 39.2 0.0 2.9e-09 36.7 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KII60759.1 - 0.00013 21.9 0.0 0.00023 21.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KII60759.1 - 0.00017 21.1 0.0 0.00029 20.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 KII60759.1 - 0.0014 18.2 0.0 0.007 15.9 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DapB_N PF01113.20 KII60759.1 - 0.0028 17.8 0.1 0.0076 16.4 0.1 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 KII60759.1 - 0.0063 16.8 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 KII60759.1 - 0.019 15.4 0.0 0.032 14.6 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CPSase_sm_chain PF00988.22 KII60759.1 - 0.068 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain NAD_binding_10 PF13460.6 KII60759.1 - 0.078 12.9 0.0 0.44 10.4 0.0 2.0 2 0 0 2 2 2 0 NAD(P)H-binding Sec1 PF00995.23 KII60760.1 - 1e-08 34.9 0.1 1.7e-08 34.2 0.1 1.3 1 1 0 1 1 1 1 Sec1 family DDE_3 PF13358.6 KII60762.1 - 1.5e-10 41.0 0.2 1.9e-10 40.6 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII60762.1 - 0.049 13.8 0.0 0.069 13.4 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Pro-NT_NN PF07421.11 KII60762.1 - 0.063 13.5 0.1 0.087 13.1 0.1 1.1 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor Ribosomal_L37 PF08561.10 KII60762.1 - 0.066 13.7 0.1 0.076 13.5 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 DUF4577 PF15145.6 KII60765.1 - 0.039 14.0 0.2 0.089 12.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) Sortilin_C PF15901.5 KII60766.1 - 1.5e-11 44.9 1.6 2.3e-11 44.3 1.6 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII60766.1 - 5.2e-11 42.0 1.2 1.1e-10 41.0 1.2 1.4 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII60766.1 - 3e-06 26.4 3.7 0.062 13.3 0.2 3.7 3 0 0 3 3 3 3 BNR/Asp-box repeat Sortilin_C PF15901.5 KII60767.1 - 4.5e-11 43.4 0.5 5e-11 43.2 0.5 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal NosD PF05048.13 KII60767.1 - 0.013 14.8 2.7 0.017 14.4 2.7 1.1 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) rve PF00665.26 KII60769.1 - 1.2e-19 70.6 0.1 1.8e-19 70.0 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60769.1 - 1.1e-16 60.6 0.3 2.6e-16 59.5 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII60769.1 - 9.3e-05 22.6 0.6 0.00022 21.4 0.1 1.9 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII60769.1 - 0.0005 19.8 0.0 0.0013 18.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII60769.1 - 0.052 13.3 0.0 0.093 12.5 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Nepo_coat_N PF03689.15 KII60769.1 - 0.061 13.3 0.1 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain DDE_Tnp_IS1595 PF12762.7 KII60770.1 - 3.8e-12 46.5 0.0 4.5e-12 46.2 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF5483 PF17581.2 KII60772.1 - 0.049 12.5 0.0 0.057 12.3 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5483) E3_UFM1_ligase PF09743.9 KII60774.1 - 9e-17 61.6 3.4 9.7e-17 61.5 3.4 1.0 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 PhoLip_ATPase_C PF16212.5 KII60775.1 - 5.1e-52 177.1 28.7 9.4e-52 176.2 28.7 1.4 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 KII60775.1 - 5e-13 48.9 0.0 4.8e-12 45.8 0.0 2.5 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KII60775.1 - 1e-09 39.0 0.0 3.8e-06 27.4 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KII60775.1 - 0.03 14.1 0.2 0.03 14.1 0.2 2.2 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase rve PF00665.26 KII60776.1 - 3.9e-22 78.7 0.0 6e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII60776.1 - 0.003 17.6 0.0 0.0074 16.4 0.0 1.7 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII60776.1 - 0.0087 15.8 1.0 0.27 11.1 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain MEA1 PF06910.11 KII60776.1 - 0.048 14.3 0.1 0.13 12.9 0.0 1.7 2 0 0 2 2 2 0 Male enhanced antigen 1 (MEA1) DUF3320 PF11784.8 KII60776.1 - 0.061 13.3 0.1 0.4 10.7 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3320) AAT PF03417.16 KII60781.1 - 0.089 12.5 0.4 0.14 11.8 0.4 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase RT_RNaseH PF17917.1 KII60783.1 - 5.1e-24 84.6 0.0 7.3e-24 84.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII60783.1 - 1.4e-14 53.9 0.1 2.6e-14 53.1 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60784.1 - 6.3e-36 122.8 0.0 1.1e-35 122.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII60784.1 - 2.3e-34 117.4 0.0 4.2e-34 116.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII60784.1 - 4.1e-05 23.6 0.0 0.00013 21.9 0.0 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 KII60785.1 - 9.7e-10 38.4 0.0 1.6e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60785.1 - 4.9e-09 36.4 0.0 8e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Cellsynth_D PF03500.13 KII60788.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Cellulose synthase subunit D FAM60A PF15396.6 KII60789.1 - 7.2e-07 29.4 0.1 1.1e-06 28.8 0.1 1.3 1 0 0 1 1 1 1 Protein Family FAM60A Gal-3-0_sulfotr PF06990.11 KII60790.1 - 8.2e-32 110.6 4.9 4.9e-31 108.0 4.9 1.8 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase zf-C2H2_10 PF16588.5 KII60791.1 - 0.017 14.9 2.0 0.03 14.1 2.0 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger PAN_3 PF08277.12 KII60796.1 - 2.3 8.1 26.3 0.038 13.8 7.0 3.5 4 0 0 4 4 4 0 PAN-like domain rve PF00665.26 KII60797.1 - 1.3e-24 86.7 0.0 2.3e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII60797.1 - 0.0027 17.9 0.5 0.011 16.0 0.0 2.0 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.6 KII60797.1 - 0.004 16.9 0.0 0.013 15.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 KII60797.1 - 0.074 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DDE_3 PF13358.6 KII60798.1 - 4e-07 29.9 0.1 1.5e-06 28.0 0.0 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease TFIIA_gamma_N PF02268.16 KII60803.1 - 1.2e-13 50.9 0.1 1.8e-13 50.3 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 KII60803.1 - 6.1e-08 32.7 0.3 9.7e-08 32.0 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit Methyltransf_10 PF05971.12 KII60804.1 - 9.6e-48 163.0 0.0 6.4e-34 117.6 0.0 2.1 1 1 1 2 2 2 2 RNA methyltransferase MTS PF05175.14 KII60804.1 - 0.0049 16.4 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain DNApol_Exo PF18136.1 KII60806.1 - 1.3e-69 234.4 0.0 1.3e-68 231.2 0.0 2.1 1 1 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 KII60806.1 - 3.2e-36 125.2 0.0 5.2e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 KII60806.1 - 4.1e-05 23.4 0.0 0.0001 22.1 0.0 1.7 1 0 0 1 1 1 1 3'-5' exonuclease AC_N PF16214.5 KII60810.1 - 9 5.3 7.0 11 5.1 7.0 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region UDPG_MGDP_dh_N PF03721.14 KII60811.1 - 2e-22 79.7 0.0 2.2e-22 79.5 0.0 1.0 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 KII60811.1 - 0.057 12.6 0.1 0.089 12.0 0.1 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_C PF03720.15 KII60812.1 - 8.3e-30 103.3 0.1 1.1e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_synthase PF02540.17 KII60812.1 - 0.038 13.1 0.1 0.046 12.8 0.1 1.1 1 0 0 1 1 1 0 NAD synthase Rgp1 PF08737.10 KII60813.1 - 0.0064 15.7 0.2 0.026 13.7 0.0 1.7 1 1 1 2 2 2 1 Rgp1 Mob1_phocein PF03637.17 KII60814.1 - 9.5e-65 217.7 0.1 1.1e-64 217.5 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family Phosducin PF02114.16 KII60814.1 - 0.052 12.5 0.0 0.14 11.1 0.0 1.6 1 1 1 2 2 2 0 Phosducin DDE_1 PF03184.19 KII60816.1 - 4.2e-12 46.1 0.0 6.9e-12 45.4 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease PAC3 PF10178.9 KII60817.1 - 0.082 13.1 0.0 1.5 9.0 0.0 2.2 1 1 0 1 1 1 0 Proteasome assembly chaperone 3 ABC_tran PF00005.27 KII60821.1 - 0.0029 18.1 0.0 0.0042 17.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KII60821.1 - 0.053 12.9 0.0 0.074 12.5 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ACTH_domain PF00976.18 KII60822.1 - 1.6 8.8 5.6 2.8 8.0 5.6 1.4 1 0 0 1 1 1 0 Corticotropin ACTH domain Radical_SAM PF04055.21 KII60824.1 - 9.9e-17 61.8 0.1 1.5e-16 61.2 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.20 KII60824.1 - 1.5e-08 34.5 0.3 6.8e-08 32.4 0.1 2.1 2 0 0 2 2 2 1 TRAM domain TRAM_2 PF18693.1 KII60824.1 - 0.042 14.0 0.1 0.21 11.8 0.1 2.2 1 1 0 1 1 1 0 TRAM domain CMD PF02627.20 KII60824.1 - 0.22 11.6 0.1 0.65 10.1 0.1 1.8 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family Malt_amylase_C PF16657.5 KII60826.1 - 0.05 13.7 0.0 0.071 13.2 0.0 1.2 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain Ten1 PF12658.7 KII60826.1 - 0.078 12.9 0.0 0.086 12.8 0.0 1.1 1 0 0 1 1 1 0 Telomere capping, CST complex subunit TIP41 PF04176.13 KII60826.1 - 0.14 11.6 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 TIP41-like family DDE_3 PF13358.6 KII60828.1 - 8.1e-25 87.3 0.0 1.3e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease CbiG_N PF11760.8 KII60828.1 - 0.029 14.4 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 Cobalamin synthesis G N-terminal RT_RNaseH_2 PF17919.1 KII60829.1 - 7.8e-09 35.5 0.0 1.1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII60829.1 - 3.3e-07 30.5 0.0 5.5e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII60829.1 - 0.0012 18.4 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4174 PF13778.6 KII60829.1 - 0.045 14.2 0.0 0.062 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) HTH_6 PF01418.17 KII60829.1 - 0.091 12.8 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family rve PF00665.26 KII60830.1 - 4.7e-08 33.2 0.0 6.2e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain SNAP PF14938.6 KII60833.1 - 8.7e-15 54.9 3.0 1.6e-14 54.0 3.0 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Cas_Csn2 PF09711.10 KII60833.1 - 0.00064 19.4 0.4 0.0019 17.9 0.1 2.1 2 1 0 2 2 2 1 CRISPR-associated protein (Cas_Csn2) TPR_2 PF07719.17 KII60833.1 - 0.0042 17.1 6.6 0.37 11.0 0.6 4.6 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII60833.1 - 0.0072 16.6 3.0 0.78 10.1 1.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KII60833.1 - 0.12 13.2 0.7 18 6.5 0.1 3.9 5 1 0 5 5 5 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.16 KII60833.1 - 0.14 12.2 1.9 1.6 8.9 0.1 3.0 3 0 0 3 3 3 0 Exonuclease VII small subunit TPR_8 PF13181.6 KII60833.1 - 0.48 10.8 7.9 0.79 10.1 0.7 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat NSF PF02071.20 KII60833.1 - 0.93 10.5 7.7 1.4e+02 4.0 0.1 5.5 5 1 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat DUF5104 PF17117.5 KII60834.1 - 0.00055 20.3 1.0 0.0012 19.3 1.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5104) TetR PF13972.6 KII60836.1 - 0.2 11.4 2.1 0.27 10.9 1.8 1.4 1 1 0 1 1 1 0 Bacterial transcriptional repressor Glyco_hydro_38N PF01074.22 KII60837.1 - 3.8e-31 108.5 0.0 6.2e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 KII60837.1 - 1.4e-20 74.3 0.0 2.6e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 KII60837.1 - 0.00036 20.6 0.0 0.00081 19.5 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Amidase PF01425.21 KII60839.1 - 1.8e-09 37.1 0.0 2.5e-09 36.6 0.0 1.2 1 1 0 1 1 1 1 Amidase zf-CCHC PF00098.23 KII60841.1 - 1.9e-06 27.7 7.8 0.00087 19.3 0.4 2.4 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII60841.1 - 3.5e-06 27.2 0.0 7.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII60841.1 - 0.0025 18.4 0.0 0.0052 17.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII60841.1 - 0.0061 17.2 0.0 0.018 15.7 0.0 1.8 2 0 0 2 2 2 1 Aspartyl protease Copper-fist PF00649.18 KII60841.1 - 0.0067 15.9 0.8 0.0067 15.9 0.8 1.9 2 0 0 2 2 2 1 Copper fist DNA binding domain RVT_1 PF00078.27 KII60841.1 - 0.011 15.3 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_A2E PF12382.8 KII60841.1 - 0.015 15.3 0.2 0.037 14.0 0.2 1.7 1 1 0 1 1 1 0 Retrotransposon peptidase zf-CCHC_4 PF14392.6 KII60841.1 - 0.016 14.9 6.9 1.3 8.8 0.7 2.6 2 0 0 2 2 2 0 Zinc knuckle Asp_protease PF09668.10 KII60841.1 - 0.17 11.7 0.6 0.31 10.8 0.6 1.4 1 0 0 1 1 1 0 Aspartyl protease C1_1 PF00130.22 KII60842.1 - 0.0042 16.9 1.3 0.0078 16.1 1.3 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Tospo_nucleocap PF01533.16 KII60842.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Tospovirus nucleocapsid protein Stc1 PF12898.7 KII60842.1 - 0.48 11.0 3.1 0.27 11.8 1.4 1.5 2 0 0 2 2 2 0 Stc1 domain FYVE PF01363.21 KII60842.1 - 0.58 10.3 6.2 0.87 9.8 6.2 1.5 1 1 0 1 1 1 0 FYVE zinc finger zf-UBR PF02207.20 KII60843.1 - 1.2e-12 47.8 7.8 1.2e-12 47.8 7.8 3.4 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) VPS13_C PF16909.5 KII60845.1 - 1.1e-23 84.0 11.7 1.1e-20 74.1 1.0 2.9 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal DUF4537 PF15057.6 KII60846.1 - 7.5e-11 42.1 0.7 8e-06 25.9 0.3 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4537) Tudor_2 PF18104.1 KII60846.1 - 0.0019 17.8 6.0 0.01 15.5 0.4 3.7 3 1 0 3 3 3 1 Jumonji domain-containing protein 2A Tudor domain DDE_Tnp_IS1595 PF12762.7 KII60848.1 - 1.9e-12 47.5 0.8 3.8e-12 46.5 0.4 1.7 1 1 1 2 2 2 1 ISXO2-like transposase domain Acetyltransf_19 PF18015.1 KII60848.1 - 0.051 13.8 0.1 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Cpn60_TCP1 PF00118.24 KII60849.1 - 2.2e-145 485.1 14.2 2.5e-145 484.9 14.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family rve PF00665.26 KII60850.1 - 1.4e-20 73.7 0.0 4.2e-20 72.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII60850.1 - 2.7e-18 65.8 0.1 6e-18 64.7 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 KII60850.1 - 1.1e-13 51.4 0.0 2.3e-12 47.1 0.0 2.7 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 KII60850.1 - 1.1e-06 28.3 0.0 2.3e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII60850.1 - 0.0051 17.0 0.2 0.017 15.3 0.0 2.0 2 0 0 2 2 2 1 H2C2 zinc finger RT_RNaseH_2 PF17919.1 KII60850.1 - 0.0062 16.5 0.2 0.049 13.7 0.0 2.4 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase zf-RING_2 PF13639.6 KII60853.1 - 2.1e-09 37.6 6.9 3.7e-09 36.8 6.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KII60853.1 - 3.9e-08 32.9 2.8 3.9e-08 32.9 2.8 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 KII60853.1 - 9.7e-07 28.7 6.4 1.6e-06 28.0 6.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 KII60853.1 - 2.7e-05 24.4 7.6 7.1e-05 23.0 7.6 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KII60853.1 - 3.4e-05 23.6 4.9 6e-05 22.8 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KII60853.1 - 3.5e-05 23.7 5.6 8.4e-05 22.5 1.5 2.3 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KII60853.1 - 5.2e-05 23.0 4.6 8.8e-05 22.3 4.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KII60853.1 - 6.1e-05 22.8 6.7 0.00011 21.9 6.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KII60853.1 - 0.00015 21.5 6.9 0.00031 20.6 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KII60853.1 - 0.00074 19.5 5.4 0.0086 16.1 5.4 2.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_5 PF17121.5 KII60853.1 - 0.0079 16.1 6.3 0.91 9.5 0.1 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Zf_RING PF16744.5 KII60853.1 - 0.029 14.5 3.3 0.029 14.5 3.3 1.7 1 1 0 1 1 1 0 KIAA1045 RING finger zf-C3H2C3 PF17122.5 KII60853.1 - 0.097 12.7 4.6 0.24 11.5 4.6 1.7 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 KII60853.1 - 0.74 9.8 6.0 3.2 7.7 6.2 1.9 1 1 1 2 2 2 0 PHD-finger Prok-RING_1 PF14446.6 KII60853.1 - 1.5 8.8 5.9 8 6.5 4.2 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4_4 PF15227.6 KII60853.1 - 2.6 8.3 7.7 24 5.2 8.0 2.4 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DDE_3 PF13358.6 KII60854.1 - 3.2e-14 52.9 0.1 3.8e-14 52.7 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease RIBIOP_C PF04950.12 KII60856.1 - 0.0066 15.9 0.1 0.012 15.1 0.1 1.4 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Glyco_transf_10 PF00852.19 KII60857.1 - 3e-38 131.3 0.5 5.2e-38 130.5 0.5 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 KII60857.1 - 0.00042 20.7 0.5 0.0015 18.9 0.1 2.1 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 KII60858.1 - 7.3e-42 143.1 0.4 1.1e-41 142.5 0.4 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DUF4450 PF14614.6 KII60858.1 - 0.00094 18.8 0.1 0.0023 17.6 0.0 1.6 1 1 0 2 2 2 1 Domain of unknown function (DUF4450) Glyco_transf_10 PF00852.19 KII60859.1 - 2.1e-41 141.6 1.6 3.6e-41 140.8 1.6 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DDE_3 PF13358.6 KII60860.1 - 0.011 15.5 0.0 0.03 14.1 0.0 1.7 1 1 1 2 2 2 0 DDE superfamily endonuclease CNOT11 PF10155.9 KII60860.1 - 0.03 14.5 0.1 0.042 14.0 0.1 1.4 1 1 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 Desulfoferrod_N PF06397.12 KII60863.1 - 0.092 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain pEK499_p136 PF18736.1 KII60864.1 - 0.049 13.3 0.1 0.065 12.8 0.1 1.2 1 0 0 1 1 1 0 HEPN pEK499 p136 RAMP4 PF06624.12 KII60866.1 - 0.0082 16.2 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Herpes_UL69 PF05459.12 KII60866.1 - 0.01 15.2 1.2 0.013 14.8 1.2 1.1 1 0 0 1 1 1 0 Herpesvirus transcriptional regulator family Sigma_reg_N PF13800.6 KII60866.1 - 0.018 15.3 1.3 0.018 15.3 1.3 2.2 2 1 0 2 2 2 0 Sigma factor regulator N-terminal DUF4500 PF14937.6 KII60867.1 - 0.025 14.6 0.7 0.07 13.2 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4500) AMA-1 PF02430.15 KII60868.1 - 0.0089 15.0 1.0 0.01 14.9 1.0 1.0 1 0 0 1 1 1 1 Apical membrane antigen 1 DUF3844 PF12955.7 KII60868.1 - 0.013 15.6 0.8 0.026 14.7 0.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3844) SNAP PF14938.6 KII60872.1 - 2.2e-15 56.8 0.6 3.5e-15 56.2 0.6 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII60872.1 - 0.0065 16.7 0.9 0.38 11.1 0.0 3.0 3 1 1 4 4 4 1 Tetratricopeptide repeat PPR PF01535.20 KII60872.1 - 0.15 12.4 3.0 23 5.5 0.1 3.5 3 0 0 3 3 3 0 PPR repeat SHS2_Rpb7-N PF03876.17 KII60873.1 - 0.019 15.3 0.0 0.046 14.1 0.0 1.7 2 0 0 2 2 2 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RPA43_OB PF17875.1 KII60873.1 - 0.081 13.6 0.0 0.14 12.8 0.0 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I DIX PF00778.17 KII60874.1 - 0.84 9.5 5.1 0.43 10.4 1.0 2.5 2 0 0 2 2 2 0 DIX domain gag-asp_proteas PF13975.6 KII60875.1 - 0.00065 20.2 0.0 0.0025 18.4 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease CDC37_M PF08565.11 KII60875.1 - 0.057 13.4 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Cdc37 Hsp90 binding domain TAP35_44 PF07265.11 KII60875.1 - 0.06 13.4 0.3 0.1 12.6 0.3 1.3 1 0 0 1 1 1 0 Tapetum specific protein TAP35/TAP44 Asp_protease PF09668.10 KII60875.1 - 0.061 13.1 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Aspartyl protease Asp_protease_2 PF13650.6 KII60875.1 - 0.14 12.8 0.1 1.1 9.9 0.0 2.2 2 0 0 2 2 2 0 Aspartyl protease SBD_N PF07005.11 KII60876.1 - 0.017 14.9 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Sugar-binding N-terminal domain zf-CCHC PF00098.23 KII60876.1 - 0.019 15.0 2.0 0.051 13.7 2.0 1.7 1 0 0 1 1 1 0 Zinc knuckle rve PF00665.26 KII60877.1 - 2.2e-14 53.7 0.0 3.1e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII60877.1 - 0.0079 16.0 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Vasohibin PF14822.6 KII60878.1 - 0.031 13.5 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 Vasohibin HTH_Crp_2 PF13545.6 KII60883.1 - 0.06 13.3 0.0 0.087 12.8 0.0 1.4 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain adh_short_C2 PF13561.6 KII60885.1 - 2.3e-54 184.5 0.0 2.7e-54 184.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KII60885.1 - 1.9e-51 174.3 0.1 2.5e-51 173.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KII60885.1 - 1.3e-11 44.8 0.0 2e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 KR domain PALP PF00291.25 KII60885.1 - 0.041 13.3 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme MFS_1 PF07690.16 KII60886.1 - 1.1e-25 90.4 37.0 1.1e-25 90.4 37.0 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Nuc_H_symport PF03825.16 KII60886.1 - 2e-06 27.1 23.1 3.3e-06 26.4 23.1 1.2 1 0 0 1 1 1 1 Nucleoside H+ symporter MFS_1_like PF12832.7 KII60886.1 - 2e-05 23.7 8.5 2e-05 23.7 8.5 3.4 2 1 1 3 3 3 1 MFS_1 like family LacY_symp PF01306.19 KII60886.1 - 0.00093 18.1 14.8 0.00093 18.1 14.8 1.8 2 1 0 2 2 2 1 LacY proton/sugar symporter Abhydrolase_9_N PF15420.6 KII60886.1 - 0.0031 17.5 11.5 0.25 11.3 0.2 4.0 3 2 2 5 5 5 2 Alpha/beta-hydrolase family N-terminus ATP_synt_H PF05493.13 KII60886.1 - 0.14 12.6 0.2 0.14 12.6 0.2 5.1 5 3 0 5 5 5 0 ATP synthase subunit H SNAP PF14938.6 KII60887.1 - 3.7e-07 29.8 0.2 4.5e-07 29.6 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP FAD_binding_7 PF03441.14 KII60887.1 - 0.022 14.3 0.1 0.045 13.2 0.1 1.4 1 1 0 1 1 1 0 FAD binding domain of DNA photolyase Endotoxin_C PF03944.14 KII60888.1 - 0.0016 18.8 0.6 0.0022 18.3 0.6 1.3 1 0 0 1 1 1 1 delta endotoxin RhoGEF PF00621.20 KII60890.1 - 3.5e-32 112.1 1.7 3.5e-32 112.1 1.7 1.5 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 KII60890.1 - 0.0061 17.1 1.1 0.018 15.6 0.1 2.3 3 0 0 3 3 3 1 PH domain TAN PF11640.8 KII60890.1 - 0.048 13.8 2.1 0.099 12.8 0.2 2.1 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair DUF1759 PF03564.15 KII60895.1 - 0.00083 19.3 0.0 0.0012 18.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Sod_Cu PF00080.20 KII60896.1 - 6.2e-18 65.3 0.8 7.8e-18 65.0 0.8 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Peptidase_M13_N PF05649.13 KII60898.1 - 1.2e-59 202.9 0.8 1.5e-32 113.8 0.1 2.3 1 1 1 2 2 2 2 Peptidase family M13 Peptidase_M13 PF01431.21 KII60898.1 - 2.3e-57 193.9 0.2 3.6e-57 193.3 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M13 DUF1542 PF07564.11 KII60898.1 - 0.16 12.1 4.0 0.41 10.8 4.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) FIVAR PF07554.13 KII60898.1 - 5.9 7.7 9.5 14 6.6 3.3 2.5 2 0 0 2 2 2 0 FIVAR domain BHD_3 PF10405.9 KII60899.1 - 5.9e-26 90.7 0.1 4e-25 88.0 0.0 2.0 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 KII60899.1 - 0.039 14.9 5.3 0.072 14.1 0.7 2.9 3 1 0 3 3 3 0 Rad4 beta-hairpin domain 2 GCK PF07802.11 KII60900.1 - 0.013 15.9 0.7 0.013 15.9 0.7 1.8 2 0 0 2 2 2 0 GCK domain EF-hand_10 PF14788.6 KII60900.1 - 0.45 10.4 1.8 4.6 7.2 0.2 2.3 2 0 0 2 2 2 0 EF hand YdjO PF14169.6 KII60902.1 - 0.015 15.0 0.2 0.026 14.3 0.2 1.4 1 0 0 1 1 1 0 Cold-inducible protein YdjO FLYWCH PF04500.16 KII60902.1 - 0.018 15.2 4.7 0.026 14.6 4.7 1.3 1 0 0 1 1 1 0 FLYWCH zinc finger domain TPR_2 PF07719.17 KII60904.1 - 2.1e-09 36.8 3.6 0.0069 16.4 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 KII60904.1 - 3e-07 30.8 1.3 0.00072 20.0 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat FKBP_C PF00254.28 KII60904.1 - 6.4e-06 26.4 0.0 1.6e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_12 PF13424.6 KII60904.1 - 1.3e-05 25.3 0.2 0.029 14.7 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KII60904.1 - 1.5e-05 24.6 5.2 0.55 10.1 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KII60904.1 - 0.00044 20.3 1.5 3.5 8.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 KII60904.1 - 0.00054 20.4 0.6 0.96 10.2 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KII60904.1 - 0.0049 17.1 0.1 0.012 15.8 0.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KII60904.1 - 0.031 15.1 0.2 2.4 9.2 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KII60904.1 - 0.077 13.7 0.0 2.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KII60904.1 - 0.14 12.2 0.4 4.7 7.3 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Prenyltrans PF00432.21 KII60905.1 - 4.5e-27 93.5 4.9 2.2e-13 49.7 0.0 5.6 6 1 0 6 6 6 2 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 KII60905.1 - 0.14 11.2 0.0 1.7 7.7 0.0 2.3 1 1 1 2 2 2 0 Squalene-hopene cyclase N-terminal domain Aconitase_C PF00694.19 KII60906.1 - 9.6e-43 145.7 0.0 1.5e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase PF00330.20 KII60906.1 - 2.3e-33 115.9 0.0 2.8e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Pax7 PF12360.8 KII60906.1 - 0.0099 16.1 0.0 0.025 14.8 0.0 1.8 1 0 0 1 1 1 1 Paired box protein 7 Kelch_6 PF13964.6 KII60908.1 - 2.8e-11 43.3 3.2 0.001 19.2 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII60908.1 - 1.5e-06 27.7 6.2 0.0091 15.6 0.9 4.1 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII60908.1 - 1e-05 25.3 1.6 0.94 9.6 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII60908.1 - 2.3e-05 24.5 1.1 0.013 15.7 0.0 3.0 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII60908.1 - 0.0018 18.2 0.5 0.0087 16.0 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Ras PF00071.22 KII60909.1 - 7.5e-47 158.9 0.0 9.4e-47 158.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII60909.1 - 1.6e-28 99.4 0.0 3e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII60909.1 - 1.2e-07 31.4 0.0 2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KII60909.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KII60909.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Transglut_C PF00927.22 KII60911.1 - 0.0041 17.2 1.3 0.38 10.9 0.1 2.9 2 1 1 3 3 3 2 Transglutaminase family, C-terminal ig like domain polyprenyl_synt PF00348.17 KII60912.1 - 1.1e-50 172.2 0.0 1.5e-50 171.6 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase DDE_1 PF03184.19 KII60913.1 - 8e-09 35.4 0.0 1.7e-08 34.3 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_3 PF01381.22 KII60913.1 - 0.0005 20.1 0.2 0.0012 18.8 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix CENP-B_N PF04218.13 KII60913.1 - 0.00094 18.8 0.1 0.002 17.7 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.6 KII60913.1 - 0.0021 17.8 1.4 0.021 14.6 0.2 2.6 3 0 0 3 3 3 1 Helix-turn-helix domain LacI PF00356.21 KII60913.1 - 0.0029 17.3 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_IclR PF09339.10 KII60913.1 - 0.006 16.4 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_psq PF05225.16 KII60913.1 - 0.0061 16.3 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 KII60913.1 - 0.018 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Crp_2 PF13545.6 KII60913.1 - 0.065 13.2 0.1 0.17 11.9 0.1 1.7 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_24 PF13412.6 KII60913.1 - 0.086 12.4 0.1 0.21 11.2 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TrmB PF01978.19 KII60913.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_49 PF18010.1 KII60913.1 - 0.18 11.7 0.9 3.9 7.5 0.1 2.7 3 0 0 3 3 3 0 Cry35Ab1 HTH C-terminal domain polyprenyl_synt PF00348.17 KII60914.1 - 5.3e-50 169.9 0.0 7.7e-50 169.3 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase Homeodomain PF00046.29 KII60917.1 - 3.2e-19 68.5 3.3 8e-19 67.2 3.3 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KII60917.1 - 0.00065 19.5 1.3 0.0013 18.5 0.2 2.1 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 KII60917.1 - 0.00084 18.8 0.0 0.0019 17.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Ribosomal_L6e PF01159.19 KII60918.1 - 2.4e-33 115.0 0.8 2.4e-33 115.0 0.8 2.0 2 0 0 2 2 2 1 Ribosomal protein L6e Cas_GSU0053 PF09617.10 KII60918.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) Bot1p PF12298.8 KII60919.1 - 0.13 12.4 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein CAP PF00188.26 KII60921.1 - 1.6e-06 29.0 0.3 2.8e-06 28.2 0.3 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.26 KII60922.1 - 3e-11 44.3 0.0 3.7e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family HTH_Tnp_Tc5 PF03221.16 KII60925.1 - 0.0007 19.6 0.0 0.0012 18.9 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF5103 PF17116.5 KII60926.1 - 0.044 13.1 0.1 0.054 12.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5103) DUF2185 PF09951.9 KII60927.1 - 0.044 13.6 0.8 0.076 12.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2185) HEM4 PF02602.15 KII60928.1 - 1.4e-15 57.3 0.0 1.7e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD PUF PF00806.19 KII60929.1 - 2e-13 49.2 0.9 5.1e-05 22.7 0.0 6.4 7 0 0 7 7 7 2 Pumilio-family RNA binding repeat PWI PF01480.17 KII60929.1 - 0.027 14.8 0.0 0.11 12.9 0.0 2.1 1 0 0 1 1 1 0 PWI domain RFC1 PF08519.12 KII60929.1 - 0.053 13.7 0.8 0.21 11.7 0.3 2.3 2 1 0 2 2 2 0 Replication factor RFC1 C terminal domain RIH_assoc PF08454.11 KII60929.1 - 0.11 12.3 1.6 3.8 7.4 0.0 3.6 3 1 0 3 3 3 0 RyR and IP3R Homology associated RST PF12174.8 KII60929.1 - 2.6 8.0 5.9 0.83 9.6 0.5 3.0 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain GATA PF00320.27 KII60932.1 - 2.1e-11 43.2 6.1 4.8e-11 42.1 6.1 1.7 1 0 0 1 1 1 1 GATA zinc finger DUF2318 PF10080.9 KII60932.1 - 0.064 13.4 0.4 0.13 12.4 0.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) zf-C2HE PF16278.5 KII60932.1 - 0.24 11.9 1.0 0.38 11.3 0.1 1.8 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Hexokinase_2 PF03727.16 KII60933.1 - 2.8e-67 226.7 0.1 3.5e-67 226.3 0.1 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII60933.1 - 2.7e-46 158.0 0.0 4.6e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Sortilin_C PF15901.5 KII60934.1 - 7.1e-17 62.3 3.1 7.1e-17 62.3 3.1 2.2 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Ldl_recept_a PF00057.18 KII60934.1 - 1.5e-06 28.3 8.7 1.5e-06 28.3 8.7 4.3 5 0 0 5 5 5 1 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII60934.1 - 0.0004 19.3 0.4 0.0004 19.3 0.4 2.7 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, TMEM131_like PF12371.8 KII60934.1 - 0.13 12.5 1.4 45 4.4 0.1 3.9 3 0 0 3 3 3 0 Transmembrane protein 131-like BNR PF02012.20 KII60934.1 - 4.4 7.7 6.2 6.4 7.2 0.3 3.4 3 0 0 3 3 3 0 BNR/Asp-box repeat zf-CCHC PF00098.23 KII60935.1 - 0.00037 20.4 0.9 0.00037 20.4 0.9 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.6 KII60935.1 - 0.045 13.5 2.6 0.088 12.5 2.6 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger gag-asp_proteas PF13975.6 KII60935.1 - 0.095 13.3 0.0 0.29 11.7 0.0 1.9 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII60935.1 - 0.13 13.0 0.0 0.31 11.7 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.6 KII60935.1 - 1.1 9.0 4.2 0.55 10.0 1.2 2.1 2 0 0 2 2 2 0 Zinc knuckle MLVIN_C PF18697.1 KII60936.1 - 0.0001 22.3 0.1 0.00018 21.5 0.1 1.4 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Shugoshin_C PF07557.11 KII60936.1 - 0.028 14.2 0.1 0.059 13.2 0.1 1.6 1 0 0 1 1 1 0 Shugoshin C terminus DnaJ_C PF01556.18 KII60936.1 - 0.046 13.8 0.0 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 DnaJ C terminal domain IPU_b_solenoid PF18783.1 KII60938.1 - 0.085 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Isopullulanase beta-solenoid repeat MFS_1 PF07690.16 KII60941.1 - 4e-26 91.8 21.4 1e-25 90.4 16.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KII60941.1 - 6.7e-07 28.5 20.9 0.00011 21.3 11.5 2.8 1 1 2 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 KII60941.1 - 0.013 13.8 18.8 0.14 10.4 10.5 3.4 1 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KII60942.1 - 1.8e-28 99.5 18.2 2.6e-28 99.0 18.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KII60942.1 - 3.3e-11 42.7 17.5 4e-11 42.4 13.7 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter DUF1240 PF06836.12 KII60942.1 - 0.24 12.0 0.2 0.24 12.0 0.2 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1240) Thioredoxin_3 PF13192.6 KII60944.1 - 0.0099 15.9 0.1 0.018 15.1 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin domain WD40 PF00400.32 KII60945.1 - 2.4e-24 85.1 8.6 4.1e-05 24.2 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat Sof1 PF04158.14 KII60945.1 - 1.5e-19 70.0 3.9 1.5e-19 70.0 3.9 1.8 2 0 0 2 2 2 1 Sof1-like domain ANAPC4_WD40 PF12894.7 KII60945.1 - 9.4e-07 29.0 0.3 4.3 7.7 0.0 5.1 3 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KII60945.1 - 7.9e-06 25.9 0.2 0.15 11.9 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KII60945.1 - 0.00083 18.8 0.6 0.01 15.2 0.2 2.5 2 1 0 2 2 2 1 WD40-like domain Nup160 PF11715.8 KII60945.1 - 0.021 13.5 0.0 0.041 12.5 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 HPS3_N PF14761.6 KII60945.1 - 0.15 11.6 0.4 18 4.8 0.0 2.7 1 1 2 3 3 3 0 Hermansky-Pudlak syndrome 3 Aldo_ket_red PF00248.21 KII60949.1 - 1.2e-12 47.7 0.0 2.7e-12 46.5 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family DNA_ligase_OB_2 PF14743.6 KII60950.1 - 0.094 12.8 0.1 0.2 11.7 0.1 1.6 1 0 0 1 1 1 0 DNA ligase OB-like domain XG_FTase PF03254.13 KII60950.1 - 0.096 11.3 0.1 0.13 10.9 0.1 1.1 1 0 0 1 1 1 0 Xyloglucan fucosyltransferase Arf PF00025.21 KII60951.1 - 2.2e-24 85.9 0.1 2.4e-24 85.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KII60951.1 - 0.0001 21.8 0.3 0.00019 20.9 0.3 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 KII60951.1 - 0.00018 22.1 0.0 0.00024 21.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KII60951.1 - 0.0029 17.6 0.1 0.0045 17.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 KII60951.1 - 0.0052 17.0 0.2 0.28 11.4 0.2 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KII60951.1 - 0.013 15.6 0.5 0.55 10.3 0.5 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KII60951.1 - 0.016 14.5 1.6 0.063 12.6 1.6 1.8 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 KII60951.1 - 0.054 13.8 1.2 0.32 11.3 1.2 1.8 1 1 0 1 1 1 0 AAA domain Phage-scaffold PF09306.10 KII60951.1 - 0.057 12.8 0.1 0.068 12.5 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein G-alpha PF00503.20 KII60951.1 - 0.068 12.3 0.7 1.3 8.1 0.1 2.1 1 1 1 2 2 2 0 G-protein alpha subunit PduV-EutP PF10662.9 KII60951.1 - 0.094 12.5 0.7 1.2 8.9 0.3 2.2 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 KII60951.1 - 0.1 12.1 0.1 9.4 5.7 0.1 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 KII60951.1 - 0.12 12.1 0.0 0.42 10.3 0.0 1.7 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 KII60951.1 - 0.2 11.9 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Coilin_N PF15862.5 KII60952.1 - 0.045 13.6 0.0 0.056 13.3 0.0 1.2 1 0 0 1 1 1 0 Coilin N-terminus ABC_tran PF00005.27 KII60957.1 - 1.1e-10 42.2 0.0 1.7e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KII60957.1 - 0.0024 17.7 0.9 0.22 11.3 0.3 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KII60957.1 - 0.066 13.0 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dus PF01207.17 KII60958.1 - 9.2e-71 238.5 0.0 1.1e-70 238.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 KII60958.1 - 0.0011 18.3 0.0 0.026 13.8 0.0 2.0 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase HMGL-like PF00682.19 KII60958.1 - 0.013 15.0 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 HMGL-like His_biosynth PF00977.21 KII60958.1 - 0.017 14.6 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein SOR_SNZ PF01680.17 KII60958.1 - 0.019 14.8 0.0 0.67 9.7 0.0 2.1 1 1 1 2 2 2 0 SOR/SNZ family DUF2188 PF09954.9 KII60958.1 - 0.028 14.5 0.0 0.43 10.8 0.0 2.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2188) ThiG PF05690.14 KII60958.1 - 0.067 12.5 0.0 0.092 12.0 0.0 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 KII60958.1 - 0.18 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator NMO PF03060.15 KII60958.1 - 0.19 11.1 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase RRM_1 PF00076.22 KII60959.1 - 1.8e-12 46.9 0.0 2.5e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII60959.1 - 0.12 12.5 0.2 0.24 11.6 0.2 1.6 1 1 0 1 1 1 0 RNA recognition motif ECR1_N PF14382.6 KII60960.1 - 3.1e-07 30.1 0.0 5.2e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.9 KII60960.1 - 0.017 15.8 0.0 0.035 14.7 0.0 1.6 1 0 0 1 1 1 0 Exosome component EXOSC1/CSL4 KH_6 PF15985.5 KII60960.1 - 0.12 12.7 0.7 0.31 11.4 0.7 1.7 1 1 0 1 1 1 0 KH domain GRASP55_65 PF04495.14 KII60961.1 - 6e-52 175.6 0.6 2.8e-39 134.6 0.2 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 KII60961.1 - 9.1e-05 22.7 0.0 0.024 14.9 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KII60961.1 - 0.0022 17.8 0.0 2.4 8.1 0.0 3.1 3 0 0 3 3 3 2 PDZ domain PBP PF01161.20 KII60964.1 - 1.9e-07 31.5 0.0 2.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein EF-hand_7 PF13499.6 KII60965.1 - 7.2e-21 74.4 3.8 6.2e-12 45.8 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KII60965.1 - 1.1e-19 68.4 0.7 9.1e-06 24.9 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KII60965.1 - 8.5e-18 62.7 1.2 3e-06 26.7 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KII60965.1 - 1.7e-10 40.5 3.0 3.6e-07 29.9 0.0 3.4 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KII60965.1 - 2.6e-09 36.2 0.5 0.00019 20.8 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 KII60965.1 - 1.3e-07 31.8 0.1 0.00013 22.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KII60965.1 - 0.00028 21.2 0.3 0.0022 18.3 0.1 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KII60965.1 - 0.012 16.4 0.2 0.085 13.7 0.1 2.0 1 1 1 2 2 2 0 EF-hand domain EF-hand_14 PF17959.1 KII60965.1 - 0.027 14.8 0.9 5.3 7.5 0.2 2.3 1 1 1 2 2 2 0 EF-hand domain GPHH PF16905.5 KII60965.1 - 0.15 11.8 0.0 2.8 7.8 0.0 2.7 3 0 0 3 3 3 0 Voltage-dependent L-type calcium channel, IQ-associated Transglut_core PF01841.19 KII60968.1 - 1.8e-15 57.4 0.3 3.4e-15 56.5 0.3 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_N PF00868.20 KII60968.1 - 5.2e-15 55.8 0.0 1.4e-14 54.5 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.22 KII60968.1 - 0.0033 17.6 0.1 0.011 15.8 0.1 1.9 1 1 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain MG4 PF17789.1 KII60968.1 - 0.044 13.9 0.0 6.4 7.0 0.0 2.7 2 0 0 2 2 2 0 Macroglobulin domain MG4 Peptidase_S24 PF00717.23 KII60969.1 - 1.2e-05 25.2 0.0 2.5e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 Peptidase S24-like TRAPP PF04051.16 KII60970.1 - 1.3e-19 70.4 0.0 1.5e-19 70.2 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Cpn60_TCP1 PF00118.24 KII60971.1 - 1.3e-142 476.0 8.4 1.4e-142 475.8 8.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_S17e PF00833.18 KII60972.1 - 4.1e-53 178.5 0.2 4.9e-53 178.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal S17 UBA PF00627.31 KII60972.1 - 0.11 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 UBA/TS-N domain BAH PF01426.18 KII60975.1 - 1.5e-09 37.8 0.2 4.1e-07 29.9 0.2 2.4 1 1 0 1 1 1 1 BAH domain Pkinase_Tyr PF07714.17 KII60976.1 - 1.8e-31 109.3 0.2 1.6e-29 103.0 0.2 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KII60976.1 - 3.1e-29 102.2 0.1 7.3e-29 100.9 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 KII60976.1 - 0.00037 19.4 0.5 0.00054 18.9 0.1 1.4 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KII60976.1 - 0.001 19.1 0.1 0.0038 17.2 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KII60976.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ANAPC4_WD40 PF12894.7 KII60979.1 - 0.015 15.5 0.1 2.5 8.5 0.0 3.2 1 1 3 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF870 PF05912.11 KII60979.1 - 0.036 14.1 0.0 0.093 12.8 0.0 1.7 1 1 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF870) PetN PF03742.14 KII60979.1 - 0.14 12.1 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 PetN FLYWCH PF04500.16 KII60980.1 - 4.7e-08 33.0 1.2 4.7e-08 33.0 1.2 1.7 2 0 0 2 2 2 1 FLYWCH zinc finger domain WRKY PF03106.15 KII60980.1 - 0.073 13.3 1.6 0.19 12.0 1.6 1.7 1 0 0 1 1 1 0 WRKY DNA -binding domain Gsf2 PF11055.8 KII60982.1 - 0.029 13.2 1.1 0.037 12.8 1.1 1.1 1 0 0 1 1 1 0 Glucose signalling factor 2 FRP PF18032.1 KII60982.1 - 0.082 13.5 0.1 0.14 12.8 0.1 1.4 1 0 0 1 1 1 0 Photoprotection regulator fluorescence recovery protein THAP PF05485.12 KII60983.1 - 0.13 13.2 0.0 0.24 12.3 0.0 1.5 1 0 0 1 1 1 0 THAP domain Oxysterol_BP PF01237.18 KII60984.1 - 2.5e-56 191.1 1.5 8.6e-56 189.4 1.5 1.7 1 1 0 1 1 1 1 Oxysterol-binding protein Y_phosphatase PF00102.27 KII60985.1 - 1.1e-60 205.2 1.8 1.1e-60 205.2 1.8 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 KII60985.1 - 0.012 15.4 0.5 0.067 13.0 0.3 2.3 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KII60985.1 - 0.093 12.7 0.0 0.27 11.2 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family Topoisom_bac PF01131.20 KII60986.1 - 4.6e-85 286.1 0.0 2.8e-84 283.5 0.0 1.9 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 KII60986.1 - 2.2e-15 56.7 0.0 4.2e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Toprim domain Enolase_C PF00113.22 KII60987.1 - 8.2e-150 498.0 0.3 1e-149 497.7 0.3 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KII60987.1 - 1.1e-57 193.8 0.1 2e-57 193.0 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 KII60987.1 - 6.9e-07 29.0 0.0 1.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 KII60987.1 - 0.0036 16.5 0.3 0.0036 16.5 0.3 1.7 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus HDPD PF02924.14 KII60987.1 - 0.025 14.7 0.2 0.05 13.7 0.2 1.4 1 0 0 1 1 1 0 Bacteriophage lambda head decoration protein D Radical_SAM_C PF16199.5 KII60988.1 - 5.2e-24 84.1 0.1 9.6e-24 83.2 0.1 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KII60988.1 - 2.7e-16 60.4 0.1 5.8e-16 59.3 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 KII60988.1 - 1.1e-07 32.1 0.1 2.4e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII60988.1 - 1.8e-05 24.7 0.0 3.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII60988.1 - 0.017 15.6 0.1 0.032 14.7 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Radical_SAM_C PF16199.5 KII60989.1 - 1.5e-27 95.5 0.1 2.9e-27 94.5 0.1 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KII60989.1 - 8.7e-17 62.0 0.0 1.9e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 KII60989.1 - 9e-10 38.8 0.0 2.2e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII60989.1 - 2.7e-05 24.1 0.0 6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII60989.1 - 0.0037 17.7 0.0 0.0076 16.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF4523 PF15023.6 KII60989.1 - 0.017 15.0 0.0 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) AAA PF00004.29 KII60990.1 - 1.1e-39 135.9 0.0 1.9e-39 135.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 KII60990.1 - 7.1e-21 74.0 0.0 2.3e-20 72.4 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 KII60990.1 - 5e-16 58.5 0.9 5e-16 58.5 0.9 1.9 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 KII60990.1 - 3.1e-08 33.3 0.0 4.1e-07 29.7 0.0 2.7 3 0 0 3 3 3 1 AAA+ lid domain RuvB_N PF05496.12 KII60990.1 - 9.9e-06 25.4 0.0 9.3e-05 22.2 0.0 2.5 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 KII60990.1 - 2.2e-05 24.5 0.0 0.00015 21.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 KII60990.1 - 2.2e-05 23.7 0.0 0.00011 21.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 KII60990.1 - 2.5e-05 24.6 0.0 0.0019 18.5 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KII60990.1 - 0.0001 22.3 0.0 0.00032 20.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KII60990.1 - 0.00014 21.6 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 KII60990.1 - 0.00024 20.4 0.0 0.00036 19.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 KII60990.1 - 0.00027 21.4 0.0 0.014 15.8 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KII60990.1 - 0.00045 20.4 0.0 0.0012 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 KII60990.1 - 0.00051 20.6 0.0 0.0013 19.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KII60990.1 - 0.0018 17.9 0.3 1.3 8.5 0.1 2.4 1 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KII60990.1 - 0.0018 18.4 0.0 0.0049 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KII60990.1 - 0.0031 17.3 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KII60990.1 - 0.019 14.5 0.0 0.046 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 KII60990.1 - 0.027 14.2 0.0 0.21 11.3 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain TniB PF05621.11 KII60990.1 - 0.03 13.7 0.0 2.3 7.6 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein Mg_chelatase PF01078.21 KII60990.1 - 0.033 13.6 0.0 0.081 12.3 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KII60990.1 - 0.041 14.3 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 KII60990.1 - 0.054 13.4 0.0 2.3 8.1 0.0 2.4 1 1 1 2 2 2 0 NACHT domain PhoH PF02562.16 KII60990.1 - 0.06 12.8 0.3 0.14 11.6 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.13 KII60990.1 - 0.12 11.7 0.0 2.3 7.5 0.1 2.2 1 1 0 1 1 1 0 KaiC EMP70 PF02990.16 KII60992.1 - 7.5e-11 41.4 0.6 7.9e-11 41.3 0.6 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 Y_phosphatase PF00102.27 KII60993.1 - 2.2e-69 233.6 2.6 3e-69 233.2 2.6 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KII60993.1 - 0.00056 20.1 0.0 0.021 15.0 0.0 2.5 2 0 0 2 2 2 1 Inositol hexakisphosphate SH2 PF00017.24 KII60993.1 - 0.00081 19.4 0.1 0.0021 18.1 0.1 1.8 1 0 0 1 1 1 1 SH2 domain DSPc PF00782.20 KII60993.1 - 0.0041 16.9 0.3 0.017 15.0 0.3 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KII60993.1 - 0.0082 16.1 0.0 0.028 14.4 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family LAGLIDADG_1 PF00961.19 KII60993.1 - 6 7.9 7.7 1.1 10.3 0.8 3.0 3 0 0 3 3 3 0 LAGLIDADG endonuclease Dynamin_M PF01031.20 KII60996.1 - 1.9e-59 201.2 1.0 2.4e-59 200.9 1.0 1.1 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 KII60996.1 - 3.9e-08 33.5 0.1 1e-07 32.2 0.0 1.8 2 0 0 2 2 2 1 Dynamin family PH PF00169.29 KII60996.1 - 0.0075 16.8 0.2 0.019 15.5 0.2 1.7 1 0 0 1 1 1 1 PH domain GDPD_2 PF13653.6 KII60996.1 - 0.075 13.5 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family ZnuA PF01297.17 KII60996.1 - 0.16 11.4 0.1 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic zf-RING_2 PF13639.6 KII60997.1 - 2.4e-10 40.6 8.6 4.9e-10 39.6 8.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KII60997.1 - 7.9e-09 35.7 6.6 2e-08 34.4 6.6 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KII60997.1 - 1.2e-07 31.4 10.1 1.3e-07 31.4 8.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KII60997.1 - 1.4e-07 31.3 7.8 1.4e-07 31.3 7.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KII60997.1 - 9.9e-06 25.3 6.5 2.1e-05 24.3 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KII60997.1 - 4e-05 23.3 5.3 9.7e-05 22.0 5.3 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KII60997.1 - 6.2e-05 22.9 3.5 0.00015 21.7 3.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KII60997.1 - 0.00013 21.8 5.9 0.00028 20.7 5.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KII60997.1 - 0.00013 21.5 6.0 0.00028 20.5 6.0 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 KII60997.1 - 0.0037 17.3 3.6 0.0087 16.1 3.6 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KII60997.1 - 0.0063 16.6 5.7 0.0063 16.6 5.7 1.9 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KII60997.1 - 0.015 15.3 6.5 0.015 15.3 6.5 1.8 2 0 0 2 2 2 0 zinc-RING finger domain zf-Nse PF11789.8 KII60997.1 - 0.056 13.3 4.5 0.11 12.3 4.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 KII60997.1 - 0.18 12.0 9.3 1.6 8.9 9.3 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 KII60997.1 - 0.3 11.3 5.2 0.91 9.7 5.2 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 KII60997.1 - 1.5 9.2 5.3 4.2 7.8 5.3 1.9 1 1 0 1 1 1 0 RING-like domain Ras PF00071.22 KII60998.1 - 4.6e-55 185.6 0.2 5.3e-55 185.4 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII60998.1 - 3.1e-31 108.1 0.1 4.3e-31 107.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII60998.1 - 1.2e-12 47.7 0.1 1.4e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII60998.1 - 0.0003 20.2 0.3 0.00035 20.0 0.3 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KII60998.1 - 0.016 15.1 0.0 0.68 9.8 0.0 2.2 2 1 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 KII60998.1 - 0.017 15.2 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KII60998.1 - 0.018 14.6 0.1 0.055 13.0 0.1 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Ras PF00071.22 KII60999.1 - 3.7e-58 195.7 0.6 4.4e-58 195.5 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII60999.1 - 7.5e-32 110.1 0.1 1.1e-31 109.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII60999.1 - 4.4e-14 52.3 0.0 5.3e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII60999.1 - 3.5e-08 33.1 0.1 4.4e-08 32.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KII60999.1 - 7e-05 22.9 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KII60999.1 - 0.0036 16.7 0.0 0.0061 16.0 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KII60999.1 - 0.0056 16.2 0.1 0.02 14.5 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KII60999.1 - 0.0058 16.5 0.0 0.86 9.5 0.0 2.2 1 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 KII60999.1 - 0.027 14.0 0.0 0.13 11.8 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Flu_M1 PF00598.19 KII60999.1 - 0.051 13.1 0.0 0.072 12.6 0.0 1.2 1 0 0 1 1 1 0 Influenza Matrix protein (M1) Mo-co_dimer PF03404.16 KII61000.1 - 6.5e-37 126.6 0.0 7.8e-37 126.4 0.0 1.1 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Big_7 PF17957.1 KII61000.1 - 0.092 13.5 0.0 0.15 12.9 0.0 1.6 1 1 0 1 1 1 0 Bacterial Ig domain DUF2650 PF10853.8 KII61001.1 - 3.5 7.4 10.1 6.5 6.6 3.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) Homeodomain PF00046.29 KII61004.1 - 2.7e-20 71.9 3.7 2.7e-20 71.9 3.7 1.6 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KII61004.1 - 0.0088 15.9 0.2 0.0088 15.9 0.2 2.0 2 0 0 2 2 2 1 Homeobox KN domain MRP-L20 PF12824.7 KII61004.1 - 0.011 15.9 1.1 0.02 15.0 1.1 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 HTH_28 PF13518.6 KII61004.1 - 0.053 13.7 0.1 0.087 13.0 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain YjeF_N PF03853.15 KII61007.1 - 6.5e-32 110.8 0.0 8.4e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus MitMem_reg PF13012.6 KII61008.1 - 3e-23 82.4 1.1 4.7e-23 81.7 1.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 KII61008.1 - 3.3e-21 75.4 0.0 5.4e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MLVIN_C PF18697.1 KII61009.1 - 0.00026 21.0 0.0 0.00041 20.4 0.0 1.5 1 1 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain ATG11 PF10377.9 KII61009.1 - 0.042 13.9 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 11 Pkinase PF00069.25 KII61010.1 - 1.3e-13 51.0 0.0 1.4e-13 50.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII61010.1 - 2.8e-08 33.4 0.0 3.2e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KII61011.1 - 1.4e-07 31.8 0.1 2.8e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase PF00069.25 KII61011.1 - 6.7e-05 22.4 0.0 8.8e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Tae4 PF14113.6 KII61012.1 - 0.012 15.9 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 Med9 PF07544.13 KII61012.1 - 0.048 13.8 0.2 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 EGF_2 PF07974.13 KII61015.1 - 0.013 15.8 10.4 0.013 15.8 10.4 1.9 2 0 0 2 2 2 0 EGF-like domain OST-HTH PF12872.7 KII61016.1 - 2.7e-08 33.5 0.0 9.2e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 OST-HTH/LOTUS domain DDE_Tnp_IS1595 PF12762.7 KII61017.1 - 2.4e-15 56.9 0.0 2.7e-15 56.7 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII61017.1 - 0.03 14.1 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease zf_ZIC PF18366.1 KII61017.1 - 0.15 12.2 0.6 0.29 11.3 0.6 1.4 1 0 0 1 1 1 0 Zic proteins zinc finger domain Y_phosphatase PF00102.27 KII61019.1 - 8.8e-69 231.6 1.2 1.2e-68 231.2 1.2 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.24 KII61019.1 - 4.1e-07 30.0 0.2 0.0054 16.8 0.1 3.0 3 0 0 3 3 3 2 SH2 domain DSPc PF00782.20 KII61019.1 - 0.0065 16.3 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KII61019.1 - 0.02 14.9 0.0 0.06 13.3 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family zf-UBR PF02207.20 KII61020.1 - 5e-17 61.8 12.2 1.3e-16 60.5 12.2 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) PADR1 PF08063.12 KII61020.1 - 0.0054 16.5 0.4 0.016 15.0 0.4 1.8 1 0 0 1 1 1 1 PADR1 (NUC008) domain ClpS PF02617.17 KII61020.1 - 0.1 12.4 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS DUF816 PF05674.12 KII61021.1 - 0.017 15.0 1.2 0.022 14.7 1.2 1.1 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF816) RecG_N PF17190.4 KII61021.1 - 0.035 14.8 3.4 0.17 12.6 1.1 2.1 1 1 1 2 2 2 0 RecG N-terminal helical domain Dynamin_M PF01031.20 KII61022.1 - 3.6e-61 206.9 1.2 2.2e-59 201.0 1.2 2.2 1 1 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 KII61022.1 - 1.5e-47 161.8 0.0 3.2e-47 160.7 0.0 1.6 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KII61022.1 - 0.0023 18.0 0.0 0.014 15.4 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KII61022.1 - 0.0042 17.5 0.0 0.012 16.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain GDPD_2 PF13653.6 KII61022.1 - 0.015 15.8 0.0 0.037 14.5 0.0 1.7 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family GED PF02212.18 KII61023.1 - 0.1 12.8 0.9 0.16 12.2 0.9 1.3 1 0 0 1 1 1 0 Dynamin GTPase effector domain RT_RNaseH_2 PF17919.1 KII61026.1 - 1.6e-35 121.1 0.2 3e-34 117.1 0.0 3.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61026.1 - 1.6e-34 118.3 0.0 2.4e-33 114.5 0.0 2.7 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII61026.1 - 2.1e-21 76.5 0.1 8.2e-21 74.5 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII61026.1 - 2.3e-20 72.9 0.0 6.7e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61026.1 - 4.2e-18 65.2 0.1 9e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII61026.1 - 1.3e-06 28.1 0.2 3.4e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII61026.1 - 0.0077 16.4 0.2 0.025 14.8 0.0 2.0 2 0 0 2 2 2 1 H2C2 zinc finger RICH PF05062.12 KII61026.1 - 0.23 11.8 3.8 1.1 9.7 1.6 2.6 2 0 0 2 2 2 0 RICH domain Asp_protease_2 PF13650.6 KII61030.1 - 1.6e-06 28.6 0.0 3.5e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII61030.1 - 2.1e-06 28.2 0.0 5.7e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII61030.1 - 0.31 11.2 6.7 0.065 13.3 2.3 2.1 2 0 0 2 2 2 0 Zinc knuckle DUF4749 PF15936.5 KII61032.1 - 0.026 15.6 1.2 0.27 12.4 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4749) PsaA_PsaB PF00223.19 KII61034.1 - 0.011 14.0 0.0 0.014 13.6 0.0 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein SNAP PF14938.6 KII61039.1 - 5.4e-06 26.0 10.6 7.2e-06 25.6 10.6 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Ldl_recept_a PF00057.18 KII61041.1 - 4e-16 58.9 47.8 2.1e-09 37.4 11.0 3.2 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Crisp PF08562.10 KII61041.1 - 0.53 10.9 35.1 1.7 9.3 8.4 3.1 2 1 1 3 3 3 0 Crisp Nucleoplasmin PF03066.15 KII61043.1 - 5.5e-25 87.8 0.2 1.6e-24 86.4 0.0 1.9 2 0 0 2 2 2 1 Nucleoplasmin/nucleophosmin domain NPM1-C PF16276.5 KII61043.1 - 4.6e-08 32.9 0.3 1.1e-07 31.7 0.3 1.6 1 0 0 1 1 1 1 Nucleophosmin C-terminal domain NPL PF17800.1 KII61043.1 - 1.8e-05 25.2 0.0 1.8e-05 25.2 0.0 2.3 2 1 0 2 2 2 1 Nucleoplasmin-like domain SAPS PF04499.15 KII61043.1 - 0.0031 16.4 12.7 0.0041 16.0 12.7 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Nop14 PF04147.12 KII61043.1 - 0.77 7.9 26.0 1 7.5 26.0 1.1 1 0 0 1 1 1 0 Nop14-like family Sortilin-Vps10 PF15902.5 KII61044.1 - 9e-11 41.2 1.0 3.3e-10 39.3 1.0 1.7 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII61044.1 - 7.5e-08 32.9 1.0 1.5e-07 31.9 1.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII61044.1 - 0.0063 16.3 6.7 1.4 9.2 0.1 3.7 3 0 0 3 3 3 1 BNR/Asp-box repeat Sortilin_C PF15901.5 KII61047.1 - 1.4e-10 41.7 0.2 2.1e-10 41.2 0.2 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII61047.1 - 7.9e-09 34.8 0.9 1.1e-08 34.3 0.9 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, TNFR_16_TM PF18422.1 KII61048.1 - 0.019 14.9 2.1 0.041 13.8 2.1 1.6 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain TMEM154 PF15102.6 KII61048.1 - 0.094 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family HEPN_AbiU2 PF18734.1 KII61052.1 - 0.058 12.9 1.7 0.095 12.2 1.7 1.3 1 0 0 1 1 1 0 AbiU2 Replic_Relax PF13814.6 KII61053.1 - 0.13 12.3 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Replication-relaxation zf-UBP PF02148.19 KII61055.1 - 0.048 14.0 1.3 0.086 13.2 1.3 1.4 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein AKAP2_C PF15304.6 KII61055.1 - 0.082 12.2 0.1 0.097 12.0 0.1 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 2 C-terminus Astro_capsid_p PF12226.8 KII61056.1 - 0.046 12.9 0.0 0.046 12.9 0.0 1.0 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RVT_1 PF00078.27 KII61057.1 - 0.00047 19.7 0.0 0.00067 19.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII61058.1 - 1.3e-17 63.7 0.4 2.3e-17 62.8 0.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII61058.1 - 4.8e-05 23.5 0.2 0.00013 22.1 0.0 1.8 2 0 0 2 2 2 1 H2C2 zinc finger zf-3CxxC PF13695.6 KII61058.1 - 0.039 14.4 1.0 0.093 13.2 1.0 1.7 1 1 0 1 1 1 0 Zinc-binding domain rve PF00665.26 KII61058.1 - 0.078 13.2 0.0 0.15 12.2 0.0 1.4 1 1 0 1 1 1 0 Integrase core domain PUA PF01472.20 KII61062.1 - 3.9e-21 74.8 0.9 7.8e-21 73.8 0.9 1.5 1 0 0 1 1 1 1 PUA domain TruB_C_2 PF16198.5 KII61062.1 - 1.6e-11 44.2 0.0 7.1e-11 42.1 0.0 2.1 2 1 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain UPF0113 PF03657.13 KII61062.1 - 0.00012 22.3 0.0 0.00027 21.1 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain DUF1168 PF06658.12 KII61063.1 - 1.6e-18 66.8 8.6 1.6e-18 66.8 8.6 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) NUC PF18510.1 KII61063.1 - 0.13 12.7 6.3 0.17 12.3 6.3 1.2 1 0 0 1 1 1 0 Nuclease domain DUF3490 PF11995.8 KII61063.1 - 1.1 9.0 11.2 1.5 8.6 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) Vma12 PF11712.8 KII61063.1 - 4.1 7.5 5.6 4.7 7.3 5.6 1.3 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Atg14 PF10186.9 KII61063.1 - 6.8 5.7 12.1 8.6 5.3 12.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Acyltransferase PF01553.21 KII61064.1 - 1.7e-14 53.6 0.0 2.6e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase ATR13 PF16829.5 KII61066.1 - 0.031 14.6 0.3 0.24 11.8 0.3 2.6 1 0 0 1 1 1 0 Avirulence protein ATR13, RxLR effector Swi3 PF07962.12 KII61066.1 - 4.1 7.5 5.5 1.3 9.0 0.4 2.8 3 0 0 3 3 3 0 Replication Fork Protection Component Swi3 SEO_C PF14577.6 KII61068.1 - 0.076 12.4 0.0 0.08 12.4 0.0 1.1 1 0 0 1 1 1 0 Sieve element occlusion C-terminus Dynamin_N PF00350.23 KII61069.1 - 0.032 14.3 0.3 0.044 13.8 0.3 1.2 1 0 0 1 1 1 0 Dynamin family RVT_1 PF00078.27 KII61070.1 - 1.9e-11 43.9 0.0 2.1e-11 43.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_IS1595 PF12762.7 KII61072.1 - 3.6e-07 30.3 0.0 1.1e-06 28.7 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII61074.1 - 3.8e-10 39.7 0.0 7.7e-10 38.7 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF2024 PF09630.10 KII61074.1 - 0.024 14.5 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) DDE_3 PF13358.6 KII61076.1 - 1.8e-13 50.4 0.1 2.3e-13 50.1 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3038 PF11237.8 KII61077.1 - 0.02 14.9 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) bZIP_1 PF00170.21 KII61078.1 - 3.2e-12 46.4 8.8 4.8e-12 45.8 8.8 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KII61078.1 - 3.1e-06 27.2 9.8 4.4e-06 26.7 9.5 1.4 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KII61078.1 - 0.017 15.6 7.0 0.025 15.1 7.0 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF5339 PF17274.2 KII61078.1 - 0.057 14.3 0.3 0.096 13.5 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5339) DUF4242 PF14026.6 KII61078.1 - 0.16 12.1 0.4 0.35 11.1 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) Tim44 PF04280.15 KII61079.1 - 0.0014 18.8 0.0 0.0021 18.2 0.0 1.3 1 1 0 1 1 1 1 Tim44-like domain Cpn60_TCP1 PF00118.24 KII61080.1 - 5.6e-158 526.6 7.6 6.5e-158 526.4 7.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SMC_Nse1 PF07574.13 KII61081.1 - 1.1e-12 48.3 0.4 2.3e-12 47.2 0.4 1.6 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 KII61081.1 - 0.00017 21.9 14.4 0.00026 21.2 14.4 1.3 1 0 0 1 1 1 1 RING-like domain Rpr2 PF04032.16 KII61081.1 - 0.0059 16.9 5.9 0.016 15.5 5.9 1.7 1 1 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain C1_1 PF00130.22 KII61081.1 - 0.0079 16.1 8.3 0.0079 16.1 8.3 1.9 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) HTH_57 PF18679.1 KII61081.1 - 0.014 15.7 0.0 0.58 10.5 0.0 2.2 2 0 0 2 2 2 0 ThcOx helix turn helix domain MAGE PF01454.19 KII61081.1 - 0.042 13.6 0.5 1.3 8.6 0.3 2.1 2 0 0 2 2 2 0 MAGE family EcoEI_R_C PF08463.10 KII61081.1 - 0.051 13.7 2.7 0.17 12.0 2.7 1.9 1 1 0 1 1 1 0 EcoEI R protein C-terminal DUF3349 PF11829.8 KII61081.1 - 0.12 13.1 1.0 0.4 11.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) FlaG PF03646.15 KII61081.1 - 0.14 12.4 1.6 0.18 12.0 0.6 1.7 2 0 0 2 2 2 0 FlaG protein DUF4795 PF16043.5 KII61081.1 - 0.18 11.4 2.4 0.35 10.4 2.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) PHD PF00628.29 KII61081.1 - 1.5 8.8 12.3 2.5 8.1 12.3 1.4 1 0 0 1 1 1 0 PHD-finger Daxx PF03344.15 KII61082.1 - 0.11 12.5 0.1 0.14 12.2 0.1 1.1 1 0 0 1 1 1 0 Daxx N-terminal Rassf1C-interacting domain WD40 PF00400.32 KII61083.1 - 0.037 14.9 0.5 0.92 10.5 0.3 2.8 2 0 0 2 2 2 0 WD domain, G-beta repeat Peptidase_C53 PF05550.11 KII61083.1 - 0.067 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Pestivirus Npro endopeptidase C53 BRO1 PF03097.18 KII61084.1 - 1.4e-33 116.3 0.1 1.4e-33 116.3 0.1 1.7 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KII61084.1 - 8.5e-32 110.6 6.8 8.5e-32 110.6 6.8 1.9 2 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV DUF3177 PF11375.8 KII61084.1 - 0.031 14.1 0.1 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3177) COG5 PF10392.9 KII61084.1 - 0.084 13.1 6.1 0.072 13.3 1.5 3.0 3 0 0 3 3 3 0 Golgi transport complex subunit 5 CENP-F_leu_zip PF10473.9 KII61084.1 - 1.5 8.9 4.7 17 5.5 3.9 2.9 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 KII61084.1 - 3.9 7.6 13.6 0.36 11.0 1.8 3.9 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Peptidase_M22 PF00814.25 KII61085.1 - 6.7e-49 167.0 0.0 1.1e-48 166.3 0.0 1.3 1 0 0 1 1 1 1 Glycoprotease family DUF3653 PF12375.8 KII61085.1 - 0.1 12.7 0.0 0.51 10.5 0.0 2.0 2 0 0 2 2 2 0 Phage protein SLM4 PF16818.5 KII61086.1 - 0.0016 18.4 0.5 0.002 18.1 0.5 1.1 1 0 0 1 1 1 1 Protein SLM4 CxC4 PF18717.1 KII61087.1 - 0.062 13.1 0.1 0.069 13.0 0.1 1.1 1 0 0 1 1 1 0 CxC4 like cysteine cluster associated with KDZ transposases TAP42 PF04177.12 KII61088.1 - 4.3e-53 180.5 0.4 5e-53 180.3 0.4 1.0 1 0 0 1 1 1 1 TAP42-like family FragX_IP PF05994.11 KII61091.1 - 2.7e-167 558.4 16.7 3.5e-167 558.0 16.7 1.1 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF4441 PF14536.6 KII61091.1 - 0.003 17.8 1.4 0.017 15.3 1.4 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4441) RasGEF_N_2 PF14663.6 KII61091.1 - 0.059 13.8 0.3 0.23 11.9 0.3 2.0 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain CCG PF02754.16 KII61091.1 - 0.071 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Cysteine-rich domain Endopep_inhib PF16800.5 KII61092.1 - 0.11 12.5 1.3 0.15 12.0 1.3 1.3 1 0 0 1 1 1 0 IseA DL-endopeptidase inhibitor C2 PF00168.30 KII61093.1 - 1.4e-11 44.5 0.0 2.8e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain PsbR PF04725.12 KII61093.1 - 0.034 14.5 0.0 0.073 13.4 0.0 1.5 1 0 0 1 1 1 0 Photosystem II 10 kDa polypeptide PsbR tRNA-synt_1d PF00750.19 KII61094.1 - 6.1e-124 413.5 0.7 1.1e-123 412.6 0.7 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 KII61094.1 - 6.5e-21 74.7 0.0 2e-20 73.2 0.0 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 KII61094.1 - 5.2e-08 33.4 0.0 1.3e-07 32.1 0.0 1.7 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 KII61094.1 - 0.0011 18.4 0.0 0.0021 17.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain EF-hand_8 PF13833.6 KII61094.1 - 0.031 14.1 0.0 40 4.2 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain pair TetR_C_19 PF17924.1 KII61094.1 - 0.16 12.5 0.8 6.7 7.3 0.0 3.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain SRI PF08236.11 KII61095.1 - 0.00098 19.2 1.8 0.001 19.2 1.1 1.5 1 1 1 2 2 2 1 SRI (Set2 Rpb1 interacting) domain LRR_8 PF13855.6 KII61097.1 - 6.1e-22 77.2 27.3 1.4e-10 40.8 5.5 3.3 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KII61097.1 - 8.9e-15 54.6 35.4 1.5e-06 28.4 3.9 4.9 3 2 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KII61097.1 - 1.4e-06 28.0 16.6 5.2e-06 26.1 5.1 2.9 1 1 2 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 KII61097.1 - 0.00012 22.2 27.1 4.4 8.2 1.2 6.6 7 0 0 7 7 7 5 Leucine Rich Repeat LRR_6 PF13516.6 KII61097.1 - 0.023 14.7 25.5 0.21 11.7 0.6 6.0 7 0 0 7 7 7 0 Leucine Rich repeat CSTF_C PF14304.6 KII61097.1 - 0.11 12.0 0.5 31 4.2 0.0 3.8 4 0 0 4 4 4 0 Transcription termination and cleavage factor C-terminal Pkinase_Tyr PF07714.17 KII61098.1 - 6.9e-27 94.4 0.0 1.1e-20 74.0 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KII61098.1 - 9e-26 90.8 0.1 9.9e-21 74.3 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain GrlR PF16518.5 KII61098.1 - 0.15 12.0 0.0 0.35 10.8 0.1 1.6 2 0 0 2 2 2 0 T3SS negative regulator,GrlR DUF2318 PF10080.9 KII61099.1 - 0.0024 17.9 3.1 0.011 15.9 0.4 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2318) DUF1451 PF07295.11 KII61099.1 - 0.0033 17.5 3.7 0.15 12.1 0.2 2.1 2 0 0 2 2 2 2 Zinc-ribbon containing domain zinc_ribbon_6 PF14599.6 KII61099.1 - 0.047 13.7 5.0 0.25 11.4 1.1 2.2 2 0 0 2 2 2 0 Zinc-ribbon PHD PF00628.29 KII61099.1 - 0.25 11.2 8.5 1.1 9.2 1.7 2.3 2 0 0 2 2 2 0 PHD-finger Elf1 PF05129.13 KII61099.1 - 1.5 8.9 11.0 0.96 9.5 0.2 2.9 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like SR1P PF13790.6 KII61099.1 - 9.8 6.4 8.5 0.57 10.3 0.4 2.8 3 0 0 3 3 3 0 SR1 protein RBD PF02196.15 KII61100.1 - 2.3e-05 24.4 0.1 4.3e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Raf-like Ras-binding domain DnaI_N PF07319.11 KII61100.1 - 0.0048 17.5 0.5 0.0099 16.5 0.5 1.5 1 0 0 1 1 1 1 Primosomal protein DnaI N-terminus DUF836 PF05768.14 KII61100.1 - 0.15 12.5 1.5 0.44 11.0 0.2 2.2 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) YIF1 PF03878.15 KII61101.1 - 1.4e-33 116.4 3.4 1.7e-33 116.1 3.4 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 KII61101.1 - 0.0073 16.0 0.1 0.01 15.5 0.1 1.2 1 0 0 1 1 1 1 Yip1 domain Nop53 PF07767.11 KII61102.1 - 4e-08 33.1 6.3 4.3e-08 33.0 6.3 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) PheRS_DBD2 PF18554.1 KII61102.1 - 0.0036 17.3 0.4 0.0091 16.0 0.4 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 2 Muted PF14942.6 KII61102.1 - 0.047 14.0 5.3 0.094 13.1 5.3 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein Mit_KHE1 PF10173.9 KII61102.1 - 0.23 11.5 2.0 0.27 11.3 2.0 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related PRP1_N PF06424.12 KII61102.1 - 0.67 10.4 7.6 1.5 9.2 7.8 1.4 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal GST_C_3 PF14497.6 KII61103.1 - 1e-20 73.8 0.0 1.4e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KII61103.1 - 1.5e-08 34.7 0.0 3e-08 33.8 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KII61103.1 - 7.3e-05 23.0 0.0 0.00015 22.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KII61103.1 - 0.0005 20.0 0.0 0.00095 19.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF5493 PF17597.2 KII61104.1 - 0.12 12.6 3.4 0.17 12.2 3.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5493) HRG PF16954.5 KII61104.1 - 2.7 8.5 9.3 1.5 9.3 4.4 2.5 1 1 1 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene MFS_1 PF07690.16 KII61105.1 - 4.4e-16 58.8 9.1 5e-16 58.6 9.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KII61105.1 - 2.9e-07 29.7 4.1 3.1e-07 29.6 4.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 KII61105.1 - 0.00057 18.3 6.7 0.006 14.9 2.4 2.0 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 KII61105.1 - 0.031 12.7 0.6 0.035 12.5 0.6 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector Deltameth_res PF16020.5 KII61107.1 - 0.31 11.0 1.4 23 5.0 0.1 2.8 2 0 0 2 2 2 0 Deltamethrin resistance C1_1 PF00130.22 KII61108.1 - 3.9e-05 23.4 12.1 7e-05 22.6 12.1 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4686 PF15742.5 KII61108.1 - 0.078 12.1 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) DUF3086 PF11285.8 KII61108.1 - 0.16 11.1 0.1 0.29 10.2 0.1 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3086) CDC37_C PF08564.10 KII61109.1 - 8.1e-16 58.0 0.4 8.1e-16 58.0 0.4 1.7 1 1 1 2 2 2 1 Cdc37 C terminal domain UBM PF14377.6 KII61109.1 - 0.03 13.8 0.2 0.075 12.5 0.2 1.7 1 0 0 1 1 1 0 Ubiquitin binding region Autophagy_N PF03986.13 KII61109.1 - 0.16 11.9 3.8 0.056 13.4 0.7 1.7 2 0 0 2 2 2 0 Autophagocytosis associated protein (Atg3), N-terminal domain Utp11 PF03998.13 KII61110.1 - 6.6e-26 91.7 33.8 2.7e-23 83.2 12.8 2.1 1 1 1 2 2 2 2 Utp11 protein TRPM_tetra PF16519.5 KII61110.1 - 0.0089 16.1 3.9 0.019 15.0 3.9 1.6 1 0 0 1 1 1 1 Tetramerisation domain of TRPM FlaC_arch PF05377.11 KII61110.1 - 0.077 13.4 2.8 0.077 13.4 2.8 2.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) KxDL PF10241.9 KII61110.1 - 0.19 12.0 12.4 0.25 11.6 8.6 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF16 PF01519.16 KII61110.1 - 0.53 10.8 11.2 1 9.9 11.0 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF1366 PF07104.11 KII61110.1 - 0.79 9.4 7.7 1.4 8.6 7.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1366) FlxA PF14282.6 KII61110.1 - 2.4 8.2 11.9 5.2 7.1 11.9 1.7 1 1 0 1 1 1 0 FlxA-like protein YtxH PF12732.7 KII61110.1 - 2.9 8.5 7.3 23 5.6 7.2 2.6 1 1 0 1 1 1 0 YtxH-like protein XhlA PF10779.9 KII61110.1 - 4.2 7.7 10.6 0.62 10.3 5.3 2.3 2 0 0 2 2 2 0 Haemolysin XhlA DUF2756 PF10956.8 KII61110.1 - 6.3 7.4 10.1 0.53 10.8 1.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2756) Aa_trans PF01490.18 KII61111.1 - 4.1e-41 141.1 54.4 4.6e-41 140.9 54.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KII61111.1 - 2.6e-07 30.0 47.8 4.3e-07 29.3 47.8 1.4 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Med26 PF08711.11 KII61112.1 - 5.4e-09 35.9 2.1 9.6e-09 35.1 2.1 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Speriolin_C PF15059.6 KII61113.1 - 0.045 13.9 0.7 0.068 13.3 0.7 1.4 1 1 0 1 1 1 0 Speriolin C-terminus WAK_assoc PF14380.6 KII61114.1 - 0.067 13.9 2.8 0.15 12.8 2.8 1.6 1 0 0 1 1 1 0 Wall-associated receptor kinase C-terminal Lin-8 PF03353.15 KII61114.1 - 0.48 9.9 14.4 0.59 9.6 14.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PA26 PF04636.13 KII61114.1 - 0.8 8.6 7.6 0.97 8.3 7.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Nop14 PF04147.12 KII61114.1 - 7 4.7 28.4 8.2 4.5 28.4 1.1 1 0 0 1 1 1 0 Nop14-like family WD40 PF00400.32 KII61115.1 - 4.9e-27 93.7 15.5 6.2e-07 30.0 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII61115.1 - 3.7e-09 36.8 0.0 0.0024 18.1 0.0 4.6 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain MFS_1_like PF12832.7 KII61116.1 - 1.3e-51 175.6 16.9 1.6e-51 175.4 16.9 1.0 1 0 0 1 1 1 1 MFS_1 like family Rab_bind PF16704.5 KII61117.1 - 0.00029 20.8 0.4 0.00029 20.8 0.4 3.0 3 0 0 3 3 3 1 Rab binding domain PuR_N PF09182.10 KII61117.1 - 0.054 13.4 0.1 0.19 11.7 0.1 2.0 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal Phospholip_A2_2 PF05826.12 KII61117.1 - 0.056 13.7 1.5 0.33 11.2 0.1 2.6 2 0 0 2 2 2 0 Phospholipase A2 Lipase_GDSL PF00657.22 KII61117.1 - 0.18 11.7 4.1 0.26 11.2 0.3 2.6 2 1 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase CxxCxxCC PF03692.15 KII61117.1 - 0.21 12.3 0.5 0.66 10.7 0.5 1.8 1 0 0 1 1 1 0 Putative zinc- or iron-chelating domain T3SSipB PF16535.5 KII61117.1 - 0.46 11.0 11.9 4.6 7.7 0.4 2.5 2 1 0 2 2 2 0 Type III cell invasion protein SipB DUF1192 PF06698.11 KII61117.1 - 0.66 10.1 6.3 22 5.2 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF948 PF06103.11 KII61117.1 - 1.9 8.8 9.7 13 6.1 0.2 4.1 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.12 KII61117.1 - 2.4 8.8 22.8 2.9 8.6 2.3 5.5 4 2 2 6 6 6 0 SlyX Na_K-ATPase PF00287.18 KII61118.1 - 8e-09 35.1 0.6 0.00063 19.0 0.3 3.2 1 1 2 3 3 3 3 Sodium / potassium ATPase beta chain DUF2140 PF09911.9 KII61118.1 - 0.16 11.5 0.1 0.99 8.9 0.1 2.0 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) Sortilin_C PF15901.5 KII61119.1 - 5.7e-18 65.8 1.8 5.7e-18 65.8 1.8 2.4 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII61119.1 - 5.1e-06 25.5 0.0 0.0043 15.9 0.0 3.3 2 2 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII61119.1 - 0.00066 19.3 6.4 1.2 9.4 0.2 4.6 4 0 0 4 4 4 2 BNR/Asp-box repeat NUP214 PF16755.5 KII61119.1 - 0.011 15.0 0.6 0.011 15.0 0.6 1.7 2 0 0 2 2 2 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 BNR_6 PF15899.5 KII61119.1 - 0.07 13.2 0.1 0.07 13.2 0.1 3.1 3 0 0 3 3 3 0 BNR-Asp box repeat Toxin_24 PF08094.11 KII61119.1 - 0.26 11.1 3.6 0.48 10.3 3.6 1.4 1 0 0 1 1 1 0 Conotoxin TVIIA/GS family DDE_3 PF13358.6 KII61121.1 - 1e-14 54.5 0.0 1.4e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Aldo_ket_red PF00248.21 KII61122.1 - 4.6e-24 85.1 0.0 5.6e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Corona_S2 PF01601.16 KII61123.1 - 0.0011 17.5 0.0 0.0013 17.4 0.0 1.0 1 0 0 1 1 1 1 Coronavirus S2 glycoprotein Arc_PepC_II PF06847.11 KII61123.1 - 0.12 12.9 3.5 0.28 11.7 3.5 1.8 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II DUF3517 PF12030.8 KII61124.1 - 0.064 12.2 0.1 0.1 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3517) Shisa PF13908.6 KII61125.1 - 0.0091 16.3 0.0 0.0093 16.2 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF5527 PF17665.1 KII61125.1 - 0.15 11.6 1.6 0.21 11.1 1.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Adeno_E3 PF06040.11 KII61125.1 - 0.23 11.7 3.2 0.32 11.2 3.2 1.2 1 0 0 1 1 1 0 Adenovirus E3 protein TMEM154 PF15102.6 KII61125.1 - 0.23 11.4 0.1 0.31 10.9 0.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family NCU-G1 PF15065.6 KII61125.1 - 0.52 9.2 1.3 0.68 8.9 1.3 1.2 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 Aldo_ket_red PF00248.21 KII61126.1 - 0.0001 21.7 0.0 0.0001 21.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family ODV-E18 PF10717.9 KII61129.1 - 3.3 7.6 5.8 1.1 9.1 1.4 2.1 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF5075 PF16825.5 KII61131.1 - 0.045 13.5 1.1 0.077 12.7 1.1 1.3 1 0 0 1 1 1 0 IGP family C-type lectin domain Integrase_H2C2 PF17921.1 KII61135.1 - 8.4e-13 48.2 0.4 2.9e-12 46.5 0.1 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII61135.1 - 4.1e-06 27.0 0.0 7.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII61135.1 - 0.00022 21.4 0.0 0.00059 20.0 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger DUF4596 PF15363.6 KII61135.1 - 0.1 12.8 0.8 0.98 9.7 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) RVP PF00077.20 KII61136.1 - 0.051 13.9 0.2 0.41 11.0 0.2 2.1 1 1 0 2 2 2 0 Retroviral aspartyl protease EB1 PF03271.17 KII61136.1 - 0.067 13.4 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 EB1-like C-terminal motif DUF948 PF06103.11 KII61140.1 - 0.18 12.1 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) zf-CCHC PF00098.23 KII61141.1 - 1.2 9.3 5.8 2.5 8.3 5.8 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF1031 PF06275.11 KII61142.1 - 3.5 7.9 7.1 2.6 8.4 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) RXLR PF16810.5 KII61144.1 - 0.039 14.4 0.5 15 6.0 0.0 2.7 1 1 1 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity DUF2615 PF11027.8 KII61144.1 - 0.065 13.4 0.6 0.21 11.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) LAGLIDADG_1 PF00961.19 KII61144.1 - 0.16 13.0 2.4 0.51 11.3 2.0 2.1 2 0 0 2 2 2 0 LAGLIDADG endonuclease SNARE PF05739.19 KII61144.1 - 0.16 12.0 0.4 0.39 10.8 0.4 1.6 1 0 0 1 1 1 0 SNARE domain Pox_A14 PF05767.12 KII61145.1 - 0.38 10.9 2.9 12 6.1 0.2 2.9 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF508 PF04370.12 KII61146.1 - 0.059 13.1 0.1 0.089 12.5 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF508) SNAP PF14938.6 KII61147.1 - 1.3e-09 37.9 15.9 4.6e-07 29.5 2.8 2.0 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP PaREP1 PF05942.11 KII61147.1 - 0.94 9.4 4.3 1.8 8.5 0.5 2.7 3 0 0 3 3 3 0 Archaeal PaREP1/PaREP8 family DUF5314 PF17241.2 KII61148.1 - 0.034 13.8 0.1 0.042 13.5 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5314) Sortilin_C PF15901.5 KII61149.1 - 5.5e-15 56.1 1.8 1e-14 55.2 1.8 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII61149.1 - 1.5e-11 43.7 0.2 4.9e-07 28.9 0.1 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII61149.1 - 1.4e-05 24.4 0.2 1.4 9.3 0.0 3.9 3 0 0 3 3 3 2 BNR/Asp-box repeat SH2 PF00017.24 KII61150.1 - 9.5e-05 22.4 0.1 0.00015 21.8 0.1 1.3 1 0 0 1 1 1 1 SH2 domain Integrin_beta PF00362.18 KII61151.1 - 2.1e-19 70.2 0.0 3.5e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.3 KII61151.1 - 0.0089 15.7 2.2 0.017 14.9 2.2 1.5 1 0 0 1 1 1 1 Integrin plexin domain PSI PF01437.25 KII61151.1 - 0.013 16.1 0.5 0.022 15.3 0.5 1.4 1 0 0 1 1 1 0 Plexin repeat Kelch_6 PF13964.6 KII61152.1 - 6.4e-22 77.0 16.5 0.00057 20.1 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KII61152.1 - 2.7e-17 62.1 10.5 0.0013 18.3 0.1 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII61152.1 - 2.4e-16 59.4 13.3 0.00066 19.6 0.0 5.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KII61152.1 - 7.9e-16 57.9 3.1 0.003 17.8 0.0 6.9 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII61152.1 - 2.8e-13 49.5 12.1 0.038 14.0 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KII61152.1 - 1.3e-10 40.8 13.8 0.019 14.9 0.1 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KII61153.1 - 1.5e-22 79.1 23.1 9.7e-09 35.2 0.1 6.5 5 2 1 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII61153.1 - 4.2e-15 55.6 16.3 8.1e-07 29.2 0.0 6.4 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII61153.1 - 6.8e-14 51.6 19.1 0.0032 17.4 0.1 6.2 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII61153.1 - 1e-11 44.2 15.9 6.9e-05 22.4 0.0 6.3 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII61153.1 - 5e-07 29.6 20.5 0.025 14.6 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 KII61153.1 - 0.0038 17.1 18.3 0.15 12.1 0.0 5.8 6 1 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 KII61154.1 - 1.7e-07 31.3 1.4 2.9e-05 24.2 0.2 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII61154.1 - 4.9e-05 23.1 0.3 0.00062 19.6 0.2 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 KII61154.1 - 7.3e-05 22.3 0.2 0.0034 17.0 0.1 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 KII61154.1 - 0.014 15.6 0.4 0.055 13.8 0.1 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_4 PF13418.6 KII61154.1 - 0.079 13.0 2.6 1 9.4 0.5 2.7 2 2 0 2 2 2 0 Galactose oxidase, central domain ZapD PF07072.11 KII61154.1 - 0.24 11.1 0.0 0.31 10.8 0.0 1.1 1 0 0 1 1 1 0 Cell division protein Kelch_6 PF13964.6 KII61155.1 - 2.7e-13 49.7 4.9 6e-05 23.2 0.2 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII61155.1 - 1.9e-09 37.4 1.4 0.0013 18.7 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII61155.1 - 6.4e-07 29.2 3.5 0.00021 21.2 0.3 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 KII61155.1 - 1.5e-05 24.5 5.8 0.014 14.9 0.5 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII61155.1 - 2.9e-05 23.8 1.1 1.2 9.3 0.1 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII61155.1 - 8.5e-05 22.7 5.5 0.32 11.3 0.0 3.8 4 1 0 4 4 4 2 Galactose oxidase, central domain DUF4395 PF14340.6 KII61155.1 - 0.09 13.1 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4395) Kelch_6 PF13964.6 KII61156.1 - 7.7e-13 48.2 5.3 2.6e-05 24.3 0.2 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII61156.1 - 3.4e-11 42.5 9.8 3e-05 23.5 0.2 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII61156.1 - 1e-10 41.4 7.1 0.00038 20.4 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KII61156.1 - 1.3e-09 37.6 4.4 0.0056 16.6 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII61156.1 - 1.3e-09 38.1 1.0 0.00016 21.9 0.0 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KII61156.1 - 8.1e-07 29.0 5.8 0.00086 19.3 0.0 3.3 3 1 0 3 3 3 2 Galactose oxidase, central domain DDE_3 PF13358.6 KII61158.1 - 1.7e-25 89.5 0.0 2.7e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII61158.1 - 8.1e-07 28.7 0.1 7e-05 22.5 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 KII61158.1 - 1.8e-06 28.5 0.0 0.00036 21.1 0.0 2.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 KII61158.1 - 1.1e-05 25.3 0.2 0.00027 20.9 0.1 2.4 2 0 0 2 2 2 1 Winged helix-turn helix HTH_33 PF13592.6 KII61158.1 - 1.4e-05 24.7 0.0 0.0001 21.9 0.0 2.3 3 0 0 3 3 3 1 Winged helix-turn helix PAX PF00292.18 KII61158.1 - 2e-05 24.5 0.1 3.7e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 'Paired box' domain DUF1323 PF07037.11 KII61158.1 - 0.00038 20.8 0.5 0.011 16.1 0.0 2.9 3 1 1 4 4 4 1 Putative transcription regulator (DUF1323) CENP-B_N PF04218.13 KII61158.1 - 0.0011 18.6 0.1 0.0036 16.9 0.1 1.9 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain TrmB PF01978.19 KII61158.1 - 0.024 14.5 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Transposase_1 PF01359.18 KII61158.1 - 0.038 13.8 0.0 0.084 12.7 0.0 1.5 1 0 0 1 1 1 0 Transposase (partial DDE domain) HTH_28 PF13518.6 KII61158.1 - 0.042 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII61158.1 - 0.075 13.3 3.0 0.15 12.4 0.1 2.6 3 0 0 3 3 3 0 Transposase DUF4093 PF13331.6 KII61158.1 - 0.1 13.0 0.1 1.4 9.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4093) Kelch_6 PF13964.6 KII61159.1 - 1e-14 54.2 13.0 0.012 15.9 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KII61159.1 - 6.7e-13 48.0 14.7 0.0061 16.1 0.1 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KII61159.1 - 1.7e-06 27.9 17.0 0.095 12.7 0.1 6.2 5 2 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII61159.1 - 1.2e-05 25.2 6.6 0.0031 17.5 0.1 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 KII61159.1 - 0.00012 22.3 8.4 0.21 11.9 0.0 6.2 6 1 0 6 6 6 1 Galactose oxidase, central domain Kelch_2 PF07646.15 KII61159.1 - 0.0045 16.9 15.0 0.16 12.0 0.1 6.3 6 2 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 KII61160.1 - 5.6e-15 54.6 2.5 4.6e-07 29.3 0.2 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 KII61160.1 - 6.5e-12 45.3 4.7 1.6e-05 25.0 0.3 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII61160.1 - 4.1e-09 36.0 3.7 0.00085 19.2 0.4 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII61160.1 - 8.2e-08 32.1 0.9 0.00088 19.2 0.1 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII61160.1 - 2.7e-05 24.0 5.4 0.0011 18.9 0.6 2.4 2 1 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII61160.1 - 0.012 15.9 0.8 3.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_3 PF13415.6 KII61161.1 - 0.01 16.1 1.9 0.089 13.1 0.1 2.5 1 1 1 2 2 2 0 Galactose oxidase, central domain Kelch_4 PF13418.6 KII61161.1 - 0.013 15.5 1.3 0.029 14.4 0.9 1.8 1 1 1 2 2 2 0 Galactose oxidase, central domain NOC3p PF07540.11 KII61162.1 - 0.039 14.4 0.1 0.081 13.4 0.1 1.6 1 1 0 1 1 1 0 Nucleolar complex-associated protein HEPN PF05168.14 KII61162.1 - 0.1 12.7 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 HEPN domain Kelch_6 PF13964.6 KII61163.1 - 2.6e-25 87.8 13.6 1.7e-07 31.3 0.1 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII61163.1 - 2e-17 63.0 17.0 9.6e-08 32.1 0.1 6.5 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII61163.1 - 1.5e-16 59.7 17.5 3.2e-05 23.4 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII61163.1 - 5.5e-16 58.3 18.5 0.00067 19.6 0.2 6.3 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII61163.1 - 1.8e-11 43.7 15.6 0.001 19.0 0.1 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KII61163.1 - 0.00011 22.1 18.4 0.037 14.0 0.0 6.2 6 1 0 6 6 6 3 Kelch motif DDE_3 PF13358.6 KII61164.1 - 6.5e-18 64.9 0.0 7.1e-18 64.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII61165.1 - 0.0055 16.9 0.2 0.011 16.0 0.2 1.5 1 0 0 1 1 1 1 Transposase CENP-B_N PF04218.13 KII61165.1 - 0.0083 15.7 0.6 0.88 9.3 0.0 2.8 3 0 0 3 3 3 2 CENP-B N-terminal DNA-binding domain AAA-ATPase_like PF09820.9 KII61165.1 - 0.017 14.5 1.3 0.022 14.2 1.3 1.1 1 0 0 1 1 1 0 Predicted AAA-ATPase Kelch_6 PF13964.6 KII61166.1 - 5.8e-12 45.4 10.0 0.0011 19.2 0.2 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 KII61166.1 - 1.9e-09 37.4 9.6 0.00091 19.2 0.0 4.7 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII61166.1 - 2.1e-08 33.6 7.3 0.087 12.4 0.1 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 KII61166.1 - 3.4e-05 23.7 7.5 0.063 13.3 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 KII61166.1 - 0.00055 20.1 7.5 3.5 8.0 0.0 4.9 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_2 PF07646.15 KII61166.1 - 0.0016 18.3 8.1 0.53 10.3 0.2 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 KII61167.1 - 3.5e-27 94.2 14.9 1.9e-05 24.5 0.0 6.2 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 KII61167.1 - 3.1e-26 90.7 20.0 3.7e-05 23.8 0.1 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII61167.1 - 1.8e-18 66.4 8.6 0.00027 21.1 0.1 6.7 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII61167.1 - 1.3e-16 59.9 27.1 0.00027 20.4 0.1 7.0 6 1 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 KII61167.1 - 5e-12 45.5 18.6 0.0032 17.4 0.2 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KII61167.1 - 6.6e-07 29.1 11.9 0.064 13.3 0.1 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 KII61168.1 - 3.6e-05 23.9 0.7 0.21 11.9 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 KII61168.1 - 0.00071 19.1 0.5 0.83 9.3 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII61168.1 - 0.0088 16.3 0.1 0.059 13.7 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 KII61168.1 - 0.027 14.5 6.0 0.061 13.3 2.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 KII61168.1 - 0.059 13.4 3.6 0.71 9.9 0.1 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF815 PF05673.13 KII61168.1 - 0.14 11.3 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Kelch_6 PF13964.6 KII61169.1 - 2.6e-13 49.7 4.4 9.8e-05 22.5 0.2 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII61169.1 - 1.6e-10 40.7 4.2 0.00011 22.1 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII61169.1 - 3e-10 40.1 1.9 0.0049 17.1 0.2 3.5 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII61169.1 - 3.4e-09 36.6 3.5 0.012 15.6 0.1 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII61169.1 - 4.2e-07 29.5 5.0 0.0022 17.5 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII61169.1 - 7.9e-07 28.8 1.9 0.36 10.9 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Rep_fac_C PF08542.11 KII61170.1 - 0.055 13.9 0.0 0.068 13.6 0.0 1.2 1 0 0 1 1 1 0 Replication factor C C-terminal domain Asp_protease_2 PF13650.6 KII61172.1 - 0.014 16.0 0.0 0.024 15.3 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease RuvC_1 PF18516.1 KII61172.1 - 0.1 11.8 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 RuvC nuclease domain AlgF PF11182.8 KII61175.1 - 0.0026 17.6 0.0 0.0034 17.2 0.0 1.1 1 0 0 1 1 1 1 Alginate O-acetyl transferase AlgF FAM150 PF15129.6 KII61177.1 - 0.0011 19.1 0.8 0.0014 18.8 0.1 1.5 2 0 0 2 2 2 1 FAM150 family DDE_Tnp_IS1595 PF12762.7 KII61178.1 - 3.8e-15 56.2 0.2 8.4e-15 55.1 0.0 1.6 2 0 0 2 2 2 1 ISXO2-like transposase domain RT_RNaseH_2 PF17919.1 KII61179.1 - 5.5e-05 23.1 0.0 7.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Ldl_recept_a PF00057.18 KII61180.1 - 1.2e-33 115.0 135.7 2e-07 31.1 9.6 8.4 6 1 1 8 8 8 7 Low-density lipoprotein receptor domain class A SPRY PF00622.28 KII61180.1 - 0.28 11.3 0.0 0.28 11.3 0.0 2.6 3 0 0 3 3 3 0 SPRY domain RVT_1 PF00078.27 KII61181.1 - 3e-16 59.6 0.0 5e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MULE PF10551.9 KII61182.1 - 7.3e-06 26.3 0.2 1.5e-05 25.3 0.2 1.6 1 0 0 1 1 1 1 MULE transposase domain rve PF00665.26 KII61185.1 - 8e-06 26.0 0.0 1.4e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII61185.1 - 0.00038 20.2 0.0 0.00092 19.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain HTH_Tnp_Tc5 PF03221.16 KII61190.1 - 7.6e-10 38.7 0.0 2.8e-09 36.9 0.0 2.0 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 KII61190.1 - 5.2e-07 29.2 1.0 1.2e-06 28.1 0.7 1.7 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.20 KII61190.1 - 0.013 15.8 0.3 0.031 14.6 0.1 1.8 1 1 0 1 1 1 0 Transposase HTH_23 PF13384.6 KII61190.1 - 0.038 13.8 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF2749 PF10907.8 KII61190.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) Kelch_6 PF13964.6 KII61191.1 - 1.2e-24 85.7 18.6 5.4e-06 26.5 0.2 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII61191.1 - 3.4e-18 65.4 20.7 2.7e-05 24.1 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KII61191.1 - 1.7e-14 53.7 17.3 0.0031 17.8 0.2 6.2 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII61191.1 - 1.9e-14 52.9 16.9 7.5e-06 25.4 0.1 5.9 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KII61191.1 - 8.9e-12 44.5 11.9 0.0011 18.9 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII61191.1 - 5.1e-11 42.3 13.8 0.006 16.5 0.2 5.3 5 0 0 5 5 5 4 Kelch motif TcdA_TcdB_pore PF12920.7 KII61195.1 - 0.15 10.2 0.0 0.15 10.2 0.0 1.0 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain LPD11 PF18824.1 KII61197.1 - 0.09 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 11 rve PF00665.26 KII61198.1 - 1.4e-12 47.8 0.0 1.8e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII61198.1 - 0.0062 16.3 0.1 0.018 14.8 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 KII61199.1 - 7.6e-19 67.6 0.0 1e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61199.1 - 9.1e-12 45.2 0.0 1.4e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-RING_7 PF02591.15 KII61200.1 - 0.1 12.8 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 C4-type zinc ribbon domain rve PF00665.26 KII61201.1 - 3.1e-07 30.6 0.0 3.6e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 KII61202.1 - 1.6e-35 121.1 0.2 3e-34 117.1 0.0 3.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61202.1 - 1.6e-34 118.3 0.0 2.4e-33 114.5 0.0 2.7 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII61202.1 - 2.1e-21 76.5 0.1 8.2e-21 74.5 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII61202.1 - 2.3e-20 72.9 0.0 6.7e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61202.1 - 4.2e-18 65.2 0.1 9e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII61202.1 - 1.3e-06 28.1 0.2 3.4e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII61202.1 - 0.0077 16.4 0.2 0.025 14.8 0.0 2.0 2 0 0 2 2 2 1 H2C2 zinc finger RICH PF05062.12 KII61202.1 - 0.23 11.8 3.8 1.1 9.7 1.6 2.6 2 0 0 2 2 2 0 RICH domain DDE_3 PF13358.6 KII61204.1 - 7e-11 42.1 0.1 9.5e-11 41.6 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII61205.1 - 6.7e-10 38.5 0.8 2.1e-08 33.7 0.0 2.6 3 0 0 3 3 2 1 Homeodomain-like domain HTH_28 PF13518.6 KII61205.1 - 6e-08 32.7 0.1 1.3e-07 31.6 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_33 PF13592.6 KII61205.1 - 8.1e-06 25.4 0.0 1.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.18 KII61205.1 - 1.2e-05 25.2 0.3 1.8e-05 24.6 0.3 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.6 KII61205.1 - 1.6e-05 24.8 0.0 3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 KII61205.1 - 6.5e-05 22.3 0.4 0.2 11.1 0.0 3.3 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 HTH_50 PF18024.1 KII61205.1 - 8.1e-05 22.2 0.1 0.00019 21.0 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 KII61205.1 - 9.2e-05 21.9 0.0 0.00023 20.6 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_32 PF13565.6 KII61205.1 - 0.00025 21.6 0.0 0.0026 18.3 0.0 2.2 1 1 1 2 2 2 1 Homeodomain-like domain HTH_11 PF08279.12 KII61205.1 - 0.0004 20.3 0.5 0.076 13.0 0.3 2.3 2 0 0 2 2 2 1 HTH domain KORA PF16509.5 KII61205.1 - 0.00054 20.2 0.2 0.00077 19.7 0.2 1.4 1 0 0 1 1 1 1 TrfB plasmid transcriptional repressor TrmB PF01978.19 KII61205.1 - 0.0015 18.4 0.1 0.0045 16.8 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB CENP-B_N PF04218.13 KII61205.1 - 0.0031 17.1 2.1 0.0036 16.9 0.6 1.9 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_3 PF01381.22 KII61205.1 - 0.0053 16.8 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix Sigma70_r4_2 PF08281.12 KII61205.1 - 0.0078 15.9 0.0 0.022 14.4 0.0 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 DDE_3 PF13358.6 KII61205.1 - 0.0084 15.9 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease TnsD PF15978.5 KII61205.1 - 0.0091 15.0 0.6 0.01 14.9 0.6 1.2 1 0 0 1 1 1 1 Tn7-like transposition protein D Sigma70_r4 PF04545.16 KII61205.1 - 0.01 15.3 0.1 0.022 14.3 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Tnp_1 PF01527.20 KII61205.1 - 0.012 16.0 0.1 0.067 13.5 0.1 2.0 1 1 1 2 2 2 0 Transposase HTH_Crp_2 PF13545.6 KII61205.1 - 0.031 14.3 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII61205.1 - 0.048 13.9 0.1 0.11 12.7 0.1 1.7 1 0 0 1 1 1 0 Transposase MarR_2 PF12802.7 KII61205.1 - 0.07 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_1 PF00126.27 KII61205.1 - 0.086 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_8 PF02954.19 KII61205.1 - 0.095 12.5 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_38 PF13936.6 KII61205.1 - 0.11 12.3 0.7 0.25 11.1 0.7 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Bot1p PF12298.8 KII61205.1 - 0.12 12.5 0.8 1.6 8.8 0.1 2.1 2 0 0 2 2 2 0 Eukaryotic mitochondrial regulator protein YdaS_antitoxin PF15943.5 KII61205.1 - 0.13 12.2 0.1 2.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_30 PF13556.6 KII61205.1 - 0.14 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain RT_RNaseH_2 PF17919.1 KII61207.1 - 0.0033 17.4 0.1 0.0067 16.4 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII61207.1 - 0.013 15.0 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotrans_gag PF03732.17 KII61209.1 - 0.0057 16.9 0.2 0.0087 16.3 0.2 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein DUF2971 PF11185.8 KII61209.1 - 0.052 14.7 0.2 0.1 13.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2971) HTH_Tnp_ISL3 PF13542.6 KII61210.1 - 0.0023 17.3 0.4 0.016 14.6 0.1 2.4 2 2 1 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 TrmB PF01978.19 KII61210.1 - 0.045 13.6 0.0 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF4026 PF13218.6 KII61212.1 - 0.1 11.6 0.2 0.12 11.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4026) Exog_C PF18026.1 KII61213.1 - 0.056 13.5 0.1 0.15 12.1 0.1 1.7 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain DDE_Tnp_IS1595 PF12762.7 KII61214.1 - 0.003 17.6 0.0 0.0042 17.1 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain HTH_5 PF01022.20 KII61215.1 - 0.0035 17.2 0.5 0.096 12.6 0.1 2.5 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family GerE PF00196.19 KII61215.1 - 0.015 14.9 0.2 0.3 10.7 0.1 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_23 PF13384.6 KII61215.1 - 0.021 14.6 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain SH2 PF00017.24 KII61216.1 - 0.00024 21.1 0.1 0.00042 20.4 0.1 1.4 1 0 0 1 1 1 1 SH2 domain CppA_N PF14506.6 KII61216.1 - 0.071 13.2 0.1 0.1 12.7 0.1 1.3 1 1 0 1 1 1 0 CppA N-terminal DUF5301 PF17225.3 KII61216.1 - 0.14 12.6 1.7 7.5 7.1 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5300) DUF3134 PF11332.8 KII61221.1 - 0.14 12.5 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3134) Kunitz_BPTI PF00014.23 KII61221.1 - 1.8 8.9 8.9 6.5 7.1 0.5 2.6 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain gag-asp_proteas PF13975.6 KII61222.1 - 0.01 16.3 0.0 0.073 13.6 0.0 2.4 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII61222.1 - 0.011 16.0 0.0 0.045 14.1 0.0 2.0 2 1 0 2 2 2 0 Retroviral aspartyl protease DUF1374 PF07118.11 KII61223.1 - 0.056 14.0 2.7 0.058 13.9 2.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1374) DDE_3 PF13358.6 KII61229.1 - 8.8e-34 116.4 0.0 1.1e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII61229.1 - 0.00054 20.1 0.0 0.0008 19.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_ISAZ013 PF07592.11 KII61229.1 - 0.0064 15.5 0.1 0.0086 15.1 0.1 1.2 1 0 0 1 1 1 1 Rhodopirellula transposase DDE domain DDE_3 PF13358.6 KII61230.1 - 5.2e-06 26.3 0.0 6.8e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Kunitz_BPTI PF00014.23 KII61232.1 - 0.00046 20.4 5.2 0.00046 20.4 5.2 2.4 2 1 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF3826 PF12875.7 KII61232.1 - 0.22 11.7 0.0 0.3 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) Furin-like PF00757.20 KII61232.1 - 0.54 10.1 7.6 0.083 12.8 4.1 1.4 2 0 0 2 2 2 0 Furin-like cysteine rich region NSP10 PF09401.10 KII61233.1 - 0.0062 16.6 0.0 2.2 8.3 0.0 2.1 2 0 0 2 2 2 2 RNA synthesis protein NSP10 EbsA PF17255.2 KII61233.1 - 0.054 13.8 0.0 1.9 8.8 0.0 2.1 2 0 0 2 2 2 0 EbsA-like protein RT_RNaseH_2 PF17919.1 KII61235.1 - 0.011 15.7 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Glyco_transf_8C PF08437.10 KII61235.1 - 0.029 14.5 0.1 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 8 C-terminal DUF3826 PF12875.7 KII61237.1 - 0.17 12.0 0.0 0.25 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) DUF2706 PF10913.8 KII61238.1 - 0.066 13.1 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) Kunitz_BPTI PF00014.23 KII61239.1 - 4 7.7 18.5 2 8.7 1.8 2.4 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain PurA PF04845.13 KII61240.1 - 0.0088 15.4 0.1 2.2 7.6 0.0 3.3 1 1 0 2 2 2 2 PurA ssDNA and RNA-binding protein Ydr279_N PF17745.1 KII61241.1 - 0.095 13.0 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Ydr279p protein triple barrel domain DUF4138 PF13595.6 KII61241.1 - 0.15 11.3 0.1 0.17 11.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) zf-C2H2_jaz PF12171.8 KII61242.1 - 0.63 10.4 5.7 0.83 10.0 1.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_jaz PF12171.8 KII61243.1 - 0.1 12.9 0.8 0.1 12.9 0.8 2.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Usp PF00582.26 KII61246.1 - 0.065 13.7 0.0 0.084 13.4 0.0 1.1 1 0 0 1 1 1 0 Universal stress protein family Serpin PF00079.20 KII61247.1 - 1.7e-16 60.5 0.3 2e-16 60.3 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII61248.1 - 3.7e-26 92.3 3.3 4.1e-26 92.2 3.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII61250.1 - 4.2e-14 52.6 3.2 4.8e-14 52.4 3.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AP3B1_C PF14796.6 KII61250.1 - 0.033 14.5 0.1 0.05 13.9 0.1 1.4 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Serpin PF00079.20 KII61251.1 - 1.9e-22 80.1 5.2 2.3e-22 79.9 5.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PBECR2 PF18810.1 KII61251.1 - 0.052 13.8 0.0 0.09 13.1 0.0 1.4 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 Serpin PF00079.20 KII61252.1 - 6.3e-05 22.4 0.2 6.8e-05 22.3 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_1 PF03184.19 KII61253.1 - 1.7e-31 109.2 0.0 2.5e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Aldedh PF00171.22 KII61254.1 - 8.7e-31 106.9 0.9 1.4e-30 106.2 0.9 1.3 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 KII61255.1 - 4.2e-29 101.4 0.0 4.6e-29 101.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 KII61256.1 - 2.2e-104 349.5 0.0 1.7e-52 178.5 0.1 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Aldedh PF00171.22 KII61257.1 - 3.3e-26 91.8 0.0 3.7e-26 91.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Serpin PF00079.20 KII61258.1 - 3.3e-24 85.9 0.1 4e-24 85.6 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Baculo_VP1054 PF05789.11 KII61258.1 - 0.015 14.5 0.6 0.021 14.1 0.6 1.4 1 1 0 1 1 1 0 Baculovirus VP1054 protein Serpin PF00079.20 KII61260.1 - 4.3e-44 151.3 4.8 5.2e-44 151.1 4.8 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII61261.1 - 9.2e-46 156.8 4.9 1.1e-45 156.6 4.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII61262.1 - 1.2e-12 47.9 0.2 1.3e-12 47.7 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.6 KII61263.1 - 7.9e-06 25.5 0.3 9.5e-06 25.2 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Coronavirus_5 PF05528.11 KII61264.1 - 0.13 12.2 1.9 1.4 8.9 0.1 2.4 1 1 1 2 2 2 0 Coronavirus gene 5 protein BRCT PF00533.26 KII61266.1 - 1.4e-06 28.5 2.2 1.2e-05 25.5 0.8 2.7 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KII61266.1 - 0.00016 21.6 0.1 0.00064 19.6 0.0 2.1 2 0 0 2 2 2 1 twin BRCT domain Peptidase_C1 PF00112.23 KII61270.1 - 1.9e-59 201.4 0.4 2.5e-59 201.0 0.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KII61270.1 - 0.00065 18.6 1.3 0.22 10.2 0.0 2.8 3 1 1 4 4 4 2 Peptidase C1-like family GNT-I PF03071.15 KII61272.1 - 4.3e-79 266.3 3.2 5.3e-79 266.0 3.2 1.1 1 0 0 1 1 1 1 GNT-I family Mob1_phocein PF03637.17 KII61273.1 - 0.014 15.4 0.2 0.019 15.0 0.2 1.2 1 0 0 1 1 1 0 Mob1/phocein family TCR PF03638.15 KII61274.1 - 8.7e-12 45.1 35.5 1.3e-10 41.4 20.4 2.4 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 KII61274.1 - 0.32 11.1 25.3 0.2 11.8 16.5 2.5 2 0 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 SLC3A2_N PF16028.5 KII61275.1 - 0.88 9.2 0.0 0.88 9.2 0.0 2.4 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus RT_RNaseH_2 PF17919.1 KII61282.1 - 0.00065 19.7 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DDE_Tnp_IS1595 PF12762.7 KII61283.1 - 5e-08 33.1 0.0 8.7e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Annexin_like PF18411.1 KII61283.1 - 0.034 14.4 0.3 0.94 9.8 0.1 2.3 1 1 1 2 2 2 0 Annexin-like domain XTBD PF11952.8 KII61283.1 - 0.084 12.6 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD LEDGF PF11467.8 KII61285.1 - 0.019 14.6 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) RVT_1 PF00078.27 KII61288.1 - 2.2e-10 40.4 0.1 1.3e-07 31.4 0.0 3.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) KH_10 PF17905.1 KII61291.1 - 0.12 12.8 1.0 0.14 12.6 0.5 1.4 2 0 0 2 2 2 0 GLD-3 KH domain 5 RED_C PF07807.11 KII61293.1 - 0.09 13.3 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 RED-like protein C-terminal region ClpS PF02617.17 KII61294.1 - 0.017 14.9 0.1 0.026 14.3 0.1 1.3 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS rve PF00665.26 KII61295.1 - 1.4e-14 54.3 0.0 1.9e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII61295.1 - 7.4e-05 22.4 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain AbiJ_NTD4 PF18863.1 KII61295.1 - 0.071 13.6 0.0 0.079 13.4 0.0 1.1 1 0 0 1 1 1 0 AbiJ N-terminal domain 4 rve PF00665.26 KII61298.1 - 6.4e-14 52.2 0.0 6.4e-13 48.9 0.0 2.0 1 1 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61298.1 - 0.061 13.4 0.5 0.2 11.8 0.3 2.0 2 0 0 2 2 2 0 Integrase zinc binding domain HobA PF12163.8 KII61301.1 - 0.017 14.7 0.2 0.8 9.2 0.0 2.1 1 1 1 2 2 2 0 DNA replication regulator DDE_3 PF13358.6 KII61303.1 - 2.9e-07 30.3 0.0 3.5e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH_2 PF17919.1 KII61304.1 - 1.2e-17 63.8 0.0 1.8e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61304.1 - 3.2e-13 49.9 0.0 9.5e-13 48.3 0.0 1.7 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII61305.1 - 0.013 15.0 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) GATA PF00320.27 KII61306.1 - 3.1e-15 55.5 10.8 2.1e-14 52.8 7.6 2.6 2 0 0 2 2 2 1 GATA zinc finger zf-TFIIB PF13453.6 KII61306.1 - 1.7e-05 24.0 0.1 1.7e-05 24.0 0.1 2.3 2 0 0 2 2 2 1 Transcription factor zinc-finger TF_Zn_Ribbon PF08271.12 KII61306.1 - 0.00011 21.6 9.1 0.0049 16.4 1.9 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding eIF-5_eIF-2B PF01873.17 KII61306.1 - 0.00045 20.1 5.5 0.11 12.4 0.2 2.8 2 0 0 2 2 2 2 Domain found in IF2B/IF5 DUF2387 PF09526.10 KII61306.1 - 0.0065 16.6 7.0 0.56 10.4 0.4 3.2 1 1 2 3 3 3 2 Probable metal-binding protein (DUF2387) Vps36-NZF-N PF16988.5 KII61306.1 - 0.023 14.1 5.9 0.064 12.7 0.6 2.5 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain ArfGap PF01412.18 KII61306.1 - 0.028 14.5 5.4 0.03 14.4 0.5 2.5 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Zn-ribbon_8 PF09723.10 KII61306.1 - 0.057 13.6 6.0 0.37 10.9 0.1 3.0 2 1 2 4 4 4 0 Zinc ribbon domain zf-piccolo PF05715.13 KII61306.1 - 0.5 10.5 10.0 0.73 10.0 0.5 3.4 2 1 1 3 3 3 0 Piccolo Zn-finger zinc_ribbon_15 PF17032.5 KII61306.1 - 1.2 9.9 11.5 36 5.2 11.0 2.9 1 1 2 3 3 3 0 zinc-ribbon family NOB1_Zn_bind PF08772.11 KII61306.1 - 1.5 9.1 12.4 0.79 9.9 1.4 2.5 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like OrfB_Zn_ribbon PF07282.11 KII61306.1 - 1.6 8.7 8.4 10 6.1 2.0 2.7 1 1 0 2 2 2 0 Putative transposase DNA-binding domain DZR PF12773.7 KII61306.1 - 1.8 8.6 11.7 2.4e+02 1.8 11.9 2.7 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_10 PF10058.9 KII61306.1 - 2.5 7.9 10.9 5.6 6.8 2.8 2.9 2 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein FYVE PF01363.21 KII61306.1 - 2.9 8.1 8.3 13 6.0 8.3 2.1 1 1 0 1 1 1 0 FYVE zinc finger RPA_interact_C PF14768.6 KII61306.1 - 3.6 8.2 6.5 21 5.7 5.9 2.3 1 1 1 2 2 2 0 Replication protein A interacting C-terminal A2L_zn_ribbon PF08792.10 KII61306.1 - 4.6 7.1 11.4 6.5 6.6 3.1 3.6 3 1 1 4 4 4 0 A2L zinc ribbon domain Peptidase_Mx PF15887.5 KII61307.1 - 0.0069 15.8 0.0 0.0079 15.6 0.0 1.1 1 0 0 1 1 1 1 Putative zinc-binding metallo-peptidase Porin_3 PF01459.22 KII61309.1 - 1.7e-08 34.3 0.0 2.6e-08 33.6 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic porin ATG11 PF10377.9 KII61310.1 - 1.7e-05 24.9 0.1 2e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Autophagy-related protein 11 DUF3737 PF12541.8 KII61310.1 - 0.023 13.9 0.1 0.036 13.3 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3737) Erf4 PF10256.9 KII61311.1 - 3.1e-24 85.3 1.1 3.5e-24 85.1 1.1 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Rib_5-P_isom_A PF06026.14 KII61312.1 - 1.2e-52 178.0 0.1 1.5e-52 177.6 0.1 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Tetraspanin PF00335.20 KII61313.1 - 0.0017 18.1 1.3 0.0051 16.6 1.3 1.7 1 1 0 1 1 1 1 Tetraspanin family Phtf-FEM1B_bdg PF12129.8 KII61313.1 - 0.024 14.5 0.3 0.035 14.0 0.0 1.5 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor UPF0020 PF01170.18 KII61314.1 - 1.2e-11 44.7 0.0 1.4e-10 41.2 0.0 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 KII61314.1 - 0.00084 19.1 0.0 0.068 12.9 0.0 2.2 2 0 0 2 2 2 1 DNA methylase N6_Mtase PF02384.16 KII61314.1 - 0.039 13.2 0.0 0.16 11.2 0.0 1.8 1 1 0 1 1 1 0 N-6 DNA Methylase Methyltransf_15 PF09445.10 KII61314.1 - 0.078 12.5 0.1 0.42 10.2 0.1 1.9 1 1 0 1 1 1 0 RNA cap guanine-N2 methyltransferase MethyltransfD12 PF02086.15 KII61314.1 - 0.099 12.3 0.3 1.6 8.3 0.0 2.0 1 1 1 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.15 KII61314.1 - 0.16 11.6 0.1 1.6 8.3 0.1 2.1 1 1 0 1 1 1 0 Conserved hypothetical protein 95 WD40 PF00400.32 KII61315.1 - 3.6e-15 56.1 19.7 0.00033 21.4 0.2 6.9 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII61315.1 - 0.0031 17.8 0.5 2.1 8.7 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KII61315.1 - 0.0033 16.8 0.1 0.23 10.7 0.0 2.3 1 1 0 2 2 2 1 WD40-like domain FH2 PF02181.23 KII61315.1 - 0.0084 15.3 1.3 0.013 14.6 1.3 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain GHD PF17834.1 KII61315.1 - 0.02 14.9 0.5 0.26 11.4 0.1 2.4 2 0 0 2 2 2 0 Beta-sandwich domain in beta galactosidase YabA PF06156.13 KII61315.1 - 0.023 15.3 0.4 0.052 14.2 0.4 1.6 1 0 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 KII61315.1 - 0.11 12.3 0.1 0.26 11.1 0.1 1.6 1 0 0 1 1 1 0 Septum formation initiator DUF1465 PF07323.12 KII61315.1 - 0.12 12.3 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) HALZ PF02183.18 KII61315.1 - 0.38 11.0 1.2 0.71 10.1 1.2 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Lipocalin PF00061.23 KII61316.1 - 0.0046 17.2 0.5 0.0062 16.7 0.5 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family GAS2 PF02187.17 KII61318.1 - 0.0032 17.5 0.0 0.01 15.9 0.0 1.8 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 KII61319.1 - 1.1e-11 44.8 0.1 2.6e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain DIL PF01843.19 KII61319.1 - 0.13 12.5 1.3 0.3 11.4 0.1 2.1 2 1 1 3 3 3 0 DIL domain DDE_Tnp_IS1595 PF12762.7 KII61320.1 - 9.1e-06 25.8 0.0 4e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain Nipped-B_C PF12830.7 KII61320.1 - 0.057 13.3 0.0 0.37 10.7 0.0 1.9 1 1 1 2 2 2 0 Sister chromatid cohesion C-terminus NUFIP1 PF10453.9 KII61321.1 - 9.8e-06 25.3 7.4 9.8e-06 25.3 7.4 2.0 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) IlvC PF01450.19 KII61321.1 - 0.13 12.6 1.7 0.22 11.8 1.7 1.5 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain MCM_bind PF09739.9 KII61321.1 - 1.1 7.6 10.4 1.5 7.2 10.4 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Peptidase_M3 PF01432.20 KII61322.1 - 6.4e-128 427.9 1.5 8.4e-128 427.5 1.5 1.1 1 0 0 1 1 1 1 Peptidase family M3 PP2C PF00481.21 KII61323.1 - 2e-07 30.9 0.0 0.0013 18.4 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 KII61323.1 - 0.042 13.5 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein phosphatase 2C Sortilin-Vps10 PF15902.5 KII61326.1 - 0.03 13.1 0.0 0.15 10.8 0.0 1.8 2 0 0 2 2 2 0 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII61327.1 - 1.7e-07 31.3 10.1 1.7e-07 31.3 10.1 3.1 3 1 0 3 3 3 2 Low-density lipoprotein receptor domain class A tRNA-synt_1g PF09334.11 KII61328.1 - 1.5e-33 116.1 0.4 2.2e-33 115.6 0.4 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KII61328.1 - 0.002 18.1 0.0 0.0031 17.5 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA TraC_F_IV PF11130.8 KII61328.1 - 0.092 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer tRNA-synt_1g PF09334.11 KII61329.1 - 2.1e-70 237.5 1.9 2.4e-70 237.2 1.9 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KII61329.1 - 8.6e-06 24.3 0.0 1.2e-05 23.8 0.0 1.3 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) C1_1 PF00130.22 KII61329.1 - 1.7 8.6 15.0 1.3 9.0 0.8 2.9 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HypA PF01155.19 KII61329.1 - 8 6.5 7.8 3.7e+02 1.2 7.8 2.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA HTH_Tnp_Tc5 PF03221.16 KII61330.1 - 6.2e-05 22.9 2.1 0.0027 17.7 2.1 2.4 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain Glyco_transf_41 PF13844.6 KII61331.1 - 9.2e-158 525.5 0.3 1.2e-85 287.8 0.3 2.2 1 1 1 2 2 2 2 Glycosyl transferase family 41 TPR_1 PF00515.28 KII61331.1 - 1.9e-51 169.8 31.0 3.8e-07 29.6 0.2 13.7 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_11 PF13414.6 KII61331.1 - 1.8e-49 165.1 20.2 1e-08 34.7 0.1 12.0 5 2 7 12 12 12 8 TPR repeat TPR_2 PF07719.17 KII61331.1 - 1.3e-44 146.7 26.7 1e-05 25.2 0.0 13.4 14 0 0 14 14 13 10 Tetratricopeptide repeat TPR_8 PF13181.6 KII61331.1 - 2.3e-40 133.4 19.3 4.9e-05 23.2 0.0 12.9 14 0 0 14 14 12 9 Tetratricopeptide repeat TPR_17 PF13431.6 KII61331.1 - 1.1e-30 103.8 23.0 2.1e-05 24.6 0.1 11.9 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_19 PF14559.6 KII61331.1 - 1.1e-28 99.5 2.9 8e-06 26.3 0.0 7.5 2 1 7 10 10 10 8 Tetratricopeptide repeat TPR_14 PF13428.6 KII61331.1 - 4.1e-28 95.7 0.0 0.00012 22.6 0.0 9.9 5 4 6 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 KII61331.1 - 7.9e-26 90.4 0.0 1.8e-06 28.5 0.0 7.0 4 1 3 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 KII61331.1 - 3e-23 81.9 19.0 1.4e-05 25.2 0.3 8.5 4 2 5 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 KII61331.1 - 3.8e-18 64.7 12.2 2e-06 27.4 0.2 9.2 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.6 KII61331.1 - 4.3e-15 54.6 18.4 0.099 12.7 0.0 11.5 14 0 0 14 14 13 4 Tetratricopeptide repeat TPR_6 PF13174.6 KII61331.1 - 1.2e-12 47.6 0.0 0.37 11.5 0.0 7.8 8 0 0 8 8 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KII61331.1 - 1.3e-09 38.1 18.0 0.027 14.7 0.0 6.4 3 2 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 KII61331.1 - 4.5e-08 33.1 2.0 4 7.7 0.0 5.9 5 1 1 6 6 6 2 Tetratricopeptide repeat NARP1 PF12569.8 KII61331.1 - 4.8e-08 32.4 3.0 0.12 11.2 0.0 5.2 2 1 3 6 6 6 2 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 KII61331.1 - 1.2e-05 24.7 0.6 1.7 7.8 0.4 4.8 2 1 2 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KII61331.1 - 0.00077 18.9 0.5 1.1 8.6 0.1 3.5 1 1 3 4 4 4 1 MalT-like TPR region ChAPs PF09295.10 KII61331.1 - 0.002 17.2 0.1 0.33 9.9 0.0 2.6 1 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.17 KII61331.1 - 0.028 14.9 0.7 28 5.1 0.0 3.6 2 1 2 4 4 4 0 Bacterial transcriptional activator domain TPR_3 PF07720.12 KII61331.1 - 0.066 13.2 5.6 3.2 7.8 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat SNAP PF14938.6 KII61331.1 - 0.27 10.6 7.3 3.2 7.1 0.1 3.8 1 1 2 3 3 3 0 Soluble NSF attachment protein, SNAP PPR PF01535.20 KII61331.1 - 0.66 10.4 5.2 19 5.8 0.0 4.6 5 0 0 5 5 4 0 PPR repeat Mad3_BUB1_I PF08311.12 KII61331.1 - 1.4 8.9 5.8 77 3.3 0.2 4.9 5 1 1 6 6 6 0 Mad3/BUB1 homology region 1 Ribosomal_S2 PF00318.20 KII61332.1 - 6.8e-31 107.2 0.2 1.6e-14 53.7 0.1 2.2 2 0 0 2 2 2 2 Ribosomal protein S2 PhoLip_ATPase_C PF16212.5 KII61335.1 - 1.1e-47 162.9 28.4 1.1e-47 162.9 28.4 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 KII61335.1 - 1.7e-11 44.1 0.1 8.4e-11 41.8 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KII61335.1 - 3.4e-07 30.8 0.0 0.00019 21.8 0.0 3.1 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Tra_M PF05261.11 KII61335.1 - 0.47 10.4 4.5 4.7 7.2 0.2 3.3 2 1 1 3 3 3 0 TraM protein, DNA-binding PhoLip_ATPase_C PF16212.5 KII61336.1 - 3.6e-49 167.8 23.1 3.6e-49 167.8 23.1 2.4 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 KII61336.1 - 4.2e-11 42.8 0.1 1.3e-09 38.0 0.0 2.6 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KII61336.1 - 1.3e-10 42.0 0.2 4.9e-06 27.0 0.1 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KII61336.1 - 0.0097 15.7 0.4 0.045 13.5 0.1 2.0 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1126 PF06565.12 KII61336.1 - 0.061 13.1 0.0 0.23 11.3 0.0 1.9 1 0 0 1 1 1 0 DUF1126 PH-like domain SAM_3 PF18016.1 KII61337.1 - 0.013 15.2 0.6 0.027 14.3 0.6 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) CP2 PF04516.15 KII61339.1 - 3.7e-11 42.8 0.4 4.8e-11 42.4 0.4 1.2 1 0 0 1 1 1 1 CP2 transcription factor Imm39 PF15568.6 KII61339.1 - 0.13 12.4 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 39 Peptidase_M28 PF04389.17 KII61344.1 - 0.059 13.1 0.0 0.065 12.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M28 ubiquitin PF00240.23 KII61345.1 - 7.8e-07 28.8 0.0 1.4e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KII61345.1 - 0.0031 17.3 0.0 0.088 12.7 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like RNA_pol_Rpb2_6 PF00562.28 KII61348.1 - 4.2e-28 98.5 0.0 4.9e-28 98.3 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 KII61348.1 - 1.3e-07 31.9 1.3 3.4e-07 30.6 0.5 2.0 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 KII61349.1 - 1.5e-20 73.1 0.0 2.3e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 KII61349.1 - 0.00011 21.9 1.1 0.00018 21.2 0.1 1.9 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_1 PF04563.15 KII61349.1 - 0.0076 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_1 PF04563.15 KII61350.1 - 4.6e-29 101.4 0.5 5.2e-29 101.2 0.5 1.0 1 0 0 1 1 1 1 RNA polymerase beta subunit DDE_3 PF13358.6 KII61351.1 - 3.2e-11 43.2 0.0 3.5e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease CRIC_ras_sig PF10534.9 KII61351.1 - 0.0092 16.1 0.2 0.02 15.1 0.1 1.6 2 0 0 2 2 2 1 Connector enhancer of kinase suppressor of ras DUF4371 PF14291.6 KII61354.1 - 0.0071 16.0 0.1 0.0081 15.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Globin PF00042.22 KII61355.1 - 2.1e-09 37.9 0.0 2.9e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Globin EMP24_GP25L PF01105.24 KII61355.1 - 0.077 12.9 0.7 0.12 12.4 0.7 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF677 PF05055.12 KII61355.1 - 0.095 11.6 0.6 0.13 11.1 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) PAP_central PF04928.17 KII61356.1 - 5.6e-78 261.4 0.1 7.3e-78 261.0 0.1 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 KII61356.1 - 4.9e-16 58.8 1.6 2.5e-13 50.0 0.5 2.4 1 1 1 2 2 2 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 KII61356.1 - 2.2e-06 27.9 0.0 6.6e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain RNA_pol_Rpc34 PF05158.12 KII61358.1 - 1.7e-29 103.3 0.1 1.5e-28 100.1 0.1 1.9 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit TrmB PF01978.19 KII61358.1 - 2.6e-06 27.2 0.6 0.12 12.3 0.0 3.7 3 1 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB RPA_C PF08784.11 KII61358.1 - 0.00024 21.7 0.1 0.95 10.2 0.1 2.8 2 0 0 2 2 2 2 Replication protein A C terminal HTH_24 PF13412.6 KII61358.1 - 0.0073 15.8 2.6 0.051 13.1 0.9 3.2 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 KII61358.1 - 0.014 15.8 0.2 1.5 9.2 0.0 3.1 4 0 0 4 4 4 0 Transcriptional regulator MarR PF01047.22 KII61358.1 - 0.063 13.2 0.1 1.1 9.2 0.0 2.5 2 0 0 2 2 2 0 MarR family Tubulin PF00091.25 KII61360.1 - 8.4e-54 182.8 0.0 2.5e-53 181.2 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KII61360.1 - 1.7e-47 160.7 0.0 3e-47 159.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Lipase_3 PF01764.25 KII61360.1 - 9.2e-05 22.3 0.4 0.00044 20.1 0.0 2.2 3 0 0 3 3 3 1 Lipase (class 3) Tubulin_2 PF13809.6 KII61360.1 - 0.0074 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin like T2SSE PF00437.20 KII61360.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF4371 PF14291.6 KII61363.1 - 0.07 12.8 1.5 0.1 12.2 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4371) zf-C2H2 PF00096.26 KII61364.1 - 0.0054 17.1 0.2 0.0054 17.1 0.2 3.5 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII61364.1 - 0.052 14.4 0.4 0.052 14.4 0.4 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KII61364.1 - 0.13 12.7 4.5 4.7 7.8 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf_UBZ PF18439.1 KII61364.1 - 0.24 11.0 1.9 2.4 7.8 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 KII61364.1 - 0.43 10.4 0.0 0.43 10.4 0.0 2.6 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-Di19 PF05605.12 KII61364.1 - 1.2 9.4 5.3 0.8 10.0 3.0 1.8 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 KII61364.1 - 2.5 7.8 4.6 4.2 7.1 1.5 2.3 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF2417 PF10329.9 KII61365.1 - 0.026 13.9 0.1 0.03 13.8 0.1 1.2 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Baculo_11_kDa PF06143.11 KII61365.1 - 0.51 10.0 6.1 0.28 10.8 3.7 1.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family DNA_pol_A_exo1 PF01612.20 KII61366.1 - 0.0022 17.8 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease ABC_tran PF00005.27 KII61368.1 - 4.8e-11 43.3 0.2 7.4e-11 42.7 0.2 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KII61368.1 - 0.0029 17.5 1.0 0.064 13.1 0.2 2.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 KII61368.1 - 0.011 15.8 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_7 PF12775.7 KII61368.1 - 0.017 14.6 0.1 0.027 14.0 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 KII61368.1 - 0.019 15.2 0.2 0.29 11.4 0.2 2.0 1 1 1 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 KII61368.1 - 0.033 13.5 0.1 0.046 13.1 0.1 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PRK PF00485.18 KII61368.1 - 0.07 12.9 0.4 0.21 11.3 0.1 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DEAD PF00270.29 KII61368.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase TsaE PF02367.17 KII61368.1 - 0.15 12.0 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 KII61368.1 - 0.24 10.4 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 KII61369.1 - 3.7e-08 34.0 0.0 4.9e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KII61369.1 - 1.7e-07 30.9 0.1 1.9e-07 30.8 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain ArfGap PF01412.18 KII61370.1 - 5.8e-14 52.2 2.4 8.4e-14 51.7 0.5 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ank_4 PF13637.6 KII61370.1 - 0.003 18.1 0.1 0.015 15.9 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII61370.1 - 0.0062 16.9 0.3 3.8 8.4 0.1 3.0 2 0 0 2 2 2 1 Ankyrin repeat GIT_SHD PF08518.11 KII61370.1 - 0.013 15.2 0.8 0.034 13.8 0.2 2.1 2 0 0 2 2 2 0 Spa2 homology domain (SHD) of GIT Ank_2 PF12796.7 KII61370.1 - 0.032 14.8 0.5 0.12 13.0 0.2 2.1 2 1 0 2 2 2 0 Ankyrin repeats (3 copies) Polbeta PF18765.1 KII61370.1 - 0.036 14.1 0.2 0.12 12.5 0.0 2.0 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase Helicase_C PF00271.31 KII61371.1 - 1e-05 25.8 0.0 2.1e-05 24.8 0.0 1.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 KII61371.1 - 0.0096 15.1 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Pyr_redox_2 PF07992.14 KII61372.1 - 2.6e-11 43.3 0.0 3.8e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AIF_C PF14721.6 KII61372.1 - 1.8e-08 34.8 0.0 4.9e-05 23.7 0.1 2.6 1 1 1 2 2 2 2 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox PF00070.27 KII61372.1 - 0.013 16.0 0.0 0.74 10.4 0.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HlyD_2 PF12700.7 KII61374.1 - 0.075 11.8 0.6 1 8.0 0.1 2.0 1 1 1 2 2 2 0 HlyD family secretion protein TrmB PF01978.19 KII61374.1 - 0.078 12.9 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB RA PF00788.23 KII61375.1 - 5e-10 39.9 0.3 1.1e-09 38.8 0.0 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain C1_1 PF00130.22 KII61375.1 - 4.1e-08 33.0 4.6 1e-07 31.7 4.6 1.7 1 1 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) TUG-UBL1 PF11470.8 KII61375.1 - 0.023 14.9 0.5 0.071 13.4 0.5 1.9 1 1 0 1 1 1 0 TUG ubiquitin-like domain Ras_bdg_2 PF14847.6 KII61375.1 - 0.039 14.3 0.2 0.089 13.1 0.2 1.6 1 0 0 1 1 1 0 Ras-binding domain of Byr2 Ion_trans PF00520.31 KII61376.1 - 6.1e-49 166.5 91.6 1e-24 87.1 27.9 3.1 3 0 0 3 3 3 3 Ion transport protein EGF_2 PF07974.13 KII61380.1 - 0.039 14.3 23.4 0.087 13.2 0.8 3.4 3 1 0 3 3 3 0 EGF-like domain hEGF PF12661.7 KII61380.1 - 2.4 8.9 0.1 2.4 8.9 0.1 4.0 4 1 0 4 4 4 0 Human growth factor-like EGF EGF PF00008.27 KII61381.1 - 0.0002 21.6 4.9 0.0002 21.6 4.9 3.6 3 1 0 3 3 3 1 EGF-like domain Helicase_C PF00271.31 KII61382.1 - 7.1e-11 42.4 0.0 1.6e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 KII61382.1 - 6.2e-05 23.6 4.6 0.00018 22.2 4.6 1.9 1 0 0 1 1 1 1 RecQ zinc-binding zf-P11 PF03854.14 KII61382.1 - 0.024 14.3 1.2 0.051 13.2 1.2 1.5 1 0 0 1 1 1 0 P-11 zinc finger VATC PF18716.1 KII61382.1 - 0.11 12.4 2.5 0.26 11.2 2.5 1.6 1 0 0 1 1 1 0 Vms1-associating treble clef domain DEAD PF00270.29 KII61383.1 - 0.0059 16.4 0.0 0.0064 16.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase PGI PF00342.19 KII61386.1 - 1.7e-56 191.8 0.1 2.1e-56 191.5 0.1 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase LGFP PF08310.11 KII61386.1 - 0.076 13.6 0.2 0.13 12.9 0.2 1.3 1 0 0 1 1 1 0 LGFP repeat Ribosomal_L26 PF16906.5 KII61387.1 - 4.9e-38 129.5 4.1 6.4e-38 129.1 4.1 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal V-SNARE_C PF12352.8 KII61388.1 - 9.8e-10 38.6 2.4 5.9e-07 29.7 1.1 3.0 3 1 0 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus SF-assemblin PF06705.11 KII61388.1 - 0.0051 16.2 5.2 0.0052 16.2 3.5 1.7 1 1 1 2 2 2 1 SF-assemblin/beta giardin Spore_III_AB PF09548.10 KII61388.1 - 0.0096 16.0 3.5 0.2 11.8 1.6 2.4 1 1 1 2 2 2 2 Stage III sporulation protein AB (spore_III_AB) DDE_3 PF13358.6 KII61390.1 - 2.1e-12 47.0 0.0 2.7e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease EZH2_WD-Binding PF11616.8 KII61391.1 - 0.014 15.5 0.5 0.025 14.7 0.5 1.5 1 0 0 1 1 1 0 WD repeat binding protein EZH2 Antimicrobial19 PF08225.11 KII61391.1 - 5 6.8 5.5 0.76 9.5 0.4 2.3 2 0 0 2 2 2 0 Pseudin antimicrobial peptide RP854 PF17460.2 KII61392.1 - 0.025 14.3 0.7 0.025 14.3 0.7 1.8 2 0 0 2 2 2 0 Uncharacterized protein RP854 Sugar_tr PF00083.24 KII61393.1 - 2.7e-49 168.3 32.3 3.2e-49 168.0 32.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII61393.1 - 6e-07 28.7 34.0 6e-07 28.7 34.0 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Holin_BlyA PF05102.12 KII61394.1 - 0.066 13.2 0.5 0.066 13.2 0.5 1.9 2 0 0 2 2 2 0 holin, BlyA family Fer4 PF00037.27 KII61395.1 - 5.5e-14 51.3 17.5 1.9e-08 33.8 4.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 KII61395.1 - 5.7e-13 49.2 10.5 9.8e-13 48.5 10.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 KII61395.1 - 2.9e-10 40.9 5.8 0.00014 22.7 0.1 2.5 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 KII61395.1 - 4.2e-09 36.4 31.6 1.1e-05 25.5 12.5 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 KII61395.1 - 1.1e-08 35.0 21.0 2.3e-06 27.6 12.4 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 KII61395.1 - 2.7e-08 33.8 10.6 4.7e-08 33.1 10.6 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 KII61395.1 - 2.5e-07 31.0 17.1 0.00026 21.4 11.2 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 KII61395.1 - 3.9e-07 29.9 17.8 0.00042 20.3 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 KII61395.1 - 1.4e-06 28.0 12.3 0.0029 17.6 2.0 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 KII61395.1 - 7.3e-06 26.1 11.1 0.00031 21.0 1.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 KII61395.1 - 0.0003 21.3 11.2 0.048 14.2 12.4 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 KII61395.1 - 0.0011 19.5 11.1 0.16 12.6 0.8 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 KII61395.1 - 0.024 14.8 8.2 0.88 9.8 1.4 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 KII61395.1 - 0.029 14.6 5.8 0.92 9.8 0.3 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_3 PF12798.7 KII61395.1 - 0.2 12.7 16.3 0.37 11.8 4.1 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 KII61395.1 - 0.28 11.4 6.2 1.4 9.1 0.8 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 KII61395.1 - 0.55 11.1 11.9 2.6 9.0 1.8 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain RCC1_2 PF13540.6 KII61396.1 - 6.5e-24 83.2 10.2 1.5e-08 34.2 0.2 3.7 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 KII61396.1 - 9.5e-16 58.2 6.7 4.9e-07 30.3 0.0 4.5 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 KII61396.1 - 6.2 6.9 5.6 3.4 7.8 0.1 3.3 4 0 0 4 4 4 0 Kelch motif DEAD PF00270.29 KII61397.1 - 5.8e-25 88.1 0.0 1.8e-15 57.1 0.0 2.3 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KII61397.1 - 2.4e-06 27.8 0.0 1.1e-05 25.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain EGF PF00008.27 KII61398.1 - 0.00012 22.3 43.0 0.00013 22.2 2.7 5.9 3 2 1 4 4 4 3 EGF-like domain EGF_2 PF07974.13 KII61398.1 - 0.011 16.0 49.4 0.024 15.0 0.6 5.1 5 1 1 6 6 6 0 EGF-like domain GTP_EFTU PF00009.27 KII61399.1 - 1.1e-20 74.0 0.0 2e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KII61399.1 - 2.7e-13 49.9 0.0 7.3e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 PduV-EutP PF10662.9 KII61399.1 - 0.0088 15.8 0.1 0.022 14.5 0.1 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 KII61399.1 - 0.015 15.3 0.1 0.06 13.4 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase PQQ PF01011.21 KII61400.1 - 4.6e-21 73.7 0.3 0.002 18.0 0.0 5.9 6 0 0 6 6 6 4 PQQ enzyme repeat PQQ_3 PF13570.6 KII61400.1 - 2.4e-19 69.2 0.0 1.7e-06 28.4 0.0 8.2 8 0 0 8 8 8 3 PQQ-like domain AMP-binding PF00501.28 KII61400.1 - 1.7e-18 66.5 0.0 3.1e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme PQQ_2 PF13360.6 KII61400.1 - 5e-14 52.5 0.0 3.9e-06 26.6 0.0 3.1 1 1 1 2 2 2 2 PQQ-like domain PP-binding PF00550.25 KII61400.1 - 0.0041 17.4 0.1 0.013 15.8 0.1 1.9 1 1 0 1 1 1 1 Phosphopantetheine attachment site DUF1126 PF06565.12 KII61400.1 - 0.11 12.3 0.0 0.61 9.9 0.0 2.2 1 1 1 2 2 2 0 DUF1126 PH-like domain CSN8_PSD8_EIF3K PF10075.9 KII61401.1 - 7e-17 61.7 0.5 1.1e-16 61.1 0.5 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family DNA_mis_repair PF01119.19 KII61401.1 - 0.084 12.5 0.0 1.8 8.2 0.0 2.1 2 0 0 2 2 2 0 DNA mismatch repair protein, C-terminal domain PBP1_TM PF14812.6 KII61403.1 - 0.031 14.6 3.9 0.031 14.6 3.9 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tim54 PF11711.8 KII61403.1 - 6.6 5.4 13.0 13 4.4 13.0 1.7 1 1 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDE_3 PF13358.6 KII61405.1 - 7.1e-05 22.6 0.0 9.6e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Transglut_core PF01841.19 KII61406.1 - 0.012 16.0 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily Peptidase_M17 PF00883.21 KII61408.1 - 3.5e-116 387.8 0.2 4.2e-116 387.6 0.2 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 KII61408.1 - 6e-11 42.3 0.0 1.5e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain DUF4371 PF14291.6 KII61409.1 - 0.043 13.5 0.2 0.06 13.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) MULE PF10551.9 KII61414.1 - 4.2e-11 43.1 0.1 6.4e-11 42.5 0.1 1.3 1 0 0 1 1 1 1 MULE transposase domain SBDS PF01172.18 KII61416.1 - 9.6e-27 92.9 1.4 2.5e-26 91.6 1.4 1.7 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 KII61416.1 - 4.1e-16 59.0 1.8 8.5e-16 58.0 1.8 1.5 1 0 0 1 1 1 1 SBDS protein C-terminal domain NopRA1 PF16201.5 KII61416.1 - 0.066 12.8 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Nucleolar pre-ribosomal-associated protein 1 Homeodomain PF00046.29 KII61417.1 - 0.008 16.0 0.0 0.023 14.6 0.0 1.7 2 0 0 2 2 2 1 Homeodomain PRP21_like_P PF12230.8 KII61419.1 - 1.7e-37 129.4 14.5 4.4e-37 128.1 14.5 1.8 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 KII61419.1 - 4.5e-33 113.0 10.4 2.3e-18 65.9 1.9 3.0 3 0 0 3 3 3 2 Surp module ubiquitin PF00240.23 KII61419.1 - 4.9e-09 35.8 0.1 4.9e-09 35.8 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 KII61419.1 - 0.00013 22.4 0.3 0.00034 21.0 0.3 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain zf-C4H2 PF10146.9 KII61419.1 - 0.007 16.7 6.5 0.007 16.7 6.5 3.0 3 0 0 3 3 3 1 Zinc finger-containing protein PUA PF01472.20 KII61420.1 - 3.4e-15 55.8 0.0 5.3e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 PUA domain Pre-PUA PF17832.1 KII61420.1 - 5.4e-14 52.6 0.6 8.6e-14 52.0 0.6 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain MTH865 PF07747.11 KII61421.1 - 0.032 14.0 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 MTH865-like family Ribosomal_S16 PF00886.19 KII61422.1 - 1.5e-19 69.8 0.0 2.3e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 DUF378 PF04070.12 KII61422.1 - 0.096 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF378) ATP-synt_F PF01990.17 KII61423.1 - 2.2e-26 92.0 0.1 2.7e-26 91.7 0.1 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit Ofd1_CTDD PF10637.9 KII61426.1 - 0.015 14.6 0.1 0.022 14.1 0.1 1.2 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term DUF5104 PF17117.5 KII61426.1 - 0.032 14.6 3.1 0.04 14.4 2.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5104) DRY_EERY PF09750.9 KII61427.1 - 1.6e-12 47.8 11.4 1.5e-10 41.5 0.0 4.2 2 2 2 4 4 4 2 Alternative splicing regulator YchF-GTPase_C PF06071.13 KII61428.1 - 4.4e-32 110.1 2.3 9.6e-32 109.0 2.3 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF933) TGS PF02824.21 KII61428.1 - 0.0048 16.9 0.0 0.0083 16.2 0.0 1.3 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 KII61429.1 - 8.4e-23 80.6 0.0 1e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KII61429.1 - 7.8e-07 28.7 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KII61429.1 - 2.8e-05 24.2 0.0 0.21 11.6 0.0 2.5 1 1 1 2 2 2 2 Dynamin family Roc PF08477.13 KII61429.1 - 0.066 13.4 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RRM_1 PF00076.22 KII61430.1 - 1.8e-14 53.3 0.0 2.3e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L21p PF00829.21 KII61431.1 - 9.4e-22 77.2 1.9 1.4e-21 76.6 1.9 1.3 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein E1-E2_ATPase PF00122.20 KII61432.1 - 4.6e-39 133.8 1.3 2.2e-38 131.6 0.0 2.4 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KII61432.1 - 2.6e-08 34.4 0.0 4.3e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 KII61432.1 - 8.2e-08 32.6 0.9 2.9e-07 30.8 0.9 1.9 1 0 0 1 1 1 1 Heavy-metal-associated domain PDR_CDR PF06422.12 KII61432.1 - 0.6 10.1 2.6 3 7.8 0.2 2.6 2 0 0 2 2 2 0 CDR ABC transporter RhoGAP PF00620.27 KII61433.1 - 2.6e-07 30.6 0.5 6.1e-07 29.4 0.1 1.7 2 1 1 3 3 3 1 RhoGAP domain BAR PF03114.18 KII61433.1 - 8.8e-07 28.8 1.3 1.4e-06 28.2 0.8 1.5 2 0 0 2 2 2 1 BAR domain RhoGAP PF00620.27 KII61434.1 - 5.3e-26 91.3 0.0 7.2e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain Pkinase PF00069.25 KII61435.1 - 2.6e-12 46.7 0.0 3.3e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII61435.1 - 4.3e-07 29.5 0.0 5.6e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_S10 PF00338.22 KII61436.1 - 9e-17 61.1 0.0 1.2e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF2540 PF10802.8 KII61436.1 - 0.0068 16.5 0.2 0.015 15.4 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2540) Peptidase_M50 PF02163.22 KII61437.1 - 0.00016 21.1 8.6 0.01 15.2 2.0 2.1 1 1 1 2 2 2 2 Peptidase family M50 Ribosomal_L36e PF01158.18 KII61438.1 - 1.8e-36 124.2 7.3 2.1e-36 124.1 7.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e GCR1_C PF12550.8 KII61438.1 - 0.0092 16.3 0.3 0.024 15.0 0.1 1.7 1 1 1 2 2 2 1 Transcriptional activator of glycolytic enzymes Peptidase_S9 PF00326.21 KII61439.1 - 7.2e-34 117.1 0.0 8.9e-34 116.8 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KII61439.1 - 4.4e-08 32.7 0.0 0.00037 19.9 0.0 2.5 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KII61439.1 - 6.6e-05 22.7 0.0 0.00011 21.9 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 KII61439.1 - 0.0012 18.5 0.0 0.0015 18.3 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 KII61439.1 - 0.0048 17.5 0.0 0.015 16.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S28 PF05577.12 KII61439.1 - 0.0059 15.4 0.0 0.0064 15.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_2 PF02230.16 KII61439.1 - 0.0061 16.4 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 KII61439.1 - 0.024 14.2 0.1 4.1 6.9 0.0 2.1 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF2920 PF11144.8 KII61439.1 - 0.031 13.4 0.2 0.18 10.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) LIDHydrolase PF10230.9 KII61439.1 - 0.033 13.7 0.0 0.085 12.4 0.0 1.6 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase DPPIV_N PF00930.21 KII61440.1 - 8.3e-52 176.1 0.3 1.4e-51 175.3 0.3 1.4 1 1 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF1146 PF06612.11 KII61440.1 - 0.11 12.5 0.6 0.33 11.0 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1146) DUF4930 PF16284.5 KII61441.1 - 0.031 14.2 1.1 0.031 14.2 1.1 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4930) NPV_P10 PF05531.12 KII61441.1 - 1.6 9.3 10.2 0.12 12.8 0.6 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Na_H_Exchanger PF00999.21 KII61442.1 - 1.2e-44 152.7 26.7 1.4e-44 152.4 26.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF4131 PF13567.6 KII61442.1 - 8.5 6.0 11.5 0.45 10.2 1.0 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4131) rve PF00665.26 KII61443.1 - 1.3e-22 80.2 0.0 2.9e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61443.1 - 4.6e-15 55.5 2.5 1e-14 54.4 2.5 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII61443.1 - 0.0046 16.7 0.0 0.014 15.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 KII61444.1 - 6.9e-34 116.3 0.0 9.6e-34 115.8 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII61444.1 - 4.7e-27 93.9 0.0 7.4e-27 93.3 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RRM_1 PF00076.22 KII61445.1 - 5.8e-13 48.5 0.0 8.8e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KII61445.1 - 0.2 11.7 0.0 0.36 10.9 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif DDE_3 PF13358.6 KII61446.1 - 2.2e-10 40.5 0.0 3.3e-10 39.9 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease PABP PF00658.18 KII61446.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Poly-adenylate binding protein, unique domain HTH_33 PF13592.6 KII61447.1 - 0.0014 18.3 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII61447.1 - 0.0017 18.6 0.0 0.0039 17.4 0.0 1.6 1 0 0 1 1 1 1 Transposase Pico_P2B PF01552.17 KII61447.1 - 0.028 14.5 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 Picornavirus 2B protein Abhydrolase_1 PF00561.20 KII61448.1 - 1.6e-15 57.5 0.4 1.5e-14 54.3 0.2 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KII61448.1 - 4.2e-15 57.0 0.0 6.4e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KII61448.1 - 2.2e-09 36.9 0.0 4.1e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 KII61448.1 - 0.00012 20.9 0.0 0.00019 20.2 0.0 1.3 1 0 0 1 1 1 1 Ndr family Abhydro_lipase PF04083.16 KII61448.1 - 0.017 14.7 0.0 0.054 13.1 0.0 1.8 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region BAAT_C PF08840.11 KII61448.1 - 0.025 14.5 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1057 PF06342.12 KII61448.1 - 0.043 12.9 0.0 0.082 11.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Antirestrict PF03230.13 KII61448.1 - 0.12 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Antirestriction protein LIDHydrolase PF10230.9 KII61448.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase PGAP1 PF07819.13 KII61448.1 - 0.18 11.5 0.0 0.64 9.7 0.0 1.8 2 0 0 2 2 2 0 PGAP1-like protein RVT_1 PF00078.27 KII61450.1 - 1.2e-12 47.8 0.0 2.1e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII61450.1 - 8.3e-08 32.2 0.0 2.1e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Isochorismatase PF00857.20 KII61451.1 - 9.7e-25 87.7 0.3 4.9e-24 85.5 0.3 1.8 1 1 0 1 1 1 1 Isochorismatase family ALP_N PF17989.1 KII61452.1 - 0.008 16.4 0.0 0.012 15.8 0.0 1.2 1 0 0 1 1 1 1 Actin like proteins N terminal domain TFIIS_C PF01096.18 KII61452.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) His_Phos_2 PF00328.22 KII61453.1 - 2.1e-20 73.4 0.0 7.8e-20 71.6 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.22 KII61454.1 - 2e-14 53.7 1.4 2.7e-14 53.3 1.4 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) N2227 PF07942.12 KII61454.1 - 0.011 15.0 0.6 0.018 14.2 0.4 1.3 1 1 0 1 1 1 0 N2227-like protein Pkinase PF00069.25 KII61455.1 - 1.1e-38 133.1 0.0 1.3e-38 132.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII61455.1 - 8.1e-26 90.8 0.0 1e-25 90.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KII61455.1 - 2.1e-06 26.8 0.0 2.4e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KII61455.1 - 0.042 13.2 0.0 0.086 12.1 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Ribosomal_L7Ae PF01248.26 KII61456.1 - 1e-19 70.0 0.0 1.3e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Importin_rep_4 PF18808.1 KII61459.1 - 1.6e-13 50.7 0.7 2.2e-12 47.1 0.6 2.7 2 0 0 2 2 2 1 Importin repeat HEAT_EZ PF13513.6 KII61459.1 - 4.8e-07 30.1 0.1 1.1e-05 25.8 0.0 3.5 5 0 0 5 5 5 1 HEAT-like repeat HEAT PF02985.22 KII61459.1 - 5.9e-07 29.2 0.4 0.094 13.0 0.0 4.3 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 KII61459.1 - 7.3e-06 26.3 0.0 0.024 15.0 0.0 3.8 3 1 0 3 3 3 1 HEAT repeats Vac14_Fab1_bd PF12755.7 KII61459.1 - 0.0011 19.6 3.8 0.096 13.3 0.0 3.8 4 1 0 5 5 5 1 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 KII61459.1 - 0.0027 17.6 1.4 0.19 11.7 0.3 3.6 4 1 0 4 4 4 1 Importin-beta N-terminal domain RIX1 PF08167.12 KII61459.1 - 0.0043 16.8 1.5 0.24 11.1 0.1 2.6 2 1 1 3 3 3 1 rRNA processing/ribosome biogenesis Syntaxin_2 PF14523.6 KII61459.1 - 0.0047 17.3 0.9 0.031 14.6 0.0 2.7 3 0 0 3 3 3 1 Syntaxin-like protein Arm PF00514.23 KII61459.1 - 0.12 12.5 1.9 17 5.6 0.0 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 KII61459.1 - 0.13 12.4 2.2 9.3 6.5 0.0 3.7 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 KII61460.1 - 7.9e-07 28.9 0.0 0.00026 20.6 0.0 3.1 2 1 1 3 3 3 2 CLASP N terminal DUF3385 PF11865.8 KII61460.1 - 4.3e-06 26.7 0.7 1.8 8.5 0.0 4.6 3 2 2 5 5 5 2 Domain of unknown function (DUF3385) HEAT PF02985.22 KII61460.1 - 1.9e-05 24.5 5.5 0.039 14.2 0.0 4.8 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 KII61460.1 - 0.00041 20.8 0.1 0.22 12.0 0.0 3.8 4 0 0 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 KII61460.1 - 0.018 15.7 0.2 4.4 8.0 0.0 3.4 3 2 0 3 3 3 0 Vacuolar 14 Fab1-binding region DHC_N1 PF08385.12 KII61460.1 - 0.06 12.0 0.3 0.089 11.4 0.3 1.2 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 Cohesin_HEAT PF12765.7 KII61460.1 - 0.11 12.8 0.6 0.41 11.0 0.1 2.2 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion EGF_2 PF07974.13 KII61462.1 - 0.0062 16.9 10.7 0.0062 16.9 10.7 4.9 3 2 1 4 4 4 2 EGF-like domain DSL PF01414.19 KII61462.1 - 0.018 15.3 38.9 0.029 14.6 5.8 3.8 2 2 1 3 3 3 0 Delta serrate ligand Hexokinase_2 PF03727.16 KII61468.1 - 1.6e-56 191.5 0.1 5e-56 189.8 0.1 1.7 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII61468.1 - 2.5e-31 109.1 0.0 3.7e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 Hexokinase SapB_1 PF05184.15 KII61468.1 - 0.48 10.5 2.6 25 5.0 0.6 3.0 2 0 0 2 2 2 0 Saposin-like type B, region 1 Diphthamide_syn PF01866.17 KII61469.1 - 2.9e-17 63.1 0.0 4e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein zf-DNL PF05180.12 KII61469.1 - 0.04 13.8 0.0 0.076 13.0 0.0 1.5 1 0 0 1 1 1 0 DNL zinc finger CwfJ_C_1 PF04677.15 KII61470.1 - 2.6e-12 46.7 0.5 4.5e-12 45.9 0.5 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 TAFII28 PF04719.14 KII61471.1 - 8.2e-20 70.7 0.0 9.4e-20 70.5 0.0 1.1 1 0 0 1 1 1 1 hTAFII28-like protein conserved region Histone PF00125.24 KII61471.1 - 0.00088 19.6 0.0 0.0011 19.3 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KII61471.1 - 0.0032 17.7 2.3 0.0035 17.6 0.7 1.8 1 1 1 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF5101 PF17031.5 KII61472.1 - 0.024 14.7 0.0 0.027 14.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) OrsD PF12013.8 KII61473.1 - 0.025 15.0 0.0 0.04 14.4 0.0 1.3 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D EF1_GNE PF00736.19 KII61474.1 - 9.4e-24 83.4 4.2 9.4e-24 83.4 4.2 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain Allexi_40kDa PF05549.11 KII61474.1 - 0.0021 17.6 0.1 0.0037 16.8 0.1 1.4 1 0 0 1 1 1 1 Allexivirus 40kDa protein DUF16 PF01519.16 KII61474.1 - 0.018 15.5 0.8 0.11 13.0 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function DUF16 LPD3 PF18798.1 KII61474.1 - 0.022 15.0 0.1 0.041 14.1 0.1 1.5 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 3 SpoVR PF04293.13 KII61474.1 - 0.22 10.1 0.1 0.27 9.9 0.1 1.1 1 0 0 1 1 1 0 SpoVR like protein WD40 PF00400.32 KII61475.1 - 0.0033 18.2 3.8 2.4 9.2 0.6 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Collagen PF01391.18 KII61476.1 - 4e-06 26.5 15.3 6.6e-06 25.8 15.3 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Adaptin_binding PF10199.9 KII61476.1 - 0.81 10.3 13.3 1.6 9.3 10.1 2.4 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Helo_like_N PF17111.5 KII61476.1 - 2.2 7.6 7.2 0.11 11.8 0.9 2.1 3 0 0 3 3 3 0 Fungal N-terminal domain of STAND proteins Pkinase PF00069.25 KII61478.1 - 5.4e-66 222.7 0.0 6.2e-66 222.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII61478.1 - 7.1e-29 100.9 0.0 9e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII61478.1 - 1.6e-05 24.4 0.0 0.12 11.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 KII61478.1 - 0.00032 19.7 0.0 0.00053 19.0 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KII61478.1 - 0.049 12.4 0.1 1.2 7.9 0.1 2.0 2 0 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 KII61478.1 - 0.24 11.0 0.4 4.9 6.7 0.1 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Mito_carr PF00153.27 KII61479.1 - 2.6e-44 149.1 5.8 2.8e-19 68.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_39 PF01229.17 KII61481.1 - 0.076 11.6 0.0 0.076 11.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 DUF4607 PF15380.6 KII61481.1 - 0.15 11.6 0.0 0.2 11.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4607) EF-hand_7 PF13499.6 KII61482.1 - 1.3e-11 44.7 0.1 7.6e-08 32.7 0.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KII61482.1 - 1.2e-09 37.3 0.4 0.001 18.8 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KII61482.1 - 5.4e-07 28.7 0.1 0.029 13.9 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KII61482.1 - 0.00053 19.8 0.0 0.073 12.9 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_11 PF08976.11 KII61482.1 - 0.032 15.1 0.0 0.042 14.7 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_14 PF17959.1 KII61482.1 - 0.058 13.7 0.0 1.6 9.1 0.0 2.2 1 1 1 2 2 2 0 EF-hand domain GPHH PF16905.5 KII61482.1 - 0.07 12.9 0.0 3.3 7.5 0.0 2.5 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Bromodomain PF00439.25 KII61483.1 - 7.6e-23 80.4 2.5 7.6e-23 80.4 2.5 3.2 3 0 0 3 3 3 1 Bromodomain PHD PF00628.29 KII61483.1 - 3.2e-08 33.3 27.5 0.00036 20.4 6.1 2.7 2 0 0 2 2 2 2 PHD-finger WSD PF15613.6 KII61483.1 - 1.6e-05 25.3 2.9 0.00013 22.4 2.9 2.6 1 1 0 1 1 1 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif MBD PF01429.19 KII61483.1 - 2.4e-05 23.9 0.0 7.7e-05 22.3 0.0 1.9 1 0 0 1 1 1 1 Methyl-CpG binding domain DDT PF02791.17 KII61483.1 - 0.027 14.8 0.3 0.2 12.0 0.7 2.4 2 0 0 2 2 2 0 DDT domain PHD_2 PF13831.6 KII61483.1 - 0.15 11.6 19.7 0.11 12.1 1.6 3.4 4 0 0 4 4 4 0 PHD-finger Qua1 PF16274.5 KII61483.1 - 0.81 9.6 5.0 9.4 6.2 0.0 4.3 4 0 0 4 4 4 0 Qua1 domain C1_1 PF00130.22 KII61483.1 - 2.5 8.0 27.7 0.52 10.2 3.8 3.1 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4446 PF14584.6 KII61483.1 - 5.4 7.0 7.7 1.8 8.5 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) P34-Arc PF04045.14 KII61485.1 - 5.4e-45 154.0 0.0 7.1e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc nsp9 PF08710.10 KII61485.1 - 0.046 14.1 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 nsp9 replicase CoaE PF01121.20 KII61486.1 - 1.4e-33 116.0 0.0 2.5e-33 115.2 0.0 1.4 1 0 0 1 1 1 1 Dephospho-CoA kinase CTP_transf_like PF01467.26 KII61486.1 - 2.2e-07 31.2 0.2 1.5e-06 28.5 0.0 2.3 2 1 0 2 2 2 1 Cytidylyltransferase-like AAA_18 PF13238.6 KII61486.1 - 0.00014 22.4 2.0 0.0014 19.1 1.0 2.9 2 1 0 2 2 2 1 AAA domain FAD_syn PF06574.12 KII61486.1 - 0.036 14.0 0.6 0.17 11.8 0.3 2.0 1 1 1 2 2 2 0 FAD synthetase Guanylate_kin PF00625.21 KII61487.1 - 2.9e-17 62.9 0.0 3.2e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase TPR_1 PF00515.28 KII61488.1 - 0.00013 21.6 0.5 0.0016 18.2 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII61488.1 - 0.035 14.3 0.4 0.33 11.3 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII61488.1 - 0.067 13.3 1.5 0.2 11.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_9 PF14580.6 KII61490.1 - 3.7e-61 205.6 3.4 5e-61 205.2 3.4 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KII61490.1 - 1.8e-07 31.4 14.8 0.0037 17.7 4.3 3.8 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KII61490.1 - 1.3e-06 28.1 13.9 4.7e-06 26.3 5.8 3.4 3 2 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 KII61490.1 - 0.62 10.3 5.6 69 3.9 0.5 4.1 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 KII61490.1 - 6.9 7.6 8.8 64 4.7 0.9 4.2 2 2 0 2 2 2 0 Leucine Rich Repeat GNAT_acetyltr_2 PF13718.6 KII61491.1 - 8.5e-86 287.0 0.0 1.9e-85 285.9 0.0 1.6 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 KII61491.1 - 8.9e-56 188.5 0.0 1.8e-55 187.5 0.0 1.6 1 0 0 1 1 1 1 Helicase tRNA_bind_2 PF13725.6 KII61491.1 - 1.1e-46 159.5 2.0 1.8e-46 158.7 2.0 1.3 1 0 0 1 1 1 1 Possible tRNA binding domain DUF1726 PF08351.11 KII61491.1 - 2.6e-28 97.8 0.2 7.7e-28 96.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 KII61491.1 - 0.00095 19.4 0.1 0.025 14.8 0.0 2.8 2 1 1 3 3 3 1 AAA domain DUF4518 PF15008.6 KII61492.1 - 0.067 12.4 1.0 0.12 11.6 0.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) DUF5572 PF17733.1 KII61492.1 - 0.4 10.5 0.2 0.4 10.5 0.2 1.9 2 1 0 2 2 2 0 Family of unknown function (DUF5572) Ribosomal_L5e PF17144.4 KII61493.1 - 2.8e-75 251.8 1.8 4.6e-75 251.1 1.8 1.3 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 KII61493.1 - 1.2e-26 93.5 5.6 1.2e-26 93.5 5.6 2.0 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region EGF_2 PF07974.13 KII61495.1 - 0.0042 17.4 10.0 0.0042 17.4 10.0 3.3 3 1 0 3 3 3 1 EGF-like domain DUF2957 PF11170.8 KII61495.1 - 7.7 5.2 6.0 7.7 5.2 2.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2957) Actin PF00022.19 KII61497.1 - 8.4e-152 505.5 0.0 2.7e-151 503.8 0.0 1.6 1 1 0 1 1 1 1 Actin Pox_A_type_inc PF04508.12 KII61498.1 - 0.038 13.9 0.7 0.088 12.7 0.7 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat ANAPC4_WD40 PF12894.7 KII61499.1 - 3.6e-09 36.8 0.0 0.015 15.6 0.0 4.7 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KII61499.1 - 4e-06 26.4 0.4 0.025 13.9 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain WD40 PF00400.32 KII61499.1 - 4.7e-05 24.1 1.6 2.8 8.9 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 KII61499.1 - 0.092 12.0 0.0 3.3 6.9 0.0 2.7 1 1 2 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Ank_2 PF12796.7 KII61501.1 - 5.2e-23 81.4 2.5 3.5e-11 43.5 0.1 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KII61501.1 - 3.6e-11 43.0 0.5 0.012 16.1 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KII61501.1 - 4.3e-11 43.1 0.3 6.6e-06 26.6 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII61501.1 - 3.4e-10 39.2 1.8 0.018 15.5 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 KII61501.1 - 9.9e-08 32.1 0.5 0.0022 18.3 0.0 3.1 1 1 3 4 4 4 3 Ankyrin repeats (many copies) YcbB PF08664.10 KII61501.1 - 0.0063 16.6 0.1 0.02 15.0 0.1 1.8 2 0 0 2 2 2 1 YcbB domain FOXO-TAD PF16676.5 KII61501.1 - 3.6 8.1 6.7 1.4 9.4 3.7 1.8 2 0 0 2 2 2 0 Transactivation domain of FOXO protein family zf-C3HC4_3 PF13920.6 KII61502.1 - 2.1e-08 33.9 7.3 3.7e-08 33.1 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 KII61502.1 - 1.3e-07 31.3 2.4 1.3e-07 31.3 2.4 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_UBOX PF13445.6 KII61502.1 - 4e-07 30.0 10.7 7.4e-07 29.1 10.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KII61502.1 - 7.7e-07 28.8 11.8 1.3e-06 28.1 11.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KII61502.1 - 1.6e-06 27.9 13.5 2.9e-06 27.1 13.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII61502.1 - 3.3e-06 27.3 10.4 6.4e-06 26.4 10.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf_CCCH_4 PF18345.1 KII61502.1 - 0.00013 21.9 4.7 0.00037 20.4 4.7 1.9 1 0 0 1 1 1 1 Zinc finger domain zf-C3HC4_4 PF15227.6 KII61502.1 - 0.00024 21.2 8.7 0.00053 20.1 8.7 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KII61502.1 - 0.0003 20.7 12.5 0.00057 19.8 12.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 KII61502.1 - 0.00099 18.9 5.3 0.0016 18.2 5.3 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-CCCH_4 PF18044.1 KII61502.1 - 0.0046 16.7 3.6 0.0046 16.7 3.6 2.2 2 0 0 2 2 1 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 KII61502.1 - 0.03 14.2 8.5 0.057 13.3 8.5 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-CCCH_2 PF14608.6 KII61502.1 - 0.032 14.7 2.0 0.096 13.2 2.0 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Cript PF10235.9 KII61502.1 - 0.061 13.9 8.6 0.15 12.7 8.5 1.9 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT HNHc_6 PF16784.5 KII61502.1 - 0.1 12.1 0.3 0.15 11.6 0.3 1.2 1 0 0 1 1 1 0 Putative HNHc nuclease IRK_N PF08466.10 KII61502.1 - 0.15 12.3 0.2 0.33 11.1 0.2 1.5 1 0 0 1 1 1 0 Inward rectifier potassium channel N-terminal zf-RING_11 PF17123.5 KII61502.1 - 0.17 11.6 5.1 0.43 10.4 5.1 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_10 PF16685.5 KII61502.1 - 0.24 11.6 9.0 0.11 12.6 6.4 1.8 2 0 0 2 2 1 0 zinc RING finger of MSL2 Zn_ribbon_17 PF17120.5 KII61502.1 - 0.82 9.3 9.2 0.3 10.7 6.5 1.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_6 PF14835.6 KII61502.1 - 1.2 9.0 4.4 2.3 8.2 4.4 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 KII61502.1 - 2.8 8.3 12.3 14 6.1 12.3 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain GTP_EFTU_D3 PF03143.17 KII61504.1 - 3.8e-13 49.7 0.0 6.6e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 KII61504.1 - 1.6e-06 27.8 0.0 2.1e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KII61504.1 - 0.11 11.8 0.2 0.17 11.2 0.2 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region E1_DerP2_DerF2 PF02221.15 KII61507.1 - 0.01 16.3 0.7 0.06 13.8 0.7 1.9 1 1 0 1 1 1 0 ML domain RE_BsaWI PF18643.1 KII61507.1 - 0.15 12.0 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 BsaWI restriction endonuclease type 2 DDE_Tnp_IS1595 PF12762.7 KII61508.1 - 1.1e-06 28.7 0.0 2.7e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain DNA_pol_E_B PF04042.16 KII61508.1 - 0.027 13.8 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B DUF1882 PF08966.11 KII61511.1 - 0.14 12.4 0.3 0.22 11.8 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) Ank_5 PF13857.6 KII61512.1 - 3e-07 30.6 0.0 0.00025 21.3 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII61512.1 - 3.8e-06 26.8 0.0 2.7e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 KII61512.1 - 1.5e-05 25.5 0.0 0.00049 20.6 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII61512.1 - 0.0001 22.8 0.1 0.0022 18.5 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Helicase_C PF00271.31 KII61513.1 - 1.7e-31 108.9 0.0 6.9e-31 106.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KII61513.1 - 3.8e-19 69.1 0.0 6.4e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 KII61513.1 - 0.022 14.0 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase TniB PF05621.11 KII61513.1 - 0.046 13.1 0.0 0.098 12.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein CMS1 PF14617.6 KII61513.1 - 0.095 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 KII61513.1 - 0.15 12.4 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Calcipressin PF04847.12 KII61514.1 - 1.5e-09 37.9 0.0 2e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Calcipressin MULE PF10551.9 KII61515.1 - 2.3e-07 31.1 0.1 3.2e-06 27.5 0.1 2.5 1 1 0 1 1 1 1 MULE transposase domain DDE_Tnp_IS1595 PF12762.7 KII61517.1 - 0.0026 17.8 0.3 0.0034 17.4 0.3 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain HECT PF00632.25 KII61518.1 - 2.5e-91 306.4 0.8 3.3e-91 306.0 0.8 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KII61518.1 - 4.7e-16 58.6 6.2 1.5e-07 31.4 0.2 2.9 3 0 0 3 3 3 2 WW domain hDGE_amylase PF14701.6 KII61519.1 - 4.7e-123 411.5 0.9 6.7e-123 411.0 0.9 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain hGDE_N PF14699.6 KII61519.1 - 1.2e-07 31.7 0.3 2.6e-07 30.7 0.3 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 KII61519.1 - 9e-06 25.5 0.4 0.00021 21.0 0.1 2.3 2 0 0 2 2 2 1 Alpha amylase, catalytic domain hGDE_central PF14702.6 KII61520.1 - 2.4e-16 60.2 1.1 1.8e-15 57.3 1.1 1.9 1 1 0 1 1 1 1 Central domain of human glycogen debranching enzyme TFIIA PF03153.13 KII61521.1 - 6.4 6.7 16.5 10 6.0 16.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDE_Tnp_IS1595 PF12762.7 KII61524.1 - 3.7e-19 69.2 0.0 4.4e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain RFX_DNA_binding PF02257.15 KII61525.1 - 2.2e-21 76.3 2.4 3.3e-21 75.7 0.1 2.6 3 0 0 3 3 3 1 RFX DNA-binding domain Ldl_recept_a PF00057.18 KII61526.1 - 4.2e-36 122.9 112.8 6.2e-10 39.1 5.9 8.2 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A Serpin PF00079.20 KII61528.1 - 1.3e-27 97.1 2.0 1.6e-27 96.8 2.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CDT1 PF08839.11 KII61529.1 - 1.9e-35 122.8 0.3 5.2e-35 121.3 0.3 1.8 1 0 0 1 1 1 1 DNA replication factor CDT1 like CDT1_C PF16679.5 KII61529.1 - 6.5e-05 23.3 0.2 0.00021 21.7 0.2 1.9 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain RL10P_insert PF17777.1 KII61530.1 - 2.6e-13 49.7 0.1 4.7e-13 48.9 0.1 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 KII61530.1 - 1.3e-12 47.7 0.1 1.9e-12 47.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_L4 PF00573.22 KII61530.1 - 0.049 13.3 0.2 0.068 12.8 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family Mlh1_C PF16413.5 KII61532.1 - 2.2e-47 161.7 7.2 4e-46 157.6 7.2 2.6 1 1 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 KII61532.1 - 2.1e-24 85.5 0.5 6.4e-24 83.9 0.1 2.1 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KII61532.1 - 1.5e-14 53.9 0.2 9.4e-14 51.4 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KII61532.1 - 0.00036 21.0 0.0 0.0011 19.4 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MULE PF10551.9 KII61533.1 - 3.2e-11 43.5 0.1 5.2e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 MULE transposase domain DUF1955 PF09205.10 KII61533.1 - 0.19 11.5 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) MHB PF16525.5 KII61535.1 - 0.00076 19.7 0.1 0.0013 19.0 0.1 1.3 1 0 0 1 1 1 1 Haemophore, haem-binding RVT_1 PF00078.27 KII61537.1 - 0.029 13.9 0.1 0.092 12.2 0.0 1.9 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-U11-48K PF05253.12 KII61537.1 - 0.12 12.4 0.7 0.37 10.8 0.7 1.9 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger Folate_rec PF03024.14 KII61538.1 - 5.8e-10 39.3 2.6 6.2e-10 39.2 2.6 1.0 1 0 0 1 1 1 1 Folate receptor family Adaptin_binding PF10199.9 KII61539.1 - 2.2e-07 31.5 4.2 0.00029 21.4 1.4 2.4 1 1 1 2 2 2 2 Alpha and gamma adaptin binding protein p34 RRM_1 PF00076.22 KII61540.1 - 1.5e-26 92.0 0.1 1.1e-15 57.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII61540.1 - 6e-06 26.3 0.0 6.4e-05 23.0 0.0 2.6 2 1 1 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KII61540.1 - 3.3e-05 23.8 0.0 0.0016 18.4 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KII61540.1 - 0.0082 16.2 1.2 0.036 14.1 0.0 2.4 3 0 0 3 3 3 1 RNA binding motif OB_RNB PF08206.11 KII61540.1 - 0.032 13.9 0.1 5.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain DDE_Tnp_IS1595 PF12762.7 KII61542.1 - 1.1e-05 25.5 0.1 2.5e-05 24.3 0.0 1.6 1 1 1 2 2 2 1 ISXO2-like transposase domain UbiA PF01040.18 KII61543.1 - 1.5e-39 135.8 13.7 2e-39 135.4 13.7 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family Vps23_core PF09454.10 KII61544.1 - 3.2e-09 36.6 0.0 6.5e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Vps23 core domain UEV PF05743.13 KII61544.1 - 1.4e-05 24.9 0.0 3.3e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 UEV domain FAM60A PF15396.6 KII61545.1 - 2 8.4 4.0 3.3 7.6 3.9 1.6 1 1 0 1 1 1 0 Protein Family FAM60A VWA PF00092.28 KII61547.1 - 0.00012 22.4 0.4 0.00016 22.0 0.4 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain DNA_photolyase PF00875.18 KII61547.1 - 0.039 14.0 0.3 0.081 12.9 0.1 1.6 2 0 0 2 2 2 0 DNA photolyase RT_RNaseH_2 PF17919.1 KII61548.1 - 1e-35 121.7 0.0 3.4e-35 120.1 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61548.1 - 1e-32 112.5 0.0 2.5e-32 111.3 0.0 1.7 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII61548.1 - 6.1e-21 75.0 0.0 1.4e-20 73.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4129 PF13559.6 KII61549.1 - 0.0083 16.4 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) SLED PF12140.8 KII61549.1 - 0.16 12.5 2.6 1.4 9.4 0.1 2.7 3 0 0 3 3 3 0 SLED domain PIH1 PF08190.12 KII61550.1 - 5.5e-12 45.5 0.0 1e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 PIH1 N-terminal domain Ank_4 PF13637.6 KII61551.1 - 7.7e-09 35.9 0.1 2.9e-06 27.7 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KII61551.1 - 8.1e-09 35.6 0.0 1.6e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KII61551.1 - 9.9e-09 35.3 0.0 1.1e-07 32.0 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 KII61551.1 - 6.5e-07 29.8 0.0 1.6e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KII61551.1 - 2.5e-05 24.3 0.1 0.00069 19.9 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeat PEGA PF08308.11 KII61551.1 - 0.17 11.8 0.0 4.4 7.3 0.0 2.1 1 1 1 2 2 2 0 PEGA domain Ank_4 PF13637.6 KII61552.1 - 0.00011 22.7 0.0 0.00025 21.5 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII61552.1 - 0.017 15.6 0.1 1.2 10.0 0.0 2.9 2 1 1 3 3 3 0 Ankyrin repeat Ank_2 PF12796.7 KII61552.1 - 0.029 14.9 0.0 0.11 13.2 0.0 1.8 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) FAM60A PF15396.6 KII61553.1 - 2.2e-05 24.5 3.9 2.7e-05 24.3 0.0 2.0 1 1 1 2 2 2 1 Protein Family FAM60A FAM91_C PF14648.6 KII61554.1 - 1.8e-32 112.8 1.2 2.8e-32 112.1 1.2 1.3 1 0 0 1 1 1 1 FAM91 C-terminus FAM91_N PF14647.6 KII61554.1 - 2.1e-22 79.8 0.5 3.3e-22 79.2 0.1 1.6 2 0 0 2 2 2 1 FAM91 N-terminus Phage_rep_org_N PF09681.10 KII61554.1 - 0.034 14.1 1.4 0.048 13.6 0.2 1.8 2 0 0 2 2 2 0 N-terminal phage replisome organiser (Phage_rep_org_N) FAM91_C PF14648.6 KII61555.1 - 1.9e-45 155.5 2.5 9e-43 146.7 2.5 2.1 1 1 0 1 1 1 1 FAM91 C-terminus FGGY_N PF00370.21 KII61556.1 - 7.5e-27 94.5 0.1 9.3e-27 94.1 0.1 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Ribosomal_S4e PF00900.20 KII61558.1 - 1.1e-34 118.2 0.1 5.4e-34 115.9 0.3 2.0 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 KII61558.1 - 2.4e-21 75.1 0.1 4.9e-21 74.1 0.1 1.6 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus KOW PF00467.29 KII61558.1 - 7.5e-07 28.9 2.4 2.5e-06 27.3 0.4 2.6 2 0 0 2 2 2 1 KOW motif Sipho_tail PF05709.11 KII61558.1 - 0.031 13.7 0.0 0.048 13.1 0.0 1.4 1 1 0 1 1 1 0 Phage tail protein zf-tcix PF14952.6 KII61559.1 - 0.097 12.3 0.3 0.097 12.3 0.3 1.8 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zf-A20 PF01754.16 KII61559.1 - 0.45 10.5 6.6 0.75 9.8 0.5 2.5 2 0 0 2 2 2 0 A20-like zinc finger RT_RNaseH_2 PF17919.1 KII61560.1 - 4.5e-36 122.9 0.0 9.8e-36 121.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61560.1 - 5.1e-36 123.1 0.0 1.3e-35 121.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII61560.1 - 3.9e-20 71.7 0.4 8.8e-20 70.6 0.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII61560.1 - 1.1e-17 64.3 0.0 2.5e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII61560.1 - 2.9e-05 24.2 0.3 9e-05 22.6 0.3 1.9 1 0 0 1 1 1 1 H2C2 zinc finger Methyltransf_25 PF13649.6 KII61560.1 - 0.00018 22.2 0.0 0.0004 21.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 KII61560.1 - 0.00033 20.4 0.0 0.092 12.4 0.0 2.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 rve_3 PF13683.6 KII61560.1 - 0.00058 19.6 0.0 0.0029 17.3 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Methyltransf_31 PF13847.6 KII61560.1 - 0.0038 17.0 0.0 0.018 14.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain N6_N4_Mtase PF01555.18 KII61560.1 - 0.094 12.4 0.0 0.3 10.8 0.0 1.8 1 0 0 1 1 1 0 DNA methylase DUF3172 PF11371.8 KII61560.1 - 0.13 12.0 0.0 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3172) PYRIN PF02758.16 KII61562.1 - 0.0062 16.6 0.2 0.024 14.8 0.0 2.0 1 1 1 2 2 2 1 PAAD/DAPIN/Pyrin domain PHD PF00628.29 KII61563.1 - 5.2e-06 26.3 10.0 9.4e-06 25.4 10.0 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 KII61563.1 - 0.087 13.1 6.9 0.21 11.8 6.9 1.7 1 1 0 1 1 1 0 PHD-like zinc-binding domain Kelch_4 PF13418.6 KII61569.1 - 2.1e-10 40.4 1.3 0.00085 19.3 0.1 4.2 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KII61569.1 - 3.7e-10 39.7 7.4 0.002 18.4 0.1 4.3 4 1 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KII61569.1 - 1.7e-09 37.1 10.8 0.0018 17.8 0.5 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 KII61569.1 - 2.3e-09 37.3 1.5 0.0003 21.0 0.1 3.7 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII61569.1 - 1.9e-08 33.9 8.8 0.057 13.4 0.0 4.6 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 KII61569.1 - 0.038 14.0 13.0 0.12 12.4 0.1 3.4 5 0 0 5 5 5 0 Kelch motif NmrA PF05368.13 KII61574.1 - 0.19 11.3 0.0 0.42 10.1 0.0 1.6 1 1 0 1 1 1 0 NmrA-like family Cut8 PF08559.10 KII61577.1 - 0.014 15.0 0.1 0.033 13.8 0.0 1.6 1 1 1 2 2 2 0 Cut8, nuclear proteasome tether protein TACI-CRD2 PF09305.10 KII61583.1 - 0.35 10.9 5.2 0.21 11.6 0.5 2.3 2 0 0 2 2 2 0 TACI, cysteine-rich domain RVP PF00077.20 KII61584.1 - 0.0097 16.2 0.0 0.028 14.7 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII61584.1 - 0.0099 16.4 0.0 0.075 13.6 0.0 2.4 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease TFIIF_beta PF02270.15 KII61586.1 - 5.2e-17 61.7 0.0 9.3e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Importin_rep PF18773.1 KII61586.1 - 0.44 10.3 2.1 0.58 9.9 0.2 2.1 2 0 0 2 2 2 0 Importin 13 repeat BSD PF03909.17 KII61587.1 - 0.0036 17.3 0.8 0.0096 15.9 0.0 2.1 2 1 1 3 3 3 1 BSD domain Cyclin_N PF00134.23 KII61589.1 - 5.7e-07 29.3 1.4 8.3e-07 28.8 1.4 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Exo70 PF03081.15 KII61590.1 - 2.5e-08 33.4 1.3 3e-08 33.1 1.3 1.0 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Fib_alpha PF08702.10 KII61590.1 - 0.016 15.4 2.2 0.018 15.2 2.2 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Cpn60_TCP1 PF00118.24 KII61590.1 - 0.074 11.7 0.3 0.082 11.5 0.3 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family AChE_tetra PF08674.10 KII61590.1 - 0.08 12.6 0.4 0.83 9.4 0.2 2.1 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain NleF_casp_inhib PF16809.5 KII61591.1 - 0.0079 16.1 0.1 0.013 15.5 0.1 1.4 1 1 0 1 1 1 1 NleF caspase inhibitor AdoHcyase PF05221.17 KII61591.1 - 0.011 14.9 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase Integrin_alpha2 PF08441.12 KII61592.1 - 7.3e-20 71.3 0.0 1.6e-19 70.1 0.0 1.5 1 1 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 KII61592.1 - 6.7e-06 26.1 0.0 1.4e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 FG-GAP repeat DUF368 PF04018.13 KII61593.1 - 0.013 15.1 1.3 0.016 14.8 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF368) COX2_TM PF02790.15 KII61593.1 - 0.096 12.8 0.2 0.14 12.3 0.2 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain EamA PF00892.20 KII61593.1 - 0.1 12.8 6.1 0.12 12.5 6.1 1.1 1 0 0 1 1 1 0 EamA-like transporter family DUF2871 PF11070.8 KII61593.1 - 0.18 12.0 3.6 0.24 11.7 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) DUF3413 PF11893.8 KII61593.1 - 2.8 7.1 8.1 3.6 6.7 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) IU_nuc_hydro PF01156.19 KII61596.1 - 2.6e-45 155.3 0.0 3.1e-45 155.1 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DDE_3 PF13358.6 KII61597.1 - 0.00078 19.2 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Transglut_N PF00868.20 KII61598.1 - 3.5e-06 27.4 0.0 5.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase family Ribosomal_L36 PF00444.18 KII61598.1 - 0.3 11.3 1.1 0.73 10.1 1.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L36 IU_nuc_hydro PF01156.19 KII61600.1 - 9.2e-39 133.8 0.0 2.7e-38 132.3 0.0 1.6 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF1904 PF08921.11 KII61601.1 - 0.049 13.9 0.7 0.19 12.0 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1904) RVT_1 PF00078.27 KII61603.1 - 0.00056 19.5 0.0 0.0012 18.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MbeB_N PF04837.12 KII61604.1 - 0.047 14.0 0.2 0.091 13.1 0.2 1.5 1 0 0 1 1 1 0 MbeB-like, N-term conserved region Sec63 PF02889.16 KII61605.1 - 1e-05 24.8 0.0 1.3e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain DWNN PF08783.11 KII61605.1 - 0.2 12.0 0.4 0.33 11.3 0.4 1.3 1 0 0 1 1 1 0 DWNN domain DnaJ PF00226.31 KII61606.1 - 8.5e-10 38.6 0.0 1.5e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain zf-LITAF-like PF10601.9 KII61606.1 - 0.08 13.2 0.3 0.08 13.2 0.3 2.3 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain AgrB PF04647.15 KII61606.1 - 0.21 10.9 7.1 0.4 10.0 7.1 1.5 1 1 0 1 1 1 0 Accessory gene regulator B RVP_2 PF08284.11 KII61607.1 - 4.4e-09 36.2 0.0 1.7e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII61607.1 - 5e-07 30.2 0.0 1.4e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII61607.1 - 9.8e-07 28.6 0.1 3.4e-06 26.9 0.1 1.8 1 1 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII61607.1 - 1.2e-05 25.5 0.0 2.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII61607.1 - 9.1e-05 23.0 0.0 0.00026 21.6 0.0 1.8 1 1 0 1 1 1 1 Aspartyl protease Peptidase_A3 PF02160.15 KII61607.1 - 0.007 15.9 0.0 0.016 14.7 0.0 1.5 1 0 0 1 1 1 1 Cauliflower mosaic virus peptidase (A3) zf-CCHC_4 PF14392.6 KII61607.1 - 0.021 14.6 2.1 0.047 13.4 2.1 1.6 1 0 0 1 1 1 0 Zinc knuckle FYVE_2 PF02318.16 KII61607.1 - 0.056 13.7 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger zf-CCHC_6 PF15288.6 KII61607.1 - 0.26 11.2 4.8 0.51 10.2 4.8 1.5 1 0 0 1 1 1 0 Zinc knuckle Orthoreo_P17 PF07272.11 KII61608.1 - 0.0039 17.2 0.3 0.0047 16.9 0.3 1.1 1 0 0 1 1 1 1 Orthoreovirus P17 protein PAH PF02671.21 KII61608.1 - 0.021 14.9 0.9 0.042 14.0 0.9 1.6 1 0 0 1 1 1 0 Paired amphipathic helix repeat FPP PF05911.11 KII61612.1 - 2.8e-06 25.9 14.1 3.8e-06 25.4 14.1 1.3 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil GAS PF13851.6 KII61612.1 - 3.6e-05 23.2 20.4 0.00036 20.0 4.3 2.5 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 KII61612.1 - 4e-05 23.7 23.0 0.01 15.9 8.2 2.4 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cluap1 PF10234.9 KII61612.1 - 4.3e-05 23.0 15.0 0.00059 19.3 4.1 2.1 1 1 1 2 2 2 2 Clusterin-associated protein-1 Tektin PF03148.14 KII61612.1 - 0.00022 20.1 4.7 0.00022 20.1 4.7 2.7 1 1 0 2 2 2 1 Tektin family Spc7 PF08317.11 KII61612.1 - 0.00035 19.6 21.4 0.016 14.1 10.5 2.2 1 1 1 2 2 2 2 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 KII61612.1 - 0.0022 18.2 3.8 0.0022 18.2 3.8 3.1 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding Baculo_PEP_C PF04513.12 KII61612.1 - 0.0023 18.0 14.1 0.11 12.5 4.0 2.3 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2353 PF09789.9 KII61612.1 - 0.0048 16.3 6.8 0.0048 16.3 6.8 2.1 1 1 1 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) Rootletin PF15035.6 KII61612.1 - 0.0052 16.8 20.1 0.11 12.6 3.4 2.2 1 1 1 2 2 2 2 Ciliary rootlet component, centrosome cohesion Fez1 PF06818.15 KII61612.1 - 0.0053 17.2 17.1 0.15 12.5 4.7 2.3 1 1 1 2 2 2 2 Fez1 FTHFS PF01268.19 KII61612.1 - 0.0077 14.5 1.5 0.011 14.0 1.5 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase APG6_N PF17675.1 KII61612.1 - 0.012 16.2 21.7 0.029 14.9 5.8 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region MHCassoc_trimer PF08831.10 KII61612.1 - 0.017 15.1 0.7 0.062 13.3 0.1 2.3 2 0 0 2 2 1 0 Class II MHC-associated invariant chain trimerisation domain RIC3 PF15361.6 KII61612.1 - 0.018 15.4 0.4 0.018 15.4 0.4 1.7 2 0 0 2 2 1 0 Resistance to inhibitors of cholinesterase homologue 3 MAD PF05557.13 KII61612.1 - 0.023 13.1 19.6 0.035 12.5 8.3 1.7 1 1 1 2 2 2 0 Mitotic checkpoint protein ABC_tran_CTD PF16326.5 KII61612.1 - 0.049 13.9 11.8 1.3 9.3 4.2 3.0 1 1 2 3 3 3 0 ABC transporter C-terminal domain CCDC144C PF14915.6 KII61612.1 - 0.056 12.5 22.4 0.37 9.9 7.5 2.5 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region Jnk-SapK_ap_N PF09744.9 KII61612.1 - 0.067 13.4 22.4 0.19 12.0 7.9 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FliJ PF02050.16 KII61612.1 - 0.085 13.1 9.1 0.32 11.2 0.2 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein Pkinase_C PF00433.24 KII61612.1 - 0.094 13.4 0.5 0.39 11.5 0.5 2.1 1 1 0 1 1 1 0 Protein kinase C terminal domain DUF4407 PF14362.6 KII61612.1 - 0.1 11.9 5.0 0.16 11.3 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Golgin_A5 PF09787.9 KII61612.1 - 0.11 12.0 20.1 0.27 10.7 6.2 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF2703 PF10865.8 KII61612.1 - 0.13 12.5 9.5 0.14 12.3 2.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2703) HIP1_clath_bdg PF16515.5 KII61612.1 - 0.14 12.8 21.2 0.4 11.3 4.2 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cep57_CLD_2 PF14197.6 KII61612.1 - 0.15 12.2 20.3 0.19 11.8 9.2 3.4 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 Fib_alpha PF08702.10 KII61612.1 - 0.19 11.9 18.2 0.035 14.3 3.7 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DHR10 PF18595.1 KII61612.1 - 0.22 11.6 19.2 1.4 8.9 6.1 2.4 1 1 0 2 2 2 0 Designed helical repeat protein 10 domain DUF1664 PF07889.12 KII61612.1 - 0.23 11.5 14.3 0.6 10.1 4.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2203 PF09969.9 KII61612.1 - 0.26 12.0 7.6 0.52 11.0 1.2 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) BRE1 PF08647.11 KII61612.1 - 0.29 11.2 19.9 1.6 8.8 5.9 2.5 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase FlaC_arch PF05377.11 KII61612.1 - 0.52 10.7 17.3 2.9 8.4 1.7 4.2 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Atg14 PF10186.9 KII61612.1 - 0.55 9.3 19.2 0.033 13.3 6.9 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATG16 PF08614.11 KII61612.1 - 0.57 10.4 20.3 4.3 7.5 3.7 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 KII61612.1 - 0.58 10.2 21.4 0.61 10.2 4.7 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SHE3 PF17078.5 KII61612.1 - 0.66 9.7 21.2 0.76 9.5 9.5 2.2 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 DUF4140 PF13600.6 KII61612.1 - 0.75 10.3 9.3 3.8 8.0 1.7 3.0 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) H-kinase_dim PF02895.14 KII61612.1 - 1.5 9.2 8.4 1.1 9.7 1.8 2.7 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain UPF0242 PF06785.11 KII61612.1 - 1.7 8.7 19.7 11 6.1 19.4 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 KII61612.1 - 1.8 7.8 14.4 1.1 8.5 10.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) MetOD2 PF18548.1 KII61612.1 - 1.9 8.7 7.2 2.6 8.2 0.6 2.9 2 1 1 3 3 3 0 Metanogen output domain 2 IFT57 PF10498.9 KII61612.1 - 1.9 7.3 18.4 0.25 10.3 9.8 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 NPV_P10 PF05531.12 KII61612.1 - 2.2 8.8 12.5 15 6.1 2.6 3.3 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein YabA PF06156.13 KII61612.1 - 2.5 8.8 17.9 23 5.7 6.4 3.0 1 1 1 2 2 2 0 Initiation control protein YabA Cnn_1N PF07989.11 KII61612.1 - 2.5 8.3 16.1 4.6 7.5 9.1 3.4 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 SlyX PF04102.12 KII61612.1 - 2.9 8.6 11.5 12 6.6 0.2 3.0 1 1 2 3 3 3 0 SlyX YlqD PF11068.8 KII61612.1 - 3.7 7.9 13.5 14 6.0 11.2 2.5 1 1 2 3 3 3 0 YlqD protein SYCE1 PF15233.6 KII61612.1 - 3.9 7.5 20.1 0.48 10.5 6.8 2.4 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 DUF4349 PF14257.6 KII61612.1 - 4.9 6.5 10.5 0.82 9.1 2.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) CENP-Q PF13094.6 KII61612.1 - 5 7.3 17.4 18 5.5 2.9 2.6 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Csm1_N PF18504.1 KII61612.1 - 5.1 7.5 23.4 7.2 7.0 0.6 4.6 2 1 2 5 5 4 0 Csm1 N-terminal domain DUF641 PF04859.12 KII61612.1 - 5.5 7.3 16.3 4.2 7.7 5.2 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF16 PF01519.16 KII61612.1 - 6 7.4 15.4 31 5.1 9.3 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 SOGA PF11365.8 KII61612.1 - 6.1 8.0 15.1 0.61 11.3 1.2 3.1 1 1 2 3 3 2 0 Protein SOGA NAD_binding_6 PF08030.12 KII61612.1 - 6.3 6.9 12.0 1.2 9.3 1.7 2.4 1 1 1 2 2 2 0 Ferric reductase NAD binding domain Tropomyosin_1 PF12718.7 KII61612.1 - 6.4 6.9 20.4 22 5.2 5.3 2.3 1 1 1 2 2 2 0 Tropomyosin like Nup54 PF13874.6 KII61612.1 - 6.8 6.8 11.5 10 6.2 6.2 2.5 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 TPR_MLP1_2 PF07926.12 KII61612.1 - 7.5 6.6 22.6 3 7.9 3.5 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Exonuc_VII_L PF02601.15 KII61612.1 - 7.7 6.0 15.1 38 3.7 15.1 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit JIP_LZII PF16471.5 KII61612.1 - 9.3 6.5 19.6 9.1 6.5 4.9 3.3 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II CNH PF00780.22 KII61613.1 - 2.7e-21 76.4 0.1 7.5e-21 74.9 0.1 1.7 1 0 0 1 1 1 1 CNH domain TolA_bind_tri PF16331.5 KII61613.1 - 0.00032 20.7 0.9 0.00032 20.7 0.9 4.5 2 2 2 4 4 4 2 TolA binding protein trimerisation HMMR_N PF15905.5 KII61613.1 - 0.0072 15.8 4.4 0.0072 15.8 4.4 4.0 1 1 3 4 4 4 1 Hyaluronan mediated motility receptor N-terminal PHD PF00628.29 KII61613.1 - 0.016 15.1 3.2 0.016 15.1 3.2 2.5 2 0 0 2 2 2 0 PHD-finger Prok-RING_1 PF14446.6 KII61613.1 - 0.026 14.4 5.8 0.072 13.0 5.8 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_2 PF13831.6 KII61613.1 - 0.23 11.1 3.4 0.77 9.4 3.4 1.9 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 KII61613.1 - 0.38 10.7 13.7 0.085 12.7 9.7 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Smac_DIABLO PF09057.10 KII61613.1 - 5.5 6.3 13.2 5.3 6.3 4.4 2.5 2 0 0 2 2 2 0 Second Mitochondria-derived Activator of Caspases PSII_Pbs27 PF13326.6 KII61613.1 - 6.1 7.2 7.2 2.9 8.2 3.1 2.2 1 1 0 2 2 2 0 Photosystem II Pbs27 zf-RING_9 PF13901.6 KII61613.1 - 7 6.6 16.6 0.17 11.9 4.1 3.5 2 1 0 2 2 2 0 Putative zinc-RING and/or ribbon DUF1132 PF06575.12 KII61615.1 - 0.13 12.7 5.2 0.18 12.2 2.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1132) DUF4984 PF16372.5 KII61616.1 - 0.0085 16.0 1.3 0.016 15.2 1.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4984) Mistic PF11458.8 KII61616.1 - 0.11 12.5 3.3 1.2 9.2 0.1 2.9 2 2 0 2 2 2 0 Membrane-integrating protein Mistic DDE_3 PF13358.6 KII61617.1 - 1e-06 28.5 0.2 3.7e-05 23.5 0.1 2.2 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII61617.1 - 1.4e-05 24.7 0.0 2.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix B5 PF03484.15 KII61617.1 - 0.0029 17.9 0.0 0.0065 16.7 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase B5 domain CRIC_ras_sig PF10534.9 KII61617.1 - 0.019 15.1 0.0 0.045 13.9 0.0 1.7 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras HTH_Tnp_Tc3_2 PF01498.18 KII61617.1 - 0.021 15.0 0.0 0.041 14.1 0.0 1.5 1 1 0 1 1 1 0 Transposase HTH_Tnp_1_2 PF13022.6 KII61617.1 - 0.081 13.1 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase PAP2_C PF14360.6 KII61618.1 - 1.8e-21 76.4 12.3 2.4e-21 76.0 12.3 1.2 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PAP2 PF01569.21 KII61618.1 - 7.3e-05 22.6 4.0 8.9e-05 22.3 4.0 1.1 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 KII61618.1 - 0.016 14.9 4.9 0.022 14.4 4.9 1.3 1 0 0 1 1 1 0 PAP2 superfamily PyrI_C PF02748.15 KII61620.1 - 0.19 11.7 2.6 4.9 7.1 2.6 2.3 1 1 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DDE_Tnp_IS1595 PF12762.7 KII61621.1 - 1.9e-14 53.9 0.0 3.4e-14 53.1 0.0 1.4 2 0 0 2 2 2 1 ISXO2-like transposase domain zf-C2H2_7 PF15269.6 KII61622.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger MH1 PF03165.16 KII61623.1 - 5.4e-14 52.3 0.6 7.2e-14 51.8 0.6 1.2 1 0 0 1 1 1 1 MH1 domain DUF4371 PF14291.6 KII61625.1 - 0.0011 18.6 0.1 0.0012 18.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) UPF0147 PF03685.13 KII61625.1 - 0.0012 18.9 0.2 0.0046 17.0 0.2 1.8 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0147) Mac-1 PF09028.10 KII61625.1 - 0.031 13.3 0.2 0.035 13.2 0.2 1.1 1 0 0 1 1 1 0 Mac 1 PerB PF06590.11 KII61625.1 - 0.036 14.6 0.1 0.039 14.5 0.1 1.2 1 0 0 1 1 1 0 PerB protein P66_CC PF16563.5 KII61626.1 - 0.19 11.4 0.4 0.32 10.6 0.4 1.3 1 0 0 1 1 1 0 Coiled-coil and interaction region of P66A and P66B with MBD2 PGK PF00162.19 KII61627.1 - 1.1e-137 459.0 0.1 1.3e-137 458.8 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DDE_Tnp_IS1595 PF12762.7 KII61628.1 - 0.12 12.4 0.1 0.88 9.6 0.1 2.0 1 1 0 1 1 1 0 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII61630.1 - 5.1e-08 33.1 0.3 3.8e-07 30.2 0.1 1.9 1 1 1 2 2 2 1 ISXO2-like transposase domain FLYWCH PF04500.16 KII61632.1 - 5.1e-15 55.3 2.6 5.1e-15 55.3 2.6 1.8 2 0 0 2 2 2 1 FLYWCH zinc finger domain MULE PF10551.9 KII61632.1 - 3.2e-14 53.1 0.1 3.8e-12 46.5 0.1 2.4 2 0 0 2 2 2 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.17 KII61632.1 - 0.095 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Transposase Zn_ribbon_recom PF13408.6 KII61632.1 - 0.48 11.0 5.5 1 9.9 5.5 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain RT_RNaseH PF17917.1 KII61633.1 - 2.3e-40 137.1 0.0 5.2e-40 136.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII61633.1 - 5.3e-36 122.7 0.0 1.3e-35 121.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII61633.1 - 1.6e-30 106.3 0.1 3.4e-30 105.2 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII61633.1 - 1.4e-26 93.0 0.0 2.9e-26 92.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61633.1 - 1.9e-17 63.1 5.2 5.2e-17 61.7 2.5 2.8 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII61633.1 - 2.4e-06 28.0 0.0 5.8e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 KII61633.1 - 5.6e-06 26.2 0.5 1.2e-05 25.1 0.5 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII61633.1 - 2.1e-05 24.3 0.0 7.9e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.23 KII61633.1 - 0.00014 21.8 8.9 0.078 13.1 1.1 3.0 2 0 0 2 2 2 2 Zinc knuckle zf-H2C2 PF09337.10 KII61633.1 - 0.00097 19.3 0.0 0.0075 16.5 0.0 2.5 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII61633.1 - 0.0023 17.7 0.0 0.0072 16.1 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII61633.1 - 0.015 15.3 0.0 0.047 13.8 0.0 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Asp_protease_2 PF13650.6 KII61633.1 - 0.02 15.5 0.0 0.049 14.3 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII61633.1 - 0.069 13.5 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_2 PF13696.6 KII61633.1 - 0.2 11.5 11.8 1.5 8.7 4.6 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII61633.1 - 0.23 11.2 6.8 1.4 8.7 0.7 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 KII61633.1 - 0.28 11.1 13.7 0.23 11.3 2.4 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 KII61633.1 - 0.38 10.8 13.5 53 3.9 13.5 2.7 1 1 0 1 1 1 0 Zinc knuckle Cluap1 PF10234.9 KII61634.1 - 0.013 14.9 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 PPP1R26_N PF15740.5 KII61635.1 - 0.02 13.6 0.0 0.02 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 26 N-terminus RVT_1 PF00078.27 KII61636.1 - 1.8e-25 89.8 0.0 2.6e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII61636.1 - 9.6e-16 57.7 0.0 2e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61636.1 - 3.5e-06 27.2 0.0 8.1e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Asp_protease_2 PF13650.6 KII61636.1 - 0.053 14.2 0.0 0.096 13.3 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 KII61636.1 - 0.075 13.6 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RT_RNaseH_2 PF17919.1 KII61639.1 - 0.013 15.5 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Serpin PF00079.20 KII61640.1 - 4.4e-21 75.6 1.5 6.4e-17 61.9 0.0 2.0 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) Serpin PF00079.20 KII61641.1 - 3.3e-47 161.6 2.0 4e-47 161.3 2.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_Tnp_IS1595 PF12762.7 KII61643.1 - 8.2e-11 42.1 0.0 1.1e-10 41.7 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Wx5_PLAF3D7 PF09688.10 KII61644.1 - 0.003 17.6 0.2 0.0081 16.2 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (Wx5_PLAF3D7) ACP_PD PF04336.12 KII61644.1 - 0.0042 17.5 0.3 0.67 10.4 0.1 2.9 2 1 1 3 3 3 2 Acyl carrier protein phosphodiesterase OATP PF03137.20 KII61645.1 - 5e-87 292.4 35.4 3.8e-86 289.6 35.4 1.9 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KII61645.1 - 2.2e-18 66.3 33.7 9.2e-17 61.0 28.7 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KII61645.1 - 5.2e-09 35.4 0.4 7.6e-05 21.7 0.0 3.6 1 1 2 3 3 3 3 MFS_1 like family Kazal_2 PF07648.15 KII61645.1 - 0.016 15.3 6.8 0.04 14.1 6.8 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KII61645.1 - 0.16 12.0 2.3 0.4 10.7 2.3 1.6 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DnaB_C PF03796.15 KII61650.1 - 0.024 14.0 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Sec23_trunk PF04811.15 KII61651.1 - 7.1e-34 117.5 0.0 9.9e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 KII61651.1 - 2e-09 37.3 2.0 2e-09 37.3 2.0 2.8 3 0 0 3 3 3 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KII61652.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Gelsolin repeat Lactamase_B_6 PF16661.5 KII61653.1 - 3.3e-43 147.4 0.0 6.3e-43 146.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 KII61653.1 - 6.8e-19 68.7 0.1 3.2e-17 63.2 0.1 2.4 1 1 1 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 KII61653.1 - 2.7e-09 37.3 0.0 2.6e-08 34.1 0.0 2.6 3 0 0 3 3 3 1 Beta-Casp domain RMMBL PF07521.12 KII61653.1 - 5.4e-05 23.0 0.0 0.00013 21.8 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain BetaGal_dom4_5 PF13364.6 KII61653.1 - 0.1 13.1 0.0 0.31 11.6 0.0 1.8 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain DDE_Tnp_IS1595 PF12762.7 KII61654.1 - 2.3e-09 37.5 0.0 2.8e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain RRM_1 PF00076.22 KII61655.1 - 1.5e-20 72.8 0.0 4.7e-13 48.8 0.0 3.7 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC PF07744.13 KII61655.1 - 1.2e-15 57.7 0.1 2.6e-15 56.7 0.1 1.6 1 0 0 1 1 1 1 SPOC domain Nup35_RRM_2 PF14605.6 KII61655.1 - 0.037 14.0 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KII61655.1 - 0.075 13.1 0.0 6 7.0 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif DUF1356 PF07092.12 KII61655.1 - 0.098 11.9 0.3 0.18 11.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) RRM_7 PF16367.5 KII61655.1 - 0.16 12.1 0.0 36 4.6 0.0 3.0 2 1 1 3 3 3 0 RNA recognition motif Cullin PF00888.22 KII61656.1 - 2.4e-05 23.2 0.5 3.8e-05 22.5 0.3 1.5 1 1 1 2 2 2 1 Cullin family PBECR5 PF18814.1 KII61659.1 - 0.21 11.5 5.2 0.3 11.0 5.2 1.1 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 SOBP PF15279.6 KII61659.1 - 0.79 10.3 10.1 1.1 9.8 10.1 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein DUF778 PF05608.12 KII61659.1 - 1.2 9.5 6.8 2.2 8.6 6.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF778) TFIIA PF03153.13 KII61659.1 - 3.1 7.7 29.2 4 7.3 29.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 KII61659.1 - 3.4 4.7 12.4 4 4.4 12.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Pro_isomerase PF00160.21 KII61660.1 - 1.9e-36 125.7 0.1 3.4e-36 124.9 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Vfa1 PF08432.10 KII61660.1 - 0.0059 17.0 0.1 0.0059 17.0 0.1 1.6 2 0 0 2 2 2 1 AAA-ATPase Vps4-associated protein 1 La PF05383.17 KII61663.1 - 0.0011 19.0 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 La domain Mito_carr PF00153.27 KII61667.1 - 7e-47 157.3 1.2 1.4e-19 69.8 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KII61667.1 - 0.039 13.1 0.0 0.089 11.9 0.0 1.6 1 0 0 1 1 1 0 Gammaproteobacterial serine protease Antimicrobial20 PF08256.11 KII61667.1 - 0.041 14.4 0.8 0.35 11.5 0.0 3.0 3 0 0 3 3 3 0 Aurein-like antibiotic peptide DDE_3 PF13358.6 KII61671.1 - 0.00047 19.9 0.4 0.0012 18.6 0.3 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease DUF3403 PF11883.8 KII61671.1 - 0.37 11.0 2.1 1.3 9.2 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3403) AF0941-like PF14591.6 KII61672.1 - 0.044 14.3 0.7 0.078 13.5 0.7 1.4 1 0 0 1 1 1 0 AF0941-like Fe_dep_repr_C PF02742.15 KII61672.1 - 0.066 13.3 0.2 0.13 12.3 0.2 1.5 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain DUF3328 PF11807.8 KII61675.1 - 0.13 12.1 0.3 0.21 11.3 0.2 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3328) Sortilin-Vps10 PF15902.5 KII61676.1 - 3.4e-10 39.3 1.7 7.7e-10 38.1 1.7 1.5 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII61676.1 - 8.1e-09 36.0 0.8 1.7e-08 35.0 0.8 1.6 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII61676.1 - 0.0015 18.3 4.9 1.4 9.2 0.0 4.1 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF3276 PF11680.8 KII61676.1 - 0.15 12.2 3.2 0.38 10.9 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3276) Serpin PF00079.20 KII61677.1 - 2.2e-48 165.5 1.7 2.4e-48 165.3 1.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) TMEM72 PF16054.5 KII61677.1 - 0.0036 17.0 0.0 0.0063 16.2 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein family 72 Serpin PF00079.20 KII61678.1 - 3.5e-41 141.8 0.5 2.4e-40 139.0 0.5 1.9 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Septin PF00735.18 KII61679.1 - 3.7e-56 190.5 0.1 4.3e-56 190.3 0.1 1.0 1 0 0 1 1 1 1 Septin Serpin PF00079.20 KII61680.1 - 2.1e-13 50.4 0.4 2.7e-13 50.0 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII61681.1 - 3.5e-40 138.5 3.7 4.2e-40 138.2 3.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII61682.1 - 4e-18 65.9 3.0 4.4e-18 65.7 3.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII61684.1 - 2.8e-36 125.6 0.0 3.4e-36 125.4 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) UQ_con PF00179.26 KII61687.1 - 5.3e-17 61.8 0.6 1e-15 57.6 0.6 2.0 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF2990 PF11693.8 KII61687.1 - 0.085 13.0 0.1 0.31 11.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) DDE_3 PF13358.6 KII61688.1 - 1.9e-05 24.5 0.0 3.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Ala_racemase_N PF01168.20 KII61688.1 - 0.0012 18.5 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain zinc_ribbon_10 PF10058.9 KII61688.1 - 0.011 15.4 1.8 12 5.7 0.2 3.4 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein FBD PF08387.10 KII61688.1 - 0.029 14.2 0.0 0.098 12.6 0.0 1.9 1 0 0 1 1 1 0 FBD PDDEXK_7 PF04411.12 KII61688.1 - 0.14 12.2 2.0 0.25 11.3 0.7 1.7 1 1 0 2 2 2 0 PD-(D/E)XK nuclease superfamily SIP1 PF04938.12 KII61689.1 - 0.016 15.0 0.1 0.016 14.9 0.1 1.2 1 0 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) Myotub-related PF06602.14 KII61690.1 - 0.0029 16.6 0.1 0.0045 16.0 0.1 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain HTH_33 PF13592.6 KII61693.1 - 0.00014 21.4 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix MarR_2 PF12802.7 KII61693.1 - 0.0031 17.4 0.1 0.74 9.8 0.0 2.5 2 0 0 2 2 2 1 MarR family HTH_23 PF13384.6 KII61693.1 - 0.0035 17.1 0.0 0.2 11.5 0.0 3.0 3 0 0 3 3 3 1 Homeodomain-like domain PAX PF00292.18 KII61693.1 - 0.0061 16.5 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 'Paired box' domain HTH_24 PF13412.6 KII61693.1 - 0.013 15.0 0.0 0.2 11.2 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_29 PF13551.6 KII61693.1 - 0.014 15.4 0.0 2.8 8.0 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn helix TrmB PF01978.19 KII61693.1 - 0.018 14.9 0.0 3 7.8 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_32 PF13565.6 KII61693.1 - 0.031 14.9 0.0 0.14 12.8 0.0 2.2 2 2 1 3 3 3 0 Homeodomain-like domain DUF4817 PF16087.5 KII61693.1 - 0.038 13.8 1.0 9.5 6.1 0.2 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) Band_7 PF01145.25 KII61694.1 - 1.3e-07 31.8 0.1 1.5e-07 31.6 0.1 1.0 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF1191 PF06697.12 KII61694.1 - 0.13 12.1 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) M16C_assoc PF08367.11 KII61695.1 - 0.12 11.5 1.1 0.18 10.9 0.1 1.7 2 0 0 2 2 2 0 Peptidase M16C associated Mesothelin PF06060.12 KII61698.1 - 0.06 11.5 0.0 0.078 11.2 0.0 1.1 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Proteasome PF00227.26 KII61699.1 - 1.1e-33 116.4 0.0 1.4e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit MMACHC PF16690.5 KII61699.1 - 0.087 12.5 0.1 2.1 7.9 0.0 2.1 1 1 1 2 2 2 0 Methylmalonic aciduria and homocystinuria type C family ScsC_N PF18312.1 KII61699.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain ATP-synt_ab PF00006.25 KII61700.1 - 2.1e-62 210.6 0.1 2.8e-62 210.2 0.1 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KII61700.1 - 2.3e-12 47.3 0.2 4.7e-12 46.2 0.2 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Rtf2 PF04641.12 KII61700.1 - 0.15 11.4 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger PAS_9 PF13426.7 KII61701.1 - 0.00042 20.5 0.1 0.00072 19.8 0.1 1.4 1 1 0 1 1 1 1 PAS domain PAS PF00989.25 KII61701.1 - 0.0013 18.7 0.0 0.0043 17.0 0.0 1.8 1 1 0 1 1 1 1 PAS fold Acetyltransf_CG PF14542.6 KII61702.1 - 0.61 10.2 3.1 0.5 10.5 0.4 2.1 3 0 0 3 3 3 0 GCN5-related N-acetyl-transferase Rubredoxin_2 PF18073.1 KII61702.1 - 5.5 6.8 8.6 1.4 8.7 1.1 2.6 2 0 0 2 2 2 0 Rubredoxin metal binding domain Myosin_tail_1 PF01576.19 KII61703.1 - 0.061 11.1 1.1 0.092 10.5 1.1 1.2 1 0 0 1 1 1 0 Myosin tail NPV_P10 PF05531.12 KII61703.1 - 0.097 13.1 1.6 8.5 6.9 0.0 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TetR_C_2 PF08361.11 KII61704.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 MAATS-type transcriptional repressor, C-terminal region XRN1_D1 PF18332.1 KII61704.1 - 0.25 11.1 2.0 0.52 10.1 0.7 2.2 2 1 0 2 2 2 0 Exoribonuclease Xrn1 D1 domain EF-hand_7 PF13499.6 KII61704.1 - 0.65 10.5 3.2 1 9.9 1.5 2.3 1 1 1 2 2 2 0 EF-hand domain pair 2OG-FeII_Oxy_3 PF13640.6 KII61705.1 - 5.1e-09 36.9 0.0 8.5e-09 36.2 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KII61705.1 - 0.14 12.6 0.0 0.22 12.0 0.0 1.4 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DDE_3 PF13358.6 KII61706.1 - 4.5e-13 49.2 0.0 7.1e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease RDD PF06271.12 KII61708.1 - 2.1e-05 24.8 9.4 5.4e-05 23.4 9.4 1.7 1 1 0 1 1 1 1 RDD family DDE_3 PF13358.6 KII61709.1 - 0.00053 19.8 0.0 0.00079 19.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease MCM PF00493.23 KII61711.1 - 0.089 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 MCM P-loop domain MULE PF10551.9 KII61714.1 - 0.0073 16.7 0.1 0.052 14.0 0.0 2.1 2 0 0 2 2 2 1 MULE transposase domain Colipase PF01114.18 KII61715.1 - 0.22 11.2 1.5 0.22 11.2 0.1 1.7 2 0 0 2 2 2 0 Colipase, N-terminal domain DEAD PF00270.29 KII61717.1 - 1.7e-48 164.7 0.0 3.1e-48 163.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII61717.1 - 1e-30 106.4 0.5 2e-29 102.1 0.2 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KII61717.1 - 2.9e-07 30.0 0.1 4.5e-07 29.3 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 KII61717.1 - 0.001 19.1 0.0 0.0037 17.3 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 KII61718.1 - 1.9e-58 197.9 0.1 3.5e-58 197.0 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KII61718.1 - 6.6e-19 68.3 0.0 2.2e-18 66.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 KII61718.1 - 4.5e-17 61.7 3.7 2e-09 37.2 0.3 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 KII61718.1 - 5.8e-07 29.7 0.0 2.2e-06 27.8 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KII61718.1 - 2.2e-06 27.1 0.1 1.1e-05 24.8 0.1 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 KII61718.1 - 0.00096 19.0 0.0 0.0023 17.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-bind_7 PF15963.5 KII61718.1 - 0.019 14.9 0.2 0.066 13.1 0.2 1.9 1 0 0 1 1 1 0 Myb DNA-binding like DUF5344 PF17279.2 KII61718.1 - 0.065 13.8 2.9 0.34 11.5 2.9 2.3 1 0 0 1 1 1 0 Family of unknown function (DUF5344) DNA_pol3_gamma3 PF12169.8 KII61718.1 - 0.27 11.2 3.2 0.64 9.9 3.2 1.6 1 0 0 1 1 1 0 DNA polymerase III subunits gamma and tau domain III FXMRP1_C_core PF12235.8 KII61718.1 - 8.6 7.0 11.6 0.17 12.5 1.6 2.7 3 0 0 3 3 3 0 Fragile X-related 1 protein core C terminal DDE_3 PF13358.6 KII61720.1 - 2.7e-18 66.1 0.0 3.1e-18 65.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Fer4_12 PF13353.6 KII61720.1 - 0.039 14.2 0.0 0.05 13.9 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S single cluster domain HTH_33 PF13592.6 KII61721.1 - 0.032 13.9 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Arg_repressor PF01316.21 KII61721.1 - 0.05 13.4 0.1 0.37 10.6 0.1 2.0 1 1 1 2 2 2 0 Arginine repressor, DNA binding domain HTH_Tnp_Tc3_2 PF01498.18 KII61721.1 - 0.067 13.4 0.1 0.095 13.0 0.1 1.3 1 0 0 1 1 1 0 Transposase Sortilin_C PF15901.5 KII61724.1 - 1.5e-05 25.4 0.5 2.3e-05 24.8 0.5 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Gag_p10 PF02337.17 KII61726.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Retroviral GAG p10 protein PDCD7 PF16021.5 KII61727.1 - 0.0026 16.9 6.5 0.0026 16.9 6.5 1.5 2 0 0 2 2 2 1 Programmed cell death protein 7 Sas10_Utp3 PF04000.15 KII61727.1 - 0.0064 17.1 0.1 0.04 14.5 0.0 2.3 1 1 1 2 2 2 1 Sas10/Utp3/C1D family Tim29 PF10171.9 KII61727.1 - 0.074 12.5 0.4 0.19 11.2 0.1 1.7 2 0 0 2 2 2 0 Translocase of the Inner Mitochondrial membrane 29 RhoGEF67_u2 PF16614.5 KII61727.1 - 1.4 9.1 6.3 0.77 9.9 2.2 2.6 2 1 1 3 3 3 0 Unstructured region two on RhoGEF 6 and 7 Acyltransferase PF01553.21 KII61728.1 - 1.8e-18 66.5 0.1 3.4e-18 65.6 0.1 1.4 1 0 0 1 1 1 1 Acyltransferase Citrate_synt PF00285.21 KII61730.1 - 9.3e-90 301.3 0.0 1.1e-89 301.0 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain MRP-S22 PF10245.9 KII61731.1 - 4.8e-44 150.9 0.2 7.4e-44 150.3 0.2 1.4 1 1 0 1 1 1 1 Mitochondrial 28S ribosomal protein S22 MFS_1 PF07690.16 KII61732.1 - 5.9e-10 38.6 17.8 7.5e-10 38.3 17.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily EptA_B_N PF08019.12 KII61732.1 - 0.0083 16.0 0.2 0.0083 16.0 0.2 2.6 3 2 0 3 3 3 1 Phosphoethanolamine transferase EptA/EptB DUF5345 PF17280.2 KII61732.1 - 5.9 6.9 5.9 6.3 6.9 0.0 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5345) dsrm PF00035.26 KII61734.1 - 1.2e-08 35.5 0.5 0.00059 20.5 0.1 2.3 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 KII61734.1 - 0.0052 17.0 0.6 1.7 8.9 0.6 2.9 2 1 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 Dicer_dimer PF03368.14 KII61734.1 - 0.37 11.0 1.8 7.9 6.7 0.1 2.5 2 2 0 2 2 2 0 Dicer dimerisation domain tRNA_bind PF01588.20 KII61736.1 - 6.7e-13 48.6 0.2 1.1e-12 47.9 0.2 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain TAF PF02969.17 KII61737.1 - 0.00017 21.7 0.1 0.00029 21.0 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-T_C PF15511.6 KII61737.1 - 0.00025 21.1 0.0 0.00033 20.7 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 KII61737.1 - 0.0029 17.8 0.0 0.0044 17.3 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KII61737.1 - 0.0055 17.1 0.1 0.0062 16.9 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 KII61737.1 - 0.042 13.9 0.0 0.05 13.7 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 KII61737.1 - 0.078 13.4 0.1 0.11 12.9 0.1 1.5 1 1 0 1 1 1 0 CENP-S protein RICTOR_M PF14666.6 KII61741.1 - 3.2e-12 46.1 1.4 1.2e-09 37.8 0.1 3.2 2 1 1 3 3 3 2 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 KII61741.1 - 1.1e-05 25.7 0.4 0.00023 21.6 0.0 2.6 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 KII61741.1 - 4e-05 23.8 0.4 0.00026 21.2 0.1 2.2 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 CLASP_N PF12348.8 KII61741.1 - 0.066 12.8 0.0 0.3 10.6 0.0 2.0 2 0 0 2 2 2 0 CLASP N terminal LnmK_N_HDF PF18238.1 KII61741.1 - 0.093 12.5 0.1 6.4 6.5 0.1 2.2 2 0 0 2 2 2 0 LnmK N-terminal Hot Dog Fold domain ParA PF10609.9 KII61743.1 - 2e-66 223.9 0.0 2.2e-66 223.8 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 KII61743.1 - 1.1e-12 48.2 0.1 6.4e-12 45.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 KII61743.1 - 3.2e-12 46.6 0.0 4e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 KII61743.1 - 1.9e-10 40.4 1.0 4.7e-07 29.3 0.2 3.0 2 1 1 3 3 3 2 Anion-transporting ATPase MipZ PF09140.11 KII61743.1 - 2.2e-08 33.7 0.0 3.7e-08 33.0 0.0 1.3 1 1 0 1 1 1 1 ATPase MipZ CLP1_P PF16575.5 KII61743.1 - 0.00036 20.4 0.3 0.00077 19.3 0.1 1.6 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Fer4_NifH PF00142.18 KII61743.1 - 0.00079 18.9 0.1 0.0016 18.0 0.1 1.5 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 KII61743.1 - 0.0014 18.3 0.2 0.017 14.8 0.1 2.2 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain MeaB PF03308.16 KII61743.1 - 0.003 16.6 0.1 0.0044 16.0 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_26 PF13500.6 KII61743.1 - 0.01 15.7 0.2 3.9 7.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 KII61743.1 - 0.03 14.2 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF1610 PF07754.11 KII61743.1 - 0.055 13.5 0.5 0.15 12.0 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) VirC1 PF07015.11 KII61743.1 - 0.074 12.3 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 VirC1 protein CBP_BcsQ PF06564.12 KII61743.1 - 0.13 11.7 0.0 1.2 8.5 0.1 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ KTI12 PF08433.10 KII61743.1 - 0.17 11.3 0.0 0.24 10.8 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 KII61743.1 - 0.47 10.2 1.2 1.9 8.2 0.3 2.2 2 1 0 2 2 2 0 AAA domain CBF PF03914.17 KII61744.1 - 6.8e-14 52.3 1.9 1.3e-13 51.4 0.3 2.2 1 1 1 2 2 2 1 CBF/Mak21 family SRP14 PF02290.15 KII61744.1 - 0.0027 18.0 2.2 0.006 16.9 2.2 1.5 1 0 0 1 1 1 1 Signal recognition particle 14kD protein Mrpl_C PF18502.1 KII61744.1 - 0.3 11.4 3.0 0.62 10.4 0.7 2.5 3 0 0 3 3 3 0 54S ribosomal protein L8 C-terminal domain DDE_3 PF13358.6 KII61745.1 - 0.06 13.1 0.0 0.093 12.5 0.0 1.3 1 1 0 1 1 1 0 DDE superfamily endonuclease AhpC-TSA PF00578.21 KII61746.1 - 2.8e-40 137.1 0.0 4.1e-40 136.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KII61746.1 - 7.5e-17 61.4 0.0 1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 KII61746.1 - 3.7e-10 39.5 0.0 6.4e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 KII61746.1 - 0.079 12.9 0.1 0.25 11.3 0.1 1.7 2 0 0 2 2 2 0 SCO1/SenC MFS_1 PF07690.16 KII61747.1 - 1.8e-09 37.0 47.5 4.3e-09 35.8 34.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Aldo_ket_red PF00248.21 KII61748.1 - 3.6e-24 85.5 0.0 5.3e-24 84.9 0.0 1.2 1 1 0 1 1 1 1 Aldo/keto reductase family Cation_efflux PF01545.21 KII61749.1 - 2.3e-40 138.5 9.7 3.3e-40 138.0 9.7 1.2 1 0 0 1 1 1 1 Cation efflux family DotA PF11388.8 KII61749.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Phagosome trafficking protein DotA HMG_box PF00505.19 KII61750.1 - 2.5e-12 47.0 0.4 2.5e-12 47.0 0.4 2.8 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KII61750.1 - 2.2e-11 44.1 0.3 2.2e-11 44.1 0.3 2.6 3 0 0 3 3 3 1 HMG-box domain DUF2362 PF10154.9 KII61750.1 - 0.0056 15.7 0.7 0.0076 15.2 0.7 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) Myb_DNA-bind_4 PF13837.6 KII61750.1 - 0.048 14.0 1.6 0.23 11.9 0.1 2.6 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain UCH PF00443.29 KII61752.1 - 2.3e-44 151.8 0.3 4.1e-44 151.0 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KII61752.1 - 1.2e-17 64.5 0.2 1.1e-16 61.3 0.2 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 KII61752.1 - 1.2e-10 41.2 2.6 1.7e-10 40.6 2.6 1.3 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 KII61753.1 - 8.1e-05 22.4 0.1 0.00016 21.5 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin-specific protease C-terminal AKAP7_NLS PF10469.9 KII61755.1 - 1e-38 133.3 0.2 1.1e-38 133.2 0.2 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 KII61755.1 - 5.6e-10 39.3 0.0 7e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily GSH-S_ATP PF02955.16 KII61755.1 - 0.0043 16.5 0.0 0.0064 15.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain HVSL PF09749.9 KII61755.1 - 0.058 12.9 0.1 0.071 12.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein UAA PF08449.11 KII61756.1 - 6.3e-88 294.9 25.8 7.8e-88 294.6 25.8 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KII61756.1 - 4.4e-05 23.7 10.5 4.4e-05 23.7 10.5 3.5 2 2 0 2 2 2 1 EamA-like transporter family TPT PF03151.16 KII61756.1 - 0.0061 16.0 15.4 0.035 13.5 15.4 2.2 1 1 0 1 1 1 1 Triose-phosphate Transporter family CK_II_beta PF01214.18 KII61757.1 - 3.9e-47 160.4 0.7 4.8e-47 160.1 0.7 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CK_II_beta PF01214.18 KII61758.1 - 3.4e-49 167.1 0.0 4.2e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit DDE_Tnp_IS1595 PF12762.7 KII61759.1 - 2.1e-06 27.8 0.0 4.6e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain RT_RNaseH_2 PF17919.1 KII61761.1 - 1.9e-36 124.1 0.1 4.2e-36 123.0 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61761.1 - 6.7e-34 116.3 0.0 1.8e-33 115.0 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII61761.1 - 6.4e-31 107.6 0.0 1.2e-30 106.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII61761.1 - 5.4e-21 75.0 0.0 5.4e-19 68.5 0.0 3.6 4 0 0 4 4 4 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61761.1 - 8.5e-21 73.8 0.1 1.9e-20 72.7 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII61761.1 - 1.1e-07 32.3 0.0 2.1e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.17 KII61761.1 - 7.3e-05 23.0 0.0 0.0011 19.2 0.0 2.6 2 0 0 2 2 2 1 Retrotransposon gag protein Asp_protease_2 PF13650.6 KII61761.1 - 7.7e-05 23.3 0.0 0.00017 22.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 KII61761.1 - 0.00085 19.1 0.0 0.0051 16.6 0.0 2.2 3 0 0 3 3 3 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII61761.1 - 0.0027 17.5 0.3 0.0053 16.6 0.3 1.4 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A17 PF05380.13 KII61761.1 - 0.0079 16.2 0.1 0.02 14.9 0.1 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase MLVIN_C PF18697.1 KII61761.1 - 0.029 14.4 0.0 0.093 12.8 0.0 1.9 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain zf-H2C2 PF09337.10 KII61761.1 - 0.052 13.8 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 H2C2 zinc finger zf-CCHC_5 PF14787.6 KII61761.1 - 0.072 12.8 1.5 0.16 11.7 1.5 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Peptidase_A3 PF02160.15 KII61761.1 - 0.086 12.3 3.0 0.042 13.3 0.5 1.7 2 0 0 2 2 2 0 Cauliflower mosaic virus peptidase (A3) TetR_C_25 PF17933.1 KII61761.1 - 0.13 12.6 0.0 4.9 7.5 0.0 2.8 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain zf-CCHC_4 PF14392.6 KII61761.1 - 0.2 11.4 1.3 0.61 9.9 1.3 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 KII61761.1 - 0.42 10.8 10.0 0.016 15.2 2.9 2.5 2 0 0 2 2 2 0 Zinc knuckle IU_nuc_hydro PF01156.19 KII61762.1 - 3.8e-37 128.5 0.1 4.5e-37 128.3 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase NPC1_N PF16414.5 KII61762.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Niemann-Pick C1 N terminus DDE_Tnp_IS1595 PF12762.7 KII61763.1 - 8.5e-09 35.6 0.0 1.1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain NPL4 PF05021.15 KII61767.1 - 4.3e-93 312.0 0.0 5.6e-93 311.7 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 KII61767.1 - 1.2e-37 129.3 1.9 1.2e-37 129.3 1.9 2.1 2 0 0 2 2 2 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 KII61767.1 - 0.00087 19.7 0.0 0.0021 18.5 0.0 1.6 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Vps36-NZF-N PF16988.5 KII61767.1 - 0.0026 17.1 2.6 0.0026 17.1 2.6 2.2 2 0 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain ESCRT-II PF05871.12 KII61768.1 - 0.00022 21.5 0.5 0.00028 21.2 0.5 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit eRF1_3 PF03465.15 KII61769.1 - 0.089 13.3 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 eRF1 domain 3 Sortilin_C PF15901.5 KII61771.1 - 5.9e-12 46.3 0.1 7.3e-12 46.0 0.1 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Motile_Sperm PF00635.26 KII61775.1 - 9.5e-15 54.4 1.8 1.6e-14 53.6 1.8 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF5001 PF16392.5 KII61775.1 - 0.0039 17.1 2.9 0.032 14.1 2.0 2.3 1 1 1 2 2 2 1 Ig-like domain fn3_6 PF17766.1 KII61775.1 - 0.0044 17.2 0.2 0.15 12.3 0.1 2.2 2 0 0 2 2 2 1 Fibronectin type-III domain CCSMST1 PF15013.6 KII61775.1 - 0.057 13.6 1.2 0.11 12.7 0.2 1.9 2 0 0 2 2 2 0 CCSMST1 family DDE_3 PF13358.6 KII61776.1 - 0.035 13.9 0.1 0.054 13.3 0.1 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease RT_RNaseH PF17917.1 KII61777.1 - 5.5e-35 119.8 0.0 1.2e-34 118.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII61777.1 - 7.7e-35 118.9 0.0 1.5e-34 118.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII61777.1 - 4.1e-21 75.4 0.0 9.6e-21 74.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 KII61777.1 - 2.1e-19 69.9 0.0 5.6e-19 68.5 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII61777.1 - 2.9e-18 65.7 1.6 2.9e-18 65.7 1.6 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII61777.1 - 0.00048 19.8 0.0 0.0015 18.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII61777.1 - 0.0013 18.9 0.1 0.0013 18.9 0.1 2.0 2 0 0 2 2 2 1 H2C2 zinc finger eIF-1a PF01176.19 KII61777.1 - 0.04 13.7 0.1 0.098 12.5 0.1 1.6 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 DUF5641 PF18701.1 KII61777.1 - 0.066 13.4 0.1 0.27 11.4 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5641) zf-CCHC PF00098.23 KII61778.1 - 0.084 13.0 13.4 0.1 12.7 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle Retrotrans_gag PF03732.17 KII61778.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein ANAPC10 PF03256.16 KII61780.1 - 3.5e-30 105.0 0.0 4.2e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Tetraspanin PF00335.20 KII61783.1 - 3.9e-15 56.2 15.1 5.1e-15 55.8 15.1 1.1 1 0 0 1 1 1 1 Tetraspanin family MLVIN_C PF18697.1 KII61784.1 - 0.0015 18.6 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DUF485 PF04341.12 KII61785.1 - 0.032 14.2 4.6 0.2 11.7 4.6 2.0 1 1 0 1 1 1 0 Protein of unknown function, DUF485 VID27_PH PF17747.1 KII61786.1 - 0.005 17.1 2.6 0.0082 16.4 2.2 1.6 1 1 0 1 1 1 1 VID27 PH-like domain Cupredoxin_1 PF13473.6 KII61787.1 - 0.019 15.1 0.1 0.042 14.0 0.1 1.5 1 0 0 1 1 1 0 Cupredoxin-like domain Retrotran_gag_2 PF14223.6 KII61788.1 - 0.0064 16.2 0.1 0.035 13.8 0.0 1.9 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type Mtp PF03821.16 KII61789.1 - 0.024 14.2 0.2 0.042 13.5 0.1 1.4 1 1 0 1 1 1 0 Golgi 4-transmembrane spanning transporter Anoct_dimer PF16178.5 KII61789.1 - 0.041 13.6 1.3 0.063 13.0 1.3 1.4 1 1 0 1 1 1 0 Dimerisation domain of Ca+-activated chloride-channel, anoctamin L_protein_N PF15518.6 KII61790.1 - 0.04 13.7 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 L protein N-terminus DUF4803 PF16061.5 KII61790.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4803) zf-NADH-PPase PF09297.11 KII61792.1 - 4.6 7.0 9.4 45 3.8 1.8 4.1 4 1 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain RVT_1 PF00078.27 KII61794.1 - 0.054 13.0 0.2 0.09 12.3 0.2 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 KII61794.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) UvrD_C PF13361.6 KII61796.1 - 4.3e-34 118.4 0.2 5.1e-34 118.2 0.2 1.1 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 KII61796.1 - 7.1e-11 41.8 0.0 5.2e-10 39.0 0.0 2.3 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Exonuc_V_gamma PF04257.14 KII61796.1 - 0.011 14.0 0.0 0.014 13.6 0.0 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit Viral_helicase1 PF01443.18 KII61796.1 - 0.013 15.3 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase EAL PF00563.20 KII61797.1 - 5.8e-72 242.1 0.3 9.1e-72 241.4 0.3 1.3 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 KII61797.1 - 7.1e-42 142.9 0.2 1.3e-41 142.0 0.2 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GGDEF_2 PF17853.1 KII61797.1 - 0.0011 19.2 0.3 0.0037 17.5 0.0 2.1 3 0 0 3 3 3 1 GGDEF-like domain Wzy_C PF04932.15 KII61798.1 - 3.3e-17 62.5 0.7 3.3e-17 62.5 0.7 3.3 2 2 1 3 3 3 1 O-Antigen ligase O-antigen_lig PF13425.6 KII61798.1 - 0.04 12.7 0.1 0.086 11.6 0.0 1.6 1 1 0 1 1 1 0 O-antigen ligase like membrane protein Glycos_transf_2 PF00535.26 KII61799.1 - 7e-17 61.7 0.0 1.4e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 KII61799.1 - 1.1e-06 28.7 0.0 1.6e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KII61799.1 - 5.3e-06 26.5 0.0 7.3e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KII61799.1 - 0.00076 19.1 0.1 0.0013 18.3 0.1 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase zf-U11-48K PF05253.12 KII61800.1 - 2.9e-09 36.6 6.0 1.2e-06 28.3 0.4 3.0 3 0 0 3 3 3 2 U11-48K-like CHHC zinc finger dsrm PF00035.26 KII61800.1 - 0.046 14.4 0.0 0.085 13.6 0.0 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding motif Integrase_H2C2 PF17921.1 KII61802.1 - 1.8e-11 44.0 0.1 3.9e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 KII61803.1 - 9.1e-10 38.5 0.0 3.5e-09 36.6 0.0 1.8 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61803.1 - 1.9e-08 34.5 0.0 3.8e-08 33.6 0.0 1.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase PIF1 PF05970.14 KII61807.1 - 2.1e-26 93.0 0.4 2.3e-26 92.9 0.4 1.1 1 0 0 1 1 1 1 PIF1-like helicase RPN13_C PF16550.5 KII61807.1 - 0.094 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 UCH-binding domain DUF5305 PF17231.2 KII61808.1 - 4.8e-05 22.9 11.4 6.1e-05 22.5 11.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Stevor PF17410.2 KII61808.1 - 0.00027 20.6 2.5 0.00034 20.2 2.5 1.1 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame RIFIN PF02009.16 KII61808.1 - 0.00079 19.4 9.4 0.00099 19.1 9.4 1.1 1 0 0 1 1 1 1 Rifin DUF4448 PF14610.6 KII61808.1 - 0.0046 16.8 1.3 0.007 16.2 1.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Orf78 PF06024.12 KII61808.1 - 0.0064 16.8 0.7 0.012 15.9 0.4 1.6 1 1 0 1 1 1 1 Orf78 (ac78) DUF5527 PF17665.1 KII61808.1 - 0.018 14.5 2.3 0.018 14.5 2.3 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5527) DUF2370 PF10176.9 KII61808.1 - 0.035 13.7 0.1 0.044 13.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Vma12 PF11712.8 KII61808.1 - 0.038 14.1 1.3 0.053 13.6 1.3 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF3464 PF11947.8 KII61808.1 - 0.1 12.3 0.9 0.15 11.8 0.9 1.4 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 PAP1 PF08601.10 KII61808.1 - 0.11 12.3 7.2 0.12 12.0 7.2 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 Endomucin PF07010.12 KII61808.1 - 0.15 12.0 22.5 0.2 11.6 22.5 1.1 1 0 0 1 1 1 0 Endomucin AMA-1 PF02430.15 KII61808.1 - 0.18 10.7 0.9 0.23 10.4 0.9 1.1 1 0 0 1 1 1 0 Apical membrane antigen 1 CrgA PF06781.12 KII61808.1 - 0.57 10.3 3.4 0.31 11.1 0.8 1.9 1 1 1 2 2 2 0 Cell division protein CrgA WD40 PF00400.32 KII61811.1 - 4.7e-07 30.4 9.1 1.3e-05 25.8 0.3 5.4 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII61811.1 - 0.0073 16.6 0.0 0.11 12.8 0.0 2.5 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain TFIID_30kDa PF03540.13 KII61812.1 - 3.7e-16 58.8 0.0 7.4e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Ribosomal_60s PF00428.19 KII61812.1 - 0.073 13.7 0.1 0.33 11.6 0.0 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein Lactamase_B PF00753.27 KII61813.1 - 3.5e-07 30.4 0.0 3.7e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KII61813.1 - 4.5e-05 23.1 0.0 4.9e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PDEase_II PF02112.15 KII61813.1 - 0.013 14.6 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II DUF5617 PF18493.1 KII61813.1 - 0.015 15.4 0.4 0.024 14.7 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) DNA_ligase_ZBD PF03119.16 KII61814.1 - 0.1 12.7 0.9 0.33 11.0 0.3 2.1 1 1 1 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Utp12 PF04003.12 KII61815.1 - 0.042 14.2 0.7 0.31 11.4 0.1 2.1 1 1 1 2 2 2 0 Dip2/Utp12 Family Hexokinase_2 PF03727.16 KII61817.1 - 1.8e-30 106.2 0.2 2.6e-30 105.6 0.2 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII61817.1 - 2.9e-26 92.6 0.0 4.2e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 KII61818.1 - 2.5e-34 118.8 0.3 3.1e-34 118.5 0.3 1.1 1 0 0 1 1 1 1 Hexokinase DDE_3 PF13358.6 KII61821.1 - 1.8e-08 34.3 0.0 3.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_IS630 PF01710.16 KII61821.1 - 0.00014 21.8 0.2 0.00026 21.0 0.2 1.4 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 KII61821.1 - 0.00058 19.6 0.0 0.0073 16.1 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 KII61821.1 - 0.00068 19.2 0.0 0.0022 17.6 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix PAX PF00292.18 KII61821.1 - 0.0053 16.7 0.0 0.012 15.5 0.0 1.6 2 0 0 2 2 2 1 'Paired box' domain HTH_Crp_2 PF13545.6 KII61821.1 - 0.0098 15.8 0.0 0.54 10.3 0.0 2.3 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_28 PF13518.6 KII61821.1 - 0.021 14.9 0.1 0.3 11.3 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII61821.1 - 0.027 14.7 1.1 0.069 13.4 0.7 1.9 2 0 0 2 2 2 0 Transposase Lactamase_B PF00753.27 KII61823.1 - 2.7e-10 40.6 0.1 3.2e-10 40.4 0.1 1.0 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KII61823.1 - 0.0085 15.6 0.0 0.01 15.4 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CBAH PF02275.18 KII61823.1 - 0.042 13.5 0.0 0.042 13.5 0.0 1.1 1 0 0 1 1 1 0 Linear amide C-N hydrolases, choloylglycine hydrolase family DUF5449 PF17528.2 KII61823.1 - 0.058 13.2 0.0 0.063 13.0 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5449) Utp12 PF04003.12 KII61824.1 - 1e-11 45.1 0.7 1.4e-11 44.6 0.7 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Ldl_recept_a PF00057.18 KII61830.1 - 1.2e-44 150.2 125.4 1.5e-10 41.1 8.3 7.8 7 0 0 7 7 7 7 Low-density lipoprotein receptor domain class A E1_DerP2_DerF2 PF02221.15 KII61834.1 - 3.9e-06 27.3 0.5 5.2e-06 26.9 0.5 1.1 1 0 0 1 1 1 1 ML domain Integrase_H2C2 PF17921.1 KII61836.1 - 0.0003 20.8 0.1 0.00044 20.3 0.1 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII61838.1 - 8.7e-19 67.9 0.0 1.1e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII61838.1 - 0.094 12.5 0.0 0.21 11.4 0.0 1.7 1 1 0 1 1 1 0 Integrase core domain Tetraspanin PF00335.20 KII61840.1 - 3.1e-05 23.8 5.9 3.6e-05 23.6 5.9 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF4134 PF13572.6 KII61840.1 - 0.0029 17.9 2.2 0.0029 17.9 2.2 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4134) TauE PF01925.19 KII61840.1 - 0.0065 16.1 5.6 0.0085 15.8 5.6 1.3 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE DUF4173 PF13777.6 KII61840.1 - 0.039 13.4 4.5 0.052 13.0 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) Arteri_Gl PF00951.18 KII61840.1 - 1.5 8.6 6.9 0.49 10.2 4.1 1.5 1 1 1 2 2 2 0 Arterivirus GL envelope glycoprotein GRIP PF01465.20 KII61845.1 - 0.013 15.4 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 GRIP domain RVT_1 PF00078.27 KII61846.1 - 2.8e-05 23.7 0.0 4.9e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_3 PF13917.6 KII61846.1 - 0.00038 20.4 12.6 0.023 14.7 2.0 2.6 1 1 1 2 2 2 2 Zinc knuckle gag-asp_proteas PF13975.6 KII61846.1 - 0.00057 20.4 0.0 0.0013 19.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Peptidase_A2E PF12382.8 KII61846.1 - 0.0082 16.2 0.3 0.015 15.3 0.3 1.4 1 0 0 1 1 1 1 Retrotransposon peptidase Retrotran_gag_2 PF14223.6 KII61846.1 - 0.018 14.7 0.1 0.12 12.0 0.1 2.1 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type Asp_protease_2 PF13650.6 KII61846.1 - 0.061 14.0 0.0 0.13 13.0 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 KII61846.1 - 0.073 13.2 13.9 1.4 9.1 5.9 2.7 2 0 0 2 2 2 0 Zinc knuckle RVP PF00077.20 KII61846.1 - 0.083 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease RT_RNaseH PF17917.1 KII61847.1 - 1.7e-33 115.0 0.0 3.8e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII61847.1 - 1.2e-31 108.7 0.0 2.3e-31 107.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII61847.1 - 1.1e-20 74.0 0.0 3.7e-20 72.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61847.1 - 6.3e-15 55.0 0.0 1.3e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Clusterin PF01093.17 KII61848.1 - 0.17 10.9 0.1 0.19 10.8 0.1 1.0 1 0 0 1 1 1 0 Clusterin Serpin PF00079.20 KII61849.1 - 1.1e-35 123.6 1.4 1.6e-35 123.2 1.4 1.2 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.26 KII61852.1 - 2e-22 79.6 0.0 3.2e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61852.1 - 6.1e-08 32.7 2.9 6.1e-08 32.7 2.9 2.4 3 0 0 3 3 3 1 Integrase zinc binding domain rve_3 PF13683.6 KII61852.1 - 0.00019 21.1 0.0 0.00043 20.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Agenet PF05641.12 KII61852.1 - 0.067 13.7 0.4 0.75 10.3 0.0 2.3 2 0 0 2 2 2 0 Agenet domain Myosin_N PF02736.19 KII61852.1 - 0.14 12.0 0.0 0.42 10.5 0.0 1.9 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Fig1 PF12351.8 KII61854.1 - 0.037 14.0 0.5 0.044 13.7 0.5 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Peptidase_S9 PF00326.21 KII61856.1 - 6.1e-20 71.6 0.0 9e-20 71.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KII61856.1 - 4.5e-06 26.1 0.0 0.039 13.2 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KII61856.1 - 5.9e-06 26.1 0.0 0.0037 17.0 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 KII61856.1 - 4.6e-05 23.1 0.0 9.3e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 KII61856.1 - 0.00054 19.7 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S28 PF05577.12 KII61856.1 - 0.0091 14.8 0.0 0.025 13.4 0.0 1.7 2 0 0 2 2 2 1 Serine carboxypeptidase S28 Tannase PF07519.11 KII61856.1 - 0.027 13.4 0.0 0.06 12.3 0.0 1.5 1 0 0 1 1 1 0 Tannase and feruloyl esterase ANAPC_CDC26 PF10471.9 KII61856.1 - 0.062 14.1 0.2 0.13 13.1 0.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Abhydrolase_2 PF02230.16 KII61856.1 - 0.093 12.5 0.0 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase ArsC PF03960.15 KII61858.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.4 1 1 0 1 1 1 0 ArsC family AT_hook PF02178.19 KII61859.1 - 1.4 9.0 9.6 0.15 12.1 1.4 2.8 2 0 0 2 2 2 0 AT hook motif Tudor_3 PF18115.1 KII61860.1 - 0.02 14.8 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain Agenet PF05641.12 KII61860.1 - 0.11 13.0 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Agenet domain PP_kinase_N PF13089.6 KII61862.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain 3H PF02829.14 KII61862.1 - 0.16 12.3 0.4 5.2 7.4 0.0 3.0 3 1 1 4 4 4 0 3H domain Peptidase_S9 PF00326.21 KII61866.1 - 4.6e-22 78.5 0.0 5.1e-19 68.6 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KII61866.1 - 2.6e-08 33.4 0.0 0.00035 19.9 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 KII61866.1 - 2.2e-05 24.1 0.0 3.8e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 KII61866.1 - 3.6e-05 23.5 0.3 0.0011 18.7 0.5 2.3 1 1 1 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.13 KII61866.1 - 0.0013 18.4 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 KII61866.1 - 0.007 16.0 0.0 3.2 7.3 0.0 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S28 PF05577.12 KII61866.1 - 0.015 14.1 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Serpin PF00079.20 KII61867.1 - 1.9e-46 159.1 3.4 2.4e-46 158.8 3.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RRM_1 PF00076.22 KII61869.1 - 6.5e-10 38.7 0.0 1.3e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CbiG_mid PF11761.8 KII61869.1 - 0.11 12.7 0.2 2.2 8.4 0.2 2.6 1 1 0 1 1 1 0 Cobalamin biosynthesis central region Cytomega_UL20A PF05984.12 KII61869.1 - 0.19 12.1 0.1 0.19 12.1 0.1 2.0 2 1 0 2 2 2 0 Cytomegalovirus UL20A protein FoP_duplication PF13865.6 KII61869.1 - 0.33 11.5 7.0 6.1 7.5 7.0 2.7 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Helicase_C PF00271.31 KII61872.1 - 4e-27 94.7 0.2 8.3e-26 90.5 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KII61872.1 - 1.6e-26 93.2 0.4 3.1e-26 92.2 0.4 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KII61872.1 - 1.5e-10 41.3 0.0 3.1e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 KII61872.1 - 0.0047 15.8 0.1 0.12 11.1 0.0 2.1 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 T4SS-DNA_transf PF02534.14 KII61872.1 - 0.025 13.4 0.0 0.042 12.7 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AAA_22 PF13401.6 KII61872.1 - 0.035 14.4 0.0 0.37 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 KII61872.1 - 0.048 12.7 0.0 0.074 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein SWI2_SNF2 PF18766.1 KII61872.1 - 0.055 13.1 0.0 0.09 12.4 0.0 1.3 1 0 0 1 1 1 0 SWI2/SNF2 ATPase DUF87 PF01935.17 KII61872.1 - 0.063 13.4 0.1 0.33 11.0 0.0 2.0 1 1 1 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 KII61872.1 - 0.098 12.2 0.0 0.99 8.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Pkinase PF00069.25 KII61873.1 - 1.6e-58 198.2 0.0 2.5e-58 197.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII61873.1 - 8.4e-32 110.5 0.0 1.3e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KII61873.1 - 0.036 13.4 0.0 0.11 11.8 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII61873.1 - 0.061 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Chorismate_synt PF01264.21 KII61873.1 - 0.14 10.9 0.2 0.21 10.3 0.2 1.2 1 0 0 1 1 1 0 Chorismate synthase P63C PF10546.9 KII61875.1 - 0.0066 17.0 0.4 0.02 15.5 0.1 1.8 2 0 0 2 2 2 1 P63C domain LRR_6 PF13516.6 KII61876.1 - 0.006 16.5 13.3 0.93 9.7 0.0 5.7 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KII61876.1 - 0.027 14.9 34.8 0.22 12.0 0.2 7.9 5 1 3 9 9 9 0 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KII61876.1 - 0.12 11.9 3.6 1.8 8.0 0.5 3.3 2 1 1 3 3 3 0 Leucine-rich repeat ACDC PF14733.6 KII61882.1 - 0.41 11.0 2.9 6.1 7.2 0.0 3.0 3 0 0 3 3 3 0 AP2-coincident C-terminal Sortilin_C PF15901.5 KII61883.1 - 2.2e-17 64.0 9.2 2.2e-17 64.0 9.2 3.2 3 0 0 3 3 3 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII61883.1 - 1e-08 34.5 1.1 1e-08 34.5 1.1 3.6 3 1 0 4 4 4 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII61883.1 - 0.00048 20.3 14.7 0.00048 20.3 14.7 4.9 4 1 1 5 5 5 2 Low-density lipoprotein receptor domain class A BNR PF02012.20 KII61883.1 - 0.41 10.8 9.5 1.3 9.3 0.4 4.3 4 0 0 4 4 4 0 BNR/Asp-box repeat Complex1_LYR_2 PF13233.6 KII61884.1 - 0.075 13.8 1.4 10 6.9 0.4 2.5 2 0 0 2 2 2 0 Complex1_LYR-like zf-CCHC PF00098.23 KII61885.1 - 0.00042 20.2 0.4 0.00062 19.7 0.4 1.3 1 0 0 1 1 1 1 Zinc knuckle HscB_4_cys PF18256.1 KII61885.1 - 0.06 13.2 0.9 0.13 12.1 0.9 1.5 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif RdRP_4 PF02123.16 KII61886.1 - 0.061 12.2 0.0 0.064 12.1 0.0 1.0 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase MULE PF10551.9 KII61887.1 - 6.3e-15 55.4 0.0 1.2e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.16 KII61887.1 - 2.3e-08 34.0 0.2 4.7e-08 33.0 0.2 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain RT_RNaseH PF17917.1 KII61888.1 - 7e-08 32.7 0.2 7e-08 32.7 0.2 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII61888.1 - 3.7e-05 23.7 0.0 7.2e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII61889.1 - 7.4e-08 32.6 0.0 1.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Ras PF00071.22 KII61893.1 - 3e-41 140.7 0.0 4.6e-41 140.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII61893.1 - 2.9e-16 59.8 0.0 5.1e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KII61893.1 - 9.1e-09 35.1 0.0 1.3e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 KII61893.1 - 5.1e-05 22.8 0.0 5.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII61893.1 - 0.014 14.7 0.1 0.04 13.3 0.1 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Cas_Cas4 PF01930.17 KII61893.1 - 0.021 14.9 0.6 0.034 14.2 0.4 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF83 AAA_24 PF13479.6 KII61893.1 - 0.31 10.7 1.8 1.7 8.3 0.6 2.3 2 1 0 2 2 2 0 AAA domain DDE_3 PF13358.6 KII61896.1 - 8.3e-12 45.1 0.0 1.2e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII61897.1 - 0.051 13.4 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Homeodomain-like domain RasGAP_C PF03836.15 KII61898.1 - 0.13 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 RasGAP C-terminus FixG_C PF11614.8 KII61900.1 - 0.091 13.0 0.6 0.12 12.6 0.6 1.3 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase AMPK1_CBM PF16561.5 KII61903.1 - 8.5e-21 74.0 0.0 1.5e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 KII61903.1 - 0.0091 16.3 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) MULE PF10551.9 KII61904.1 - 1.5e-11 44.6 0.0 2.9e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.18 KII61904.1 - 0.00038 19.4 0.4 0.00054 18.9 0.4 1.2 1 0 0 1 1 1 1 Transposase, Mutator family PPP4R2 PF09184.11 KII61906.1 - 0.036 13.7 0.5 0.045 13.3 0.5 1.1 1 0 0 1 1 1 0 PPP4R2 DUF4763 PF15960.5 KII61907.1 - 0.05 12.9 0.7 0.095 12.0 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) G_glu_transpept PF01019.21 KII61910.1 - 6.6e-116 388.1 0.0 8.3e-116 387.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase ESCRT-II PF05871.12 KII61910.1 - 0.19 12.0 0.5 2.9 8.1 0.0 2.5 2 0 0 2 2 2 0 ESCRT-II complex subunit Serpin PF00079.20 KII61911.1 - 2.4e-59 201.6 0.7 2.7e-59 201.4 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Arm PF00514.23 KII61912.1 - 1.5e-12 47.1 0.3 3.7e-06 26.8 0.1 2.6 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KII61912.1 - 3.2e-05 24.3 0.1 0.00018 21.9 0.1 2.2 2 1 1 3 3 3 1 HEAT-like repeat HEAT_2 PF13646.6 KII61912.1 - 0.00016 22.0 0.0 0.0031 17.9 0.0 2.2 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.22 KII61912.1 - 0.0017 18.4 0.2 1.3 9.5 0.1 3.2 3 0 0 3 3 3 2 HEAT repeat Cnd1 PF12717.7 KII61912.1 - 0.018 15.1 0.0 0.047 13.7 0.0 1.7 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 KII61913.1 - 3.9e-08 33.1 1.1 0.008 16.2 0.0 3.9 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat DUF3361 PF11841.8 KII61913.1 - 0.0018 18.3 2.7 0.34 10.9 0.2 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF3361) Wap1 PF16997.5 KII61913.1 - 0.0035 16.5 1.6 0.0045 16.2 1.3 1.3 1 1 0 1 1 1 1 Wap1 domain Arm PF00514.23 KII61914.1 - 1.4e-12 47.2 0.3 0.00017 21.5 0.1 5.3 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KII61914.1 - 1.3e-10 40.7 5.2 2.3e-09 36.7 3.5 2.4 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 KII61914.1 - 4.2e-06 27.1 0.0 0.25 11.9 0.0 3.5 2 1 1 3 3 3 3 HEAT-like repeat Cnd1 PF12717.7 KII61914.1 - 0.00051 20.1 2.3 0.011 15.8 0.0 2.8 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KII61914.1 - 0.00078 19.5 0.0 4.2 7.9 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat Arm_2 PF04826.13 KII61914.1 - 0.0059 16.1 8.8 0.011 15.2 1.6 2.9 1 1 2 3 3 3 1 Armadillo-like Arm_3 PF16186.5 KII61918.1 - 0.00046 19.7 3.9 0.0013 18.3 3.9 1.8 1 1 0 1 1 1 1 Atypical Arm repeat DRIM PF07539.12 KII61918.1 - 0.0094 14.3 0.1 0.01 14.2 0.1 1.0 1 0 0 1 1 1 1 Down-regulated in metastasis EF-hand_2 PF09068.11 KII61918.1 - 0.23 11.6 1.8 2.9 8.0 1.8 2.0 1 1 0 1 1 1 0 EF hand Sortilin_C PF15901.5 KII61919.1 - 3.6e-10 40.5 0.5 6.3e-10 39.7 0.5 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII61919.1 - 0.017 13.9 1.3 0.062 12.1 1.2 1.7 1 1 1 2 2 2 0 Sortilin, neurotensin receptor 3, SNAP PF14938.6 KII61921.1 - 2.7e-06 27.0 0.1 3.4e-06 26.7 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII61921.1 - 0.024 14.9 0.2 0.033 14.5 0.2 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 KII61921.1 - 0.14 12.3 0.2 2.8 8.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat NSF PF02071.20 KII61921.1 - 0.79 10.7 6.1 11 7.3 0.3 3.3 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat Glyco_trans_A_1 PF09318.10 KII61922.1 - 0.0025 17.6 1.7 0.004 16.9 1.7 1.3 1 0 0 1 1 1 1 Glycosyl transferase 1 domain A DUF2274 PF10038.9 KII61922.1 - 0.097 13.1 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) HTH_Tnp_4 PF13613.6 KII61923.1 - 0.016 14.9 0.0 0.088 12.5 0.0 2.3 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease RT_RNaseH_2 PF17919.1 KII61927.1 - 2.7e-31 107.5 0.0 6.2e-31 106.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII61927.1 - 1.6e-28 99.0 0.0 3.6e-28 97.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII61927.1 - 4.2e-28 98.4 0.0 7.1e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII61927.1 - 1.7e-22 79.8 0.1 7.5e-22 77.8 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII61927.1 - 4.2e-15 55.6 0.9 1.6e-14 53.7 0.9 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII61927.1 - 0.00016 22.1 0.0 0.00038 21.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 KII61927.1 - 0.00048 19.9 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII61927.1 - 0.0082 16.4 0.0 0.026 14.9 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.10 KII61927.1 - 0.021 15.0 0.1 0.079 13.2 0.1 2.1 1 0 0 1 1 1 0 H2C2 zinc finger Asp_protease_2 PF13650.6 KII61927.1 - 0.032 14.9 0.0 0.079 13.6 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease DDE_Tnp_IS1595 PF12762.7 KII61929.1 - 3.9e-05 23.7 0.0 7e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF4679 PF15728.5 KII61931.1 - 0.042 12.9 0.3 0.06 12.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) ComFB PF10719.9 KII61932.1 - 0.02 15.0 0.1 0.028 14.5 0.1 1.3 1 0 0 1 1 1 0 Late competence development protein ComFB Tetraspanin PF00335.20 KII61935.1 - 3.8e-15 56.2 16.5 7.4e-15 55.3 16.8 1.4 1 1 0 1 1 1 1 Tetraspanin family DUF2206 PF09971.9 KII61935.1 - 3.3 6.4 10.0 13 4.4 0.1 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) DDE_3 PF13358.6 KII61936.1 - 0.02 14.7 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF4064 PF13273.6 KII61940.1 - 0.053 13.8 5.7 0.077 13.3 3.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF2909 PF11137.8 KII61940.1 - 0.08 12.9 6.3 0.77 9.7 1.3 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2909) DUF4293 PF14126.6 KII61941.1 - 0.67 10.2 7.2 0.11 12.7 1.7 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) ABC2_membrane_5 PF13346.6 KII61941.1 - 0.84 9.2 15.8 0.38 10.3 8.9 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein ERGIC_N PF13850.6 KII61941.1 - 1.6 9.1 5.0 1.3 9.4 0.2 2.4 2 1 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF4064 PF13273.6 KII61941.1 - 4.9 7.5 12.4 0.33 11.3 5.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF5641 PF18701.1 KII61942.1 - 0.0097 16.0 0.1 0.016 15.4 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) DUF1392 PF07154.11 KII61942.1 - 0.078 13.1 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1392) Myosin_N PF02736.19 KII61942.1 - 0.13 12.1 0.1 0.22 11.4 0.1 1.3 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain gag-asp_proteas PF13975.6 KII61943.1 - 0.00091 19.7 0.0 0.0017 18.9 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII61943.1 - 0.0012 18.8 1.9 0.0012 18.8 1.9 2.6 2 0 0 2 2 2 1 Zinc knuckle Asp_protease_2 PF13650.6 KII61943.1 - 0.0059 17.2 0.0 0.014 16.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease DUF4064 PF13273.6 KII61944.1 - 0.035 14.4 1.6 0.035 14.4 1.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) ASTN_2_hairpin PF18577.1 KII61945.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Astrotactin-2 C-terminal beta-hairpin domain DUF4064 PF13273.6 KII61945.1 - 0.11 12.8 10.6 0.65 10.3 4.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) EamA PF00892.20 KII61946.1 - 0.3 11.3 4.8 2.1 8.5 1.2 2.1 1 1 1 2 2 2 0 EamA-like transporter family DDE_3 PF13358.6 KII61947.1 - 1.3e-10 41.2 0.0 1.3e-08 34.7 0.0 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease NADH-u_ox-rdase PF10785.9 KII61948.1 - 0.029 15.1 0.6 0.029 15.1 0.6 2.3 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DDE_Tnp_IS1595 PF12762.7 KII61949.1 - 1.9e-15 57.2 0.1 2.3e-15 56.9 0.1 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF2207 PF09972.9 KII61949.1 - 0.044 12.6 0.1 0.043 12.6 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PGG PF13962.6 KII61949.1 - 0.059 13.2 0.2 0.086 12.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function PPR_1 PF12854.7 KII61950.1 - 0.21 11.3 2.5 0.36 10.6 2.5 1.3 1 0 0 1 1 1 0 PPR repeat DUF4064 PF13273.6 KII61951.1 - 0.41 10.9 10.0 0.17 12.2 6.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF4064 PF13273.6 KII61952.1 - 0.028 14.7 0.8 0.028 14.7 0.8 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF2254 PF10011.9 KII61953.1 - 0.14 11.0 0.7 0.18 10.6 0.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) EAL PF00563.20 KII61954.1 - 0.019 14.5 0.1 0.022 14.3 0.1 1.1 1 0 0 1 1 1 0 EAL domain CK2S PF15011.6 KII61954.1 - 0.049 13.5 0.2 0.063 13.2 0.2 1.1 1 0 0 1 1 1 0 Casein Kinase 2 substrate ProQ PF04352.13 KII61955.1 - 0.039 13.9 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 ProQ/FINO family DDE_3 PF13358.6 KII61959.1 - 0.00013 21.7 1.7 0.00026 20.8 1.7 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease EMP24_GP25L PF01105.24 KII61964.1 - 2.4e-23 83.0 0.7 2.6e-23 82.9 0.7 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Fcf2 PF08698.11 KII61965.1 - 2.2e-20 72.8 0.1 4.3e-20 71.9 0.1 1.4 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing S1FA PF04689.13 KII61965.1 - 0.6 10.3 3.4 1.1 9.4 0.2 2.5 3 0 0 3 3 3 0 DNA binding protein S1FA DUF3385 PF11865.8 KII61967.1 - 0.085 12.8 0.0 0.097 12.6 0.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) Glycos_transf_2 PF00535.26 KII61968.1 - 3.7e-37 127.7 0.4 6.9e-37 126.9 0.4 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KII61968.1 - 3.4e-14 53.3 0.0 6.1e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KII61968.1 - 1e-13 51.4 0.3 1.8e-13 50.6 0.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KII61968.1 - 0.0011 19.4 0.0 0.0036 17.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 2 HAP1_N PF04849.13 KII61968.1 - 0.0014 17.9 10.4 0.0014 17.9 10.4 1.5 2 0 0 2 2 2 1 HAP1 N-terminal conserved region Phage_GP20 PF06810.11 KII61968.1 - 0.036 13.9 1.8 0.064 13.1 1.8 1.5 1 0 0 1 1 1 0 Phage minor structural protein GP20 Dynactin_p22 PF07426.11 KII61968.1 - 0.044 13.6 11.6 0.046 13.6 3.5 2.4 1 1 1 2 2 2 0 Dynactin subunit p22 Spc7 PF08317.11 KII61968.1 - 0.054 12.4 7.3 0.089 11.7 7.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2570 PF10828.8 KII61968.1 - 0.068 13.0 5.0 0.047 13.5 3.1 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF2570) OmpH PF03938.14 KII61968.1 - 0.12 12.7 3.9 0.22 11.9 3.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) BRE1 PF08647.11 KII61968.1 - 0.13 12.4 9.6 0.7 10.0 7.3 2.7 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase ATG16 PF08614.11 KII61968.1 - 0.94 9.7 11.4 1.7 8.8 11.4 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) FAM76 PF16046.5 KII61968.1 - 1 8.6 5.0 1.5 8.1 5.0 1.2 1 0 0 1 1 1 0 FAM76 protein TMF_DNA_bd PF12329.8 KII61968.1 - 1.4 9.0 8.6 1.3 9.0 6.7 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 KII61968.1 - 1.4 8.9 13.6 0.62 10.1 10.1 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 KII61968.1 - 1.9 8.3 7.8 5.8 6.8 0.3 2.5 2 0 0 2 2 2 0 Septum formation initiator Csm1_N PF18504.1 KII61968.1 - 5 7.5 11.5 2.1 8.7 3.7 2.6 1 1 1 2 2 2 0 Csm1 N-terminal domain YabA PF06156.13 KII61968.1 - 7.7 7.2 7.1 17 6.1 7.1 1.6 1 0 0 1 1 1 0 Initiation control protein YabA Glycos_transf_1 PF00534.20 KII61969.1 - 1.2e-25 90.1 0.0 1.6e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 KII61969.1 - 9e-22 77.6 0.1 1.4e-21 77.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_4 PF13692.6 KII61969.1 - 1.4e-17 64.4 0.0 2.6e-17 63.5 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KII61969.1 - 2.2e-09 37.6 0.0 6.6e-09 36.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KII61969.1 - 1.4e-06 28.5 0.0 2.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 KII61969.1 - 0.23 11.9 0.0 0.35 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain DDE_3 PF13358.6 KII61972.1 - 2.6e-34 118.1 0.0 2.9e-34 117.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII61972.1 - 0.00028 21.1 0.0 0.00036 20.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_ISAZ013 PF07592.11 KII61972.1 - 0.002 17.2 0.1 0.0026 16.8 0.1 1.2 1 0 0 1 1 1 1 Rhodopirellula transposase DDE domain UTRA PF07702.13 KII61976.1 - 7.5e-34 116.6 0.0 1.1e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 UTRA domain GntR PF00392.21 KII61976.1 - 1.4e-19 69.5 0.1 2.3e-19 68.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_Crp_2 PF13545.6 KII61976.1 - 0.0067 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain GspL_C PF12693.7 KII61976.1 - 0.025 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 GspL periplasmic domain SBP_bac_1 PF01547.25 KII61977.1 - 0.00011 22.3 0.0 0.00012 22.1 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Homeodomain PF00046.29 KII61977.1 - 0.077 12.9 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Homeodomain Peptidase_M24_C PF16188.5 KII61977.1 - 0.12 12.4 0.0 0.49 10.5 0.0 1.8 2 0 0 2 2 2 0 C-terminal region of peptidase_M24 NYN PF01936.18 KII61978.1 - 1.6e-31 109.8 0.1 2.5e-31 109.1 0.1 1.3 1 0 0 1 1 1 1 NYN domain OST-HTH PF12872.7 KII61978.1 - 9e-16 57.5 0.0 1.5e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 OST-HTH/LOTUS domain PIN7 PF18475.1 KII61978.1 - 0.073 13.7 0.1 0.17 12.5 0.1 1.8 1 1 0 1 1 1 0 PIN domain DIM PF08194.12 KII61979.1 - 1.9 8.8 6.6 4.5 7.6 0.3 2.5 2 0 0 2 2 2 0 DIM protein Annexin PF00191.20 KII61980.1 - 5.1e-12 45.7 0.8 8.8e-05 22.5 0.0 3.6 4 0 0 4 4 4 3 Annexin Ist1 PF03398.14 KII61980.1 - 0.0028 17.6 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Forkhead PF00250.18 KII61980.1 - 0.087 13.1 0.4 7.9 6.8 0.0 2.9 2 1 1 3 3 3 0 Forkhead domain gag-asp_proteas PF13975.6 KII61981.1 - 1.9e-06 28.3 0.0 4.2e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII61981.1 - 0.00065 20.3 0.0 0.0015 19.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII61981.1 - 0.03 14.6 0.1 0.075 13.4 0.1 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF4656 PF15551.6 KII61981.1 - 0.034 13.7 0.5 0.055 13.0 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4656) Ribosomal_L36e PF01158.18 KII61981.1 - 0.037 14.3 0.1 0.14 12.4 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L36e Ferritin-like PF12902.7 KII61981.1 - 0.088 12.7 0.2 1.9 8.3 0.1 2.5 2 1 0 2 2 2 0 Ferritin-like DUF4494 PF14902.6 KII61981.1 - 0.094 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4494) zinc_ribbon_2 PF13240.6 KII61981.1 - 0.4 10.5 4.8 13 5.7 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-CCHC PF00098.23 KII61981.1 - 0.64 10.2 7.8 1.1 9.4 1.9 2.5 2 0 0 2 2 2 0 Zinc knuckle TNF PF00229.18 KII61983.1 - 0.0068 16.4 0.8 0.02 14.8 0.1 2.1 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family BLM10_mid PF16507.5 KII61985.1 - 0.017 13.8 0.1 0.018 13.7 0.1 1.1 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region Urb2 PF10441.9 KII61985.1 - 0.25 11.3 2.1 0.3 11.0 0.4 1.7 2 0 0 2 2 2 0 Urb2/Npa2 family zf-UBR PF02207.20 KII61988.1 - 3.5e-08 33.5 19.2 7.5e-08 32.4 19.2 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DUF3890 PF13029.6 KII61991.1 - 0.019 15.4 0.9 0.12 12.8 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3890) zf-UBR PF02207.20 KII61993.1 - 1.2e-11 44.5 14.1 1.2e-11 44.5 14.1 1.9 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-UBR PF02207.20 KII61994.1 - 7.6e-12 45.2 12.9 7.6e-12 45.2 12.9 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) SNAP PF14938.6 KII61996.1 - 6.3e-29 101.3 3.4 7.7e-29 101.0 3.4 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII61996.1 - 0.00083 19.6 0.2 0.093 13.0 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KII61996.1 - 0.0041 17.1 3.0 0.079 13.1 0.6 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KII61996.1 - 0.28 11.3 2.8 0.67 10.1 1.3 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 KII61996.1 - 0.33 11.7 1.8 4 8.3 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Kelch_6 PF13964.6 KII61997.1 - 0.18 12.1 1.2 3 8.3 0.1 2.3 1 1 1 2 2 2 0 Kelch motif Kelch_6 PF13964.6 KII61998.1 - 3.8e-24 84.1 4.2 3.2e-07 30.4 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII61998.1 - 1e-17 63.7 5.7 3.5e-06 26.9 0.2 3.4 3 1 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII61998.1 - 1.7e-17 63.2 4.0 0.00017 21.8 0.3 4.2 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII61998.1 - 2.6e-17 62.1 5.2 4e-05 23.1 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII61998.1 - 5.8e-15 55.0 4.7 0.00012 22.0 1.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII61998.1 - 1.4e-08 34.4 2.0 0.0072 16.3 0.1 3.4 3 0 0 3 3 3 2 Kelch motif rve PF00665.26 KII62002.1 - 0.00087 19.5 0.0 0.0011 19.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain GerPE PF10970.8 KII62005.1 - 0.027 14.6 0.1 0.034 14.3 0.1 1.2 1 0 0 1 1 1 0 Spore germination protein GerPE Nup35_RRM_2 PF14605.6 KII62005.1 - 0.085 12.9 0.3 0.23 11.5 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Intron_maturas2 PF01348.21 KII62006.1 - 0.032 14.2 0.3 0.044 13.7 0.3 1.3 1 1 0 1 1 1 0 Type II intron maturase RT_RNaseH_2 PF17919.1 KII62012.1 - 9.6e-40 134.7 0.0 2.8e-39 133.2 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII62012.1 - 2.8e-36 124.0 0.0 8.7e-36 122.4 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII62012.1 - 3.6e-18 65.4 1.5 3.6e-18 65.4 1.5 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII62012.1 - 7.2e-18 64.9 0.0 3.9e-17 62.6 0.0 2.3 3 0 0 3 3 3 1 Integrase core domain zf-H2C2 PF09337.10 KII62012.1 - 0.00082 19.5 0.0 0.0018 18.4 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII62012.1 - 0.004 16.9 0.0 0.0093 15.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII62012.1 - 0.013 15.5 0.0 0.037 14.1 0.0 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain SET_assoc PF11767.8 KII62012.1 - 0.091 12.4 0.1 0.52 10.0 0.0 2.3 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated BslA PF17735.1 KII62013.1 - 0.12 12.4 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Biofilm surface layer A PI3_PI4_kinase PF00454.27 KII62014.1 - 2.4e-41 142.2 1.5 3.2e-40 138.5 0.3 2.7 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KII62014.1 - 1.3e-08 34.5 0.5 2.8e-08 33.4 0.5 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 KII62014.1 - 0.056 12.8 0.1 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) NTP_transferase PF00483.23 KII62015.1 - 1.1e-46 159.4 0.0 1.5e-46 159.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KII62015.1 - 1.4e-12 48.3 0.0 1.7e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 KII62015.1 - 4.1e-11 42.1 12.2 6.6e-07 28.8 5.1 3.7 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KII62015.1 - 3.5e-05 23.5 10.9 0.13 12.1 6.7 3.9 4 1 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 KII62015.1 - 0.00076 17.7 1.0 0.0018 16.5 0.8 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 KII62015.1 - 0.016 14.2 5.2 0.16 10.9 2.9 2.4 2 1 0 2 2 2 0 L-fucokinase IspD PF01128.19 KII62015.1 - 0.034 13.9 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Peptidase_M16 PF00675.20 KII62016.1 - 6.2e-45 152.8 0.0 9e-45 152.3 0.0 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KII62016.1 - 9.3e-27 94.2 0.0 2.6e-26 92.8 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain DDE_3 PF13358.6 KII62017.1 - 1.1e-13 51.1 0.0 1.6e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_M17 PF00883.21 KII62018.1 - 2.4e-99 332.5 0.0 2.7e-99 332.4 0.0 1.0 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain UMP1 PF05348.11 KII62024.1 - 0.0033 17.6 0.1 0.0039 17.4 0.1 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 DUF3903 PF13043.6 KII62024.1 - 0.0045 16.7 0.0 0.0082 15.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3903) FtsK_alpha PF17854.1 KII62027.1 - 0.0025 17.9 0.0 0.0036 17.4 0.0 1.2 1 0 0 1 1 1 1 FtsK alpha domain NifW PF03206.14 KII62029.1 - 0.00079 19.9 0.0 1.8 9.1 0.0 2.4 2 1 0 2 2 2 2 Nitrogen fixation protein NifW TBX PF12598.8 KII62029.1 - 0.0032 18.2 1.4 3.1 8.6 0.1 2.2 2 0 0 2 2 2 2 T-box transcription factor Pro-NT_NN PF07421.11 KII62029.1 - 0.0076 16.5 0.8 3.2 8.0 0.1 2.2 2 0 0 2 2 2 2 Neurotensin/neuromedin N precursor ERF PF04404.12 KII62029.1 - 0.057 13.3 0.5 12 5.8 0.1 2.2 2 0 0 2 2 2 0 ERF superfamily DUF1666 PF07891.12 KII62029.1 - 0.062 13.0 5.3 2 8.0 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1666) MOEP19 PF16005.5 KII62029.1 - 0.087 12.8 1.4 7.1 6.7 0.1 2.3 2 0 0 2 2 2 0 KH-like RNA-binding domain Spem1 PF15670.5 KII62029.1 - 0.11 12.1 0.7 9.6 5.7 0.1 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 HetR_C PF18460.1 KII62029.1 - 0.7 9.9 4.3 37 4.3 0.0 3.5 3 1 1 4 4 4 0 Heterocyst differentiation regulator C-terminal Hood domain Ric8 PF10165.9 KII62029.1 - 1.4 7.9 8.2 1.1 8.2 0.7 3.1 3 1 1 4 4 4 0 Guanine nucleotide exchange factor synembryn malic PF00390.19 KII62030.1 - 0.017 15.0 0.0 0.055 13.3 0.0 1.8 1 0 0 1 1 1 0 Malic enzyme, N-terminal domain Ribosomal_L13e PF01294.18 KII62030.1 - 4.5 7.1 7.2 1.1 9.1 1.7 2.1 2 0 0 2 2 2 0 Ribosomal protein L13e PPV_E2_C PF00511.17 KII62031.1 - 0.13 12.4 0.3 0.13 12.4 0.3 2.0 2 1 0 2 2 2 0 E2 (early) protein, C terminal DDE_Tnp_IS1595 PF12762.7 KII62036.1 - 5.9e-14 52.3 0.1 7.9e-14 51.9 0.1 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF1356 PF07092.12 KII62039.1 - 0.0013 18.1 2.1 0.0028 17.0 2.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) S_locus_glycop PF00954.20 KII62039.1 - 2.9 8.5 6.6 19 5.8 0.3 3.3 3 1 0 3 3 3 0 S-locus glycoprotein domain bZIP_C PF12498.8 KII62039.1 - 7.4 7.6 10.4 2.4 9.1 6.3 2.2 1 1 1 2 2 2 0 Basic leucine-zipper C terminal MFS_1 PF07690.16 KII62044.1 - 0.0049 15.8 0.0 0.0053 15.7 0.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4040 PF13244.6 KII62044.1 - 0.01 16.0 0.4 0.019 15.1 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) Phage_int_SAM_3 PF14659.6 KII62048.1 - 0.19 12.0 1.6 4.8 7.5 0.0 2.1 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain DDE_1 PF03184.19 KII62050.1 - 8.2e-05 22.3 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII62050.1 - 0.0012 18.8 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_3 PF01381.22 KII62050.1 - 0.0028 17.7 0.0 0.0046 17.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix CENP-B_N PF04218.13 KII62050.1 - 0.0073 15.9 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_psq PF05225.16 KII62050.1 - 0.0098 15.6 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain LacI PF00356.21 KII62050.1 - 0.032 14.0 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family DDE_3 PF13358.6 KII62051.1 - 1.5e-05 24.8 0.0 1.8e-05 24.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DPCD PF14913.6 KII62051.1 - 0.0066 15.8 0.1 0.0087 15.4 0.1 1.2 1 0 0 1 1 1 1 DPCD protein family RVT_1 PF00078.27 KII62053.1 - 2.4e-27 95.9 0.1 4.2e-27 95.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 KII62053.1 - 1.3e-05 25.4 0.1 2.8e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII62053.1 - 3.5e-05 24.3 0.1 6.7e-05 23.4 0.1 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII62053.1 - 0.00053 20.6 0.0 0.00097 19.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Rogdi_lz PF10259.9 KII62053.1 - 0.01 15.3 0.0 0.13 11.7 0.0 2.3 2 0 0 2 2 2 0 Rogdi leucine zipper containing protein zf-CCHC PF00098.23 KII62053.1 - 0.011 15.8 2.1 0.011 15.8 2.1 2.8 2 0 0 2 2 2 0 Zinc knuckle RVP_2 PF08284.11 KII62053.1 - 0.024 14.4 0.2 0.052 13.3 0.2 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_3 PF13917.6 KII62053.1 - 0.61 10.1 10.0 0.16 12.0 1.7 2.6 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII62053.1 - 7.1 6.5 9.6 10 5.9 3.3 2.5 1 1 1 2 2 2 0 Zinc knuckle Mod_r PF07200.13 KII62055.1 - 0.0016 18.5 3.0 0.019 15.1 3.0 2.0 1 1 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein SKA2 PF16740.5 KII62055.1 - 3.6 7.4 8.0 8.5 6.2 1.3 2.2 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Elong-fact-P_C PF09285.11 KII62056.1 - 0.08 12.7 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 Elongation factor P, C-terminal DUF3685 PF12452.8 KII62057.1 - 0.045 13.4 0.1 0.16 11.7 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) SUKH_6 PF14568.6 KII62057.1 - 0.18 12.2 6.6 0.48 10.9 1.4 3.8 2 1 1 3 3 3 0 SMI1-KNR4 cell-wall RPAP3_C PF13877.6 KII62057.1 - 1.2 9.7 9.6 79 3.9 0.5 5.7 4 0 0 4 4 4 0 Potential Monad-binding region of RPAP3 RcsF PF16358.5 KII62058.1 - 0.093 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 RcsF lipoprotein DDE_3 PF13358.6 KII62059.1 - 4.8e-17 62.1 0.0 7.3e-09 35.5 0.2 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease Filament PF00038.21 KII62060.1 - 0.0025 17.5 2.3 0.0029 17.3 2.3 1.3 1 0 0 1 1 1 1 Intermediate filament protein DUF2730 PF10805.8 KII62060.1 - 0.019 15.0 0.9 0.033 14.3 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Spc7 PF08317.11 KII62060.1 - 0.064 12.1 5.5 0.079 11.8 5.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 KII62060.1 - 1.2 9.2 8.8 2.2 8.4 8.8 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HSCB_C PF07743.13 KII62060.1 - 1.3 9.5 4.3 2.2 8.9 1.2 2.4 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain PRKCSH-like PF12999.7 KII62061.1 - 9e-28 97.2 2.8 1.1e-27 97.0 2.8 1.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like Ldl_recept_a PF00057.18 KII62061.1 - 0.0055 16.9 5.2 0.0058 16.8 2.9 2.0 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A Importin_rep_6 PF18829.1 KII62061.1 - 0.11 12.7 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Importin repeat 6 DUF2207 PF09972.9 KII62062.1 - 0.047 12.5 0.0 0.061 12.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2627 PF11118.8 KII62062.1 - 0.082 13.5 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) DDR PF08841.10 KII62062.1 - 0.17 10.8 0.0 0.37 9.7 0.0 1.4 1 1 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain Adap_comp_sub PF00928.21 KII62064.1 - 2e-06 27.4 0.1 5.4e-06 26.0 0.1 1.7 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KII62064.1 - 9.9e-05 22.3 0.2 0.00016 21.6 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Mon1 PF03164.14 KII62064.1 - 0.0045 16.1 0.1 0.0061 15.7 0.1 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 EF-hand_1 PF00036.32 KII62065.1 - 1.5e-36 121.2 17.0 3.3e-10 38.8 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KII62065.1 - 7.7e-33 112.8 6.7 4.3e-17 62.3 0.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KII62065.1 - 2e-30 102.1 5.9 3e-10 39.2 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KII62065.1 - 2e-28 98.0 14.4 5.6e-14 51.7 2.5 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KII62065.1 - 2.3e-23 80.6 12.1 3e-09 35.9 0.1 4.2 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 KII62065.1 - 3e-11 43.6 2.8 7.7e-05 23.0 0.2 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KII62065.1 - 7.2e-11 42.2 0.4 0.00013 22.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KII62065.1 - 1.2e-10 41.2 5.5 8.7e-07 28.8 0.5 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 KII62065.1 - 1.9e-05 24.6 0.2 0.057 13.5 0.0 2.4 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 KII62065.1 - 0.00027 21.8 0.2 0.048 14.5 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 KII62065.1 - 0.00075 19.6 2.8 0.026 14.7 0.4 3.0 1 1 1 2 2 2 2 Dockerin type I domain TerB PF05099.13 KII62065.1 - 0.0012 18.8 0.8 0.033 14.2 0.1 2.2 2 0 0 2 2 2 1 Tellurite resistance protein TerB Caleosin PF05042.13 KII62065.1 - 0.0038 17.2 0.1 3.5 7.5 0.0 3.0 2 2 2 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 KII62065.1 - 0.0047 17.2 4.2 0.067 13.5 0.8 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb4 SurA_N_2 PF13623.6 KII62065.1 - 0.0067 16.3 2.5 0.58 10.0 0.3 2.2 2 0 0 2 2 2 2 SurA N-terminal domain DUF1296 PF06972.11 KII62065.1 - 0.012 15.7 1.6 1.1 9.4 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) DUF5580 PF17743.1 KII62065.1 - 0.02 13.5 0.1 0.026 13.1 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) RTX_C PF08339.10 KII62065.1 - 0.021 14.9 2.0 1.2 9.2 0.4 2.1 1 1 1 2 2 2 0 RTX C-terminal domain RhoGEF PF00621.20 KII62065.1 - 0.026 14.8 0.1 0.061 13.6 0.1 1.7 1 1 1 2 2 2 0 RhoGEF domain EF-hand_14 PF17959.1 KII62065.1 - 0.027 14.8 0.8 1.3 9.4 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain DUF3349 PF11829.8 KII62065.1 - 0.061 14.1 1.7 3.5 8.5 0.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) HrpJ PF07201.11 KII62065.1 - 0.26 11.6 1.7 0.67 10.2 0.2 1.9 2 0 0 2 2 2 0 HrpJ-like domain ARL2_Bind_BART PF11527.8 KII62065.1 - 7.2 6.8 11.9 6.9 6.8 1.3 2.7 1 1 1 2 2 2 0 The ARF-like 2 binding protein BART Helicase_C PF00271.31 KII62066.1 - 7.8e-12 45.5 3.0 8.4e-10 39.0 0.1 3.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 KII62066.1 - 0.00046 20.7 0.1 0.0019 18.8 0.1 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.6 KII62066.1 - 0.006 16.8 1.0 0.022 15.0 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4332) DNA_pol_lambd_f PF10391.9 KII62066.1 - 0.04 13.8 0.0 0.14 12.0 0.0 2.0 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda HTH_41 PF14502.6 KII62066.1 - 0.088 12.5 0.1 0.9 9.3 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain DNA_III_psi PF03603.13 KII62066.1 - 0.12 12.7 1.4 15 5.9 0.1 2.6 2 0 0 2 2 2 0 DNA polymerase III psi subunit DSBA PF01323.20 KII62066.1 - 0.21 11.3 1.6 2.4 7.9 0.7 2.2 2 0 0 2 2 2 0 DSBA-like thioredoxin domain DEAD PF00270.29 KII62067.1 - 7.3e-11 42.1 0.0 8.6e-11 41.9 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KII62067.1 - 2.3e-06 27.7 0.0 3.2e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 KII62067.1 - 0.056 12.7 0.0 0.075 12.3 0.0 1.1 1 0 0 1 1 1 0 SecA DEAD-like domain Nup84_Nup100 PF04121.13 KII62068.1 - 3.1e-54 184.3 3.9 4e-54 183.9 3.9 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 SIX1_SD PF16878.5 KII62068.1 - 0.13 12.8 2.4 0.32 11.5 0.3 2.7 2 0 0 2 2 2 0 Transcriptional regulator, SIX1, N-terminal SD domain STAT_int PF02865.17 KII62068.1 - 0.22 12.0 2.5 0.87 10.0 0.0 2.9 3 0 0 3 3 3 0 STAT protein, protein interaction domain TMEM154 PF15102.6 KII62070.1 - 0.0077 16.1 2.2 0.0077 16.1 2.2 2.2 1 1 1 2 2 2 1 TMEM154 protein family Baculo_11_kDa PF06143.11 KII62070.1 - 0.026 14.1 1.0 0.1 12.2 1.0 2.0 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF4577 PF15145.6 KII62070.1 - 0.043 13.8 0.1 6.8 6.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) DUF4389 PF14333.6 KII62070.1 - 0.17 11.8 2.5 0.33 10.9 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) Shisa PF13908.6 KII62070.1 - 1.5 9.0 4.0 0.74 10.0 0.6 2.0 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator ABC2_membrane_3 PF12698.7 KII62070.1 - 2.9 6.9 11.8 0.051 12.7 4.9 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF846 PF05832.12 KII62072.1 - 6.3e-37 126.7 15.2 7.5e-37 126.5 15.2 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Tudor-knot PF11717.8 KII62073.1 - 7.5e-17 61.0 0.3 1.3e-16 60.2 0.3 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 KII62073.1 - 0.0057 16.5 0.1 0.011 15.6 0.0 1.5 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain BLOC1_2 PF10046.9 KII62073.1 - 0.047 14.0 0.0 0.078 13.3 0.0 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MOZ_SAS PF01853.18 KII62074.1 - 2e-34 118.8 0.0 2e-34 118.8 0.0 1.0 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_7 PF13508.7 KII62074.1 - 0.0073 16.7 0.0 0.0081 16.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain WD40_4 PF16300.5 KII62075.1 - 2.3e-13 49.8 0.0 5.2e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Type of WD40 repeat UN_NPL4 PF11543.8 KII62075.1 - 0.12 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 WD40_4 PF16300.5 KII62076.1 - 6.9e-09 35.5 0.1 1.5e-08 34.4 0.0 1.6 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.32 KII62076.1 - 0.00024 21.8 2.5 1.5 9.8 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII62076.1 - 0.084 13.2 0.2 25 5.3 0.1 3.3 1 1 3 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1899 PF08953.11 KII62077.1 - 7.6e-06 25.7 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 KII62077.1 - 0.016 15.5 0.0 6.3 7.2 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain HSP20 PF00011.21 KII62079.1 - 1.6e-27 95.6 2.4 3.5e-15 56.0 0.2 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII62079.1 - 7.2e-05 22.3 0.1 0.014 15.0 0.0 2.4 2 0 0 2 2 2 2 HSP20-like domain found in ArsA Phenyl_P_gamma PF09662.10 KII62079.1 - 0.13 12.5 0.1 0.27 11.4 0.1 1.6 1 0 0 1 1 1 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) ATP_bind_1 PF03029.17 KII62080.1 - 4.7e-29 101.9 0.0 6e-29 101.5 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein DUF87 PF01935.17 KII62080.1 - 0.00039 20.6 0.1 0.00039 20.6 0.1 1.3 1 0 0 1 1 1 1 Helicase HerA, central domain CbiA PF01656.23 KII62080.1 - 0.00055 20.0 0.0 0.00058 19.9 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 KII62080.1 - 0.00056 19.6 0.1 0.0008 19.1 0.1 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain T2SSE PF00437.20 KII62080.1 - 0.00084 18.5 0.0 0.001 18.2 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.12 KII62080.1 - 0.0011 19.0 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 KII62080.1 - 0.0016 18.6 0.0 0.0016 18.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.18 KII62080.1 - 0.0016 17.7 0.0 0.0022 17.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_19 PF13245.6 KII62080.1 - 0.0022 18.3 0.0 0.0031 17.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII62080.1 - 0.0023 18.3 0.0 0.0033 17.8 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 KII62080.1 - 0.0051 16.0 0.0 0.0069 15.6 0.0 1.1 1 0 0 1 1 1 1 NB-ARC domain PRK PF00485.18 KII62080.1 - 0.0092 15.7 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_30 PF13604.6 KII62080.1 - 0.011 15.5 0.0 0.014 15.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 KII62080.1 - 0.02 14.4 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.6 KII62080.1 - 0.02 15.4 0.0 0.021 15.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KII62080.1 - 0.024 14.7 0.0 0.033 14.2 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KII62080.1 - 0.026 14.6 0.1 0.036 14.1 0.1 1.3 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 KII62080.1 - 0.026 14.1 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF463 PF04317.12 KII62080.1 - 0.031 13.2 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 MeaB PF03308.16 KII62080.1 - 0.033 13.2 0.0 0.043 12.8 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PduV-EutP PF10662.9 KII62080.1 - 0.035 13.8 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 KII62080.1 - 0.038 14.5 0.2 0.047 14.2 0.1 1.3 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.20 KII62080.1 - 0.04 13.8 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Trm56 PF01994.16 KII62080.1 - 0.042 13.8 0.0 0.44 10.5 0.0 2.1 2 1 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 AAA_22 PF13401.6 KII62080.1 - 0.043 14.1 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KII62080.1 - 0.061 13.7 0.1 0.11 12.9 0.1 1.5 1 1 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.18 KII62080.1 - 0.07 12.9 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CLP1_P PF16575.5 KII62080.1 - 0.072 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MobB PF03205.14 KII62080.1 - 0.072 13.0 0.1 0.092 12.6 0.1 1.3 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 KII62080.1 - 0.075 12.7 0.1 0.075 12.7 0.1 1.1 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KII62080.1 - 0.075 12.3 0.0 0.086 12.1 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 KII62080.1 - 0.1 13.1 0.2 0.17 12.4 0.1 1.4 1 1 0 1 1 1 0 ABC transporter Pox_A32 PF04665.12 KII62080.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein NTPase_1 PF03266.15 KII62080.1 - 0.14 12.0 0.2 0.21 11.5 0.2 1.2 1 0 0 1 1 1 0 NTPase Glycos_transf_1 PF00534.20 KII62080.1 - 0.16 11.5 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferases group 1 ATP_bind_1 PF03029.17 KII62081.1 - 4.7e-29 101.9 0.0 6e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein DUF87 PF01935.17 KII62081.1 - 0.00049 20.3 0.1 0.00054 20.1 0.1 1.2 1 0 0 1 1 1 1 Helicase HerA, central domain CbiA PF01656.23 KII62081.1 - 0.00055 20.0 0.0 0.00058 19.9 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 KII62081.1 - 0.00056 19.6 0.1 0.0008 19.1 0.1 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain T2SSE PF00437.20 KII62081.1 - 0.00062 18.9 0.0 0.00074 18.6 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.12 KII62081.1 - 0.0011 19.0 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 KII62081.1 - 0.0016 18.6 0.0 0.0016 18.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.18 KII62081.1 - 0.0016 17.8 0.0 0.0022 17.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_19 PF13245.6 KII62081.1 - 0.0022 18.3 0.0 0.0031 17.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII62081.1 - 0.0023 18.3 0.0 0.0033 17.8 0.0 1.2 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 KII62081.1 - 0.0045 16.2 0.0 0.0058 15.8 0.0 1.1 1 0 0 1 1 1 1 NB-ARC domain PRK PF00485.18 KII62081.1 - 0.0091 15.7 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_30 PF13604.6 KII62081.1 - 0.011 15.5 0.0 0.014 15.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 KII62081.1 - 0.02 14.4 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.6 KII62081.1 - 0.02 15.4 0.0 0.021 15.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KII62081.1 - 0.022 14.8 0.0 0.031 14.3 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KII62081.1 - 0.025 14.6 0.1 0.036 14.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 KII62081.1 - 0.026 14.1 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF463 PF04317.12 KII62081.1 - 0.031 13.2 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 MeaB PF03308.16 KII62081.1 - 0.031 13.2 0.0 0.04 12.9 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Trm56 PF01994.16 KII62081.1 - 0.035 14.0 0.0 0.44 10.5 0.0 2.2 2 1 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 PduV-EutP PF10662.9 KII62081.1 - 0.035 13.8 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation APS_kinase PF01583.20 KII62081.1 - 0.04 13.8 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_23 PF13476.6 KII62081.1 - 0.041 14.4 0.2 0.053 14.0 0.1 1.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KII62081.1 - 0.043 14.1 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KII62081.1 - 0.059 13.8 0.1 0.11 12.9 0.1 1.5 1 1 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.18 KII62081.1 - 0.07 12.9 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CLP1_P PF16575.5 KII62081.1 - 0.072 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MobB PF03205.14 KII62081.1 - 0.072 13.0 0.1 0.092 12.6 0.1 1.3 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 KII62081.1 - 0.075 12.8 0.1 0.075 12.7 0.1 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KII62081.1 - 0.079 12.2 0.0 0.091 12.0 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 KII62081.1 - 0.1 13.1 0.2 0.17 12.4 0.1 1.4 1 1 0 1 1 1 0 ABC transporter Pox_A32 PF04665.12 KII62081.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein NTPase_1 PF03266.15 KII62081.1 - 0.14 12.0 0.2 0.21 11.5 0.2 1.3 1 0 0 1 1 1 0 NTPase Glycos_transf_1 PF00534.20 KII62081.1 - 0.16 11.5 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferases group 1 Sugar_tr PF00083.24 KII62082.1 - 2.6e-37 128.8 11.4 4.5e-37 128.0 11.0 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII62082.1 - 8.3e-17 61.1 23.2 2.3e-16 59.7 23.2 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 KII62082.1 - 0.0083 14.7 16.9 0.052 12.1 1.0 2.8 2 1 0 2 2 2 2 MFS/sugar transport protein Ceramidase PF05875.12 KII62082.1 - 0.1 12.0 3.7 0.038 13.4 0.5 1.8 1 1 1 2 2 2 0 Ceramidase Sperm_Ag_HE2 PF05324.13 KII62082.1 - 0.19 12.2 1.0 11 6.6 0.1 2.7 2 0 0 2 2 2 0 Sperm antigen HE2 Pex24p PF06398.11 KII62082.1 - 0.36 9.8 2.2 0.54 9.2 2.2 1.4 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin Sugar_tr PF00083.24 KII62083.1 - 1.6e-15 56.9 1.2 1.9e-15 56.7 1.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Orf78 PF06024.12 KII62083.1 - 0.1 12.9 0.5 0.16 12.3 0.5 1.3 1 0 0 1 1 1 0 Orf78 (ac78) AKAP2_C PF15304.6 KII62084.1 - 0.018 14.3 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 A-kinase anchor protein 2 C-terminus Invas_SpaK PF03519.14 KII62084.1 - 0.031 14.3 0.0 0.04 14.0 0.0 1.2 1 0 0 1 1 1 0 Invasion protein B family PRCC PF10253.9 KII62091.1 - 0.1 13.4 0.0 0.14 12.9 0.0 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting WD40 PF00400.32 KII62092.1 - 0.3 12.0 2.1 3.9 8.5 0.0 2.9 2 1 0 2 2 2 0 WD domain, G-beta repeat MULE PF10551.9 KII62093.1 - 2.2e-08 34.4 0.0 3.8e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 MULE transposase domain DUF5022 PF16425.5 KII62095.1 - 0.00096 18.7 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5022) SIL1 PF16782.5 KII62095.1 - 0.022 14.0 3.6 0.032 13.5 0.6 2.3 2 1 1 3 3 3 0 Nucleotide exchange factor SIL1 Symplekin_C PF12295.8 KII62096.1 - 1.1e-50 172.3 7.5 1.7e-50 171.7 2.7 2.7 2 0 0 2 2 2 2 Symplekin tight junction protein C terminal TGF_beta PF00019.20 KII62097.1 - 5.4e-23 82.0 0.6 9.1e-23 81.2 0.6 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain Hormone_6 PF00236.18 KII62097.1 - 0.025 14.6 0.1 0.054 13.5 0.1 1.6 1 0 0 1 1 1 0 Glycoprotein hormone Serpin PF00079.20 KII62098.1 - 9.5e-42 143.6 0.4 1.1e-41 143.5 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) COMMD1_N PF17221.3 KII62099.1 - 0.011 16.0 0.6 0.18 12.1 0.1 2.2 2 0 0 2 2 2 0 COMMD1 N-terminal domain RRM_1 PF00076.22 KII62100.1 - 0.00017 21.3 0.0 0.00031 20.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 KII62100.1 - 0.06 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 RL domain PAP_assoc PF03828.19 KII62101.1 - 6.4e-11 42.3 0.1 2.2e-10 40.6 0.1 2.0 1 0 0 1 1 1 1 Cid1 family poly A polymerase RRM_1 PF00076.22 KII62101.1 - 0.0014 18.4 0.0 0.0039 17.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA_NucTransf2 PF09249.11 KII62101.1 - 0.0024 18.1 0.0 0.013 15.8 0.0 2.2 2 0 0 2 2 2 1 tRNA nucleotidyltransferase, second domain Ribosomal_S30 PF04758.14 KII62102.1 - 3.3e-20 72.0 10.8 4.5e-20 71.6 10.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S30 ubiquitin PF00240.23 KII62102.1 - 7.8e-11 41.6 0.0 1.1e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KII62102.1 - 0.012 15.4 0.2 0.02 14.7 0.2 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PAP_assoc PF03828.19 KII62103.1 - 7.3e-13 48.5 0.3 1.9e-12 47.2 0.3 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase RRM_1 PF00076.22 KII62103.1 - 0.00031 20.5 0.1 0.00074 19.3 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA_NucTransf2 PF09249.11 KII62103.1 - 0.013 15.7 0.0 0.042 14.1 0.0 1.8 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain zf-C2H2_2 PF12756.7 KII62103.1 - 0.019 15.3 0.2 0.019 15.3 0.2 3.2 4 0 0 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF563 PF04577.14 KII62103.1 - 0.052 13.7 0.0 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF563) zf-BED PF02892.15 KII62103.1 - 0.098 12.7 0.1 0.34 11.0 0.1 1.9 1 0 0 1 1 1 0 BED zinc finger zf-met PF12874.7 KII62103.1 - 0.5 10.8 8.2 0.74 10.3 3.5 3.4 2 1 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KII62103.1 - 4.8 7.6 8.9 0.6 10.5 2.5 3.0 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding His_Phos_2 PF00328.22 KII62104.1 - 8.1e-93 311.8 1.6 9.2e-93 311.6 0.5 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 KII62104.1 - 6.7e-23 80.7 0.0 1.8e-22 79.3 0.0 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 KII62104.1 - 5.8e-05 22.8 0.0 0.00013 21.6 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain DUF29 PF01724.16 KII62104.1 - 0.55 10.5 3.0 1.6 9.0 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF29 PSI PF01437.25 KII62106.1 - 0.04 14.5 8.0 0.073 13.6 8.0 1.5 1 0 0 1 1 1 0 Plexin repeat stn_TNFRSF12A PF12191.8 KII62106.1 - 0.04 14.1 0.0 0.075 13.3 0.0 1.4 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF2207 PF09972.9 KII62106.1 - 0.046 12.5 0.1 0.19 10.4 0.1 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) PRP38 PF03371.15 KII62112.1 - 2.1e-57 193.8 1.1 2.7e-57 193.4 1.1 1.1 1 0 0 1 1 1 1 PRP38 family TAF8_C PF10406.9 KII62113.1 - 5.1e-06 27.0 0.1 1.2e-05 25.8 0.1 1.7 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term GYF PF02213.16 KII62114.1 - 1.3e-08 34.3 1.9 1.3e-08 34.3 1.9 1.9 2 0 0 2 2 2 1 GYF domain Pkinase_Tyr PF07714.17 KII62115.1 - 1.1e-28 100.3 0.0 1e-26 93.8 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KII62115.1 - 8.7e-17 61.3 0.0 6.6e-15 55.2 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Kringle PF00051.18 KII62115.1 - 3.2e-15 56.2 0.7 9.8e-15 54.6 0.3 2.1 2 0 0 2 2 2 1 Kringle domain Pkinase_fungal PF17667.1 KII62115.1 - 0.11 11.3 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 KII62115.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RT_RNaseH_2 PF17919.1 KII62116.1 - 3.4e-34 116.9 0.0 1.3e-33 114.9 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII62116.1 - 2.2e-29 101.8 0.0 1.5e-28 99.2 0.0 2.2 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase IRS PF02174.17 KII62116.1 - 0.057 13.3 0.1 0.26 11.2 0.0 2.1 3 0 0 3 3 3 0 PTB domain (IRS-1 type) Integrase_H2C2 PF17921.1 KII62117.1 - 4.7e-09 36.2 1.1 8.8e-09 35.3 1.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain Glycos_transf_3 PF00591.21 KII62117.1 - 0.14 11.7 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain Laminin_G_3 PF13385.6 KII62119.1 - 2.6e-07 30.9 0.0 4.4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4704 PF15787.5 KII62119.1 - 0.00011 21.5 8.4 0.00049 19.4 3.1 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF4704) DUF1539 PF07560.11 KII62119.1 - 0.012 15.7 7.2 0.19 11.8 0.0 4.3 3 2 0 3 3 3 0 Domain of Unknown Function (DUF1539) DUF1981 PF09324.10 KII62119.1 - 0.17 11.8 3.0 0.78 9.6 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) Hexokinase_2 PF03727.16 KII62120.1 - 3e-69 233.1 0.0 3.9e-69 232.7 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII62120.1 - 4.2e-51 173.7 0.0 6.5e-51 173.1 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Aminotran_5 PF00266.19 KII62122.1 - 6.4e-15 55.0 0.1 1.3e-14 54.0 0.1 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 KII62122.1 - 1.1e-05 24.8 0.2 1.7e-05 24.2 0.2 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KII62122.1 - 0.086 11.4 0.3 0.13 10.8 0.3 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Gar1 PF04410.14 KII62123.1 - 1.8e-10 40.8 0.1 3.5e-10 39.9 0.1 1.5 1 1 0 1 1 1 1 Gar1/Naf1 RNA binding region Ribosomal_L34e PF01199.18 KII62124.1 - 4.2e-44 148.8 5.0 4.9e-44 148.6 5.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L34e His_Me_b4a2 PF18275.1 KII62124.1 - 0.03 14.4 0.1 0.064 13.3 0.1 1.6 1 0 0 1 1 1 0 His-Me finger endonuclease beta4-alpha2 domain BH4 PF02180.17 KII62125.1 - 1.3 8.9 4.2 3.1 7.7 0.1 2.6 2 0 0 2 2 2 0 Bcl-2 homology region 4 LAP1C PF05609.12 KII62127.1 - 0.001 18.3 9.8 0.0013 18.0 9.8 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) LapA_dom PF06305.11 KII62127.1 - 0.039 13.8 0.1 0.065 13.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Mitofilin PF09731.9 KII62127.1 - 0.86 8.4 20.2 1.1 8.0 20.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.9 KII62127.1 - 2.1 6.8 15.3 2.5 6.5 15.3 1.1 1 0 0 1 1 1 0 Macoilin family PepSY_TM PF03929.16 KII62127.1 - 3 7.4 4.1 14 5.2 4.1 2.0 1 1 0 1 1 1 0 PepSY-associated TM region PepX_N PF09168.10 KII62128.1 - 0.79 10.1 5.3 1.2 9.5 0.1 3.5 3 0 0 3 3 3 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal TBCA PF02970.16 KII62129.1 - 0.0032 17.8 3.9 0.0032 17.8 3.9 2.8 3 1 0 3 3 2 1 Tubulin binding cofactor A Phytochelatin PF05023.14 KII62129.1 - 0.09 12.0 6.5 2 7.6 0.9 2.9 2 1 1 3 3 3 0 Phytochelatin synthase MCPsignal PF00015.21 KII62129.1 - 0.17 11.7 8.4 0.13 12.0 0.9 3.1 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CREPT PF16566.5 KII62129.1 - 0.24 11.6 19.0 0.65 10.2 5.3 3.6 3 1 1 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour DUF948 PF06103.11 KII62129.1 - 0.3 11.4 10.4 13 6.1 0.8 4.3 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF883 PF05957.13 KII62129.1 - 0.48 11.1 4.9 7.6 7.2 0.5 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF465 PF04325.13 KII62129.1 - 0.59 10.2 5.4 0.21 11.7 1.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF465) NPV_P10 PF05531.12 KII62129.1 - 1.6 9.2 6.3 1.5 9.3 0.1 3.3 4 1 0 4 4 3 0 Nucleopolyhedrovirus P10 protein CALCOCO1 PF07888.11 KII62129.1 - 1.8 7.3 15.4 0.19 10.5 0.9 2.4 3 0 0 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like V-SNARE PF05008.15 KII62129.1 - 2 8.8 11.9 1.1 9.7 3.9 3.1 2 2 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Laminin_II PF06009.12 KII62129.1 - 3.3 7.7 14.3 0.65 10.0 3.3 3.0 3 0 0 3 3 3 0 Laminin Domain II Jnk-SapK_ap_N PF09744.9 KII62129.1 - 3.8 7.7 19.1 0.15 12.3 4.7 2.7 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF745 PF05335.13 KII62129.1 - 4.8 6.9 12.7 0.75 9.5 2.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF745) Ribosomal_L17 PF01196.19 KII62129.1 - 5.1 8.1 6.4 1e+02 3.9 6.0 2.7 1 1 0 1 1 1 0 Ribosomal protein L17 BORCS7 PF16088.5 KII62129.1 - 5.4 7.3 14.3 2.6 8.4 2.7 3.3 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 7 Seryl_tRNA_N PF02403.22 KII62129.1 - 7.2 6.9 14.9 0.062 13.5 2.5 2.9 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 KII62129.1 - 7.5 7.1 18.3 4.9 7.7 4.3 2.9 2 1 1 3 3 3 0 Apg6 coiled-coil region WD40 PF00400.32 KII62130.1 - 1.8e-05 25.4 1.3 0.00064 20.5 0.0 3.7 4 1 1 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII62130.1 - 0.1 12.9 0.0 3.9 7.8 0.0 2.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4371 PF14291.6 KII62132.1 - 0.0047 16.6 0.0 0.0095 15.6 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4371) V_ATPase_I PF01496.19 KII62134.1 - 3.5e-192 640.5 12.7 1.1e-191 638.8 12.7 1.6 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family WD40 PF00400.32 KII62135.1 - 0.0015 19.3 4.0 0.14 13.1 0.7 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat ABC_tran PF00005.27 KII62136.1 - 4.6e-22 79.0 0.0 6.5e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KII62136.1 - 4.2e-08 33.4 0.3 0.00011 22.1 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KII62136.1 - 1.8e-05 24.3 0.0 0.007 15.8 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 KII62136.1 - 6.6e-05 23.2 0.1 0.0001 22.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII62136.1 - 0.00048 20.5 0.0 0.00068 20.1 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KII62136.1 - 0.0012 18.8 0.2 0.0023 17.9 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase Septin PF00735.18 KII62136.1 - 0.0024 17.2 0.0 0.003 16.9 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KII62136.1 - 0.0024 18.0 0.0 0.0054 16.8 0.0 1.6 2 0 0 2 2 1 1 50S ribosome-binding GTPase NACHT PF05729.12 KII62136.1 - 0.0032 17.4 0.2 0.0063 16.4 0.2 1.5 1 0 0 1 1 1 1 NACHT domain SbcCD_C PF13558.6 KII62136.1 - 0.0042 17.3 0.0 0.023 14.9 0.0 2.0 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit cobW PF02492.19 KII62136.1 - 0.0044 16.6 0.0 0.0086 15.7 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 KII62136.1 - 0.0046 16.7 0.4 0.0066 16.2 0.1 1.7 2 1 0 2 2 1 1 AAA domain NTPase_1 PF03266.15 KII62136.1 - 0.005 16.8 0.2 1.3 8.9 0.1 2.2 2 0 0 2 2 2 1 NTPase AAA_29 PF13555.6 KII62136.1 - 0.0093 15.7 0.1 0.017 14.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 KII62136.1 - 0.018 15.0 0.1 1.5 8.8 0.1 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 KII62136.1 - 0.021 15.2 0.8 0.25 11.8 0.8 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 KII62136.1 - 0.021 14.7 0.1 0.041 13.8 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRPRB PF09439.10 KII62136.1 - 0.03 13.7 0.1 0.095 12.1 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Roc PF08477.13 KII62136.1 - 0.032 14.4 0.0 0.068 13.4 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Pox_A32 PF04665.12 KII62136.1 - 0.035 13.6 0.1 0.076 12.5 0.1 1.6 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_15 PF13175.6 KII62136.1 - 0.035 13.8 0.5 6.8 6.3 0.1 2.1 1 1 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 KII62136.1 - 0.045 14.0 0.0 0.099 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 KII62136.1 - 0.045 13.5 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 KII62136.1 - 0.047 13.7 0.0 0.84 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KII62136.1 - 0.053 14.0 0.2 0.13 12.8 0.2 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KII62136.1 - 0.058 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 KII62136.1 - 0.06 13.5 0.2 0.079 13.1 0.2 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KII62136.1 - 0.073 12.8 0.1 7.4 6.3 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein TniB PF05621.11 KII62136.1 - 0.076 12.4 0.1 0.47 9.8 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein FtsK_SpoIIIE PF01580.18 KII62136.1 - 0.091 12.1 0.2 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family NB-ARC PF00931.22 KII62136.1 - 0.1 11.8 0.2 0.19 10.9 0.2 1.4 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 KII62136.1 - 0.11 12.4 0.1 0.28 11.1 0.0 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain RuvB_N PF05496.12 KII62136.1 - 0.12 12.2 0.1 0.86 9.3 0.1 2.1 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 KII62136.1 - 0.2 11.4 0.0 0.5 10.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KII62136.1 - 0.22 11.0 0.9 0.59 9.6 0.3 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region LRRNT PF01462.18 KII62137.1 - 0.028 14.1 4.0 0.14 11.9 1.0 2.4 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Mesd PF10185.9 KII62138.1 - 0.00025 21.0 0.3 0.00025 21.0 0.3 2.0 1 1 1 2 2 2 1 Chaperone for wingless signalling and trafficking of LDL receptor HARP PF07443.13 KII62138.1 - 0.32 10.7 4.2 1.2 8.8 0.2 2.8 2 1 0 2 2 2 0 HepA-related protein (HARP) DUF4211 PF13926.6 KII62140.1 - 1.3 9.1 8.0 5.2 7.1 8.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4211) RT_RNaseH_2 PF17919.1 KII62141.1 - 1.2e-12 47.7 0.0 1.8e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII62141.1 - 0.00014 22.1 0.0 0.00026 21.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PBP-Tp47_a PF14889.6 KII62141.1 - 0.081 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a DUF3141 PF11339.8 KII62143.1 - 0.054 11.9 0.1 0.055 11.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) HMG-CoA_red PF00368.18 KII62144.1 - 3.9e-104 348.6 0.2 5.1e-104 348.2 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase B56 PF01603.20 KII62145.1 - 1.6e-44 152.5 20.7 1.9e-19 69.9 3.9 4.2 2 1 2 4 4 4 4 Protein phosphatase 2A regulatory B subunit (B56 family) TetR_C_19 PF17924.1 KII62145.1 - 0.0058 17.2 0.9 5.2 7.7 0.1 3.1 2 1 1 3 3 3 2 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 KII62146.1 - 8.9e-41 137.1 21.8 8.7e-10 39.0 0.1 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII62146.1 - 3e-12 46.7 0.0 0.0048 17.2 0.0 4.2 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KII62146.1 - 4e-06 26.0 0.1 0.85 8.5 0.0 4.2 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KII62146.1 - 0.0015 17.3 3.4 0.22 10.2 0.3 3.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 SPOC PF07744.13 KII62148.1 - 1.4e-18 67.3 0.0 2.2e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 SPOC domain PHO4 PF01384.20 KII62149.1 - 2.1e-23 82.9 5.7 2.3e-23 82.8 5.7 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF4239 PF14023.6 KII62149.1 - 0.034 13.9 0.2 0.061 13.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Cyclin_C_2 PF16899.5 KII62151.1 - 3.8e-07 30.5 0.1 1.6e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 KII62151.1 - 1e-05 25.3 0.3 1.7e-05 24.6 0.3 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Tetraspanin PF00335.20 KII62153.1 - 1.6e-25 90.2 13.2 2e-25 89.9 13.2 1.0 1 0 0 1 1 1 1 Tetraspanin family Reticulon PF02453.17 KII62153.1 - 0.0041 17.1 0.8 0.0041 17.1 0.8 2.0 3 0 0 3 3 3 1 Reticulon MiAMP1 PF09117.10 KII62153.1 - 0.015 15.5 1.4 0.14 12.4 0.1 2.2 2 0 0 2 2 2 0 MiAMP1 ABC_export PF16962.5 KII62153.1 - 0.18 10.2 8.1 0.069 11.6 5.2 1.7 2 0 0 2 2 2 0 Putative ABC exporter CoA_binding_3 PF13727.6 KII62153.1 - 0.83 9.6 3.3 0.25 11.3 0.2 1.8 2 0 0 2 2 2 0 CoA-binding domain MgtE PF01769.16 KII62153.1 - 0.98 9.8 11.6 0.42 11.0 8.3 2.0 2 0 0 2 2 2 0 Divalent cation transporter MSP1a PF11670.8 KII62153.1 - 3.5 6.9 7.1 6.5 6.0 0.8 2.1 1 1 1 2 2 2 0 Major surface protein 1a (MSP1a) PLAC8 PF04749.17 KII62154.1 - 2.1e-14 54.3 11.5 2.5e-14 54.1 11.5 1.1 1 0 0 1 1 1 1 PLAC8 family Fibrillarin PF01269.17 KII62155.1 - 6.6e-105 349.2 0.0 8.4e-105 348.9 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 KII62155.1 - 8.4e-06 25.6 0.0 1.3e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 KII62155.1 - 0.019 14.7 0.1 0.034 13.9 0.1 1.3 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Shadoo PF14999.6 KII62155.1 - 3.7 7.7 14.5 0.051 13.7 4.7 2.3 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective RRM_1 PF00076.22 KII62157.1 - 4.6e-13 48.8 0.0 9.2e-13 47.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Actin PF00022.19 KII62158.1 - 3.6e-62 210.3 0.0 1.2e-61 208.6 0.0 1.7 1 1 0 1 1 1 1 Actin MOZ_SAS PF01853.18 KII62159.1 - 2e-77 258.9 0.2 2.8e-77 258.4 0.2 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KII62159.1 - 1.4e-21 75.8 6.1 3.3e-21 74.6 6.1 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 KII62159.1 - 2.2e-17 62.7 0.3 4.6e-17 61.6 0.3 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 KII62159.1 - 0.00041 20.7 0.0 0.00091 19.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KII62159.1 - 0.057 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family FR47 PF08445.10 KII62159.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein zf-C2H2 PF00096.26 KII62159.1 - 0.19 12.2 1.5 0.71 10.5 1.5 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII62159.1 - 2.8 9.0 5.8 1.8 9.6 3.0 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Tetraspanin PF00335.20 KII62162.1 - 2.2e-12 47.2 14.9 2.8e-12 46.8 14.9 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF2254 PF10011.9 KII62162.1 - 5.9 5.6 5.9 7.7 5.2 5.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Tetraspanin PF00335.20 KII62163.1 - 7.2e-17 61.9 14.1 8.6e-17 61.6 14.1 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2070 PF09843.9 KII62163.1 - 6.3 5.0 12.8 9.4 4.4 12.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Tetraspanin PF00335.20 KII62164.1 - 6.4e-09 35.9 9.8 7.8e-09 35.6 9.8 1.0 1 0 0 1 1 1 1 Tetraspanin family RVT_1 PF00078.27 KII62166.1 - 5.6e-10 39.1 1.2 1e-09 38.3 1.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PurA PF04845.13 KII62168.1 - 3.4e-07 29.8 0.2 6.7e-05 22.3 0.4 2.4 2 1 0 2 2 2 2 PurA ssDNA and RNA-binding protein DUF809 PF05663.11 KII62173.1 - 0.025 14.7 2.6 0.029 14.5 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF809) CDC45 PF02724.14 KII62173.1 - 0.055 11.8 3.2 0.052 11.8 3.2 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 KII62173.1 - 0.064 12.6 7.9 0.072 12.4 7.9 1.2 1 0 0 1 1 1 0 NOA36 protein Myc_N PF01056.18 KII62173.1 - 0.18 11.7 6.9 0.22 11.4 6.9 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Pes-10 PF07149.11 KII62173.1 - 0.94 8.5 6.5 0.92 8.5 6.5 1.2 1 0 0 1 1 1 0 Pes-10 Pox_Ag35 PF03286.14 KII62173.1 - 1.7 8.4 6.1 2.2 8.0 6.1 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Sigma70_ner PF04546.13 KII62173.1 - 2.6 7.9 10.7 3.2 7.6 10.7 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Prefoldin PF02996.17 KII62174.1 - 4.2e-22 78.3 0.5 5.8e-22 77.9 0.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 KII62174.1 - 0.00025 20.9 0.4 0.0019 18.1 0.0 2.2 2 0 0 2 2 2 1 Prefoldin subunit RecG_N PF17190.4 KII62174.1 - 0.13 13.0 5.2 0.32 11.7 0.8 2.2 2 0 0 2 2 2 0 RecG N-terminal helical domain XPG_I PF00867.18 KII62175.1 - 0.057 13.8 0.1 0.12 12.8 0.1 1.6 1 1 1 2 2 2 0 XPG I-region Serpin PF00079.20 KII62176.1 - 5.2e-16 58.9 0.5 5.7e-15 55.5 0.5 1.9 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Kelch_6 PF13964.6 KII62177.1 - 1.1e-26 92.2 13.8 9.2e-06 25.8 0.1 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KII62177.1 - 1.9e-22 79.0 12.7 0.00012 22.0 0.1 5.2 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII62177.1 - 4.2e-19 67.9 11.6 6.1e-05 22.5 0.2 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 KII62177.1 - 2.8e-15 56.1 13.3 0.00094 19.4 0.3 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KII62177.1 - 7.8e-15 54.2 10.4 0.007 16.3 0.1 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.6 KII62177.1 - 3.6e-10 39.6 7.9 0.00074 19.4 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Glyco_transf_7N PF13733.6 KII62179.1 - 2.9e-25 88.4 0.6 5.4e-25 87.6 0.6 1.5 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 KII62179.1 - 9.8e-16 57.2 0.0 2.2e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase NPHI_C PF08469.10 KII62180.1 - 0.049 13.6 0.0 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 Nucleoside triphosphatase I C-terminal HTH_Tnp_ISL3 PF13542.6 KII62182.1 - 0.002 17.5 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 Cu-binding_MopE PF11617.8 KII62182.1 - 0.025 14.7 0.7 0.052 13.7 0.7 1.6 1 0 0 1 1 1 0 Putative metal-binding motif HTH_23 PF13384.6 KII62182.1 - 0.048 13.5 0.0 0.088 12.6 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Fimbrial PF00419.20 KII62184.1 - 1.3e-16 61.2 0.0 1.6e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Fimbrial protein DUF4402 PF14352.6 KII62184.1 - 0.076 13.7 0.8 0.12 13.1 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4402) PapC_N PF13954.6 KII62185.1 - 4.1e-38 130.7 0.0 4.9e-38 130.4 0.0 1.1 1 0 0 1 1 1 1 PapC N-terminal domain Fimbrial PF00419.20 KII62186.1 - 3.5e-18 66.3 3.5 5.1e-18 65.8 3.5 1.2 1 0 0 1 1 1 1 Fimbrial protein Fimbrial PF00419.20 KII62187.1 - 3.2e-19 69.7 5.0 3.7e-19 69.5 5.0 1.0 1 0 0 1 1 1 1 Fimbrial protein GerE PF00196.19 KII62188.1 - 0.00013 21.5 0.0 0.0002 20.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family DUF4762 PF15959.5 KII62189.1 - 1.9e-26 91.8 12.5 3.3e-26 91.0 12.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4762) DSBA PF01323.20 KII62189.1 - 8.8e-10 38.7 0.8 1.4e-08 34.7 0.2 2.1 1 1 1 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 KII62189.1 - 0.00077 19.7 0.5 0.0019 18.4 0.5 1.7 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_5 PF13743.6 KII62189.1 - 0.0011 18.7 0.1 0.0021 17.8 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 KII62189.1 - 0.0043 17.1 0.5 2.3 8.3 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin domain Ost5 PF05251.12 KII62189.1 - 0.048 13.9 1.8 0.1 12.9 1.8 1.5 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 DUF3311 PF11755.8 KII62189.1 - 0.14 12.1 1.1 0.34 10.9 1.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3311) NAD_binding_9 PF13454.6 KII62190.1 - 2.8e-34 118.4 0.0 1.2e-33 116.3 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding OCD_Mu_crystall PF02423.15 KII62190.1 - 3e-05 23.1 0.0 0.00038 19.5 0.0 2.4 2 1 0 2 2 2 1 Ornithine cyclodeaminase/mu-crystallin family F420_oxidored PF03807.17 KII62190.1 - 0.0063 17.1 0.3 0.032 14.8 0.1 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 KII62190.1 - 0.0083 16.9 0.1 0.13 13.0 0.1 2.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold 3HCDH_N PF02737.18 KII62190.1 - 0.086 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K_oxygenase PF13434.6 KII62190.1 - 0.21 10.7 0.2 14 4.7 0.1 2.8 3 1 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) PALP PF00291.25 KII62191.1 - 1.5e-12 47.5 0.0 2.1e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DAO PF01266.24 KII62192.1 - 1.5e-14 54.4 0.4 2.2e-14 53.8 0.4 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 KII62192.1 - 2.3e-09 36.9 0.5 4.9e-07 29.2 0.3 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_2 PF00890.24 KII62192.1 - 3e-06 26.6 0.6 6.4e-06 25.5 0.4 1.6 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 KII62192.1 - 3.6e-05 23.0 0.5 0.013 14.5 0.1 2.8 2 1 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 KII62192.1 - 0.00054 20.1 0.5 0.0025 18.0 0.5 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 KII62192.1 - 0.0012 18.8 0.4 0.0023 17.8 0.4 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 KII62192.1 - 0.0016 17.8 1.0 0.0025 17.1 0.3 1.7 2 0 0 2 2 2 1 FAD binding domain UDPG_MGDP_dh_N PF03721.14 KII62192.1 - 0.0016 18.1 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.14 KII62192.1 - 0.0057 15.4 0.4 0.01 14.6 0.4 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 KII62192.1 - 0.008 15.4 0.6 0.024 13.9 0.4 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KII62192.1 - 0.01 15.5 0.2 0.019 14.6 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 KII62192.1 - 0.019 14.9 0.1 0.033 14.2 0.1 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_3 PF13738.6 KII62192.1 - 0.051 12.8 0.1 1.4 8.1 0.2 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KII62192.1 - 0.065 12.3 0.8 0.099 11.7 0.8 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 KII62192.1 - 0.1 13.2 0.3 0.46 11.1 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 KII62192.1 - 0.12 12.6 0.1 0.29 11.4 0.0 1.7 2 0 0 2 2 1 0 TrkA-N domain Shikimate_DH PF01488.20 KII62192.1 - 0.12 12.4 0.2 0.26 11.3 0.2 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 KII62192.1 - 0.13 12.2 0.8 0.57 10.2 0.1 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding tRNA-synt_1g PF09334.11 KII62193.1 - 4.4e-48 164.0 0.0 6.1e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) zf-C2H2_jaz PF12171.8 KII62193.1 - 1.6 9.1 6.3 5 7.5 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF2797 PF10977.8 KII62193.1 - 4.9 7.0 6.4 12 5.8 6.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) zf-MYND PF01753.18 KII62193.1 - 5.3 7.2 10.7 0.5 10.5 4.3 2.3 2 0 0 2 2 2 0 MYND finger Cupin_2 PF07883.11 KII62194.1 - 8.7e-13 47.8 0.1 1.2e-12 47.3 0.1 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 KII62194.1 - 0.00055 19.8 0.1 0.00072 19.5 0.1 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain CENP-C_C PF11699.8 KII62194.1 - 0.0045 17.2 0.0 0.0055 16.9 0.0 1.1 1 0 0 1 1 1 1 Mif2/CENP-C like Glyco_hydro_16 PF00722.21 KII62194.1 - 0.019 14.5 0.7 0.023 14.1 0.7 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 16 Cupin_3 PF05899.12 KII62194.1 - 0.045 13.4 0.0 0.061 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 KII62194.1 - 0.084 12.8 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Cupin_1 PF00190.22 KII62194.1 - 0.13 11.9 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Cupin LysR_substrate PF03466.20 KII62195.1 - 7.3e-31 107.2 0.0 9e-31 106.9 0.0 1.0 1 0 0 1 1 1 1 LysR substrate binding domain EamA PF00892.20 KII62196.1 - 5.8e-33 114.0 41.6 3.2e-18 66.2 16.9 2.0 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.6 KII62196.1 - 0.00062 19.4 11.2 0.00062 19.4 11.2 1.6 1 1 0 1 1 1 1 Putative multidrug resistance efflux transporter NADH-u_ox-rdase PF10785.9 KII62196.1 - 0.16 12.7 6.8 0.056 14.1 2.0 2.8 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Nuc_sug_transp PF04142.15 KII62196.1 - 0.68 9.0 6.8 0.38 9.9 1.0 2.4 2 1 0 2 2 2 0 Nucleotide-sugar transporter DUF2070 PF09843.9 KII62196.1 - 0.7 8.1 19.6 0.0056 15.0 6.9 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) Multi_Drug_Res PF00893.19 KII62196.1 - 0.91 10.2 9.7 0.078 13.7 2.8 2.8 2 1 0 2 2 2 0 Small Multidrug Resistance protein TMEM234 PF10639.9 KII62196.1 - 1.3 9.1 8.2 0.83 9.7 2.7 2.9 2 1 0 2 2 2 0 Putative transmembrane family 234 LysR_substrate PF03466.20 KII62197.1 - 2.2e-27 95.8 0.1 3.3e-27 95.2 0.1 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 KII62197.1 - 4.5e-15 55.3 0.1 7.2e-15 54.7 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 KII62197.1 - 0.17 11.7 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DNA_binding_1 PF01035.20 KII62198.1 - 6.5e-28 96.7 0.0 1.1e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.15 KII62198.1 - 0.0078 17.0 0.0 0.012 16.4 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain DUF572 PF04502.13 KII62199.1 - 5.1e-76 256.4 15.5 1.1e-75 255.4 15.0 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF572) zf-FCS PF06467.14 KII62199.1 - 0.011 15.6 0.5 0.16 11.9 0.1 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Hom_end_hint PF05203.16 KII62199.1 - 0.2 11.6 2.0 2.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Hom_end-associated Hint zf_UBZ PF18439.1 KII62199.1 - 0.25 11.0 1.9 1.1 8.9 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 KII62199.1 - 0.37 10.3 3.6 0.26 10.8 0.4 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding zf-ACC PF17848.1 KII62199.1 - 4.6 7.4 6.7 26 5.0 0.5 3.2 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain TMPIT PF07851.13 KII62199.1 - 5.7 6.1 5.5 7.8 5.6 5.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein KTI12 PF08433.10 KII62203.1 - 1.3e-17 64.2 0.4 1.6e-17 63.9 0.4 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 ATPase_2 PF01637.18 KII62203.1 - 5.9e-05 23.1 3.0 0.0048 16.8 0.3 3.0 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA PF00004.29 KII62203.1 - 0.0001 22.7 0.0 0.0002 21.8 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KII62203.1 - 0.0003 21.3 0.0 0.001 19.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KII62203.1 - 0.00067 19.7 0.0 0.0023 18.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KII62203.1 - 0.00087 19.1 0.0 0.0087 15.8 0.0 2.6 3 1 0 3 3 3 1 IstB-like ATP binding protein AAA_22 PF13401.6 KII62203.1 - 0.0028 17.9 0.1 0.021 15.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain CLP1_P PF16575.5 KII62203.1 - 0.0059 16.4 0.0 0.028 14.2 0.0 2.0 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_33 PF13671.6 KII62203.1 - 0.042 14.0 0.0 0.089 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KII62203.1 - 0.081 13.3 0.3 0.92 9.9 0.2 2.3 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 KII62203.1 - 0.088 13.2 0.0 0.33 11.4 0.0 2.1 2 0 0 2 2 2 0 RNA helicase RT_RNaseH PF17917.1 KII62204.1 - 4.9e-35 120.0 0.0 1.1e-34 118.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII62204.1 - 1e-31 108.9 0.0 2.1e-31 107.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII62204.1 - 1e-30 107.0 0.1 2.1e-30 105.9 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 KII62204.1 - 1e-07 31.8 0.4 2.2e-07 30.7 0.4 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.26 KII62204.1 - 2.7e-05 24.3 0.0 0.0014 18.8 0.0 2.6 1 1 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII62204.1 - 5.7e-05 23.4 0.0 0.00014 22.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 KII62204.1 - 0.0002 21.3 13.9 0.0013 18.8 3.6 2.9 2 0 0 2 2 2 2 Zinc knuckle rve_3 PF13683.6 KII62204.1 - 0.00031 20.4 0.4 0.0013 18.4 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain Asp_protease_2 PF13650.6 KII62204.1 - 0.00048 20.7 0.0 0.00094 19.8 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII62204.1 - 0.0025 18.3 0.0 0.0053 17.3 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC_3 PF13917.6 KII62204.1 - 0.023 14.7 11.6 1.4 9.0 11.6 2.5 1 1 0 1 1 1 0 Zinc knuckle Peptidase_A2E PF12382.8 KII62204.1 - 0.066 13.2 0.1 0.2 11.7 0.1 1.8 1 0 0 1 1 1 0 Retrotransposon peptidase HypA PF01155.19 KII62204.1 - 0.11 12.5 2.1 0.25 11.4 2.1 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Asp_protease PF09668.10 KII62204.1 - 0.16 11.7 0.0 0.45 10.3 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.6 KII62204.1 - 0.57 10.0 7.8 2.7 7.8 1.6 2.7 2 0 0 2 2 2 0 Zinc knuckle zinc-ribbons_6 PF07191.12 KII62204.1 - 2.9 7.9 7.8 7.4 6.6 7.8 1.7 1 0 0 1 1 1 0 zinc-ribbons rve PF00665.26 KII62205.1 - 8.4e-21 74.4 0.0 1.3e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII62205.1 - 2.6e-05 23.9 0.0 6.5e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII62205.1 - 0.064 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain P4Ha_N PF08336.11 KII62205.1 - 0.14 12.2 0.1 4.6 7.3 0.0 2.6 1 1 1 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Phage_lambda_P PF06992.11 KII62205.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Replication protein P Phage_int_SAM_6 PF18644.1 KII62207.1 - 0.058 13.4 0.2 0.1 12.6 0.2 1.4 1 0 0 1 1 1 0 Phage integrase SAM-like domain Sortilin-Vps10 PF15902.5 KII62208.1 - 1.2e-06 27.7 1.5 0.00089 18.2 0.6 2.5 1 1 1 3 3 3 3 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII62208.1 - 0.0048 16.7 2.6 5.6 7.4 0.0 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat NERD PF08378.11 KII62208.1 - 0.15 12.5 1.0 0.48 10.9 0.8 2.0 1 1 1 2 2 2 0 Nuclease-related domain Lipocalin_2 PF08212.12 KII62211.1 - 0.015 15.2 0.1 0.046 13.7 0.0 1.7 2 0 0 2 2 2 0 Lipocalin-like domain Kelch_6 PF13964.6 KII62214.1 - 1.2e-08 34.9 4.3 0.021 15.1 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII62214.1 - 0.028 14.7 0.5 33 4.9 0.1 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_4 PF13418.6 KII62214.1 - 0.056 13.5 0.2 6.5 6.8 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_1 PF01344.25 KII62214.1 - 0.15 11.6 7.9 6.7 6.4 0.0 4.2 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 KII62215.1 - 1.2e-06 28.0 0.1 0.0011 18.5 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII62215.1 - 1.3e-06 28.3 0.2 0.036 14.1 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KII62215.1 - 3e-05 24.1 0.4 0.051 13.9 0.0 2.3 1 1 1 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII62215.1 - 0.00087 19.2 0.2 0.088 12.8 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 KII62215.1 - 0.095 13.0 0.1 6 7.3 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 KII62216.1 - 4e-15 55.5 8.6 2.3e-05 24.5 0.2 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII62216.1 - 1.4e-13 50.2 10.8 3.3e-06 26.6 0.1 3.3 3 1 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII62216.1 - 3.6e-13 49.4 4.5 0.005 17.1 0.0 3.2 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII62216.1 - 5.4e-11 42.3 4.3 5.9e-05 23.0 0.0 3.4 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII62216.1 - 2.8e-09 36.6 8.2 8.2e-05 22.4 0.1 3.6 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII62216.1 - 5.9e-07 29.3 4.4 0.022 14.8 0.6 3.3 3 0 0 3 3 3 3 Kelch motif Med26 PF08711.11 KII62217.1 - 8.2e-10 38.6 1.0 1.4e-09 37.8 1.0 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Pkinase PF00069.25 KII62218.1 - 1.4e-13 50.8 0.2 9.9e-06 25.1 0.1 2.5 2 0 0 2 2 2 2 Protein kinase domain HEAT PF02985.22 KII62218.1 - 7.3e-10 38.3 0.1 0.0051 17.0 0.0 5.0 4 0 0 4 4 4 3 HEAT repeat WD40 PF00400.32 KII62218.1 - 2e-08 34.8 2.3 0.25 12.3 0.0 5.6 5 1 0 5 5 5 2 WD domain, G-beta repeat CLASP_N PF12348.8 KII62218.1 - 0.0044 16.6 4.9 0.014 15.0 0.0 3.4 4 0 0 4 4 4 1 CLASP N terminal Pkinase_Tyr PF07714.17 KII62218.1 - 0.0067 15.7 0.0 0.043 13.1 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase zf-UBR PF02207.20 KII62220.1 - 0.078 13.2 2.4 2.8 8.2 1.4 2.1 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) rve PF00665.26 KII62223.1 - 3.2e-10 40.2 0.0 3.8e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain Gb3_synth PF04572.12 KII62223.1 - 0.055 13.6 0.0 0.06 13.5 0.0 1.3 1 0 0 1 1 1 0 Alpha 1,4-glycosyltransferase conserved region RVT_1 PF00078.27 KII62226.1 - 0.087 12.3 0.0 0.15 11.5 0.0 1.3 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Transcrip_reg PF01709.20 KII62232.1 - 3.3e-31 108.5 1.1 3.9e-31 108.3 1.1 1.0 1 0 0 1 1 1 1 Transcriptional regulator Ribosomal_S8e PF01201.22 KII62232.1 - 0.15 12.3 1.0 21 5.3 0.5 2.5 2 1 1 3 3 3 0 Ribosomal protein S8e DUF4537 PF15057.6 KII62233.1 - 3.7e-09 36.7 1.3 0.00049 20.1 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4537) Tudor_2 PF18104.1 KII62233.1 - 0.001 18.7 1.1 0.94 9.2 0.0 2.7 2 0 0 2 2 2 2 Jumonji domain-containing protein 2A Tudor domain DUF2790 PF10976.8 KII62235.1 - 0.05 13.6 0.0 0.057 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2790) DUF3794 PF12673.7 KII62235.1 - 0.053 13.8 0.1 0.073 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3794) VPS13_C PF16909.5 KII62236.1 - 2.7e-32 112.0 10.6 4e-27 95.1 1.4 2.4 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Adeno_E4_34 PF04528.13 KII62236.1 - 0.0055 16.6 0.0 0.019 14.8 0.0 2.0 1 0 0 1 1 1 1 Adenovirus early E4 34 kDa protein conserved region ATG_C PF09333.11 KII62236.1 - 0.18 12.2 0.0 0.39 11.1 0.0 1.5 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain E1_DerP2_DerF2 PF02221.15 KII62237.1 - 2.1e-08 34.7 0.5 2.5e-08 34.4 0.5 1.1 1 0 0 1 1 1 1 ML domain VMR2 PF17055.5 KII62238.1 - 0.032 14.0 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Viral matrix protein M2 Sortilin_C PF15901.5 KII62241.1 - 4.4e-13 49.9 0.8 4.4e-13 49.9 0.8 1.6 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII62241.1 - 2e-12 46.7 5.2 5.5e-07 28.7 0.8 2.1 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII62241.1 - 0.02 14.8 8.5 12 6.4 0.0 4.0 4 0 0 4 4 4 0 BNR/Asp-box repeat DUF3825 PF12873.7 KII62241.1 - 0.077 12.4 0.9 0.14 11.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3825) Serpin PF00079.20 KII62243.1 - 1.7e-43 149.4 3.2 1.8e-43 149.3 3.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Transglut_core PF01841.19 KII62246.1 - 1.8e-09 38.0 0.1 0.0025 18.3 0.0 2.5 2 0 0 2 2 2 2 Transglutaminase-like superfamily RNase_E_G PF10150.9 KII62246.1 - 0.083 12.3 2.5 0.074 12.5 0.6 1.9 2 0 0 2 2 2 0 Ribonuclease E/G family AAA PF00004.29 KII62248.1 - 4.7e-13 49.7 0.0 1.5e-12 48.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 KII62248.1 - 2.3e-06 27.5 1.3 2e-05 24.5 0.0 2.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit BRCT PF00533.26 KII62248.1 - 1.4e-05 25.4 0.4 4.6e-05 23.7 0.1 2.1 2 0 0 2 2 1 1 BRCA1 C Terminus (BRCT) domain AAA_14 PF13173.6 KII62248.1 - 3.5e-05 23.8 1.8 0.00017 21.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KII62248.1 - 5.8e-05 23.4 1.5 0.00018 21.8 0.0 2.5 2 1 0 2 2 2 1 RNA helicase Rad17 PF03215.15 KII62248.1 - 7.1e-05 22.8 5.5 0.00019 21.4 0.2 3.5 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_22 PF13401.6 KII62248.1 - 0.00057 20.2 0.2 1.7 8.9 0.1 2.8 1 1 1 2 2 2 2 AAA domain AAA_assoc_2 PF16193.5 KII62248.1 - 0.0036 17.6 0.1 0.015 15.6 0.0 2.1 2 0 0 2 2 1 1 AAA C-terminal domain RuvB_N PF05496.12 KII62248.1 - 0.0039 17.0 0.0 0.011 15.5 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KII62248.1 - 0.0048 17.3 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain BRCT_2 PF16589.5 KII62248.1 - 0.0063 16.9 0.3 0.69 10.4 0.1 2.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain AAA_33 PF13671.6 KII62248.1 - 0.0092 16.2 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain RAMP4 PF06624.12 KII62248.1 - 0.028 14.5 1.5 0.055 13.5 0.2 2.1 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 NTPase_1 PF03266.15 KII62248.1 - 0.048 13.6 0.3 0.71 9.8 0.0 2.5 1 1 1 2 2 2 0 NTPase Zeta_toxin PF06414.12 KII62248.1 - 0.053 12.8 0.0 0.13 11.5 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin Sigma54_activ_2 PF14532.6 KII62248.1 - 0.055 13.6 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_17 PF13207.6 KII62248.1 - 0.071 13.5 0.6 0.19 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain DDE_3 PF13358.6 KII62249.1 - 1.5e-05 24.8 0.0 1.8e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Diphthamide_syn PF01866.17 KII62249.1 - 0.033 13.7 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 Putative diphthamide synthesis protein Velvet PF11754.8 KII62250.1 - 0.065 13.2 0.2 0.082 12.8 0.1 1.3 1 1 0 1 1 1 0 Velvet factor Hydrolase_4 PF12146.8 KII62251.1 - 6.1e-08 32.2 0.0 0.00025 20.4 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KII62251.1 - 4.1e-07 29.9 0.1 0.00021 21.0 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KII62251.1 - 4.8e-06 26.2 0.0 0.0011 18.5 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 KII62251.1 - 0.00022 21.9 0.0 0.00077 20.1 0.0 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF818 PF05677.12 KII62251.1 - 0.00083 18.4 0.1 0.0013 17.8 0.1 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_2 PF02230.16 KII62251.1 - 0.0019 18.1 0.2 0.0072 16.2 0.2 1.8 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase LIP PF03583.14 KII62251.1 - 0.0096 15.3 0.0 1.2 8.4 0.0 2.2 2 0 0 2 2 2 1 Secretory lipase DLH PF01738.18 KII62251.1 - 0.018 14.6 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF1057 PF06342.12 KII62251.1 - 0.024 13.7 0.1 0.035 13.2 0.1 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) FSH1 PF03959.13 KII62251.1 - 0.044 13.4 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 KII62251.1 - 0.052 13.1 0.0 0.3 10.7 0.0 1.9 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 KII62251.1 - 0.13 12.1 0.2 0.26 11.1 0.2 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold UPF0227 PF05728.12 KII62251.1 - 0.13 12.2 0.0 17 5.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Esterase PF00756.20 KII62251.1 - 0.19 11.3 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative esterase BAAT_C PF08840.11 KII62251.1 - 0.2 11.5 0.1 3.2 7.6 0.1 2.1 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal AXE1 PF05448.12 KII62251.1 - 0.22 10.1 0.1 0.85 8.2 0.0 1.8 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) AF2331-like PF14556.6 KII62252.1 - 0.048 14.2 0.0 0.68 10.5 0.1 2.2 2 0 0 2 2 2 0 AF2331-like PDZ PF00595.24 KII62254.1 - 3e-16 59.5 1.8 8.6e-16 58.1 1.8 1.6 1 1 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII62254.1 - 7.1e-07 29.0 1.4 3.5e-06 26.8 1.4 2.0 1 1 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII62254.1 - 0.0066 16.8 0.5 0.01 16.1 0.5 1.4 1 1 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KII62254.1 - 0.016 15.2 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain PDZ PF00595.24 KII62255.1 - 2.3e-22 79.1 0.3 5.6e-11 42.6 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KII62255.1 - 5.4e-15 55.0 0.0 4e-06 26.6 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KII62255.1 - 1.1e-14 54.5 0.0 6.4e-06 26.4 0.0 2.7 2 0 0 2 2 2 2 PDZ domain ZU5 PF00791.20 KII62255.1 - 1.4e-09 38.2 0.0 6.6e-09 36.0 0.0 2.1 2 0 0 2 2 2 1 ZU5 domain Guanylate_kin PF00625.21 KII62255.1 - 3.9e-06 26.7 0.1 1.1e-05 25.2 0.1 1.8 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.17 KII62255.1 - 0.00047 19.8 0.0 0.001 18.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Tricorn_PDZ PF14685.6 KII62255.1 - 0.0033 17.3 0.0 0.98 9.4 0.0 2.5 2 0 0 2 2 2 2 Tricorn protease PDZ domain SH3_9 PF14604.6 KII62255.1 - 0.02 14.8 0.0 0.047 13.6 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain RHH_3 PF12651.7 KII62256.1 - 0.021 14.8 0.0 0.061 13.3 0.0 1.7 1 1 0 1 1 1 0 Ribbon-helix-helix domain HTH_Tnp_Tc5 PF03221.16 KII62259.1 - 8.3e-05 22.5 0.1 0.00013 21.9 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 KII62259.1 - 0.03 14.1 0.6 1.8 8.4 0.0 2.5 2 0 0 2 2 2 0 Homeodomain-like domain ABC_tran PF00005.27 KII62259.1 - 0.03 14.8 0.0 0.039 14.4 0.0 1.4 1 1 0 1 1 1 0 ABC transporter LacI PF00356.21 KII62259.1 - 0.053 13.3 0.0 0.082 12.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family DDE_1 PF03184.19 KII62259.1 - 0.13 11.9 0.5 0.32 10.6 0.1 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease Sortilin_C PF15901.5 KII62267.1 - 4.7e-11 43.3 2.0 6.8e-11 42.8 2.0 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII62267.1 - 0.0005 19.0 0.1 0.00061 18.7 0.1 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, YoeB_toxin PF06769.14 KII62268.1 - 0.0091 16.0 0.1 0.012 15.6 0.1 1.3 1 0 0 1 1 1 1 YoeB-like toxin of bacterial type II toxin-antitoxin system Kelch_4 PF13418.6 KII62269.1 - 2e-14 53.3 13.1 0.017 15.1 0.1 5.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 KII62269.1 - 2.5e-12 46.6 17.5 0.00039 20.6 0.1 5.9 6 1 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KII62269.1 - 7.3e-12 44.7 17.8 0.00016 21.2 0.8 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII62269.1 - 1e-08 35.0 9.0 0.0027 17.7 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 KII62269.1 - 5.7e-07 29.7 5.7 0.83 10.0 0.0 5.6 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII62269.1 - 1.5e-06 27.9 14.4 0.088 12.8 0.3 5.5 5 0 0 5 5 5 3 Kelch motif Hamartin PF04388.12 KII62272.1 - 0.066 11.9 1.2 0.063 11.9 1.2 1.0 1 0 0 1 1 1 0 Hamartin protein RT_RNaseH_2 PF17919.1 KII62275.1 - 8.6e-20 70.6 0.0 1.6e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII62275.1 - 8.3e-11 42.1 0.0 1.5e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII62276.1 - 1.1e-08 34.9 0.0 2.6e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII62276.1 - 0.013 15.6 6.1 0.013 15.6 6.1 2.4 2 0 0 2 2 2 0 Zinc knuckle HypA PF01155.19 KII62276.1 - 0.037 14.1 3.2 0.11 12.5 3.2 1.8 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SprA-related PF12118.8 KII62278.1 - 0.17 11.0 7.5 0.22 10.6 7.5 1.3 1 0 0 1 1 1 0 SprA-related family rve PF00665.26 KII62279.1 - 1.4e-18 67.2 0.0 2.4e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII62279.1 - 0.00024 20.8 0.1 0.00054 19.7 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain FLYWCH PF04500.16 KII62285.1 - 1.4e-10 41.2 0.3 2.8e-10 40.1 0.3 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII62285.1 - 0.00059 20.2 0.1 0.0025 18.2 0.1 2.1 2 1 0 2 2 2 1 MULE transposase domain AcetylCoA_hyd_C PF13336.6 KII62286.1 - 1.1e-61 207.3 0.1 1.9e-61 206.5 0.1 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.15 KII62286.1 - 7.2e-25 88.1 0.0 1.4e-24 87.2 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain PliI PF16743.5 KII62286.1 - 0.083 12.6 0.2 0.17 11.6 0.2 1.4 1 0 0 1 1 1 0 Periplasmic lysozyme inhibitor of I-type lysozyme CoA_trans PF01144.23 KII62286.1 - 0.19 11.1 0.7 7.7 5.8 0.0 2.7 3 0 0 3 3 3 0 Coenzyme A transferase MAD PF05557.13 KII62289.1 - 6.4e-15 54.6 49.8 1e-11 44.0 1.7 3.8 2 1 1 3 3 3 2 Mitotic checkpoint protein DHR10 PF18595.1 KII62289.1 - 0.0025 17.9 8.6 0.0025 17.9 8.6 5.0 3 2 2 5 5 5 2 Designed helical repeat protein 10 domain APG6_N PF17675.1 KII62289.1 - 0.015 15.8 1.7 0.015 15.8 1.7 4.4 2 1 1 4 4 4 0 Apg6 coiled-coil region TSC22 PF01166.18 KII62289.1 - 0.015 15.6 0.3 0.015 15.6 0.3 5.1 4 1 1 5 5 5 0 TSC-22/dip/bun family Peptidase_C71 PF12386.8 KII62289.1 - 0.17 11.5 2.0 0.26 10.9 0.1 2.2 2 0 0 2 2 2 0 Pseudomurein endo-isopeptidase Pei HALZ PF02183.18 KII62289.1 - 8.7 6.7 22.9 0.89 9.8 1.6 4.9 4 1 1 5 5 5 0 Homeobox associated leucine zipper Peptidase_M1 PF01433.20 KII62291.1 - 3.2e-68 229.6 0.4 5.7e-68 228.7 0.4 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KII62291.1 - 1.4e-40 139.8 0.0 1.8e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain IstB_IS21_ATP PF08483.11 KII62291.1 - 0.0032 17.3 0.4 0.0062 16.4 0.4 1.5 1 0 0 1 1 1 1 IstB-like ATP binding N-terminal DUF4506 PF14958.6 KII62292.1 - 0.023 14.2 0.0 0.027 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4506) Glycogen_syn PF05693.13 KII62293.1 - 4.8e-235 782.0 0.4 1.1e-234 780.8 0.2 1.6 1 1 1 2 2 2 1 Glycogen synthase Glycos_transf_1 PF00534.20 KII62293.1 - 0.0002 20.9 0.0 0.0085 15.6 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KII62293.1 - 0.006 16.6 0.1 0.025 14.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 KII62293.1 - 0.013 16.0 0.0 0.9 10.0 0.0 2.6 3 0 0 3 3 3 0 Glycosyl transferases group 1 NADH-UOR_E PF16514.5 KII62293.1 - 0.15 12.4 0.1 0.4 11.0 0.1 1.7 1 0 0 1 1 1 0 putative NADH-ubiquinone oxidoreductase chain E DDE_3 PF13358.6 KII62294.1 - 3.3e-05 23.7 0.0 0.019 14.8 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_3 PF13358.6 KII62296.1 - 2.9e-12 46.6 0.0 5e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Baculo_p24 PF05073.12 KII62297.1 - 0.012 15.4 0.8 0.069 12.9 0.1 1.9 2 0 0 2 2 2 0 Baculovirus P24 capsid protein Fib_alpha PF08702.10 KII62297.1 - 0.32 11.2 3.4 0.46 10.7 3.4 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family LIM PF00412.22 KII62298.1 - 9.5e-29 99.4 58.1 8.8e-14 51.5 5.9 6.2 5 1 1 6 6 6 4 LIM domain zf-RRN7 PF11781.8 KII62298.1 - 0.0021 17.7 0.4 0.0021 17.7 0.4 4.4 6 0 0 6 6 6 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 FUR PF01475.19 KII62298.1 - 0.69 10.1 6.7 0.93 9.6 4.9 2.1 1 1 1 2 2 2 0 Ferric uptake regulator family zf-C3HC4_2 PF13923.6 KII62300.1 - 7e-11 41.8 10.5 1.1e-10 41.1 10.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KII62300.1 - 1.3e-09 37.8 7.7 2e-09 37.2 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII62300.1 - 2.2e-09 37.5 10.4 3.8e-09 36.7 10.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KII62300.1 - 7.8e-09 35.3 9.5 1.3e-08 34.5 9.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII62300.1 - 6.3e-07 29.1 10.6 1.2e-05 25.0 11.1 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KII62300.1 - 1.2e-06 28.3 5.7 2.1e-06 27.6 5.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KII62300.1 - 2.7e-06 27.3 11.3 5.7e-06 26.2 11.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KII62300.1 - 4.1e-06 27.0 4.9 4.1e-06 27.0 4.9 1.8 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KII62300.1 - 0.0007 19.6 2.6 0.0013 18.7 2.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 KII62300.1 - 0.006 16.7 3.3 0.013 15.6 3.3 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 KII62300.1 - 0.0072 16.5 10.0 0.0072 16.5 10.0 2.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 KII62300.1 - 0.01 15.7 4.1 0.022 14.6 4.1 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 KII62300.1 - 0.19 11.4 4.7 0.31 10.7 4.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KII62300.1 - 1.3 8.8 6.7 3.3 7.5 6.7 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.8 KII62300.1 - 1.4 8.8 8.0 2.9 7.8 8.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit NUP214 PF16755.5 KII62302.1 - 0.00015 21.1 2.0 0.00018 20.9 2.0 1.2 1 0 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Sortilin-Vps10 PF15902.5 KII62303.1 - 0.0013 17.7 0.0 0.002 17.0 0.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, DUF5099 PF17025.5 KII62303.1 - 0.013 15.9 0.5 0.028 14.8 0.1 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5099) Serpin PF00079.20 KII62305.1 - 1.2e-48 166.3 1.8 1.3e-48 166.2 1.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII62306.1 - 5.6e-24 85.1 0.4 6.8e-24 84.9 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.26 KII62308.1 - 1.4e-24 86.5 0.0 2e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII62308.1 - 1.3e-21 76.5 0.1 2.3e-21 75.6 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII62308.1 - 1e-06 28.9 0.1 4.7e-06 26.7 0.0 2.2 3 0 0 3 3 3 1 H2C2 zinc finger rve_3 PF13683.6 KII62308.1 - 0.0063 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII62308.1 - 0.04 14.1 0.0 0.073 13.3 0.0 1.3 1 0 0 1 1 1 0 DDE domain Serpin PF00079.20 KII62310.1 - 1e-07 31.7 0.1 1.2e-07 31.4 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) MULE PF10551.9 KII62311.1 - 0.018 15.4 0.2 6.2 7.3 0.0 2.5 2 0 0 2 2 2 0 MULE transposase domain F-box PF00646.33 KII62311.1 - 0.12 12.3 0.9 0.2 11.5 0.1 1.8 2 0 0 2 2 2 0 F-box domain MLVIN_C PF18697.1 KII62313.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.6 2 0 0 2 2 2 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Homeodomain PF00046.29 KII62318.1 - 2.5e-06 27.2 0.7 4.7e-06 26.4 0.1 1.8 2 0 0 2 2 2 1 Homeodomain HTH_23 PF13384.6 KII62320.1 - 1.2e-07 31.3 0.0 1.3e-06 28.0 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.18 KII62320.1 - 4e-06 26.8 0.0 4.6e-06 26.6 0.0 1.0 1 0 0 1 1 1 1 'Paired box' domain HTH_24 PF13412.6 KII62320.1 - 4.4e-06 26.2 0.8 0.00016 21.2 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_32 PF13565.6 KII62320.1 - 7.5e-06 26.5 0.0 0.00011 22.8 0.0 2.0 1 1 1 2 2 2 1 Homeodomain-like domain MarR_2 PF12802.7 KII62320.1 - 2.9e-05 23.9 0.0 5.9e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 MarR family HTH_38 PF13936.6 KII62320.1 - 6.8e-05 22.5 0.1 0.00023 20.8 0.1 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4 PF04545.16 KII62320.1 - 8.8e-05 22.0 0.1 0.00022 20.7 0.0 1.7 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.6 KII62320.1 - 0.00013 21.4 0.0 0.00043 19.6 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 CENP-B_N PF04218.13 KII62320.1 - 0.00013 21.6 0.0 0.00029 20.4 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain TrmB PF01978.19 KII62320.1 - 0.00057 19.7 0.0 0.0014 18.5 0.0 1.6 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.6 KII62320.1 - 0.00072 19.6 0.0 0.0056 16.8 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain Fe_dep_repress PF01325.19 KII62320.1 - 0.0015 18.7 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_29 PF13551.6 KII62320.1 - 0.002 18.1 0.0 0.0043 17.1 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn helix HTH_Tnp_1 PF01527.20 KII62320.1 - 0.0026 18.0 0.1 0.0049 17.2 0.1 1.6 1 1 0 1 1 1 1 Transposase HTH_IclR PF09339.10 KII62320.1 - 0.0029 17.4 0.0 0.053 13.3 0.0 2.2 2 0 0 2 2 2 1 IclR helix-turn-helix domain LacI PF00356.21 KII62320.1 - 0.0038 17.0 0.6 0.078 12.8 0.2 2.8 2 1 1 3 3 3 1 Bacterial regulatory proteins, lacI family HTH_3 PF01381.22 KII62320.1 - 0.0067 16.5 0.1 0.045 13.8 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix Phage_CI_repr PF07022.13 KII62320.1 - 0.0068 16.5 0.0 0.0097 16.0 0.0 1.3 1 1 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain HTH_27 PF13463.6 KII62320.1 - 0.016 15.7 0.1 0.028 14.9 0.0 1.6 2 0 0 2 2 1 0 Winged helix DNA-binding domain Sigma70_r4_2 PF08281.12 KII62320.1 - 0.017 14.8 0.0 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 DUF1670 PF07900.11 KII62320.1 - 0.019 14.3 0.2 0.022 14.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1670) OCRL_clath_bd PF16726.5 KII62320.1 - 0.022 14.9 0.6 0.026 14.7 0.6 1.1 1 0 0 1 1 1 0 Inositol polyphosphate 5-phosphatase clathrin binding domain HTH_1 PF00126.27 KII62320.1 - 0.023 14.6 0.8 0.084 12.8 0.0 2.3 3 0 0 3 3 3 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_40 PF14493.6 KII62320.1 - 0.031 14.7 0.7 0.037 14.5 0.7 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_50 PF18024.1 KII62320.1 - 0.036 13.7 0.0 0.089 12.4 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII62320.1 - 0.055 13.7 0.6 0.75 10.1 0.1 2.2 2 0 0 2 2 2 0 Transposase TnsD PF15978.5 KII62320.1 - 0.055 12.5 0.4 0.086 11.8 0.4 1.4 1 1 0 1 1 1 0 Tn7-like transposition protein D MarR PF01047.22 KII62320.1 - 0.064 13.2 0.1 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 MarR family Bot1p PF12298.8 KII62320.1 - 0.076 13.2 0.8 2.9 8.1 0.1 2.0 1 1 1 2 2 2 0 Eukaryotic mitochondrial regulator protein HTH_Crp_2 PF13545.6 KII62320.1 - 0.082 12.9 0.2 0.15 12.1 0.1 1.4 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain Phage_terminase PF10668.9 KII62320.1 - 0.16 12.0 0.1 0.87 9.6 0.0 2.0 2 0 0 2 2 2 0 Phage terminase small subunit PK PF00224.21 KII62321.1 - 7e-100 334.3 3.0 8.7e-100 334.0 3.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KII62321.1 - 1.4e-26 93.0 0.0 1.2e-25 90.0 0.0 2.3 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KII62321.1 - 4.9e-05 22.6 0.4 8.7e-05 21.8 0.4 1.3 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family DUF3127 PF11325.8 KII62321.1 - 0.065 13.5 0.1 0.27 11.5 0.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3127) NADH_4Fe-4S PF10589.9 KII62321.1 - 0.64 10.1 2.9 6.5 6.9 0.0 3.4 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region RT_RNaseH_2 PF17919.1 KII62323.1 - 1.6e-34 117.9 0.0 3.6e-34 116.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII62323.1 - 1.1e-28 99.6 0.0 2.3e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII62323.1 - 1.3e-23 83.7 0.0 2.4e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII62323.1 - 3.3e-05 24.4 0.0 7.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII62323.1 - 0.00037 21.1 0.0 0.00072 20.1 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII62323.1 - 0.13 12.6 0.0 0.5 10.7 0.0 2.0 1 1 0 1 1 1 0 Retroviral aspartyl protease rve PF00665.26 KII62324.1 - 5.1e-21 75.1 0.2 3.1e-20 72.5 0.0 1.9 1 1 1 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII62324.1 - 8e-06 25.5 0.2 1.6e-05 24.6 0.2 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII62324.1 - 0.0057 16.7 0.7 0.014 15.5 0.7 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain MADF_DNA_bdg PF10545.9 KII62324.1 - 0.1 12.9 1.0 0.43 10.9 0.0 2.4 2 1 1 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like MCM PF00493.23 KII62325.1 - 6.4e-99 329.6 0.1 1.1e-98 328.8 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KII62325.1 - 2.9e-36 124.1 2.5 5.2e-36 123.3 2.5 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KII62325.1 - 2.3e-26 92.0 0.4 2.3e-26 92.0 0.4 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 KII62325.1 - 2.7e-12 47.2 2.9 7.1e-12 45.8 2.9 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KII62325.1 - 8.8e-07 28.5 0.0 0.00012 21.5 0.0 2.4 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KII62325.1 - 1.2e-05 25.4 0.0 2.3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KII62325.1 - 0.0069 16.1 0.1 0.039 13.7 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 KII62325.1 - 0.017 15.0 0.1 0.076 12.9 0.0 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 KII62325.1 - 0.12 12.8 0.2 0.36 11.3 0.2 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DDE_1 PF03184.19 KII62327.1 - 3e-11 43.3 0.0 5.9e-11 42.3 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII62328.1 - 0.00024 20.9 0.0 0.00048 19.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Viral_DNA_Zn_bi PF03728.13 KII62328.1 - 0.016 15.8 1.8 0.036 14.6 0.4 2.0 1 1 1 2 2 2 0 Viral DNA-binding protein, zinc binding domain DDE_3 PF13358.6 KII62329.1 - 4.4e-07 29.8 0.0 5.3e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease ATE_C PF04377.15 KII62331.1 - 2.5e-32 112.3 5.5 2.5e-32 112.3 5.5 1.7 2 1 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 KII62331.1 - 3.4e-06 27.4 4.5 3.4e-06 27.4 4.5 2.1 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, N terminus Serpin PF00079.20 KII62334.1 - 7e-34 117.7 0.2 7.9e-34 117.6 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RT_RNaseH PF17917.1 KII62336.1 - 3.4e-08 33.7 0.3 9.8e-08 32.2 0.1 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII62336.1 - 0.025 14.6 0.1 0.058 13.4 0.1 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII62337.1 - 2.3e-11 43.6 0.0 3.3e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII62337.1 - 0.0077 16.5 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase ADK_lid PF05191.14 KII62338.1 - 0.0048 16.8 0.5 0.011 15.7 0.5 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid tRNA_synt_2f PF02092.17 KII62338.1 - 0.038 12.9 0.0 0.048 12.6 0.0 1.1 1 0 0 1 1 1 0 Glycyl-tRNA synthetase beta subunit Zn-ribbon_8 PF09723.10 KII62338.1 - 0.13 12.4 1.5 0.39 10.9 1.4 1.9 1 1 0 1 1 1 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 KII62338.1 - 0.86 9.4 5.2 11 5.9 5.2 2.2 1 1 0 1 1 1 0 Rubredoxin metal binding domain HTH_23 PF13384.6 KII62341.1 - 7.9e-05 22.3 0.5 0.0031 17.3 0.0 3.0 2 1 1 3 3 3 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.16 KII62341.1 - 0.00031 20.8 1.7 0.0052 16.8 1.7 2.1 1 1 0 1 1 1 1 Transposase HTH_Tnp_Tc3_2 PF01498.18 KII62341.1 - 0.00072 19.8 0.8 0.09 13.0 0.2 2.3 2 0 0 2 2 2 1 Transposase CENP-B_N PF04218.13 KII62341.1 - 0.0011 18.5 0.9 0.0049 16.5 0.1 2.3 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain GerE PF00196.19 KII62341.1 - 0.0017 17.9 0.9 0.0093 15.5 0.1 2.3 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family HTH_29 PF13551.6 KII62341.1 - 0.0022 18.0 0.1 0.017 15.1 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn helix HTH_11 PF08279.12 KII62341.1 - 0.015 15.3 0.7 0.27 11.2 0.0 2.6 3 0 0 3 3 3 0 HTH domain HTH_28 PF13518.6 KII62341.1 - 0.016 15.3 0.0 0.058 13.5 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain Diphtheria_R PF01324.19 KII62341.1 - 0.023 14.3 0.8 0.028 14.1 0.8 1.2 1 0 0 1 1 1 0 Diphtheria toxin, R domain BrkDBD PF09607.10 KII62341.1 - 0.024 14.4 0.1 0.054 13.3 0.1 1.6 1 0 0 1 1 1 0 Brinker DNA-binding domain DUF1804 PF08822.11 KII62341.1 - 0.027 14.5 0.0 0.038 14.0 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1804) HTH_7 PF02796.15 KII62341.1 - 0.034 14.2 0.5 0.21 11.7 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_10 PF04967.12 KII62341.1 - 0.036 13.9 0.1 0.17 11.7 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain HTH_33 PF13592.6 KII62341.1 - 0.054 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Arg_repressor PF01316.21 KII62341.1 - 0.073 12.8 0.2 0.14 11.9 0.2 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Terminase_5 PF06056.12 KII62341.1 - 0.15 12.0 0.4 0.48 10.4 0.0 2.1 3 0 0 3 3 3 0 Putative ATPase subunit of terminase (gpP-like) TrmB PF01978.19 KII62341.1 - 0.16 11.8 0.3 4.4 7.3 0.0 2.6 2 1 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB NUMOD1 PF07453.13 KII62341.1 - 0.19 12.0 1.6 0.28 11.5 0.1 2.1 3 0 0 3 3 2 0 NUMOD1 domain Serpin PF00079.20 KII62345.1 - 2.8e-44 152.0 2.9 3.1e-44 151.8 2.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.6 KII62346.1 - 0.029 13.8 0.3 0.1 12.0 0.2 1.7 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP Sid-5 PF17204.3 KII62347.1 - 0.17 12.1 0.9 1.3 9.2 0.4 2.4 2 0 0 2 2 2 0 Sid-5 family DUF3290 PF11694.8 KII62347.1 - 1.4 8.9 9.3 0.43 10.5 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) DDE_3 PF13358.6 KII62348.1 - 4.2e-05 23.3 0.0 0.0001 22.1 0.0 1.5 1 1 1 2 2 2 1 DDE superfamily endonuclease Ribonuclease_P PF00825.18 KII62348.1 - 0.0079 16.3 0.0 0.009 16.1 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P Serpin PF00079.20 KII62349.1 - 6.8e-43 147.4 0.7 7.4e-43 147.3 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Glyco_hydro_38 PF18438.1 KII62349.1 - 0.0054 16.8 0.2 0.012 15.6 0.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain 1 GTA_TIM PF13547.6 KII62349.1 - 0.04 13.2 0.1 0.056 12.7 0.1 1.2 1 0 0 1 1 1 0 GTA TIM-barrel-like domain NAF PF03822.14 KII62350.1 - 0.32 11.2 1.7 0.75 10.0 1.7 1.6 1 1 0 1 1 1 0 NAF domain Hydrolase_like PF13242.6 KII62351.1 - 6.9e-17 61.3 0.0 4.7e-16 58.6 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 KII62351.1 - 6.9e-06 26.5 0.0 9.9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KII62351.1 - 0.00065 19.8 0.0 0.001 19.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 KII62351.1 - 0.042 13.5 0.0 0.094 12.3 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase HALZ PF02183.18 KII62351.1 - 0.49 10.6 1.6 31 4.9 0.1 2.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper TPR_1 PF00515.28 KII62353.1 - 1.6e-14 53.0 2.1 4.6e-07 29.4 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KII62353.1 - 1.3e-11 43.7 2.1 3.6e-05 23.5 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 KII62353.1 - 2.1e-09 37.8 0.1 1.7e-05 25.4 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII62353.1 - 2.7e-09 36.5 0.8 2e-06 27.5 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII62353.1 - 8e-05 22.8 0.6 0.045 14.0 0.2 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KII62353.1 - 8.1e-05 22.7 0.0 0.00018 21.6 0.0 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 KII62353.1 - 8.6e-05 23.0 0.0 0.0034 17.9 0.0 1.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KII62353.1 - 0.00014 21.5 2.1 0.56 9.9 0.0 3.1 1 1 2 3 3 3 2 TPR repeat TPR_14 PF13428.6 KII62353.1 - 0.0025 18.5 0.0 0.55 11.2 0.0 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KII62353.1 - 0.0038 17.4 0.4 0.0088 16.2 0.4 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KII62353.1 - 0.015 15.3 0.2 14 6.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ChAPs PF09295.10 KII62353.1 - 0.056 12.4 0.0 0.069 12.1 0.0 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) SCVP PF17619.2 KII62353.1 - 0.07 14.0 0.3 0.22 12.4 0.1 2.1 1 1 1 2 2 2 0 Secreted clade V proteins partial_CstF PF15861.5 KII62353.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain MIT PF04212.18 KII62353.1 - 0.55 10.3 4.2 11 6.2 0.1 3.2 2 2 2 4 4 4 0 MIT (microtubule interacting and transport) domain 14-3-3 PF00244.20 KII62355.1 - 2.1e-80 269.4 11.3 2.4e-80 269.2 11.3 1.0 1 0 0 1 1 1 1 14-3-3 protein Annexin PF00191.20 KII62356.1 - 1.6e-20 72.9 12.2 9.5e-09 35.2 0.5 3.7 4 0 0 4 4 4 3 Annexin DUF1765 PF08578.10 KII62356.1 - 1.3 9.5 6.8 0.87 10.1 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1765) Peptidase_S41_N PF11918.8 KII62357.1 - 0.066 13.4 0.4 0.22 11.7 0.0 2.0 2 1 0 2 2 2 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP PknG_TPR PF16918.5 KII62357.1 - 0.2 10.3 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat Atg14 PF10186.9 KII62361.1 - 0.025 13.7 0.8 0.026 13.6 0.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SPACA9 PF15120.6 KII62361.1 - 0.026 14.3 0.1 0.036 13.9 0.1 1.2 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 Cauli_AT PF03233.13 KII62361.1 - 0.041 13.8 1.7 0.056 13.4 1.7 1.2 1 0 0 1 1 1 0 Aphid transmission protein DUF3450 PF11932.8 KII62362.1 - 0.00018 20.9 3.6 0.00018 20.9 3.6 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 KII62362.1 - 0.0073 16.3 3.9 0.0073 16.3 3.9 2.2 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.8 KII62362.1 - 0.021 15.0 10.4 0.41 10.9 10.0 2.2 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ERM PF00769.19 KII62362.1 - 0.026 14.4 6.0 0.062 13.1 6.0 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Sec2p PF06428.11 KII62362.1 - 0.11 12.5 6.9 0.16 12.0 0.2 2.8 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p FlxA PF14282.6 KII62362.1 - 0.14 12.2 13.8 2.9 8.0 1.4 3.1 1 1 1 3 3 3 0 FlxA-like protein Atg14 PF10186.9 KII62362.1 - 0.28 10.2 7.4 0.38 9.8 7.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Csm1_N PF18504.1 KII62362.1 - 0.28 11.5 10.3 0.17 12.2 0.6 3.1 2 1 1 3 3 3 0 Csm1 N-terminal domain UPF0242 PF06785.11 KII62362.1 - 0.38 10.8 13.6 2.6 8.1 13.2 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus NRBF2 PF08961.10 KII62362.1 - 0.82 9.2 7.1 4.1 6.9 0.4 2.1 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator APG6_N PF17675.1 KII62362.1 - 1.8 9.1 9.7 0.6 10.6 3.7 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region YabA PF06156.13 KII62362.1 - 3.3 8.4 8.5 3.8 8.2 2.6 2.6 1 1 0 2 2 2 0 Initiation control protein YabA Noelin-1 PF12308.8 KII62362.1 - 6.4 6.8 7.8 1.9 8.5 1.4 2.3 1 1 1 2 2 2 0 Neurogenesis glycoprotein Gemin6 PF06372.12 KII62363.1 - 0.0058 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Gemin6 protein zf-UBR PF02207.20 KII62365.1 - 4.5e-10 39.5 9.2 6.3e-10 39.1 9.2 1.2 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-dskA_traR PF01258.17 KII62365.1 - 5.2 7.1 8.0 1.8 8.6 0.6 2.6 2 1 1 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger DUF4504 PF14953.6 KII62366.1 - 5.8e-05 22.6 3.0 0.00014 21.4 2.9 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4504) DUF2604 PF10790.9 KII62366.1 - 0.13 12.6 0.0 0.67 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein of Unknown function (DUF2604) DUF4928 PF16280.5 KII62367.1 - 0.011 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4928) Condensin2nSMC PF12422.8 KII62368.1 - 0.069 13.3 0.1 0.43 10.8 0.0 2.3 2 1 1 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit MerR_2 PF13591.6 KII62370.1 - 0.015 15.1 0.0 0.037 13.9 0.0 1.6 1 1 0 1 1 1 0 MerR HTH family regulatory protein EMG1 PF03587.14 KII62372.1 - 0.051 13.2 0.1 5.6 6.6 0.0 2.1 2 0 0 2 2 2 0 EMG1/NEP1 methyltransferase SNAP PF14938.6 KII62375.1 - 6.2e-11 42.3 5.5 8e-11 41.9 5.5 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_20 PF14561.6 KII62375.1 - 0.0052 17.1 0.0 0.015 15.6 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII62375.1 - 0.0095 16.2 0.6 0.11 12.9 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KII62375.1 - 0.04 14.1 3.5 4 7.8 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII62375.1 - 0.043 14.0 6.0 0.061 13.6 0.3 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII62375.1 - 0.34 10.8 3.6 21 5.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Sec16_C PF12931.7 KII62375.1 - 0.64 9.6 4.4 4.1 7.0 0.1 2.7 1 1 2 3 3 3 0 Sec23-binding domain of Sec16 SNAP PF14938.6 KII62376.1 - 1.8e-15 57.1 7.4 2.3e-15 56.8 7.4 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 KII62376.1 - 0.00044 20.7 0.6 7.9 7.4 0.1 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KII62376.1 - 0.0015 18.5 2.0 0.69 10.2 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII62376.1 - 0.0074 16.6 0.7 2.7 8.4 0.2 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII62376.1 - 0.009 16.2 0.9 0.009 16.2 0.9 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 KII62376.1 - 0.012 15.6 1.1 14 6.0 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KII62376.1 - 0.017 15.4 0.9 0.11 12.7 0.0 2.6 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 HTH_46 PF15977.5 KII62376.1 - 0.053 13.5 0.1 0.18 11.9 0.1 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA binding Curto_V2 PF07325.11 KII62376.1 - 0.08 12.8 0.3 0.08 12.8 0.3 2.9 3 0 0 3 3 3 0 Curtovirus V2 protein TRAPPC-Trs85 PF12739.7 KII62376.1 - 0.25 10.3 4.4 1.4 7.8 0.0 2.4 1 1 1 2 2 2 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_11 PF13414.6 KII62376.1 - 0.56 9.9 6.3 0.4 10.4 1.0 3.1 2 1 1 3 3 3 0 TPR repeat TPR_1 PF00515.28 KII62376.1 - 0.64 9.9 11.2 0.48 10.3 0.7 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat DDE_3 PF13358.6 KII62377.1 - 0.002 17.9 0.3 0.007 16.1 0.2 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_11 PF08279.12 KII62378.1 - 0.075 13.0 0.1 0.18 11.8 0.1 1.7 1 0 0 1 1 1 0 HTH domain CK2S PF15011.6 KII62380.1 - 0.037 13.9 0.0 0.047 13.6 0.0 1.1 1 0 0 1 1 1 0 Casein Kinase 2 substrate LEF-4 PF05098.12 KII62381.1 - 0.0092 14.8 0.1 0.011 14.6 0.1 1.2 1 0 0 1 1 1 1 Late expression factor 4 (LEF-4) DDE_3 PF13358.6 KII62383.1 - 4.3e-26 91.4 0.0 5.1e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII62383.1 - 0.0073 16.0 0.0 0.0089 15.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease pP_pnuc_2 PF18166.1 KII62385.1 - 0.088 12.9 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Predicted pPIWI-associating nuclease MULE PF10551.9 KII62386.1 - 0.0067 16.8 0.0 0.016 15.6 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain Homeodomain PF00046.29 KII62389.1 - 2.3e-08 33.8 1.7 2.3e-08 33.8 1.7 1.8 2 0 0 2 2 2 1 Homeodomain DUF4162 PF13732.6 KII62389.1 - 0.17 12.6 1.7 0.27 12.0 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) BNR PF02012.20 KII62391.1 - 0.00033 20.2 0.4 0.36 11.0 0.0 3.6 3 0 0 3 3 3 1 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII62391.1 - 0.029 13.2 0.2 0.11 11.3 0.2 1.8 1 1 0 1 1 1 0 Sortilin, neurotensin receptor 3, MSC PF09402.10 KII62391.1 - 0.16 11.4 0.3 0.21 11.0 0.3 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain RNA_helicase PF00910.22 KII62392.1 - 4.4e-06 27.0 0.0 9.7e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 RNA helicase SulA PF03846.14 KII62394.1 - 3.1e-52 175.4 4.1 4e-52 175.0 4.1 1.1 1 0 0 1 1 1 1 Cell division inhibitor SulA OmpA_membrane PF01389.17 KII62395.1 - 3.6e-74 248.5 2.5 4.9e-74 248.0 2.5 1.2 1 0 0 1 1 1 1 OmpA-like transmembrane domain OmpA PF00691.20 KII62395.1 - 2.7e-23 82.1 0.0 6e-23 81.0 0.0 1.6 1 1 0 1 1 1 1 OmpA family OMP_b-brl PF13505.6 KII62395.1 - 1.8e-18 67.3 13.3 2.8e-18 66.6 13.3 1.3 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain DUF2490 PF10677.9 KII62395.1 - 0.12 12.3 0.1 0.89 9.5 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2490) MatP PF06303.12 KII62396.1 - 1.1e-43 147.7 2.5 1.1e-43 147.7 2.5 1.6 2 0 0 2 2 2 1 MatP N-terminal domain MatP_C PF17414.2 KII62396.1 - 2.3e-30 104.5 1.2 4.7e-30 103.6 1.2 1.5 1 0 0 1 1 1 1 MatP C-terminal ribbon-helix-helix domain RHH_4 PF13467.6 KII62396.1 - 0.0004 20.2 0.1 0.00082 19.2 0.1 1.5 1 0 0 1 1 1 1 Ribbon-helix-helix domain TMF_TATA_bd PF12325.8 KII62396.1 - 0.021 15.0 2.7 0.79 10.0 2.7 2.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ELK PF03789.13 KII62396.1 - 0.046 13.8 0.2 0.083 13.0 0.2 1.4 1 0 0 1 1 1 0 ELK domain ABC_tran PF00005.27 KII62398.1 - 3.7e-24 85.8 0.0 3.1e-12 47.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KII62398.1 - 2.8e-09 37.2 0.1 0.00036 20.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 KII62398.1 - 2.9e-07 30.4 2.0 5.2e-07 29.6 2.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 KII62398.1 - 5.9e-05 23.4 0.0 0.0045 17.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KII62398.1 - 0.00099 19.5 0.7 0.0078 16.6 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 KII62398.1 - 0.0035 17.1 0.0 0.0059 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KII62398.1 - 0.0043 17.5 0.0 0.01 16.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KII62398.1 - 0.0044 16.1 0.0 0.0089 15.1 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 KII62398.1 - 0.0077 15.9 0.0 0.027 14.2 0.0 1.9 2 0 0 2 2 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KII62398.1 - 0.012 15.6 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase DUF3288 PF11691.8 KII62398.1 - 0.013 15.5 0.2 0.037 14.1 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3288) AAA_28 PF13521.6 KII62398.1 - 0.016 15.5 0.3 0.05 13.8 0.0 2.0 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 KII62398.1 - 0.018 15.1 0.1 0.043 13.8 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP-synt_ab PF00006.25 KII62398.1 - 0.028 14.1 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 KII62398.1 - 0.029 14.1 0.1 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain EF-hand_14 PF17959.1 KII62398.1 - 0.031 14.6 0.1 0.1 12.9 0.0 1.9 2 0 0 2 2 1 0 EF-hand domain Zeta_toxin PF06414.12 KII62398.1 - 0.032 13.5 0.0 0.75 9.0 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.6 KII62398.1 - 0.038 14.2 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KII62398.1 - 0.038 14.5 0.0 0.038 14.5 0.0 2.3 2 1 0 2 2 1 0 AAA domain AAA_14 PF13173.6 KII62398.1 - 0.043 13.8 0.0 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 KII62398.1 - 0.049 13.6 0.1 0.21 11.6 0.0 2.2 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 KII62398.1 - 0.057 13.3 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MobB PF03205.14 KII62398.1 - 0.059 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 KII62398.1 - 0.066 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 KII62398.1 - 0.069 13.5 0.0 0.19 12.1 0.0 1.7 2 0 0 2 2 1 0 RNA helicase AAA_7 PF12775.7 KII62398.1 - 0.089 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 KII62398.1 - 0.095 12.4 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.15 KII62398.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 KII62398.1 - 0.14 12.3 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 KII62398.1 - 0.16 11.4 0.0 0.37 10.2 0.0 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 KII62398.1 - 0.26 11.2 3.1 0.83 9.5 0.1 2.2 2 0 0 2 2 2 0 NTPase Methyltrans_SAM PF10672.9 KII62399.1 - 3.9e-22 78.7 0.1 4.8e-22 78.4 0.1 1.1 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 KII62399.1 - 1.7e-10 40.8 0.0 2.3e-10 40.4 0.0 1.3 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 KII62399.1 - 6.8e-05 22.7 0.0 8.5e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KII62399.1 - 9.2e-05 23.1 0.0 0.00018 22.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KII62399.1 - 0.00019 21.0 0.0 0.00024 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 KII62399.1 - 0.00028 21.5 0.0 0.00056 20.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 KII62399.1 - 0.0063 17.5 0.0 0.013 16.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 KII62399.1 - 0.011 15.4 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 KII62399.1 - 0.014 15.0 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase CDC37_N PF03234.14 KII62401.1 - 3.5e-16 60.3 9.2 4.6e-16 59.9 9.2 1.2 1 0 0 1 1 1 1 Cdc37 N terminal kinase binding DUF3450 PF11932.8 KII62401.1 - 0.049 12.9 4.5 0.069 12.5 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Seryl_tRNA_N PF02403.22 KII62401.1 - 0.09 13.0 5.7 0.14 12.4 5.7 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TssO PF17561.2 KII62401.1 - 0.19 11.8 9.6 0.07 13.2 5.9 1.8 1 1 1 2 2 2 0 Type VI secretion system, TssO KELK PF15796.5 KII62401.1 - 0.35 11.4 10.3 0.12 12.9 1.7 2.2 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF4446 PF14584.6 KII62401.1 - 0.35 10.9 4.6 0.13 12.3 1.7 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) FlaC_arch PF05377.11 KII62401.1 - 0.43 11.0 8.1 0.5 10.8 0.3 2.7 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 KII62401.1 - 1.2 9.7 7.4 2.3 8.7 7.4 1.6 1 0 0 1 1 1 0 Cell division protein ZapB SLATT_fungal PF18142.1 KII62401.1 - 1.4 8.9 5.6 6 6.9 0.3 2.2 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain bZIP_1 PF00170.21 KII62401.1 - 2.9 8.0 8.1 5.4 7.2 0.4 2.4 2 0 0 2 2 2 0 bZIP transcription factor DUF4140 PF13600.6 KII62401.1 - 7.7 7.0 6.4 1.3e+02 3.1 6.4 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) SH2 PF00017.24 KII62403.1 - 0.019 15.1 0.2 0.075 13.1 0.0 2.2 2 0 0 2 2 2 0 SH2 domain BLOC1_2 PF10046.9 KII62403.1 - 0.22 11.8 11.1 0.32 11.3 3.3 2.8 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF16 PF01519.16 KII62403.1 - 0.41 11.1 12.4 3.2 8.3 3.3 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 FlaC_arch PF05377.11 KII62403.1 - 0.5 10.8 7.0 2.6 8.5 0.3 3.3 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Exonuc_VII_L PF02601.15 KII62403.1 - 3.9 6.9 11.3 9.4 5.7 11.3 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 KII62403.1 - 4.3 6.1 8.5 5 5.9 8.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3552 PF12072.8 KII62403.1 - 10 5.5 17.5 11 5.4 7.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Macoilin PF09726.9 KII62404.1 - 9.1 4.7 14.1 11 4.4 14.1 1.1 1 0 0 1 1 1 0 Macoilin family Mce4_CUP1 PF11887.8 KII62406.1 - 0.014 14.8 0.0 0.015 14.8 0.0 1.1 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative PH_RBD PF12068.8 KII62407.1 - 0.0094 15.4 0.1 0.011 15.2 0.1 1.1 1 0 0 1 1 1 1 Rab-binding domain (RBD) Rapsyn_N PF10579.9 KII62410.1 - 0.023 14.8 0.2 0.21 11.7 0.2 2.2 2 0 0 2 2 2 0 Rapsyn N-terminal myristoylation and linker region RIH_assoc PF08454.11 KII62410.1 - 0.14 12.0 2.3 1.6 8.6 0.1 2.1 1 1 1 2 2 2 0 RyR and IP3R Homology associated mRNA_cap_enzyme PF01331.19 KII62411.1 - 0.017 14.9 0.1 0.059 13.2 0.0 1.9 3 0 0 3 3 3 0 mRNA capping enzyme, catalytic domain DUF4806 PF16064.5 KII62411.1 - 0.037 14.3 0.1 0.13 12.6 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4806) DUF4251 PF14059.6 KII62411.1 - 0.039 13.9 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4251) Snurportin1 PF11538.8 KII62411.1 - 0.34 11.2 1.8 0.59 10.4 1.8 1.4 1 0 0 1 1 1 0 Snurportin1 Sec63 PF02889.16 KII62415.1 - 0.056 12.6 0.1 0.068 12.3 0.1 1.2 1 0 0 1 1 1 0 Sec63 Brl domain Meth_synt_1 PF08267.12 KII62416.1 - 0.039 13.5 0.0 0.05 13.1 0.0 1.1 1 0 0 1 1 1 0 Cobalamin-independent synthase, N-terminal domain Ribosomal_S19e PF01090.19 KII62418.1 - 5e-43 146.1 0.0 5.6e-43 145.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HEPN_AbiV PF18728.1 KII62419.1 - 0.072 13.3 0.6 0.1 12.8 0.6 1.3 1 0 0 1 1 1 0 AbiV AAA PF00004.29 KII62420.1 - 3e-43 147.4 0.0 4.1e-43 147.0 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII62420.1 - 9.1e-08 32.7 0.1 3.9e-06 27.4 0.1 2.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KII62420.1 - 3.2e-07 30.6 0.0 6.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KII62420.1 - 4.5e-07 30.0 0.1 1.6e-06 28.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KII62420.1 - 8.4e-06 26.1 0.7 0.0015 18.8 0.7 2.2 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KII62420.1 - 2.8e-05 23.9 0.0 5.4e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KII62420.1 - 0.00013 22.2 0.0 0.00028 21.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 KII62420.1 - 0.00021 20.6 0.0 0.00028 20.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 KII62420.1 - 0.0012 18.7 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 KII62420.1 - 0.002 18.0 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KII62420.1 - 0.0034 16.9 0.1 0.085 12.3 0.0 2.4 2 1 0 2 2 2 1 PhoH-like protein AAA_18 PF13238.6 KII62420.1 - 0.0062 17.1 0.0 0.01 16.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 KII62420.1 - 0.0063 16.2 0.3 0.033 13.9 0.0 2.3 2 1 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 KII62420.1 - 0.009 15.4 0.2 0.024 14.0 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 KII62420.1 - 0.013 15.3 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KII62420.1 - 0.017 15.2 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KII62420.1 - 0.017 14.5 0.0 0.047 13.0 0.0 1.7 2 0 0 2 2 2 0 KaiC AAA_7 PF12775.7 KII62420.1 - 0.018 14.6 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 KII62420.1 - 0.019 15.2 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KII62420.1 - 0.019 14.9 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 KII62420.1 - 0.031 13.5 0.0 0.06 12.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 KII62420.1 - 0.043 13.7 0.0 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 KII62420.1 - 0.044 13.5 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 KII62420.1 - 0.047 13.8 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Torsin NB-ARC PF00931.22 KII62420.1 - 0.056 12.6 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain ResIII PF04851.15 KII62420.1 - 0.061 13.3 0.0 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_25 PF13481.6 KII62420.1 - 0.082 12.5 0.0 0.27 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KII62420.1 - 0.087 13.2 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.17 KII62420.1 - 0.097 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 KII62420.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 KII62420.1 - 0.13 11.9 0.0 0.69 9.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 KII62420.1 - 0.16 11.1 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 KII62420.1 - 0.16 12.5 0.0 0.3 11.6 0.0 1.6 1 1 0 1 1 1 0 ABC transporter UCH PF00443.29 KII62421.1 - 1.4e-13 50.9 0.6 2.1e-13 50.4 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KII62421.1 - 3.3e-05 23.6 0.5 5e-05 23.0 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KII62421.1 - 0.038 14.3 4.5 0.084 13.2 3.8 2.0 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein PEPCK_ATP PF01293.20 KII62421.1 - 0.073 11.7 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase PCI PF01399.27 KII62422.1 - 0.00012 22.6 0.5 0.00038 20.9 0.5 1.9 1 0 0 1 1 1 1 PCI domain LRR_RI_capping PF18779.1 KII62422.1 - 0.12 12.0 0.9 0.3 10.8 0.9 1.6 1 0 0 1 1 1 0 Capping Ribonuclease inhibitor Leucine Rich Repeat HEAT PF02985.22 KII62424.1 - 0.15 12.4 0.0 4.9 7.7 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat Serpin PF00079.20 KII62425.1 - 4.5e-36 125.0 5.7 4.9e-36 124.8 5.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CCB2_CCB4 PF11152.8 KII62426.1 - 0.048 13.0 0.3 4.3 6.6 0.1 2.1 1 1 1 2 2 2 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 Ribosomal_S19e PF01090.19 KII62427.1 - 3e-44 150.1 0.0 3.3e-44 149.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e E1-E2_ATPase PF00122.20 KII62428.1 - 7.5e-13 48.4 0.4 1.8e-12 47.1 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase zinc_ribbon_15 PF17032.5 KII62428.1 - 0.1 13.3 1.9 0.17 12.7 0.5 2.1 2 0 0 2 2 2 0 zinc-ribbon family Hydrolase PF00702.26 KII62429.1 - 6.4e-14 52.7 0.0 4.1e-10 40.3 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KII62429.1 - 0.00097 19.2 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KII62429.1 - 0.097 12.4 0.1 0.37 10.5 0.1 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ribosomal_L23eN PF03939.13 KII62432.1 - 5.2e-14 52.2 9.6 5.2e-14 52.2 9.6 2.7 4 1 0 4 4 4 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 KII62432.1 - 5.1e-11 42.8 2.4 5.1e-11 42.8 2.4 2.8 2 1 0 2 2 2 1 Ribosomal protein L23 Synaphin PF05835.12 KII62432.1 - 0.024 14.9 4.7 0.033 14.5 4.7 1.2 1 0 0 1 1 1 0 Synaphin protein RRM_1 PF00076.22 KII62433.1 - 1.7e-28 98.3 0.0 5.8e-14 51.7 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KII62433.1 - 2.4e-06 27.3 0.0 4.9e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KII62433.1 - 3.9e-05 23.6 0.0 0.0012 18.8 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 KII62433.1 - 0.011 15.9 0.0 0.14 12.3 0.0 2.3 2 1 0 2 2 2 0 RNA recognition motif Limkain-b1 PF11608.8 KII62433.1 - 0.011 15.8 0.0 1.3 9.2 0.0 2.9 2 1 1 3 3 3 0 Limkain b1 SET_assoc PF11767.8 KII62433.1 - 0.057 13.1 0.0 0.95 9.2 0.0 2.1 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated RRM_3 PF08777.11 KII62433.1 - 0.12 12.5 0.0 2.7 8.1 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif FLYWCH PF04500.16 KII62434.1 - 3.9e-07 30.1 1.0 6.9e-07 29.3 1.0 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII62435.1 - 0.025 15.0 0.3 0.057 13.8 0.1 1.7 2 0 0 2 2 2 0 MULE transposase domain Ras PF00071.22 KII62436.1 - 3.2e-61 205.7 0.3 3.8e-61 205.4 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII62436.1 - 3.3e-34 117.7 0.4 7.5e-34 116.5 0.2 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII62436.1 - 2.9e-12 46.4 0.2 3.8e-12 46.0 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KII62436.1 - 1.2e-06 28.6 0.1 2.1e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KII62436.1 - 0.00034 20.4 0.0 0.00056 19.7 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 KII62436.1 - 0.00077 19.1 0.3 0.0042 16.6 0.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 KII62436.1 - 0.00088 19.6 0.1 0.0079 16.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain Gtr1_RagA PF04670.12 KII62436.1 - 0.0034 16.8 0.1 0.0046 16.3 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KII62436.1 - 0.0034 17.3 0.1 0.021 14.7 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 KII62436.1 - 0.0099 15.6 0.0 0.024 14.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 KII62436.1 - 0.018 14.5 0.0 0.025 14.0 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KII62436.1 - 0.026 14.9 0.2 0.055 13.9 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 KII62436.1 - 0.028 14.7 0.1 0.56 10.4 0.1 2.2 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KII62436.1 - 0.031 14.8 0.2 0.043 14.3 0.2 1.6 1 1 0 1 1 1 0 ABC transporter CHAP PF05257.16 KII62436.1 - 0.042 14.4 0.1 0.069 13.7 0.1 1.4 1 0 0 1 1 1 0 CHAP domain KAP_NTPase PF07693.14 KII62436.1 - 0.067 12.4 0.0 0.081 12.1 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain TniB PF05621.11 KII62436.1 - 0.077 12.4 0.0 0.18 11.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA_21 PF13304.6 KII62436.1 - 0.12 12.1 0.1 0.21 11.3 0.0 1.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 KII62436.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AMP-binding PF00501.28 KII62437.1 - 3.9e-79 266.2 0.0 4.7e-79 266.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Ribosomal_S6 PF01250.17 KII62438.1 - 9.6e-09 35.4 0.0 1.2e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 Phosphodiest PF01663.22 KII62439.1 - 5.9e-56 190.6 0.3 7.4e-56 190.3 0.3 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PglZ PF08665.12 KII62439.1 - 0.00022 21.3 0.0 0.00038 20.6 0.0 1.3 1 0 0 1 1 1 1 PglZ domain DUF5122 PF17164.4 KII62439.1 - 0.0064 16.7 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5122) beta-propeller DDE_3 PF13358.6 KII62440.1 - 3.9e-10 39.6 0.2 5.9e-10 39.1 0.1 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease Init_tRNA_PT PF04179.12 KII62442.1 - 0.043 14.1 0.0 0.067 13.5 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain MAP65_ASE1 PF03999.12 KII62443.1 - 0.029 13.1 0.4 0.031 13.0 0.4 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Aldedh PF00171.22 KII62444.1 - 1.6e-82 277.5 0.0 2e-82 277.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family CxC5 PF18718.1 KII62444.1 - 0.0033 17.5 0.0 0.0073 16.4 0.0 1.5 1 0 0 1 1 1 1 CxC5 like cysteine cluster associated with KDZ transposases Lipoprotein_9 PF03180.14 KII62444.1 - 0.085 12.0 0.1 0.99 8.5 0.0 2.2 2 0 0 2 2 2 0 NLPA lipoprotein Lipid_DES PF08557.10 KII62444.1 - 0.21 11.1 0.5 0.4 10.2 0.5 1.4 1 0 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) MULE PF10551.9 KII62446.1 - 3.1e-11 43.5 0.1 1.4e-10 41.5 0.0 2.0 2 0 0 2 2 2 1 MULE transposase domain FLYWCH PF04500.16 KII62446.1 - 0.00016 21.7 0.1 0.00044 20.3 0.1 1.8 1 0 0 1 1 1 1 FLYWCH zinc finger domain ERAP1_C PF11838.8 KII62447.1 - 4.7e-38 131.5 2.1 6.1e-38 131.1 2.1 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 KII62448.1 - 4.4e-26 91.8 0.2 5.7e-26 91.4 0.2 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KII62449.1 - 7.6e-36 124.0 4.6 3.3e-35 122.0 4.6 1.9 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 KII62449.1 - 1.5e-18 67.1 0.1 3e-18 66.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain MaoC_dehydrat_N PF13452.6 KII62452.1 - 0.055 13.6 0.0 0.065 13.4 0.0 1.1 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase DDE_3 PF13358.6 KII62452.1 - 0.077 12.7 0.2 0.12 12.1 0.2 1.4 1 1 0 1 1 1 0 DDE superfamily endonuclease AIRS_C PF02769.22 KII62454.1 - 6e-24 84.9 0.0 8.3e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 KII62454.1 - 2.9e-05 24.6 1.3 5.7e-05 23.7 0.7 1.8 2 1 0 2 2 2 1 AIR synthase related protein, N-terminal domain DDE_Tnp_IS1595 PF12762.7 KII62455.1 - 2.6e-09 37.3 0.0 4.4e-09 36.5 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain Arm-DNA-bind_2 PF12167.8 KII62455.1 - 0.07 13.1 0.1 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Arm DNA-binding domain LPD18 PF18832.1 KII62455.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 18 eIF3_N PF09440.10 KII62456.1 - 3.8e-10 40.3 0.5 8.7e-10 39.2 0.5 1.6 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain IMS_C PF11799.8 KII62456.1 - 0.082 13.6 0.2 0.16 12.7 0.2 1.4 1 0 0 1 1 1 0 impB/mucB/samB family C-terminal domain LisH PF08513.11 KII62456.1 - 2.3 8.3 4.4 3.3 7.8 0.6 2.7 2 0 0 2 2 2 0 LisH MULE PF10551.9 KII62458.1 - 3.8e-14 52.9 2.9 6.3e-14 52.2 1.9 1.9 2 0 0 2 2 2 1 MULE transposase domain FLYWCH PF04500.16 KII62458.1 - 1.5e-09 37.8 3.0 4.4e-09 36.3 3.0 1.8 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII62460.1 - 2.2e-10 40.8 0.0 8.9e-10 38.9 0.0 1.8 2 0 0 2 2 2 1 MULE transposase domain UcrQ PF02939.16 KII62461.1 - 0.00023 21.1 0.1 0.00033 20.5 0.1 1.4 1 0 0 1 1 1 1 UcrQ family Serpin PF00079.20 KII62462.1 - 7.1e-39 134.2 0.0 1.4e-38 133.2 0.0 1.4 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DUF716 PF04819.12 KII62464.1 - 0.05 13.2 0.4 0.059 13.0 0.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF716) DUF5381 PF17353.2 KII62464.1 - 0.1 12.3 3.9 0.13 12.0 3.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5381) YfkB PF08756.10 KII62465.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 YfkB-like domain Peptidase_C78 PF07910.13 KII62466.1 - 1.2e-44 152.4 1.0 1.9e-44 151.7 0.5 1.6 2 0 0 2 2 2 1 Peptidase family C78 Peptidase_C54 PF03416.19 KII62466.1 - 0.0035 16.8 0.3 0.32 10.4 0.0 2.6 3 0 0 3 3 3 2 Peptidase family C54 DUF1035 PF06281.12 KII62466.1 - 0.16 12.0 0.0 0.58 10.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) Ribosomal_S5_C PF03719.15 KII62467.1 - 6.7e-24 83.1 0.0 1.3e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KII62467.1 - 2.2e-22 78.8 1.3 3.7e-22 78.1 1.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain APS_kinase PF01583.20 KII62468.1 - 4.7e-28 98.1 0.0 6.1e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 KII62468.1 - 0.00047 20.3 0.1 0.1 12.8 0.1 2.0 1 1 1 2 2 2 2 AAA domain KTI12 PF08433.10 KII62468.1 - 0.0014 18.1 0.0 0.0024 17.4 0.0 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 KII62468.1 - 0.0033 18.0 0.0 0.0037 17.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KII62468.1 - 0.1 13.1 0.0 0.15 12.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 KII62468.1 - 0.15 11.9 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ATP-sulfurylase PF01747.17 KII62469.1 - 5.4e-57 192.7 0.0 6.1e-57 192.5 0.0 1.0 1 0 0 1 1 1 1 ATP-sulfurylase DUF1279 PF06916.13 KII62470.1 - 0.00038 21.0 3.3 0.0018 18.8 2.9 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) BolA PF01722.18 KII62472.1 - 5.8e-24 84.2 0.1 7.6e-24 83.8 0.1 1.1 1 0 0 1 1 1 1 BolA-like protein zf-HIT PF04438.16 KII62474.1 - 2.7e-07 30.4 15.3 7.8e-07 28.9 15.3 1.8 1 0 0 1 1 1 1 HIT zinc finger YacG PF03884.14 KII62474.1 - 1 9.1 9.4 2.5 7.9 9.4 1.7 1 0 0 1 1 1 0 DNA gyrase inhibitor YacG zf-AN1 PF01428.16 KII62474.1 - 2 8.7 12.7 5.5 7.2 12.7 1.8 1 0 0 1 1 1 0 AN1-like Zinc finger DEAD PF00270.29 KII62476.1 - 1e-10 41.7 0.0 1.9e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII62477.1 - 2.6e-15 56.7 0.3 8.4e-15 55.1 0.1 1.8 1 1 1 2 2 2 1 Helicase conserved C-terminal domain Cys_Met_Meta_PP PF01053.20 KII62477.1 - 0.031 12.8 0.0 0.044 12.3 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme GH43_C2 PF17851.1 KII62477.1 - 0.068 12.9 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 Beta xylosidase C-terminal Concanavalin A-like domain Sortilin-Vps10 PF15902.5 KII62478.1 - 9e-07 28.0 0.1 1.1e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, DUF2326 PF10088.9 KII62478.1 - 0.038 13.7 0.0 0.078 12.7 0.0 1.5 1 1 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2326) Sortilin-Vps10 PF15902.5 KII62480.1 - 3.1e-09 36.1 0.6 3.3e-07 29.5 0.0 2.4 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII62480.1 - 0.055 13.8 0.2 0.094 13.1 0.2 1.3 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII62480.1 - 1.1 9.5 10.3 10 6.6 0.8 3.6 3 0 0 3 3 3 0 BNR/Asp-box repeat COOH-NH2_lig PF14395.6 KII62483.1 - 0.083 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Phage phiEco32-like COOH.NH2 ligase-type 2 Sortilin-Vps10 PF15902.5 KII62486.1 - 4.2e-13 48.9 2.6 3.1e-12 46.1 2.6 1.9 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII62486.1 - 7.1e-07 29.7 1.1 1.2e-06 29.0 1.1 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII62486.1 - 0.00069 19.2 6.7 0.41 10.8 0.1 3.9 3 0 0 3 3 3 2 BNR/Asp-box repeat GT-D PF08759.11 KII62488.1 - 0.035 13.8 0.0 0.038 13.6 0.0 1.0 1 0 0 1 1 1 0 Glycosyltransferase GT-D fold SNAP PF14938.6 KII62489.1 - 1.9e-35 122.7 16.7 2.2e-35 122.4 16.7 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Sel1 PF08238.12 KII62489.1 - 0.0085 16.7 4.0 0.45 11.3 0.5 3.7 3 0 0 3 3 3 1 Sel1 repeat TPR_6 PF13174.6 KII62489.1 - 0.017 15.7 4.3 7.1 7.5 0.0 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat KAsynt_C_assoc PF16197.5 KII62489.1 - 0.027 14.9 0.2 2.2 8.8 0.1 2.3 1 1 1 2 2 2 0 Ketoacyl-synthetase C-terminal extension TPR_12 PF13424.6 KII62489.1 - 0.045 14.0 7.3 6.5 7.1 0.6 4.1 2 2 2 4 4 4 0 Tetratricopeptide repeat E1_DerP2_DerF2 PF02221.15 KII62492.1 - 4e-08 33.8 0.4 4.4e-08 33.6 0.4 1.1 1 0 0 1 1 1 1 ML domain Stanniocalcin PF03298.13 KII62492.1 - 0.024 13.9 0.2 0.033 13.5 0.2 1.2 1 0 0 1 1 1 0 Stanniocalcin family RVT_1 PF00078.27 KII62494.1 - 4.4e-06 26.4 0.0 5.8e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LAP2alpha PF11560.8 KII62495.1 - 0.007 15.8 0.0 0.0086 15.5 0.0 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 2 alpha HTH_23 PF13384.6 KII62499.1 - 0.0053 16.5 0.0 0.0089 15.8 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Crp_2 PF13545.6 KII62499.1 - 0.014 15.4 0.1 0.022 14.8 0.1 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_28 PF13518.6 KII62499.1 - 0.081 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MLVIN_C PF18697.1 KII62502.1 - 0.0081 16.2 0.0 0.02 15.0 0.0 1.7 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain LLC1 PF14945.6 KII62503.1 - 0.25 11.9 3.5 0.4 11.3 2.6 1.9 1 1 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein DUF4196 PF13846.6 KII62506.1 - 0.035 14.3 2.1 0.057 13.6 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4196) CTNNBL PF08216.11 KII62506.1 - 0.038 14.2 0.6 4.2 7.6 0.1 2.4 1 1 1 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear zf-CCHC_2 PF13696.6 KII62506.1 - 0.061 13.1 2.1 0.061 13.1 2.1 1.8 2 0 0 2 2 2 0 Zinc knuckle eIF3g PF12353.8 KII62506.1 - 1 9.8 7.8 59 4.1 6.4 2.7 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G FtsL PF04999.13 KII62509.1 - 0.015 15.2 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Cell division protein FtsL ATP13 PF12921.7 KII62509.1 - 0.061 13.2 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial ATPase expression PAP_central PF04928.17 KII62509.1 - 0.13 11.2 0.1 0.18 10.7 0.1 1.2 1 0 0 1 1 1 0 Poly(A) polymerase central domain Sortilin_C PF15901.5 KII62510.1 - 1.3e-15 58.2 5.4 1.8e-15 57.7 5.4 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal MLVIN_C PF18697.1 KII62514.1 - 0.00037 20.5 0.0 0.00077 19.5 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DDE_1 PF03184.19 KII62516.1 - 3e-06 27.0 0.0 4.1e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.6 KII62517.1 - 5.3e-08 32.6 0.4 9.7e-08 31.8 0.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Peptidase_M24_C PF16188.5 KII62517.1 - 0.088 12.9 0.3 0.24 11.5 0.3 1.8 1 0 0 1 1 1 0 C-terminal region of peptidase_M24 DegS PF05384.11 KII62517.1 - 0.25 10.8 2.6 0.97 8.9 1.0 2.5 2 1 0 2 2 2 0 Sensor protein DegS SNAP PF14938.6 KII62518.1 - 1.2e-06 28.2 5.4 1.7e-06 27.7 5.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Peptidase_M24_C PF16188.5 KII62518.1 - 0.0066 16.5 2.2 0.52 10.4 0.5 2.5 1 1 1 2 2 2 2 C-terminal region of peptidase_M24 HEPN_Swt1 PF18731.1 KII62518.1 - 0.097 13.0 0.5 0.19 12.1 0.2 1.7 2 0 0 2 2 2 0 Swt1-like HEPN RhoGAP PF00620.27 KII62518.1 - 0.13 12.1 1.0 2 8.3 0.3 2.0 2 0 0 2 2 2 0 RhoGAP domain TPR_2 PF07719.17 KII62518.1 - 0.97 9.7 6.2 7.9 6.9 0.2 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII62518.1 - 5.9 7.4 8.0 40 4.8 0.2 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII62518.1 - 8.7 6.4 7.4 15 5.6 0.4 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF1730 PF08331.10 KII62519.1 - 0.04 13.8 0.2 11 6.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1730) Peptidase_M24_C PF16188.5 KII62519.1 - 0.14 12.2 0.2 0.36 10.9 0.2 1.6 1 0 0 1 1 1 0 C-terminal region of peptidase_M24 T4SS PF07996.11 KII62519.1 - 0.19 12.1 2.3 0.5 10.7 0.6 2.2 2 1 0 2 2 2 0 Type IV secretion system proteins Glycophorin_A PF01102.18 KII62520.1 - 0.00048 20.3 0.4 0.00072 19.8 0.4 1.2 1 0 0 1 1 1 1 Glycophorin A Shisa PF13908.6 KII62520.1 - 0.0019 18.5 0.8 0.0019 18.5 0.8 1.7 2 0 0 2 2 1 1 Wnt and FGF inhibitory regulator NS3_envE PF02723.14 KII62520.1 - 0.0046 17.0 6.2 0.0046 17.0 6.2 1.6 2 0 0 2 2 1 1 Non-structural protein NS3/Small envelope protein E EphA2_TM PF14575.6 KII62520.1 - 0.0056 17.5 0.7 0.01 16.7 0.7 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain MLANA PF14991.6 KII62520.1 - 0.016 15.5 0.5 0.062 13.6 1.2 1.7 2 0 0 2 2 2 0 Protein melan-A TMEM154 PF15102.6 KII62520.1 - 0.025 14.5 5.2 0.037 14.0 5.2 1.1 1 0 0 1 1 1 0 TMEM154 protein family ECSCR PF15820.5 KII62520.1 - 0.032 14.1 4.7 0.055 13.3 4.7 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator RCR PF12273.8 KII62520.1 - 0.065 13.9 2.6 0.12 13.1 2.6 1.5 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red TRP PF06011.12 KII62520.1 - 0.21 10.3 3.1 0.28 9.9 3.1 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Adeno_E3_CR2 PF02439.15 KII62520.1 - 0.22 11.3 17.8 0.46 10.3 17.8 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Collectrin PF16959.5 KII62520.1 - 0.25 11.1 3.6 0.34 10.7 3.6 1.2 1 0 0 1 1 1 0 Renal amino acid transporter Prominin PF05478.11 KII62520.1 - 0.83 7.5 8.9 1 7.2 8.9 1.1 1 0 0 1 1 1 0 Prominin Stevor PF17410.2 KII62520.1 - 1.1 8.7 4.0 1.4 8.4 4.0 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Syndecan PF01034.20 KII62520.1 - 1.1 9.2 8.3 2.1 8.4 8.3 1.4 1 0 0 1 1 1 0 Syndecan domain PRIMA1 PF16101.5 KII62520.1 - 2.1 8.4 6.2 3.5 7.7 6.2 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Orf78 PF06024.12 KII62520.1 - 2.8 8.3 4.9 4.3 7.7 4.9 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DAG1 PF05454.11 KII62520.1 - 7.9 5.8 6.5 12 5.2 6.5 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) SNAP PF14938.6 KII62521.1 - 8e-11 41.9 10.7 1.2e-10 41.3 10.7 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NSF PF02071.20 KII62521.1 - 2.3 9.3 9.4 6 8.1 0.1 4.1 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat SIT PF15330.6 KII62522.1 - 0.00024 21.5 0.0 0.00039 20.8 0.0 1.3 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT Amnionless PF14828.6 KII62522.1 - 0.0028 16.6 14.7 0.0059 15.5 12.7 1.9 1 1 1 2 2 2 1 Amnionless DUF2208 PF09973.9 KII62522.1 - 0.0059 16.3 0.0 0.0075 15.9 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2208) PspB PF06667.12 KII62522.1 - 0.021 14.8 0.0 0.1 12.6 0.0 1.9 2 0 0 2 2 2 0 Phage shock protein B Stevor PF17410.2 KII62522.1 - 0.025 14.2 0.1 0.031 13.8 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Foamy_virus_ENV PF03408.14 KII62522.1 - 0.025 12.4 0.1 0.028 12.3 0.1 1.1 1 0 0 1 1 1 0 Foamy virus envelope protein DUF1673 PF07895.11 KII62522.1 - 0.028 14.1 0.1 0.035 13.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) TMEM154 PF15102.6 KII62522.1 - 0.055 13.4 0.0 0.078 12.9 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family OSTbeta PF15048.6 KII62522.1 - 0.078 13.1 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein OAD_gamma PF04277.13 KII62522.1 - 0.1 13.2 0.1 0.14 12.8 0.1 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain EphA2_TM PF14575.6 KII62522.1 - 0.12 13.3 0.0 0.19 12.6 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 KII62522.1 - 0.13 13.2 0.0 0.19 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 KII62523.1 - 0.018 15.9 0.0 0.035 15.0 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Stevor PF17410.2 KII62523.1 - 0.02 14.4 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame ASFV_J13L PF05568.11 KII62523.1 - 0.024 14.4 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein LapA_dom PF06305.11 KII62523.1 - 0.14 12.0 0.1 0.21 11.4 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Baculo_11_kDa PF06143.11 KII62523.1 - 0.82 9.3 4.5 0.2 11.3 1.0 1.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family ECSCR PF15820.5 KII62523.1 - 4.7 7.1 6.2 2.9 7.8 2.7 2.2 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator Orf78 PF06024.12 KII62523.1 - 5 7.5 6.0 0.34 11.2 0.3 1.9 2 0 0 2 2 2 0 Orf78 (ac78) DUF3079 PF11278.8 KII62524.1 - 0.006 16.4 4.2 0.006 16.4 4.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3079) Insulin_TMD PF17870.1 KII62524.1 - 0.015 15.4 0.1 0.025 14.7 0.1 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF2985 PF11204.8 KII62524.1 - 0.071 13.3 0.1 0.11 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) DAG1 PF05454.11 KII62524.1 - 0.15 11.4 0.4 0.19 11.1 0.4 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Collectrin PF16959.5 KII62524.1 - 0.15 11.8 0.4 0.24 11.2 0.4 1.3 1 0 0 1 1 1 0 Renal amino acid transporter MMS19_C PF12460.8 KII62526.1 - 2.3e-05 23.7 0.0 0.00042 19.6 0.0 2.3 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal HEAT PF02985.22 KII62527.1 - 9.5e-12 44.1 5.2 4.4e-05 23.4 0.0 5.2 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 KII62527.1 - 3.6e-09 36.9 0.0 0.005 17.3 0.0 3.8 3 0 0 3 3 3 2 HEAT-like repeat RTP1_C1 PF10363.9 KII62527.1 - 0.001 19.2 0.1 0.12 12.6 0.1 2.9 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 KII62527.1 - 0.0011 19.4 0.0 0.048 14.0 0.0 3.4 3 1 2 5 5 5 2 HEAT repeats Cnd1 PF12717.7 KII62527.1 - 0.012 15.7 0.9 0.13 12.3 0.1 2.5 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KII62527.1 - 0.013 14.1 1.6 1.7 7.1 0.2 2.2 2 0 0 2 2 2 0 Adaptin N terminal region Arm PF00514.23 KII62527.1 - 0.032 14.3 0.1 23 5.2 0.0 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DCB PF16213.5 KII62527.1 - 0.14 11.8 0.9 0.3 10.7 0.9 1.5 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 MMS19_C PF12460.8 KII62527.1 - 0.2 10.7 1.9 8.9 5.3 0.0 2.4 2 1 0 2 2 2 0 RNAPII transcription regulator C-terminal RVT_1 PF00078.27 KII62528.1 - 2.8e-05 23.7 0.0 4.9e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_3 PF13917.6 KII62528.1 - 0.00038 20.4 12.6 0.023 14.7 2.0 2.6 1 1 1 2 2 2 2 Zinc knuckle gag-asp_proteas PF13975.6 KII62528.1 - 0.00057 20.4 0.0 0.0013 19.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Peptidase_A2E PF12382.8 KII62528.1 - 0.0082 16.2 0.3 0.015 15.3 0.3 1.4 1 0 0 1 1 1 1 Retrotransposon peptidase Retrotran_gag_2 PF14223.6 KII62528.1 - 0.018 14.7 0.1 0.12 12.0 0.1 2.1 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type Asp_protease_2 PF13650.6 KII62528.1 - 0.061 14.0 0.0 0.13 13.0 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 KII62528.1 - 0.073 13.2 13.9 1.4 9.1 5.9 2.7 2 0 0 2 2 2 0 Zinc knuckle RVP PF00077.20 KII62528.1 - 0.083 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease RVT_1 PF00078.27 KII62529.1 - 3.6e-13 49.5 0.1 4.9e-13 49.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tudor_3 PF18115.1 KII62530.1 - 0.015 15.1 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain RhoGEF67_u1 PF16615.5 KII62530.1 - 0.46 11.0 3.3 0.83 10.2 2.4 1.9 2 0 0 2 2 2 0 Unstructured region one on RhoGEF 6 and 7 DDE_3 PF13358.6 KII62531.1 - 2e-05 24.4 0.1 4.3e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease AAA_lid_5 PF17865.1 KII62533.1 - 0.086 12.9 0.5 0.12 12.5 0.5 1.2 1 0 0 1 1 1 0 Midasin AAA lid domain GNVR PF13807.6 KII62534.1 - 0.075 13.0 0.1 0.16 11.9 0.1 1.6 1 1 0 1 1 1 0 G-rich domain on putative tyrosine kinase DUF4371 PF14291.6 KII62535.1 - 0.007 16.0 0.4 0.025 14.2 0.2 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4371) Pro_isomerase PF00160.21 KII62537.1 - 5.6e-37 127.4 1.4 7e-37 127.1 1.4 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Transketolase_C PF02780.20 KII62538.1 - 7.6e-43 145.3 0.1 2e-42 144.0 0.0 1.6 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 KII62538.1 - 1.9e-14 53.7 0.0 2.9e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 KII62538.1 - 0.0059 16.9 0.0 0.024 14.9 0.0 1.9 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II DUF4371 PF14291.6 KII62539.1 - 2.7e-12 46.8 0.1 2.7e-12 46.8 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 KII62539.1 - 2.4e-06 27.2 0.1 5.8e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region PolyA_pol PF01743.20 KII62540.1 - 0.27 11.7 2.3 0.66 10.4 2.3 1.7 1 1 1 2 2 2 0 Poly A polymerase head domain MULE PF10551.9 KII62541.1 - 2e-06 28.1 0.0 4.4e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.18 KII62541.1 - 0.0062 15.4 0.3 0.0085 15.0 0.3 1.4 1 1 0 1 1 1 1 Transposase, Mutator family HydF_dimer PF18128.1 KII62544.1 - 0.14 12.2 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 Hydrogen maturase F dimerization domain DUF1929 PF09118.11 KII62545.1 - 0.053 13.8 0.0 0.085 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1929) Serpin PF00079.20 KII62546.1 - 8.5e-28 97.7 0.8 1e-27 97.4 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Xrn1_D3 PF18194.1 KII62546.1 - 0.015 15.3 0.7 0.13 12.4 0.1 2.3 2 0 0 2 2 2 0 Exoribonuclease 1 Domain-3 UPF0203 PF05254.12 KII62547.1 - 0.14 12.4 0.2 0.6 10.4 0.0 2.1 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0203) SNAP PF14938.6 KII62548.1 - 2.6e-06 27.1 0.9 3.9e-06 26.5 0.9 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Cactin_mid PF10312.9 KII62548.1 - 0.01 15.6 0.1 0.016 15.0 0.1 1.3 1 0 0 1 1 1 0 Conserved mid region of cactin SNAP PF14938.6 KII62550.1 - 6.1e-05 22.6 0.1 8e-05 22.2 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Sortilin-Vps10 PF15902.5 KII62551.1 - 0.017 13.9 0.0 0.017 13.9 0.0 1.0 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, CX9C PF16860.5 KII62552.1 - 0.12 12.3 0.2 0.25 11.4 0.2 1.5 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, S-AdoMet_synt_M PF02772.16 KII62552.1 - 0.25 11.6 1.4 0.54 10.5 0.5 1.9 1 1 1 2 2 2 0 S-adenosylmethionine synthetase, central domain rve PF00665.26 KII62553.1 - 1.2e-08 35.2 0.0 2.6e-08 34.0 0.0 1.5 1 1 1 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII62553.1 - 0.00078 19.5 3.6 0.0013 18.8 3.6 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain HTH_33 PF13592.6 KII62555.1 - 0.02 14.5 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix Peptidase_S8 PF00082.22 KII62556.1 - 2.6e-20 72.9 2.9 8.3e-20 71.2 2.9 1.8 1 1 0 1 1 1 1 Subtilase family Gly-zipper_Omp PF13488.6 KII62556.1 - 0.65 10.0 7.2 0.28 11.2 3.5 2.2 2 0 0 2 2 2 0 Glycine zipper rve PF00665.26 KII62558.1 - 7.1e-16 58.5 0.0 9.4e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII62558.1 - 7.1e-05 22.5 0.1 0.00013 21.7 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain DUF3798 PF12683.7 KII62558.1 - 0.007 15.8 0.0 0.0086 15.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3798) Poty_PP PF08440.10 KII62558.1 - 0.036 13.1 0.1 0.049 12.7 0.1 1.1 1 0 0 1 1 1 0 Potyviridae polyprotein Integrase_H2C2 PF17921.1 KII62559.1 - 9.3e-10 38.5 0.4 4e-08 33.2 0.0 2.6 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 KII62559.1 - 2.4e-08 33.9 0.0 1.5e-07 31.4 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII62560.1 - 7.1e-16 58.5 0.0 9.4e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII62560.1 - 7.1e-05 22.5 0.1 0.00013 21.7 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain DUF3798 PF12683.7 KII62560.1 - 0.007 15.8 0.0 0.0086 15.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3798) Poty_PP PF08440.10 KII62560.1 - 0.036 13.1 0.1 0.049 12.7 0.1 1.1 1 0 0 1 1 1 0 Potyviridae polyprotein Integrase_H2C2 PF17921.1 KII62561.1 - 9.2e-09 35.3 0.0 2.2e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 KII62561.1 - 9.5e-09 35.2 0.0 7.7e-08 32.3 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Arm PF00514.23 KII62563.1 - 3.7e-20 71.3 4.1 0.025 14.6 0.0 8.5 9 0 0 9 9 9 6 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KII62563.1 - 1.7e-08 33.9 1.1 4.3e-08 32.6 1.1 1.7 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 KII62563.1 - 0.00071 20.0 0.0 2.3 8.8 0.0 4.8 5 1 0 5 5 5 1 HEAT-like repeat HEAT_2 PF13646.6 KII62563.1 - 0.0017 18.7 0.0 8.9 6.8 0.0 4.2 3 2 0 3 3 3 1 HEAT repeats PPV_E2_N PF00508.17 KII62563.1 - 0.098 12.0 0.0 0.27 10.5 0.0 1.7 2 0 0 2 2 2 0 E2 (early) protein, N terminal Ldl_recept_a PF00057.18 KII62565.1 - 3.4e-05 24.0 26.1 6e-05 23.2 15.6 3.2 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A gp45-slide_C PF09116.10 KII62566.1 - 0.082 13.0 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 gp45 sliding clamp, C terminal DUF5301 PF17225.3 KII62567.1 - 0.12 12.8 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) DDE_1 PF03184.19 KII62569.1 - 1.3e-08 34.7 0.0 1.9e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.6 KII62570.1 - 8.6e-14 51.6 2.8 1.2e-13 51.2 2.8 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP OSTMP1 PF09777.9 KII62570.1 - 0.0025 17.3 3.5 0.0052 16.2 3.5 1.6 1 1 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor TPR_8 PF13181.6 KII62570.1 - 0.0026 17.8 2.6 0.024 14.8 0.4 4.5 6 0 0 6 6 6 2 Tetratricopeptide repeat DUF4709 PF15821.5 KII62570.1 - 0.0056 16.9 0.4 0.012 15.9 0.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4709) TPR_2 PF07719.17 KII62570.1 - 0.0071 16.4 11.9 0.17 12.1 0.4 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 KII62570.1 - 0.0084 16.1 6.0 0.86 9.8 0.1 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII62570.1 - 0.0099 16.2 2.3 0.38 11.1 0.1 3.4 2 2 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KII62570.1 - 0.011 15.5 0.4 0.011 15.5 0.4 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KII62570.1 - 0.015 15.8 2.2 27 5.4 0.1 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 KII62570.1 - 0.015 15.5 2.3 22 5.6 0.2 4.2 4 0 0 4 4 4 0 PPR repeat PAZ_siRNAbind PF12212.8 KII62570.1 - 0.023 14.5 3.8 0.029 14.2 1.4 2.1 1 1 0 2 2 2 0 PAZ domain DUF3986 PF13143.6 KII62570.1 - 0.024 15.6 1.9 0.07 14.1 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3986) MRP-S23 PF10484.9 KII62570.1 - 0.1 12.9 2.0 0.22 11.8 2.0 1.6 1 1 0 1 1 1 0 Mitochondrial ribosomal protein S23 DUF3136 PF11334.8 KII62570.1 - 0.11 12.3 0.3 0.34 10.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3136) TPR_14 PF13428.6 KII62570.1 - 0.13 13.2 1.1 8.8 7.4 0.0 3.6 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KII62570.1 - 0.2 12.4 1.8 35 5.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KII62570.1 - 0.62 10.8 2.2 56 4.7 0.0 3.5 4 1 0 4 4 3 0 Tetratricopeptide repeat Xylo_C PF12529.8 KII62574.1 - 0.049 13.2 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Xylosyltransferase C terminal FAD_binding_9 PF08021.11 KII62575.1 - 0.17 12.1 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Hydrolase_6 PF13344.6 KII62577.1 - 7.6e-16 58.1 0.0 1.1e-12 47.9 0.0 3.2 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KII62577.1 - 4e-15 55.6 0.0 1e-14 54.4 0.0 1.7 1 1 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KII62577.1 - 3.8e-09 37.2 0.0 6.6e-09 36.4 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KII62577.1 - 6.4e-06 26.4 0.0 2.8e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase SH2_2 PF14633.6 KII62579.1 - 7.5e-55 185.7 5.2 9.8e-55 185.3 5.2 1.1 1 0 0 1 1 1 1 SH2 domain S1 PF00575.23 KII62579.1 - 2e-06 28.0 0.1 5.3e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 S1 RNA binding domain SH2 PF00017.24 KII62579.1 - 4.3e-06 26.7 0.1 0.00078 19.5 0.0 2.6 2 0 0 2 2 2 2 SH2 domain Dimer_Tnp_hAT PF05699.14 KII62580.1 - 9.5e-08 31.7 0.1 2.4e-07 30.5 0.1 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Evf PF18270.1 KII62582.1 - 0.039 13.4 0.2 0.089 12.2 0.2 1.6 1 0 0 1 1 1 0 Virulence factor Evf Swi3 PF07962.12 KII62583.1 - 3.1e-12 46.3 0.2 4.9e-12 45.7 0.2 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 TF_AP-2 PF03299.14 KII62583.1 - 0.081 12.9 0.3 0.11 12.5 0.3 1.2 1 0 0 1 1 1 0 Transcription factor AP-2 DUF5089 PF17002.5 KII62583.1 - 0.75 9.6 8.9 0.031 14.2 2.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) Cse1 PF08506.10 KII62584.1 - 8e-48 163.1 0.1 1.6e-47 162.1 0.1 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 KII62584.1 - 7.4e-18 64.3 7.3 2e-16 59.6 4.7 2.7 3 1 0 3 3 3 2 CAS/CSE protein, C-terminus DDE_3 PF13358.6 KII62585.1 - 0.047 13.4 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease OATP PF03137.20 KII62586.1 - 3.8e-34 117.9 13.6 4.6e-34 117.6 13.6 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KII62586.1 - 6.7e-09 35.1 8.9 1.8e-08 33.7 8.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 KII62586.1 - 0.13 12.0 8.2 0.055 13.2 4.7 2.1 1 1 1 2 2 2 0 Ion channel regulatory protein UNC-93 ABC2_membrane_2 PF12679.7 KII62586.1 - 0.68 9.2 8.3 1.1 8.4 8.3 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein SPC25 PF06703.11 KII62586.1 - 8.6 6.1 7.7 1.8 8.4 2.3 2.5 1 1 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) FliG_M PF14841.6 KII62587.1 - 0.029 14.6 0.1 0.05 13.8 0.1 1.5 1 0 0 1 1 1 0 FliG middle domain DUF4040 PF13244.6 KII62588.1 - 0.052 13.7 0.3 0.099 12.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) Ribosomal_L21p PF00829.21 KII62588.1 - 0.23 11.7 1.1 0.35 11.1 1.1 1.2 1 0 0 1 1 1 0 Ribosomal prokaryotic L21 protein MULE PF10551.9 KII62592.1 - 1.3e-13 51.2 0.0 2.9e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain TetR_C_15 PF17918.1 KII62594.1 - 0.076 13.8 0.1 0.18 12.6 0.1 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Exo_endo_phos PF03372.23 KII62596.1 - 2.6e-16 59.8 0.0 3.3e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MFS_2 PF13347.6 KII62598.1 - 0.00065 18.4 7.1 0.00081 18.1 7.1 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein Wzz PF02706.15 KII62598.1 - 0.056 13.7 0.1 4.6 7.6 0.0 2.6 3 0 0 3 3 3 0 Chain length determinant protein DUF3397 PF11877.8 KII62601.1 - 0.012 15.8 0.2 0.016 15.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3397) DUF1922 PF09082.10 KII62607.1 - 0.066 13.5 1.0 0.1 12.9 0.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1922) Gal_Lectin PF02140.18 KII62609.1 - 0.077 13.4 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 Galactose binding lectin domain RT_RNaseH_2 PF17919.1 KII62610.1 - 5.2e-06 26.4 0.0 1.2e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII62610.1 - 0.00017 21.8 0.0 0.00033 20.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase STAS PF01740.21 KII62610.1 - 0.01 15.4 0.0 0.041 13.5 0.0 1.9 2 1 0 2 2 2 0 STAS domain MICSWaP PF17018.5 KII62610.1 - 0.071 12.6 0.2 0.13 11.8 0.2 1.4 1 0 0 1 1 1 0 Spore wall protein Queuosine_synth PF02547.15 KII62611.1 - 0.061 12.4 0.0 0.074 12.2 0.0 1.1 1 0 0 1 1 1 0 Queuosine biosynthesis protein DDE_3 PF13358.6 KII62612.1 - 3.1e-06 27.0 0.8 4.9e-06 26.4 0.4 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease PurA PF04845.13 KII62613.1 - 3.9e-12 46.0 0.3 1.2e-07 31.3 0.3 2.1 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein FctA PF12892.7 KII62613.1 - 0.09 13.6 0.3 2.7 8.8 0.4 2.6 2 1 0 2 2 2 0 Spy0128-like isopeptide containing domain YHS PF04945.13 KII62613.1 - 0.098 12.8 0.1 3.3 7.9 0.0 2.5 2 0 0 2 2 2 0 YHS domain PurA PF04845.13 KII62614.1 - 1.1e-10 41.3 1.8 4.5e-07 29.4 0.7 2.3 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein DUF5416 PF17437.2 KII62617.1 - 0.093 12.5 0.4 0.093 12.5 0.4 1.9 2 1 0 2 2 2 0 Family of unknown function (DUF5416) RT_RNaseH PF17917.1 KII62619.1 - 2.7e-06 27.6 0.0 9.1e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII62619.1 - 0.0016 18.4 0.0 0.0045 17.0 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII62619.1 - 0.0022 17.6 0.0 0.0055 16.2 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII62619.1 - 0.032 14.3 1.0 0.073 13.2 1.0 1.7 1 0 0 1 1 1 0 Zinc knuckle gag-asp_proteas PF13975.6 KII62619.1 - 0.11 13.1 0.0 0.43 11.2 0.0 2.0 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease DDE_Tnp_IS1595 PF12762.7 KII62620.1 - 1.6e-07 31.5 0.0 6.2e-06 26.3 0.0 2.0 1 1 1 2 2 2 2 ISXO2-like transposase domain FERM_F2 PF18377.1 KII62622.1 - 0.078 12.9 0.3 0.13 12.2 0.3 1.4 1 0 0 1 1 1 0 FERM F2 acyl-CoA binding protein-like domain SRI PF08236.11 KII62625.1 - 0.00095 19.3 0.9 0.00095 19.3 0.9 1.5 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain Glycos_transf_N PF04413.16 KII62637.1 - 0.00022 20.9 0.0 0.00029 20.5 0.0 1.1 1 0 0 1 1 1 1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Bmp PF02608.14 KII62637.1 - 0.13 11.3 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like 7tm_7 PF08395.12 KII62640.1 - 0.00074 18.8 0.5 0.0018 17.6 0.5 1.6 1 0 0 1 1 1 1 7tm Chemosensory receptor CsgA PF17334.2 KII62640.1 - 0.087 13.6 2.2 3.8 8.3 0.0 3.0 2 1 1 3 3 3 0 Minor curli fiber component A ELMO_CED12 PF04727.13 KII62640.1 - 0.73 9.9 5.2 1.8 8.6 5.1 1.8 1 1 0 1 1 1 0 ELMO/CED-12 family Bot1p PF12298.8 KII62643.1 - 0.0051 17.0 0.0 0.0071 16.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein HTH_Tnp_IS630 PF01710.16 KII62643.1 - 0.061 13.4 0.0 0.092 12.8 0.0 1.3 1 0 0 1 1 1 0 Transposase GalBD_like PF17974.1 KII62649.1 - 0.04 14.1 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 Galactose-binding domain-like zf-CCHC PF00098.23 KII62650.1 - 3.3e-07 30.1 2.1 6.5e-07 29.1 2.1 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 KII62650.1 - 0.0013 18.4 0.6 0.003 17.2 0.6 1.6 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 KII62650.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein zf-CCHC_3 PF13917.6 KII62650.1 - 0.022 14.7 0.2 0.043 13.8 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle MEIOC PF15189.6 KII62650.1 - 0.17 11.5 0.3 0.41 10.2 0.0 1.7 2 0 0 2 2 2 0 Meiosis-specific coiled-coil domain-containing protein MEIOC CBM46 PF18448.1 KII62651.1 - 0.0082 16.4 0.0 0.011 16.0 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate binding domain DUF3885 PF13021.6 KII62651.1 - 0.037 14.1 0.0 0.079 13.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) HEAT PF02985.22 KII62653.1 - 1e-09 37.8 0.0 0.00078 19.5 0.0 7.4 7 0 0 7 7 7 1 HEAT repeat Cnd1 PF12717.7 KII62653.1 - 5.4e-05 23.3 36.2 0.044 13.8 1.0 8.2 6 3 2 9 9 9 5 non-SMC mitotic condensation complex subunit 1 DUF3437 PF11919.8 KII62653.1 - 0.00058 19.7 0.1 0.0033 17.3 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) UME PF08064.13 KII62653.1 - 0.011 15.7 11.7 0.035 14.0 0.5 6.3 6 1 1 7 7 7 0 UME (NUC010) domain DDE_1 PF03184.19 KII62654.1 - 2.7e-27 95.6 0.3 6.6e-27 94.3 0.3 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII62654.1 - 6.3e-05 22.9 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CtaG_Cox11 PF04442.14 KII62655.1 - 2.4e-45 154.2 0.3 4e-45 153.5 0.1 1.4 2 0 0 2 2 2 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DDE_Tnp_IS1595 PF12762.7 KII62656.1 - 2.1e-12 47.3 0.0 7.8e-12 45.5 0.0 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain Aa_trans PF01490.18 KII62661.1 - 6.3e-51 173.4 38.2 7.3e-51 173.2 38.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EGF PF00008.27 KII62662.1 - 0.00058 20.1 3.4 0.00058 20.1 3.4 4.8 3 2 1 4 4 4 2 EGF-like domain EGF_2 PF07974.13 KII62662.1 - 0.028 14.8 5.6 0.028 14.8 5.6 4.4 4 0 0 4 4 4 0 EGF-like domain hEGF PF12661.7 KII62662.1 - 0.028 15.1 2.8 0.028 15.1 2.8 5.7 6 0 0 6 6 6 0 Human growth factor-like EGF COX15-CtaA PF02628.15 KII62663.1 - 4e-59 200.3 6.9 5.7e-59 199.8 6.9 1.2 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein ABC1 PF03109.16 KII62664.1 - 1.4e-31 109.1 0.0 5.7e-31 107.1 0.0 2.0 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 KII62664.1 - 0.021 14.7 0.0 0.42 10.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Asp_protease_2 PF13650.6 KII62664.1 - 0.07 13.8 0.0 0.17 12.6 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Helicase_C PF00271.31 KII62665.1 - 1.1e-11 45.1 0.2 7.3e-11 42.4 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KII62665.1 - 0.07 12.3 0.1 0.14 11.3 0.0 1.7 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase Peptidase_S8 PF00082.22 KII62668.1 - 1.1e-34 120.1 0.0 1.9e-34 119.3 0.0 1.4 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KII62668.1 - 7.8e-13 48.3 0.0 1.3e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8 PF00082.22 KII62670.1 - 6.3e-36 124.2 0.0 9.3e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KII62670.1 - 3.2e-11 43.1 0.0 5.6e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain ASC PF00858.24 KII62670.1 - 0.085 11.8 1.0 0.13 11.2 1.0 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Rad51 PF08423.11 KII62671.1 - 4.4e-36 124.5 0.0 5.6e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KII62671.1 - 2.5e-09 37.0 0.0 3.6e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KII62671.1 - 9.6e-08 31.7 0.2 2.5e-07 30.3 0.2 1.9 1 1 0 1 1 1 1 KaiC AAA_22 PF13401.6 KII62671.1 - 9.7e-06 25.9 0.0 1.6e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 KII62671.1 - 1.3e-05 24.8 0.1 6.3e-05 22.6 0.1 1.9 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_24 PF13479.6 KII62671.1 - 0.00019 21.2 0.0 0.00029 20.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain PAXNEB PF05625.11 KII62671.1 - 0.028 13.6 0.1 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 PAXNEB protein DnaB_C PF03796.15 KII62671.1 - 0.045 13.1 0.0 0.64 9.3 0.0 2.5 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain PduV-EutP PF10662.9 KII62671.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Bac_DnaA PF00308.18 KII62671.1 - 0.092 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_16 PF13191.6 KII62671.1 - 0.1 12.9 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Tubulin PF00091.25 KII62673.1 - 4.8e-66 222.7 0.0 6.4e-66 222.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KII62673.1 - 2.6e-47 160.1 0.0 4.8e-47 159.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain zf-FPG_IleRS PF06827.14 KII62675.1 - 0.0082 16.0 0.2 0.0082 16.0 0.2 1.8 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS ThiF PF00899.21 KII62676.1 - 0.065 12.6 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 ThiF family DUF148 PF02520.17 KII62678.1 - 0.047 13.8 0.1 0.15 12.2 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF2703 PF10865.8 KII62678.1 - 0.072 13.3 0.3 2.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) Sigma70_r4_2 PF08281.12 KII62679.1 - 0.03 14.0 0.3 0.26 11.0 0.1 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 Gal-3-0_sulfotr PF06990.11 KII62680.1 - 1.3e-38 133.0 13.2 4.1e-37 128.0 13.2 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 KII62680.1 - 3.2e-06 27.2 11.1 4.9e-06 26.6 11.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Topo_Zn_Ribbon PF08272.11 KII62680.1 - 0.12 12.0 2.0 2 8.1 0.0 3.0 3 0 0 3 3 3 0 Topoisomerase I zinc-ribbon-like Pkinase PF00069.25 KII62681.1 - 5.6e-62 209.5 0.0 6.7e-62 209.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII62681.1 - 7.1e-35 120.5 0.0 1.6e-34 119.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KII62681.1 - 2.3e-05 23.5 0.1 3.3e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KII62681.1 - 0.004 16.5 0.0 0.01 15.2 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII62681.1 - 0.053 13.4 0.0 0.083 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KII62681.1 - 0.17 11.2 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.25 KII62682.1 - 1.9e-39 135.6 0.1 2.5e-39 135.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII62682.1 - 2.6e-22 79.4 0.0 3.2e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII62682.1 - 0.0001 21.7 0.0 0.00017 21.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KII62682.1 - 0.00071 19.0 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KII62682.1 - 0.0026 17.4 0.4 0.0056 16.3 0.1 1.7 2 0 0 2 2 2 1 RIO1 family Haspin_kinase PF12330.8 KII62682.1 - 0.0032 16.5 0.0 0.0036 16.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KII62682.1 - 0.0037 16.4 0.0 0.0066 15.5 0.0 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 FTA2 PF13095.6 KII62682.1 - 0.0099 15.5 0.1 2.3 7.8 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KII62682.1 - 0.053 13.4 0.1 0.61 10.0 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4371 PF14291.6 KII62683.1 - 0.0021 17.8 0.2 0.0021 17.8 0.2 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4371) DUF3402 PF11882.8 KII62685.1 - 0.0067 15.6 0.4 0.0067 15.6 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) Gal-3-0_sulfotr PF06990.11 KII62686.1 - 3.4e-40 138.2 11.6 1.3e-38 132.9 11.6 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 KII62686.1 - 7.4e-06 26.0 8.2 7.4e-06 26.0 8.2 1.8 2 0 0 2 2 2 1 Sulfotransferase family Topo_Zn_Ribbon PF08272.11 KII62686.1 - 0.055 13.1 1.0 0.13 11.9 0.0 2.1 2 0 0 2 2 2 0 Topoisomerase I zinc-ribbon-like DUF2250 PF10007.9 KII62686.1 - 0.083 13.0 0.8 0.49 10.5 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) ELL PF10390.9 KII62687.1 - 0.13 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL DnaB PF00772.21 KII62691.1 - 0.089 12.9 0.0 0.34 11.0 0.0 1.7 2 0 0 2 2 2 0 DnaB-like helicase N terminal domain FAD_binding_1 PF00667.20 KII62692.1 - 4.4e-25 88.6 0.1 5.2e-25 88.3 0.1 1.0 1 0 0 1 1 1 1 FAD binding domain AMP-binding PF00501.28 KII62694.1 - 1.3e-75 254.6 0.0 1.7e-75 254.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Integrase_H2C2 PF17921.1 KII62695.1 - 1.5e-20 73.1 0.4 3.5e-20 71.9 0.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII62695.1 - 4.9e-18 65.4 0.0 8.3e-18 64.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII62695.1 - 1.4e-05 25.2 0.3 3.9e-05 23.8 0.3 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII62695.1 - 0.00045 20.0 0.0 0.0013 18.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain HTH_23 PF13384.6 KII62696.1 - 0.02 14.7 0.0 0.12 12.2 0.1 2.2 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 KII62697.1 - 9.8e-24 83.8 0.0 1.4e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII62697.1 - 0.0011 19.2 0.0 0.0017 18.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain HTH_Tnp_Tc3_2 PF01498.18 KII62697.1 - 0.0078 16.4 0.1 0.019 15.2 0.1 1.6 1 0 0 1 1 1 1 Transposase Tn7_Tnp_TnsA_C PF08721.11 KII62697.1 - 0.009 16.6 0.4 6.4 7.5 0.1 2.5 2 0 0 2 2 2 2 TnsA endonuclease C terminal HTH_32 PF13565.6 KII62697.1 - 0.039 14.6 0.0 0.07 13.8 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DDE_3 PF13358.6 KII62698.1 - 5.1e-11 42.5 0.0 7.3e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease SpecificRecomb PF10136.9 KII62699.1 - 0.16 10.3 0.0 0.17 10.2 0.0 1.0 1 0 0 1 1 1 0 Site-specific recombinase Glutaredoxin PF00462.24 KII62701.1 - 9.4e-17 61.0 0.1 1e-15 57.7 0.0 2.1 2 0 0 2 2 2 1 Glutaredoxin DUF1180 PF06679.12 KII62702.1 - 0.006 17.0 0.1 0.0084 16.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Glycophorin_A PF01102.18 KII62702.1 - 0.036 14.3 5.4 0.089 13.0 5.4 1.6 1 1 0 1 1 1 0 Glycophorin A Serpin PF00079.20 KII62703.1 - 4.7e-38 131.5 11.8 2.5e-37 129.1 11.8 1.8 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3215 PF11503.8 KII62703.1 - 0.048 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3215) OATP PF03137.20 KII62706.1 - 1.1e-43 149.4 10.8 1.1e-43 149.4 10.8 1.3 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Kazal_2 PF07648.15 KII62706.1 - 0.00043 20.4 6.3 0.001 19.1 6.3 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1 PF07690.16 KII62706.1 - 0.00043 19.3 9.4 0.0088 15.0 4.4 2.3 3 0 0 3 3 3 2 Major Facilitator Superfamily Kazal_1 PF00050.21 KII62706.1 - 0.054 13.5 3.5 0.15 12.1 3.5 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain IU_nuc_hydro PF01156.19 KII62708.1 - 2.5e-25 89.7 0.0 3.2e-25 89.4 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase CssAB PF16831.5 KII62708.1 - 0.066 13.6 0.0 4.1 7.8 0.0 2.4 2 1 0 2 2 2 0 CS6 fimbrial subunits A and B, Coli surface antigen 6 HTH_5 PF01022.20 KII62709.1 - 0.0016 18.2 0.0 0.0026 17.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF3022 PF11226.8 KII62709.1 - 0.032 14.7 0.0 0.036 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3022) EmrE PF13536.6 KII62710.1 - 0.0035 17.0 0.5 0.023 14.3 0.0 1.9 2 0 0 2 2 2 1 Putative multidrug resistance efflux transporter DUF3810 PF12725.7 KII62710.1 - 0.48 9.7 4.9 0.47 9.8 3.5 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) Insulin_TMD PF17870.1 KII62711.1 - 0.037 14.1 2.1 0.067 13.3 2.1 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment rve PF00665.26 KII62712.1 - 6.5e-22 78.0 0.0 9.4e-22 77.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII62712.1 - 4.6e-13 49.1 0.1 9.5e-13 48.1 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII62712.1 - 1.6e-05 24.6 0.0 2.9e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII62712.1 - 0.0039 17.4 0.0 0.0082 16.3 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RdRP_5 PF07925.11 KII62713.1 - 0.19 9.1 0.0 0.22 8.9 0.0 1.0 1 0 0 1 1 1 0 Reovirus RNA-dependent RNA polymerase lambda 3 FLYWCH PF04500.16 KII62715.1 - 3e-11 43.2 1.3 4.3e-11 42.8 1.3 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain Lin-8 PF03353.15 KII62715.1 - 0.15 11.6 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MULE PF10551.9 KII62716.1 - 6.9e-07 29.6 0.0 1.3e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain YfbU PF03887.14 KII62717.1 - 0.076 13.0 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 YfbU domain TPR_1 PF00515.28 KII62718.1 - 2.6e-54 178.9 22.3 2e-08 33.7 0.2 8.4 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.17 KII62718.1 - 7e-45 147.6 15.3 2.1e-06 27.4 0.1 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 KII62718.1 - 6.9e-29 99.3 20.0 9e-10 38.1 0.4 7.4 5 1 2 7 7 7 5 TPR repeat TPR_12 PF13424.6 KII62718.1 - 1.1e-26 93.0 6.5 5.9e-08 32.9 0.0 6.4 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 KII62718.1 - 3.7e-23 79.8 23.0 0.0015 18.6 1.3 8.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 KII62718.1 - 2.1e-19 68.6 0.2 0.012 16.4 0.1 6.9 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 KII62718.1 - 1e-17 62.7 5.2 0.00023 20.9 0.1 7.6 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 KII62718.1 - 3.9e-14 51.9 8.2 0.0055 17.0 0.7 6.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KII62718.1 - 5.1e-14 52.6 0.0 0.041 14.5 0.0 5.9 4 2 2 6 6 6 4 Tetratricopeptide repeat STI1 PF17830.1 KII62718.1 - 1.1e-12 47.6 6.8 2e-12 46.8 5.1 2.3 2 0 0 2 2 2 1 STI1 domain TPR_19 PF14559.6 KII62718.1 - 1.5e-12 47.8 2.0 0.044 14.3 0.0 5.5 3 2 1 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 KII62718.1 - 4.9e-12 45.3 9.5 0.018 14.9 0.2 7.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 KII62718.1 - 1.9e-11 43.8 9.6 0.58 10.9 0.2 7.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KII62718.1 - 3.1e-07 30.4 0.0 0.03 14.4 0.0 5.0 3 2 2 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KII62718.1 - 4.5e-05 23.6 12.3 0.0067 16.6 1.3 4.2 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 KII62718.1 - 0.00015 21.5 9.4 1.1 9.0 0.5 4.5 2 2 3 5 5 5 2 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 KII62718.1 - 0.00028 20.9 8.5 0.13 12.3 0.3 5.6 5 1 1 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 KII62718.1 - 0.0016 17.8 3.3 0.26 10.4 1.2 3.2 2 2 1 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 KII62718.1 - 0.0016 17.5 11.0 0.36 9.7 0.8 4.0 2 2 1 4 4 4 2 NMDA receptor-regulated protein 1 Sel1 PF08238.12 KII62718.1 - 0.0023 18.5 1.7 9.2 7.1 0.0 4.1 4 0 0 4 4 3 0 Sel1 repeat SHNi-TPR PF10516.9 KII62718.1 - 0.0027 17.1 0.9 18 4.9 0.0 4.7 5 0 0 5 5 5 0 SHNi-TPR BTAD PF03704.17 KII62718.1 - 0.0036 17.7 0.5 0.22 12.0 0.1 3.3 2 2 2 4 4 4 1 Bacterial transcriptional activator domain TPR_MalT PF17874.1 KII62718.1 - 0.0072 15.7 0.0 0.47 9.8 0.0 3.0 2 2 1 3 3 3 1 MalT-like TPR region TPR_20 PF14561.6 KII62718.1 - 0.016 15.5 0.1 1.2 9.5 0.0 3.3 3 1 0 3 3 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 KII62718.1 - 0.027 14.5 6.5 9.1 6.3 0.9 5.3 2 2 1 3 3 3 0 Domain of Unknown Function (DUF3856) DUF5113 PF17140.4 KII62718.1 - 0.099 12.4 3.1 5 6.9 0.5 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5113) GerD PF17898.1 KII62718.1 - 0.12 12.4 8.3 0.62 10.0 1.5 3.3 2 1 1 3 3 3 0 Spore germination GerD central core domain DUF627 PF04781.12 KII62718.1 - 0.18 11.8 1.4 4.3 7.4 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF627) EGF PF00008.27 KII62719.1 - 0.0002 21.6 3.7 0.0002 21.6 3.7 2.6 3 0 0 3 3 3 1 EGF-like domain EGF_2 PF07974.13 KII62719.1 - 0.0012 19.2 5.8 0.0012 19.2 5.8 2.2 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 KII62719.1 - 0.062 14.0 2.3 0.062 14.0 2.3 3.1 2 1 0 2 2 2 0 Human growth factor-like EGF EB PF01683.18 KII62719.1 - 2.7 8.4 9.6 11 6.4 9.6 2.2 1 1 0 1 1 1 0 EB module TcpA PF05946.12 KII62720.1 - 0.11 12.7 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Toxin-coregulated pilus subunit TcpA AMP-binding PF00501.28 KII62724.1 - 1.5e-74 251.1 0.0 2.1e-74 250.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DUF759 PF05537.11 KII62724.1 - 0.037 12.9 0.1 0.055 12.3 0.1 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF759) AMP-binding PF00501.28 KII62726.1 - 2.1e-83 280.3 0.0 3e-83 279.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DDE_3 PF13358.6 KII62727.1 - 0.026 14.3 0.0 0.047 13.5 0.0 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease MtN3_slv PF03083.16 KII62728.1 - 0.012 15.7 0.5 0.023 14.7 0.5 1.5 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange AMP-binding PF00501.28 KII62729.1 - 1.7e-34 119.1 0.1 2.3e-34 118.7 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KII62729.1 - 0.00045 21.1 0.0 0.00081 20.3 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 KII62730.1 - 3.4e-28 98.4 0.0 8.6e-27 93.8 0.0 2.0 1 1 1 2 2 2 2 AMP-binding enzyme Trm112p PF03966.16 KII62731.1 - 4.1e-10 40.1 0.0 5.2e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein MFS_1 PF07690.16 KII62732.1 - 7e-22 77.8 31.8 2.1e-17 63.1 16.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PDR_assoc PF08370.11 KII62732.1 - 1.8 8.4 6.0 32 4.4 0.0 3.8 3 0 0 3 3 3 0 Plant PDR ABC transporter associated DUF3855 PF12967.7 KII62733.1 - 0.14 12.1 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3855) RabGAP-TBC PF00566.18 KII62736.1 - 0.0001 22.1 1.9 0.00027 20.7 0.7 2.0 1 1 1 2 2 2 1 Rab-GTPase-TBC domain MCM PF00493.23 KII62739.1 - 6.1e-101 336.2 0.1 1e-100 335.5 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KII62739.1 - 9.1e-38 129.0 0.3 1.9e-37 127.9 0.3 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KII62739.1 - 5.3e-27 94.1 0.4 1.5e-26 92.6 0.4 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KII62739.1 - 4.7e-18 65.7 1.2 1.4e-17 64.2 1.2 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KII62739.1 - 1.5e-08 34.3 0.0 7.5e-07 28.7 0.0 2.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KII62739.1 - 8.9e-05 22.4 0.0 0.00072 19.4 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KII62739.1 - 0.00016 21.7 0.0 0.00042 20.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 KII62739.1 - 0.0067 16.9 0.0 0.024 15.1 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KII62739.1 - 0.0094 15.7 0.1 0.14 11.9 0.0 2.5 2 1 0 2 2 2 1 Sigma-54 interaction domain Zn-ribbon_8 PF09723.10 KII62739.1 - 0.15 12.2 1.7 0.47 10.6 1.7 1.9 1 0 0 1 1 1 0 Zinc ribbon domain IL1_propep PF02394.16 KII62739.1 - 0.64 11.0 4.1 4.8 8.2 0.0 4.0 5 0 0 5 5 5 0 Interleukin-1 propeptide Chitin_synth_1 PF01644.17 KII62740.1 - 0.055 13.4 0.1 0.074 13.0 0.1 1.2 1 0 0 1 1 1 0 Chitin synthase Ras PF00071.22 KII62741.1 - 3.8e-45 153.4 2.0 1.4e-26 93.0 0.1 2.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 KII62741.1 - 1.7e-16 60.5 0.3 6.3e-15 55.4 0.0 2.3 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KII62741.1 - 1.4e-05 24.8 0.5 0.23 11.0 0.4 3.3 1 1 2 3 3 3 2 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 KII62741.1 - 0.00053 19.9 0.2 0.19 11.5 0.0 2.1 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein Arf PF00025.21 KII62741.1 - 0.001 18.6 0.4 0.14 11.6 0.0 2.1 1 1 1 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KII62741.1 - 0.003 17.5 1.0 2 8.3 0.1 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KII62741.1 - 0.012 15.7 0.1 0.015 15.3 0.1 1.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 KII62741.1 - 0.021 14.8 0.1 0.036 14.1 0.1 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_22 PF13401.6 KII62741.1 - 0.023 14.9 0.1 0.044 14.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KII62741.1 - 0.034 13.7 0.2 0.38 10.2 0.0 2.3 2 1 0 2 2 2 0 P-loop containing dynein motor region DUF3878 PF12994.7 KII62742.1 - 0.089 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3878) YabA PF06156.13 KII62742.1 - 0.11 13.2 0.2 0.51 11.0 0.0 2.1 2 0 0 2 2 2 0 Initiation control protein YabA STPPase_N PF16891.5 KII62742.1 - 0.36 11.3 2.1 2.2 8.8 0.0 2.8 3 0 0 3 3 3 0 Serine-threonine protein phosphatase N-terminal domain Glycos_transf_4 PF00953.21 KII62743.1 - 2.8e-34 118.4 14.2 2.8e-34 118.4 14.2 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 4 zf-UBR PF02207.20 KII62744.1 - 5e-17 61.8 17.8 5e-17 61.8 17.8 4.4 5 0 0 5 5 5 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 KII62744.1 - 9.9e-11 41.3 0.0 2.7e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Vps51 PF08700.11 KII62744.1 - 0.17 11.9 1.1 0.53 10.4 1.1 1.8 1 0 0 1 1 1 0 Vps51/Vps67 POPLD PF08170.12 KII62748.1 - 1.9e-08 34.6 0.0 3.2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.11 KII62748.1 - 0.001 18.9 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain POP1 PF06978.11 KII62749.1 - 5.7e-19 68.9 13.0 2.8e-12 47.1 1.8 2.0 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 DUF3843 PF12954.7 KII62749.1 - 0.0013 17.8 0.2 0.0018 17.3 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3843) IFR3_antag PF14754.6 KII62752.1 - 0.13 11.4 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 Papain-like auto-proteinase PhoQ_Sensor PF08918.10 KII62753.1 - 0.056 13.3 0.0 0.09 12.6 0.0 1.3 1 0 0 1 1 1 0 PhoQ Sensor Ldl_recept_a PF00057.18 KII62754.1 - 1e-28 99.2 80.8 1.9e-07 31.2 9.2 5.4 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A WD40 PF00400.32 KII62755.1 - 2.4e-12 47.2 0.8 0.00066 20.4 0.0 5.7 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII62755.1 - 0.0028 17.9 0.0 6.3 7.2 0.0 3.4 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain AA_permease_2 PF13520.6 KII62756.1 - 5.2e-19 68.4 26.2 5.7e-19 68.2 26.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII62756.1 - 1.1e-09 37.4 23.7 1.2e-09 37.3 23.7 1.0 1 0 0 1 1 1 1 Amino acid permease Proton_antipo_N PF00662.20 KII62756.1 - 0.0095 16.0 0.6 0.0095 16.0 0.6 2.2 2 1 0 2 2 2 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus CAF1 PF04857.20 KII62757.1 - 1.7e-22 80.0 5.4 1.5e-12 47.4 0.4 2.3 1 1 1 2 2 2 2 CAF1 family ribonuclease Runt PF00853.19 KII62757.1 - 0.12 11.9 0.2 0.24 10.9 0.2 1.4 1 0 0 1 1 1 0 Runt domain RmlD_sub_bind PF04321.17 KII62759.1 - 0.0048 16.0 0.0 0.0072 15.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain DNA_pol_A_exo1 PF01612.20 KII62761.1 - 3.4e-41 140.9 0.1 5.8e-41 140.1 0.1 1.4 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 KII62761.1 - 2.3e-05 24.3 1.0 6.7e-05 22.8 0.0 2.3 3 0 0 3 3 3 1 HRDC domain PBD PF00786.28 KII62761.1 - 0.047 14.0 0.6 0.13 12.6 0.6 1.9 1 0 0 1 1 1 0 P21-Rho-binding domain HNH_2 PF13391.6 KII62761.1 - 0.049 13.8 0.3 0.16 12.1 0.3 1.8 1 0 0 1 1 1 0 HNH endonuclease Pet100 PF09803.9 KII62762.1 - 0.15 12.6 0.4 0.6 10.7 0.4 2.0 1 0 0 1 1 1 0 Pet100 Serpin PF00079.20 KII62765.1 - 7e-20 71.7 0.2 5.4e-10 39.1 0.0 2.0 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) Cbl_N2 PF02761.14 KII62765.1 - 1.7 9.4 5.6 1.3 9.8 0.4 3.0 2 2 2 4 4 4 0 CBL proto-oncogene N-terminus, EF hand-like domain MPTase-PolyVal PF18818.1 KII62766.1 - 0.13 12.3 0.6 4.1 7.5 0.1 2.2 2 0 0 2 2 2 0 Metallopeptidase superfamily domain DAD PF02109.16 KII62767.1 - 3.6e-36 123.8 2.5 4.4e-36 123.5 2.5 1.1 1 0 0 1 1 1 1 DAD family CPP1-like PF11833.8 KII62767.1 - 0.032 13.9 0.1 0.078 12.6 0.1 1.5 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF3361 PF11841.8 KII62768.1 - 9.1e-06 25.7 2.8 1.2e-05 25.3 0.4 2.4 2 1 1 3 3 3 1 Domain of unknown function (DUF3361) Flavi_NS1 PF00948.21 KII62769.1 - 0.047 12.6 0.0 0.057 12.3 0.0 1.1 1 0 0 1 1 1 0 Flavivirus non-structural Protein NS1 PDZ PF00595.24 KII62771.1 - 6.8e-09 36.0 0.5 2.4e-08 34.2 0.1 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KII62771.1 - 6.7e-05 22.7 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII62771.1 - 0.054 13.8 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Pkinase_Tyr PF07714.17 KII62772.1 - 1.4e-20 73.7 0.4 3e-19 69.3 0.4 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KII62772.1 - 8.2e-15 54.9 1.0 1.3e-14 54.2 1.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 KII62772.1 - 7.1e-14 52.2 0.0 4.2e-13 49.7 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII62772.1 - 2.5e-10 40.7 0.1 6.8e-05 23.3 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII62772.1 - 6e-09 35.4 0.2 0.13 12.9 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KII62772.1 - 1.5e-08 34.8 0.3 0.0043 17.3 0.0 4.1 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 KII62772.1 - 2.9e-08 33.8 0.1 0.0031 17.9 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Coq4 PF05019.13 KII62774.1 - 8.8e-26 90.6 0.0 9.8e-26 90.4 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 PDZ PF00595.24 KII62775.1 - 3.5e-10 40.1 0.2 4.1e-10 39.9 0.2 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII62775.1 - 2.1e-08 33.9 0.0 3.1e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Rtf2 PF04641.12 KII62777.1 - 4.6e-70 236.0 9.4 5.6e-70 235.7 9.4 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger CO_dh PF02552.16 KII62777.1 - 0.021 14.6 1.2 0.026 14.3 0.1 1.7 2 0 0 2 2 2 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Prok-RING_4 PF14447.6 KII62777.1 - 0.11 12.4 0.7 0.34 10.8 0.8 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 TonB_N PF16031.5 KII62777.1 - 2.3 8.8 11.4 0.048 14.2 4.3 1.7 2 0 0 2 2 2 0 TonB polyproline region RHH_7 PF16777.5 KII62778.1 - 0.15 12.5 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator, RHH-like, CopG DUF3172 PF11371.8 KII62779.1 - 0.083 12.6 0.1 0.15 11.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3172) DDE_3 PF13358.6 KII62780.1 - 4.2e-10 39.6 0.0 6e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Cullin PF00888.22 KII62782.1 - 5.4e-17 61.6 12.7 7e-17 61.3 12.7 1.1 1 0 0 1 1 1 1 Cullin family Pox_G7 PF05503.12 KII62782.1 - 0.00035 19.6 0.5 0.00063 18.8 0.5 1.4 1 0 0 1 1 1 1 Poxvirus G7-like Glyco_H_20C_C PF18088.1 KII62782.1 - 0.0021 18.0 0.1 0.004 17.0 0.1 1.5 1 0 0 1 1 1 1 Glycoside Hydrolase 20C C-terminal domain DUF4413 PF14372.6 KII62782.1 - 0.0065 16.8 7.5 0.47 10.9 1.6 3.4 1 1 1 3 3 3 2 Domain of unknown function (DUF4413) CDP-OH_P_transf PF01066.21 KII62783.1 - 4.7e-15 56.1 0.3 4.7e-15 56.1 0.3 1.7 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Herpes_pp38 PF04846.13 KII62783.1 - 0.098 12.6 0.2 0.17 11.8 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein TFIIA_gamma_N PF02268.16 KII62784.1 - 1.4e-13 50.6 0.1 2.2e-13 50.0 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 KII62784.1 - 7.2e-08 32.5 0.3 1.2e-07 31.8 0.3 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit KH_1 PF00013.29 KII62785.1 - 2.8e-24 84.7 21.4 1.9e-06 27.6 0.0 10.7 11 0 0 11 11 11 8 KH domain Pribosyltran_N PF13793.6 KII62785.1 - 0.021 14.8 0.2 0.064 13.2 0.2 1.8 1 0 0 1 1 1 0 N-terminal domain of ribose phosphate pyrophosphokinase Baculo_p24 PF05073.12 KII62785.1 - 0.077 12.8 3.3 1.2 8.9 0.2 3.1 1 1 1 2 2 2 0 Baculovirus P24 capsid protein DUF2067 PF09840.9 KII62785.1 - 0.25 10.9 9.5 0.16 11.5 1.8 3.8 4 1 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2067) eIF-5_eIF-2B PF01873.17 KII62786.1 - 2.4e-37 127.4 0.5 3.2e-36 123.8 0.1 2.3 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.18 KII62786.1 - 1.5e-17 63.5 0.6 4.5e-17 62.0 0.6 1.8 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon MRP-S28 PF10213.9 KII62787.1 - 1.5e-10 41.6 0.1 3e-10 40.6 0.1 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal subunit protein RF-1 PF00472.20 KII62787.1 - 0.00032 20.6 0.1 0.00051 20.0 0.1 1.3 1 0 0 1 1 1 1 RF-1 domain P5CR_dimer PF14748.6 KII62788.1 - 3.3e-31 107.6 0.0 5e-31 107.0 0.0 1.3 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 KII62788.1 - 3.9e-13 49.8 0.5 7.3e-13 48.9 0.1 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 KII62788.1 - 0.014 15.4 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Semialdhyde_dh PF01118.24 KII62788.1 - 0.14 12.6 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain PAP2_C PF14360.6 KII62789.1 - 8.9e-21 74.2 15.2 8.9e-21 74.2 15.2 3.4 4 0 0 4 4 4 1 PAP2 superfamily C-terminal PAP2 PF01569.21 KII62789.1 - 4.5e-05 23.2 12.0 4.5e-05 23.2 12.0 2.0 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KII62789.1 - 7.5 6.2 24.4 0.44 10.2 18.2 2.1 2 1 0 2 2 2 0 PAP2 superfamily CSD2 PF17876.1 KII62790.1 - 0.012 15.8 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 0 Cold shock domain DUF5641 PF18701.1 KII62790.1 - 0.014 15.5 0.4 0.032 14.4 0.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5641) HSP70 PF00012.20 KII62791.1 - 5.7e-51 173.4 16.7 5.7e-51 173.4 16.7 3.1 1 1 2 3 3 3 1 Hsp70 protein TPP1 PF10341.9 KII62791.1 - 0.18 11.8 5.2 0.6 10.1 0.2 3.4 3 0 0 3 3 3 0 Shelterin complex subunit, TPP1/ACD PAPS_reduct PF01507.19 KII62791.1 - 8.4 6.4 7.2 2.1 8.4 0.4 2.4 1 1 1 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Ank_2 PF12796.7 KII62792.1 - 3.2e-16 59.7 0.0 2.5e-08 34.4 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KII62792.1 - 8.5e-15 53.4 0.0 1.1e-06 28.4 0.0 3.9 4 1 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KII62792.1 - 3.2e-10 40.3 0.0 1.1e-07 32.2 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KII62792.1 - 8.3e-07 29.2 0.0 0.0048 17.3 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 KII62792.1 - 2.4e-06 27.7 0.0 1.7e-05 25.0 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) HSP70 PF00012.20 KII62793.1 - 1.8e-228 759.6 7.2 2.1e-228 759.4 7.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KII62793.1 - 1.2e-11 44.1 0.1 6.6e-10 38.3 0.0 3.0 2 1 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 KII62793.1 - 0.0013 19.1 1.1 3.1 8.3 0.1 3.5 3 1 0 3 3 3 2 Cell division protein FtsA DUF3584 PF12128.8 KII62793.1 - 0.036 11.6 9.8 0.16 9.4 2.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Adipogenin PF15202.6 KII62794.1 - 0.0097 15.9 0.4 0.019 15.0 0.4 1.4 1 0 0 1 1 1 1 Adipogenin ATP-synt_8 PF00895.20 KII62794.1 - 0.095 13.2 3.2 0.19 12.2 3.2 1.6 1 0 0 1 1 1 0 ATP synthase protein 8 DotU PF09850.9 KII62794.1 - 0.25 11.0 0.0 0.33 10.6 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system protein DotU zf-C2H2 PF00096.26 KII62796.1 - 1.6e-15 56.6 27.8 0.0001 22.6 5.9 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII62796.1 - 4.5e-13 48.8 26.1 0.0034 18.1 4.3 5.1 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KII62796.1 - 1.5e-07 31.6 13.9 1.6e-06 28.3 1.5 5.8 5 2 0 5 5 5 2 Zinc-finger double domain zf-LYAR PF08790.11 KII62796.1 - 0.014 15.3 1.4 0.014 15.3 1.4 3.7 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-met PF12874.7 KII62796.1 - 0.039 14.3 1.0 0.039 14.3 1.0 4.9 5 0 0 5 5 4 0 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 KII62796.1 - 0.043 14.5 0.6 0.043 14.5 0.6 3.5 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 KII62796.1 - 0.053 13.8 0.6 0.053 13.8 0.6 5.2 5 1 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KII62796.1 - 0.12 12.0 0.1 0.12 12.0 0.1 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KII62796.1 - 0.63 10.2 0.1 0.63 10.2 0.1 4.6 4 1 1 5 5 3 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 KII62796.1 - 1 10.2 15.7 0.9 10.3 3.2 3.2 2 1 1 3 3 3 0 zinc-ribbon family zf-C2HE PF16278.5 KII62796.1 - 1.3 9.5 25.2 1.5 9.3 5.0 4.2 1 1 3 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-MYST PF17772.1 KII62796.1 - 5.6 6.6 14.1 3.4 7.3 0.0 4.2 4 1 1 5 5 5 0 MYST family zinc finger domain LIM PF00412.22 KII62796.1 - 6.3 7.1 21.0 1.5 9.1 6.0 3.9 3 1 1 4 4 4 0 LIM domain UbiA PF01040.18 KII62798.1 - 1e-18 67.6 0.3 1.1e-18 67.5 0.3 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family Sterol-sensing PF12349.8 KII62798.1 - 0.056 13.3 0.2 0.086 12.7 0.2 1.2 1 0 0 1 1 1 0 Sterol-sensing domain of SREBP cleavage-activation JmjC PF02373.22 KII62799.1 - 0.018 15.4 0.3 0.037 14.5 0.3 1.7 1 1 0 1 1 1 0 JmjC domain, hydroxylase DDE_3 PF13358.6 KII62800.1 - 2e-15 56.8 0.1 2.4e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII62802.1 - 4e-07 29.6 0.0 9.1e-07 28.5 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 KII62802.1 - 1e-06 28.7 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 KII62802.1 - 2.8e-06 27.3 0.0 5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 KII62802.1 - 3e-06 26.9 0.0 0.0002 21.1 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII62802.1 - 0.00099 19.0 0.1 0.0012 18.8 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_11 PF08279.12 KII62802.1 - 0.0097 15.8 0.2 0.018 15.0 0.2 1.4 1 0 0 1 1 1 1 HTH domain HTH_Tnp_IS630 PF01710.16 KII62802.1 - 0.01 15.8 0.2 0.012 15.7 0.2 1.2 1 0 0 1 1 1 0 Transposase HTH_Crp_2 PF13545.6 KII62802.1 - 0.013 15.4 0.1 0.03 14.3 0.0 1.6 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain HTH_32 PF13565.6 KII62802.1 - 0.013 16.0 0.0 0.055 14.1 0.0 1.8 1 1 1 2 2 2 0 Homeodomain-like domain HTH_7 PF02796.15 KII62802.1 - 0.017 15.1 1.3 0.075 13.1 0.1 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase Sigma70_r4 PF04545.16 KII62802.1 - 0.05 13.1 0.0 0.35 10.4 0.0 2.2 3 0 0 3 3 3 0 Sigma-70, region 4 TrmB PF01978.19 KII62802.1 - 0.053 13.4 0.1 0.09 12.7 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 KII62802.1 - 0.12 12.3 0.1 0.53 10.3 0.1 2.0 1 1 0 1 1 1 0 MarR family Helicase_RecD PF05127.14 KII62802.1 - 0.12 12.2 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Helicase Sigma70_r4_2 PF08281.12 KII62802.1 - 0.15 11.7 0.1 0.6 9.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 rve PF00665.26 KII62806.1 - 1.9e-23 82.9 0.0 2.5e-23 82.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII62806.1 - 6.8e-05 22.6 0.0 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII62806.1 - 0.0093 16.1 2.5 0.0093 16.1 2.5 3.3 3 1 1 4 4 4 1 Integrase zinc binding domain LupA PF18242.1 KII62806.1 - 0.015 15.0 0.1 0.015 14.9 0.1 1.1 1 0 0 1 1 1 0 Legionella ubiquitin-specific protease A domain Agenet PF05641.12 KII62807.1 - 0.055 13.9 0.1 0.37 11.3 0.0 2.2 2 0 0 2 2 2 0 Agenet domain Myosin_N PF02736.19 KII62807.1 - 0.088 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain OrfA PF17495.2 KII62808.1 - 0.16 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 Vpr-like OrfA HTH_Tnp_IS630 PF01710.16 KII62809.1 - 0.00058 19.9 0.1 0.00074 19.6 0.1 1.1 1 0 0 1 1 1 1 Transposase DUF4293 PF14126.6 KII62811.1 - 0.13 12.5 0.7 1.3 9.3 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) Vasohibin PF14822.6 KII62812.1 - 0.031 13.5 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 Vasohibin MLVIN_C PF18697.1 KII62813.1 - 0.0023 18.0 0.0 0.0048 17.0 0.0 1.6 1 1 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_2 PF13333.6 KII62816.1 - 0.28 11.4 3.6 3.8 7.8 1.0 3.1 2 1 0 2 2 2 0 Integrase core domain Apis_Csd PF11671.8 KII62818.1 - 0.023 14.7 0.6 0.049 13.6 0.4 1.7 1 1 0 1 1 1 0 Complementary sex determiner protein EGF PF00008.27 KII62818.1 - 2.8 8.3 13.7 0.095 13.0 5.6 2.6 2 1 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 KII62818.1 - 7.2 7.1 17.2 0.067 13.6 8.7 2.0 2 0 0 2 2 2 0 EGF-like domain RT_RNaseH_2 PF17919.1 KII62819.1 - 1.8e-30 104.9 0.0 2.4e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII62819.1 - 1.9e-23 82.8 0.0 2.9e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase GTP_cyclohydro2 PF00925.20 KII62819.1 - 0.065 12.8 0.0 0.089 12.4 0.0 1.1 1 0 0 1 1 1 0 GTP cyclohydrolase II Peptidase_A17 PF05380.13 KII62819.1 - 0.068 13.2 0.0 0.15 12.1 0.0 1.6 1 1 1 2 2 2 0 Pao retrotransposon peptidase ORC6 PF05460.13 KII62822.1 - 0.23 10.7 0.5 0.34 10.1 0.5 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DBINO PF13892.6 KII62824.1 - 0.012 16.0 7.1 0.013 15.9 7.1 1.2 1 0 0 1 1 1 0 DNA-binding domain FancD2 PF14631.6 KII62824.1 - 0.1 10.0 0.0 0.12 9.8 0.0 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Ferlin_C PF16165.5 KII62824.1 - 3.3 7.6 4.8 4.3 7.3 4.8 1.2 1 0 0 1 1 1 0 Ferlin C-terminus POPLD PF08170.12 KII62827.1 - 0.31 11.4 4.4 0.47 10.8 4.4 1.3 1 0 0 1 1 1 0 POPLD (NUC188) domain DUF2828 PF11443.8 KII62827.1 - 0.47 8.5 3.3 0.53 8.3 3.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) ERK-JNK_inhib PF15002.6 KII62827.1 - 5.8 6.6 12.2 1.4e+02 2.0 12.2 2.0 1 1 0 1 1 1 0 ERK and JNK pathways, inhibitor rve PF00665.26 KII62828.1 - 2.1e-08 34.4 0.2 4.2e-08 33.4 0.2 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII62828.1 - 1e-05 25.2 0.0 2.8e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Slx4 PF09494.10 KII62828.1 - 0.076 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Slx4 endonuclease DDE_3 PF13358.6 KII62830.1 - 5.1e-27 94.4 0.0 6e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII62830.1 - 0.05 13.3 0.0 0.06 13.0 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF2250 PF10007.9 KII62831.1 - 0.1 12.7 0.0 0.25 11.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) PCI PF01399.27 KII62832.1 - 1.5e-09 38.3 0.2 4.4e-09 36.8 0.1 1.9 2 0 0 2 2 2 1 PCI domain DUF2164 PF09932.9 KII62832.1 - 0.0037 17.3 1.0 0.014 15.5 0.2 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2164) zf-RanBP PF00641.18 KII62833.1 - 4.4e-07 29.1 12.0 9.8e-05 21.6 2.4 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DZR PF12773.7 KII62833.1 - 3.5 7.7 7.3 8.7 6.5 5.3 2.4 1 1 1 2 2 2 0 Double zinc ribbon eIF-3c_N PF05470.12 KII62834.1 - 1.8e-114 383.2 23.9 2.8e-114 382.6 23.9 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 KII62834.1 - 0.033 14.7 4.0 0.17 12.4 0.0 3.8 3 2 0 3 3 3 0 PCI domain TPR_1 PF00515.28 KII62834.1 - 0.19 11.6 0.6 0.58 10.1 0.3 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat Ldl_recept_a PF00057.18 KII62835.1 - 0.00057 20.0 37.2 0.017 15.4 15.1 4.1 3 1 0 3 3 3 2 Low-density lipoprotein receptor domain class A TMEM154 PF15102.6 KII62835.1 - 0.022 14.7 0.3 0.043 13.7 0.3 1.4 1 0 0 1 1 1 0 TMEM154 protein family PRIMA1 PF16101.5 KII62835.1 - 0.032 14.2 1.5 0.032 14.2 1.5 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF5305 PF17231.2 KII62835.1 - 0.081 12.3 0.2 0.13 11.6 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Cortexin PF11057.8 KII62835.1 - 0.17 11.7 2.2 0.3 11.0 2.2 1.3 1 0 0 1 1 1 0 Cortexin of kidney ODV-E18 PF10717.9 KII62835.1 - 0.19 11.6 2.1 0.31 10.9 2.1 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 EphA2_TM PF14575.6 KII62835.1 - 3.2 8.7 5.9 0.64 10.9 1.4 2.1 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ldl_recept_a PF00057.18 KII62836.1 - 1.7e-38 130.5 81.8 1.3e-10 41.3 15.0 4.9 4 1 1 5 5 5 4 Low-density lipoprotein receptor domain class A DUF5018 PF16410.5 KII62838.1 - 0.0082 14.9 0.1 0.0096 14.7 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5018) TRM PF02005.16 KII62839.1 - 0.046 12.9 0.1 0.06 12.5 0.1 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase TAFH PF07531.14 KII62840.1 - 0.013 15.5 0.0 0.018 15.1 0.0 1.2 1 0 0 1 1 1 0 NHR1 homology to TAF Ins134_P3_kin_N PF17927.1 KII62841.1 - 0.11 12.9 0.0 0.15 12.5 0.0 1.1 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain ox_reductase_C PF08635.10 KII62843.1 - 0.021 14.5 0.2 5 6.8 0.0 2.1 2 0 0 2 2 2 0 Putative oxidoreductase C terminal domain Ribosomal_L4 PF00573.22 KII62845.1 - 2.7e-27 95.7 0.0 3.9e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family tRNA-synt_1b PF00579.25 KII62846.1 - 1.1e-22 80.7 0.0 1.6e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DDE_Tnp_IS1595 PF12762.7 KII62847.1 - 0.0081 16.2 0.0 0.13 12.3 0.0 2.0 2 0 0 2 2 2 1 ISXO2-like transposase domain RRM_1 PF00076.22 KII62849.1 - 1.7e-78 258.4 4.5 2.3e-20 72.2 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KII62849.1 - 1.5e-08 34.6 6.6 0.036 14.1 2.2 4.4 3 1 1 4 4 4 3 RNA binding motif RRM_7 PF16367.5 KII62849.1 - 8.7e-07 29.0 0.1 0.75 9.9 0.0 4.7 4 0 0 4 4 4 1 RNA recognition motif RRM_5 PF13893.6 KII62849.1 - 0.00028 20.5 0.1 0.039 13.6 0.0 3.5 2 1 2 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KII62849.1 - 0.0003 20.9 0.0 0.24 11.6 0.0 3.3 3 0 0 3 3 3 1 RRM-like domain Nup35_RRM_2 PF14605.6 KII62849.1 - 0.00068 19.6 0.8 0.77 9.8 0.0 3.9 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KII62849.1 - 0.0011 18.8 0.0 2.1 8.2 0.0 3.4 3 0 0 3 3 3 1 Occluded RNA-recognition motif RNA_bind PF08675.11 KII62849.1 - 0.0096 15.9 0.2 0.36 10.9 0.0 3.3 3 0 0 3 3 3 1 RNA binding domain RRM_2 PF04059.12 KII62849.1 - 0.073 13.3 0.7 2.8 8.2 0.1 3.0 4 0 0 4 4 4 0 RNA recognition motif 2 Extensin-like_C PF06904.12 KII62849.1 - 0.086 12.9 0.2 1.5 8.8 0.1 2.4 2 0 0 2 2 2 0 Extensin-like protein C-terminus PHM7_cyt PF14703.6 KII62849.1 - 7.1 6.8 10.3 5.7 7.1 0.1 4.2 3 1 2 5 5 5 0 Cytosolic domain of 10TM putative phosphate transporter TRIQK PF15168.6 KII62853.1 - 0.019 14.8 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family Chordopox_A13L PF05961.11 KII62853.1 - 0.054 13.7 1.0 0.24 11.7 0.9 1.9 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Synaptobrevin PF00957.21 KII62853.1 - 7.6 6.4 7.2 10 6.0 6.5 1.6 1 1 0 1 1 1 0 Synaptobrevin Phage_holin_5_2 PF16079.5 KII62854.1 - 0.033 14.5 0.3 0.085 13.2 0.3 1.6 1 0 0 1 1 1 0 Phage holin family Hol44, in holin superfamily V Synaptobrevin PF00957.21 KII62854.1 - 0.11 12.2 1.1 0.22 11.3 1.1 1.6 1 0 0 1 1 1 0 Synaptobrevin Chordopox_A13L PF05961.11 KII62854.1 - 0.18 12.0 2.4 0.33 11.2 1.1 2.1 2 0 0 2 2 2 0 Chordopoxvirus A13L protein DUF3139 PF11337.8 KII62854.1 - 0.35 11.6 6.0 0.4 11.4 2.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) RVP PF00077.20 KII62855.1 - 0.011 16.0 0.0 0.031 14.6 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII62855.1 - 0.012 16.1 0.0 0.086 13.4 0.0 2.4 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease FKBP_C PF00254.28 KII62856.1 - 1.6e-12 47.6 0.0 2.4e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 KII62857.1 - 9.3e-08 31.6 2.3 0.12 12.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII62857.1 - 1.3e-06 28.1 3.1 0.17 12.0 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KII62857.1 - 0.00018 21.7 5.0 0.00078 19.6 0.2 3.2 1 1 2 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KII62857.1 - 0.00054 20.4 0.1 0.014 15.9 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII62857.1 - 0.00072 19.8 0.0 0.17 12.2 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KII62857.1 - 0.0027 17.8 0.3 0.029 14.4 0.0 2.8 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 KII62857.1 - 0.0038 17.3 5.1 0.26 11.6 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat Hexokinase_2 PF03727.16 KII62862.1 - 8.4e-67 225.1 0.0 1.1e-66 224.7 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII62862.1 - 3.7e-54 183.7 0.0 5.2e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF2464 PF10240.9 KII62863.1 - 7.8e-05 22.4 0.1 8.1e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 Multivesicular body subunit 12 Erv26 PF04148.13 KII62864.1 - 1.4e-08 34.9 11.5 7.6e-08 32.4 11.5 1.8 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 DUF2207 PF09972.9 KII62864.1 - 0.47 9.1 2.4 0.56 8.9 2.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DS PF01916.17 KII62865.1 - 9.1e-121 402.5 0.0 1e-120 402.4 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Glyco_transf_7C PF02709.14 KII62866.1 - 6.9e-08 32.1 0.4 1.3e-07 31.1 0.2 1.6 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Miga PF10265.9 KII62868.1 - 2.5e-41 142.3 7.6 3.7e-41 141.7 7.6 1.2 1 0 0 1 1 1 1 Mitoguardin K-box PF01486.17 KII62868.1 - 0.0034 17.5 1.4 0.0084 16.3 1.4 1.6 1 0 0 1 1 1 1 K-box region Pkinase PF00069.25 KII62869.1 - 3.1e-30 105.4 0.3 4e-30 105.1 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII62869.1 - 5.7e-18 65.1 0.0 7.4e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KII62869.1 - 1.2e-07 30.9 0.3 1.6e-07 30.4 0.3 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KII62869.1 - 0.00028 20.9 0.0 0.00045 20.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KII62869.1 - 0.026 13.8 0.4 0.11 11.8 0.0 2.1 3 0 0 3 3 3 0 Kinase-like EMC3_TMCO1 PF01956.16 KII62870.1 - 8.6e-23 80.9 1.8 9.7e-23 80.8 1.8 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Na_K-ATPase PF00287.18 KII62871.1 - 0.0098 15.1 0.0 0.5 9.5 0.0 2.0 1 1 1 2 2 2 2 Sodium / potassium ATPase beta chain GAF PF01590.26 KII62872.1 - 5.4e-14 53.0 0.0 1.1e-11 45.5 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 KII62872.1 - 0.014 15.7 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 GAF domain GAF_3 PF13492.6 KII62872.1 - 0.11 12.8 0.0 11 6.4 0.0 2.7 2 1 0 2 2 2 0 GAF domain DUF3795 PF12675.7 KII62872.1 - 0.7 10.3 3.8 4 7.9 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3795) PDEase_I PF00233.19 KII62873.1 - 1.3e-25 90.6 0.1 1.4e-25 90.4 0.1 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DDE_3 PF13358.6 KII62875.1 - 6.6e-16 58.4 0.0 1.3e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII62875.1 - 3.4e-06 26.7 0.0 5.8e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 KII62875.1 - 1.1e-05 25.0 0.3 3.2e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix HTH_24 PF13412.6 KII62875.1 - 2.6e-05 23.7 0.2 0.00012 21.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 KII62875.1 - 9.6e-05 22.2 0.0 0.00028 20.7 0.0 1.7 2 0 0 2 2 1 1 MarR family HTH_29 PF13551.6 KII62875.1 - 0.0001 22.2 0.0 0.00027 20.9 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 KII62875.1 - 0.00087 19.9 0.5 0.0014 19.2 0.0 1.6 2 0 0 2 2 1 1 Homeodomain-like domain PAX PF00292.18 KII62875.1 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_1_2 PF13022.6 KII62875.1 - 0.0032 17.6 0.7 0.089 13.0 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix of insertion element transposase MarR PF01047.22 KII62875.1 - 0.0037 17.2 0.1 0.028 14.3 0.1 2.4 2 0 0 2 2 2 1 MarR family CENP-B_N PF04218.13 KII62875.1 - 0.0042 16.7 0.4 0.011 15.4 0.0 1.8 2 0 0 2 2 1 1 CENP-B N-terminal DNA-binding domain DUF1323 PF07037.11 KII62875.1 - 0.0062 16.9 1.5 0.025 15.0 0.5 2.3 2 1 0 2 2 2 1 Putative transcription regulator (DUF1323) HTH_Crp_2 PF13545.6 KII62875.1 - 0.0066 16.4 0.2 0.017 15.1 0.2 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Fe_dep_repress PF01325.19 KII62875.1 - 0.0084 16.3 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain B5 PF03484.15 KII62875.1 - 0.0098 16.2 0.0 0.015 15.6 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase B5 domain Sigma70_r4 PF04545.16 KII62875.1 - 0.01 15.4 0.1 0.034 13.7 0.1 1.9 1 1 1 2 2 2 0 Sigma-70, region 4 HTH_28 PF13518.6 KII62875.1 - 0.012 15.8 0.0 0.047 13.8 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain TrmB PF01978.19 KII62875.1 - 0.014 15.3 0.0 0.042 13.7 0.0 1.8 2 0 0 2 2 1 0 Sugar-specific transcriptional regulator TrmB HTH_Tnp_Tc3_2 PF01498.18 KII62875.1 - 0.024 14.9 0.0 0.16 12.3 0.0 2.2 2 0 0 2 2 2 0 Transposase DUF4817 PF16087.5 KII62875.1 - 0.028 14.2 1.1 0.36 10.7 0.1 3.2 4 1 1 5 5 5 0 Helix-turn-helix domain (DUF4817) Dicer_dimer PF03368.14 KII62875.1 - 0.04 14.1 0.0 0.069 13.3 0.0 1.4 1 0 0 1 1 1 0 Dicer dimerisation domain HTH_36 PF13730.6 KII62875.1 - 0.041 13.8 0.0 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.6 KII62875.1 - 0.057 13.2 0.0 0.18 11.6 0.0 1.9 2 0 0 2 2 1 0 Helix-turn-helix domain EAP30 PF04157.16 KII62875.1 - 0.09 12.0 0.1 0.17 11.1 0.1 1.5 1 1 0 1 1 1 0 EAP30/Vps36 family Phage_CI_repr PF07022.13 KII62875.1 - 0.17 12.0 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain DDE_Tnp_IS1595 PF12762.7 KII62876.1 - 1.5e-16 60.8 0.0 2.5e-16 60.1 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain GDA1_CD39 PF01150.17 KII62879.1 - 6.8e-12 44.8 1.3 9.7e-12 44.3 1.3 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Tetraspanin PF00335.20 KII62879.1 - 0.66 9.6 3.8 0.28 10.9 0.6 2.0 2 1 0 2 2 2 0 Tetraspanin family ThiF PF00899.21 KII62881.1 - 9.6e-36 123.4 0.0 1.6e-35 122.6 0.0 1.3 1 0 0 1 1 1 1 ThiF family ATG7_N PF16420.5 KII62881.1 - 4.8e-08 33.0 0.0 8e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Shikimate_DH PF01488.20 KII62881.1 - 0.032 14.3 0.7 0.22 11.6 0.0 2.6 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 KII62881.1 - 0.14 12.6 0.0 0.97 9.9 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding Phage_stabilise PF11134.8 KII62883.1 - 0.11 11.3 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Phage stabilisation protein DUF4652 PF15525.6 KII62884.1 - 0.1 12.3 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4652) F_actin_cap_B PF01115.17 KII62885.1 - 3.5e-94 314.9 0.0 4.6e-94 314.5 0.0 1.2 1 0 0 1 1 1 1 F-actin capping protein, beta subunit CSTF2_hinge PF14327.6 KII62885.1 - 0.12 12.8 3.7 1.2 9.7 0.3 2.6 2 1 1 3 3 3 0 Hinge domain of cleavage stimulation factor subunit 2 Peptidase_S9 PF00326.21 KII62886.1 - 0.086 12.3 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Homeodomain PF00046.29 KII62887.1 - 2.3e-08 33.8 1.7 2.3e-08 33.8 1.7 1.8 2 0 0 2 2 2 1 Homeodomain DUF4162 PF13732.6 KII62887.1 - 0.17 12.6 1.7 0.27 12.0 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) Mso1_Sec1_bdg PF14475.6 KII62889.1 - 0.032 13.8 0.7 1 9.0 0.1 2.8 2 0 0 2 2 2 0 Sec1-binding region of Mso1 N6_Mtase PF02384.16 KII62891.1 - 0.00092 18.6 0.0 50 3.0 0.0 4.7 1 1 4 5 5 5 1 N-6 DNA Methylase DUF1324 PF07038.11 KII62891.1 - 0.014 15.6 10.7 55 4.1 0.1 5.6 5 0 0 5 5 5 0 Protein of unknown function (DUF1324) DUF4176 PF13780.6 KII62891.1 - 0.17 12.0 0.0 1.8e+02 2.3 0.0 3.8 2 1 4 6 6 6 0 Domain of unknown function (DUF4176) ydhR PF08803.11 KII62892.1 - 0.053 13.4 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Putative mono-oxygenase ydhR LIM PF00412.22 KII62893.1 - 0.038 14.2 0.0 0.073 13.3 0.0 1.5 1 0 0 1 1 1 0 LIM domain SNAP PF14938.6 KII62894.1 - 7.2e-07 28.9 6.6 9.3e-06 25.3 6.7 2.5 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 KII62894.1 - 0.00068 19.4 0.5 0.17 11.6 0.1 2.7 1 1 1 2 2 2 2 26S proteasome subunit RPN7 ANAPC3 PF12895.7 KII62894.1 - 0.036 14.3 0.1 0.13 12.5 0.1 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KII62894.1 - 0.083 13.2 3.4 8.9 6.7 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII62894.1 - 0.26 11.5 8.0 79 3.7 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII62894.1 - 3.4 8.1 8.6 2.5 8.5 0.0 4.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Sortilin-Vps10 PF15902.5 KII62897.1 - 6.4e-07 28.5 0.0 6.7e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII62897.1 - 0.15 12.1 2.4 0.43 10.8 0.6 2.4 2 0 0 2 2 2 0 BNR/Asp-box repeat AAA_assoc PF14363.6 KII62898.1 - 0.059 13.7 0.2 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 Domain associated at C-terminal with AAA Flu_B_NS1 PF02942.14 KII62899.1 - 0.19 10.8 0.0 0.23 10.5 0.0 1.1 1 0 0 1 1 1 0 Influenza B non-structural protein (NS1) DUF4318 PF14201.6 KII62901.1 - 0.072 13.6 0.1 0.14 12.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4318) PuR_N PF09182.10 KII62902.1 - 6.3e-12 45.3 6.3 4.6 7.3 0.1 8.0 1 1 9 10 10 10 10 Bacterial purine repressor, N-terminal EF-hand_10 PF14788.6 KII62902.1 - 3.4e-06 26.8 15.7 22 5.0 0.1 8.5 1 1 10 11 11 11 9 EF hand Ycf66_N PF07444.11 KII62902.1 - 0.0034 17.5 20.2 21 5.3 0.1 5.8 1 1 6 9 9 9 8 Ycf66 protein N-terminus SNAP PF14938.6 KII62905.1 - 6.7e-12 45.4 0.8 9.5e-12 44.9 0.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII62905.1 - 0.02 15.1 1.7 0.22 11.8 0.8 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII62905.1 - 0.029 14.5 2.6 5.7 7.3 0.4 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII62905.1 - 0.082 12.8 3.4 2.4 8.1 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KII62905.1 - 0.12 12.7 0.3 0.23 11.8 0.3 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat HTH_Tnp_Tc3_1 PF11427.8 KII62910.1 - 0.19 11.6 0.3 18 5.3 0.0 2.6 3 0 0 3 3 3 0 Tc3 transposase AAA_15 PF13175.6 KII62911.1 - 4.8e-20 72.6 13.6 9.1e-19 68.4 13.6 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KII62911.1 - 1.4e-18 67.8 0.1 8e-09 35.7 0.2 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KII62911.1 - 9.5e-16 58.9 3.0 1.7e-15 58.1 3.0 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 KII62911.1 - 4.1e-14 52.5 0.3 1.8e-13 50.5 0.3 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 KII62911.1 - 2e-07 31.6 0.0 6.4e-07 30.0 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 KII62911.1 - 3.2e-06 26.8 0.1 6.9e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF2813 PF11398.8 KII62911.1 - 3.4e-06 26.6 0.2 6.9e-06 25.6 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2813) AAA_13 PF13166.6 KII62911.1 - 0.00028 19.7 1.5 0.00052 18.8 1.5 1.5 1 1 0 1 1 1 1 AAA domain AAA_27 PF13514.6 KII62911.1 - 0.017 14.7 0.3 0.038 13.6 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KII62911.1 - 0.019 15.4 0.0 0.17 12.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KII62911.1 - 0.024 14.5 0.2 0.11 12.4 0.0 2.2 2 1 1 3 3 3 0 RsgA GTPase AAA_16 PF13191.6 KII62911.1 - 0.039 14.3 0.0 0.099 13.0 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 KII62911.1 - 0.077 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 KII62911.1 - 0.22 11.2 0.0 0.44 10.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain TSGA13 PF14994.6 KII62913.1 - 0.055 12.8 0.0 0.061 12.7 0.0 1.2 1 0 0 1 1 1 0 Testis-specific gene 13 protein LAS2 PF15792.5 KII62914.1 - 0.032 14.8 0.3 0.061 13.8 0.1 1.7 2 0 0 2 2 2 0 Lung adenoma susceptibility protein 2 PAF-AH_p_II PF03403.13 KII62914.1 - 0.052 12.0 0.4 0.057 11.9 0.4 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Fe_dep_repress PF01325.19 KII62914.1 - 0.14 12.4 0.4 0.21 11.8 0.4 1.4 1 1 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain DEAD PF00270.29 KII62915.1 - 4.4e-07 29.8 0.0 6.9e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KII62915.1 - 0.00058 19.9 1.0 0.0076 16.3 0.1 2.6 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KII62915.1 - 0.00074 19.9 0.0 0.0015 18.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 KII62915.1 - 0.0014 17.7 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ATPase PF06745.13 KII62915.1 - 0.0088 15.4 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 KaiC Zeta_toxin PF06414.12 KII62915.1 - 0.013 14.8 0.0 0.025 13.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.16 KII62915.1 - 0.014 14.8 0.0 0.048 13.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein ATPase_2 PF01637.18 KII62915.1 - 0.017 15.1 0.4 0.041 13.8 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea cobW PF02492.19 KII62915.1 - 0.023 14.3 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 KII62915.1 - 0.053 14.0 1.0 0.24 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 KII62915.1 - 0.059 13.4 0.0 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 KII62915.1 - 0.082 12.3 0.3 0.26 10.7 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein FtsK_SpoIIIE PF01580.18 KII62915.1 - 0.086 12.2 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Viral_helicase1 PF01443.18 KII62915.1 - 0.088 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Microtub_bd PF16796.5 KII62915.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Microtubule binding RsgA_GTPase PF03193.16 KII62915.1 - 0.12 12.2 0.0 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 KII62915.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain UvrD-helicase PF00580.21 KII62915.1 - 0.36 10.3 4.0 0.33 10.4 0.1 2.1 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_11 PF13086.6 KII62915.1 - 0.43 10.3 3.5 0.5 10.1 0.0 2.4 2 1 0 3 3 3 0 AAA domain Helicase_C PF00271.31 KII62916.1 - 4.5e-06 27.0 0.0 8e-06 26.2 0.0 1.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain CBM53 PF16760.5 KII62916.1 - 0.095 13.3 0.0 0.37 11.4 0.0 1.8 2 0 0 2 2 2 0 Starch/carbohydrate-binding module (family 53) PDZ PF00595.24 KII62918.1 - 2.1e-33 114.5 2.6 7.1e-15 55.1 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KII62918.1 - 3.1e-25 87.8 0.1 2.7e-11 43.2 0.0 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KII62918.1 - 1e-13 51.4 0.0 0.00033 20.9 0.0 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_4 PF17816.1 KII62918.1 - 6.2e-05 23.4 1.8 0.23 11.9 0.1 3.9 3 2 0 3 3 3 2 PDZ domain HLH PF00010.26 KII62919.1 - 0.024 14.6 0.8 0.051 13.5 0.8 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Urocanase_C PF17392.2 KII62919.1 - 0.03 13.8 0.1 0.045 13.2 0.1 1.2 1 0 0 1 1 1 0 Urocanase C-terminal domain Cullin PF00888.22 KII62921.1 - 1.3e-73 248.7 5.3 1.3e-73 248.7 5.3 1.9 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 KII62921.1 - 0.00039 20.4 0.1 0.0028 17.6 0.1 2.6 1 0 0 1 1 1 1 Cullin protein neddylation domain TFIIE_beta PF02186.15 KII62921.1 - 0.019 15.2 0.2 0.12 12.6 0.1 2.4 2 0 0 2 2 2 0 TFIIE beta subunit core domain EAL PF00563.20 KII62922.1 - 9.3e-25 87.5 0.0 1.3e-24 87.1 0.0 1.1 1 0 0 1 1 1 1 EAL domain PilZ PF07238.14 KII62923.1 - 0.00024 21.3 0.1 0.0016 18.7 0.1 2.3 2 1 0 2 2 2 1 PilZ domain Aldo_ket_red PF00248.21 KII62924.1 - 8e-16 58.1 0.0 8.9e-16 57.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PEN-2 PF10251.9 KII62925.1 - 0.0089 16.4 0.0 0.025 15.0 0.0 1.8 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase DUF5641 PF18701.1 KII62926.1 - 1.6e-08 34.6 0.1 3.2e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve PF00665.26 KII62926.1 - 0.0079 16.4 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain MVP_shoulder PF11978.8 KII62927.1 - 0.011 15.7 1.1 0.037 14.0 0.2 2.0 2 0 0 2 2 2 0 Shoulder domain SAPS PF04499.15 KII62929.1 - 6e-11 41.8 9.9 4.8e-07 28.9 1.9 3.2 2 1 1 4 4 4 2 SIT4 phosphatase-associated protein DUF89 PF01937.19 KII62930.1 - 8e-47 159.9 0.7 1.4e-46 159.0 0.7 1.4 1 1 0 1 1 1 1 Protein of unknown function DUF89 ATP-synt_C PF00137.21 KII62931.1 - 0.00024 21.4 14.1 0.00036 20.8 14.1 1.2 1 0 0 1 1 1 1 ATP synthase subunit C Integrase_H2C2 PF17921.1 KII62934.1 - 7.6e-05 22.7 0.9 0.00014 21.9 0.9 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain DUF4371 PF14291.6 KII62936.1 - 1.5e-12 47.7 0.1 1.5e-12 47.7 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) HTH_33 PF13592.6 KII62937.1 - 3.1e-07 29.9 0.0 4.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII62937.1 - 0.00031 20.9 0.0 0.00044 20.4 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_Tnp_1_2 PF13022.6 KII62937.1 - 0.0017 18.5 0.2 0.024 14.8 0.1 1.9 1 1 1 2 2 2 1 Helix-turn-helix of insertion element transposase B5 PF03484.15 KII62937.1 - 0.0019 18.5 0.0 0.0065 16.7 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetase B5 domain HTH_23 PF13384.6 KII62937.1 - 0.0028 17.4 0.1 3.4 7.6 0.1 2.5 2 1 0 2 2 2 2 Homeodomain-like domain DUF4637 PF15470.6 KII62937.1 - 0.052 13.3 0.0 0.068 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF2470 PF10615.9 KII62937.1 - 0.08 13.6 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) HTH_32 PF13565.6 KII62937.1 - 0.09 13.4 0.1 0.14 12.8 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DALR_2 PF09190.11 KII62937.1 - 0.44 11.0 1.9 1.4 9.5 0.7 2.3 1 1 0 1 1 1 0 DALR domain DDE_3 PF13358.6 KII62938.1 - 0.0062 16.3 0.1 0.0074 16.0 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease CRIC_ras_sig PF10534.9 KII62938.1 - 0.11 12.6 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras DegS PF05384.11 KII62943.1 - 0.02 14.4 1.6 0.031 13.8 1.6 1.2 1 0 0 1 1 1 0 Sensor protein DegS HTH_Tnp_Tc3_2 PF01498.18 KII62943.1 - 0.036 14.3 0.3 0.064 13.5 0.3 1.5 1 0 0 1 1 1 0 Transposase HTH_5 PF01022.20 KII62943.1 - 0.075 12.9 0.1 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family WYL_3 PF18488.1 KII62943.1 - 0.075 13.4 0.0 0.16 12.4 0.0 1.6 1 1 0 1 1 1 0 WYL domain DUF16 PF01519.16 KII62944.1 - 0.069 13.6 0.0 0.25 11.9 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 BRE1 PF08647.11 KII62944.1 - 0.096 12.8 0.8 0.47 10.5 0.3 2.1 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase zf-UBR PF02207.20 KII62947.1 - 2.3e-12 46.9 17.5 6e-12 45.6 17.5 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 KII62947.1 - 0.0062 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS RT_RNaseH PF17917.1 KII62948.1 - 3.9e-32 110.7 0.0 9.4e-32 109.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII62948.1 - 3.2e-31 107.3 0.0 7.3e-31 106.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII62948.1 - 2.7e-27 95.7 0.0 7.2e-27 94.3 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII62948.1 - 3.2e-27 95.1 0.0 1.2e-26 93.2 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII62948.1 - 8.4e-18 64.2 1.4 1.8e-17 63.1 1.4 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain MLVIN_C PF18697.1 KII62948.1 - 0.00019 21.5 0.0 0.00045 20.3 0.0 1.6 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII62948.1 - 0.00046 19.9 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Peptidase_S24 PF00717.23 KII62948.1 - 0.097 12.6 1.8 3.7 7.6 0.1 3.2 3 0 0 3 3 3 0 Peptidase S24-like CLASP_N PF12348.8 KII62950.1 - 0.036 13.6 0.0 0.34 10.4 0.0 2.0 2 0 0 2 2 2 0 CLASP N terminal Septin PF00735.18 KII62950.1 - 0.14 11.4 0.1 0.2 10.9 0.1 1.2 1 0 0 1 1 1 0 Septin Dynamin_M PF01031.20 KII62952.1 - 3.2e-31 108.6 0.0 5.1e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 KII62952.1 - 5.3e-18 65.6 0.1 9.2e-18 64.9 0.1 1.4 1 0 0 1 1 1 1 Dynamin family TMEM37 PF15108.6 KII62953.1 - 0.00052 19.9 0.2 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 Voltage-dependent calcium channel gamma-like subunit protein family PTP_tm PF18861.1 KII62953.1 - 0.0025 17.8 0.1 0.0032 17.5 0.1 1.2 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J Podoplanin PF05808.11 KII62953.1 - 0.0068 16.5 0.8 0.012 15.7 0.8 1.3 1 1 0 1 1 1 1 Podoplanin Orf78 PF06024.12 KII62953.1 - 0.012 15.9 0.6 0.022 15.1 0.3 1.6 1 1 1 2 2 2 0 Orf78 (ac78) YebO PF13974.6 KII62953.1 - 0.022 14.9 1.5 0.026 14.6 0.3 1.8 2 0 0 2 2 2 0 YebO-like protein Stevor PF17410.2 KII62953.1 - 0.032 13.8 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame VSP PF03302.13 KII62953.1 - 0.041 12.7 0.3 0.054 12.4 0.3 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein DUF3149 PF11346.8 KII62953.1 - 1.6 8.5 7.3 0.86 9.3 5.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3149) PTP_tm PF18861.1 KII62955.1 - 0.027 14.5 0.0 0.033 14.2 0.0 1.2 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Orf78 PF06024.12 KII62955.1 - 0.031 14.6 0.1 0.043 14.1 0.1 1.2 1 0 0 1 1 1 0 Orf78 (ac78) DUF3040 PF11239.8 KII62955.1 - 0.038 14.3 0.5 0.072 13.4 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF4328 PF14219.6 KII62955.1 - 0.076 12.6 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) BatD PF13584.6 KII62955.1 - 0.091 11.6 0.0 0.098 11.5 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance YebO PF13974.6 KII62955.1 - 0.11 12.6 1.3 0.23 11.5 0.4 1.9 2 0 0 2 2 2 0 YebO-like protein VSP PF03302.13 KII62955.1 - 0.31 9.8 0.1 0.36 9.6 0.1 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Podoplanin PF05808.11 KII62955.1 - 2 8.5 9.2 28 4.8 0.1 1.9 1 1 1 2 2 2 0 Podoplanin BUD22 PF09073.10 KII62957.1 - 0.12 11.7 9.3 0.15 11.4 9.3 1.0 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 KII62957.1 - 0.24 10.8 12.8 0.25 10.7 12.8 1.0 1 0 0 1 1 1 0 SDA1 Pes-10 PF07149.11 KII62957.1 - 0.47 9.5 8.2 0.58 9.2 8.2 1.2 1 0 0 1 1 1 0 Pes-10 Cwf_Cwc_15 PF04889.12 KII62957.1 - 1.5 8.5 15.0 2 8.1 15.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein KH_1 PF00013.29 KII62959.1 - 6.7e-05 22.6 0.0 9.9e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 KII62959.1 - 0.016 15.0 0.1 0.027 14.3 0.1 1.4 1 1 0 1 1 1 0 KH domain HTH_32 PF13565.6 KII62960.1 - 0.0075 16.9 0.6 0.013 16.1 0.6 1.4 1 0 0 1 1 1 1 Homeodomain-like domain DDE_3 PF13358.6 KII62960.1 - 0.065 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease Sugar_tr PF00083.24 KII62962.1 - 1.1e-53 182.7 30.6 1.4e-53 182.4 30.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII62962.1 - 5.6e-20 71.6 20.8 5.6e-20 71.6 20.8 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_4 PF06779.14 KII62962.1 - 0.0005 19.5 3.6 0.0014 18.0 3.5 1.7 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB Fst_toxin PF13955.6 KII62962.1 - 0.21 11.5 0.0 0.21 11.5 0.0 2.9 3 0 0 3 3 3 0 Toxin Fst, type I toxin-antitoxin system DDE_3 PF13358.6 KII62963.1 - 0.00017 21.4 0.1 0.00066 19.5 0.1 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease Peptidase_M3 PF01432.20 KII62964.1 - 1.1e-43 150.2 1.2 1.5e-43 149.8 1.2 1.0 1 0 0 1 1 1 1 Peptidase family M3 Ribosom_S30AE_C PF16321.5 KII62964.1 - 0.099 12.4 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus Skp1_POZ PF03931.15 KII62966.1 - 8.8e-08 32.2 0.0 2e-07 31.1 0.0 1.5 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain CRR7 PF12095.8 KII62966.1 - 0.11 12.9 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein CHLORORESPIRATORY REDUCTION 7 NOB1_Zn_bind PF08772.11 KII62968.1 - 2.2e-11 43.8 1.4 2.2e-11 43.8 1.4 1.7 1 1 1 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.6 KII62968.1 - 0.0017 18.0 1.6 0.0033 17.1 1.6 1.5 1 0 0 1 1 1 1 zinc-ribbon domain Cript PF10235.9 KII62968.1 - 0.062 13.9 2.5 0.21 12.2 0.4 2.2 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT Me-amine-dh_H PF06433.11 KII62968.1 - 0.092 11.6 0.1 0.1 11.4 0.1 1.3 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) zf-C4_ClpX PF06689.13 KII62968.1 - 0.6 10.0 3.1 8.4 6.4 0.8 2.3 2 0 0 2 2 2 0 ClpX C4-type zinc finger DUF4634 PF15465.6 KII62969.1 - 0.065 13.5 1.4 0.09 13.1 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4634) DNA_ligase_A_N PF04675.14 KII62970.1 - 0.027 14.8 0.0 0.036 14.4 0.0 1.2 1 0 0 1 1 1 0 DNA ligase N terminus TMEM71 PF15121.6 KII62970.1 - 0.062 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 TMEM71 protein family Ras PF00071.22 KII62971.1 - 0.0092 15.6 0.1 0.021 14.4 0.0 1.5 1 1 1 2 2 2 1 Ras family PsaF PF17550.2 KII62971.1 - 0.011 15.3 0.4 0.014 14.9 0.4 1.1 1 0 0 1 1 1 0 Family of unknown function EF_assoc_2 PF08356.12 KII62972.1 - 7.8e-08 32.2 0.0 7e-07 29.2 0.0 2.1 2 0 0 2 2 2 1 EF hand associated EF-hand_6 PF13405.6 KII62972.1 - 8.4e-06 25.3 1.7 4.7e-05 23.0 0.8 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KII62972.1 - 1.3e-05 25.5 0.8 3.5e-05 24.1 0.8 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KII62972.1 - 8.4e-05 21.9 3.8 0.00022 20.5 1.1 2.7 2 1 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KII62972.1 - 0.00017 20.9 2.0 0.0036 16.7 1.4 3.2 3 1 1 4 4 4 1 EF hand Caleosin PF05042.13 KII62972.1 - 0.046 13.7 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 Caleosin related protein EF-hand_8 PF13833.6 KII62972.1 - 0.05 13.5 1.0 3.2 7.7 0.2 2.4 2 0 0 2 2 2 0 EF-hand domain pair Ras PF00071.22 KII62973.1 - 9.2e-06 25.4 0.7 9.5e-05 22.0 0.7 2.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KII62973.1 - 0.00054 20.2 0.1 0.0058 16.8 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KII62973.1 - 0.006 16.6 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KII62973.1 - 0.0079 16.1 0.1 1.2 9.1 0.0 2.4 2 1 0 2 2 2 1 RsgA GTPase AAA PF00004.29 KII62973.1 - 0.011 16.2 0.0 0.02 15.3 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII62973.1 - 0.019 15.4 0.0 0.026 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 KII62973.1 - 0.035 13.8 0.2 0.11 12.2 0.1 1.8 1 1 1 2 2 2 0 AAA domain PduV-EutP PF10662.9 KII62973.1 - 0.058 13.2 0.3 0.49 10.1 0.3 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KII62973.1 - 0.07 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 KII62973.1 - 0.077 12.6 0.1 0.2 11.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KII62973.1 - 0.094 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 KII62973.1 - 0.1 12.8 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KII62973.1 - 0.21 12.1 0.0 0.32 11.5 0.0 1.4 1 1 0 1 1 1 0 ABC transporter TIP49 PF06068.13 KII62973.1 - 0.25 10.5 1.3 1.5 7.9 0.1 2.4 1 1 1 3 3 3 0 TIP49 P-loop domain DUF3070 PF11270.8 KII62973.1 - 0.73 10.1 2.6 1.9 8.8 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3070) FGGY_C PF02782.16 KII62975.1 - 0.00037 20.3 0.0 0.0007 19.4 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Ribosomal_L14 PF00238.19 KII62976.1 - 1e-32 112.8 1.5 1.3e-32 112.5 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Pkinase PF00069.25 KII62977.1 - 3.7e-16 59.3 0.0 4.2e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII62977.1 - 1.8e-07 30.7 0.0 2.1e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 KII62978.1 - 2.9e-16 59.0 0.0 5.2e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KII62978.1 - 0.00035 20.2 0.0 0.00039 20.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GST_C_2 PF13410.6 KII62980.1 - 7e-09 35.6 0.0 1.1e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KII62980.1 - 5.5e-05 23.3 0.0 0.00011 22.3 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KII62980.1 - 0.00046 20.3 0.0 0.001 19.2 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KII62980.1 - 0.0014 19.0 0.0 0.003 17.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 KII62980.1 - 0.0088 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KII62980.1 - 0.037 14.4 0.0 0.13 12.6 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 KII62980.1 - 0.05 14.2 0.0 0.081 13.5 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF4371 PF14291.6 KII62981.1 - 2.6e-05 24.0 0.1 3.3e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) rve PF00665.26 KII62983.1 - 9.3e-15 54.9 0.0 1.4e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII62983.1 - 0.0002 21.1 0.1 0.00054 19.7 0.1 1.9 2 1 0 2 2 2 1 Integrase core domain PCO_ADO PF07847.12 KII62984.1 - 1.4e-29 103.0 0.1 1.6e-29 102.8 0.1 1.1 1 0 0 1 1 1 1 PCO_ADO CDO_I PF05995.12 KII62984.1 - 0.033 13.5 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Cysteine dioxygenase type I DUF1971 PF09313.11 KII62984.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1971) Histone PF00125.24 KII62986.1 - 4.4e-51 172.7 4.2 4.9e-51 172.5 4.2 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 KII62986.1 - 2.4e-05 25.0 0.8 2.5e-05 24.9 0.8 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 KII62986.1 - 3e-05 24.1 0.8 4.1e-05 23.6 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KII62986.1 - 0.00049 20.4 0.0 0.00076 19.8 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KII62986.1 - 0.0091 16.3 0.0 0.0091 16.3 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KII62986.1 - 0.024 14.7 0.3 0.039 14.0 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Actin PF00022.19 KII62988.1 - 3.2e-90 302.7 0.0 4.4e-53 180.4 0.0 2.0 1 1 1 2 2 2 2 Actin FtsA PF14450.6 KII62988.1 - 0.0028 18.0 0.0 0.015 15.7 0.0 2.2 1 1 0 1 1 1 1 Cell division protein FtsA KilA-N PF04383.13 KII62988.1 - 0.083 12.7 0.0 2.2 8.2 0.0 2.5 2 0 0 2 2 2 0 KilA-N domain Snf7 PF03357.21 KII62989.1 - 3e-11 43.2 8.7 3.5e-11 43.0 8.7 1.0 1 0 0 1 1 1 1 Snf7 CCDC66 PF15236.6 KII62989.1 - 0.023 14.5 5.3 0.026 14.4 5.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 Macoilin PF09726.9 KII62989.1 - 0.06 11.9 2.5 0.064 11.8 2.5 1.1 1 0 0 1 1 1 0 Macoilin family APG6_N PF17675.1 KII62989.1 - 0.14 12.7 3.6 0.19 12.3 3.6 1.3 1 1 0 1 1 1 0 Apg6 coiled-coil region Peptidase_C54 PF03416.19 KII62990.1 - 7.5e-25 87.9 0.0 8.7e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 KII62990.1 - 0.0022 17.5 0.1 0.0034 16.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 KII62991.1 - 3.6e-21 75.8 0.0 4.2e-21 75.6 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 Dimer_Tnp_hAT PF05699.14 KII62992.1 - 0.061 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region Lig_C PF18330.1 KII62993.1 - 0.074 13.1 1.0 0.098 12.7 1.0 1.2 1 0 0 1 1 1 0 Ligase Pab1020 C-terminal region SWIB PF02201.18 KII62994.1 - 1.2e-14 54.0 0.0 2.3e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain ZapB PF06005.12 KII62994.1 - 0.041 14.3 0.0 0.084 13.3 0.0 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF2154 PF09922.9 KII62995.1 - 0.045 13.6 1.0 0.045 13.6 1.0 2.1 2 1 0 2 2 2 0 Cell wall-active antibiotics response 4TMS YvqF EGF_2 PF07974.13 KII62997.1 - 0.1 13.0 37.2 0.63 10.5 10.3 3.9 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.7 KII62997.1 - 4.5 8.1 22.1 0.39 11.4 4.7 4.6 3 1 0 3 3 3 0 Human growth factor-like EGF Serpin PF00079.20 KII63000.1 - 2.7e-31 109.2 3.0 3.3e-31 108.9 3.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Patatin PF01734.22 KII63001.1 - 0.0014 18.8 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase GLEYA PF10528.9 KII63001.1 - 0.043 14.2 0.0 0.071 13.5 0.0 1.4 1 0 0 1 1 1 0 GLEYA domain PRANC PF09372.10 KII63002.1 - 8.9e-05 22.7 6.2 0.019 15.3 0.4 3.5 3 0 0 3 3 3 2 PRANC domain Defensin_3 PF08131.11 KII63002.1 - 0.035 14.3 0.5 0.089 13.0 0.5 1.7 1 0 0 1 1 1 0 Defensin-like peptide family Sortilin-Vps10 PF15902.5 KII63004.1 - 4.9e-09 35.5 0.5 1e-08 34.5 0.5 1.4 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII63004.1 - 0.093 12.8 4.9 9.4 6.7 0.0 3.7 3 0 0 3 3 3 0 BNR/Asp-box repeat BNR PF02012.20 KII63005.1 - 2e-09 36.0 3.5 0.033 14.1 0.1 4.2 4 0 0 4 4 4 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII63005.1 - 3.5e-09 36.0 0.5 7.4e-09 34.9 0.5 1.5 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Mo-co_dimer PF03404.16 KII63005.1 - 0.15 12.0 0.3 31 4.6 0.0 3.3 3 1 1 4 4 4 0 Mo-co oxidoreductase dimerisation domain DUF202 PF02656.15 KII63006.1 - 0.049 14.1 4.9 0.82 10.2 4.9 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Flu_NS2 PF00601.19 KII63007.1 - 0.051 13.9 1.3 1.9 8.9 0.1 2.6 2 1 0 2 2 2 0 Influenza non-structural protein (NS2) DDE_1 PF03184.19 KII63009.1 - 6.2e-12 45.5 0.0 9.9e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Ribosomal_L13e PF01294.18 KII63010.1 - 2.3e-68 229.6 2.1 3e-68 229.2 2.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Herpes_LP PF03363.13 KII63010.1 - 0.084 12.7 0.4 0.14 12.0 0.4 1.3 1 0 0 1 1 1 0 Herpesvirus leader protein Ribosomal_L13e PF01294.18 KII63011.1 - 2.3e-68 229.6 2.1 3e-68 229.2 2.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Herpes_LP PF03363.13 KII63011.1 - 0.084 12.7 0.4 0.14 12.0 0.4 1.3 1 0 0 1 1 1 0 Herpesvirus leader protein TPR_14 PF13428.6 KII63012.1 - 2.3e-14 52.8 0.0 1.7 9.7 0.0 10.4 9 2 3 12 12 11 2 Tetratricopeptide repeat NRDE-2 PF08424.10 KII63012.1 - 2.1e-07 30.4 14.4 0.00029 20.1 0.2 5.8 4 3 1 5 5 5 3 NRDE-2, necessary for RNA interference TPR_15 PF13429.6 KII63012.1 - 2.7e-07 30.1 0.0 0.011 15.0 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KII63012.1 - 6.9e-06 26.3 0.7 0.26 11.6 0.1 5.2 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII63012.1 - 3e-05 23.9 4.6 1.9 8.9 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KII63012.1 - 4.5e-05 23.4 16.0 0.11 12.5 0.0 7.7 7 2 0 8 8 8 2 Mad3/BUB1 homology region 1 RPN7 PF10602.9 KII63012.1 - 0.00024 20.8 0.1 0.36 10.5 0.0 2.9 2 0 0 2 2 2 2 26S proteasome subunit RPN7 TPR_19 PF14559.6 KII63012.1 - 0.0021 18.5 0.0 0.66 10.5 0.0 4.4 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 KII63012.1 - 0.0046 17.2 7.9 6.9 7.3 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 KII63012.1 - 0.027 14.6 12.5 0.72 10.1 0.1 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII63012.1 - 0.94 9.4 4.6 3.1 7.8 0.2 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Wyosine_form PF08608.12 KII63013.1 - 1.2e-20 73.6 0.3 2.3e-20 72.7 0.3 1.5 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 KII63013.1 - 1.1e-17 65.0 0.0 1.9e-17 64.2 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily PurA PF04845.13 KII63013.1 - 0.053 12.9 0.0 0.073 12.4 0.0 1.2 1 0 0 1 1 1 0 PurA ssDNA and RNA-binding protein Ldl_recept_a PF00057.18 KII63015.1 - 1.6e-19 69.8 31.4 3.2e-11 43.2 10.1 2.5 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A zf-CCHC PF00098.23 KII63016.1 - 0.029 14.4 0.3 0.029 14.4 0.3 2.5 2 1 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII63016.1 - 0.042 13.6 2.2 0.042 13.6 2.2 2.5 1 1 1 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 KII63018.1 - 1.6e-32 111.5 0.0 2.7e-32 110.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63018.1 - 5.2e-31 107.1 0.0 9e-31 106.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII63018.1 - 0.021 14.3 0.1 0.043 13.3 0.1 1.6 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII63019.1 - 2e-21 76.4 0.3 2.6e-21 76.0 0.3 1.1 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63019.1 - 0.0075 16.4 0.8 0.048 13.8 0.4 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII63019.1 - 0.0088 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain HTH_23 PF13384.6 KII63021.1 - 4.2e-07 29.6 0.0 9.5e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 KII63021.1 - 1e-06 28.6 0.0 1.5e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 KII63021.1 - 3e-06 27.3 0.0 5.2e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 KII63021.1 - 3.3e-06 26.8 0.0 0.0002 21.0 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.15 KII63021.1 - 0.00058 19.9 0.4 0.0038 17.3 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase PAX PF00292.18 KII63021.1 - 0.00099 19.0 0.0 0.001 19.0 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.16 KII63021.1 - 0.011 15.7 0.1 0.014 15.5 0.1 1.1 1 0 0 1 1 1 0 Transposase HTH_11 PF08279.12 KII63021.1 - 0.012 15.6 0.2 0.018 15.0 0.2 1.3 1 0 0 1 1 1 0 HTH domain HTH_Crp_2 PF13545.6 KII63021.1 - 0.014 15.3 0.1 0.031 14.3 0.0 1.5 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain HTH_32 PF13565.6 KII63021.1 - 0.047 14.3 0.0 0.58 10.8 0.0 2.0 1 1 1 2 2 2 0 Homeodomain-like domain TrmB PF01978.19 KII63021.1 - 0.062 13.2 0.1 0.093 12.6 0.1 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sigma70_r4 PF04545.16 KII63021.1 - 0.086 12.4 0.0 0.36 10.4 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 MarR PF01047.22 KII63021.1 - 0.14 12.1 0.1 0.55 10.2 0.1 1.9 1 1 0 1 1 1 0 MarR family Sigma70_r4_2 PF08281.12 KII63021.1 - 0.21 11.3 0.1 0.63 9.8 0.0 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 PWWP PF00855.17 KII63023.1 - 0.036 14.5 0.1 0.042 14.3 0.1 1.2 1 0 0 1 1 1 0 PWWP domain IF-2B PF01008.17 KII63026.1 - 4.6e-40 137.6 0.0 6.3e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family zf-Sec23_Sec24 PF04810.15 KII63027.1 - 0.026 14.6 1.9 0.065 13.3 1.9 1.7 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger FLYWCH PF04500.16 KII63028.1 - 3.7e-10 39.8 0.3 8.3e-10 38.6 0.3 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII63028.1 - 0.00072 19.9 0.1 0.0014 19.0 0.1 1.5 1 0 0 1 1 1 1 MULE transposase domain H_lectin PF09458.10 KII63028.1 - 0.12 12.6 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 H-type lectin domain Serpin PF00079.20 KII63029.1 - 2.6e-31 109.3 0.5 1.3e-18 67.5 0.1 2.1 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) rve PF00665.26 KII63030.1 - 5.7e-09 36.2 0.0 9.3e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63030.1 - 0.039 14.0 0.2 0.082 13.0 0.2 1.6 1 0 0 1 1 1 0 Integrase zinc binding domain RVT_1 PF00078.27 KII63031.1 - 3.1e-31 108.6 0.1 3.9e-31 108.3 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Serpin PF00079.20 KII63032.1 - 2.2e-44 152.3 3.5 2.5e-44 152.1 3.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII63033.1 - 8.7e-37 127.3 3.7 1.6e-36 126.5 3.7 1.4 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Imm42 PF15593.6 KII63033.1 - 0.0068 16.9 2.8 0.026 15.0 2.5 2.0 2 0 0 2 2 2 1 Immunity protein 42 Gp_UL130 PF11668.8 KII63033.1 - 0.062 13.2 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 HCMV glycoprotein pUL130 Serpin PF00079.20 KII63034.1 - 1.5e-17 64.0 0.0 1.7e-17 63.8 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII63035.1 - 2.8e-41 142.0 2.1 3.2e-41 141.9 2.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII63036.1 - 3.8e-51 174.5 6.6 4.4e-51 174.3 6.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII63037.1 - 6.6e-50 170.5 5.4 6.8e-49 167.1 5.4 1.9 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_3 PF13358.6 KII63038.1 - 1.1e-28 99.8 0.0 1.5e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RapH_N PF18801.1 KII63038.1 - 0.1 12.7 0.2 3 8.0 0.0 2.5 2 0 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal Baculo_ODV-E27 PF05314.11 KII63038.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 Serpin PF00079.20 KII63039.1 - 1.7e-12 47.3 0.2 1.8e-12 47.2 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII63040.1 - 1.5e-40 139.7 3.0 1.8e-40 139.4 3.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) HNHc_6 PF16784.5 KII63040.1 - 0.0044 16.6 0.0 0.018 14.6 0.0 2.0 3 0 0 3 3 3 1 Putative HNHc nuclease PSI PF01437.25 KII63041.1 - 0.00019 21.9 2.2 0.00025 21.5 2.2 1.2 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.3 KII63041.1 - 0.0032 17.2 2.7 0.0047 16.6 2.7 1.3 1 0 0 1 1 1 1 Integrin plexin domain Jiraiya PF15038.6 KII63042.1 - 0.057 12.8 1.2 0.066 12.6 1.2 1.1 1 0 0 1 1 1 0 Jiraiya Thioredoxin PF00085.20 KII63044.1 - 3.2e-28 97.7 0.1 9.5e-23 80.1 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin OST3_OST6 PF04756.13 KII63044.1 - 3.4e-08 33.2 0.7 2.6e-06 27.0 0.0 2.2 1 1 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 KII63044.1 - 1.1e-06 28.8 0.9 4.7e-05 23.4 0.1 2.9 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 KII63044.1 - 9.2e-05 22.9 0.2 0.0073 16.7 0.0 2.7 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KII63044.1 - 0.0017 18.7 0.7 6.1 7.3 0.0 4.0 3 2 0 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.6 KII63044.1 - 0.035 14.3 0.1 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like HyaE PF07449.11 KII63044.1 - 0.07 13.1 0.0 18 5.3 0.0 3.2 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE EDR1 PF14381.6 KII63044.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 CxC4 PF18717.1 KII63046.1 - 0.006 16.4 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 2 CxC4 like cysteine cluster associated with KDZ transposases AAA_23 PF13476.6 KII63046.1 - 0.034 14.6 0.0 0.049 14.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Integrin_beta PF00362.18 KII63047.1 - 3e-14 53.3 0.0 3.2e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Integrin beta chain VWA domain Anp1 PF03452.14 KII63047.1 - 0.069 12.6 0.0 0.071 12.5 0.0 1.1 1 0 0 1 1 1 0 Anp1 U-box PF04564.15 KII63047.1 - 0.19 11.9 0.0 0.34 11.1 0.0 1.3 1 0 0 1 1 1 0 U-box domain PSI_integrin PF17205.3 KII63048.1 - 0.044 13.5 1.7 0.058 13.1 0.6 1.8 2 0 0 2 2 2 0 Integrin plexin domain PSI PF01437.25 KII63048.1 - 0.23 12.1 5.6 0.48 11.0 5.6 1.7 1 1 0 1 1 1 0 Plexin repeat EGF_2 PF07974.13 KII63049.1 - 3.9e-08 33.5 55.7 0.0011 19.3 14.0 3.7 3 0 0 3 3 3 3 EGF-like domain Integrin_beta PF00362.18 KII63049.1 - 0.00049 19.8 0.1 0.7 9.5 0.0 2.4 1 1 0 2 2 2 2 Integrin beta chain VWA domain EGF_Tenascin PF18720.1 KII63049.1 - 0.0074 16.3 7.6 0.0074 16.3 7.6 3.5 3 0 0 3 3 3 1 Tenascin EGF domain I-EGF_1 PF18372.1 KII63049.1 - 0.009 16.1 8.4 0.009 16.1 8.4 4.3 4 0 0 4 4 4 2 Integrin beta epidermal growth factor like domain 1 STOP PF05217.12 KII63049.1 - 0.41 11.0 33.7 0.55 10.6 4.8 4.1 4 0 0 4 4 4 0 STOP protein Ovate PF04844.13 KII63050.1 - 0.055 13.5 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Transcriptional repressor, ovate Kelch_6 PF13964.6 KII63052.1 - 1.4e-07 31.5 1.7 2.3e-05 24.5 0.0 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 KII63052.1 - 5.3e-06 25.9 1.8 3.3e-05 23.4 0.0 2.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 KII63052.1 - 5.6e-05 23.1 1.7 0.0007 19.6 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 KII63052.1 - 0.00085 19.6 0.9 0.022 15.1 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 KII63052.1 - 0.0024 17.8 0.7 0.008 16.1 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 KII63052.1 - 0.0024 17.8 1.7 0.0096 15.9 0.2 2.3 2 0 0 2 2 2 1 Kelch motif DDE_Tnp_IS1595 PF12762.7 KII63054.1 - 0.0038 17.2 0.0 0.005 16.9 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Kelch_6 PF13964.6 KII63055.1 - 6.5e-24 83.4 13.7 2.7e-05 24.3 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KII63055.1 - 2.5e-16 59.4 13.9 0.0021 18.0 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII63055.1 - 2.5e-16 59.0 11.2 5.7e-05 22.6 0.0 6.6 6 1 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII63055.1 - 2.4e-14 53.2 11.2 0.00012 22.2 0.2 7.0 5 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII63055.1 - 1.6e-08 34.3 10.2 0.045 13.7 0.1 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 KII63055.1 - 2.9e-08 33.4 17.5 0.049 13.6 0.0 6.5 6 1 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KII63056.1 - 6e-25 86.7 14.6 7.7e-07 29.2 0.0 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.25 KII63056.1 - 1.8e-19 69.0 12.9 0.00058 19.4 0.2 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII63056.1 - 1.2e-15 57.3 14.5 0.0015 18.5 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KII63056.1 - 5e-15 55.1 14.8 0.00014 21.7 0.1 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII63056.1 - 1.1e-12 47.8 15.2 0.0028 17.9 0.0 7.5 6 1 1 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII63056.1 - 1.1e-09 37.9 12.0 0.32 11.0 0.2 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KII63057.1 - 2.5e-25 87.9 17.4 2.6e-07 30.7 0.1 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KII63057.1 - 4.4e-22 77.4 10.0 2.2e-07 30.4 0.2 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII63057.1 - 1e-15 57.4 19.3 0.00065 19.7 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KII63057.1 - 1.2e-15 57.4 10.9 4.1e-06 26.9 0.0 6.2 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII63057.1 - 1e-09 38.1 15.0 3.4e-05 23.7 0.0 5.4 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 KII63057.1 - 2e-09 37.1 13.2 0.00093 19.1 0.1 5.9 6 0 0 6 6 6 3 Kelch motif DUF4256 PF14066.6 KII63057.1 - 0.23 11.1 1.6 5.9 6.5 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4256) DUF5638 PF18688.1 KII63058.1 - 0.23 11.8 4.8 0.41 11.0 0.1 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5638) DUF3425 PF11905.8 KII63060.1 - 0.046 13.7 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3425) Orthoreo_P17 PF07272.11 KII63060.1 - 0.05 13.6 0.1 0.058 13.4 0.1 1.2 1 0 0 1 1 1 0 Orthoreovirus P17 protein Par3_HAL_N_term PF12053.8 KII63060.1 - 0.075 13.3 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 N-terminal of Par3 and HAL proteins DDE_3 PF13358.6 KII63062.1 - 7.7e-06 25.7 0.1 1.5e-05 24.8 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII63062.1 - 0.018 14.7 0.7 0.024 14.3 0.0 1.5 2 0 0 2 2 2 0 Winged helix-turn helix XPG_N PF00752.17 KII63064.1 - 2.3e-22 79.4 0.0 4.9e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KII63064.1 - 2.2e-19 69.6 1.5 2.3e-19 69.5 0.4 1.7 2 0 0 2 2 2 1 XPG I-region XPG_I_2 PF12813.7 KII63064.1 - 4.7e-05 23.0 0.1 6.9e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 KII63064.1 - 0.15 12.6 0.0 0.36 11.5 0.0 1.6 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Ldl_recept_a PF00057.18 KII63067.1 - 1.3e-05 25.4 14.0 1.3e-05 25.4 14.0 3.7 4 2 1 5 5 5 1 Low-density lipoprotein receptor domain class A PS_pyruv_trans PF04230.13 KII63067.1 - 0.024 14.5 0.2 0.039 13.9 0.2 1.3 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase Sortilin_C PF15901.5 KII63068.1 - 5.2e-15 56.2 1.6 9.4e-15 55.4 1.6 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII63068.1 - 3.9e-14 52.3 0.0 0.00015 20.7 0.0 3.1 3 0 0 3 3 3 3 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII63068.1 - 0.00048 19.7 15.8 2.5 8.5 0.1 5.8 5 0 0 5 5 5 4 BNR/Asp-box repeat CHB_HEX_C PF03174.13 KII63068.1 - 0.0017 18.3 0.3 29 4.7 0.0 4.3 4 1 1 5 5 5 1 Chitobiase/beta-hexosaminidase C-terminal domain DDE_Tnp_IS1595 PF12762.7 KII63070.1 - 9.6e-11 41.9 0.1 5.2e-10 39.5 0.1 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain UPA PF17217.3 KII63070.1 - 0.058 13.3 1.0 0.1 12.5 1.0 1.4 1 0 0 1 1 1 0 UPA domain zf-C3HC4_3 PF13920.6 KII63070.1 - 1.4 8.8 7.4 0.46 10.4 1.5 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) BCIP PF13862.6 KII63072.1 - 0.099 12.4 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 p21-C-terminal region-binding protein Sortilin-Vps10 PF15902.5 KII63073.1 - 2.8e-06 26.4 0.5 8.1e-05 21.6 0.0 2.5 1 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII63073.1 - 0.12 12.4 11.3 1.3 9.3 0.1 3.6 3 0 0 3 3 3 0 BNR/Asp-box repeat Ldl_recept_a PF00057.18 KII63074.1 - 4.7e-06 26.7 11.6 4.7e-06 26.7 11.6 3.2 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A PS_pyruv_trans PF04230.13 KII63074.1 - 0.031 14.2 0.1 0.054 13.4 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase Ldl_recept_a PF00057.18 KII63075.1 - 4.7e-08 33.1 12.2 4.7e-08 33.1 12.2 2.4 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A zf-C2H2_8 PF15909.5 KII63077.1 - 0.0056 17.0 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 C2H2-type zinc ribbon HTH_Tnp_IS630 PF01710.16 KII63078.1 - 0.0013 18.8 0.5 0.0015 18.6 0.5 1.2 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc3_2 PF01498.18 KII63078.1 - 0.0069 16.6 0.1 0.016 15.5 0.1 1.5 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 KII63078.1 - 0.011 16.3 0.1 0.016 15.8 0.1 1.3 1 1 0 1 1 1 0 Homeodomain-like domain HTH_23 PF13384.6 KII63078.1 - 0.041 13.7 0.1 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain PAX PF00292.18 KII63078.1 - 0.072 13.0 0.0 0.079 12.9 0.0 1.1 1 0 0 1 1 1 0 'Paired box' domain Fer2_BFD PF04324.15 KII63078.1 - 0.16 12.4 0.1 0.72 10.3 0.0 2.1 1 1 1 2 2 2 0 BFD-like [2Fe-2S] binding domain HTH_psq PF05225.16 KII63078.1 - 0.17 11.6 0.2 0.55 10.0 0.0 1.9 2 0 0 2 2 2 0 helix-turn-helix, Psq domain Peptidase_M73 PF12389.8 KII63079.1 - 0.021 14.6 0.1 0.039 13.8 0.1 1.5 1 0 0 1 1 1 0 Camelysin metallo-endopeptidase WASH_WAHD PF11945.8 KII63080.1 - 0.001 18.7 1.0 0.0019 17.8 0.1 1.9 2 0 0 2 2 2 1 WAHD domain of WASH complex ABC_tran_CTD PF16326.5 KII63080.1 - 0.0059 16.8 0.0 0.021 15.1 0.0 2.0 1 0 0 1 1 1 1 ABC transporter C-terminal domain Rx_N PF18052.1 KII63080.1 - 0.011 16.0 0.3 3.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Rx N-terminal domain PLU-1 PF08429.11 KII63080.1 - 0.029 13.6 4.0 0.047 12.9 0.7 2.2 2 0 0 2 2 2 0 PLU-1-like protein CdvA PF18822.1 KII63080.1 - 0.035 13.9 3.3 0.17 11.7 0.1 2.7 3 0 0 3 3 3 0 CdvA-like coiled-coil domain Prefoldin PF02996.17 KII63080.1 - 0.077 12.9 2.8 0.16 11.9 0.2 2.6 2 1 0 2 2 2 0 Prefoldin subunit DUF4988 PF16378.5 KII63080.1 - 0.11 12.1 1.9 0.91 9.2 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function Prefoldin_2 PF01920.20 KII63080.1 - 0.15 12.0 0.2 0.15 12.0 0.2 2.4 3 0 0 3 3 3 0 Prefoldin subunit P4Ha_N PF08336.11 KII63080.1 - 0.23 11.5 1.8 1.2 9.2 0.1 2.7 2 1 1 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF5082 PF16888.5 KII63080.1 - 0.25 11.6 0.2 0.25 11.6 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) YkyA PF10368.9 KII63080.1 - 8.6 6.0 11.0 0.9 9.2 1.3 3.1 3 1 1 4 4 4 0 Putative cell-wall binding lipoprotein Clat_adaptor_s PF01217.20 KII63082.1 - 0.00054 19.9 0.2 0.00063 19.7 0.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TPR_1 PF00515.28 KII63083.1 - 7.5e-07 28.7 0.3 0.0018 18.0 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII63083.1 - 1.2e-05 25.1 0.1 0.15 12.3 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII63083.1 - 0.0002 21.3 0.3 0.1 12.8 0.2 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KII63083.1 - 0.004 17.4 1.2 0.08 13.2 1.2 2.0 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 KII63083.1 - 0.01 15.5 0.1 5.6 6.7 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_10 PF13374.6 KII63083.1 - 0.15 11.9 0.5 2.6 8.1 0.2 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 KII63084.1 - 6.9e-05 22.5 0.0 0.00055 19.6 0.0 2.4 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 KII63084.1 - 0.00013 21.8 0.0 0.26 11.5 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KII63084.1 - 0.00033 20.4 0.0 0.075 12.9 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII63084.1 - 0.077 13.3 0.0 2.1 8.8 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KII63085.1 - 0.0004 20.5 0.7 0.001 19.3 0.7 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 HTH_33 PF13592.6 KII63086.1 - 0.11 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix DUF2315 PF10231.9 KII63088.1 - 8.6e-16 58.2 3.1 1e-15 57.9 3.1 1.1 1 0 0 1 1 1 1 Apoptogenic protein 1 ADAM_CR PF08516.12 KII63089.1 - 2.7e-14 53.5 11.4 2.7e-14 53.5 11.4 3.2 3 0 0 3 3 3 2 ADAM cysteine-rich ADAM_CR_2 PF17771.1 KII63089.1 - 0.0018 18.8 1.3 0.0018 18.8 1.3 4.2 1 1 3 4 4 4 2 ADAM cysteine-rich domain OATP PF03137.20 KII63090.1 - 1.7e-32 112.5 11.4 2.1e-32 112.1 11.4 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KII63090.1 - 2.7e-11 43.0 4.2 4.8e-11 42.2 4.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Vut_1 PF02592.15 KII63090.1 - 0.00035 20.9 0.7 0.00035 20.9 0.7 2.2 2 0 0 2 2 2 1 Putative vitamin uptake transporter CrgA PF06781.12 KII63090.1 - 0.012 15.7 5.4 0.013 15.5 0.6 2.9 3 0 0 3 3 3 0 Cell division protein CrgA ISK_Channel PF02060.15 KII63090.1 - 3.7 7.3 5.2 1.8 8.3 0.3 2.5 2 1 1 3 3 3 0 Slow voltage-gated potassium channel OATP PF03137.20 KII63091.1 - 2.5e-11 42.6 0.2 2.8e-11 42.4 0.2 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF3792 PF12670.7 KII63091.1 - 0.011 15.8 0.5 0.012 15.7 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) ECF_trnsprt PF12822.7 KII63091.1 - 0.017 15.2 0.3 0.019 15.1 0.3 1.1 1 0 0 1 1 1 0 ECF transporter, substrate-specific component MFS_1 PF07690.16 KII63091.1 - 0.034 13.1 0.5 0.034 13.1 0.5 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily OATP PF03137.20 KII63092.1 - 3.7e-16 58.5 0.1 4.2e-16 58.4 0.1 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family ENTH PF01417.20 KII63095.1 - 0.0003 20.8 0.0 0.00056 20.0 0.0 1.3 1 0 0 1 1 1 1 ENTH domain OATP PF03137.20 KII63096.1 - 7.9e-30 103.6 20.6 3.3e-29 101.6 20.6 1.8 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KII63096.1 - 1.3e-11 44.0 24.2 1.6e-07 30.6 10.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Ceramidase PF05875.12 KII63096.1 - 0.45 9.9 10.2 0.14 11.6 2.2 2.9 2 1 0 2 2 2 0 Ceramidase Pkinase PF00069.25 KII63097.1 - 1.4e-40 139.4 0.0 1.6e-40 139.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII63097.1 - 1.3e-26 93.5 0.0 1.6e-26 93.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KII63097.1 - 0.0011 18.4 0.0 0.002 17.5 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII63097.1 - 0.0024 17.8 0.0 0.0027 17.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KII63097.1 - 0.003 16.6 0.0 0.011 14.7 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KII63097.1 - 0.0034 17.0 0.0 0.0045 16.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 KII63097.1 - 0.039 13.3 0.0 0.12 11.7 0.0 1.7 1 1 1 2 2 2 0 Kinase-like OATP PF03137.20 KII63098.1 - 2.2e-05 23.0 1.9 2.6e-05 22.7 1.9 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Pox_G7 PF05503.12 KII63098.1 - 0.02 13.8 0.1 0.029 13.3 0.1 1.1 1 0 0 1 1 1 0 Poxvirus G7-like DUF5563 PF17718.1 KII63099.1 - 0.0089 15.6 0.1 0.019 14.6 0.1 1.5 1 1 1 2 2 2 1 Family of unknown function (DUF5563) OATP PF03137.20 KII63102.1 - 4.5e-58 196.9 16.9 6.5e-58 196.3 16.9 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KII63102.1 - 9.3e-16 57.7 4.1 9.3e-16 57.7 4.1 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.15 KII63102.1 - 0.011 15.9 6.9 0.027 14.6 6.9 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KII63102.1 - 0.018 15.1 3.6 0.055 13.5 3.6 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain UPF0370 PF13980.6 KII63102.1 - 0.15 12.1 0.5 0.43 10.6 0.5 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) DUF3437 PF11919.8 KII63103.1 - 0.14 12.1 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) DDE_Tnp_IS1595 PF12762.7 KII63105.1 - 3.4e-13 49.9 0.0 4.6e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain PIG-P PF08510.12 KII63110.1 - 0.0046 16.9 0.5 0.01 15.7 0.5 1.7 1 1 0 1 1 1 1 PIG-P AgrB PF04647.15 KII63110.1 - 0.32 10.3 10.2 0.36 10.1 10.2 1.1 1 0 0 1 1 1 0 Accessory gene regulator B Sortilin-Vps10 PF15902.5 KII63113.1 - 7.1e-09 35.0 4.4 6.1e-07 28.6 1.7 3.0 2 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII63113.1 - 0.00037 20.1 2.5 3.1 8.2 0.0 4.2 4 0 0 4 4 4 2 BNR/Asp-box repeat Ldl_recept_a PF00057.18 KII63113.1 - 0.0028 17.8 17.3 0.0028 17.8 17.3 2.7 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A Serpin PF00079.20 KII63115.1 - 3.7e-45 154.8 2.5 4.3e-45 154.6 2.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII63116.1 - 4.8e-34 118.3 2.8 5.7e-34 118.0 2.8 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-UBR PF02207.20 KII63125.1 - 7.2e-10 38.9 13.4 7.2e-10 38.9 13.4 2.2 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) CcmD PF04995.14 KII63128.1 - 0.0012 18.9 0.0 0.0023 18.0 0.0 1.4 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) PAP2_3 PF14378.6 KII63129.1 - 1.4e-05 24.8 2.8 2.2e-05 24.2 2.8 1.3 1 0 0 1 1 1 1 PAP2 superfamily DUF2556 PF10831.8 KII63129.1 - 0.013 15.4 1.2 0.034 14.1 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2556) Promethin PF16015.5 KII63129.1 - 2.6 8.0 17.5 0.68 9.9 13.1 2.0 1 1 1 2 2 2 0 Promethin HTH_23 PF13384.6 KII63133.1 - 0.022 14.6 0.1 0.065 13.1 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_1 PF01527.20 KII63133.1 - 0.061 13.7 0.0 0.089 13.1 0.0 1.3 1 0 0 1 1 1 0 Transposase ASL_C PF08328.11 KII63133.1 - 0.099 12.7 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal DDE_3 PF13358.6 KII63134.1 - 1.2e-06 28.3 0.0 2.1e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_38 PF13936.6 KII63136.1 - 0.078 12.7 0.2 0.13 12.0 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 KII63136.1 - 0.13 12.1 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain HapK PF11639.8 KII63139.1 - 0.083 13.4 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 REDY-like protein HapK SHS2_Rpb7-N PF03876.17 KII63140.1 - 1.1e-11 44.9 0.1 1.6e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 KII63140.1 - 1.3e-10 41.6 0.4 1.4e-07 31.8 0.1 2.9 2 1 1 3 3 3 2 RNA polymerase III subunit Rpc25 WD40 PF00400.32 KII63141.1 - 6.9e-33 112.2 29.9 4.9e-09 36.7 0.2 8.4 8 1 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII63141.1 - 3.7e-13 49.6 8.2 0.00061 20.0 0.6 5.4 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 KII63141.1 - 7e-05 21.9 2.1 0.13 11.2 0.3 2.6 2 0 0 2 2 2 2 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 KII63141.1 - 0.00014 20.9 0.1 0.099 11.6 0.1 2.9 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KII63141.1 - 0.00015 20.5 2.0 0.019 13.7 0.0 3.2 3 2 0 3 3 3 2 Nucleoporin Nup120/160 TFIIIC_delta PF12657.7 KII63141.1 - 0.00075 19.5 0.9 0.0016 18.4 0.9 1.5 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term WD40_like PF17005.5 KII63141.1 - 0.02 14.3 0.2 0.12 11.7 0.0 2.2 2 1 0 2 2 2 0 WD40-like domain DUF1724 PF08350.10 KII63141.1 - 0.28 11.4 1.8 6 7.1 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1724) Hat1_N PF10394.9 KII63142.1 - 0.044 14.0 0.3 3.4 7.9 0.1 2.2 2 0 0 2 2 2 0 Histone acetyl transferase HAT1 N-terminus PhoLip_ATPase_C PF16212.5 KII63144.1 - 3.2e-22 79.5 12.9 7.8e-22 78.2 12.9 1.6 1 1 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase_3 PF08282.12 KII63144.1 - 0.0045 16.8 0.0 0.0062 16.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase MPS-4 PF17523.2 KII63144.1 - 0.086 13.0 2.8 0.13 12.4 2.8 1.3 1 0 0 1 1 1 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Cation_ATPase PF13246.6 KII63145.1 - 6.9e-10 38.9 0.2 2.8e-08 33.7 0.1 2.3 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KII63145.1 - 5.3e-06 26.9 0.0 1.8e-05 25.1 0.0 1.5 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3052 PF11253.8 KII63145.1 - 0.043 13.7 0.1 0.068 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) DUF3910 PF13049.6 KII63145.1 - 0.06 13.6 0.1 0.14 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3910) PhoLip_ATPase_N PF16209.5 KII63146.1 - 2.2e-10 40.1 1.6 5.4e-10 38.8 1.6 1.7 1 1 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 KII63146.1 - 5e-06 26.2 1.8 1.3e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase PhoLip_ATPase_C PF16212.5 KII63148.1 - 3.3e-25 89.3 11.6 5.4e-25 88.6 11.6 1.3 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 KII63148.1 - 8.1e-09 36.1 0.0 2.3e-08 34.6 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KII63148.1 - 0.00068 19.4 0.0 0.0071 16.1 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KII63148.1 - 0.067 13.3 0.0 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Cation transport ATPase (P-type) DUF3052 PF11253.8 KII63148.1 - 0.093 12.7 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) MLVIN_C PF18697.1 KII63149.1 - 0.068 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain AT_hook PF02178.19 KII63149.1 - 5.9 7.1 8.9 14 6.0 8.9 1.6 1 0 0 1 1 1 0 AT hook motif Ceramidase PF05875.12 KII63150.1 - 3.5e-51 174.1 6.7 4.3e-51 173.9 6.7 1.0 1 0 0 1 1 1 1 Ceramidase SK_channel PF03530.14 KII63150.1 - 0.063 13.3 0.2 0.2 11.6 0.1 2.0 1 1 0 1 1 1 0 Calcium-activated SK potassium channel DUF3792 PF12670.7 KII63150.1 - 2 8.6 10.6 0.4 10.9 3.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3792) EamA PF00892.20 KII63150.1 - 2.5 8.2 12.3 7 6.8 3.4 2.9 1 1 2 3 3 3 0 EamA-like transporter family TehB PF03848.14 KII63151.1 - 0.013 14.9 0.3 0.018 14.5 0.2 1.3 1 1 0 1 1 1 0 Tellurite resistance protein TehB DUF5510 PF17629.2 KII63151.1 - 0.029 14.3 0.1 0.45 10.5 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5510) zf-MYND PF01753.18 KII63152.1 - 1.7e-06 28.0 19.9 2.7e-06 27.4 19.9 1.3 1 0 0 1 1 1 1 MYND finger GlutR_dimer PF00745.20 KII63152.1 - 0.091 13.2 0.2 0.19 12.2 0.2 1.5 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain LPP PF04728.13 KII63152.1 - 0.71 10.3 2.8 2.8 8.4 2.8 2.0 1 1 0 1 1 1 0 Lipoprotein leucine-zipper LRR_8 PF13855.6 KII63153.1 - 4.7e-28 96.7 19.6 7.2e-12 44.9 4.9 2.8 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KII63153.1 - 9.9e-18 64.0 25.9 5.7e-07 29.7 3.9 4.1 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KII63153.1 - 4.5e-08 32.6 21.4 0.58 10.9 0.9 6.3 5 1 1 6 6 6 4 Leucine Rich Repeat LRR_9 PF14580.6 KII63153.1 - 6.8e-05 22.4 10.1 0.0066 16.0 2.7 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 KII63153.1 - 0.0011 18.8 20.7 1.2 9.4 0.4 6.0 6 0 0 6 6 6 3 Leucine Rich repeat LRR_5 PF13306.6 KII63153.1 - 0.0021 18.0 5.9 0.014 15.4 2.9 2.0 1 1 1 2 2 2 1 BspA type Leucine rich repeat region (6 copies) SNAP PF14938.6 KII63154.1 - 1.2e-06 28.2 1.0 1.2e-06 28.2 1.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 KII63154.1 - 0.00096 18.9 2.1 0.64 9.9 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KII63154.1 - 0.0012 18.7 0.8 0.061 13.4 0.7 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KII63154.1 - 0.0012 18.7 1.7 2.2 8.6 0.1 3.6 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KII63154.1 - 0.0014 18.9 0.2 0.12 12.6 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII63154.1 - 0.0061 16.7 7.2 0.018 15.3 0.3 3.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KII63154.1 - 0.11 13.1 0.2 0.87 10.3 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 KII63155.1 - 0.00073 19.1 0.8 0.0008 18.9 0.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DIX PF00778.17 KII63157.1 - 4.4e-09 36.0 0.0 8.6e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 DIX domain DUF3377 PF11857.8 KII63160.1 - 0.14 12.1 0.7 0.32 11.0 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) JTB PF05439.12 KII63160.1 - 0.21 11.7 4.1 0.34 11.0 4.1 1.4 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) HSP70 PF00012.20 KII63161.1 - 4.7e-225 748.3 3.7 5.3e-225 748.2 3.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KII63161.1 - 7.3e-20 71.0 1.5 5.4e-17 61.6 0.5 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 KII63161.1 - 0.0013 19.1 1.8 0.73 10.3 0.1 3.2 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.16 KII63161.1 - 0.0093 15.7 0.0 0.022 14.5 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Prominin PF05478.11 KII63161.1 - 0.044 11.7 2.2 0.084 10.8 0.0 1.9 2 0 0 2 2 2 0 Prominin UCH PF00443.29 KII63162.1 - 1.8e-14 53.8 0.0 2e-14 53.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KII63162.1 - 0.00095 18.8 0.0 0.0011 18.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase LPD37 PF18853.1 KII63162.1 - 0.055 13.0 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 37 NDK PF00334.19 KII63164.1 - 8.3e-52 174.8 0.0 9.5e-52 174.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Na_H_Exchanger PF00999.21 KII63167.1 - 0.13 11.1 0.1 0.17 10.7 0.1 1.1 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family TPR_1 PF00515.28 KII63169.1 - 1.1e-14 53.5 9.4 1.7e-05 24.4 0.4 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KII63169.1 - 2.3e-12 46.0 6.8 0.0006 19.7 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KII63169.1 - 3.4e-09 36.2 1.0 0.016 14.9 0.0 3.3 2 1 1 3 3 3 3 TPR repeat TPR_12 PF13424.6 KII63169.1 - 1.4e-07 31.7 2.4 1.3e-05 25.4 0.6 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII63169.1 - 3e-06 27.0 1.6 0.092 13.0 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KII63169.1 - 0.0024 18.1 1.3 0.0068 16.6 1.2 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KII63169.1 - 0.0043 17.0 1.0 1.6 8.9 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KII63169.1 - 0.037 14.5 1.3 0.069 13.7 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat ArsR PF09824.9 KII63169.1 - 0.041 13.5 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 ArsR transcriptional regulator TPR_14 PF13428.6 KII63169.1 - 0.056 14.3 0.0 8.5 7.5 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 KII63169.1 - 0.42 11.1 4.9 4.5 7.9 0.1 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat Cystatin PF00031.21 KII63170.1 - 0.00036 20.7 0.1 0.00043 20.5 0.1 1.2 1 0 0 1 1 1 1 Cystatin domain GxDLY PF14607.6 KII63170.1 - 0.095 12.5 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 N-terminus of Esterase_SGNH_hydro-type DDE_Tnp_IS1595 PF12762.7 KII63171.1 - 7.5e-08 32.5 0.0 1.6e-07 31.4 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain Prenyltransf PF01255.19 KII63172.1 - 4.6e-38 131.0 0.1 5.2e-38 130.8 0.1 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PALP PF00291.25 KII63176.1 - 1.8e-44 152.4 0.0 1.9e-44 152.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Methyltransf_12 PF08242.12 KII63176.1 - 0.07 13.9 0.0 0.22 12.3 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase domain CM_2 PF01817.21 KII63177.1 - 0.058 13.7 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Chorismate mutase type II CBS PF00571.28 KII63177.1 - 0.14 12.6 0.0 0.59 10.6 0.0 1.9 2 0 0 2 2 2 0 CBS domain SPRY PF00622.28 KII63178.1 - 0.00031 20.8 0.1 0.00051 20.1 0.1 1.4 1 0 0 1 1 1 1 SPRY domain BLOC1_2 PF10046.9 KII63179.1 - 0.00057 20.1 0.4 0.00086 19.6 0.4 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 SIKE PF05769.11 KII63179.1 - 0.011 15.7 0.0 0.012 15.6 0.0 1.1 1 0 0 1 1 1 0 SIKE family Lzipper-MIP1 PF14389.6 KII63179.1 - 0.016 15.5 0.6 0.027 14.7 0.6 1.5 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 DDE_3 PF13358.6 KII63180.1 - 1.2e-07 31.6 0.0 1.4e-07 31.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease P4Ha_N PF08336.11 KII63181.1 - 6.4e-12 45.7 0.7 3.1e-11 43.4 0.0 2.3 3 0 0 3 3 3 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_2 PF07719.17 KII63181.1 - 0.0057 16.7 0.0 0.029 14.5 0.0 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KII63181.1 - 0.032 14.1 0.0 0.22 11.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4576 PF15144.6 KII63181.1 - 0.13 12.1 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) Ribosomal_L10 PF00466.20 KII63182.1 - 0.057 13.6 0.0 0.079 13.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L10 DUF4923 PF16270.5 KII63183.1 - 0.068 13.0 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Lipocalin-like domain (DUF4923) FYVE PF01363.21 KII63186.1 - 4.3e-13 49.2 5.4 8.1e-13 48.3 5.4 1.5 1 0 0 1 1 1 1 FYVE zinc finger DUF4618 PF15397.6 KII63186.1 - 0.0044 16.5 19.2 0.0044 16.5 19.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4618) CO_deh_flav_C PF03450.17 KII63186.1 - 0.034 14.3 0.0 1.6 9.0 0.0 2.4 1 1 1 2 2 2 0 CO dehydrogenase flavoprotein C-terminal domain DUF2935 PF11155.8 KII63186.1 - 0.038 14.3 0.3 0.038 14.3 0.3 2.2 2 2 1 3 3 3 0 Domain of unknown function (DUF2935) DUF641 PF04859.12 KII63186.1 - 0.045 14.1 15.8 0.05 13.9 5.9 3.3 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) SSXT PF05030.12 KII63186.1 - 0.068 12.8 4.6 0.23 11.1 4.6 1.9 1 0 0 1 1 1 0 SSXT protein (N-terminal region) CAMSAP_CC1 PF17095.5 KII63186.1 - 0.12 12.2 3.4 0.18 11.7 0.0 2.7 3 0 0 3 3 3 0 Spectrin-binding region of Ca2+-Calmodulin PKcGMP_CC PF16808.5 KII63186.1 - 0.45 10.4 6.8 3 7.8 0.7 2.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase OmpH PF03938.14 KII63186.1 - 0.52 10.6 15.8 5 7.5 4.4 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) TMF_DNA_bd PF12329.8 KII63186.1 - 0.52 10.3 27.2 0.041 13.9 5.7 3.4 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Sec8_exocyst PF04048.14 KII63186.1 - 2.5 8.0 15.2 0.14 12.0 5.0 3.4 2 2 1 4 4 4 0 Sec8 exocyst complex component specific domain CENP-F_leu_zip PF10473.9 KII63186.1 - 2.5 8.1 21.3 0.96 9.5 12.0 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Remorin_C PF03763.13 KII63186.1 - 4.1 7.3 10.3 0.5 10.3 4.3 2.4 1 1 1 2 2 2 0 Remorin, C-terminal region Fib_alpha PF08702.10 KII63186.1 - 8.2 6.6 26.2 0.47 10.6 10.3 3.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DDE_Tnp_IS1595 PF12762.7 KII63189.1 - 0.0003 20.8 0.1 0.022 14.8 0.0 2.4 2 0 0 2 2 2 1 ISXO2-like transposase domain AP3D1 PF06375.11 KII63189.1 - 0.014 15.6 5.6 0.02 15.1 5.6 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Pox_Ag35 PF03286.14 KII63189.1 - 0.02 14.7 7.4 0.029 14.2 7.4 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.6 KII63189.1 - 0.022 14.4 2.9 0.039 13.6 2.9 1.4 1 0 0 1 1 1 0 FAM176 family Nop53 PF07767.11 KII63189.1 - 0.039 13.3 10.2 0.052 12.9 10.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 KII63189.1 - 0.088 11.1 0.7 0.096 11.0 0.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SWIRM-assoc_2 PF16496.5 KII63189.1 - 0.14 11.0 5.0 0.21 10.4 5.0 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Presenilin PF01080.17 KII63189.1 - 0.28 9.9 0.4 0.35 9.6 0.4 1.1 1 0 0 1 1 1 0 Presenilin Cas_Csy4 PF09618.10 KII63189.1 - 0.33 11.1 1.9 10 6.2 2.6 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) Eapp_C PF10238.9 KII63189.1 - 0.42 10.7 9.0 0.74 9.9 9.0 1.5 1 1 0 1 1 1 0 E2F-associated phosphoprotein NARP1 PF12569.8 KII63189.1 - 1.7 7.5 9.0 2.5 6.9 9.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Coilin_N PF15862.5 KII63189.1 - 3.1 7.6 9.8 5.5 6.8 9.8 1.3 1 0 0 1 1 1 0 Coilin N-terminus Ribosomal_60s PF00428.19 KII63189.1 - 5.7 7.6 9.2 9.4 6.9 9.2 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein MAP17 PF15807.5 KII63189.1 - 6.6 7.0 6.7 12 6.2 6.7 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 RT_RNaseH_2 PF17919.1 KII63191.1 - 7.2e-37 125.4 0.1 1.6e-36 124.3 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63191.1 - 3.3e-36 123.7 0.0 9.3e-36 122.3 0.0 1.8 2 0 0 2 2 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII63191.1 - 1.5e-26 93.3 0.0 2.6e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII63191.1 - 2.5e-24 85.8 0.0 7.5e-24 84.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63191.1 - 5.4e-17 61.7 1.3 1.6e-16 60.2 1.3 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII63191.1 - 1e-07 32.1 0.0 3.7e-07 30.2 0.0 2.1 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC PF00098.23 KII63191.1 - 3e-05 23.9 11.3 0.016 15.2 2.1 2.7 2 0 0 2 2 2 2 Zinc knuckle gag-asp_proteas PF13975.6 KII63191.1 - 3.1e-05 24.5 0.0 6.8e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII63191.1 - 0.024 14.9 0.0 0.086 13.2 0.0 2.0 1 0 0 1 1 1 0 Retroviral aspartyl protease MLVIN_C PF18697.1 KII63191.1 - 0.024 14.7 0.0 0.057 13.5 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain zf-CCHC_4 PF14392.6 KII63191.1 - 0.034 13.9 7.6 1.6 8.5 0.6 3.1 1 1 1 2 2 2 0 Zinc knuckle rve_3 PF13683.6 KII63191.1 - 0.036 13.9 0.0 0.094 12.5 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Asp_protease_2 PF13650.6 KII63191.1 - 0.044 14.4 0.1 0.09 13.4 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease Spuma_A9PTase PF03539.14 KII63191.1 - 0.05 13.8 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP_2 PF08284.11 KII63191.1 - 0.054 13.3 0.2 0.12 12.1 0.2 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_6 PF15288.6 KII63191.1 - 0.11 12.4 11.8 0.72 9.7 0.8 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-UBR PF02207.20 KII63193.1 - 1.3e-09 38.1 16.6 2.4e-09 37.2 16.6 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) HOCHOB PF17943.1 KII63193.1 - 0.011 16.4 2.2 0.023 15.4 2.2 1.7 1 0 0 1 1 1 0 Homeobox-cysteine loop-homeobox DDE_3 PF13358.6 KII63194.1 - 0.0013 18.5 0.0 0.002 17.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Sigma_reg_C PF13791.6 KII63194.1 - 0.025 14.8 0.1 0.029 14.6 0.1 1.1 1 0 0 1 1 1 0 Sigma factor regulator C-terminal HTH_33 PF13592.6 KII63194.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix ParA PF10609.9 KII63195.1 - 1.9e-69 233.9 0.0 2.4e-69 233.5 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KII63195.1 - 6.7e-08 32.7 0.0 1.1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 KII63195.1 - 1e-07 31.4 0.3 0.002 17.4 0.0 2.4 2 0 0 2 2 2 2 Anion-transporting ATPase AAA_31 PF13614.6 KII63195.1 - 2.4e-07 30.9 0.4 5.2e-06 26.5 0.4 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 KII63195.1 - 4.8e-06 26.1 0.0 6.4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 ATPase MipZ Zeta_toxin PF06414.12 KII63195.1 - 0.0031 16.8 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.22 KII63195.1 - 0.006 15.8 1.3 0.0073 15.5 0.2 1.6 2 0 0 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 KII63195.1 - 0.022 14.7 0.4 0.14 12.0 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_26 PF13500.6 KII63195.1 - 0.044 13.6 1.0 0.54 10.0 1.1 2.1 1 1 0 1 1 1 0 AAA domain CLP1_P PF16575.5 KII63195.1 - 0.11 12.3 0.4 2.4 7.9 0.0 2.1 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ABC_tran PF00005.27 KII63195.1 - 0.12 12.9 0.1 0.19 12.2 0.1 1.4 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 KII63195.1 - 0.13 12.7 0.1 0.43 11.0 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 KII63195.1 - 0.15 12.6 0.0 0.31 11.6 0.0 1.6 2 0 0 2 2 1 0 AAA domain DUF1241 PF06840.11 KII63196.1 - 4e-10 39.5 0.1 5.9e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Syntaxin_2 PF14523.6 KII63196.1 - 0.01 16.2 0.7 0.019 15.3 0.1 1.8 3 0 0 3 3 3 0 Syntaxin-like protein PBP_GOBP PF01395.22 KII63196.1 - 0.032 14.4 0.0 0.049 13.8 0.0 1.3 1 0 0 1 1 1 0 PBP/GOBP family Pyrid_ox_like PF16242.5 KII63196.1 - 0.046 13.3 0.1 0.076 12.6 0.1 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like HTH_32 PF13565.6 KII63197.1 - 8.5e-05 23.1 0.8 0.0001 22.8 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 KII63197.1 - 0.005 16.4 0.0 0.008 15.8 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.18 KII63197.1 - 0.019 14.9 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 'Paired box' domain CENP-B_dimeris PF09026.10 KII63198.1 - 0.0039 17.6 0.1 0.0052 17.1 0.1 1.3 1 0 0 1 1 1 1 Centromere protein B dimerisation domain SUI1 PF01253.22 KII63199.1 - 6.1e-18 65.1 0.1 7.7e-18 64.8 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 KII63199.1 - 0.015 15.6 0.2 0.021 15.1 0.2 1.5 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) Dak2 PF02734.17 KII63200.1 - 0.058 13.3 0.3 0.15 11.9 0.3 1.7 1 0 0 1 1 1 0 DAK2 domain NIF PF03031.18 KII63201.1 - 2.4e-46 157.4 0.3 3.8e-46 156.7 0.3 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 KII63201.1 - 0.13 12.6 0.1 0.92 9.9 0.0 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Rap_GAP PF02145.15 KII63202.1 - 5.8e-61 205.3 0.7 5.8e-61 205.3 0.7 1.9 2 0 0 2 2 2 1 Rap/ran-GAP PDZ_6 PF17820.1 KII63202.1 - 0.034 14.0 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 PDZ domain DNA_pol_P_Exo PF18049.1 KII63202.1 - 0.56 9.6 2.8 2.1 7.7 0.9 2.4 2 0 0 2 2 2 0 DNA polymerase nu pseudo-exo PIN_2 PF10130.9 KII63205.1 - 0.16 12.2 0.2 0.34 11.1 0.2 1.4 1 1 0 1 1 1 0 PIN domain G-alpha PF00503.20 KII63207.1 - 5.6e-102 341.5 7.5 6.8e-102 341.2 7.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KII63207.1 - 1.3e-14 54.0 0.2 5.2e-11 42.3 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII63207.1 - 0.00087 18.7 5.7 0.033 13.6 1.7 2.6 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KII63207.1 - 0.0058 16.7 0.0 0.17 12.0 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DAP3 PF10236.9 KII63207.1 - 0.056 12.6 0.2 0.12 11.6 0.2 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Roc PF08477.13 KII63207.1 - 0.061 13.5 0.1 4.7 7.5 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_11 PF13086.6 KII63208.1 - 7e-46 157.1 0.2 1e-45 156.6 0.2 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KII63208.1 - 9.1e-13 48.4 0.0 2.3e-09 37.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KII63208.1 - 6.6e-11 42.7 0.1 5.7e-10 39.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 KII63208.1 - 8.5e-09 35.3 0.0 2.6e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 KII63208.1 - 9.7e-07 28.6 1.6 0.00034 20.2 0.0 2.7 3 0 0 3 3 3 2 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 KII63208.1 - 5.9e-05 22.5 0.1 0.00011 21.6 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KII63208.1 - 0.00033 20.7 0.0 0.00092 19.3 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 KII63208.1 - 0.00068 19.5 0.1 0.0015 18.4 0.1 1.6 1 0 0 1 1 1 1 Helicase DEAD PF00270.29 KII63208.1 - 0.0014 18.4 0.1 0.0032 17.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase PIF1 PF05970.14 KII63208.1 - 0.002 17.4 0.1 0.18 11.0 0.1 2.2 2 0 0 2 2 2 1 PIF1-like helicase SMC_N PF02463.19 KII63208.1 - 0.0031 17.0 0.5 0.0062 16.0 0.5 1.4 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KII63208.1 - 0.0031 18.1 1.7 0.0052 17.3 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KII63208.1 - 0.004 17.6 0.3 0.0088 16.5 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KII63208.1 - 0.022 13.8 0.0 0.04 13.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_10 PF12846.7 KII63208.1 - 0.029 13.3 0.1 0.052 12.5 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain PhoH PF02562.16 KII63208.1 - 0.059 12.8 0.0 0.16 11.4 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_26 PF13500.6 KII63208.1 - 0.065 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KII63208.1 - 0.067 13.6 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ATPase PF06745.13 KII63208.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 KaiC DUF1140 PF06600.11 KII63208.1 - 2.1 8.9 4.7 2.8 8.4 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1140) AAA_12 PF13087.6 KII63209.1 - 1.4e-33 116.2 0.0 1.6e-33 116.0 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KII63209.1 - 0.0086 15.9 0.0 0.027 14.3 0.0 1.8 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain DDE_3 PF13358.6 KII63212.1 - 1.9e-23 82.9 0.0 3.4e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII63212.1 - 0.00012 21.8 0.3 0.0048 16.6 0.1 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 KII63212.1 - 0.0036 17.4 0.1 0.0082 16.2 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII63212.1 - 0.0061 16.8 0.2 0.014 15.6 0.2 1.6 1 0 0 1 1 1 1 Transposase rve PF00665.26 KII63212.1 - 0.0069 16.6 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_ISAZ013 PF07592.11 KII63212.1 - 0.0089 15.0 0.3 0.69 8.8 0.0 2.2 2 0 0 2 2 2 1 Rhodopirellula transposase DDE domain HTH_29 PF13551.6 KII63212.1 - 0.015 15.3 0.2 0.12 12.5 0.1 2.3 2 0 0 2 2 2 0 Winged helix-turn helix HTH_5 PF01022.20 KII63212.1 - 0.016 15.1 0.1 0.061 13.2 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family YflT PF11181.8 KII63212.1 - 0.021 15.3 0.1 0.049 14.1 0.1 1.6 1 0 0 1 1 1 0 Heat induced stress protein YflT HTH_Tnp_1 PF01527.20 KII63212.1 - 0.1 12.9 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Transposase Trp_repressor PF01371.19 KII63212.1 - 0.3 11.2 4.0 0.12 12.5 1.1 1.8 2 0 0 2 2 2 0 Trp repressor protein Peptidase_M18 PF02127.15 KII63213.1 - 1.7e-135 452.1 0.2 2.1e-91 306.9 0.1 2.0 1 1 1 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 KII63213.1 - 4.2e-05 22.7 0.0 0.00072 18.7 0.0 2.1 1 1 1 2 2 2 1 M42 glutamyl aminopeptidase HTH_26 PF13443.6 KII63213.1 - 0.057 13.9 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain WD40 PF00400.32 KII63214.1 - 1.1e-39 133.7 14.0 7.5e-12 45.6 0.2 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII63214.1 - 6.5e-14 52.0 0.0 1e-05 25.7 0.0 4.6 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KII63214.1 - 2e-06 26.8 0.3 0.0056 15.4 0.0 3.2 3 0 0 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 KII63214.1 - 0.00012 21.6 0.0 0.15 11.4 0.0 3.3 3 1 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 KII63214.1 - 0.0026 16.8 0.5 2.1 7.3 0.0 3.7 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2833 PF11090.8 KII63214.1 - 0.032 14.6 0.1 0.1 13.0 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2833) RAB3GAP2_N PF14655.6 KII63214.1 - 0.096 11.9 0.0 0.93 8.7 0.0 2.4 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TFIID_NTD2 PF04494.15 KII63215.1 - 1.3e-09 38.3 1.1 1.9e-09 37.9 1.1 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain Lyase_8 PF02278.18 KII63215.1 - 0.087 12.3 0.2 0.099 12.1 0.2 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, super-sandwich domain Tubulin PF00091.25 KII63216.1 - 4.7e-67 226.0 0.0 7.3e-67 225.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KII63216.1 - 4.4e-45 152.9 0.6 6.9e-45 152.3 0.6 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KII63216.1 - 6.2e-05 23.3 0.1 0.00038 20.7 0.1 2.2 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Hrs_helical PF12210.8 KII63216.1 - 0.22 12.1 0.5 4.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate RED_C PF07807.11 KII63217.1 - 6.8e-10 39.4 3.0 1.4e-09 38.4 3.0 1.5 1 0 0 1 1 1 1 RED-like protein C-terminal region PTPLA PF04387.14 KII63218.1 - 2.1e-19 69.8 6.8 2.1e-19 69.8 6.8 1.4 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA DDE_3 PF13358.6 KII63219.1 - 0.00068 19.4 0.0 0.0015 18.3 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease LMBR1 PF04791.16 KII63222.1 - 5.6e-87 292.8 36.8 6.8e-87 292.5 36.8 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Holin_BhlA PF10960.8 KII63222.1 - 0.7 9.9 4.1 17 5.4 0.0 2.9 3 0 0 3 3 3 0 BhlA holin family Sulfatase PF00884.23 KII63223.1 - 5.9e-11 42.3 0.0 6.8e-10 38.8 0.0 2.3 2 0 0 2 2 2 1 Sulfatase Amnionless PF14828.6 KII63223.1 - 0.037 12.9 0.1 0.087 11.6 0.1 1.6 1 0 0 1 1 1 0 Amnionless Sulfatase PF00884.23 KII63224.1 - 3.6e-29 102.1 0.5 4.3e-29 101.9 0.5 1.0 1 0 0 1 1 1 1 Sulfatase RRM_1 PF00076.22 KII63225.1 - 8.1e-38 128.1 0.0 2e-22 78.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII63225.1 - 0.00024 21.2 0.0 0.011 15.8 0.0 2.6 2 1 0 2 2 2 1 RNA recognition motif RRM_3 PF08777.11 KII63225.1 - 0.0011 19.0 0.0 0.0037 17.3 0.0 1.9 2 0 0 2 2 2 1 RNA binding motif PHM7_cyt PF14703.6 KII63225.1 - 0.0031 17.8 0.1 2.1 8.6 0.1 3.0 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.5 KII63225.1 - 0.0085 15.9 0.0 0.078 12.8 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif Apt1 PF10351.9 KII63225.1 - 0.31 9.8 9.0 0.38 9.6 9.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain PRP38_assoc PF12871.7 KII63225.1 - 1.4 9.5 58.5 2.7 8.7 58.5 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF2332 PF10094.9 KII63226.1 - 0.063 12.7 0.0 0.082 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2332) Maf1 PF09174.10 KII63227.1 - 4.3e-14 53.1 1.8 6.7e-13 49.2 1.8 2.0 1 1 0 1 1 1 1 Maf1 regulator Sas10_Utp3 PF04000.15 KII63228.1 - 1.5e-10 41.5 0.1 2.6e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Herpes_V23 PF01802.17 KII63228.1 - 0.048 13.1 0.1 0.061 12.7 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein OAS1_C PF10421.9 KII63228.1 - 0.084 12.4 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Peptidase_M41 PF01434.18 KII63229.1 - 4.9e-55 186.3 0.1 7.6e-55 185.7 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KII63229.1 - 4e-22 79.1 0.0 1.3e-21 77.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KII63229.1 - 1e-11 44.5 0.0 1.9e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain RPN7 PF10602.9 KII63229.1 - 0.066 12.9 0.7 0.11 12.2 0.7 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 DDE_3 PF13358.6 KII63231.1 - 1.8e-08 34.2 0.1 2.5e-08 33.8 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease TPR_8 PF13181.6 KII63232.1 - 0.0038 17.3 1.1 2.6 8.5 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII63232.1 - 0.047 13.8 1.4 5.1 7.5 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 KII63232.1 - 0.13 12.6 0.2 2.4 8.5 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII63232.1 - 0.25 11.3 2.7 2.1 8.3 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Ins134_P3_kin PF05770.11 KII63233.1 - 3.6e-27 95.2 0.2 6.3e-27 94.4 0.2 1.3 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain ATPgrasp_YheCD PF14398.6 KII63233.1 - 0.0043 16.3 0.1 0.011 15.0 0.0 1.8 2 0 0 2 2 2 1 YheC/D like ATP-grasp DUF433 PF04255.14 KII63234.1 - 0.068 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF433) AhpC-TSA_2 PF13911.6 KII63235.1 - 2.2e-16 60.0 0.0 2.6e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme ThiF PF00899.21 KII63236.1 - 5e-67 225.8 0.1 7e-67 225.3 0.1 1.2 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 KII63236.1 - 6e-11 42.8 0.7 5.5e-06 26.5 0.2 2.3 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 KII63236.1 - 1.9e-06 28.4 0.1 2.1e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain NAD_binding_7 PF13241.6 KII63236.1 - 5.6e-06 26.7 0.0 1.3e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 KII63236.1 - 0.0002 21.6 0.1 0.0014 18.8 0.1 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Pyr_redox PF00070.27 KII63236.1 - 0.05 14.2 0.1 0.12 13.0 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KII63236.1 - 0.075 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 KII63236.1 - 0.14 12.2 0.0 0.74 9.9 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 KII63236.1 - 0.29 10.7 0.2 0.47 10.0 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase DDE_3 PF13358.6 KII63238.1 - 1.1e-16 60.9 0.1 3e-16 59.5 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII63238.1 - 0.033 14.4 0.3 0.07 13.4 0.0 1.8 2 0 0 2 2 2 0 Transposase DUF948 PF06103.11 KII63241.1 - 0.32 11.3 6.1 0.097 12.9 3.3 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TFIIA PF03153.13 KII63241.1 - 7.9 6.4 21.2 9.3 6.1 21.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RT_RNaseH_2 PF17919.1 KII63243.1 - 1.6e-39 134.0 0.0 4.1e-39 132.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63243.1 - 7.2e-36 122.7 0.1 2.3e-35 121.1 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII63243.1 - 4.1e-31 108.2 0.5 1e-30 106.9 0.5 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII63243.1 - 8.4e-18 64.7 0.0 1.7e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63243.1 - 1.1e-16 60.6 0.4 3e-16 59.3 0.4 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII63243.1 - 5.7e-06 26.8 0.0 3.3e-05 24.4 0.0 2.3 3 0 0 3 3 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII63243.1 - 3.7e-05 23.6 3.9 0.00012 22.0 3.9 1.9 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 KII63243.1 - 0.00036 21.1 0.1 0.0018 18.9 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-H2C2 PF09337.10 KII63243.1 - 0.0006 20.0 0.4 0.002 18.3 0.4 2.0 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII63243.1 - 0.01 15.6 0.1 0.11 12.4 0.0 2.9 2 0 0 2 2 2 0 Integrase core domain zf-CCHC_4 PF14392.6 KII63243.1 - 0.014 15.1 1.3 0.059 13.1 1.3 2.1 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII63243.1 - 0.02 15.0 0.0 0.052 13.7 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP PF00077.20 KII63243.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease PAP2_C PF14360.6 KII63244.1 - 5.2e-08 33.3 10.5 5.2e-08 33.3 10.5 2.8 2 1 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.21 KII63244.1 - 0.0053 16.5 5.9 0.44 10.3 0.3 2.4 2 1 0 2 2 2 2 PAP2 superfamily RecO_N_2 PF13114.6 KII63244.1 - 0.18 11.5 1.1 23 4.8 0.0 3.2 4 0 0 4 4 4 0 RecO N terminal Rho_GDI PF02115.17 KII63245.1 - 4.9e-24 85.2 0.3 6.2e-24 84.8 0.3 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos_2 PF12850.7 KII63246.1 - 1.1e-16 61.5 0.0 1.5e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 KII63246.1 - 0.01 16.3 0.0 3.3 8.2 0.0 2.3 1 1 1 2 2 2 0 Calcineurin-like phosphoesterase DDE_1 PF03184.19 KII63248.1 - 1e-05 25.2 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Exo_endo_phos_2 PF14529.6 KII63249.1 - 0.066 13.1 0.1 0.3 10.9 0.0 2.0 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 KII63249.1 - 0.071 12.6 0.0 0.21 11.1 0.0 1.8 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Aminotran_3 PF00202.21 KII63250.1 - 2.8e-93 312.8 0.0 3.2e-93 312.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Annexin PF00191.20 KII63251.1 - 5.2e-06 26.4 0.2 7e-06 26.0 0.2 1.2 1 0 0 1 1 1 1 Annexin Herpes_UL42 PF02282.16 KII63251.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.4 1 1 0 1 1 1 0 DNA polymerase processivity factor (UL42) Serpin PF00079.20 KII63252.1 - 3.8e-44 151.5 3.2 5e-44 151.1 3.2 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4250 PF14056.6 KII63252.1 - 0.051 13.5 0.3 0.24 11.4 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) RT_RNaseH_2 PF17919.1 KII63254.1 - 1.8e-09 37.5 0.0 4.4e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63254.1 - 1.1e-08 35.3 0.0 2.6e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DNA_pol_viral_C PF00336.18 KII63254.1 - 0.08 12.3 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RRM_1 PF00076.22 KII63255.1 - 8.7e-27 92.7 1.1 4.1e-21 74.6 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KII63255.1 - 0.051 13.4 0.0 0.44 10.4 0.0 2.6 2 1 0 2 2 2 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KII63255.1 - 0.099 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF4320 PF14208.6 KII63256.1 - 0.12 12.5 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) Ribosomal_L34e PF01199.18 KII63257.1 - 4.2e-44 148.8 5.0 4.9e-44 148.6 5.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L34e His_Me_b4a2 PF18275.1 KII63257.1 - 0.03 14.4 0.1 0.064 13.3 0.1 1.6 1 0 0 1 1 1 0 His-Me finger endonuclease beta4-alpha2 domain Dus PF01207.17 KII63258.1 - 8.4e-50 169.6 0.0 1e-49 169.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Ribonuclease_3 PF00636.26 KII63260.1 - 1.2e-33 115.9 0.0 1.9e-21 76.7 0.0 3.3 4 0 0 4 4 4 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 KII63260.1 - 1.9e-18 66.9 2.2 4.4e-08 33.3 0.3 3.9 4 0 0 4 4 4 2 Ribonuclease-III-like Dicer_dimer PF03368.14 KII63260.1 - 3.8e-16 59.0 0.0 9.4e-16 57.8 0.0 1.7 1 0 0 1 1 1 1 Dicer dimerisation domain Helicase_C PF00271.31 KII63260.1 - 2.4e-12 47.2 1.0 8.9e-12 45.3 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain dsrm PF00035.26 KII63260.1 - 4.8e-12 46.4 1.1 0.00028 21.5 0.0 3.8 3 0 0 3 3 3 3 Double-stranded RNA binding motif DEAD PF00270.29 KII63260.1 - 7.3e-11 42.1 0.0 1.6e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KII63260.1 - 1.3e-09 38.3 0.0 5.1e-09 36.4 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PAZ PF02170.22 KII63260.1 - 0.011 15.6 0.0 0.045 13.6 0.0 2.2 1 0 0 1 1 1 0 PAZ domain PBP_GOBP PF01395.22 KII63260.1 - 0.56 10.4 6.1 0.41 10.8 3.0 2.5 2 0 0 2 2 2 0 PBP/GOBP family DEAD PF00270.29 KII63262.1 - 1.8e-47 161.3 0.2 9.4e-47 159.0 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII63262.1 - 3.6e-24 85.2 1.0 5.9e-23 81.3 0.1 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII63262.1 - 8.5e-08 32.4 0.0 2.7e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 KII63262.1 - 0.00064 19.7 0.1 0.88 9.5 0.0 2.7 2 0 0 2 2 2 2 Flavivirus DEAD domain AAA_22 PF13401.6 KII63262.1 - 0.0014 18.9 0.0 0.0035 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain ERCC3_RAD25_C PF16203.5 KII63262.1 - 0.0027 17.0 0.1 0.007 15.6 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.6 KII63262.1 - 0.02 15.3 0.0 0.037 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 KII63262.1 - 0.032 13.8 0.1 0.069 12.7 0.1 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain UQ_con PF00179.26 KII63263.1 - 2.1e-42 144.1 0.1 2.4e-42 143.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KII63263.1 - 0.0012 18.6 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B rve PF00665.26 KII63264.1 - 1.3e-22 80.2 0.0 2.8e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63264.1 - 7.1e-13 48.5 0.8 2.1e-12 47.0 0.8 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII63264.1 - 0.0042 16.8 0.1 0.013 15.2 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Myosin_tail_1 PF01576.19 KII63265.1 - 7.5e-121 404.9 143.6 3.4e-111 372.9 125.5 2.0 1 1 1 2 2 2 2 Myosin tail CENP-F_leu_zip PF10473.9 KII63265.1 - 0.00086 19.3 151.6 0.093 12.7 25.5 6.4 1 1 6 7 7 7 7 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 KII63265.1 - 0.0011 19.5 23.7 0.0011 19.5 23.7 7.9 1 1 7 8 8 8 1 Apg6 coiled-coil region GAS PF13851.6 KII63265.1 - 0.0016 17.8 40.5 0.0016 17.8 40.5 5.9 1 1 4 5 5 5 2 Growth-arrest specific micro-tubule binding Sec34 PF04136.15 KII63265.1 - 0.013 15.4 3.4 0.013 15.4 3.4 8.1 1 1 6 8 8 8 0 Sec34-like family PPE PF00823.19 KII63265.1 - 0.36 10.9 4.9 0.22 11.6 1.3 2.6 2 0 0 2 2 2 0 PPE family Spc7 PF08317.11 KII63265.1 - 0.44 9.4 142.3 0.06 12.2 23.9 5.6 1 1 5 6 6 6 0 Spc7 kinetochore protein AAA_13 PF13166.6 KII63265.1 - 0.92 8.1 112.7 0.032 12.9 36.1 3.5 1 1 2 3 3 3 0 AAA domain Filament PF00038.21 KII63265.1 - 1 8.9 122.9 0.17 11.5 17.2 4.8 1 1 2 4 4 4 0 Intermediate filament protein Tropomyosin PF00261.20 KII63265.1 - 3.6 6.9 142.7 0.39 10.1 19.2 5.1 1 1 4 5 5 5 0 Tropomyosin CALCOCO1 PF07888.11 KII63265.1 - 4 6.2 136.4 0.051 12.4 47.4 4.4 1 1 3 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like Myosin_head PF00063.21 KII63266.1 - 7.5e-280 929.9 11.7 7.5e-280 929.9 11.7 1.7 2 0 0 2 2 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 KII63266.1 - 6.6e-37 126.9 49.8 8.8e-37 126.5 49.8 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 KII63266.1 - 2.6e-12 46.4 0.0 5.8e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_7 PF12775.7 KII63266.1 - 8.5e-05 22.1 0.1 0.00022 20.8 0.1 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region HAP1_N PF04849.13 KII63266.1 - 0.0011 18.3 13.5 0.0011 18.3 13.5 2.7 1 1 1 2 2 2 1 HAP1 N-terminal conserved region HrpB7 PF09486.10 KII63266.1 - 0.012 16.0 24.6 0.27 11.6 14.8 2.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) AAA_22 PF13401.6 KII63266.1 - 0.015 15.6 2.3 0.035 14.4 0.2 2.8 2 1 0 2 2 2 0 AAA domain Cast PF10174.9 KII63266.1 - 0.086 11.1 44.3 0.0056 15.0 37.2 1.9 1 1 1 2 2 2 0 RIM-binding protein of the cytomatrix active zone DUF5082 PF16888.5 KII63266.1 - 0.087 13.1 32.3 0.68 10.2 15.7 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) AAA_16 PF13191.6 KII63266.1 - 0.12 12.8 2.4 0.95 9.8 0.0 3.0 2 1 0 2 2 2 0 AAA ATPase domain Lebercilin PF15619.6 KII63266.1 - 0.15 11.7 47.9 0.24 11.0 27.9 2.6 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease PspA_IM30 PF04012.12 KII63266.1 - 0.18 11.3 42.3 0.58 9.7 8.0 2.9 1 1 1 2 2 2 0 PspA/IM30 family AAA_13 PF13166.6 KII63266.1 - 0.2 10.2 35.3 0.086 11.5 18.5 2.4 1 1 1 2 2 2 0 AAA domain CALCOCO1 PF07888.11 KII63266.1 - 0.23 10.3 39.7 0.44 9.3 39.7 1.4 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6_N PF17675.1 KII63266.1 - 0.26 11.8 50.3 1.9 9.0 7.7 3.9 1 1 1 3 3 3 0 Apg6 coiled-coil region Laminin_II PF06009.12 KII63266.1 - 0.78 9.8 36.0 1.9 8.5 3.3 3.8 1 1 2 3 3 3 0 Laminin Domain II DHR10 PF18595.1 KII63266.1 - 1.1 9.3 49.1 1.1 9.4 7.4 3.9 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain CLZ PF16526.5 KII63266.1 - 4.3 7.8 36.0 0.36 11.2 3.5 4.6 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Spc7 PF08317.11 KII63266.1 - 5.5 5.8 48.4 0.87 8.4 20.5 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein FUSC PF04632.12 KII63266.1 - 6.9 5.1 6.2 11 4.3 6.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Jnk-SapK_ap_N PF09744.9 KII63266.1 - 7.8 6.7 43.8 0.074 13.3 15.8 3.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 BRE1 PF08647.11 KII63266.1 - 8.6 6.5 53.3 2 8.6 16.0 4.2 3 1 1 4 4 3 0 BRE1 E3 ubiquitin ligase ADIP PF11559.8 KII63266.1 - 9.3 6.3 40.5 0.13 12.4 8.7 3.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding ORC5_C PF14630.6 KII63267.1 - 4.2e-23 82.3 0.2 5.6e-23 81.9 0.2 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus zf-CCHC PF00098.23 KII63268.1 - 3.4e-05 23.7 0.9 5.4e-05 23.1 0.9 1.3 1 0 0 1 1 1 1 Zinc knuckle Cnn_1N PF07989.11 KII63268.1 - 0.045 13.9 0.5 0.15 12.2 0.1 1.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 RVP PF00077.20 KII63268.1 - 0.12 12.7 0.1 0.33 11.3 0.1 1.7 2 0 0 2 2 2 0 Retroviral aspartyl protease zf-C2H2_10 PF16588.5 KII63268.1 - 0.12 12.1 0.7 0.22 11.3 0.7 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger UQ_con PF00179.26 KII63270.1 - 3.1e-21 75.5 0.0 3.7e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KII63270.1 - 0.062 13.6 0.0 0.081 13.2 0.0 1.2 1 0 0 1 1 1 0 RWD domain zf-CCHC PF00098.23 KII63273.1 - 6.4e-08 32.3 7.0 3.1e-05 23.8 1.0 4.3 4 1 0 3 3 3 2 Zinc knuckle zf-CCCH_3 PF15663.5 KII63273.1 - 2.4e-05 24.5 14.8 6.5e-05 23.1 5.3 3.0 1 1 0 2 2 2 2 Zinc-finger containing family zf-CCCH PF00642.24 KII63273.1 - 4.6e-05 23.2 3.8 4.6e-05 23.2 3.8 4.5 5 0 0 5 5 5 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KII63273.1 - 0.0024 18.5 18.7 0.017 15.8 4.1 3.3 1 1 2 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 KII63273.1 - 0.0034 17.4 32.2 0.011 15.8 7.9 4.9 5 0 0 5 5 5 2 Zinc finger domain zf-CCCH_4 PF18044.1 KII63273.1 - 0.025 14.4 7.7 0.025 14.4 7.7 4.3 4 0 0 4 4 4 0 CCCH-type zinc finger zf-CCHC_2 PF13696.6 KII63273.1 - 0.051 13.4 1.8 0.051 13.4 1.8 4.2 5 0 0 5 5 5 0 Zinc knuckle zf-CCCH_2 PF14608.6 KII63273.1 - 0.11 13.0 1.7 0.11 13.0 1.7 5.3 4 1 0 4 4 4 0 RNA-binding, Nab2-type zinc finger zf-CCHC_4 PF14392.6 KII63273.1 - 0.22 11.3 5.1 2.5 7.9 0.3 2.8 2 0 0 2 2 2 0 Zinc knuckle DUF2443 PF10398.9 KII63274.1 - 0.0099 15.9 1.4 0.016 15.3 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2443) Homoserine_dh PF00742.19 KII63274.1 - 0.093 12.6 0.1 0.13 12.1 0.1 1.3 1 1 0 1 1 1 0 Homoserine dehydrogenase ALMT PF11744.8 KII63274.1 - 0.26 10.1 3.8 0.29 9.9 3.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter T3SchapCesA PF11439.8 KII63274.1 - 0.31 11.2 3.7 1.6 8.9 3.7 2.0 1 1 0 1 1 1 0 Type III secretion system filament chaperone CesA RVT_1 PF00078.27 KII63276.1 - 4.2e-27 95.1 0.1 1e-26 93.8 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII63276.1 - 1.6e-06 27.9 11.2 0.0011 19.0 2.0 2.5 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII63276.1 - 1e-05 25.7 0.0 7.4e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII63276.1 - 0.00015 22.3 0.0 0.00034 21.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII63276.1 - 0.00019 21.9 0.0 0.00041 20.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII63276.1 - 0.0004 20.2 0.1 0.0014 18.4 0.1 2.0 1 1 0 1 1 1 1 Aspartyl protease zf-CCHC_3 PF13917.6 KII63276.1 - 0.0021 18.0 5.9 0.01 15.8 0.5 2.5 1 1 1 2 2 2 1 Zinc knuckle RVP_2 PF08284.11 KII63276.1 - 0.0023 17.7 0.3 0.0046 16.7 0.3 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Herpes_UL14 PF03580.14 KII63276.1 - 0.03 14.6 0.6 0.07 13.4 0.0 1.8 2 0 0 2 2 2 0 Herpesvirus UL14-like protein Peptidase_A2B PF12384.8 KII63276.1 - 0.035 13.7 0.1 0.22 11.0 0.0 2.1 1 1 1 2 2 2 0 Ty3 transposon peptidase Zn_Tnp_IS91 PF14319.6 KII63276.1 - 0.04 13.9 3.7 0.16 12.0 3.7 2.0 1 0 0 1 1 1 0 Transposase zinc-binding domain Spuma_A9PTase PF03539.14 KII63276.1 - 0.042 14.0 0.0 0.078 13.1 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) PHD_4 PF16866.5 KII63276.1 - 0.17 12.0 2.4 0.8 9.8 1.7 2.4 1 1 1 2 2 2 0 PHD-finger zf-CCHC_5 PF14787.6 KII63276.1 - 0.82 9.4 9.3 5.1 6.9 1.7 2.6 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-ribbon_3 PF13248.6 KII63276.1 - 2.7 7.5 5.4 9.3 5.8 0.5 2.6 2 0 0 2 2 2 0 zinc-ribbon domain CoA_binding_3 PF13727.6 KII63277.1 - 0.66 10.0 6.2 2.4 8.1 6.1 1.8 1 1 0 1 1 1 0 CoA-binding domain EbsA PF17255.2 KII63277.1 - 2.2 8.6 8.0 0.49 10.7 4.9 1.5 2 0 0 2 2 2 0 EbsA-like protein Lectin_C PF00059.21 KII63279.1 - 1.3e-14 54.9 1.6 3.3e-14 53.5 1.6 1.8 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 KII63279.1 - 0.005 16.5 0.1 0.01 15.5 0.1 1.5 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like F5_F8_type_C PF00754.25 KII63279.1 - 0.01 16.0 0.4 0.06 13.5 0.1 2.2 2 0 0 2 2 2 0 F5/8 type C domain SNAP PF14938.6 KII63280.1 - 2.7e-06 27.0 2.4 3.3e-06 26.7 2.4 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII63280.1 - 0.046 13.9 7.1 0.51 10.7 0.1 4.1 2 1 2 4 4 4 0 Tetratricopeptide repeat Agro_virD5 PF04730.12 KII63281.1 - 0.16 10.5 0.0 0.2 10.2 0.0 1.1 1 0 0 1 1 1 0 Agrobacterium VirD5 protein Tyr_Deacylase PF02580.16 KII63282.1 - 1e-17 65.0 0.1 1.1e-17 64.9 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase ERAP1_C PF11838.8 KII63283.1 - 4.8e-24 85.5 0.0 5.4e-24 85.3 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 KII63284.1 - 0.00039 20.0 0.1 0.00052 19.6 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain RNHCP PF12647.7 KII63284.1 - 0.036 14.0 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 RNHCP domain Peptidase_M1_N PF17900.1 KII63285.1 - 8.5e-36 123.9 2.8 1.1e-35 123.5 2.8 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 KII63285.1 - 9.9e-20 71.0 0.0 3.1e-19 69.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M1 domain CaiF_GrlA PF07180.11 KII63285.1 - 0.14 12.1 0.2 0.34 10.9 0.0 1.7 2 0 0 2 2 2 0 CaiF/GrlA transcriptional regulator ERAP1_C PF11838.8 KII63286.1 - 1.7e-07 31.1 0.0 1.9e-07 30.9 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain DUF3922 PF13059.6 KII63286.1 - 0.083 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) ArgoMid PF16487.5 KII63289.1 - 0.024 14.9 1.0 2.4 8.5 0.1 2.5 2 0 0 2 2 2 0 Mid domain of argonaute DASH_Duo1 PF08651.10 KII63289.1 - 0.031 14.1 0.1 0.081 12.7 0.1 1.7 1 0 0 1 1 1 0 DASH complex subunit Duo1 rve PF00665.26 KII63290.1 - 0.00032 20.9 0.0 0.00072 19.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF3024 PF11225.8 KII63292.1 - 0.2 11.9 1.0 1.6 9.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3024) CENP-B_dimeris PF09026.10 KII63292.1 - 1.9 8.9 9.3 3.2 8.2 9.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain 7tm_1 PF00001.21 KII63293.1 - 1.4e-15 57.4 17.6 1.8e-15 57.0 17.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3598 PF12204.8 KII63294.1 - 0.048 13.2 0.0 0.13 11.7 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3598) DDE_3 PF13358.6 KII63296.1 - 5e-25 88.0 0.0 6.9e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII63296.1 - 0.00013 22.1 0.0 0.0011 19.1 0.0 2.2 2 0 0 2 2 2 1 Transposase rve PF00665.26 KII63296.1 - 0.1 12.8 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain HTH_33 PF13592.6 KII63296.1 - 0.18 11.4 0.0 0.46 10.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix SNAP PF14938.6 KII63297.1 - 2.1e-08 33.9 1.0 2.4e-08 33.7 1.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TRC8_N PF13705.6 KII63297.1 - 0.016 14.1 0.2 0.019 13.9 0.2 1.1 1 0 0 1 1 1 0 TRC8 N-terminal domain Peptidase_S7 PF00949.21 KII63297.1 - 0.058 13.2 0.1 3.2 7.6 0.0 2.2 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease DUF4259 PF14078.6 KII63297.1 - 0.063 14.0 0.0 0.093 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4259) TPR_2 PF07719.17 KII63297.1 - 0.11 12.7 0.0 0.46 10.7 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KII63297.1 - 0.13 13.1 0.0 0.41 11.6 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat PRANC PF09372.10 KII63300.1 - 0.05 13.9 3.1 0.66 10.3 1.9 2.0 1 1 1 2 2 2 0 PRANC domain Fumarate_red_C PF02300.17 KII63303.1 - 0.011 15.8 0.0 0.015 15.4 0.0 1.2 1 0 0 1 1 1 0 Fumarate reductase subunit C SNAP PF14938.6 KII63305.1 - 0.014 14.8 2.7 0.014 14.8 2.7 1.3 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP NSF PF02071.20 KII63305.1 - 0.54 11.2 11.0 31 6.0 0.5 4.8 4 1 1 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat DUF4371 PF14291.6 KII63306.1 - 0.00083 19.1 0.1 0.0011 18.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Tho1_MOS11_C PF18592.1 KII63306.1 - 0.11 12.3 0.1 0.38 10.6 0.1 1.9 1 0 0 1 1 1 0 Tho1/MOS11 C-terminal domain SNAP PF14938.6 KII63307.1 - 1.7e-07 31.0 0.4 3.1e-07 30.1 0.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF5526 PF17664.1 KII63307.1 - 0.4 10.2 1.7 13 5.3 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5526) PurA PF04845.13 KII63309.1 - 1.3e-14 54.1 0.3 2.4e-10 40.1 0.1 2.3 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein DUF3970 PF13113.6 KII63309.1 - 0.052 13.8 0.0 0.3 11.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) Ribosomal_S25 PF03297.15 KII63312.1 - 2.7e-26 91.7 6.5 2.7e-26 91.7 6.5 2.0 1 1 1 2 2 2 1 S25 ribosomal protein SAND PF01342.21 KII63313.1 - 4e-26 90.5 0.2 8.7e-26 89.4 0.2 1.6 1 0 0 1 1 1 1 SAND domain zf-MYND PF01753.18 KII63313.1 - 3.2e-09 36.7 15.9 8e-09 35.4 15.9 1.7 1 0 0 1 1 1 1 MYND finger ATP-synt PF00231.19 KII63313.1 - 0.061 13.1 0.6 0.11 12.2 0.6 1.3 1 0 0 1 1 1 0 ATP synthase PolC_DP2 PF03833.13 KII63313.1 - 0.31 8.8 3.5 0.45 8.3 3.5 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Pkinase PF00069.25 KII63314.1 - 1.4e-73 247.5 0.0 1.6e-73 247.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII63314.1 - 6.8e-32 110.8 0.0 8.5e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KII63314.1 - 6.3e-05 22.1 0.0 0.00015 20.8 0.0 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 KII63314.1 - 0.00067 19.1 0.0 0.00098 18.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KII63314.1 - 0.0011 19.0 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KII63314.1 - 0.059 12.7 0.1 0.12 11.7 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Exo_endo_phos PF03372.23 KII63315.1 - 2.1e-23 83.1 0.2 2.5e-23 82.8 0.2 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KII63315.1 - 2.4e-07 30.6 0.1 7.2e-07 29.1 0.1 1.8 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase AA_permease_2 PF13520.6 KII63316.1 - 3.6e-43 148.0 56.8 4.5e-43 147.7 56.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII63316.1 - 2.7e-22 79.0 51.4 6.6e-22 77.7 51.3 1.5 1 1 0 1 1 1 1 Amino acid permease ALMT PF11744.8 KII63316.1 - 3.5 6.4 8.7 6.7 5.4 8.7 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter LAP1C PF05609.12 KII63319.1 - 0.35 9.9 22.7 0.49 9.4 22.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 KII63323.1 - 0.025 12.9 6.4 0.03 12.7 6.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Endostatin PF06482.11 KII63323.1 - 0.28 10.6 5.5 0.35 10.3 5.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Serglycin PF04360.12 KII63323.1 - 0.41 10.6 8.8 2.2 8.2 8.8 2.0 1 1 0 1 1 1 0 Serglycin Neur_chan_memb PF02932.16 KII63323.1 - 2.9 7.9 4.8 3.6 7.6 4.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 KII63323.1 - 3 6.5 15.4 4.4 6.0 15.4 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 KII63323.1 - 4 6.4 11.1 4.9 6.1 11.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SDA1 PF05285.12 KII63323.1 - 5.2 6.4 17.4 6.7 6.0 17.4 1.2 1 0 0 1 1 1 0 SDA1 ALMT PF11744.8 KII63323.1 - 6.2 5.5 10.3 8.6 5.1 10.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 KII63323.1 - 7.2 4.6 11.9 8.6 4.3 11.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UAA PF08449.11 KII63324.1 - 7.9e-21 74.5 28.8 1.1e-20 74.0 28.8 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KII63324.1 - 0.00077 19.6 13.5 0.00077 19.6 13.5 2.7 2 1 1 3 3 3 1 EamA-like transporter family TPT PF03151.16 KII63324.1 - 0.0076 15.6 18.4 0.016 14.6 18.4 1.5 1 1 0 1 1 1 1 Triose-phosphate Transporter family CRT-like PF08627.10 KII63324.1 - 0.72 8.7 27.2 0.44 9.4 3.0 2.9 1 1 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like Ribosomal_L7Ae PF01248.26 KII63326.1 - 4.8e-08 32.6 0.1 7.2e-08 32.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 KII63326.1 - 5.2e-05 23.3 0.1 6.2e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 Sec7 PF01369.20 KII63327.1 - 4.8e-62 208.9 3.5 4.8e-62 208.9 3.5 2.4 2 0 0 2 2 2 1 Sec7 domain DUF1981 PF09324.10 KII63327.1 - 5.9e-21 74.1 1.2 5.9e-21 74.1 1.2 5.5 5 1 1 6 6 6 1 Domain of unknown function (DUF1981) Sec7_N PF12783.7 KII63327.1 - 1.2e-14 54.5 12.4 1.2e-14 54.5 12.4 3.9 6 0 0 6 6 6 1 Guanine nucleotide exchange factor in Golgi transport N-terminal IBN_N PF03810.19 KII63327.1 - 0.065 13.2 1.5 6.1 6.8 0.1 3.8 3 0 0 3 3 3 0 Importin-beta N-terminal domain Ipi1_N PF12333.8 KII63327.1 - 0.59 10.8 5.7 0.98 10.1 0.0 4.3 5 0 0 5 5 5 0 Rix1 complex component involved in 60S ribosome maturation DnaB_2 PF07261.11 KII63333.1 - 0.11 12.2 0.1 0.27 11.0 0.1 1.6 2 0 0 2 2 2 0 Replication initiation and membrane attachment PSA_CBD PF18341.1 KII63335.1 - 0.004 17.2 0.3 0.3 11.1 0.1 2.3 1 1 1 2 2 2 2 PSA endolysin C-terminal cell wall binding domain SRP72 PF08492.12 KII63337.1 - 2.2e-13 50.4 8.8 2.2e-13 50.4 8.8 2.1 1 1 0 1 1 1 1 SRP72 RNA-binding domain Fis1_TPR_C PF14853.6 KII63337.1 - 0.062 13.4 0.1 10 6.3 0.0 3.0 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Ribosomal_L27e PF01777.18 KII63337.1 - 1.1 9.7 5.8 0.62 10.4 0.5 3.0 2 1 0 2 2 2 0 Ribosomal L27e protein family DUF4412 PF14371.6 KII63339.1 - 0.11 12.3 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4412) H_kinase_N PF12282.8 KII63340.1 - 0.071 13.1 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Signal transduction histidine kinase DUF1489 PF07370.11 KII63340.1 - 0.075 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) Ras PF00071.22 KII63341.1 - 1.3e-09 37.9 0.1 1.9e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII63341.1 - 0.046 13.9 0.1 0.086 13.1 0.1 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 KII63342.1 - 0.0024 17.2 0.0 0.0032 16.8 0.0 1.1 1 0 0 1 1 1 1 Septin DUF815 PF05673.13 KII63342.1 - 0.0032 16.7 0.0 0.0038 16.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 KII63342.1 - 0.0033 16.9 0.1 0.0042 16.6 0.1 1.4 1 1 0 1 1 1 1 P-loop containing dynein motor region Roc PF08477.13 KII63342.1 - 0.0046 17.2 0.1 0.0076 16.5 0.1 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KII63342.1 - 0.018 15.1 0.0 0.03 14.4 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 KII63342.1 - 0.023 14.0 0.2 0.029 13.7 0.2 1.3 1 1 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 KII63342.1 - 0.034 13.9 0.1 0.068 12.9 0.1 1.5 1 1 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 KII63342.1 - 0.039 13.4 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 KII63342.1 - 0.054 13.8 0.0 0.076 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 KII63342.1 - 0.06 12.9 0.1 0.083 12.4 0.1 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 KII63342.1 - 0.062 13.3 0.0 0.082 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KII63342.1 - 0.064 12.6 0.1 0.09 12.1 0.1 1.3 1 0 0 1 1 1 0 KaiC Bromodomain PF00439.25 KII63347.1 - 1.2e-11 44.5 2.5 1.7e-11 44.0 0.3 2.4 2 0 0 2 2 2 1 Bromodomain PKcGMP_CC PF16808.5 KII63347.1 - 0.065 13.1 0.6 0.19 11.6 0.6 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF2443 PF10398.9 KII63347.1 - 0.073 13.1 3.3 0.29 11.2 3.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) NPR1_interact PF15699.5 KII63347.1 - 0.26 11.9 3.7 0.89 10.2 0.1 2.9 3 0 0 3 3 3 0 NPR1 interacting BLOC1_2 PF10046.9 KII63347.1 - 0.77 10.1 7.9 2.3 8.6 0.3 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1690 PF07956.11 KII63347.1 - 5.7 7.4 8.7 1.7 9.1 3.6 2.4 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) FANCI_S4 PF14678.6 KII63348.1 - 4.2e-22 78.5 4.1 4.2e-22 78.5 4.1 2.0 2 0 0 2 2 2 2 FANCI solenoid 4 Spo0M PF07070.11 KII63348.1 - 0.039 13.5 0.0 0.057 13.0 0.0 1.2 1 0 0 1 1 1 0 SpoOM protein DDE_3 PF13358.6 KII63349.1 - 0.0039 17.0 0.0 0.0059 16.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease LRR19-TM PF15176.6 KII63351.1 - 0.087 12.8 1.2 0.14 12.2 0.4 1.7 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain WH2 PF02205.20 KII63353.1 - 0.00069 19.4 0.1 0.0013 18.5 0.1 1.5 1 0 0 1 1 1 1 WH2 motif BLYB PF05289.11 KII63355.1 - 0.077 13.2 0.2 0.19 12.0 0.2 1.7 1 0 0 1 1 1 0 Borrelia hemolysin accessory protein CDP-OH_P_transf PF01066.21 KII63355.1 - 4.8 8.0 7.2 0.45 11.3 1.2 2.4 1 1 1 2 2 2 0 CDP-alcohol phosphatidyltransferase Kelch_6 PF13964.6 KII63356.1 - 0.11 12.8 2.0 0.18 12.2 0.3 2.1 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 KII63357.1 - 2e-24 85.0 15.5 2.4e-05 24.5 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII63357.1 - 4.9e-19 68.1 21.4 2e-05 24.5 0.2 7.3 6 2 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 KII63357.1 - 1.3e-18 66.3 21.6 0.00061 19.3 0.1 6.5 6 1 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KII63357.1 - 3e-14 52.9 15.3 0.0001 22.5 0.0 7.1 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII63357.1 - 3.8e-13 49.1 17.4 0.0013 18.7 0.2 6.3 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 KII63357.1 - 8.8e-08 31.8 13.5 3.9 7.6 1.0 6.6 6 1 0 6 6 6 5 Kelch motif zf-UBR PF02207.20 KII63362.1 - 2.1e-08 34.2 17.0 2.4e-08 34.0 14.4 2.0 1 1 1 2 2 2 2 Putative zinc finger in N-recognin (UBR box) DDE_3 PF13358.6 KII63364.1 - 0.0025 17.6 0.0 0.17 11.6 0.0 2.1 2 0 0 2 2 2 2 DDE superfamily endonuclease Ribosomal_L12 PF00542.19 KII63367.1 - 2.4e-21 75.8 0.6 2.4e-21 75.8 0.6 1.8 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 KII63367.1 - 5.7e-11 42.0 0.5 3.7e-10 39.3 0.0 2.3 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain Herpes_LMP1 PF05297.11 KII63369.1 - 0.38 9.9 2.8 0.48 9.6 2.8 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) COMM_domain PF07258.14 KII63370.1 - 0.0023 18.0 0.0 0.0044 17.1 0.0 1.5 1 0 0 1 1 1 1 COMM domain PfUIS3 PF11567.8 KII63370.1 - 0.075 13.4 0.1 0.16 12.3 0.1 1.6 1 1 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein ARPC4 PF05856.12 KII63371.1 - 1.2e-73 246.2 7.9 1.3e-73 246.1 7.9 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) DUF4547 PF15080.6 KII63371.1 - 0.00055 19.6 0.3 0.00062 19.5 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4547) LETM1 PF07766.13 KII63374.1 - 4.4e-08 32.8 0.9 6.7e-08 32.2 0.9 1.4 1 0 0 1 1 1 1 LETM1-like protein LETM1 PF07766.13 KII63375.1 - 1.9e-12 47.1 0.1 2.6e-12 46.6 0.1 1.2 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.27 KII63375.1 - 0.025 14.3 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 SAP domain Ribosomal_L11 PF00298.19 KII63376.1 - 5.4e-20 71.7 0.0 8.7e-20 71.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 KII63376.1 - 0.012 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain DDE_Tnp_IS1595 PF12762.7 KII63377.1 - 3.3e-15 56.4 0.1 3.9e-15 56.2 0.1 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain ArfGap PF01412.18 KII63381.1 - 8.1e-29 100.1 0.2 6.2e-28 97.2 0.3 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf TackOD1 PF18551.1 KII63381.1 - 0.0095 15.6 0.4 0.017 14.8 0.4 1.4 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Tn916-Xis PF09035.10 KII63381.1 - 0.095 12.9 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 Excisionase from transposon Tn916 SNAP PF14938.6 KII63382.1 - 2.2e-11 43.7 4.3 4.1e-11 42.8 3.7 1.7 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP Reprolysin_2 PF13574.6 KII63383.1 - 1.6e-10 41.2 0.0 4.5e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KII63383.1 - 5.8e-10 39.7 0.1 5.8e-10 39.7 0.1 2.3 2 0 0 2 2 2 1 Metallo-peptidase family M12 Disintegrin PF00200.23 KII63383.1 - 2.6e-09 37.7 21.5 2.6e-09 37.7 21.5 3.5 2 1 1 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 KII63383.1 - 4.4e-06 27.2 0.8 3.2e-05 24.4 0.1 2.5 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KII63383.1 - 0.0037 16.9 0.0 0.0067 16.1 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M56 PF05569.11 KII63383.1 - 0.076 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 HC2 PF07382.11 KII63385.1 - 4.3e-17 62.8 46.1 3.9e-09 36.9 22.0 2.0 1 1 1 2 2 2 2 Histone H1-like nucleoprotein HC2 PMG PF05287.12 KII63385.1 - 0.048 13.7 27.4 0.48 10.4 27.6 1.9 1 1 0 1 1 1 0 PMG protein Keratin_B2 PF01500.17 KII63385.1 - 3.4 7.7 50.4 1.6e+02 2.2 50.4 2.4 1 1 0 1 1 1 0 Keratin, high sulfur B2 protein RhoGAP PF00620.27 KII63386.1 - 9.6e-42 142.4 0.7 4.6e-41 140.2 0.0 2.1 3 0 0 3 3 3 1 RhoGAP domain Npa1 PF11707.8 KII63386.1 - 0.03 13.7 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal Cullin_binding PF03556.15 KII63386.1 - 0.043 14.3 0.2 0.16 12.4 0.1 1.9 2 0 0 2 2 2 0 Cullin binding DUF1043 PF06295.12 KII63387.1 - 0.018 15.0 4.4 0.025 14.6 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) WD-3 PF09765.9 KII63387.1 - 0.02 14.2 1.3 0.021 14.2 1.3 1.1 1 0 0 1 1 1 0 WD-repeat region DUF3785 PF12653.7 KII63387.1 - 0.02 15.0 0.7 0.025 14.7 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3785) Ntox28 PF15605.6 KII63387.1 - 0.029 14.6 1.8 0.037 14.3 0.2 1.9 1 1 1 2 2 2 0 Bacterial toxin 28 CDT1_C PF16679.5 KII63387.1 - 0.031 14.7 1.3 0.043 14.2 1.3 1.3 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain DUF4400 PF14348.6 KII63387.1 - 0.071 12.6 0.2 0.091 12.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) Tae4 PF14113.6 KII63387.1 - 0.089 13.0 2.3 0.37 11.0 2.3 1.9 1 1 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 ArAE_2_N PF10337.9 KII63387.1 - 0.34 9.9 2.0 0.4 9.7 2.0 1.0 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Tho1_MOS11_C PF18592.1 KII63387.1 - 0.41 10.5 3.6 0.7 9.8 0.6 2.4 2 1 1 3 3 3 0 Tho1/MOS11 C-terminal domain Ras PF00071.22 KII63388.1 - 7.1e-05 22.5 1.2 0.0058 16.2 0.2 3.2 3 0 0 3 3 3 2 Ras family GTP_EFTU PF00009.27 KII63388.1 - 0.011 15.3 0.5 0.025 14.1 0.1 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF4258 PF14076.6 KII63388.1 - 0.091 13.1 0.2 1.6 9.2 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4258) 7tm_3 PF00003.22 KII63390.1 - 0.025 14.3 8.7 0.032 14.0 8.7 1.1 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR SNAP PF14938.6 KII63391.1 - 1.3e-08 34.6 0.2 1.6e-08 34.3 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP HEPN PF05168.14 KII63391.1 - 0.055 13.6 0.3 0.096 12.8 0.3 1.4 1 1 0 1 1 1 0 HEPN domain zf-CCHC PF00098.23 KII63395.1 - 7.8e-07 28.9 11.1 0.004 17.2 5.2 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 KII63395.1 - 0.12 12.2 12.7 0.11 12.3 5.0 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII63395.1 - 0.14 12.0 7.6 0.67 9.7 0.8 2.5 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 KII63396.1 - 2.1e-20 73.1 0.1 3.1e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63396.1 - 5.3e-07 29.6 0.9 2.2e-06 27.7 0.6 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII63396.1 - 1.1e-05 25.1 0.0 2.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII63396.1 - 0.00092 19.4 0.1 0.0017 18.6 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger DDE_3 PF13358.6 KII63396.1 - 0.0025 17.6 0.1 0.0043 16.8 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Nepo_coat_N PF03689.15 KII63396.1 - 0.014 15.4 0.1 0.11 12.4 0.0 2.3 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain SMC_N PF02463.19 KII63397.1 - 0.1 12.0 0.2 0.13 11.7 0.2 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 KII63397.1 - 0.11 13.1 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter ABC_membrane PF00664.23 KII63398.1 - 8.5e-43 147.0 53.9 8.2e-22 78.1 26.0 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KII63398.1 - 1.2e-18 67.9 0.0 3.7e-18 66.4 0.0 1.9 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KII63398.1 - 4.3e-06 26.3 0.1 0.033 13.6 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KII63398.1 - 0.00026 20.9 0.0 0.59 9.9 0.1 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KII63398.1 - 0.0022 18.6 0.0 0.0055 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 KII63398.1 - 0.011 15.5 0.1 0.011 15.5 0.1 2.3 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 KII63398.1 - 0.023 14.4 0.1 0.054 13.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KII63398.1 - 0.041 14.2 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 KII63398.1 - 0.087 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Dynamin family NACHT PF05729.12 KII63398.1 - 0.16 11.9 0.0 0.57 10.1 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 KII63398.1 - 0.16 12.4 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_27 PF13514.6 KII63398.1 - 0.19 11.3 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Med6 PF04934.14 KII63400.1 - 8.2e-34 116.3 0.5 1.1e-33 115.9 0.5 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component Proteasome PF00227.26 KII63401.1 - 2.8e-47 160.7 0.0 3.5e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KII63401.1 - 5.5e-13 48.3 0.0 1.1e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature vATP-synt_E PF01991.18 KII63402.1 - 8.3e-57 191.8 6.8 9.9e-57 191.6 6.8 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit P66_CC PF16563.5 KII63402.1 - 0.018 14.7 2.0 0.072 12.7 2.0 2.1 1 0 0 1 1 1 0 Coiled-coil and interaction region of P66A and P66B with MBD2 Tn7_Tnp_TnsA_C PF08721.11 KII63402.1 - 0.11 13.2 0.3 0.11 13.2 0.3 2.0 3 0 0 3 3 3 0 TnsA endonuclease C terminal OmpH PF03938.14 KII63402.1 - 0.29 11.5 10.2 0.41 11.0 10.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DDE_Tnp_4 PF13359.6 KII63403.1 - 0.059 13.0 0.1 0.079 12.6 0.1 1.3 1 1 0 1 1 1 0 DDE superfamily endonuclease Suf PF05843.14 KII63404.1 - 9.3e-19 68.5 0.4 1.6e-18 67.7 0.2 1.4 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) ERO1 PF04137.15 KII63404.1 - 0.021 14.0 0.2 0.022 14.0 0.2 1.1 1 0 0 1 1 1 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Suf PF05843.14 KII63405.1 - 9.7e-05 22.5 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) CBM49 PF09478.10 KII63406.1 - 0.012 15.9 0.2 0.021 15.1 0.2 1.4 1 1 0 1 1 1 0 Carbohydrate binding domain CBM49 Ca_hom_mod PF14798.6 KII63407.1 - 0.02 14.0 0.0 0.034 13.2 0.0 1.3 1 0 0 1 1 1 0 Calcium homeostasis modulator SecD-TM1 PF13721.6 KII63407.1 - 0.086 13.3 1.1 2.8 8.5 0.3 2.5 2 0 0 2 2 2 0 SecD export protein N-terminal TM region NUDIX PF00293.28 KII63408.1 - 1.1e-07 31.9 0.0 1.6e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain KH_1 PF00013.29 KII63409.1 - 0.0006 19.6 0.0 0.1 12.4 0.0 2.4 2 0 0 2 2 2 2 KH domain NUDIX PF00293.28 KII63410.1 - 2.6e-05 24.3 0.0 4.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Apo-CIII PF05778.12 KII63410.1 - 0.13 11.9 0.1 0.23 11.1 0.1 1.3 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) DDE_3 PF13358.6 KII63411.1 - 0.0099 15.6 0.0 0.017 14.9 0.0 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease RhoGEF PF00621.20 KII63412.1 - 1.4e-12 48.3 12.1 1.5e-12 48.1 10.6 1.7 1 1 1 2 2 2 1 RhoGEF domain Bcl-2 PF00452.19 KII63412.1 - 0.097 13.4 0.0 0.37 11.5 0.0 1.8 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family Ras PF00071.22 KII63413.1 - 0.0036 16.9 0.1 0.0049 16.5 0.1 1.2 1 0 0 1 1 1 1 Ras family RelB PF04221.12 KII63413.1 - 0.068 13.1 0.2 1.2 9.2 0.1 2.1 2 0 0 2 2 2 0 RelB antitoxin Arf PF00025.21 KII63414.1 - 6.4e-63 211.4 0.0 7.5e-63 211.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KII63414.1 - 5.8e-16 58.5 0.0 6.7e-16 58.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII63414.1 - 1.8e-15 57.2 0.1 2.4e-15 56.8 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KII63414.1 - 5.6e-12 45.5 0.0 6.9e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KII63414.1 - 1.9e-10 40.4 2.8 7.4e-08 31.9 1.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KII63414.1 - 7.6e-10 38.5 0.0 9.1e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KII63414.1 - 3.5e-07 30.3 0.0 4.6e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KII63414.1 - 3.6e-05 23.4 0.0 0.00011 21.8 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain 6PF2K PF01591.18 KII63414.1 - 0.00052 19.4 0.1 0.011 15.1 0.1 2.0 2 0 0 2 2 2 1 6-phosphofructo-2-kinase AAA_16 PF13191.6 KII63414.1 - 0.15 12.4 0.1 1.5 9.2 0.0 2.0 1 1 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.18 KII63414.1 - 0.17 11.4 0.2 0.35 10.4 0.2 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B CHCH PF06747.13 KII63416.1 - 1.3e-06 28.3 3.5 2.6e-06 27.4 3.5 1.5 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 KII63416.1 - 0.0026 17.7 1.6 0.0038 17.2 1.6 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, GCK PF07802.11 KII63416.1 - 0.014 15.8 1.7 0.021 15.3 1.7 1.2 1 0 0 1 1 1 0 GCK domain Piezo_RRas_bdg PF12166.8 KII63417.1 - 3e-32 112.5 4.8 3e-32 112.5 4.8 2.2 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain PIEZO PF15917.5 KII63417.1 - 0.045 13.2 0.2 0.13 11.7 0.2 1.7 1 0 0 1 1 1 0 Piezo DDE_1 PF03184.19 KII63419.1 - 0.084 12.5 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease RNA_pol_Rpb1_5 PF04998.17 KII63420.1 - 1.6e-86 290.1 2.6 1.5e-85 286.9 2.6 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KII63420.1 - 2.3e-59 200.3 0.9 6.5e-59 198.9 0.9 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KII63420.1 - 1.3e-32 112.9 0.0 6e-31 107.5 0.0 3.3 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KII63420.1 - 2.7e-23 82.0 0.3 1.4e-22 79.7 0.3 2.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.12 KII63420.1 - 9.3e-22 77.7 0.5 9.3e-22 77.7 0.5 3.6 4 0 0 4 4 4 2 RNA polymerase Rpb1, domain 1 Haem_bd PF14376.6 KII63420.1 - 0.02 14.8 0.0 0.06 13.3 0.0 1.8 1 0 0 1 1 1 0 Haem-binding domain DUF1828 PF08861.10 KII63420.1 - 0.62 10.4 2.8 0.87 9.9 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF1828 Mito_carr PF00153.27 KII63422.1 - 2.8e-37 126.5 0.6 6.7e-20 70.8 0.0 2.1 1 1 1 2 2 2 2 Mitochondrial carrier protein Antimicrobial20 PF08256.11 KII63422.1 - 0.016 15.6 0.5 0.25 12.0 0.0 3.1 3 0 0 3 3 3 0 Aurein-like antibiotic peptide Serine_protease PF18405.1 KII63422.1 - 0.034 13.3 0.0 0.055 12.6 0.0 1.4 1 0 0 1 1 1 0 Gammaproteobacterial serine protease Sugar_tr PF00083.24 KII63423.1 - 8.6e-12 44.6 8.8 3.3e-11 42.7 4.1 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter ATP_bind_1 PF03029.17 KII63424.1 - 3.8e-11 43.2 0.0 5.4e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein FliD_C PF07195.12 KII63424.1 - 0.016 14.6 0.9 0.019 14.4 0.9 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus ATP_bind_1 PF03029.17 KII63425.1 - 2.3e-26 93.1 0.1 3.5e-26 92.5 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein T2SSE PF00437.20 KII63425.1 - 0.00016 20.9 0.0 0.00018 20.7 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA12 PF10443.9 KII63425.1 - 0.00029 19.7 0.0 0.00032 19.6 0.0 1.1 1 0 0 1 1 1 1 RNA12 protein NB-ARC PF00931.22 KII63425.1 - 0.00063 19.0 0.1 0.00083 18.6 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.6 KII63425.1 - 0.0069 16.7 0.1 0.0088 16.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII63425.1 - 0.0096 16.3 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 KII63425.1 - 0.02 14.8 0.1 0.026 14.4 0.1 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 KII63425.1 - 0.025 14.3 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 KII63425.1 - 0.032 14.0 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF87 PF01935.17 KII63425.1 - 0.047 13.8 0.5 0.075 13.1 0.5 1.3 1 1 0 1 1 1 0 Helicase HerA, central domain NACHT PF05729.12 KII63425.1 - 0.047 13.6 0.1 0.066 13.1 0.1 1.3 1 0 0 1 1 1 0 NACHT domain Trm56 PF01994.16 KII63425.1 - 0.053 13.4 0.0 0.58 10.1 0.0 2.1 2 0 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 TsaE PF02367.17 KII63425.1 - 0.064 13.3 0.0 0.09 12.8 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KII63425.1 - 0.074 13.2 0.0 0.099 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 KII63425.1 - 0.095 11.8 0.1 0.087 12.0 0.1 1.3 1 1 0 1 1 1 0 G-protein alpha subunit AAA_18 PF13238.6 KII63425.1 - 0.12 13.0 0.8 0.16 12.5 0.8 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KII63425.1 - 0.14 12.5 0.2 0.23 11.7 0.2 1.3 1 1 0 1 1 1 0 AAA domain Glycos_transf_2 PF00535.26 KII63426.1 - 8.8e-05 22.4 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 ASL_C PF08328.11 KII63426.1 - 0.00016 21.7 2.1 0.062 13.4 0.3 2.2 1 1 1 2 2 2 2 Adenylosuccinate lyase C-terminal PPV_E2_C PF00511.17 KII63426.1 - 0.071 13.3 0.3 27 5.0 0.0 3.2 2 2 2 4 4 4 0 E2 (early) protein, C terminal HEPN_Swt1 PF18731.1 KII63426.1 - 0.08 13.3 0.8 12 6.2 0.1 2.2 1 1 1 2 2 2 0 Swt1-like HEPN Zn_peptidase PF04228.13 KII63426.1 - 0.17 11.3 0.3 9.1 5.6 0.1 2.0 1 1 1 2 2 2 0 Putative neutral zinc metallopeptidase Glycos_transf_2 PF00535.26 KII63431.1 - 0.0021 17.9 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 KII63431.1 - 0.0074 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KII63431.1 - 0.081 12.8 0.0 0.32 10.9 0.0 1.9 1 1 0 1 1 1 0 Glycosyltransferase like family 2 KORA PF16509.5 KII63433.1 - 0.068 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor MLVIN_C PF18697.1 KII63435.1 - 0.024 14.7 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain AT_hook PF02178.19 KII63435.1 - 0.98 9.5 7.8 2 8.6 7.8 1.6 1 0 0 1 1 1 0 AT hook motif OAD_gamma PF04277.13 KII63437.1 - 0.063 13.9 0.4 0.12 12.9 0.4 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain GAPT PF11770.8 KII63437.1 - 0.073 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Insulin_TMD PF17870.1 KII63437.1 - 0.43 10.7 2.5 0.5 10.5 1.1 1.8 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment fn3 PF00041.21 KII63438.1 - 1.6e-11 44.4 0.3 3.2e-09 37.0 0.3 2.5 2 1 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KII63438.1 - 0.00054 20.5 0.0 0.0011 19.5 0.0 1.5 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 KII63438.1 - 0.0075 16.4 0.1 0.02 15.0 0.1 1.8 1 1 0 1 1 1 1 Fibronectin type III domain Tissue_fac PF01108.17 KII63438.1 - 0.073 12.9 0.0 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 Tissue factor zf-CCCH PF00642.24 KII63439.1 - 0.00034 20.4 8.4 0.022 14.6 1.3 2.9 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KII63439.1 - 0.00062 20.1 10.6 0.25 11.9 3.2 2.9 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 KII63439.1 - 0.0096 16.1 3.7 0.024 14.8 3.7 1.7 1 0 0 1 1 1 1 Zinc-finger containing family RNase_T PF00929.24 KII63440.1 - 7.1e-11 42.9 0.0 9.6e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 KII63440.1 - 0.16 11.9 0.0 0.21 11.5 0.0 1.4 1 1 0 1 1 1 0 3' exoribonuclease, RNase T-like HSF_DNA-bind PF00447.17 KII63441.1 - 8.7e-23 80.8 1.8 2.7e-21 76.0 0.2 2.7 3 0 0 3 3 3 1 HSF-type DNA-binding DUF496 PF04363.12 KII63441.1 - 0.0092 16.0 0.8 0.022 14.8 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF496) TMF_TATA_bd PF12325.8 KII63441.1 - 0.072 13.3 3.3 0.16 12.2 3.3 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Curto_V3 PF07436.11 KII63441.1 - 0.28 11.6 1.3 0.64 10.4 0.5 2.0 2 0 0 2 2 2 0 Curtovirus V3 protein DUF1664 PF07889.12 KII63441.1 - 1.4 8.9 3.4 11 6.1 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) RT_RNaseH_2 PF17919.1 KII63442.1 - 4e-35 119.8 0.1 8.9e-35 118.7 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63442.1 - 1.6e-24 86.2 0.0 3.5e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII63442.1 - 1.9e-19 70.1 0.0 4.4e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII63442.1 - 3.3e-07 30.8 0.0 7e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII63442.1 - 1.5e-05 25.5 0.0 4e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII63442.1 - 0.0026 18.0 0.1 0.0065 16.8 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII63442.1 - 0.035 13.9 0.0 0.092 12.5 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.6 KII63442.1 - 0.089 12.5 3.7 0.26 11.0 3.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger GCFC PF07842.12 KII63443.1 - 1.7e-35 123.0 5.0 1.7e-35 123.0 5.0 2.0 1 1 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 KII63443.1 - 5.8e-17 61.3 1.0 1.1e-16 60.5 1.0 1.4 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.8 KII63443.1 - 1.5e-08 34.9 1.9 3.3e-08 33.8 1.9 1.6 1 0 0 1 1 1 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 KII63443.1 - 4.9e-06 26.5 0.8 1.3e-05 25.2 0.8 1.7 1 0 0 1 1 1 1 G-patch domain Fzo_mitofusin PF04799.13 KII63443.1 - 0.048 13.2 1.2 0.09 12.3 1.2 1.4 1 0 0 1 1 1 0 fzo-like conserved region YlqD PF11068.8 KII63443.1 - 1.1 9.7 6.7 0.088 13.2 1.5 1.8 2 0 0 2 2 2 0 YlqD protein Ank_2 PF12796.7 KII63444.1 - 2.4e-32 111.3 3.6 4.4e-11 43.2 0.7 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KII63444.1 - 1.9e-30 104.5 1.6 1.5e-12 47.5 0.3 5.2 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KII63444.1 - 5e-30 103.5 10.5 8.6e-10 39.0 0.1 5.5 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 KII63444.1 - 4.2e-26 90.2 10.5 6.1e-06 26.4 0.2 6.8 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 KII63444.1 - 2.8e-24 82.5 6.7 0.00021 21.5 0.0 7.3 7 1 0 7 7 7 6 Ankyrin repeat Ank_2 PF12796.7 KII63445.1 - 2.8e-10 40.7 0.1 0.00012 22.6 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII63445.1 - 7.6e-10 39.1 0.3 0.00045 20.7 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KII63445.1 - 1.2e-07 31.8 1.5 0.0013 19.1 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KII63445.1 - 2.2e-07 31.0 0.2 0.056 13.8 0.0 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII63445.1 - 3.1e-07 30.2 0.7 0.01 16.3 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 KII63446.1 - 4.5e-40 135.5 8.0 1.9e-11 44.3 0.1 6.0 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 KII63446.1 - 4.1e-31 107.4 4.2 2.3e-08 34.5 0.5 4.5 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KII63446.1 - 3.2e-27 91.6 8.7 2.3e-05 24.4 0.0 8.7 8 1 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 KII63446.1 - 1.9e-26 91.7 3.2 6.7e-09 35.8 0.0 5.9 4 2 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 KII63446.1 - 1.2e-25 88.8 1.9 2.4e-08 34.1 0.0 7.4 7 0 0 7 7 7 5 Ankyrin repeat SMC_N PF02463.19 KII63447.1 - 3.6e-24 85.4 14.6 3.6e-23 82.2 14.6 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KII63447.1 - 2.3e-09 37.6 0.3 7.9e-09 35.8 0.0 2.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain SlyX PF04102.12 KII63447.1 - 0.69 10.6 35.3 0.82 10.3 7.2 6.5 5 2 2 7 7 7 0 SlyX DUF4407 PF14362.6 KII63447.1 - 2.1 7.6 36.8 0.56 9.5 9.4 2.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.9 KII63448.1 - 1.8e-05 24.8 14.5 0.00084 19.4 2.0 2.1 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.6 KII63448.1 - 0.0021 17.9 2.8 0.0021 17.9 2.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) GAS PF13851.6 KII63448.1 - 0.0063 15.9 13.3 0.03 13.7 5.3 2.1 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding PUL PF08324.11 KII63448.1 - 0.0076 15.5 0.6 0.0076 15.5 0.6 1.4 2 0 0 2 2 1 1 PUL domain IL17R_D_N PF16742.5 KII63448.1 - 0.013 15.6 0.2 0.019 15.0 0.2 1.3 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D DUF4200 PF13863.6 KII63448.1 - 0.014 15.8 0.4 0.014 15.8 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF4164 PF13747.6 KII63448.1 - 0.019 15.2 6.2 0.047 14.0 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DUF3584 PF12128.8 KII63448.1 - 0.028 12.0 8.2 0.033 11.7 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Tropomyosin PF00261.20 KII63448.1 - 0.028 13.8 11.0 0.17 11.2 2.8 2.1 2 0 0 2 2 2 0 Tropomyosin PRKG1_interact PF15898.5 KII63448.1 - 0.063 14.2 1.5 0.063 14.2 1.5 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain COG2 PF06148.11 KII63448.1 - 0.063 13.4 9.0 0.074 13.1 7.8 1.8 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Rap1_C PF11626.8 KII63448.1 - 0.07 13.2 0.2 0.28 11.3 0.2 1.9 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain FlaC_arch PF05377.11 KII63448.1 - 0.12 12.8 14.8 2.2 8.7 0.5 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) YscO PF07321.12 KII63448.1 - 0.13 12.2 12.1 0.032 14.2 4.3 2.0 1 1 1 2 2 2 0 Type III secretion protein YscO Nas2_N PF18265.1 KII63448.1 - 0.16 11.9 8.0 1.3 9.0 0.2 3.1 3 0 0 3 3 3 0 Nas2 N_terminal domain FUSC PF04632.12 KII63448.1 - 0.18 10.3 0.1 0.2 10.2 0.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family KELK PF15796.5 KII63448.1 - 0.19 12.2 11.4 0.69 10.4 5.5 2.2 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF745 PF05335.13 KII63448.1 - 0.19 11.4 6.8 0.27 10.9 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) FPP PF05911.11 KII63448.1 - 0.2 9.8 17.6 0.47 8.6 17.6 1.5 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF3450 PF11932.8 KII63448.1 - 0.22 10.8 16.6 0.14 11.5 3.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Tup_N PF08581.10 KII63448.1 - 0.29 11.5 10.7 8.3 6.8 2.7 3.1 2 1 1 3 3 3 0 Tup N-terminal Filament PF00038.21 KII63448.1 - 0.38 10.3 14.1 1 8.9 5.9 2.0 1 1 1 2 2 2 0 Intermediate filament protein HOOK PF05622.12 KII63448.1 - 0.43 8.7 16.9 4.9 5.2 17.2 1.9 1 1 0 1 1 1 0 HOOK protein Sec2p PF06428.11 KII63448.1 - 0.5 10.4 16.8 3 7.9 2.1 3.2 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p DUF4763 PF15960.5 KII63448.1 - 0.53 9.5 16.7 1.1 8.5 16.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) Exonuc_VII_L PF02601.15 KII63448.1 - 0.57 9.7 6.5 0.74 9.3 6.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit THOC7 PF05615.13 KII63448.1 - 0.61 10.4 17.0 7.3 6.9 4.5 3.0 2 1 1 3 3 3 0 Tho complex subunit 7 DUF2968 PF11180.8 KII63448.1 - 0.63 9.6 11.0 1.7 8.3 7.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) CENP-H PF05837.12 KII63448.1 - 0.66 10.4 11.5 0.1 13.0 2.3 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Laminin_II PF06009.12 KII63448.1 - 0.68 9.9 12.5 1 9.4 5.5 2.1 1 1 1 2 2 2 0 Laminin Domain II Fez1 PF06818.15 KII63448.1 - 0.87 10.0 14.7 0.046 14.2 5.3 2.0 1 1 0 2 2 2 0 Fez1 LMBR1 PF04791.16 KII63448.1 - 0.97 8.3 4.4 1.2 8.0 4.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF948 PF06103.11 KII63448.1 - 1 9.7 7.0 0.13 12.5 2.2 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ATG16 PF08614.11 KII63448.1 - 1.2 9.3 17.6 3.8e+02 1.2 3.5 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 KII63448.1 - 1.2 7.9 19.2 6.6 5.5 19.2 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 KII63448.1 - 1.7 9.2 18.3 1.1e+02 3.3 18.3 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4407 PF14362.6 KII63448.1 - 1.8 7.9 6.3 2.9 7.2 6.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) CEP63 PF17045.5 KII63448.1 - 2 8.2 18.0 0.039 13.8 7.8 2.0 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa DUF812 PF05667.11 KII63448.1 - 2.5 6.9 19.1 0.34 9.7 5.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Swi5 PF07061.11 KII63448.1 - 2.7 8.1 11.1 3 8.0 4.6 2.7 2 1 1 3 3 3 0 Swi5 Spc24 PF08286.11 KII63448.1 - 2.9 8.2 19.3 3.8 7.8 1.1 3.0 1 1 1 3 3 3 0 Spc24 subunit of Ndc80 KxDL PF10241.9 KII63448.1 - 3 8.2 10.8 0.22 11.8 0.8 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein SKA1 PF07160.12 KII63448.1 - 3.2 7.5 17.0 2 8.2 3.5 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF1664 PF07889.12 KII63448.1 - 3.4 7.7 11.8 0.58 10.2 4.2 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 KII63448.1 - 4.1 7.4 22.2 3.4 7.7 2.4 3.1 2 1 1 3 3 3 0 Prefoldin subunit GvpG PF05120.12 KII63448.1 - 4.1 7.5 9.8 12 6.0 1.9 2.9 2 1 1 3 3 3 0 Gas vesicle protein G PI3K_P85_iSH2 PF16454.5 KII63448.1 - 4.5 6.9 18.9 0.41 10.2 6.2 2.1 1 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CLZ PF16526.5 KII63448.1 - 4.6 7.7 15.4 1.4 9.3 2.6 3.0 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HAUS-augmin3 PF14932.6 KII63448.1 - 5.2 6.6 16.4 0.093 12.3 6.4 2.0 1 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 CENP-Q PF13094.6 KII63448.1 - 5.7 7.1 14.6 7.6 6.7 1.4 3.0 2 1 1 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Snapin_Pallidin PF14712.6 KII63448.1 - 6.4 7.3 16.4 0.93 10.0 8.6 2.5 2 1 0 2 2 2 0 Snapin/Pallidin AAA_13 PF13166.6 KII63448.1 - 6.7 5.2 13.9 51 2.3 4.1 1.9 1 1 0 1 1 1 0 AAA domain Tropomyosin_1 PF12718.7 KII63448.1 - 7.2 6.8 19.3 2.9 8.0 7.8 2.2 1 1 0 1 1 1 0 Tropomyosin like Plasmid_RAQPRD PF09686.10 KII63448.1 - 7.4 6.9 7.5 7.1 6.9 0.5 2.6 2 1 1 3 3 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) DUF4140 PF13600.6 KII63448.1 - 8.2 6.9 10.4 29 5.2 2.1 2.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) FAM76 PF16046.5 KII63448.1 - 8.7 5.6 15.2 46 3.2 15.2 1.8 1 1 0 1 1 1 0 FAM76 protein SMC_N PF02463.19 KII63449.1 - 1.1e-33 116.6 0.6 1.4e-33 116.2 0.6 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KII63449.1 - 1.5e-14 55.0 1.0 1.6e-14 54.9 1.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 KII63449.1 - 1.2e-06 28.6 1.1 1.3e-06 28.4 1.1 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KII63449.1 - 1e-05 25.5 1.2 1.2e-05 25.3 1.2 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KII63449.1 - 4.5e-05 23.1 0.2 0.00011 21.9 0.1 1.8 1 1 0 1 1 1 1 P-loop containing region of AAA domain Folate_rec PF03024.14 KII63455.1 - 5.8e-10 39.3 2.6 6.2e-10 39.2 2.6 1.0 1 0 0 1 1 1 1 Folate receptor family Folate_rec PF03024.14 KII63456.1 - 3.9e-33 114.7 19.1 5.2e-33 114.3 19.1 1.1 1 0 0 1 1 1 1 Folate receptor family SPRY PF00622.28 KII63459.1 - 3.6e-06 27.1 0.4 5.8e-06 26.4 0.4 1.3 1 0 0 1 1 1 1 SPRY domain GAPES1 PF17155.4 KII63459.1 - 0.053 12.8 0.2 0.092 12.0 0.2 1.3 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain zf-NOSIP PF15906.5 KII63460.1 - 1.6e-23 82.7 0.2 2.5e-23 82.0 0.2 1.3 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 KII63460.1 - 0.00051 19.5 15.2 0.034 13.5 7.8 3.1 1 1 2 4 4 4 2 Rtf2 RING-finger Strep_his_triad PF04270.13 KII63460.1 - 0.006 16.6 0.0 0.018 15.0 0.0 1.9 1 0 0 1 1 1 1 Streptococcal histidine triad protein U-box PF04564.15 KII63460.1 - 0.021 15.0 0.0 0.72 10.1 0.0 2.9 3 0 0 3 3 3 0 U-box domain zf-Nse PF11789.8 KII63460.1 - 0.023 14.5 0.6 2.3 8.1 0.0 3.1 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit Dzip-like_N PF13815.6 KII63460.1 - 0.37 10.8 5.7 0.96 9.4 5.8 1.6 1 1 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Pkinase PF00069.25 KII63462.1 - 6.6e-49 166.6 1.0 2.4e-48 164.8 1.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII63462.1 - 3.3e-23 82.3 0.0 1.1e-22 80.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KII63462.1 - 0.00084 18.7 0.0 0.0021 17.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Glyco_transf_64 PF09258.10 KII63462.1 - 0.06 12.6 0.2 0.26 10.6 0.1 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 64 domain APH PF01636.23 KII63462.1 - 0.14 12.1 0.0 0.29 11.0 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family CpxA_peri PF16527.5 KII63462.1 - 0.58 10.5 7.3 0.24 11.8 1.0 2.5 2 0 0 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain eIF2A PF08662.11 KII63464.1 - 0.0046 16.9 0.5 0.41 10.5 0.0 2.7 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A LegC3_N PF18654.1 KII63464.1 - 0.0089 15.3 0.1 0.013 14.8 0.1 1.2 1 0 0 1 1 1 1 LegC3 N-terminal coiled-coil domain RP854 PF17460.2 KII63464.1 - 0.013 15.2 1.1 0.026 14.3 1.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein RP854 DPPIV_N PF00930.21 KII63464.1 - 0.017 13.9 0.2 0.3 9.8 0.1 2.3 1 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region QIL1 PF15884.5 KII63464.1 - 0.13 12.8 2.3 0.66 10.6 0.1 2.3 2 0 0 2 2 2 0 MICOS complex subunit MIC13, QIL1 DUF2532 PF10811.8 KII63465.1 - 0.011 15.7 0.0 0.014 15.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2532) MULE PF10551.9 KII63466.1 - 0.0012 19.2 0.1 0.0024 18.2 0.1 1.6 1 1 0 1 1 1 1 MULE transposase domain DUF3716 PF12511.8 KII63466.1 - 0.085 12.9 0.3 0.085 12.9 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) ODR4-like PF14778.6 KII63468.1 - 6.2e-18 64.9 0.0 4.3e-13 49.0 0.0 2.8 2 1 0 2 2 2 2 Olfactory receptor 4-like Asp PF00026.23 KII63469.1 - 6.5e-39 134.2 0.9 1.4e-38 133.1 0.9 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KII63469.1 - 2e-09 38.0 0.0 0.00091 19.5 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KII63469.1 - 1.6e-08 34.5 0.0 3.2e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal NCU-G1 PF15065.6 KII63470.1 - 3.8e-08 32.7 6.8 1.7e-07 30.6 6.6 2.0 1 1 1 2 2 2 1 Lysosomal transcription factor, NCU-G1 Glycophorin_A PF01102.18 KII63470.1 - 0.32 11.2 1.2 0.7 10.1 1.2 1.5 1 0 0 1 1 1 0 Glycophorin A HEAT PF02985.22 KII63471.1 - 5.6e-06 26.2 3.2 0.005 17.0 0.0 4.2 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 KII63471.1 - 1.2e-05 25.4 3.2 0.00018 21.6 0.1 2.9 2 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KII63471.1 - 0.00072 19.9 0.1 2.4 8.6 0.0 3.1 3 0 0 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 KII63471.1 - 0.0027 18.3 4.4 0.54 10.9 0.0 3.7 3 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region IFRD PF05004.13 KII63471.1 - 0.0093 15.1 0.7 2.3 7.3 0.0 2.5 2 1 0 2 2 2 2 Interferon-related developmental regulator (IFRD) V-ATPase_H_C PF11698.8 KII63471.1 - 0.012 15.7 0.2 0.38 10.9 0.2 2.8 3 0 0 3 3 3 0 V-ATPase subunit H HEAT_EZ PF13513.6 KII63471.1 - 0.13 12.8 0.3 2.6 8.6 0.0 3.1 4 0 0 4 4 4 0 HEAT-like repeat ER_lumen_recept PF00810.18 KII63476.1 - 7.6e-47 159.8 11.0 1.3e-46 159.1 11.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor DDE_3 PF13358.6 KII63476.1 - 0.0015 18.3 0.0 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease PQ-loop PF04193.14 KII63476.1 - 0.094 12.5 0.2 0.094 12.5 0.2 3.4 4 0 0 4 4 4 0 PQ loop repeat Sugar_tr PF00083.24 KII63477.1 - 9.2e-46 156.6 34.5 2.1e-45 155.4 34.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII63477.1 - 9.3e-07 28.1 21.3 9.3e-07 28.1 21.3 3.2 2 1 1 3 3 3 2 Major Facilitator Superfamily Ski_Sno PF02437.17 KII63481.1 - 0.042 13.6 0.1 0.082 12.7 0.0 1.5 2 0 0 2 2 2 0 SKI/SNO/DAC family Ribosomal_S2 PF00318.20 KII63482.1 - 3.4e-28 98.4 3.9 6.2e-14 51.8 0.7 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Guanylate_cyc PF00211.20 KII63483.1 - 0.12 12.0 0.3 0.2 11.3 0.0 1.4 2 0 0 2 2 2 0 Adenylate and Guanylate cyclase catalytic domain Sugar_tr PF00083.24 KII63485.1 - 4.9e-10 38.9 3.2 5.3e-10 38.7 3.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII63485.1 - 0.00014 20.9 2.9 0.00018 20.6 2.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KII63486.1 - 1.5e-32 113.1 17.8 1.6e-32 113.0 17.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII63486.1 - 1.1e-07 31.1 19.9 1.1e-07 31.1 19.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MerC PF03203.14 KII63486.1 - 0.66 10.4 10.6 0.48 10.9 5.8 2.3 2 0 0 2 2 2 0 MerC mercury resistance protein LSM PF01423.22 KII63487.1 - 1.9e-19 69.1 0.1 2.4e-19 68.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain 3H PF02829.14 KII63488.1 - 0.2 12.0 0.0 0.36 11.2 0.0 1.4 1 0 0 1 1 1 0 3H domain DUF4188 PF13826.6 KII63489.1 - 0.088 13.2 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4188) DDE_3 PF13358.6 KII63490.1 - 3e-25 88.7 0.0 3.9e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Syntaphilin PF15290.6 KII63491.1 - 0.0027 17.4 0.1 0.0063 16.2 0.1 1.5 1 0 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp DUF5123 PF17161.4 KII63493.1 - 0.16 13.0 1.2 0.27 12.3 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5123) Exo_endo_phos_2 PF14529.6 KII63494.1 - 1.6e-06 28.0 2.8 1.6e-06 28.0 0.9 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Ribosomal_S17_N PF16205.5 KII63495.1 - 1.3e-29 102.3 0.9 1.3e-29 102.3 0.9 2.0 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 KII63495.1 - 9.9e-26 89.6 2.8 2.2e-25 88.6 2.8 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 AFP_2 PF18815.1 KII63495.1 - 0.17 12.1 0.0 0.33 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial antifreeze protein repeat Telomere_reg-2 PF10193.9 KII63496.1 - 3e-06 27.6 0.3 1.1e-05 25.9 0.2 2.0 1 1 0 1 1 1 1 Telomere length regulation protein DUF5365 PF17326.2 KII63496.1 - 0.0077 16.6 0.4 0.019 15.3 0.4 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5365) Aminotran_1_2 PF00155.21 KII63497.1 - 5.6e-70 236.3 0.0 6.4e-70 236.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KII63497.1 - 8.7e-06 24.5 0.0 1.3e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KII63497.1 - 9.4e-06 24.8 0.0 2.8e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KII63497.1 - 1.1e-05 24.8 0.0 1.7e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase UQ_con PF00179.26 KII63498.1 - 4.1e-26 91.3 1.4 5.2e-26 91.0 1.4 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Transket_pyr PF02779.24 KII63499.1 - 6.2e-60 201.9 0.0 1e-59 201.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 KII63499.1 - 1.8e-58 197.9 0.0 3.5e-58 196.9 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 KII63499.1 - 3.3e-49 166.5 0.0 6.8e-49 165.5 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KII63499.1 - 1.6e-16 59.6 0.2 1.6e-16 59.6 0.2 2.0 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus Cullin PF00888.22 KII63501.1 - 1.4e-13 50.4 1.2 1.7e-13 50.1 1.2 1.1 1 0 0 1 1 1 1 Cullin family HTH_Mga PF08280.11 KII63501.1 - 0.035 14.1 0.0 0.11 12.6 0.0 1.9 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain Nop PF01798.18 KII63504.1 - 9.9e-82 273.8 0.1 9.9e-82 273.8 0.1 1.4 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin ETRAMP PF09716.10 KII63504.1 - 1.7 8.8 4.6 2.6 8.2 4.6 1.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TatD_DNase PF01026.21 KII63505.1 - 4.6e-48 163.8 0.0 5.3e-48 163.6 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Toprim PF01751.22 KII63505.1 - 0.093 13.0 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Toprim domain Ycf15 PF10705.9 KII63507.1 - 0.01 16.0 0.2 0.014 15.6 0.2 1.2 1 0 0 1 1 1 0 Chloroplast protein precursor Ycf15 putative AdoMetDC_leader PF08132.11 KII63507.1 - 0.025 14.5 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide Ldh_1_N PF00056.23 KII63508.1 - 3.1e-27 95.4 0.0 4e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 KII63508.1 - 0.0056 16.6 0.0 0.0098 15.8 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Asp_protease_2 PF13650.6 KII63510.1 - 0.00046 20.8 0.0 0.00088 19.9 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII63510.1 - 0.00057 20.4 0.1 0.0024 18.4 0.1 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII63510.1 - 0.0013 18.7 0.7 0.0027 17.7 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle QLQ PF08880.11 KII63510.1 - 0.16 11.8 0.2 0.29 10.9 0.2 1.5 1 0 0 1 1 1 0 QLQ RT_RNaseH_2 PF17919.1 KII63511.1 - 3.1e-36 123.4 0.0 6.9e-36 122.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63511.1 - 2e-32 111.6 0.0 4.8e-32 110.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII63511.1 - 4.3e-22 78.7 0.0 7.7e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII63512.1 - 6.1e-20 71.1 0.1 1.4e-19 69.9 0.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII63512.1 - 1.5e-17 63.9 0.0 3.2e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII63512.1 - 0.024 14.4 0.1 0.067 13.0 0.0 1.8 1 1 0 1 1 1 0 Integrase core domain Transglut_core PF01841.19 KII63514.1 - 9.8e-05 22.8 0.0 0.00011 22.7 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF3043 PF11241.8 KII63516.1 - 0.28 11.2 1.0 0.62 10.1 0.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) RRM_occluded PF16842.5 KII63517.1 - 0.17 11.8 0.2 0.38 10.7 0.2 1.7 1 1 0 1 1 1 0 Occluded RNA-recognition motif CMV_1a PF12467.8 KII63518.1 - 0.11 12.8 0.2 0.27 11.6 0.1 1.6 1 1 1 2 2 2 0 Cucumber mosaic virus 1a protein family SeqA_N PF17206.3 KII63518.1 - 0.26 10.6 4.5 8.3 5.8 0.1 3.1 3 0 0 3 3 3 0 SeqA protein N-terminal domain Transglut_core PF01841.19 KII63519.1 - 2.7e-05 24.6 0.0 5.3e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Serpin PF00079.20 KII63521.1 - 1.2e-17 64.3 1.2 1.3e-17 64.2 1.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII63524.1 - 1e-41 143.5 4.3 2.6e-41 142.2 4.3 1.6 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4746 PF15928.5 KII63524.1 - 0.011 15.2 0.4 0.016 14.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RPN2_C PF18004.1 KII63524.1 - 0.39 10.6 6.0 1.7 8.5 4.6 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nop14 PF04147.12 KII63524.1 - 0.57 8.3 9.9 0.77 7.9 9.9 1.1 1 0 0 1 1 1 0 Nop14-like family rve PF00665.26 KII63528.1 - 1.8e-24 86.2 0.0 2.8e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63528.1 - 4.8e-12 45.8 0.8 1.9e-11 43.9 0.3 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain MLVIN_C PF18697.1 KII63528.1 - 0.00019 21.5 0.0 0.00039 20.5 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII63528.1 - 0.00066 19.4 0.0 0.0018 18.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII63528.1 - 0.073 13.3 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 H2C2 zinc finger Thioredoxin_13 PF18401.1 KII63529.1 - 0.14 12.1 1.8 0.75 9.7 0.3 2.5 2 1 1 3 3 3 0 Thioredoxin-like domain DDE_Tnp_IS1595 PF12762.7 KII63530.1 - 4.1e-10 39.9 0.0 6.4e-10 39.2 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII63531.1 - 6.4e-11 42.2 0.4 5.1e-06 26.3 0.1 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease Init_tRNA_PT PF04179.12 KII63531.1 - 0.056 13.7 0.0 0.094 13.0 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain DUF1627 PF07789.12 KII63531.1 - 0.098 12.3 0.3 0.15 11.7 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1627) DDE_3 PF13358.6 KII63532.1 - 4.7e-05 23.2 0.0 7.8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH_2 PF17919.1 KII63534.1 - 1.5e-12 47.4 0.0 3.1e-12 46.4 0.0 1.4 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63534.1 - 4.5e-06 26.9 0.0 6.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase FAM196 PF15265.6 KII63535.1 - 0.018 14.5 0.6 0.02 14.4 0.6 1.1 1 0 0 1 1 1 0 FAM196 family AID PF18767.1 KII63536.1 - 0.0013 18.7 0.0 0.56 10.3 0.0 2.4 1 1 1 2 2 2 2 Activation induced deaminase DUF2949 PF11165.8 KII63536.1 - 0.045 14.1 0.0 16 5.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2949) MU2_FHA PF18221.1 KII63536.1 - 0.16 12.0 0.1 24 5.1 0.0 2.3 1 1 0 2 2 2 0 Mutator 2 Fork head associated domain RT_RNaseH_2 PF17919.1 KII63537.1 - 6.1e-05 23.0 0.3 0.036 14.1 0.3 2.8 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63537.1 - 0.00063 20.0 0.0 0.0012 19.1 0.0 1.5 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Sortilin-Vps10 PF15902.5 KII63538.1 - 7e-14 51.5 0.4 1.7e-13 50.2 0.4 1.6 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII63538.1 - 1.8e-08 34.9 1.7 1.8e-08 34.9 1.7 1.9 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII63538.1 - 0.00012 21.5 0.7 0.3 11.2 0.0 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat zf-RING-like PF08746.11 KII63538.1 - 0.21 11.9 1.7 0.98 9.8 0.2 2.4 2 0 0 2 2 2 0 RING-like domain Sortilin_C PF15901.5 KII63539.1 - 1.2e-10 42.0 2.4 1.2e-10 42.0 2.4 1.6 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII63539.1 - 0.00055 18.8 2.5 0.00086 18.2 2.0 1.6 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII63539.1 - 0.016 15.1 6.8 0.26 11.4 0.0 3.3 2 0 0 2 2 2 0 BNR/Asp-box repeat DDE_3 PF13358.6 KII63541.1 - 0.06 13.1 0.0 0.29 10.9 0.0 1.9 1 1 1 2 2 2 0 DDE superfamily endonuclease Sortilin_C PF15901.5 KII63543.1 - 1.5e-09 38.4 0.7 1.5e-09 38.4 0.7 1.6 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII63543.1 - 4.3e-06 25.8 1.1 0.00022 20.2 0.3 2.7 1 1 1 2 2 2 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII63544.1 - 1.2e-09 38.8 6.6 1.2e-09 38.7 6.6 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII63545.1 - 0.0015 17.4 1.8 0.0055 15.5 1.5 1.7 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, UCR_UQCRX_QCR9 PF05365.12 KII63545.1 - 0.024 14.6 1.4 3.9 7.5 1.2 2.6 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like DUF960 PF06124.11 KII63545.1 - 0.032 14.9 0.2 0.083 13.5 0.0 1.7 2 0 0 2 2 2 0 Staphylococcal protein of unknown function (DUF960) DUF2582 PF10771.9 KII63545.1 - 0.033 14.3 0.2 1.7 8.9 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix domain (DUF2582) BNR PF02012.20 KII63545.1 - 5.3 7.5 9.8 3.2 8.1 0.7 3.8 5 0 0 5 5 5 0 BNR/Asp-box repeat Sortilin_C PF15901.5 KII63546.1 - 1.9e-08 34.8 0.1 2.8e-08 34.3 0.1 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal DUF5106 PF17127.4 KII63548.1 - 0.096 13.0 1.0 0.37 11.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5106) Sortilin-Vps10 PF15902.5 KII63549.1 - 0.00048 19.0 0.3 0.0034 16.2 0.3 1.9 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII63549.1 - 5.3 7.5 0.0 5.3 7.5 0.0 4.1 5 0 0 5 5 5 0 BNR/Asp-box repeat Sortilin_C PF15901.5 KII63550.1 - 4.2e-11 43.5 2.4 4.2e-11 43.5 2.4 1.9 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII63550.1 - 0.7 10.1 4.1 22 5.6 1.1 3.3 3 0 0 3 3 3 0 BNR/Asp-box repeat zf-RING-like PF08746.11 KII63550.1 - 3.7 7.9 0.0 3.7 7.9 0.0 3.5 4 0 0 4 4 4 0 RING-like domain BNR PF02012.20 KII63551.1 - 3.7e-06 26.1 3.1 0.053 13.5 0.2 4.5 3 0 0 3 3 3 2 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII63551.1 - 2.9e-05 23.1 2.3 3.6e-05 22.8 0.7 2.0 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII63552.1 - 4e-14 53.3 5.0 4e-14 53.3 5.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Ldl_recept_a PF00057.18 KII63553.1 - 4.2e-08 33.3 18.4 7.5e-08 32.5 13.4 2.5 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A Defensin_beta PF00711.19 KII63553.1 - 0.14 12.2 8.3 0.36 10.9 8.3 1.7 1 0 0 1 1 1 0 Beta defensin RVT_1 PF00078.27 KII63557.1 - 0.012 15.2 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Terminase_3C PF17288.2 KII63558.1 - 0.11 12.8 0.3 0.28 11.5 0.0 1.7 2 0 0 2 2 2 0 Terminase RNAseH like domain Sortilin_C PF15901.5 KII63559.1 - 1.9e-12 47.9 0.5 2.8e-12 47.3 0.5 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII63559.1 - 1.6e-08 33.8 0.6 1.6e-08 33.8 0.6 1.8 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII63559.1 - 8.8e-05 22.0 0.2 0.18 11.9 0.0 3.9 2 0 0 2 2 2 2 BNR/Asp-box repeat Ldl_recept_a PF00057.18 KII63561.1 - 6.4e-08 32.7 8.8 6.4e-08 32.7 8.8 3.0 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A HypF_C PF17788.1 KII63561.1 - 0.06 14.0 0.1 0.31 11.8 0.0 2.0 1 1 2 3 3 3 0 HypF Kae1-like domain Sortilin_C PF15901.5 KII63565.1 - 2.6e-12 47.4 3.0 2.6e-12 47.4 3.0 1.7 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII63565.1 - 1e-07 31.2 0.1 3.5e-06 26.1 0.0 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII63565.1 - 0.00016 21.8 13.7 0.00016 21.8 13.7 3.0 2 1 1 3 3 3 1 Low-density lipoprotein receptor domain class A BNR PF02012.20 KII63565.1 - 0.053 13.5 8.2 6.7 7.2 0.4 4.2 3 0 0 3 3 3 0 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII63566.1 - 1.5e-05 24.0 0.0 0.0002 20.3 0.0 2.0 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII63566.1 - 0.074 13.1 2.2 1.9 8.8 0.2 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat CHB_HEX_C PF03174.13 KII63566.1 - 0.18 11.8 0.1 2.2 8.3 0.0 2.5 2 1 1 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain SLATT_4 PF18186.1 KII63567.1 - 0.046 13.4 0.0 0.06 13.0 0.0 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 Sortilin-Vps10 PF15902.5 KII63568.1 - 1.1e-06 27.7 0.3 1.7e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII63568.1 - 0.0015 18.7 1.2 0.0022 18.2 1.2 1.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A BNR PF02012.20 KII63568.1 - 0.71 10.1 9.2 7 7.1 0.2 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat Gal-3-0_sulfotr PF06990.11 KII63570.1 - 2.7e-24 85.8 0.5 2.2e-23 82.8 0.5 1.9 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase YmgB PF10798.8 KII63570.1 - 0.027 14.3 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR Ribosomal_L14 PF00238.19 KII63571.1 - 0.03 14.4 0.2 0.057 13.5 0.2 1.4 1 0 0 1 1 1 0 Ribosomal protein L14p/L23e Fcf1 PF04900.12 KII63571.1 - 1.3 9.4 5.4 0.8 10.1 0.8 2.5 1 1 1 2 2 2 0 Fcf1 DDE_Tnp_IS1595 PF12762.7 KII63572.1 - 3e-15 56.5 0.0 4.5e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Thioredoxin PF00085.20 KII63573.1 - 1.1e-31 108.8 0.0 5.8e-26 90.5 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin OST3_OST6 PF04756.13 KII63573.1 - 1.5e-06 27.8 1.0 4e-06 26.4 0.2 2.0 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KII63573.1 - 5.8e-06 26.7 0.2 9.6e-05 22.8 0.1 2.8 3 1 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KII63573.1 - 5.9e-05 23.3 0.8 4.7 7.6 0.0 4.3 3 2 0 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.6 KII63573.1 - 0.0072 16.5 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 KII63574.1 - 2.4e-33 114.2 0.0 4.3e-30 103.7 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 KII63574.1 - 5.7e-06 26.7 0.0 2e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_6 PF13848.6 KII63574.1 - 2.6e-05 24.2 0.0 0.00057 19.8 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 KII63574.1 - 0.00015 21.2 0.0 0.00022 20.7 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 KII63574.1 - 0.0018 18.4 0.0 0.0041 17.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 KII63574.1 - 0.0044 16.9 0.0 0.0083 16.0 0.0 1.4 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 KII63574.1 - 0.017 15.4 0.0 0.42 11.0 0.0 2.9 3 1 1 4 4 4 0 Thioredoxin-like DUF4371 PF14291.6 KII63575.1 - 2.7e-12 46.9 0.1 2.7e-12 46.9 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 KII63575.1 - 2.4e-06 27.3 0.1 5.7e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ldh_1_C PF02866.18 KII63576.1 - 2.5e-32 112.1 0.0 3.8e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KII63576.1 - 1e-07 32.1 0.3 3e-07 30.6 0.1 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain DDE_3 PF13358.6 KII63577.1 - 1.3e-08 34.7 0.2 1.6e-08 34.5 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII63577.1 - 0.097 12.9 0.0 0.2 11.9 0.0 1.6 1 1 0 1 1 1 0 Integrase core domain Ldh_1_C PF02866.18 KII63578.1 - 3.7e-32 111.6 0.0 4.3e-32 111.4 0.0 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain DDE_Tnp_IS1595 PF12762.7 KII63579.1 - 8.9e-11 42.0 0.0 2.3e-10 40.7 0.0 1.8 2 1 0 2 2 2 1 ISXO2-like transposase domain Thioredoxin PF00085.20 KII63580.1 - 1e-27 96.1 0.3 5.2e-25 87.4 0.1 3.1 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_6 PF13848.6 KII63580.1 - 2.1e-08 34.3 3.3 0.00061 19.7 0.1 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KII63580.1 - 1.2e-06 28.7 1.8 0.084 13.2 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 KII63580.1 - 1.2e-06 28.9 2.1 4.5e-05 23.8 0.4 3.2 3 1 0 3 3 3 1 Thioredoxin-like domain OST3_OST6 PF04756.13 KII63580.1 - 0.00012 21.5 0.4 0.0012 18.3 0.0 2.2 1 1 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 KII63580.1 - 0.00023 21.1 0.0 0.0015 18.5 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin domain DUF953 PF06110.11 KII63580.1 - 0.0097 15.5 0.1 0.088 12.4 0.1 2.2 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_7 PF13899.6 KII63580.1 - 0.017 15.3 0.0 0.042 14.0 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like TraF PF13728.6 KII63580.1 - 0.031 14.1 0.0 0.79 9.5 0.0 2.4 2 0 0 2 2 2 0 F plasmid transfer operon protein Gal-3-0_sulfotr PF06990.11 KII63581.1 - 2.6e-29 102.3 3.9 1.1e-28 100.2 3.9 1.8 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase rve PF00665.26 KII63584.1 - 8e-25 87.4 0.0 1.5e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII63584.1 - 0.0017 18.6 0.4 0.0078 16.4 0.0 2.0 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.6 KII63584.1 - 0.0043 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63584.1 - 0.044 13.9 3.5 0.051 13.7 0.8 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain MLVIN_C PF18697.1 KII63584.1 - 0.048 13.8 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Sortilin-Vps10 PF15902.5 KII63587.1 - 2.2e-12 46.5 0.8 6.8e-12 44.9 0.1 2.0 1 1 1 2 2 2 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII63587.1 - 4.1e-10 40.3 2.1 5e-10 40.0 1.0 1.6 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII63587.1 - 0.00044 19.8 3.5 1.4 9.3 0.2 4.1 4 0 0 4 4 4 2 BNR/Asp-box repeat DDE_3 PF13358.6 KII63588.1 - 1.4e-08 34.6 0.0 3.7e-08 33.2 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII63588.1 - 3.6e-05 23.3 0.0 5.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 KII63588.1 - 0.067 13.8 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain PhoU PF01895.19 KII63589.1 - 0.061 13.8 0.6 0.12 12.9 0.1 1.7 1 1 1 2 2 2 0 PhoU domain TrmO PF01980.16 KII63589.1 - 0.077 13.2 0.0 0.096 12.9 0.0 1.1 1 0 0 1 1 1 0 tRNA-methyltransferase O DUF953 PF06110.11 KII63590.1 - 0.034 13.8 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Sortilin_C PF15901.5 KII63591.1 - 1.2e-10 42.1 3.0 2.1e-10 41.2 3.0 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII63591.1 - 5.1e-08 32.1 4.5 7.6e-06 25.0 0.5 1.6 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, RT_RNaseH_2 PF17919.1 KII63596.1 - 3.1e-17 62.4 0.1 3.9e-11 42.9 0.0 2.7 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63596.1 - 1.7e-16 60.4 0.0 2.7e-14 53.3 0.0 2.6 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII63596.1 - 2.2e-15 56.8 0.4 1.5e-14 54.0 0.1 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII63596.1 - 0.00028 20.9 1.1 0.001 19.1 0.0 2.5 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII63596.1 - 0.0018 18.5 0.0 0.0038 17.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Nup88 PF10168.9 KII63598.1 - 0.0017 16.3 15.3 0.0018 16.2 15.3 1.0 1 0 0 1 1 1 1 Nuclear pore component KELK PF15796.5 KII63598.1 - 0.0032 17.9 10.1 0.022 15.2 1.2 2.9 2 1 0 3 3 3 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase CALCOCO1 PF07888.11 KII63598.1 - 0.0049 15.8 7.9 0.0063 15.4 7.7 1.3 1 1 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like LMBR1 PF04791.16 KII63598.1 - 0.013 14.4 7.3 0.016 14.2 7.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Laminin_I PF06008.14 KII63598.1 - 0.015 15.0 10.7 0.025 14.3 10.7 1.3 1 1 0 1 1 1 0 Laminin Domain I ABC_tran_CTD PF16326.5 KII63598.1 - 0.019 15.2 5.4 0.53 10.6 0.7 3.1 1 1 2 3 3 3 0 ABC transporter C-terminal domain MAD PF05557.13 KII63598.1 - 0.039 12.3 13.2 0.043 12.2 13.2 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein COG2 PF06148.11 KII63598.1 - 0.04 14.0 4.2 4.1 7.5 0.1 3.0 1 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 APG6_N PF17675.1 KII63598.1 - 0.042 14.4 8.1 0.3 11.6 8.5 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region Cauli_DNA-bind PF03310.13 KII63598.1 - 0.11 12.5 5.9 0.2 11.7 5.9 1.5 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein CENP-H PF05837.12 KII63598.1 - 0.13 12.7 10.3 1.9 8.9 3.6 2.1 1 1 0 2 2 2 0 Centromere protein H (CENP-H) Sec34 PF04136.15 KII63598.1 - 0.14 12.0 11.1 0.33 10.8 1.1 2.3 1 1 1 2 2 2 0 Sec34-like family IFT57 PF10498.9 KII63598.1 - 0.14 11.1 17.4 1.5 7.7 9.2 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Imm3 PF14425.6 KII63598.1 - 0.14 12.2 9.6 1.3 9.0 0.6 2.2 1 1 1 2 2 2 0 Immunity protein Imm3 Baculo_PEP_C PF04513.12 KII63598.1 - 0.15 12.1 7.6 0.16 12.0 5.8 1.8 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Dynactin_p22 PF07426.11 KII63598.1 - 0.16 11.8 12.8 0.25 11.2 12.8 1.2 1 0 0 1 1 1 0 Dynactin subunit p22 Jnk-SapK_ap_N PF09744.9 KII63598.1 - 0.18 12.1 8.8 6.7 6.9 8.9 2.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Nup54 PF13874.6 KII63598.1 - 0.2 11.8 3.7 0.47 10.6 1.1 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 ZapA PF05164.13 KII63598.1 - 0.28 11.6 4.4 1.3 9.5 0.1 2.9 1 1 0 2 2 2 0 Cell division protein ZapA DNA_repr_REX1B PF14966.6 KII63598.1 - 0.34 11.6 5.0 0.66 10.7 0.9 2.4 2 1 0 2 2 2 0 DNA repair REX1-B DUF4600 PF15372.6 KII63598.1 - 0.44 11.0 14.3 0.59 10.6 4.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) BRE1 PF08647.11 KII63598.1 - 0.45 10.6 19.8 0.073 13.1 3.9 3.2 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase Nsp1_C PF05064.13 KII63598.1 - 0.47 10.3 8.6 0.22 11.3 1.7 2.7 1 1 1 2 2 2 0 Nsp1-like C-terminal region Glycoprot_B_PH2 PF17417.2 KII63598.1 - 0.53 10.7 4.0 0.46 10.9 1.9 2.0 2 1 0 2 2 1 0 Herpesvirus Glycoprotein B PH-like domain Tup_N PF08581.10 KII63598.1 - 0.6 10.5 12.6 0.56 10.6 5.2 3.2 2 1 0 2 2 2 0 Tup N-terminal PI_PP_I PF18363.1 KII63598.1 - 0.73 10.1 4.6 9.9 6.4 1.2 2.4 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain DUF1664 PF07889.12 KII63598.1 - 0.85 9.7 11.4 4.3 7.4 7.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) GLTP PF08718.11 KII63598.1 - 0.91 9.8 5.3 1.6 9.0 0.5 2.5 1 1 1 2 2 2 0 Glycolipid transfer protein (GLTP) DASH_Dam1 PF08653.10 KII63598.1 - 1.1 9.1 7.3 7.1 6.5 0.1 3.4 2 1 1 4 4 4 0 DASH complex subunit Dam1 Spc24 PF08286.11 KII63598.1 - 2.1 8.6 12.9 12 6.1 5.6 2.8 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 YtxH PF12732.7 KII63598.1 - 2.7 8.6 7.1 18 6.0 0.5 2.6 2 1 0 2 2 2 0 YtxH-like protein NPV_P10 PF05531.12 KII63598.1 - 3.8 8.0 9.9 4.7 7.7 2.8 2.9 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein FAM76 PF16046.5 KII63598.1 - 4.3 6.6 12.6 5.2 6.3 12.6 1.2 1 0 0 1 1 1 0 FAM76 protein DUF724 PF05266.14 KII63598.1 - 4.4 7.1 14.7 11 5.8 11.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF2203 PF09969.9 KII63598.1 - 5.1 7.9 7.9 2.9 8.6 1.7 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Viral_Beta_CD PF04530.12 KII63604.1 - 0.078 13.3 0.1 0.096 13.0 0.1 1.1 1 0 0 1 1 1 0 Viral Beta C/D like family Archease PF01951.16 KII63605.1 - 2.2e-44 151.0 0.7 2.5e-44 150.8 0.7 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) DUF4370 PF14290.6 KII63605.1 - 0.0025 17.7 0.4 0.0042 17.0 0.3 1.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4370) Prenyltransf PF01255.19 KII63606.1 - 4.6e-38 131.0 0.1 5.2e-38 130.8 0.1 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DDE_Tnp_IS1595 PF12762.7 KII63607.1 - 7.5e-08 32.5 0.0 1.6e-07 31.4 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain AhpC-TSA_2 PF13911.6 KII63608.1 - 0.0016 18.5 0.0 0.0024 18.0 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme VPS53_C PF16854.5 KII63611.1 - 0.019 14.9 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus DUF913 PF06025.12 KII63611.1 - 0.064 12.2 0.0 0.09 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PspB PF06667.12 KII63614.1 - 0.15 12.1 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Phage shock protein B CENP-B_N PF04218.13 KII63617.1 - 0.0002 20.9 0.1 0.00036 20.1 0.1 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 KII63617.1 - 0.0035 17.1 0.1 0.0068 16.2 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 KII63617.1 - 0.01 16.0 0.1 0.022 14.9 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Phage_NinH PF06322.11 KII63617.1 - 0.053 13.4 0.1 0.21 11.5 0.1 2.0 1 1 1 2 2 2 0 Phage NinH protein Glyco_trans_1_3 PF13528.6 KII63617.1 - 0.093 12.0 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 1 HTH_Tnp_ISL3 PF13542.6 KII63617.1 - 0.14 11.6 0.1 0.32 10.4 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 LacI PF00356.21 KII63617.1 - 0.2 11.5 0.0 0.35 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Ig_3 PF13927.6 KII63618.1 - 4.2e-12 46.5 0.1 5.4e-12 46.1 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KII63618.1 - 4.2e-11 42.8 0.0 5.8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KII63618.1 - 8.5e-07 29.2 0.0 1.2e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KII63618.1 - 5.3e-05 23.3 0.0 0.016 15.3 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KII63618.1 - 0.0048 17.1 0.3 0.016 15.4 0.3 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KII63618.1 - 0.028 14.0 0.2 0.16 11.5 0.1 2.2 2 1 0 2 2 2 0 Immunoglobulin domain SNAP PF14938.6 KII63619.1 - 6.8e-18 65.1 5.5 1.1e-17 64.4 5.5 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NADH_4Fe-4S PF10589.9 KII63619.1 - 0.018 15.1 1.1 0.033 14.3 0.4 1.9 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region ATP-grasp_6 PF18419.1 KII63619.1 - 0.022 14.4 0.3 0.077 12.6 0.3 1.9 1 0 0 1 1 1 0 ATP-grasp-like domain TPR_6 PF13174.6 KII63619.1 - 0.074 13.7 0.6 3.1 8.6 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat SBP_bac_5 PF00496.22 KII63619.1 - 0.079 11.9 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle TPR_8 PF13181.6 KII63619.1 - 0.15 12.4 7.6 3.1 8.2 0.8 4.0 3 1 2 5 5 5 0 Tetratricopeptide repeat AcylCoA_dehyd_C PF12186.8 KII63619.1 - 1 9.5 5.1 8.3 6.6 0.2 3.3 3 1 1 4 4 4 0 Acyl-CoA dehydrogenase C terminal DUF4473 PF14747.6 KII63619.1 - 1.8 9.2 6.4 3.2 8.4 0.4 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4473) DUF2600 PF10776.9 KII63620.1 - 0.13 11.1 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) Transglut_N PF00868.20 KII63621.1 - 2.1e-06 28.1 0.0 3.1e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.19 KII63622.1 - 6e-06 26.7 0.0 7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_C PF00927.22 KII63623.1 - 0.076 13.2 0.2 5.5 7.2 0.1 2.6 2 0 0 2 2 2 0 Transglutaminase family, C-terminal ig like domain Collagen PF01391.18 KII63628.1 - 0.012 15.3 4.5 0.026 14.3 4.5 1.6 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Pericardin_rpt PF07054.11 KII63628.1 - 0.054 13.6 20.7 0.054 13.6 20.7 4.3 1 1 4 5 5 5 0 Pericardin like repeat Annexin PF00191.20 KII63629.1 - 0.00012 22.0 0.1 0.001 19.1 0.0 2.1 2 0 0 2 2 2 1 Annexin Ins_P5_2-kin PF06090.12 KII63631.1 - 0.25 10.7 3.0 1 8.8 0.3 2.4 3 0 0 3 3 3 0 Inositol-pentakisphosphate 2-kinase DDE_3 PF13358.6 KII63635.1 - 0.0019 18.0 0.1 0.0027 17.5 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DAO PF01266.24 KII63637.1 - 4.8e-15 56.0 0.1 4.9e-15 56.0 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 KII63637.1 - 0.0037 16.4 0.1 0.0042 16.2 0.1 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 KII63637.1 - 0.0073 15.6 0.0 0.0086 15.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KII63637.1 - 0.0084 16.6 1.6 0.013 16.0 0.9 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KII63637.1 - 0.011 15.9 0.2 0.018 15.3 0.2 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KII63637.1 - 0.025 13.9 0.4 0.041 13.1 0.4 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KII63637.1 - 0.044 12.8 0.1 0.049 12.7 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 KII63637.1 - 0.054 12.6 0.1 0.054 12.6 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 KII63637.1 - 0.11 11.7 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 KII63637.1 - 0.15 11.4 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase DAO PF01266.24 KII63638.1 - 2.1e-10 40.7 0.0 2.4e-10 40.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase CHU_C PF13585.6 KII63638.1 - 0.072 13.2 0.3 0.28 11.3 0.1 1.7 1 1 1 2 2 2 0 C-terminal domain of CHU protein family DAO_C PF16901.5 KII63639.1 - 1.1e-26 93.2 0.0 1.2e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase DUF1221 PF06760.11 KII63640.1 - 0.015 14.8 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1221) TssO PF17561.2 KII63640.1 - 0.016 15.3 0.4 0.018 15.1 0.4 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssO DBB PF14545.6 KII63640.1 - 0.018 15.0 0.6 0.16 11.9 0.1 1.9 1 1 1 2 2 2 0 Dof, BCAP, and BANK (DBB) motif, Syntaxin-6_N PF09177.11 KII63640.1 - 0.019 15.5 0.1 0.023 15.3 0.1 1.2 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF241 PF03087.14 KII63640.1 - 0.027 14.3 0.2 0.033 14.0 0.2 1.2 1 0 0 1 1 1 0 Arabidopsis protein of unknown function GlnE PF03710.15 KII63640.1 - 0.053 12.9 0.4 0.06 12.7 0.4 1.0 1 0 0 1 1 1 0 Glutamate-ammonia ligase adenylyltransferase CHDCT2 PF08074.11 KII63640.1 - 0.056 13.6 0.5 0.13 12.4 0.1 1.6 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain Prefoldin_2 PF01920.20 KII63640.1 - 0.056 13.4 1.4 0.1 12.6 1.4 1.3 1 0 0 1 1 1 0 Prefoldin subunit HTH_48 PF17906.1 KII63642.1 - 1.6e-05 24.9 1.1 2.6e-05 24.3 1.1 1.4 1 0 0 1 1 1 1 HTH domain in Mos1 transposase Dynamin_M PF01031.20 KII63644.1 - 8.2e-58 195.9 4.9 8.1e-55 186.0 4.1 3.0 2 1 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 KII63644.1 - 1e-41 142.8 0.1 1.7e-41 142.1 0.1 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KII63644.1 - 4.6e-05 23.5 0.1 0.00012 22.2 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 KII63644.1 - 0.098 12.0 0.6 1.4 8.2 0.0 2.3 2 0 0 2 2 2 0 AIG1 family TFIIF_alpha PF05793.12 KII63645.1 - 2e-12 46.5 26.2 3.9e-05 22.4 0.5 3.3 2 1 1 3 3 3 3 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sec2p PF06428.11 KII63645.1 - 1.8 8.6 6.3 0.21 11.6 0.5 2.4 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Methyltr_RsmB-F PF01189.17 KII63647.1 - 2.1e-19 70.0 0.1 3.6e-19 69.2 0.1 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 KII63647.1 - 0.00036 21.2 0.0 0.00088 19.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KII63647.1 - 0.0012 19.0 0.0 0.0018 18.4 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 KII63647.1 - 0.0092 15.8 0.0 0.021 14.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KII63647.1 - 0.04 13.2 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family RT_RNaseH_2 PF17919.1 KII63648.1 - 5.7e-36 122.6 0.1 1.5e-35 121.2 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63648.1 - 9.8e-35 119.0 0.1 2.2e-34 117.9 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII63648.1 - 1.2e-26 93.6 0.2 2.3e-26 92.7 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII63648.1 - 4e-24 85.1 0.0 1.3e-23 83.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63648.1 - 8.8e-19 67.4 0.9 1.9e-18 66.3 0.1 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII63648.1 - 6.4e-06 26.3 0.1 0.0007 19.8 0.0 2.7 2 0 0 2 2 2 1 H2C2 zinc finger zf-CCHC PF00098.23 KII63648.1 - 1.7e-05 24.7 10.7 4.1e-05 23.5 1.8 2.6 2 0 0 2 2 2 1 Zinc knuckle rve_3 PF13683.6 KII63648.1 - 0.016 15.0 0.0 0.05 13.4 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII63648.1 - 0.027 14.7 0.7 0.057 13.6 0.0 1.9 2 0 0 2 2 2 0 DDE domain RVP_2 PF08284.11 KII63648.1 - 0.034 13.9 0.4 0.1 12.4 0.1 1.9 2 0 0 2 2 2 0 Retroviral aspartyl protease Tape_meas_lam_C PF09718.10 KII63648.1 - 0.05 13.7 0.0 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) gag-asp_proteas PF13975.6 KII63648.1 - 0.056 14.0 0.1 0.13 12.8 0.1 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.6 KII63648.1 - 0.36 10.6 7.1 4.7 7.0 0.5 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 KII63648.1 - 5.4 6.9 11.1 7.8 6.4 0.7 2.8 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.6 KII63649.1 - 1.6e-10 40.9 0.0 1.9e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII63650.1 - 1.6e-05 24.5 0.0 0.00015 21.4 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain TrmB PF01978.19 KII63650.1 - 3.9e-05 23.4 0.1 0.0001 22.1 0.0 1.7 2 0 0 2 2 1 1 Sugar-specific transcriptional regulator TrmB PAX PF00292.18 KII63650.1 - 5.6e-05 23.1 0.1 8e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain CENP-B_N PF04218.13 KII63650.1 - 0.00022 20.8 0.0 0.00058 19.4 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.6 KII63650.1 - 0.00029 20.3 1.5 0.0035 16.9 0.1 2.4 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_32 PF13565.6 KII63650.1 - 0.00041 20.9 0.1 0.0021 18.6 0.0 2.0 1 1 1 2 2 2 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 KII63650.1 - 0.00067 19.0 0.1 0.0027 17.1 0.0 2.1 3 1 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 Fe_dep_repress PF01325.19 KII63650.1 - 0.0016 18.6 0.0 0.003 17.7 0.0 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_Tnp_Tc3_2 PF01498.18 KII63650.1 - 0.0019 18.4 0.2 0.01 16.0 0.0 2.0 2 0 0 2 2 2 1 Transposase MarR_2 PF12802.7 KII63650.1 - 0.0026 17.6 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_29 PF13551.6 KII63650.1 - 0.0073 16.3 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix Sigma70_r4 PF04545.16 KII63650.1 - 0.017 14.6 0.0 0.041 13.4 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 B5 PF03484.15 KII63650.1 - 0.02 15.2 0.0 0.042 14.1 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetase B5 domain HTH_40 PF14493.6 KII63650.1 - 0.024 15.1 0.3 0.044 14.2 0.3 1.4 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_28 PF13518.6 KII63650.1 - 0.024 14.7 0.0 0.14 12.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII63650.1 - 0.038 13.7 0.0 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 Phage_CI_repr PF07022.13 KII63650.1 - 0.04 14.0 0.0 0.053 13.6 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain HTH_38 PF13936.6 KII63650.1 - 0.043 13.6 0.0 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_IclR PF09339.10 KII63650.1 - 0.047 13.5 0.0 0.45 10.4 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain DNA_pol3_alpha PF07733.12 KII63650.1 - 0.047 13.3 0.0 0.054 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha NTPase domain HTH_33 PF13592.6 KII63650.1 - 0.048 13.3 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix TnsD PF15978.5 KII63650.1 - 0.061 12.3 0.4 0.12 11.3 0.4 1.4 1 1 1 2 2 2 0 Tn7-like transposition protein D HTH_27 PF13463.6 KII63650.1 - 0.087 13.3 0.0 0.21 12.1 0.0 1.7 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF4423 PF14394.6 KII63650.1 - 0.096 12.4 0.1 0.24 11.1 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4423) HTH_30 PF13556.6 KII63650.1 - 0.13 12.1 0.1 1.6 8.6 0.0 2.5 2 1 1 3 3 3 0 PucR C-terminal helix-turn-helix domain MFS_1 PF07690.16 KII63651.1 - 8.2e-22 77.6 30.3 1.3e-12 47.3 14.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KII63651.1 - 0.00024 20.1 15.0 0.0037 16.2 0.2 3.0 1 1 2 4 4 4 2 MFS_1 like family Sugar_tr PF00083.24 KII63651.1 - 0.00092 18.2 7.0 0.00092 18.2 7.0 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 KII63651.1 - 0.0015 17.0 0.6 0.0015 17.0 0.6 1.7 2 0 0 2 2 2 1 Transmembrane secretion effector ChaC PF04752.12 KII63653.1 - 8.9e-55 185.5 0.0 1e-54 185.3 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein cwf18 PF08315.12 KII63656.1 - 1e-18 68.3 1.3 1.2e-18 68.1 1.3 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor MRP-L27 PF09809.9 KII63656.1 - 0.061 13.1 0.8 0.2 11.5 0.6 1.8 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L27 UTP15_C PF09384.10 KII63657.1 - 1.2e-18 67.2 0.1 2e-18 66.5 0.1 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 KII63657.1 - 9.6e-12 45.2 24.1 0.0054 17.6 0.3 6.3 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII63657.1 - 3.8e-07 30.3 1.0 0.42 10.9 0.2 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KII63657.1 - 0.013 14.5 0.8 0.83 8.5 0.0 3.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GDP_Man_Dehyd PF16363.5 KII63658.1 - 6.1e-27 94.9 0.0 6.8e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KII63658.1 - 1.2e-18 67.4 0.1 1.9e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 KII63658.1 - 0.1 11.8 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein DDE_3 PF13358.6 KII63660.1 - 5.8e-21 74.8 0.0 7.3e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease EspG PF06872.11 KII63660.1 - 0.029 13.0 0.0 0.039 12.5 0.0 1.1 1 0 0 1 1 1 0 EspG protein OMS28_porin PF03532.13 KII63661.1 - 0.0037 16.5 0.2 0.0053 16.0 0.2 1.2 1 0 0 1 1 1 1 OMS28 porin DUF4313 PF14190.6 KII63663.1 - 0.077 13.0 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4313) DUF1759 PF03564.15 KII63665.1 - 3.8e-21 75.6 0.2 5.5e-21 75.1 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Endonuc-MspI PF09208.10 KII63665.1 - 0.023 14.1 0.1 0.033 13.6 0.1 1.4 1 0 0 1 1 1 0 Restriction endonuclease MspI DUF4738 PF15889.5 KII63665.1 - 0.39 10.5 2.4 0.46 10.3 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4738) DnaJ PF00226.31 KII63666.1 - 8.5e-25 86.7 1.7 1.2e-24 86.2 1.7 1.2 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 KII63667.1 - 3.4e-11 43.4 0.0 4.5e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KII63667.1 - 6.9e-10 39.1 11.8 1.1e-09 38.5 11.8 1.4 1 0 0 1 1 1 1 DnaJ central domain CxC3 PF18804.1 KII63667.1 - 3.1e-05 23.8 1.5 3.1e-05 23.8 1.5 1.5 1 1 1 2 2 2 1 CxC3 like cysteine cluster associated with KDZ transposases Anti-TRAP PF15777.5 KII63667.1 - 0.02 14.9 12.4 0.42 10.6 2.9 2.6 2 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-C4H2 PF10146.9 KII63667.1 - 0.17 12.1 0.2 0.27 11.5 0.2 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF5351 PF17302.2 KII63667.1 - 0.48 10.6 24.9 4.8 7.5 0.7 4.8 5 0 0 5 5 5 0 Family of unknown function (DUF5351) DUF2318 PF10080.9 KII63667.1 - 1.3 9.2 10.8 8.3 6.6 4.1 2.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) Zf_RING PF16744.5 KII63667.1 - 3.1 8.0 7.9 0.47 10.6 0.8 2.4 1 1 1 2 2 2 0 KIAA1045 RING finger Lar_restr_allev PF14354.6 KII63667.1 - 5.3 7.5 8.7 3.3 8.2 3.9 2.7 1 1 1 2 2 2 0 Restriction alleviation protein Lar C1_1 PF00130.22 KII63667.1 - 9.5 6.2 8.8 8.7 6.3 1.2 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Utp12 PF04003.12 KII63668.1 - 1.4e-08 35.0 0.9 2e-08 34.5 0.9 1.2 1 0 0 1 1 1 1 Dip2/Utp12 Family WAPL PF07814.13 KII63668.1 - 0.014 14.2 0.9 0.016 14.0 0.9 1.2 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin NUDIX PF00293.28 KII63670.1 - 1.2e-17 64.2 0.0 1.7e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Toxin_8 PF07365.12 KII63670.1 - 0.085 13.0 0.3 0.16 12.2 0.3 1.4 1 0 0 1 1 1 0 Alpha conotoxin precursor RNase_T PF00929.24 KII63671.1 - 0.002 18.7 0.5 0.0036 17.9 0.5 1.4 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 KII63671.1 - 0.0073 16.0 1.4 0.3 10.8 1.4 2.2 1 1 0 1 1 1 1 3'-5' exonuclease NepR PF18557.1 KII63671.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Anti-sigma factor NepR Rad21_Rec8_N PF04825.13 KII63671.1 - 0.11 12.7 0.1 0.15 12.3 0.1 1.2 1 0 0 1 1 1 0 N terminus of Rad21 / Rec8 like protein DR2241 PF18069.1 KII63672.1 - 0.14 12.1 0.0 1.5 8.7 0.1 2.1 2 0 0 2 2 2 0 DR2241 stabilising domain SEA PF01390.20 KII63673.1 - 8.4e-05 22.6 0.0 0.00025 21.1 0.0 1.8 1 0 0 1 1 1 1 SEA domain Ribosomal_L7Ae PF01248.26 KII63674.1 - 6.2e-11 41.9 0.1 1.8e-10 40.4 0.0 1.7 1 1 1 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Vps52 PF04129.12 KII63675.1 - 0.00047 19.0 1.2 0.00079 18.3 0.2 1.8 1 1 0 1 1 1 1 Vps52 / Sac2 family RVT_1 PF00078.27 KII63675.1 - 0.019 14.5 0.1 0.028 13.9 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) ISP1_C PF18161.1 KII63680.1 - 0.032 14.2 0.1 0.073 13.1 0.1 1.5 1 0 0 1 1 1 0 ISP1 C-terminal Lin-8 PF03353.15 KII63680.1 - 0.047 13.3 1.4 0.067 12.7 1.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF1242 PF06842.12 KII63680.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1242) MULE PF10551.9 KII63681.1 - 0.00068 20.0 0.0 0.0021 18.4 0.0 1.9 2 0 0 2 2 2 1 MULE transposase domain BAR PF03114.18 KII63681.1 - 0.17 11.5 0.1 0.27 10.8 0.1 1.3 1 0 0 1 1 1 0 BAR domain UPRTase PF14681.6 KII63682.1 - 7.3e-40 136.6 0.0 1e-39 136.1 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 KII63682.1 - 5.8e-31 107.8 0.1 1.1e-29 103.6 0.1 2.2 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 KII63682.1 - 1.9e-07 31.1 0.0 3.6e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 KII63682.1 - 2.2e-06 28.3 0.0 5.5e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KII63682.1 - 0.00019 21.9 0.3 0.00099 19.5 0.1 2.3 2 1 0 2 2 2 1 AAA domain CoaE PF01121.20 KII63682.1 - 0.00096 18.9 0.5 0.014 15.1 0.5 2.3 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 KII63682.1 - 0.004 17.3 0.0 0.0098 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Pribosyltran PF00156.27 KII63682.1 - 0.009 15.5 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Cytidylate_kin PF02224.18 KII63682.1 - 0.051 13.3 0.3 10 5.8 0.0 2.5 1 1 0 2 2 2 0 Cytidylate kinase Zeta_toxin PF06414.12 KII63682.1 - 0.056 12.7 0.0 0.15 11.3 0.0 1.8 1 1 0 1 1 1 0 Zeta toxin APS_kinase PF01583.20 KII63682.1 - 0.14 12.0 0.2 0.48 10.3 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase MFS_1 PF07690.16 KII63683.1 - 1.9e-25 89.6 31.4 1.4e-19 70.3 14.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Acatn PF13000.7 KII63684.1 - 1.4e-51 175.6 17.7 2e-51 175.1 17.7 1.2 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 DUF3561 PF12084.8 KII63684.1 - 0.084 12.9 0.2 0.084 12.9 0.2 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3561) MAPEG PF01124.18 KII63684.1 - 0.32 10.9 6.1 0.095 12.6 0.7 2.5 3 0 0 3 3 3 0 MAPEG family CLAMP PF14769.6 KII63686.1 - 0.00023 21.6 0.7 0.33 11.4 0.1 2.5 1 1 1 2 2 2 2 Flagellar C1a complex subunit C1a-32 C1_1 PF00130.22 KII63686.1 - 2.1 8.3 6.4 0.22 11.4 0.8 2.3 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) tRNA_lig_kinase PF08303.11 KII63687.1 - 0.036 14.2 0.4 0.036 14.2 0.4 2.2 2 1 0 2 2 2 0 tRNA ligase kinase domain DUF2116 PF09889.9 KII63687.1 - 0.33 11.0 2.6 1.8 8.6 0.7 2.5 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF4220 PF13968.6 KII63688.1 - 0.00025 20.6 0.4 0.00033 20.2 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4220) CDT1 PF08839.11 KII63690.1 - 0.058 13.7 0.4 0.06 13.6 0.4 1.1 1 0 0 1 1 1 0 DNA replication factor CDT1 like Sortilin_C PF15901.5 KII63692.1 - 1.3e-12 48.4 2.3 1.8e-12 47.9 2.3 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal MiAMP1 PF09117.10 KII63692.1 - 0.055 13.7 1.5 0.11 12.7 1.0 1.8 1 1 1 2 2 2 0 MiAMP1 Sortilin-Vps10 PF15902.5 KII63692.1 - 0.32 9.7 4.3 0.061 12.1 1.0 1.4 2 0 0 2 2 2 0 Sortilin, neurotensin receptor 3, Ras PF00071.22 KII63694.1 - 1.1e-13 51.1 0.1 1.7e-13 50.5 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII63694.1 - 3.8e-06 27.1 0.0 5.9e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KII63694.1 - 0.0029 17.5 0.9 0.5 10.2 0.1 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KII63694.1 - 0.017 15.5 0.0 0.021 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 KII63694.1 - 0.04 14.2 0.2 0.058 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 KII63694.1 - 0.041 13.2 0.1 0.08 12.3 0.1 1.4 1 0 0 1 1 1 0 KaiC Acatn PF13000.7 KII63694.1 - 0.047 12.2 0.1 0.05 12.1 0.1 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 AAA_7 PF12775.7 KII63694.1 - 0.055 13.0 0.1 0.36 10.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 KII63694.1 - 0.068 12.9 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_32 PF13654.6 KII63694.1 - 0.084 11.6 0.0 0.095 11.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KII63694.1 - 0.091 13.3 0.0 0.11 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KII63694.1 - 0.095 12.6 0.0 0.12 12.2 0.0 1.2 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea CbiA PF01656.23 KII63694.1 - 0.15 12.1 1.5 0.71 9.9 1.5 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Aminotran_1_2 PF00155.21 KII63695.1 - 3e-13 49.7 0.0 4.3e-12 45.9 0.0 2.2 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KII63695.1 - 0.17 10.4 0.0 0.27 9.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme ApeC PF16977.5 KII63696.1 - 1.4e-59 201.5 2.1 1.8e-59 201.2 2.1 1.1 1 0 0 1 1 1 1 C-terminal domain of apextrin Dimer_Tnp_hAT PF05699.14 KII63698.1 - 1.3e-07 31.3 0.1 1.7e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region ABC_tran PF00005.27 KII63699.1 - 5.4e-32 111.2 0.0 1e-14 55.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter RRM_1 PF00076.22 KII63699.1 - 2.6e-16 59.2 1.3 4.9e-16 58.3 0.3 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RLI PF04068.15 KII63699.1 - 1.5e-11 43.9 4.9 1.5e-11 43.9 4.9 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_15 PF13175.6 KII63699.1 - 2.1e-07 31.0 2.9 0.0013 18.5 1.8 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 KII63699.1 - 9.2e-07 29.2 1.0 3.2e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.27 KII63699.1 - 1.3e-06 27.9 2.7 1.3e-06 27.9 2.7 2.6 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_21 PF13304.6 KII63699.1 - 1.8e-06 28.0 3.2 0.083 12.7 0.0 3.7 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KII63699.1 - 5e-05 23.9 0.1 0.011 16.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KII63699.1 - 5.3e-05 22.9 0.1 0.18 11.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 KII63699.1 - 6.5e-05 23.4 0.0 0.038 14.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 KII63699.1 - 0.00013 21.5 6.5 0.024 14.1 0.1 4.4 2 2 1 3 3 3 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KII63699.1 - 0.00025 21.0 0.1 1.3 9.0 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase Rad17 PF03215.15 KII63699.1 - 0.00027 20.9 0.2 0.39 10.6 0.0 3.0 3 0 0 3 3 3 1 Rad17 P-loop domain NACHT PF05729.12 KII63699.1 - 0.00055 19.9 0.3 0.058 13.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Fer4_7 PF12838.7 KII63699.1 - 0.00075 20.0 5.3 0.012 16.2 0.1 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain SRP54 PF00448.22 KII63699.1 - 0.0012 18.5 0.9 0.19 11.4 0.0 2.9 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain Fer4_6 PF12837.7 KII63699.1 - 0.0023 17.9 12.6 0.0052 16.8 1.8 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_24 PF13479.6 KII63699.1 - 0.0025 17.6 0.4 0.3 10.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain VirE PF05272.11 KII63699.1 - 0.0029 17.4 0.0 2.8 7.6 0.0 2.6 2 0 0 2 2 2 1 Virulence-associated protein E Fer4_21 PF14697.6 KII63699.1 - 0.0054 16.8 13.6 0.013 15.6 13.6 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain AAA PF00004.29 KII63699.1 - 0.0087 16.5 0.1 3.6 8.0 0.1 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Fer4_10 PF13237.6 KII63699.1 - 0.0087 16.2 1.3 0.0087 16.2 1.3 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain G-alpha PF00503.20 KII63699.1 - 0.0094 15.1 0.2 0.61 9.2 0.4 2.5 1 1 0 2 2 2 1 G-protein alpha subunit Nup35_RRM_2 PF14605.6 KII63699.1 - 0.0094 15.9 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RNA_helicase PF00910.22 KII63699.1 - 0.0095 16.3 0.0 4.2 7.8 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 KII63699.1 - 0.0098 15.9 0.8 0.13 12.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Fer4_9 PF13187.6 KII63699.1 - 0.0098 16.0 11.4 0.02 15.1 11.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_18 PF13238.6 KII63699.1 - 0.015 15.8 1.1 9.3 6.8 0.2 3.0 2 2 0 2 2 2 0 AAA domain TsaE PF02367.17 KII63699.1 - 0.018 15.0 0.0 0.18 11.8 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_16 PF13484.6 KII63699.1 - 0.02 15.8 0.2 0.02 15.8 0.2 2.6 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain AAA_30 PF13604.6 KII63699.1 - 0.02 14.6 0.0 0.86 9.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_2 PF12797.7 KII63699.1 - 0.023 14.8 0.9 0.023 14.8 0.9 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain AAA_28 PF13521.6 KII63699.1 - 0.031 14.5 0.1 4.5 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KII63699.1 - 0.045 13.8 0.6 8.4 6.5 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.6 KII63699.1 - 0.069 13.3 0.3 15 5.7 0.0 3.1 2 1 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 KII63699.1 - 0.071 12.8 0.4 5 6.7 0.0 2.9 3 0 0 3 3 3 0 Thymidylate kinase Roc PF08477.13 KII63699.1 - 0.11 12.7 1.0 0.64 10.2 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 KII63699.1 - 0.49 9.9 2.8 1.6 8.2 0.0 2.9 4 0 0 4 4 3 0 P-loop containing dynein motor region Fer4_8 PF13183.6 KII63699.1 - 0.6 10.6 8.5 0.49 10.9 0.8 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain Myotub-related PF06602.14 KII63701.1 - 5.3e-120 400.6 1.7 7.4e-120 400.1 1.7 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 KII63701.1 - 0.088 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family IQ PF00612.27 KII63703.1 - 0.0085 15.8 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 IQ calmodulin-binding motif A1_Propeptide PF07966.12 KII63703.1 - 0.16 11.9 0.4 0.45 10.4 0.1 1.9 2 0 0 2 2 2 0 A1 Propeptide Sortilin_C PF15901.5 KII63706.1 - 2.4e-14 54.0 3.0 3.1e-14 53.7 3.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII63706.1 - 2.2e-07 30.1 0.1 3.2e-06 26.2 0.1 2.1 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, CHB_HEX_C PF03174.13 KII63706.1 - 0.18 11.8 0.0 0.48 10.4 0.0 1.7 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain Ldl_recept_a PF00057.18 KII63707.1 - 1.3e-07 31.7 7.9 1.3e-07 31.7 7.9 4.0 4 0 0 4 4 4 2 Low-density lipoprotein receptor domain class A Pkinase PF00069.25 KII63709.1 - 5.2e-49 167.0 0.1 7.5e-49 166.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII63709.1 - 6.6e-25 87.9 0.0 8.6e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KII63709.1 - 0.0036 16.7 0.1 0.0061 15.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KII63709.1 - 0.0072 15.7 0.0 0.11 11.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.20 KII63709.1 - 0.011 15.3 0.7 0.019 14.5 0.7 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 KII63709.1 - 0.02 14.8 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family FLYWCH PF04500.16 KII63711.1 - 2e-06 27.8 0.7 2.9e-06 27.3 0.7 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain XRN_M PF17846.1 KII63712.1 - 6.7e-53 180.2 2.9 8.8e-53 179.8 2.9 1.1 1 0 0 1 1 1 1 Xrn1 helical domain APG6_N PF17675.1 KII63712.1 - 0.19 12.2 1.1 0.31 11.6 1.1 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region HTH_57 PF18679.1 KII63715.1 - 0.1 12.9 0.1 0.13 12.6 0.1 1.2 1 0 0 1 1 1 0 ThcOx helix turn helix domain MMS1_N PF10433.9 KII63716.1 - 7.2e-58 196.4 1.1 7.2e-58 196.4 1.1 3.1 3 1 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KII63716.1 - 2.2e-35 122.5 0.4 1.5e-33 116.5 0.2 3.0 3 0 0 3 3 3 1 CPSF A subunit region V-set_2 PF15910.5 KII63716.1 - 0.012 15.7 0.7 0.042 14.0 0.4 2.0 2 0 0 2 2 2 0 ICOS V-set domain DDE_3 PF13358.6 KII63717.1 - 5.1e-06 26.3 0.0 8.5e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 KII63717.1 - 2.4e-05 24.1 0.1 4.5e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Tc3 transposase Sigma70_r4_2 PF08281.12 KII63717.1 - 0.11 12.2 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Ribosomal_L24e PF01246.20 KII63719.1 - 2.3e-28 98.2 5.3 2.3e-28 98.2 5.3 2.3 2 0 0 2 2 2 1 Ribosomal protein L24e NINJA_B PF16136.5 KII63719.1 - 0.053 13.9 1.4 0.091 13.1 1.4 1.3 1 0 0 1 1 1 0 Putative nuclear localisation signal PIN_12 PF16289.5 KII63719.1 - 0.13 12.8 6.1 0.18 12.3 6.1 1.1 1 0 0 1 1 1 0 PIN domain Macscav_rec PF03523.13 KII63722.1 - 0.2 11.6 1.6 0.73 9.8 0.6 2.2 2 0 0 2 2 2 0 Macrophage scavenger receptor RVT_1 PF00078.27 KII63723.1 - 1e-06 28.5 0.8 1e-06 28.5 0.8 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) T_Ag_DNA_bind PF02217.16 KII63723.1 - 0.086 13.5 0.6 0.1 13.2 0.6 1.2 1 0 0 1 1 1 0 Origin of replication binding protein P53_tetramer PF07710.11 KII63723.1 - 0.1 12.0 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 P53 tetramerisation motif DUF4500 PF14937.6 KII63727.1 - 0.099 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) PDDEXK_2 PF12784.7 KII63728.1 - 0.05 13.1 0.3 0.068 12.7 0.3 1.1 1 0 0 1 1 1 0 PD-(D/E)XK nuclease family transposase Vac14_Fab1_bd PF12755.7 KII63729.1 - 0.031 14.9 0.4 0.037 14.6 0.4 1.3 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region KDZ PF18758.1 KII63731.1 - 0.091 12.4 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Kyakuja-Dileera-Zisupton transposase DUF2719 PF10891.8 KII63732.1 - 0.081 12.8 0.4 0.24 11.3 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) YafO_toxin PF13957.6 KII63732.1 - 2.6 8.1 6.7 2.4 8.3 1.1 2.7 2 2 1 3 3 3 0 Toxin YafO, type II toxin-antitoxin system HTH_Tnp_4 PF13613.6 KII63733.1 - 0.0035 17.0 0.4 7.3 6.4 0.1 3.1 3 0 0 3 3 3 2 Helix-turn-helix of DDE superfamily endonuclease BrkDBD PF09607.10 KII63733.1 - 0.011 15.5 0.1 0.022 14.5 0.1 1.5 1 0 0 1 1 1 0 Brinker DNA-binding domain Phage_terminase PF10668.9 KII63733.1 - 0.053 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Phage terminase small subunit HTH_Tnp_1 PF01527.20 KII63733.1 - 0.15 12.4 0.4 0.22 11.8 0.0 1.4 2 0 0 2 2 2 0 Transposase DUF3467 PF11950.8 KII63734.1 - 0.16 12.1 0.1 0.23 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3467) Ribosomal_S9 PF00380.19 KII63736.1 - 3.9e-31 108.1 0.6 5.2e-31 107.7 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Mistic PF11458.8 KII63736.1 - 0.18 11.8 0.5 4.2 7.4 0.1 2.7 2 1 1 3 3 3 0 Membrane-integrating protein Mistic Slu7 PF11708.8 KII63737.1 - 5.5e-86 288.7 5.7 5.5e-86 288.7 5.7 1.8 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.23 KII63737.1 - 0.64 10.2 3.1 1 9.5 3.1 1.4 1 0 0 1 1 1 0 Zinc knuckle CLPTM1 PF05602.12 KII63739.1 - 1.5e-107 360.3 9.7 1.8e-107 360.0 9.7 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 KII63739.1 - 0.069 12.9 4.1 0.61 9.9 0.2 3.0 2 0 0 2 2 2 0 PQ loop repeat Ribosomal_S10 PF00338.22 KII63740.1 - 1.6e-22 79.5 0.1 3.3e-22 78.5 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF5001 PF16392.5 KII63740.1 - 0.044 13.7 0.7 0.083 12.8 0.2 1.8 2 0 0 2 2 2 0 Ig-like domain Rhabdo_M1 PF03342.13 KII63742.1 - 0.032 13.6 0.0 0.055 12.8 0.0 1.5 1 0 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) zf-UBR PF02207.20 KII63745.1 - 6.8e-17 61.4 13.0 2.1e-16 59.8 13.0 1.9 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ACR_tran PF00873.19 KII63748.1 - 1.1e-154 516.6 9.9 1.2e-154 516.5 9.9 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 KII63748.1 - 0.33 9.8 5.6 0.062 12.2 1.3 1.9 2 1 1 3 3 3 0 MMPL family PIN_8 PF18476.1 KII63749.1 - 0.0092 15.9 0.1 0.01 15.7 0.1 1.0 1 0 0 1 1 1 1 PIN like domain Toprim_Crpt PF13342.6 KII63749.1 - 0.14 12.1 0.0 9.4 6.3 0.0 2.5 1 1 1 2 2 2 0 C-terminal repeat of topoisomerase GWT1 PF06423.12 KII63750.1 - 0.28 11.3 2.4 0.14 12.3 0.3 1.6 2 0 0 2 2 2 0 GWT1 DUF148 PF02520.17 KII63751.1 - 0.0014 18.7 4.2 0.0032 17.6 4.1 1.6 1 1 1 2 2 2 1 Domain of unknown function DUF148 SlyX PF04102.12 KII63751.1 - 0.0032 18.0 1.7 0.011 16.3 0.6 2.0 2 0 0 2 2 2 1 SlyX KIP1 PF07765.12 KII63751.1 - 0.23 11.6 3.2 0.32 11.1 0.1 2.1 1 1 0 2 2 2 0 KIP1-like protein PGA2 PF07543.12 KII63753.1 - 0.056 13.4 0.2 0.12 12.3 0.2 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF1959 PF09218.10 KII63754.1 - 0.06 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) O-FucT PF10250.9 KII63755.1 - 3.1e-05 23.9 0.2 6.9e-05 22.7 0.1 1.5 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase O-FucT PF10250.9 KII63756.1 - 1.1e-05 25.3 0.3 3.1e-05 23.8 0.2 1.4 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase NodZ PF05830.11 KII63756.1 - 0.001 18.0 0.0 0.0026 16.6 0.0 1.6 2 0 0 2 2 2 1 Nodulation protein Z (NodZ) DUF1959 PF09218.10 KII63759.1 - 0.056 13.6 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) DUF3445 PF11927.8 KII63761.1 - 0.045 13.4 0.1 0.21 11.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3445) NmrA PF05368.13 KII63765.1 - 0.087 12.4 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 NmrA-like family Lysis_col PF02402.16 KII63766.1 - 0.058 13.1 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 Lysis protein OTT_1508_deam PF14441.6 KII63767.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 OTT_1508-like deaminase DDE_3 PF13358.6 KII63768.1 - 0.00099 18.9 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4573 PF15140.6 KII63769.1 - 5.4e-06 26.3 5.2 6.6e-05 22.8 5.2 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4573) DUF3339 PF11820.8 KII63771.1 - 0.24 11.6 1.1 5 7.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3339) DDE_3 PF13358.6 KII63775.1 - 1.6e-07 31.2 0.0 6.8e-07 29.1 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease Metallophos PF00149.28 KII63776.1 - 1.3e-09 38.9 0.4 1.9e-09 38.3 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4516 PF14990.6 KII63777.1 - 0.16 11.7 2.4 1.8 8.4 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4516) MrpF_PhaF PF04066.13 KII63777.1 - 1.3 9.5 9.1 0.31 11.5 5.1 2.1 2 0 0 2 2 2 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) S_4TM PF18159.1 KII63778.1 - 0.015 14.6 1.2 0.015 14.6 1.2 1.5 1 1 1 2 2 2 0 SMODS-associating 4TM effector domain TMEM208_SND2 PF05620.11 KII63778.1 - 0.12 12.2 0.2 0.12 12.2 0.2 2.0 1 1 1 2 2 2 0 SRP-independent targeting protein 2/TMEM208 PIG-Y PF15159.6 KII63778.1 - 0.47 11.4 5.0 0.75 10.8 5.0 1.3 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y TNFR_16_TM PF18422.1 KII63778.1 - 1.2 9.1 6.3 5.1 7.1 0.7 2.3 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain TMEM154 PF15102.6 KII63778.1 - 4.2 7.3 4.9 5.5 6.9 1.5 2.0 1 1 1 2 2 2 0 TMEM154 protein family FeoB_associated PF12669.7 KII63778.1 - 8.4 6.9 5.7 26 5.3 0.2 2.5 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein rve PF00665.26 KII63782.1 - 1.7e-15 57.2 0.0 3.3e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII63782.1 - 0.00068 19.4 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF2753 PF10952.8 KII63786.1 - 0.047 13.8 0.2 0.68 10.1 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2753) Rota_NS6 PF04866.12 KII63786.1 - 0.051 13.8 0.0 0.77 10.0 0.0 2.5 2 0 0 2 2 2 0 Rotavirus non-structural protein 6 TetR_C_22 PF17928.1 KII63786.1 - 0.068 13.5 0.0 8.4 6.8 0.0 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF2157 PF09925.9 KII63788.1 - 2.8 7.7 8.7 0.055 13.3 1.8 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Claudin_2 PF13903.6 KII63789.1 - 0.049 13.4 0.6 0.049 13.4 0.6 2.0 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.6 KII63789.1 - 0.26 11.6 14.0 1.9 8.8 14.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) DUF3671 PF12420.8 KII63789.1 - 0.32 11.1 4.5 0.74 9.9 4.5 1.6 1 1 0 1 1 1 0 Protein of unknown function PMP22_Claudin PF00822.20 KII63789.1 - 0.56 10.1 7.7 3.3 7.6 7.7 2.0 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family OPA3 PF07047.12 KII63790.1 - 0.092 12.5 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) RVT_1 PF00078.27 KII63791.1 - 8.4e-26 90.9 0.3 1.7e-25 89.9 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 KII63791.1 - 0.18 12.1 0.0 0.75 10.1 0.0 2.1 2 0 0 2 2 2 0 Retroviral aspartyl protease Metallophos PF00149.28 KII63794.1 - 0.0071 16.9 5.1 0.51 10.8 0.3 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase POB3_N PF17292.2 KII63794.1 - 0.13 12.7 0.1 0.45 11.0 0.1 1.9 2 0 0 2 2 2 0 POB3-like N-terminal PH domain VASt PF16016.5 KII63795.1 - 8.5e-08 32.7 1.3 1e-07 32.4 1.3 1.1 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 KII63796.1 - 5.4e-16 58.5 0.2 1e-15 57.6 0.2 1.4 1 0 0 1 1 1 1 GRAM domain DEAD PF00270.29 KII63798.1 - 1.5e-38 132.3 0.0 2.4e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII63798.1 - 4e-30 104.4 0.2 1.3e-28 99.6 0.1 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII63798.1 - 1.4e-05 25.1 0.0 5.5e-05 23.2 0.0 1.8 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KII63798.1 - 0.035 13.5 0.1 0.24 10.7 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 KII63798.1 - 0.047 14.0 0.3 1 9.7 0.0 2.8 2 1 0 2 2 2 0 AAA domain SMC_N PF02463.19 KII63798.1 - 0.088 12.2 0.1 0.18 11.2 0.1 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain tRNA-synt_1b PF00579.25 KII63798.1 - 0.1 11.9 0.0 6.6 6.0 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) AAA_30 PF13604.6 KII63798.1 - 0.11 12.2 0.0 0.38 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Guanylate_kin PF00625.21 KII63799.1 - 1.6e-06 27.9 0.0 1.9e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase DUF1289 PF06945.13 KII63799.1 - 0.097 12.5 0.9 0.2 11.5 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) EF-hand_1 PF00036.32 KII63800.1 - 1.6e-13 49.2 5.5 1.9e-06 27.0 1.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KII63800.1 - 4.8e-13 47.9 4.3 9.2e-06 25.2 0.9 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KII63800.1 - 5.1e-12 46.1 4.3 7.4e-12 45.6 4.0 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KII63800.1 - 7.1e-11 41.8 3.0 5.3e-05 23.0 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KII63800.1 - 1.6e-08 33.7 3.2 2.7e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 EF hand Sin3a_C PF16879.5 KII63800.1 - 0.00048 19.9 0.2 0.00056 19.7 0.2 1.1 1 0 0 1 1 1 1 C-terminal domain of Sin3a protein SPARC_Ca_bdg PF10591.9 KII63800.1 - 0.0019 18.5 0.5 0.01 16.1 0.4 1.9 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KII63800.1 - 0.005 16.8 3.1 1 9.3 0.8 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand RST PF12174.8 KII63800.1 - 0.11 12.5 0.7 1.3 9.0 0.1 2.1 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain PMBR PF09373.10 KII63800.1 - 0.11 12.6 0.5 2.3 8.5 0.1 2.5 3 0 0 3 3 3 0 Pseudomurein-binding repeat ERAP1_C PF11838.8 KII63800.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 ERAP1-like C-terminal domain EF-hand_6 PF13405.6 KII63801.1 - 0.0013 18.5 0.9 0.18 11.8 0.7 2.8 1 1 1 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KII63801.1 - 0.0025 17.3 0.7 0.07 12.7 0.1 2.6 2 1 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KII63801.1 - 0.019 15.4 0.2 0.45 11.0 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair DUF3641 PF12345.8 KII63801.1 - 0.1 12.6 0.5 0.13 12.3 0.4 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3641) DUF3507 PF12015.8 KII63804.1 - 0.055 13.2 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) MIT_C PF16565.5 KII63805.1 - 1.9e-41 141.4 1.2 3.3e-41 140.6 0.1 1.8 2 0 0 2 2 2 1 Phospholipase D-like domain at C-terminus of MIT MIT PF04212.18 KII63805.1 - 2.2e-08 34.1 0.4 4.5e-08 33.0 0.4 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Use1 PF09753.9 KII63805.1 - 0.0017 18.2 1.5 0.0021 17.8 1.5 1.3 1 1 0 1 1 1 1 Membrane fusion protein Use1 DUF327 PF03885.13 KII63805.1 - 0.084 12.8 3.2 0.95 9.4 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF327) RVP PF00077.20 KII63807.1 - 0.011 16.0 0.0 0.045 14.1 0.0 2.1 2 1 0 2 2 2 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII63807.1 - 0.012 16.2 0.0 0.073 13.6 0.0 2.3 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease AT_hook PF02178.19 KII63807.1 - 6.4 7.0 8.0 0.58 10.2 1.4 2.5 2 0 0 2 2 2 0 AT hook motif DUF2207 PF09972.9 KII63808.1 - 0.022 13.5 0.0 0.023 13.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2569 PF10754.9 KII63808.1 - 0.027 14.9 0.0 0.034 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Amnionless PF14828.6 KII63808.1 - 0.045 12.6 0.0 0.045 12.6 0.0 1.2 1 0 0 1 1 1 0 Amnionless Syndecan PF01034.20 KII63808.1 - 0.32 10.9 2.2 0.52 10.3 2.2 1.3 1 0 0 1 1 1 0 Syndecan domain DUF3824 PF12868.7 KII63809.1 - 2 9.0 12.6 2.9 8.5 12.6 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) EGF_Tenascin PF18720.1 KII63810.1 - 0.00018 21.5 3.1 0.00045 20.2 3.1 1.7 1 0 0 1 1 1 1 Tenascin EGF domain EGF_2 PF07974.13 KII63810.1 - 0.003 17.9 7.1 0.0094 16.3 7.1 1.9 1 0 0 1 1 1 1 EGF-like domain Integrin_beta PF00362.18 KII63811.1 - 5.9e-19 68.7 0.0 8e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain I-EGF_1 PF18372.1 KII63811.1 - 0.54 10.4 0.1 0.54 10.4 0.1 3.5 3 0 0 3 3 3 0 Integrin beta epidermal growth factor like domain 1 PTP_tm PF18861.1 KII63812.1 - 0.068 13.2 0.0 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J EGF_2 PF07974.13 KII63814.1 - 0.00025 21.3 47.4 0.0014 19.0 16.6 3.5 2 1 1 3 3 3 2 EGF-like domain I-EGF_1 PF18372.1 KII63814.1 - 0.11 12.6 31.6 0.33 11.1 13.1 3.1 2 1 0 2 2 2 0 Integrin beta epidermal growth factor like domain 1 GWT1 PF06423.12 KII63814.1 - 0.2 11.8 1.5 0.32 11.1 1.5 1.3 1 0 0 1 1 1 0 GWT1 RT_RNaseH_2 PF17919.1 KII63815.1 - 2.7e-10 40.2 0.1 7.9e-05 22.6 0.0 2.7 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63815.1 - 0.00023 21.4 0.2 0.29 11.4 0.0 2.5 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Integrin_beta PF00362.18 KII63816.1 - 5.7e-07 29.5 1.2 0.0031 17.2 0.1 2.0 1 1 1 2 2 2 2 Integrin beta chain VWA domain Integrin_beta PF00362.18 KII63819.1 - 1.3e-11 44.6 0.0 2.5e-07 30.6 0.0 2.1 1 1 1 2 2 2 2 Integrin beta chain VWA domain PSI PF01437.25 KII63819.1 - 0.0072 16.8 0.4 0.013 16.0 0.4 1.4 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.3 KII63819.1 - 0.015 15.0 1.4 0.027 14.2 1.4 1.4 1 0 0 1 1 1 0 Integrin plexin domain EGF_2 PF07974.13 KII63820.1 - 5.7e-07 29.8 78.8 0.00035 20.9 15.7 5.5 4 1 0 5 5 5 4 EGF-like domain I-EGF_1 PF18372.1 KII63820.1 - 0.013 15.6 10.2 0.013 15.6 10.2 5.9 5 2 0 5 5 5 0 Integrin beta epidermal growth factor like domain 1 DUF4468 PF14730.6 KII63822.1 - 0.016 15.5 0.4 0.054 13.8 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold DUF1366 PF07104.11 KII63822.1 - 0.068 12.9 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) Zip PF02535.22 KII63824.1 - 0.11 11.6 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 KII63824.1 - 0.14 12.2 1.4 0.17 11.9 1.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Cytomega_TRL10 PF06084.11 KII63824.1 - 0.19 11.7 0.0 0.27 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein Presenilin PF01080.17 KII63824.1 - 0.68 8.6 4.0 0.79 8.4 4.0 1.2 1 0 0 1 1 1 0 Presenilin HI0933_like PF03486.14 KII63824.1 - 1.8 7.2 6.0 2.1 7.0 6.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Ndc1_Nup PF09531.10 KII63824.1 - 2.1 6.9 8.2 2.3 6.8 8.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ALMT PF11744.8 KII63824.1 - 7.6 5.2 5.8 9.1 5.0 5.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter partial_CstF PF15861.5 KII63825.1 - 0.13 12.1 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain AsnC_trans_reg2 PF17805.1 KII63826.1 - 0.028 14.6 0.3 0.039 14.1 0.3 1.3 1 0 0 1 1 1 0 AsnC-like ligand binding domain DDE_Tnp_IS1595 PF12762.7 KII63827.1 - 7.9e-15 55.2 0.0 1.1e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain SNAP PF14938.6 KII63828.1 - 2.6e-06 27.1 0.7 2.6e-06 27.1 0.7 1.6 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP HTH_23 PF13384.6 KII63830.1 - 1.1e-05 25.0 0.0 2.6e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 KII63830.1 - 0.00098 19.1 0.1 0.0017 18.3 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 KII63830.1 - 0.003 17.6 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.18 KII63830.1 - 0.0037 17.2 0.1 0.0055 16.6 0.1 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_33 PF13592.6 KII63830.1 - 0.037 13.7 0.0 0.079 12.6 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix Peptidase_C1 PF00112.23 KII63831.1 - 2.9e-73 246.6 2.1 3.7e-73 246.2 2.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII63831.1 - 5.4e-08 33.2 1.1 5.4e-08 33.2 1.1 2.0 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) DUF4093 PF13331.6 KII63831.1 - 0.034 14.6 0.3 13 6.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4093) Peptidase_C1_2 PF03051.15 KII63831.1 - 0.055 12.2 0.3 0.1 11.4 0.3 1.3 1 0 0 1 1 1 0 Peptidase C1-like family Peptidase_C1 PF00112.23 KII63832.1 - 1.6e-67 227.8 6.6 2e-67 227.5 6.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII63832.1 - 1.3e-08 35.2 0.8 3.6e-08 33.7 0.8 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KII63832.1 - 0.002 17.0 0.6 0.0035 16.2 0.6 1.3 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C39_2 PF13529.6 KII63832.1 - 0.0062 17.1 0.9 0.027 15.0 0.3 2.1 2 1 0 2 2 2 1 Peptidase_C39 like family RT_RNaseH_2 PF17919.1 KII63833.1 - 2.1e-34 117.5 0.0 1.2e-33 115.2 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII63833.1 - 3.9e-34 118.1 0.1 8.3e-34 117.0 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII63833.1 - 1.7e-32 111.9 0.0 1.3e-31 109.0 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII63833.1 - 3.5e-20 72.4 0.0 1e-19 70.9 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63833.1 - 3.4e-18 65.5 0.4 9.3e-18 64.1 0.4 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII63833.1 - 4e-07 30.5 0.0 1.1e-06 29.1 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-H2C2 PF09337.10 KII63833.1 - 7.9e-05 22.8 0.1 0.001 19.3 0.0 2.5 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII63833.1 - 0.00026 20.7 0.3 0.0032 17.2 0.0 2.7 2 0 0 2 2 2 1 Integrase core domain Retrotrans_gag PF03732.17 KII63833.1 - 0.00051 20.3 0.1 0.0019 18.4 0.1 2.0 1 0 0 1 1 1 1 Retrotransposon gag protein Asp_protease_2 PF13650.6 KII63833.1 - 0.00069 20.2 0.0 0.0018 18.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII63833.1 - 0.0015 18.5 0.4 0.0015 18.5 0.4 2.4 2 0 0 2 2 2 1 Zinc knuckle RVP PF00077.20 KII63833.1 - 0.0032 17.7 0.1 0.017 15.4 0.1 2.4 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII63833.1 - 0.005 16.6 0.2 0.013 15.3 0.2 1.7 1 0 0 1 1 1 1 Aspartyl protease Spuma_A9PTase PF03539.14 KII63833.1 - 0.014 15.5 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) DUF2014 PF09427.10 KII63833.1 - 0.079 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) zf-CCHC_5 PF14787.6 KII63833.1 - 1.1 9.0 4.8 0.43 10.3 1.4 2.1 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Tetraspanin PF00335.20 KII63834.1 - 1.1e-15 58.0 14.5 1.3e-15 57.8 14.5 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF21 PF01595.20 KII63834.1 - 0.007 16.1 0.5 0.012 15.4 0.5 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain YjcB PF15940.5 KII63834.1 - 0.17 12.1 2.8 0.3 11.3 2.1 1.8 1 1 1 2 2 2 0 Family of unknown function Radical_SAM_C PF16199.5 KII63838.1 - 2.6e-25 88.3 0.1 5.2e-25 87.3 0.1 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KII63838.1 - 4.3e-15 56.5 0.2 1.1e-14 55.2 0.1 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 KII63838.1 - 5.6e-05 23.4 0.5 0.00014 22.1 0.5 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII63838.1 - 0.0031 17.5 0.2 0.0067 16.4 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zf-C2H2 PF00096.26 KII63839.1 - 4.7e-05 23.6 13.6 0.026 15.0 1.4 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII63839.1 - 0.00029 21.4 11.2 0.0077 17.0 1.9 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 KII63839.1 - 0.0054 17.3 4.1 0.22 12.2 0.2 2.7 2 0 0 2 2 2 1 FOXP coiled-coil domain zf-BED PF02892.15 KII63839.1 - 0.017 15.1 0.8 0.017 15.1 0.8 1.9 2 0 0 2 2 2 0 BED zinc finger zf-met PF12874.7 KII63839.1 - 0.02 15.3 0.5 0.02 15.3 0.5 3.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KII63839.1 - 0.19 12.1 3.8 0.66 10.3 3.8 1.9 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 KII63839.1 - 0.38 11.3 0.1 0.38 11.3 0.1 3.6 4 0 0 4 4 4 0 Zinc-finger double domain Ribosomal_L30 PF00327.20 KII63840.1 - 1.1e-19 70.1 2.2 1.1e-19 70.1 2.2 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 KII63840.1 - 9.1e-16 57.9 15.1 1.6e-15 57.1 15.1 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Snf7 PF03357.21 KII63841.1 - 8.5e-33 113.4 14.7 1e-32 113.1 14.7 1.1 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 KII63841.1 - 0.00081 19.8 3.1 0.015 15.7 0.2 2.6 3 0 0 3 3 3 1 Nucleopolyhedrovirus P10 protein Eaf7 PF07904.13 KII63841.1 - 0.0025 18.1 0.5 0.0025 18.1 0.5 2.1 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 RACo_C_ter PF14574.6 KII63841.1 - 0.0028 16.8 1.6 0.0037 16.3 1.3 1.4 1 1 0 1 1 1 1 C-terminal domain of RACo the ASKHA domain Sugarporin_N PF11471.8 KII63841.1 - 0.0045 16.9 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension ABC_tran_CTD PF16326.5 KII63841.1 - 0.0045 17.2 2.9 0.0045 17.2 2.9 3.0 2 1 1 3 3 3 1 ABC transporter C-terminal domain Rx_N PF18052.1 KII63841.1 - 0.025 14.8 10.6 0.053 13.8 0.9 2.8 1 1 2 3 3 3 0 Rx N-terminal domain DUF2312 PF10073.9 KII63841.1 - 0.026 14.2 2.7 0.026 14.2 2.7 2.9 3 1 1 4 4 3 0 Uncharacterized protein conserved in bacteria (DUF2312) HATPase_c_5 PF14501.6 KII63841.1 - 0.051 13.5 0.3 0.09 12.7 0.3 1.4 1 0 0 1 1 1 0 GHKL domain Vac_Fusion PF02346.16 KII63841.1 - 0.062 12.9 2.3 5.5 6.7 0.1 2.8 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Fib_alpha PF08702.10 KII63841.1 - 0.099 12.8 9.9 0.13 12.5 8.9 1.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 KII63841.1 - 0.1 13.0 6.7 1.3 9.5 0.2 3.3 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) T3SS_needle_E PF08988.10 KII63841.1 - 0.25 11.5 3.1 0.55 10.4 1.0 2.5 2 1 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle TINF2_N PF14973.6 KII63841.1 - 0.27 11.6 5.4 0.11 12.8 1.9 2.0 1 1 1 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus DUF4363 PF14276.6 KII63841.1 - 0.65 10.1 5.8 1.2 9.3 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) DUF4140 PF13600.6 KII63841.1 - 0.83 10.1 4.9 0.42 11.1 0.5 2.5 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) GvpK PF05121.12 KII63841.1 - 0.89 9.6 4.3 6.1 7.0 1.3 2.4 2 0 0 2 2 2 0 Gas vesicle protein K DUF3847 PF12958.7 KII63841.1 - 3 8.0 8.9 31 4.8 5.3 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF3847) Uso1_p115_C PF04871.13 KII63841.1 - 3.1 8.2 16.6 4.6 7.6 13.4 2.5 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Swi5 PF07061.11 KII63841.1 - 3.4 7.8 8.8 5 7.3 2.7 3.2 3 1 0 3 3 3 0 Swi5 Seryl_tRNA_N PF02403.22 KII63841.1 - 3.8 7.8 14.4 8.2 6.7 4.7 2.8 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Fzo_mitofusin PF04799.13 KII63841.1 - 4.1 6.9 8.4 4 7.0 1.8 2.6 2 1 1 3 3 3 0 fzo-like conserved region YlqD PF11068.8 KII63841.1 - 5.6 7.3 14.4 23 5.4 9.2 2.3 1 1 0 2 2 2 0 YlqD protein FTCD_C PF04961.12 KII63841.1 - 7.7 6.2 8.3 3.1 7.5 2.1 2.5 2 1 1 3 3 3 0 Formiminotransferase-cyclodeaminase DUF2802 PF10975.8 KII63841.1 - 9.8 6.4 7.8 1.6 8.9 2.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2802) DDE_Tnp_IS1595 PF12762.7 KII63844.1 - 3.8e-12 46.5 0.1 4.3e-12 46.3 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain CTK3 PF12243.8 KII63846.1 - 0.059 13.4 0.1 0.081 12.9 0.1 1.3 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 HTH_45 PF14947.6 KII63847.1 - 0.069 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DDE_Tnp_IS1595 PF12762.7 KII63848.1 - 0.00027 21.0 0.1 0.0004 20.4 0.1 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Epimerase PF01370.21 KII63849.1 - 5.8e-07 29.2 0.0 1.1e-06 28.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KII63849.1 - 2.2e-06 27.0 0.0 2.8e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 KII63849.1 - 0.044 13.2 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF2012 PF09430.10 KII63850.1 - 5.7e-15 55.5 0.3 3.4e-14 53.0 0.3 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2012) SdrD_B PF17210.3 KII63850.1 - 0.085 13.1 0.1 0.17 12.1 0.0 1.5 1 1 0 1 1 1 0 SdrD B-like domain fn3_3 PF14686.6 KII63850.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II Aldedh PF00171.22 KII63851.1 - 2.4e-140 468.1 0.0 2.7e-140 467.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family HTH_33 PF13592.6 KII63854.1 - 1.3e-06 27.9 0.0 2.9e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 KII63854.1 - 3.6e-06 26.6 0.1 0.0013 18.5 0.0 2.5 2 0 0 2 2 2 2 Homeodomain-like domain CENP-B_N PF04218.13 KII63854.1 - 2.1e-05 24.0 0.0 0.018 14.7 0.0 2.3 2 0 0 2 2 2 2 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 KII63854.1 - 0.0004 20.4 0.0 0.022 14.9 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII63854.1 - 0.0012 19.0 0.1 0.0042 17.3 0.1 1.9 2 0 0 2 2 2 1 Transposase PAX PF00292.18 KII63854.1 - 0.0047 16.8 0.1 0.0097 15.8 0.1 1.4 1 1 0 1 1 1 1 'Paired box' domain CGI-121 PF08617.10 KII63854.1 - 0.0099 16.0 0.0 0.014 15.5 0.0 1.2 1 0 0 1 1 1 1 Kinase binding protein CGI-121 HTH_Tnp_ISL3 PF13542.6 KII63854.1 - 0.023 14.1 0.6 1.9 7.9 0.2 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 DUF4817 PF16087.5 KII63854.1 - 0.031 14.1 0.0 2.2 8.2 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) TrmB PF01978.19 KII63854.1 - 0.048 13.5 0.1 0.14 12.0 0.1 1.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_29 PF13551.6 KII63854.1 - 0.082 12.9 0.1 0.5 10.4 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix HTH_32 PF13565.6 KII63854.1 - 0.099 13.3 0.0 0.16 12.6 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain PSS PF03034.15 KII63855.1 - 3.3e-26 92.7 3.3 3.3e-26 92.7 3.3 1.4 2 0 0 2 2 2 1 Phosphatidyl serine synthase Amidase PF01425.21 KII63857.1 - 1.8e-08 33.8 0.0 2.1e-08 33.6 0.0 1.0 1 0 0 1 1 1 1 Amidase His_Phos_2 PF00328.22 KII63858.1 - 0.016 14.6 0.1 0.055 12.8 0.1 1.7 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) DDE_3 PF13358.6 KII63859.1 - 3.8e-13 49.4 0.0 4.6e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease CRIC_ras_sig PF10534.9 KII63859.1 - 0.062 13.5 0.0 0.09 13.0 0.0 1.2 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras BAH PF01426.18 KII63859.1 - 0.12 12.2 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 BAH domain DUF1132 PF06575.12 KII63861.1 - 0.13 12.7 5.2 0.18 12.2 2.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1132) Actin PF00022.19 KII63863.1 - 4.7e-15 55.1 0.0 1.4e-13 50.2 0.0 2.0 1 1 0 1 1 1 1 Actin EF-hand_5 PF13202.6 KII63864.1 - 2.5e-05 23.6 0.0 8.2e-05 21.9 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KII63864.1 - 0.00051 19.4 0.1 0.0019 17.6 0.1 2.0 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KII63864.1 - 0.00072 19.4 0.9 0.015 15.1 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KII63864.1 - 0.0062 16.4 1.2 0.017 15.0 0.0 2.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KII63864.1 - 0.0065 16.9 1.2 0.013 15.9 1.2 1.5 1 1 0 1 1 1 1 EF-hand domain pair Stap_Strp_tox_C PF02876.17 KII63864.1 - 0.032 14.5 1.3 0.047 14.0 1.3 1.3 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Malic_M PF03949.15 KII63864.1 - 0.036 13.3 0.0 0.06 12.6 0.0 1.4 1 1 0 1 1 1 0 Malic enzyme, NAD binding domain Gal-3-0_sulfotr PF06990.11 KII63866.1 - 4.7e-17 62.0 7.0 1.2e-15 57.3 7.0 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase DDE_Tnp_IS1595 PF12762.7 KII63867.1 - 0.14 12.1 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain BIR PF00653.21 KII63870.1 - 0.0014 19.3 5.8 0.53 11.0 0.5 2.3 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain Erv26 PF04148.13 KII63870.1 - 0.024 14.4 0.4 6.9 6.4 0.1 2.1 2 0 0 2 2 2 0 Transmembrane adaptor Erv26 DUF2809 PF10990.8 KII63870.1 - 0.039 14.6 0.1 14 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2809) Ribosomal_S12 PF17487.2 KII63870.1 - 0.076 13.8 7.1 2.9 8.7 0.8 2.1 2 0 0 2 2 2 0 Ribosomal protein S12 Oxidored-like PF09791.9 KII63870.1 - 0.2 11.4 7.6 3.3 7.4 0.9 2.4 2 0 0 2 2 2 0 Oxidoreductase-like protein, N-terminal LOH1CR12 PF10158.9 KII63870.1 - 0.25 11.3 0.1 21 5.2 0.0 2.1 2 0 0 2 2 2 0 Tumour suppressor protein DUF2544 PF11245.8 KII63871.1 - 0.029 13.8 0.1 0.042 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2544) Kelch_6 PF13964.6 KII63873.1 - 6e-14 51.7 6.1 2e-06 27.9 0.4 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII63873.1 - 1.7e-13 50.2 3.4 4.2e-06 26.6 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII63873.1 - 1.1e-11 44.5 1.1 0.0004 20.3 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII63873.1 - 1.1e-09 38.3 0.1 0.0023 18.2 0.1 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII63873.1 - 0.00024 20.6 3.8 0.063 12.9 0.1 3.3 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII63873.1 - 0.00025 20.9 3.1 4.3 7.5 0.1 3.4 3 0 0 3 3 3 3 Kelch motif rve PF00665.26 KII63874.1 - 2e-20 73.2 0.1 3e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII63874.1 - 5.2e-07 29.7 0.9 2.1e-06 27.7 0.6 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII63874.1 - 1e-05 25.2 0.0 2.5e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII63874.1 - 0.0009 19.4 0.1 0.0016 18.6 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger DDE_3 PF13358.6 KII63874.1 - 0.0024 17.6 0.1 0.0042 16.8 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Nepo_coat_N PF03689.15 KII63874.1 - 0.013 15.4 0.1 0.11 12.4 0.0 2.3 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Kelch_6 PF13964.6 KII63875.1 - 4.7e-30 102.9 8.0 1.7e-05 25.0 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KII63875.1 - 6.2e-24 83.3 9.6 1.7e-06 27.5 0.0 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII63875.1 - 7.7e-23 80.3 9.9 0.00033 20.6 0.1 6.5 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 KII63875.1 - 2.7e-19 68.3 3.8 1.7e-05 24.6 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII63875.1 - 1.6e-18 66.5 3.1 7.6e-05 22.9 0.1 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII63875.1 - 2.5e-13 49.7 6.0 0.0061 16.5 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 KII63876.1 - 1.4e-11 44.3 6.1 0.12 12.7 0.0 6.3 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII63876.1 - 9.7e-10 38.3 1.0 0.024 14.6 0.0 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII63876.1 - 0.0013 18.3 11.7 0.13 11.8 0.1 6.5 7 1 0 7 7 7 1 Kelch motif Kelch_5 PF13854.6 KII63876.1 - 0.0017 18.3 0.3 21 5.2 0.0 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 KII63876.1 - 0.21 11.6 7.6 22 5.2 0.0 5.2 6 0 0 6 6 6 0 Kelch motif Kelch_6 PF13964.6 KII63878.1 - 3.3e-23 81.1 4.5 2.6e-07 30.7 0.2 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII63878.1 - 9.1e-17 60.4 0.7 4.1e-05 23.1 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII63878.1 - 6.9e-15 54.9 0.8 1.5e-05 25.2 0.1 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII63878.1 - 8.8e-13 48.1 5.3 3.6e-05 23.7 0.1 3.8 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII63878.1 - 9.2e-08 31.8 6.0 0.062 13.3 0.1 4.1 3 2 1 4 4 4 3 Kelch motif Kelch_5 PF13854.6 KII63878.1 - 3.2e-07 30.2 6.6 0.029 14.3 0.2 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 KII63879.1 - 0.00047 20.3 0.2 0.32 11.4 0.2 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII63879.1 - 0.00083 19.3 0.9 0.0095 15.9 0.4 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 KII63879.1 - 0.015 15.6 0.1 0.059 13.7 0.1 2.1 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 KII63880.1 - 0.048 14.0 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.6 KII63881.1 - 9.4e-27 92.4 7.7 7.3e-09 35.6 0.3 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.25 KII63881.1 - 5.1e-22 77.2 5.2 2.4e-06 27.0 0.0 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 KII63881.1 - 1e-20 73.4 4.5 8.1e-06 25.8 0.0 4.4 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KII63881.1 - 6.6e-17 61.4 2.3 1.7e-05 24.9 0.1 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII63881.1 - 8e-16 57.6 9.3 1.2e-05 25.1 0.2 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 KII63881.1 - 2.1e-10 40.2 7.9 0.0014 18.5 0.2 4.5 4 1 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 KII63883.1 - 0.0041 17.4 0.0 0.014 15.7 0.0 1.9 2 0 0 2 2 2 1 Kelch motif DUF3128 PF11326.8 KII63884.1 - 0.016 15.6 0.1 0.03 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3128) REGB_T4 PF10715.9 KII63884.1 - 0.065 13.4 0.0 0.074 13.3 0.0 1.3 1 0 0 1 1 1 0 T4-page Endoribonuclease RegB Y_phosphatase2 PF03162.13 KII63885.1 - 0.013 15.0 0.1 0.025 14.2 0.0 1.4 2 0 0 2 2 2 0 Tyrosine phosphatase family UvrD-helicase PF00580.21 KII63886.1 - 0.17 11.4 1.0 0.3 10.6 1.0 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain SurA_N_3 PF13624.6 KII63886.1 - 0.2 11.5 1.2 4.5 7.0 0.0 2.6 3 0 0 3 3 3 0 SurA N-terminal domain DUF1548 PF07579.11 KII63888.1 - 0.026 14.8 0.3 0.13 12.6 0.0 2.1 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1548) Nucleo_P87 PF07267.11 KII63891.1 - 0.38 9.5 1.3 0.39 9.5 1.3 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Pkinase_Tyr PF07714.17 KII63892.1 - 2e-27 96.1 0.5 2e-25 89.5 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KII63892.1 - 1.4e-24 86.9 0.6 4.4e-22 78.7 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Bromodomain PF00439.25 KII63893.1 - 1.1e-25 89.4 2.8 4.8e-15 55.4 0.1 5.1 4 1 0 4 4 4 3 Bromodomain HTH_50 PF18024.1 KII63893.1 - 0.086 12.5 0.0 1.2 8.7 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain Whirly PF08536.11 KII63893.1 - 0.1 12.4 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Whirly transcription factor BAH PF01426.18 KII63894.1 - 0.00027 20.8 5.6 0.03 14.2 0.4 2.4 3 0 0 3 3 3 2 BAH domain NAD_binding_5 PF07994.12 KII63896.1 - 3.3e-118 394.8 0.0 3.8e-118 394.5 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 KII63896.1 - 8.9e-43 145.0 0.5 3.1e-42 143.3 0.1 2.1 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase Met_10 PF02475.16 KII63896.1 - 0.067 12.9 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Radical_SAM_C PF16199.5 KII63899.1 - 6.4e-23 80.6 0.2 1.2e-22 79.8 0.2 1.4 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KII63899.1 - 5.2e-18 66.0 0.0 7e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Radical SAM superfamily zf-UBP PF02148.19 KII63900.1 - 0.029 14.7 4.5 0.053 13.9 2.0 2.2 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Kelch_6 PF13964.6 KII63903.1 - 9.6e-13 47.9 4.0 3.1e-05 24.1 0.1 4.2 4 1 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 KII63903.1 - 0.00044 20.5 0.0 0.00044 20.5 0.0 3.0 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII63903.1 - 0.025 14.2 11.0 0.82 9.3 0.8 4.8 4 1 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 KII63903.1 - 0.12 12.4 2.7 1.5 8.9 0.2 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 KII63906.1 - 1.6e-12 47.2 3.4 2.7e-05 24.3 0.0 4.3 2 2 2 4 4 4 3 Kelch motif Kelch_4 PF13418.6 KII63906.1 - 1.1e-10 41.3 2.5 0.0023 17.9 0.1 4.5 3 1 2 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII63906.1 - 4.7e-09 36.3 4.6 1.2e-05 25.4 0.0 4.4 4 1 2 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII63906.1 - 7.3e-07 28.7 7.5 0.02 14.5 0.0 4.6 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 KII63906.1 - 0.056 13.5 3.5 0.42 10.7 0.1 3.5 4 0 0 4 4 4 0 Kelch motif DUF1741 PF08427.10 KII63908.1 - 0.068 12.8 0.1 0.082 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1741) AAA_12 PF13087.6 KII63909.1 - 6e-42 143.5 0.0 6.7e-42 143.4 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KII63909.1 - 0.014 15.2 0.0 0.049 13.5 0.0 1.9 2 1 0 2 2 2 0 UvrD-like helicase C-terminal domain IU_nuc_hydro PF01156.19 KII63911.1 - 7.2e-29 101.3 0.0 8.6e-29 101.1 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Cohesin_HEAT PF12765.7 KII63912.1 - 0.071 13.4 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion RT_RNaseH_2 PF17919.1 KII63913.1 - 2.1e-10 40.5 0.0 3.2e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII63913.1 - 0.058 13.7 0.0 0.091 13.1 0.0 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase SMC_N PF02463.19 KII63914.1 - 3.7e-29 101.7 3.4 1.1e-27 96.9 1.7 3.2 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KII63914.1 - 2e-25 89.4 0.1 1e-24 87.1 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain ATG16 PF08614.11 KII63914.1 - 1.6e-05 25.2 67.6 0.00099 19.4 4.7 5.8 5 1 1 6 6 6 4 Autophagy protein 16 (ATG16) SbcCD_C PF13558.6 KII63914.1 - 0.00068 19.8 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Atg14 PF10186.9 KII63914.1 - 0.0021 17.2 14.6 0.0021 17.2 14.6 4.8 3 2 1 5 5 5 3 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1722 PF08349.11 KII63914.1 - 0.061 13.6 12.3 0.18 12.1 0.9 4.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1722) SMC_N PF02463.19 KII63915.1 - 8e-25 87.6 0.0 8.8e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KII63915.1 - 7.9e-13 49.4 0.0 8.2e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 KII63915.1 - 9.1e-11 42.1 0.0 9.1e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KII63915.1 - 1.3e-08 35.0 0.0 1.3e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KII63915.1 - 6.1e-07 29.1 0.0 8.2e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 KII63915.1 - 0.00045 20.7 0.0 0.00051 20.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 KII63915.1 - 0.0049 17.3 0.0 0.0051 17.2 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain DUF2813 PF11398.8 KII63915.1 - 0.0062 15.8 0.0 0.0062 15.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2813) RNA_helicase PF00910.22 KII63915.1 - 0.0089 16.4 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_27 PF13514.6 KII63915.1 - 0.027 14.1 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.6 KII63915.1 - 0.054 12.5 0.0 0.064 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Mg_chelatase PF01078.21 KII63915.1 - 0.067 12.6 0.0 0.078 12.4 0.0 1.1 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KII63915.1 - 0.073 13.3 0.0 0.091 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 KII63915.1 - 0.081 12.8 0.0 0.096 12.6 0.0 1.1 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_30 PF13604.6 KII63915.1 - 0.093 12.4 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 KII63915.1 - 0.11 12.5 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase PRK PF00485.18 KII63915.1 - 0.13 12.0 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.14 KII63915.1 - 0.13 12.2 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 KII63915.1 - 0.14 12.3 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain Pkinase PF00069.25 KII63916.1 - 1.6e-53 181.8 0.1 2.6e-53 181.1 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII63916.1 - 1.9e-27 96.2 0.0 2.4e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII63916.1 - 0.0019 17.6 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 KII63916.1 - 0.016 14.8 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 KII63916.1 - 0.045 13.1 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII63916.1 - 0.051 13.5 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Reprolysin_2 PF13574.6 KII63917.1 - 0.0065 16.4 2.8 0.0085 16.0 0.5 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 KII63917.1 - 0.01 15.8 0.7 0.023 14.6 0.7 1.6 1 0 0 1 1 1 0 Reprolysin (M12B) family zinc metalloprotease zf-UBR PF02207.20 KII63918.1 - 1e-10 41.6 16.4 2.2e-10 40.6 16.4 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 KII63918.1 - 0.072 13.3 4.4 0.35 11.1 4.4 2.2 1 1 0 1 1 1 0 B-box zinc finger DUF4428 PF14471.6 KII63918.1 - 2 8.4 8.0 43 4.1 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) rve PF00665.26 KII63920.1 - 1.4e-17 63.9 0.0 2.1e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII63920.1 - 0.056 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Uteroglobin PF01099.17 KII63923.1 - 0.48 10.8 4.9 36 4.8 0.3 3.8 4 0 0 4 4 4 0 Uteroglobin family zf-UBR PF02207.20 KII63924.1 - 1e-12 48.0 8.3 1e-12 48.0 8.3 1.5 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) DUF4428 PF14471.6 KII63924.1 - 0.23 11.4 1.9 2.5 8.1 1.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) HTH_32 PF13565.6 KII63926.1 - 0.011 16.3 0.0 0.018 15.6 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Gcd10p PF04189.13 KII63928.1 - 1.1e-30 106.7 0.2 1.5e-30 106.4 0.2 1.2 1 0 0 1 1 1 1 Gcd10p family Serpin PF00079.20 KII63930.1 - 1.4e-50 172.7 1.8 1.6e-50 172.4 1.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) EGF PF00008.27 KII63931.1 - 0.0025 18.1 6.5 0.0025 18.1 6.5 4.6 4 0 0 4 4 4 2 EGF-like domain EGF_2 PF07974.13 KII63931.1 - 0.003 17.9 5.0 0.003 17.9 5.0 4.6 2 2 2 4 4 4 2 EGF-like domain hEGF PF12661.7 KII63931.1 - 7.5 7.3 29.7 0.42 11.3 4.7 4.7 4 1 1 5 5 5 0 Human growth factor-like EGF Ran-binding PF05508.11 KII63932.1 - 9.5e-05 21.5 0.4 0.00014 20.9 0.4 1.1 1 0 0 1 1 1 1 RanGTP-binding protein PCRF PF03462.18 KII63932.1 - 0.088 12.7 0.3 0.14 12.0 0.3 1.2 1 0 0 1 1 1 0 PCRF domain DUF1759 PF03564.15 KII63933.1 - 1.9e-07 31.2 0.0 2.9e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) SWIB PF02201.18 KII63933.1 - 0.036 14.0 0.3 0.13 12.1 0.1 2.0 2 1 1 3 3 3 0 SWIB/MDM2 domain Mtp PF03821.16 KII63935.1 - 0.00045 19.9 0.5 0.00056 19.6 0.5 1.1 1 0 0 1 1 1 1 Golgi 4-transmembrane spanning transporter Epiglycanin_C PF14654.6 KII63935.1 - 0.02 15.0 0.3 0.028 14.5 0.3 1.3 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region Herpes_UL73 PF03554.13 KII63935.1 - 0.14 12.2 1.4 0.27 11.3 1.4 1.4 1 0 0 1 1 1 0 UL73 viral envelope glycoprotein TMEM52 PF14979.6 KII63935.1 - 3 7.8 8.6 10 6.0 3.6 2.2 1 1 1 2 2 2 0 Transmembrane 52 DEAD PF00270.29 KII63936.1 - 1.4e-46 158.5 0.0 3.8e-46 157.1 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII63936.1 - 1.1e-30 106.2 0.0 8.9e-29 100.1 0.1 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.29 KII63936.1 - 2.3e-13 49.7 0.4 5.5e-13 48.6 0.4 1.7 1 0 0 1 1 1 1 KH domain ResIII PF04851.15 KII63936.1 - 0.00065 19.7 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KII63936.1 - 0.0035 16.7 0.6 0.036 13.4 0.0 2.3 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit KH_2 PF07650.17 KII63936.1 - 0.0042 16.9 0.0 0.017 14.9 0.0 2.0 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 KII63936.1 - 0.0061 16.4 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 KH domain RVT_1 PF00078.27 KII63940.1 - 1.5e-19 70.4 0.1 3e-19 69.4 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) HEAT PF02985.22 KII63941.1 - 5e-05 23.2 0.6 1.3 9.5 0.0 5.0 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 KII63941.1 - 0.0037 17.7 0.0 6.8 7.3 0.0 3.9 4 0 0 4 4 4 1 HEAT-like repeat DCB PF16213.5 KII63941.1 - 0.047 13.3 1.2 0.41 10.3 0.1 2.5 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 IFRD PF05004.13 KII63941.1 - 0.094 11.8 0.7 1.4 7.9 0.0 2.6 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) Flavodoxin_NdrI PF07972.11 KII63941.1 - 0.11 12.7 0.2 0.93 9.7 0.2 2.5 2 0 0 2 2 2 0 NrdI Flavodoxin like FKBP_C PF00254.28 KII63942.1 - 9.9e-16 57.8 0.0 2.4e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 KII63942.1 - 5.3e-07 29.2 2.2 0.24 11.3 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII63942.1 - 5.5e-07 29.2 1.3 0.12 12.5 1.5 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KII63942.1 - 9.8e-05 22.5 4.6 0.002 18.3 0.1 3.1 2 1 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KII63942.1 - 0.0011 19.2 0.0 0.4 11.0 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KII63942.1 - 0.0014 19.0 0.2 0.032 14.7 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KII63942.1 - 0.013 15.6 0.5 0.068 13.2 0.0 2.5 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 KII63942.1 - 0.03 14.5 5.7 0.54 10.6 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat CMV_1a PF12467.8 KII63944.1 - 0.028 14.8 0.3 0.098 13.0 0.1 1.7 1 1 0 2 2 2 0 Cucumber mosaic virus 1a protein family DUF3194 PF11419.8 KII63944.1 - 0.083 13.3 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) Kunitz_BPTI PF00014.23 KII63946.1 - 0.017 15.4 5.7 0.025 14.8 5.7 1.3 1 0 0 1 1 1 0 Kunitz/Bovine pancreatic trypsin inhibitor domain IN_DBD_C PF00552.21 KII63949.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Integrase DNA binding domain Glycos_transf_2 PF00535.26 KII63952.1 - 1e-12 48.2 0.1 1.5e-12 47.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 KII63952.1 - 2.2e-05 24.1 0.1 4.9e-05 22.9 0.1 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 DUF2711 PF10924.8 KII63952.1 - 0.021 14.4 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2711) ADK PF00406.22 KII63953.1 - 6e-13 49.2 0.0 6.9e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KII63953.1 - 1.9e-07 31.6 0.0 2.2e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain EVI2A PF05399.11 KII63954.1 - 3.1e-05 23.7 6.6 3.6e-05 23.5 6.6 1.0 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) LAP1C PF05609.12 KII63954.1 - 0.0015 17.7 2.0 0.0018 17.5 2.0 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) DUF1180 PF06679.12 KII63954.1 - 0.0018 18.7 0.6 0.0025 18.2 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) RIFIN PF02009.16 KII63954.1 - 0.0024 17.8 1.5 0.0028 17.6 1.5 1.1 1 0 0 1 1 1 1 Rifin TMEM154 PF15102.6 KII63954.1 - 0.0041 17.0 15.5 0.021 14.8 15.5 1.9 1 1 0 1 1 1 1 TMEM154 protein family DUF3112 PF11309.8 KII63954.1 - 0.037 13.5 0.8 0.044 13.2 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Plasmodium_Vir PF05795.11 KII63954.1 - 0.039 13.4 4.2 0.044 13.2 4.2 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein BBS2_N PF14781.6 KII63954.1 - 0.047 13.6 1.6 0.076 12.9 1.6 1.5 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal MHYT PF03707.16 KII63954.1 - 0.051 13.7 0.5 0.082 13.1 0.5 1.2 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat AJAP1_PANP_C PF15298.6 KII63954.1 - 0.063 13.5 5.9 0.077 13.2 5.9 1.1 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Orf78 PF06024.12 KII63954.1 - 1.1 9.6 5.7 5.5 7.3 5.7 1.9 1 1 0 1 1 1 0 Orf78 (ac78) Kei1 PF08552.11 KII63954.1 - 2.8 7.8 6.8 4.5 7.1 6.8 1.4 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Shisa PF13908.6 KII63954.1 - 7.4 6.8 9.4 11 6.1 8.7 1.7 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator CssAB PF16831.5 KII63955.1 - 0.14 12.5 0.0 8.9 6.7 0.0 2.1 2 0 0 2 2 2 0 CS6 fimbrial subunits A and B, Coli surface antigen 6 Pkinase PF00069.25 KII63958.1 - 8.1e-32 110.6 0.2 1.2e-31 110.0 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII63958.1 - 1.2e-13 51.0 0.1 1.5e-13 50.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Synaptobrevin PF00957.21 KII63959.1 - 0.01 15.6 0.4 0.022 14.5 0.4 1.6 1 0 0 1 1 1 0 Synaptobrevin Focal_AT PF03623.13 KII63959.1 - 0.091 12.8 1.4 0.23 11.4 0.5 2.0 2 0 0 2 2 2 0 Focal adhesion targeting region SlyX PF04102.12 KII63959.1 - 0.13 12.9 0.5 0.37 11.4 0.5 1.8 1 0 0 1 1 1 0 SlyX DUF1664 PF07889.12 KII63959.1 - 0.34 10.9 2.9 2.4 8.2 0.0 3.0 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) SNARE PF05739.19 KII63959.1 - 0.5 10.4 8.3 1.3 9.1 6.9 2.4 1 1 1 2 2 2 0 SNARE domain LXG PF04740.12 KII63959.1 - 0.51 10.0 3.2 0.38 10.4 1.2 1.8 1 1 1 2 2 2 0 LXG domain of WXG superfamily IMPDH PF00478.25 KII63960.1 - 0.00011 21.4 0.0 0.00013 21.1 0.0 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain IMPDH PF00478.25 KII63961.1 - 9.1e-53 179.5 4.3 1.2e-52 179.1 4.3 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KII63961.1 - 8.4e-05 21.8 0.8 0.00013 21.1 0.8 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase gag-asp_proteas PF13975.6 KII63964.1 - 0.0021 18.6 0.0 0.003 18.1 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII63964.1 - 0.0021 18.6 0.1 0.0029 18.2 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease Lgl_C PF08596.10 KII63964.1 - 0.049 12.3 0.1 0.054 12.2 0.1 1.1 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal DnaGprimase_HBD PF16730.5 KII63965.1 - 0.014 15.5 0.2 0.028 14.5 0.2 1.6 1 1 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain MULE PF10551.9 KII63966.1 - 1e-05 25.9 0.1 6.7e-05 23.2 0.1 2.1 1 1 0 1 1 1 1 MULE transposase domain DUF1676 PF07898.13 KII63968.1 - 0.021 14.9 0.1 0.044 13.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DUF1676 PF07898.13 KII63969.1 - 0.0059 16.7 0.0 0.015 15.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1676) zf-UBR PF02207.20 KII63970.1 - 5.7e-13 48.8 19.8 1.1e-12 47.9 19.8 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) FemAB_like PF04339.12 KII63971.1 - 0.024 13.8 0.1 0.038 13.1 0.1 1.3 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition B2 PF11473.8 KII63972.1 - 0.027 14.2 0.1 0.47 10.3 0.0 2.1 1 1 1 2 2 2 0 RNA binding protein B2 BioT2 PF15368.6 KII63972.1 - 0.071 13.1 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 Spermatogenesis family BioT2 BEN PF10523.9 KII63972.1 - 0.11 12.7 0.1 2.1 8.6 0.0 2.2 1 1 0 2 2 2 0 BEN domain Glycos_transf_2 PF00535.26 KII63974.1 - 2.1e-29 102.5 0.0 3.7e-29 101.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KII63974.1 - 2.5e-12 47.1 10.8 4.4e-12 46.4 10.8 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 KII63974.1 - 1.4e-05 24.6 0.1 6.2e-05 22.6 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KII63974.1 - 0.0028 17.2 0.0 0.011 15.2 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 CDtoxinA PF03498.14 KII63974.1 - 0.0069 16.0 6.4 0.012 15.2 2.1 2.3 1 1 1 2 2 2 1 Cytolethal distending toxin A/C domain LANC_like PF05147.13 KII63975.1 - 0.026 13.1 0.3 0.061 11.9 0.2 1.4 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein DUF2052 PF09747.9 KII63976.1 - 1e-17 64.9 10.7 1.5e-08 35.0 2.6 2.3 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Xpo1 PF08389.12 KII63977.1 - 0.0067 16.5 0.3 0.042 13.9 0.0 2.1 2 1 0 2 2 2 1 Exportin 1-like protein U62_UL91 PF17442.2 KII63977.1 - 0.014 15.4 0.2 2.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Functional domain of U62 and UL91 proteins IBN_N PF03810.19 KII63977.1 - 0.04 13.8 2.8 0.17 11.8 0.5 2.5 2 1 1 3 3 3 0 Importin-beta N-terminal domain Dynein_AAA_lid PF17852.1 KII63978.1 - 0.12 12.5 5.6 0.73 9.9 0.0 4.3 4 1 1 5 5 5 0 Dynein heavy chain AAA lid domain DDE_3 PF13358.6 KII63979.1 - 6e-06 26.1 0.1 1e-05 25.3 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease CRIC_ras_sig PF10534.9 KII63979.1 - 0.079 13.1 0.0 0.17 12.1 0.0 1.6 1 1 0 1 1 1 0 Connector enhancer of kinase suppressor of ras Sec8_exocyst PF04048.14 KII63980.1 - 0.2 11.5 0.1 0.28 11.1 0.1 1.1 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Adipogenin PF15202.6 KII63982.1 - 0.015 15.3 0.2 0.026 14.5 0.2 1.4 1 0 0 1 1 1 0 Adipogenin rve PF00665.26 KII63983.1 - 2.7e-13 50.1 0.0 3.9e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII63983.1 - 6.3e-05 22.7 0.1 0.00014 21.6 0.1 1.6 1 1 0 1 1 1 1 Integrase core domain Ribonuc_L-PSP PF01042.21 KII63984.1 - 5.1e-33 113.6 0.0 5.8e-33 113.5 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP YcxB PF14317.6 KII63986.1 - 0.089 12.5 0.2 1.2 8.9 0.1 2.2 2 0 0 2 2 2 0 YcxB-like protein DUF268 PF03269.14 KII63986.1 - 0.14 12.0 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF268 Ssu72 PF04722.13 KII63988.1 - 1.9e-10 40.6 0.1 9.5e-10 38.4 0.1 1.9 1 1 0 1 1 1 1 Ssu72-like protein Trp_Tyr_perm PF03222.13 KII63991.1 - 2.6e-05 23.5 9.3 3.7e-05 22.9 9.1 1.4 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family DUF373 PF04123.13 KII63991.1 - 0.43 10.0 5.1 0.57 9.6 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) RNA_pol_Rpb4 PF03874.16 KII63993.1 - 2.9e-17 63.1 2.8 3.9e-17 62.7 2.8 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 MIF4G_like_2 PF09090.11 KII63993.1 - 0.033 13.7 1.5 0.059 12.8 0.3 1.9 1 1 1 2 2 2 0 MIF4G like PNPase PF03726.14 KII63993.1 - 1.2 9.7 3.9 18 5.9 3.2 2.7 1 1 1 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain MULE PF10551.9 KII63994.1 - 4.7e-05 23.7 0.2 0.0015 18.9 0.0 2.8 2 1 1 3 3 3 1 MULE transposase domain H_lectin PF09458.10 KII63994.1 - 0.071 13.3 0.4 0.15 12.3 0.2 1.7 2 0 0 2 2 2 0 H-type lectin domain Nore1-SARAH PF16517.5 KII63995.1 - 0.47 10.4 2.9 1.1 9.3 1.2 2.3 1 1 1 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Rotamase_3 PF13616.6 KII63996.1 - 3.7e-20 72.6 0.3 1.5e-19 70.7 0.3 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 KII63996.1 - 1e-17 64.9 0.2 3.6e-17 63.1 0.2 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KII63996.1 - 3.4e-05 24.7 0.0 6.7e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain Imm5 PF14423.6 KII63997.1 - 0.043 14.0 0.1 0.057 13.6 0.1 1.1 1 0 0 1 1 1 0 Immunity protein Imm5 Alpha_adaptin_C PF02296.16 KII63997.1 - 0.05 13.8 0.0 0.11 12.7 0.0 1.6 2 0 0 2 2 2 0 Alpha adaptin AP2, C-terminal domain Transposase_mut PF00872.18 KII63998.1 - 0.029 13.2 1.4 0.034 13.0 1.4 1.2 1 0 0 1 1 1 0 Transposase, Mutator family DDE_1 PF03184.19 KII64002.1 - 5.9e-15 55.4 0.2 1.2e-14 54.3 0.2 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII64002.1 - 1.6e-11 44.0 0.1 4.1e-11 42.8 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain eIF-1a PF01176.19 KII64004.1 - 5.1e-17 61.4 0.0 7.8e-17 60.8 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 COX5A PF02284.16 KII64005.1 - 1.4e-14 54.0 0.0 1.7e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DDE_Tnp_IS1595 PF12762.7 KII64006.1 - 9.2e-10 38.7 0.0 1.5e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.14 KII64006.1 - 2.7e-05 23.8 0.0 4.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Transposase IS66 family zf-TFIIB PF13453.6 KII64006.1 - 0.012 15.0 1.1 0.021 14.1 1.1 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger Ta0938 PF11494.8 KII64006.1 - 0.049 13.9 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Ta0938 YdjO PF14169.6 KII64006.1 - 0.69 9.7 3.8 16 5.3 0.3 2.4 1 1 1 2 2 2 0 Cold-inducible protein YdjO DDE_Tnp_IS1595 PF12762.7 KII64007.1 - 1.7e-06 28.1 0.0 3.3e-06 27.2 0.0 1.5 2 0 0 2 2 2 1 ISXO2-like transposase domain BRCT_2 PF16589.5 KII64007.1 - 0.026 14.9 0.3 0.072 13.5 0.3 1.9 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Ish1 PF10281.9 KII64007.1 - 0.063 13.6 0.0 0.28 11.5 0.0 2.1 1 1 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Nucleoside_tran PF01733.18 KII64013.1 - 7.6e-20 71.5 4.9 8.4e-20 71.4 4.9 1.0 1 0 0 1 1 1 1 Nucleoside transporter Imm43 PF15570.6 KII64013.1 - 0.061 13.3 0.2 0.088 12.8 0.2 1.3 1 1 0 1 1 1 0 Immunity protein 43 DUF4933 PF16287.5 KII64013.1 - 0.072 12.5 0.0 0.082 12.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4933) Ldl_recept_a PF00057.18 KII64014.1 - 2.4e-51 171.7 129.6 2.2e-11 43.8 10.4 8.2 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII64014.1 - 2.2e-17 63.0 0.0 4.6e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII64014.1 - 5.4e-17 62.7 3.3 5.4e-17 62.7 3.3 4.0 2 1 1 3 3 3 1 Sortilin, neurotensin receptor 3, C-terminal PDR_CDR PF06422.12 KII64014.1 - 0.064 13.2 1.0 0.18 11.7 1.0 1.8 1 0 0 1 1 1 0 CDR ABC transporter BNR_6 PF15899.5 KII64014.1 - 0.76 10.0 2.9 1.2 9.4 0.5 2.5 2 0 0 2 2 2 0 BNR-Asp box repeat BNR PF02012.20 KII64014.1 - 2.4 8.5 6.0 48 4.6 0.7 3.7 3 0 0 3 3 3 0 BNR/Asp-box repeat Glyco_hydro_15 PF00723.21 KII64016.1 - 5e-19 68.4 0.0 5.9e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Glyco_hydro_15 PF00723.21 KII64017.1 - 1.1e-80 271.7 0.0 1.4e-80 271.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 APOBEC1 PF18769.1 KII64018.1 - 0.045 14.0 0.1 0.06 13.6 0.1 1.3 1 0 0 1 1 1 0 APOBEC1 SGT1 PF07093.11 KII64019.1 - 3.9e-32 111.5 13.6 5.8e-30 104.3 4.0 3.3 1 1 1 2 2 2 2 SGT1 protein KTI12 PF08433.10 KII64019.1 - 0.044 13.2 0.1 0.08 12.4 0.1 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 sCache_like PF16736.5 KII64019.1 - 0.1 12.7 0.4 15 5.7 0.0 2.9 3 0 0 3 3 3 0 Single Cache-like EF1G PF00647.19 KII64019.1 - 0.16 12.0 2.2 1.5 8.9 0.1 2.8 2 0 0 2 2 2 0 Elongation factor 1 gamma, conserved domain DUF3338 PF11819.8 KII64020.1 - 0.079 12.9 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3338) Sortilin-Vps10 PF15902.5 KII64021.1 - 4e-08 32.5 2.4 0.00055 18.8 0.2 2.4 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII64021.1 - 0.00016 21.2 3.4 0.24 11.5 0.2 2.9 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_6 PF15899.5 KII64021.1 - 0.0016 18.3 3.9 0.68 10.2 0.5 3.2 3 0 0 3 3 3 2 BNR-Asp box repeat CE2_N PF17996.1 KII64021.1 - 0.16 12.0 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal DUF2340 PF10209.9 KII64023.1 - 0.0022 18.4 0.4 0.0027 18.1 0.4 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) DUF4835 PF16119.5 KII64023.1 - 0.0072 15.5 0.5 0.0081 15.3 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4835) DUF1204 PF06721.11 KII64023.1 - 0.014 14.9 0.1 0.027 13.9 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1204) GCV_H PF01597.19 KII64023.1 - 0.018 14.9 0.2 0.023 14.6 0.2 1.2 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF3209 PF11483.8 KII64023.1 - 0.066 13.7 0.1 0.084 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) SNAP PF14938.6 KII64024.1 - 1.9e-06 27.5 4.1 2.9e-06 26.9 4.1 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Borrelia_lipo_1 PF05714.11 KII64025.1 - 0.0058 16.4 0.5 0.019 14.7 0.2 2.0 2 0 0 2 2 2 1 Borrelia burgdorferi virulent strain associated lipoprotein Tho2 PF11262.8 KII64025.1 - 0.012 14.8 0.2 0.69 9.1 0.1 2.4 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 NikR_C PF08753.11 KII64025.1 - 0.094 12.9 0.2 0.21 11.8 0.2 1.6 1 0 0 1 1 1 0 NikR C terminal nickel binding domain rve_3 PF13683.6 KII64026.1 - 0.00029 20.5 0.0 0.00067 19.4 0.0 1.7 1 1 0 1 1 1 1 Integrase core domain rve PF00665.26 KII64026.1 - 0.0024 18.1 0.0 0.0041 17.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_12 PF18658.1 KII64026.1 - 0.17 11.5 0.1 0.9 9.2 0.0 2.0 2 0 0 2 2 2 0 Zinc-finger C2H2-type FANCI_S2 PF14676.6 KII64027.1 - 0.015 15.6 1.3 8 6.7 0.0 3.5 3 0 0 3 3 3 0 FANCI solenoid 2 DUF725 PF05267.12 KII64027.1 - 0.049 13.6 0.1 0.31 11.0 0.0 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF725) DUF4577 PF15145.6 KII64030.1 - 0.069 13.2 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) Tmemb_9 PF05434.11 KII64030.1 - 2.3 8.1 9.3 0.81 9.6 6.4 1.7 1 1 1 2 2 2 0 TMEM9 DUF1682 PF07946.14 KII64031.1 - 0.031 13.5 0.3 0.031 13.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) UXS1_N PF11803.8 KII64031.1 - 0.061 13.7 0.1 0.083 13.3 0.1 1.2 1 0 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal Sortilin-Vps10 PF15902.5 KII64032.1 - 1.6e-07 30.5 0.4 0.0019 17.1 0.1 2.0 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII64032.1 - 0.00041 19.9 0.2 1.5 9.1 0.0 2.6 2 0 0 2 2 2 2 BNR/Asp-box repeat DDE_Tnp_IS1595 PF12762.7 KII64033.1 - 0.014 15.4 1.1 0.018 15.1 1.1 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain Ldl_recept_a PF00057.18 KII64036.1 - 4.1e-10 39.7 25.1 2.3e-07 30.9 8.0 2.5 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A SNAP PF14938.6 KII64037.1 - 0.0014 18.1 0.2 0.0015 18.0 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP E1_DerP2_DerF2 PF02221.15 KII64039.1 - 0.0047 17.4 0.1 0.0064 16.9 0.1 1.2 1 0 0 1 1 1 1 ML domain Glyco_transf_8C PF08437.10 KII64040.1 - 0.18 11.9 0.1 0.29 11.2 0.1 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 8 C-terminal Got1 PF04178.12 KII64041.1 - 5.5e-28 97.6 14.4 7.5e-28 97.2 14.4 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family PGG PF13962.6 KII64041.1 - 0.0036 17.1 11.0 0.15 11.9 2.5 2.4 1 1 1 2 2 2 2 Domain of unknown function DUF3566 PF12089.8 KII64041.1 - 0.13 12.6 9.6 0.19 12.1 9.6 1.4 1 1 0 1 1 1 0 Transmembrane domain of unknown function (DUF3566) DUF2070 PF09843.9 KII64041.1 - 2.7 6.2 10.3 3.1 6.0 10.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF3040 PF11239.8 KII64041.1 - 2.9 8.2 9.2 8.6 6.7 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DDE_3 PF13358.6 KII64042.1 - 0.0043 16.8 0.0 0.0077 16.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Sortilin_C PF15901.5 KII64045.1 - 2.3e-10 41.1 1.8 3.8e-10 40.4 1.8 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII64045.1 - 1.2e-06 27.6 3.1 6e-06 25.3 3.1 1.9 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII64045.1 - 0.0037 17.0 8.9 0.34 11.1 0.1 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat Serpin PF00079.20 KII64047.1 - 2.9e-17 63.0 0.4 3.4e-17 62.8 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.6 KII64048.1 - 0.012 15.1 0.1 0.013 15.0 0.1 1.2 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP Rep_trans PF02486.19 KII64049.1 - 0.021 14.5 0.0 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 Replication initiation factor Ndc80_HEC PF03801.13 KII64049.1 - 0.17 11.5 1.9 0.19 11.3 0.7 1.8 2 0 0 2 2 2 0 HEC/Ndc80p family Astro_capsid_p PF12226.8 KII64050.1 - 0.13 11.3 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Asp_protease_2 PF13650.6 KII64051.1 - 8.9e-05 23.1 0.0 0.00018 22.1 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII64051.1 - 0.00071 20.1 0.1 0.0028 18.2 0.0 2.0 1 1 1 2 2 2 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII64051.1 - 0.037 14.3 0.0 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease DUF325 PF03804.13 KII64051.1 - 0.19 11.8 1.3 33 4.6 0.0 4.1 5 0 0 5 5 5 0 Viral proteins of unknown function S6OS1 PF15676.5 KII64051.1 - 0.35 9.3 2.5 1.9 6.9 0.2 2.1 2 0 0 2 2 2 0 Six6 opposite strand transcript 1 family Glyco_tran_10_N PF17039.5 KII64051.1 - 1.2 9.6 3.8 16 6.0 0.1 2.7 2 1 0 2 2 2 0 Fucosyltransferase, N-terminal Serpin PF00079.20 KII64052.1 - 1.6e-37 129.8 1.3 1.8e-37 129.6 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII64053.1 - 1.2e-24 87.3 0.9 1.5e-24 87.0 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Lon_2 PF13337.6 KII64053.1 - 0.031 12.8 0.1 0.088 11.3 0.0 1.7 2 0 0 2 2 2 0 Putative ATP-dependent Lon protease Serpin PF00079.20 KII64056.1 - 1.2e-25 90.6 0.4 1.4e-25 90.4 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII64057.1 - 9.6e-20 71.2 2.7 1.1e-19 71.0 2.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RuBisCO_small PF00101.20 KII64057.1 - 0.2 11.7 1.3 0.37 10.8 0.3 1.8 2 0 0 2 2 2 0 Ribulose bisphosphate carboxylase, small chain Serpin PF00079.20 KII64058.1 - 2.3e-48 165.4 2.4 2.6e-48 165.2 2.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Arylsulfotran_2 PF14269.6 KII64058.1 - 0.017 14.5 0.2 0.085 12.2 0.0 1.9 2 0 0 2 2 2 0 Arylsulfotransferase (ASST) RIFIN PF02009.16 KII64060.1 - 0.0091 15.9 0.1 0.019 14.8 0.0 1.7 2 0 0 2 2 2 1 Rifin PCMT PF01135.19 KII64063.1 - 1.1e-19 71.1 0.0 1.3e-19 70.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KII64063.1 - 0.001 18.9 0.0 0.0013 18.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KII64063.1 - 0.0029 17.1 0.0 0.0042 16.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.6 KII64063.1 - 0.0053 16.8 0.0 0.0065 16.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII64063.1 - 0.01 15.7 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 KII64063.1 - 0.19 11.5 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 Lysine methyltransferase RT_RNaseH_2 PF17919.1 KII64066.1 - 1.6e-39 134.0 0.0 4e-39 132.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64066.1 - 7.1e-36 122.7 0.1 2.2e-35 121.1 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64066.1 - 4.1e-31 108.2 0.5 1e-30 106.9 0.5 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII64066.1 - 8.3e-18 64.7 0.0 1.7e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64066.1 - 1.2e-16 60.6 0.4 2.9e-16 59.3 0.4 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII64066.1 - 5.7e-06 26.8 0.0 3.3e-05 24.4 0.0 2.3 3 0 0 3 3 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII64066.1 - 3.6e-05 23.6 3.9 0.00011 22.0 3.9 1.9 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 KII64066.1 - 0.00036 21.1 0.1 0.0018 18.9 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-H2C2 PF09337.10 KII64066.1 - 0.00061 20.0 0.4 0.002 18.3 0.4 2.0 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII64066.1 - 0.012 15.4 0.1 0.1 12.4 0.0 2.7 2 0 0 2 2 2 0 Integrase core domain zf-CCHC_4 PF14392.6 KII64066.1 - 0.014 15.1 1.3 0.059 13.1 1.3 2.1 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII64066.1 - 0.02 15.0 0.0 0.052 13.7 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP PF00077.20 KII64066.1 - 0.055 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease HV_small_capsid PF17086.5 KII64068.1 - 0.13 12.5 0.0 0.32 11.3 0.0 1.6 1 1 1 2 2 2 0 Small capsid protein of Herpesviridae DUF2652 PF10851.8 KII64069.1 - 0.0049 17.0 1.0 0.0083 16.2 0.6 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2652) DUF366 PF04017.12 KII64072.1 - 0.11 12.0 0.1 0.14 11.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF366) RVT_1 PF00078.27 KII64073.1 - 0.015 14.8 0.1 0.034 13.7 0.1 1.5 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) FAM92 PF06730.11 KII64073.1 - 0.11 11.9 0.4 0.14 11.5 0.4 1.1 1 0 0 1 1 1 0 FAM92 protein Xpo1 PF08389.12 KII64074.1 - 0.0069 16.5 1.2 0.7 9.9 0.2 2.0 1 1 1 2 2 2 2 Exportin 1-like protein FlgN PF05130.12 KII64075.1 - 0.045 14.3 0.7 0.062 13.8 0.7 1.1 1 0 0 1 1 1 0 FlgN protein DUF1911 PF08929.10 KII64075.1 - 0.11 13.4 0.3 0.16 12.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) Intron_maturas2 PF01348.21 KII64077.1 - 0.071 13.1 0.0 0.17 11.8 0.0 1.6 2 0 0 2 2 2 0 Type II intron maturase DUF3800 PF12686.7 KII64083.1 - 3.3e-08 34.2 0.0 6.6e-08 33.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3800) Phage_int_SAM_4 PF13495.6 KII64085.1 - 0.027 14.9 0.0 0.044 14.3 0.0 1.3 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain RelB_N PF18506.1 KII64086.1 - 0.15 11.9 0.6 0.23 11.3 0.0 1.6 2 0 0 2 2 2 0 RelB Antitoxin alpha helical domain HTH_Tnp_Tc5 PF03221.16 KII64087.1 - 1e-10 41.5 0.1 2e-10 40.5 0.0 1.5 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Arena_ncap_C PF17290.2 KII64087.1 - 0.12 11.7 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Arenavirus nucleocapsid C-terminal domain B3R PF17057.5 KII64088.1 - 0.21 11.8 0.1 5 7.4 0.0 2.1 2 0 0 2 2 2 0 Poxviridae B3 protein MULE PF10551.9 KII64089.1 - 2.1e-07 31.3 0.1 6.8e-07 29.6 0.2 1.7 2 0 0 2 2 2 1 MULE transposase domain Sedlin_N PF04628.13 KII64092.1 - 0.041 14.0 0.1 0.05 13.7 0.1 1.1 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region V-ATPase_C PF03223.15 KII64093.1 - 3.7e-99 332.6 9.8 4.1e-99 332.5 9.8 1.0 1 0 0 1 1 1 1 V-ATPase subunit C NOG1_N PF17835.1 KII64093.1 - 0.0082 16.1 0.7 0.015 15.2 0.1 1.6 2 0 0 2 2 2 1 NOG1 N-terminal helical domain Sipho_Gp157 PF05565.11 KII64093.1 - 0.021 14.9 0.2 0.021 14.9 0.2 2.0 3 0 0 3 3 3 0 Siphovirus Gp157 MetW PF07021.12 KII64093.1 - 0.021 14.4 0.3 0.037 13.6 0.3 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW FAM176 PF14851.6 KII64094.1 - 0.0069 16.0 0.1 0.0094 15.6 0.1 1.3 1 0 0 1 1 1 1 FAM176 family OAD_gamma PF04277.13 KII64094.1 - 0.38 11.4 7.9 6.1 7.5 7.9 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain MCLC PF05934.11 KII64100.1 - 1.7e-07 30.4 1.5 2.2e-07 30.0 1.5 1.1 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) GNT-I PF03071.15 KII64101.1 - 2.2e-77 260.7 0.9 2.6e-77 260.4 0.9 1.0 1 0 0 1 1 1 1 GNT-I family TMEM154 PF15102.6 KII64101.1 - 0.19 11.7 1.4 0.6 10.0 0.6 2.0 2 0 0 2 2 2 0 TMEM154 protein family RVT_1 PF00078.27 KII64102.1 - 1.2e-07 31.5 0.0 1.4e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MLVIN_C PF18697.1 KII64103.1 - 0.008 16.3 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Shugoshin_C PF07557.11 KII64103.1 - 0.017 14.9 0.1 0.029 14.1 0.1 1.4 1 0 0 1 1 1 0 Shugoshin C terminus SH3_11 PF18103.1 KII64104.1 - 0.00019 21.5 0.0 0.0004 20.5 0.0 1.5 1 0 0 1 1 1 1 Retroviral integrase C-terminal SH3 domain MLVIN_C PF18697.1 KII64104.1 - 0.029 14.4 0.8 0.049 13.7 0.8 1.4 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Bac_export_3 PF01313.19 KII64105.1 - 0.054 13.4 0.5 0.1 12.5 0.2 1.6 2 0 0 2 2 2 0 Bacterial export proteins, family 3 COX2_TM PF02790.15 KII64105.1 - 0.11 12.7 2.5 0.38 10.9 0.3 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain GNT-I PF03071.15 KII64106.1 - 2.7e-12 46.2 0.1 3.5e-12 45.8 0.1 1.1 1 0 0 1 1 1 1 GNT-I family FtsH_ext PF06480.15 KII64106.1 - 0.015 15.7 0.3 0.018 15.4 0.3 1.3 1 1 0 1 1 1 0 FtsH Extracellular DTC PF18102.1 KII64106.1 - 0.075 13.2 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Deltex C-terminal domain ETRAMP PF09716.10 KII64106.1 - 0.096 12.8 2.3 0.19 11.8 2.1 1.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) GNT-I PF03071.15 KII64107.1 - 1.7e-34 119.4 0.2 1.9e-34 119.2 0.2 1.0 1 0 0 1 1 1 1 GNT-I family EC042_2821 PF18740.1 KII64108.1 - 0.025 14.4 0.6 0.031 14.2 0.6 1.1 1 0 0 1 1 1 0 EC042_2821-lke REase RT_RNaseH_2 PF17919.1 KII64110.1 - 7.5e-16 58.0 0.1 1.4e-15 57.2 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64110.1 - 2.3e-13 50.3 0.7 3.4e-13 49.8 0.1 1.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII64110.1 - 0.0012 18.9 0.2 0.0031 17.6 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain XisI PF08869.11 KII64110.1 - 0.048 14.0 0.3 0.074 13.4 0.3 1.4 1 0 0 1 1 1 0 XisI protein Pox_L5 PF04872.13 KII64110.1 - 0.096 12.6 0.1 1 9.3 0.0 2.3 2 0 0 2 2 2 0 Poxvirus L5 protein family Rota_NSP4 PF01452.16 KII64113.1 - 0.012 15.3 2.6 0.013 15.1 2.6 1.2 1 0 0 1 1 1 0 Rotavirus non structural protein DUF932 PF06067.11 KII64113.1 - 0.036 13.8 1.2 0.042 13.6 1.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF932) Toprim_Crpt PF13342.6 KII64113.1 - 0.06 13.3 0.6 0.11 12.4 0.6 1.5 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase DUF3160 PF11369.8 KII64113.1 - 0.062 11.8 2.2 0.054 12.0 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3160) B5 PF03484.15 KII64113.1 - 0.14 12.4 0.8 2.7 8.3 0.8 2.2 1 1 0 1 1 1 0 tRNA synthetase B5 domain PRD PF00874.20 KII64113.1 - 2.3 8.6 9.0 2 8.7 6.1 1.9 1 1 1 2 2 2 0 PRD domain gag-asp_proteas PF13975.6 KII64114.1 - 0.00023 21.7 0.0 0.00052 20.5 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII64114.1 - 0.00074 20.1 0.0 0.0019 18.8 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII64114.1 - 0.0017 18.4 2.1 0.0017 18.4 2.1 2.5 2 0 0 2 2 2 1 Zinc knuckle Asp_protease PF09668.10 KII64114.1 - 0.021 14.6 0.1 0.085 12.6 0.1 2.0 1 1 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII64114.1 - 0.12 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF4201 PF13870.6 KII64115.1 - 0.075 12.8 9.6 0.11 12.2 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) BRE1 PF08647.11 KII64115.1 - 2.4 8.3 10.7 2.1 8.5 9.1 1.7 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase ZapB PF06005.12 KII64115.1 - 9.9 6.7 11.7 0.11 12.9 2.7 2.2 3 0 0 3 3 3 0 Cell division protein ZapB CAP18_C PF12153.8 KII64117.1 - 0.0012 18.7 0.4 0.0029 17.4 0.1 1.8 2 0 0 2 2 2 1 LPS binding domain of CAP18 (C terminal) IFT46_B_C PF12317.8 KII64117.1 - 0.0038 17.0 0.3 0.0087 15.8 0.1 1.6 1 1 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal Baculo_PEP_C PF04513.12 KII64117.1 - 0.015 15.3 0.2 0.02 14.9 0.2 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Noelin-1 PF12308.8 KII64117.1 - 0.018 15.0 0.4 0.04 13.9 0.4 1.6 1 0 0 1 1 1 0 Neurogenesis glycoprotein DUF1664 PF07889.12 KII64117.1 - 0.046 13.8 0.5 0.046 13.8 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 KII64117.1 - 0.054 13.7 9.1 0.23 11.7 2.3 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF416 PF04222.12 KII64117.1 - 0.056 12.9 5.5 0.033 13.6 2.1 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF416) Phage_GPO PF05929.11 KII64117.1 - 0.061 12.9 5.7 0.078 12.6 5.7 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase XhlA PF10779.9 KII64117.1 - 0.16 12.2 2.2 0.4 10.9 2.2 1.6 1 0 0 1 1 1 0 Haemolysin XhlA DUF4709 PF15821.5 KII64117.1 - 0.34 11.2 6.5 0.28 11.5 4.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4709) CREPT PF16566.5 KII64117.1 - 0.44 10.7 6.8 0.37 11.0 1.1 2.3 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour CENP-F_leu_zip PF10473.9 KII64117.1 - 2.6 8.1 12.2 65 3.5 12.2 2.2 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.11 KII64117.1 - 5.9 7.2 6.9 2.6 8.4 0.5 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 KII64117.1 - 7.6 7.0 7.8 3.3 8.2 1.6 3.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF2098 PF09871.9 KII64117.1 - 8.3 6.8 7.6 1.2 9.5 1.7 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) DUF3148 PF11347.8 KII64118.1 - 0.0041 16.9 0.0 0.0064 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3148) CxC5 PF18718.1 KII64122.1 - 0.0035 17.4 0.3 0.0046 17.0 0.3 1.1 1 0 0 1 1 1 1 CxC5 like cysteine cluster associated with KDZ transposases Gin PF10764.9 KII64122.1 - 0.02 14.9 1.6 0.44 10.6 0.1 2.4 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin zf_UBZ PF18439.1 KII64122.1 - 0.022 14.3 3.0 1.8 8.2 0.5 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF2039 PF10217.9 KII64122.1 - 0.023 15.0 0.5 0.94 9.9 0.0 2.1 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) HNH_5 PF14279.6 KII64122.1 - 0.051 13.4 1.2 3.9 7.4 0.2 2.3 2 0 0 2 2 2 0 HNH endonuclease zf-B_box PF00643.24 KII64122.1 - 0.16 12.2 2.6 4.5 7.5 0.3 2.5 2 0 0 2 2 2 0 B-box zinc finger Peptidase_S46 PF10459.9 KII64123.1 - 0.00079 18.2 7.1 0.0008 18.2 7.1 1.1 1 0 0 1 1 1 1 Peptidase S46 DUF382 PF04037.13 KII64123.1 - 0.038 14.1 10.0 0.1 12.8 2.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF382) UvsW PF11637.8 KII64123.1 - 0.053 13.6 0.5 0.34 11.0 0.2 2.5 3 1 0 3 3 3 0 ATP-dependant DNA helicase UvsW DUF4407 PF14362.6 KII64123.1 - 3.1 7.0 6.1 3.8 6.8 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 KII64125.1 - 2.2e-06 28.3 6.4 2.9e-06 27.9 6.4 1.1 1 0 0 1 1 1 1 Fez1 Wx5_PLAF3D7 PF09688.10 KII64125.1 - 0.0039 17.2 6.9 0.037 14.0 0.8 2.0 2 0 0 2 2 2 1 Protein of unknown function (Wx5_PLAF3D7) PBP_dimer PF03717.15 KII64125.1 - 0.0081 16.5 4.3 0.0093 16.3 1.3 2.0 1 1 1 2 2 2 1 Penicillin-binding Protein dimerisation domain Macoilin PF09726.9 KII64125.1 - 0.014 14.0 6.2 0.017 13.7 6.2 1.0 1 0 0 1 1 1 0 Macoilin family BLOC1_2 PF10046.9 KII64125.1 - 0.022 15.1 8.2 0.61 10.4 1.1 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATG16 PF08614.11 KII64125.1 - 0.028 14.7 8.7 0.055 13.7 8.7 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Exonuc_VII_L PF02601.15 KII64125.1 - 0.035 13.7 3.2 0.044 13.3 3.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tropomyosin_1 PF12718.7 KII64125.1 - 0.038 14.1 10.7 0.18 11.9 1.9 2.1 2 0 0 2 2 2 0 Tropomyosin like ADIP PF11559.8 KII64125.1 - 0.041 14.0 7.9 0.11 12.6 0.4 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Mt_ATP-synt_D PF05873.12 KII64125.1 - 0.046 13.6 3.8 1.2 9.0 0.1 2.1 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Laminin_I PF06008.14 KII64125.1 - 0.068 12.9 7.8 0.46 10.1 0.5 2.2 2 0 0 2 2 2 0 Laminin Domain I RapA_C PF12137.8 KII64125.1 - 0.072 12.1 4.3 0.096 11.7 4.3 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Mga PF05043.13 KII64125.1 - 0.072 13.7 0.9 1.2 9.7 0.1 2.2 2 0 0 2 2 2 0 Mga helix-turn-helix domain Jnk-SapK_ap_N PF09744.9 KII64125.1 - 0.087 13.1 11.1 0.12 12.6 0.6 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Seryl_tRNA_N PF02403.22 KII64125.1 - 0.14 12.4 9.7 0.23 11.7 1.9 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Uso1_p115_C PF04871.13 KII64125.1 - 0.17 12.2 11.8 0.3 11.4 11.8 1.4 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region TRAF_BIRC3_bd PF16673.5 KII64125.1 - 0.2 11.4 7.9 1.3 8.8 1.7 2.5 2 1 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain TMPIT PF07851.13 KII64125.1 - 0.21 10.8 10.6 0.28 10.4 1.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein JIP_LZII PF16471.5 KII64125.1 - 0.21 11.8 8.9 2.7 8.2 1.6 2.9 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II T3SSipB PF16535.5 KII64125.1 - 0.22 12.0 6.5 1 9.8 0.4 2.0 1 1 1 2 2 2 0 Type III cell invasion protein SipB Spc7 PF08317.11 KII64125.1 - 0.25 10.2 11.4 0.45 9.4 11.4 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1978 PF09321.10 KII64125.1 - 0.46 9.8 11.3 0.12 11.6 3.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1978) LMBR1 PF04791.16 KII64125.1 - 0.54 9.1 2.8 0.64 8.9 2.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Acyl-CoA_ox_N PF14749.6 KII64125.1 - 0.59 10.7 7.3 0.53 10.8 0.6 2.0 1 1 1 2 2 2 0 Acyl-coenzyme A oxidase N-terminal PspA_IM30 PF04012.12 KII64125.1 - 1.1 8.8 9.7 0.65 9.5 1.9 2.1 2 0 0 2 2 2 0 PspA/IM30 family UPF0242 PF06785.11 KII64125.1 - 1.4 9.0 10.7 2.4 8.2 10.7 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus BRE1 PF08647.11 KII64125.1 - 1.6 8.8 16.3 2 8.6 4.0 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF4140 PF13600.6 KII64125.1 - 1.7 9.2 6.4 5.5 7.5 1.7 2.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) MRPL52 PF18699.1 KII64125.1 - 2.5 8.4 8.4 2.2 8.5 1.2 2.1 2 0 0 2 2 2 0 Mitoribosomal protein mL52 Lectin_N PF03954.14 KII64125.1 - 2.5 7.9 6.0 8.1 6.2 2.0 2.2 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain IZUMO PF15005.6 KII64125.1 - 3.4 8.2 6.5 18 5.9 0.4 2.1 1 1 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Swi5 PF07061.11 KII64125.1 - 10 6.3 11.0 4e+03 -2.0 11.0 3.0 1 1 0 1 1 1 0 Swi5 RT_RNaseH PF17917.1 KII64126.1 - 5.8e-16 58.7 0.0 7.2e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII64126.1 - 9e-10 38.5 0.0 1.3e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase THDPS_M PF14789.6 KII64127.1 - 0.098 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase middle RVT_1 PF00078.27 KII64129.1 - 1.5e-32 112.9 0.0 3.7e-32 111.6 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII64129.1 - 1.4e-31 108.5 0.0 3.9e-31 107.0 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64129.1 - 3e-29 101.4 0.0 6.5e-29 100.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII64129.1 - 1.2e-23 83.5 0.0 3.4e-23 82.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64129.1 - 4.1e-20 71.6 0.3 1e-19 70.4 0.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII64129.1 - 0.00034 20.3 1.5 0.085 12.6 0.0 2.9 2 0 0 2 2 2 1 Integrase core domain RVP PF00077.20 KII64129.1 - 0.0018 18.6 0.0 0.0043 17.3 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease DDE_Tnp_IS240 PF13610.6 KII64129.1 - 0.0046 17.2 0.0 0.018 15.2 0.0 2.0 1 0 0 1 1 1 1 DDE domain Asp_protease PF09668.10 KII64129.1 - 0.028 14.2 0.0 0.064 13.1 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease zf-H2C2 PF09337.10 KII64129.1 - 0.028 14.6 0.0 0.081 13.2 0.0 1.9 1 0 0 1 1 1 0 H2C2 zinc finger zf-CCHC PF00098.23 KII64129.1 - 0.053 13.6 1.5 0.11 12.7 1.5 1.5 1 0 0 1 1 1 0 Zinc knuckle Asp_protease_2 PF13650.6 KII64129.1 - 0.18 12.4 0.0 0.49 11.1 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease GAT PF03127.14 KII64130.1 - 0.0037 17.5 2.2 0.13 12.6 0.1 2.3 2 1 0 2 2 2 1 GAT domain JAKMIP_CC3 PF16034.5 KII64130.1 - 0.0047 16.9 1.7 0.0056 16.6 1.7 1.2 1 0 0 1 1 1 1 JAKMIP CC3 domain APG17 PF04108.12 KII64130.1 - 0.0075 15.4 1.6 0.0095 15.1 1.6 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 TMF_TATA_bd PF12325.8 KII64130.1 - 0.011 15.9 5.9 0.49 10.6 3.1 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 KII64130.1 - 0.013 15.3 4.0 0.052 13.3 0.1 2.4 2 1 0 2 2 2 0 Septum formation initiator Phage_GP20 PF06810.11 KII64130.1 - 0.021 14.6 3.0 0.079 12.8 0.6 2.0 2 0 0 2 2 2 0 Phage minor structural protein GP20 GrpE PF01025.19 KII64130.1 - 0.028 14.1 4.2 0.5 10.0 1.1 2.0 2 0 0 2 2 2 0 GrpE bZIP_1 PF00170.21 KII64130.1 - 0.079 13.1 0.3 0.079 13.1 0.3 2.7 2 1 0 2 2 2 0 bZIP transcription factor KLRAQ PF10205.9 KII64130.1 - 0.11 12.8 4.7 4.6 7.6 0.1 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Prefoldin PF02996.17 KII64130.1 - 0.22 11.4 5.7 0.68 9.8 0.7 2.2 1 1 2 3 3 3 0 Prefoldin subunit LMBR1 PF04791.16 KII64130.1 - 0.39 9.6 1.1 0.44 9.4 1.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein ABC_tran_CTD PF16326.5 KII64130.1 - 0.42 10.9 7.3 3.8 7.8 2.0 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain DDE_3 PF13358.6 KII64131.1 - 2.6e-17 62.9 0.1 3.4e-16 59.3 0.1 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII64131.1 - 0.0015 18.7 0.0 0.0029 17.8 0.0 1.4 1 0 0 1 1 1 1 Transposase ABC_tran_CTD PF16326.5 KII64133.1 - 4e-06 27.0 9.8 0.0036 17.5 1.1 2.4 1 1 1 2 2 2 2 ABC transporter C-terminal domain CENP-F_leu_zip PF10473.9 KII64133.1 - 3.6e-05 23.8 8.7 0.00054 20.0 1.3 2.1 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lebercilin PF15619.6 KII64133.1 - 6.5e-05 22.7 5.8 9.4e-05 22.2 5.8 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DUF1192 PF06698.11 KII64133.1 - 0.00029 20.8 5.9 0.00059 19.8 0.6 2.7 3 0 0 3 3 2 1 Protein of unknown function (DUF1192) HMMR_N PF15905.5 KII64133.1 - 0.00039 20.0 8.6 0.00045 19.8 8.6 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Filament PF00038.21 KII64133.1 - 0.00083 19.0 8.7 0.059 12.9 0.8 2.1 1 1 1 2 2 2 2 Intermediate filament protein Spc7 PF08317.11 KII64133.1 - 0.001 18.0 5.9 0.0014 17.6 5.9 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein KxDL PF10241.9 KII64133.1 - 0.0025 18.1 7.3 0.044 14.1 0.4 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein Med9 PF07544.13 KII64133.1 - 0.0028 17.7 15.1 0.085 13.0 1.3 3.2 1 1 2 3 3 3 1 RNA polymerase II transcription mediator complex subunit 9 GrpE PF01025.19 KII64133.1 - 0.0029 17.3 6.4 0.004 16.8 6.4 1.3 1 0 0 1 1 1 1 GrpE DUF4600 PF15372.6 KII64133.1 - 0.004 17.6 10.0 0.12 12.8 5.1 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4600) Seryl_tRNA_N PF02403.22 KII64133.1 - 0.0044 17.2 9.7 0.39 11.0 5.4 2.4 2 1 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DUF4618 PF15397.6 KII64133.1 - 0.0049 16.3 11.4 0.73 9.2 0.2 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF4618) DUF2682 PF10909.8 KII64133.1 - 0.0057 17.1 0.7 0.0057 17.1 0.7 1.8 2 0 0 2 2 1 1 Protein of unknown function (DUF2682) LXG PF04740.12 KII64133.1 - 0.0066 16.2 9.7 0.24 11.1 4.0 2.2 1 1 1 2 2 2 2 LXG domain of WXG superfamily DUF4988 PF16378.5 KII64133.1 - 0.0068 16.1 4.8 0.0096 15.6 2.7 2.1 1 1 2 3 3 2 1 Domain of unknown function Fez1 PF06818.15 KII64133.1 - 0.0075 16.7 3.1 0.01 16.3 3.1 1.2 1 0 0 1 1 1 1 Fez1 Exonuc_VII_L PF02601.15 KII64133.1 - 0.0088 15.6 2.4 0.01 15.4 2.4 1.0 1 0 0 1 1 1 1 Exonuclease VII, large subunit TMPIT PF07851.13 KII64133.1 - 0.015 14.6 7.0 0.03 13.6 7.0 1.4 1 1 0 1 1 1 0 TMPIT-like protein DivIC PF04977.15 KII64133.1 - 0.015 15.1 15.0 0.25 11.2 1.4 3.2 1 1 2 3 3 3 0 Septum formation initiator DUF2353 PF09789.9 KII64133.1 - 0.016 14.6 8.4 0.15 11.4 8.3 2.0 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) MnmE_helical PF12631.7 KII64133.1 - 0.017 15.3 3.1 0.025 14.8 3.1 1.3 1 0 0 1 1 1 0 MnmE helical domain PKcGMP_CC PF16808.5 KII64133.1 - 0.021 14.6 0.8 0.021 14.6 0.8 2.6 3 0 0 3 3 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF724 PF05266.14 KII64133.1 - 0.023 14.5 7.0 0.73 9.6 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) BST2 PF16716.5 KII64133.1 - 0.027 15.0 13.2 0.3 11.7 0.9 3.0 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 DUF1664 PF07889.12 KII64133.1 - 0.029 14.4 8.6 0.67 10.0 1.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) THOC7 PF05615.13 KII64133.1 - 0.029 14.6 10.9 0.48 10.7 0.8 3.0 2 1 1 3 3 3 0 Tho complex subunit 7 GAS PF13851.6 KII64133.1 - 0.031 13.6 12.3 0.33 10.3 12.0 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4140 PF13600.6 KII64133.1 - 0.036 14.5 5.3 0.53 10.8 0.1 2.8 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) BLOC1_2 PF10046.9 KII64133.1 - 0.039 14.2 10.0 0.18 12.1 1.8 2.7 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ALIX_LYPXL_bnd PF13949.6 KII64133.1 - 0.039 13.2 8.1 0.23 10.7 8.1 1.9 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV Bcr-Abl_Oligo PF09036.10 KII64133.1 - 0.042 13.9 10.0 2.3 8.3 0.6 3.1 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain ADIP PF11559.8 KII64133.1 - 0.044 13.9 9.1 0.34 11.0 3.2 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3450 PF11932.8 KII64133.1 - 0.045 13.0 8.5 0.071 12.4 2.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DASH_Dam1 PF08653.10 KII64133.1 - 0.06 13.2 1.9 13 5.7 0.0 3.3 3 1 0 3 3 3 0 DASH complex subunit Dam1 Prefoldin PF02996.17 KII64133.1 - 0.061 13.2 16.8 2.3 8.2 0.9 3.1 2 1 0 3 3 3 0 Prefoldin subunit DUF4201 PF13870.6 KII64133.1 - 0.063 13.0 13.2 0.83 9.4 6.2 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Peptidase_C65 PF10275.9 KII64133.1 - 0.063 12.7 4.7 0.042 13.3 1.6 1.9 1 1 1 2 2 2 0 Peptidase C65 Otubain DUF16 PF01519.16 KII64133.1 - 0.066 13.7 12.5 2.5 8.6 9.3 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Snapin_Pallidin PF14712.6 KII64133.1 - 0.067 13.6 9.8 0.55 10.7 0.8 2.6 1 1 1 2 2 2 0 Snapin/Pallidin Vps51 PF08700.11 KII64133.1 - 0.07 13.2 8.9 0.48 10.5 0.2 3.1 2 1 1 3 3 3 0 Vps51/Vps67 DHR10 PF18595.1 KII64133.1 - 0.072 13.1 8.7 2.8 8.0 0.3 2.7 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain Terpene_synth_C PF03936.16 KII64133.1 - 0.074 12.4 2.2 0.12 11.7 2.2 1.5 1 1 0 1 1 1 0 Terpene synthase family, metal binding domain DUF2203 PF09969.9 KII64133.1 - 0.078 13.7 5.7 0.25 12.1 0.8 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Mod_r PF07200.13 KII64133.1 - 0.079 13.1 8.3 0.58 10.3 7.1 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Baculo_PEP_C PF04513.12 KII64133.1 - 0.082 13.0 4.2 0.55 10.3 0.7 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Csm1_N PF18504.1 KII64133.1 - 0.085 13.2 8.4 5.7 7.4 0.1 3.1 3 0 0 3 3 3 0 Csm1 N-terminal domain K-box PF01486.17 KII64133.1 - 0.097 12.9 8.5 0.4 10.9 2.8 2.7 2 1 0 2 2 2 0 K-box region DUF4164 PF13747.6 KII64133.1 - 0.099 12.9 3.8 0.54 10.6 0.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) TPR_MLP1_2 PF07926.12 KII64133.1 - 0.1 12.7 10.1 4.3 7.4 9.5 2.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Laminin_II PF06009.12 KII64133.1 - 0.11 12.5 7.7 7.9 6.5 7.5 2.3 1 1 0 1 1 1 0 Laminin Domain II APG6_N PF17675.1 KII64133.1 - 0.12 12.9 12.4 3.7 8.1 3.2 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region TcdB_N PF12918.7 KII64133.1 - 0.12 12.6 1.0 0.12 12.6 1.0 3.0 3 0 0 3 3 3 0 TcdB toxin N-terminal helical domain CEP209_CC5 PF16574.5 KII64133.1 - 0.16 12.1 8.0 0.21 11.8 2.0 2.3 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 DUF3740 PF12548.8 KII64133.1 - 0.17 12.3 11.1 3.7 8.0 0.5 3.3 3 0 0 3 3 3 0 Sulfatase protein CdvA PF18822.1 KII64133.1 - 0.17 11.7 14.7 0.062 13.1 5.9 2.2 1 1 1 2 2 2 0 CdvA-like coiled-coil domain DMPK_coil PF08826.10 KII64133.1 - 0.17 12.0 10.4 2.7 8.2 0.5 3.1 3 0 0 3 3 3 0 DMPK coiled coil domain like Wtap PF17098.5 KII64133.1 - 0.17 11.8 6.5 3.8 7.4 6.5 2.1 1 1 0 1 1 1 0 WTAP/Mum2p family HIP1_clath_bdg PF16515.5 KII64133.1 - 0.19 12.4 6.8 1.1 9.9 2.0 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Snf7 PF03357.21 KII64133.1 - 0.19 11.3 14.5 0.41 10.2 0.4 2.4 2 1 0 2 2 2 0 Snf7 FapA PF03961.13 KII64133.1 - 0.21 10.1 15.2 0.25 9.9 7.4 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4795 PF16043.5 KII64133.1 - 0.23 11.0 9.6 2.3 7.8 9.6 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) HR1 PF02185.16 KII64133.1 - 0.23 11.6 8.9 2.2 8.5 0.6 2.8 3 0 0 3 3 3 0 Hr1 repeat STAT_alpha PF01017.20 KII64133.1 - 0.23 11.3 8.7 7.4 6.4 8.7 2.3 1 1 0 1 1 1 0 STAT protein, all-alpha domain ATG16 PF08614.11 KII64133.1 - 0.24 11.6 5.6 1.5 9.0 0.3 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Prefoldin_2 PF01920.20 KII64133.1 - 0.24 11.4 18.6 1.2 9.1 1.6 3.1 2 1 1 3 3 3 0 Prefoldin subunit FlxA PF14282.6 KII64133.1 - 0.27 11.2 13.9 0.053 13.5 5.1 2.6 2 1 0 2 2 2 0 FlxA-like protein FliJ PF02050.16 KII64133.1 - 0.27 11.5 8.1 0.34 11.1 2.4 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein PRKG1_interact PF15898.5 KII64133.1 - 0.27 12.1 11.7 5.8 7.9 1.6 3.0 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Tropomyosin PF00261.20 KII64133.1 - 0.28 10.5 10.8 2.7 7.3 0.5 2.2 1 1 0 2 2 2 0 Tropomyosin DUF948 PF06103.11 KII64133.1 - 0.29 11.4 3.6 17 5.8 0.1 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) FAP206 PF12018.8 KII64133.1 - 0.29 10.6 5.8 1 8.8 6.0 1.6 1 1 1 2 2 2 0 Domain of unknown function TMF_TATA_bd PF12325.8 KII64133.1 - 0.32 11.2 8.5 2.2 8.5 3.7 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding FAM76 PF16046.5 KII64133.1 - 0.33 10.2 9.0 0.53 9.6 9.0 1.4 1 1 0 1 1 1 0 FAM76 protein Laminin_I PF06008.14 KII64133.1 - 0.34 10.6 8.2 1 9.0 8.2 1.7 1 1 0 1 1 1 0 Laminin Domain I CREPT PF16566.5 KII64133.1 - 0.37 10.9 8.1 4.5 7.4 8.1 2.0 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour FlaC_arch PF05377.11 KII64133.1 - 0.4 11.1 17.2 2.7 8.5 1.9 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TSC22 PF01166.18 KII64133.1 - 0.43 10.9 9.4 3 8.2 0.7 3.0 3 1 0 3 3 2 0 TSC-22/dip/bun family XkdW PF09636.10 KII64133.1 - 0.44 10.6 9.7 1.1 9.3 1.0 2.9 2 1 1 3 3 3 0 XkdW protein SOGA PF11365.8 KII64133.1 - 0.45 11.7 11.6 3.5 8.8 4.6 3.1 2 1 0 2 2 2 0 Protein SOGA BRCC36_C PF18110.1 KII64133.1 - 0.5 10.6 0.1 0.5 10.6 0.1 2.4 2 1 0 2 2 2 0 BRCC36 C-terminal helical domain Fib_alpha PF08702.10 KII64133.1 - 0.51 10.5 11.9 6.6 6.9 11.9 2.2 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF2115 PF09888.9 KII64133.1 - 0.53 10.8 6.9 4.3 7.8 6.6 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) LPP PF04728.13 KII64133.1 - 0.59 10.6 3.9 13 6.2 0.1 3.1 2 1 1 3 3 3 0 Lipoprotein leucine-zipper GreA_GreB_N PF03449.15 KII64133.1 - 0.6 10.3 7.6 3.9 7.7 0.1 3.4 3 0 0 3 3 3 0 Transcription elongation factor, N-terminal bZIP_1 PF00170.21 KII64133.1 - 0.63 10.2 13.5 1.8 8.7 0.5 3.4 3 1 0 3 3 3 0 bZIP transcription factor YabA PF06156.13 KII64133.1 - 0.74 10.5 10.4 7.9 7.2 0.7 2.7 1 1 1 2 2 2 0 Initiation control protein YabA DUF4094 PF13334.6 KII64133.1 - 0.81 10.1 6.5 1.9 9.0 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) DUF4200 PF13863.6 KII64133.1 - 0.96 9.9 19.1 3.6 8.0 1.4 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) SlyX PF04102.12 KII64133.1 - 1 10.0 8.6 1.1 9.9 3.6 2.6 2 1 0 2 2 2 0 SlyX Uso1_p115_C PF04871.13 KII64133.1 - 1.1 9.6 9.2 7.4 7.0 8.7 2.1 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spore_III_AB PF09548.10 KII64133.1 - 1.2 9.2 7.3 4.9 7.2 7.4 1.7 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF2205 PF10224.9 KII64133.1 - 1.3 9.1 7.6 2.6 8.1 3.5 2.6 2 1 0 2 2 2 0 Short coiled-coil protein CCDC-167 PF15188.6 KII64133.1 - 1.4 9.3 12.5 1.5 9.2 5.4 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 XhlA PF10779.9 KII64133.1 - 1.5 9.1 13.4 1.2 9.3 0.4 3.4 3 0 0 3 3 3 0 Haemolysin XhlA AAA_lid_9 PF17871.1 KII64133.1 - 1.6 8.7 11.4 0.57 10.1 0.6 2.8 1 1 1 3 3 3 0 AAA lid domain Sec2p PF06428.11 KII64133.1 - 1.6 8.7 10.0 2 8.4 0.9 2.8 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p betaPIX_CC PF16523.5 KII64133.1 - 1.7 8.5 10.0 0.49 10.3 1.5 2.8 2 1 0 2 2 2 0 betaPIX coiled coil EMP24_GP25L PF01105.24 KII64133.1 - 1.7 8.5 8.9 0.98 9.3 0.6 2.4 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD ISG65-75 PF11727.8 KII64133.1 - 1.8 7.7 5.2 8 5.6 5.2 1.8 1 1 0 1 1 1 0 Invariant surface glycoprotein DUF1640 PF07798.11 KII64133.1 - 2 8.5 10.8 0.94 9.5 3.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) TMF_DNA_bd PF12329.8 KII64133.1 - 2.4 8.2 18.9 0.71 9.9 0.7 3.0 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding LMBR1 PF04791.16 KII64133.1 - 2.5 6.9 4.9 2.7 6.8 4.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Rx_N PF18052.1 KII64133.1 - 2.7 8.3 7.2 22 5.4 1.7 3.0 2 1 0 2 2 2 0 Rx N-terminal domain Rotamase PF00639.21 KII64133.1 - 2.8 9.0 6.1 7.1 7.7 0.6 2.7 2 1 1 3 3 2 0 PPIC-type PPIASE domain DUF5082 PF16888.5 KII64133.1 - 2.8 8.2 18.9 3.1 8.1 2.3 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) Spc24 PF08286.11 KII64133.1 - 2.8 8.2 11.6 4.6 7.5 3.1 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Swi5 PF07061.11 KII64133.1 - 2.9 8.0 11.8 9.8e+02 -0.1 11.7 2.9 1 1 0 1 1 1 0 Swi5 Noelin-1 PF12308.8 KII64133.1 - 3.4 7.7 5.6 3.1 7.8 0.6 2.2 1 1 1 2 2 2 0 Neurogenesis glycoprotein TLE_N PF03920.15 KII64133.1 - 3.4 7.7 9.6 7.4 6.7 0.3 3.0 2 1 1 3 3 3 0 Groucho/TLE N-terminal Q-rich domain Val_tRNA-synt_C PF10458.9 KII64133.1 - 3.5 8.0 10.9 19 5.6 0.0 3.1 3 0 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm DUF5320 PF17253.2 KII64133.1 - 3.8 8.6 7.7 8.5 7.5 0.1 3.1 3 1 0 3 3 3 0 Family of unknown function (DUF5320) ACCA PF03255.14 KII64133.1 - 4.2 7.3 9.8 1.2 9.1 1.7 2.3 1 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ECM11 PF15463.6 KII64133.1 - 4.6 7.8 8.4 7.5 7.1 1.4 2.6 1 1 2 3 3 2 0 Extracellular mutant protein 11 Paralemmin PF03285.15 KII64133.1 - 5.4 6.5 9.0 16 4.9 9.0 1.8 1 1 0 1 1 1 0 Paralemmin DUF5595 PF18077.1 KII64133.1 - 5.5 7.2 10.0 1.5 9.0 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) bZIP_2 PF07716.15 KII64133.1 - 8 6.6 16.5 0.68 10.1 2.3 3.0 2 1 1 3 3 3 0 Basic region leucine zipper DUF2802 PF10975.8 KII64133.1 - 8.4 6.6 7.1 4.4e+02 1.1 7.1 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2802) BRI3BP PF14965.6 KII64133.1 - 8.6 5.8 5.2 1.7 8.2 0.2 2.1 3 0 0 3 3 2 0 Negative regulator of p53/TP53 YbjN PF10722.9 KII64136.1 - 0.057 13.5 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Putative bacterial sensory transduction regulator ArsC PF03960.15 KII64137.1 - 2.8e-19 68.9 0.0 4.2e-19 68.3 0.0 1.3 1 1 0 1 1 1 1 ArsC family PGM_PMM_IV PF00408.20 KII64137.1 - 0.11 12.6 0.4 0.97 9.7 0.0 2.4 2 1 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain CotJB PF12652.7 KII64137.1 - 0.2 11.9 0.0 0.33 11.2 0.0 1.3 1 0 0 1 1 1 0 CotJB protein ArsB PF02040.15 KII64138.1 - 2.8e-86 290.5 11.0 3.1e-86 290.3 11.0 1.0 1 0 0 1 1 1 1 Arsenical pump membrane protein CitMHS PF03600.16 KII64138.1 - 7.9e-09 35.1 13.5 7.9e-09 35.1 13.5 2.1 1 1 1 2 2 2 1 Citrate transporter CagE_TrbE_VirB PF03135.14 KII64138.1 - 0.11 12.5 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system FMN_red PF03358.15 KII64140.1 - 8.6e-28 97.0 0.0 1.2e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 KII64140.1 - 0.0002 21.1 0.0 0.00032 20.5 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin-like fold LptF_LptG PF03739.14 KII64142.1 - 0.035 13.0 0.5 0.035 13.0 0.5 1.6 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG PilI PF10623.9 KII64142.1 - 0.52 10.5 2.0 8.8 6.6 0.3 2.5 2 0 0 2 2 2 0 Plasmid conjugative transfer protein PilI DUF4835 PF16119.5 KII64142.1 - 0.75 8.8 11.2 0.58 9.2 8.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4835) zf-H2C2_5 PF13909.6 KII64143.1 - 5.8e-05 22.8 0.0 5.8e-05 22.8 0.0 3.1 4 0 0 4 4 4 1 C2H2-type zinc-finger domain OrsD PF12013.8 KII64143.1 - 7.7e-05 23.1 5.9 0.029 14.8 0.7 2.8 2 1 0 2 2 2 2 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_4 PF13894.6 KII64143.1 - 0.00024 21.7 14.4 0.11 13.4 0.3 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KII64143.1 - 0.0026 18.1 0.1 0.0026 18.1 0.1 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 KII64143.1 - 0.0035 17.7 14.3 0.13 12.7 0.3 3.8 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 KII64143.1 - 0.0087 16.3 0.1 0.0087 16.3 0.1 2.7 3 1 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 KII64143.1 - 0.16 11.7 7.1 5.8 6.6 3.9 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-TRAF PF02176.18 KII64143.1 - 0.23 12.2 14.8 0.083 13.6 4.3 3.2 2 1 1 3 3 3 0 TRAF-type zinc finger zf-H2C2_2 PF13465.6 KII64144.1 - 0.032 14.7 0.2 0.032 14.7 0.2 2.6 3 0 0 3 3 3 0 Zinc-finger double domain Serpin PF00079.20 KII64148.1 - 1.1e-53 182.9 3.4 1.2e-53 182.7 3.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Insulin_TMD PF17870.1 KII64149.1 - 0.088 12.9 2.3 0.2 11.8 2.3 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Serpin PF00079.20 KII64150.1 - 5.2e-21 75.4 0.2 6e-21 75.2 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Anophelin PF10731.9 KII64153.1 - 0.033 14.1 0.4 0.033 14.1 0.4 1.6 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito TFIID-31kDa PF02291.15 KII64161.1 - 9.1e-15 54.8 0.0 1.2e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF935 PF06074.12 KII64163.1 - 0.2 10.3 0.0 0.25 10.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF935) DDE_Tnp_IS1595 PF12762.7 KII64164.1 - 0.011 15.7 0.1 0.012 15.6 0.1 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain Ribosomal_S6e PF01092.19 KII64165.1 - 8.2e-15 54.9 0.0 1.2e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6e DUF4577 PF15145.6 KII64167.1 - 0.0098 15.9 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) SNAP PF14938.6 KII64168.1 - 0.00017 21.2 0.1 0.0002 20.9 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR PF01535.20 KII64168.1 - 0.046 14.0 0.3 0.57 10.5 0.0 2.6 3 0 0 3 3 3 0 PPR repeat TPR_11 PF13414.6 KII64168.1 - 0.16 11.6 0.7 0.74 9.5 0.0 2.4 3 0 0 3 3 3 0 TPR repeat TPR_8 PF13181.6 KII64168.1 - 0.34 11.2 2.2 19 5.8 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Eaf7 PF07904.13 KII64170.1 - 0.0043 17.4 11.1 0.79 10.1 1.0 3.5 1 1 2 3 3 3 3 Chromatin modification-related protein EAF7 FGase PF05013.12 KII64170.1 - 0.32 11.2 1.3 25 5.0 0.1 3.2 2 1 1 3 3 3 0 N-formylglutamate amidohydrolase PH PF00169.29 KII64172.1 - 1.2e-05 25.8 2.0 2.8e-05 24.6 0.3 2.2 2 0 0 2 2 2 1 PH domain PH_4 PF15404.6 KII64172.1 - 0.0028 17.5 3.2 0.014 15.2 0.3 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 KII64172.1 - 0.26 11.7 2.1 0.87 10.0 0.2 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain DHR-2 PF06920.13 KII64173.1 - 3.4e-53 181.1 5.9 1.8e-52 178.7 5.9 1.8 1 1 0 1 1 1 1 Dock homology region 2 UCR_14kD PF02271.16 KII64178.1 - 1.6e-09 37.7 0.0 1.8e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit CARDB PF07705.11 KII64179.1 - 0.068 13.4 0.0 0.17 12.1 0.0 1.7 1 1 1 2 2 2 0 CARDB ArsA_ATPase PF02374.15 KII64179.1 - 0.1 11.7 0.3 0.13 11.4 0.3 1.1 1 0 0 1 1 1 0 Anion-transporting ATPase COMPASS-Shg1 PF05205.12 KII64180.1 - 0.031 15.0 0.7 0.054 14.2 0.2 1.6 2 0 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 rve PF00665.26 KII64181.1 - 5.6e-21 74.9 0.0 1.1e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64181.1 - 3.9e-13 49.3 0.2 9.3e-13 48.1 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII64181.1 - 4.2e-05 23.2 0.3 0.0006 19.5 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII64181.1 - 0.066 13.4 0.2 0.14 12.4 0.2 1.6 1 0 0 1 1 1 0 H2C2 zinc finger rve PF00665.26 KII64182.1 - 8e-25 87.4 0.0 1.5e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII64182.1 - 0.0017 18.6 0.4 0.0078 16.4 0.0 2.0 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.6 KII64182.1 - 0.0043 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64182.1 - 0.044 13.9 3.5 0.051 13.7 0.8 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain MLVIN_C PF18697.1 KII64182.1 - 0.048 13.8 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Mago-bind PF09282.10 KII64183.1 - 4.8e-11 42.3 0.9 9.4e-11 41.4 0.9 1.5 1 0 0 1 1 1 1 Mago binding TFIIA PF03153.13 KII64183.1 - 5.1 7.0 28.4 5.9 6.8 28.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Integrin_beta PF00362.18 KII64185.1 - 0.19 11.3 0.0 0.2 11.3 0.0 1.3 1 1 0 1 1 1 0 Integrin beta chain VWA domain EGF_2 PF07974.13 KII64186.1 - 0.0042 17.4 11.3 0.0042 17.4 11.3 2.9 2 1 1 3 3 3 1 EGF-like domain I-EGF_1 PF18372.1 KII64186.1 - 0.011 15.8 13.1 0.011 15.8 13.1 3.4 3 1 0 3 3 3 0 Integrin beta epidermal growth factor like domain 1 Integrin_beta PF00362.18 KII64188.1 - 1.3e-18 67.5 0.1 2.9e-18 66.4 0.1 1.5 1 0 0 1 1 1 1 Integrin beta chain VWA domain EGF_2 PF07974.13 KII64188.1 - 9.6e-07 29.1 60.6 0.00024 21.4 16.8 4.2 4 0 0 4 4 4 2 EGF-like domain GPDPase_memb PF10110.9 KII64188.1 - 1.5 7.5 8.9 7.8 5.2 0.4 3.1 3 0 0 3 3 3 0 Membrane domain of glycerophosphoryl diester phosphodiesterase Fe-S_assembly PF04384.13 KII64191.1 - 0.11 13.1 0.2 10 6.8 0.0 2.9 1 1 2 3 3 3 0 Iron-sulphur cluster assembly DUF3135 PF11333.8 KII64191.1 - 0.17 12.1 0.5 1.1 9.5 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3135) RAM PF15320.6 KII64191.1 - 0.41 11.3 4.4 1.7 9.3 0.4 2.4 1 1 2 3 3 3 0 mRNA cap methylation, RNMT-activating mini protein Sortilin_C PF15901.5 KII64192.1 - 1.3e-12 48.4 1.4 1.6e-12 48.1 1.4 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal rve PF00665.26 KII64193.1 - 1.1e-22 80.4 0.0 2.8e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64193.1 - 9.2e-13 48.1 0.8 2.1e-12 47.0 0.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII64193.1 - 0.012 15.3 1.6 0.013 15.2 0.0 2.0 2 0 0 2 2 2 0 Integrase core domain Sortilin-Vps10 PF15902.5 KII64194.1 - 1.8e-11 43.5 0.2 3.3e-11 42.7 0.2 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII64194.1 - 9.2e-06 24.9 2.0 0.11 12.6 0.3 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat Complex1_51K PF01512.17 KII64197.1 - 0.091 12.6 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit Pkinase PF00069.25 KII64201.1 - 2.7e-20 72.8 0.2 3.3e-20 72.6 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII64201.1 - 1.2e-15 57.5 0.1 4.6e-15 55.6 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KII64201.1 - 0.087 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DDE_1 PF03184.19 KII64202.1 - 1.2e-13 51.1 1.2 1.6e-13 50.6 0.0 1.8 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII64202.1 - 0.0013 18.7 1.0 0.0022 18.0 1.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF4368 PF14287.6 KII64205.1 - 0.027 14.8 0.2 0.57 10.5 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4368) SNAP PF14938.6 KII64207.1 - 2.9e-08 33.5 0.0 4.4e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SNAP PF14938.6 KII64208.1 - 0.013 15.0 0.6 0.021 14.3 0.1 1.6 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP DehI PF10778.9 KII64208.1 - 0.086 13.0 0.2 0.19 11.9 0.1 1.7 2 0 0 2 2 2 0 Halocarboxylic acid dehydrogenase DehI COPI_C PF06957.11 KII64214.1 - 0.093 11.5 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus DUF3310 PF11753.8 KII64215.1 - 0.086 13.1 0.2 1.2 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknwon function (DUF3310) MMS19_N PF14500.6 KII64215.1 - 0.091 12.3 0.0 0.095 12.3 0.0 1.2 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF4448 PF14610.6 KII64217.1 - 0.094 12.5 0.1 0.21 11.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) G-patch PF01585.23 KII64219.1 - 1.1e-08 34.8 0.5 3e-08 33.4 0.2 1.9 3 0 0 3 3 3 1 G-patch domain G-patch_2 PF12656.7 KII64219.1 - 0.0078 16.3 0.4 0.017 15.2 0.1 1.7 1 1 1 2 2 2 1 G-patch domain DnaJ PF00226.31 KII64221.1 - 1.8e-07 31.2 0.0 4.2e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DDE_3 PF13358.6 KII64222.1 - 3.8e-05 23.5 0.0 4.3e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease GYF_2 PF14237.6 KII64223.1 - 2.8e-17 62.2 0.6 5.8e-17 61.2 0.6 1.5 1 0 0 1 1 1 1 GYF domain 2 SUD-M PF11633.8 KII64223.1 - 0.084 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Single-stranded poly(A) binding domain FHA PF00498.26 KII64225.1 - 1.2e-10 41.6 0.0 2.4e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KII64225.1 - 0.061 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain dsrm PF00035.26 KII64225.1 - 0.077 13.7 0.0 0.27 12.0 0.0 1.9 1 0 0 1 1 1 0 Double-stranded RNA binding motif CREPT PF16566.5 KII64225.1 - 0.28 11.3 7.8 0.29 11.3 2.0 2.3 1 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Staygreen PF12638.7 KII64226.1 - 0.065 13.0 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Staygreen protein NifU_N PF01592.16 KII64230.1 - 8.8e-54 181.1 0.3 1.2e-53 180.7 0.3 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain Tho2 PF11262.8 KII64231.1 - 0.039 13.2 0.6 0.088 12.0 0.6 1.7 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 RVT_1 PF00078.27 KII64232.1 - 0.0003 20.4 0.1 0.12 11.9 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.22 KII64233.1 - 1.2e-06 28.2 0.0 1.7e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDE_3 PF13358.6 KII64235.1 - 8.1e-17 61.3 0.0 1.6e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII64235.1 - 2.9e-07 30.0 0.0 4.5e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII64235.1 - 0.00089 19.5 0.1 0.0014 18.8 0.1 1.4 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 KII64235.1 - 0.018 15.7 0.0 0.035 14.7 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Nuc_rec_co-act PF08815.10 KII64235.1 - 0.023 14.5 0.2 0.097 12.5 0.0 1.8 2 0 0 2 2 2 0 Nuclear receptor coactivator HTH_Tnp_1_2 PF13022.6 KII64235.1 - 0.026 14.7 0.1 0.041 14.0 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase B5 PF03484.15 KII64235.1 - 0.13 12.6 0.0 0.18 12.1 0.0 1.5 1 1 0 1 1 1 0 tRNA synthetase B5 domain Peptidase_M15_2 PF05951.13 KII64236.1 - 0.068 12.8 0.1 0.74 9.5 0.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) Voltage_CLC PF00654.20 KII64237.1 - 7.3e-65 219.5 14.5 7.3e-65 219.5 14.5 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KII64237.1 - 5.5e-06 26.7 0.0 0.00041 20.7 0.0 2.9 2 0 0 2 2 2 1 CBS domain TFIIE_beta PF02186.15 KII64238.1 - 4.4e-09 36.5 0.1 1.4e-08 34.9 0.0 1.9 2 0 0 2 2 2 1 TFIIE beta subunit core domain PEMT PF04191.13 KII64239.1 - 2.2 8.7 5.3 23 5.4 1.4 2.2 2 0 0 2 2 2 0 Phospholipid methyltransferase DDE_3 PF13358.6 KII64240.1 - 3e-16 59.5 0.0 1.9e-14 53.6 0.0 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII64240.1 - 6e-06 25.8 0.0 1.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix Myosin_head PF00063.21 KII64241.1 - 7.3e-132 440.9 0.3 8.2e-132 440.7 0.3 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 KII64241.1 - 0.0057 17.1 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KII64241.1 - 0.006 16.9 0.0 0.015 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KII64241.1 - 0.01 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_10 PF12846.7 KII64241.1 - 0.021 13.8 0.0 0.036 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain DUF2075 PF09848.9 KII64241.1 - 0.052 12.8 0.0 0.085 12.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 KII64241.1 - 0.12 12.8 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.26 KII64241.1 - 0.13 11.9 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.20 KII64241.1 - 0.13 11.3 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Myosin_head PF00063.21 KII64242.1 - 7.2e-66 222.8 0.0 1.1e-65 222.2 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KII64242.1 - 3.7e-27 95.2 3.1 3.7e-27 95.2 3.1 1.8 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 KII64242.1 - 7.8e-17 60.6 0.1 1.8e-16 59.5 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KII64242.1 - 8.3e-15 54.2 0.0 2.2e-14 52.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 KII64242.1 - 4.1e-14 52.2 0.0 9e-14 51.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Pinin_SDK_memA PF04696.13 KII64243.1 - 9.6e-21 74.2 13.6 9.6e-21 74.2 13.6 1.8 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region DUF1682 PF07946.14 KII64243.1 - 0.012 14.8 6.5 0.017 14.3 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF5392 PF17370.2 KII64243.1 - 0.83 9.7 6.1 1.3 9.1 2.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5392) DUF2856 PF11043.8 KII64243.1 - 1.4 9.1 4.5 1.3 9.2 2.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2856) IL32 PF15225.6 KII64243.1 - 2.1 8.7 4.6 4 7.9 0.0 2.5 2 0 0 2 2 2 0 Interleukin 32 Oxysterol_BP PF01237.18 KII64246.1 - 2.9e-116 388.4 0.1 4e-116 387.9 0.1 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 KII64246.1 - 1.8e-08 34.8 0.1 4.6e-08 33.5 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KII64246.1 - 0.00031 21.0 0.4 0.00073 19.8 0.4 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KII64246.1 - 0.066 13.6 4.6 0.41 11.1 4.6 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain Methyltransf_12 PF08242.12 KII64248.1 - 9.2e-10 39.2 0.0 1.8e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KII64248.1 - 3.3e-06 27.7 0.0 5.1e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII64248.1 - 6e-05 22.9 0.0 7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KII64248.1 - 0.00011 21.7 0.0 0.00018 21.0 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.12 KII64248.1 - 0.0015 19.1 0.0 0.0026 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KII64248.1 - 0.0018 17.8 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain GCR1_C PF12550.8 KII64248.1 - 0.05 13.9 0.7 0.095 13.0 0.7 1.4 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes DDE_3 PF13358.6 KII64249.1 - 1.2e-24 86.7 0.0 1.7e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII64249.1 - 0.039 13.6 0.0 0.25 11.0 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix HAP2-GCS1 PF10699.9 KII64250.1 - 4.2e-14 52.2 0.0 1e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 Male gamete fusion factor Annexin PF00191.20 KII64251.1 - 8.1e-22 77.1 1.0 7.8e-19 67.5 0.1 2.7 3 0 0 3 3 3 2 Annexin Tubulin PF00091.25 KII64252.1 - 1.9e-67 227.3 0.0 3.3e-67 226.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KII64252.1 - 9.8e-38 129.2 0.1 1.5e-37 128.5 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KII64252.1 - 6.9e-06 26.4 0.0 1.6e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 KII64252.1 - 0.025 13.8 0.0 0.052 12.7 0.0 1.6 2 0 0 2 2 2 0 Tubulin like DDE_Tnp_IS1595 PF12762.7 KII64253.1 - 3.1e-09 37.0 0.0 7.1e-09 35.8 0.0 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain Dak2 PF02734.17 KII64253.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 DAK2 domain DDE_Tnp_IS1595 PF12762.7 KII64254.1 - 6.8e-15 55.4 0.0 7.3e-15 55.3 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain CSD PF00313.22 KII64255.1 - 0.16 11.9 0.9 0.46 10.4 0.2 2.0 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain G-alpha PF00503.20 KII64258.1 - 4.4e-81 272.8 5.8 5.8e-81 272.4 5.8 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KII64258.1 - 2.9e-09 36.6 0.0 6.1e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family tRNA_synthFbeta PF17759.1 KII64259.1 - 8.2e-33 113.7 0.0 9.1e-33 113.5 0.0 1.0 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2d PF01409.20 KII64259.1 - 0.023 14.2 0.0 0.029 13.8 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) B3_4 PF03483.17 KII64260.1 - 3.1e-12 46.5 0.0 5.2e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain Proteasome PF00227.26 KII64260.1 - 4.4e-08 32.9 0.0 0.0016 17.9 0.0 2.4 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 KII64260.1 - 5.3e-05 22.8 0.2 0.00012 21.7 0.2 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Brix PF04427.18 KII64261.1 - 9.1e-26 91.2 0.0 1.3e-25 90.6 0.0 1.2 1 0 0 1 1 1 1 Brix domain NDUFA12 PF05071.16 KII64262.1 - 1.6e-23 83.3 0.0 2e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 RVP_2 PF08284.11 KII64263.1 - 0.0059 16.4 0.2 0.047 13.4 0.2 2.1 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII64263.1 - 0.062 14.0 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Fringe PF02434.16 KII64265.1 - 2.5e-08 33.7 0.5 4.4e-08 32.9 0.2 1.5 2 0 0 2 2 2 1 Fringe-like Galactosyl_T PF01762.21 KII64265.1 - 2.1e-06 27.7 0.2 4.1e-06 26.8 0.2 1.4 1 0 0 1 1 1 1 Galactosyltransferase Ribosomal_S24e PF01282.19 KII64266.1 - 7.5e-28 96.3 0.1 7.5e-28 96.3 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein S24e ELO PF01151.18 KII64267.1 - 9.2e-11 41.7 3.1 5.6e-10 39.2 3.1 1.9 1 1 0 1 1 1 1 GNS1/SUR4 family DDE_3 PF13358.6 KII64270.1 - 1.8e-06 27.8 0.0 2.9e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII64270.1 - 5.6e-06 26.0 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.18 KII64270.1 - 0.0012 18.7 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain CENP-B_N PF04218.13 KII64270.1 - 0.0036 16.9 0.0 0.0077 15.8 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.6 KII64270.1 - 0.0053 16.3 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.16 KII64270.1 - 0.0088 15.5 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 MarR_2 PF12802.7 KII64270.1 - 0.011 15.6 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.6 KII64270.1 - 0.012 15.7 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.6 KII64270.1 - 0.013 15.5 0.0 0.035 14.1 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix Sigma70_r4_2 PF08281.12 KII64270.1 - 0.026 14.2 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 TrmB PF01978.19 KII64270.1 - 0.033 14.1 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB CRIC_ras_sig PF10534.9 KII64270.1 - 0.042 14.0 0.1 0.11 12.6 0.0 1.7 2 1 0 2 2 2 0 Connector enhancer of kinase suppressor of ras Phage_CI_repr PF07022.13 KII64270.1 - 0.053 13.6 0.0 0.088 12.9 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain Fe_dep_repress PF01325.19 KII64270.1 - 0.06 13.5 0.0 0.099 12.9 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain LMWPc PF01451.21 KII64270.1 - 0.069 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Low molecular weight phosphotyrosine protein phosphatase HTH_38 PF13936.6 KII64270.1 - 0.099 12.4 0.0 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain ATP-grasp_2 PF08442.10 KII64271.1 - 3.5e-67 225.9 0.0 5.2e-67 225.3 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 KII64271.1 - 1.7e-15 57.2 0.1 2.7e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 KII64271.1 - 9.9e-08 31.7 0.0 1.7e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 KII64271.1 - 0.013 15.2 0.1 0.034 13.9 0.0 1.8 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain gag-asp_proteas PF13975.6 KII64273.1 - 8.2e-08 32.7 0.0 1.9e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.17 KII64273.1 - 0.00013 22.2 0.1 0.00035 20.8 0.1 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein Asp_protease_2 PF13650.6 KII64273.1 - 0.00015 22.3 0.0 0.00034 21.2 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII64273.1 - 0.00027 21.2 0.2 0.0031 17.8 0.1 2.6 2 1 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.23 KII64273.1 - 0.00082 19.3 1.1 0.0014 18.6 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle Asp_protease PF09668.10 KII64273.1 - 0.00093 19.0 0.2 0.0022 17.8 0.2 1.6 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2E PF12382.8 KII64273.1 - 0.0021 18.1 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon peptidase zf-CCHC_5 PF14787.6 KII64273.1 - 0.015 15.0 1.4 0.025 14.3 1.4 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RVP_2 PF08284.11 KII64273.1 - 0.091 12.5 0.3 0.25 11.1 0.3 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease Arc_C PF18162.1 KII64273.1 - 0.11 12.4 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 Arc C-lobe zf-CCHC_2 PF13696.6 KII64273.1 - 0.2 11.5 1.5 0.45 10.4 1.5 1.6 1 0 0 1 1 1 0 Zinc knuckle SlyX PF04102.12 KII64273.1 - 0.25 12.0 0.3 0.25 12.0 0.3 2.3 2 0 0 2 2 2 0 SlyX Nore1-SARAH PF16517.5 KII64274.1 - 0.98 9.4 4.5 2 8.4 2.5 2.3 1 1 1 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Laminin_G_2 PF02210.24 KII64276.1 - 2.1e-40 138.2 0.3 2.9e-11 44.1 0.0 4.5 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.23 KII64276.1 - 2.7e-25 89.1 0.1 3.7e-09 36.9 0.0 5.3 4 1 0 4 4 4 4 Laminin G domain EGF PF00008.27 KII64276.1 - 1.6e-05 25.0 5.1 1.6e-05 25.0 5.1 3.3 3 0 0 3 3 3 2 EGF-like domain Polysacc_lyase PF14099.6 KII64276.1 - 0.005 16.7 0.0 4.3 7.1 0.0 3.4 3 0 0 3 3 3 2 Polysaccharide lyase Thioredoxin PF00085.20 KII64279.1 - 6.2e-15 55.0 0.0 9.5e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KII64279.1 - 0.00012 21.6 0.2 0.00017 21.0 0.2 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KII64279.1 - 0.012 16.0 0.1 0.071 13.6 0.0 2.2 2 1 0 2 2 2 0 Thioredoxin-like domain Stevor PF17410.2 KII64279.1 - 0.15 11.5 1.1 0.22 11.0 1.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Serpin PF00079.20 KII64280.1 - 2.1e-51 175.4 1.4 2.3e-51 175.2 1.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Peptidase_C34 PF05413.11 KII64281.1 - 0.11 12.8 0.9 0.15 12.4 0.2 1.6 2 0 0 2 2 2 0 Putative closterovirus papain-like endopeptidase Thg1 PF04446.12 KII64283.1 - 0.054 13.5 0.2 0.11 12.5 0.2 1.7 1 1 0 1 1 1 0 tRNAHis guanylyltransferase Nudix_N_2 PF14803.6 KII64284.1 - 0.036 14.0 0.8 0.066 13.2 0.8 1.4 1 0 0 1 1 1 0 Nudix N-terminal DZR PF12773.7 KII64284.1 - 0.049 13.7 0.3 0.082 12.9 0.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon DDE_1 PF03184.19 KII64286.1 - 2e-13 50.4 1.8 3.8e-11 43.0 1.8 2.3 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF3792 PF12670.7 KII64287.1 - 0.026 14.7 2.9 0.04 14.1 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) Use1 PF09753.9 KII64287.1 - 0.057 13.1 1.3 0.09 12.5 1.3 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF588 PF04535.12 KII64287.1 - 0.064 13.0 1.4 0.091 12.5 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF588) Staphopain_pro PF14731.6 KII64287.1 - 3.4 7.6 8.6 1.2 9.1 2.9 2.2 1 1 0 2 2 2 0 Staphopain proregion CCSMST1 PF15013.6 KII64288.1 - 0.0023 18.0 0.1 0.0048 17.0 0.1 1.5 1 0 0 1 1 1 1 CCSMST1 family FixP_N PF14715.6 KII64288.1 - 2.5 7.9 4.6 4.8 7.0 4.6 1.4 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP DUF3149 PF11346.8 KII64288.1 - 5 6.8 7.4 1.7 8.3 4.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) Orf78 PF06024.12 KII64290.1 - 0.056 13.7 0.6 0.056 13.7 0.6 1.5 1 1 1 2 2 2 0 Orf78 (ac78) DUF3671 PF12420.8 KII64290.1 - 0.22 11.6 4.7 0.35 10.9 4.6 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF5001 PF16392.5 KII64291.1 - 0.095 12.6 0.6 26 4.8 0.0 3.1 3 0 0 3 3 3 0 Ig-like domain HTH_Tnp_Tc3_2 PF01498.18 KII64293.1 - 0.013 15.7 0.2 0.024 14.9 0.2 1.6 1 1 0 1 1 1 0 Transposase Arg_repressor PF01316.21 KII64293.1 - 0.06 13.1 0.2 0.15 11.8 0.2 1.6 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain ARL2_Bind_BART PF11527.8 KII64295.1 - 0.0017 18.5 1.6 0.0038 17.3 1.6 1.6 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART DUF3931 PF13082.6 KII64295.1 - 0.076 13.2 2.4 8.9 6.6 0.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3931) RMI2 PF16100.5 KII64296.1 - 3e-08 33.6 0.0 3.8e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 Ion_trans PF00520.31 KII64298.1 - 2.4e-07 30.2 0.4 2.4e-07 30.2 0.4 1.8 2 0 0 2 2 2 1 Ion transport protein GPHH PF16905.5 KII64300.1 - 1.5e-08 34.2 0.0 2.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated NOG1_N PF17835.1 KII64301.1 - 3.2e-52 176.7 1.9 6.1e-52 175.8 1.9 1.5 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOG1 PF06858.14 KII64301.1 - 7.3e-25 86.5 0.1 1.7e-24 85.3 0.1 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 KII64301.1 - 2.9e-17 62.8 0.0 9.9e-17 61.1 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase NOGCT PF08155.11 KII64301.1 - 2.4e-14 53.0 2.3 8.4e-14 51.3 2.3 2.0 1 0 0 1 1 1 1 NOGCT (NUC087) domain FeoB_N PF02421.18 KII64301.1 - 1.2e-10 41.1 0.0 2.7e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KII64301.1 - 0.0091 16.1 0.2 1.5 8.8 0.0 2.8 1 1 1 2 2 2 1 Dynamin family AIG1 PF04548.16 KII64301.1 - 0.02 14.2 0.1 0.064 12.6 0.0 2.0 2 0 0 2 2 2 0 AIG1 family RsgA_GTPase PF03193.16 KII64301.1 - 0.055 13.4 0.0 0.83 9.5 0.0 2.6 2 1 0 2 2 2 0 RsgA GTPase SNAP PF14938.6 KII64303.1 - 0.00012 21.7 0.1 0.00017 21.2 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF3300 PF11737.8 KII64303.1 - 0.059 12.9 0.9 2.7 7.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3300) SNAP PF14938.6 KII64304.1 - 1.5e-07 31.1 2.5 2.5e-07 30.4 2.2 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP zf-C2H2_jaz PF12171.8 KII64306.1 - 0.31 11.4 0.3 0.31 11.4 0.3 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KII64306.1 - 2.8 9.0 11.3 8.4 7.5 3.6 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 KII64306.1 - 5.7 7.5 9.4 8.2 7.0 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 KII64306.1 - 7.7 7.2 9.9 5.1 7.8 1.6 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type RVT_1 PF00078.27 KII64307.1 - 0.00021 20.9 0.4 0.0017 17.9 0.0 2.5 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2153 PF09921.9 KII64308.1 - 0.096 12.5 0.6 0.28 11.0 0.4 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) UPF0242 PF06785.11 KII64310.1 - 0.014 15.5 3.8 1.1 9.3 0.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Corona_S2 PF01601.16 KII64310.1 - 0.023 13.2 2.5 0.032 12.8 2.5 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Uds1 PF15456.6 KII64310.1 - 0.087 13.0 2.8 0.63 10.2 0.9 2.1 2 0 0 2 2 2 0 Up-regulated During Septation PepSY_like PF11396.8 KII64310.1 - 0.32 11.6 4.3 0.63 10.6 4.3 1.5 1 0 0 1 1 1 0 Putative beta-lactamase-inhibitor-like, PepSY-like FAM76 PF16046.5 KII64310.1 - 0.47 9.8 3.9 0.65 9.3 3.9 1.3 1 0 0 1 1 1 0 FAM76 protein SlyX PF04102.12 KII64310.1 - 1.3 9.7 3.5 36 5.1 0.3 2.5 2 0 0 2 2 2 0 SlyX DUF1664 PF07889.12 KII64310.1 - 2.4 8.2 5.3 2.1 8.4 2.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) RVT_1 PF00078.27 KII64311.1 - 1.9e-34 119.1 0.0 1.2e-33 116.5 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII64311.1 - 1.8e-05 25.2 0.0 4.2e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII64311.1 - 0.00012 22.4 0.0 0.00032 20.9 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII64311.1 - 0.0054 17.3 0.0 0.013 16.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A3 PF02160.15 KII64311.1 - 0.0071 15.9 3.4 0.2 11.1 1.4 2.4 2 0 0 2 2 2 1 Cauliflower mosaic virus peptidase (A3) Peptidase_A2B PF12384.8 KII64311.1 - 0.01 15.4 0.0 0.024 14.2 0.0 1.6 1 0 0 1 1 1 0 Ty3 transposon peptidase Peptidase_A2E PF12382.8 KII64311.1 - 0.01 15.9 0.1 0.039 14.0 0.1 2.0 1 0 0 1 1 1 0 Retrotransposon peptidase Asp_protease PF09668.10 KII64311.1 - 0.044 13.6 0.2 0.25 11.1 0.2 2.1 1 1 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 KII64311.1 - 0.48 10.6 4.9 0.18 11.9 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII64311.1 - 0.98 9.2 5.0 12 5.7 1.2 2.6 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.6 KII64312.1 - 1.4e-10 41.1 0.3 1.3e-09 38.0 0.3 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease PAP2_C PF14360.6 KII64313.1 - 1.1e-16 61.1 17.7 1.1e-16 61.1 17.7 2.7 2 1 1 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 KII64313.1 - 0.0089 15.8 16.5 0.0089 15.8 16.5 1.9 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KII64313.1 - 0.56 9.9 20.9 1.2 8.8 20.9 1.6 1 1 0 1 1 1 0 PAP2 superfamily CDC50 PF03381.15 KII64314.1 - 2.2e-08 34.0 0.2 3.4e-08 33.3 0.2 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family IP_trans PF02121.18 KII64315.1 - 2.8e-87 292.4 0.1 3.3e-87 292.2 0.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein RIB43A PF05914.12 KII64315.1 - 0.11 11.2 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 RIB43A Smg4_UPF3 PF03467.15 KII64317.1 - 3.8e-11 43.3 2.6 7.3e-11 42.4 2.6 1.6 1 1 0 1 1 1 1 Smg-4/UPF3 family RRM_1 PF00076.22 KII64317.1 - 0.036 13.9 0.0 0.072 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHD PF00628.29 KII64318.1 - 2.2e-15 56.2 23.4 7.6e-11 41.7 4.4 2.5 2 0 0 2 2 2 2 PHD-finger PHD_2 PF13831.6 KII64318.1 - 0.0083 15.7 20.4 0.034 13.7 0.9 3.5 3 1 1 4 4 4 2 PHD-finger C1_2 PF03107.16 KII64318.1 - 0.025 14.9 2.6 0.025 14.9 2.6 3.7 4 1 0 4 4 4 0 C1 domain NPDC1 PF06809.11 KII64318.1 - 0.026 13.6 2.7 0.03 13.4 2.1 1.3 1 1 0 1 1 1 0 Neural proliferation differentiation control-1 protein (NPDC1) zf-RanBP PF00641.18 KII64318.1 - 0.036 13.4 0.2 0.036 13.4 0.2 3.9 4 0 0 4 4 4 0 Zn-finger in Ran binding protein and others PolC_DP2 PF03833.13 KII64318.1 - 0.97 7.2 14.8 0.079 10.8 9.2 1.7 1 1 1 2 2 2 0 DNA polymerase II large subunit DP2 Zf_RING PF16744.5 KII64318.1 - 5.4 7.2 24.4 1.5 9.0 7.1 3.7 1 1 2 3 3 3 0 KIAA1045 RING finger SNF2_N PF00176.23 KII64319.1 - 5.6e-55 186.5 0.1 9.6e-55 185.7 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KII64319.1 - 2.2e-20 73.0 0.4 8.7e-20 71.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII64319.1 - 4.5e-09 36.5 0.0 1.5e-06 28.4 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Chromo PF00385.24 KII64319.1 - 1.7e-08 34.3 0.1 5e-08 32.7 0.1 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DEAD PF00270.29 KII64319.1 - 0.014 15.2 0.0 2.7 7.7 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_22 PF13401.6 KII64319.1 - 0.018 15.3 0.2 0.088 13.1 0.0 2.3 3 0 0 3 3 3 0 AAA domain SWI2_SNF2 PF18766.1 KII64319.1 - 0.12 12.1 0.1 0.32 10.6 0.0 1.7 2 0 0 2 2 2 0 SWI2/SNF2 ATPase CHDCT2 PF08074.11 KII64320.1 - 2e-22 80.2 0.3 2e-22 80.2 0.3 1.8 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain DUF1087 PF06465.13 KII64320.1 - 3.3e-12 46.3 0.9 6.6e-12 45.3 0.9 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1087) DUF1086 PF06461.11 KII64320.1 - 0.028 14.3 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) SnAC PF14619.6 KII64320.1 - 0.039 14.6 0.7 0.039 14.6 0.7 2.1 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex Xpo1 PF08389.12 KII64320.1 - 0.044 13.8 0.6 0.084 12.9 0.6 1.4 1 0 0 1 1 1 0 Exportin 1-like protein DHR-2 PF06920.13 KII64321.1 - 1.6e-32 112.9 0.9 2.9e-32 112.0 0.9 1.4 1 0 0 1 1 1 1 Dock homology region 2 DOCK_N PF16172.5 KII64324.1 - 2.6e-07 29.9 0.0 4.6e-07 29.1 0.0 1.4 1 1 0 1 1 1 1 DOCK N-terminus DUF5506 PF17611.2 KII64325.1 - 0.02 14.8 0.1 1.5 8.7 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5506) Longin PF13774.6 KII64325.1 - 0.052 13.6 0.0 0.091 12.8 0.0 1.7 1 1 0 1 1 1 0 Regulated-SNARE-like domain Ldl_recept_a PF00057.18 KII64326.1 - 5e-08 33.0 10.5 1.7e-07 31.3 10.5 2.0 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Chondroitinas_B PF14592.6 KII64326.1 - 0.024 13.5 0.3 0.049 12.5 0.0 1.6 2 0 0 2 2 2 0 Chondroitinase B Sortilin_C PF15901.5 KII64327.1 - 2e-17 64.0 2.1 2.8e-17 63.6 2.1 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal E1_DerP2_DerF2 PF02221.15 KII64329.1 - 3e-07 31.0 0.0 3.6e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 ML domain Ldl_recept_a PF00057.18 KII64331.1 - 2.6e-35 120.3 102.8 1.5e-11 44.3 7.7 7.0 6 1 1 7 7 7 6 Low-density lipoprotein receptor domain class A HTH_Tnp_IS630 PF01710.16 KII64332.1 - 1.6e-05 24.9 0.2 1.8e-05 24.8 0.2 1.1 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 KII64332.1 - 2.4e-05 24.0 0.0 0.00036 20.3 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.18 KII64332.1 - 0.00012 22.0 0.0 0.00015 21.7 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.6 KII64332.1 - 0.00016 21.5 0.1 0.016 15.1 0.0 2.3 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 KII64332.1 - 0.00063 19.2 0.1 0.025 14.1 0.0 2.6 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 KII64332.1 - 0.00096 19.2 0.0 0.009 16.1 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_33 PF13592.6 KII64332.1 - 0.0012 18.4 0.0 0.0031 17.1 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 KII64332.1 - 0.01 16.4 0.0 0.016 15.8 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII64332.1 - 0.017 15.3 1.2 0.033 14.4 0.7 1.7 2 0 0 2 2 2 0 Transposase Arg_repressor PF01316.21 KII64332.1 - 0.069 12.9 0.5 0.13 12.1 0.5 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_29 PF13551.6 KII64332.1 - 0.12 12.4 0.0 0.66 10.1 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn helix DUF3794 PF12673.7 KII64333.1 - 0.0079 16.5 0.0 0.41 11.0 0.0 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF3794) Rhabdo_ncap_2 PF03216.13 KII64333.1 - 0.11 11.9 0.6 1.1 8.7 0.1 2.0 1 1 1 2 2 2 0 Rhabdovirus nucleoprotein Topo_C_assoc PF14370.6 KII64333.1 - 0.12 12.4 0.2 19 5.3 0.0 2.5 1 1 1 2 2 2 0 C-terminal topoisomerase domain KRE1 PF17056.5 KII64333.1 - 0.39 10.5 1.7 11 5.8 0.1 2.9 1 1 2 3 3 3 0 Killer toxin-resistance protein 1 DUF1981 PF09324.10 KII64334.1 - 0.11 12.3 0.2 0.49 10.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) EcoRI_methylase PF13651.6 KII64335.1 - 0.033 13.4 0.0 0.042 13.1 0.0 1.1 1 0 0 1 1 1 0 Adenine-specific methyltransferase EcoRI FLYWCH PF04500.16 KII64336.1 - 2.4e-08 34.0 1.2 4e-08 33.2 1.2 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain WRKY PF03106.15 KII64336.1 - 0.079 13.2 1.6 0.17 12.2 1.6 1.6 1 0 0 1 1 1 0 WRKY DNA -binding domain DDE_Tnp_IS1595 PF12762.7 KII64339.1 - 7e-07 29.4 0.5 1.1e-06 28.8 0.5 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Spuma_A9PTase PF03539.14 KII64339.1 - 0.0047 17.1 0.2 0.013 15.7 0.0 1.8 2 0 0 2 2 2 1 Spumavirus aspartic protease (A9) Mob1_phocein PF03637.17 KII64339.1 - 0.041 13.9 1.6 0.066 13.2 1.6 1.3 1 0 0 1 1 1 0 Mob1/phocein family Sortilin_C PF15901.5 KII64342.1 - 3.2e-15 56.9 2.6 3.2e-15 56.9 2.6 1.7 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Ldl_recept_a PF00057.18 KII64342.1 - 3e-06 27.4 11.8 3e-06 27.4 11.8 3.7 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII64342.1 - 3.6e-06 26.0 0.4 0.00015 20.7 0.0 3.0 3 0 0 3 3 3 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII64343.1 - 1.4e-07 32.0 0.0 1.7e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII64343.1 - 0.016 14.0 0.1 0.022 13.6 0.1 1.1 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, DUF2572 PF10833.8 KII64344.1 - 0.06 13.1 0.4 1.2 8.9 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2572) DDE_3 PF13358.6 KII64348.1 - 8.5e-09 35.3 0.0 1.1e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease EGF_2 PF07974.13 KII64352.1 - 0.0015 18.8 33.7 0.0071 16.7 0.6 3.9 3 1 0 3 3 3 3 EGF-like domain EGF PF00008.27 KII64352.1 - 0.9 9.9 28.5 0.22 11.9 3.4 4.7 3 1 0 3 3 3 0 EGF-like domain zf-CCHC PF00098.23 KII64353.1 - 0.0018 18.3 1.9 0.0018 18.3 1.9 1.6 2 0 0 2 2 2 1 Zinc knuckle His_Phos_2 PF00328.22 KII64353.1 - 0.023 14.1 0.3 0.025 13.9 0.3 1.0 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) YqgF PF14639.6 KII64353.1 - 0.097 12.4 0.0 0.24 11.2 0.0 1.6 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 NAP PF00956.18 KII64354.1 - 3.6e-53 180.5 6.8 4.4e-53 180.2 6.8 1.0 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) DUF2653 PF10850.8 KII64354.1 - 0.043 14.0 0.5 0.18 12.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2653) RasGEF PF00617.19 KII64355.1 - 1.4e-25 90.5 0.1 1.7e-25 90.2 0.1 1.2 1 1 0 1 1 1 1 RasGEF domain DUF1229 PF06797.11 KII64355.1 - 0.011 15.9 0.3 0.018 15.2 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1229) RVT_1 PF00078.27 KII64356.1 - 2.4e-06 27.2 0.1 4e-06 26.5 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HSP20 PF00011.21 KII64358.1 - 7e-19 67.9 1.1 1.7e-08 34.5 0.2 2.2 2 0 0 2 2 2 2 Hsp20/alpha crystallin family YabP PF07873.11 KII64358.1 - 5.4e-05 22.9 0.1 0.00021 21.0 0.1 2.1 1 0 0 1 1 1 1 YabP family ArsA_HSP20 PF17886.1 KII64358.1 - 0.003 17.1 0.1 0.64 9.6 0.0 2.7 2 1 0 2 2 2 2 HSP20-like domain found in ArsA CS PF04969.16 KII64358.1 - 0.0032 18.4 7.1 0.21 12.6 0.3 3.7 2 1 0 3 3 3 2 CS domain Integrase_H2C2 PF17921.1 KII64359.1 - 4.8e-07 29.8 0.1 1e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain PND PF17949.1 KII64360.1 - 0.052 13.8 0.2 0.13 12.5 0.0 1.8 2 0 0 2 2 2 0 FANCM pseudonuclease domain WRC PF08879.10 KII64360.1 - 0.38 10.5 3.9 9.2 6.1 0.2 2.4 2 0 0 2 2 2 0 WRC DnaJ PF00226.31 KII64361.1 - 9.7e-24 83.3 0.6 2.6e-23 81.9 0.6 1.8 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.11 KII64361.1 - 9.5e-18 64.4 0.3 9.5e-18 64.4 0.3 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DLP_helical PF18709.1 KII64361.1 - 0.086 12.0 4.3 0.14 11.4 4.3 1.2 1 0 0 1 1 1 0 Dynamin-like helical domain Lipoprotein_3 PF00938.17 KII64361.1 - 0.098 12.9 1.5 0.21 11.8 0.2 2.1 1 1 1 2 2 2 0 Lipoprotein RPN1_RPN2_N PF17781.1 KII64362.1 - 1.2e-50 172.7 5.2 2e-50 171.9 5.2 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 KII64362.1 - 9.7e-26 89.6 0.1 1.8e-25 88.7 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 KII64362.1 - 1.7e-19 69.2 5.5 0.005 17.2 0.1 7.5 6 0 0 6 6 6 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KII64362.1 - 9.5e-05 22.7 0.1 0.048 14.0 0.0 3.2 3 0 0 3 3 3 1 HEAT repeats Band_7_C PF16200.5 KII64362.1 - 0.13 12.3 0.0 0.46 10.6 0.0 1.9 2 0 0 2 2 2 0 C-terminal region of band_7 TnpV PF14198.6 KII64362.1 - 0.38 10.8 6.4 0.48 10.4 0.2 2.7 2 0 0 2 2 2 0 Transposon-encoded protein TnpV DUF496 PF04363.12 KII64362.1 - 1.7 8.7 8.1 1.2 9.2 3.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF496) DUF3800 PF12686.7 KII64362.1 - 3.6 8.2 6.4 1.7 9.3 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) Spectrin PF00435.21 KII64362.1 - 6.7 7.3 7.8 1.1 9.8 3.6 1.9 2 0 0 2 2 2 0 Spectrin repeat Vfa1 PF08432.10 KII64362.1 - 8 6.7 9.2 15 5.9 9.2 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1804 PF08822.11 KII64363.1 - 0.031 14.3 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) OSCP PF00213.18 KII64363.1 - 0.091 12.9 0.9 3.7 7.6 0.1 2.1 1 1 1 2 2 2 0 ATP synthase delta (OSCP) subunit AI-2E_transport PF01594.16 KII64363.1 - 0.25 10.4 0.9 0.31 10.1 0.9 1.1 1 0 0 1 1 1 0 AI-2E family transporter DUF2396 PF09654.10 KII64364.1 - 0.047 13.8 0.1 0.06 13.5 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2396) Evr1_Alr PF04777.13 KII64364.1 - 0.083 13.4 1.7 9.5 6.8 0.1 2.3 1 1 1 2 2 2 0 Erv1 / Alr family C1_1 PF00130.22 KII64364.1 - 0.16 11.9 0.2 0.16 11.9 0.2 2.5 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_SprT PF17283.2 KII64364.1 - 2.4 8.1 9.3 73 3.4 5.0 3.5 3 1 0 3 3 3 0 SprT-like zinc ribbon domain DUF5038 PF16441.5 KII64365.1 - 0.0079 16.2 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5038) RRT14 PF17075.5 KII64365.1 - 0.011 15.9 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 Fe_dep_repress PF01325.19 KII64365.1 - 0.074 13.3 0.1 0.38 11.0 0.0 2.2 3 0 0 3 3 3 0 Iron dependent repressor, N-terminal DNA binding domain Tim44 PF04280.15 KII64365.1 - 0.17 12.0 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Tim44-like domain PLDc_2 PF13091.6 KII64366.1 - 4e-19 68.8 0.2 5.9e-19 68.3 0.2 1.3 1 0 0 1 1 1 1 PLD-like domain DUF1173 PF06666.11 KII64366.1 - 2.7e-13 49.6 0.0 3.7e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1173) FAM83 PF07894.12 KII64366.1 - 6.9e-05 22.5 0.0 0.079 12.5 0.0 2.1 1 1 1 2 2 2 2 FAM83 A-H DUF790 PF05626.11 KII64366.1 - 0.007 15.1 0.0 0.008 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF790) Exo_endo_phos PF03372.23 KII64366.1 - 0.092 12.2 0.0 0.099 12.1 0.0 1.1 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Acetyltransf_1 PF00583.25 KII64368.1 - 6.3e-15 55.4 0.0 7.9e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KII64368.1 - 1.6e-07 31.7 0.0 2.4e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KII64368.1 - 5.7e-06 26.3 0.0 7.3e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KII64368.1 - 7.8e-06 25.8 0.0 2.5e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.6 KII64368.1 - 0.00085 19.4 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase NAT PF04768.13 KII64368.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 NAT, N-acetyltransferase, of N-acetylglutamate synthase tRNA-synt_1g PF09334.11 KII64369.1 - 1.3e-08 34.1 0.1 1.6e-08 33.7 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KII64369.1 - 8.4e-06 24.3 0.0 1.1e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) K_oxygenase PF13434.6 KII64370.1 - 1.8e-89 300.3 0.3 2.1e-89 300.0 0.3 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 KII64370.1 - 1.1e-12 47.8 0.1 3.1e-11 43.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KII64370.1 - 8.6e-06 25.2 0.0 0.00014 21.2 0.0 2.1 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NIPSNAP PF07978.13 KII64371.1 - 0.00041 20.5 0.0 0.00045 20.4 0.0 1.0 1 0 0 1 1 1 1 NIPSNAP HEPN PF05168.14 KII64372.1 - 0.0039 17.3 0.1 0.0074 16.4 0.1 1.6 1 1 0 1 1 1 1 HEPN domain HEPN_Apea PF18739.1 KII64372.1 - 0.016 15.7 0.1 0.029 14.8 0.1 1.4 1 0 0 1 1 1 0 Apea-like HEPN Prok-RING_1 PF14446.6 KII64372.1 - 2.7 8.0 11.1 0.26 11.3 3.4 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Toxin_17 PF08086.11 KII64372.1 - 6.6 7.1 8.6 0.86 9.9 0.8 2.8 2 1 0 2 2 2 0 Ergtoxin family Adenyl_transf PF04439.12 KII64373.1 - 0.13 11.3 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Streptomycin adenylyltransferase zf_CCCH_4 PF18345.1 KII64373.1 - 6.1 7.0 5.6 36 4.6 0.0 2.7 3 0 0 3 3 3 0 Zinc finger domain SMC_N PF02463.19 KII64374.1 - 4.7e-09 36.0 0.0 5.1e-08 32.6 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KII64374.1 - 1.6e-08 34.8 0.6 0.00038 20.4 0.1 2.4 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KII64374.1 - 1.5e-06 28.9 1.2 8.5e-06 26.4 1.3 2.1 1 1 0 1 1 1 1 AAA domain PHP_C PF13263.6 KII64374.1 - 0.00091 18.9 0.0 0.0024 17.6 0.0 1.7 1 0 0 1 1 1 1 PHP-associated AAA_15 PF13175.6 KII64374.1 - 0.0013 18.5 0.0 0.0079 15.9 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 KII64374.1 - 0.0046 16.7 0.0 0.015 15.0 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 KII64374.1 - 0.0087 16.6 0.0 0.034 14.7 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 KII64374.1 - 0.022 15.2 0.3 0.17 12.3 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain DUF3800 PF12686.7 KII64375.1 - 0.00015 22.4 0.0 0.00024 21.7 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3800) MarR_2 PF12802.7 KII64377.1 - 0.0059 16.5 0.0 0.017 15.0 0.0 1.7 2 0 0 2 2 2 1 MarR family HTH_11 PF08279.12 KII64377.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 HTH domain AbiEii PF08843.11 KII64378.1 - 0.091 12.7 0.0 0.68 9.8 0.0 2.2 1 1 0 1 1 1 0 Nucleotidyl transferase AbiEii toxin, Type IV TA system Phage_integrase PF00589.22 KII64380.1 - 1.9e-41 141.7 0.0 2.3e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family Crr6 PF08847.11 KII64380.1 - 0.077 12.7 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Chlororespiratory reduction 6 HTH_31 PF13560.6 KII64381.1 - 0.053 13.9 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_19 PF12844.7 KII64381.1 - 0.15 12.1 0.0 0.39 10.8 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Sortilin-Vps10 PF15902.5 KII64382.1 - 1.2e-11 44.1 2.7 2.9e-07 29.7 0.8 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII64382.1 - 1e-07 30.9 0.6 0.45 10.7 0.0 3.8 3 0 0 3 3 3 3 BNR/Asp-box repeat Sortilin_C PF15901.5 KII64382.1 - 1.3e-05 25.6 0.1 2.6e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin_C PF15901.5 KII64384.1 - 1.9e-15 57.6 6.0 2.5e-15 57.2 6.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII64384.1 - 3.9e-08 32.5 0.4 7.3e-08 31.6 0.4 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII64384.1 - 0.097 12.7 0.1 0.097 12.7 0.1 3.4 4 0 0 4 4 4 0 BNR/Asp-box repeat Sortilin_C PF15901.5 KII64385.1 - 5.1e-16 59.5 0.6 5.1e-16 59.5 0.6 1.6 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII64385.1 - 0.001 18.0 0.5 0.063 12.1 0.2 2.6 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII64385.1 - 0.0034 17.2 4.5 0.11 12.6 0.1 3.9 4 0 0 4 4 4 1 BNR/Asp-box repeat Sortilin_C PF15901.5 KII64387.1 - 2.5e-05 24.7 0.0 6e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII64387.1 - 0.00014 21.4 1.4 2.7 8.3 0.1 4.2 3 0 0 3 3 3 2 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII64387.1 - 0.0056 15.5 3.9 0.011 14.5 0.2 2.7 2 2 1 3 3 3 1 Sortilin, neurotensin receptor 3, Mso1_Sec1_bdg PF14475.6 KII64387.1 - 0.11 12.1 0.4 0.27 10.8 0.4 1.6 1 0 0 1 1 1 0 Sec1-binding region of Mso1 rve PF00665.26 KII64390.1 - 8.3e-21 74.4 0.0 1.6e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64390.1 - 5.9e-18 64.7 0.6 1.4e-17 63.6 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 KII64390.1 - 0.0023 18.2 0.0 0.0052 17.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF5086 PF16985.5 KII64390.1 - 0.014 15.3 0.1 0.4 10.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5086) TrbM PF07424.11 KII64390.1 - 0.086 12.8 0.5 0.75 9.7 0.0 2.1 2 0 0 2 2 2 0 TrbM RT_RNaseH_2 PF17919.1 KII64391.1 - 2.5e-26 91.6 0.0 5.3e-26 90.6 0.0 1.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64391.1 - 3.3e-15 56.3 0.0 6.7e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DNA_ligase_A_C PF04679.15 KII64392.1 - 3e-10 40.6 0.1 4.5e-10 40.0 0.1 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region 7tm_1 PF00001.21 KII64393.1 - 7e-15 55.1 21.4 1.5e-14 53.9 21.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF848 PF05852.11 KII64395.1 - 0.0032 17.6 1.8 0.0048 17.0 1.0 1.7 2 0 0 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) zf-met PF12874.7 KII64395.1 - 0.0063 16.9 2.1 0.015 15.6 2.1 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 KII64395.1 - 0.0066 16.8 3.7 0.013 16.0 3.7 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 KII64395.1 - 0.015 15.6 0.4 0.032 14.6 0.2 1.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KII64395.1 - 0.068 13.5 3.0 0.13 12.5 3.0 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KII64395.1 - 0.11 13.4 1.6 0.26 12.2 1.6 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger HPHLAWLY PF14925.6 KII64396.1 - 0.0087 14.8 0.2 0.01 14.6 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF1108 PF06531.11 KII64397.1 - 0.02 15.2 1.6 0.041 14.2 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) DUF4268 PF14088.6 KII64397.1 - 0.024 14.5 1.2 0.034 14.0 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4268) BRO1 PF03097.18 KII64398.1 - 0.026 13.4 0.8 0.099 11.4 0.1 1.8 1 1 1 2 2 2 0 BRO1-like domain Abhydrolase_3 PF07859.13 KII64399.1 - 6.7e-42 143.7 0.0 8.8e-29 100.9 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold HSL_N PF06350.12 KII64399.1 - 9.1e-14 51.1 0.2 1.3e-13 50.6 0.2 1.2 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus Say1_Mug180 PF10340.9 KII64399.1 - 1.1e-08 34.4 0.0 1.7e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase DLH PF01738.18 KII64399.1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family HgmA PF04209.13 KII64400.1 - 0.06 12.0 0.1 0.079 11.7 0.1 1.1 1 0 0 1 1 1 0 homogentisate 1,2-dioxygenase 7TM-7TMR_HD PF07698.11 KII64401.1 - 0.0086 15.9 9.6 0.011 15.5 9.6 1.1 1 0 0 1 1 1 1 7TM receptor with intracellular HD hydrolase DuoxA PF10204.9 KII64401.1 - 3.6 6.5 11.8 25 3.8 12.0 1.9 1 1 1 2 2 2 0 Dual oxidase maturation factor DHHC PF01529.20 KII64402.1 - 1.3e-13 51.2 7.9 1.8e-13 50.8 7.9 1.5 1 1 0 1 1 1 1 DHHC palmitoyltransferase E2F_TDP PF02319.20 KII64404.1 - 8.9e-23 80.1 0.1 2e-22 79.0 0.0 1.6 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain E2F_CC-MB PF16421.5 KII64404.1 - 5.9e-10 39.4 0.0 1.4e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain B-block_TFIIIC PF04182.12 KII64404.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Usp PF00582.26 KII64405.1 - 2.2e-07 31.4 0.0 5.8e-07 30.1 0.0 1.7 1 1 0 1 1 1 1 Universal stress protein family Staph_opine_DH PF10100.9 KII64405.1 - 0.035 12.7 0.0 0.041 12.5 0.0 1.1 1 0 0 1 1 1 0 Staphylopine dehydrogenase ORF45 PF17620.2 KII64407.1 - 0.011 15.8 3.2 0.11 12.6 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function DUF5568 PF17724.1 KII64407.1 - 1.2 8.9 4.5 0.3 10.9 0.3 2.0 2 1 0 2 2 2 0 Family of unknown function (DUF5568) Carb_anhydrase PF00194.21 KII64408.1 - 5.8e-21 75.2 0.0 6.6e-21 75.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 KII64409.1 - 1.4e-20 73.9 0.0 1.4e-20 73.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Kelch_4 PF13418.6 KII64410.1 - 0.059 13.4 0.1 0.079 13.0 0.1 1.3 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_1 PF01344.25 KII64410.1 - 0.1 12.2 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Kelch motif PH PF00169.29 KII64414.1 - 0.053 14.0 0.6 0.086 13.4 0.6 1.5 1 1 0 1 1 1 0 PH domain Rhodanese PF00581.20 KII64415.1 - 0.015 15.8 0.1 0.023 15.2 0.1 1.3 1 1 0 1 1 1 0 Rhodanese-like domain PWWP PF00855.17 KII64417.1 - 0.09 13.2 0.0 0.14 12.5 0.0 1.6 1 1 0 1 1 1 0 PWWP domain Tom37_C PF11801.8 KII64418.1 - 0.079 12.9 0.2 0.17 11.9 0.0 1.6 2 0 0 2 2 2 0 Tom37 C-terminal domain zf-UBR PF02207.20 KII64419.1 - 1.2e-07 31.8 2.5 1.2e-07 31.8 2.5 2.5 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ATP_bind_1 PF03029.17 KII64419.1 - 0.051 13.3 0.1 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Ras PF00071.22 KII64422.1 - 2.3e-36 124.9 0.3 2.9e-36 124.5 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII64422.1 - 1.2e-17 64.2 0.0 2.2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII64422.1 - 3.7e-13 49.3 0.2 8.6e-13 48.1 0.1 1.6 1 1 1 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KII64422.1 - 2.7e-05 23.8 1.1 7.7e-05 22.3 0.4 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KII64422.1 - 0.00013 22.0 0.0 0.00023 21.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KII64422.1 - 0.00013 21.5 0.1 0.00018 21.0 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 KII64422.1 - 0.00017 21.5 0.5 0.47 10.3 0.1 2.5 1 1 0 2 2 2 2 RsgA GTPase Viral_helicase1 PF01443.18 KII64422.1 - 0.0017 18.1 0.0 0.0024 17.7 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase FeoB_N PF02421.18 KII64422.1 - 0.015 14.9 0.2 1.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_16 PF13191.6 KII64422.1 - 0.016 15.6 0.0 0.016 15.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 KII64422.1 - 0.018 14.6 0.0 0.034 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 KII64422.1 - 0.027 14.2 1.7 0.056 13.2 1.7 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KII64422.1 - 0.036 14.3 0.0 0.067 13.4 0.0 1.5 2 0 0 2 2 2 0 AAA domain sCache_2 PF17200.4 KII64422.1 - 0.037 13.9 0.0 0.057 13.3 0.0 1.2 1 0 0 1 1 1 0 Single Cache domain 2 SMODS PF18144.1 KII64422.1 - 0.038 14.2 0.1 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Lsr2 PF11774.8 KII64422.1 - 0.051 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Lsr2 MeaB PF03308.16 KII64422.1 - 0.077 12.0 0.0 7.9 5.4 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 KII64422.1 - 0.096 11.9 1.9 0.76 8.9 0.3 2.2 2 1 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.6 KII64422.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KII64422.1 - 0.15 12.3 0.2 0.5 10.6 0.1 2.0 2 1 0 2 2 2 0 AAA domain DDE_3 PF13358.6 KII64423.1 - 0.0023 17.7 0.0 0.095 12.5 0.0 2.4 1 1 0 1 1 1 1 DDE superfamily endonuclease TssC PF17541.2 KII64423.1 - 0.066 12.0 0.1 0.12 11.2 0.1 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB Sec10 PF07393.11 KII64425.1 - 0.0018 16.8 2.1 0.0019 16.7 2.1 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 PTPA PF03095.15 KII64425.1 - 0.0019 17.7 0.8 0.0022 17.5 0.8 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Cep57_MT_bd PF06657.13 KII64425.1 - 0.0026 18.2 3.7 0.0034 17.8 0.8 2.2 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 DUF948 PF06103.11 KII64425.1 - 0.0059 16.8 1.8 0.6 10.4 0.2 2.1 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) bZIP_1 PF00170.21 KII64425.1 - 0.0097 16.0 3.6 0.0097 16.0 3.6 2.6 2 1 1 3 3 3 1 bZIP transcription factor Elf4 PF07011.11 KII64425.1 - 0.014 15.3 6.1 0.14 12.1 0.6 2.5 1 1 0 2 2 2 0 Early Flowering 4 domain DUF5595 PF18077.1 KII64425.1 - 0.014 15.4 7.3 0.014 15.4 7.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) GAS PF13851.6 KII64425.1 - 0.018 14.4 13.1 0.097 12.0 5.5 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2704 PF10866.8 KII64425.1 - 0.028 14.3 1.7 0.034 14.0 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2704) PRKG1_interact PF15898.5 KII64425.1 - 0.031 15.2 8.7 0.038 14.9 8.7 1.1 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Importin_rep_6 PF18829.1 KII64425.1 - 0.032 14.4 0.6 0.055 13.6 0.5 1.5 1 1 0 1 1 1 0 Importin repeat 6 AAA_32 PF13654.6 KII64425.1 - 0.047 12.5 7.7 0.052 12.3 7.7 1.0 1 0 0 1 1 1 0 AAA domain Peptidase_M9_N PF08453.10 KII64425.1 - 0.058 13.1 0.3 0.12 12.0 0.2 1.7 1 1 0 1 1 1 0 Peptidase family M9 N-terminal BRE1 PF08647.11 KII64425.1 - 0.059 13.5 10.9 0.4 10.8 1.8 2.7 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase RNA_pol_Rpb2_1 PF04563.15 KII64425.1 - 0.059 12.9 0.4 0.09 12.3 0.3 1.3 1 1 0 1 1 1 0 RNA polymerase beta subunit Helo_like_N PF17111.5 KII64425.1 - 0.07 12.5 5.0 0.094 12.1 5.0 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins ELFV_dehydrog PF00208.21 KII64425.1 - 0.077 12.7 0.1 0.094 12.4 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase YojJ PF10372.9 KII64425.1 - 0.081 13.0 5.6 0.066 13.3 3.5 1.9 1 1 1 2 2 2 0 Bacterial membrane-spanning protein N-terminus Snapin_Pallidin PF14712.6 KII64425.1 - 0.089 13.2 9.1 0.16 12.4 0.8 2.3 2 0 0 2 2 2 0 Snapin/Pallidin DUF1664 PF07889.12 KII64425.1 - 0.14 12.2 5.0 3.6 7.6 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Ribonucleas_3_2 PF11469.8 KII64425.1 - 0.14 12.5 1.5 9.3 6.7 0.0 2.1 1 1 1 2 2 2 0 Ribonuclease III DUF3958 PF13125.6 KII64425.1 - 0.15 12.3 11.4 0.2 11.9 11.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) STAT_alpha PF01017.20 KII64425.1 - 0.16 11.9 7.2 0.2 11.5 7.2 1.3 1 0 0 1 1 1 0 STAT protein, all-alpha domain Fib_alpha PF08702.10 KII64425.1 - 0.19 11.9 8.8 1.2 9.3 2.4 1.9 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4296 PF14129.6 KII64425.1 - 0.19 12.3 3.3 7.3 7.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) Baculo_PEP_C PF04513.12 KII64425.1 - 0.2 11.7 4.4 0.31 11.1 2.2 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.7 KII64425.1 - 0.4 11.3 4.3 0.45 11.1 1.9 2.0 1 1 1 2 2 2 0 YtxH-like protein Cut12 PF11500.8 KII64425.1 - 0.49 10.3 8.8 6.1 6.8 0.1 2.1 2 0 0 2 2 2 0 Spindle pole body formation-associated protein DUF4446 PF14584.6 KII64425.1 - 0.54 10.2 8.8 0.12 12.4 3.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) V_ATPase_I PF01496.19 KII64425.1 - 0.54 8.1 6.0 0.65 7.9 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF349 PF03993.12 KII64425.1 - 0.59 10.5 7.8 0.41 11.0 4.8 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) ADIP PF11559.8 KII64425.1 - 0.71 9.9 13.4 3.9 7.5 6.1 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding AAA_23 PF13476.6 KII64425.1 - 0.76 10.2 15.4 0.93 10.0 15.4 1.0 1 0 0 1 1 1 0 AAA domain TetR_C_37 PF18665.1 KII64425.1 - 0.84 10.3 8.6 0.41 11.3 3.8 2.1 1 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain KLRAQ PF10205.9 KII64425.1 - 1.2 9.4 12.6 0.44 10.8 6.3 2.0 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein CorA PF01544.18 KII64425.1 - 1.2 8.3 5.6 2.1 7.6 5.6 1.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein UPF0449 PF15136.6 KII64425.1 - 1.5 9.4 7.3 0.68 10.4 4.7 1.7 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Latarcin PF10279.9 KII64425.1 - 1.5 9.2 7.8 4.4 7.8 1.9 2.5 1 1 1 2 2 2 0 Latarcin precursor HALZ PF02183.18 KII64425.1 - 1.6 9.0 8.4 0.4 10.9 3.8 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper CENP-H PF05837.12 KII64425.1 - 3.6 8.0 10.5 1.8 9.0 3.2 2.2 1 1 0 2 2 2 0 Centromere protein H (CENP-H) LMBR1 PF04791.16 KII64425.1 - 3.7 6.3 5.0 4.8 6.0 5.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF16 PF01519.16 KII64425.1 - 4.5 7.8 13.0 6.3 7.3 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 YabA PF06156.13 KII64425.1 - 9 7.0 9.4 2.3 8.9 4.3 2.0 1 1 0 2 2 2 0 Initiation control protein YabA PurA PF04845.13 KII64426.1 - 8.3e-08 31.8 0.6 0.00074 18.9 0.1 2.1 1 1 1 2 2 2 2 PurA ssDNA and RNA-binding protein ALO PF04030.14 KII64426.1 - 0.032 14.1 0.1 0.066 13.0 0.0 1.5 2 0 0 2 2 2 0 D-arabinono-1,4-lactone oxidase HEPN_LA2681 PF18733.1 KII64427.1 - 0.0062 15.9 0.3 0.007 15.7 0.3 1.2 1 0 0 1 1 1 1 LA2681-like HEPN zf-CCHC PF00098.23 KII64429.1 - 0.00018 21.4 0.9 0.00036 20.5 0.9 1.5 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 KII64429.1 - 0.0099 16.5 0.0 0.014 16.0 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC_4 PF14392.6 KII64429.1 - 0.017 14.8 1.1 0.032 14.0 1.1 1.4 1 0 0 1 1 1 0 Zinc knuckle gag-asp_proteas PF13975.6 KII64429.1 - 0.13 12.9 0.0 0.2 12.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-C5HC2 PF02928.16 KII64429.1 - 0.82 10.1 8.7 0.27 11.6 5.2 2.0 2 1 0 2 2 2 0 C5HC2 zinc finger Perm-CXXC PF15629.6 KII64429.1 - 7.9 6.9 7.8 3.3 8.1 0.5 2.6 3 0 0 3 3 3 0 Permuted single zf-CXXC unit Tropomodulin PF03250.14 KII64430.1 - 0.087 12.9 0.0 0.089 12.8 0.0 1.2 1 0 0 1 1 1 0 Tropomodulin Arabino_trans_N PF17689.1 KII64431.1 - 0.017 15.3 0.0 0.022 14.9 0.0 1.2 1 0 0 1 1 1 0 Arabinosyltransferase concanavalin like domain RT_RNaseH PF17917.1 KII64432.1 - 1.3e-37 128.2 0.5 1.3e-36 125.0 0.0 2.8 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII64432.1 - 4.1e-37 126.2 1.0 3.1e-36 123.4 0.1 3.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64432.1 - 1.3e-31 109.9 0.8 2.8e-31 108.8 0.1 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII64432.1 - 1.3e-21 77.0 0.0 3.6e-21 75.6 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64432.1 - 2.3e-19 69.2 0.3 6.4e-19 67.8 0.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII64432.1 - 0.00028 21.0 0.0 0.0008 19.6 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII64432.1 - 0.0019 17.9 0.1 0.0067 16.2 0.1 2.0 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 KII64432.1 - 0.0042 17.1 6.2 0.44 10.7 0.4 2.6 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII64432.1 - 0.0078 16.5 0.0 0.021 15.1 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KII64432.1 - 0.011 15.5 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_3 PF13917.6 KII64432.1 - 7 6.7 7.3 5.8 7.0 0.4 2.6 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII64432.1 - 7.6 6.4 8.1 28 4.5 2.4 2.7 1 1 1 2 2 2 0 Zinc knuckle MRP-S35 PF10246.9 KII64433.1 - 0.072 13.1 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein MRP-S35 PAS_2 PF08446.11 KII64435.1 - 0.0033 18.1 0.0 0.0073 17.0 0.0 1.5 1 0 0 1 1 1 1 PAS fold RVT_1 PF00078.27 KII64438.1 - 3.7e-11 43.0 0.2 7.2e-11 42.0 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 KII64438.1 - 0.00011 22.7 0.0 0.00027 21.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII64438.1 - 0.00016 22.2 0.0 0.00049 20.6 0.0 1.7 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII64438.1 - 0.034 14.4 0.0 0.16 12.3 0.0 2.2 2 1 0 2 2 2 0 Retroviral aspartyl protease G-alpha PF00503.20 KII64439.1 - 0.072 12.2 0.8 0.092 11.9 0.8 1.1 1 0 0 1 1 1 0 G-protein alpha subunit rve_3 PF13683.6 KII64440.1 - 0.085 12.6 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain Peptidase_S24 PF00717.23 KII64445.1 - 8.3e-08 32.1 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like DHR-2 PF06920.13 KII64446.1 - 1.5e-65 221.8 5.8 1.8e-65 221.6 5.8 1.0 1 0 0 1 1 1 1 Dock homology region 2 RNB PF00773.19 KII64447.1 - 2.2e-96 323.0 0.1 3e-96 322.6 0.1 1.2 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 KII64447.1 - 1.2e-16 60.4 0.0 3.7e-16 58.9 0.0 1.9 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 KII64447.1 - 0.0002 21.4 0.0 0.00075 19.6 0.0 2.0 1 0 0 1 1 1 1 Cold shock domain Rrp44_CSD1 PF17216.3 KII64447.1 - 0.00023 20.9 0.0 0.00048 19.9 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain RAB3GAP2_N PF14655.6 KII64448.1 - 0.023 14.0 6.0 0.063 12.5 0.7 2.5 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus BBS2_Mid PF14783.6 KII64448.1 - 0.085 12.9 0.2 0.97 9.5 0.1 2.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 KII64448.1 - 0.44 11.5 3.1 84 4.3 0.0 4.5 5 0 0 5 5 5 0 WD domain, G-beta repeat WD40 PF00400.32 KII64449.1 - 0.0054 17.5 4.9 1.8 9.6 0.2 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF1249 PF06853.12 KII64450.1 - 0.027 14.5 0.2 1.2 9.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1249) SWI2_SNF2 PF18766.1 KII64451.1 - 0.018 14.7 0.1 0.081 12.6 0.1 1.8 2 0 0 2 2 2 0 SWI2/SNF2 ATPase Homeodomain PF00046.29 KII64452.1 - 7.2e-09 35.4 1.1 1.1e-08 34.8 1.1 1.3 1 0 0 1 1 1 1 Homeodomain RT_RNaseH_2 PF17919.1 KII64453.1 - 7.9e-34 115.7 0.0 2.1e-33 114.3 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64453.1 - 2.5e-30 104.9 0.0 5e-30 103.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64453.1 - 6.1e-21 75.0 0.0 1.3e-20 73.9 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII64453.1 - 2.5e-16 59.5 0.3 1e-15 57.6 0.3 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII64453.1 - 1.7e-06 28.2 0.3 8.1e-05 22.8 0.3 2.6 1 1 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII64453.1 - 8.9e-05 22.6 0.3 0.00078 19.6 0.1 2.8 3 0 0 3 3 3 1 H2C2 zinc finger zf-CCHC PF00098.23 KII64453.1 - 0.0006 19.8 8.0 0.0012 18.9 1.0 2.7 2 0 0 2 2 2 1 Zinc knuckle rve_3 PF13683.6 KII64453.1 - 0.0018 18.0 0.0 0.0048 16.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 KII64453.1 - 0.029 15.0 0.0 0.066 13.9 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 KII64453.1 - 0.047 14.2 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.6 KII64453.1 - 0.092 12.5 8.8 0.28 11.0 2.3 2.6 2 0 0 2 2 2 0 Zinc knuckle Holin_BhlA PF10960.8 KII64453.1 - 1.3 9.1 4.3 0.94 9.5 1.2 2.3 2 0 0 2 2 2 0 BhlA holin family zf-CCHC_3 PF13917.6 KII64453.1 - 8.5 6.4 9.0 6.3 6.8 0.4 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 KII64454.1 - 4.3e-06 26.6 15.7 5.3e-06 26.3 1.6 3.1 2 1 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 KII64454.1 - 0.042 13.6 1.1 0.042 13.6 1.1 1.7 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 KII64455.1 - 8.7e-19 67.9 0.0 1.1e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII64455.1 - 1.4e-05 24.7 0.0 2.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HMG_box_5 PF14887.6 KII64456.1 - 0.11 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 HMG (high mobility group) box 5 Gemini_AL1_M PF08283.11 KII64457.1 - 0.12 12.5 0.1 4 7.6 0.2 2.1 1 1 0 2 2 2 0 Geminivirus rep protein central domain Orf78 PF06024.12 KII64458.1 - 0.00062 20.0 0.1 0.00097 19.4 0.1 1.4 1 0 0 1 1 1 1 Orf78 (ac78) TMEM154 PF15102.6 KII64458.1 - 0.0032 17.4 2.2 0.0047 16.8 2.2 1.2 1 0 0 1 1 1 1 TMEM154 protein family Pes-10 PF07149.11 KII64458.1 - 0.0033 16.6 6.9 0.0033 16.5 6.9 1.1 1 0 0 1 1 1 1 Pes-10 DUF4366 PF14283.6 KII64458.1 - 0.0037 17.3 1.2 0.0049 16.9 1.2 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4366) DUF5383 PF17355.2 KII64458.1 - 0.0056 17.1 4.4 0.0098 16.3 4.2 1.5 1 1 1 2 2 2 1 Family of unknown function (DUF5383) LRRC37AB_C PF14914.6 KII64458.1 - 0.014 15.3 0.3 0.023 14.6 0.3 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Podoplanin PF05808.11 KII64458.1 - 0.049 13.7 0.4 0.06 13.4 0.4 1.1 1 0 0 1 1 1 0 Podoplanin DUF2937 PF11157.8 KII64458.1 - 0.15 11.8 1.1 0.23 11.2 1.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2937) MscS_TM PF12794.7 KII64458.1 - 0.17 10.7 0.2 0.22 10.4 0.2 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF4558 PF15104.6 KII64458.1 - 0.67 10.0 4.3 0.74 9.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) Homeodomain PF00046.29 KII64461.1 - 1.7e-11 43.8 5.7 2.9e-11 43.0 5.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 KII64462.1 - 2.6e-11 43.2 1.2 5.9e-11 42.0 1.2 1.6 1 0 0 1 1 1 1 Homeodomain Terminase_5 PF06056.12 KII64462.1 - 0.075 12.9 0.6 0.15 12.0 0.6 1.4 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) MULE PF10551.9 KII64465.1 - 1.6e-12 47.7 1.5 2.6e-12 47.0 1.5 1.4 1 0 0 1 1 1 1 MULE transposase domain Nore1-SARAH PF16517.5 KII64466.1 - 0.48 10.4 2.9 1.1 9.3 1.2 2.3 1 1 1 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain MULE PF10551.9 KII64467.1 - 4.6e-12 46.2 1.6 3.6e-11 43.3 0.4 2.6 2 1 1 3 3 3 1 MULE transposase domain RT_RNaseH_2 PF17919.1 KII64468.1 - 4.4e-05 23.4 0.0 7.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64468.1 - 0.024 14.9 0.0 0.048 13.9 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase PurA PF04845.13 KII64469.1 - 0.067 12.5 0.0 0.14 11.5 0.0 1.4 2 0 0 2 2 2 0 PurA ssDNA and RNA-binding protein Pik1 PF11522.8 KII64469.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Yeast phosphatidylinositol-4-OH kinase Pik1 Sortilin-Vps10 PF15902.5 KII64470.1 - 4.1e-07 29.2 0.2 9e-06 24.7 0.0 2.5 3 0 0 3 3 3 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII64470.1 - 1.1e-06 28.8 7.9 1.1e-06 28.8 7.9 3.6 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A DUF5074 PF16819.5 KII64471.1 - 0.083 12.9 0.0 5.3 7.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5074) RRM_1 PF00076.22 KII64473.1 - 8.1e-24 83.2 0.3 2e-11 43.5 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII64473.1 - 1e-05 25.6 0.2 0.00076 19.5 0.0 3.3 2 2 0 2 2 2 1 RNA recognition motif PHM7_cyt PF14703.6 KII64473.1 - 0.0013 19.1 0.1 1.8 8.7 0.0 3.7 2 2 2 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter mRNA_decap_C PF16741.5 KII64473.1 - 0.39 10.0 2.2 0.88 8.9 0.9 2.2 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus Swi5 PF07061.11 KII64474.1 - 1.6e-07 31.3 0.7 8.9e-06 25.7 0.3 2.5 2 1 0 2 2 2 2 Swi5 MMR_HSR1_C PF08438.10 KII64474.1 - 0.099 13.2 0.1 0.61 10.7 0.0 2.1 2 1 0 2 2 2 0 GTPase of unknown function C-terminal SNRNP27 PF08648.12 KII64475.1 - 0.00079 19.5 1.3 0.00079 19.5 1.3 2.8 3 1 0 3 3 3 1 U4/U6.U5 small nuclear ribonucleoproteins NPR3 PF03666.13 KII64475.1 - 9.9 4.8 9.5 13 4.4 9.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1759 PF03564.15 KII64476.1 - 1.2e-13 51.2 6.4 9e-13 48.4 3.0 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1759) eIF3g PF12353.8 KII64476.1 - 0.11 12.8 0.4 0.11 12.8 0.4 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.23 KII64476.1 - 0.59 10.3 15.0 1.4 9.1 4.8 3.5 3 0 0 3 3 3 0 Zinc knuckle DUF1758 PF05585.12 KII64477.1 - 3.9e-10 39.7 1.7 4.7e-10 39.5 1.7 1.1 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 KII64477.1 - 0.0049 17.5 0.0 0.014 16.0 0.0 1.8 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 KII64477.1 - 0.023 15.2 0.0 0.041 14.4 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Sigma70_r4_2 PF08281.12 KII64477.1 - 0.2 11.3 0.1 0.52 10.0 0.1 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 Peptidase_A17 PF05380.13 KII64478.1 - 3.1e-43 147.6 0.0 1.2e-42 145.7 0.0 2.0 2 0 0 2 2 2 1 Pao retrotransposon peptidase RNase_H PF00075.24 KII64478.1 - 0.0051 17.0 0.0 0.014 15.6 0.0 1.8 1 0 0 1 1 1 1 RNase H IL6 PF00489.17 KII64478.1 - 0.035 13.7 0.1 0.071 12.7 0.1 1.4 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family DUF621 PF04789.15 KII64480.1 - 0.01 15.0 0.6 0.01 15.0 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF621) RNase_PH PF01138.21 KII64481.1 - 4.6e-17 62.7 0.2 2e-09 38.0 0.0 2.6 2 1 1 3 3 3 2 3' exoribonuclease family, domain 1 Thymosin PF01290.20 KII64482.1 - 1.4e-39 133.5 40.8 2e-07 30.6 1.2 7.3 6 1 1 7 7 7 7 Thymosin beta-4 family QueF PF14489.6 KII64482.1 - 0.02 15.1 0.1 2.9 8.1 0.0 2.7 2 0 0 2 2 2 0 QueF-like protein RNA_pol_Rpb1_4 PF05000.17 KII64482.1 - 0.054 13.4 0.1 0.21 11.5 0.0 2.1 2 1 0 2 2 2 0 RNA polymerase Rpb1, domain 4 WH2 PF02205.20 KII64482.1 - 2.7 8.0 15.9 1.4 8.8 0.2 4.9 5 0 0 5 5 5 0 WH2 motif Ank_2 PF12796.7 KII64485.1 - 4.6e-80 264.3 25.8 5.7e-13 49.3 0.5 8.5 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII64485.1 - 5.2e-71 234.2 21.2 3.3e-12 46.7 0.0 11.9 7 2 3 11 11 11 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 KII64485.1 - 1.1e-62 207.3 24.8 3.9e-11 43.0 0.0 14.2 4 2 10 14 14 14 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII64485.1 - 6.2e-58 185.9 31.1 0.00023 21.4 0.0 17.3 18 0 0 18 18 18 13 Ankyrin repeat Ank PF00023.30 KII64485.1 - 1.4e-53 177.1 29.1 1.7e-06 28.2 0.0 16.0 16 0 0 16 16 16 12 Ankyrin repeat DDE_3 PF13358.6 KII64486.1 - 0.023 14.4 0.1 0.046 13.5 0.1 1.5 2 0 0 2 2 2 0 DDE superfamily endonuclease 2OG-FeII_Oxy_3 PF13640.6 KII64487.1 - 7.6e-13 49.2 0.0 1.3e-12 48.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KII64487.1 - 0.00012 22.5 0.0 0.00019 21.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily P4Ha_N PF08336.11 KII64488.1 - 2.7e-14 53.4 0.0 4.6e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region APG6 PF04111.12 KII64489.1 - 7e-26 91.3 0.2 1.4e-25 90.3 0.2 1.5 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 KII64489.1 - 2.6e-05 24.7 0.0 6.8e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 Apg6 coiled-coil region IL12 PF03039.14 KII64489.1 - 0.023 14.0 1.3 0.047 13.0 1.3 1.4 1 0 0 1 1 1 0 Interleukin-12 alpha subunit PGBA_C PF15437.6 KII64490.1 - 0.03 14.7 3.1 0.03 14.7 3.1 2.4 1 1 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal LMBR1 PF04791.16 KII64490.1 - 0.2 10.6 4.0 0.21 10.5 4.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein EMP24_GP25L PF01105.24 KII64492.1 - 8e-14 52.0 0.1 9.5e-14 51.7 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3827 PF12877.7 KII64493.1 - 1.3 7.3 10.4 1.7 6.9 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) BTP PF05232.12 KII64497.1 - 4e-27 94.1 12.3 3e-19 68.9 7.0 2.0 2 0 0 2 2 2 2 Chlorhexidine efflux transporter CLP_protease PF00574.23 KII64498.1 - 1.6e-15 57.5 0.0 2.1e-15 57.1 0.0 1.0 1 0 0 1 1 1 1 Clp protease Glyco_hydro_4C PF11975.8 KII64499.1 - 3.3e-65 220.1 0.4 3.9e-65 219.8 0.4 1.1 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain Glyco_hydro_4 PF02056.16 KII64499.1 - 0.0003 20.4 0.5 0.00069 19.2 0.6 1.6 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase Glyco_hydro_4 PF02056.16 KII64500.1 - 8.3e-37 126.5 0.1 9.3e-37 126.4 0.1 1.0 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase DDE_3 PF13358.6 KII64501.1 - 5.3e-08 32.7 0.0 7.4e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3199 PF11436.8 KII64502.1 - 0.033 14.2 0.5 1.5 8.9 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3199) Adaptin_N PF01602.20 KII64503.1 - 0.0058 15.2 0.4 0.041 12.5 0.0 2.2 2 0 0 2 2 2 1 Adaptin N terminal region DDE_Tnp_IS1595 PF12762.7 KII64511.1 - 4.5e-10 39.7 0.0 5.5e-10 39.4 0.0 1.4 1 1 0 1 1 1 1 ISXO2-like transposase domain ApoB100_C PF12491.8 KII64511.1 - 0.044 13.8 0.8 0.74 9.8 0.1 2.8 3 0 0 3 3 3 0 Apolipoprotein B100 C terminal KH_8 PF17903.1 KII64512.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Krr1 KH1 domain rve PF00665.26 KII64513.1 - 1.5e-14 54.2 0.1 2.4e-14 53.6 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64513.1 - 7.3e-10 38.8 0.7 1.7e-09 37.6 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII64513.1 - 0.07 12.9 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH_2 PF17919.1 KII64514.1 - 1.8e-36 124.2 0.1 3.6e-36 123.2 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64514.1 - 3.8e-33 113.9 0.0 7.8e-33 112.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64514.1 - 1.1e-19 70.9 0.0 2.5e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII64514.1 - 5.2e-07 30.1 0.0 1.1e-06 29.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII64514.1 - 1.1e-05 26.0 0.0 2.9e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII64514.1 - 0.0036 17.6 0.1 0.01 16.1 0.1 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII64514.1 - 0.031 14.0 0.0 0.081 12.7 0.0 1.6 2 0 0 2 2 2 0 Aspartyl protease GlutR_dimer PF00745.20 KII64514.1 - 0.093 13.2 0.1 0.51 10.8 0.0 2.2 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF4573 PF15140.6 KII64518.1 - 3.2e-06 27.1 5.1 2.5e-05 24.2 5.1 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4573) Nucleoside_tran PF01733.18 KII64519.1 - 0.28 10.5 1.1 0.29 10.5 1.1 1.1 1 0 0 1 1 1 0 Nucleoside transporter NuA4 PF09340.10 KII64524.1 - 0.021 14.7 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 GDI PF00996.18 KII64524.1 - 0.026 13.1 0.0 0.028 13.0 0.0 1.0 1 0 0 1 1 1 0 GDP dissociation inhibitor DUF2451 PF10474.9 KII64525.1 - 0.079 12.7 0.0 0.099 12.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) DUF4472 PF14739.6 KII64527.1 - 0.00055 20.6 0.0 5.5 7.8 0.0 3.3 1 1 1 3 3 3 3 Domain of unknown function (DUF4472) DUF454 PF04304.13 KII64527.1 - 0.093 12.8 21.7 18 5.4 2.6 5.1 1 1 1 2 2 2 0 Protein of unknown function (DUF454) Mannosidase_ig PF17786.1 KII64527.1 - 0.77 10.4 29.7 47 4.7 1.0 6.8 1 1 5 6 6 6 0 Mannosidase Ig/CBM-like domain RNA_pol_Rpb1_1 PF04997.12 KII64531.1 - 2.6e-100 335.8 0.0 4.7e-100 334.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 KII64531.1 - 1e-99 333.4 0.1 1.5e-99 332.8 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KII64531.1 - 7.1e-74 247.5 0.1 1.4e-73 246.6 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 KII64531.1 - 7.6e-60 202.0 0.5 1.5e-59 201.1 0.5 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 KII64531.1 - 2.1e-48 164.3 0.4 5.2e-47 159.7 0.0 2.9 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 KII64531.1 - 7.9e-45 152.2 5.1 1.9e-44 150.9 5.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 KII64531.1 - 9.8e-36 122.0 0.1 2.1e-35 120.9 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 XET_C PF06955.12 KII64531.1 - 0.013 15.3 0.1 0.03 14.1 0.1 1.6 1 0 0 1 1 1 0 Xyloglucan endo-transglycosylase (XET) C-terminus Aconitase PF00330.20 KII64532.1 - 7.3e-16 58.2 0.4 9.4e-16 57.9 0.4 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Na_sulph_symp PF00939.19 KII64533.1 - 8e-48 163.7 4.7 8.7e-48 163.5 4.7 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KII64533.1 - 2.2e-07 30.4 2.1 2.7e-07 30.1 2.1 1.3 1 0 0 1 1 1 1 Citrate transporter HTH_15 PF12324.8 KII64535.1 - 0.013 15.4 2.3 1.1 9.3 0.3 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase LysR_substrate PF03466.20 KII64536.1 - 1.2e-20 73.7 0.1 1.5e-20 73.5 0.1 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 KII64536.1 - 4.7e-11 42.5 0.8 9.1e-11 41.6 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family Sortilin-Vps10 PF15902.5 KII64539.1 - 3.7e-06 26.0 3.8 4e-05 22.6 0.0 2.9 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, DUF3973 PF13119.6 KII64539.1 - 0.35 11.0 1.9 6.1 7.0 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3973) Insulin_TMD PF17870.1 KII64541.1 - 0.069 13.2 1.3 0.15 12.2 1.3 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment UL45 PF05473.12 KII64541.1 - 1 8.9 3.9 1.1 8.9 3.9 1.3 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Syndecan PF01034.20 KII64541.1 - 1.1 9.2 4.2 2.6 8.0 4.2 1.5 1 0 0 1 1 1 0 Syndecan domain Claudin_2 PF13903.6 KII64542.1 - 0.0036 17.1 8.8 0.0036 17.1 8.8 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF3754 PF12576.8 KII64542.1 - 5.9 6.8 6.5 1.5 8.8 2.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3754) Metallophos_C PF14008.6 KII64543.1 - 0.018 15.9 0.2 0.16 12.8 0.1 2.3 2 0 0 2 2 2 0 Iron/zinc purple acid phosphatase-like protein C POB3_N PF17292.2 KII64543.1 - 0.048 14.1 0.2 0.15 12.5 0.1 1.9 2 0 0 2 2 2 0 POB3-like N-terminal PH domain HTH_Tnp_Tc3_2 PF01498.18 KII64544.1 - 0.0017 18.5 0.5 0.0035 17.5 0.5 1.6 1 0 0 1 1 1 1 Transposase GerE PF00196.19 KII64544.1 - 0.0067 15.9 0.3 0.014 14.9 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_38 PF13936.6 KII64544.1 - 0.016 14.9 2.9 0.034 13.9 0.2 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Type2_restr_D3 PF16902.5 KII64544.1 - 0.074 13.0 1.2 0.25 11.3 0.2 2.1 1 1 1 2 2 2 0 Type-2 restriction enzyme D3 domain HTH_23 PF13384.6 KII64544.1 - 0.093 12.6 0.3 1.3 8.9 0.1 2.3 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 KII64545.1 - 4.8e-08 32.9 0.0 5.6e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Shisa PF13908.6 KII64546.1 - 0.031 14.5 0.1 0.054 13.7 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF5077 PF16871.5 KII64546.1 - 0.037 13.9 0.2 0.087 12.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5077) Yop-YscD_ppl PF16693.5 KII64546.1 - 0.12 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Inner membrane component of T3SS, periplasmic domain DUF872 PF05915.12 KII64546.1 - 0.43 10.7 2.0 0.48 10.6 0.3 1.9 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF2510 PF10708.9 KII64547.1 - 0.0085 15.8 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2510) DASH_Dad3 PF08656.10 KII64547.1 - 1.3 9.2 6.4 12 6.1 0.0 3.6 2 1 0 2 2 2 0 DASH complex subunit Dad3 Ninjurin PF04923.12 KII64548.1 - 0.03 14.2 0.1 0.043 13.7 0.1 1.3 1 0 0 1 1 1 0 Ninjurin zf-CCHC PF00098.23 KII64550.1 - 6.6e-05 22.8 0.9 0.00012 22.0 0.9 1.3 1 0 0 1 1 1 1 Zinc knuckle Cnn_1N PF07989.11 KII64550.1 - 0.026 14.7 0.7 0.38 10.9 0.1 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 zf-CCHC_2 PF13696.6 KII64553.1 - 0.093 12.6 0.5 0.17 11.7 0.5 1.4 1 0 0 1 1 1 0 Zinc knuckle Peptidase_M44 PF03410.13 KII64553.1 - 0.17 10.4 0.1 0.21 10.1 0.1 1.1 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox ChpA-C PF03777.13 KII64553.1 - 0.2 11.6 0.3 0.37 10.7 0.3 1.3 1 0 0 1 1 1 0 ChpA-C zf-CCHC PF00098.23 KII64553.1 - 0.3 11.2 0.9 0.39 10.9 0.1 1.6 2 0 0 2 2 2 0 Zinc knuckle RNA_pol_Rpb5_N PF03871.14 KII64554.1 - 1.1 9.8 6.3 0.26 11.9 1.4 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb5, N-terminal domain Pullulanase_Ins PF18494.1 KII64554.1 - 3.3 8.2 7.3 0.84 10.1 0.3 3.2 3 1 1 4 4 4 0 Pullulanase Ins domain DASH_Dad4 PF08650.10 KII64554.1 - 4 7.5 15.3 0.41 10.7 4.5 3.3 3 0 0 3 3 3 0 DASH complex subunit Dad4 DDE_3 PF13358.6 KII64555.1 - 1.6e-07 31.2 0.0 6.8e-07 29.1 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease PLDc_N PF13396.6 KII64559.1 - 0.032 14.1 0.9 0.059 13.3 0.9 1.4 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal Pox_EPC_I2-L1 PF12575.8 KII64559.1 - 0.1 12.8 1.1 0.37 11.1 0.6 2.0 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 ADAM_spacer1 PF05986.14 KII64559.1 - 0.11 12.5 0.2 0.28 11.2 0.1 1.6 1 1 0 1 1 1 0 ADAM-TS Spacer 1 PLDc_N PF13396.6 KII64561.1 - 0.007 16.3 0.8 0.015 15.2 0.8 1.5 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal AhpC-TSA PF00578.21 KII64564.1 - 0.014 15.3 1.6 0.18 11.8 0.0 2.3 1 1 1 2 2 2 0 AhpC/TSA family Integrase_H2C2 PF17921.1 KII64567.1 - 8.9e-13 48.1 0.1 1.2e-12 47.7 0.1 1.2 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII64568.1 - 2.9e-16 59.7 0.0 4.2e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Branch_AA_trans PF05525.13 KII64568.1 - 0.081 11.8 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport protein COG6 PF06419.11 KII64569.1 - 0.089 11.0 0.0 0.12 10.6 0.0 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 CarboxypepD_reg PF13620.6 KII64571.1 - 0.14 12.5 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain SNAP PF14938.6 KII64572.1 - 9.2e-17 61.4 0.3 1.2e-16 61.0 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 KII64572.1 - 0.022 14.8 7.5 1.4 9.2 0.1 4.5 3 1 0 4 4 4 0 Tetratricopeptide repeat Foie-gras_1 PF11817.8 KII64572.1 - 0.041 13.5 0.1 0.1 12.2 0.1 1.5 2 0 0 2 2 2 0 Foie gras liver health family 1 TPR_12 PF13424.6 KII64572.1 - 0.081 13.2 1.0 3.6 8.0 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KII64572.1 - 1.9 9.3 4.6 4.9 8.0 0.1 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Cullin PF00888.22 KII64575.1 - 0.019 13.6 0.1 0.019 13.6 0.1 1.1 1 0 0 1 1 1 0 Cullin family DUF2716 PF10898.8 KII64576.1 - 0.074 13.4 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2716) Mito_carr PF00153.27 KII64578.1 - 7.6e-46 154.0 8.9 2e-17 62.9 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein FtsJ PF01728.19 KII64580.1 - 1e-51 175.6 0.1 1.1e-51 175.4 0.1 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 KII64580.1 - 0.023 14.3 0.0 0.043 13.5 0.0 1.6 1 1 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 KII64580.1 - 0.08 13.7 0.0 0.22 12.3 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 KII64580.1 - 0.12 11.6 0.1 0.31 10.3 0.1 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF570 PF04489.13 KII64583.1 - 0.039 12.6 0.1 0.048 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF570) VAR1 PF05316.12 KII64583.1 - 0.29 10.1 9.4 0.4 9.7 8.7 1.5 1 1 0 1 1 1 0 Mitochondrial ribosomal protein (VAR1) HPIP PF15226.6 KII64584.1 - 0.18 12.2 0.6 0.4 11.1 0.6 1.5 1 0 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family DDE_Tnp_IS1595 PF12762.7 KII64585.1 - 1.8e-10 41.1 0.0 2.9e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DLIC PF05783.11 KII64586.1 - 2.1e-21 76.3 0.0 2.3e-10 39.9 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) MMR_HSR1 PF01926.23 KII64586.1 - 0.0017 18.4 0.0 0.0033 17.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 KII64586.1 - 0.0097 15.3 0.0 0.027 13.8 0.0 1.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_22 PF13401.6 KII64586.1 - 0.012 15.9 0.0 0.036 14.3 0.0 1.9 2 1 0 2 2 2 0 AAA domain SRPRB PF09439.10 KII64586.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KII64586.1 - 0.014 14.5 0.3 0.037 13.2 0.0 1.8 2 0 0 2 2 2 0 G-protein alpha subunit GTP_EFTU PF00009.27 KII64586.1 - 0.022 14.3 0.0 3.1 7.3 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Arf PF00025.21 KII64586.1 - 0.037 13.5 0.0 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family Roc PF08477.13 KII64586.1 - 0.039 14.2 0.0 0.075 13.2 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 KII64586.1 - 0.042 13.4 1.0 0.058 12.9 0.0 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 KII64586.1 - 0.052 13.3 0.0 0.28 10.9 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 KII64586.1 - 0.052 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_16 PF13191.6 KII64586.1 - 0.078 13.3 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 KII64586.1 - 0.11 11.7 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin MCM PF00493.23 KII64586.1 - 0.15 11.2 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_18 PF13238.6 KII64586.1 - 0.16 12.5 0.0 0.57 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain GNT-I PF03071.15 KII64590.1 - 9.5e-06 24.6 1.4 2.1e-05 23.5 1.0 2.0 1 1 1 2 2 2 1 GNT-I family MGAT2 PF05060.14 KII64590.1 - 0.013 14.6 0.2 0.022 13.8 0.1 1.3 1 1 0 1 1 1 0 N-acetylglucosaminyltransferase II (MGAT2) HMG_CoA_synt_N PF01154.17 KII64592.1 - 4.7e-60 202.4 0.2 6.9e-60 201.9 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 KII64592.1 - 3.1e-08 33.6 1.3 5.1e-08 32.9 1.3 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal Oxidored_molyb PF00174.19 KII64593.1 - 2.6e-47 160.6 0.0 6.3e-47 159.4 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Cyt-b5 PF00173.28 KII64593.1 - 7.2e-18 64.5 0.0 1.3e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain gag-asp_proteas PF13975.6 KII64594.1 - 0.00097 19.7 0.0 0.0023 18.5 0.0 1.6 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII64594.1 - 0.0064 16.8 0.0 0.012 15.9 0.0 1.5 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII64594.1 - 0.12 12.2 0.2 0.33 10.7 0.2 1.7 1 1 0 1 1 1 0 Aspartyl protease Asp_protease_2 PF13650.6 KII64594.1 - 0.18 12.5 0.0 0.3 11.8 0.0 1.5 1 1 0 1 1 1 0 Aspartyl protease RT_RNaseH_2 PF17919.1 KII64595.1 - 0.12 12.4 0.1 9.6 6.3 0.0 2.1 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase Radical_SAM_C PF16199.5 KII64596.1 - 6.4e-23 80.6 0.2 1.2e-22 79.8 0.2 1.4 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KII64596.1 - 5.2e-18 66.0 0.0 7e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Radical SAM superfamily La PF05383.17 KII64597.1 - 3.1e-08 33.5 0.1 4.9e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 La domain Integrin_beta PF00362.18 KII64598.1 - 1.4e-08 34.7 0.3 8.6e-05 22.3 0.0 2.1 1 1 1 2 2 2 2 Integrin beta chain VWA domain VWA_2 PF13519.6 KII64598.1 - 0.0012 19.4 0.0 0.0038 17.9 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain Serpin PF00079.20 KII64599.1 - 1.9e-05 24.1 0.2 2.1e-05 24.0 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sugar_tr PF00083.24 KII64600.1 - 0.0049 15.8 0.0 0.0054 15.7 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Sugar_tr PF00083.24 KII64601.1 - 1.1e-27 97.1 13.5 1.3e-27 96.8 13.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1656 PF07869.12 KII64601.1 - 0.015 15.3 1.0 0.015 15.3 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) Clc-like PF07062.12 KII64601.1 - 0.038 13.4 0.3 0.038 13.4 0.3 1.8 3 0 0 3 3 3 0 Clc-like Ribosom_S12_S23 PF00164.25 KII64602.1 - 9.2e-25 86.5 2.3 1.1e-24 86.3 2.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S12 PF17487.2 KII64602.1 - 0.022 15.4 0.0 0.056 14.2 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein S12 COMPASS-Shg1 PF05205.12 KII64603.1 - 0.00058 20.5 0.1 0.00077 20.1 0.1 1.2 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 HJURP_C PF12347.8 KII64603.1 - 0.14 12.3 0.4 0.14 12.3 0.4 1.7 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat DUF1104 PF06518.11 KII64603.1 - 0.31 11.4 3.4 2 8.9 3.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1104) AAA_23 PF13476.6 KII64604.1 - 0.013 16.0 0.2 0.022 15.3 0.2 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KII64604.1 - 0.015 15.8 0.1 0.027 15.0 0.1 1.4 1 0 0 1 1 1 0 ABC transporter Pox_A32 PF04665.12 KII64604.1 - 0.018 14.5 0.2 0.031 13.7 0.1 1.4 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_7 PF12775.7 KII64604.1 - 0.025 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 KII64604.1 - 0.026 14.3 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 KII64604.1 - 0.03 13.4 0.0 0.035 13.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 KII64604.1 - 0.089 12.2 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 KII64604.1 - 0.1 12.9 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 KII64604.1 - 0.11 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase Myosin_head PF00063.21 KII64604.1 - 0.12 10.5 0.0 0.16 10.2 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) HA2 PF04408.23 KII64605.1 - 1.4e-20 73.5 0.1 2.5e-20 72.8 0.1 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KII64605.1 - 1.6e-19 70.0 0.2 4e-19 68.7 0.2 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold STELLO PF03385.17 KII64605.1 - 0.0031 16.4 0.0 0.015 14.1 0.0 1.9 2 0 0 2 2 2 1 STELLO glycosyltransferases Band_7 PF01145.25 KII64607.1 - 4.6e-22 78.9 3.8 7e-22 78.3 3.8 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 KII64607.1 - 0.00057 20.0 1.4 0.0012 19.0 1.4 1.5 1 0 0 1 1 1 1 Mediator complex subunit 2 AAA_18 PF13238.6 KII64609.1 - 8e-05 23.2 3.0 0.0026 18.3 1.0 3.6 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KII64609.1 - 0.00014 22.3 0.0 0.00053 20.4 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain Mrr_cat PF04471.12 KII64609.1 - 0.00023 21.2 0.0 0.00056 19.9 0.0 1.7 1 0 0 1 1 1 1 Restriction endonuclease AAA_30 PF13604.6 KII64609.1 - 0.00033 20.4 0.0 0.00057 19.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KII64609.1 - 0.00071 19.1 0.1 0.0015 18.0 0.1 1.5 1 0 0 1 1 1 1 PhoH-like protein T2SSE PF00437.20 KII64609.1 - 0.0012 17.9 0.0 0.0023 17.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.12 KII64609.1 - 0.0014 18.5 0.1 0.0064 16.4 0.1 2.2 2 0 0 2 2 1 1 NACHT domain IstB_IS21 PF01695.17 KII64609.1 - 0.0015 18.2 0.3 0.028 14.1 0.0 2.8 4 0 0 4 4 3 1 IstB-like ATP binding protein Parvo_NS1 PF01057.17 KII64609.1 - 0.0027 16.8 0.0 0.0095 15.1 0.0 1.8 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 RsgA_GTPase PF03193.16 KII64609.1 - 0.0029 17.5 0.0 0.0068 16.3 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_28 PF13521.6 KII64609.1 - 0.0035 17.6 0.0 0.0088 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 KII64609.1 - 0.0035 17.3 0.3 0.03 14.3 0.1 2.2 2 0 0 2 2 2 1 NTPase NB-ARC PF00931.22 KII64609.1 - 0.0036 16.5 0.0 0.067 12.4 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_5 PF07728.14 KII64609.1 - 0.0037 17.3 0.0 0.018 15.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KII64609.1 - 0.0052 16.4 0.0 0.0091 15.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KII64609.1 - 0.011 16.1 0.1 0.031 14.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KII64609.1 - 0.03 14.7 0.0 0.1 13.0 0.0 2.0 1 0 0 1 1 1 0 RNA helicase PriC PF07445.12 KII64609.1 - 0.031 14.2 0.8 0.074 13.0 0.8 1.6 1 0 0 1 1 1 0 Primosomal replication protein priC AAA_24 PF13479.6 KII64609.1 - 0.034 13.9 0.1 0.097 12.4 0.1 1.8 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 KII64609.1 - 0.043 13.0 0.0 0.094 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 KII64609.1 - 0.045 13.8 4.9 0.047 13.7 0.1 3.1 2 1 1 3 3 2 0 AAA domain Ndr PF03096.14 KII64609.1 - 0.045 12.4 0.0 0.1 11.3 0.0 1.5 1 0 0 1 1 1 0 Ndr family Sigma54_activ_2 PF14532.6 KII64609.1 - 0.046 13.8 0.1 0.19 11.8 0.0 2.1 2 0 0 2 2 1 0 Sigma-54 interaction domain RuvB_N PF05496.12 KII64609.1 - 0.047 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 KII64609.1 - 0.053 13.9 0.0 0.22 12.0 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 KII64609.1 - 0.054 14.0 1.2 0.17 12.4 1.2 2.0 1 1 0 1 1 1 0 ABC transporter SRP54 PF00448.22 KII64609.1 - 0.063 12.9 0.0 0.48 10.0 0.0 2.4 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 KII64609.1 - 0.09 12.9 0.0 0.29 11.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KII64609.1 - 0.11 12.8 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KII64609.1 - 0.17 12.3 0.0 0.61 10.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain ARS2 PF04959.13 KII64612.1 - 6.6e-15 56.0 1.0 8.6e-15 55.6 0.0 1.7 2 0 0 2 2 2 1 Arsenite-resistance protein 2 DUF3546 PF12066.8 KII64612.1 - 4.8e-14 52.5 0.6 1.1e-13 51.4 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) DUF629 PF04780.12 KII64612.1 - 0.024 13.2 0.0 0.041 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-C2H2_aberr PF17017.5 KII64612.1 - 0.043 14.0 0.1 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 Aberrant zinc-finger zf-met PF12874.7 KII64612.1 - 0.22 11.9 1.0 0.62 10.5 1.0 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KII64612.1 - 0.34 11.2 2.1 0.97 9.8 2.1 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DDE_3 PF13358.6 KII64613.1 - 3.9e-26 91.6 0.0 2.1e-22 79.5 0.0 2.8 3 0 0 3 3 3 2 DDE superfamily endonuclease rve PF00665.26 KII64613.1 - 6.5e-23 81.2 0.0 7.1e-22 77.8 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64613.1 - 6.2e-16 58.3 0.2 1.3e-15 57.2 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain HTH_33 PF13592.6 KII64613.1 - 6.4e-08 32.1 0.0 2.1e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII64613.1 - 6.3e-05 23.1 0.0 0.00044 20.4 0.1 2.5 2 0 0 2 2 2 1 Transposase rve_3 PF13683.6 KII64613.1 - 0.00012 21.8 0.0 0.00044 20.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain HTH_32 PF13565.6 KII64613.1 - 0.00019 21.9 0.1 0.00057 20.4 0.1 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_11 PF08279.12 KII64613.1 - 0.00023 21.1 0.6 0.67 9.9 0.1 2.9 2 0 0 2 2 2 2 HTH domain PAX PF00292.18 KII64613.1 - 0.00024 21.0 0.2 0.00054 19.9 0.2 1.5 1 0 0 1 1 1 1 'Paired box' domain zf-H2C2 PF09337.10 KII64613.1 - 0.00054 20.1 0.1 0.002 18.3 0.0 2.1 2 0 0 2 2 1 1 H2C2 zinc finger HTH_23 PF13384.6 KII64613.1 - 0.0028 17.4 0.0 2 8.3 0.0 2.6 2 0 0 2 2 2 2 Homeodomain-like domain TrmB PF01978.19 KII64613.1 - 0.0048 16.7 0.0 0.14 12.0 0.0 2.8 3 0 0 3 3 3 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 KII64613.1 - 0.018 14.6 0.7 0.32 10.6 0.1 2.7 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding HTH_Tnp_1_2 PF13022.6 KII64613.1 - 0.023 14.9 0.3 0.059 13.5 0.3 1.6 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_Tnp_IS630 PF01710.16 KII64613.1 - 0.057 13.5 0.2 0.25 11.4 0.2 2.0 1 1 0 1 1 1 0 Transposase Sigma70_r4_2 PF08281.12 KII64613.1 - 0.088 12.5 0.0 0.27 10.9 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_DeoR PF08220.12 KII64613.1 - 0.11 12.2 0.4 0.49 10.2 0.0 2.2 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 KII64613.1 - 0.19 11.1 1.3 23 4.5 0.2 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 Snf7 PF03357.21 KII64614.1 - 6e-25 87.8 13.6 7.4e-25 87.5 13.6 1.1 1 0 0 1 1 1 1 Snf7 NYD-SP28 PF14772.6 KII64614.1 - 0.016 15.2 2.8 0.016 15.2 2.8 2.7 2 1 0 2 2 2 0 Sperm tail DDE_Tnp_IS240 PF13610.6 KII64614.1 - 0.077 13.2 1.2 0.13 12.4 0.6 1.7 1 1 1 2 2 2 0 DDE domain UvrD-helicase PF00580.21 KII64614.1 - 0.47 9.9 10.4 0.2 11.1 4.6 2.0 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain hGDE_central PF14702.6 KII64615.1 - 1.3e-25 90.5 0.1 1.8e-25 90.0 0.1 1.2 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme GDE_C PF06202.14 KII64617.1 - 7e-63 212.8 0.0 7.9e-63 212.7 0.0 1.0 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase EF-hand_1 PF00036.32 KII64618.1 - 4.5e-24 82.1 21.4 0.00026 20.3 0.0 6.4 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 KII64618.1 - 1.9e-23 82.7 18.1 8.9e-09 35.7 0.1 3.6 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KII64618.1 - 2.1e-22 77.1 18.0 0.0017 18.2 0.0 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.6 KII64618.1 - 6e-15 54.0 18.5 0.0071 15.8 0.7 6.4 6 0 0 6 6 6 5 EF hand SPARC_Ca_bdg PF10591.9 KII64618.1 - 1.2e-10 41.7 12.1 0.00026 21.3 0.5 3.6 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KII64618.1 - 1.2e-08 34.6 12.8 0.04 13.8 0.4 5.3 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_4 PF12763.7 KII64618.1 - 0.049 13.6 5.0 3.8 7.5 0.0 3.5 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Peptidase_M9_N PF08453.10 KII64618.1 - 0.067 12.9 0.1 0.15 11.8 0.0 1.5 2 0 0 2 2 2 0 Peptidase family M9 N-terminal Complex1_LYR_2 PF13233.6 KII64618.1 - 0.22 12.3 1.4 9.3 7.1 0.1 2.5 1 1 1 2 2 2 0 Complex1_LYR-like 2-oxogl_dehyd_N PF16078.5 KII64618.1 - 0.26 10.9 1.8 1.9 8.2 0.1 2.5 2 0 0 2 2 2 0 2-oxoglutarate dehydrogenase N-terminus Dockerin_1 PF00404.18 KII64618.1 - 0.85 9.9 10.3 1 9.6 1.8 3.6 3 2 1 4 4 4 0 Dockerin type I domain EF-hand_10 PF14788.6 KII64618.1 - 1.2 9.0 7.6 5.5 6.9 0.3 3.6 3 2 2 5 5 5 0 EF hand UCH PF00443.29 KII64621.1 - 9.6e-31 107.2 0.2 1.6e-30 106.5 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KII64621.1 - 4.4e-06 26.5 0.0 6.9e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TRAM_LAG1_CLN8 PF03798.16 KII64622.1 - 2.1e-18 66.8 9.1 2.1e-18 66.8 9.1 2.0 2 0 0 2 2 2 1 TLC domain Aldedh PF00171.22 KII64624.1 - 1.5e-10 40.2 0.0 1.7e-10 40.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rep_fac-A_3 PF08661.11 KII64625.1 - 0.00028 21.2 0.0 0.00033 21.0 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 DUF1409 PF07197.12 KII64627.1 - 0.013 15.4 0.1 3.2 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1409) DUF1366 PF07104.11 KII64628.1 - 0.0028 17.3 1.0 0.0034 17.0 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1366) DNA_ligase_A_N PF04675.14 KII64628.1 - 0.0038 17.6 0.2 0.0041 17.5 0.2 1.1 1 0 0 1 1 1 1 DNA ligase N terminus DASH_Dad2 PF08654.10 KII64628.1 - 0.034 14.6 1.0 0.049 14.0 1.0 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad2 DUF3557 PF12078.8 KII64628.1 - 0.038 14.0 0.1 0.041 13.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3557) NPV_P10 PF05531.12 KII64628.1 - 0.053 14.0 0.2 0.076 13.5 0.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein MbeB_N PF04837.12 KII64628.1 - 0.063 13.6 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 MbeB-like, N-term conserved region AAA PF00004.29 KII64629.1 - 1.2e-16 61.4 0.0 1.7e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII64629.1 - 2.3e-06 28.1 0.0 2.9e-06 27.8 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KII64629.1 - 2.9e-06 27.1 0.0 3.2e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KII64629.1 - 9.5e-05 22.4 0.0 0.00014 21.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KII64629.1 - 0.00012 21.4 0.0 0.00014 21.2 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 KII64629.1 - 0.00021 21.3 0.0 0.00023 21.1 0.0 1.1 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 KII64629.1 - 0.00031 21.3 0.0 0.00053 20.5 0.0 1.4 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 KII64629.1 - 0.00034 20.9 0.0 0.00042 20.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KII64629.1 - 0.00042 20.1 0.0 0.00059 19.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 KII64629.1 - 0.00089 19.4 0.0 0.0012 19.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KII64629.1 - 0.0018 18.6 0.0 0.0025 18.2 0.0 1.3 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 KII64629.1 - 0.0021 17.5 0.2 0.0058 16.0 0.1 1.6 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KII64629.1 - 0.0029 17.5 0.0 0.004 17.0 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KII64629.1 - 0.0031 17.0 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 KII64629.1 - 0.0053 16.5 0.0 0.0059 16.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KII64629.1 - 0.0096 15.2 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_11 PF13086.6 KII64629.1 - 0.013 15.3 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 KII64629.1 - 0.013 15.6 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate kinase AAA_28 PF13521.6 KII64629.1 - 0.014 15.7 0.0 0.019 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KII64629.1 - 0.017 14.8 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 KII64629.1 - 0.019 14.9 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ATPase PF06745.13 KII64629.1 - 0.021 14.2 0.0 0.023 14.0 0.0 1.3 1 1 0 1 1 1 0 KaiC DUF815 PF05673.13 KII64629.1 - 0.023 13.8 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 KII64629.1 - 0.024 14.1 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 KII64629.1 - 0.029 14.0 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KII64629.1 - 0.039 14.4 0.0 0.064 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 KII64629.1 - 0.039 13.7 0.0 0.055 13.2 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase DUF2075 PF09848.9 KII64629.1 - 0.052 12.8 0.0 0.057 12.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 KII64629.1 - 0.058 13.1 0.0 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KII64629.1 - 0.067 13.5 0.0 0.076 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 KII64629.1 - 0.087 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Thymidylate_kin PF02223.17 KII64629.1 - 0.12 12.1 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase ResIII PF04851.15 KII64629.1 - 0.12 12.3 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 KII64629.1 - 0.18 11.7 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PPV_E1_C PF00519.17 KII64629.1 - 0.19 10.5 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase AAA PF00004.29 KII64630.1 - 6.6e-16 58.9 0.1 9.9e-16 58.4 0.1 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KII64630.1 - 1.5e-13 50.3 0.2 2.5e-13 49.6 0.2 1.3 1 0 0 1 1 1 1 AAA+ lid domain TUDOR PF00567.24 KII64631.1 - 3.6e-13 49.6 1.7 2.6e-07 30.7 0.0 3.2 3 0 0 3 3 3 2 Tudor domain CS PF04969.16 KII64631.1 - 3.1e-06 28.1 0.4 1.5e-05 25.9 0.4 2.3 1 0 0 1 1 1 1 CS domain DEAD PF00270.29 KII64631.1 - 0.002 17.9 0.0 0.0045 16.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII64631.1 - 0.15 12.4 0.1 0.61 10.5 0.1 2.1 1 0 0 1 1 1 0 Helicase conserved C-terminal domain PDZ PF00595.24 KII64634.1 - 0.0016 18.7 0.0 0.0026 18.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII64635.1 - 2.9e-07 30.2 0.0 5.1e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KII64635.1 - 2.2e-05 24.7 0.0 0.00011 22.4 0.0 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KII64635.1 - 0.00022 21.5 0.0 0.00037 20.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain E1_DerP2_DerF2 PF02221.15 KII64637.1 - 0.0004 20.8 0.0 0.00046 20.6 0.0 1.1 1 0 0 1 1 1 1 ML domain DUF934 PF06073.12 KII64637.1 - 0.14 12.0 0.0 1.8 8.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF934) Zip PF02535.22 KII64638.1 - 2.6e-38 132.1 8.5 9.7e-38 130.2 8.5 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter PHO4 PF01384.20 KII64638.1 - 0.027 13.5 4.0 0.038 13.0 4.0 1.2 1 0 0 1 1 1 0 Phosphate transporter family DUF1129 PF06570.11 KII64638.1 - 0.28 10.7 2.3 0.53 9.7 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Peptidase_G2 PF11962.8 KII64639.1 - 0.11 11.9 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase_G2, IMC autoproteolytic cleavage domain Pkinase PF00069.25 KII64640.1 - 7e-76 255.1 0.0 1.2e-75 254.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII64640.1 - 9.6e-35 120.1 0.0 1.5e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CaMKII_AD PF08332.10 KII64640.1 - 4.8e-26 91.4 0.0 1.1e-25 90.3 0.0 1.6 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain SnoaL_3 PF13474.6 KII64640.1 - 0.00027 21.2 0.0 0.00078 19.7 0.0 1.8 1 1 0 1 1 1 1 SnoaL-like domain Kdo PF06293.14 KII64640.1 - 0.0035 16.7 0.1 0.0087 15.4 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KII64640.1 - 0.0048 15.7 0.0 0.0087 14.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF4440 PF14534.6 KII64640.1 - 0.0099 16.3 0.0 0.022 15.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Kinase-like PF14531.6 KII64640.1 - 0.01 15.2 0.4 0.027 13.8 0.1 1.9 2 1 0 2 2 2 0 Kinase-like DUF3804 PF12707.7 KII64640.1 - 0.017 14.8 0.0 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3804) 5_nucleotid PF05761.14 KII64640.1 - 0.065 12.1 0.2 0.12 11.2 0.2 1.4 1 0 0 1 1 1 0 5' nucleotidase family Fra10Ac1 PF09725.9 KII64642.1 - 8.8e-48 161.5 2.4 8.8e-48 161.5 2.4 1.9 2 0 0 2 2 2 1 Folate-sensitive fragile site protein Fra10Ac1 NdhM PF10664.9 KII64642.1 - 0.071 13.4 1.5 0.18 12.1 0.1 2.2 2 0 0 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M UCR_6-4kD PF08997.10 KII64642.1 - 0.12 12.3 1.1 0.2 11.6 0.1 1.9 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein DUF999 PF06198.11 KII64642.1 - 7.3 6.6 9.7 1.4 8.9 0.2 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF999) FCH PF00611.23 KII64644.1 - 3.4e-05 24.0 0.5 4.1e-05 23.8 0.5 1.3 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Gal-3-0_sulfotr PF06990.11 KII64645.1 - 1e-22 80.6 4.3 1.7e-21 76.6 4.3 1.9 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Ldl_recept_a PF00057.18 KII64646.1 - 2e-07 31.1 9.6 2e-07 31.1 9.6 4.0 4 0 0 4 4 4 1 Low-density lipoprotein receptor domain class A SNAP PF14938.6 KII64648.1 - 6.2e-15 55.4 0.3 1e-14 54.7 0.3 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 KII64648.1 - 0.0043 17.1 3.5 0.63 10.3 0.3 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KII64648.1 - 0.0066 16.2 2.5 0.37 10.7 0.3 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat SHP PF03579.13 KII64649.1 - 0.054 13.5 1.7 0.16 12.0 0.0 2.5 3 0 0 3 3 3 0 Small hydrophobic protein PAX PF00292.18 KII64650.1 - 0.0088 16.0 0.0 0.0095 15.9 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_11 PF08279.12 KII64650.1 - 0.023 14.7 0.1 0.28 11.2 0.0 2.1 2 0 0 2 2 2 0 HTH domain HTH_41 PF14502.6 KII64650.1 - 0.049 13.3 0.0 0.084 12.6 0.0 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_38 PF13936.6 KII64650.1 - 0.061 13.1 0.0 6.8 6.5 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Bcl-2 PF00452.19 KII64651.1 - 0.015 15.9 0.3 0.55 10.9 0.2 3.4 1 1 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family FBA PF04300.13 KII64651.1 - 0.048 13.3 0.1 0.088 12.5 0.1 1.3 1 0 0 1 1 1 0 F-box associated region zf-C2H2_8 PF15909.5 KII64651.1 - 0.42 10.9 1.6 0.49 10.7 0.1 1.8 2 0 0 2 2 2 0 C2H2-type zinc ribbon DDE_Tnp_IS1595 PF12762.7 KII64652.1 - 4e-17 62.6 0.0 6.7e-17 61.9 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain MULE PF10551.9 KII64653.1 - 0.0047 17.3 0.0 0.0085 16.5 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain Phage_integrase PF00589.22 KII64655.1 - 7e-23 81.3 0.8 4.4e-22 78.7 0.8 2.1 1 1 0 1 1 1 1 Phage integrase family Phage_int_SAM_4 PF13495.6 KII64655.1 - 0.0059 17.1 0.0 0.015 15.7 0.0 1.8 1 1 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 KII64655.1 - 0.014 15.7 0.0 0.053 13.8 0.0 2.0 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain DUF4317 PF14199.6 KII64655.1 - 0.085 12.0 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) HTH_3 PF01381.22 KII64656.1 - 1.5e-08 34.6 0.0 2.3e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 KII64656.1 - 0.00038 20.8 0.0 0.00053 20.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain MqsA_antitoxin PF15731.5 KII64656.1 - 0.017 15.3 0.0 0.024 14.7 0.0 1.2 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA MerR PF00376.23 KII64656.1 - 0.017 14.8 0.0 0.039 13.7 0.0 1.6 1 0 0 1 1 1 0 MerR family regulatory protein HTH_19 PF12844.7 KII64656.1 - 0.018 15.0 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain DUF835 PF05763.12 KII64656.1 - 0.024 14.4 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF835) MerR_1 PF13411.6 KII64656.1 - 0.094 12.8 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 MerR HTH family regulatory protein DUF4754 PF15946.5 KII64657.1 - 0.087 13.1 0.1 0.21 11.9 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4754) DUF5051 PF16473.5 KII64658.1 - 3.5e-45 154.0 0.0 3.9e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like RNase_T PF00929.24 KII64658.1 - 0.034 14.7 0.1 0.59 10.7 0.0 2.3 2 1 0 2 2 2 0 Exonuclease PAPS_reduct PF01507.19 KII64659.1 - 9.5e-52 175.5 0.0 1.2e-51 175.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Phage_lysozyme PF00959.19 KII64660.1 - 0.003 18.0 0.1 3.4 8.1 0.0 2.5 2 0 0 2 2 2 2 Phage lysozyme DUF2806 PF10987.8 KII64661.1 - 6.3e-05 23.0 1.1 8.3e-05 22.6 0.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2806) NUMOD1 PF07453.13 KII64661.1 - 0.096 13.0 0.4 0.22 11.8 0.4 1.6 1 0 0 1 1 1 0 NUMOD1 domain bZIP_2 PF07716.15 KII64663.1 - 0.096 12.8 12.8 0.16 12.0 12.8 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Pneumovirus_M2 PF06436.11 KII64664.1 - 0.085 12.3 0.3 0.13 11.7 0.3 1.4 1 1 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) RT_RNaseH_2 PF17919.1 KII64665.1 - 2.7e-31 107.5 0.0 6.2e-31 106.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64665.1 - 1.6e-28 99.1 0.0 3.6e-28 97.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64665.1 - 4.2e-28 98.4 0.0 7.1e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII64665.1 - 1.7e-22 79.8 0.1 7.5e-22 77.8 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64665.1 - 4.2e-15 55.6 0.9 1.6e-14 53.7 0.9 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII64665.1 - 0.00016 22.1 0.0 0.00038 21.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 KII64665.1 - 0.00048 19.9 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII64665.1 - 0.0082 16.4 0.0 0.026 14.9 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.10 KII64665.1 - 0.021 15.0 0.1 0.079 13.2 0.1 2.1 1 0 0 1 1 1 0 H2C2 zinc finger Asp_protease_2 PF13650.6 KII64665.1 - 0.03 15.0 0.0 0.079 13.6 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease AT_hook PF02178.19 KII64667.1 - 0.0012 18.4 2.6 0.004 16.8 2.6 2.0 1 0 0 1 1 1 1 AT hook motif MukE PF04288.13 KII64669.1 - 0.027 13.4 0.0 0.039 12.9 0.0 1.2 1 0 0 1 1 1 0 MukE-like family TPR_22 PF18833.1 KII64669.1 - 0.057 13.6 0.0 0.07 13.3 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat DDE_3 PF13358.6 KII64670.1 - 2.8e-17 62.8 0.1 3.6e-17 62.5 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII64670.1 - 0.0011 19.2 0.0 0.0023 18.1 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain Diphthamide_syn PF01866.17 KII64670.1 - 0.034 13.6 0.0 0.038 13.4 0.0 1.1 1 0 0 1 1 1 0 Putative diphthamide synthesis protein AT_hook PF02178.19 KII64671.1 - 0.065 13.1 3.1 0.16 11.9 3.1 1.7 1 0 0 1 1 1 0 AT hook motif EZH2_WD-Binding PF11616.8 KII64674.1 - 0.046 13.8 1.4 9.4 6.4 0.0 2.4 2 0 0 2 2 2 0 WD repeat binding protein EZH2 ACP_PD PF04336.12 KII64674.1 - 0.088 13.2 0.0 0.7 10.3 0.0 2.2 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase DNase-RNase PF02577.14 KII64675.1 - 0.019 14.6 0.0 0.5 10.0 0.0 2.2 2 0 0 2 2 2 0 Bifunctional nuclease YwcE PF17368.2 KII64675.1 - 0.33 11.6 2.9 0.62 10.8 2.9 1.4 1 0 0 1 1 1 0 Spore morphogenesis and germination YwcE TIM PF00121.18 KII64677.1 - 1.5e-08 34.3 0.0 1.9e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase Kri1_C PF12936.7 KII64678.1 - 7.3e-24 83.8 0.2 7.3e-24 83.8 0.2 2.7 4 0 0 4 4 4 1 KRI1-like family C-terminal NPR1_interact PF15699.5 KII64678.1 - 0.73 10.5 7.4 0.2 12.3 0.8 2.3 2 0 0 2 2 2 0 NPR1 interacting RT_RNaseH_2 PF17919.1 KII64680.1 - 0.001 19.1 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64681.1 - 4.1e-14 52.6 0.0 4.7e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.14 KII64681.1 - 0.082 12.5 0.0 0.23 11.0 0.0 1.7 1 1 1 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) CCDC32 PF14989.6 KII64683.1 - 0.0037 17.3 0.6 0.0071 16.4 0.6 1.4 1 0 0 1 1 1 1 Coiled-coil domain containing 32 RRF PF01765.19 KII64683.1 - 0.015 15.3 0.5 2.4 8.1 0.2 2.1 2 0 0 2 2 2 0 Ribosome recycling factor Molybdopterin PF00384.22 KII64683.1 - 0.18 10.7 0.0 0.2 10.6 0.0 1.0 1 0 0 1 1 1 0 Molybdopterin oxidoreductase DDE_3 PF13358.6 KII64684.1 - 6.4e-09 35.7 0.0 8.7e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease MFS_1 PF07690.16 KII64685.1 - 8.5e-11 41.4 23.7 4.1e-07 29.3 8.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KII64685.1 - 4.6e-06 25.4 12.2 0.00017 20.3 9.8 2.3 2 1 0 2 2 2 2 MFS/sugar transport protein HTH_23 PF13384.6 KII64686.1 - 0.00019 21.2 0.1 0.0035 17.1 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII64686.1 - 0.00097 19.3 0.7 0.0021 18.3 0.7 1.6 1 0 0 1 1 1 1 Transposase HTH_7 PF02796.15 KII64686.1 - 0.026 14.6 0.1 0.062 13.4 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Type2_restr_D3 PF16902.5 KII64686.1 - 0.034 14.1 0.3 0.034 14.1 0.3 2.3 2 1 0 2 2 2 0 Type-2 restriction enzyme D3 domain HTH_28 PF13518.6 KII64686.1 - 0.044 13.9 0.0 0.076 13.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Arg_repressor PF01316.21 KII64686.1 - 0.049 13.4 0.9 0.049 13.4 0.9 2.0 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain HTH_Tnp_1 PF01527.20 KII64686.1 - 0.08 13.3 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Transposase YflT PF11181.8 KII64686.1 - 0.12 12.9 1.3 0.18 12.3 0.6 1.6 2 0 0 2 2 2 0 Heat induced stress protein YflT HTH_23 PF13384.6 KII64687.1 - 1.3e-05 24.9 0.0 1.9e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.6 KII64687.1 - 0.00029 20.3 0.0 0.00053 19.5 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 KII64687.1 - 0.00082 19.2 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB CENP-B_N PF04218.13 KII64687.1 - 0.0023 17.5 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain MarR_2 PF12802.7 KII64687.1 - 0.0052 16.6 0.0 0.0078 16.1 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_29 PF13551.6 KII64687.1 - 0.021 14.8 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Fe_dep_repress PF01325.19 KII64687.1 - 0.021 15.0 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Sigma70_r4_2 PF08281.12 KII64687.1 - 0.042 13.5 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 Sigma70_r4 PF04545.16 KII64687.1 - 0.046 13.2 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_38 PF13936.6 KII64687.1 - 0.053 13.3 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain 4HB_MCP_1 PF12729.7 KII64687.1 - 0.087 12.4 0.2 2.9 7.4 0.1 2.0 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction HTH_1 PF00126.27 KII64687.1 - 0.096 12.7 0.2 0.35 10.9 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_28 PF13518.6 KII64687.1 - 0.16 12.1 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_50 PF18024.1 KII64687.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Ribosomal_L13e PF01294.18 KII64688.1 - 2.3e-68 229.6 2.1 3e-68 229.2 2.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Herpes_LP PF03363.13 KII64688.1 - 0.084 12.7 0.4 0.14 12.0 0.4 1.3 1 0 0 1 1 1 0 Herpesvirus leader protein DDE_1 PF03184.19 KII64689.1 - 0.00095 18.9 0.3 0.0029 17.3 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease SWC7 PF17330.2 KII64690.1 - 0.22 11.6 4.3 0.37 10.9 0.2 3.6 5 0 0 5 5 5 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 FRB_dom PF08771.11 KII64690.1 - 3.4 8.2 9.4 13 6.3 0.4 4.4 3 0 0 3 3 3 0 FKBP12-rapamycin binding domain WD40 PF00400.32 KII64692.1 - 1.3e-40 136.6 24.9 4.8e-06 27.2 0.1 9.7 8 1 1 9 9 9 7 WD domain, G-beta repeat Utp12 PF04003.12 KII64692.1 - 1.3e-15 57.6 0.4 3.4e-15 56.3 0.4 1.7 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 KII64692.1 - 2.1e-11 44.0 2.5 0.071 13.4 0.0 7.6 4 3 2 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Utp21 PF04192.12 KII64692.1 - 0.00025 20.6 0.2 0.0005 19.6 0.2 1.5 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain Nup160 PF11715.8 KII64692.1 - 0.00043 19.1 1.4 3.2 6.3 0.0 3.8 4 0 0 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 KII64692.1 - 0.00063 19.2 11.6 0.073 12.4 0.1 3.8 2 1 1 4 4 4 4 WD40-like domain Ribosomal_L11 PF00298.19 KII64693.1 - 4.7e-18 65.5 0.1 7.7e-18 64.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 KII64693.1 - 1.7e-15 56.6 0.2 3.7e-15 55.5 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain DDE_3 PF13358.6 KII64694.1 - 0.0054 16.5 0.0 0.0092 15.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Amino_oxidase PF01593.24 KII64694.1 - 0.053 12.8 0.0 0.065 12.5 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KII64694.1 - 0.056 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain RA PF00788.23 KII64695.1 - 2.3e-10 41.0 0.1 7e-10 39.4 0.1 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DIL PF01843.19 KII64695.1 - 3.1e-06 27.4 0.3 1.6e-05 25.1 0.3 2.3 1 0 0 1 1 1 1 DIL domain PCI PF01399.27 KII64695.1 - 0.19 12.2 2.2 0.46 11.0 0.6 2.5 2 0 0 2 2 2 0 PCI domain AF0941-like PF14591.6 KII64695.1 - 2.4 8.8 6.3 5.3 7.7 0.2 3.8 3 1 1 4 4 4 0 AF0941-like RA PF00788.23 KII64696.1 - 8e-06 26.4 0.0 1.1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Coilin_N PF15862.5 KII64698.1 - 0.00023 21.0 0.4 0.00044 20.1 0.0 1.7 2 1 0 2 2 2 1 Coilin N-terminus DUF1143 PF06608.11 KII64698.1 - 0.085 12.9 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) Chitin_bind_1 PF00187.19 KII64699.1 - 0.023 15.2 0.5 0.036 14.5 0.5 1.2 1 0 0 1 1 1 0 Chitin recognition protein Rhabdo_glycop PF00974.18 KII64700.1 - 0.0015 17.1 0.0 0.0022 16.6 0.0 1.2 1 0 0 1 1 1 1 Rhabdovirus spike glycoprotein TMEM154 PF15102.6 KII64700.1 - 0.0052 16.7 1.7 0.0095 15.8 1.7 1.5 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 KII64700.1 - 0.0058 17.5 0.0 0.011 16.6 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 KII64700.1 - 0.028 14.6 0.4 0.041 14.1 0.4 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator OAD_gamma PF04277.13 KII64700.1 - 0.029 15.0 0.2 0.051 14.2 0.2 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Orthoreo_P10 PF07204.11 KII64700.1 - 0.029 14.3 0.5 0.056 13.4 0.5 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Cadherin_C_2 PF16492.5 KII64700.1 - 0.034 14.9 0.1 0.11 13.2 0.0 1.9 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Protocadherin PF08374.11 KII64700.1 - 0.036 14.1 0.1 0.053 13.5 0.1 1.3 1 0 0 1 1 1 0 Protocadherin ODV-E18 PF10717.9 KII64700.1 - 1.2 9.0 7.7 1.7 8.5 5.0 2.4 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 PRIMA1 PF16101.5 KII64700.1 - 1.2 9.2 3.2 2.2 8.3 3.2 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Synaptobrevin PF00957.21 KII64700.1 - 1.8 8.4 6.5 3.8 7.4 6.5 1.6 1 0 0 1 1 1 0 Synaptobrevin HEAT PF02985.22 KII64702.1 - 1.5e-05 24.8 0.1 0.013 15.7 0.0 3.4 3 0 0 3 3 3 1 HEAT repeat Pkinase PF00069.25 KII64702.1 - 0.00042 19.8 2.8 0.00088 18.7 0.3 2.5 3 0 0 3 3 3 1 Protein kinase domain CLASP_N PF12348.8 KII64702.1 - 0.00074 19.1 0.5 0.68 9.4 0.0 3.1 2 1 1 3 3 3 2 CLASP N terminal Pkinase_Tyr PF07714.17 KII64702.1 - 0.0012 18.2 0.1 0.0022 17.3 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Cohesin_HEAT PF12765.7 KII64702.1 - 0.0022 18.2 0.1 0.0058 16.9 0.1 1.8 1 0 0 1 1 1 1 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 KII64702.1 - 0.0043 17.1 1.7 0.031 14.3 0.0 3.1 3 2 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KII64702.1 - 0.03 14.7 0.0 0.33 11.4 0.0 2.4 2 0 0 2 2 2 0 HEAT repeats HEAT_EZ PF13513.6 KII64702.1 - 0.032 14.8 0.0 0.094 13.2 0.0 1.9 2 0 0 2 2 2 0 HEAT-like repeat FYVE PF01363.21 KII64704.1 - 0.00084 19.4 0.1 0.0016 18.5 0.1 1.4 1 0 0 1 1 1 1 FYVE zinc finger FPP PF05911.11 KII64704.1 - 0.0097 14.1 17.5 0.014 13.6 17.5 1.3 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Homeodomain PF00046.29 KII64704.1 - 0.024 14.5 0.6 0.091 12.6 0.5 2.2 1 1 0 1 1 1 0 Homeodomain GPS2_interact PF15784.5 KII64704.1 - 0.035 14.6 4.8 0.12 12.9 3.5 2.3 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain HHA PF05321.11 KII64704.1 - 0.12 12.7 0.2 0.12 12.7 0.2 2.8 3 0 0 3 3 3 0 Haemolysin expression modulating protein Tropomyosin_1 PF12718.7 KII64704.1 - 0.16 12.1 19.8 0.05 13.8 6.8 2.8 1 1 1 2 2 2 0 Tropomyosin like SlyX PF04102.12 KII64704.1 - 0.28 11.8 3.9 0.79 10.4 1.9 2.6 1 1 1 2 2 2 0 SlyX Helicase_C PF00271.31 KII64704.1 - 0.65 10.4 3.9 0.76 10.1 1.8 2.0 1 1 1 2 2 2 0 Helicase conserved C-terminal domain Hemagglutinin PF00509.18 KII64704.1 - 0.93 7.8 6.1 1.1 7.6 6.1 1.2 1 0 0 1 1 1 0 Haemagglutinin Atg14 PF10186.9 KII64704.1 - 1.6 7.7 16.1 2.3 7.2 10.0 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_TATA_bd PF12325.8 KII64704.1 - 5.4 7.3 18.1 1.5 9.1 7.7 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding RUN PF02759.19 KII64705.1 - 5.2e-05 23.2 0.0 8e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 RUN domain PXA PF02194.15 KII64706.1 - 1.9e-26 93.2 4.4 7.4e-26 91.2 4.4 2.0 1 0 0 1 1 1 1 PXA domain PX PF00787.24 KII64706.1 - 3.3e-16 59.3 0.9 1.3e-15 57.4 0.9 2.0 1 0 0 1 1 1 1 PX domain Nexin_C PF08628.12 KII64706.1 - 3.8e-14 53.2 0.1 1.5e-13 51.3 0.0 2.1 2 0 0 2 2 2 1 Sorting nexin C terminal I-set PF07679.16 KII64707.1 - 1.3e-07 31.6 0.1 1.9e-07 31.1 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KII64707.1 - 2.9e-06 27.8 0.1 4.3e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KII64707.1 - 2.3e-05 24.5 0.5 6e-05 23.2 0.5 1.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 KII64707.1 - 0.0009 19.5 0.2 0.0014 18.9 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 KII64707.1 - 0.0046 16.7 0.7 0.0065 16.2 0.7 1.2 1 0 0 1 1 1 1 Adenovirus E3 region protein CR1 ig PF00047.25 KII64707.1 - 0.0047 17.1 1.3 0.008 16.3 1.3 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Receptor_2B4 PF11465.8 KII64707.1 - 0.062 13.5 0.2 0.088 13.0 0.2 1.3 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 Ig_3 PF13927.6 KII64708.1 - 0.022 15.3 0.3 0.03 14.9 0.3 1.2 1 0 0 1 1 1 0 Immunoglobulin domain CBM_15 PF03426.14 KII64708.1 - 0.058 13.0 0.1 9.3 5.8 0.0 2.1 2 0 0 2 2 2 0 Carbohydrate binding domain (family 15) I-set PF07679.16 KII64708.1 - 0.081 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain CENP-B_N PF04218.13 KII64710.1 - 8.7e-05 22.1 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_IclR PF09339.10 KII64710.1 - 0.0066 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain LacI PF00356.21 KII64710.1 - 0.012 15.4 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_psq PF05225.16 KII64710.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_3 PF01381.22 KII64710.1 - 0.029 14.4 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix HTH_Crp_2 PF13545.6 KII64710.1 - 0.036 14.1 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain DUF977 PF06163.11 KII64710.1 - 0.039 13.9 0.0 0.047 13.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) HTH_10 PF04967.12 KII64710.1 - 0.072 12.9 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain DnaJ PF00226.31 KII64711.1 - 6.1e-23 80.7 0.2 1.8e-22 79.2 0.2 1.9 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_2 PF12756.7 KII64711.1 - 2.6e-07 30.9 5.5 0.0042 17.4 1.8 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 KII64711.1 - 1.8e-06 28.3 3.7 0.059 14.2 0.5 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KII64711.1 - 0.00027 21.2 7.4 0.053 14.0 1.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 KII64711.1 - 0.00027 21.2 8.3 0.0035 17.7 1.8 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KII64711.1 - 0.0044 17.3 2.3 0.0044 17.3 2.3 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 KII64711.1 - 0.027 15.1 1.5 3.7 8.2 0.5 3.1 3 0 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-DBF PF07535.12 KII64711.1 - 0.15 12.1 3.0 0.28 11.3 1.0 2.4 2 0 0 2 2 2 0 DBF zinc finger zf-C2H2_6 PF13912.6 KII64711.1 - 2.2 8.4 5.0 25 5.0 1.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Es2 PF09751.9 KII64712.1 - 4.3e-48 165.1 15.6 6.3e-33 115.2 0.5 3.0 2 1 1 3 3 3 2 Nuclear protein Es2 DUF5345 PF17280.2 KII64712.1 - 0.17 11.8 0.6 25 4.9 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5345) DUF4371 PF14291.6 KII64713.1 - 3e-09 36.9 0.1 3e-09 36.9 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) AAA_lid_3 PF17862.1 KII64714.1 - 3.4e-15 55.6 0.2 6.2e-14 51.5 0.2 2.4 1 1 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 KII64714.1 - 4.2e-10 39.5 0.0 6.9e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA PF00004.29 KII64714.1 - 2.7e-07 31.1 1.0 3.2e-05 24.3 0.0 2.5 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) MHCassoc_trimer PF08831.10 KII64714.1 - 0.012 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain Sec1 PF00995.23 KII64715.1 - 1.2e-32 113.9 1.7 1.4e-32 113.7 1.7 1.0 1 0 0 1 1 1 1 Sec1 family Sec1 PF00995.23 KII64716.1 - 3.2e-24 86.1 2.7 3.5e-24 86.0 2.7 1.0 1 0 0 1 1 1 1 Sec1 family Kri1 PF05178.12 KII64717.1 - 0.032 14.8 0.1 0.072 13.7 0.1 1.6 1 0 0 1 1 1 0 KRI1-like family CRISPR_Cse1 PF09481.10 KII64717.1 - 0.036 13.2 0.0 0.046 12.8 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) SH3_1 PF00018.28 KII64717.1 - 0.12 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 SH3 domain LIM PF00412.22 KII64718.1 - 6.1e-05 23.2 3.7 0.00017 21.7 3.7 1.7 1 1 0 1 1 1 1 LIM domain DUF2175 PF09943.9 KII64718.1 - 7.5 6.9 7.2 13 6.2 0.5 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) MULE PF10551.9 KII64719.1 - 0.055 13.9 0.0 0.09 13.2 0.0 1.4 1 0 0 1 1 1 0 MULE transposase domain DUF2408 PF10303.9 KII64721.1 - 0.0023 18.5 2.4 0.0023 18.5 2.4 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2408) DUF948 PF06103.11 KII64721.1 - 0.014 15.6 1.4 0.025 14.8 1.2 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) UPF0242 PF06785.11 KII64721.1 - 0.042 14.0 3.9 0.066 13.3 3.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HIP1_clath_bdg PF16515.5 KII64721.1 - 0.058 14.0 3.1 0.071 13.7 1.9 1.8 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc29 PF17082.5 KII64721.1 - 0.061 13.2 6.4 0.13 12.1 3.5 1.9 1 1 1 2 2 2 0 Spindle Pole Component 29 Baculo_PEP_C PF04513.12 KII64721.1 - 0.072 13.1 1.3 0.13 12.3 1.3 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF848 PF05852.11 KII64721.1 - 0.13 12.4 2.8 0.18 11.9 2.4 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) TMPIT PF07851.13 KII64721.1 - 0.19 10.9 3.1 0.22 10.8 3.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein Prefoldin PF02996.17 KII64721.1 - 0.2 11.6 8.1 8.6 6.3 1.5 3.1 2 1 1 3 3 3 0 Prefoldin subunit DUF1664 PF07889.12 KII64721.1 - 3.8 7.6 6.6 2.1 8.4 4.3 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DDE_Tnp_IS1595 PF12762.7 KII64722.1 - 1.4e-10 41.3 0.1 9.6e-10 38.7 0.1 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain zf-BED PF02892.15 KII64722.1 - 5.4 7.1 8.9 3.7 7.7 1.1 3.0 1 1 1 2 2 2 0 BED zinc finger CEBP_ZZ PF16366.5 KII64722.1 - 7.5 6.9 11.7 3 8.2 5.0 2.5 1 1 1 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain CTP_transf_like PF01467.26 KII64726.1 - 1.4e-28 99.9 0.0 3.1e-22 79.3 0.0 2.1 2 0 0 2 2 2 2 Cytidylyltransferase-like ISK_Channel PF02060.15 KII64727.1 - 0.047 13.4 1.7 0.41 10.4 0.1 2.0 1 1 1 2 2 2 0 Slow voltage-gated potassium channel Ninjurin PF04923.12 KII64727.1 - 0.07 13.1 0.1 0.19 11.6 0.1 1.8 1 1 0 1 1 1 0 Ninjurin Dimer_Tnp_hAT PF05699.14 KII64728.1 - 9.5e-16 57.4 0.4 1.8e-15 56.5 0.4 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ldl_recept_a PF00057.18 KII64731.1 - 1.5e-11 44.3 31.6 4.7e-06 26.7 12.0 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A AAT PF03417.16 KII64731.1 - 0.17 11.6 0.1 0.22 11.2 0.1 1.1 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Retrotrans_gag PF03732.17 KII64734.1 - 5.2e-05 23.4 0.0 0.00012 22.2 0.0 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 KII64734.1 - 0.003 17.6 2.9 0.003 17.6 2.9 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.6 KII64734.1 - 0.029 14.1 1.5 0.029 14.1 1.5 1.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 KII64734.1 - 0.041 13.6 1.1 0.095 12.4 1.1 1.6 1 0 0 1 1 1 0 Zinc knuckle GATA PF00320.27 KII64739.1 - 7.8e-13 47.8 2.5 7.8e-13 47.8 2.5 2.2 2 0 0 2 2 2 1 GATA zinc finger zf-TFIIB PF13453.6 KII64739.1 - 0.0013 18.0 1.0 0.0013 18.0 1.0 2.2 2 0 0 2 2 2 1 Transcription factor zinc-finger TF_Zn_Ribbon PF08271.12 KII64739.1 - 0.03 13.8 12.4 0.12 11.9 2.1 3.2 2 1 1 3 3 3 0 TFIIB zinc-binding DZR PF12773.7 KII64739.1 - 0.2 11.7 9.9 1.5 8.9 10.0 2.4 1 1 0 1 1 1 0 Double zinc ribbon Cytochrom_c3_2 PF14537.6 KII64739.1 - 1.1 9.7 6.3 3 8.4 6.3 1.7 1 0 0 1 1 1 0 Cytochrome c3 C1_1 PF00130.22 KII64739.1 - 2.2 8.3 9.3 0.66 9.9 1.4 2.8 1 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_L37ae PF01780.19 KII64739.1 - 2.5 8.2 8.5 1 9.5 0.4 2.5 1 1 1 2 2 2 0 Ribosomal L37ae protein family eIF-5_eIF-2B PF01873.17 KII64739.1 - 3.5 7.5 10.6 7.1 6.5 3.5 2.6 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Nudix_N_2 PF14803.6 KII64739.1 - 4 7.4 10.4 9.2 6.3 2.1 3.6 3 1 0 3 3 3 0 Nudix N-terminal Zn_Tnp_IS1595 PF12760.7 KII64739.1 - 5 7.2 13.1 11 6.0 2.0 2.7 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Prim_Zn_Ribbon PF08273.12 KII64739.1 - 7.4 6.9 11.5 15 6.0 0.1 3.8 4 0 0 4 4 4 0 Zinc-binding domain of primase-helicase zf-ribbon_3 PF13248.6 KII64739.1 - 8.5 5.9 16.0 15 5.1 0.2 4.7 4 0 0 4 4 4 0 zinc-ribbon domain DDE_3 PF13358.6 KII64740.1 - 0.028 14.2 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease CAML PF14963.6 KII64740.1 - 0.031 14.4 0.1 0.036 14.2 0.1 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand zf-TFIIB PF13453.6 KII64742.1 - 0.0059 15.9 0.2 0.0099 15.2 0.2 1.3 1 0 0 1 1 1 1 Transcription factor zinc-finger zinc_ribbon_10 PF10058.9 KII64742.1 - 0.045 13.5 3.6 0.098 12.4 3.6 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein DDE_Tnp_IS1595 PF12762.7 KII64743.1 - 1.2e-19 70.8 0.0 1.6e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain gag-asp_proteas PF13975.6 KII64744.1 - 7.3e-08 32.9 0.0 1.7e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.17 KII64744.1 - 0.00012 22.3 0.1 0.00032 20.9 0.1 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein Asp_protease_2 PF13650.6 KII64744.1 - 0.00013 22.5 0.0 0.0003 21.3 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII64744.1 - 0.00022 21.5 0.2 0.0028 17.9 0.1 2.6 2 1 0 2 2 2 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII64744.1 - 0.00075 19.3 0.2 0.002 17.9 0.2 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII64744.1 - 0.00076 19.4 1.1 0.0014 18.7 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle Peptidase_A2E PF12382.8 KII64744.1 - 0.0019 18.2 0.0 0.0035 17.3 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon peptidase zf-CCHC_5 PF14787.6 KII64744.1 - 0.014 15.1 1.4 0.023 14.4 1.4 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RVP_2 PF08284.11 KII64744.1 - 0.08 12.7 0.3 0.23 11.3 0.3 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease Arc_C PF18162.1 KII64744.1 - 0.097 12.5 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Arc C-lobe zf-CCHC_2 PF13696.6 KII64744.1 - 0.19 11.6 1.5 0.42 10.5 1.5 1.6 1 0 0 1 1 1 0 Zinc knuckle SlyX PF04102.12 KII64744.1 - 0.23 12.1 0.3 0.23 12.1 0.3 2.3 2 0 0 2 2 2 0 SlyX PSP PF04046.16 KII64745.1 - 3.6e-15 55.5 0.2 7.3e-15 54.6 0.2 1.5 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.23 KII64745.1 - 0.0014 18.7 1.5 0.0023 17.9 1.5 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 KII64745.1 - 0.042 13.7 0.9 0.089 12.6 0.9 1.6 1 0 0 1 1 1 0 Zinc knuckle Bromodomain PF00439.25 KII64746.1 - 7.7e-42 141.3 0.2 7.5e-20 70.8 0.1 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KII64746.1 - 1.4e-08 34.8 0.8 5.4e-08 32.9 0.6 2.2 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation SPACA9 PF15120.6 KII64746.1 - 0.017 14.9 1.9 0.084 12.7 0.2 2.5 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 CTD PF12815.7 KII64746.1 - 6.8 7.3 7.1 98 3.6 6.0 3.1 2 1 0 2 2 2 0 Spt5 C-terminal nonapeptide repeat binding Spt4 DDE_3 PF13358.6 KII64747.1 - 4.8e-26 91.3 0.0 7.5e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.11 KII64747.1 - 0.00064 18.8 0.0 0.89 8.5 0.0 2.2 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain HTH_23 PF13384.6 KII64747.1 - 0.0012 18.6 0.1 0.015 15.1 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII64747.1 - 0.0037 17.5 0.2 0.0097 16.1 0.2 1.7 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.6 KII64747.1 - 0.025 14.6 0.2 0.51 10.4 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn helix rve PF00665.26 KII64747.1 - 0.035 14.3 0.0 0.059 13.6 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain HTH_7 PF02796.15 KII64747.1 - 0.052 13.6 0.6 0.27 11.4 0.2 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.16 KII64747.1 - 0.054 13.5 0.7 0.13 12.4 0.7 1.6 1 1 0 1 1 1 0 Transposase HTH_11 PF08279.12 KII64747.1 - 0.073 13.0 0.4 4.6 7.3 0.0 2.5 2 0 0 2 2 2 0 HTH domain GerE PF00196.19 KII64747.1 - 0.089 12.3 1.2 0.3 10.7 0.2 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_36 PF13730.6 KII64747.1 - 0.14 12.1 2.6 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Myb_DNA-bind_5 PF13873.6 KII64749.1 - 8.3e-10 38.6 2.9 1.7e-09 37.6 2.9 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.31 KII64749.1 - 0.0023 18.1 0.2 0.0054 16.9 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII64749.1 - 0.0088 16.3 0.8 0.016 15.4 0.8 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.7 KII64749.1 - 0.031 15.3 1.7 0.05 14.6 1.7 1.4 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Galactosyl_T PF01762.21 KII64751.1 - 2.1e-29 102.8 0.8 2.8e-29 102.3 0.8 1.1 1 0 0 1 1 1 1 Galactosyltransferase PHD20L1_u1 PF16660.5 KII64753.1 - 0.067 13.9 0.7 0.14 12.9 0.7 1.5 1 0 0 1 1 1 0 PHD finger protein 20-like protein 1 Translat_reg PF01818.17 KII64755.1 - 0.11 12.5 1.9 3 7.8 0.1 3.1 3 0 0 3 3 3 0 Bacteriophage translational regulator Vg_Tdu PF07545.14 KII64761.1 - 1.8e-10 40.4 30.8 9.7 6.1 0.1 10.1 10 0 0 10 10 10 9 Vestigial/Tondu family DUF1505 PF07403.11 KII64761.1 - 3e-06 27.4 23.4 57 3.9 0.0 9.6 10 0 0 10 10 10 0 Protein of unknown function (DUF1505) PRANC PF09372.10 KII64761.1 - 7.1e-06 26.3 8.3 3e+02 1.8 0.0 10.1 11 0 0 11 11 11 0 PRANC domain DNase_NucA_NucB PF14040.6 KII64761.1 - 0.00066 20.0 37.2 68 3.9 0.1 10.7 11 0 0 11 11 11 0 Deoxyribonuclease NucA/NucB DnaGprimase_HBD PF16730.5 KII64761.1 - 0.23 11.5 0.2 0.38 10.8 0.2 1.3 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain DUF3894 PF13033.6 KII64766.1 - 0.066 13.3 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3894) SET PF00856.28 KII64767.1 - 6.2e-05 23.4 3.3 0.00022 21.7 3.3 1.9 1 1 0 1 1 1 1 SET domain Integrase_H2C2 PF17921.1 KII64771.1 - 2.5e-08 33.9 0.0 4.9e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain Ldl_recept_a PF00057.18 KII64772.1 - 9.7e-09 35.3 15.0 9.7e-09 35.3 15.0 2.6 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A SH3_6 PF12913.7 KII64773.1 - 0.0031 17.0 0.1 0.0055 16.2 0.1 1.4 1 0 0 1 1 1 1 SH3 domain (SH3b1 type) gag-asp_proteas PF13975.6 KII64775.1 - 7.3e-11 42.5 0.0 2e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII64775.1 - 6.5e-08 33.1 0.0 1.4e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 KII64775.1 - 4.4e-06 26.5 0.4 1.5e-05 24.8 0.1 2.0 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.20 KII64775.1 - 0.0036 17.6 0.0 0.013 15.8 0.0 2.0 1 1 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KII64775.1 - 0.016 15.0 0.1 0.041 13.6 0.1 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF1043 PF06295.12 KII64775.1 - 0.47 10.5 3.7 15 5.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Prefoldin PF02996.17 KII64775.1 - 2.7 7.9 6.5 14 5.6 0.1 2.6 2 0 0 2 2 2 0 Prefoldin subunit zf-CCHC_4 PF14392.6 KII64775.1 - 4.9 7.0 10.3 0.73 9.6 0.9 2.6 2 0 0 2 2 2 0 Zinc knuckle NHL PF01436.21 KII64780.1 - 4.9e-18 64.2 3.2 1.5e-05 24.8 0.0 5.3 5 0 0 5 5 5 3 NHL repeat Filamin PF00630.19 KII64780.1 - 1e-13 52.0 0.0 3.4e-13 50.3 0.0 2.0 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-C3HC4_4 PF15227.6 KII64780.1 - 1.9e-11 43.9 9.5 1.9e-11 43.9 9.5 3.0 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KII64780.1 - 1.8e-09 37.4 9.3 1.8e-09 37.4 9.3 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-B_box PF00643.24 KII64780.1 - 7.2e-09 35.7 6.7 7.2e-09 35.7 6.7 3.2 4 0 0 4 4 3 1 B-box zinc finger zf-C3HC4 PF00097.25 KII64780.1 - 4.5e-08 32.8 9.4 4.5e-08 32.8 9.4 2.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KII64780.1 - 6.8e-08 32.2 10.5 6.8e-08 32.2 10.5 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII64780.1 - 3.2e-06 27.4 10.1 3.2e-06 27.4 10.1 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 KII64780.1 - 8.4e-06 25.6 8.8 8.4e-06 25.6 8.8 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SGL PF08450.12 KII64780.1 - 0.00031 20.4 0.2 0.56 9.7 0.0 3.0 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region zf-RING_5 PF14634.6 KII64780.1 - 0.00043 20.2 8.5 0.00043 20.2 8.5 2.8 2 0 0 2 2 1 1 zinc-RING finger domain DUF5128 PF17170.4 KII64780.1 - 0.0017 17.5 3.1 0.003 16.8 0.0 2.8 3 0 0 3 3 3 1 6-bladed beta-propeller zf-Nse PF11789.8 KII64780.1 - 0.44 10.4 8.4 0.18 11.6 5.0 2.2 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 KII64780.1 - 2.3 8.1 11.4 1.9 8.3 8.7 2.3 2 0 0 2 2 2 0 RING-like zinc finger Ribosomal_L34 PF00468.17 KII64781.1 - 2.6e-18 65.7 4.3 2.6e-18 65.7 4.3 1.8 1 1 1 2 2 2 1 Ribosomal protein L34 NumbF PF06311.12 KII64781.1 - 0.14 12.7 0.1 0.17 12.4 0.1 1.2 1 0 0 1 1 1 0 NUMB domain FAST_1 PF06743.15 KII64783.1 - 0.057 13.4 1.1 1 9.4 0.0 3.7 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 SfsA PF03749.13 KII64783.1 - 0.077 12.9 0.1 0.19 11.6 0.1 1.7 1 0 0 1 1 1 0 Sugar fermentation stimulation protein RE domain Phage_DsbA PF11126.8 KII64783.1 - 0.19 12.0 2.3 9.3 6.5 0.0 3.6 3 0 0 3 3 3 0 Transcriptional regulator DsbA DUF4041 PF13250.6 KII64783.1 - 0.35 10.8 4.1 6.7 6.7 0.1 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4041) RED_C PF07807.11 KII64784.1 - 0.14 12.6 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 RED-like protein C-terminal region GED PF02212.18 KII64785.1 - 3.6 7.8 6.1 6.7 6.9 0.4 3.6 2 1 1 3 3 3 0 Dynamin GTPase effector domain RT_RNaseH_2 PF17919.1 KII64786.1 - 1.2e-09 38.1 0.0 1.8e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-UBR PF02207.20 KII64787.1 - 0.25 11.5 20.0 0.59 10.3 20.0 1.7 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) RED_C PF07807.11 KII64789.1 - 0.16 12.5 0.0 0.36 11.3 0.0 1.5 1 0 0 1 1 1 0 RED-like protein C-terminal region Lactamase_B_6 PF16661.5 KII64793.1 - 0.036 13.5 0.5 0.036 13.5 0.5 2.4 1 1 2 3 3 3 0 Metallo-beta-lactamase superfamily domain DUF4573 PF15140.6 KII64793.1 - 0.038 13.8 2.0 0.081 12.7 2.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4573) RVT_1 PF00078.27 KII64797.1 - 9.5e-24 84.1 0.1 1.5e-23 83.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1759 PF03564.15 KII64797.1 - 0.11 12.4 0.0 3.6 7.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) DHR10 PF18595.1 KII64798.1 - 0.00017 21.6 6.0 0.00017 21.6 6.0 2.1 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain AAA_13 PF13166.6 KII64798.1 - 0.0003 19.6 6.0 0.0004 19.2 6.0 1.2 1 0 0 1 1 1 1 AAA domain DUF812 PF05667.11 KII64798.1 - 0.0013 17.7 5.9 0.0016 17.5 5.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Sec8_exocyst PF04048.14 KII64798.1 - 0.002 18.0 10.6 0.0052 16.7 3.1 2.3 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain UPF0242 PF06785.11 KII64798.1 - 0.0021 18.2 9.7 0.0026 17.9 9.7 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Fez1 PF06818.15 KII64798.1 - 0.0036 17.8 10.6 0.0062 17.0 10.6 1.4 1 1 0 1 1 1 1 Fez1 DLP_helical PF18709.1 KII64798.1 - 0.0043 16.3 4.2 0.0043 16.3 4.2 2.0 1 1 1 2 2 2 1 Dynamin-like helical domain DUF4200 PF13863.6 KII64798.1 - 0.0056 17.1 10.7 0.01 16.2 3.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) DUF2730 PF10805.8 KII64798.1 - 0.0056 16.7 4.3 0.036 14.2 0.5 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2730) Spc7 PF08317.11 KII64798.1 - 0.006 15.5 13.0 0.013 14.4 4.8 2.1 2 0 0 2 2 2 1 Spc7 kinetochore protein DUF1664 PF07889.12 KII64798.1 - 0.0064 16.5 2.3 0.0064 16.5 2.3 2.5 3 0 0 3 3 2 1 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 KII64798.1 - 0.0079 16.9 12.2 0.25 12.1 5.4 2.6 1 1 0 2 2 2 1 Occludin homology domain APG6_N PF17675.1 KII64798.1 - 0.01 16.4 14.3 0.08 13.5 5.3 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Laminin_II PF06009.12 KII64798.1 - 0.02 14.9 7.9 0.067 13.2 2.5 2.3 2 0 0 2 2 2 0 Laminin Domain II COG5 PF10392.9 KII64798.1 - 0.021 15.0 3.8 0.021 15.0 3.8 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 ATG16 PF08614.11 KII64798.1 - 0.023 15.0 16.0 0.18 12.0 8.1 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1192 PF06698.11 KII64798.1 - 0.024 14.7 0.8 0.057 13.5 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Rogdi_lz PF10259.9 KII64798.1 - 0.028 13.9 3.5 0.035 13.6 3.2 1.3 1 1 0 1 1 1 0 Rogdi leucine zipper containing protein NPV_P10 PF05531.12 KII64798.1 - 0.036 14.5 13.6 0.12 12.9 3.4 2.5 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Vps5 PF09325.10 KII64798.1 - 0.04 13.5 9.2 0.045 13.3 3.1 2.1 2 0 0 2 2 2 0 Vps5 C terminal like COG2 PF06148.11 KII64798.1 - 0.042 13.9 8.9 0.56 10.3 0.4 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Exonuc_VII_L PF02601.15 KII64798.1 - 0.043 13.4 5.2 0.047 13.2 5.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ntox28 PF15605.6 KII64798.1 - 0.043 14.1 3.6 0.54 10.5 0.1 2.2 2 0 0 2 2 2 0 Bacterial toxin 28 DUF4407 PF14362.6 KII64798.1 - 0.045 13.1 4.7 0.067 12.5 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 KII64798.1 - 0.048 14.0 13.1 0.1 12.9 13.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) EzrA PF06160.12 KII64798.1 - 0.085 11.0 18.2 0.079 11.1 8.6 2.1 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA DUF4315 PF14193.6 KII64798.1 - 0.09 12.8 0.9 0.09 12.8 0.9 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4315) TssO PF17561.2 KII64798.1 - 0.11 12.6 11.2 0.18 11.9 11.2 1.5 1 0 0 1 1 1 0 Type VI secretion system, TssO FlxA PF14282.6 KII64798.1 - 0.11 12.5 19.1 0.22 11.6 8.0 2.4 2 0 0 2 2 2 0 FlxA-like protein TMPIT PF07851.13 KII64798.1 - 0.12 11.6 12.9 0.037 13.3 6.2 2.0 1 1 0 1 1 1 0 TMPIT-like protein ZapB PF06005.12 KII64798.1 - 0.13 12.7 20.9 24 5.5 20.9 2.2 1 1 0 1 1 1 0 Cell division protein ZapB kleA_kleC PF17383.2 KII64798.1 - 0.14 12.5 0.3 0.3 11.5 0.3 1.5 1 0 0 1 1 1 0 Uncharacterized KorC regulated protein A DivIC PF04977.15 KII64798.1 - 0.16 11.7 20.4 0.087 12.6 7.2 2.6 1 1 2 3 3 3 0 Septum formation initiator Acyl-CoA_dh_C PF12806.7 KII64798.1 - 0.19 11.9 0.0 0.33 11.1 0.0 1.5 1 1 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like GP41 PF00517.17 KII64798.1 - 0.19 11.6 7.7 0.27 11.1 6.2 1.8 1 1 1 2 2 2 0 Retroviral envelope protein DUF4527 PF15030.6 KII64798.1 - 0.22 10.9 6.0 0.42 10.0 2.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4527) LMBR1 PF04791.16 KII64798.1 - 0.26 10.2 4.1 0.28 10.0 4.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TPR_MLP1_2 PF07926.12 KII64798.1 - 0.29 11.2 14.7 0.13 12.3 8.4 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein WEMBL PF05701.11 KII64798.1 - 0.3 9.7 10.0 0.53 8.9 10.0 1.3 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DUF724 PF05266.14 KII64798.1 - 0.34 10.7 13.9 2.3 8.0 13.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Folliculin PF11704.8 KII64798.1 - 0.34 10.8 5.2 0.64 9.9 5.2 1.5 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport SKA2 PF16740.5 KII64798.1 - 0.39 10.5 10.5 0.054 13.3 3.6 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 WXG100 PF06013.12 KII64798.1 - 0.39 11.0 5.8 15 5.9 3.6 3.2 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Med9 PF07544.13 KII64798.1 - 0.41 10.8 14.9 8.1 6.6 1.4 3.2 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 KELK PF15796.5 KII64798.1 - 0.42 11.1 12.1 0.98 9.9 2.1 2.9 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF2203 PF09969.9 KII64798.1 - 0.47 11.2 7.5 6.4 7.5 7.5 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) YabA PF06156.13 KII64798.1 - 0.52 11.0 15.8 9.1 7.0 15.8 2.1 1 1 0 1 1 1 0 Initiation control protein YabA BRE1 PF08647.11 KII64798.1 - 0.52 10.4 18.0 0.78 9.9 9.5 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase CHASE3 PF05227.13 KII64798.1 - 0.53 10.2 7.9 4.8 7.1 1.2 2.2 1 1 1 2 2 2 0 CHASE3 domain HBM PF16591.5 KII64798.1 - 0.53 9.7 11.7 1.4 8.3 11.7 1.6 1 1 0 1 1 1 0 Helical bimodular sensor domain ABC_tran_CTD PF16326.5 KII64798.1 - 0.55 10.5 10.2 0.11 12.8 4.1 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain Bacillus_HBL PF05791.11 KII64798.1 - 0.57 10.0 15.6 0.25 11.2 9.8 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Phage_pRha PF09669.10 KII64798.1 - 0.57 10.8 5.9 3.6 8.2 1.3 2.4 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) PI3K_P85_iSH2 PF16454.5 KII64798.1 - 0.59 9.7 15.6 0.085 12.4 7.8 2.1 1 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CENP-F_leu_zip PF10473.9 KII64798.1 - 0.65 10.0 16.8 0.076 13.0 8.7 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 KII64798.1 - 0.65 10.4 11.0 0.25 11.8 5.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) HIP1_clath_bdg PF16515.5 KII64798.1 - 0.7 10.5 14.6 0.13 12.9 5.8 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1843 PF08898.10 KII64798.1 - 0.71 10.4 8.7 0.5 10.9 0.8 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF1843) Syntaxin-6_N PF09177.11 KII64798.1 - 0.87 10.2 9.0 0.89 10.1 3.5 2.6 1 1 0 2 2 2 0 Syntaxin 6, N-terminal Atg14 PF10186.9 KII64798.1 - 0.87 8.6 17.8 0.13 11.4 8.9 1.9 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 XhlA PF10779.9 KII64798.1 - 0.93 9.7 19.6 0.059 13.6 9.6 2.3 2 0 0 2 2 2 0 Haemolysin XhlA OmpH PF03938.14 KII64798.1 - 1 9.7 16.8 20 5.5 16.8 2.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Pet100 PF09803.9 KII64798.1 - 1 9.9 4.6 0.62 10.6 0.6 2.4 2 2 0 2 2 2 0 Pet100 CENP-H PF05837.12 KII64798.1 - 1 9.8 15.6 88 3.6 15.6 2.2 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Spc24 PF08286.11 KII64798.1 - 1.1 9.6 14.9 0.3 11.4 7.1 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4140 PF13600.6 KII64798.1 - 1.1 9.7 7.6 0.8 10.2 1.2 2.6 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) Fib_alpha PF08702.10 KII64798.1 - 1.1 9.4 16.1 0.42 10.8 6.5 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family AKNA PF12443.8 KII64798.1 - 1.4 9.6 10.0 0.19 12.4 2.8 2.9 2 2 2 4 4 2 0 AT-hook-containing transcription factor DivIVA PF05103.13 KII64798.1 - 1.7 8.8 15.6 2.5 8.2 6.9 2.2 1 1 1 2 2 2 0 DivIVA protein DUF2205 PF10224.9 KII64798.1 - 1.9 8.5 12.9 0.21 11.6 7.3 2.3 2 1 0 2 2 1 0 Short coiled-coil protein AATF-Che1 PF13339.6 KII64798.1 - 2.1 9.0 12.0 7 7.3 0.9 2.3 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor DUF4164 PF13747.6 KII64798.1 - 2.2 8.6 11.3 0.33 11.2 2.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Prefoldin PF02996.17 KII64798.1 - 2.5 8.0 13.8 0.53 10.2 6.0 2.5 2 1 0 2 2 2 0 Prefoldin subunit IL5 PF02025.15 KII64798.1 - 2.6 8.4 10.2 13 6.1 0.7 2.9 1 1 2 3 3 3 0 Interleukin 5 HAUS6_N PF14661.6 KII64798.1 - 2.6 7.6 11.6 33 3.9 11.6 2.0 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Csm1_N PF18504.1 KII64798.1 - 2.9 8.3 16.0 0.48 10.8 7.0 2.5 2 1 0 2 2 2 0 Csm1 N-terminal domain CorA PF01544.18 KII64798.1 - 2.9 7.1 10.2 3.9 6.7 10.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein SlyX PF04102.12 KII64798.1 - 3.1 8.5 12.5 0.4 11.3 4.4 2.3 2 0 0 2 2 2 0 SlyX Swi5 PF07061.11 KII64798.1 - 3.2 7.9 13.4 1.1 9.3 6.9 2.4 2 0 0 2 2 2 0 Swi5 PspA_IM30 PF04012.12 KII64798.1 - 4.3 6.8 12.9 3.6 7.1 5.0 2.0 1 1 0 2 2 2 0 PspA/IM30 family betaPIX_CC PF16523.5 KII64798.1 - 4.9 7.1 11.4 2.4 8.0 2.3 2.2 2 0 0 2 2 2 0 betaPIX coiled coil DUF16 PF01519.16 KII64798.1 - 5.1 7.6 14.8 1.3 9.5 6.7 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Phage_GPO PF05929.11 KII64798.1 - 6.7 6.3 8.7 3 7.4 2.3 2.0 1 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase GrpE PF01025.19 KII64798.1 - 7.1 6.3 14.7 50 3.5 12.0 2.2 1 1 1 2 2 2 0 GrpE DHHA1 PF02272.19 KII64798.1 - 8.6 6.8 8.8 18 5.7 1.3 2.8 2 1 1 3 3 3 0 DHHA1 domain DUF4298 PF14131.6 KII64798.1 - 8.8 6.4 10.6 15 5.6 0.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) Fer4_21 PF14697.6 KII64800.1 - 0.017 15.3 6.1 0.041 14.0 6.1 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain zf-C2H2_12 PF18658.1 KII64800.1 - 0.096 12.3 1.6 0.19 11.3 1.6 1.5 1 0 0 1 1 1 0 Zinc-finger C2H2-type zf-C2H2_4 PF13894.6 KII64800.1 - 1.6 9.8 14.1 3.3 8.8 4.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger RVT_1 PF00078.27 KII64801.1 - 2.6e-13 50.0 0.0 3e-13 49.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 KII64802.1 - 3e-05 23.7 0.0 3.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EC042_2821 PF18740.1 KII64802.1 - 0.036 14.0 0.0 0.044 13.7 0.0 1.1 1 0 0 1 1 1 0 EC042_2821-lke REase Uds1 PF15456.6 KII64803.1 - 0.05 13.8 0.1 0.055 13.6 0.1 1.1 1 0 0 1 1 1 0 Up-regulated During Septation zf-RVT PF13966.6 KII64804.1 - 0.15 12.8 0.2 0.27 12.0 0.2 1.5 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase RT_RNaseH_2 PF17919.1 KII64807.1 - 8e-18 64.3 0.0 1.7e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64807.1 - 4.2e-11 43.1 0.1 1.8e-10 41.0 0.0 2.1 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64807.1 - 0.0033 17.0 0.0 0.0079 15.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4070 PF13282.6 KII64808.1 - 0.005 17.0 0.8 0.02 15.0 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4070) HbrB PF08539.11 KII64808.1 - 0.074 13.0 1.3 0.13 12.3 0.2 1.9 2 0 0 2 2 2 0 HbrB-like FA_FANCE PF11510.8 KII64809.1 - 0.015 14.7 0.0 0.019 14.3 0.0 1.1 1 0 0 1 1 1 0 Fanconi Anaemia group E protein FANCE Ubiquitin_3 PF14836.6 KII64809.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain Evr1_Alr PF04777.13 KII64809.1 - 0.17 12.4 0.7 0.73 10.3 0.1 2.0 1 1 1 2 2 2 0 Erv1 / Alr family DNA_pol_A_exo1 PF01612.20 KII64810.1 - 0.013 15.2 0.3 0.029 14.1 0.3 1.5 1 0 0 1 1 1 0 3'-5' exonuclease SF3A3 PF16837.5 KII64810.1 - 6.4 7.4 7.8 0.34 11.5 0.9 2.4 3 0 0 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 rve PF00665.26 KII64811.1 - 1.4e-15 57.6 0.0 2.4e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII64811.1 - 1.5e-05 24.7 0.0 3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 KII64812.1 - 2.3e-36 124.3 0.0 4.5e-36 123.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII64812.1 - 1e-35 121.7 0.0 2e-35 120.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Retrotran_gag_2 PF14223.6 KII64812.1 - 0.00044 19.9 0.2 0.0012 18.5 0.0 1.8 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC_3 PF13917.6 KII64812.1 - 0.0027 17.6 13.7 0.042 13.8 3.3 2.4 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 KII64812.1 - 0.0028 17.6 1.2 0.0028 17.6 1.2 2.8 2 0 0 2 2 1 1 Zinc knuckle DUF5082 PF16888.5 KII64812.1 - 0.02 15.1 0.0 0.74 10.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) HTH_Tnp_1 PF01527.20 KII64812.1 - 0.04 14.2 0.2 0.69 10.3 0.0 2.6 2 0 0 2 2 2 0 Transposase gag-asp_proteas PF13975.6 KII64812.1 - 0.1 13.2 0.0 0.31 11.6 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII64812.1 - 0.12 13.0 0.0 0.34 11.6 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease DUF1192 PF06698.11 KII64812.1 - 0.19 11.8 2.3 1.1 9.4 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) FlaC_arch PF05377.11 KII64812.1 - 0.26 11.7 2.2 0.93 9.9 1.1 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Augurin PF15187.6 KII64816.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Oesophageal cancer-related gene 4 RVT_1 PF00078.27 KII64819.1 - 0.02 14.4 0.1 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_4 PF13894.6 KII64821.1 - 0.0047 17.7 0.5 0.0047 17.7 0.5 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-Di19 PF05605.12 KII64821.1 - 0.062 13.6 1.4 0.071 13.4 0.1 1.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 KII64821.1 - 0.44 10.9 4.3 3.6 8.0 4.3 2.3 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KII64821.1 - 1.2 9.7 7.8 0.59 10.7 3.3 2.5 2 1 0 2 2 2 0 Zinc finger, C2H2 type RVT_1 PF00078.27 KII64822.1 - 4.6e-12 45.9 0.0 8.5e-12 45.1 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mononeg_RNA_pol PF00946.19 KII64824.1 - 0.17 9.5 0.0 0.21 9.2 0.0 1.0 1 0 0 1 1 1 0 Mononegavirales RNA dependent RNA polymerase DDE_Tnp_IS1595 PF12762.7 KII64825.1 - 9.3e-15 54.9 0.0 1.4e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII64826.1 - 2.7e-05 24.2 0.0 7.4e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII64827.1 - 8.5e-07 29.1 0.0 1.1e-06 28.8 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.14 KII64827.1 - 0.043 13.3 0.0 0.054 13.0 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family Integrase_H2C2 PF17921.1 KII64828.1 - 1.3e-18 66.9 0.5 3.1e-18 65.6 0.5 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII64828.1 - 9.7e-18 64.5 0.0 2.4e-17 63.2 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII64828.1 - 0.0004 20.5 0.0 0.0016 18.6 0.0 2.0 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII64828.1 - 0.027 14.2 0.0 0.064 13.0 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain TPR_8 PF13181.6 KII64830.1 - 1.8e-06 27.7 6.8 0.33 11.3 0.2 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 KII64830.1 - 8.3e-05 22.7 1.1 0.58 10.7 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII64830.1 - 0.014 15.5 7.6 5.2 7.4 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat ChAPs PF09295.10 KII64830.1 - 0.028 13.4 0.0 0.14 11.1 0.0 2.2 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_1 PF00515.28 KII64830.1 - 0.062 13.2 10.6 13 5.8 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 KII64830.1 - 0.069 13.7 1.8 13 6.4 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat YbaJ PF10757.9 KII64830.1 - 0.077 13.5 0.7 1.9 9.0 0.0 3.0 2 2 2 4 4 4 0 Biofilm formation regulator YbaJ Coatomer_E PF04733.14 KII64830.1 - 0.15 11.4 1.9 22 4.4 0.1 3.0 3 0 0 3 3 3 0 Coatomer epsilon subunit DDE_3 PF13358.6 KII64831.1 - 1e-06 28.6 0.2 3.7e-06 26.7 0.1 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease PNMA PF14893.6 KII64833.1 - 0.051 13.0 0.0 0.074 12.4 0.0 1.3 1 1 0 1 1 1 0 PNMA FERM_C PF09380.10 KII64834.1 - 0.029 14.8 0.0 0.077 13.4 0.0 1.7 1 0 0 1 1 1 0 FERM C-terminal PH-like domain Phe_tRNA-synt_N PF02912.18 KII64834.1 - 0.029 14.3 0.1 0.095 12.6 0.1 1.8 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain TBK1_ULD PF18396.1 KII64834.1 - 0.38 10.7 2.1 3.3 7.7 0.1 3.0 3 0 0 3 3 3 0 TANK binding kinase 1 ubiquitin-like domain YtxH PF12732.7 KII64834.1 - 0.48 11.0 1.8 8 7.1 0.1 3.0 2 1 0 2 2 2 0 YtxH-like protein Kinesin PF00225.23 KII64835.1 - 1.1e-60 205.3 2.4 1.1e-60 205.3 2.4 3.8 2 2 0 2 2 2 1 Kinesin motor domain PRP38 PF03371.15 KII64837.1 - 8.6e-52 175.5 0.0 1.2e-51 175.1 0.0 1.2 1 0 0 1 1 1 1 PRP38 family DUF1764 PF08576.10 KII64837.1 - 5 8.1 10.0 8.9 7.3 10.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) U3_assoc_6 PF08640.11 KII64838.1 - 7.8e-12 45.1 5.3 2.1e-11 43.7 5.3 1.7 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 TMEM247 PF15444.6 KII64839.1 - 3.6 7.6 10.0 0.18 11.8 3.5 1.9 2 0 0 2 2 2 0 Transmembrane protein 247 SRP40_C PF05022.12 KII64840.1 - 6.9e-14 52.5 4.7 9.7e-14 52.0 2.1 2.7 2 0 0 2 2 2 1 SRP40, C-terminal domain DDE_3 PF13358.6 KII64841.1 - 4.6e-12 45.9 0.1 2.2e-11 43.7 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF1357 PF07094.11 KII64842.1 - 0.0083 16.2 0.2 0.0094 16.0 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1357) DUF5344 PF17279.2 KII64842.1 - 0.05 14.2 0.7 0.064 13.8 0.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5344) KH_1 PF00013.29 KII64843.1 - 0.00013 21.7 0.0 0.087 12.7 0.0 2.1 2 0 0 2 2 2 2 KH domain HTH_23 PF13384.6 KII64844.1 - 2.9e-09 36.5 0.0 4.4e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_29 PF13551.6 KII64844.1 - 1.1e-06 28.5 0.0 0.00012 22.0 0.0 2.5 3 0 0 3 3 3 1 Winged helix-turn helix HTH_28 PF13518.6 KII64844.1 - 1.5e-05 25.0 0.0 0.0008 19.5 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 KII64844.1 - 0.00027 21.5 0.0 0.00086 19.9 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.18 KII64844.1 - 0.00055 19.9 0.3 0.0025 17.7 0.3 1.8 1 1 1 2 2 2 1 'Paired box' domain HTH_38 PF13936.6 KII64844.1 - 0.022 14.5 0.3 1.8 8.4 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.16 KII64844.1 - 0.033 14.2 0.3 0.07 13.2 0.2 1.5 1 1 1 2 2 2 0 Transposase HTH_7 PF02796.15 KII64844.1 - 0.074 13.1 2.0 0.46 10.6 0.3 2.9 3 1 0 3 3 3 0 Helix-turn-helix domain of resolvase Sigma70_r4_2 PF08281.12 KII64844.1 - 0.08 12.6 0.1 0.2 11.4 0.0 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_Tnp_Tc3_2 PF01498.18 KII64844.1 - 0.1 12.8 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_Crp_2 PF13545.6 KII64844.1 - 0.14 12.2 0.2 3.3 7.8 0.0 2.7 2 1 1 3 3 3 0 Crp-like helix-turn-helix domain Dynamin_N PF00350.23 KII64846.1 - 3.2e-54 183.5 0.0 5.4e-54 182.7 0.0 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 KII64846.1 - 4.9e-32 111.3 0.1 9e-32 110.4 0.1 1.4 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 KII64846.1 - 7e-06 26.1 0.0 1.8e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KII64846.1 - 0.0029 18.0 0.0 0.005 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 KII64846.1 - 0.1 12.8 0.0 0.3 11.3 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 KII64847.1 - 1e-08 35.6 0.2 2.4e-08 34.4 0.2 1.7 1 0 0 1 1 1 1 PH domain Dynamin_M PF01031.20 KII64847.1 - 3e-05 23.4 0.1 5.4e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 Dynamin central region GED PF02212.18 KII64847.1 - 0.0002 21.5 0.4 0.00042 20.4 0.4 1.5 1 0 0 1 1 1 1 Dynamin GTPase effector domain GDPD_2 PF13653.6 KII64847.1 - 0.0051 17.2 0.0 0.01 16.3 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Glyco_transf_54 PF04666.13 KII64849.1 - 1.6e-33 115.9 0.5 1.9e-33 115.6 0.5 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glycos_transf_2 PF00535.26 KII64849.1 - 0.00078 19.3 0.0 0.043 13.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Pkinase PF00069.25 KII64850.1 - 1.9e-52 178.2 0.0 2.6e-52 177.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII64850.1 - 2.9e-39 134.9 0.0 4.3e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 KII64850.1 - 2.2e-08 34.2 0.1 5.3e-08 33.0 0.1 1.7 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Pkinase_fungal PF17667.1 KII64850.1 - 1.1e-07 31.0 0.1 1.6e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KII64850.1 - 0.00053 19.4 0.0 0.001 18.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KII64850.1 - 0.0059 16.0 0.1 0.011 15.1 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Adenylsucc_synt PF00709.21 KII64851.1 - 1.5e-160 534.7 0.0 1.8e-160 534.5 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase KH_1 PF00013.29 KII64855.1 - 4.2e-06 26.5 4.0 0.1 12.4 0.1 3.7 4 0 0 4 4 4 2 KH domain SLS PF14611.6 KII64855.1 - 0.042 13.7 2.2 0.22 11.3 0.1 2.5 2 1 1 3 3 3 0 Mitochondrial inner-membrane-bound regulator DDE_3 PF13358.6 KII64859.1 - 9.4e-09 35.2 0.0 1.3e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Plk4_PB2 PF18409.1 KII64859.1 - 0.015 16.0 0.0 0.029 15.1 0.0 1.5 1 1 0 1 1 1 0 Polo-like Kinase 4 Polo Box 2 Pkinase PF00069.25 KII64860.1 - 1.6e-56 191.6 0.0 2.3e-56 191.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII64860.1 - 3.2e-40 138.1 0.0 5e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 KII64860.1 - 2.8e-10 40.3 0.0 6.4e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Kinase-like PF14531.6 KII64860.1 - 8.4e-05 22.0 0.0 0.00015 21.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KII64860.1 - 0.00011 21.2 0.1 0.00017 20.5 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KII64860.1 - 0.0013 18.1 0.1 0.0037 16.7 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Abi_2 PF07751.11 KII64860.1 - 0.026 14.8 0.1 0.067 13.4 0.1 1.7 1 0 0 1 1 1 0 Abi-like protein Haspin_kinase PF12330.8 KII64860.1 - 0.052 12.5 0.1 0.12 11.3 0.1 1.6 1 1 0 1 1 1 0 Haspin like kinase domain Involucrin2 PF06994.11 KII64860.1 - 0.2 11.8 3.2 0.43 10.7 3.2 1.5 1 0 0 1 1 1 0 Involucrin FERM_C PF09380.10 KII64861.1 - 8.1e-14 51.8 0.5 1.9e-13 50.6 0.0 1.9 2 0 0 2 2 2 1 FERM C-terminal PH-like domain ERM PF00769.19 KII64861.1 - 0.016 15.1 54.8 0.93 9.3 54.2 3.4 1 1 0 1 1 1 0 Ezrin/radixin/moesin family 23S_rRNA_IVP PF05635.11 KII64861.1 - 0.025 14.9 2.5 0.025 14.9 2.5 2.5 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein Cnd1_N PF12922.7 KII64862.1 - 0.0089 15.9 0.1 0.0089 15.9 0.1 4.1 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1, N-term DUF1640 PF07798.11 KII64862.1 - 0.27 11.2 7.9 2.7 8.0 3.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) RIH_assoc PF08454.11 KII64863.1 - 0.44 10.4 0.0 0.44 10.4 0.0 3.5 3 1 0 3 3 3 0 RyR and IP3R Homology associated GST_N_4 PF17172.4 KII64864.1 - 0.0059 17.3 0.0 0.015 16.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C PF00043.25 KII64864.1 - 0.011 15.9 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain RVT_1 PF00078.27 KII64865.1 - 3.4e-27 95.4 0.1 8e-27 94.2 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII64865.1 - 2.1e-06 27.5 11.2 0.0012 18.8 2.0 2.5 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII64865.1 - 1.3e-05 25.4 0.0 8.6e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII64865.1 - 0.00018 22.1 0.0 0.0004 21.0 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII64865.1 - 0.00023 21.7 0.0 0.00048 20.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII64865.1 - 0.00049 19.9 0.1 0.0017 18.1 0.1 1.9 1 1 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 KII64865.1 - 0.0027 17.5 0.3 0.0054 16.5 0.3 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.6 KII64865.1 - 0.0028 17.6 5.9 0.012 15.6 0.5 2.5 1 1 1 2 2 2 1 Zinc knuckle Herpes_UL14 PF03580.14 KII64865.1 - 0.036 14.3 0.6 0.081 13.2 0.0 1.8 2 0 0 2 2 2 0 Herpesvirus UL14-like protein Peptidase_A2B PF12384.8 KII64865.1 - 0.045 13.3 0.0 0.26 10.8 0.0 2.1 1 1 1 2 2 2 0 Ty3 transposon peptidase Zn_Tnp_IS91 PF14319.6 KII64865.1 - 0.049 13.7 3.7 0.18 11.8 3.7 2.0 1 0 0 1 1 1 0 Transposase zinc-binding domain Spuma_A9PTase PF03539.14 KII64865.1 - 0.05 13.7 0.0 0.095 12.8 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) PHD_4 PF16866.5 KII64865.1 - 0.27 11.3 2.7 0.48 10.5 0.7 2.3 1 1 1 2 2 2 0 PHD-finger zf-CCHC_5 PF14787.6 KII64865.1 - 1.1 9.1 9.3 5.8 6.7 1.7 2.5 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-ribbon_3 PF13248.6 KII64865.1 - 3.5 7.2 5.4 10 5.7 0.5 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Dcc1 PF09724.9 KII64866.1 - 1.2e-63 215.5 1.0 1.4e-63 215.2 1.0 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 SNAP PF14938.6 KII64867.1 - 2.7e-24 86.1 11.2 3.2e-24 85.8 11.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII64867.1 - 0.0071 16.6 1.3 0.85 10.0 0.3 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 KII64867.1 - 0.0086 16.7 1.3 4.5 8.1 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat KAsynt_C_assoc PF16197.5 KII64867.1 - 0.011 16.1 0.1 1.6 9.2 0.0 2.2 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension ODC_AZ PF02100.17 KII64868.1 - 0.00037 20.5 0.1 0.00073 19.5 0.1 1.5 1 1 0 1 1 1 1 Ornithine decarboxylase antizyme DDE_1 PF03184.19 KII64869.1 - 8.1e-23 81.0 0.2 9.9e-23 80.7 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Rota_NS6 PF04866.12 KII64870.1 - 0.086 13.1 0.1 0.19 11.9 0.0 1.5 1 1 0 1 1 1 0 Rotavirus non-structural protein 6 Myosin-VI_CBD PF16521.5 KII64870.1 - 0.11 12.5 0.2 0.18 11.8 0.2 1.3 1 0 0 1 1 1 0 Myosin VI cargo binding domain Nup96 PF12110.8 KII64871.1 - 2.8e-39 135.0 0.7 4.9e-39 134.2 0.7 1.4 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 KII64871.1 - 4.2e-39 134.0 0.1 7.8e-39 133.2 0.1 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase HSP90 PF00183.18 KII64872.1 - 1.6e-200 667.4 28.2 2e-200 667.1 28.2 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 KII64872.1 - 3.3e-13 50.1 0.2 1.2e-12 48.3 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KII64872.1 - 1.2e-11 44.6 0.2 1.2e-11 44.6 0.2 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UPF0767 PF15990.5 KII64872.1 - 0.35 11.0 2.9 22 5.3 3.2 2.7 2 0 0 2 2 2 0 UPF0767 family CobT PF06213.12 KII64872.1 - 3.3 7.0 13.4 6.3 6.1 13.4 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DDE_3 PF13358.6 KII64874.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Peptidase_A2B PF12384.8 KII64875.1 - 0.049 13.2 0.0 0.056 13.0 0.0 1.1 1 0 0 1 1 1 0 Ty3 transposon peptidase TBP PF00352.21 KII64876.1 - 6.6e-61 202.3 0.5 4.2e-32 110.0 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 KII64876.1 - 3.4e-08 33.5 0.0 0.012 15.7 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4765 PF15962.5 KII64876.1 - 0.078 10.9 0.0 0.089 10.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4765) Myotub-related PF06602.14 KII64877.1 - 9.8e-15 54.3 1.0 1.4e-14 53.9 1.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Dimer_Tnp_hAT PF05699.14 KII64878.1 - 0.0042 16.9 0.0 0.0071 16.1 0.0 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Sugar_tr PF00083.24 KII64879.1 - 3.9e-32 111.7 16.5 4.4e-32 111.5 16.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII64879.1 - 1.3e-07 30.9 14.8 1.9e-07 30.3 14.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Herpes_LMP1 PF05297.11 KII64879.1 - 0.16 11.1 7.9 0.2 10.8 7.9 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) YibE_F PF07907.11 KII64879.1 - 5 6.6 22.3 0.088 12.3 6.2 2.5 2 1 1 3 3 3 0 YibE/F-like protein Sugar_tr PF00083.24 KII64880.1 - 1.9e-07 30.3 0.1 2.2e-07 30.1 0.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter EGF PF00008.27 KII64881.1 - 0.0021 18.3 8.2 0.0039 17.5 8.2 1.4 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 KII64881.1 - 0.0044 17.4 11.7 0.0081 16.5 11.7 1.4 1 0 0 1 1 1 1 EGF-like domain EGF_MSP1_1 PF12946.7 KII64881.1 - 3.2 7.9 8.5 5.7 7.1 8.5 1.4 1 0 0 1 1 1 0 MSP1 EGF domain 1 EGF PF00008.27 KII64882.1 - 0.0055 17.0 2.6 0.032 14.5 2.6 2.1 1 1 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 KII64882.1 - 1.2 9.6 6.9 6.3 7.3 6.9 2.1 1 1 0 1 1 1 0 EGF-like domain Sugar_tr PF00083.24 KII64884.1 - 1.4e-26 93.4 1.8 1.7e-26 93.1 1.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII64884.1 - 5.8e-12 45.2 1.8 6.7e-12 45.0 1.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DDE_3 PF13358.6 KII64888.1 - 1.4e-18 67.1 0.0 1.6e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII64888.1 - 0.0029 17.3 0.0 0.0036 17.0 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_1 PF01344.25 KII64890.1 - 3.1e-16 58.7 18.9 2.2e-05 23.9 0.3 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KII64890.1 - 2.9e-11 43.2 7.6 0.24 11.4 0.1 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 KII64890.1 - 1.1e-10 41.4 13.4 0.00026 21.2 0.2 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 KII64890.1 - 2.6e-10 40.0 13.6 3.2e-07 30.2 0.4 4.2 4 1 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 KII64890.1 - 7.1e-10 38.9 2.8 0.013 15.8 0.0 4.6 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII64890.1 - 8e-07 28.8 10.6 0.75 9.9 0.1 5.2 5 0 0 5 5 5 3 Kelch motif AdoHcyase_NAD PF00670.21 KII64891.1 - 6.7e-37 127.0 0.3 7.9e-37 126.8 0.3 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 KII64891.1 - 8.1e-08 31.8 0.0 9.2e-08 31.6 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase THF_DHG_CYH_C PF02882.19 KII64891.1 - 0.003 16.9 0.2 0.0053 16.1 0.2 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 KII64891.1 - 0.0031 16.9 0.0 0.0039 16.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 KII64891.1 - 0.035 14.2 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AdoHcyase PF05221.17 KII64892.1 - 5.7e-65 219.4 1.3 5.4e-51 173.5 0.4 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase DUF2889 PF11136.8 KII64892.1 - 0.13 12.6 0.0 3 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2889) Inhibitor_I29 PF08246.12 KII64894.1 - 9e-12 45.2 0.2 1.3e-11 44.7 0.2 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.23 KII64894.1 - 3e-08 34.0 0.2 4.9e-08 33.3 0.2 1.3 1 0 0 1 1 1 1 Papain family cysteine protease CENP-F_leu_zip PF10473.9 KII64896.1 - 5.9e-05 23.1 10.9 0.031 14.3 2.2 2.3 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MscS_porin PF12795.7 KII64896.1 - 0.11 12.0 11.4 4.3 6.8 0.9 2.9 1 1 3 4 4 4 0 Mechanosensitive ion channel porin domain DUF603 PF04645.12 KII64896.1 - 4.2 7.0 8.5 30 4.3 0.7 2.9 1 1 1 2 2 2 0 Protein of unknown function, DUF603 Sugar_tr PF00083.24 KII64899.1 - 4.3e-60 203.9 19.4 5.6e-60 203.5 19.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII64899.1 - 3.6e-16 59.0 30.2 3.6e-16 59.0 30.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Ceramidase PF05875.12 KII64899.1 - 0.0059 16.1 0.4 0.0059 16.1 0.4 2.6 3 0 0 3 3 3 1 Ceramidase RT_RNaseH PF17917.1 KII64900.1 - 1.3e-36 125.1 0.1 4.6e-36 123.3 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII64900.1 - 8.7e-35 118.8 0.0 2e-34 117.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64900.1 - 1.2e-29 103.5 0.0 2.5e-29 102.4 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII64900.1 - 2.5e-24 85.7 0.0 5e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64900.1 - 2.1e-20 72.6 0.4 6.7e-20 71.0 0.4 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII64900.1 - 0.00063 19.9 0.2 0.0036 17.5 0.0 2.4 2 0 0 2 2 2 1 H2C2 zinc finger MLVIN_C PF18697.1 KII64900.1 - 0.0038 17.3 0.0 0.013 15.6 0.0 1.9 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII64900.1 - 0.0061 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII64903.1 - 2.1e-05 24.3 0.0 2.7e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Homeodomain PF00046.29 KII64904.1 - 2.3e-11 43.4 4.0 2.3e-11 43.4 4.0 1.9 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KII64904.1 - 6.4e-10 38.8 0.7 1.2e-09 38.0 0.7 1.4 1 0 0 1 1 1 1 Homeobox KN domain SIX1_SD PF16878.5 KII64904.1 - 8.4e-06 26.3 4.8 8.4e-06 26.3 0.3 2.3 2 1 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homez PF11569.8 KII64904.1 - 0.0028 17.1 0.1 0.0043 16.5 0.1 1.3 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez HTH_26 PF13443.6 KII64904.1 - 0.084 13.3 0.2 0.16 12.4 0.2 1.5 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain SIX1_SD PF16878.5 KII64905.1 - 2.6e-08 34.3 0.3 3.4e-08 34.0 0.3 1.1 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Acetyltransf_2 PF00797.17 KII64905.1 - 0.062 13.1 0.1 0.07 12.9 0.1 1.1 1 0 0 1 1 1 0 N-acetyltransferase Ribonuc_red_lgC PF02867.15 KII64906.1 - 4.1e-187 622.9 0.0 5.2e-187 622.5 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KII64906.1 - 1.6e-20 72.9 0.0 4.4e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 KII64906.1 - 4.4e-12 46.4 0.0 1.5e-11 44.7 0.0 2.0 2 0 0 2 2 2 1 ATP cone domain HIGH_NTase1_ass PF16581.5 KII64906.1 - 0.062 13.3 0.2 0.062 13.3 0.2 1.8 2 0 0 2 2 2 0 Cytidyltransferase-related C-terminal region QIL1 PF15884.5 KII64906.1 - 0.1 13.2 0.2 0.89 10.2 0.0 2.6 2 0 0 2 2 2 0 MICOS complex subunit MIC13, QIL1 MOZ_SAS PF01853.18 KII64908.1 - 8e-78 260.2 0.1 1.4e-77 259.4 0.1 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KII64908.1 - 9e-19 66.8 3.0 3e-18 65.2 3.0 1.9 1 0 0 1 1 1 1 MYST family zinc finger domain PHD PF00628.29 KII64908.1 - 4.6e-07 29.6 24.8 8.6e-06 25.6 3.8 3.1 2 1 1 3 3 3 2 PHD-finger Acetyltransf_7 PF13508.7 KII64908.1 - 0.071 13.6 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain UBA_3 PF09288.10 KII64908.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Serpin PF00079.20 KII64909.1 - 1.2e-46 159.8 2.7 1.3e-46 159.6 2.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF2866 PF11065.8 KII64909.1 - 0.014 15.4 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2866) DpnI_C PF17726.1 KII64909.1 - 0.018 15.1 1.3 0.035 14.2 0.1 2.1 2 0 0 2 2 2 0 Dam-replacing HTH domain Glyco_hydro_38 PF18438.1 KII64909.1 - 0.052 13.6 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal domain 1 SNAP PF14938.6 KII64913.1 - 1.7e-07 31.0 0.7 2.1e-07 30.6 0.7 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII64913.1 - 0.022 14.9 5.0 0.17 12.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat FAT PF02259.23 KII64913.1 - 0.15 11.2 0.1 0.27 10.4 0.1 1.3 1 0 0 1 1 1 0 FAT domain rve PF00665.26 KII64914.1 - 3.6e-24 85.2 0.0 8.1e-24 84.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 KII64914.1 - 7.4e-06 25.8 10.7 2.8e-05 24.0 1.8 2.6 2 0 0 2 2 2 2 Zinc knuckle RVT_1 PF00078.27 KII64914.1 - 9.2e-06 25.3 0.1 1.9e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 KII64914.1 - 0.011 15.5 0.0 0.033 13.9 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain RVP_2 PF08284.11 KII64914.1 - 0.016 15.0 0.2 0.061 13.1 0.1 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease DDE_Tnp_IS240 PF13610.6 KII64914.1 - 0.017 15.3 0.7 0.036 14.3 0.0 1.8 2 0 0 2 2 2 0 DDE domain gag-asp_proteas PF13975.6 KII64914.1 - 0.034 14.7 0.1 0.083 13.5 0.1 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.6 KII64914.1 - 0.18 11.6 7.1 3.1 7.6 0.5 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 KII64914.1 - 2.2 8.2 11.1 5.3 7.0 0.7 2.9 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.6 KII64916.1 - 1.9e-09 37.4 0.0 2.1e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_M1 PF01433.20 KII64919.1 - 2.9e-54 184.0 6.1 4.3e-36 124.5 5.2 2.3 1 1 1 2 2 2 2 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KII64919.1 - 4.8e-41 141.0 0.6 1e-40 139.9 0.6 1.6 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 KII64919.1 - 1.7e-28 100.1 0.0 2.7e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.6 KII64919.1 - 0.0035 17.0 0.4 0.0069 16.1 0.4 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily IstB_IS21_ATP PF08483.11 KII64919.1 - 0.077 12.9 1.3 0.21 11.5 1.3 1.7 1 0 0 1 1 1 0 IstB-like ATP binding N-terminal DUF240 PF03086.14 KII64922.1 - 0.084 12.8 1.6 0.097 12.6 1.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF240) RE_ScaI PF09569.10 KII64922.1 - 0.097 12.4 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 ScaI restriction endonuclease MARVEL PF01284.23 KII64925.1 - 1.7e-05 24.9 5.8 4.7e-05 23.4 5.8 1.8 1 1 0 1 1 1 1 Membrane-associating domain DDE_1 PF03184.19 KII64926.1 - 2.5e-05 24.0 1.5 4.9e-05 23.1 0.0 2.1 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII64926.1 - 5.9e-05 23.0 1.1 0.00011 22.2 1.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain zf-UBR PF02207.20 KII64928.1 - 2.2e-12 47.0 13.5 4.5e-12 45.9 13.5 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-UBR PF02207.20 KII64930.1 - 2.7e-11 43.5 9.3 7.9e-11 42.0 9.3 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) PHF5 PF03660.14 KII64930.1 - 0.12 12.6 3.8 0.37 11.0 3.8 2.0 1 0 0 1 1 1 0 PHF5-like protein Laminin_EGF PF00053.24 KII64930.1 - 4.9 7.4 8.9 0.18 12.0 2.8 1.8 2 0 0 2 2 2 0 Laminin EGF domain Med26 PF08711.11 KII64932.1 - 7.8e-10 38.6 2.3 1.6e-09 37.6 2.3 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Tetraspanin PF00335.20 KII64933.1 - 1.7e-10 41.0 1.8 2.1e-10 40.7 1.8 1.0 1 0 0 1 1 1 1 Tetraspanin family Nuc_H_symport PF03825.16 KII64933.1 - 0.056 12.4 0.4 0.076 12.0 0.4 1.1 1 0 0 1 1 1 0 Nucleoside H+ symporter Lactamase_B PF00753.27 KII64934.1 - 2.7e-12 47.1 0.0 3.2e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KII64934.1 - 7.8e-05 22.3 0.0 9.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 KII64934.1 - 0.047 13.1 0.0 0.063 12.7 0.0 1.1 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain PDEase_II PF02112.15 KII64934.1 - 0.075 12.1 0.1 0.096 11.8 0.1 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II DUF2428 PF10350.9 KII64937.1 - 2.3e-28 99.2 0.6 5.4e-28 98.0 0.6 1.6 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) FCH PF00611.23 KII64937.1 - 0.14 12.4 0.2 0.64 10.3 0.0 2.2 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Actin PF00022.19 KII64940.1 - 1.8e-37 129.0 0.0 2.1e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 Actin Lectin_leg-like PF03388.13 KII64941.1 - 9.4e-56 188.7 0.1 1.3e-55 188.2 0.1 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 KII64941.1 - 2.6e-09 37.4 0.0 5.5e-09 36.3 0.0 1.5 1 1 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 KII64941.1 - 3e-07 30.3 0.1 1.7e-06 27.7 0.1 1.9 1 1 0 1 1 1 1 Legume lectin domain LapA_dom PF06305.11 KII64941.1 - 0.084 12.7 0.3 0.2 11.5 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain JmjN PF02375.17 KII64941.1 - 0.12 12.3 0.1 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 jmjN domain PBP PF01161.20 KII64943.1 - 0.021 15.1 0.1 0.028 14.8 0.1 1.3 1 0 0 1 1 1 0 Phosphatidylethanolamine-binding protein Dehalogenase PF13486.6 KII64946.1 - 0.027 13.9 0.1 0.029 13.8 0.1 1.0 1 0 0 1 1 1 0 Reductive dehalogenase subunit MLVIN_C PF18697.1 KII64947.1 - 0.083 13.0 0.0 0.12 12.5 0.0 1.5 1 1 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVT_1 PF00078.27 KII64948.1 - 2.5e-14 53.3 0.7 9.9e-08 31.8 0.2 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF743 PF05332.11 KII64949.1 - 0.13 12.4 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF743) RVT_1 PF00078.27 KII64959.1 - 0.12 11.8 0.0 0.31 10.5 0.0 1.6 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 KII64960.1 - 1.4e-18 67.3 0.0 1.7e-18 67.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PmrD PF11183.8 KII64961.1 - 0.049 13.8 0.1 0.14 12.3 0.1 1.8 1 1 0 1 1 1 0 Polymyxin resistance protein PmrD RT_RNaseH_2 PF17919.1 KII64963.1 - 3.1e-17 62.4 0.1 3.9e-11 42.9 0.0 2.7 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII64963.1 - 1.7e-16 60.4 0.0 2.7e-14 53.3 0.0 2.6 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII64963.1 - 2.2e-15 56.8 0.4 1.5e-14 54.0 0.1 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII64963.1 - 0.00028 20.9 1.1 0.001 19.1 0.0 2.5 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII64963.1 - 0.0018 18.5 0.0 0.0038 17.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII64964.1 - 1.7e-22 79.7 0.1 2.3e-22 79.3 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII64964.1 - 0.00058 20.1 0.0 0.0009 19.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_ISAZ013 PF07592.11 KII64964.1 - 0.0034 16.4 0.1 0.0037 16.3 0.1 1.2 1 0 0 1 1 1 1 Rhodopirellula transposase DDE domain RdDM_RDM1 PF09187.10 KII64965.1 - 0.065 13.3 0.1 0.074 13.1 0.1 1.1 1 0 0 1 1 1 0 RNA-directed DNA methylation 1 End3 PF12761.7 KII64966.1 - 0.011 16.0 0.8 0.018 15.2 0.8 1.4 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DpnII-MboI PF18742.1 KII64966.1 - 0.024 14.3 0.0 0.055 13.1 0.0 1.6 1 0 0 1 1 1 0 REase_DpnII-MboI APC_N_CC PF16689.5 KII64966.1 - 0.061 13.4 2.4 0.17 12.0 2.4 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain EF_TS PF00889.19 KII64967.1 - 6.9e-06 25.8 0.3 0.00062 19.4 0.0 2.4 1 1 1 2 2 2 2 Elongation factor TS FKBP_N_2 PF18023.1 KII64967.1 - 0.056 13.5 0.2 0.099 12.7 0.2 1.4 1 0 0 1 1 1 0 BDBT FKBP like N-terminal zf-RVT PF13966.6 KII64967.1 - 0.086 13.6 1.8 0.8 10.5 0.1 2.3 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase RT_RNaseH PF17917.1 KII64969.1 - 5.3e-33 113.4 0.0 1.1e-31 109.2 0.0 3.1 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII64969.1 - 3.1e-25 88.1 0.2 4.4e-24 84.4 0.0 2.8 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII64969.1 - 4.4e-18 65.6 0.0 1e-17 64.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII64969.1 - 8.8e-12 45.0 0.9 2.2e-11 43.7 0.9 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII64969.1 - 1.8e-09 37.5 0.0 3.8e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 KII64969.1 - 0.011 15.5 0.0 0.035 13.9 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain Gb3_synth PF04572.12 KII64969.1 - 0.11 12.6 1.5 3.9 7.7 0.0 2.5 1 1 1 2 2 2 0 Alpha 1,4-glycosyltransferase conserved region MFS_1 PF07690.16 KII64970.1 - 8.5e-38 130.2 31.4 1.1e-35 123.2 16.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KII64970.1 - 2.1e-11 43.4 0.5 2.1e-11 43.4 0.5 2.5 2 1 0 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 KII64970.1 - 0.00058 19.3 0.6 0.0014 18.0 0.1 1.9 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DDE_Tnp_IS1595 PF12762.7 KII64972.1 - 1.6e-07 31.4 0.0 2.3e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Amastin PF07344.11 KII64978.1 - 0.21 11.4 14.0 1.1 9.1 5.7 2.5 1 1 1 2 2 2 0 Amastin surface glycoprotein DUF3671 PF12420.8 KII64978.1 - 0.31 11.1 7.3 0.32 11.1 1.9 2.4 1 1 1 2 2 2 0 Protein of unknown function Tsp45I PF06300.12 KII64981.1 - 0.0051 16.4 2.0 0.025 14.1 0.3 2.2 2 0 0 2 2 2 1 Tsp45I type II restriction enzyme Transketolase_N PF00456.21 KII64982.1 - 3.2e-34 118.4 0.0 7.4e-34 117.2 0.0 1.5 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 KII64982.1 - 9.6e-32 110.1 0.1 1.8e-31 109.2 0.1 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KII64982.1 - 1.3e-22 80.0 0.0 9.9e-22 77.1 0.0 2.3 2 0 0 2 2 2 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 KII64982.1 - 7.1e-06 25.4 0.1 0.0042 16.3 0.1 2.6 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 KII64982.1 - 1e-05 24.7 0.0 1.7e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 KII64982.1 - 6.2e-05 22.8 0.1 0.0011 18.8 0.1 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.10 KII64982.1 - 0.02 13.7 0.0 0.037 12.8 0.0 1.3 1 0 0 1 1 1 0 XFP N-terminal domain CAP18_C PF12153.8 KII64982.1 - 0.1 12.4 0.3 0.2 11.6 0.3 1.5 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) Galactosyl_T PF01762.21 KII64985.1 - 6.7e-30 104.4 0.2 9.5e-30 103.9 0.2 1.1 1 0 0 1 1 1 1 Galactosyltransferase Ndc80_HEC PF03801.13 KII64985.1 - 0.12 12.0 0.2 0.26 10.9 0.2 1.6 1 1 0 1 1 1 0 HEC/Ndc80p family Galactosyl_T PF01762.21 KII64988.1 - 6.9e-31 107.6 0.1 1.1e-30 107.0 0.1 1.3 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 KII64989.1 - 2.2e-26 92.9 0.1 3.1e-26 92.4 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 KII64990.1 - 2.2e-26 92.9 0.1 3.1e-26 92.4 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 KII64991.1 - 7.9e-17 61.7 0.3 1e-16 61.4 0.3 1.2 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 KII64992.1 - 4.7e-08 33.1 0.1 5.1e-08 33.0 0.1 1.0 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 KII64993.1 - 7.6e-31 107.5 0.1 1.2e-30 106.8 0.1 1.3 1 0 0 1 1 1 1 Galactosyltransferase MULE PF10551.9 KII64995.1 - 3.6e-17 62.6 0.1 6.6e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 MULE transposase domain Sec63 PF02889.16 KII64997.1 - 2.7e-154 511.8 4.5 2e-82 276.2 0.6 2.6 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 KII64997.1 - 1.6e-46 158.2 0.1 5.5e-30 104.4 0.1 2.9 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 KII64997.1 - 2.1e-36 124.5 0.4 1.2e-35 122.0 0.4 2.5 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 KII64997.1 - 6.9e-21 75.0 0.0 1.8e-13 50.9 0.0 2.9 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KII64997.1 - 4.4e-12 46.3 0.9 3.7e-08 33.7 0.0 4.7 4 2 0 4 4 3 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 KII64997.1 - 1.1e-05 25.2 0.0 0.0088 15.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KII64997.1 - 1.6e-05 25.2 0.0 0.092 13.0 0.1 3.3 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KII64997.1 - 0.00032 21.0 0.0 0.21 11.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 KII64997.1 - 0.00038 19.6 0.0 0.19 10.7 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_11 PF13086.6 KII64997.1 - 0.00048 20.0 2.1 0.073 12.8 0.0 3.5 3 1 1 4 4 4 1 AAA domain AAA_7 PF12775.7 KII64997.1 - 0.0046 16.5 0.0 0.68 9.4 0.0 2.9 2 0 0 2 2 2 1 P-loop containing dynein motor region PhoH PF02562.16 KII64997.1 - 0.021 14.3 0.0 4.5 6.7 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein CobA_CobO_BtuR PF02572.15 KII64997.1 - 0.15 12.3 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP adh_short PF00106.25 KII64998.1 - 7.5e-29 100.6 0.0 9.6e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII64998.1 - 1.8e-15 57.2 0.0 2.1e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII64998.1 - 1.4e-07 31.6 0.0 2.3e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KII64998.1 - 1.2e-06 28.2 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 KII64998.1 - 0.00037 20.4 0.0 0.00061 19.7 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 KII64998.1 - 0.0016 17.8 0.0 0.0028 17.1 0.0 1.4 1 0 0 1 1 1 1 ThiF family TrkA_N PF02254.18 KII64998.1 - 0.0038 17.5 0.0 0.0068 16.6 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain DUF4304 PF14137.6 KII64998.1 - 0.024 14.8 0.0 0.51 10.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4304) Polysacc_synt_2 PF02719.15 KII64998.1 - 0.028 13.6 0.0 0.044 12.9 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ApbA PF02558.16 KII64998.1 - 0.029 14.0 0.0 0.039 13.6 0.0 1.4 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GDP_Man_Dehyd PF16363.5 KII64998.1 - 0.031 13.7 0.3 0.23 10.8 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DUF2325 PF10087.9 KII64998.1 - 0.039 14.1 0.9 0.15 12.2 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) DUF5099 PF17025.5 KII64998.1 - 0.04 14.3 0.4 0.1 13.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5099) DapB_N PF01113.20 KII64998.1 - 0.047 13.8 0.0 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 KII64998.1 - 0.066 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 KII64998.1 - 0.15 12.5 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding ExbD PF02472.16 KII64998.1 - 1.7 8.9 7.5 7.3 6.8 0.3 2.7 3 1 0 3 3 2 0 Biopolymer transport protein ExbD/TolR HEPN_DZIP3 PF18738.1 KII64999.1 - 0.15 11.8 0.5 5.7 6.7 0.1 2.1 1 1 0 2 2 2 0 DZIP3/ hRUL138-like HEPN RVT_1 PF00078.27 KII65000.1 - 5.3e-35 120.9 0.0 9.3e-35 120.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII65000.1 - 5.3e-33 113.0 0.1 2.1e-32 111.1 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65000.1 - 1.1e-29 102.8 0.0 8.4e-29 99.9 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII65000.1 - 3.4e-22 78.3 0.4 2.3e-21 75.7 0.3 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII65000.1 - 1.5e-18 67.1 0.0 3e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain gag-asp_proteas PF13975.6 KII65000.1 - 1.5e-06 28.7 0.0 3.5e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII65000.1 - 4.8e-05 23.2 2.5 4.8e-05 23.2 2.5 2.4 2 0 0 2 2 2 1 Zinc knuckle Asp_protease_2 PF13650.6 KII65000.1 - 0.00043 20.9 0.0 0.0015 19.1 0.0 2.0 1 0 0 1 1 1 1 Aspartyl protease MLVIN_C PF18697.1 KII65000.1 - 0.0013 18.8 0.0 0.0039 17.3 0.0 1.8 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain zf-H2C2 PF09337.10 KII65000.1 - 0.013 15.7 0.0 0.039 14.2 0.0 1.9 1 0 0 1 1 1 0 H2C2 zinc finger REC1 PF18501.1 KII65000.1 - 0.023 14.6 2.5 0.069 13.0 0.4 2.6 1 1 1 2 2 2 0 Alpha helical recognition lobe domain RVP PF00077.20 KII65000.1 - 0.033 14.5 0.0 0.08 13.3 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_6 PF15288.6 KII65000.1 - 0.042 13.7 3.4 0.16 11.9 3.4 2.0 1 0 0 1 1 1 0 Zinc knuckle Asp_protease PF09668.10 KII65000.1 - 0.05 13.4 0.0 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Aspartyl protease zf-CCHC_4 PF14392.6 KII65000.1 - 0.069 12.9 1.4 0.24 11.2 1.4 2.0 1 0 0 1 1 1 0 Zinc knuckle MATalpha_HMGbox PF04769.12 KII65000.1 - 0.14 11.4 0.6 0.5 9.6 0.0 2.0 2 0 0 2 2 2 0 Mating-type protein MAT alpha 1 HMG-box zf-3CxxC PF13695.6 KII65000.1 - 0.4 11.2 2.0 6 7.4 0.0 3.2 3 1 0 3 3 3 0 Zinc-binding domain Ldl_recept_a PF00057.18 KII65002.1 - 2.1e-28 98.2 75.2 2.8e-10 40.2 14.4 5.2 6 0 0 6 6 6 4 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII65004.1 - 4.5e-08 33.6 0.3 6.1e-08 33.2 0.3 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal DUF5431 PF17496.2 KII65005.1 - 0.19 11.9 0.3 4.6 7.5 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5431) Ldl_recept_a PF00057.18 KII65007.1 - 1.7e-22 79.3 50.2 3.9e-11 43.0 13.2 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 KII65007.1 - 0.0049 16.7 26.4 0.14 11.9 16.3 2.7 1 1 1 2 2 2 2 Glucosidase II beta subunit-like Isochorismatase PF00857.20 KII65011.1 - 9.7e-25 87.7 0.3 4.9e-24 85.5 0.3 1.8 1 1 0 1 1 1 1 Isochorismatase family Phage_int_SAM_6 PF18644.1 KII65013.1 - 0.0065 16.5 3.4 0.06 13.4 0.1 2.9 2 1 0 2 2 2 2 Phage integrase SAM-like domain DiSB-ORF2_chro PF16506.5 KII65019.1 - 0.094 12.7 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Putative virion glycoprotein of insect viruses PFK PF00365.20 KII65020.1 - 2e-59 201.3 0.4 2.5e-59 201.0 0.4 1.1 1 0 0 1 1 1 1 Phosphofructokinase DAGK_cat PF00781.24 KII65020.1 - 0.011 15.4 0.0 0.12 12.0 0.0 2.5 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain PfkB PF00294.24 KII65021.1 - 9.5e-42 143.3 0.2 1.5e-40 139.4 0.2 2.0 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 KII65021.1 - 1.1e-17 64.3 0.0 2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase HTH_DeoR PF08220.12 KII65021.1 - 2.8e-12 46.2 0.1 5e-12 45.4 0.1 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain DUF2250 PF10007.9 KII65021.1 - 0.0004 20.4 0.0 0.00096 19.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_11 PF08279.12 KII65021.1 - 0.0071 16.3 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 HTH domain Carb_kinase PF01256.17 KII65021.1 - 0.019 14.4 0.1 0.033 13.7 0.1 1.2 1 0 0 1 1 1 0 Carbohydrate kinase GntR PF00392.21 KII65021.1 - 0.028 14.1 0.0 0.07 12.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family FeoC PF09012.10 KII65021.1 - 0.049 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator DUF5525 PF17663.1 KII65021.1 - 0.17 10.0 0.0 0.22 9.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5525) DHDPS PF00701.22 KII65022.1 - 1.2e-23 83.2 0.0 1.4e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family HTH_38 PF13936.6 KII65022.1 - 0.21 11.4 0.2 23 4.9 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain DUF386 PF04074.12 KII65023.1 - 2e-37 128.4 0.0 2.2e-37 128.2 0.0 1.0 1 0 0 1 1 1 1 YhcH/YjgK/YiaL Porin_8 PF16966.5 KII65024.1 - 8.2e-173 574.5 20.5 9.3e-173 574.3 20.5 1.0 1 0 0 1 1 1 1 Porin-like glycoporin RafY Peripla_BP_3 PF13377.6 KII65025.1 - 9.1e-20 71.6 0.0 1.4e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 KII65025.1 - 0.003 17.0 0.1 0.0037 16.7 0.1 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family RRM_1 PF00076.22 KII65026.1 - 2.2e-16 59.4 0.1 3.6e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 KII65026.1 - 1.7e-06 28.5 3.4 3e-06 27.7 1.9 2.0 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Albumin_I_a PF16720.5 KII65028.1 - 0.34 10.8 4.2 2.6 8.0 0.1 2.4 2 0 0 2 2 2 0 Albumin I chain a zf-CCHC PF00098.23 KII65029.1 - 6.1e-05 22.9 0.9 0.0001 22.2 0.9 1.3 1 0 0 1 1 1 1 Zinc knuckle Cnn_1N PF07989.11 KII65029.1 - 0.032 14.4 0.7 0.34 11.1 0.1 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 ATPase_2 PF01637.18 KII65029.1 - 0.071 13.0 0.2 0.1 12.5 0.2 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea zf-C2H2_10 PF16588.5 KII65029.1 - 0.19 11.5 0.7 0.42 10.4 0.7 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger zf-like PF04071.12 KII65030.1 - 0.043 13.7 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Cysteine-rich small domain T3SchapCesA PF11439.8 KII65030.1 - 0.13 12.5 1.0 4 7.7 0.0 2.6 2 1 0 2 2 2 0 Type III secretion system filament chaperone CesA SIP1 PF04938.12 KII65033.1 - 0.12 12.0 0.1 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) CH PF00307.31 KII65035.1 - 2.7e-67 223.8 5.1 8.1e-19 67.8 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KII65035.1 - 1.1e-12 47.6 0.7 5.4e-05 23.0 0.0 3.3 4 0 0 4 4 4 2 CAMSAP CH domain CH_2 PF06294.11 KII65035.1 - 0.047 13.8 0.1 0.31 11.2 0.0 2.4 2 0 0 2 2 2 0 CH-like domain in sperm protein Myb_DNA-bind_7 PF15963.5 KII65037.1 - 2.1e-19 69.2 0.2 2.6e-19 68.9 0.2 1.1 1 0 0 1 1 1 1 Myb DNA-binding like HA2 PF04408.23 KII65040.1 - 1e-22 80.4 0.3 2.2e-21 76.2 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KII65040.1 - 2.1e-21 76.0 0.2 6e-21 74.6 0.2 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KII65040.1 - 1.8e-14 54.0 0.0 5.9e-14 52.3 0.0 1.9 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KII65040.1 - 0.00012 21.9 0.1 0.00068 19.5 0.1 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 KII65040.1 - 0.00063 19.5 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KII65040.1 - 0.0011 19.3 0.0 0.0036 17.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 KII65040.1 - 0.0069 15.5 0.0 0.015 14.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 KII65040.1 - 0.0075 15.9 0.0 0.029 14.0 0.0 2.0 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 KII65040.1 - 0.0079 16.5 0.0 0.017 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 KII65040.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 KII65040.1 - 0.029 14.4 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain PhoH PF02562.16 KII65040.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.15 KII65040.1 - 0.11 12.5 0.0 4.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ATPase PF06745.13 KII65040.1 - 0.14 11.5 0.1 0.38 10.1 0.1 1.7 1 1 0 1 1 1 0 KaiC SecA_DEAD PF07517.14 KII65040.1 - 0.14 11.4 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain TPR_2 PF07719.17 KII65041.1 - 1.3e-49 162.4 16.4 9.5e-06 25.4 0.1 14.6 15 0 0 15 15 14 9 Tetratricopeptide repeat TPR_1 PF00515.28 KII65041.1 - 1.4e-43 145.0 35.2 4.4e-07 29.4 0.0 14.9 16 1 0 16 16 16 8 Tetratricopeptide repeat TPR_19 PF14559.6 KII65041.1 - 1.4e-37 128.0 0.0 0.00019 21.9 0.0 10.1 6 3 2 9 9 9 7 Tetratricopeptide repeat TPR_12 PF13424.6 KII65041.1 - 2.6e-36 123.7 2.9 4.7e-09 36.4 0.0 10.9 7 3 4 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 KII65041.1 - 3.4e-35 117.3 20.9 0.00011 22.1 0.5 12.9 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_14 PF13428.6 KII65041.1 - 1.9e-31 106.1 0.0 0.00016 22.2 0.0 13.0 9 5 6 15 15 13 7 Tetratricopeptide repeat TPR_16 PF13432.6 KII65041.1 - 2.4e-29 101.7 0.0 5.6e-08 33.3 0.0 10.1 9 3 1 11 11 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 KII65041.1 - 1.9e-22 77.6 4.4 0.028 14.4 0.0 10.6 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_6 PF13174.6 KII65041.1 - 5.7e-22 76.8 12.3 0.00056 20.4 0.1 12.2 15 0 0 15 15 12 4 Tetratricopeptide repeat TPR_11 PF13414.6 KII65041.1 - 6.4e-19 67.4 20.1 0.003 17.2 0.0 11.8 10 2 2 12 12 11 6 TPR repeat TPR_17 PF13431.6 KII65041.1 - 1.9e-17 62.3 26.4 0.3 11.6 0.0 15.7 17 0 0 17 17 16 3 Tetratricopeptide repeat TPR_10 PF13374.6 KII65041.1 - 1.7e-15 56.3 0.0 0.0056 16.5 0.0 7.7 8 0 0 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KII65041.1 - 1.1e-12 48.0 14.7 0.011 15.9 0.0 6.9 5 1 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 KII65041.1 - 5.7e-11 42.0 0.1 5.7e-11 42.0 0.1 3.5 2 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 KII65041.1 - 3.5e-08 33.5 0.0 0.3 11.3 0.0 5.4 4 1 0 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KII65041.1 - 0.00022 21.2 6.9 0.36 10.9 0.0 5.3 5 0 0 5 5 4 2 Fis1 C-terminal tetratricopeptide repeat RPN7 PF10602.9 KII65041.1 - 0.087 12.5 12.0 0.7 9.6 0.4 5.1 5 1 1 6 6 5 0 26S proteasome subunit RPN7 GAGA_bind PF06217.12 KII65041.1 - 0.77 10.0 6.7 1.6 8.9 6.7 1.5 1 0 0 1 1 1 0 GAGA binding protein-like family Peptidase_M24 PF00557.24 KII65044.1 - 0.026 14.2 0.1 0.035 13.8 0.1 1.2 1 0 0 1 1 1 0 Metallopeptidase family M24 DUF1387 PF07139.11 KII65044.1 - 0.059 13.1 0.6 0.068 12.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Peptidase_M24 PF00557.24 KII65045.1 - 7.6e-31 107.4 0.0 9.3e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Fungal_TACC PF12709.7 KII65047.1 - 0.004 17.6 1.8 0.004 17.6 1.8 2.0 1 1 1 2 2 2 1 Fungal Transforming acidic coiled-coil (TACC) proteins Uso1_p115_C PF04871.13 KII65047.1 - 0.14 12.5 5.1 0.21 12.0 5.1 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3128 PF11326.8 KII65048.1 - 0.057 13.8 0.9 0.096 13.1 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) AAA PF00004.29 KII65049.1 - 1.6e-52 177.4 0.2 9e-39 132.9 0.1 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KII65049.1 - 4.9e-11 42.3 0.0 1e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KII65049.1 - 5.7e-10 39.6 1.8 0.0046 17.2 0.0 4.1 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 KII65049.1 - 1.2e-07 31.8 0.4 0.0021 18.1 0.1 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KII65049.1 - 1.4e-07 31.8 0.0 6.7e-06 26.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ATPase PF06745.13 KII65049.1 - 5.4e-07 29.2 0.3 0.012 15.0 0.1 2.6 2 0 0 2 2 2 2 KaiC AAA_16 PF13191.6 KII65049.1 - 7.1e-07 29.8 0.1 0.06 13.7 0.1 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 KII65049.1 - 2.2e-06 27.3 0.0 0.01 15.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region TIP49 PF06068.13 KII65049.1 - 7.6e-06 25.4 0.1 0.09 12.0 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 KII65049.1 - 1.4e-05 25.7 0.0 0.026 15.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 KII65049.1 - 2e-05 24.1 0.6 0.0054 16.1 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KII65049.1 - 3.1e-05 23.8 0.0 0.17 11.6 0.1 2.7 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KII65049.1 - 9e-05 22.3 0.1 0.094 12.4 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein TsaE PF02367.17 KII65049.1 - 9.6e-05 22.4 0.0 0.47 10.5 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE CDC48_N PF02359.18 KII65049.1 - 0.00011 22.3 0.0 0.0017 18.5 0.0 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain RNA_helicase PF00910.22 KII65049.1 - 0.00019 21.7 0.1 0.14 12.6 0.0 2.9 3 0 0 3 3 2 1 RNA helicase Sigma54_activat PF00158.26 KII65049.1 - 0.00021 21.1 0.7 0.72 9.5 0.0 2.7 3 0 0 3 3 2 2 Sigma-54 interaction domain AAA_33 PF13671.6 KII65049.1 - 0.00058 20.0 0.0 0.34 11.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KII65049.1 - 0.00061 19.6 0.1 0.045 13.5 0.0 2.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 KII65049.1 - 0.00063 19.8 0.0 0.42 10.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 KII65049.1 - 0.00069 19.3 1.4 0.89 9.1 0.2 3.0 4 0 0 4 4 2 2 AAA domain NACHT PF05729.12 KII65049.1 - 0.0011 19.0 1.7 3.6 7.5 0.0 3.6 4 0 0 4 4 4 1 NACHT domain AAA_3 PF07726.11 KII65049.1 - 0.0013 18.6 0.0 0.015 15.1 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 KII65049.1 - 0.0016 17.9 0.1 1.6 8.2 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein ABC_tran PF00005.27 KII65049.1 - 0.0082 16.7 1.0 0.14 12.7 0.1 2.4 2 0 0 2 2 2 1 ABC transporter CDC48_2 PF02933.17 KII65049.1 - 0.01 15.6 0.5 0.029 14.1 0.0 2.0 2 0 0 2 2 1 0 Cell division protein 48 (CDC48), domain 2 Zeta_toxin PF06414.12 KII65049.1 - 0.012 14.9 0.1 1.2 8.4 0.0 2.6 3 0 0 3 3 3 0 Zeta toxin Rad51 PF08423.11 KII65049.1 - 0.022 14.0 0.1 0.051 12.8 0.1 1.6 1 0 0 1 1 1 0 Rad51 IPT PF01745.16 KII65049.1 - 0.025 14.0 0.0 0.69 9.3 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Parvo_NS1 PF01057.17 KII65049.1 - 0.026 13.6 0.0 2.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 KII65049.1 - 0.028 14.7 0.0 3.5 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KII65049.1 - 0.039 13.7 0.0 0.4 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Thioredoxin_9 PF14595.6 KII65049.1 - 0.067 13.0 0.2 0.29 10.9 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin AAA_19 PF13245.6 KII65049.1 - 0.19 12.0 2.4 1.3 9.3 0.1 2.8 3 0 0 3 3 2 0 AAA domain ATPase_2 PF01637.18 KII65049.1 - 2.1 8.2 4.2 9 6.1 0.1 3.4 4 1 1 5 5 4 0 ATPase domain predominantly from Archaea RhoGAP PF00620.27 KII65050.1 - 7.2e-20 71.4 0.4 5.7e-09 36.0 0.2 2.3 1 1 1 2 2 2 2 RhoGAP domain NUC173 PF08161.12 KII65052.1 - 8.2e-05 22.4 0.5 0.00046 19.9 0.2 2.4 3 0 0 3 3 3 1 NUC173 domain BCIP PF13862.6 KII65054.1 - 0.00023 21.0 2.3 0.0055 16.5 0.0 2.7 1 1 1 2 2 2 1 p21-C-terminal region-binding protein Myb_DNA-bind_7 PF15963.5 KII65057.1 - 0.00027 20.8 0.8 0.00074 19.4 0.8 1.8 1 1 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 KII65057.1 - 0.0017 18.5 0.0 0.0033 17.6 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain FAM150 PF15129.6 KII65058.1 - 0.18 12.0 3.0 0.15 12.2 1.0 1.7 2 0 0 2 2 2 0 FAM150 family 2TM PF13239.6 KII65058.1 - 0.72 10.2 5.3 0.41 11.0 0.2 2.2 2 0 0 2 2 2 0 2TM domain PAP2 PF01569.21 KII65059.1 - 5e-15 55.5 2.7 5.8e-15 55.3 2.7 1.0 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 KII65059.1 - 0.0002 21.5 0.7 0.081 13.1 0.1 2.2 1 1 1 2 2 2 2 Divergent PAP2 family DUF1576 PF07613.11 KII65059.1 - 0.0043 16.6 3.3 0.0056 16.2 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1576) RRM_1 PF00076.22 KII65060.1 - 0.059 13.2 2.1 2.7 7.9 0.0 3.3 3 2 1 4 4 4 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rsm22 PF09243.10 KII65063.1 - 8.2e-05 22.0 0.0 0.00015 21.1 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 PRP8_domainIV PF12134.8 KII65063.1 - 0.025 14.2 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 PRP8 domain IV core Ribosomal_S8 PF00410.19 KII65064.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S8 Tropomyosin PF00261.20 KII65065.1 - 0.00022 20.7 36.9 0.00088 18.7 36.9 2.2 1 1 0 1 1 1 1 Tropomyosin Lebercilin PF15619.6 KII65065.1 - 0.00034 20.3 16.5 0.00034 20.3 16.5 2.4 1 1 1 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease DUF4472 PF14739.6 KII65065.1 - 0.017 15.9 28.0 0.087 13.6 3.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) Speriolin_C PF15059.6 KII65065.1 - 0.023 14.8 1.4 0.023 14.8 1.4 2.5 2 1 0 2 2 2 0 Speriolin C-terminus UDPGT PF00201.18 KII65065.1 - 0.064 12.0 2.0 0.066 12.0 1.3 1.4 1 1 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase GAS PF13851.6 KII65065.1 - 0.16 11.3 35.4 0.27 10.6 9.3 2.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ADIP PF11559.8 KII65065.1 - 0.18 11.9 37.3 0.17 12.0 11.6 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.7 KII65065.1 - 0.31 11.2 34.9 5.9 7.0 20.4 2.4 1 1 1 2 2 2 0 Tropomyosin like Spc7 PF08317.11 KII65065.1 - 0.32 9.9 38.2 0.11 11.3 18.1 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein AIP3 PF03915.13 KII65065.1 - 0.38 9.8 28.8 0.47 9.5 28.8 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 ATG16 PF08614.11 KII65065.1 - 0.59 10.3 37.3 0.83 9.9 20.7 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SMODS PF18144.1 KII65065.1 - 0.59 10.3 9.5 0.77 9.9 1.3 3.1 1 1 0 3 3 3 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain DUF4522 PF15022.6 KII65065.1 - 0.77 10.0 10.4 0.04 14.2 2.7 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF4522) DUF4411 PF14367.6 KII65065.1 - 0.89 9.4 10.9 2.7 7.9 1.7 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4411) EzrA PF06160.12 KII65065.1 - 1.4 7.1 32.9 0.24 9.6 10.1 2.8 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Osmo_CC PF08946.10 KII65065.1 - 1.4 9.2 11.9 1.1 9.5 0.1 4.0 3 0 0 3 3 3 0 Osmosensory transporter coiled coil BST2 PF16716.5 KII65065.1 - 1.6 9.4 32.8 0.8 10.3 8.1 4.1 1 1 2 4 4 4 0 Bone marrow stromal antigen 2 DUF4407 PF14362.6 KII65065.1 - 3.1 7.0 26.8 42 3.3 19.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) CALCOCO1 PF07888.11 KII65065.1 - 3.7 6.3 35.9 1.3 7.8 23.2 2.2 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like FUSC PF04632.12 KII65065.1 - 4.1 5.8 9.2 5.2 5.5 9.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF745 PF05335.13 KII65065.1 - 4.4 7.0 22.8 2.3 7.9 5.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF745) DUF724 PF05266.14 KII65065.1 - 4.7 7.0 32.4 0.072 12.9 8.9 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF724) APG17 PF04108.12 KII65065.1 - 4.9 6.1 28.9 8.6 5.4 6.7 2.2 1 1 1 2 2 2 0 Autophagy protein Apg17 Fez1 PF06818.15 KII65065.1 - 6.5 7.2 32.5 18 5.7 24.4 2.8 1 1 1 2 2 2 0 Fez1 TMF_TATA_bd PF12325.8 KII65065.1 - 6.8 6.9 36.2 2 8.7 5.0 4.0 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding DHR10 PF18595.1 KII65065.1 - 7.2 6.7 39.9 4.1 7.5 14.3 4.2 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain DUF3450 PF11932.8 KII65065.1 - 9.2 5.5 34.4 0.48 9.7 9.6 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Serinc PF03348.15 KII65068.1 - 4e-115 385.2 25.6 4.8e-115 384.9 25.6 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) Pkinase PF00069.25 KII65069.1 - 2.6e-43 148.3 0.0 3.1e-43 148.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII65069.1 - 3.8e-25 88.7 0.0 4.5e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII65069.1 - 0.001 18.5 0.0 0.0015 17.9 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KII65069.1 - 0.0068 15.2 0.0 0.01 14.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase GARS_A PF01071.19 KII65069.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AA_permease_2 PF13520.6 KII65074.1 - 2.7e-42 145.1 60.3 3.5e-42 144.7 60.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII65074.1 - 3.4e-23 82.0 54.3 4.4e-23 81.6 54.3 1.2 1 0 0 1 1 1 1 Amino acid permease Nop PF01798.18 KII65075.1 - 4.6e-09 36.1 0.0 5.3e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin rve PF00665.26 KII65076.1 - 2.1e-20 73.1 0.0 3.6e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65076.1 - 1.9e-06 27.6 0.0 6.3e-06 25.9 0.0 2.0 1 1 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65076.1 - 8.5e-05 22.6 0.2 0.00026 21.0 0.2 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain Agenet PF05641.12 KII65076.1 - 0.0014 19.1 0.1 0.0035 17.8 0.1 1.7 1 0 0 1 1 1 1 Agenet domain Peptidase_S8 PF00082.22 KII65078.1 - 5.9e-38 130.8 0.3 9e-38 130.2 0.3 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KII65078.1 - 4.6e-23 81.0 0.1 1e-22 80.0 0.1 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 KII65079.1 - 5.2e-11 43.2 0.3 6.6e-11 42.8 0.3 1.1 1 0 0 1 1 1 1 Peptidase S8 pro-domain CNOT1_CAF1_bind PF16415.5 KII65079.1 - 0.032 13.6 0.6 0.045 13.1 0.6 1.3 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Antimicrobial_5 PF08026.11 KII65080.1 - 1.6 8.9 6.4 2.6 8.2 6.4 1.3 1 0 0 1 1 1 0 Bee antimicrobial peptide RhoGAP PF00620.27 KII65081.1 - 3.4e-05 23.7 0.0 0.00013 21.8 0.0 2.0 1 1 1 2 2 2 1 RhoGAP domain Fumble PF03630.14 KII65082.1 - 1.9e-110 369.1 3.1 2.7e-110 368.6 3.1 1.2 1 0 0 1 1 1 1 Fumble DUF89 PF01937.19 KII65082.1 - 1.6e-15 57.0 0.0 1.4e-13 50.5 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function DUF89 HGTP_anticodon PF03129.20 KII65083.1 - 0.1 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Anticodon binding domain MRP-S23 PF10484.9 KII65083.1 - 1.1 9.6 3.8 13 6.0 0.2 2.2 1 1 1 2 2 2 0 Mitochondrial ribosomal protein S23 CDC50 PF03381.15 KII65084.1 - 1.8e-51 175.3 1.0 1.8e-51 175.3 1.0 1.3 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CUB_2 PF02408.20 KII65084.1 - 0.0054 16.5 0.3 0.012 15.4 0.3 1.5 1 0 0 1 1 1 1 CUB-like domain DUF4764 PF15961.5 KII65085.1 - 0.00022 20.1 0.2 0.00022 20.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) zf-C2H2_4 PF13894.6 KII65085.1 - 0.00032 21.3 0.8 0.00082 20.0 0.8 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 KII65085.1 - 0.00033 20.9 2.0 0.00079 19.8 2.0 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KII65085.1 - 0.00042 20.5 0.2 0.001 19.3 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 KII65085.1 - 0.019 15.4 5.7 0.099 13.1 1.2 2.7 2 0 0 2 2 2 0 Zinc-finger double domain zf-met PF12874.7 KII65085.1 - 0.023 15.1 0.5 0.063 13.7 0.5 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KII65085.1 - 0.026 14.5 0.5 0.059 13.4 0.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KII65086.1 - 0.00032 21.0 0.2 0.00051 20.4 0.2 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 KII65086.1 - 0.0051 17.1 0.1 0.008 16.5 0.1 1.4 1 1 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 KII65086.1 - 0.011 16.5 0.2 0.02 15.7 0.2 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KII65086.1 - 0.012 15.8 1.5 0.03 14.5 1.5 1.8 1 1 0 1 1 1 0 Aberrant zinc-finger DDE_3 PF13358.6 KII65087.1 - 1.7e-06 27.9 0.4 2.5e-06 27.3 0.3 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease FLYWCH PF04500.16 KII65088.1 - 3.7e-07 30.2 5.4 5.1e-07 29.7 5.4 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain FLYWCH PF04500.16 KII65089.1 - 3.7e-07 30.2 5.4 5.1e-07 29.7 5.4 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain RVP PF00077.20 KII65090.1 - 0.0038 17.5 0.9 0.2 12.0 0.1 2.4 1 1 1 2 2 2 2 Retroviral aspartyl protease Exo70 PF03081.15 KII65091.1 - 4.3e-09 35.9 14.5 9.5e-09 34.8 14.5 1.5 1 0 0 1 1 1 1 Exo70 exocyst complex subunit GerPC PF10737.9 KII65091.1 - 0.034 14.2 1.3 0.072 13.1 0.1 2.1 2 0 0 2 2 2 0 Spore germination protein GerPC Membr_traf_MHD PF10540.9 KII65091.1 - 0.75 10.0 4.3 0.3 11.2 0.4 2.3 3 0 0 3 3 3 0 Munc13 (mammalian uncoordinated) homology domain PAS_9 PF13426.7 KII65092.1 - 0.00042 20.5 0.1 0.00072 19.8 0.1 1.4 1 1 0 1 1 1 1 PAS domain PAS PF00989.25 KII65092.1 - 0.0013 18.7 0.0 0.0043 17.0 0.0 1.8 1 1 0 1 1 1 1 PAS fold Yqai PF09466.10 KII65094.1 - 0.11 12.8 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 Hypothetical protein Yqai DDE_3 PF13358.6 KII65095.1 - 2e-10 40.6 0.1 2.6e-10 40.3 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII65097.1 - 0.0091 15.8 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RVT_1 PF00078.27 KII65098.1 - 5.5e-09 35.9 0.7 6.1e-08 32.5 0.2 2.4 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII65098.1 - 0.0083 16.1 0.2 0.036 14.1 0.1 2.1 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 KII65099.1 - 0.026 14.3 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain RRM_1 PF00076.22 KII65100.1 - 1.5e-32 111.2 0.0 1.2e-19 69.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII65100.1 - 0.0016 18.5 0.0 0.0039 17.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 KII65100.1 - 0.0029 17.4 0.0 0.0073 16.1 0.0 1.7 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_3 PF08777.11 KII65100.1 - 0.0085 16.1 0.3 0.033 14.2 0.1 1.9 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 KII65100.1 - 0.045 13.8 0.0 0.25 11.3 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF5102 PF17104.5 KII65100.1 - 0.39 10.7 0.0 0.39 10.7 0.0 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF5102) DDE_Tnp_IS1595 PF12762.7 KII65103.1 - 3.5e-13 49.8 0.0 4.3e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.14 KII65103.1 - 0.077 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Transposase IS66 family NuA4 PF09340.10 KII65104.1 - 0.94 9.4 5.7 1.9 8.5 5.7 1.5 1 1 0 1 1 1 0 Histone acetyltransferase subunit NuA4 Glyco_hydro_20 PF00728.22 KII65105.1 - 0.047 13.1 3.7 0.078 12.3 3.7 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain LCAT PF02450.15 KII65106.1 - 3.7e-45 154.8 0.4 1.3e-34 120.1 0.1 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 KII65106.1 - 4.1e-08 32.8 0.0 5.3e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KII65106.1 - 0.00031 21.4 0.0 0.00036 21.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 KII65106.1 - 0.00065 19.5 0.0 0.00091 19.0 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.11 KII65106.1 - 0.0093 15.3 0.2 0.034 13.5 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Ku_PK_bind PF08785.11 KII65107.1 - 0.083 13.0 0.2 0.13 12.4 0.2 1.3 1 0 0 1 1 1 0 Ku C terminal domain like UQ_con PF00179.26 KII65108.1 - 7.1e-05 22.5 0.0 0.0001 22.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TPR_2 PF07719.17 KII65109.1 - 0.0021 18.0 0.1 0.39 11.0 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KII65109.1 - 0.004 17.4 0.1 0.008 16.4 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII65109.1 - 0.072 13.3 0.2 22 5.6 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat UQ_con PF00179.26 KII65110.1 - 2.9e-45 153.4 0.2 3.3e-45 153.2 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KII65110.1 - 0.0002 21.2 0.1 0.00041 20.2 0.1 1.6 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 KII65110.1 - 0.00051 19.7 0.0 0.00074 19.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KII65110.1 - 0.12 12.7 1.0 0.23 11.8 1.0 1.8 1 1 0 1 1 1 0 RWD domain PhnG PF06754.12 KII65111.1 - 0.19 11.7 0.0 0.25 11.3 0.0 1.1 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnG Arm-DNA-bind_5 PF17293.2 KII65113.1 - 0.14 12.6 2.1 0.2 12.1 0.3 2.1 1 1 1 2 2 2 0 Arm DNA-binding domain FAE1_CUT1_RppA PF08392.12 KII65114.1 - 0.05 12.9 0.0 0.082 12.2 0.0 1.3 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein Ldl_recept_a PF00057.18 KII65115.1 - 5.6e-19 68.1 35.4 1.8e-09 37.7 14.4 2.1 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Orf78 PF06024.12 KII65116.1 - 0.018 15.3 0.3 0.036 14.4 0.1 1.6 2 0 0 2 2 2 0 Orf78 (ac78) Synaptobrevin PF00957.21 KII65116.1 - 0.4 10.5 4.0 0.83 9.5 4.0 1.5 1 0 0 1 1 1 0 Synaptobrevin Pox_A21 PF05323.12 KII65116.1 - 3.3 8.3 7.3 7 7.3 0.0 3.0 3 0 0 3 3 3 0 Poxvirus A21 Protein CwfJ_C_1 PF04677.15 KII65120.1 - 1e-09 38.3 0.2 1.3e-09 37.9 0.2 1.1 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 DUF5412 PF17428.2 KII65120.1 - 0.064 13.1 0.0 0.089 12.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5412) Hemopexin PF00045.19 KII65120.1 - 0.11 12.5 0.0 0.92 9.5 0.1 2.3 2 0 0 2 2 2 0 Hemopexin Sec7 PF01369.20 KII65122.1 - 0.014 15.1 0.8 0.036 13.7 0.8 1.7 1 0 0 1 1 1 0 Sec7 domain SNAP PF14938.6 KII65124.1 - 1.6e-15 57.3 3.5 2.2e-15 56.9 3.5 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII65124.1 - 1.7e-05 25.0 2.3 0.0022 18.2 0.9 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII65124.1 - 0.015 15.5 6.0 8.6 6.9 0.0 4.3 1 1 3 4 4 4 0 Tetratricopeptide repeat TDA11 PF17084.5 KII65124.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Topoisomerase I damage affected protein 11 TPR_11 PF13414.6 KII65124.1 - 0.17 11.6 3.8 4.3 7.1 0.2 3.3 3 1 0 3 3 3 0 TPR repeat NSF PF02071.20 KII65124.1 - 0.34 11.8 4.3 35 5.8 0.1 4.6 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat DDE_3 PF13358.6 KII65125.1 - 1.5e-07 31.3 0.0 2.3e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease FERM_N PF09379.10 KII65128.1 - 2e-06 27.6 0.0 6.4e-06 26.0 0.0 1.9 1 0 0 1 1 1 1 FERM N-terminal domain CRR7 PF12095.8 KII65128.1 - 0.68 10.4 7.2 1.6 9.2 1.1 2.7 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Adhes-Ig_like PF09085.10 KII65129.1 - 0.056 13.6 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 Adhesion molecule, immunoglobulin-like PBP PF01161.20 KII65130.1 - 9.6e-06 25.9 0.0 1.1e-05 25.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein SOG2 PF10428.9 KII65130.1 - 0.15 11.3 0.2 0.18 11.0 0.2 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein PBP PF01161.20 KII65131.1 - 1.1e-08 35.5 0.0 1.2e-08 35.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein GIY-YIG PF01541.24 KII65135.1 - 0.025 14.9 0.2 0.04 14.2 0.2 1.3 1 0 0 1 1 1 0 GIY-YIG catalytic domain Fusion_F0 PF13044.6 KII65135.1 - 0.049 12.3 0.0 0.06 12.0 0.0 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0, Isavirus zf-H2C2_5 PF13909.6 KII65136.1 - 0.02 14.6 6.4 0.065 13.0 0.2 2.8 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 KII65136.1 - 0.023 15.5 7.8 0.28 12.1 0.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KII65136.1 - 0.041 14.2 4.8 0.22 11.8 0.6 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KII65136.1 - 0.045 14.2 10.7 0.12 12.9 1.2 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KII65136.1 - 0.1 13.1 9.8 0.88 10.1 1.0 2.8 3 0 0 3 3 3 0 Zinc-finger double domain Integrase_H2C2 PF17921.1 KII65137.1 - 5.2e-19 68.1 0.2 9.7e-19 67.2 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII65137.1 - 1.1e-07 32.1 0.0 1.7e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII65137.1 - 2.3e-07 30.9 0.0 4.2e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger DUF2272 PF10030.9 KII65137.1 - 0.018 14.8 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2272) Dynamin_N PF00350.23 KII65138.1 - 4.5e-47 160.2 0.1 7.5e-47 159.5 0.1 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 KII65138.1 - 9.4e-45 153.0 0.1 1.4e-44 152.5 0.1 1.2 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 KII65138.1 - 3.1e-05 24.0 0.1 6.5e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KII65138.1 - 0.0099 16.3 0.0 0.034 14.5 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 KII65138.1 - 0.016 15.4 0.0 0.039 14.2 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KII65138.1 - 0.11 12.1 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 Ras family GED PF02212.18 KII65139.1 - 1.7e-10 40.9 3.5 2.1e-10 40.6 3.5 1.1 1 0 0 1 1 1 1 Dynamin GTPase effector domain Spc7 PF08317.11 KII65145.1 - 0.0015 17.5 5.3 0.0016 17.4 5.3 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KII65145.1 - 0.055 13.5 5.1 0.12 12.4 5.1 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Methyltransf_PK PF05891.12 KII65145.1 - 0.1 12.1 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Salp15 PF12115.8 KII65145.1 - 0.12 12.8 0.0 0.16 12.4 0.0 1.3 1 1 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation L_lactis_ph-MCP PF06673.11 KII65145.1 - 0.34 9.8 2.8 0.43 9.5 2.8 1.1 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein SWI2_SNF2 PF18766.1 KII65147.1 - 0.049 13.3 0.0 0.057 13.1 0.0 1.1 1 0 0 1 1 1 0 SWI2/SNF2 ATPase IMS PF00817.20 KII65153.1 - 5.1e-40 136.9 0.0 1.4e-39 135.5 0.0 1.8 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 KII65153.1 - 2.7e-13 50.7 0.1 8.6e-13 49.0 0.1 1.8 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain RNF220 PF15926.5 KII65153.1 - 0.0012 18.5 1.0 0.002 17.8 1.0 1.3 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 IMS_HHH PF11798.8 KII65153.1 - 0.049 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif mCpol PF18182.1 KII65153.1 - 0.092 13.1 0.6 1.6 9.1 0.0 3.1 2 1 1 3 3 3 0 minimal CRISPR polymerase domain zf-Di19 PF05605.12 KII65153.1 - 0.11 12.9 0.3 0.31 11.4 0.3 1.8 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding SSXT PF05030.12 KII65154.1 - 0.035 13.7 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 SSXT protein (N-terminal region) Spore_YhcN_YlaJ PF09580.10 KII65156.1 - 0.13 12.4 0.1 0.23 11.5 0.1 1.4 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF1686 PF07937.11 KII65156.1 - 0.16 11.8 0.0 0.2 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1686) Gene66 PF02053.15 KII65158.1 - 0.061 13.0 0.1 0.069 12.8 0.1 1.1 1 0 0 1 1 1 0 Gene 66 (IR5) protein XTBD PF11952.8 KII65160.1 - 0.048 13.4 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD DsrC PF04358.13 KII65160.1 - 0.097 13.2 0.1 0.23 12.0 0.1 1.6 1 1 0 1 1 1 0 DsrC like protein rve PF00665.26 KII65161.1 - 4.9e-07 29.9 0.1 9e-07 29.1 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65161.1 - 2.3e-05 24.1 0.2 5.1e-05 23.0 0.2 1.7 1 0 0 1 1 1 1 Integrase core domain zf-UBR PF02207.20 KII65162.1 - 9.5e-12 44.9 13.3 1e-11 44.8 11.8 1.9 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-UBR PF02207.20 KII65163.1 - 1.7e-06 28.1 5.2 1.7e-06 28.1 5.2 1.6 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) DUF1884 PF08967.10 KII65164.1 - 0.1 12.9 0.2 0.28 11.4 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1884) zf-RVT PF13966.6 KII65166.1 - 0.0061 17.3 0.0 0.0082 16.8 0.0 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RHH_8 PF17723.1 KII65166.1 - 0.066 13.4 0.0 0.094 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribbon-Helix-Helix transcriptional regulator family C5HCH PF17982.1 KII65168.1 - 0.14 12.4 0.9 0.14 12.4 0.9 1.7 2 0 0 2 2 2 0 NSD Cys-His rich domain DUF768 PF05589.11 KII65168.1 - 0.14 12.2 0.0 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF768) Gtr1_RagA PF04670.12 KII65170.1 - 0.0054 16.1 0.4 0.01 15.2 0.4 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PHB_acc_N PF07879.11 KII65174.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 PHB/PHA accumulation regulator DNA-binding domain DDE_3 PF13358.6 KII65176.1 - 1.3e-12 47.7 0.0 2.6e-12 46.7 0.0 1.5 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII65178.1 - 0.012 16.2 0.0 0.08 13.6 0.0 1.9 1 1 1 2 2 2 0 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII65178.1 - 0.096 12.9 0.1 0.26 11.6 0.0 1.8 2 0 0 2 2 2 0 Transposase HTH_33 PF13592.6 KII65178.1 - 0.12 12.0 0.2 0.68 9.6 0.0 2.3 3 0 0 3 3 3 0 Winged helix-turn helix DUF1359 PF07097.11 KII65178.1 - 0.13 12.6 1.4 2.1 8.6 1.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1359) DUF1380 PF07128.12 KII65179.1 - 0.069 13.3 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1380) BUD22 PF09073.10 KII65179.1 - 0.17 11.2 9.0 0.2 11.0 9.0 1.1 1 0 0 1 1 1 0 BUD22 Ints3 PF10189.9 KII65181.1 - 4.3e-42 143.9 0.4 5.5e-42 143.6 0.4 1.1 1 0 0 1 1 1 1 Integrator complex subunit 3 SNAP PF14938.6 KII65186.1 - 3e-08 33.4 0.3 3.5e-08 33.2 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP rve PF00665.26 KII65187.1 - 1.5e-05 25.2 0.0 2.2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Dimer_Tnp_hAT PF05699.14 KII65188.1 - 3.1e-08 33.3 0.0 4.1e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Serpin PF00079.20 KII65191.1 - 1.2e-35 123.6 4.5 1.4e-35 123.4 4.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) THB PF18362.1 KII65191.1 - 0.015 14.9 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 Tri-helix bundle domain Serpin PF00079.20 KII65192.1 - 7.7e-43 147.2 3.5 8.3e-43 147.1 3.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SPT16 PF08644.11 KII65192.1 - 0.05 13.8 0.2 0.12 12.5 0.2 1.6 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) Serpin PF00079.20 KII65193.1 - 1.1e-22 80.8 0.6 1.2e-22 80.7 0.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII65194.1 - 7.7e-13 48.5 0.1 8.2e-13 48.4 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) AIG1 PF04548.16 KII65194.1 - 0.16 11.2 0.4 1.9 7.7 0.1 2.0 1 1 1 2 2 2 0 AIG1 family Serpin PF00079.20 KII65195.1 - 1.4e-58 199.0 6.5 1.6e-58 198.8 6.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) THF_DHG_CYH_C PF02882.19 KII65202.1 - 0.0064 15.8 0.0 0.0072 15.7 0.0 1.1 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF3232 PF11554.8 KII65203.1 - 0.027 14.8 0.1 0.036 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3232) DUF2555 PF10742.9 KII65204.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) TSP_C PF05735.12 KII65205.1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Thrombospondin C-terminal region SHS2_Rpb7-N PF03876.17 KII65209.1 - 3e-14 53.1 0.0 7.1e-14 51.9 0.0 1.7 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 KII65209.1 - 6.4e-12 45.7 0.0 9.8e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 KII65209.1 - 0.0013 19.0 0.0 0.0019 18.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Vps8 PF12816.7 KII65211.1 - 1.4e-15 57.3 3.2 6.3e-10 38.9 0.5 2.4 1 1 1 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 BTB_2 PF02214.22 KII65211.1 - 0.1 13.0 0.9 0.61 10.5 0.1 2.5 1 1 2 3 3 3 0 BTB/POZ domain PurA PF04845.13 KII65212.1 - 1.4e-11 44.2 0.1 0.00061 19.2 0.0 3.0 2 1 1 3 3 3 3 PurA ssDNA and RNA-binding protein Nop16 PF09420.10 KII65215.1 - 1.6e-06 28.3 0.1 1.6e-06 28.3 0.1 2.0 1 1 1 2 2 2 1 Ribosome biogenesis protein Nop16 EKLF_TAD2 PF16833.5 KII65216.1 - 0.73 9.9 4.3 1.2 9.3 4.3 1.3 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 2 API5 PF05918.11 KII65218.1 - 1.2e-66 225.6 0.0 1.4e-66 225.4 0.0 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT PF02985.22 KII65218.1 - 0.0039 17.3 0.5 0.015 15.5 0.0 2.2 2 0 0 2 2 2 1 HEAT repeat IFN-gamma PF00714.17 KII65218.1 - 0.035 14.0 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 Interferon gamma HEAT_2 PF13646.6 KII65218.1 - 0.037 14.4 0.0 0.088 13.2 0.0 1.7 1 0 0 1 1 1 0 HEAT repeats Cnd1 PF12717.7 KII65218.1 - 0.15 12.0 0.3 5 7.1 0.0 2.4 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HIT PF01230.23 KII65221.1 - 6.4e-05 23.6 0.1 0.00012 22.7 0.1 1.4 1 0 0 1 1 1 1 HIT domain CENP-B_N PF04218.13 KII65225.1 - 0.00046 19.8 0.0 0.0014 18.3 0.0 1.8 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DUF4570 PF15134.6 KII65225.1 - 0.11 12.6 0.7 0.24 11.5 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) DDE_3 PF13358.6 KII65226.1 - 6e-18 65.0 0.0 8.5e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_hydro_18 PF00704.28 KII65226.1 - 0.093 12.4 0.0 0.099 12.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 RRM_1 PF00076.22 KII65227.1 - 1.5e-16 60.0 0.1 7e-10 38.6 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 KII65227.1 - 0.0012 18.7 0.0 0.013 15.3 0.0 2.1 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRM_3 PF08777.11 KII65227.1 - 0.0058 16.6 0.0 0.8 9.8 0.1 2.2 2 0 0 2 2 2 1 RNA binding motif BRAP2 PF07576.12 KII65227.1 - 0.009 16.2 0.0 0.049 13.8 0.0 2.0 2 0 0 2 2 2 1 BRCA1-associated protein 2 SinI PF08671.10 KII65227.1 - 0.036 13.8 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Anti-repressor SinI Limkain-b1 PF11608.8 KII65227.1 - 0.041 14.0 0.1 0.11 12.5 0.1 1.8 1 1 0 1 1 1 0 Limkain b1 RRM_occluded PF16842.5 KII65227.1 - 0.06 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Med18 PF09637.10 KII65228.1 - 0.00081 19.3 0.0 0.021 14.6 0.0 2.0 1 1 1 2 2 2 2 Med18 protein MMR_HSR1 PF01926.23 KII65231.1 - 9.3e-07 28.9 0.0 9.9e-05 22.4 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KII65231.1 - 0.0012 18.8 0.1 0.0076 16.2 0.1 2.2 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 KII65231.1 - 0.0013 18.3 0.4 1.8 8.1 0.0 2.7 2 0 0 2 2 2 2 Ferrous iron transport protein B G-alpha PF00503.20 KII65231.1 - 0.029 13.5 0.7 1.2 8.2 0.1 2.2 2 0 0 2 2 2 0 G-protein alpha subunit GTP_EFTU PF00009.27 KII65231.1 - 0.13 11.8 0.2 9.6 5.7 0.0 2.4 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain zf-C2HE PF16278.5 KII65231.1 - 0.19 12.2 1.5 0.22 12.0 0.0 1.9 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Ras PF00071.22 KII65231.1 - 0.19 11.3 0.0 12 5.5 0.0 2.7 2 0 0 2 2 2 0 Ras family CAF1A PF12253.8 KII65232.1 - 0.11 12.7 0.8 0.2 11.9 0.8 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A rve PF00665.26 KII65233.1 - 1.4e-16 60.8 0.0 2.3e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65233.1 - 0.00042 20.0 0.3 0.0037 17.0 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain DUF5344 PF17279.2 KII65233.1 - 0.074 13.6 0.6 2.7 8.6 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DDE_Tnp_IS240 PF13610.6 KII65233.1 - 0.1 12.8 1.9 0.11 12.8 0.1 1.9 2 1 0 2 2 2 0 DDE domain Abhydrolase_1 PF00561.20 KII65234.1 - 7.8e-05 22.4 0.1 0.00011 21.9 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KII65234.1 - 0.00011 21.5 0.0 0.00013 21.3 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KII65234.1 - 0.00029 21.5 0.0 0.00044 20.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF818 PF05677.12 KII65234.1 - 0.0005 19.1 0.1 0.00065 18.8 0.1 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) DUF1057 PF06342.12 KII65234.1 - 0.015 14.3 0.1 0.021 13.9 0.1 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_3 PF07859.13 KII65234.1 - 0.1 12.4 0.5 0.2 11.5 0.5 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 KII65234.1 - 0.15 11.7 0.1 0.21 11.2 0.1 1.1 1 0 0 1 1 1 0 Putative esterase Asp2 PF16929.5 KII65234.1 - 0.25 10.3 0.1 0.32 9.9 0.1 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter RhoGAP PF00620.27 KII65235.1 - 1.2e-08 34.9 0.0 2.6e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain DUF2816 PF10992.8 KII65235.1 - 0.1 12.5 0.3 6 6.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2816) Pkinase PF00069.25 KII65236.1 - 2.1e-70 237.1 0.0 2.8e-70 236.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII65236.1 - 5.4e-35 120.9 0.0 7.8e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KII65236.1 - 9.7e-09 34.6 0.1 9.7e-09 34.6 0.1 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 KII65236.1 - 8e-05 22.1 0.0 0.0013 18.1 0.0 2.1 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KII65236.1 - 0.00066 19.1 0.3 0.0012 18.3 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KII65236.1 - 8.2 5.1 9.0 1.5 7.5 0.0 2.5 3 0 0 3 3 3 0 Fungal protein kinase UPF0220 PF05255.11 KII65238.1 - 0.0049 16.4 4.1 0.0098 15.5 4.1 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF2798 PF11391.8 KII65238.1 - 7.1 6.7 14.4 0.79 9.8 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2798) DDE_3 PF13358.6 KII65239.1 - 6.3e-17 61.7 0.0 1e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Arg_repressor PF01316.21 KII65239.1 - 8.3e-07 28.7 0.2 8.3e-07 28.7 0.2 2.2 3 0 0 3 3 3 1 Arginine repressor, DNA binding domain HTH_38 PF13936.6 KII65239.1 - 8.3e-05 22.3 0.2 0.0092 15.7 0.1 2.7 2 0 0 2 2 2 1 Helix-turn-helix domain DDE_Tnp_ISAZ013 PF07592.11 KII65239.1 - 0.018 14.1 0.1 0.93 8.4 0.0 2.2 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain HTH_Tnp_Tc3_2 PF01498.18 KII65239.1 - 0.024 14.9 2.6 0.035 14.4 0.4 2.4 2 0 0 2 2 2 0 Transposase HTH_33 PF13592.6 KII65239.1 - 0.027 14.1 0.0 0.07 12.8 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix PspA_IM30 PF04012.12 KII65239.1 - 0.047 13.3 0.1 8.7 5.9 0.0 2.2 2 0 0 2 2 2 0 PspA/IM30 family DUF3368 PF11848.8 KII65239.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) TRAPP PF04051.16 KII65240.1 - 1.4e-12 47.6 0.0 2.5e-12 46.7 0.0 1.4 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component efThoc1 PF11957.8 KII65241.1 - 3.4e-21 75.5 3.4 4.4e-21 75.1 3.4 1.0 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Kelch_6 PF13964.6 KII65244.1 - 2.3e-23 81.6 10.1 6.7e-07 29.4 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KII65244.1 - 8.1e-15 54.1 11.6 1.9e-06 27.3 0.1 6.6 7 0 0 7 7 7 3 Kelch motif Kelch_4 PF13418.6 KII65244.1 - 9.7e-10 38.3 11.7 0.0016 18.4 0.2 5.7 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII65244.1 - 2.8e-09 36.7 1.5 0.0048 16.9 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 KII65244.1 - 8.2e-08 31.9 7.1 0.048 13.7 0.1 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII65244.1 - 7.9e-05 22.8 8.5 0.58 10.5 0.0 6.0 6 1 1 7 7 7 1 Galactose oxidase, central domain pEK499_p136 PF18736.1 KII65247.1 - 0.088 12.4 0.1 0.14 11.8 0.1 1.3 1 1 0 1 1 1 0 HEPN pEK499 p136 Serpin PF00079.20 KII65249.1 - 7.1e-22 78.2 0.8 7.6e-22 78.1 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.26 KII65250.1 - 1.4e-22 80.1 0.0 2.1e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65250.1 - 9.8e-15 54.4 0.6 2.1e-14 53.4 0.6 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII65250.1 - 0.0016 18.2 0.0 0.0043 16.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain IglC PF11550.8 KII65250.1 - 0.15 11.5 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 Intracellular growth locus C protein Peptidase_M3 PF01432.20 KII65253.1 - 1.2e-52 179.8 0.9 1.7e-52 179.2 0.9 1.1 1 0 0 1 1 1 1 Peptidase family M3 Beach PF02138.18 KII65254.1 - 0.013 14.9 0.0 0.039 13.3 0.0 1.7 2 0 0 2 2 2 0 Beige/BEACH domain zf-UBR PF02207.20 KII65255.1 - 2e-12 47.1 14.8 5.1e-12 45.8 14.8 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) TIR_2 PF13676.6 KII65255.1 - 0.055 14.1 0.1 0.16 12.6 0.1 1.8 1 0 0 1 1 1 0 TIR domain FBD PF08387.10 KII65255.1 - 0.63 10.0 7.3 0.13 12.2 0.7 3.1 3 0 0 3 3 3 0 FBD EMP24_GP25L PF01105.24 KII65261.1 - 1.1e-11 45.0 1.1 1e-05 25.6 0.3 2.0 2 0 0 2 2 2 2 emp24/gp25L/p24 family/GOLD E1-E2_ATPase PF00122.20 KII65261.1 - 0.24 10.9 0.7 0.36 10.3 0.7 1.2 1 0 0 1 1 1 0 E1-E2 ATPase SNAP PF14938.6 KII65263.1 - 2.2e-06 27.3 0.0 3.8e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF2087 PF09860.9 KII65263.1 - 0.028 14.6 0.0 0.21 11.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) MRG PF05712.13 KII65263.1 - 0.04 13.2 0.1 0.056 12.8 0.1 1.4 1 0 0 1 1 1 0 MRG GGDEF_2 PF17853.1 KII65263.1 - 0.11 12.7 0.0 0.49 10.7 0.0 1.9 2 0 0 2 2 2 0 GGDEF-like domain RVT_1 PF00078.27 KII65266.1 - 4.8e-22 78.6 0.1 6.6e-22 78.1 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PTN_MK_C PF01091.18 KII65267.1 - 0.088 13.2 0.5 0.21 12.0 0.0 1.7 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, C-terminal domain PPO1_KFDV PF12143.8 KII65267.1 - 0.17 12.0 0.0 0.25 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF_B2219) GCP_N_terminal PF17681.1 KII65270.1 - 3.1e-13 50.0 0.3 3.8e-11 43.2 0.1 2.1 2 0 0 2 2 2 2 Gamma tubulin complex component N-terminal ISP3_C PF18045.1 KII65271.1 - 0.013 15.4 0.3 0.026 14.4 0.0 1.6 2 0 0 2 2 2 0 ISP3 C-terminal ISP1_C PF18161.1 KII65271.1 - 0.027 14.5 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 ISP1 C-terminal HLH PF00010.26 KII65271.1 - 0.059 13.3 0.1 0.094 12.7 0.1 1.3 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain zf-RING_UBOX PF13445.6 KII65271.1 - 0.11 12.5 0.1 0.18 11.9 0.1 1.4 1 1 0 1 1 1 0 RING-type zinc-finger DUF5638 PF18688.1 KII65272.1 - 0.0026 18.1 2.1 0.0042 17.4 2.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5638) IL5 PF02025.15 KII65273.1 - 0.036 14.3 0.1 0.044 14.1 0.1 1.2 1 0 0 1 1 1 0 Interleukin 5 Proteasome PF00227.26 KII65275.1 - 5.1e-44 150.0 1.4 6.2e-44 149.8 1.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Dimer_Tnp_hAT PF05699.14 KII65276.1 - 3.8e-16 58.7 0.5 5.1e-16 58.2 0.5 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region PLDc_2 PF13091.6 KII65277.1 - 3.4e-16 59.3 1.8 4.1e-10 39.7 0.8 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc_3 PF13918.6 KII65277.1 - 0.00016 21.4 0.5 0.087 12.5 0.1 2.5 2 0 0 2 2 2 2 PLD-like domain Cullin PF00888.22 KII65278.1 - 6.8e-08 31.6 0.0 8.2e-08 31.3 0.0 1.1 1 0 0 1 1 1 1 Cullin family STAG PF08514.11 KII65278.1 - 0.024 14.6 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 STAG domain Cullin PF00888.22 KII65279.1 - 2.6e-16 59.4 0.0 3e-16 59.2 0.0 1.0 1 0 0 1 1 1 1 Cullin family NLE PF08154.12 KII65281.1 - 0.093 13.3 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 NLE (NUC135) domain Borrelia_orfX PF04160.12 KII65283.1 - 0.028 14.4 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Orf-X protein TaqI_C PF12950.7 KII65283.1 - 0.041 13.9 0.1 0.049 13.7 0.1 1.2 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain GLTSCR1 PF15249.6 KII65284.1 - 2 8.9 5.4 9 6.8 0.0 3.9 3 1 0 3 3 3 0 Conserved region of unknown function on GLTSCR protein Ubiq_cyt_C_chap PF03981.12 KII65286.1 - 0.19 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone DDE_3 PF13358.6 KII65289.1 - 4.1e-11 42.8 0.0 5e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.6 KII65291.1 - 4.9e-10 39.3 0.7 9.8e-10 38.3 0.7 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 KII65291.1 - 0.00063 19.5 0.7 0.0029 17.3 0.5 2.0 1 1 1 2 2 2 1 26S proteasome subunit RPN7 TPR_2 PF07719.17 KII65291.1 - 0.052 13.7 0.4 8.5 6.8 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF473 PF04322.12 KII65291.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF473) NSF PF02071.20 KII65291.1 - 0.089 13.6 3.7 1.1 10.3 0.1 3.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.6 KII65291.1 - 0.12 12.7 0.5 62 4.2 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII65291.1 - 0.27 11.1 1.5 12 5.9 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Serpin PF00079.20 KII65293.1 - 5.1e-22 78.7 2.0 5.8e-22 78.5 2.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.6 KII65294.1 - 1.9e-17 63.6 0.3 2.6e-17 63.2 0.3 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 KII65294.1 - 0.011 15.4 0.2 0.098 12.4 0.0 2.6 1 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_2 PF07719.17 KII65294.1 - 0.022 14.9 1.9 0.76 10.0 0.4 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII65294.1 - 0.13 12.5 3.3 0.47 10.8 0.3 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Sigma70_r1_1 PF03979.14 KII65294.1 - 0.15 12.1 0.2 0.38 10.8 0.2 1.6 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 TPR_1 PF00515.28 KII65294.1 - 2.5 8.1 6.4 5.2 7.1 0.8 4.3 5 1 0 5 5 5 0 Tetratricopeptide repeat SNAP PF14938.6 KII65295.1 - 3.1e-06 26.8 0.1 3.5e-06 26.6 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 KII65295.1 - 0.0028 17.6 0.1 0.31 11.3 0.0 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KII65295.1 - 0.0071 16.1 0.0 0.72 9.8 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat Csm2_III-A PF03750.13 KII65295.1 - 0.043 14.6 0.5 0.13 13.1 0.1 2.0 1 1 1 2 2 2 0 Csm2 Type III-A DDE_3 PF13358.6 KII65296.1 - 6.8e-09 35.6 0.1 2.5e-08 33.8 0.1 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease ApoM PF11032.8 KII65296.1 - 0.023 14.4 0.0 0.028 14.1 0.0 1.1 1 0 0 1 1 1 0 ApoM domain zf-CCHC PF00098.23 KII65298.1 - 0.0082 16.2 1.2 0.0082 16.2 1.2 2.5 2 0 0 2 2 2 1 Zinc knuckle DpnI PF06044.12 KII65298.1 - 0.039 13.6 0.8 0.061 13.0 0.8 1.3 1 0 0 1 1 1 0 Dam-replacing family Mo-nitro_C PF06967.11 KII65299.1 - 0.022 14.7 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus Glyc_hyd_38C_2 PF18230.1 KII65299.1 - 0.057 13.5 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal sub-domain rve PF00665.26 KII65300.1 - 4.3e-24 85.0 0.0 5.4e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65300.1 - 6.6e-06 25.8 0.1 1.1e-05 25.2 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 KII65303.1 - 0.00021 21.4 0.0 0.00065 19.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65303.1 - 0.00072 19.3 0.0 0.0018 18.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65303.1 - 0.29 11.3 2.3 1.2 9.3 0.9 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain RVT_1 PF00078.27 KII65304.1 - 0.00066 19.3 0.2 0.00079 19.0 0.2 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII65305.1 - 2.2e-08 34.3 0.0 4.2e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain 2C_adapt PF08793.10 KII65305.1 - 0.33 11.2 1.8 6.7 7.0 0.0 3.2 3 0 0 3 3 3 0 2-cysteine adaptor domain DUF2274 PF10038.9 KII65307.1 - 0.11 13.0 0.1 0.18 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) Imm47 PF15573.6 KII65307.1 - 0.12 11.9 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 47 Spuma_A9PTase PF03539.14 KII65308.1 - 0.1 12.7 0.1 0.97 9.6 0.0 2.0 1 1 1 2 2 2 0 Spumavirus aspartic protease (A9) rve PF00665.26 KII65310.1 - 6.9e-13 48.8 0.0 9.1e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65310.1 - 0.0064 16.3 0.0 0.1 12.4 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_1_2 PF13586.6 KII65310.1 - 0.055 13.8 0.2 0.17 12.3 0.1 1.7 2 0 0 2 2 2 0 Transposase DDE domain gag-asp_proteas PF13975.6 KII65311.1 - 0.028 15.0 0.0 0.046 14.3 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII65311.1 - 0.052 14.2 0.0 0.089 13.5 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease Ribosomal_S30 PF04758.14 KII65311.1 - 0.1 12.8 0.2 0.22 11.8 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein S30 zf-CCHC PF00098.23 KII65311.1 - 0.35 11.0 2.4 0.76 10.0 2.4 1.6 1 0 0 1 1 1 0 Zinc knuckle Sec5 PF15469.6 KII65314.1 - 0.016 15.0 0.6 4.2 7.1 0.0 2.0 1 1 1 2 2 2 0 Exocyst complex component Sec5 rve PF00665.26 KII65314.1 - 0.017 15.3 0.0 0.027 14.7 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain MULE PF10551.9 KII65317.1 - 1.8e-05 25.1 0.5 3.9e-05 24.0 0.3 1.8 2 0 0 2 2 2 1 MULE transposase domain gag-asp_proteas PF13975.6 KII65319.1 - 3.5e-07 30.7 0.1 7.1e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII65319.1 - 2.8e-05 24.7 0.1 5.9e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII65319.1 - 0.00041 20.3 4.4 0.00093 19.2 4.4 1.6 1 0 0 1 1 1 1 Zinc knuckle RVP PF00077.20 KII65319.1 - 0.0029 17.9 0.0 0.0083 16.4 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KII65319.1 - 0.029 14.1 0.2 0.14 12.0 0.1 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease Asp_protease PF09668.10 KII65319.1 - 0.039 13.8 0.1 0.085 12.7 0.1 1.6 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.6 KII65319.1 - 0.041 13.6 1.4 0.073 12.8 1.4 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 KII65319.1 - 0.05 13.6 0.2 0.096 12.7 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII65319.1 - 0.076 13.1 0.1 0.17 12.0 0.1 1.6 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) ARTD15_N PF18084.1 KII65319.1 - 0.078 13.2 0.1 6.9 7.0 0.0 3.4 4 0 0 4 4 3 0 ARTD15 N-terminal domain zf-CCHC_4 PF14392.6 KII65319.1 - 0.11 12.3 1.8 0.27 11.0 1.8 1.7 1 0 0 1 1 1 0 Zinc knuckle NTP_transf_2 PF01909.23 KII65319.1 - 0.14 12.5 0.0 0.38 11.1 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain Pox_A_type_inc PF04508.12 KII65319.1 - 0.23 11.4 3.6 0.4 10.6 0.8 2.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat RT_RNaseH PF17917.1 KII65320.1 - 2.6e-31 108.0 0.7 7.8e-31 106.5 0.1 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65320.1 - 2.5e-22 78.8 0.0 4.7e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII65320.1 - 4.1e-19 68.9 0.0 3.3e-18 66.0 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65320.1 - 2.7e-18 65.8 1.0 4.8e-18 65.0 0.1 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain MLVIN_C PF18697.1 KII65320.1 - 2e-05 24.6 0.7 0.1 12.7 0.1 2.6 2 0 0 2 2 2 2 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII65320.1 - 0.00067 19.4 0.0 0.0018 18.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII65320.1 - 0.0013 18.9 0.0 0.0042 17.3 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger MMR_HSR1 PF01926.23 KII65322.1 - 8.2e-18 64.6 0.0 1e-13 51.4 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase GN3L_Grn1 PF08701.11 KII65322.1 - 5.6e-13 48.8 12.2 5.6e-13 48.8 12.2 2.1 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase FeoB_N PF02421.18 KII65322.1 - 4.4e-10 39.3 0.8 2.4e-08 33.7 0.1 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KII65322.1 - 0.00014 21.9 6.3 0.00028 21.0 1.0 3.4 2 2 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 KII65322.1 - 0.00017 21.6 0.3 0.0015 18.5 0.3 2.4 1 1 0 1 1 1 1 RsgA GTPase cobW PF02492.19 KII65322.1 - 0.0045 16.6 0.1 0.052 13.1 0.0 2.4 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 KII65322.1 - 0.011 15.1 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AIG1 PF04548.16 KII65322.1 - 0.016 14.6 1.2 0.031 13.6 1.2 1.5 1 0 0 1 1 1 0 AIG1 family AAA_16 PF13191.6 KII65322.1 - 0.018 15.4 0.1 0.2 12.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Arf PF00025.21 KII65322.1 - 0.022 14.2 0.2 1.3 8.5 0.0 2.5 1 1 1 2 2 2 0 ADP-ribosylation factor family MeaB PF03308.16 KII65322.1 - 0.027 13.5 0.1 0.049 12.6 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 KII65322.1 - 0.076 12.5 0.2 1.2 8.6 0.0 2.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Roc PF08477.13 KII65322.1 - 0.15 12.3 0.1 21 5.3 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 KII65322.1 - 0.21 12.1 0.0 0.21 12.1 0.0 2.7 5 0 0 5 5 4 0 AAA domain RRM_1 PF00076.22 KII65323.1 - 3.3e-27 94.1 1.3 3.3e-18 65.3 0.0 3.4 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KII65323.1 - 1.1e-07 31.7 0.1 0.00021 21.2 0.1 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 KII65323.1 - 4.4e-05 23.4 1.5 0.0055 16.6 1.3 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Phage_TAC_13 PF16459.5 KII65323.1 - 0.0032 17.9 3.1 0.77 10.2 1.5 2.4 2 0 0 2 2 2 2 Phage tail assembly chaperone, TAC RRM_7 PF16367.5 KII65323.1 - 0.0092 16.1 1.4 7.5 6.8 0.0 3.0 2 2 0 2 2 2 2 RNA recognition motif HTH_Tnp_Tc3_2 PF01498.18 KII65324.1 - 0.0074 16.5 1.1 0.014 15.6 0.8 1.7 1 1 0 1 1 1 1 Transposase HTH_Tnp_Tc3_1 PF11427.8 KII65324.1 - 0.048 13.5 0.1 0.19 11.6 0.0 1.9 1 1 1 2 2 2 0 Tc3 transposase Vasohibin PF14822.6 KII65325.1 - 0.024 13.9 0.0 0.041 13.1 0.0 1.4 1 0 0 1 1 1 0 Vasohibin DDE_3 PF13358.6 KII65326.1 - 6.5e-05 22.7 0.0 8.5e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_S8 PF00082.22 KII65327.1 - 4.3e-26 91.9 0.0 7e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KII65327.1 - 1.8e-12 47.1 0.0 4.6e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain Flavoprotein PF02441.19 KII65328.1 - 3.3e-35 121.2 0.0 4.1e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein TAXi_C PF14541.6 KII65328.1 - 0.004 16.9 0.0 0.0081 15.9 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Fe-S_biosyn PF01521.20 KII65329.1 - 2.1e-14 53.6 0.1 2.4e-14 53.4 0.1 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis RT_RNaseH_2 PF17919.1 KII65330.1 - 2e-39 133.6 0.0 5.1e-39 132.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65330.1 - 9.4e-36 122.3 0.1 2.8e-35 120.8 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65330.1 - 5.3e-31 107.9 0.5 1.3e-30 106.6 0.5 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII65330.1 - 9.2e-18 64.6 0.0 2.1e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65330.1 - 1.5e-16 60.3 0.4 3.6e-16 59.0 0.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII65330.1 - 6.9e-06 26.5 0.0 4e-05 24.1 0.0 2.3 3 0 0 3 3 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII65330.1 - 4.6e-05 23.3 3.9 0.00014 21.8 3.9 1.9 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 KII65330.1 - 0.00047 20.8 0.1 0.0022 18.6 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-H2C2 PF09337.10 KII65330.1 - 0.0008 19.6 0.4 0.0025 18.0 0.4 1.9 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII65330.1 - 0.013 15.3 0.1 0.13 12.1 0.0 2.8 2 0 0 2 2 2 0 Integrase core domain zf-CCHC_4 PF14392.6 KII65330.1 - 0.019 14.7 1.3 0.071 12.9 1.3 2.0 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII65330.1 - 0.025 14.7 0.0 0.064 13.4 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP PF00077.20 KII65330.1 - 0.067 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Reprolysin_5 PF13688.6 KII65331.1 - 1.2e-12 48.4 0.0 1.9e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 KII65331.1 - 3e-12 46.8 0.0 4.4e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KII65331.1 - 5.5e-06 26.2 0.1 1e-05 25.3 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 KII65331.1 - 5.3e-05 23.7 0.0 0.00013 22.5 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 KII65331.1 - 0.0082 16.1 0.2 0.017 15.1 0.2 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease RPN7 PF10602.9 KII65331.1 - 0.043 13.5 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Ras PF00071.22 KII65332.1 - 6.6e-59 198.1 0.3 8e-59 197.9 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII65332.1 - 1.6e-38 131.6 0.0 2.7e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII65332.1 - 1.2e-12 47.6 0.1 1.6e-12 47.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII65332.1 - 9e-08 31.8 0.1 1e-07 31.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KII65332.1 - 2.3e-06 27.6 0.0 0.0021 18.0 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KII65332.1 - 5.7e-06 26.0 0.0 0.00033 20.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KII65332.1 - 1.1e-05 25.4 0.0 2.1e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KII65332.1 - 5e-05 22.8 0.0 6.7e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 KII65332.1 - 0.017 15.2 0.1 1.5 8.8 0.0 2.5 2 1 0 2 2 2 0 Dynamin family AAA_15 PF13175.6 KII65332.1 - 0.018 14.7 0.1 0.022 14.5 0.1 1.2 1 0 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 KII65332.1 - 0.022 14.7 0.0 0.042 13.8 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 KII65332.1 - 0.034 14.2 0.1 0.056 13.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 KII65332.1 - 0.035 13.6 0.0 3.7 7.0 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_7 PF12775.7 KII65332.1 - 0.05 13.1 0.0 0.087 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_pol_Rpc4 PF05132.14 KII65333.1 - 0.013 15.9 2.1 0.016 15.7 2.1 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Enolase_N PF03952.16 KII65333.1 - 0.034 14.3 0.4 1.2 9.3 0.1 2.1 1 1 0 2 2 2 0 Enolase, N-terminal domain DDE_Tnp_IS1595 PF12762.7 KII65334.1 - 3.1e-10 40.3 0.0 4.8e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII65334.1 - 0.015 15.1 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease RRM_1 PF00076.22 KII65335.1 - 6.7e-32 109.1 0.0 1.4e-16 60.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII65335.1 - 3.7e-10 39.8 0.2 3.3e-06 27.1 0.0 3.0 2 2 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KII65335.1 - 2e-05 24.5 0.0 0.12 12.4 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif WD40 PF00400.32 KII65340.1 - 1.2e-16 60.8 10.6 3.1e-06 27.8 0.3 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII65340.1 - 2.3e-10 40.6 0.3 9.8e-06 25.8 0.0 3.6 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KII65340.1 - 4.9e-05 23.3 0.0 0.35 10.7 0.0 2.5 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A CdiI PF07262.11 KII65344.1 - 0.048 13.4 0.2 0.051 13.3 0.2 1.2 1 0 0 1 1 1 0 CDI immunity protein KASH_CCD PF14662.6 KII65346.1 - 0.0074 16.1 6.8 0.0097 15.7 6.8 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF5082 PF16888.5 KII65346.1 - 0.013 15.8 5.3 0.019 15.2 2.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) SH3BP5 PF05276.14 KII65346.1 - 0.018 14.8 3.8 0.51 10.1 0.0 2.1 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) ATG16 PF08614.11 KII65346.1 - 0.024 14.9 8.7 0.63 10.2 2.3 2.6 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 KII65346.1 - 0.03 14.9 10.3 0.27 11.8 3.9 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF1664 PF07889.12 KII65346.1 - 0.082 12.9 5.0 3.7 7.6 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) YabA PF06156.13 KII65346.1 - 0.29 11.8 6.0 1.6 9.4 1.0 2.6 2 1 0 2 2 2 0 Initiation control protein YabA CEP63 PF17045.5 KII65347.1 - 2.7e-05 24.2 3.0 3.1e-05 24.0 3.0 1.0 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa SYCE1 PF15233.6 KII65347.1 - 0.0042 17.1 7.5 0.048 13.7 3.7 2.1 1 1 1 2 2 2 2 Synaptonemal complex central element protein 1 Spc7 PF08317.11 KII65347.1 - 0.013 14.5 6.0 0.014 14.3 6.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Nsp1_C PF05064.13 KII65347.1 - 0.014 15.2 1.1 0.014 15.2 1.1 1.5 2 0 0 2 2 2 0 Nsp1-like C-terminal region GIT_CC PF16559.5 KII65347.1 - 0.09 12.7 2.0 0.11 12.3 0.1 2.0 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor S_2TMBeta PF18153.1 KII65347.1 - 0.1 12.3 0.3 0.15 11.8 0.3 1.3 1 0 0 1 1 1 0 SMODS-associating 2TM, beta-strand rich effector domain CENP-H PF05837.12 KII65347.1 - 1 9.8 6.1 1.2 9.6 1.9 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) TRAP-delta PF05404.12 KII65349.1 - 0.00048 19.7 0.2 0.00079 19.0 0.2 1.3 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) gag-asp_proteas PF13975.6 KII65350.1 - 7.3e-08 32.9 0.0 1.7e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.17 KII65350.1 - 0.00012 22.3 0.1 0.00032 20.9 0.1 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein Asp_protease_2 PF13650.6 KII65350.1 - 0.00013 22.5 0.0 0.0003 21.3 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII65350.1 - 0.00022 21.5 0.2 0.0028 17.9 0.1 2.6 2 1 0 2 2 2 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII65350.1 - 0.00075 19.3 0.2 0.002 17.9 0.2 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII65350.1 - 0.00076 19.4 1.1 0.0014 18.7 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle Peptidase_A2E PF12382.8 KII65350.1 - 0.0019 18.2 0.0 0.0035 17.3 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon peptidase zf-CCHC_5 PF14787.6 KII65350.1 - 0.014 15.1 1.4 0.023 14.4 1.4 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RVP_2 PF08284.11 KII65350.1 - 0.08 12.7 0.3 0.23 11.3 0.3 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease Arc_C PF18162.1 KII65350.1 - 0.097 12.5 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Arc C-lobe zf-CCHC_2 PF13696.6 KII65350.1 - 0.19 11.6 1.5 0.42 10.5 1.5 1.6 1 0 0 1 1 1 0 Zinc knuckle SlyX PF04102.12 KII65350.1 - 0.23 12.1 0.3 0.23 12.1 0.3 2.3 2 0 0 2 2 2 0 SlyX EGF_2 PF07974.13 KII65352.1 - 0.022 15.1 7.0 0.041 14.3 7.0 1.5 1 0 0 1 1 1 0 EGF-like domain Antimicrobial25 PF16839.5 KII65352.1 - 0.059 13.5 2.2 0.09 12.9 2.2 1.3 1 0 0 1 1 1 0 Nematode antimicrobial peptide SNAP PF14938.6 KII65355.1 - 8e-08 32.0 7.8 1.9e-07 30.8 7.8 1.7 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 KII65355.1 - 0.00035 20.3 2.0 0.00089 19.0 0.9 2.1 1 1 1 2 2 2 1 26S proteasome subunit RPN7 TPR_10 PF13374.6 KII65355.1 - 0.0018 18.1 0.9 1.1 9.2 0.1 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII65355.1 - 0.0019 18.4 1.6 7.6 6.9 0.1 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KII65355.1 - 0.0061 17.3 0.3 0.34 11.8 0.1 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KII65355.1 - 0.018 15.7 1.2 6.9 7.4 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII65355.1 - 0.045 13.9 8.8 2.5 8.4 0.2 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII65355.1 - 0.34 10.8 9.4 5.4 7.0 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 KII65355.1 - 0.59 10.3 6.0 4.9 7.4 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII65355.1 - 0.6 10.5 8.7 0.51 10.7 0.5 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat cEGF PF12662.7 KII65358.1 - 0.15 12.1 1.3 0.3 11.1 1.3 1.4 1 0 0 1 1 1 0 Complement Clr-like EGF-like Ail_Lom PF06316.11 KII65360.1 - 0.00031 20.5 8.4 5.9 6.6 0.1 4.2 3 1 0 4 4 4 3 Enterobacterial Ail/Lom protein Sld3_N PF18523.1 KII65360.1 - 0.001 19.1 5.8 12 6.1 0.1 4.3 1 1 3 4 4 4 1 Sld3 N-terminal domain Methyltransf_30 PF05430.11 KII65360.1 - 0.022 14.6 0.9 74 3.2 0.0 3.9 4 0 0 4 4 4 0 S-adenosyl-L-methionine-dependent methyltransferase GSAP-16 PF14959.6 KII65360.1 - 0.095 12.6 0.3 72 3.3 0.0 4.7 6 0 0 6 6 6 0 gamma-Secretase-activating protein C-term ADIP PF11559.8 KII65360.1 - 0.17 12.0 5.9 34 4.5 0.1 3.4 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF751 PF05421.11 KII65360.1 - 0.2 12.4 1.9 3.2e+02 2.1 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF751) DUF902 PF06001.13 KII65360.1 - 0.96 10.0 6.0 1.8e+02 2.7 0.0 4.7 5 0 0 5 5 5 0 Domain of Unknown Function (DUF902) DDE_1 PF03184.19 KII65361.1 - 0.1 12.3 0.1 0.24 11.1 0.1 1.8 1 1 0 1 1 1 0 DDE superfamily endonuclease SNAP PF14938.6 KII65362.1 - 7e-07 29.0 0.7 7e-07 29.0 0.7 1.4 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP DUF1091 PF06477.13 KII65362.1 - 0.071 13.6 5.6 0.87 10.1 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1091) DDE_Tnp_IS1595 PF12762.7 KII65364.1 - 1.4e-05 25.1 0.1 0.00025 21.1 0.1 2.3 1 1 0 1 1 1 1 ISXO2-like transposase domain ATP-synt_B PF00430.18 KII65365.1 - 0.0039 17.3 0.1 0.0054 16.8 0.1 1.3 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) PHM7_cyt PF14703.6 KII65366.1 - 0.037 14.2 0.7 0.073 13.3 0.2 1.6 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter DUF1827 PF08860.10 KII65366.1 - 0.088 13.1 0.2 0.19 12.0 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1827) DUF1189 PF06691.11 KII65370.1 - 0.023 14.3 1.2 0.026 14.1 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Insulin_TMD PF17870.1 KII65370.1 - 0.44 10.6 4.7 0.96 9.6 4.7 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment LSM PF01423.22 KII65372.1 - 4e-13 48.8 0.1 5.3e-13 48.5 0.1 1.2 1 0 0 1 1 1 1 LSM domain ADH_N PF08240.12 KII65372.1 - 0.0071 16.2 0.0 0.0091 15.9 0.0 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain MEF2_binding PF09047.10 KII65372.1 - 0.096 12.6 0.3 0.2 11.5 0.3 1.5 1 0 0 1 1 1 0 MEF2 binding Iso_dh PF00180.20 KII65374.1 - 3.7e-40 138.1 0.0 4.7e-40 137.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HTH_33 PF13592.6 KII65377.1 - 0.00015 21.4 0.1 0.00022 20.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_29 PF13551.6 KII65377.1 - 0.00061 19.8 0.1 0.0016 18.4 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 KII65377.1 - 0.00063 19.5 0.8 0.028 14.2 0.0 2.7 2 1 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 KII65377.1 - 0.00069 19.7 0.0 0.0029 17.7 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII65377.1 - 0.0091 15.9 0.1 0.016 15.1 0.0 1.4 2 0 0 2 2 2 1 'Paired box' domain DUF1323 PF07037.11 KII65377.1 - 0.029 14.8 0.0 0.043 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) Sigma_reg_C PF13791.6 KII65377.1 - 0.1 12.8 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Sigma factor regulator C-terminal Sua5_yciO_yrdC PF01300.18 KII65378.1 - 9.8e-33 113.1 0.0 1.1e-32 113.0 0.0 1.0 1 0 0 1 1 1 1 Telomere recombination S10_plectin PF03501.15 KII65379.1 - 1e-32 112.0 0.0 1.2e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 Plectin/S10 domain FLYWCH PF04500.16 KII65380.1 - 3.3e-11 43.1 2.3 7.8e-11 41.9 2.3 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain CAF1-p150_N PF15557.6 KII65380.1 - 0.0074 16.3 0.4 0.0094 15.9 0.4 1.1 1 0 0 1 1 1 1 CAF1 complex subunit p150, region binding to PCNA PTEN_C2 PF10409.9 KII65381.1 - 1.8e-08 34.2 0.5 3e-08 33.5 0.5 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 KII65381.1 - 1.2e-05 25.2 0.2 7.4e-05 22.6 0.0 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KII65381.1 - 0.00025 20.7 0.0 0.00046 19.8 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KII65381.1 - 0.00098 19.3 0.0 0.0018 18.4 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 KII65381.1 - 0.0027 17.4 0.1 0.0051 16.5 0.1 1.5 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 KII65381.1 - 0.0035 17.3 0.0 0.0064 16.5 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF1617 PF07761.12 KII65381.1 - 0.093 12.8 0.0 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1617) HU-DNA_bdg PF14848.6 KII65381.1 - 0.16 12.0 0.4 0.46 10.5 0.1 1.9 2 0 0 2 2 2 0 DNA-binding domain Ldl_recept_a PF00057.18 KII65382.1 - 1.2e-39 134.2 124.4 2.7e-09 37.1 3.4 8.3 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII65382.1 - 4.3e-26 91.7 7.5 9.2e-26 90.6 7.5 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII65382.1 - 2.4e-17 63.8 4.7 2.4e-17 63.8 4.7 3.9 2 1 0 3 3 3 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII65382.1 - 0.038 14.0 12.8 7.7 7.0 0.1 6.0 6 0 0 6 6 6 0 BNR/Asp-box repeat BNR_6 PF15899.5 KII65382.1 - 1.8 8.9 5.8 1.2 9.4 0.4 3.8 4 0 0 4 4 4 0 BNR-Asp box repeat Brix PF04427.18 KII65383.1 - 3.7e-14 53.3 0.1 3.7e-14 53.3 0.1 1.5 2 0 0 2 2 2 1 Brix domain RNB PF00773.19 KII65384.1 - 1e-36 127.0 0.1 1.6e-36 126.3 0.1 1.3 1 0 0 1 1 1 1 RNB domain AdoHcyase PF05221.17 KII65386.1 - 6.2e-37 127.3 0.0 8.2e-35 120.4 0.0 1.9 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase Wzz PF02706.15 KII65387.1 - 0.099 13.0 1.6 0.69 10.3 0.2 2.2 2 0 0 2 2 2 0 Chain length determinant protein DWNN PF08783.11 KII65388.1 - 0.059 13.7 2.1 0.81 10.0 0.0 2.9 2 0 0 2 2 2 0 DWNN domain HTH_32 PF13565.6 KII65390.1 - 6.7e-05 23.4 0.2 0.011 16.4 0.0 2.2 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 KII65390.1 - 0.00017 21.3 0.2 0.00049 19.8 0.0 1.9 2 1 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 KII65390.1 - 0.00076 19.5 0.1 0.0025 17.8 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix HTH_24 PF13412.6 KII65390.1 - 0.0021 17.6 0.5 0.041 13.5 0.0 2.8 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_Tnp_1 PF01527.20 KII65390.1 - 0.0035 17.6 0.1 0.0059 16.9 0.1 1.5 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.6 KII65390.1 - 0.011 15.8 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Phage_RpbA PF10789.9 KII65390.1 - 0.013 15.5 0.3 0.025 14.6 0.3 1.5 1 0 0 1 1 1 0 Phage RNA polymerase binding, RpbA RPA_C PF08784.11 KII65390.1 - 0.015 16.0 3.2 0.025 15.2 3.2 1.3 1 0 0 1 1 1 0 Replication protein A C terminal Rrf2 PF02082.20 KII65390.1 - 0.02 15.2 1.2 0.056 13.8 0.0 2.4 2 1 1 3 3 3 0 Transcriptional regulator DDE_3 PF13358.6 KII65391.1 - 4e-15 55.8 0.0 5.5e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.6 KII65392.1 - 4e-06 26.5 0.2 7.5e-06 25.6 0.1 1.5 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII65392.1 - 0.04 14.1 1.3 0.3 11.4 0.3 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KII65392.1 - 0.12 12.5 1.1 11 6.4 0.2 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat DDE_3 PF13358.6 KII65393.1 - 0.0012 18.6 3.0 0.029 14.1 0.4 3.3 3 1 0 3 3 3 1 DDE superfamily endonuclease Retrotrans_gag PF03732.17 KII65393.1 - 0.12 12.7 0.3 0.12 12.7 0.3 2.0 3 0 0 3 3 3 0 Retrotransposon gag protein Cytomega_US3 PF05963.11 KII65394.1 - 0.084 12.5 0.0 0.093 12.4 0.0 1.0 1 0 0 1 1 1 0 Cytomegalovirus US3 protein MLVIN_C PF18697.1 KII65395.1 - 0.0048 17.0 0.1 0.008 16.2 0.1 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Integrase_H2C2 PF17921.1 KII65398.1 - 9.8e-20 70.4 1.0 2e-19 69.4 1.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII65398.1 - 0.011 15.9 0.2 0.029 14.6 0.0 1.7 2 0 0 2 2 2 0 H2C2 zinc finger Atracotoxin PF05353.11 KII65400.1 - 0.093 12.8 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Delta Atracotoxin GDP_Man_Dehyd PF16363.5 KII65401.1 - 9.3e-59 199.5 0.0 1e-58 199.3 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KII65401.1 - 6.1e-18 65.2 0.0 8.6e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KII65402.1 - 7.5e-21 74.9 0.1 9.1e-21 74.6 0.1 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KII65402.1 - 5.1e-09 35.9 0.0 5.9e-09 35.7 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family HTH_29 PF13551.6 KII65403.1 - 2.3e-07 30.7 0.0 3.6e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 KII65403.1 - 2.2e-06 27.3 0.0 4.7e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 KII65403.1 - 1e-05 25.6 0.0 1.8e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 KII65403.1 - 4.9e-05 23.0 0.0 0.0013 18.4 0.0 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII65403.1 - 0.0012 18.8 0.1 0.0025 17.8 0.1 1.5 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.6 KII65403.1 - 0.063 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_11 PF08279.12 KII65403.1 - 0.064 13.2 0.2 0.17 11.9 0.2 1.7 1 0 0 1 1 1 0 HTH domain HTH_32 PF13565.6 KII65403.1 - 0.086 13.5 0.0 0.27 11.9 0.0 1.8 1 1 1 2 2 2 0 Homeodomain-like domain Rubredoxin_C PF18267.1 KII65403.1 - 0.24 11.3 1.0 8.4 6.4 0.0 2.6 2 0 0 2 2 2 0 Rubredoxin NAD+ reductase C-terminal domain CENP-B_N PF04218.13 KII65404.1 - 7e-05 22.4 0.2 0.00019 21.0 0.1 1.8 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_IclR PF09339.10 KII65404.1 - 0.0006 19.6 0.1 0.019 14.8 0.0 2.2 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_10 PF04967.12 KII65404.1 - 0.0018 18.0 0.0 0.42 10.4 0.0 2.3 2 0 0 2 2 2 2 HTH DNA binding domain HTH_3 PF01381.22 KII65404.1 - 0.0048 16.9 2.6 0.11 12.6 0.0 2.7 3 0 0 3 3 3 1 Helix-turn-helix HTH_Tnp_Tc5 PF03221.16 KII65404.1 - 0.0072 16.3 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 KII65404.1 - 0.0088 15.8 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_24 PF13412.6 KII65404.1 - 0.013 15.1 0.3 0.18 11.4 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 KII65404.1 - 0.021 14.7 0.1 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain HTH_38 PF13936.6 KII65404.1 - 0.039 13.7 0.3 0.086 12.6 0.1 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 KII65404.1 - 0.047 13.5 0.0 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain MFS_1 PF07690.16 KII65405.1 - 1.6e-33 116.1 28.2 9.8e-32 110.2 26.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4371 PF14291.6 KII65406.1 - 2.7e-12 46.8 0.1 2.7e-12 46.8 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 KII65406.1 - 2.4e-06 27.2 0.1 5.8e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Corazonin PF17308.2 KII65407.1 - 0.29 11.5 4.1 0.24 11.7 2.2 1.9 2 0 0 2 2 2 0 Pro-corazonin GvpG PF05120.12 KII65409.1 - 0.025 14.6 0.6 0.047 13.7 0.6 1.4 1 0 0 1 1 1 0 Gas vesicle protein G DASH_Spc19 PF08287.11 KII65409.1 - 0.041 13.8 5.7 0.064 13.2 5.7 1.3 1 0 0 1 1 1 0 Spc19 Nop52 PF05997.12 KII65410.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.4 1 1 0 1 1 1 0 Nucleolar protein,Nop52 SSFA2_C PF14723.6 KII65411.1 - 6.7 6.6 8.5 0.46 10.4 2.9 1.7 1 1 1 2 2 2 0 Sperm-specific antigen 2 C-terminus Glucos_trans_II PF14264.6 KII65412.1 - 0.057 12.8 0.3 7.7 5.8 0.4 2.0 2 0 0 2 2 2 0 Glucosyl transferase GtrII TMEM154 PF15102.6 KII65413.1 - 0.3 11.0 3.4 0.95 9.4 3.4 1.9 1 1 0 1 1 1 0 TMEM154 protein family Pkinase PF00069.25 KII65416.1 - 8.1e-71 238.5 0.1 1.8e-70 237.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII65416.1 - 5.4e-38 130.7 0.0 1.9e-37 129.0 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase POLO_box PF00659.18 KII65416.1 - 1.2e-33 115.1 0.7 6.1e-19 68.0 0.0 2.5 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 KII65416.1 - 1.1e-07 31.5 0.0 4.5e-05 22.9 0.0 2.5 1 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KII65416.1 - 0.013 14.3 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 KII65416.1 - 0.026 13.5 1.3 0.069 12.1 1.2 1.6 1 1 0 1 1 1 0 Haspin like kinase domain GRAM PF02893.20 KII65417.1 - 0.0007 19.5 1.1 0.011 15.6 1.0 2.4 1 1 0 1 1 1 1 GRAM domain DUF2661 PF10860.8 KII65417.1 - 0.19 11.9 3.7 0.085 13.0 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2661) EMP24_GP25L PF01105.24 KII65422.1 - 2.7e-23 82.9 2.0 2.9e-23 82.7 2.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2569 PF10754.9 KII65422.1 - 0.034 14.6 0.2 0.042 14.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) zf-LYAR PF08790.11 KII65423.1 - 0.13 12.2 0.1 0.3 11.0 0.1 1.6 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger Kelch_6 PF13964.6 KII65424.1 - 1.1e-23 82.6 23.1 1.7e-05 25.0 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KII65424.1 - 5.9e-20 70.6 17.9 9.7e-06 25.1 0.3 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII65424.1 - 1e-15 57.5 19.0 0.00066 19.6 0.0 5.7 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KII65424.1 - 1.4e-13 50.7 16.2 0.00049 20.3 0.0 6.6 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII65424.1 - 4.8e-12 45.6 14.1 0.015 15.3 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KII65424.1 - 1.4e-10 40.7 14.5 0.02 14.8 0.1 5.5 5 0 0 5 5 5 5 Kelch motif PSI PF01437.25 KII65425.1 - 0.07 13.7 2.4 0.11 13.1 2.4 1.4 1 1 0 1 1 1 0 Plexin repeat PSI_integrin PF17205.3 KII65425.1 - 0.23 11.2 4.0 0.38 10.5 4.0 1.5 1 1 0 1 1 1 0 Integrin plexin domain MLVIN_C PF18697.1 KII65426.1 - 0.0059 16.7 0.0 0.017 15.2 0.0 1.8 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RT_RNaseH PF17917.1 KII65427.1 - 3.3e-36 123.8 0.1 8.6e-35 119.2 0.1 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65427.1 - 1.2e-33 115.1 0.1 1.4e-32 111.7 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII65427.1 - 1.2e-05 25.3 0.1 3.1e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain KorB PF08535.10 KII65427.1 - 0.05 13.6 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 KorB domain RVT_1 PF00078.27 KII65428.1 - 0.0014 18.2 0.1 0.0043 16.6 0.1 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ldl_recept_a PF00057.18 KII65430.1 - 1.7e-10 40.9 26.0 2.7e-06 27.5 8.4 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A HTH_23 PF13384.6 KII65433.1 - 0.0015 18.2 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.6 KII65433.1 - 0.0063 16.3 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 KII65433.1 - 0.066 13.2 0.0 0.09 12.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_28 PF13518.6 KII65433.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Glycos_transf_2 PF00535.26 KII65434.1 - 6.3e-28 97.7 0.1 9e-28 97.2 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KII65434.1 - 0.0001 22.3 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Arabinose_trans PF04602.12 KII65434.1 - 0.042 12.7 0.4 0.058 12.2 0.4 1.1 1 0 0 1 1 1 0 Mycobacterial cell wall arabinan synthesis protein Glyco_tranf_2_2 PF10111.9 KII65434.1 - 0.056 12.9 0.1 0.087 12.3 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KII65434.1 - 0.14 12.7 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Pox_A14 PF05767.12 KII65434.1 - 0.19 11.9 0.9 0.39 10.9 0.9 1.5 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 PNTB_4TM PF12769.7 KII65435.1 - 0.0081 16.6 0.1 0.048 14.1 0.1 2.3 1 0 0 1 1 1 1 4TM region of pyridine nucleotide transhydrogenase, mitoch DUF4365 PF14280.6 KII65436.1 - 1.3e-14 54.3 0.1 2.7e-14 53.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4365) TPR_2 PF07719.17 KII65436.1 - 2.6e-13 49.0 9.1 1.2e-05 25.0 0.7 4.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KII65436.1 - 8.9e-11 41.3 6.0 2.6e-09 36.6 0.9 3.3 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 KII65436.1 - 9.8e-11 42.0 0.6 6.5e-06 26.6 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KII65436.1 - 3.2e-09 37.0 1.1 5.1e-07 29.9 0.1 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KII65436.1 - 7.8e-09 35.6 2.0 2.3e-05 24.8 0.0 4.1 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KII65436.1 - 1e-08 34.6 16.0 2.8e-06 26.9 0.1 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KII65436.1 - 2.3e-06 27.7 6.6 0.0066 16.7 0.7 3.7 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 Integrase_1 PF12835.7 KII65436.1 - 3.4e-05 24.0 0.1 7e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 Integrase TPR_17 PF13431.6 KII65436.1 - 0.00015 21.9 0.6 0.00015 21.9 0.6 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 KII65436.1 - 0.00032 20.8 0.7 0.012 15.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat ChAPs PF09295.10 KII65436.1 - 0.00035 19.7 2.3 0.11 11.5 0.2 2.6 3 0 0 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.8 KII65436.1 - 0.00036 19.6 2.1 0.00099 18.1 0.1 2.5 2 1 0 3 3 3 1 NMDA receptor-regulated protein 1 TPR_8 PF13181.6 KII65436.1 - 0.00044 20.2 15.3 0.0021 18.1 0.1 5.0 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 KII65436.1 - 0.0011 19.3 0.7 0.41 11.0 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KII65436.1 - 0.0014 19.3 0.0 0.0064 17.1 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KII65436.1 - 0.0018 18.2 0.0 8.4 6.7 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KII65436.1 - 0.028 14.3 2.1 7.7 6.5 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 KII65436.1 - 0.032 14.9 2.4 17 6.3 0.0 4.6 5 0 0 5 5 3 0 Tetratricopeptide repeat BTAD PF03704.17 KII65436.1 - 0.051 14.0 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial transcriptional activator domain SHNi-TPR PF10516.9 KII65436.1 - 0.11 12.0 0.6 2 7.9 0.0 3.2 3 0 0 3 3 3 0 SHNi-TPR DUF4326 PF14216.6 KII65437.1 - 3.1e-20 72.7 0.0 6e-20 71.8 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4326) DUF488 PF04343.13 KII65438.1 - 2.4e-25 89.5 0.1 2.8e-25 89.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF488 Rep_1 PF01446.17 KII65439.1 - 9.5e-16 58.0 3.6 6e-15 55.4 3.6 1.9 1 1 0 1 1 1 1 Replication protein Arylesterase PF01731.20 KII65443.1 - 0.069 13.4 0.5 0.069 13.4 0.5 1.6 2 0 0 2 2 2 0 Arylesterase MU117 PF15474.6 KII65444.1 - 0.056 14.2 0.5 0.089 13.6 0.5 1.3 1 0 0 1 1 1 0 Meiotically up-regulated gene family Tafi-CsgC PF10610.9 KII65445.1 - 0.11 12.7 0.0 0.48 10.6 0.0 2.1 1 1 1 2 2 2 0 Thin aggregative fimbriae synthesis protein FAM60A PF15396.6 KII65446.1 - 2.3e-06 27.7 3.7 5.1e-06 26.6 0.0 2.1 1 1 0 2 2 2 1 Protein Family FAM60A FAM60A PF15396.6 KII65447.1 - 0.00016 21.8 0.0 0.00025 21.1 0.0 1.5 1 0 0 1 1 1 1 Protein Family FAM60A MSA-2c PF12238.8 KII65447.1 - 0.12 12.4 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c Tox-HNH-HHH PF15637.6 KII65448.1 - 0.16 12.2 0.6 0.42 10.8 0.6 1.7 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif DUF2427 PF10348.9 KII65450.1 - 0.049 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) FAM60A PF15396.6 KII65451.1 - 6.7e-06 26.3 2.1 1.6e-05 25.0 0.1 2.0 2 0 0 2 2 2 1 Protein Family FAM60A DDE_3 PF13358.6 KII65454.1 - 2.1e-07 30.8 0.0 3.1e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Dynamin_M PF01031.20 KII65454.1 - 0.029 13.6 0.2 0.32 10.2 0.0 1.9 1 1 1 2 2 2 0 Dynamin central region Mei5_like PF17021.5 KII65455.1 - 0.0037 17.3 1.0 0.005 16.9 0.1 1.7 2 0 0 2 2 2 1 Putative double-strand recombination repair-like Dopey_N PF04118.14 KII65455.1 - 0.012 14.8 0.1 0.015 14.5 0.1 1.1 1 0 0 1 1 1 0 Dopey, N-terminal Pox_F15 PF04596.12 KII65455.1 - 0.021 14.6 0.1 0.039 13.7 0.1 1.4 1 1 0 1 1 1 0 Poxvirus protein F15 Peptidase_C1 PF00112.23 KII65456.1 - 7.6e-47 160.2 0.0 1.2e-46 159.5 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII65456.1 - 3.1e-06 27.5 2.6 7.7e-06 26.2 2.6 1.7 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Pox_polyA_pol_C PF12629.7 KII65458.1 - 0.0048 16.8 0.4 0.0053 16.6 0.4 1.1 1 0 0 1 1 1 1 Poxvirus poly(A) polymerase C-terminal domain WD40 PF00400.32 KII65459.1 - 9.3e-25 86.4 17.9 1.1e-06 29.3 0.2 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII65459.1 - 9.1e-17 61.2 0.8 0.045 14.1 0.0 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KII65459.1 - 1.1e-08 35.3 1.5 0.0006 19.7 0.1 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A DPPIV_N PF00930.21 KII65459.1 - 0.00068 18.5 0.6 0.52 9.0 0.1 3.1 2 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Coatomer_WDAD PF04053.14 KII65459.1 - 0.0031 16.6 1.3 1.8 7.5 0.0 3.1 1 1 1 3 3 3 1 Coatomer WD associated region Ge1_WD40 PF16529.5 KII65459.1 - 0.0034 16.4 0.2 4 6.3 0.0 4.2 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein TFIIIC_delta PF12657.7 KII65459.1 - 0.027 14.4 0.3 4.4 7.2 0.0 3.3 3 1 0 3 3 3 0 Transcription factor IIIC subunit delta N-term Arylsulfotran_2 PF14269.6 KII65459.1 - 0.031 13.6 0.2 0.061 12.7 0.2 1.5 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) RAB3GAP2_N PF14655.6 KII65459.1 - 0.039 13.2 0.0 0.38 10.0 0.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Gmad1 PF10647.9 KII65459.1 - 0.21 11.3 0.0 7.8 6.2 0.0 2.8 3 1 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain RT_RNaseH PF17917.1 KII65460.1 - 3.4e-34 117.3 0.0 1.1e-33 115.6 0.0 2.0 2 0 0 2 2 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65460.1 - 2.6e-33 114.0 0.0 6e-33 112.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65460.1 - 4.4e-24 85.2 0.1 1.2e-23 83.8 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII65460.1 - 1e-21 77.3 0.0 2.4e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65460.1 - 2.2e-18 66.1 0.7 1.7e-17 63.2 0.0 2.8 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII65460.1 - 6.1e-06 26.7 0.0 1.2e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-H2C2 PF09337.10 KII65460.1 - 0.00018 21.7 0.1 0.00059 20.0 0.1 2.0 1 0 0 1 1 1 1 H2C2 zinc finger Asp_protease_2 PF13650.6 KII65460.1 - 0.0012 19.4 0.1 0.004 17.8 0.0 1.8 2 0 0 2 2 1 1 Aspartyl protease rve_3 PF13683.6 KII65460.1 - 0.031 14.1 0.1 0.089 12.6 0.1 1.8 1 0 0 1 1 1 0 Integrase core domain RVP PF00077.20 KII65460.1 - 0.059 13.7 0.4 0.19 12.0 0.2 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease Ribosomal_L36e PF01158.18 KII65460.1 - 0.12 12.6 0.0 0.37 11.0 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein L36e zinc_ribbon_2 PF13240.6 KII65460.1 - 1.7 8.5 4.8 30 4.5 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zf-CCHC PF00098.23 KII65460.1 - 2.3 8.5 7.8 2.6 8.3 1.9 2.8 2 0 0 2 2 2 0 Zinc knuckle Pkinase PF00069.25 KII65461.1 - 1.5e-57 195.0 5.5 8.1e-57 192.6 5.5 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII65461.1 - 5.9e-36 124.1 1.0 7.5e-36 123.7 1.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KII65461.1 - 0.0074 15.7 1.0 0.013 14.9 1.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KII65461.1 - 0.016 14.8 0.5 1.8 8.2 0.1 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 rve PF00665.26 KII65463.1 - 2.6e-11 43.8 0.0 3.8e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65463.1 - 0.021 14.6 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Shugoshin_C PF07557.11 KII65464.1 - 0.033 14.0 0.1 0.056 13.3 0.1 1.4 1 0 0 1 1 1 0 Shugoshin C terminus GCV_T PF01571.21 KII65465.1 - 0.0049 16.3 0.0 0.0053 16.2 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain RT_RNaseH_2 PF17919.1 KII65466.1 - 1.9e-09 37.5 0.0 6.2e-09 35.8 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65466.1 - 3.9e-08 33.5 0.0 9.6e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII65466.1 - 6.3e-06 26.4 0.0 1.3e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 KII65466.1 - 0.0034 16.9 0.2 1.1 8.7 0.0 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 KII65466.1 - 0.014 15.2 0.1 1.4 8.6 0.0 2.3 1 1 1 2 2 2 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII65466.1 - 0.067 13.8 0.2 1.3 9.6 0.0 2.8 1 1 2 3 3 3 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII65466.1 - 0.12 12.1 0.0 5.4 6.8 0.0 2.3 1 1 1 2 2 2 0 Aspartyl protease Integrase_H2C2 PF17921.1 KII65466.1 - 0.38 10.9 1.6 0.55 10.4 0.1 2.1 3 0 0 3 3 3 0 Integrase zinc binding domain RVT_1 PF00078.27 KII65467.1 - 3.9e-12 46.2 0.1 7.1e-12 45.3 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII65467.1 - 0.011 16.3 0.0 0.087 13.4 0.0 2.3 1 1 1 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII65467.1 - 0.054 14.1 0.0 0.17 12.6 0.0 1.8 1 1 1 2 2 2 0 Aspartyl protease rve PF00665.26 KII65469.1 - 5.8e-16 58.8 0.0 1.6e-08 34.7 0.0 3.5 2 1 0 2 2 2 2 Integrase core domain Integrase_H2C2 PF17921.1 KII65469.1 - 0.0019 18.2 2.6 0.17 12.0 0.1 3.1 3 0 0 3 3 3 2 Integrase zinc binding domain MscL PF01741.18 KII65469.1 - 0.052 13.8 0.2 0.11 12.8 0.2 1.5 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL DdrB PF12747.7 KII65470.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 DdrB-like protein Kelch_3 PF13415.6 KII65471.1 - 1.2e-12 47.8 1.8 0.0054 17.0 0.2 4.9 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KII65471.1 - 5.3e-12 45.6 12.5 0.0081 16.4 0.1 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII65471.1 - 4e-10 39.5 4.6 0.00025 20.9 0.1 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KII65471.1 - 3.4e-08 32.9 16.0 0.02 14.5 0.4 5.5 6 1 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII65471.1 - 3.2e-06 27.0 19.7 0.0022 18.0 0.3 6.1 5 2 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII65471.1 - 1.3 9.1 7.7 5.2 7.2 0.0 4.6 6 0 0 6 6 6 0 Kelch motif Kelch_1 PF01344.25 KII65473.1 - 4.8e-12 45.3 5.5 0.00028 20.4 0.1 4.3 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 KII65473.1 - 1.3e-11 44.3 10.8 0.002 18.4 0.1 5.4 5 1 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 KII65473.1 - 1.5e-10 40.9 10.8 2.8e-05 24.0 0.1 5.1 4 3 2 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII65473.1 - 5.1e-09 36.2 4.9 0.0083 16.4 0.0 4.6 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII65473.1 - 0.0009 19.1 3.1 1.7 8.8 0.1 3.7 4 0 0 4 4 4 2 Kelch motif DZR PF12773.7 KII65473.1 - 0.031 14.3 0.0 0.15 12.1 0.0 2.1 1 1 1 2 2 2 0 Double zinc ribbon Kelch_5 PF13854.6 KII65473.1 - 0.053 13.5 0.3 0.33 11.0 0.1 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 KII65474.1 - 1.1e-16 60.4 17.0 2.8e-06 27.4 0.3 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KII65474.1 - 1.8e-15 56.2 12.4 1.2e-06 28.0 0.2 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII65474.1 - 1e-08 35.2 6.0 0.016 15.5 0.0 6.4 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KII65474.1 - 2e-08 34.1 22.8 0.0019 18.2 0.2 6.4 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KII65474.1 - 1.3e-06 28.1 12.3 0.0043 17.0 0.2 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 KII65474.1 - 0.01 15.8 16.1 0.077 13.0 0.2 5.2 5 1 0 5 5 5 0 Kelch motif Kelch_6 PF13964.6 KII65476.1 - 2.2e-18 65.8 15.4 9.1e-06 25.8 0.3 6.5 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KII65476.1 - 2e-16 59.7 10.9 0.00033 20.6 0.1 6.2 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII65476.1 - 7.3e-15 54.3 9.0 6.4e-05 22.5 0.0 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII65476.1 - 3.6e-12 46.3 5.5 0.0027 17.9 0.0 6.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII65476.1 - 8.5e-07 28.7 12.4 0.038 14.0 0.1 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII65476.1 - 3.8e-06 26.8 12.2 0.11 12.6 0.1 5.5 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 KII65477.1 - 1.9e-18 65.7 18.2 1.4e-06 27.8 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KII65477.1 - 8.6e-17 60.8 19.5 4.3e-07 30.0 0.2 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII65477.1 - 1.8e-15 56.7 15.1 0.00026 20.9 0.1 6.2 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII65477.1 - 1.4e-11 44.3 14.0 0.0077 16.5 0.1 5.9 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KII65477.1 - 4.2e-11 42.3 13.8 0.069 13.2 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 KII65477.1 - 6.1e-10 38.9 13.4 0.0004 20.3 0.2 5.3 5 0 0 5 5 5 4 Kelch motif GCR PF02155.15 KII65477.1 - 0.19 10.7 0.1 0.28 10.2 0.1 1.1 1 0 0 1 1 1 0 Glucocorticoid receptor YmzC PF14157.6 KII65478.1 - 0.044 13.9 0.1 0.076 13.1 0.1 1.4 1 0 0 1 1 1 0 YmzC-like protein DDE_3 PF13358.6 KII65478.1 - 0.067 12.9 0.0 0.081 12.7 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease PH_2 PF08458.10 KII65478.1 - 0.096 13.0 0.6 0.7 10.3 0.1 2.0 1 1 1 2 2 2 0 Plant pleckstrin homology-like region Bcr-Abl_Oligo PF09036.10 KII65479.1 - 0.022 14.8 0.1 0.95 9.5 0.0 2.3 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain CHDCT2 PF08074.11 KII65480.1 - 0.016 15.4 0.0 0.016 15.4 0.0 1.1 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain DUF1098 PF06497.11 KII65480.1 - 0.12 12.9 0.1 0.48 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1098) DUF1759 PF03564.15 KII65481.1 - 0.09 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) DUF1314 PF07013.11 KII65482.1 - 0.067 13.1 0.0 0.097 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) NTNH_C PF08470.10 KII65484.1 - 0.074 12.9 6.4 0.81 9.6 6.4 2.2 1 1 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal KRE1 PF17056.5 KII65485.1 - 0.14 11.9 1.0 0.77 9.5 0.3 2.1 1 1 1 2 2 2 0 Killer toxin-resistance protein 1 Serglycin PF04360.12 KII65485.1 - 1.8 8.5 6.4 14 5.6 6.4 2.0 1 1 0 1 1 1 0 Serglycin DUF4489 PF14879.6 KII65486.1 - 0.0016 18.6 0.1 0.0022 18.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4489) Vpu PF00558.19 KII65487.1 - 0.093 12.5 2.3 1.2 9.0 0.2 2.1 2 0 0 2 2 2 0 Vpu protein SANT_DAMP1_like PF16282.5 KII65489.1 - 0.068 13.4 0.2 0.25 11.6 0.1 1.9 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Glyco_trans_4_5 PF16994.5 KII65493.1 - 0.12 12.0 0.0 5.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Glycosyl-transferase family 4 ERAP1_C PF11838.8 KII65494.1 - 1.4e-18 67.6 0.0 1.6e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain IstB_IS21_ATP PF08483.11 KII65494.1 - 0.001 18.9 0.4 0.0017 18.2 0.4 1.4 1 0 0 1 1 1 1 IstB-like ATP binding N-terminal VPS11_C PF12451.8 KII65494.1 - 0.013 15.8 0.2 0.031 14.5 0.2 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal DUF1336 PF07059.12 KII65494.1 - 0.065 13.3 0.0 0.13 12.3 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1336) Ala_racemase_C PF00842.21 KII65497.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Alanine racemase, C-terminal domain UPF0004 PF00919.20 KII65498.1 - 0.13 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein family UPF0004 PP2C PF00481.21 KII65501.1 - 1.2e-67 228.3 0.0 1.7e-67 227.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.13 KII65501.1 - 1.7e-10 41.2 0.2 3.5e-10 40.2 0.2 1.6 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.6 KII65501.1 - 0.00014 21.6 0.0 0.00051 19.7 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C SelP_N PF04592.14 KII65502.1 - 0.009 15.4 0.1 0.011 15.1 0.1 1.1 1 0 0 1 1 1 1 Selenoprotein P, N terminal region CopD PF05425.13 KII65503.1 - 0.084 13.3 0.8 0.14 12.5 0.8 1.2 1 0 0 1 1 1 0 Copper resistance protein D MFS_1 PF07690.16 KII65505.1 - 3.5e-05 22.9 0.5 4.2e-05 22.6 0.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4040 PF13244.6 KII65505.1 - 0.013 15.7 0.4 0.03 14.5 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) KLRAQ PF10205.9 KII65506.1 - 0.0075 16.5 3.1 0.012 15.8 3.1 1.3 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein NYD-SP28 PF14772.6 KII65506.1 - 0.022 14.8 2.4 0.034 14.2 2.4 1.3 1 0 0 1 1 1 0 Sperm tail DDE_3 PF13358.6 KII65507.1 - 4.2e-06 26.6 0.0 4.9e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH PF17917.1 KII65508.1 - 4.2e-35 120.2 0.0 8.8e-35 119.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65508.1 - 9.7e-35 118.6 0.0 2.1e-34 117.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII65508.1 - 9.3e-21 73.7 0.1 2.1e-20 72.5 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII65508.1 - 2.6e-20 72.9 0.1 7.3e-20 71.4 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII65508.1 - 2.1e-18 66.7 0.0 8.9e-18 64.6 0.0 2.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65508.1 - 0.0012 18.6 0.0 0.0031 17.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII65508.1 - 0.0043 17.1 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Spore_coat_CotO PF14153.6 KII65508.1 - 0.22 11.4 8.0 0.21 11.5 6.1 1.8 2 0 0 2 2 2 0 Spore coat protein CotO RT_RNaseH_2 PF17919.1 KII65509.1 - 0.0008 19.4 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65509.1 - 0.02 15.2 0.0 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65510.1 - 3.8e-07 29.9 0.0 3.9e-05 23.3 0.0 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Metallophos PF00149.28 KII65511.1 - 1.8e-05 25.3 0.1 2.1e-05 25.1 0.1 1.0 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RT_RNaseH_2 PF17919.1 KII65512.1 - 1.5e-34 118.0 0.0 8e-34 115.7 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65512.1 - 2.5e-34 118.7 0.1 5.5e-34 117.6 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII65512.1 - 1.1e-32 112.4 0.0 8.9e-32 109.5 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII65512.1 - 2.2e-20 73.0 0.0 7e-20 71.4 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65512.1 - 2.4e-18 66.0 0.4 6.7e-18 64.6 0.4 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII65512.1 - 4.5e-05 23.6 0.1 0.00073 19.7 0.0 2.6 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII65512.1 - 0.00016 21.4 0.2 0.0023 17.7 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.14 KII65512.1 - 0.019 15.1 0.0 0.039 14.1 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) DUF2014 PF09427.10 KII65512.1 - 0.06 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) zf-MIZ PF02891.20 KII65513.1 - 8.5e-19 67.1 3.3 1.5e-18 66.2 3.3 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KII65513.1 - 5e-07 29.4 1.8 5e-07 29.4 1.8 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit PINIT PF14324.6 KII65513.1 - 1.5e-05 25.4 0.1 2.9e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 PINIT domain zf-C3HC4_2 PF13923.6 KII65513.1 - 0.023 14.5 8.4 0.12 12.3 5.7 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KII65513.1 - 0.18 11.8 6.6 0.24 11.4 0.9 3.0 2 1 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KII65513.1 - 1.5 9.1 7.5 1.9 8.7 5.5 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KII65513.1 - 3.8 7.5 6.0 1.2 9.0 2.7 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CPP1-like PF11833.8 KII65514.1 - 0.061 13.0 0.1 0.076 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like 2TM PF13239.6 KII65515.1 - 1.1 9.7 7.4 2 8.8 7.4 1.4 1 0 0 1 1 1 0 2TM domain MHB PF16525.5 KII65516.1 - 0.0038 17.4 0.1 0.43 10.9 0.0 3.7 3 1 1 4 4 4 1 Haemophore, haem-binding CRAL_TRIO_2 PF13716.6 KII65516.1 - 0.17 12.1 4.6 16 5.6 0.2 3.6 3 0 0 3 3 3 0 Divergent CRAL/TRIO domain DUF4108 PF13390.6 KII65516.1 - 8.8 6.2 12.6 10 6.1 7.8 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF4108) MIP-T3 PF10243.9 KII65517.1 - 0.096 12.7 0.3 0.18 11.8 0.3 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CH-like domain DUF2634 PF10934.8 KII65519.1 - 0.034 14.2 1.0 0.1 12.7 1.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2634) Pro-NT_NN PF07421.11 KII65519.1 - 0.044 14.0 0.1 0.069 13.4 0.1 1.3 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor Rad4 PF03835.15 KII65519.1 - 0.12 12.0 0.2 0.19 11.4 0.2 1.3 1 0 0 1 1 1 0 Rad4 transglutaminase-like domain EMP24_GP25L PF01105.24 KII65522.1 - 7.9e-21 74.8 4.3 9e-21 74.6 4.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Lig_C PF18330.1 KII65522.1 - 0.0086 16.1 0.1 0.014 15.4 0.1 1.3 1 0 0 1 1 1 1 Ligase Pab1020 C-terminal region NTF2 PF02136.20 KII65522.1 - 0.016 15.7 0.1 0.03 14.9 0.1 1.4 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain Peptidase_M19 PF01244.21 KII65522.1 - 0.055 12.6 0.3 0.074 12.2 0.3 1.1 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) Acetyltransf_11 PF13720.6 KII65522.1 - 0.072 13.6 0.3 7.3 7.1 0.0 2.3 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 SARS_3b PF12383.8 KII65523.1 - 0.023 14.8 0.1 0.025 14.7 0.1 1.2 1 0 0 1 1 1 0 Severe acute respiratory syndrome coronavirus 3b protein Integrase_H2C2 PF17921.1 KII65524.1 - 3.2e-05 24.0 0.0 5.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII65532.1 - 4.3e-12 46.3 0.0 6.7e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65532.1 - 3.1e-06 26.9 0.0 9.7e-06 25.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_1_2 PF13586.6 KII65532.1 - 0.043 14.2 0.0 0.29 11.5 0.0 2.3 2 0 0 2 2 2 0 Transposase DDE domain Agenet PF05641.12 KII65532.1 - 0.063 13.8 0.1 0.15 12.6 0.1 1.6 1 0 0 1 1 1 0 Agenet domain gag-asp_proteas PF13975.6 KII65533.1 - 0.0061 17.1 0.0 0.011 16.3 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII65533.1 - 0.17 12.5 0.0 0.27 11.9 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease Ntox34 PF15606.6 KII65535.1 - 0.06 13.5 1.5 1 9.5 0.3 2.1 2 0 0 2 2 2 0 Bacterial toxin 34 RT_RNaseH PF17917.1 KII65536.1 - 1.2e-15 57.7 0.2 1.8e-15 57.1 0.2 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65536.1 - 5.8e-07 29.5 0.3 8.7e-07 28.9 0.3 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF406 PF04175.12 KII65539.1 - 0.076 13.5 0.0 0.25 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF406) Lebercilin PF15619.6 KII65544.1 - 0.02 14.6 1.5 0.026 14.2 1.5 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF737 PF05300.11 KII65544.1 - 0.041 14.2 0.7 0.052 13.9 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) PCO_ADO PF07847.12 KII65546.1 - 9.1e-20 71.0 0.0 1.2e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 PCO_ADO SF3A3 PF16837.5 KII65547.1 - 9.8e-21 74.1 2.5 9.8e-21 74.1 2.5 2.7 3 0 0 3 3 3 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 KII65547.1 - 5.5e-10 38.9 1.0 5.5e-10 38.9 1.0 2.5 2 0 0 2 2 2 1 Splicing factor SF3a60 binding domain Telomere_Sde2_2 PF13297.6 KII65547.1 - 9.4e-10 38.0 0.1 3e-09 36.4 0.1 1.9 2 0 0 2 2 2 1 Telomere stability C-terminal CorA PF01544.18 KII65547.1 - 0.13 11.6 5.0 3.3 6.9 5.0 2.2 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein RNase_PH PF01138.21 KII65548.1 - 5.5e-07 30.1 0.0 9e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KII65548.1 - 0.023 14.7 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 SNAP PF14938.6 KII65549.1 - 1.1e-08 34.9 0.3 1.3e-08 34.6 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII65549.1 - 0.029 14.6 0.7 0.029 14.6 0.7 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 KII65549.1 - 0.31 10.7 2.1 5.5 6.7 0.0 2.9 1 1 0 2 2 2 0 26S proteasome subunit RPN7 NSF PF02071.20 KII65549.1 - 1 10.4 4.3 3.3 8.9 0.0 3.8 3 1 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat RepL PF05732.11 KII65553.1 - 0.041 13.3 0.2 0.071 12.5 0.2 1.4 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) STI1 PF17830.1 KII65554.1 - 0.032 14.2 0.0 0.063 13.2 0.0 1.5 1 0 0 1 1 1 0 STI1 domain ABC2_membrane_2 PF12679.7 KII65556.1 - 0.12 11.6 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF898 PF05987.13 KII65560.1 - 0.0041 16.2 1.7 0.0046 16.1 1.7 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) BPD_transp_1 PF00528.22 KII65560.1 - 0.0067 16.2 2.0 0.0088 15.8 2.0 1.1 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF1980 PF09323.10 KII65560.1 - 0.01 15.7 2.0 0.013 15.5 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Yip1 PF04893.17 KII65560.1 - 0.013 15.2 1.7 0.018 14.8 1.7 1.2 1 0 0 1 1 1 0 Yip1 domain DUF3377 PF11857.8 KII65560.1 - 0.045 13.7 4.7 1.5 8.8 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF4083 PF13314.6 KII65560.1 - 0.056 13.4 2.6 0.056 13.4 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) COX2_TM PF02790.15 KII65560.1 - 0.11 12.6 6.4 0.15 12.2 1.4 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF3267 PF11667.8 KII65560.1 - 1.8 8.9 14.5 0.5 10.7 2.8 2.1 1 1 1 2 2 2 0 Putative zincin peptidase Sigma_reg_N PF13800.6 KII65560.1 - 2.4 8.5 6.6 0.85 9.9 1.0 2.2 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF5383 PF17355.2 KII65560.1 - 3.6 8.0 4.8 2.3 8.6 0.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5383) TadF PF16964.5 KII65560.1 - 7.1 6.3 6.4 11 5.7 0.6 2.1 2 0 0 2 2 2 0 Putative tight adherence pilin protein F AA_permease_2 PF13520.6 KII65561.1 - 2.6e-45 155.0 53.4 3.1e-45 154.8 53.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII65561.1 - 4.7e-22 78.2 45.7 6.3e-22 77.8 45.7 1.1 1 0 0 1 1 1 1 Amino acid permease Cytochrom_C_asm PF01578.20 KII65561.1 - 4.5 7.0 21.4 0.015 15.1 7.8 3.1 3 1 0 3 3 3 0 Cytochrome C assembly protein Annexin PF00191.20 KII65563.1 - 6.3e-15 55.0 4.1 9.7e-05 22.4 0.1 3.4 3 0 0 3 3 3 3 Annexin EGF PF00008.27 KII65564.1 - 0.04 14.2 1.2 0.04 14.2 1.2 4.0 3 1 0 3 3 3 0 EGF-like domain EGF_2 PF07974.13 KII65564.1 - 3 8.3 31.7 0.72 10.3 2.3 2.9 3 0 0 3 3 3 0 EGF-like domain MAP65_ASE1 PF03999.12 KII65565.1 - 4.6e-59 200.7 42.6 6.6e-59 200.1 40.1 1.8 1 1 1 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) GAPES2 PF17156.4 KII65567.1 - 0.053 13.3 0.0 0.065 13.0 0.0 1.1 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain Asp_protease_2 PF13650.6 KII65570.1 - 0.0019 18.8 0.0 0.0049 17.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII65570.1 - 0.005 16.9 2.8 0.005 16.9 2.8 2.5 2 0 0 2 2 2 1 Zinc knuckle gag-asp_proteas PF13975.6 KII65570.1 - 0.028 15.0 0.0 0.073 13.6 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.17 KII65570.1 - 0.096 13.0 0.0 2.7 8.3 0.0 2.5 2 0 0 2 2 2 0 Retrotransposon gag protein NOB1_Zn_bind PF08772.11 KII65570.1 - 0.15 12.2 4.5 0.33 11.1 4.5 1.5 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zf-CCHC_4 PF14392.6 KII65570.1 - 0.17 11.6 7.7 0.25 11.1 1.4 2.7 2 0 0 2 2 2 0 Zinc knuckle MCM PF00493.23 KII65571.1 - 2e-75 252.7 0.5 2.7e-52 177.1 0.4 2.3 1 1 1 2 2 2 2 MCM P-loop domain MCM_lid PF17855.1 KII65571.1 - 5.4e-28 97.2 1.4 1.3e-27 96.1 1.4 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 KII65571.1 - 1.5e-22 79.9 2.7 2.7e-22 79.0 2.7 1.4 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_OB PF17207.3 KII65571.1 - 2.9e-22 78.8 0.6 5.6e-22 77.9 0.6 1.5 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 KII65571.1 - 3.1e-08 33.3 0.0 7.2e-08 32.1 0.0 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KII65571.1 - 0.005 16.6 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 KII65571.1 - 0.01 15.7 0.0 0.03 14.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KII65571.1 - 0.073 13.1 0.1 2.6 8.1 0.0 3.1 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 KII65571.1 - 0.1 13.3 0.2 0.38 11.4 0.1 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal MCM_N PF14551.6 KII65572.1 - 3.5e-15 56.5 0.1 4.8e-15 56.0 0.1 1.2 1 0 0 1 1 1 1 MCM N-terminal domain DDE_3 PF13358.6 KII65573.1 - 0.00097 18.9 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII65573.1 - 0.0012 19.0 0.2 0.0028 17.9 0.2 1.6 1 0 0 1 1 1 1 Transposase HTH_5 PF01022.20 KII65573.1 - 0.0027 17.6 0.2 0.012 15.5 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_23 PF13384.6 KII65573.1 - 0.0051 16.6 0.7 0.24 11.3 0.2 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 KII65573.1 - 0.11 12.6 0.3 0.24 11.5 0.3 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain RT_RNaseH PF17917.1 KII65574.1 - 1.3e-36 125.1 0.0 2.9e-36 123.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65574.1 - 4.2e-36 123.0 0.0 1e-35 121.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65574.1 - 2.1e-20 73.2 0.0 1.1e-19 70.9 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII65574.1 - 5e-19 68.6 0.0 2.1e-18 66.7 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65574.1 - 1.1e-15 57.5 0.2 1.1e-15 57.5 0.2 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII65574.1 - 0.0049 16.6 0.0 0.015 15.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 KII65574.1 - 0.0086 16.7 0.0 0.024 15.3 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease zf-H2C2 PF09337.10 KII65574.1 - 0.011 15.9 0.0 0.04 14.2 0.0 2.0 1 0 0 1 1 1 0 H2C2 zinc finger DNA_pol_viral_C PF00336.18 KII65574.1 - 0.023 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain gag-asp_proteas PF13975.6 KII65574.1 - 0.14 12.8 0.0 0.36 11.4 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII65574.1 - 1.3 9.2 13.4 0.019 15.0 2.8 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII65574.1 - 2.3 8.0 7.7 0.93 9.3 1.4 2.6 2 0 0 2 2 2 0 Zinc knuckle DDE_Tnp_IS1595 PF12762.7 KII65575.1 - 0.0001 22.3 0.1 0.00017 21.7 0.1 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Tho2 PF11262.8 KII65576.1 - 3.3e-60 203.8 12.9 6.1e-60 203.0 12.9 1.4 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 KII65576.1 - 9.4e-44 150.1 14.0 2.7e-28 99.0 0.2 4.5 3 1 1 4 4 4 3 THO complex subunit 2 N-terminus Thoc2 PF11732.8 KII65576.1 - 7.3e-17 61.2 1.5 1.8e-16 59.9 0.2 2.4 2 0 0 2 2 2 1 Transcription- and export-related complex subunit MULE PF10551.9 KII65578.1 - 6e-10 39.4 0.0 9.9e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 MULE transposase domain JAB PF01398.21 KII65579.1 - 1.4e-05 25.1 1.0 0.00087 19.3 1.0 2.7 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DPCD PF14913.6 KII65580.1 - 1.8e-50 170.9 3.7 4.7e-50 169.6 3.7 1.7 1 0 0 1 1 1 1 DPCD protein family Integrase_H2C2 PF17921.1 KII65580.1 - 6.4e-19 67.8 0.4 6.4e-19 67.8 0.4 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 KII65580.1 - 2.9e-17 62.9 0.6 9e-16 58.1 0.0 3.4 4 0 0 4 4 4 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII65580.1 - 5e-16 59.0 0.1 2.6e-14 53.5 0.0 3.3 3 0 0 3 3 3 1 Integrase core domain RT_RNaseH_2 PF17919.1 KII65580.1 - 8.8e-09 35.3 0.2 3.7e-07 30.1 0.0 2.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 KII65580.1 - 2.3e-05 24.1 0.2 8.7e-05 22.2 0.2 2.1 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 KII65580.1 - 0.0022 18.0 2.3 0.006 16.6 2.3 1.8 1 0 0 1 1 1 1 Zinc knuckle Cas_Cas02710 PF09670.10 KII65580.1 - 0.095 11.5 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) zf-H2C2 PF09337.10 KII65580.1 - 0.1 12.8 0.0 0.41 10.9 0.0 2.1 1 0 0 1 1 1 0 H2C2 zinc finger DUF993 PF06187.11 KII65580.1 - 0.2 10.5 0.0 0.32 9.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF993) JAB PF01398.21 KII65581.1 - 3.6e-23 81.8 0.1 6.4e-23 81.0 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 KII65581.1 - 0.00049 20.5 0.0 0.0012 19.2 0.0 1.7 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 KII65581.1 - 0.0018 18.1 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain KIP1 PF07765.12 KII65581.1 - 0.046 13.8 0.2 2.5 8.3 0.0 2.5 2 0 0 2 2 2 0 KIP1-like protein PALP PF00291.25 KII65583.1 - 1.6e-35 122.9 0.0 1.7e-35 122.8 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DFP PF04127.15 KII65583.1 - 0.0044 16.9 0.0 0.0062 16.4 0.0 1.2 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Integrase_H2C2 PF17921.1 KII65586.1 - 1.9e-05 24.7 0.3 4.5e-05 23.5 0.0 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain DUF2748 PF10871.8 KII65587.1 - 0.049 12.2 0.1 0.058 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) NitrOD5 PF11537.8 KII65588.1 - 0.061 13.5 0.1 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 Nitrosopumilus output domain 5 Kelch_6 PF13964.6 KII65589.1 - 3.5e-20 71.5 12.1 8.6e-05 22.7 0.3 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII65589.1 - 1.5e-12 47.3 13.1 0.00045 20.2 0.0 6.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII65589.1 - 2e-12 46.5 12.9 0.00033 20.2 0.0 6.4 6 1 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII65589.1 - 5.3e-12 45.7 10.4 0.016 15.5 0.0 5.9 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII65589.1 - 2.5e-05 24.1 6.0 3.3 7.8 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Ntox25 PF15530.6 KII65589.1 - 0.013 15.7 0.1 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 Bacterial toxin 25 FBA_3 PF08268.12 KII65589.1 - 0.023 14.6 0.3 0.09 12.7 0.0 2.1 2 1 1 3 3 3 0 F-box associated domain Kelch_5 PF13854.6 KII65589.1 - 0.12 12.4 15.2 5.4 7.1 0.4 5.5 6 0 0 6 6 6 0 Kelch motif RT_RNaseH_2 PF17919.1 KII65591.1 - 6.8e-27 93.4 0.0 9.3e-27 93.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65591.1 - 2.1e-23 82.6 0.0 2.5e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DDE_Tnp_IS1595 PF12762.7 KII65593.1 - 1.7e-18 67.1 0.0 2.6e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_ribbon_recom PF13408.6 KII65593.1 - 0.094 13.2 6.4 0.28 11.7 6.4 1.7 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain CRAL_TRIO_N PF03765.15 KII65593.1 - 0.098 12.9 0.2 0.2 11.8 0.2 1.5 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain NolV PF06635.12 KII65596.1 - 0.037 13.4 0.0 0.062 12.7 0.0 1.3 1 1 0 1 1 1 0 Nodulation protein NolV Tetraspanin PF00335.20 KII65597.1 - 0.0099 15.6 26.9 0.052 13.3 26.9 2.2 1 1 0 1 1 1 1 Tetraspanin family RED_C PF07807.11 KII65598.1 - 8.5e-07 29.4 14.9 29 5.2 0.1 8.5 1 1 8 9 9 9 7 RED-like protein C-terminal region DUF4573 PF15140.6 KII65598.1 - 7.6e-05 22.6 37.2 0.00095 19.0 14.1 3.3 2 2 1 3 3 3 2 Domain of unknown function (DUF4573) Cullin PF00888.22 KII65599.1 - 5.1e-45 154.2 24.0 6.7e-45 153.8 24.0 1.1 1 0 0 1 1 1 1 Cullin family MPS-4 PF17523.2 KII65599.1 - 0.024 14.7 0.5 0.24 11.5 0.1 2.5 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 OATP PF03137.20 KII65600.1 - 5.1e-36 124.1 16.5 6e-36 123.8 16.5 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KII65600.1 - 2.6e-15 56.2 6.2 3.8e-15 55.7 6.2 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily 7TMR-DISM_7TM PF07695.11 KII65600.1 - 0.0013 18.7 7.4 0.0013 18.7 7.4 2.3 2 1 0 2 2 2 1 7TM diverse intracellular signalling CrgA PF06781.12 KII65600.1 - 4 7.6 12.3 13 5.9 5.1 3.2 2 1 1 3 3 3 0 Cell division protein CrgA COX7a PF02238.15 KII65600.1 - 4.4 7.8 8.4 5 7.6 0.0 3.9 3 1 1 4 4 4 0 Cytochrome c oxidase subunit VII Tfb2 PF03849.14 KII65601.1 - 3e-52 177.8 7.2 4.1e-52 177.3 7.2 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 KII65601.1 - 1.7e-23 82.8 0.3 4.3e-23 81.5 0.3 1.7 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 KII65601.1 - 0.0025 18.0 0.1 0.0073 16.5 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain UQ_con PF00179.26 KII65603.1 - 2.6e-30 104.9 0.0 1.9e-28 98.9 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme Serpin PF00079.20 KII65604.1 - 1.7e-14 53.9 0.1 1.9e-14 53.8 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII65605.1 - 1.1e-18 67.7 0.0 1.3e-18 67.5 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII65606.1 - 2.6e-09 36.9 0.0 2.8e-09 36.7 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-HIT PF04438.16 KII65607.1 - 3.8e-05 23.5 12.8 3.8e-05 23.5 12.8 2.2 2 0 0 2 2 2 1 HIT zinc finger Astacin PF01400.24 KII65608.1 - 6.4e-46 156.4 1.4 9.4e-46 155.8 1.4 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 KII65608.1 - 2.2 8.1 5.5 5.6 6.8 0.1 2.4 1 1 1 2 2 2 0 Matrixin A1_Propeptide PF07966.12 KII65610.1 - 0.019 14.8 0.2 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 A1 Propeptide HTH_Tnp_Mu_1 PF02316.16 KII65610.1 - 0.076 13.2 0.0 0.094 12.9 0.0 1.1 1 0 0 1 1 1 0 Mu DNA-binding domain rve PF00665.26 KII65614.1 - 0.01 16.0 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain rve_3 PF13683.6 KII65614.1 - 0.024 14.4 0.1 0.072 12.9 0.0 1.9 2 0 0 2 2 2 0 Integrase core domain Kelch_6 PF13964.6 KII65616.1 - 7.1e-12 45.2 10.5 0.0054 17.0 0.2 6.1 5 1 1 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII65616.1 - 2.1e-05 24.6 4.4 0.0015 18.8 0.0 3.5 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII65616.1 - 4.7e-05 22.9 16.5 0.021 14.4 0.1 6.0 6 1 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 KII65616.1 - 0.0001 22.1 6.5 0.0024 17.8 0.1 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 KII65616.1 - 0.00013 21.9 7.0 0.002 18.1 0.1 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain CENP-B_dimeris PF09026.10 KII65616.1 - 0.0041 17.5 5.2 0.01 16.2 5.2 1.6 1 0 0 1 1 1 1 Centromere protein B dimerisation domain FBA_1 PF07734.13 KII65616.1 - 0.0076 16.2 0.2 0.058 13.3 0.0 2.2 1 1 1 2 2 2 1 F-box associated Kelch_5 PF13854.6 KII65616.1 - 0.056 13.5 9.1 0.3 11.1 0.0 4.2 5 0 0 5 5 5 0 Kelch motif NOA36 PF06524.12 KII65616.1 - 0.6 9.4 4.2 0.87 8.8 4.2 1.2 1 0 0 1 1 1 0 NOA36 protein Kelch_3 PF13415.6 KII65617.1 - 0.00076 19.7 0.0 0.0013 18.9 0.0 1.4 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KII65617.1 - 0.0026 18.0 0.3 0.23 11.8 0.0 2.4 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII65617.1 - 0.0067 16.4 0.2 0.034 14.2 0.1 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KII65618.1 - 3e-19 68.6 2.4 4.3e-07 30.0 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII65618.1 - 4.9e-11 42.6 2.4 0.0019 18.4 0.1 3.7 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII65618.1 - 8.2e-07 28.5 7.3 0.0038 16.8 0.3 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 KII65618.1 - 1.2e-05 25.2 7.3 0.048 13.7 0.0 3.9 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII65618.1 - 0.0022 17.9 2.7 0.86 9.7 0.0 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 KII65618.1 - 0.018 15.0 3.7 5 7.3 0.0 3.5 3 1 0 3 3 3 0 Kelch motif DUF2795 PF11387.8 KII65618.1 - 0.21 11.8 0.0 0.46 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) DUF4834 PF16118.5 KII65623.1 - 5.1 8.1 8.8 1.2 10.2 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Kelch_6 PF13964.6 KII65625.1 - 1.7e-07 31.3 9.9 0.8 10.1 0.1 5.5 4 2 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 KII65625.1 - 1.6e-06 28.2 12.3 0.031 14.6 0.0 5.5 5 2 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII65625.1 - 0.00013 21.8 2.4 0.65 10.1 0.0 4.9 4 1 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 KII65625.1 - 0.0016 18.4 11.4 3.1 7.9 0.0 5.6 6 1 1 7 7 7 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII65625.1 - 0.079 13.0 0.2 1.1 9.3 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 KII65625.1 - 0.39 10.4 14.0 4.1 7.1 0.0 5.5 6 1 1 7 7 7 0 Kelch motif Tropomyosin PF00261.20 KII65626.1 - 0.049 13.0 4.4 0.077 12.3 4.4 1.3 1 0 0 1 1 1 0 Tropomyosin Retrotrans_gag PF03732.17 KII65627.1 - 0.015 15.6 0.5 0.029 14.6 0.3 1.6 1 1 1 2 2 2 0 Retrotransposon gag protein MLVIN_C PF18697.1 KII65629.1 - 0.024 14.7 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain AT_hook PF02178.19 KII65629.1 - 0.98 9.5 7.8 2 8.6 7.8 1.6 1 0 0 1 1 1 0 AT hook motif NPV_P10 PF05531.12 KII65631.1 - 0.083 13.4 10.2 4 8.0 2.0 3.9 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 KII65631.1 - 0.17 12.2 18.4 0.053 13.7 9.8 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding cwf21 PF08312.12 KII65631.1 - 0.25 11.6 9.4 0.039 14.1 4.3 2.3 2 1 0 2 2 2 0 cwf21 domain Tropomyosin_1 PF12718.7 KII65631.1 - 0.32 11.2 22.1 1.5 8.9 11.8 2.9 2 1 0 2 2 2 0 Tropomyosin like DUF2680 PF10925.8 KII65631.1 - 0.61 10.1 4.3 0.44 10.6 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) HalX PF08663.10 KII65631.1 - 0.7 10.2 6.6 0.86 10.0 0.1 3.3 3 0 0 3 3 3 0 HalX domain Pox_A_type_inc PF04508.12 KII65631.1 - 0.78 9.7 17.6 0.57 10.1 0.5 4.4 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat Cob_adeno_trans PF01923.18 KII65631.1 - 0.96 9.6 5.4 18 5.4 0.0 2.7 2 1 0 2 2 2 0 Cobalamin adenosyltransferase KELK PF15796.5 KII65631.1 - 2.1 8.9 12.1 3.4 8.2 5.1 3.1 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DivIC PF04977.15 KII65631.1 - 2.1 8.2 18.0 0.96 9.3 0.1 4.3 3 1 1 4 4 4 0 Septum formation initiator MtrG PF04210.13 KII65631.1 - 2.5 8.0 5.6 1 9.3 0.1 2.6 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G FlaC_arch PF05377.11 KII65631.1 - 4.5 7.7 10.6 26 5.3 0.1 3.8 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) CtIP_N PF10482.9 KII65631.1 - 7.1 6.7 23.3 15 5.6 4.0 3.4 2 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain PmrD PF11183.8 KII65632.1 - 0.098 12.8 0.1 1.5 9.0 0.0 2.3 1 1 1 2 2 2 0 Polymyxin resistance protein PmrD zf-UBR PF02207.20 KII65634.1 - 7.9e-12 45.2 20.5 7.9e-12 45.2 20.5 2.4 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 KII65634.1 - 0.033 14.0 0.0 0.1 12.4 0.0 1.9 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS RVT_1 PF00078.27 KII65639.1 - 1.4e-06 28.0 0.0 2e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sortilin-Vps10 PF15902.5 KII65640.1 - 6.9e-10 38.3 0.5 7.8e-08 31.5 0.0 2.9 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII65640.1 - 1.5e-05 25.4 0.2 3.3e-05 24.3 0.2 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal AhpC-TSA PF00578.21 KII65640.1 - 0.11 12.5 0.2 0.31 11.0 0.0 1.9 2 0 0 2 2 2 0 AhpC/TSA family Staphostatin_B PF09023.10 KII65640.1 - 0.35 10.9 6.0 4 7.5 0.1 4.1 3 2 2 5 5 5 0 Staphostatin B Sortilin-Vps10 PF15902.5 KII65641.1 - 1.1e-07 31.1 6.0 0.00034 19.5 0.0 2.4 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII65641.1 - 1e-06 28.8 21.6 2.9e-06 27.4 9.8 2.9 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF5074 PF16819.5 KII65641.1 - 0.13 12.3 2.5 10 6.2 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5074) CRS1_YhbY PF01985.21 KII65645.1 - 0.18 12.0 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 CRS1 / YhbY (CRM) domain MFS_1 PF07690.16 KII65646.1 - 1.1e-36 126.6 44.7 5.2e-35 121.0 25.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KII65646.1 - 2.2e-05 23.9 0.8 2.2e-05 23.9 0.8 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Phage_holin_5_2 PF16079.5 KII65646.1 - 0.1 12.9 0.5 0.1 12.9 0.5 3.6 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V DUF4538 PF15061.6 KII65646.1 - 0.19 11.5 2.4 0.64 9.8 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Phage_holin_2_3 PF16080.5 KII65646.1 - 0.83 9.5 4.1 8.7 6.2 1.0 2.8 2 0 0 2 2 2 0 Bacteriophage holin family HP1 CH PF00307.31 KII65648.1 - 3.4e-44 149.5 0.4 1.2e-20 73.7 0.0 3.4 3 0 0 3 3 3 2 Calponin homology (CH) domain Spectrin PF00435.21 KII65648.1 - 2e-27 95.7 16.8 9.2e-08 32.5 0.4 4.6 4 0 0 4 4 4 4 Spectrin repeat EFhand_Ca_insen PF08726.10 KII65648.1 - 1.4e-13 50.7 0.0 7.9e-13 48.3 0.0 2.4 2 0 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_7 PF13499.6 KII65648.1 - 8.9e-05 22.9 0.9 0.0006 20.2 0.9 2.6 1 0 0 1 1 1 1 EF-hand domain pair CAMSAP_CH PF11971.8 KII65648.1 - 0.00014 21.6 0.0 0.01 15.7 0.0 2.8 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_1 PF00036.32 KII65648.1 - 0.00088 18.7 2.2 0.0047 16.4 0.0 3.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KII65648.1 - 0.039 13.9 6.9 5.1 7.3 0.0 3.9 3 0 0 3 3 3 0 EF-hand domain GLTP PF08718.11 KII65648.1 - 0.054 13.8 0.2 1.3 9.3 0.2 3.0 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) AAA_12 PF13087.6 KII65648.1 - 0.06 13.0 1.5 0.14 11.7 0.3 2.1 2 0 0 2 2 2 0 AAA domain DASH_Dam1 PF08653.10 KII65648.1 - 5.1 7.0 6.0 14 5.6 0.0 4.7 4 2 2 6 6 6 0 DASH complex subunit Dam1 Ribosomal_L2_C PF03947.18 KII65649.1 - 0.052 13.7 0.1 0.06 13.6 0.1 1.1 1 0 0 1 1 1 0 Ribosomal Proteins L2, C-terminal domain CH PF00307.31 KII65650.1 - 7.5e-35 119.4 0.0 4.1e-16 59.1 0.0 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KII65650.1 - 5.5e-07 29.3 0.0 0.0019 18.0 0.0 2.6 2 1 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 KII65650.1 - 0.0019 18.3 0.0 0.021 15.0 0.0 2.1 2 0 0 2 2 2 1 CH-like domain in sperm protein PAPS_reduct PF01507.19 KII65651.1 - 1.5e-20 73.9 0.1 1.3e-17 64.4 0.1 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family YhfH PF14149.6 KII65651.1 - 0.29 11.1 0.9 2.5 8.1 0.6 2.4 2 0 0 2 2 2 0 YhfH-like protein PAP_assoc PF03828.19 KII65652.1 - 0.026 14.7 0.7 0.33 11.2 0.7 2.8 1 1 0 1 1 1 0 Cid1 family poly A polymerase CD99L2 PF12301.8 KII65653.1 - 0.22 11.8 0.8 0.32 11.3 0.8 1.2 1 0 0 1 1 1 0 CD99 antigen like protein 2 GCP_N_terminal PF17681.1 KII65656.1 - 2.4e-24 86.5 0.0 3.1e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 KII65657.1 - 1.6e-35 123.1 10.3 6e-24 85.1 9.6 2.0 1 1 1 2 2 2 2 Gamma tubulin complex component C-terminal PUL PF08324.11 KII65657.1 - 0.005 16.1 0.0 0.0079 15.5 0.0 1.3 1 0 0 1 1 1 1 PUL domain I_LWEQ PF01608.17 KII65658.1 - 2e-16 60.6 0.1 2e-16 60.6 0.1 4.0 3 1 1 4 4 4 1 I/LWEQ domain KASH_CCD PF14662.6 KII65658.1 - 0.00085 19.2 20.2 0.00085 19.2 20.2 2.4 3 1 0 3 3 3 1 Coiled-coil region of CCDC155 or KASH Fas_alpha_ACP PF18325.1 KII65658.1 - 0.018 15.4 1.3 0.043 14.1 1.3 1.6 1 0 0 1 1 1 0 Fatty acid synthase subunit alpha Acyl carrier domain DUF4250 PF14056.6 KII65658.1 - 0.026 14.5 1.0 1.7 8.7 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) DUF4808 PF16066.5 KII65658.1 - 0.092 13.3 0.4 0.24 12.0 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) PKcGMP_CC PF16808.5 KII65658.1 - 0.14 12.0 10.9 2.4 8.1 1.6 4.2 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF484 PF04340.12 KII65658.1 - 0.21 11.3 10.7 0.3 10.7 4.2 2.9 2 1 1 3 3 3 0 Protein of unknown function, DUF484 bZIP_1 PF00170.21 KII65658.1 - 0.45 10.6 17.1 6.8 6.9 0.2 4.6 2 1 2 4 4 4 0 bZIP transcription factor ATG16 PF08614.11 KII65658.1 - 0.73 10.0 24.3 1.3 9.2 18.8 3.3 2 2 0 2 2 2 0 Autophagy protein 16 (ATG16) Atg14 PF10186.9 KII65658.1 - 0.84 8.7 15.2 1.6 7.7 13.4 2.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TSC22 PF01166.18 KII65658.1 - 0.94 9.8 15.6 4.6 7.6 0.9 5.1 3 2 1 4 4 4 0 TSC-22/dip/bun family Ima1_N PF09779.9 KII65658.1 - 1.8 9.5 8.0 0.4 11.5 3.6 2.2 2 0 0 2 2 2 0 Ima1 N-terminal domain DUF1843 PF08898.10 KII65658.1 - 2.9 8.4 5.0 36 4.9 0.4 3.7 4 0 0 4 4 3 0 Domain of unknown function (DUF1843) DUF4407 PF14362.6 KII65658.1 - 3.2 7.0 15.1 3.5 6.9 10.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) Ferritin-like PF12902.7 KII65658.1 - 3.5 7.4 10.7 0.18 11.7 1.5 3.1 3 1 0 3 3 3 0 Ferritin-like Nif11 PF07862.11 KII65658.1 - 4.4 7.7 6.6 11 6.4 0.2 4.3 3 1 0 3 3 3 0 Nif11 domain DUF641 PF04859.12 KII65658.1 - 6.7 7.1 14.1 0.85 10.0 4.1 3.1 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) PRCC PF10253.9 KII65659.1 - 4.5e-10 40.7 0.1 5.6e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting DUF4915 PF16261.5 KII65660.1 - 0.063 12.5 0.0 0.063 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4915) LIDHydrolase PF10230.9 KII65660.1 - 0.15 11.6 1.6 2.5 7.6 0.0 2.0 1 1 0 2 2 2 0 Lipid-droplet associated hydrolase Asp1 PF16993.5 KII65665.1 - 0.051 12.8 0.0 0.058 12.6 0.0 1.0 1 0 0 1 1 1 0 Accessory Sec system protein Asp1 CBM_48 PF02922.18 KII65666.1 - 0.00013 22.2 0.6 0.00026 21.3 0.0 1.8 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 KII65667.1 - 6.9e-19 68.1 0.2 1.9e-18 66.7 0.1 1.8 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Clathrin PF00637.20 KII65668.1 - 2.5e-148 487.8 47.4 3.2e-27 95.2 5.4 8.3 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 KII65668.1 - 8.4e-14 51.2 0.1 4.3e-13 49.0 0.1 2.4 1 0 0 1 1 1 1 Clathrin-H-link Coatomer_WDAD PF04053.14 KII65668.1 - 1.2e-06 27.9 3.9 0.015 14.3 0.1 3.9 4 0 0 4 4 4 2 Coatomer WD associated region ANAPC3 PF12895.7 KII65668.1 - 2.8e-06 27.5 10.6 0.032 14.5 0.4 6.5 5 1 0 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 Clathrin_propel PF01394.20 KII65668.1 - 1.7e-05 24.9 0.6 0.48 10.8 0.0 4.7 5 0 0 5 5 5 2 Clathrin propeller repeat TPR_7 PF13176.6 KII65668.1 - 0.00034 20.4 0.4 6.3 7.1 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 KII65668.1 - 0.00053 20.4 0.0 16 6.1 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 KII65668.1 - 0.021 14.6 7.9 11 6.0 0.0 7.0 9 0 0 9 9 9 0 Tetratricopeptide repeat DUF5049 PF16468.5 KII65668.1 - 0.28 11.1 2.1 22 5.0 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF5049) zf-U1 PF06220.12 KII65669.1 - 3.3e-21 74.8 4.4 4.7e-21 74.3 4.4 1.2 1 0 0 1 1 1 1 U1 zinc finger zf-met PF12874.7 KII65669.1 - 2.6 8.6 6.2 16 6.0 6.2 2.0 1 1 0 1 1 1 0 Zinc-finger of C2H2 type LIM PF00412.22 KII65670.1 - 3.2e-24 84.9 53.8 2.9e-10 40.2 13.7 3.1 3 0 0 3 3 3 3 LIM domain DUF4476 PF14771.6 KII65670.1 - 0.05 13.9 6.6 0.05 13.9 0.4 3.1 1 1 2 4 4 4 0 Domain of unknown function (DUF4476) Sgf11 PF08209.11 KII65670.1 - 0.75 9.4 0.0 0.75 9.4 0.0 6.2 6 0 0 6 6 6 0 Sgf11 (transcriptional regulation protein) PDZ PF00595.24 KII65671.1 - 1.7e-10 41.1 0.1 5.1e-10 39.6 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII65671.1 - 5.3e-07 29.4 0.0 1.3e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII65671.1 - 4.4e-05 23.7 0.0 0.00014 22.1 0.0 1.8 1 0 0 1 1 1 1 PDZ domain HTH_Tnp_Tc5 PF03221.16 KII65672.1 - 5e-10 39.3 0.1 1.8e-09 37.4 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_3 PF01381.22 KII65672.1 - 0.029 14.4 0.1 0.056 13.5 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix MULE PF10551.9 KII65673.1 - 0.0011 19.4 0.1 0.0023 18.3 0.1 1.6 1 0 0 1 1 1 1 MULE transposase domain PDZ PF00595.24 KII65674.1 - 5.3e-10 39.5 0.2 9.3e-10 38.7 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII65674.1 - 0.00031 20.5 0.0 0.00049 19.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII65674.1 - 0.0004 20.7 0.1 0.00078 19.7 0.1 1.5 1 0 0 1 1 1 1 PDZ domain Ctr PF04145.15 KII65674.1 - 0.12 12.9 0.3 0.16 12.5 0.3 1.3 1 1 0 1 1 1 0 Ctr copper transporter family PurA PF04845.13 KII65675.1 - 6.9e-09 35.3 0.2 0.0008 18.8 0.0 2.1 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein PurA PF04845.13 KII65676.1 - 0.00011 21.6 0.1 0.00014 21.3 0.1 1.1 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein Homeodomain PF00046.29 KII65678.1 - 1.1e-21 76.5 2.0 2.4e-21 75.3 2.0 1.6 1 0 0 1 1 1 1 Homeodomain SatD PF16264.5 KII65678.1 - 0.055 13.1 0.1 0.086 12.4 0.1 1.2 1 0 0 1 1 1 0 SatD family (SatD) Rad21_Rec8_N PF04825.13 KII65679.1 - 2.8e-09 37.1 0.1 7.2e-09 35.8 0.1 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein F-box-like_2 PF13013.6 KII65679.1 - 0.045 13.7 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 F-box-like domain TPR_1 PF00515.28 KII65680.1 - 1.4e-09 37.4 3.2 3.5e-05 23.4 0.2 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KII65680.1 - 7.1e-09 35.1 2.2 0.00012 21.9 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII65680.1 - 1.9e-07 30.8 2.4 0.00021 21.3 0.1 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KII65680.1 - 6e-07 29.4 1.7 0.051 14.0 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KII65680.1 - 0.00031 20.4 1.3 0.004 16.8 0.1 2.7 2 1 1 3 3 3 2 TPR repeat ChAPs PF09295.10 KII65680.1 - 0.0012 18.0 0.3 0.0022 17.0 0.3 1.5 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) GEP5 PF17053.5 KII65680.1 - 0.031 14.1 0.7 0.095 12.5 0.7 1.8 2 0 0 2 2 2 0 Genetic interactor of prohibitin 5 TPR_7 PF13176.6 KII65680.1 - 0.064 13.3 1.9 9.3 6.5 0.1 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KII65680.1 - 0.079 13.3 0.4 1.4 9.3 0.1 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat Tk-SP_N-pro PF18237.1 KII65680.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Tk-SP N-propeptide domain Ribosomal_S18 PF01084.20 KII65681.1 - 0.00014 22.0 0.0 0.0003 21.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 RSRP PF17069.5 KII65683.1 - 0.014 15.0 31.4 0.017 14.7 31.4 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Yippee-Mis18 PF03226.14 KII65684.1 - 9.1e-11 41.9 0.7 1.1e-10 41.6 0.7 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Intron_maturas2 PF01348.21 KII65684.1 - 0.26 11.2 0.1 0.26 11.2 0.1 1.4 2 0 0 2 2 2 0 Type II intron maturase FRG1 PF06229.12 KII65685.1 - 2.5e-40 138.2 0.2 2.5e-40 138.2 0.2 1.5 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 KII65685.1 - 8.2e-13 48.5 0.9 1.2e-11 44.7 0.8 2.2 1 1 1 2 2 2 2 Fascin domain Bac_surface_Ag PF01103.23 KII65686.1 - 1.2e-32 113.7 9.0 1.6e-32 113.3 9.0 1.1 1 0 0 1 1 1 1 Surface antigen Thioredoxin_8 PF13905.6 KII65688.1 - 0.11 12.8 0.1 0.22 11.8 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like Clr5 PF14420.6 KII65688.1 - 0.12 12.6 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Clr5 domain JAB PF01398.21 KII65689.1 - 4e-05 23.6 0.0 6.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ribosomal_S9 PF00380.19 KII65690.1 - 4.2e-36 124.1 0.0 5.4e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Sortilin_C PF15901.5 KII65692.1 - 2.6e-17 63.7 7.1 3.8e-17 63.1 7.1 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII65692.1 - 3.4e-05 22.8 0.0 5.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII65692.1 - 0.071 13.1 0.1 12 6.4 0.0 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat ProRS-C_1 PF09180.11 KII65692.1 - 0.11 12.7 0.5 0.2 11.9 0.5 1.4 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal ABC_tran PF00005.27 KII65693.1 - 2.1e-26 93.1 0.0 3.1e-25 89.3 0.0 2.1 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KII65693.1 - 0.029 14.2 0.6 0.56 10.0 0.1 2.5 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 KII65693.1 - 0.051 13.2 0.0 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 KII65693.1 - 0.092 12.2 0.1 0.4 10.1 0.1 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KII65693.1 - 0.096 12.6 0.1 0.33 10.9 0.1 1.9 1 1 0 1 1 1 0 RsgA GTPase ABC2_membrane PF01061.24 KII65694.1 - 8.5e-44 149.5 23.8 8.5e-44 149.5 23.8 1.8 2 0 0 2 2 2 1 ABC-2 type transporter DUF1440 PF07274.12 KII65694.1 - 0.44 10.9 3.6 0.41 11.0 0.2 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1440) Myc_target_1 PF15179.6 KII65694.1 - 0.78 9.6 2.7 4.1 7.3 0.1 2.4 2 0 0 2 2 2 0 Myc target protein 1 Amidase PF01425.21 KII65695.1 - 2.1e-40 139.1 0.5 2.4e-40 138.9 0.5 1.0 1 0 0 1 1 1 1 Amidase Amidase PF01425.21 KII65696.1 - 8.2e-10 38.2 0.0 9.4e-10 38.0 0.0 1.0 1 0 0 1 1 1 1 Amidase MULE PF10551.9 KII65697.1 - 6.3e-07 29.7 0.0 1.1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 MULE transposase domain Amidase PF01425.21 KII65699.1 - 4.1e-29 101.9 0.4 4.6e-29 101.7 0.4 1.0 1 0 0 1 1 1 1 Amidase Amidase PF01425.21 KII65700.1 - 0.099 11.6 0.0 0.17 10.8 0.0 1.5 1 1 0 1 1 1 0 Amidase BCAS2 PF05700.11 KII65701.1 - 2.3e-28 99.3 0.5 2.6e-28 99.1 0.5 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) UDPGP PF01704.18 KII65702.1 - 3.5e-155 516.7 1.5 4.7e-155 516.3 1.5 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase CAP PF00188.26 KII65703.1 - 1.5e-53 181.0 7.8 1.7e-16 61.2 0.2 4.3 4 0 0 4 4 4 4 Cysteine-rich secretory protein family Glyco_hydro_30C PF17189.4 KII65703.1 - 0.094 12.9 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain DDE_Tnp_IS1595 PF12762.7 KII65705.1 - 2.5e-16 60.1 0.0 5.1e-16 59.0 0.0 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII65705.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease zf-trcl PF13451.6 KII65706.1 - 0.069 13.1 0.0 0.069 13.1 0.0 1.9 2 0 0 2 2 2 0 Probable zinc-ribbon domain Amidase PF01425.21 KII65707.1 - 1.8e-08 33.8 0.0 2.1e-08 33.6 0.0 1.0 1 0 0 1 1 1 1 Amidase Amidase PF01425.21 KII65708.1 - 3.4e-06 26.3 0.0 4.7e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Amidase DUF799 PF05643.11 KII65708.1 - 0.024 14.2 0.0 0.035 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative bacterial lipoprotein (DUF799) Amidase PF01425.21 KII65709.1 - 7.5e-39 133.9 0.7 7.8e-39 133.9 0.7 1.0 1 0 0 1 1 1 1 Amidase Amidase PF01425.21 KII65710.1 - 3.9e-08 32.7 0.0 4.4e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Amidase rve PF00665.26 KII65711.1 - 7.3e-17 61.7 0.0 1.8e-16 60.4 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII65711.1 - 6.9e-05 22.6 0.0 0.00015 21.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Tymo_45kd_70kd PF03251.13 KII65711.1 - 0.056 12.4 0.1 0.071 12.0 0.1 1.1 1 0 0 1 1 1 0 Tymovirus 45/70Kd protein RT_RNaseH_2 PF17919.1 KII65712.1 - 1.4e-35 121.3 0.0 9.3e-35 118.7 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65712.1 - 2e-35 121.3 0.0 7.5e-35 119.4 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65712.1 - 7.4e-24 84.5 0.0 2e-23 83.1 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII65712.1 - 1.9e-18 66.3 1.4 1.9e-18 66.3 1.4 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII65712.1 - 0.00015 21.9 3.3 0.0009 19.4 0.1 3.1 3 0 0 3 3 3 1 H2C2 zinc finger 2-oxoacid_dh PF00198.23 KII65713.1 - 3.4e-78 262.3 1.5 4.2e-78 262.0 1.5 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KII65713.1 - 7.7e-19 67.3 0.3 1.6e-18 66.3 0.3 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 KII65713.1 - 4.4e-06 26.6 1.6 0.0013 18.7 0.1 2.8 2 1 1 3 3 3 2 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.6 KII65713.1 - 2.1e-05 24.3 0.3 0.00066 19.4 0.0 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.19 KII65713.1 - 0.00081 19.3 1.5 0.0041 17.0 0.3 2.2 1 1 1 2 2 2 1 Glycine cleavage H-protein HlyD_D23 PF16576.5 KII65713.1 - 0.014 14.7 0.1 0.026 13.8 0.1 1.5 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Med20 PF08612.11 KII65717.1 - 0.00015 21.2 0.0 0.00031 20.2 0.0 1.7 1 1 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex MULE PF10551.9 KII65718.1 - 0.0085 16.5 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain zf-NF-X1 PF01422.17 KII65721.1 - 6.1e-05 23.0 29.2 0.00025 21.1 8.7 14.6 14 2 1 15 15 15 7 NF-X1 type zinc finger DDE_3 PF13358.6 KII65722.1 - 1.1e-10 41.5 0.1 1.6e-10 41.0 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease PET122 PF05476.11 KII65722.1 - 0.01 15.2 0.0 0.013 14.8 0.0 1.1 1 0 0 1 1 1 0 PET122 bZIP_2 PF07716.15 KII65723.1 - 1.7e-08 34.4 10.3 2.9e-08 33.7 10.3 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 KII65723.1 - 5.8e-07 29.5 10.8 9.1e-07 28.9 10.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor DUF3450 PF11932.8 KII65723.1 - 0.00025 20.4 0.8 0.00035 20.0 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) CSG2 PF16965.5 KII65723.1 - 0.00051 19.1 0.7 0.014 14.4 0.1 2.1 2 0 0 2 2 2 2 Ceramide synthase regulator DDE_Tnp_IS1595 PF12762.7 KII65724.1 - 3.9e-06 26.9 0.0 4.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_Tnp_IS1595 PF12760.7 KII65724.1 - 0.036 14.1 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DEAD PF00270.29 KII65725.1 - 1.1e-42 145.8 0.2 1.6e-42 145.2 0.2 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII65725.1 - 9.2e-32 109.7 0.0 1.6e-30 105.7 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 KII65725.1 - 6.7e-05 22.7 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 KII65725.1 - 0.00013 22.0 0.0 0.00032 20.8 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_25 PF13481.6 KII65725.1 - 0.0014 18.2 0.0 0.0029 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain SWI2_SNF2 PF18766.1 KII65725.1 - 0.0039 16.9 0.5 0.032 13.9 0.0 2.1 2 0 0 2 2 2 1 SWI2/SNF2 ATPase Helicase_RecD PF05127.14 KII65725.1 - 0.023 14.5 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 Helicase ERCC3_RAD25_C PF16203.5 KII65725.1 - 0.045 13.0 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 KII65725.1 - 0.069 13.4 0.5 0.27 11.5 0.5 2.0 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 KII65725.1 - 0.081 12.4 0.6 0.22 10.9 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein TniB PF05621.11 KII65725.1 - 0.081 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein UvrD-helicase PF00580.21 KII65725.1 - 0.13 11.8 0.5 0.27 10.7 0.5 1.3 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain CMS1 PF14617.6 KII65725.1 - 0.16 11.3 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DDE_3 PF13358.6 KII65726.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease S-AdoMet_synt_C PF02773.16 KII65727.1 - 2.5e-61 205.7 0.0 5e-61 204.7 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 KII65727.1 - 3.5e-42 143.5 0.0 7.4e-42 142.4 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 KII65727.1 - 1.6e-41 140.9 0.6 3.1e-41 140.1 0.6 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain Oxysterol_BP PF01237.18 KII65728.1 - 4.4e-114 381.2 0.0 5.3e-114 380.9 0.0 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein FYVE PF01363.21 KII65729.1 - 1.3e-11 44.4 3.9 1.3e-11 44.4 3.9 2.0 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.16 KII65729.1 - 0.0021 18.2 1.8 0.0044 17.2 1.8 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger IBR PF01485.21 KII65729.1 - 0.013 15.8 9.5 0.013 15.7 4.9 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_9 PF16293.5 KII65729.1 - 0.04 13.8 0.1 0.097 12.5 0.1 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 KII65729.1 - 0.42 11.6 0.5 0.42 11.6 0.5 3.4 2 1 1 3 3 3 0 C2H2-type zinc finger IF-2B PF01008.17 KII65730.1 - 3.9e-41 141.1 0.0 4.3e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF5085 PF16895.5 KII65730.1 - 0.11 12.8 0.3 7.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5085) YycI PF09648.10 KII65730.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 YycH protein LRR_6 PF13516.6 KII65733.1 - 3e-14 51.8 21.4 0.0025 17.8 0.1 8.6 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 KII65733.1 - 0.00011 22.5 12.9 0.064 13.7 0.0 6.4 5 2 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KII65733.1 - 1.1 10.0 6.8 1.1e+02 4.0 0.2 5.4 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_8 PF13855.6 KII65733.1 - 1.5 8.7 16.7 7.5 6.4 0.6 7.1 7 2 0 7 7 7 0 Leucine rich repeat Mucin PF01456.17 KII65734.1 - 0.0036 17.3 13.0 0.0062 16.5 13.0 1.5 1 0 0 1 1 1 1 Mucin-like glycoprotein TMEM154 PF15102.6 KII65734.1 - 0.023 14.6 11.7 0.062 13.2 10.9 2.2 1 1 0 1 1 1 0 TMEM154 protein family BPD_transp_1 PF00528.22 KII65734.1 - 0.047 13.4 0.2 0.067 12.9 0.2 1.1 1 0 0 1 1 1 0 Binding-protein-dependent transport system inner membrane component Ldl_recept_a PF00057.18 KII65736.1 - 7.5e-23 80.5 59.8 1e-10 41.6 16.7 3.9 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A Methyltransf_15 PF09445.10 KII65737.1 - 0.14 11.7 2.9 0.63 9.6 2.9 2.1 1 1 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Ldl_recept_a PF00057.18 KII65739.1 - 3.2e-08 33.7 29.8 7e-05 23.0 11.0 2.9 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 KII65739.1 - 1.7 8.4 9.9 2.9 7.7 9.9 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Sortilin-Vps10 PF15902.5 KII65741.1 - 0.00044 19.2 0.5 0.00051 18.9 0.5 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, DDE_3 PF13358.6 KII65746.1 - 4.7e-05 23.2 0.0 0.00011 22.0 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Soyouz_module PF14313.6 KII65746.1 - 3.2 7.6 6.1 6.9 6.5 6.1 1.5 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) SSP160 PF06933.11 KII65746.1 - 5.5 5.1 6.9 7.7 4.6 6.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Peroxin-3 PF04882.12 KII65750.1 - 0.0031 16.6 2.2 0.0031 16.6 2.2 1.1 1 0 0 1 1 1 1 Peroxin-3 Orf78 PF06024.12 KII65750.1 - 0.082 13.2 0.2 0.22 11.8 0.0 1.7 2 0 0 2 2 2 0 Orf78 (ac78) Orf78 PF06024.12 KII65751.1 - 0.033 14.5 0.3 0.071 13.4 0.3 1.6 1 1 0 1 1 1 0 Orf78 (ac78) DUF2714 PF10896.8 KII65751.1 - 0.044 13.8 1.3 0.056 13.5 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2714) Chordopox_A13L PF05961.11 KII65753.1 - 0.031 14.5 0.0 0.042 14.1 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DUF5305 PF17231.2 KII65754.1 - 0.0083 15.5 0.4 0.01 15.3 0.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Adeno_hexon_C PF03678.14 KII65754.1 - 0.024 14.1 0.2 0.028 13.9 0.2 1.1 1 0 0 1 1 1 0 Hexon, adenovirus major coat protein, C-terminal domain DUF3902 PF13042.6 KII65754.1 - 0.079 12.5 1.5 0.1 12.2 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3902) CENP-B_dimeris PF09026.10 KII65755.1 - 0.0052 17.2 0.6 0.0069 16.8 0.6 1.2 1 0 0 1 1 1 1 Centromere protein B dimerisation domain MSG PF02349.15 KII65755.1 - 0.29 11.3 8.0 6.5 7.0 0.5 2.2 1 1 0 1 1 1 0 Major surface glycoprotein RT_RNaseH_2 PF17919.1 KII65756.1 - 4.7e-10 39.4 0.0 7e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65756.1 - 1.8e-08 34.6 0.0 2.6e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF2678 PF10856.8 KII65759.1 - 0.005 16.8 0.8 0.0073 16.2 0.6 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2678) LapA_dom PF06305.11 KII65759.1 - 0.083 12.7 1.4 0.16 11.8 1.4 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF4501 PF14946.6 KII65759.1 - 0.2 11.7 0.2 0.27 11.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) rve PF00665.26 KII65760.1 - 3.3e-09 37.0 0.0 7.1e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65760.1 - 0.027 14.6 0.1 0.072 13.2 0.1 1.8 1 0 0 1 1 1 0 Integrase zinc binding domain DUF5366 PF17328.2 KII65762.1 - 0.062 13.4 3.0 0.4 10.8 0.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5366) PKD PF00801.20 KII65762.1 - 0.14 12.0 0.1 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 PKD domain Sortilin_C PF15901.5 KII65763.1 - 6.2e-11 42.9 0.4 1.3e-10 41.9 0.4 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII65763.1 - 9.9e-08 31.2 0.9 9.9e-08 31.2 0.9 2.2 3 1 0 3 3 3 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII65763.1 - 4.7e-06 25.8 3.9 0.11 12.6 0.2 3.8 3 0 0 3 3 3 3 BNR/Asp-box repeat DUF3908 PF13048.6 KII65763.1 - 0.075 13.3 6.9 2 8.7 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3908) Serpin PF00079.20 KII65764.1 - 7e-14 51.9 6.5 7.6e-14 51.8 6.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CdiI_4 PF18624.1 KII65766.1 - 0.028 14.9 0.3 0.55 10.7 0.1 2.2 2 0 0 2 2 2 0 CDI immunity protein NGP1NT PF08153.12 KII65767.1 - 6.5e-30 104.0 0.1 1.2e-29 103.1 0.1 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 KII65767.1 - 3.8e-17 62.4 0.2 2.3e-14 53.4 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 KII65767.1 - 5.1e-08 32.6 0.1 2.3e-06 27.2 0.1 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KII65767.1 - 2.2e-06 27.7 0.0 4.7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 KII65767.1 - 2.3e-05 24.5 0.6 0.012 15.7 0.1 3.4 2 1 1 3 3 3 1 Dynamin family GTP_EFTU PF00009.27 KII65767.1 - 0.064 12.8 0.1 0.83 9.2 0.0 2.4 2 1 0 3 3 3 0 Elongation factor Tu GTP binding domain tRNA-synt_1b PF00579.25 KII65768.1 - 5.1e-16 58.9 0.0 6.4e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1b PF00579.25 KII65769.1 - 0.014 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Ribosomal_S15 PF00312.22 KII65772.1 - 7.7e-15 54.9 1.0 1.2e-14 54.2 1.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 Ribosomal_S13_N PF08069.12 KII65772.1 - 2.8e-10 40.1 0.1 7.3e-10 38.7 0.0 1.7 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Kelch_4 PF13418.6 KII65773.1 - 1.4e-33 114.7 14.8 7.5e-07 29.1 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 KII65773.1 - 1.9e-32 110.5 15.4 2.5e-08 33.9 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 KII65773.1 - 2e-29 100.9 16.3 1.2e-09 37.6 0.0 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII65773.1 - 4.1e-22 78.0 10.6 1.9e-06 28.0 0.0 6.7 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KII65773.1 - 1.1e-17 63.6 19.5 1.1e-06 28.5 0.2 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KII65773.1 - 1.5e-15 56.4 13.5 8.1e-05 22.4 0.1 6.1 6 0 0 6 6 6 4 Kelch motif Anth_Ig PF05587.13 KII65773.1 - 0.027 14.8 0.0 0.051 13.9 0.0 1.4 1 0 0 1 1 1 0 Anthrax receptor extracellular domain TFIIA_gamma_C PF02751.14 KII65773.1 - 0.2 11.8 5.0 0.34 11.1 0.1 3.4 4 0 0 4 4 4 0 Transcription initiation factor IIA, gamma subunit RT_RNaseH PF17917.1 KII65775.1 - 0.038 14.3 0.2 2.2 8.6 0.0 2.3 1 1 1 2 2 2 0 RNase H-like domain found in reverse transcriptase NCU-G1 PF15065.6 KII65775.1 - 0.11 11.5 0.0 0.12 11.4 0.0 1.0 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 Ocnus PF05005.15 KII65777.1 - 0.13 12.4 0.1 0.18 11.9 0.1 1.1 1 0 0 1 1 1 0 Janus/Ocnus family (Ocnus) Profilin PF00235.19 KII65778.1 - 2.2e-05 24.7 0.6 2.6e-05 24.5 0.6 1.1 1 0 0 1 1 1 1 Profilin Lip_prot_lig_C PF10437.9 KII65778.1 - 0.019 14.9 0.3 0.027 14.5 0.3 1.2 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus DUF2149 PF09919.9 KII65779.1 - 0.066 13.5 0.7 0.14 12.5 0.7 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) Ribosomal_L1 PF00687.21 KII65780.1 - 2.5e-11 43.7 0.0 2.8e-11 43.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family TraG_N PF07916.11 KII65781.1 - 3e-108 362.7 20.8 3e-108 362.7 20.8 3.5 3 0 0 3 3 3 1 TraG-like protein, N-terminal region TraH PF06122.11 KII65781.1 - 7.7e-91 305.1 6.1 7.7e-91 305.1 6.1 3.7 4 0 0 4 4 4 2 Conjugative relaxosome accessory transposon protein Sel1 PF08238.12 KII65782.1 - 7.2e-26 90.1 11.9 1.8e-08 34.8 0.2 5.8 5 2 0 5 5 5 4 Sel1 repeat DUF1955 PF09205.10 KII65782.1 - 0.072 12.8 0.3 2.1 8.1 0.1 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF1955) DUF2149 PF09919.9 KII65784.1 - 0.056 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) MINDY_DUB PF04424.13 KII65785.1 - 5e-24 84.6 0.3 1.2e-23 83.3 0.4 1.6 2 0 0 2 2 2 1 MINDY deubiquitinase MINDY_DUB PF04424.13 KII65787.1 - 8.5e-25 87.0 0.6 1.8e-24 86.0 0.5 1.6 2 0 0 2 2 2 1 MINDY deubiquitinase SNAP PF14938.6 KII65788.1 - 1.6e-09 37.6 3.8 2.4e-09 37.0 3.8 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 KII65788.1 - 0.0044 16.7 0.8 0.0044 16.7 0.8 2.7 4 0 0 4 4 4 1 TPR repeat TPR_8 PF13181.6 KII65788.1 - 0.031 14.5 3.7 0.031 14.5 3.7 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat YscO PF07321.12 KII65788.1 - 0.05 13.6 0.1 0.1 12.6 0.1 1.6 1 0 0 1 1 1 0 Type III secretion protein YscO TPR_12 PF13424.6 KII65788.1 - 0.083 13.2 0.5 0.24 11.7 0.5 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat NSF PF02071.20 KII65788.1 - 0.083 13.6 4.9 3.1 9.0 1.2 3.7 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_1 PF00515.28 KII65788.1 - 0.9 9.5 11.5 0.1 12.5 2.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII65788.1 - 4.5 7.6 10.7 0.62 10.3 3.4 3.4 4 1 0 4 4 4 0 Tetratricopeptide repeat FHA PF00498.26 KII65789.1 - 0.095 13.1 0.2 0.21 11.9 0.2 1.7 1 0 0 1 1 1 0 FHA domain MULE PF10551.9 KII65790.1 - 0.0045 17.4 0.0 0.009 16.4 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain rve PF00665.26 KII65791.1 - 2.1e-12 47.3 0.0 2.6e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65791.1 - 0.017 14.9 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain Scaffolding_pro PF11418.8 KII65792.1 - 0.065 13.8 0.2 0.14 12.8 0.1 1.6 1 1 1 2 2 2 0 Phi29 scaffolding protein XRN1_D2_D3 PF18334.1 KII65795.1 - 0.077 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Exoribonuclease Xrn1 D2/D3 domain DUF442 PF04273.13 KII65798.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative phosphatase (DUF442) Albumin_I PF08027.11 KII65800.1 - 0.3 10.7 0.6 0.47 10.1 0.1 1.6 2 0 0 2 2 2 0 Albumin I chain b DUF5638 PF18688.1 KII65801.1 - 0.001 19.3 0.1 0.017 15.4 0.1 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5638) ACR_tran PF00873.19 KII65801.1 - 0.089 10.4 0.0 0.099 10.3 0.0 1.0 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Abhydro_lipase PF04083.16 KII65801.1 - 0.14 11.7 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region CHCH PF06747.13 KII65802.1 - 0.11 12.7 0.7 0.24 11.6 0.7 1.6 1 0 0 1 1 1 0 CHCH domain BAR_3 PF16746.5 KII65803.1 - 0.016 14.9 0.5 0.026 14.2 0.5 1.4 1 1 0 1 1 1 0 BAR domain of APPL family MMS22L_C PF14911.6 KII65804.1 - 0.069 12.2 0.1 0.074 12.1 0.1 1.2 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, C-terminal IML1 PF12257.8 KII65805.1 - 0.0041 16.3 0.2 2.2 7.3 0.0 2.1 2 0 0 2 2 2 2 Vacuolar membrane-associated protein Iml1 HSBP1 PF06825.12 KII65805.1 - 0.016 15.0 2.7 3.5 7.6 0.2 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 gag_pre-integrs PF13976.6 KII65805.1 - 0.05 13.5 0.4 13 5.7 0.1 2.7 2 1 0 2 2 2 0 GAG-pre-integrase domain Tape_meas_lam_C PF09718.10 KII65805.1 - 0.12 12.6 1.1 13 6.0 0.3 2.6 2 1 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Flp1_like PF16982.5 KII65805.1 - 0.28 10.6 0.9 20 4.7 0.1 2.3 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain PH PF00169.29 KII65806.1 - 0.07 13.7 0.5 0.12 12.9 0.5 1.5 1 1 0 1 1 1 0 PH domain RT_RNaseH PF17917.1 KII65807.1 - 7.4e-37 125.8 0.1 2.4e-36 124.2 0.1 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65807.1 - 5.7e-35 119.4 0.2 2.5e-34 117.3 0.0 2.3 3 0 0 3 3 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65807.1 - 7.9e-27 94.2 0.1 2e-26 92.9 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII65807.1 - 5.9e-25 87.8 0.0 2.3e-24 85.9 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65807.1 - 2.3e-17 62.8 0.2 1e-16 60.8 0.2 2.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 KII65807.1 - 6.3e-06 26.0 11.2 0.0024 17.9 2.0 2.7 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII65807.1 - 3.8e-05 23.9 0.0 0.00019 21.7 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII65807.1 - 0.00035 21.2 0.0 0.00086 19.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII65807.1 - 0.00044 20.7 0.0 0.001 19.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII65807.1 - 0.0014 18.4 0.1 0.0037 17.1 0.1 1.7 1 1 0 1 1 1 1 Aspartyl protease rve_3 PF13683.6 KII65807.1 - 0.0033 17.1 0.0 0.011 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.11 KII65807.1 - 0.0056 16.5 0.3 0.012 15.4 0.3 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.6 KII65807.1 - 0.0097 15.9 5.9 0.025 14.6 0.5 2.5 1 1 1 2 2 2 1 Zinc knuckle zf-H2C2 PF09337.10 KII65807.1 - 0.086 13.1 0.8 0.36 11.1 0.1 2.5 2 0 0 2 2 2 0 H2C2 zinc finger Herpes_UL14 PF03580.14 KII65807.1 - 0.092 13.0 0.8 0.17 12.1 0.0 1.8 2 0 0 2 2 1 0 Herpesvirus UL14-like protein Peptidase_A2B PF12384.8 KII65807.1 - 0.12 11.9 0.0 0.61 9.6 0.0 2.0 1 1 0 2 2 2 0 Ty3 transposon peptidase Zn_Tnp_IS91 PF14319.6 KII65807.1 - 0.56 10.3 7.9 0.38 10.8 3.7 2.9 2 0 0 2 2 2 0 Transposase zinc-binding domain PHD_4 PF16866.5 KII65807.1 - 8.1 6.6 7.3 1.3 9.2 1.3 2.8 3 1 1 4 4 4 0 PHD-finger DDE_3 PF13358.6 KII65808.1 - 0.0016 18.2 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease SSXT PF05030.12 KII65808.1 - 0.18 11.4 0.9 0.47 10.1 0.9 1.8 1 1 0 1 1 1 0 SSXT protein (N-terminal region) Peptidase_M17_N PF02789.17 KII65810.1 - 0.025 14.4 0.0 0.63 9.9 0.0 2.0 1 1 1 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.21 KII65811.1 - 3.1e-99 332.2 0.0 3.5e-99 332.0 0.0 1.0 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain WD40 PF00400.32 KII65815.1 - 3.5e-33 113.1 23.3 1.1e-06 29.3 0.6 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII65815.1 - 4.5e-09 36.5 3.1 0.08 13.2 0.2 4.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KII65815.1 - 3.8e-08 32.4 10.8 0.067 11.8 0.1 5.9 2 1 3 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 KII65815.1 - 2.4e-05 23.8 0.1 0.046 13.0 0.0 2.9 1 1 1 2 2 2 2 WD40-like domain Nucleoporin_N PF08801.11 KII65815.1 - 0.0053 15.6 3.5 0.038 12.7 0.2 3.5 2 1 1 3 3 3 1 Nup133 N terminal like MULE PF10551.9 KII65818.1 - 0.04 14.3 0.0 0.06 13.8 0.0 1.3 1 0 0 1 1 1 0 MULE transposase domain zf-C2H2 PF00096.26 KII65820.1 - 1.8e-17 62.7 47.8 5.9e-05 23.3 4.2 7.3 6 1 1 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KII65820.1 - 2.8e-12 46.5 21.4 2.8e-06 27.5 2.2 7.4 9 1 0 9 9 8 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KII65820.1 - 1.5e-10 41.1 23.6 0.055 13.8 1.5 5.9 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KII65820.1 - 2.1e-10 40.5 44.8 0.0015 19.2 3.3 7.0 6 1 1 7 7 7 5 C2H2-type zinc finger zf-met PF12874.7 KII65820.1 - 0.0017 18.7 30.2 0.65 10.5 0.1 6.4 6 0 0 6 6 6 4 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 KII65820.1 - 0.003 17.6 19.8 0.069 13.3 1.0 4.9 4 0 0 4 4 4 2 Zinc ribbon domain zf-C2H2_6 PF13912.6 KII65820.1 - 0.0047 16.9 28.8 0.014 15.4 1.6 4.9 5 0 0 5 5 5 2 C2H2-type zinc finger zinc_ribbon_9 PF14369.6 KII65820.1 - 0.17 12.2 14.0 0.31 11.4 0.2 5.3 5 0 0 5 5 5 0 zinc-ribbon Spt46 PF17734.1 KII65820.1 - 0.68 9.7 8.2 1.6 8.4 0.4 2.9 1 1 1 2 2 2 0 Spermatogenesis-associated protein 46 Glutaredoxin PF00462.24 KII65820.1 - 0.71 10.1 2.8 2.6 8.3 0.2 2.8 2 0 0 2 2 2 0 Glutaredoxin zf-C2H2_9 PF16293.5 KII65820.1 - 0.73 9.7 8.0 0.31 10.9 0.9 3.5 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) C1_4 PF07975.12 KII65820.1 - 7.1 6.9 0.0 7.1 6.9 0.0 4.8 3 1 3 6 6 6 0 TFIIH C1-like domain HTH_Tnp_Tc5 PF03221.16 KII65821.1 - 0.00016 21.6 0.0 0.00032 20.7 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CDC50 PF03381.15 KII65822.1 - 4.8e-23 82.1 0.2 5.4e-23 81.9 0.2 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DDE_1 PF03184.19 KII65823.1 - 7e-05 22.6 0.0 0.0001 22.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RIG-I_C PF18119.1 KII65824.1 - 0.054 13.5 0.0 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 RIG-I receptor C-terminal domain zf-C2H2 PF00096.26 KII65828.1 - 0.0097 16.3 10.0 0.54 10.8 1.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 KII65828.1 - 0.019 15.1 0.3 0.019 15.1 0.3 1.8 2 0 0 2 2 2 0 Aberrant zinc-finger FLYWCH PF04500.16 KII65830.1 - 0.00096 19.2 2.7 0.0015 18.6 2.7 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain Hormone_4 PF00220.17 KII65830.1 - 0.59 10.2 5.3 0.94 9.6 0.5 2.6 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain DDE_Tnp_IS1595 PF12762.7 KII65832.1 - 0.05 13.6 0.0 0.074 13.0 0.0 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain NRDD PF13597.6 KII65833.1 - 0.11 11.2 0.1 0.13 11.0 0.1 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase Sortilin-Vps10 PF15902.5 KII65834.1 - 0.00054 18.9 0.0 0.0031 16.4 0.0 2.0 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII65834.1 - 0.034 14.1 0.8 26 5.3 0.0 3.7 3 0 0 3 3 3 0 BNR/Asp-box repeat PLAC8 PF04749.17 KII65835.1 - 3e-14 53.8 9.4 3.5e-14 53.6 9.4 1.1 1 0 0 1 1 1 1 PLAC8 family MurJ PF03023.14 KII65835.1 - 0.17 10.5 0.0 0.19 10.3 0.0 1.0 1 0 0 1 1 1 0 Lipid II flippase MurJ PLAC8 PF04749.17 KII65837.1 - 8.2e-09 36.4 8.2 1.1e-08 36.0 8.2 1.3 1 1 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KII65838.1 - 1.1e-16 61.7 10.6 1.3e-16 61.4 10.6 1.1 1 0 0 1 1 1 1 PLAC8 family RT_RNaseH_2 PF17919.1 KII65839.1 - 8.8e-19 67.4 0.0 2.6e-18 65.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65839.1 - 2.6e-15 56.6 0.0 8.9e-15 54.9 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII65839.1 - 0.0086 16.2 0.1 0.03 14.4 0.1 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain TIR_3 PF18567.1 KII65842.1 - 0.09 12.8 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Toll/interleukin-1 receptor domain RVP PF00077.20 KII65844.1 - 0.024 14.9 0.0 0.038 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease RVP_2 PF08284.11 KII65844.1 - 0.034 13.9 0.1 0.046 13.5 0.1 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease RVT_1 PF00078.27 KII65847.1 - 0.00041 19.9 0.0 0.0008 19.0 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 KII65849.1 - 1.2e-69 234.7 0.0 2e-69 233.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII65849.1 - 3.1e-49 167.6 0.0 4.7e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KII65849.1 - 2.1e-08 33.3 0.0 4.5e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Mst1_SARAH PF11629.8 KII65849.1 - 4.6e-06 26.6 0.7 1.4e-05 25.0 0.2 2.2 2 0 0 2 2 2 1 C terminal SARAH domain of Mst1 RVP PF00077.20 KII65850.1 - 0.004 17.4 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII65850.1 - 0.0081 16.7 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII65850.1 - 0.018 15.1 4.3 0.035 14.2 4.3 1.5 1 0 0 1 1 1 0 Zinc knuckle RT_RNaseH PF17917.1 KII65851.1 - 9.8e-34 115.8 0.1 2.4e-33 114.6 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65851.1 - 5.2e-33 113.1 0.0 1.2e-32 111.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65851.1 - 3.6e-31 108.4 0.3 7e-31 107.5 0.3 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII65851.1 - 6.7e-20 71.5 0.0 1.9e-19 70.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65851.1 - 1.3e-15 57.2 1.8 3.5e-15 55.8 1.8 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain RVP PF00077.20 KII65851.1 - 0.016 15.5 0.0 0.037 14.3 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII65851.1 - 0.027 15.0 0.0 0.056 14.0 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 KII65851.1 - 0.11 12.2 0.0 0.37 10.6 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH PF17917.1 KII65852.1 - 6.1e-34 116.5 0.0 9.7e-34 115.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII65852.1 - 7.5e-30 102.9 0.0 1.8e-29 101.7 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65852.1 - 3.5e-10 39.8 0.0 5.6e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII65853.1 - 1.4e-11 44.7 0.0 2e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII65853.1 - 1.5e-05 24.6 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DUF572 PF04502.13 KII65854.1 - 6.9e-42 144.2 5.3 7.6e-42 144.1 5.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) HypA PF01155.19 KII65854.1 - 0.0046 17.0 0.0 0.0062 16.5 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Mu-like_Com PF10122.9 KII65854.1 - 0.01 15.2 0.1 0.87 9.1 0.1 2.3 2 0 0 2 2 2 0 Mu-like prophage protein Com zf-ACC PF17848.1 KII65854.1 - 0.012 15.7 3.0 1.2 9.3 0.6 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain E7 PF00527.18 KII65854.1 - 0.18 12.0 0.6 0.73 10.1 0.2 1.8 1 1 1 2 2 2 0 E7 protein, Early protein zf_UBZ PF18439.1 KII65854.1 - 0.7 9.5 2.4 18 5.1 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF572 PF04502.13 KII65855.1 - 7.1e-06 25.9 3.6 8e-06 25.7 3.6 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Trm112p PF03966.16 KII65858.1 - 1.6e-11 44.6 0.0 1.8e-11 44.4 0.0 1.0 1 0 0 1 1 1 1 Trm112p-like protein Sortilin-Vps10 PF15902.5 KII65860.1 - 2.5e-11 43.1 1.0 3.4e-11 42.6 1.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII65860.1 - 1.5e-06 27.3 2.1 0.39 10.9 0.0 3.6 3 0 0 3 3 3 3 BNR/Asp-box repeat RVT_1 PF00078.27 KII65862.1 - 3.6e-11 43.0 0.0 6.2e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BNR PF02012.20 KII65863.1 - 0.0061 16.4 0.0 0.32 11.2 0.0 2.5 2 0 0 2 2 2 1 BNR/Asp-box repeat NigD_N PF12667.7 KII65863.1 - 0.029 14.5 0.0 0.06 13.4 0.0 1.5 1 0 0 1 1 1 0 NigD-like N-terminal OB domain AT_hook PF02178.19 KII65864.1 - 0.094 12.6 4.0 0.097 12.6 1.4 2.2 2 0 0 2 2 2 0 AT hook motif NUP214 PF16755.5 KII65865.1 - 0.0091 15.3 2.0 0.0091 15.3 2.0 2.2 2 1 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 RNA_pol_L_2 PF13656.6 KII65869.1 - 2.6e-19 68.8 0.0 3.8e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KII65869.1 - 0.00037 19.9 0.0 0.0016 17.8 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DDE_Tnp_IS1595 PF12762.7 KII65870.1 - 1.6e-05 25.0 0.0 2.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF3648 PF12364.8 KII65872.1 - 0.19 12.0 2.1 3.2 8.0 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3648) Pkinase PF00069.25 KII65873.1 - 4.9e-19 68.7 0.1 5.5e-19 68.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII65873.1 - 6.1e-09 35.5 0.1 7.5e-09 35.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Casc1_N PF15927.5 KII65874.1 - 0.031 14.0 1.2 0.048 13.4 1.2 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Ca_hom_mod PF14798.6 KII65875.1 - 7.2e-09 35.1 0.6 9.3e-06 24.9 0.1 2.1 1 1 1 2 2 2 2 Calcium homeostasis modulator DUF1761 PF08570.10 KII65875.1 - 0.045 14.0 0.1 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1761) Neurensin PF14927.6 KII65875.1 - 0.13 12.0 0.6 0.33 10.7 0.6 1.8 1 1 0 1 1 1 0 Neurensin Ca_hom_mod PF14798.6 KII65876.1 - 0.00026 20.2 3.0 0.012 14.8 0.5 2.1 1 1 1 2 2 2 2 Calcium homeostasis modulator AceK PF06315.11 KII65876.1 - 0.043 12.3 0.1 0.059 11.9 0.1 1.2 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) Ni_hydr_CYTB PF01292.20 KII65876.1 - 0.046 13.3 1.3 0.064 12.9 1.3 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 GPI2 PF06432.11 KII65876.1 - 0.28 10.6 1.9 0.53 9.7 1.5 1.7 1 1 1 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase DUF975 PF06161.11 KII65876.1 - 0.64 9.8 12.1 0.75 9.5 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF975) Ac76 PF05814.11 KII65876.1 - 4.1 7.5 9.9 2 8.5 1.0 2.7 3 0 0 3 3 3 0 Orf76 (Ac76) XPG_I PF00867.18 KII65877.1 - 5.5e-26 90.7 0.5 1.4e-25 89.5 0.1 2.0 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 KII65877.1 - 6.1e-21 74.8 0.1 2e-20 73.1 0.1 2.0 1 0 0 1 1 1 1 XPG N-terminal domain Pox_G5 PF04599.12 KII65877.1 - 0.0076 15.3 0.9 0.018 14.0 0.0 2.0 2 0 0 2 2 2 1 Poxvirus G5 protein 5_3_exonuc PF01367.20 KII65877.1 - 0.2 12.3 0.7 1.8 9.2 0.0 2.8 3 0 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold MFA1_2 PF17317.2 KII65879.1 - 6.3e-10 38.7 15.5 17 5.2 0.0 8.3 8 0 0 8 8 8 8 Mating hormone A-factor 1&2 VirDNA-topo-I_N PF09266.10 KII65879.1 - 0.0049 17.0 33.9 31 4.8 0.2 9.1 1 1 8 9 9 9 8 Viral DNA topoisomerase I, N-terminal CagY_M PF07337.11 KII65880.1 - 0.033 13.8 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 DC-EC Repeat E3_UFM1_ligase PF09743.9 KII65883.1 - 4.1e-40 138.1 1.9 5.3e-40 137.7 1.9 1.1 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 Lipoxygenase PF00305.19 KII65885.1 - 6.9e-22 77.7 0.1 9.2e-22 77.2 0.1 1.1 1 0 0 1 1 1 1 Lipoxygenase PLAT PF01477.23 KII65886.1 - 6.8e-08 33.1 0.2 1.4e-07 32.1 0.2 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Lipoxygenase PF00305.19 KII65886.1 - 0.00097 17.7 0.0 0.0016 17.0 0.0 1.3 1 0 0 1 1 1 1 Lipoxygenase SAM_decarbox PF01536.16 KII65887.1 - 2.9e-63 214.0 0.1 3.8e-63 213.6 0.1 1.2 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Glyco_hydro_65N PF03636.15 KII65888.1 - 0.00021 21.0 4.9 0.55 9.8 1.4 3.5 1 1 1 2 2 2 2 Glycosyl hydrolase family 65, N-terminal domain Tafi-CsgC PF10610.9 KII65888.1 - 0.0047 17.1 1.2 32 4.8 0.1 3.4 3 0 0 3 3 3 3 Thin aggregative fimbriae synthesis protein SepA PF17080.5 KII65888.1 - 0.026 14.9 10.6 5 7.5 0.4 3.4 1 1 2 3 3 3 0 Multidrug Resistance efflux pump Transglut_C PF00927.22 KII65889.1 - 0.0019 18.3 0.8 0.44 10.7 0.1 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain DUF5011 PF16403.5 KII65889.1 - 0.1 12.7 1.2 0.25 11.5 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) Transglut_N PF00868.20 KII65890.1 - 7.4e-05 23.1 0.0 0.0001 22.6 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase family SAM_decarbox PF01536.16 KII65891.1 - 6.1e-65 219.5 0.0 7.4e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Topo_Zn_Ribbon PF08272.11 KII65891.1 - 0.033 13.8 0.0 9.1 6.0 0.0 2.8 2 0 0 2 2 2 0 Topoisomerase I zinc-ribbon-like Usp PF00582.26 KII65892.1 - 2.5e-05 24.8 0.0 0.098 13.2 0.0 2.1 2 0 0 2 2 2 2 Universal stress protein family WD40 PF00400.32 KII65893.1 - 3.8e-24 84.5 16.6 1.5e-06 28.8 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII65893.1 - 5.5e-09 36.2 0.2 0.81 10.0 0.0 5.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KII65893.1 - 0.00012 21.5 0.8 0.042 13.2 0.1 3.6 2 1 2 4 4 4 1 WD40-like domain Frtz PF11768.8 KII65893.1 - 0.0029 16.0 0.2 0.95 7.7 0.1 2.1 1 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KII65893.1 - 0.013 15.4 0.1 0.37 10.7 0.0 2.6 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A NPR1_interact PF15699.5 KII65895.1 - 0.024 15.3 2.8 3.6 8.3 0.1 2.1 2 0 0 2 2 2 0 NPR1 interacting KNOX2 PF03791.13 KII65895.1 - 0.054 13.0 0.5 0.054 13.0 0.5 2.2 2 0 0 2 2 2 0 KNOX2 domain HSCB_C PF07743.13 KII65895.1 - 0.63 10.6 4.3 0.62 10.6 0.2 2.6 2 2 2 4 4 4 0 HSCB C-terminal oligomerisation domain CarboxypepD_reg PF13620.6 KII65896.1 - 3e-15 56.2 0.0 4.8e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CAP_GLY PF01302.25 KII65896.1 - 2.3e-09 37.1 0.0 3.6e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain CarbopepD_reg_2 PF13715.6 KII65896.1 - 2.3e-08 33.9 0.0 4.3e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain PEGA PF08308.11 KII65896.1 - 0.01 15.7 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 0 PEGA domain Peptidase_M14 PF00246.24 KII65897.1 - 1.4e-27 97.3 0.2 1.9e-27 96.8 0.2 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF2817 PF10994.8 KII65897.1 - 0.061 12.7 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Peptidase_M14 PF00246.24 KII65898.1 - 1.8e-27 96.9 0.0 2.9e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF3439 PF11921.8 KII65898.1 - 0.071 13.1 0.6 0.11 12.5 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Rpr2 PF04032.16 KII65899.1 - 0.02 15.2 0.6 0.065 13.5 0.1 2.1 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2H2 PF00096.26 KII65900.1 - 1.1e-15 57.1 18.8 2.4e-05 24.5 3.2 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KII65900.1 - 1.5e-11 44.1 15.8 9.9e-06 25.8 0.4 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KII65900.1 - 2.2e-10 40.4 15.9 0.0052 17.5 1.9 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 KII65900.1 - 2.3e-09 37.3 9.7 0.017 15.5 0.3 3.7 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KII65900.1 - 2.1e-06 27.9 5.4 0.033 14.5 0.1 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 KII65900.1 - 0.0032 17.5 16.3 0.015 15.4 3.5 3.6 2 1 1 3 3 3 2 BED zinc finger zf-Di19 PF05605.12 KII65900.1 - 0.0074 16.6 1.2 0.0074 16.6 1.2 2.3 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 KII65900.1 - 0.043 13.8 14.0 0.071 13.1 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Spt46 PF17734.1 KII65900.1 - 0.044 13.6 0.4 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Spermatogenesis-associated protein 46 zf-C2H2_11 PF16622.5 KII65900.1 - 0.044 13.5 0.7 0.044 13.5 0.7 3.4 3 1 0 3 3 3 0 zinc-finger C2H2-type DUF4879 PF16219.5 KII65900.1 - 0.14 12.4 1.3 0.66 10.2 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4879) zf-C2H2_2 PF12756.7 KII65900.1 - 0.55 10.6 8.9 14 6.1 0.1 3.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DDE_Tnp_IS1595 PF12762.7 KII65901.1 - 0.0084 16.1 0.0 0.019 15.0 0.0 1.7 2 0 0 2 2 2 1 ISXO2-like transposase domain Pkinase PF00069.25 KII65902.1 - 5e-48 163.8 0.1 3.5e-47 161.0 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII65902.1 - 3.6e-27 95.3 0.0 4.4e-25 88.5 0.0 2.8 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 KII65903.1 - 1.2e-14 54.3 0.0 1.5e-14 54.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII65903.1 - 4.4e-07 29.4 0.0 5.1e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KII65903.1 - 0.14 10.9 0.0 0.16 10.7 0.0 1.0 1 0 0 1 1 1 0 Fungal protein kinase DUF953 PF06110.11 KII65905.1 - 3.4e-18 65.4 0.0 3.9e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_7 PF13899.6 KII65905.1 - 0.0076 16.4 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like TF_Zn_Ribbon PF08271.12 KII65905.1 - 0.085 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding AMP-binding PF00501.28 KII65908.1 - 2.7e-24 85.5 0.0 3.6e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Post_transc_reg PF13797.6 KII65908.1 - 0.045 13.6 0.0 0.59 10.0 0.0 2.3 2 0 0 2 2 2 0 Post-transcriptional regulator AMP-binding PF00501.28 KII65909.1 - 1.7e-42 145.5 0.0 2.3e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme CRA PF06589.11 KII65914.1 - 0.45 10.6 5.5 0.77 9.9 5.5 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Met_10 PF02475.16 KII65917.1 - 2.5e-45 154.7 0.2 3.9e-45 154.1 0.2 1.2 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 KII65917.1 - 9.3e-06 25.1 0.1 2.8e-05 23.5 0.1 1.7 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_25 PF13649.6 KII65917.1 - 0.00045 20.9 0.0 0.0014 19.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KII65917.1 - 0.0021 17.6 0.0 0.0034 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 KII65917.1 - 0.0027 17.2 0.0 0.0044 16.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 KII65917.1 - 0.0064 16.1 0.1 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.7 KII65917.1 - 0.039 13.9 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FmrO PF07091.11 KII65917.1 - 0.065 12.8 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) AAA PF00004.29 KII65918.1 - 4.9e-36 124.1 0.0 1.1e-35 122.9 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KII65918.1 - 9.7e-12 44.7 0.7 2.4e-11 43.4 0.7 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 KII65918.1 - 1.6e-11 43.8 0.0 3.8e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KII65918.1 - 1.3e-06 28.9 0.1 0.0017 18.8 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 KII65918.1 - 2.6e-06 27.7 0.0 5.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 KII65918.1 - 3.7e-05 23.0 0.0 8.6e-05 21.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 KII65918.1 - 8.7e-05 22.5 0.1 0.00035 20.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_OB_N PF17758.1 KII65918.1 - 0.00021 20.9 0.4 0.0023 17.5 0.2 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain RuvB_N PF05496.12 KII65918.1 - 0.00059 19.6 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KII65918.1 - 0.00082 19.9 0.0 0.0033 18.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KII65918.1 - 0.00085 18.8 0.1 0.0016 17.8 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KII65918.1 - 0.0012 19.1 0.3 0.042 14.1 0.0 2.5 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 KII65918.1 - 0.0016 17.7 0.0 0.0033 16.7 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 KII65918.1 - 0.0023 17.7 0.1 0.01 15.5 0.0 2.0 1 1 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KII65918.1 - 0.0031 17.9 0.0 0.0079 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase DUF3666 PF12408.8 KII65918.1 - 0.0034 16.6 0.2 0.046 12.9 0.0 2.9 3 0 0 3 3 2 1 Ribose-5-phosphate isomerase AAA_28 PF13521.6 KII65918.1 - 0.0036 17.6 0.0 0.0069 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KII65918.1 - 0.0042 16.8 0.3 0.014 15.1 0.3 1.9 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 KII65918.1 - 0.0047 16.8 0.1 0.031 14.2 0.0 2.3 3 0 0 3 3 3 1 NTPase AAA_33 PF13671.6 KII65918.1 - 0.0073 16.5 0.1 0.016 15.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KII65918.1 - 0.0099 15.4 0.1 0.069 12.7 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region TsaE PF02367.17 KII65918.1 - 0.017 15.1 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 KII65918.1 - 0.036 13.2 0.0 0.073 12.1 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 KII65918.1 - 0.036 13.8 0.1 0.12 12.1 0.0 2.0 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 KII65918.1 - 0.044 13.5 0.1 0.11 12.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KII65918.1 - 0.046 13.3 0.5 0.12 12.0 0.4 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KII65918.1 - 0.056 13.4 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain PhoH PF02562.16 KII65918.1 - 0.077 12.4 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 KII65918.1 - 0.081 12.0 0.0 0.19 10.8 0.0 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 KII65918.1 - 0.085 12.9 0.0 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 KII65918.1 - 0.11 12.4 0.0 0.42 10.5 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 KII65918.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 2 0 0 2 2 1 0 AAA domain TniB PF05621.11 KII65918.1 - 0.13 11.6 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Ras PF00071.22 KII65919.1 - 3.2e-34 117.9 0.1 3.7e-34 117.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII65919.1 - 1.1e-11 45.0 0.0 1.8e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KII65919.1 - 1.5e-07 31.5 0.0 2.7e-07 30.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 KII65919.1 - 1.4e-06 27.9 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AIG1 PF04548.16 KII65919.1 - 2.2e-05 23.9 0.0 4.8e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 AIG1 family AAA_31 PF13614.6 KII65919.1 - 0.0001 22.3 3.6 0.046 13.6 0.1 2.4 1 1 1 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 KII65919.1 - 0.00011 22.1 0.7 0.4 10.6 0.1 2.4 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KII65919.1 - 0.00072 19.2 0.7 0.0034 16.9 0.7 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 KII65919.1 - 0.0021 17.3 0.1 0.0094 15.2 0.0 1.9 2 0 0 2 2 2 1 NB-ARC domain DUF2325 PF10087.9 KII65919.1 - 0.021 14.9 0.1 0.06 13.5 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) IstB_IS21 PF01695.17 KII65919.1 - 0.023 14.5 0.3 0.047 13.4 0.2 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein Mrx7 PF10906.8 KII65919.1 - 0.034 14.4 0.1 0.11 12.8 0.1 1.8 1 0 0 1 1 1 0 MIOREX complex component 7 ArsA_ATPase PF02374.15 KII65919.1 - 0.063 12.5 0.8 0.063 12.5 0.8 2.5 2 2 1 3 3 3 0 Anion-transporting ATPase FeoB_N PF02421.18 KII65919.1 - 0.065 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 KII65919.1 - 0.067 12.9 0.8 0.19 11.4 0.8 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 KII65919.1 - 0.068 12.9 3.4 0.88 9.3 3.4 2.3 1 1 0 1 1 1 0 AAA domain CbiA PF01656.23 KII65919.1 - 0.4 10.7 2.4 0.99 9.5 2.4 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain WW PF00397.26 KII65922.1 - 1.7e-08 34.4 0.8 3.2e-08 33.5 0.8 1.5 1 0 0 1 1 1 1 WW domain GDA1_CD39 PF01150.17 KII65923.1 - 5.3e-61 206.6 0.0 6.6e-61 206.2 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Herpes_UL36 PF03586.13 KII65926.1 - 0.042 13.1 0.4 0.18 11.1 0.1 1.9 2 0 0 2 2 2 0 Herpesvirus UL36 tegument protein YlbD_coat PF14071.6 KII65926.1 - 0.064 13.5 1.3 1.9 8.7 0.6 2.3 1 1 1 2 2 2 0 Putative coat protein rve PF00665.26 KII65927.1 - 3.7e-17 62.6 0.0 4.1e-16 59.2 0.0 2.6 3 0 0 3 3 3 1 Integrase core domain RVP_2 PF08284.11 KII65927.1 - 7.2e-09 35.5 0.4 1.5e-08 34.5 0.4 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease MLVIN_C PF18697.1 KII65927.1 - 4.6e-06 26.6 0.0 1.2e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Integrase_H2C2 PF17921.1 KII65927.1 - 1.8e-05 24.8 0.0 5.6e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII65927.1 - 9.1e-05 23.0 0.0 0.00024 21.6 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 KII65927.1 - 0.046 13.5 0.2 0.21 11.4 0.0 2.3 2 0 0 2 2 2 0 Integrase core domain Asp_protease PF09668.10 KII65927.1 - 0.21 11.4 0.8 0.4 10.5 0.2 1.8 2 0 0 2 2 2 0 Aspartyl protease TM231 PF10149.9 KII65927.1 - 4.9 6.4 7.6 0.92 8.8 0.1 2.5 3 0 0 3 3 3 0 Transmembrane protein 231 LMBR1 PF04791.16 KII65928.1 - 0.0011 18.0 1.5 0.0014 17.6 1.5 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein Chordopox_A13L PF05961.11 KII65930.1 - 0.06 13.6 0.1 0.26 11.5 0.1 2.1 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Ctf8 PF09696.10 KII65930.1 - 0.6 10.4 3.2 0.77 10.1 2.0 1.8 1 1 0 1 1 1 0 Ctf8 Peptidase_U57 PF05582.12 KII65930.1 - 2.7 7.2 6.2 5.9 6.1 4.1 2.2 1 1 1 2 2 2 0 YabG peptidase U57 DUF945 PF06097.11 KII65932.1 - 0.043 12.9 0.2 0.079 12.1 0.2 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) SNAP PF14938.6 KII65933.1 - 3.7e-10 39.7 3.7 4.8e-10 39.3 3.7 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RE_NgoBV PF09564.10 KII65933.1 - 0.00031 20.3 0.3 0.00076 19.0 0.1 1.6 1 1 0 1 1 1 1 NgoBV restriction endonuclease Fungal_lectin PF07938.12 KII65933.1 - 0.031 13.7 0.6 0.039 13.3 0.6 1.1 1 0 0 1 1 1 0 Fungal fucose-specific lectin Patched PF02460.18 KII65935.1 - 9.2e-12 43.9 5.5 1e-11 43.8 5.5 1.0 1 0 0 1 1 1 1 Patched family TMEM173 PF15009.6 KII65935.1 - 0.025 13.7 1.1 0.027 13.6 1.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 173 Lipase_GDSL PF00657.22 KII65938.1 - 0.079 12.9 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase DUF4849 PF16141.5 KII65938.1 - 0.086 12.1 1.3 0.11 11.7 1.3 1.1 1 0 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 RNA_GG_bind PF10258.9 KII65939.1 - 0.065 13.3 0.0 0.54 10.3 0.0 2.0 1 1 1 2 2 2 0 PHAX RNA-binding domain DUF262 PF03235.14 KII65940.1 - 0.075 13.2 0.2 0.075 13.2 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF262 Gal-3-0_sulfotr PF06990.11 KII65942.1 - 2.4e-10 39.9 1.8 3.4e-09 36.1 1.8 1.9 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Tagatose_6_P_K PF08013.11 KII65944.1 - 0.26 9.9 1.6 0.26 9.9 1.6 1.0 1 0 0 1 1 1 0 Tagatose 6 phosphate kinase E1_DerP2_DerF2 PF02221.15 KII65945.1 - 2.2e-08 34.6 0.1 2.4e-08 34.5 0.1 1.0 1 0 0 1 1 1 1 ML domain DUF4945 PF16303.5 KII65946.1 - 0.0039 17.1 0.6 0.012 15.6 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4945) PH_9 PF15410.6 KII65946.1 - 0.014 15.8 0.7 0.15 12.4 0.3 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain RSB_motif PF16294.5 KII65946.1 - 0.1 12.9 0.5 0.24 11.7 0.5 1.6 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif PurA PF04845.13 KII65952.1 - 5e-11 42.3 0.1 2.4e-07 30.3 0.0 2.5 2 1 0 2 2 2 2 PurA ssDNA and RNA-binding protein BRCA-2_helical PF09169.10 KII65953.1 - 0.061 13.0 0.0 0.082 12.6 0.0 1.2 1 0 0 1 1 1 0 BRCA2, helical NUC153 PF08159.12 KII65954.1 - 1.6e-11 43.8 0.5 1.2e-10 41.0 0.2 2.6 2 0 0 2 2 2 1 NUC153 domain RRM_1 PF00076.22 KII65954.1 - 0.022 14.5 0.1 0.061 13.1 0.1 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TBCA PF02970.16 KII65955.1 - 4.2e-10 39.8 5.5 4.9e-10 39.6 5.5 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A BAR PF03114.18 KII65955.1 - 4.9e-05 23.1 2.2 5.7e-05 22.9 2.2 1.0 1 0 0 1 1 1 1 BAR domain EzrA PF06160.12 KII65955.1 - 0.00019 19.7 3.3 0.00021 19.6 3.3 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA YkyA PF10368.9 KII65955.1 - 0.0018 18.0 2.8 0.0021 17.8 2.8 1.1 1 0 0 1 1 1 1 Putative cell-wall binding lipoprotein DUF948 PF06103.11 KII65955.1 - 0.0049 17.1 2.3 0.16 12.2 0.9 2.1 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 KII65955.1 - 0.01 15.9 2.3 0.012 15.6 2.3 1.2 1 0 0 1 1 1 0 Laminin Domain II GLYCAM-1 PF05242.11 KII65955.1 - 0.015 15.4 0.3 0.018 15.1 0.3 1.2 1 0 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) Goodbye PF17109.5 KII65955.1 - 0.039 14.4 0.1 0.046 14.2 0.1 1.2 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain Fib_alpha PF08702.10 KII65955.1 - 0.053 13.7 3.2 0.064 13.4 3.2 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family SMC_N PF02463.19 KII65959.1 - 5.8e-37 127.2 0.2 6.3e-37 127.1 0.2 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KII65959.1 - 0.00014 21.8 0.1 0.00017 21.5 0.1 1.3 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_hinge PF06470.13 KII65960.1 - 1e-22 80.7 0.0 2.9e-22 79.2 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain Ribosomal_S4 PF00163.19 KII65960.1 - 0.0013 19.6 1.4 0.0013 19.6 1.4 2.7 3 0 0 3 3 2 1 Ribosomal protein S4/S9 N-terminal domain Spc7 PF08317.11 KII65960.1 - 0.0019 17.2 19.8 0.0019 17.2 19.8 5.2 3 2 3 6 6 6 3 Spc7 kinetochore protein HBM PF16591.5 KII65960.1 - 0.0091 15.4 10.6 0.0091 15.4 10.6 4.1 3 1 1 4 4 4 1 Helical bimodular sensor domain ERM PF00769.19 KII65960.1 - 0.043 13.6 53.9 0.016 15.0 23.5 3.1 2 1 1 3 3 3 0 Ezrin/radixin/moesin family APG6_N PF17675.1 KII65960.1 - 0.05 14.1 75.1 0.49 10.9 8.5 5.6 3 1 3 6 6 6 0 Apg6 coiled-coil region Laminin_II PF06009.12 KII65960.1 - 0.4 10.7 53.5 0.19 11.7 12.6 5.6 3 1 2 6 6 6 0 Laminin Domain II APG17 PF04108.12 KII65960.1 - 0.78 8.8 44.3 0.044 12.9 9.6 4.4 3 1 1 4 4 4 0 Autophagy protein Apg17 CEP63 PF17045.5 KII65960.1 - 1.2 9.0 63.2 0.028 14.3 24.8 4.3 2 1 2 4 4 4 0 Centrosomal protein of 63 kDa HrpB7 PF09486.10 KII65960.1 - 1.3 9.4 25.3 0.043 14.2 9.0 4.3 3 1 2 5 5 5 0 Bacterial type III secretion protein (HrpB7) AFP_2 PF18815.1 KII65960.1 - 1.3 9.3 3.5 2.5 8.4 2.0 2.2 2 0 0 2 2 2 0 Bacterial antifreeze protein repeat AAA_13 PF13166.6 KII65960.1 - 1.7 7.2 59.9 1.9 7.0 33.1 3.4 2 1 1 3 3 3 0 AAA domain DUF4164 PF13747.6 KII65960.1 - 4.4 7.6 30.5 1 9.7 1.7 5.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4164) THOC7 PF05615.13 KII65960.1 - 8.8 6.6 57.4 0.2 12.0 12.7 6.5 3 2 2 5 5 4 0 Tho complex subunit 7 SMC_N PF02463.19 KII65961.1 - 1.4e-35 122.7 7.2 5.4e-35 120.8 7.2 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KII65961.1 - 3.7e-10 40.6 22.9 1.1e-08 35.8 22.9 2.0 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 KII65961.1 - 4.3e-07 30.0 21.2 6e-07 29.5 21.2 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KII65961.1 - 1.4e-05 25.1 2.2 2.3e-05 24.4 2.2 1.8 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KII65961.1 - 7.3e-05 22.4 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain TSP_NTD PF17804.1 KII65961.1 - 0.043 14.1 8.5 0.062 13.6 7.7 1.6 1 1 1 2 2 2 0 Tail specific protease N-terminal domain Lipl32 PF12103.8 KII65961.1 - 0.059 13.0 0.7 0.11 12.2 0.7 1.4 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order ABC_tran PF00005.27 KII65961.1 - 0.32 11.5 4.4 1.5 9.4 4.4 2.3 1 1 0 1 1 1 0 ABC transporter Atg14 PF10186.9 KII65961.1 - 0.38 9.8 8.3 0.61 9.1 8.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SMC_N PF02463.19 KII65962.1 - 1.4e-35 122.8 7.2 5.3e-35 120.9 7.2 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KII65962.1 - 2.4e-10 41.3 22.1 8.7e-09 36.2 22.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 KII65962.1 - 4.2e-07 30.0 20.1 6.2e-07 29.5 20.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KII65962.1 - 1.3e-05 25.2 1.9 1.4e-05 25.1 0.8 1.8 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KII65962.1 - 7.3e-05 22.4 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Lipl32 PF12103.8 KII65962.1 - 0.059 13.0 0.7 0.11 12.2 0.7 1.4 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order ABC_tran PF00005.27 KII65962.1 - 0.091 13.3 2.6 0.12 12.9 0.0 2.2 2 1 0 2 2 2 0 ABC transporter Atg14 PF10186.9 KII65962.1 - 0.38 9.8 8.3 0.61 9.1 8.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1040 PF06288.13 KII65962.1 - 0.8 10.1 5.7 0.28 11.6 0.3 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1040) PFK PF00365.20 KII65964.1 - 3.4e-25 89.0 0.1 5.4e-12 45.6 0.0 2.1 2 0 0 2 2 2 2 Phosphofructokinase rve PF00665.26 KII65968.1 - 4.8e-25 88.1 0.0 1.3e-24 86.6 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65968.1 - 7.3e-11 42.0 0.6 7.3e-11 42.0 0.6 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII65968.1 - 4.2e-06 26.9 0.0 2.3e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 H2C2 zinc finger MLVIN_C PF18697.1 KII65968.1 - 0.0068 16.5 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII65968.1 - 0.0081 15.9 0.0 0.025 14.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 KII65969.1 - 7e-37 125.5 0.1 1.2e-36 124.7 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII65969.1 - 3.8e-36 123.6 0.0 7.1e-36 122.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII65969.1 - 1.2e-26 93.6 0.0 1.9e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII65969.1 - 2.3e-05 24.8 0.0 5.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII65969.1 - 2.4e-05 24.2 11.3 0.013 15.5 2.1 2.5 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII65969.1 - 0.022 15.1 0.0 0.067 13.5 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 KII65969.1 - 0.03 14.1 7.6 1.3 8.8 0.6 2.8 1 1 1 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 KII65969.1 - 0.034 14.8 0.1 0.07 13.8 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease RVP_2 PF08284.11 KII65969.1 - 0.04 13.7 0.1 0.086 12.6 0.1 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Spuma_A9PTase PF03539.14 KII65969.1 - 0.044 13.9 0.0 0.08 13.1 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_6 PF15288.6 KII65969.1 - 0.087 12.7 11.8 0.58 10.1 0.8 2.5 2 0 0 2 2 2 0 Zinc knuckle HpaB PF03241.13 KII65969.1 - 0.23 10.5 0.0 0.43 9.6 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal DDE_Tnp_IS1595 PF12762.7 KII65970.1 - 4.5e-06 26.7 0.0 5.5e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain RDD PF06271.12 KII65970.1 - 0.11 12.7 0.1 0.15 12.3 0.1 1.1 1 0 0 1 1 1 0 RDD family WD40 PF00400.32 KII65972.1 - 2.4e-22 78.8 3.0 5.9e-07 30.1 0.0 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII65972.1 - 0.0019 18.4 0.2 0.014 15.6 0.1 2.3 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KII65972.1 - 0.15 10.7 0.4 6.4 5.3 0.0 2.6 2 1 0 3 3 3 0 Nucleoporin Nup120/160 Trypan_PARP PF05887.11 KII65973.1 - 0.064 13.2 1.0 0.086 12.8 1.0 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Nkap_C PF06047.11 KII65974.1 - 0.00014 22.0 0.3 0.00033 20.7 0.1 1.7 2 0 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain FLYWCH PF04500.16 KII65975.1 - 8.1e-09 35.5 1.8 1.3e-08 34.9 1.8 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain GSHPx PF00255.19 KII65976.1 - 2.6e-24 84.9 0.1 5.1e-24 83.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione peroxidase YsaB PF13983.6 KII65976.1 - 0.2 11.9 0.0 0.57 10.5 0.0 1.8 1 1 1 2 2 2 0 YsaB-like lipoprotein SK_channel PF03530.14 KII65977.1 - 0.44 10.5 4.6 0.16 12.0 1.9 1.8 1 1 1 2 2 2 0 Calcium-activated SK potassium channel DUF2207 PF09972.9 KII65977.1 - 2.4 6.8 6.5 3 6.5 6.5 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2070 PF09843.9 KII65977.1 - 5.1 5.3 8.0 6.6 4.9 8.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HVSL PF09749.9 KII65978.1 - 2.2e-14 53.5 0.9 2.2e-10 40.4 0.2 2.1 1 1 1 2 2 2 2 Uncharacterised conserved protein tRNA_int_endo PF01974.17 KII65979.1 - 1.2e-15 57.3 0.0 2.2e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Arg_decarb_HB PF17810.1 KII65982.1 - 0.1 12.9 0.8 0.48 10.7 0.8 2.3 1 1 0 1 1 1 0 Arginine decarboxylase helical bundle domain DUF5582 PF17819.1 KII65982.1 - 0.15 12.5 8.0 0.21 12.0 7.6 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5582) EF-hand_1 PF00036.32 KII65985.1 - 4.8e-24 82.1 7.4 5.5e-06 25.6 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KII65985.1 - 1.8e-21 76.3 5.0 7.1e-13 48.8 0.7 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KII65985.1 - 2.2e-20 70.8 4.3 0.00016 21.3 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KII65985.1 - 4.3e-18 63.9 7.2 2.9e-05 23.3 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KII65985.1 - 1.9e-12 46.8 7.6 4.5e-05 23.2 0.3 4.5 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KII65985.1 - 1.2e-08 35.3 0.0 0.0027 18.0 0.0 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KII65985.1 - 2e-05 24.5 1.1 0.034 14.1 0.3 2.9 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KII65985.1 - 0.0018 18.5 0.0 0.75 10.2 0.0 3.0 3 1 0 3 3 3 1 EF-hand domain Toprim_2 PF13155.6 KII65985.1 - 0.0079 16.6 0.1 0.11 13.0 0.0 2.3 2 1 0 2 2 2 1 Toprim-like Dockerin_1 PF00404.18 KII65985.1 - 0.02 15.1 4.9 0.027 14.7 1.5 2.5 1 1 1 2 2 2 0 Dockerin type I domain Caleosin PF05042.13 KII65985.1 - 0.1 12.5 1.7 33 4.4 0.1 3.5 2 2 2 4 4 4 0 Caleosin related protein NYD-SP12_N PF15015.6 KII65986.1 - 0.18 10.2 0.1 0.23 9.8 0.1 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal WD40 PF00400.32 KII65987.1 - 1.9e-38 129.7 20.6 5.6e-09 36.5 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII65987.1 - 2.7e-11 43.6 0.2 0.005 17.1 0.0 4.2 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KII65987.1 - 0.0072 15.7 0.5 2 7.7 0.0 2.5 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 KII65987.1 - 0.019 13.6 4.2 2 6.9 0.2 3.5 3 1 0 4 4 4 0 Nucleoporin Nup120/160 Glyco_hydro_2_N PF02837.18 KII65989.1 - 0.091 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain UPF0154 PF03672.13 KII65989.1 - 0.14 12.2 0.1 0.23 11.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Ribosomal_L35Ae PF01247.18 KII65990.1 - 8.3e-32 109.2 0.5 9.9e-32 109.0 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 KII65990.1 - 1.2e-05 25.5 0.0 0.016 15.4 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Dna2 PF08696.11 KII65992.1 - 0.088 12.6 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 DNA replication factor Dna2 Catalase-rel PF06628.12 KII65993.1 - 0.052 13.8 0.1 6.6 7.0 0.0 2.9 3 0 0 3 3 3 0 Catalase-related immune-responsive DUF2096 PF09869.9 KII65994.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) rve PF00665.26 KII65995.1 - 1.5e-13 50.9 0.1 2.1e-13 50.5 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII65995.1 - 4.2e-13 49.2 0.2 7.5e-13 48.4 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII65995.1 - 0.0028 17.9 0.1 0.0053 16.9 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Zn_Tnp_IS1 PF03811.13 KII65995.1 - 0.068 12.9 0.3 0.16 11.7 0.3 1.5 1 0 0 1 1 1 0 InsA N-terminal domain DDE_3 PF13358.6 KII65996.1 - 1.9e-06 27.7 0.1 2.5e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Dimer_Tnp_hAT PF05699.14 KII65997.1 - 0.0017 18.1 0.2 0.0056 16.4 0.2 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Tetraspanin PF00335.20 KII66000.1 - 1.1e-13 51.4 14.2 1.5e-13 51.0 14.2 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF962 PF06127.11 KII66000.1 - 1 9.5 5.3 1.4 9.0 3.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF962) IRF PF00605.17 KII66004.1 - 0.042 14.1 0.0 0.05 13.9 0.0 1.2 1 0 0 1 1 1 0 Interferon regulatory factor transcription factor HTH_21 PF13276.6 KII66008.1 - 2.4e-07 30.8 0.2 6.3e-07 29.4 0.2 1.7 1 0 0 1 1 1 1 HTH-like domain rve PF00665.26 KII66008.1 - 0.03 14.5 0.0 0.058 13.6 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain dCMP_cyt_deam_1 PF00383.23 KII66009.1 - 4.6e-17 61.8 0.1 8.1e-17 61.0 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KII66009.1 - 1.8e-07 31.0 0.0 5.7e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 MafB19-like deaminase DUF5048 PF16467.5 KII66009.1 - 0.014 15.6 0.0 5.6 7.3 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5048) FlgO PF17680.1 KII66009.1 - 0.091 12.5 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 FlgO protein DUF1955 PF09205.10 KII66009.1 - 0.12 12.1 4.9 2.3 7.9 0.4 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1955) HTH_Tnp_1 PF01527.20 KII66010.1 - 6.2e-12 45.7 0.0 1e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Transposase LysM PF01476.20 KII66015.1 - 2.7e-07 30.6 0.0 2.7e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 LysM domain G_glu_transpept PF01019.21 KII66016.1 - 3e-25 89.0 0.0 3.3e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.21 KII66017.1 - 8.3e-85 285.5 0.0 9.3e-85 285.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Ribosomal_L6e PF01159.19 KII66021.1 - 5.1e-33 113.9 0.7 5.1e-33 113.9 0.7 2.0 2 0 0 2 2 2 1 Ribosomal protein L6e Cas_GSU0053 PF09617.10 KII66021.1 - 0.015 15.2 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) DDE_3 PF13358.6 KII66022.1 - 4.1e-09 36.4 0.2 4.6e-09 36.2 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Prp31_C PF09785.9 KII66023.1 - 2e-38 132.0 0.8 3.2e-38 131.3 0.8 1.3 1 0 0 1 1 1 1 Prp31 C terminal domain Nop PF01798.18 KII66023.1 - 2.5e-26 92.6 0.0 4.5e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin PGP_phosphatase PF09419.10 KII66023.1 - 0.15 11.7 0.1 0.28 10.8 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Nop PF01798.18 KII66024.1 - 7.1e-21 74.7 0.0 1.2e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin 2Fe-2S_thioredx PF01257.19 KII66025.1 - 2.1e-58 196.3 0.0 2.9e-58 195.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin RRP36 PF06102.12 KII66026.1 - 7.9e-30 104.0 30.9 8.6e-30 103.9 30.9 1.0 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 EIIBC-GUT_N PF03612.14 KII66026.1 - 2.7 7.7 6.6 5.2 6.8 6.6 1.6 1 1 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus zf-SNAP50_C PF12251.8 KII66027.1 - 8.8e-45 152.8 11.6 2e-44 151.7 11.6 1.6 1 1 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal F-box PF00646.33 KII66027.1 - 0.46 10.4 2.5 0.76 9.7 0.5 2.3 3 0 0 3 3 3 0 F-box domain MULE PF10551.9 KII66030.1 - 1.9e-11 44.3 0.1 2.6e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.17 KII66030.1 - 0.23 11.2 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Transposase Folate_rec PF03024.14 KII66031.1 - 2.3e-28 99.2 14.7 2.5e-28 99.1 14.7 1.0 1 0 0 1 1 1 1 Folate receptor family Zip PF02535.22 KII66032.1 - 3.4e-25 89.0 18.6 4e-21 75.6 6.8 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter Form_Nir_trans PF01226.17 KII66032.1 - 0.061 12.7 11.4 0.087 12.1 9.0 2.3 1 1 2 3 3 3 0 Formate/nitrite transporter Hydrolase_like PF13242.6 KII66033.1 - 3e-18 65.6 0.0 5.6e-18 64.8 0.0 1.5 1 1 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KII66033.1 - 1.1e-05 25.6 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KII66033.1 - 7.1e-05 23.2 0.0 8.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 KII66033.1 - 0.0074 15.9 0.4 0.021 14.5 0.1 1.7 1 1 1 2 2 2 1 Mitochondrial PGP phosphatase Sortilin_C PF15901.5 KII66034.1 - 8.6e-12 45.7 0.6 1.7e-11 44.8 0.6 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII66034.1 - 3.3e-09 36.0 0.1 1.1e-07 31.0 0.1 2.1 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII66034.1 - 0.00017 21.1 1.5 0.13 12.4 0.1 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat Prp19 PF08606.11 KII66036.1 - 0.033 14.2 0.7 0.3 11.1 0.1 2.3 2 0 0 2 2 2 0 Prp19/Pso4-like RIFIN PF02009.16 KII66038.1 - 0.0016 18.4 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Rifin RCR PF12273.8 KII66038.1 - 0.11 13.2 0.1 0.21 12.2 0.1 1.4 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Insulin_TMD PF17870.1 KII66038.1 - 0.3 11.2 2.2 0.49 10.5 2.2 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment ADAM17_MPD PF16698.5 KII66039.1 - 3.6e-05 24.0 7.2 3.6e-05 24.0 7.2 2.6 2 0 0 2 2 2 1 Membrane-proximal domain, switch, for ADAM17 RasGEF PF00617.19 KII66040.1 - 7.2e-37 127.3 6.9 8.8e-37 127.0 6.9 1.1 1 0 0 1 1 1 1 RasGEF domain TUSC2 PF15000.6 KII66040.1 - 0.022 15.0 0.1 0.04 14.2 0.1 1.4 1 0 0 1 1 1 0 Tumour suppressor candidate 2 DDE_3 PF13358.6 KII66041.1 - 2.4e-05 24.1 0.0 0.0014 18.4 0.0 2.3 2 0 0 2 2 2 2 DDE superfamily endonuclease PAX PF00292.18 KII66041.1 - 0.03 14.2 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 'Paired box' domain DUF4639 PF15479.6 KII66042.1 - 0.052 12.5 0.1 0.073 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) DUF4639 PF15479.6 KII66043.1 - 0.038 13.0 0.2 0.053 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) Ribosomal_S19e PF01090.19 KII66044.1 - 4e-44 149.6 0.0 4.6e-44 149.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_L16 PF00252.18 KII66046.1 - 8.4e-34 116.4 0.2 1e-33 116.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e YjhX_toxin PF09857.9 KII66046.1 - 0.12 12.4 0.0 0.36 10.8 0.0 1.8 2 0 0 2 2 2 0 Putative toxin of bacterial toxin-antitoxin pair Arfaptin PF06456.13 KII66048.1 - 3.6e-16 59.4 6.5 3.6e-16 59.4 6.5 1.6 2 0 0 2 2 2 1 Arfaptin-like domain End3 PF12761.7 KII66048.1 - 0.0016 18.6 6.8 0.0016 18.6 6.8 1.8 2 0 0 2 2 2 1 Actin cytoskeleton-regulatory complex protein END3 MT-A70 PF05063.14 KII66049.1 - 3.7e-24 85.6 0.0 7.1e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 MT-A70 PHD PF00628.29 KII66050.1 - 5.1e-07 29.5 28.9 6.1e-07 29.2 5.2 3.6 3 1 0 3 3 3 3 PHD-finger PHD_2 PF13831.6 KII66050.1 - 1.4e-05 24.5 1.3 1.4e-05 24.5 1.3 4.4 5 1 0 5 5 5 1 PHD-finger C1_1 PF00130.22 KII66050.1 - 0.0092 15.9 2.1 0.0092 15.9 2.1 4.2 3 1 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 KII66050.1 - 0.024 14.6 0.7 0.024 14.6 0.7 4.3 4 1 0 4 4 4 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 KII66050.1 - 0.097 12.3 0.3 0.097 12.3 0.3 3.5 4 0 0 4 4 4 0 PHD/FYVE-zinc-finger like domain UPF0547 PF10571.9 KII66050.1 - 0.25 11.5 0.1 0.25 11.5 0.1 3.9 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 DNA_RNApol_7kD PF03604.13 KII66050.1 - 1.8 8.3 0.0 1.8 8.3 0.0 4.4 3 1 1 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit Mito_carr PF00153.27 KII66051.1 - 4.6e-45 151.5 4.1 5.2e-19 68.0 0.2 3.2 1 1 2 3 3 3 3 Mitochondrial carrier protein Vps52 PF04129.12 KII66052.1 - 0.04 12.7 0.1 0.044 12.5 0.1 1.1 1 0 0 1 1 1 0 Vps52 / Sac2 family DDE_3 PF13358.6 KII66053.1 - 4.9e-14 52.3 0.0 5.7e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease YBD PF17725.1 KII66053.1 - 0.1 12.4 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 YAP binding domain RRM_1 PF00076.22 KII66054.1 - 1.5e-26 92.0 1.0 1.6e-11 43.8 0.0 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KII66054.1 - 0.00019 21.2 0.0 0.34 10.8 0.0 2.6 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 KII66054.1 - 0.14 12.3 0.0 3.9 7.7 0.0 2.6 2 1 0 2 2 2 0 RNA recognition motif Glycoprot_B_PH2 PF17417.2 KII66055.1 - 0.0088 16.4 0.1 0.021 15.1 0.1 1.6 1 0 0 1 1 1 1 Herpesvirus Glycoprotein B PH-like domain Glycolytic PF00274.19 KII66057.1 - 4.7e-151 502.5 0.0 5.2e-151 502.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I DDE_3 PF13358.6 KII66058.1 - 1.3e-08 34.7 0.0 2.9e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_hydro_47 PF01532.20 KII66059.1 - 9e-73 245.7 1.2 1.7e-72 244.8 1.2 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.22 KII66059.1 - 3.9e-08 33.2 0.0 7.9e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 PA domain Chal_sti_synt_C PF02797.15 KII66060.1 - 0.12 12.3 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Chalcone and stilbene synthases, C-terminal domain Ribonuc_red_sm PF00268.21 KII66061.1 - 3.9e-61 207.0 1.7 4.9e-61 206.6 1.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain NMT PF01233.19 KII66061.1 - 0.0008 19.3 0.2 0.0013 18.6 0.2 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain DUF4744 PF15918.5 KII66061.1 - 0.11 13.3 0.0 0.2 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) Ribonuc_red_sm PF00268.21 KII66062.1 - 6.2e-31 107.9 0.0 6.9e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF3891 PF13030.6 KII66063.1 - 0.95 9.2 8.0 7.2 6.3 1.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3891) Cas6b_C PF17262.2 KII66066.1 - 0.05 13.7 0.6 0.078 13.1 0.6 1.2 1 0 0 1 1 1 0 Cas6b C-terminal domain Choline_kinase PF01633.20 KII66070.1 - 6.1e-50 169.8 5.3 7.6e-50 169.4 1.9 2.5 2 1 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 KII66070.1 - 6e-09 36.2 0.0 9.4e-09 35.5 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Endotoxin_N PF03945.14 KII66071.1 - 0.042 13.6 0.6 0.2 11.3 0.2 1.9 1 1 1 2 2 2 0 delta endotoxin, N-terminal domain DUF4476 PF14771.6 KII66075.1 - 0.0022 18.3 0.1 0.0053 17.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) AAR2 PF05282.11 KII66076.1 - 2.4e-65 221.3 0.5 3.8e-65 220.6 0.5 1.2 1 0 0 1 1 1 1 AAR2 protein Methyltransf_31 PF13847.6 KII66076.1 - 0.0014 18.4 0.3 0.0032 17.3 0.3 1.6 1 0 0 1 1 1 1 Methyltransferase domain DUF4611 PF15387.6 KII66076.1 - 0.022 15.0 1.4 0.057 13.6 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Colicin-DNase PF12639.7 KII66076.1 - 0.085 13.7 2.4 0.094 13.5 0.0 2.2 3 0 0 3 3 3 0 DNase/tRNase domain of colicin-like bacteriocin Fcf1 PF04900.12 KII66077.1 - 2.8e-34 117.5 1.1 2.8e-34 117.5 1.1 1.5 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 KII66077.1 - 7.7e-14 52.0 0.0 1.4e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 PIN like domain Histone PF00125.24 KII66078.1 - 0.12 12.7 0.4 0.18 12.1 0.4 1.6 1 1 0 1 1 1 0 Core histone H2A/H2B/H3/H4 DUF5621 PF18532.1 KII66079.1 - 0.051 13.5 0.8 1.7 8.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5621) Amidase_5 PF05382.13 KII66079.1 - 0.058 13.3 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage peptidoglycan hydrolase Glyco_hydro_42C PF08533.10 KII66079.1 - 0.074 12.8 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain Sortilin_C PF15901.5 KII66081.1 - 5.5e-08 33.3 0.0 7e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Ldl_recept_a PF00057.18 KII66083.1 - 5.9e-29 100.0 55.7 1.8e-12 47.2 11.1 3.4 3 1 0 3 3 3 3 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII66084.1 - 2.2e-09 37.4 30.0 0.00012 22.3 11.7 2.5 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 KII66084.1 - 0.011 15.6 12.7 0.015 15.1 12.7 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like DUF1576 PF07613.11 KII66084.1 - 0.025 14.1 0.2 0.041 13.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1576) bMG6 PF17962.1 KII66084.1 - 0.075 13.2 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Bacterial macroglobulin domain 6 MG4 PF17789.1 KII66084.1 - 0.12 12.5 0.1 0.26 11.5 0.1 1.5 1 0 0 1 1 1 0 Macroglobulin domain MG4 DUF2407_C PF13373.6 KII66084.1 - 0.14 12.4 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain Glyco_transf_43 PF03360.16 KII66087.1 - 1.2e-24 87.3 0.2 6.5e-24 84.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 43 SF3A2 PF16835.5 KII66088.1 - 3e-35 120.4 1.5 4.6e-35 119.9 1.5 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 KII66088.1 - 1.3e-06 28.5 1.2 1.3e-06 28.5 1.2 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 KII66088.1 - 0.00011 22.1 1.9 0.00017 21.5 1.9 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 KII66088.1 - 0.4 10.3 3.3 0.67 9.6 3.3 1.3 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Arf PF00025.21 KII66089.1 - 4.8e-26 91.3 0.0 5.8e-26 91.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KII66089.1 - 9.8e-13 48.0 0.0 1.1e-12 47.8 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KII66089.1 - 2e-12 46.9 0.0 2.3e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KII66089.1 - 7.3e-09 35.9 0.0 1.7e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KII66089.1 - 6.7e-05 22.9 0.0 9.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KII66089.1 - 7.7e-05 22.0 0.1 0.004 16.4 0.0 2.5 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 KII66089.1 - 0.0023 17.4 0.0 0.0024 17.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 KII66089.1 - 0.0092 16.3 0.0 0.018 15.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 KII66089.1 - 0.096 12.5 0.0 2.8 7.6 0.0 2.3 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 KII66089.1 - 0.19 12.1 0.0 0.43 10.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain CD34_antigen PF06365.12 KII66090.1 - 0.019 14.5 0.3 0.02 14.5 0.3 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family Insulin_TMD PF17870.1 KII66090.1 - 0.09 12.9 1.1 0.14 12.2 1.1 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DDE_Tnp_IS1595 PF12762.7 KII66091.1 - 6.8e-06 26.2 0.2 0.0035 17.4 0.0 2.7 2 2 0 2 2 2 2 ISXO2-like transposase domain PRD_Mga PF08270.11 KII66093.1 - 0.0025 17.5 0.4 0.0049 16.6 0.4 1.5 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) PRD domain RIFIN PF02009.16 KII66095.1 - 2.4e-05 24.4 2.2 2.6e-05 24.3 2.2 1.1 1 0 0 1 1 1 1 Rifin ODV-E18 PF10717.9 KII66095.1 - 0.051 13.4 1.1 0.096 12.6 1.1 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Sigma_reg_N PF13800.6 KII66095.1 - 0.17 12.2 7.6 0.14 12.5 6.4 1.5 1 1 1 2 2 2 0 Sigma factor regulator N-terminal TMEM154 PF15102.6 KII66095.1 - 0.35 10.8 5.4 0.5 10.3 5.3 1.4 1 1 0 1 1 1 0 TMEM154 protein family DDE_3 PF13358.6 KII66096.1 - 1.8e-14 53.7 0.1 2.5e-14 53.3 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease UDPGT PF00201.18 KII66096.1 - 0.022 13.6 0.0 0.022 13.6 0.0 1.0 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase DUF3975 PF13126.6 KII66097.1 - 0.053 14.0 1.5 0.39 11.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3975) Serpin PF00079.20 KII66100.1 - 2.9e-43 148.6 2.5 3.3e-43 148.4 2.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ferlin_C PF16165.5 KII66101.1 - 0.0071 16.3 0.8 0.011 15.7 0.1 1.6 1 1 1 2 2 2 1 Ferlin C-terminus T4SS_CagC PF16943.5 KII66101.1 - 0.012 15.7 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 Cag pathogenicity island, type IV secretory system Terminase_3C PF17288.2 KII66101.1 - 0.018 15.5 0.2 0.027 14.9 0.2 1.3 1 0 0 1 1 1 0 Terminase RNAseH like domain Involucrin_N PF10583.9 KII66101.1 - 0.21 12.2 0.0 0.34 11.5 0.0 1.3 1 0 0 1 1 1 0 Involucrin of squamous epithelia N-terminus PurA PF04845.13 KII66103.1 - 1.5e-08 34.3 2.4 0.018 14.4 0.1 2.9 1 1 1 3 3 3 3 PurA ssDNA and RNA-binding protein PIF1 PF05970.14 KII66105.1 - 8.4e-42 143.6 0.1 1.2e-41 143.1 0.1 1.2 1 0 0 1 1 1 1 PIF1-like helicase Peptidase_M73 PF12389.8 KII66105.1 - 0.057 13.2 1.3 3.8 7.3 0.1 2.6 3 0 0 3 3 3 0 Camelysin metallo-endopeptidase Kelch_6 PF13964.6 KII66109.1 - 9.2e-27 92.4 16.7 1.7e-05 25.0 0.2 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KII66109.1 - 1.2e-19 70.0 22.1 1.6e-06 28.0 0.9 6.7 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KII66109.1 - 6.1e-16 57.7 12.9 7.1e-05 22.6 0.1 6.2 6 1 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII66109.1 - 5.9e-13 48.7 10.7 0.0027 17.9 0.0 6.4 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII66109.1 - 1.2e-11 44.0 31.2 0.001 18.6 0.7 7.1 7 2 0 7 7 7 4 Kelch motif Kelch_5 PF13854.6 KII66109.1 - 6.8e-11 41.9 16.5 4.2e-07 29.8 0.0 5.9 6 0 0 6 6 6 3 Kelch motif zf-UDP PF14569.6 KII66110.1 - 0.095 12.8 2.3 0.18 11.9 2.3 1.5 1 1 0 1 1 1 0 Zinc-binding RING-finger Kelch_6 PF13964.6 KII66112.1 - 9.7e-19 67.0 9.0 1.8e-06 28.0 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII66112.1 - 7e-14 51.7 1.3 0.0002 21.6 0.1 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII66112.1 - 7.3e-13 48.3 3.2 0.00036 20.5 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII66112.1 - 1.8e-12 46.6 10.5 1.1e-05 24.9 0.4 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII66112.1 - 2.7e-08 33.6 6.2 0.018 15.0 0.6 3.4 3 1 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KII66112.1 - 0.00021 21.1 4.4 0.28 11.2 0.4 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 KII66113.1 - 4e-28 96.7 20.2 3.5e-06 27.1 0.2 6.4 5 1 1 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KII66113.1 - 1e-20 73.5 13.0 4.7e-05 23.3 0.0 6.3 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 KII66113.1 - 5.9e-19 67.4 20.8 9.6e-05 21.9 0.3 6.9 6 1 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KII66113.1 - 3.1e-17 62.4 9.6 0.00078 19.7 0.0 7.3 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KII66113.1 - 1.4e-13 50.5 18.0 0.0022 17.9 0.0 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.15 KII66113.1 - 2.4e-10 39.9 21.7 0.13 12.2 0.1 6.6 6 1 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KII66114.1 - 3.2e-18 65.3 16.8 2.4e-06 27.6 0.4 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KII66114.1 - 1.7e-16 60.0 10.8 2.4e-06 27.4 0.1 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII66114.1 - 1.4e-13 50.2 15.5 4.9e-05 22.8 0.4 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 KII66114.1 - 7.7e-13 48.1 19.3 1.6e-06 27.9 0.7 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 KII66114.1 - 1.6e-10 40.5 14.6 0.00037 20.3 0.3 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 KII66114.1 - 2.9e-06 27.4 15.5 0.7 10.2 0.1 6.5 7 0 0 7 7 7 3 Galactose oxidase, central domain DDE_3 PF13358.6 KII66115.1 - 0.023 14.5 0.0 0.03 14.1 0.0 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease DCAF15_WD40 PF14939.6 KII66116.1 - 0.094 12.4 0.4 0.12 12.0 0.4 1.2 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat VPS53_C PF16854.5 KII66117.1 - 0.0089 15.9 0.0 0.037 13.9 0.0 1.9 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 53 C-terminus E1_DerP2_DerF2 PF02221.15 KII66119.1 - 7.2e-05 23.2 0.0 9.2e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 ML domain E1_DerP2_DerF2 PF02221.15 KII66120.1 - 0.011 16.2 0.1 0.013 15.9 0.1 1.1 1 0 0 1 1 1 0 ML domain DDE_3 PF13358.6 KII66122.1 - 0.00037 20.3 0.2 0.00055 19.7 0.2 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease LIM PF00412.22 KII66123.1 - 7.2e-26 90.2 46.0 6.7e-12 45.5 8.2 3.2 3 0 0 3 3 3 3 LIM domain PDZ PF00595.24 KII66123.1 - 3.8e-10 40.0 0.0 6.5e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII66123.1 - 1.3e-07 31.3 0.0 2.1e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII66123.1 - 0.099 13.0 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 PDZ domain IMUP PF15761.5 KII66123.1 - 0.4 11.4 2.9 0.87 10.3 2.9 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SAP PF02037.27 KII66125.1 - 2.8e-10 39.7 2.7 5.1e-10 38.9 2.7 1.4 1 0 0 1 1 1 1 SAP domain AAA_33 PF13671.6 KII66125.1 - 4.2e-10 39.9 0.0 1e-09 38.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain SPRY PF00622.28 KII66125.1 - 7e-06 26.1 0.3 1.7e-05 24.9 0.3 1.6 1 0 0 1 1 1 1 SPRY domain ANAPC2 PF08672.11 KII66128.1 - 0.036 14.6 0.1 0.12 12.9 0.1 1.9 1 0 0 1 1 1 0 Anaphase promoting complex (APC) subunit 2 PLAT PF01477.23 KII66129.1 - 3.4e-08 34.1 0.1 6.4e-08 33.2 0.1 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain F5_F8_type_C PF00754.25 KII66129.1 - 7.4e-08 32.6 0.0 1.4e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain F5_F8_type_C PF00754.25 KII66130.1 - 1.6e-32 112.3 0.0 1.6e-18 67.1 0.0 2.2 2 0 0 2 2 2 2 F5/8 type C domain Laminin_G_3 PF13385.6 KII66131.1 - 4.1e-19 69.2 0.0 7.3e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily TSP_1 PF00090.19 KII66131.1 - 3e-11 43.3 18.0 1.8e-06 28.0 5.0 2.4 2 0 0 2 2 2 2 Thrombospondin type 1 domain Pentaxin PF00354.17 KII66131.1 - 0.00027 20.7 0.0 0.0076 15.9 0.0 2.3 2 0 0 2 2 2 1 Pentaxin family Apis_Csd PF11671.8 KII66132.1 - 0.18 11.8 1.1 0.24 11.4 0.3 1.6 1 1 1 2 2 2 0 Complementary sex determiner protein zf-C2H2_jaz PF12171.8 KII66133.1 - 1.2e-06 28.7 16.4 2.1e-05 24.7 8.5 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KII66133.1 - 0.00015 22.1 6.6 0.00015 22.1 6.6 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KII66133.1 - 0.0004 20.7 21.4 0.012 16.0 4.6 3.3 2 1 1 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 KII66133.1 - 0.0078 17.0 18.8 0.076 13.9 2.1 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KII66133.1 - 0.38 11.4 11.6 0.6 10.8 7.5 2.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Thioredoxin PF00085.20 KII66134.1 - 5.6e-20 71.3 0.1 6.6e-20 71.0 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.16 KII66134.1 - 7.1e-06 25.8 0.1 8.1e-06 25.6 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_9 PF14595.6 KII66134.1 - 1.4e-05 24.9 0.2 1.7e-05 24.6 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KII66134.1 - 0.00028 21.3 0.3 0.0019 18.6 0.3 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 KII66134.1 - 0.0033 16.8 0.1 0.0033 16.8 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family KaiB PF07689.12 KII66134.1 - 0.021 14.5 0.1 0.037 13.8 0.0 1.6 2 0 0 2 2 2 0 KaiB domain TrbC_Ftype PF09673.10 KII66134.1 - 0.049 13.7 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein DUF836 PF05768.14 KII66134.1 - 0.071 13.5 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) SLC35F PF06027.12 KII66135.1 - 1.1e-31 110.5 27.2 1.3e-31 110.2 27.2 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 KII66135.1 - 1e-09 37.9 10.4 1e-09 37.9 10.4 2.3 2 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 KII66135.1 - 0.0049 17.0 33.2 0.023 14.9 13.9 2.3 2 0 0 2 2 2 2 EamA-like transporter family DUF485 PF04341.12 KII66135.1 - 0.29 11.1 0.1 0.29 11.1 0.1 3.7 1 1 2 4 4 4 0 Protein of unknown function, DUF485 Cys_rich_FGFR PF00839.17 KII66137.1 - 0.075 13.2 0.3 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Cysteine rich repeat DDE_Tnp_IS1595 PF12762.7 KII66138.1 - 7.4e-05 22.8 0.7 0.0001 22.3 0.1 1.5 2 0 0 2 2 2 1 ISXO2-like transposase domain RT_RNaseH_2 PF17919.1 KII66139.1 - 1.2e-09 38.1 0.0 2.5e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase HMG_box PF00505.19 KII66140.1 - 5.4e-36 122.8 14.1 8.1e-22 77.4 1.7 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KII66140.1 - 3.9e-29 101.1 16.0 2.2e-17 63.4 3.0 2.4 2 0 0 2 2 2 2 HMG-box domain Protamine_like PF06382.11 KII66140.1 - 9.3e-05 22.6 10.7 0.0037 17.5 5.1 2.3 1 1 1 2 2 2 2 Protamine and protamine like HMG_box_5 PF14887.6 KII66140.1 - 0.0024 17.8 2.8 0.0024 17.8 2.8 2.5 2 1 0 2 2 2 2 HMG (high mobility group) box 5 COX4 PF02936.14 KII66140.1 - 0.21 11.6 4.9 5.7 7.0 0.6 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV FAM60A PF15396.6 KII66140.1 - 3 7.8 21.4 1.1 9.3 8.9 2.1 1 1 1 2 2 2 0 Protein Family FAM60A SUFU_C PF12470.8 KII66140.1 - 4.5 7.3 9.6 29 4.6 9.6 2.0 1 1 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain SIS PF01380.22 KII66141.1 - 1.6e-42 144.5 0.2 1.4e-24 86.4 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KII66141.1 - 1.9e-12 47.6 0.0 3.8e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KII66141.1 - 7.8e-06 25.0 0.0 1.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_7 PF13537.6 KII66141.1 - 1.5e-05 24.9 0.0 4.2e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 KII66141.1 - 0.15 12.1 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 SIS domain CLASP_N PF12348.8 KII66143.1 - 6.1e-07 29.2 0.1 0.0001 21.9 0.1 2.1 2 0 0 2 2 2 2 CLASP N terminal Cnd1 PF12717.7 KII66143.1 - 5.1e-06 26.6 0.6 0.00039 20.5 0.2 2.4 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KII66143.1 - 0.0012 18.9 0.7 4.4 7.8 0.1 4.2 4 0 0 4 4 4 1 HEAT repeat MMS19_N PF14500.6 KII66143.1 - 0.0032 17.1 0.1 0.031 13.9 0.1 2.2 2 1 1 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II TAN PF11640.8 KII66143.1 - 0.013 15.6 0.3 0.078 13.1 0.3 2.2 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair DUF1837 PF08878.11 KII66143.1 - 0.038 13.8 0.0 2.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1837) Adaptin_N PF01602.20 KII66143.1 - 0.047 12.2 0.5 0.13 10.8 0.5 1.7 1 1 0 1 1 1 0 Adaptin N terminal region SEA PF01390.20 KII66144.1 - 5.1e-07 29.7 0.3 1e-06 28.8 0.0 1.6 2 0 0 2 2 2 1 SEA domain DUF4738 PF15889.5 KII66144.1 - 0.1 12.5 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4738) Kelch_6 PF13964.6 KII66145.1 - 7e-21 73.8 12.3 2.9e-05 24.2 0.0 6.7 5 2 1 6 6 6 6 Kelch motif Kelch_1 PF01344.25 KII66145.1 - 5.1e-19 67.6 13.0 2.1e-05 24.0 1.9 5.7 5 1 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KII66145.1 - 1.3e-17 63.0 8.3 0.00017 21.4 0.2 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII66145.1 - 1e-14 54.2 21.0 0.0011 18.9 0.2 6.9 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII66145.1 - 1.6e-12 47.1 7.3 0.04 13.9 0.1 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 KII66145.1 - 9.1e-10 38.6 12.3 0.0048 17.2 0.0 6.2 6 1 0 6 6 6 3 Galactose oxidase, central domain PAX PF00292.18 KII66146.1 - 8.1e-06 25.8 0.2 1.1e-05 25.4 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.6 KII66146.1 - 0.01 15.8 0.1 0.013 15.5 0.1 1.2 1 0 0 1 1 1 0 Winged helix-turn helix HTH_38 PF13936.6 KII66146.1 - 0.017 14.9 0.3 0.028 14.2 0.3 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1323 PF07037.11 KII66146.1 - 0.019 15.4 0.0 0.027 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) HTH_23 PF13384.6 KII66146.1 - 0.036 13.9 0.0 0.058 13.2 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DDE_3 PF13358.6 KII66147.1 - 3.5e-05 23.6 0.1 8.3e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease SIS PF01380.22 KII66148.1 - 1e-33 116.0 0.1 2e-25 89.2 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KII66148.1 - 7.6e-13 48.8 0.0 1.7e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KII66148.1 - 4.6e-07 29.0 0.0 7.6e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_7 PF13537.6 KII66148.1 - 7e-06 26.0 0.0 1.7e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 KII66148.1 - 0.011 15.7 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 SIS domain Acyltransf_C PF16076.5 KII66149.1 - 1.2e-15 57.3 1.9 1.4e-15 57.1 0.1 2.0 2 0 0 2 2 2 1 Acyltransferase C-terminus Acyltransferase PF01553.21 KII66149.1 - 4.2e-12 45.8 0.0 6.6e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase DUF2340 PF10209.9 KII66150.1 - 9.7e-22 77.7 0.0 1.1e-21 77.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) PI3_PI4_kinase PF00454.27 KII66151.1 - 1.8e-32 113.1 0.1 5.6e-32 111.5 0.1 1.8 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase NDUF_B7 PF05676.13 KII66151.1 - 0.026 14.2 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF4135 PF13575.6 KII66151.1 - 0.048 13.0 0.0 0.06 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) PI3K_C2 PF00792.24 KII66152.1 - 3.9e-11 43.0 0.0 8.7e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3Ka PF00613.20 KII66152.1 - 8e-10 38.4 0.4 2.4e-09 36.9 0.5 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_p85B PF02192.16 KII66152.1 - 0.00085 19.0 1.4 0.02 14.6 0.3 3.2 3 0 0 3 3 3 1 PI3-kinase family, p85-binding domain Pannexin_like PF12534.8 KII66153.1 - 5.5e-08 32.3 2.7 1.3e-05 24.5 0.0 2.5 1 1 1 2 2 2 2 Pannexin-like TM region of LRRC8 OTU PF02338.19 KII66153.1 - 0.013 16.0 0.0 0.033 14.7 0.0 1.7 2 0 0 2 2 2 0 OTU-like cysteine protease Sigma_reg_N PF13800.6 KII66153.1 - 2.2 8.6 6.4 3.4 8.0 0.1 3.1 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Ribosomal_L3 PF00297.22 KII66154.1 - 4.5e-133 443.8 4.6 5.1e-133 443.6 4.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 DUF1664 PF07889.12 KII66155.1 - 7.8e-07 29.2 1.5 0.014 15.4 0.4 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) DUF948 PF06103.11 KII66155.1 - 9.2e-06 25.8 7.5 0.083 13.2 0.3 3.3 1 1 2 3 3 3 2 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 KII66155.1 - 0.0014 18.7 6.2 0.067 13.2 0.5 2.8 1 1 2 3 3 3 2 Laminin Domain II Bacillus_HBL PF05791.11 KII66155.1 - 0.0023 17.8 3.4 0.52 10.1 0.0 2.2 2 0 0 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) Thioredoxin PF00085.20 KII66155.1 - 0.0045 17.0 0.0 0.015 15.3 0.0 2.0 2 0 0 2 2 1 1 Thioredoxin Baculo_PEP_C PF04513.12 KII66155.1 - 0.012 15.6 10.1 0.012 15.6 10.1 2.9 2 1 1 3 3 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Col_cuticle_N PF01484.17 KII66155.1 - 0.035 14.2 0.2 0.15 12.1 0.2 2.1 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain BLOC1_2 PF10046.9 KII66155.1 - 0.049 13.9 1.8 3 8.2 0.3 2.9 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MCPsignal PF00015.21 KII66155.1 - 0.084 12.7 0.4 1.1 9.0 0.1 2.3 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain OSCP PF00213.18 KII66155.1 - 0.093 12.9 2.3 2.4 8.3 0.2 2.4 1 1 1 2 2 2 0 ATP synthase delta (OSCP) subunit NPV_P10 PF05531.12 KII66155.1 - 0.12 12.9 12.1 2.6 8.6 0.8 3.5 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein Thioredoxin_6 PF13848.6 KII66155.1 - 0.14 12.1 2.1 0.41 10.5 0.5 2.0 2 0 0 2 2 2 0 Thioredoxin-like domain Sec8_exocyst PF04048.14 KII66155.1 - 0.34 10.8 5.2 1.9 8.4 0.5 2.5 1 1 0 2 2 2 0 Sec8 exocyst complex component specific domain Fib_alpha PF08702.10 KII66155.1 - 0.61 10.3 6.4 2.2 8.5 0.9 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CHDCT2 PF08074.11 KII66155.1 - 0.92 9.7 3.1 7.3 6.7 0.1 2.9 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain Mce4_CUP1 PF11887.8 KII66155.1 - 1.3 8.4 5.3 7.7 5.9 1.3 2.5 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative AATF-Che1 PF13339.6 KII66155.1 - 1.7 9.3 4.9 62 4.3 4.6 2.8 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor DASH_Dam1 PF08653.10 KII66155.1 - 2 8.3 6.6 34 4.4 0.6 4.1 2 1 3 5 5 5 0 DASH complex subunit Dam1 DASH_Duo1 PF08651.10 KII66155.1 - 4.1 7.2 7.2 11 5.8 0.3 3.4 2 1 2 4 4 4 0 DASH complex subunit Duo1 CAP_N PF01213.19 KII66155.1 - 5.7 6.3 5.3 5.6 6.4 0.1 2.5 1 1 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DASH_Dad4 PF08650.10 KII66155.1 - 6.9 6.7 9.8 14 5.7 0.9 3.1 2 1 1 3 3 3 0 DASH complex subunit Dad4 Pkinase PF00069.25 KII66156.1 - 8.2e-08 31.9 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Aa_trans PF01490.18 KII66157.1 - 3.7e-36 124.7 20.3 4.8e-36 124.3 20.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MFS_1_like PF12832.7 KII66158.1 - 1.4e-34 119.6 27.7 1.8e-34 119.3 27.7 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 KII66158.1 - 2e-22 79.6 42.8 1.7e-15 56.9 22.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KII66158.1 - 0.0018 16.9 19.9 0.0018 16.9 19.9 2.7 1 1 1 2 2 2 1 MFS/sugar transport protein Sugar_tr PF00083.24 KII66158.1 - 0.041 12.8 31.2 0.085 11.7 2.8 3.4 2 2 0 2 2 2 0 Sugar (and other) transporter OATP PF03137.20 KII66158.1 - 0.67 8.2 18.8 0.016 13.5 4.2 2.9 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family CS PF04969.16 KII66161.1 - 4.8e-09 37.1 0.6 4.8e-09 37.1 0.6 1.7 2 0 0 2 2 2 1 CS domain SGS PF05002.15 KII66161.1 - 0.00033 20.7 2.2 0.00079 19.5 2.2 1.7 1 0 0 1 1 1 1 SGS domain Siah-Interact_N PF09032.11 KII66161.1 - 0.018 15.3 0.7 0.057 13.7 0.3 2.0 2 0 0 2 2 2 0 Siah interacting protein, N terminal Ca_chan_IQ PF08763.11 KII66161.1 - 0.12 12.6 2.4 0.44 10.8 0.2 2.7 3 0 0 3 3 3 0 Voltage gated calcium channel IQ domain PAP2_C PF14360.6 KII66162.1 - 9.1e-20 71.0 15.4 1.6e-19 70.2 15.4 1.4 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PAP2 PF01569.21 KII66162.1 - 8.2e-10 38.6 5.5 1.1e-09 38.1 5.5 1.2 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 KII66162.1 - 0.00046 19.9 4.7 0.00062 19.5 4.7 1.2 1 0 0 1 1 1 1 PAP2 superfamily UAA PF08449.11 KII66163.1 - 4.5e-40 137.7 15.8 5.1e-40 137.6 15.8 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KII66163.1 - 8.8e-12 45.4 13.6 8.8e-12 45.4 13.6 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KII66163.1 - 4.7e-06 26.2 11.4 6.4e-06 25.7 11.4 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family CRT-like PF08627.10 KII66163.1 - 0.0045 16.0 13.9 0.012 14.6 2.4 2.1 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like DUF962 PF06127.11 KII66163.1 - 0.0066 16.5 0.8 0.013 15.6 0.2 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF962) DUF373 PF04123.13 KII66163.1 - 0.68 9.3 10.2 1.7 8.0 10.6 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF373) 7tm_1 PF00001.21 KII66165.1 - 9.4e-09 35.0 4.0 1.1e-08 34.7 4.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KII66165.1 - 3.2e-07 30.0 8.5 4e-07 29.7 8.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 KII66166.1 - 5.9e-14 52.0 15.0 8.4e-14 51.5 15.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cortexin PF11057.8 KII66166.1 - 0.088 12.7 0.1 0.088 12.7 0.1 2.9 4 0 0 4 4 4 0 Cortexin of kidney Vpu PF00558.19 KII66166.1 - 0.81 9.5 11.9 0.21 11.4 5.3 2.3 2 0 0 2 2 2 0 Vpu protein Ferlin_C PF16165.5 KII66166.1 - 2.5 8.0 5.9 0.45 10.4 1.0 2.2 2 0 0 2 2 2 0 Ferlin C-terminus 7tm_1 PF00001.21 KII66167.1 - 3.1e-12 46.4 13.9 4.3e-12 45.9 13.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FLYWCH PF04500.16 KII66168.1 - 0.00036 20.6 0.4 0.00066 19.7 0.4 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain Tetraspanin PF00335.20 KII66170.1 - 0.00076 19.2 14.7 0.0029 17.4 14.7 1.9 1 1 0 1 1 1 1 Tetraspanin family STT3 PF02516.14 KII66170.1 - 0.51 9.2 12.7 0.79 8.6 12.7 1.3 1 1 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit Caa3_CtaG PF09678.10 KII66170.1 - 3.1 7.2 9.4 0.23 10.9 3.2 2.0 2 1 0 2 2 2 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) 7tm_1 PF00001.21 KII66171.1 - 1.5e-06 27.7 1.7 1.8e-06 27.5 1.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KII66172.1 - 5.6e-05 22.6 4.7 6.9e-05 22.3 4.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KII66173.1 - 3.7e-13 49.4 6.2 5.1e-13 49.0 6.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KII66173.1 - 1.9e-06 27.5 12.2 2.1e-06 27.3 12.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KII66173.1 - 0.003 17.4 0.4 0.0045 16.8 0.4 1.4 1 0 0 1 1 1 1 Olfactory receptor UPF0182 PF03699.13 KII66173.1 - 1 7.4 8.0 1.2 7.2 8.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) HTH_32 PF13565.6 KII66174.1 - 5.2e-05 23.8 0.3 0.0013 19.3 0.2 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 KII66174.1 - 0.00036 20.1 0.0 0.00071 19.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix MetOD1 PF18546.1 KII66174.1 - 0.013 15.5 1.2 0.053 13.5 0.1 1.9 1 1 0 2 2 2 0 Metanogen output domain 1 PAX PF00292.18 KII66174.1 - 0.032 14.2 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 'Paired box' domain Mnd1 PF03962.15 KII66174.1 - 0.041 14.2 0.0 0.082 13.2 0.0 1.5 1 0 0 1 1 1 0 Mnd1 HTH domain 7tm_1 PF00001.21 KII66175.1 - 9e-12 44.9 8.6 2.1e-11 43.7 8.5 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KII66175.1 - 5.1e-05 22.8 13.4 5.9e-05 22.6 13.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv AMP-binding PF00501.28 KII66177.1 - 4.6e-49 167.2 0.0 5.6e-49 166.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme LID PF17916.1 KII66177.1 - 1.7 8.4 4.1 0.48 10.1 0.2 2.0 2 0 0 2 2 2 0 LIM interaction domain (LID) DUF2939 PF11159.8 KII66178.1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2939) UCH PF00443.29 KII66179.1 - 2.2e-24 86.3 0.2 2.7e-24 86.1 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Sdh_cyt PF01127.22 KII66180.1 - 1.7e-23 82.9 5.1 2.4e-23 82.5 5.1 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Ribosomal_L3 PF00297.22 KII66181.1 - 8e-74 248.8 0.4 9.9e-74 248.5 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 AhpC-TSA PF00578.21 KII66182.1 - 4.1e-20 71.9 0.0 5.6e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KII66182.1 - 5.8e-05 22.8 0.0 7.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin DUF5094 PF17015.5 KII66182.1 - 0.084 13.0 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) DUF4078 PF13300.6 KII66183.1 - 1.6e-09 37.9 15.5 2.1e-09 37.6 11.4 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF4078) Nckap1 PF09735.9 KII66185.1 - 6.3e-29 100.7 4.5 7e-28 97.2 4.5 1.9 1 1 0 1 1 1 1 Membrane-associated apoptosis protein LEM PF03020.15 KII66186.1 - 1.2e-15 56.7 0.3 3.3e-15 55.3 0.3 1.8 1 0 0 1 1 1 1 LEM domain MSC PF09402.10 KII66186.1 - 3e-07 30.2 3.2 6.3e-07 29.2 3.2 1.6 1 1 0 1 1 1 1 Man1-Src1p-C-terminal domain DUF2207 PF09972.9 KII66186.1 - 0.0098 14.7 0.1 0.013 14.3 0.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Chromate_transp PF02417.15 KII66186.1 - 0.042 14.0 0.5 0.068 13.3 0.5 1.3 1 0 0 1 1 1 0 Chromate transporter Brix PF04427.18 KII66187.1 - 1.7e-29 103.4 0.8 2.1e-29 103.0 0.8 1.1 1 0 0 1 1 1 1 Brix domain TCR PF03638.15 KII66188.1 - 7.2e-23 80.6 53.2 5e-12 45.9 24.4 2.4 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 KII66188.1 - 0.028 14.6 17.8 0.028 14.6 17.8 2.9 2 1 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 Glyco_transf_10 PF00852.19 KII66189.1 - 7.3e-35 120.3 1.2 1.3e-34 119.5 1.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DUF1759 PF03564.15 KII66191.1 - 3.2e-05 23.9 0.0 3.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Adap_comp_sub PF00928.21 KII66192.1 - 0.021 14.2 0.1 0.033 13.6 0.1 1.3 1 0 0 1 1 1 0 Adaptor complexes medium subunit family WD40 PF00400.32 KII66193.1 - 2.4e-13 50.3 2.6 0.00087 20.1 0.1 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat eIF2A PF08662.11 KII66193.1 - 1.3e-06 28.4 0.0 0.047 13.6 0.0 2.4 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 KII66193.1 - 0.0059 16.9 0.0 40 4.6 0.0 4.2 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Cpn60_TCP1 PF00118.24 KII66194.1 - 2e-12 46.5 0.0 3e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PIP5K PF01504.18 KII66195.1 - 2e-32 112.5 11.2 5.2e-25 88.2 5.4 2.9 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase DUF4573 PF15140.6 KII66195.1 - 0.0029 17.4 0.5 0.026 14.3 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4573) 7tm_1 PF00001.21 KII66196.1 - 1.5e-24 86.8 19.2 2.2e-24 86.2 19.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KII66196.1 - 8e-05 22.4 22.9 8e-05 22.4 22.9 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KII66196.1 - 0.00019 20.9 29.0 0.00026 20.4 29.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx FLILHELTA PF10306.9 KII66196.1 - 0.022 15.1 3.1 0.056 13.9 0.1 2.8 3 0 0 3 3 3 0 Hypothetical protein FLILHELTA HHV-5_US34A PF17087.5 KII66196.1 - 0.13 12.5 1.1 0.46 10.7 1.1 1.9 1 0 0 1 1 1 0 Herpesvirus US34A protein family DUF4064 PF13273.6 KII66196.1 - 6.8 7.0 17.6 5 7.5 0.6 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) Ldl_recept_a PF00057.18 KII66197.1 - 1e-11 44.8 17.8 3.1e-09 36.9 7.0 2.8 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A HIG_1_N PF04588.13 KII66197.1 - 0.0012 19.1 0.8 0.0041 17.3 0.1 2.0 2 0 0 2 2 2 1 Hypoxia induced protein conserved region Sortilin_C PF15901.5 KII66198.1 - 1.8e-13 51.2 2.7 2.8e-13 50.6 2.7 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII66198.1 - 0.00013 20.9 0.8 0.00033 19.6 0.1 1.8 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII66198.1 - 0.16 12.1 4.7 2.5 8.5 0.1 3.4 3 0 0 3 3 3 0 BNR/Asp-box repeat rve PF00665.26 KII66199.1 - 1.8e-19 70.1 0.7 5.4e-19 68.5 0.3 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII66199.1 - 3.5e-17 62.2 0.0 1.2e-16 60.5 0.0 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 KII66199.1 - 4e-06 27.1 0.0 1.2e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 KII66199.1 - 1.8e-05 24.9 0.0 4.7e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII66199.1 - 0.00012 21.8 0.0 0.00029 20.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF4129 PF13559.6 KII66199.1 - 0.021 15.1 0.0 0.051 13.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) HAT PF02184.16 KII66200.1 - 1.8e-33 114.1 71.3 4.8e-17 61.6 5.2 14.0 14 2 0 14 14 14 9 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 KII66200.1 - 4.8e-19 67.4 12.5 0.69 10.9 0.0 11.7 7 3 6 13 13 12 5 Tetratricopeptide repeat TPR_17 PF13431.6 KII66200.1 - 4.6e-09 36.0 3.2 9.4e-05 22.5 0.1 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 KII66200.1 - 4.8e-08 33.4 0.0 0.49 10.9 0.0 6.1 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII66200.1 - 4.3e-07 29.6 7.9 1.4 9.2 0.0 8.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 KII66200.1 - 2.3e-05 24.7 9.2 3.9 8.3 0.0 8.9 9 1 1 10 10 10 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII66200.1 - 0.00011 22.1 3.6 7.6 7.0 0.2 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 KII66200.1 - 0.00026 21.1 4.8 5.9 7.1 0.2 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KII66200.1 - 0.0045 17.0 24.6 0.55 10.2 0.2 7.1 6 3 0 6 6 6 3 Mad3/BUB1 homology region 1 U3_assoc_6 PF08640.11 KII66200.1 - 0.032 14.3 23.1 0.38 10.9 1.1 7.1 5 2 2 7 7 7 0 U3 small nucleolar RNA-associated protein 6 TPR_7 PF13176.6 KII66200.1 - 0.75 10.0 6.6 18 5.7 0.0 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat HEAT_2 PF13646.6 KII66201.1 - 0.00016 22.0 0.0 4 7.9 0.0 3.9 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 KII66201.1 - 0.0002 21.4 0.0 2.2 8.8 0.0 4.5 4 0 0 4 4 4 1 HEAT repeat Arm PF00514.23 KII66201.1 - 0.0018 18.2 1.0 10 6.4 0.0 4.3 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KII66201.1 - 0.0053 16.8 0.1 5 7.1 0.0 3.1 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KII66201.1 - 0.0063 17.0 0.0 0.24 12.0 0.0 2.9 3 0 0 3 3 3 1 HEAT-like repeat HTH_32 PF13565.6 KII66202.1 - 0.042 14.5 0.0 0.055 14.1 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain R3H PF01424.22 KII66202.1 - 0.057 13.4 0.2 0.15 12.1 0.1 1.7 2 0 0 2 2 2 0 R3H domain MFS_1 PF07690.16 KII66203.1 - 8e-20 71.1 23.1 1.2e-19 70.5 23.1 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily RhoGAP PF00620.27 KII66204.1 - 9.9e-23 80.7 0.0 1.5e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain FANCD2OS PF15124.6 KII66205.1 - 0.029 14.6 0.2 0.029 14.6 0.2 2.1 2 1 0 2 2 2 0 FANCD2 opposite strand protein PK PF00224.21 KII66206.1 - 9.8e-92 307.5 4.2 1.2e-91 307.2 4.2 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KII66206.1 - 2e-29 102.2 0.4 8.2e-29 100.2 0.1 2.1 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain Amastin PF07344.11 KII66207.1 - 0.024 14.5 4.8 0.024 14.5 4.8 2.2 1 1 1 2 2 2 0 Amastin surface glycoprotein WBP-1 PF11669.8 KII66207.1 - 0.051 14.2 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 WW domain-binding protein 1 TMEM107 PF14995.6 KII66207.1 - 0.4 11.1 8.1 0.93 9.9 8.1 1.7 1 1 0 1 1 1 0 Transmembrane protein Tetraspanin PF00335.20 KII66207.1 - 0.47 10.1 11.5 0.52 10.0 11.5 1.3 1 1 0 1 1 1 0 Tetraspanin family I-EGF_1 PF18372.1 KII66208.1 - 3e-06 27.2 13.7 3e-06 27.2 13.7 4.1 4 0 0 4 4 4 1 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 KII66208.1 - 3.9e-06 27.1 42.1 1e-05 25.8 17.4 4.9 3 2 2 5 5 5 2 EGF-like domain EGF_Tenascin PF18720.1 KII66208.1 - 0.061 13.4 21.5 0.086 12.9 4.5 2.8 2 0 0 2 2 2 0 Tenascin EGF domain SH2 PF00017.24 KII66209.1 - 0.059 13.5 0.0 0.099 12.8 0.0 1.4 1 0 0 1 1 1 0 SH2 domain zf-C2H2_4 PF13894.6 KII66210.1 - 8.7e-16 57.3 65.0 0.00096 19.8 0.3 8.1 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KII66210.1 - 3e-11 43.3 49.5 0.0011 19.2 1.3 7.7 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KII66210.1 - 1.2e-09 38.0 75.9 0.0031 17.9 0.4 8.2 8 1 0 8 8 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KII66210.1 - 5.1e-08 33.0 58.4 0.00097 19.5 4.6 10.1 10 1 0 10 10 10 4 Zinc-finger double domain zf-met PF12874.7 KII66210.1 - 0.00039 20.7 29.6 0.054 13.9 0.8 6.4 6 0 0 6 6 6 4 Zinc-finger of C2H2 type RIG-I_C-RD PF11648.8 KII66210.1 - 0.047 13.9 0.6 0.047 13.9 0.6 4.3 4 1 1 5 5 5 0 C-terminal domain of RIG-I DDA1 PF10172.9 KII66210.1 - 0.26 11.6 2.8 1 9.7 0.1 3.2 3 0 0 3 3 3 0 Det1 complexing ubiquitin ligase zinc_ribbon_15 PF17032.5 KII66210.1 - 0.53 11.1 25.2 1.6 9.5 0.2 4.9 4 1 1 5 5 5 0 zinc-ribbon family ARS2 PF04959.13 KII66210.1 - 1.8 8.9 16.7 0.75 10.1 0.7 3.8 1 1 3 4 4 4 0 Arsenite-resistance protein 2 zf-C2H2_9 PF16293.5 KII66210.1 - 1.9 8.4 12.3 3.5 7.6 1.3 4.8 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) GAGA PF09237.11 KII66210.1 - 2.3 8.1 0.0 2.3 8.1 0.0 6.1 6 1 1 7 7 7 0 GAGA factor Desulfoferrod_N PF06397.12 KII66210.1 - 5.2 6.8 6.7 13 5.5 1.0 3.0 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Ribosomal_S27 PF01599.19 KII66211.1 - 1.2e-21 76.6 3.6 1.7e-20 72.9 3.6 2.4 2 0 0 2 2 2 1 Ribosomal protein S27a ubiquitin PF00240.23 KII66211.1 - 4.9e-08 32.6 0.1 4.9e-08 32.6 0.1 2.0 2 1 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 KII66211.1 - 7.1e-07 29.0 0.7 9.7e-07 28.5 0.1 1.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF3377 PF11857.8 KII66212.1 - 0.0016 18.3 0.1 0.0036 17.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) TMEM154 PF15102.6 KII66212.1 - 0.0038 17.1 0.2 0.0054 16.6 0.2 1.3 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 KII66212.1 - 0.014 15.7 1.2 0.015 15.5 0.0 1.7 2 0 0 2 2 2 0 Orf78 (ac78) DUF4448 PF14610.6 KII66212.1 - 0.049 13.4 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Vpu PF00558.19 KII66212.1 - 3.3 7.5 4.6 2.8 7.8 2.3 2.0 2 0 0 2 2 2 0 Vpu protein DUF4519 PF15012.6 KII66212.1 - 4.9 7.4 5.5 0.66 10.2 1.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) TMEM154 PF15102.6 KII66213.1 - 5.7e-05 23.0 0.1 0.00011 22.1 0.1 1.5 1 0 0 1 1 1 1 TMEM154 protein family RIFIN PF02009.16 KII66213.1 - 0.00039 20.4 0.0 0.00042 20.3 0.0 1.2 1 0 0 1 1 1 1 Rifin DUF3377 PF11857.8 KII66213.1 - 0.028 14.3 0.1 0.078 12.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Orf78 PF06024.12 KII66213.1 - 0.034 14.5 5.5 0.037 14.3 1.9 2.4 2 1 0 2 2 2 0 Orf78 (ac78) DUF4448 PF14610.6 KII66213.1 - 0.075 12.8 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) ADD_ATRX PF17981.1 KII66213.1 - 0.13 12.2 0.1 0.51 10.2 0.0 1.9 2 0 0 2 2 2 0 Cysteine Rich ADD domain DUF4519 PF15012.6 KII66213.1 - 0.24 11.6 1.0 0.52 10.5 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) HTH_23 PF13384.6 KII66215.1 - 0.0042 16.8 0.1 0.015 15.0 0.1 1.9 2 0 0 2 2 2 1 Homeodomain-like domain GlutR_dimer PF00745.20 KII66215.1 - 0.11 13.0 0.1 0.18 12.2 0.1 1.3 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain Serpin PF00079.20 KII66218.1 - 3e-56 191.3 1.6 3.8e-56 191.0 1.6 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cornichon PF03311.14 KII66218.1 - 0.082 13.2 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 Cornichon protein Sortilin-Vps10 PF15902.5 KII66222.1 - 1.3e-10 40.7 0.8 2.5e-10 39.8 0.8 1.4 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII66222.1 - 9e-08 31.0 1.3 1.1 9.5 0.0 4.1 4 0 0 4 4 4 3 BNR/Asp-box repeat Mo-co_dimer PF03404.16 KII66222.1 - 0.025 14.6 0.0 18 5.4 0.0 3.0 2 1 1 3 3 3 0 Mo-co oxidoreductase dimerisation domain UCH PF00443.29 KII66223.1 - 0.12 11.9 5.2 0.023 14.2 0.7 2.0 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Sortilin-Vps10 PF15902.5 KII66225.1 - 7.1e-12 44.9 2.1 5e-06 25.6 0.1 2.4 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII66225.1 - 1.7e-07 30.2 3.7 1.5 9.1 0.1 6.2 5 0 0 5 5 5 2 BNR/Asp-box repeat Ldl_recept_a PF00057.18 KII66225.1 - 3.3e-05 24.0 9.0 3.3e-05 24.0 9.0 3.6 4 0 0 4 4 4 1 Low-density lipoprotein receptor domain class A BRCT_2 PF16589.5 KII66225.1 - 0.034 14.5 0.0 19 5.8 0.0 2.7 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain BLYB PF05289.11 KII66225.1 - 0.071 13.3 0.3 6.6 7.0 0.0 2.9 2 0 0 2 2 2 0 Borrelia hemolysin accessory protein Sortilin-Vps10 PF15902.5 KII66227.1 - 5.2e-09 35.4 0.3 2.9e-08 32.9 0.3 1.9 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII66227.1 - 4.1e-07 29.0 3.2 0.086 12.9 0.1 4.1 4 0 0 4 4 4 3 BNR/Asp-box repeat Sortilin_C PF15901.5 KII66227.1 - 0.0053 17.1 0.6 0.011 16.1 0.6 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR_6 PF15899.5 KII66227.1 - 0.025 14.6 0.0 14 6.1 0.0 2.9 2 0 0 2 2 2 0 BNR-Asp box repeat Mo-co_dimer PF03404.16 KII66227.1 - 0.1 12.6 0.0 3.2 7.8 0.0 2.8 3 0 0 3 3 3 0 Mo-co oxidoreductase dimerisation domain RT_RNaseH_2 PF17919.1 KII66228.1 - 9.6e-06 25.6 0.0 2.1e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII66228.1 - 1.1e-05 25.7 0.0 1.7e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII66228.1 - 0.083 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Integrase zinc binding domain DnaI_N PF07319.11 KII66229.1 - 0.003 18.2 0.3 0.0037 17.9 0.3 1.2 1 0 0 1 1 1 1 Primosomal protein DnaI N-terminus GW PF13457.6 KII66230.1 - 0.029 15.0 3.1 0.094 13.3 3.1 1.9 1 1 0 1 1 1 0 GW (Gly-Tryp) dipeptide domain Adeno_E3_CR1 PF02440.15 KII66234.1 - 0.013 15.2 4.5 0.39 10.5 0.8 2.2 1 1 1 2 2 2 0 Adenovirus E3 region protein CR1 RT_RNaseH_2 PF17919.1 KII66234.1 - 0.037 14.1 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase SRPRB PF09439.10 KII66236.1 - 4.4e-20 71.9 0.4 5.5e-20 71.5 0.4 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 KII66236.1 - 1.1e-08 34.7 0.1 1.4e-08 34.4 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KII66236.1 - 0.00014 21.9 0.0 0.00029 20.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KII66236.1 - 0.0031 17.1 0.2 0.004 16.7 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IstB_IS21 PF01695.17 KII66236.1 - 0.0032 17.2 0.2 2.4 7.9 0.1 2.4 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA PF00004.29 KII66236.1 - 0.0056 17.1 1.0 0.024 15.1 1.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF1500 PF07389.12 KII66236.1 - 0.045 13.8 0.2 0.09 12.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1500) ResIII PF04851.15 KII66236.1 - 0.052 13.6 0.1 1.3 9.0 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_33 PF13671.6 KII66236.1 - 0.087 13.0 0.0 0.15 12.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain DUF4897 PF16238.5 KII66237.1 - 0.0011 18.9 0.8 0.9 9.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4897) DUF4954 PF16314.5 KII66237.1 - 0.0049 15.1 0.0 0.0056 14.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) CCT_2 PF09425.10 KII66237.1 - 0.11 12.4 0.6 0.24 11.3 0.6 1.5 1 0 0 1 1 1 0 Divergent CCT motif GST_C_3 PF14497.6 KII66237.1 - 0.21 11.8 3.9 0.92 9.7 0.2 2.6 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain Med31 PF05669.12 KII66238.1 - 0.085 12.9 0.0 0.16 12.0 0.0 1.5 1 1 0 1 1 1 0 SOH1 E1_FCCH PF16190.5 KII66240.1 - 0.024 14.8 0.1 0.093 12.9 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-activating enzyme E1 FCCH domain NARP1 PF12569.8 KII66240.1 - 0.067 12.1 0.8 0.081 11.8 0.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CH PF00307.31 KII66241.1 - 8.6e-25 87.0 0.1 1.4e-24 86.3 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 KII66241.1 - 5.4e-11 41.9 4.3 1.1e-10 41.0 4.3 1.5 1 0 0 1 1 1 1 Calponin family repeat CAMSAP_CH PF11971.8 KII66241.1 - 0.00043 20.1 0.0 0.00069 19.4 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.11 KII66241.1 - 0.00064 19.9 0.7 0.0011 19.2 0.7 1.3 1 0 0 1 1 1 1 CDC24 Calponin Macro PF01661.21 KII66243.1 - 5.8e-05 23.1 0.0 9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Macro domain DUF3291 PF11695.8 KII66243.1 - 0.12 12.0 0.1 12 5.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3291) Ldl_recept_a PF00057.18 KII66246.1 - 2.4e-34 117.2 113.3 1e-09 38.4 10.0 7.7 7 1 0 7 7 7 6 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 KII66246.1 - 0.00013 22.2 3.8 0.00013 22.2 3.8 6.1 6 1 0 6 6 6 1 Coagulation Factor Xa inhibitory site Sortilin-Vps10 PF15902.5 KII66247.1 - 8.9e-19 67.6 0.2 1.3e-18 67.0 0.2 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII66247.1 - 1.7e-18 67.5 4.1 3.6e-18 66.5 4.1 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII66247.1 - 5.1e-05 22.7 8.6 0.038 14.0 1.0 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF3990 PF13151.6 KII66247.1 - 0.012 15.3 0.2 0.052 13.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3990) BNR_6 PF15899.5 KII66247.1 - 4.5 7.6 5.8 11 6.4 0.1 3.5 5 0 0 5 5 5 0 BNR-Asp box repeat Antistasin PF02822.14 KII66247.1 - 6.6 7.5 7.6 2.7 8.7 2.3 2.9 3 0 0 3 3 3 0 Antistasin family Phage_tail_T PF06223.12 KII66248.1 - 0.05 14.1 0.6 0.076 13.5 0.6 1.3 1 0 0 1 1 1 0 Minor tail protein T DDE_3 PF13358.6 KII66249.1 - 7.2e-07 29.1 0.0 1.5e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease CENP-B_N PF04218.13 KII66249.1 - 0.0013 18.3 0.0 0.0029 17.2 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Glycos_transf_2 PF00535.26 KII66250.1 - 9.5e-06 25.5 0.0 1.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KII66250.1 - 0.00014 21.8 0.0 0.00024 21.1 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KII66250.1 - 0.0022 17.9 0.0 0.0026 17.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_5 PF13712.6 KII66250.1 - 0.019 14.7 0.2 0.021 14.5 0.2 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family SnoaL_2 PF12680.7 KII66253.1 - 2.2e-07 31.5 0.0 3.4e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 KII66253.1 - 0.084 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase DUF4440 PF14534.6 KII66253.1 - 0.11 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) MarR PF01047.22 KII66254.1 - 6.7e-11 41.9 0.0 1.6e-10 40.7 0.0 1.7 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 KII66254.1 - 2.6e-07 31.1 0.0 4.6e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR_2 PF12802.7 KII66254.1 - 3.4e-07 30.1 0.0 6.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 KII66254.1 - 0.00019 21.2 0.0 0.00033 20.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.6 KII66254.1 - 0.00037 20.6 0.0 0.00073 19.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_45 PF14947.6 KII66254.1 - 0.0014 18.6 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_IclR PF09339.10 KII66254.1 - 0.0085 15.9 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.6 KII66254.1 - 0.037 13.6 0.0 0.096 12.3 0.0 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 KII66254.1 - 0.058 13.4 0.0 0.17 11.9 0.0 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_20 PF12840.7 KII66254.1 - 0.063 13.4 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain YjcQ PF09639.10 KII66254.1 - 0.081 13.1 0.1 0.46 10.7 0.1 2.1 1 1 1 2 2 2 0 YjcQ protein MqsR_toxin PF15723.5 KII66254.1 - 0.092 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Motility quorum-sensing regulator, toxin of MqsA DUF2513 PF10711.9 KII66254.1 - 0.11 12.8 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) HTH_5 PF01022.20 KII66254.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family rve PF00665.26 KII66255.1 - 1.7e-08 34.7 0.0 4.5e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII66255.1 - 0.0011 18.7 0.4 0.0053 16.5 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain zf-CCHC_2 PF13696.6 KII66256.1 - 0.0051 16.6 0.7 0.0051 16.6 0.7 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 KII66256.1 - 0.018 15.1 1.7 0.018 15.1 1.7 2.7 3 0 0 3 3 3 0 Zinc knuckle Retrotrans_gag PF03732.17 KII66256.1 - 0.026 14.8 0.0 0.059 13.7 0.0 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein zinc-ribbons_6 PF07191.12 KII66256.1 - 0.049 13.6 6.6 0.63 10.1 0.0 2.5 2 1 0 2 2 2 0 zinc-ribbons Gag_p24 PF00607.20 KII66256.1 - 0.089 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) DUF2852 PF11014.8 KII66256.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) zf-CCHC_4 PF14392.6 KII66256.1 - 0.28 11.0 9.1 0.9 9.3 1.4 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 KII66256.1 - 0.8 9.7 7.3 0.76 9.8 5.6 1.8 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 KII66258.1 - 1.3e-25 89.9 0.0 2.5e-25 89.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII66258.1 - 8e-05 22.3 0.0 0.00022 21.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII66258.1 - 0.087 13.0 1.0 0.58 10.4 0.0 2.3 3 0 0 3 3 3 0 DDE domain Peptidase_S37 PF05576.11 KII66258.1 - 0.09 11.4 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 PS-10 peptidase S37 DUF2812 PF11193.8 KII66258.1 - 0.23 11.7 2.6 4.5 7.5 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2812) TssO PF17561.2 KII66260.1 - 0.13 12.3 2.0 1.6 8.8 0.2 2.3 1 1 1 2 2 2 0 Type VI secretion system, TssO Piwi PF02171.17 KII66263.1 - 9.5e-65 218.8 0.8 2e-64 217.8 0.8 1.5 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 KII66263.1 - 3.1e-10 40.0 0.6 7.1e-10 38.8 0.6 1.6 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 KII66263.1 - 0.012 15.9 0.0 0.036 14.4 0.0 1.8 1 0 0 1 1 1 0 Argonaute linker 2 domain Anticodon_1 PF08264.13 KII66263.1 - 0.077 13.0 0.3 0.58 10.1 0.1 2.5 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA DUF4964 PF16334.5 KII66263.1 - 0.1 12.2 0.1 0.28 10.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4964) DNA_ligase_ZBD PF03119.16 KII66264.1 - 0.27 11.3 0.8 1.2 9.3 0.3 2.1 1 1 1 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain DDE_3 PF13358.6 KII66265.1 - 1.6e-10 41.0 0.1 2.9e-10 40.1 0.1 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease Adap_comp_sub PF00928.21 KII66265.1 - 0.081 12.3 0.0 0.099 12.0 0.0 1.1 1 0 0 1 1 1 0 Adaptor complexes medium subunit family ACAS_N PF16177.5 KII66266.1 - 5.8e-07 29.3 0.3 1.2e-06 28.4 0.3 1.5 1 1 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding PF00501.28 KII66266.1 - 0.003 16.2 0.0 0.0036 16.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Hexapep PF00132.24 KII66267.1 - 8.9e-06 25.2 10.0 0.00014 21.4 1.6 3.5 2 1 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) FAD_binding_4 PF01565.23 KII66268.1 - 1.6e-18 66.8 0.0 1.9e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 KII66269.1 - 2.1e-09 37.6 0.1 5.6e-06 26.4 0.0 2.1 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase BBE PF08031.12 KII66269.1 - 0.00053 20.0 0.4 0.0014 18.7 0.2 1.8 1 1 0 1 1 1 1 Berberine and berberine like DUF3375 PF11855.8 KII66270.1 - 0.037 12.9 1.5 0.051 12.5 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) DMPK_coil PF08826.10 KII66270.1 - 0.16 12.1 5.4 7 6.8 0.4 2.5 1 1 1 2 2 2 0 DMPK coiled coil domain like VPS11_C PF12451.8 KII66270.1 - 0.47 10.7 0.1 0.47 10.7 0.1 2.7 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal TMF_DNA_bd PF12329.8 KII66270.1 - 0.49 10.4 7.5 0.12 12.4 3.0 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Dynamin_N PF00350.23 KII66271.1 - 2.9e-06 27.4 1.8 7e-06 26.2 0.0 2.5 2 1 1 3 3 3 1 Dynamin family PKcGMP_CC PF16808.5 KII66271.1 - 1.6 8.7 6.2 2.2 8.2 0.1 3.1 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase KxDL PF10241.9 KII66271.1 - 2.8 8.3 6.0 25 5.2 3.9 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein BTB_2 PF02214.22 KII66272.1 - 1.6e-09 38.0 0.0 3.6e-09 36.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain AA_permease_2 PF13520.6 KII66273.1 - 3.4e-38 131.6 40.9 4.1e-38 131.3 40.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII66273.1 - 7.7e-20 70.9 37.1 9.8e-20 70.6 37.1 1.2 1 0 0 1 1 1 1 Amino acid permease SieB PF14163.6 KII66273.1 - 4.2 6.8 6.1 2.9 7.4 1.4 2.7 2 0 0 2 2 2 0 Super-infection exclusion protein B FAM60A PF15396.6 KII66274.1 - 9.1e-07 29.1 0.1 9.1e-07 29.1 0.1 1.4 2 0 0 2 2 2 1 Protein Family FAM60A SNARE PF05739.19 KII66275.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 SNARE domain FixQ PF05545.11 KII66275.1 - 0.24 11.4 4.2 0.53 10.3 4.2 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Annexin PF00191.20 KII66276.1 - 0.0058 16.7 0.9 1.8 8.7 0.1 2.3 2 0 0 2 2 2 2 Annexin Flu_B_NS1 PF02942.14 KII66277.1 - 0.018 14.1 0.4 0.024 13.7 0.4 1.1 1 0 0 1 1 1 0 Influenza B non-structural protein (NS1) HTH_10 PF04967.12 KII66285.1 - 0.017 14.9 0.1 0.032 14.0 0.1 1.4 1 0 0 1 1 1 0 HTH DNA binding domain Bot1p PF12298.8 KII66285.1 - 0.023 14.9 0.4 0.026 14.7 0.4 1.1 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein HTH_11 PF08279.12 KII66285.1 - 0.06 13.3 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 HTH domain HTH_36 PF13730.6 KII66285.1 - 0.067 13.2 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 KII66285.1 - 0.087 12.3 0.1 0.22 11.0 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_DeoR PF08220.12 KII66285.1 - 0.12 12.1 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain EGF_2 PF07974.13 KII66286.1 - 0.012 15.9 13.3 0.012 15.9 13.3 2.5 2 1 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 KII66287.1 - 0.0059 17.0 14.6 0.0059 17.0 14.6 2.8 3 0 0 3 3 3 1 EGF-like domain TGase_elicitor PF16683.5 KII66287.1 - 0.012 14.4 2.9 0.017 13.9 2.9 1.2 1 0 0 1 1 1 0 Transglutaminase elicitor VEGF_C PF14554.6 KII66287.1 - 0.56 10.3 10.2 1.6 8.9 0.1 3.0 2 1 1 3 3 3 0 VEGF heparin-binding domain EGF_MSP1_1 PF12946.7 KII66287.1 - 3.4 7.8 15.4 0.07 13.2 5.5 2.8 1 1 2 3 3 3 0 MSP1 EGF domain 1 ABC_tran PF00005.27 KII66289.1 - 7.8e-46 156.0 0.2 7.2e-29 101.0 0.1 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KII66289.1 - 7.7e-40 137.3 50.2 7.8e-21 74.9 21.9 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 KII66289.1 - 5.6e-09 35.8 0.1 0.00074 19.0 0.1 3.8 2 2 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KII66289.1 - 1.5e-05 25.0 1.5 5.9 6.6 0.0 4.4 2 2 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 KII66289.1 - 0.00013 20.9 0.9 0.00053 18.9 0.1 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_16 PF13191.6 KII66289.1 - 0.00034 21.0 0.0 1.3 9.4 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain T2SSE PF00437.20 KII66289.1 - 0.00085 18.5 0.1 0.11 11.6 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 KII66289.1 - 0.00094 19.7 0.1 1.5 9.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 KII66289.1 - 0.001 19.1 0.0 1 9.4 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 KII66289.1 - 0.0027 17.4 2.4 0.11 12.2 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_24 PF13479.6 KII66289.1 - 0.0045 16.7 0.1 0.073 12.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain SH3_1 PF00018.28 KII66289.1 - 0.0085 15.7 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KII66289.1 - 0.011 15.4 0.0 0.037 13.7 0.0 1.9 1 0 0 1 1 1 0 Variant SH3 domain Dynamin_N PF00350.23 KII66289.1 - 0.012 15.7 0.2 0.47 10.5 0.0 2.6 2 0 0 2 2 2 0 Dynamin family AAA_7 PF12775.7 KII66289.1 - 0.013 15.1 0.2 2.3 7.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 KII66289.1 - 0.03 14.6 0.2 6 7.1 0.2 3.1 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 KII66289.1 - 0.045 12.9 0.0 3.4 6.8 0.0 2.5 2 1 0 2 2 2 0 NB-ARC domain DUF87 PF01935.17 KII66289.1 - 0.054 13.6 0.5 0.14 12.2 0.1 1.9 2 0 0 2 2 1 0 Helicase HerA, central domain FKBP_N_2 PF18023.1 KII66289.1 - 0.068 13.3 0.3 0.18 11.9 0.3 1.6 1 0 0 1 1 1 0 BDBT FKBP like N-terminal Sigma54_activat PF00158.26 KII66289.1 - 0.099 12.3 0.0 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Roc PF08477.13 KII66289.1 - 0.11 12.8 0.8 11 6.3 0.0 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 KII66289.1 - 0.15 11.8 0.5 1.2 8.9 0.1 2.4 2 1 0 2 2 2 0 DEAD/DEAH box helicase FtsK_SpoIIIE PF01580.18 KII66289.1 - 0.19 11.0 0.3 19 4.5 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family NTPase_1 PF03266.15 KII66289.1 - 0.2 11.5 0.9 0.49 10.3 0.0 2.0 2 0 0 2 2 2 0 NTPase Mago_nashi PF02792.14 KII66290.1 - 0.023 14.8 1.6 0.028 14.5 1.6 1.1 1 0 0 1 1 1 0 Mago nashi protein DUF1754 PF08555.10 KII66290.1 - 0.029 15.1 16.2 0.47 11.3 16.2 2.0 1 1 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) RRM_1 PF00076.22 KII66292.1 - 7.6e-13 48.1 0.0 1.3e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 KII66292.1 - 0.00066 20.2 0.2 0.00066 20.2 0.2 2.5 3 0 0 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 NeA_P2 PF12312.8 KII66292.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein RRM_occluded PF16842.5 KII66292.1 - 0.13 12.1 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif DDE_Tnp_IS1595 PF12762.7 KII66294.1 - 1.5e-19 70.5 0.0 2e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain zf-C2H2_12 PF18658.1 KII66295.1 - 0.044 13.4 0.1 0.094 12.3 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger C2H2-type rve PF00665.26 KII66297.1 - 1.3e-12 47.9 0.0 1.9e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII66297.1 - 0.0016 18.2 0.1 0.0028 17.4 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Nucleo_P87 PF07267.11 KII66297.1 - 0.014 14.3 0.1 0.015 14.2 0.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RT_RNaseH_2 PF17919.1 KII66298.1 - 1.5e-33 114.8 0.0 3.9e-33 113.4 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII66298.1 - 2.2e-32 111.5 0.0 6.4e-32 110.0 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII66298.1 - 7e-11 42.1 0.1 1.3e-10 41.2 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 KII66299.1 - 1.1e-07 31.6 0.1 5.8e-07 29.3 0.0 2.2 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII66299.1 - 1.9e-05 25.2 0.0 3.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII66299.1 - 0.00021 21.8 0.0 0.00042 20.9 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 KII66299.1 - 0.00022 21.0 0.0 0.00044 20.0 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2B PF12384.8 KII66299.1 - 0.004 16.7 1.6 0.087 12.4 0.2 2.9 2 1 1 3 3 3 1 Ty3 transposon peptidase RVP PF00077.20 KII66299.1 - 0.026 14.8 0.0 0.09 13.1 0.0 1.9 1 1 0 1 1 1 0 Retroviral aspartyl protease Arf PF00025.21 KII66299.1 - 0.039 13.4 0.1 0.073 12.5 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Peptidase_S11 PF00768.20 KII66303.1 - 0.18 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Rib_hydrolayse PF02267.17 KII66304.1 - 0.054 12.9 0.4 0.11 11.9 0.2 1.6 1 1 0 1 1 1 0 ADP-ribosyl cyclase Pentapeptide_4 PF13599.6 KII66309.1 - 0.0068 16.6 0.4 0.017 15.3 0.4 1.6 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 KII66309.1 - 0.015 15.4 1.4 0.12 12.5 1.4 2.0 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF4738 PF15889.5 KII66309.1 - 0.067 13.0 1.4 0.094 12.6 1.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4738) BRX PF08381.11 KII66309.1 - 6.6 6.2 7.8 12 5.3 0.9 2.6 2 1 0 2 2 2 0 Transcription factor regulating root and shoot growth via Pin3 RVT_1 PF00078.27 KII66312.1 - 7.8e-08 32.1 0.0 0.00085 18.9 0.0 2.2 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII66312.1 - 1.1e-07 31.8 0.0 3.1e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase DUF5478 PF17572.2 KII66312.1 - 0.089 12.9 0.8 16 5.7 0.1 3.3 3 1 0 3 3 3 0 Family of unknown function (DUF5478) Sortilin_C PF15901.5 KII66314.1 - 9.9e-09 35.8 1.8 1.7e-08 35.0 1.8 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII66314.1 - 6.2e-07 28.6 2.2 2.4e-06 26.6 2.2 1.9 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII66314.1 - 0.17 12.0 0.2 0.17 12.0 0.2 3.6 4 0 0 4 4 4 0 BNR/Asp-box repeat RRM_1 PF00076.22 KII66315.1 - 7.1e-11 41.8 0.2 3.2e-10 39.7 0.1 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 KII66315.1 - 1.8e-06 27.8 1.7 1.8e-06 27.8 1.7 2.3 2 0 0 2 2 2 1 Zinc finger domain Torus PF16131.5 KII66315.1 - 1.4e-05 25.7 0.0 2.7e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Torus domain zf-CCCH PF00642.24 KII66315.1 - 0.00022 21.0 1.4 0.00022 21.0 1.4 2.7 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nup35_RRM_2 PF14605.6 KII66315.1 - 0.00057 19.8 0.1 0.0012 18.8 0.1 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-CCCH_4 PF18044.1 KII66315.1 - 0.002 17.9 1.8 0.0045 16.8 1.8 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger RRM_3 PF08777.11 KII66315.1 - 0.0024 17.9 0.0 0.041 13.9 0.0 2.3 2 0 0 2 2 2 1 RNA binding motif zf-CCCH_3 PF15663.5 KII66315.1 - 0.005 17.0 0.1 0.019 15.2 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 KII66315.1 - 0.0084 16.5 0.7 0.0084 16.5 0.7 2.3 3 0 0 3 3 3 1 RNA-binding, Nab2-type zinc finger FYVE PF01363.21 KII66315.1 - 0.014 15.5 1.9 0.019 15.1 0.2 2.0 2 0 0 2 2 2 0 FYVE zinc finger RRM_occluded PF16842.5 KII66315.1 - 0.099 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif PulG PF11773.8 KII66315.1 - 0.11 12.4 0.2 0.73 9.7 0.0 2.2 3 0 0 3 3 3 0 Type II secretory pathway pseudopilin OGG_N PF07934.12 KII66316.1 - 0.05 13.7 0.1 0.065 13.3 0.1 1.1 1 0 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain Integrin_beta PF00362.18 KII66317.1 - 2.7e-06 27.2 1.9 0.032 13.9 0.2 2.6 2 1 1 3 3 3 2 Integrin beta chain VWA domain I-EGF_1 PF18372.1 KII66317.1 - 1.4e-05 25.0 4.9 1.4e-05 25.0 4.9 2.4 3 0 0 3 3 3 1 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 KII66317.1 - 0.0011 19.2 5.3 0.0011 19.2 5.3 2.9 2 1 1 3 3 3 1 EGF-like domain Colipase-like PF15083.6 KII66317.1 - 0.028 14.5 0.4 0.028 14.5 0.4 2.0 2 0 0 2 2 2 0 Colipase-like SNAP PF14938.6 KII66318.1 - 1.6e-10 40.9 0.6 2.3e-10 40.4 0.6 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII66318.1 - 0.011 15.9 4.1 0.011 15.9 4.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KII66318.1 - 0.057 13.1 4.3 0.34 10.6 0.3 3.6 4 0 0 4 4 4 0 TPR repeat TPR_6 PF13174.6 KII66318.1 - 0.26 12.0 2.2 21 6.0 0.6 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII66318.1 - 0.36 11.1 3.4 2.4 8.5 2.4 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII66318.1 - 7.2 6.6 7.7 27 4.8 4.7 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Integrin_beta PF00362.18 KII66321.1 - 0.0012 18.5 0.0 0.0013 18.4 0.0 1.1 1 0 0 1 1 1 1 Integrin beta chain VWA domain SNAP PF14938.6 KII66322.1 - 3.7e-10 39.7 1.4 5e-10 39.3 1.4 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP I-EGF_1 PF18372.1 KII66323.1 - 3.2e-10 39.9 23.2 1.3e-05 25.2 4.5 3.2 3 0 0 3 3 3 2 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 KII66323.1 - 8e-05 22.9 31.8 0.0018 18.6 5.3 4.0 3 1 1 4 4 4 2 EGF-like domain Imm48 PF15574.6 KII66323.1 - 0.0048 16.7 0.0 2.1 8.1 0.0 2.5 2 0 0 2 2 2 2 Immunity protein 48 Integrin_beta PF00362.18 KII66323.1 - 0.015 15.0 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Integrin beta chain VWA domain RuvB_C PF05491.13 KII66323.1 - 0.049 13.5 0.1 3.5 7.6 0.0 2.6 2 0 0 2 2 2 0 RuvB C-terminal winged helix domain DUF2835 PF11197.8 KII66323.1 - 0.11 12.4 0.0 23 4.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2835) XTBD PF11952.8 KII66323.1 - 0.14 11.9 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD tRNA-synt_2 PF00152.20 KII66323.1 - 0.17 10.9 0.2 0.31 10.1 0.2 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) DBP10CT PF08147.12 KII66323.1 - 0.45 10.8 2.6 10 6.5 1.2 2.9 2 1 0 2 2 2 0 DBP10CT (NUC160) domain SNAP PF14938.6 KII66324.1 - 7.8e-07 28.8 2.0 9.2e-07 28.6 2.0 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII66324.1 - 0.0053 17.0 2.3 0.0064 16.8 2.3 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat MapZ_EC1 PF18041.1 KII66326.1 - 0.095 12.9 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 MapZ extracellular domain 1 SNAP PF14938.6 KII66327.1 - 3.9e-11 42.9 2.2 5.3e-11 42.5 2.2 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Y_phosphatase3 PF13350.6 KII66327.1 - 0.084 12.8 1.5 0.13 12.2 1.5 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family SNAP PF14938.6 KII66328.1 - 3.7e-11 43.0 1.4 5.1e-11 42.5 1.4 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SCRG1 PF15224.6 KII66328.1 - 0.036 14.2 0.5 0.079 13.1 0.1 1.8 1 1 0 1 1 1 0 Scrapie-responsive protein 1 NSF PF02071.20 KII66328.1 - 0.37 11.7 3.8 51 5.3 0.3 4.4 4 1 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat PLAC8 PF04749.17 KII66329.1 - 8.8e-15 55.5 14.1 1e-14 55.3 14.1 1.1 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KII66330.1 - 4.2e-18 66.2 15.8 4.8e-18 66.0 15.8 1.0 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KII66331.1 - 7.1e-19 68.7 6.6 8.1e-19 68.5 6.6 1.0 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KII66332.1 - 2.1e-18 67.1 17.2 2.5e-18 66.9 17.2 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4218 PF13960.6 KII66332.1 - 0.019 14.6 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) PLAC8 PF04749.17 KII66333.1 - 8.5e-18 65.2 15.8 9.8e-18 65.0 15.8 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4218 PF13960.6 KII66333.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) PLAC8 PF04749.17 KII66334.1 - 6.7e-15 55.9 10.3 1e-14 55.3 10.3 1.2 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KII66335.1 - 3.9e-09 37.4 9.0 5.1e-09 37.0 9.0 1.2 1 0 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KII66337.1 - 1.6e-07 32.3 1.8 2.4e-07 31.7 1.8 1.3 1 0 0 1 1 1 1 PLAC8 family DUF1170 PF06663.13 KII66337.1 - 0.039 13.7 1.3 0.27 10.9 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1170) DUF4825 PF16107.5 KII66337.1 - 1.6 8.9 5.6 0.61 10.2 0.4 2.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4825) Rep_N PF08724.10 KII66338.1 - 0.0032 17.2 0.0 0.0039 17.0 0.0 1.1 1 0 0 1 1 1 1 Rep protein catalytic domain like PLAC8 PF04749.17 KII66340.1 - 2.9e-16 60.3 18.3 3.4e-16 60.1 18.3 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4218 PF13960.6 KII66340.1 - 0.0095 15.5 0.1 0.016 14.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) PLAC8 PF04749.17 KII66343.1 - 5.3e-17 62.6 14.8 6.2e-17 62.4 14.8 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4218 PF13960.6 KII66343.1 - 0.0019 17.8 0.2 0.0033 17.0 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4218) WD40 PF00400.32 KII66345.1 - 5.1e-12 46.1 4.3 0.0053 17.6 0.2 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII66345.1 - 0.00097 19.4 0.1 0.0035 17.6 0.1 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KII66345.1 - 0.0084 15.5 0.1 0.01 15.2 0.1 1.0 1 0 0 1 1 1 1 WD40-like domain BBS2_Mid PF14783.6 KII66345.1 - 0.026 14.6 0.0 0.042 13.9 0.0 1.5 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region CTXphi_pIII-N1 PF16710.5 KII66345.1 - 0.06 13.5 0.1 0.077 13.1 0.1 1.2 1 0 0 1 1 1 0 N-terminal N1 domain of Vibrio phage CTXphi pIII WD40 PF00400.32 KII66346.1 - 1.3e-14 54.3 21.2 0.01 16.7 0.0 8.1 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII66346.1 - 8.1e-07 29.3 3.9 0.086 13.2 0.0 5.6 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Mcl1_mid PF12341.8 KII66346.1 - 0.0004 19.8 0.2 0.048 13.0 0.1 2.2 2 0 0 2 2 2 2 Minichromosome loss protein, Mcl1, middle region NUP214 PF16755.5 KII66346.1 - 0.0076 15.5 6.7 3.9 6.6 0.7 3.1 2 1 0 3 3 3 3 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Cytochrom_D1 PF02239.16 KII66346.1 - 0.07 11.7 0.1 1.9 6.9 0.1 2.7 1 1 2 3 3 3 0 Cytochrome D1 heme domain VHS PF00790.19 KII66347.1 - 2.6e-07 30.6 0.0 3e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 VHS domain ENTH PF01417.20 KII66347.1 - 0.14 12.2 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 ENTH domain WD40 PF00400.32 KII66348.1 - 2.4e-15 56.6 18.9 0.00013 22.7 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII66348.1 - 1e-09 38.5 0.0 0.015 15.6 0.0 3.7 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KII66348.1 - 0.016 13.5 0.0 0.088 11.1 0.0 2.0 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Rav1p_C PF12234.8 KII66348.1 - 0.071 11.5 0.0 0.1 11.0 0.0 1.1 1 0 0 1 1 1 0 RAVE protein 1 C terminal PD40 PF07676.12 KII66348.1 - 0.096 12.7 0.3 2.6 8.1 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DDE_3 PF13358.6 KII66349.1 - 8.2e-23 80.8 0.0 1.4e-22 80.1 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease Imm-NTF2-2 PF15631.6 KII66349.1 - 0.013 15.7 0.1 0.12 12.6 0.0 2.1 2 0 0 2 2 2 0 NTF2 fold immunity protein PAX PF00292.18 KII66350.1 - 9e-05 22.4 0.1 0.00012 22.0 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_24 PF13412.6 KII66350.1 - 0.003 17.1 0.2 0.36 10.4 0.1 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Sigma70_r4_2 PF08281.12 KII66350.1 - 0.0052 16.4 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 TrmB PF01978.19 KII66350.1 - 0.013 15.4 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB GUCT PF08152.12 KII66350.1 - 0.036 14.3 0.2 0.061 13.6 0.2 1.4 1 1 0 1 1 1 0 GUCT (NUC152) domain HTH_23 PF13384.6 KII66350.1 - 0.043 13.6 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_8 PF02954.19 KII66350.1 - 0.044 13.6 0.1 0.24 11.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family TipE PF16972.5 KII66350.1 - 0.067 12.4 0.3 0.081 12.1 0.3 1.1 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE Sigma70_r4 PF04545.16 KII66350.1 - 0.14 11.7 0.0 0.36 10.4 0.0 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 Homeobox_KN PF05920.11 KII66352.1 - 5e-16 58.3 0.6 1.1e-15 57.3 0.3 1.7 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 KII66352.1 - 8e-07 28.8 0.1 1.9e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 Homeodomain DotA PF11388.8 KII66352.1 - 0.029 14.6 0.3 0.044 14.0 0.3 1.6 1 1 0 1 1 1 0 Phagosome trafficking protein DotA SIR2 PF02146.17 KII66353.1 - 3.4e-34 118.3 0.0 5.4e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DZR PF12773.7 KII66353.1 - 0.023 14.7 0.3 0.26 11.3 0.3 2.2 1 1 1 2 2 2 0 Double zinc ribbon NepR PF18557.1 KII66353.1 - 0.18 11.5 0.8 0.35 10.5 0.8 1.5 1 0 0 1 1 1 0 Anti-sigma factor NepR C1_1 PF00130.22 KII66353.1 - 0.22 11.5 1.4 1.1 9.2 0.5 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-ribbon_3 PF13248.6 KII66353.1 - 0.27 10.7 6.5 4.9 6.7 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain DUF3716 PF12511.8 KII66353.1 - 0.62 10.1 4.5 3.2 7.9 4.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3716) Pro_isomerase PF00160.21 KII66354.1 - 1.1e-45 155.7 0.0 2.5e-45 154.6 0.0 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 KII66354.1 - 4.3e-08 32.8 0.2 4.3e-08 32.8 0.2 2.2 2 0 0 2 2 2 1 Rtf2 RING-finger DnaJ_C PF01556.18 KII66356.1 - 2.1e-19 70.1 0.0 2.6e-19 69.8 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain HpcH_HpaI PF03328.14 KII66358.1 - 6.7e-26 90.8 0.0 9.1e-26 90.4 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 KII66358.1 - 0.016 14.4 0.0 0.13 11.4 0.0 2.1 2 0 0 2 2 2 0 C-C_Bond_Lyase of the TIM-Barrel fold FLYWCH PF04500.16 KII66360.1 - 0.02 15.0 1.5 0.035 14.2 1.5 1.4 1 0 0 1 1 1 0 FLYWCH zinc finger domain DUF1533 PF07550.11 KII66360.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) Zn_ribbon_recom PF13408.6 KII66360.1 - 1.5 9.4 5.4 3.2 8.3 5.4 1.8 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain Thoc2 PF11732.8 KII66361.1 - 0.099 12.7 0.1 0.23 11.5 0.1 1.6 1 0 0 1 1 1 0 Transcription- and export-related complex subunit Serpin PF00079.20 KII66362.1 - 3.1e-19 69.5 2.8 4e-19 69.2 2.8 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII66363.1 - 9.2e-13 48.2 0.2 1.1e-12 48.0 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Pox_A31 PF05771.11 KII66363.1 - 0.099 12.7 0.7 0.19 11.7 0.6 1.6 1 1 1 2 2 2 0 Poxvirus A31 protein Glyco_hydro_38 PF18438.1 KII66363.1 - 0.11 12.5 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal domain 1 Serpin PF00079.20 KII66364.1 - 3.5e-20 72.6 0.2 4e-20 72.4 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF2333 PF10095.9 KII66364.1 - 0.029 13.4 0.0 0.036 13.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) Serpin PF00079.20 KII66365.1 - 9.6e-27 94.2 0.7 1.1e-26 94.0 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.6 KII66366.1 - 5.6e-12 45.7 3.4 6.8e-12 45.4 3.4 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DHR-2 PF06920.13 KII66366.1 - 0.0028 16.4 0.2 0.0058 15.3 0.3 1.4 2 0 0 2 2 2 1 Dock homology region 2 TPR_2 PF07719.17 KII66366.1 - 0.0088 16.1 11.5 0.68 10.2 1.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 KII66366.1 - 0.013 16.1 2.1 3.8 8.4 0.3 4.0 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 KII66366.1 - 0.021 15.1 3.3 0.54 10.6 0.8 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat FRB_dom PF08771.11 KII66366.1 - 0.2 12.1 2.5 0.98 9.9 0.0 2.5 2 2 0 2 2 2 0 FKBP12-rapamycin binding domain TPR_8 PF13181.6 KII66366.1 - 0.55 10.6 11.7 7.6 7.0 0.5 4.7 4 1 0 5 5 5 0 Tetratricopeptide repeat NSF PF02071.20 KII66366.1 - 0.58 11.1 5.6 48 5.4 0.0 4.3 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_7 PF13176.6 KII66366.1 - 0.61 10.3 4.6 14 5.9 0.2 4.2 3 1 2 5 5 5 0 Tetratricopeptide repeat AAA_22 PF13401.6 KII66367.1 - 6.9e-05 23.1 0.0 0.00032 21.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KII66367.1 - 0.00016 22.0 2.6 0.092 13.2 0.0 3.3 3 0 0 3 3 3 2 RNA helicase AAA PF00004.29 KII66367.1 - 0.0044 17.4 0.0 0.013 15.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) EF-hand_14 PF17959.1 KII66367.1 - 0.0085 16.4 0.0 0.041 14.2 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain TsaE PF02367.17 KII66367.1 - 0.0088 16.0 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF3856 PF12968.7 KII66367.1 - 0.041 13.9 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) AAA_16 PF13191.6 KII66367.1 - 0.048 14.1 0.0 0.3 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 KII66367.1 - 0.073 12.2 0.0 0.46 9.6 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 KII66367.1 - 0.082 12.9 0.0 2.5 8.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 KII66367.1 - 0.15 12.0 0.0 0.46 10.4 0.0 1.8 1 1 0 1 1 1 0 NACHT domain TLD PF07534.16 KII66368.1 - 1.3e-30 106.4 2.3 2.5e-30 105.5 1.5 1.8 2 0 0 2 2 2 1 TLD DUF1192 PF06698.11 KII66370.1 - 0.011 15.8 0.1 0.026 14.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) THOC7 PF05615.13 KII66370.1 - 0.017 15.4 6.6 0.099 12.9 0.2 2.6 2 1 0 2 2 2 0 Tho complex subunit 7 Prp19 PF08606.11 KII66370.1 - 0.063 13.3 2.1 5 7.2 0.0 3.2 2 1 1 3 3 3 0 Prp19/Pso4-like Bap31_Bap29_C PF18035.1 KII66370.1 - 0.065 13.3 0.2 0.065 13.3 0.2 2.8 2 0 0 2 2 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4407 PF14362.6 KII66370.1 - 0.12 11.7 4.2 0.18 11.1 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CortBP2 PF09727.9 KII66370.1 - 0.2 11.6 14.5 0.12 12.2 4.9 2.2 1 1 1 2 2 2 0 Cortactin-binding protein-2 HALZ PF02183.18 KII66370.1 - 0.34 11.2 14.8 0.99 9.7 2.9 3.3 3 1 0 3 3 3 0 Homeobox associated leucine zipper Cep57_CLD_2 PF14197.6 KII66370.1 - 0.5 10.5 8.5 5.2 7.2 1.2 2.6 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 NYD-SP28_assoc PF14775.6 KII66370.1 - 0.51 10.5 4.5 0.59 10.3 0.6 2.5 2 0 0 2 2 2 0 Sperm tail C-terminal domain Cep57_MT_bd PF06657.13 KII66370.1 - 0.52 10.8 11.5 1.1 9.8 4.6 2.8 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DivIC PF04977.15 KII66370.1 - 0.8 9.5 6.9 0.41 10.5 0.4 2.8 2 1 0 2 2 2 0 Septum formation initiator DUF4140 PF13600.6 KII66370.1 - 0.89 10.0 3.8 0.33 11.4 0.3 2.0 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Allexi_40kDa PF05549.11 KII66370.1 - 1.2 8.6 7.4 4.4 6.7 0.7 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein Nup54 PF13874.6 KII66370.1 - 1.6 8.9 5.8 1.3 9.1 0.7 2.2 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 ZapB PF06005.12 KII66370.1 - 6.4 7.3 11.9 2.7e+03 -1.1 11.9 3.0 1 1 0 1 1 1 0 Cell division protein ZapB RT_RNaseH_2 PF17919.1 KII66374.1 - 9e-34 115.5 0.0 2.3e-33 114.2 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII66374.1 - 1e-31 109.3 0.0 2.3e-31 108.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII66374.1 - 1.1e-19 70.8 0.1 2.5e-19 69.6 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 KII66374.1 - 9e-19 67.9 0.0 2.5e-18 66.4 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII66374.1 - 2.8e-16 59.4 0.3 9.3e-16 57.7 0.3 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII66374.1 - 8.1e-08 32.4 0.0 2.1e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC PF00098.23 KII66374.1 - 1.1e-05 25.3 11.1 0.018 15.1 5.2 2.7 2 0 0 2 2 2 2 Zinc knuckle rve_3 PF13683.6 KII66374.1 - 5.6e-05 22.8 0.0 0.00014 21.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII66374.1 - 0.015 15.0 0.1 0.037 13.8 0.1 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease gag-asp_proteas PF13975.6 KII66374.1 - 0.017 15.7 0.0 0.043 14.4 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Nepo_coat_N PF03689.15 KII66374.1 - 0.13 12.2 0.1 0.61 10.1 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Asp_protease_2 PF13650.6 KII66374.1 - 0.17 12.5 0.0 0.38 11.4 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_2 PF13696.6 KII66374.1 - 1.9 8.4 12.7 0.49 10.3 5.0 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII66374.1 - 2.5 7.9 7.6 3 7.6 0.8 2.6 2 0 0 2 2 2 0 Zinc knuckle Tmemb_9 PF05434.11 KII66376.1 - 0.0019 18.1 0.0 0.0019 18.1 0.0 2.4 3 0 0 3 3 3 1 TMEM9 IU_nuc_hydro PF01156.19 KII66377.1 - 8.4e-48 163.5 0.0 1e-47 163.2 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Sortilin-Vps10 PF15902.5 KII66378.1 - 5.5e-11 41.9 0.6 1.2e-10 40.8 0.6 1.5 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII66378.1 - 9.1e-05 21.9 4.9 4.4 7.7 0.0 3.7 3 0 0 3 3 3 3 BNR/Asp-box repeat Vps36-NZF-N PF16988.5 KII66378.1 - 0.087 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Serpin PF00079.20 KII66379.1 - 4.7e-42 144.6 2.0 5.4e-42 144.4 2.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ldl_recept_a PF00057.18 KII66382.1 - 2e-10 40.7 25.9 1.7e-06 28.1 7.2 2.6 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII66383.1 - 3.8e-16 59.0 47.2 3.1e-08 33.7 8.5 3.9 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII66384.1 - 1e-09 39.0 0.1 1.3e-09 38.7 0.1 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal RVT_1 PF00078.27 KII66394.1 - 2.5e-11 43.5 0.1 4.7e-11 42.6 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRIMA1 PF16101.5 KII66399.1 - 0.00044 20.3 1.6 0.00056 19.9 1.6 1.2 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 TMEM154 PF15102.6 KII66399.1 - 0.00099 19.0 2.6 0.00099 19.0 2.6 1.4 1 1 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.6 KII66399.1 - 0.0057 16.5 0.2 0.0073 16.1 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) EphA2_TM PF14575.6 KII66399.1 - 0.0081 17.0 1.6 0.077 13.9 2.0 2.0 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Phospholamban PF04272.14 KII66399.1 - 0.01 15.3 0.5 0.022 14.2 0.5 1.6 1 0 0 1 1 1 1 Phospholamban Orf78 PF06024.12 KII66399.1 - 0.046 14.0 0.3 0.071 13.4 0.1 1.6 1 1 0 1 1 1 0 Orf78 (ac78) Orthoreo_P10 PF07204.11 KII66399.1 - 0.064 13.2 0.8 0.3 11.1 1.2 1.8 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 Cadherin_C_2 PF16492.5 KII66399.1 - 0.11 13.3 1.5 0.51 11.1 1.8 1.8 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF2207 PF09972.9 KII66399.1 - 0.12 11.1 0.0 0.13 11.0 0.0 1.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM51 PF15345.6 KII66399.1 - 0.33 10.8 2.1 0.44 10.3 1.6 1.4 1 1 1 2 2 2 0 Transmembrane protein 51 EF-hand_4 PF12763.7 KII66403.1 - 1e-11 44.7 0.1 2.6e-11 43.4 0.0 1.7 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 KII66403.1 - 0.00061 19.2 0.1 0.0016 17.8 0.1 1.8 1 0 0 1 1 1 1 EF hand Homeodomain PF00046.29 KII66404.1 - 2.3e-09 36.9 1.7 4.7e-09 36.0 1.7 1.5 1 0 0 1 1 1 1 Homeodomain Thiolase_N PF00108.23 KII66405.1 - 6.4e-76 255.1 0.2 8.5e-76 254.7 0.2 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KII66405.1 - 2.6e-41 140.1 0.7 2.6e-41 140.1 0.7 1.9 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KII66405.1 - 4.4e-06 26.4 0.9 2.3e-05 24.1 0.5 2.0 2 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KII66405.1 - 0.058 13.2 0.5 17 5.3 0.0 2.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Stevor PF17410.2 KII66409.1 - 0.0088 15.6 0.8 0.023 14.3 0.0 1.9 2 0 0 2 2 2 1 Subtelomeric Variable Open Reading frame DUF2207 PF09972.9 KII66409.1 - 0.017 13.9 0.0 0.027 13.3 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4366 PF14283.6 KII66409.1 - 0.25 11.4 1.2 0.78 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) EGF PF00008.27 KII66411.1 - 0.00028 21.1 3.1 0.00028 21.1 3.1 4.7 3 1 1 4 4 4 1 EGF-like domain EGF_3 PF12947.7 KII66411.1 - 0.012 15.8 5.8 0.012 15.8 5.8 3.7 2 2 2 4 4 4 0 EGF domain CUB PF00431.20 KII66412.1 - 0.023 15.0 0.9 0.023 15.0 0.9 1.8 2 1 0 2 2 2 0 CUB domain SNF2_N PF00176.23 KII66413.1 - 2.5e-22 79.1 0.8 9.5e-20 70.6 0.1 2.1 1 1 1 2 2 2 2 SNF2 family N-terminal domain DEAD PF00270.29 KII66413.1 - 0.0028 17.5 0.0 0.0029 17.4 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KII66413.1 - 0.0028 17.7 0.0 0.0032 17.5 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 KII66413.1 - 0.0076 15.2 0.0 0.008 15.1 0.0 1.0 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 SNF2_N PF00176.23 KII66414.1 - 1.3e-06 27.4 0.3 1.6e-06 27.1 0.3 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HECT PF00632.25 KII66418.1 - 3.1e-64 217.4 0.2 3.4e-64 217.3 0.2 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.25 KII66419.1 - 0.16 11.3 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain NOP5NT PF08156.13 KII66421.1 - 0.021 15.2 0.7 2.4 8.6 0.0 2.4 2 1 0 2 2 2 0 NOP5NT (NUC127) domain RNB PF00773.19 KII66423.1 - 7.5e-84 281.8 0.6 1.1e-83 281.3 0.6 1.2 1 0 0 1 1 1 1 RNB domain Ribosomal_L22e PF01776.17 KII66423.1 - 0.034 14.5 0.4 0.12 12.8 0.4 1.9 1 0 0 1 1 1 0 Ribosomal L22e protein family DUF421 PF04239.12 KII66424.1 - 0.0014 18.4 0.7 0.003 17.3 0.7 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF421) FmiP_Thoc5 PF09766.9 KII66424.1 - 0.016 14.5 2.1 0.019 14.2 2.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 DUF5070 PF16802.5 KII66424.1 - 0.088 12.8 2.0 0.98 9.4 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5070) DUF1664 PF07889.12 KII66424.1 - 0.097 12.7 2.9 4.3 7.4 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DDE_Tnp_IS1595 PF12762.7 KII66425.1 - 1.4e-12 47.9 0.0 3.4e-12 46.6 0.0 1.6 1 1 1 2 2 2 1 ISXO2-like transposase domain HTH_23 PF13384.6 KII66425.1 - 1.1e-05 25.0 0.0 2.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 KII66425.1 - 0.0017 17.7 0.3 0.003 16.9 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_38 PF13936.6 KII66425.1 - 0.0054 16.5 1.6 0.011 15.5 0.2 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 KII66425.1 - 0.014 15.5 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix Sigma70_r4 PF04545.16 KII66425.1 - 0.02 14.4 0.1 0.039 13.5 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 KORA PF16509.5 KII66425.1 - 0.022 15.0 0.0 0.055 13.8 0.0 1.6 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor CENP-B_N PF04218.13 KII66425.1 - 0.12 12.0 0.1 0.23 11.1 0.1 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 KII66425.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain RRS1 PF04939.12 KII66426.1 - 6.6e-32 110.6 3.9 9.8e-32 110.1 3.9 1.2 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DNA_pol_alpha_N PF12254.8 KII66426.1 - 0.029 14.4 0.7 0.029 14.4 0.7 2.0 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal NUDIX PF00293.28 KII66427.1 - 6.4e-16 58.6 0.0 1.4e-15 57.5 0.0 1.5 2 0 0 2 2 2 1 NUDIX domain Toxin_8 PF07365.12 KII66427.1 - 0.07 13.3 0.5 0.14 12.3 0.5 1.4 1 0 0 1 1 1 0 Alpha conotoxin precursor DDE_Tnp_IS1595 PF12762.7 KII66429.1 - 1.9e-13 50.7 0.0 4.3e-13 49.5 0.0 1.5 2 0 0 2 2 2 1 ISXO2-like transposase domain Zn_ribbon_recom PF13408.6 KII66429.1 - 0.015 15.8 2.2 0.05 14.1 1.2 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain FYVE PF01363.21 KII66429.1 - 0.025 14.7 1.5 0.051 13.7 1.5 1.5 1 0 0 1 1 1 0 FYVE zinc finger zinc-ribbons_6 PF07191.12 KII66429.1 - 0.072 13.1 1.4 0.14 12.1 1.4 1.4 1 0 0 1 1 1 0 zinc-ribbons zf_UBZ PF18439.1 KII66429.1 - 0.79 9.4 4.2 7.1 6.3 0.5 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger WD40_like PF17005.5 KII66431.1 - 0.087 12.1 0.1 0.1 11.9 0.1 1.1 1 0 0 1 1 1 0 WD40-like domain Gal-3-0_sulfotr PF06990.11 KII66434.1 - 4.7e-17 62.0 7.0 1.2e-15 57.3 7.0 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase DUF3888 PF13027.6 KII66436.1 - 0.083 13.3 0.5 0.24 11.8 0.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3888) FG-GAP PF01839.23 KII66438.1 - 1.7e-10 40.8 3.9 2.4e-05 24.4 2.9 2.4 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.6 KII66438.1 - 5.4e-07 30.1 8.6 2.4e-06 28.1 1.3 3.1 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Astacin PF01400.24 KII66439.1 - 0.12 12.0 0.4 0.18 11.4 0.2 1.4 1 1 1 2 2 2 0 Astacin (Peptidase family M12A) SNAP PF14938.6 KII66442.1 - 8.1e-07 28.7 8.4 1.3e-05 24.8 8.4 2.2 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP NDUFB11 PF17250.2 KII66442.1 - 0.042 14.5 0.8 0.95 10.1 0.0 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase 11 kDa subunit Peptidase_M1 PF01433.20 KII66443.1 - 2.6e-07 30.4 0.0 2.9e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain TAP_C PF03943.13 KII66447.1 - 0.15 11.7 0.3 6.3 6.5 0.1 2.4 2 1 0 2 2 2 0 TAP C-terminal domain rve PF00665.26 KII66450.1 - 2e-20 73.1 0.0 4.4e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII66450.1 - 3e-15 56.0 0.2 6e-15 55.1 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII66450.1 - 0.0064 16.2 0.4 0.022 14.5 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain RloB PF13707.6 KII66450.1 - 0.065 13.4 0.8 0.13 12.5 0.1 1.9 2 0 0 2 2 2 0 RloB-like protein Rubredoxin_C PF18267.1 KII66452.1 - 7.6e-09 35.4 0.0 1.5e-08 34.4 0.0 1.5 2 0 0 2 2 2 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox_2 PF07992.14 KII66452.1 - 0.089 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SET PF00856.28 KII66453.1 - 2.3e-21 76.9 0.7 2.3e-21 76.9 0.7 4.6 3 1 0 3 3 3 1 SET domain DER1 PF04511.15 KII66454.1 - 3.3e-24 85.9 3.9 3.9e-24 85.6 3.9 1.1 1 0 0 1 1 1 1 Der1-like family Ost4 PF10215.9 KII66455.1 - 0.13 12.1 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 Oligosaccaryltransferase DUF1368 PF07112.11 KII66457.1 - 0.016 14.0 0.2 0.017 13.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1368) PRELI PF04707.14 KII66459.1 - 7.3e-23 81.1 0.1 1.1e-22 80.5 0.1 1.3 1 0 0 1 1 1 1 PRELI-like family HIGH_NTase1_ass PF16581.5 KII66459.1 - 0.065 13.2 0.3 0.097 12.7 0.3 1.3 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region DUF3367 PF11847.8 KII66459.1 - 0.21 9.4 0.0 0.27 9.1 0.0 1.1 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase DUF2873 PF11395.8 KII66461.1 - 2.8 7.9 8.2 4.5 7.2 8.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2873) Acyl-CoA_dh_1 PF00441.24 KII66462.1 - 3.5e-26 92.2 0.1 1.8e-13 51.0 0.1 2.2 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 KII66462.1 - 6e-05 23.3 0.0 0.0093 16.2 0.0 2.2 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KII66462.1 - 0.017 15.3 0.0 0.03 14.5 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Birna_VP5 PF03042.14 KII66464.1 - 0.073 13.1 0.1 0.1 12.6 0.1 1.4 1 1 0 1 1 1 0 Birnavirus VP5 protein WD40 PF00400.32 KII66466.1 - 1.2e-10 41.8 11.5 4.8e-05 24.1 0.3 6.6 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII66466.1 - 0.012 15.9 0.0 0.99 9.7 0.0 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain BCDHK_Adom3 PF10436.9 KII66466.1 - 0.21 11.4 3.0 2.6 7.9 0.3 2.4 2 0 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase WD40 PF00400.32 KII66467.1 - 2e-34 117.0 15.2 3.2e-05 24.6 0.0 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII66467.1 - 8.1e-08 32.5 0.1 0.63 10.4 0.0 5.0 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KII66467.1 - 2.7e-07 30.7 0.0 0.0016 18.3 0.0 2.4 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KII66467.1 - 0.23 10.1 1.3 7.3 5.1 0.1 3.1 2 1 2 4 4 4 0 Nucleoporin Nup120/160 zf-UBR PF02207.20 KII66471.1 - 6.3e-11 42.3 7.3 6.3e-11 42.3 7.3 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Claudin_2 PF13903.6 KII66472.1 - 0.0036 17.1 12.8 0.085 12.6 11.5 2.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction TMEM190 PF15431.6 KII66472.1 - 0.28 11.3 1.8 5.5 7.1 0.1 2.2 2 0 0 2 2 2 0 Transmembrane protein 190 DNA_pol_viral_N PF00242.17 KII66473.1 - 0.086 12.3 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Hat1_N PF10394.9 KII66481.1 - 8.2e-06 26.1 0.0 1.1e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Rft-1 PF04506.13 KII66483.1 - 1.5e-48 165.9 31.0 1.9e-48 165.5 31.0 1.0 1 0 0 1 1 1 1 Rft protein OST-HTH PF12872.7 KII66484.1 - 1e-10 41.3 1.5 2.3e-08 33.7 0.0 2.9 3 0 0 3 3 3 2 OST-HTH/LOTUS domain TUDOR PF00567.24 KII66485.1 - 0.0049 16.9 0.0 0.0087 16.1 0.0 1.4 1 0 0 1 1 1 1 Tudor domain DUF1218 PF06749.12 KII66487.1 - 0.42 11.2 12.2 0.21 12.1 0.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1218) DUF2670 PF10875.8 KII66487.1 - 1.2 9.2 6.7 4.1 7.5 1.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2670) DHHC PF01529.20 KII66487.1 - 3.7 7.7 12.1 0.086 13.0 3.6 2.2 2 1 0 2 2 2 0 DHHC palmitoyltransferase FANCI_S2 PF14676.6 KII66491.1 - 0.0045 17.3 3.7 2.3 8.5 0.4 3.5 2 1 2 4 4 4 2 FANCI solenoid 2 Coat_X PF07552.11 KII66491.1 - 0.026 14.3 0.5 0.072 12.9 0.5 1.7 1 0 0 1 1 1 0 Spore Coat Protein X and V domain RVP PF00077.20 KII66493.1 - 0.0093 16.3 0.0 0.038 14.3 0.0 2.0 2 1 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII66493.1 - 0.016 15.7 0.0 0.1 13.2 0.0 2.3 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease AT_hook PF02178.19 KII66493.1 - 6.5 7.0 8.0 0.58 10.2 1.4 2.4 2 0 0 2 2 2 0 AT hook motif Rep_fac-A_C PF08646.10 KII66495.1 - 2e-19 69.8 3.9 4.6e-17 62.1 1.0 2.8 2 1 1 3 3 3 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KII66495.1 - 9.8e-13 47.9 0.0 2.8e-12 46.4 0.0 1.7 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 KII66495.1 - 0.00023 21.1 0.2 0.0086 16.0 0.0 2.7 2 1 0 3 3 3 1 OB-fold nucleic acid binding domain DUF223 PF02721.14 KII66495.1 - 0.034 14.4 0.0 0.076 13.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF223 Rep_fac-A_C PF08646.10 KII66498.1 - 2.1e-26 92.4 4.2 7.6e-24 84.1 0.9 2.8 3 0 0 3 3 3 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KII66498.1 - 3.3e-22 78.2 0.3 1.1e-21 76.5 0.1 2.0 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 KII66498.1 - 0.00012 22.0 0.0 0.078 13.0 0.0 2.7 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain P21-Arc PF04062.14 KII66501.1 - 0.019 15.0 0.0 0.029 14.4 0.0 1.2 1 1 0 1 1 1 0 ARP2/3 complex ARPC3 (21 kDa) subunit DUF3847 PF12958.7 KII66501.1 - 0.057 13.5 0.0 5 7.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) ACDC PF14733.6 KII66502.1 - 0.9 9.9 5.1 3.9 7.9 0.4 2.7 1 1 2 3 3 3 0 AP2-coincident C-terminal TMEM132D_C PF15706.5 KII66504.1 - 0.077 12.8 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF3149 PF11346.8 KII66504.1 - 0.092 12.4 0.5 0.15 11.7 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) DUF515 PF04415.12 KII66504.1 - 0.14 10.5 0.0 0.18 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Integrin_beta PF00362.18 KII66505.1 - 4.1e-31 108.5 0.8 2.9e-21 76.3 0.2 2.3 2 0 0 2 2 2 2 Integrin beta chain VWA domain DUF4371 PF14291.6 KII66506.1 - 0.012 15.2 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) DUF659 PF04937.15 KII66506.1 - 0.028 14.3 0.0 0.037 13.9 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF 659) DUF3176 PF11374.8 KII66509.1 - 0.032 14.4 0.0 0.041 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3176) Keratin_B2_2 PF13885.6 KII66510.1 - 5e-28 96.8 141.6 0.00055 19.8 17.3 7.6 1 1 6 7 7 7 7 Keratin, high sulfur B2 protein Hexokinase_2 PF03727.16 KII66511.1 - 2.2e-64 217.2 0.0 2.6e-64 216.9 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII66511.1 - 2.8e-23 82.9 0.0 5e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Hexokinase DUF2012 PF09430.10 KII66512.1 - 0.35 11.0 1.5 0.38 10.9 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) RVT_1 PF00078.27 KII66515.1 - 8.2e-08 32.0 0.1 1.2e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII66516.1 - 9.4e-19 67.7 0.7 2.3e-18 66.4 0.2 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII66516.1 - 1.7e-12 47.3 0.4 5.7e-12 45.6 0.1 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Plant_NMP1 PF06694.11 KII66517.1 - 0.19 10.8 0.1 0.28 10.3 0.0 1.3 1 1 0 1 1 1 0 Plant nuclear matrix protein 1 (NMP1) Hexokinase_2 PF03727.16 KII66518.1 - 2.3e-64 217.1 0.0 2.8e-64 216.8 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII66518.1 - 1e-23 84.3 0.0 1.9e-23 83.4 0.0 1.5 1 0 0 1 1 1 1 Hexokinase EVI2A PF05399.11 KII66520.1 - 0.0051 16.4 4.7 0.0061 16.2 4.7 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) AJAP1_PANP_C PF15298.6 KII66520.1 - 1.1 9.5 19.8 8.4 6.6 19.8 1.9 1 1 0 1 1 1 0 AJAP1/PANP C-terminus TMEM154 PF15102.6 KII66520.1 - 3.7 7.4 13.0 0.16 11.9 3.0 2.1 1 1 1 2 2 2 0 TMEM154 protein family RVT_1 PF00078.27 KII66521.1 - 1.6e-23 83.4 0.0 2.5e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Nup96 PF12110.8 KII66521.1 - 0.2 10.8 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Nuclear protein 96 Fimbrial_PilY2 PF14481.6 KII66526.1 - 0.05 13.3 0.0 0.059 13.0 0.0 1.1 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 DDE_Tnp_IS1595 PF12762.7 KII66528.1 - 8.9e-06 25.8 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain WRC PF08879.10 KII66528.1 - 0.0034 17.0 1.6 0.0092 15.7 1.6 1.7 1 0 0 1 1 1 1 WRC Ribosomal_S4e PF00900.20 KII66529.1 - 1.2e-33 114.9 1.4 6.4e-33 112.5 0.4 2.5 3 0 0 3 3 3 1 Ribosomal family S4e 40S_S4_C PF16121.5 KII66529.1 - 2.6e-21 75.0 0.0 7.7e-21 73.5 0.0 1.8 2 0 0 2 2 2 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 KII66529.1 - 8.6e-20 70.6 5.2 4.6e-19 68.2 5.6 2.0 2 0 0 2 2 2 1 RS4NT (NUC023) domain KOW PF00467.29 KII66529.1 - 1.1e-05 25.2 0.6 1.1e-05 25.2 0.6 2.5 2 0 0 2 2 2 1 KOW motif S4 PF01479.25 KII66529.1 - 2.8e-05 23.8 0.1 9.4e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 S4 domain Sipho_tail PF05709.11 KII66529.1 - 0.057 12.8 0.1 0.087 12.2 0.1 1.3 1 0 0 1 1 1 0 Phage tail protein Flu_NP PF00506.18 KII66530.1 - 0.025 13.2 0.1 0.039 12.6 0.1 1.1 1 0 0 1 1 1 0 Influenza virus nucleoprotein RRM_1 PF00076.22 KII66532.1 - 3.5e-13 49.2 0.0 5.9e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 KII66532.1 - 6.5e-05 23.4 1.7 6.5e-05 23.4 1.7 2.4 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Phosphodiest PF01663.22 KII66533.1 - 5.2e-12 46.0 0.1 2.8e-11 43.6 0.1 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase MqsR_toxin PF15723.5 KII66533.1 - 0.02 15.2 0.6 0.7 10.3 0.0 3.2 3 1 1 4 4 4 0 Motility quorum-sensing regulator, toxin of MqsA P16-Arc PF04699.14 KII66533.1 - 0.14 12.6 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) TAF6_C PF07571.13 KII66536.1 - 8.6e-14 51.6 0.0 2.1e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 KII66536.1 - 1.2e-10 41.4 0.1 3e-10 40.1 0.1 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Ribosomal_L17 PF01196.19 KII66537.1 - 0.073 14.0 0.1 0.097 13.6 0.1 1.5 1 1 0 1 1 1 0 Ribosomal protein L17 SRP14 PF02290.15 KII66538.1 - 0.00053 20.3 1.8 0.0031 17.9 1.8 2.0 1 1 0 1 1 1 1 Signal recognition particle 14kD protein SAVED PF18145.1 KII66538.1 - 0.084 12.7 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain RT_RNaseH PF17917.1 KII66540.1 - 8.2e-37 125.7 0.0 1.5e-36 124.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII66540.1 - 2.1e-36 123.9 0.0 5.7e-36 122.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII66540.1 - 3.5e-19 69.1 0.0 1.1e-18 67.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII66540.1 - 3.3e-16 59.1 0.2 6.2e-16 58.3 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII66540.1 - 0.0032 17.2 0.0 0.0085 15.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII66540.1 - 0.0078 16.4 0.0 0.024 14.9 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger DNA_pol_viral_C PF00336.18 KII66540.1 - 0.014 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain CSD2 PF17876.1 KII66540.1 - 0.16 12.2 0.0 0.77 10.0 0.0 2.2 3 0 0 3 3 3 0 Cold shock domain UQ_con PF00179.26 KII66542.1 - 1.4e-22 79.9 0.4 1.6e-22 79.7 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KII66542.1 - 0.025 14.4 0.6 0.043 13.7 0.6 1.4 1 1 0 1 1 1 0 UEV domain OB_NTP_bind PF07717.16 KII66543.1 - 9.6e-09 35.5 0.0 2.2e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold zf-C2H2_4 PF13894.6 KII66543.1 - 1.7 9.7 4.6 1 10.3 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger HA2 PF04408.23 KII66544.1 - 4.6e-09 36.5 0.0 6.2e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KII66545.1 - 1.3e-10 41.6 1.1 3.6e-10 40.2 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 KII66545.1 - 1.8e-06 27.8 1.2 1.7e-05 24.7 0.5 2.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KII66545.1 - 0.00052 20.3 0.3 0.0017 18.6 0.3 1.8 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 KII66545.1 - 0.0077 16.3 0.2 0.15 12.0 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KII66545.1 - 0.012 16.0 0.0 0.031 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KII66545.1 - 0.019 15.0 1.8 0.15 12.1 0.0 3.1 3 1 0 3 3 3 0 AAA domain AAA_23 PF13476.6 KII66545.1 - 0.027 15.0 2.0 0.034 14.6 0.3 2.0 1 1 1 2 2 2 0 AAA domain Rad17 PF03215.15 KII66545.1 - 0.029 14.3 0.7 0.09 12.7 0.7 1.8 1 1 0 1 1 1 0 Rad17 P-loop domain T2SSE PF00437.20 KII66545.1 - 0.054 12.6 0.0 0.085 11.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 KII66545.1 - 0.055 13.2 0.0 0.096 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4796 PF16044.5 KII66546.1 - 0.08 12.5 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4796) DUF2070 PF09843.9 KII66548.1 - 3 6.0 15.4 3.4 5.8 15.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Josephin PF02099.17 KII66549.1 - 3.2e-17 63.1 0.3 1.2e-14 54.7 0.3 2.3 1 1 0 1 1 1 1 Josephin DDE_3 PF13358.6 KII66550.1 - 3.1e-06 27.0 0.0 4.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII66551.1 - 2.2e-05 24.0 0.0 5.4e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII66551.1 - 6.1e-05 23.2 0.5 0.0004 20.6 0.1 2.1 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.6 KII66551.1 - 0.00016 22.2 0.8 0.00026 21.5 0.2 1.7 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.18 KII66551.1 - 0.011 15.7 0.1 0.015 15.2 0.1 1.2 1 0 0 1 1 1 0 'Paired box' domain HTH_Tnp_ISL3 PF13542.6 KII66551.1 - 0.015 14.7 0.7 4.2 6.9 0.0 2.9 2 1 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 KII66551.1 - 0.029 14.2 0.1 0.35 10.7 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain V_ATPase_I PF01496.19 KII66551.1 - 0.044 11.7 0.0 0.047 11.6 0.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ribosomal_L27A PF00828.19 KII66552.1 - 2e-23 83.4 0.1 2.7e-23 83.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A SMC_N PF02463.19 KII66553.1 - 2.2e-08 33.8 0.1 2.7e-08 33.5 0.1 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 KII66553.1 - 6e-07 29.6 0.1 1.2e-06 28.6 0.1 1.5 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 KII66553.1 - 3.4e-05 23.7 0.1 5e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KII66553.1 - 5.4e-05 23.2 0.1 9.4e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Plant_all_beta PF10532.9 KII66553.1 - 0.00028 21.1 0.1 0.96 9.7 0.0 2.3 2 0 0 2 2 2 2 Plant specific N-all beta domain HsbA PF12296.8 KII66554.1 - 0.016 15.6 0.1 0.03 14.7 0.0 1.6 2 0 0 2 2 2 0 Hydrophobic surface binding protein A Baculo_PEP_C PF04513.12 KII66554.1 - 0.018 15.1 0.7 0.05 13.7 0.2 1.7 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LytTR PF04397.15 KII66554.1 - 0.024 14.9 0.1 0.27 11.5 0.1 2.1 1 1 0 1 1 1 0 LytTr DNA-binding domain Orthopox_F8 PF05886.11 KII66554.1 - 0.034 14.3 0.0 0.054 13.6 0.0 1.4 1 1 0 1 1 1 0 Orthopoxvirus F8 protein FlxA PF14282.6 KII66554.1 - 0.11 12.5 0.7 0.19 11.7 0.7 1.4 1 0 0 1 1 1 0 FlxA-like protein Toprim PF01751.22 KII66554.1 - 0.14 12.4 0.0 0.2 11.9 0.0 1.3 1 1 0 1 1 1 0 Toprim domain PKcGMP_CC PF16808.5 KII66555.1 - 0.043 13.7 6.7 0.19 11.6 0.1 4.4 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase NERD PF08378.11 KII66556.1 - 0.0023 18.4 0.4 0.0048 17.3 0.1 1.6 1 1 1 2 2 2 1 Nuclease-related domain YabA PF06156.13 KII66556.1 - 0.0042 17.7 11.1 0.03 14.9 4.7 2.1 1 1 1 2 2 2 2 Initiation control protein YabA V-ATPase_C PF03223.15 KII66556.1 - 0.0048 16.4 0.0 0.0078 15.7 0.0 1.4 1 1 0 1 1 1 1 V-ATPase subunit C ZapB PF06005.12 KII66556.1 - 0.012 16.0 11.9 0.013 15.9 1.3 2.2 1 1 1 2 2 2 0 Cell division protein ZapB Laminin_II PF06009.12 KII66556.1 - 0.083 12.9 10.2 0.045 13.8 5.9 2.0 1 1 1 2 2 2 0 Laminin Domain II RasGEF_N_2 PF14663.6 KII66556.1 - 0.097 13.1 4.3 2.3 8.7 3.5 2.4 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Apt1 PF10351.9 KII66556.1 - 0.11 11.4 7.0 0.076 11.9 5.5 1.3 1 1 0 1 1 1 0 Golgi-body localisation protein domain FlgN PF05130.12 KII66556.1 - 0.15 12.6 10.5 2.1 8.8 7.1 2.1 1 1 1 2 2 2 0 FlgN protein NPV_P10 PF05531.12 KII66556.1 - 0.21 12.1 11.0 18 5.9 5.7 3.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 KII66556.1 - 0.24 11.7 7.2 0.76 10.1 0.5 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Filament PF00038.21 KII66556.1 - 0.25 10.9 12.1 1.4 8.5 1.7 2.7 1 1 1 2 2 2 0 Intermediate filament protein Sec34 PF04136.15 KII66556.1 - 0.26 11.2 10.8 1.3 8.9 10.5 1.9 1 1 1 2 2 2 0 Sec34-like family DUF1664 PF07889.12 KII66556.1 - 0.32 11.0 9.6 0.2 11.7 5.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DivIC PF04977.15 KII66556.1 - 0.33 10.7 11.7 0.82 9.5 1.6 3.1 1 1 3 4 4 4 0 Septum formation initiator Nup54 PF13874.6 KII66556.1 - 0.46 10.6 8.0 0.16 12.1 4.1 1.9 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 RPW8 PF05659.11 KII66556.1 - 0.67 9.6 8.4 2.9 7.6 0.3 3.0 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ABC_tran_CTD PF16326.5 KII66556.1 - 0.71 10.2 6.4 3.1 8.1 0.4 3.1 2 1 1 3 3 3 0 ABC transporter C-terminal domain Med11 PF10280.9 KII66556.1 - 0.87 10.0 10.3 1.3 9.4 10.3 1.3 1 1 0 1 1 1 0 Mediator complex protein Fib_alpha PF08702.10 KII66556.1 - 0.9 9.7 14.8 0.52 10.5 10.0 2.0 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family HemX PF04375.14 KII66556.1 - 1.2 8.3 13.2 1.5 8.1 1.1 2.2 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase AI-2E_transport PF01594.16 KII66556.1 - 1.6 7.8 3.3 1.8 7.6 2.9 1.4 1 1 0 1 1 1 0 AI-2E family transporter DUF2203 PF09969.9 KII66556.1 - 2 9.2 5.1 2.1 9.1 2.2 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF4200 PF13863.6 KII66556.1 - 2.5 8.5 11.1 3.4 8.1 5.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) PRKG1_interact PF15898.5 KII66556.1 - 2.5 9.0 11.8 1.3 10.0 5.4 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Sec2p PF06428.11 KII66556.1 - 4.3 7.4 12.2 9.4 6.3 1.8 3.2 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p DUF3450 PF11932.8 KII66556.1 - 4.7 6.5 13.9 1.9 7.8 9.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) PCRF PF03462.18 KII66556.1 - 6.8 6.5 8.4 3 7.7 4.8 1.8 1 1 1 2 2 2 0 PCRF domain DDE_Tnp_IS1595 PF12762.7 KII66557.1 - 2.5e-18 66.5 0.0 3.7e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain RT_RNaseH PF17917.1 KII66559.1 - 1.7e-33 115.0 0.0 3.8e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII66559.1 - 1.2e-31 108.7 0.0 2.3e-31 107.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII66559.1 - 1.1e-20 74.0 0.0 3.7e-20 72.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII66559.1 - 6.3e-15 55.0 0.0 1.3e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_Tnp_IS1595 PF12762.7 KII66561.1 - 0.038 14.0 0.0 0.054 13.5 0.0 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain SAVED PF18145.1 KII66563.1 - 0.03 14.1 0.1 0.038 13.8 0.1 1.1 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain DUF386 PF04074.12 KII66564.1 - 0.042 13.7 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 YhcH/YjgK/YiaL DDE_3 PF13358.6 KII66566.1 - 3.8e-10 39.7 0.2 4.3e-10 39.5 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease SNAP PF14938.6 KII66568.1 - 2.6e-08 33.6 1.6 2.6e-08 33.6 1.6 1.9 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP LETM1 PF07766.13 KII66568.1 - 0.025 13.9 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 LETM1-like protein SplA PF11132.8 KII66568.1 - 0.18 11.6 3.3 1.6 8.5 0.5 2.4 2 0 0 2 2 2 0 Transcriptional regulator protein (SplA) CysG_dimeriser PF10414.9 KII66569.1 - 0.13 12.0 3.3 0.28 10.9 3.3 1.5 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region SNAP PF14938.6 KII66571.1 - 1.5e-10 41.0 4.9 1.9e-10 40.7 4.9 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP LemA PF04011.12 KII66571.1 - 0.016 15.0 0.8 0.031 14.1 0.8 1.4 1 0 0 1 1 1 0 LemA family SPOB_a PF14689.6 KII66571.1 - 0.023 14.4 0.4 1.4 8.6 0.1 2.7 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_MalT PF17874.1 KII66571.1 - 0.046 13.1 0.0 6.6 6.0 0.0 2.1 1 1 1 2 2 2 0 MalT-like TPR region Enkurin PF13864.6 KII66571.1 - 0.59 10.6 3.1 1.5 9.3 2.5 2.0 2 1 0 2 2 2 0 Calmodulin-binding RVT_1 PF00078.27 KII66577.1 - 2.2e-06 27.4 0.3 0.00012 21.6 0.0 2.6 1 1 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) R-HINP1I PF11463.8 KII66577.1 - 0.027 13.9 1.8 0.048 13.1 0.7 1.9 1 1 1 2 2 2 0 R.HinP1I restriction endonuclease TcdA_TcdB_pore PF12920.7 KII66580.1 - 0.088 11.1 0.0 0.092 11.0 0.0 1.0 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain rve PF00665.26 KII66581.1 - 2.3e-08 34.3 0.0 3.9e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII66581.1 - 0.058 13.2 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH_2 PF17919.1 KII66582.1 - 5.5e-05 23.1 0.1 9.9e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII66582.1 - 0.028 13.9 0.1 0.048 13.2 0.1 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII66583.1 - 0.0013 19.2 0.0 0.011 16.3 0.0 2.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease ScdA_N PF04405.14 KII66583.1 - 0.087 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown function (DUF542) Asp_protease_2 PF13650.6 KII66583.1 - 0.16 12.6 0.0 0.48 11.1 0.0 1.8 2 1 0 2 2 2 0 Aspartyl protease INCA1 PF15142.6 KII66587.1 - 0.051 13.6 0.1 0.056 13.5 0.1 1.2 1 0 0 1 1 1 0 INCA1 Collectrin PF16959.5 KII66589.1 - 0.0027 17.5 0.1 0.0042 16.9 0.1 1.4 1 0 0 1 1 1 1 Renal amino acid transporter SNARE PF05739.19 KII66589.1 - 0.033 14.2 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 SNARE domain DUF1180 PF06679.12 KII66589.1 - 2.5 8.5 4.9 25 5.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) HTH_ABP1_N PF18107.1 KII66591.1 - 0.0065 16.2 0.1 0.01 15.5 0.1 1.3 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain HTH_33 PF13592.6 KII66591.1 - 0.0093 15.6 0.0 0.19 11.4 0.0 2.5 2 0 0 2 2 2 1 Winged helix-turn helix DDE_3 PF13358.6 KII66591.1 - 0.1 12.4 0.0 5.3 6.8 0.0 2.2 1 1 1 2 2 2 0 DDE superfamily endonuclease Gal-3-0_sulfotr PF06990.11 KII66592.1 - 0.024 13.5 0.4 0.024 13.5 0.4 1.1 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase GATA PF00320.27 KII66593.1 - 0.0001 21.8 4.6 0.00034 20.2 4.6 2.0 1 0 0 1 1 1 1 GATA zinc finger zf_UBZ PF18439.1 KII66593.1 - 0.097 12.3 1.2 2.6 7.7 0.1 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 KII66593.1 - 0.15 12.3 1.5 0.85 10.0 1.1 2.6 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding C1_1 PF00130.22 KII66593.1 - 1 9.3 6.5 0.59 10.1 1.7 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 KII66593.1 - 4.1 7.5 10.7 5.8 7.0 1.8 3.6 3 1 1 4 4 4 0 Double zinc ribbon Tnp_zf-ribbon_2 PF13842.6 KII66593.1 - 4.3 8.2 14.4 2.2 9.1 4.0 3.7 2 2 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Nudix_N_2 PF14803.6 KII66593.1 - 8.7 6.4 7.9 53 3.9 0.2 3.8 4 0 0 4 4 4 0 Nudix N-terminal Thioredoxin PF00085.20 KII66594.1 - 0.0041 17.1 0.0 0.0046 16.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 KII66594.1 - 0.1 12.6 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE HTH_Tnp_Tc5 PF03221.16 KII66595.1 - 2.4e-13 49.9 0.1 4.1e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain MLVIN_C PF18697.1 KII66597.1 - 0.0082 16.2 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Atypical_Card PF18461.1 KII66597.1 - 0.063 13.5 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Atypical caspase recruitment domain RVP PF00077.20 KII66598.1 - 0.00019 21.7 0.0 0.00038 20.7 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII66598.1 - 0.0021 18.6 0.0 0.004 17.7 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-C2H2_10 PF16588.5 KII66598.1 - 0.02 14.6 1.4 0.044 13.5 1.4 1.6 1 0 0 1 1 1 0 C2H2 zinc-finger RVP_2 PF08284.11 KII66598.1 - 0.022 14.5 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Peptidase_A2E PF12382.8 KII66598.1 - 0.062 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Retrotransposon peptidase DUF4702 PF15774.5 KII66598.1 - 0.074 12.0 0.1 0.13 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4702) zf-CCHC_2 PF13696.6 KII66598.1 - 0.15 11.9 1.1 0.38 10.6 1.1 1.7 1 0 0 1 1 1 0 Zinc knuckle PHD PF00628.29 KII66598.1 - 0.44 10.5 5.9 0.95 9.4 5.9 1.5 1 0 0 1 1 1 0 PHD-finger zf-CCHC_4 PF14392.6 KII66598.1 - 5.4 6.8 6.0 2.2 8.1 2.2 2.2 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 KII66598.1 - 5.4 7.3 7.5 2.1 8.5 0.3 2.5 2 0 0 2 2 2 0 Zinc knuckle DUF2207 PF09972.9 KII66599.1 - 0.1 11.3 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) KAP PF05804.12 KII66601.1 - 0.012 13.7 0.1 0.014 13.6 0.1 1.0 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) GIIM PF08388.11 KII66601.1 - 0.013 15.5 0.3 0.02 14.9 0.1 1.4 1 1 0 1 1 1 0 Group II intron, maturase-specific domain DUF4064 PF13273.6 KII66603.1 - 0.12 12.7 6.3 0.054 13.8 2.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) SNF2_N PF00176.23 KII66605.1 - 6.5e-63 212.6 3.7 9.6e-61 205.4 0.0 2.6 3 0 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 KII66605.1 - 3.5e-10 40.2 0.2 1.9e-09 37.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 KII66605.1 - 1.7e-07 31.0 5.4 1.7e-07 31.0 5.4 3.7 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII66605.1 - 1.2e-06 28.7 6.4 1.2e-06 28.7 6.4 4.5 4 0 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 KII66605.1 - 2.2e-06 27.5 5.2 2.2e-06 27.5 5.2 4.0 5 0 0 5 5 5 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KII66605.1 - 2.2e-05 24.2 6.5 2.2e-05 24.2 6.5 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KII66605.1 - 3.2e-05 23.9 4.5 3.2e-05 23.9 4.5 3.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KII66605.1 - 3.8e-05 23.5 5.8 3.8e-05 23.5 5.8 3.5 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KII66605.1 - 0.0035 17.5 8.3 0.0035 17.5 8.3 3.1 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KII66605.1 - 0.0089 15.9 6.1 0.0089 15.9 6.1 4.9 4 1 1 5 5 5 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 KII66605.1 - 0.065 13.1 7.3 0.11 12.4 1.4 3.5 3 0 0 3 3 3 0 zf-RING of BARD1-type protein DUF3667 PF12412.8 KII66605.1 - 0.11 12.0 0.1 0.28 10.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3667) zf-UDP PF14569.6 KII66605.1 - 0.93 9.7 8.7 1.4 9.1 1.3 3.4 3 0 0 3 3 3 0 Zinc-binding RING-finger Proteasome PF00227.26 KII66606.1 - 1.1e-53 181.6 0.0 1.7e-53 181.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KII66606.1 - 2.8e-10 39.7 0.1 5e-10 38.9 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PHD_Oberon PF07227.11 KII66607.1 - 0.0039 17.1 2.5 0.0039 17.1 2.5 2.3 2 0 0 2 2 2 1 PHD - plant homeodomain finger protein ELL PF10390.9 KII66607.1 - 0.018 14.6 0.9 0.04 13.4 0.9 1.5 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL DUF5461 PF17545.2 KII66607.1 - 0.13 12.5 1.2 0.34 11.2 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5461) Mg_trans_NIPA PF05653.14 KII66608.1 - 1.2e-15 57.4 12.2 3.3e-14 52.7 5.6 2.4 1 1 1 2 2 2 2 Magnesium transporter NIPA Rad21_Rec8 PF04824.16 KII66608.1 - 0.038 13.3 0.1 0.13 11.6 0.1 1.8 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein DDE_3 PF13358.6 KII66611.1 - 2.3e-15 56.6 0.0 3.4e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease NDUF_B8 PF05821.11 KII66613.1 - 0.027 14.3 0.0 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) zf-RING_2 PF13639.6 KII66615.1 - 6.1e-06 26.5 8.9 2.4e-05 24.6 8.9 2.2 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 KII66615.1 - 0.001 19.1 2.1 0.0029 17.6 2.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 KII66615.1 - 0.0012 19.0 5.5 0.0055 16.9 5.5 2.2 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 KII66615.1 - 0.0016 18.7 7.1 0.006 16.9 7.1 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain RINGv PF12906.7 KII66615.1 - 0.048 13.8 7.6 0.18 12.0 7.6 2.1 1 0 0 1 1 1 0 RING-variant domain C1_1 PF00130.22 KII66615.1 - 0.2 11.5 5.9 0.68 9.9 5.9 2.0 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.25 KII66615.1 - 0.24 11.3 15.1 0.018 14.9 8.7 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 KII66615.1 - 0.36 11.2 7.3 1.7 9.0 7.3 2.3 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.5 KII66615.1 - 0.41 10.8 5.0 0.23 11.6 1.7 2.4 2 0 0 2 2 2 0 KIAA1045 RING finger ER PF01133.17 KII66615.1 - 1 9.4 9.0 4.8 7.3 0.3 4.4 3 0 0 3 3 3 0 Enhancer of rudimentary Zn_ribbon_17 PF17120.5 KII66615.1 - 2.2 7.9 6.5 5.8 6.6 6.5 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 KII66615.1 - 6 6.8 6.8 61 3.6 6.8 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DDE_Tnp_IS1595 PF12762.7 KII66617.1 - 4e-06 26.9 0.1 5.3e-06 26.5 0.1 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain Arm-DNA-bind_2 PF12167.8 KII66617.1 - 0.046 13.6 0.0 0.07 13.1 0.0 1.2 1 0 0 1 1 1 0 Arm DNA-binding domain Patatin PF01734.22 KII66618.1 - 2.7e-11 44.1 0.8 1.3e-10 41.8 0.8 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase Med21 PF11221.8 KII66623.1 - 0.032 14.5 0.8 0.053 13.8 0.8 1.3 1 0 0 1 1 1 0 Subunit 21 of Mediator complex HeLo PF14479.6 KII66623.1 - 0.18 11.6 0.9 0.26 11.1 0.8 1.4 1 1 0 1 1 1 0 Prion-inhibition and propagation GCIP PF13324.6 KII66623.1 - 0.27 10.8 1.6 0.64 9.6 1.3 1.6 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting SF-assemblin PF06705.11 KII66624.1 - 0.034 13.5 0.1 0.09 12.1 0.1 1.7 1 1 0 1 1 1 0 SF-assemblin/beta giardin HTH_23 PF13384.6 KII66627.1 - 4.5e-07 29.5 0.2 0.00019 21.1 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.6 KII66627.1 - 5.5e-06 25.8 0.9 0.00024 20.6 0.1 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_33 PF13592.6 KII66627.1 - 7.5e-06 25.5 0.1 1.4e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 KII66627.1 - 2.9e-05 24.6 0.0 5.8e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_1_2 PF13022.6 KII66627.1 - 4.8e-05 23.5 0.5 0.003 17.7 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_Tnp_Tc3_2 PF01498.18 KII66627.1 - 6.4e-05 23.1 0.3 0.0002 21.6 0.1 1.9 2 0 0 2 2 2 1 Transposase HTH_29 PF13551.6 KII66627.1 - 0.00016 21.6 0.1 0.0013 18.8 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 KII66627.1 - 0.0004 19.7 0.1 0.041 13.3 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 B5 PF03484.15 KII66627.1 - 0.00042 20.6 0.1 0.012 15.9 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetase B5 domain HTH_28 PF13518.6 KII66627.1 - 0.0008 19.5 0.0 0.089 12.9 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII66627.1 - 0.0011 18.8 0.0 0.0015 18.4 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain TrmB PF01978.19 KII66627.1 - 0.002 18.0 0.0 0.013 15.4 0.0 2.1 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB CENP-B_N PF04218.13 KII66627.1 - 0.0026 17.4 0.1 0.025 14.2 0.0 2.2 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain MarR_2 PF12802.7 KII66627.1 - 0.0031 17.3 0.0 0.0076 16.1 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_38 PF13936.6 KII66627.1 - 0.0032 17.2 0.1 0.013 15.3 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain TnsD PF15978.5 KII66627.1 - 0.011 14.8 1.1 2.3 7.1 0.1 2.0 1 1 1 2 2 2 0 Tn7-like transposition protein D MarR PF01047.22 KII66627.1 - 0.015 15.2 0.1 0.91 9.5 0.0 2.6 3 0 0 3 3 3 0 MarR family HTH_19 PF12844.7 KII66627.1 - 0.023 14.7 0.3 21 5.2 0.0 3.0 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_40 PF14493.6 KII66627.1 - 0.023 15.1 0.8 0.036 14.5 0.6 1.4 1 1 0 1 1 1 0 Helix-turn-helix domain Fe_dep_repress PF01325.19 KII66627.1 - 0.024 14.8 0.0 0.087 13.0 0.0 1.9 3 0 0 3 3 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_3 PF01381.22 KII66627.1 - 0.031 14.3 0.5 0.5 10.5 0.1 2.7 2 1 0 3 3 3 0 Helix-turn-helix HTH_11 PF08279.12 KII66627.1 - 0.037 14.0 0.5 3 7.9 0.1 2.3 2 0 0 2 2 2 0 HTH domain Phage_CI_repr PF07022.13 KII66627.1 - 0.045 13.8 0.0 0.06 13.4 0.0 1.4 1 1 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain HTH_50 PF18024.1 KII66627.1 - 0.049 13.3 0.1 0.13 11.9 0.0 1.8 2 0 0 2 2 1 0 Helix-turn-helix domain YdaS_antitoxin PF15943.5 KII66627.1 - 0.049 13.5 0.0 11 6.0 0.0 2.4 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT MULE PF10551.9 KII66631.1 - 0.0084 16.5 0.9 0.39 11.2 0.0 2.8 2 1 1 3 3 3 2 MULE transposase domain DDE_Tnp_IS1595 PF12762.7 KII66633.1 - 0.025 14.6 0.0 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 ISXO2-like transposase domain DALR_1 PF05746.15 KII66633.1 - 0.026 14.7 0.2 0.044 14.0 0.2 1.3 1 0 0 1 1 1 0 DALR anticodon binding domain MurB_C PF02873.16 KII66633.1 - 0.048 13.7 0.0 0.47 10.5 0.0 2.2 2 0 0 2 2 2 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain RT_RNaseH PF17917.1 KII66634.1 - 7.2e-14 52.0 0.0 1.5e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII66634.1 - 7.1e-12 45.2 1.1 1.1e-11 44.6 0.2 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII66635.1 - 1.8e-08 34.6 0.0 3.2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII66635.1 - 0.064 13.5 0.1 0.082 13.1 0.1 1.3 1 0 0 1 1 1 0 DDE domain BRCT_assoc PF12820.7 KII66638.1 - 0.089 12.6 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT Kelch_6 PF13964.6 KII66641.1 - 1.1e-12 47.7 10.2 0.0028 17.9 0.0 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 KII66641.1 - 9e-08 32.2 5.4 0.0047 17.2 0.1 4.5 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KII66641.1 - 1.6e-06 28.0 7.4 0.045 13.8 0.1 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII66641.1 - 0.01 15.8 6.4 25 5.0 0.0 4.8 4 1 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 KII66641.1 - 0.13 11.9 14.9 2.5 7.8 0.2 5.7 7 1 0 7 7 7 0 Kelch motif Kelch_5 PF13854.6 KII66641.1 - 0.13 12.3 4.1 0.24 11.4 0.1 3.2 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 KII66642.1 - 3.4e-07 30.3 5.2 0.00013 22.1 0.1 4.5 3 2 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 KII66642.1 - 1.9 8.6 5.4 0.89 9.6 1.7 2.5 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 KII66643.1 - 0.012 15.9 0.2 0.045 14.0 0.0 2.1 2 1 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 KII66644.1 - 0.0012 19.1 15.5 5 7.6 0.6 5.8 4 3 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 KII66644.1 - 0.063 13.3 4.9 8.7 6.5 0.1 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 KII66644.1 - 1.7 8.3 10.6 2.4 7.8 0.2 4.1 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 KII66647.1 - 3.1e-09 36.8 6.2 0.65 10.4 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII66647.1 - 5.4e-05 23.1 3.6 0.35 10.9 0.0 4.7 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII66647.1 - 0.001 18.9 5.6 0.27 11.3 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 KII66647.1 - 0.0014 18.5 4.5 0.096 12.7 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 KII66647.1 - 0.5 10.0 9.1 1 9.0 0.1 4.7 5 1 0 5 5 5 0 Kelch motif Asp_protease_2 PF13650.6 KII66648.1 - 0.001 19.6 0.0 0.0027 18.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII66648.1 - 0.0012 18.8 2.1 0.0012 18.8 2.1 2.4 4 0 0 4 4 4 1 Zinc knuckle gag-asp_proteas PF13975.6 KII66648.1 - 0.0014 19.2 0.0 0.003 18.1 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Serpin PF00079.20 KII66649.1 - 4.6e-49 167.7 5.0 5.3e-49 167.5 5.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF468 PF04318.12 KII66649.1 - 0.049 14.4 0.1 0.13 13.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF468) Serpin PF00079.20 KII66650.1 - 1.8e-22 80.2 1.2 2.3e-22 79.8 1.2 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) FLYWCH PF04500.16 KII66651.1 - 9.7e-10 38.4 1.0 1.7e-09 37.7 1.0 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII66652.1 - 0.00016 22.0 0.0 0.00026 21.4 0.0 1.4 1 0 0 1 1 1 1 MULE transposase domain Sortilin_C PF15901.5 KII66653.1 - 2.4e-10 41.0 1.1 3.2e-10 40.6 1.1 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII66653.1 - 8e-05 21.6 0.2 0.00011 21.1 0.2 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII66654.1 - 0.00026 21.1 34.0 0.00077 19.6 20.6 3.5 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A DUF2436 PF10365.9 KII66654.1 - 0.11 12.3 0.2 0.2 11.4 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF2436) OmpW PF03922.14 KII66655.1 - 0.016 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 OmpW family Lamp PF01299.17 KII66658.1 - 0.039 13.8 0.9 0.069 13.0 0.9 1.5 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) SurA_N_2 PF13623.6 KII66660.1 - 0.082 12.8 0.1 0.12 12.2 0.1 1.4 1 1 0 1 1 1 0 SurA N-terminal domain DUF4371 PF14291.6 KII66661.1 - 0.0091 15.7 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Kelch_6 PF13964.6 KII66665.1 - 2.6e-22 78.3 14.8 0.00022 21.4 0.2 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 KII66665.1 - 2.6e-18 65.8 14.9 7.7e-05 22.9 0.0 5.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII66665.1 - 5.2e-18 64.3 14.7 5e-05 22.8 0.0 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KII66665.1 - 1.9e-14 53.3 18.6 0.0007 19.6 0.5 5.9 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII66665.1 - 1.5e-08 34.4 12.2 0.13 12.3 0.4 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KII66665.1 - 8.7e-08 31.9 9.9 0.29 11.2 0.1 5.3 5 0 0 5 5 5 3 Kelch motif TFIIA_gamma_C PF02751.14 KII66665.1 - 0.33 11.1 4.0 0.91 9.7 0.0 3.0 3 0 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit PseudoU_synth_1 PF01416.20 KII66670.1 - 5.9e-25 87.8 0.0 1.3e-23 83.5 0.0 2.2 2 0 0 2 2 2 1 tRNA pseudouridine synthase TLD PF07534.16 KII66672.1 - 9.6e-12 45.3 0.0 2.1e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 TLD DUF502 PF04367.13 KII66673.1 - 0.086 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF502) DDE_Tnp_IS1595 PF12762.7 KII66674.1 - 5.5e-08 32.9 0.5 1.3e-07 31.7 0.4 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain CYSTM PF12734.7 KII66674.1 - 0.055 13.8 0.1 0.17 12.2 0.0 1.9 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance E1_DerP2_DerF2 PF02221.15 KII66676.1 - 0.017 15.6 0.1 0.047 14.1 0.1 1.6 1 1 1 2 2 2 0 ML domain E1_DerP2_DerF2 PF02221.15 KII66677.1 - 0.00017 22.0 0.0 0.00022 21.7 0.0 1.1 1 0 0 1 1 1 1 ML domain E1_DerP2_DerF2 PF02221.15 KII66679.1 - 4.9e-06 27.0 0.0 5.9e-06 26.7 0.0 1.0 1 0 0 1 1 1 1 ML domain VWA_2 PF13519.6 KII66683.1 - 6.9e-08 33.1 0.0 9.9e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Cas_GSU0054 PF09609.10 KII66683.1 - 0.053 12.2 0.0 0.064 12.0 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein, GSU0054 family (Cas_GSU0054) UIM PF02809.20 KII66684.1 - 4.9e-08 32.4 4.6 0.0016 18.2 0.3 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif E1_DerP2_DerF2 PF02221.15 KII66688.1 - 9e-05 22.9 0.1 0.00011 22.6 0.1 1.1 1 0 0 1 1 1 1 ML domain Choline_sulf_C PF12411.8 KII66695.1 - 0.051 13.4 0.1 0.093 12.6 0.1 1.4 1 0 0 1 1 1 0 Choline sulfatase enzyme C terminal CENP-B_N PF04218.13 KII66696.1 - 0.068 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain BAR PF03114.18 KII66699.1 - 1.3e-13 51.2 0.1 2.3e-13 50.3 0.1 1.4 1 1 0 1 1 1 1 BAR domain LRR_4 PF12799.7 KII66700.1 - 2.3e-38 129.5 58.4 2.4e-07 31.0 0.7 5.6 2 1 7 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KII66700.1 - 5.4e-19 67.7 26.6 1.4e-05 24.7 6.7 5.3 1 1 3 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 KII66700.1 - 2.8e-12 46.5 15.1 3.6e-06 26.6 1.8 3.0 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 KII66700.1 - 0.0031 17.8 27.0 11 7.0 0.5 8.4 7 2 1 8 8 8 2 Leucine Rich Repeat FNIP PF05725.12 KII66700.1 - 0.1 12.8 9.9 2.5 8.4 0.3 4.3 3 1 0 3 3 3 0 FNIP Repeat Sigma70_r4 PF04545.16 KII66700.1 - 0.13 11.8 0.2 11 5.6 0.0 3.1 3 0 0 3 3 3 0 Sigma-70, region 4 LRR_6 PF13516.6 KII66700.1 - 0.44 10.7 0.2 0.44 10.7 0.2 7.5 10 0 0 10 10 10 0 Leucine Rich repeat Rap_GAP PF02145.15 KII66702.1 - 8.3e-20 71.1 0.5 1.3e-19 70.5 0.5 1.4 1 1 0 1 1 1 1 Rap/ran-GAP SUI1 PF01253.22 KII66702.1 - 0.054 14.0 0.0 0.078 13.5 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor SUI1 DDE_3 PF13358.6 KII66704.1 - 0.011 15.5 0.0 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 DDE superfamily endonuclease DDE_3 PF13358.6 KII66708.1 - 1.7e-06 27.8 0.0 3e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Tmem26 PF09772.9 KII66709.1 - 0.0036 16.7 1.8 0.0045 16.4 1.8 1.1 1 0 0 1 1 1 1 Transmembrane protein 26 Il13Ra_Ig PF18001.1 KII66709.1 - 0.17 12.0 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Interleukin-13 receptor subunit alpha Ig-like domain zf-CCHC PF00098.23 KII66710.1 - 6.4e-05 22.8 0.9 0.00011 22.1 0.9 1.3 1 0 0 1 1 1 1 Zinc knuckle Cnn_1N PF07989.11 KII66710.1 - 0.033 14.3 0.7 0.35 11.1 0.1 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 ATPase_2 PF01637.18 KII66710.1 - 0.068 13.1 0.2 0.095 12.6 0.2 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea zf-C2H2_10 PF16588.5 KII66710.1 - 0.19 11.5 0.7 0.43 10.4 0.7 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger DDE_3 PF13358.6 KII66714.1 - 0.0025 17.6 0.0 0.0031 17.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF777 PF05606.11 KII66716.1 - 0.13 12.0 6.5 0.11 12.2 4.1 1.8 1 1 1 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF777) DUF5377 PF17347.2 KII66719.1 - 0.01 16.2 0.9 0.015 15.6 0.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5377) THP2 PF09432.10 KII66720.1 - 0.0027 17.7 8.0 0.039 14.0 1.8 2.2 1 1 1 2 2 2 2 Tho complex subunit THP2 DUF3552 PF12072.8 KII66720.1 - 0.039 13.4 5.5 0.062 12.7 5.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) DUF4362 PF14275.6 KII66720.1 - 0.062 13.6 3.6 0.073 13.4 2.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4362) Tweety PF04906.13 KII66720.1 - 0.23 10.1 4.7 0.25 10.0 4.7 1.1 1 0 0 1 1 1 0 Tweety Rx_N PF18052.1 KII66720.1 - 0.56 10.5 4.8 0.34 11.2 1.4 2.0 1 1 1 2 2 2 0 Rx N-terminal domain CCDC-167 PF15188.6 KII66720.1 - 1.1 9.7 10.1 1.6 9.1 1.4 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 MetOD2 PF18548.1 KII66720.1 - 1.4 9.1 8.7 0.18 11.9 0.5 2.6 2 1 1 3 3 3 0 Metanogen output domain 2 COMM_domain PF07258.14 KII66720.1 - 1.7 8.8 10.3 5 7.3 0.2 3.1 1 1 2 3 3 3 0 COMM domain ABC_tran_CTD PF16326.5 KII66720.1 - 1.9 8.8 10.1 0.98 9.7 1.8 2.6 1 1 1 2 2 2 0 ABC transporter C-terminal domain Cnd3 PF12719.7 KII66722.1 - 0.00049 19.4 0.0 0.00054 19.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain PCI PF01399.27 KII66723.1 - 0.045 14.3 0.5 0.34 11.4 0.3 2.0 2 0 0 2 2 2 0 PCI domain CdiI_2 PF18593.1 KII66723.1 - 0.11 13.2 0.1 1.5 9.6 0.0 2.2 2 0 0 2 2 2 0 CdiI immunity protein DUF3884 PF13024.6 KII66726.1 - 0.031 13.8 0.0 0.058 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3884) CPP1-like PF11833.8 KII66727.1 - 0.061 13.0 0.1 0.076 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like rve PF00665.26 KII66728.1 - 8.9e-21 74.3 0.0 2.1e-20 73.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII66728.1 - 6.3e-07 29.1 0.0 1.3e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII66728.1 - 0.006 16.7 0.6 0.015 15.4 0.6 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain VCBS PF13517.6 KII66729.1 - 5.6e-05 23.6 0.3 0.0026 18.3 0.1 2.5 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII66729.1 - 0.00063 19.8 1.6 0.29 11.3 0.0 2.5 2 0 0 2 2 2 2 FG-GAP repeat DUF5381 PF17353.2 KII66729.1 - 0.047 13.5 0.2 0.15 11.8 0.3 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5381) RVT_1 PF00078.27 KII66733.1 - 7.4e-08 32.2 0.0 1.3e-07 31.3 0.0 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1948 PF09185.10 KII66733.1 - 0.063 13.1 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1948) DDE_3 PF13358.6 KII66736.1 - 2.7e-08 33.7 0.0 3.1e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH_2 PF17919.1 KII66738.1 - 8.6e-06 25.7 0.0 1.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII66738.1 - 0.019 15.0 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 Integrase zinc binding domain rve PF00665.26 KII66739.1 - 0.00014 22.1 0.1 0.00022 21.4 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII66739.1 - 0.00016 21.4 0.0 0.00031 20.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Ycf66_N PF07444.11 KII66742.1 - 0.02 15.0 0.2 0.028 14.6 0.2 1.2 1 0 0 1 1 1 0 Ycf66 protein N-terminus MID_MedPIWI PF18296.1 KII66743.1 - 0.014 15.2 0.1 0.02 14.7 0.1 1.3 1 0 0 1 1 1 0 MID domain of medPIWI IBR PF01485.21 KII66743.1 - 0.06 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain tRNA-synt_2e PF02091.15 KII66744.1 - 0.004 16.5 0.5 0.03 13.6 0.5 1.9 1 1 0 1 1 1 1 Glycyl-tRNA synthetase alpha subunit Transket_pyr PF02779.24 KII66745.1 - 4.9e-62 208.8 0.0 7.8e-62 208.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 KII66745.1 - 2e-58 197.7 0.1 3.1e-58 197.1 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 KII66745.1 - 6.7e-50 168.7 0.0 1.2e-49 167.9 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KII66745.1 - 7.5e-17 60.6 0.2 7.5e-17 60.6 0.2 2.5 3 0 0 3 3 3 1 2-oxoglutarate dehydrogenase N-terminus NHase_alpha PF02979.16 KII66745.1 - 0.053 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain Orf78 PF06024.12 KII66747.1 - 2.1 8.7 13.3 0.13 12.6 0.6 3.3 3 0 0 3 3 3 0 Orf78 (ac78) zf-CCCH PF00642.24 KII66748.1 - 3.4e-12 45.9 13.5 2.2e-07 30.6 3.7 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KII66748.1 - 2.5e-06 27.3 19.0 0.00065 19.7 5.0 2.6 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 KII66748.1 - 0.00019 21.2 14.2 0.007 16.1 4.8 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 KII66748.1 - 0.00045 20.9 9.9 0.011 16.4 2.1 2.3 1 1 1 2 2 2 2 Torus domain zf-CCCH_2 PF14608.6 KII66748.1 - 0.091 13.3 10.8 0.99 10.0 0.8 3.0 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger M16C_assoc PF08367.11 KII66749.1 - 4.2e-08 32.6 0.0 4.8e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase M16C associated Integrase_H2C2 PF17921.1 KII66749.1 - 0.0064 16.6 0.6 0.064 13.4 0.3 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain ThiJ_like PF17124.5 KII66749.1 - 0.12 12.1 0.2 0.16 11.6 0.2 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like RVT_1 PF00078.27 KII66750.1 - 1.9e-10 40.6 0.0 2.3e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Barstar PF01337.18 KII66750.1 - 0.092 12.8 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Barstar (barnase inhibitor) Integrase_H2C2 PF17921.1 KII66751.1 - 6.9e-17 61.3 0.4 1.1e-16 60.7 0.4 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain BLM_N PF16202.5 KII66751.1 - 0.029 13.5 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 N-terminal region of Bloom syndrome protein rve PF00665.26 KII66752.1 - 2.4e-20 72.9 0.0 4e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII66752.1 - 0.0011 18.8 0.0 0.0025 17.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.11 KII66753.1 - 6.5e-05 22.7 0.1 9e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII66753.1 - 0.00012 22.6 0.0 0.00016 22.2 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII66753.1 - 0.0034 18.0 0.0 0.0054 17.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 KII66753.1 - 0.046 13.5 0.1 0.12 12.1 0.1 1.7 1 1 0 1 1 1 0 Aspartyl protease E1-E2_ATPase PF00122.20 KII66755.1 - 1.1e-44 152.2 1.2 2e-43 148.0 0.0 3.1 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KII66755.1 - 5.5e-23 81.6 0.2 5.5e-23 81.6 0.2 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 KII66755.1 - 3.5e-13 49.4 0.0 7.8e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KII66755.1 - 1.2e-12 48.6 0.0 1.7e-11 44.8 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KII66755.1 - 1.5e-11 43.8 0.9 3.5e-11 42.6 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Peptidase_M4 PF01447.18 KII66755.1 - 0.2 12.2 0.0 0.47 11.0 0.0 1.6 1 0 0 1 1 1 0 Thermolysin metallopeptidase, catalytic domain Hydrolase_3 PF08282.12 KII66755.1 - 0.35 10.6 11.4 0.025 14.3 3.7 2.5 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase Integrin_beta PF00362.18 KII66759.1 - 1.1e-15 58.0 0.0 2.2e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Integrin beta chain VWA domain EGF_2 PF07974.13 KII66759.1 - 6.1e-07 29.7 54.5 0.0038 17.6 9.9 4.6 3 1 1 4 4 4 3 EGF-like domain I-EGF_1 PF18372.1 KII66759.1 - 1.4e-06 28.3 4.4 1.4e-06 28.3 4.4 5.0 5 0 0 5 5 5 3 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 KII66759.1 - 1.2e-05 25.2 8.9 1.2e-05 25.2 8.9 4.1 4 0 0 4 4 4 3 Tenascin EGF domain STOP PF05217.12 KII66759.1 - 0.037 14.3 1.7 0.037 14.3 1.7 5.1 5 0 0 5 5 5 0 STOP protein Dimer_Tnp_hAT PF05699.14 KII66760.1 - 8.5e-05 22.3 0.5 0.00023 20.9 0.1 1.8 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region LUC7 PF03194.15 KII66761.1 - 3.7e-29 102.1 0.0 2.4e-27 96.2 0.0 2.1 1 1 0 1 1 1 1 LUC7 N_terminus EGF_2 PF07974.13 KII66762.1 - 0.0004 20.7 14.2 0.001 19.4 14.2 1.8 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 KII66762.1 - 0.0009 19.2 8.0 0.0019 18.2 8.0 1.5 1 0 0 1 1 1 1 Tenascin EGF domain I-EGF_1 PF18372.1 KII66762.1 - 0.57 10.3 12.3 2.2 8.5 12.4 2.0 1 1 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 Sigma_reg_N PF13800.6 KII66762.1 - 6 7.2 7.9 2.5 8.5 4.0 2.0 1 1 1 2 2 2 0 Sigma factor regulator N-terminal DDE_Tnp_IS1595 PF12762.7 KII66763.1 - 1.1e-08 35.2 0.1 1.3e-08 35.0 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain HSP20 PF00011.21 KII66764.1 - 8.5e-20 70.8 0.9 5.7e-09 36.0 0.3 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family DUF5502 PF17606.2 KII66764.1 - 0.0082 16.8 0.1 0.08 13.7 0.0 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5502) ArsA_HSP20 PF17886.1 KII66764.1 - 0.023 14.3 0.0 0.52 9.9 0.0 2.4 2 0 0 2 2 2 0 HSP20-like domain found in ArsA HSP20 PF00011.21 KII66765.1 - 1.8e-24 85.8 0.5 6.8e-14 51.9 0.1 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII66765.1 - 0.00022 20.7 0.0 0.8 9.3 0.0 2.4 2 0 0 2 2 2 2 HSP20-like domain found in ArsA PTH2 PF01981.16 KII66766.1 - 1.9e-24 86.2 0.0 2.7e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 SIR2 PF02146.17 KII66766.1 - 0.091 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Sir2 family Cofilin_ADF PF00241.20 KII66767.1 - 6.8e-16 58.2 0.2 7.9e-16 58.0 0.2 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein AGT PF11440.8 KII66767.1 - 0.056 12.5 0.1 0.066 12.3 0.1 1.1 1 0 0 1 1 1 0 DNA alpha-glucosyltransferase AAA PF00004.29 KII66768.1 - 4.3e-41 140.4 0.1 2.6e-40 137.9 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KII66768.1 - 3e-06 26.9 0.0 6.4e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KII66768.1 - 3.8e-05 24.1 0.2 0.0024 18.3 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 KII66768.1 - 4.8e-05 23.4 0.1 0.00043 20.3 0.1 2.6 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KII66768.1 - 5.5e-05 23.5 0.0 0.0065 16.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 KII66768.1 - 0.00023 21.3 0.0 0.00055 20.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KII66768.1 - 0.0011 18.8 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 KII66768.1 - 0.0022 17.2 0.0 0.0036 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 KII66768.1 - 0.0092 16.5 0.0 0.03 14.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KII66768.1 - 0.014 15.7 0.0 0.039 14.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 KII66768.1 - 0.015 15.5 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 KII66768.1 - 0.023 13.9 0.0 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_7 PF12775.7 KII66768.1 - 0.025 14.1 0.0 0.071 12.6 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 KII66768.1 - 0.026 14.7 0.0 0.05 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KII66768.1 - 0.037 13.8 0.0 0.078 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KII66768.1 - 0.043 13.2 0.0 0.096 12.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 KII66768.1 - 0.045 13.9 0.0 0.092 12.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.20 KII66768.1 - 0.057 12.5 0.0 0.09 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 KII66768.1 - 0.064 13.0 0.0 0.19 11.4 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 KII66768.1 - 0.07 13.0 1.4 3.3 7.6 0.0 3.0 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 KII66768.1 - 0.076 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 KII66768.1 - 0.081 12.8 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KII66768.1 - 0.091 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 KII66768.1 - 0.21 10.7 0.0 0.37 9.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Cyclin_N PF00134.23 KII66771.1 - 0.00082 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ig_J_chain PF15097.6 KII66771.1 - 0.019 14.8 0.8 0.24 11.3 0.8 2.2 1 1 0 1 1 1 0 Immunoglobulin J chain Septin PF00735.18 KII66772.1 - 2.7e-78 263.1 0.1 3.1e-78 262.9 0.1 1.0 1 0 0 1 1 1 1 Septin AAA_22 PF13401.6 KII66772.1 - 0.00015 22.1 0.0 0.00057 20.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII66772.1 - 0.00029 21.3 0.0 0.00065 20.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KII66772.1 - 0.0038 17.1 0.1 0.84 9.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Roc PF08477.13 KII66772.1 - 0.013 15.7 0.0 0.037 14.2 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pox_A32 PF04665.12 KII66772.1 - 0.018 14.5 0.1 0.033 13.6 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_33 PF13671.6 KII66772.1 - 0.029 14.5 0.0 0.05 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 KII66772.1 - 0.029 13.5 4.1 2.6 7.1 0.1 2.7 2 1 0 3 3 3 0 G-protein alpha subunit ABC_tran PF00005.27 KII66772.1 - 0.054 14.0 0.1 0.12 12.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 KII66772.1 - 0.073 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 KII66772.1 - 0.17 11.6 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain DDE_3 PF13358.6 KII66774.1 - 1.2e-16 60.8 0.0 1.7e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII66774.1 - 0.036 13.7 0.0 0.043 13.5 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease tRNA-synt_2d PF01409.20 KII66774.1 - 0.071 12.6 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) HTH_23 PF13384.6 KII66775.1 - 1.4e-10 40.6 0.6 5.4e-08 32.4 0.1 2.9 3 0 0 3 3 3 1 Homeodomain-like domain PAX PF00292.18 KII66775.1 - 8.3e-10 38.7 0.4 1.3e-09 38.1 0.4 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_28 PF13518.6 KII66775.1 - 3.3e-07 30.3 0.2 7.9e-07 29.1 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 KII66775.1 - 2.8e-06 27.8 0.1 4.1e-05 24.1 0.0 2.3 1 1 1 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 KII66775.1 - 3.6e-05 23.3 0.0 8e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_29 PF13551.6 KII66775.1 - 3.7e-05 23.6 1.0 4.6e-05 23.3 0.1 1.6 2 0 0 2 2 1 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 KII66775.1 - 0.00023 20.5 0.9 0.031 13.7 0.1 2.9 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 DUF4958 PF16319.5 KII66775.1 - 0.0027 15.8 0.1 0.003 15.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4958) HTH_Tnp_1 PF01527.20 KII66775.1 - 0.0042 17.4 0.1 0.055 13.8 0.0 2.2 1 1 1 2 2 2 1 Transposase HMG_CoA_synt_N PF01154.17 KII66775.1 - 0.014 15.2 0.2 0.018 14.9 0.2 1.1 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal HTH_50 PF18024.1 KII66775.1 - 0.017 14.7 0.5 0.043 13.4 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII66775.1 - 0.019 15.2 0.8 0.047 13.9 0.1 2.0 2 0 0 2 2 2 0 Transposase TnsD PF15978.5 KII66775.1 - 0.025 13.6 0.9 0.031 13.3 0.4 1.4 1 1 0 1 1 1 0 Tn7-like transposition protein D HTH_24 PF13412.6 KII66775.1 - 0.033 13.7 1.0 0.073 12.6 0.1 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TrmB PF01978.19 KII66775.1 - 0.036 13.9 0.1 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF1699 PF08004.11 KII66775.1 - 0.059 13.1 1.7 4.2 7.1 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1699) Sigma70_r4 PF04545.16 KII66775.1 - 0.072 12.6 0.1 0.19 11.2 0.1 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 MarR_2 PF12802.7 KII66775.1 - 0.088 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 MarR family DUF359 PF04019.12 KII66775.1 - 0.1 12.2 2.0 0.25 11.0 2.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF359) KORA PF16509.5 KII66775.1 - 0.12 12.7 0.5 0.24 11.7 0.4 1.7 1 1 0 1 1 1 0 TrfB plasmid transcriptional repressor HTH_38 PF13936.6 KII66775.1 - 0.12 12.2 3.0 0.11 12.3 1.2 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII66775.1 - 0.19 11.4 0.3 0.6 9.8 0.0 2.0 2 0 0 2 2 1 0 Sigma-70, region 4 HTH_Tnp_IS1 PF12759.7 KII66775.1 - 0.37 10.4 3.6 0.2 11.3 0.4 2.2 2 0 0 2 2 2 0 InsA C-terminal domain HSP20 PF00011.21 KII66777.1 - 4.9e-17 61.9 0.9 4.7e-09 36.3 0.3 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family DUF5502 PF17606.2 KII66777.1 - 0.03 15.0 0.0 0.062 14.0 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5502) HSP20 PF00011.21 KII66779.1 - 1.4e-18 66.9 0.9 3.3e-08 33.6 0.0 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII66779.1 - 0.041 13.4 0.0 0.5 10.0 0.0 2.4 2 0 0 2 2 2 0 HSP20-like domain found in ArsA Ntox8 PF15545.6 KII66779.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial toxin 8 VPS9 PF02204.18 KII66780.1 - 6.9e-15 55.1 0.4 6.9e-15 55.1 0.4 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain zf-CCHC PF00098.23 KII66781.1 - 4.3e-06 26.5 2.5 7.8e-06 25.7 2.5 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 KII66781.1 - 0.012 15.5 3.4 0.026 14.3 3.4 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII66781.1 - 0.015 15.0 1.4 0.039 13.7 1.4 1.7 1 0 0 1 1 1 0 Zinc knuckle Asp_protease_2 PF13650.6 KII66781.1 - 0.11 13.1 0.0 0.23 12.2 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease ERG4_ERG24 PF01222.17 KII66783.1 - 0.00032 19.6 1.6 0.00034 19.5 1.6 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ERG4_ERG24 PF01222.17 KII66784.1 - 4.6e-55 187.1 8.5 5.2e-55 186.9 8.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 KII66784.1 - 0.024 14.1 0.8 0.035 13.6 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) ICMT PF04140.14 KII66784.1 - 0.063 13.7 0.5 0.2 12.1 0.0 1.8 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF4695 PF15766.5 KII66785.1 - 0.094 12.9 0.2 0.18 12.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4695) Usp PF00582.26 KII66786.1 - 5.9e-07 30.1 0.0 7.3e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Mlo PF03094.15 KII66786.1 - 0.052 11.9 0.1 0.054 11.9 0.1 1.1 1 0 0 1 1 1 0 Mlo family Usp PF00582.26 KII66787.1 - 2.6e-14 53.9 0.0 7.2e-14 52.5 0.0 1.6 1 1 0 1 1 1 1 Universal stress protein family Ribosomal_L44 PF00935.19 KII66788.1 - 4.3e-12 46.3 5.3 6.4e-12 45.8 5.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L44 DUF2999 PF11212.8 KII66791.1 - 0.086 13.1 0.0 2.5 8.5 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2999) TLD PF07534.16 KII66793.1 - 2.2e-05 24.7 0.0 5.8e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 TLD DDOST_48kD PF03345.14 KII66794.1 - 9e-77 258.6 0.1 1.1e-76 258.3 0.1 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta AMMECR1 PF01871.17 KII66795.1 - 4.8e-41 140.2 0.0 5.9e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 Pannexin_like PF12534.8 KII66798.1 - 2.1e-05 23.8 8.5 0.00011 21.4 0.1 2.3 1 1 1 2 2 2 2 Pannexin-like TM region of LRRC8 OTU PF02338.19 KII66798.1 - 0.0033 17.9 0.0 0.018 15.5 0.0 2.1 2 0 0 2 2 2 1 OTU-like cysteine protease RT_RNaseH PF17917.1 KII66802.1 - 8.5e-33 112.8 0.0 2.2e-32 111.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII66802.1 - 1.8e-32 111.3 0.0 3.8e-32 110.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII66802.1 - 8.8e-12 45.0 0.0 2e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII66802.1 - 4.6e-11 42.7 0.8 1.3e-06 28.1 0.3 2.7 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII66802.1 - 2.8e-08 34.0 0.0 6.7e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 KII66802.1 - 0.00053 20.6 0.0 0.0012 19.5 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII66802.1 - 0.0084 16.6 0.0 0.017 15.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII66802.1 - 0.02 15.2 0.0 0.059 13.7 0.0 1.8 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-H2C2 PF09337.10 KII66802.1 - 0.086 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 H2C2 zinc finger zf-CCHC PF00098.23 KII66803.1 - 0.04 14.0 2.1 0.04 14.0 2.1 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII66803.1 - 4.5 7.1 6.6 0.83 9.4 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle DDE_1 PF03184.19 KII66804.1 - 2.9e-11 43.3 0.2 2.3e-10 40.4 0.1 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease Ras PF00071.22 KII66807.1 - 2e-22 79.5 0.0 2.4e-22 79.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII66807.1 - 6.7e-20 71.5 0.0 8e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII66807.1 - 1e-11 44.6 0.1 1.2e-11 44.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII66807.1 - 1.6e-05 24.4 0.0 1.9e-05 24.1 0.0 1.0 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KII66807.1 - 4.3e-05 23.5 0.1 5.2e-05 23.3 0.1 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KII66807.1 - 7.9e-05 22.2 0.0 9.3e-05 21.9 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 KII66807.1 - 0.0048 16.6 0.3 0.0078 15.9 0.3 1.4 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 KII66807.1 - 0.006 16.3 0.1 0.0075 16.0 0.1 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KII66807.1 - 0.009 15.5 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 KII66807.1 - 0.03 14.2 0.1 0.046 13.6 0.1 1.3 1 1 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 KII66807.1 - 0.031 14.8 0.1 0.035 14.6 0.1 1.2 1 0 0 1 1 1 0 ABC transporter PRK PF00485.18 KII66807.1 - 0.052 13.3 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.6 KII66807.1 - 0.055 13.7 0.0 0.056 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 KII66807.1 - 0.06 12.5 0.3 0.31 10.2 0.0 1.8 1 1 1 2 2 2 0 G-protein alpha subunit GTP_EFTU PF00009.27 KII66807.1 - 0.063 12.8 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain TniB PF05621.11 KII66807.1 - 0.067 12.6 0.1 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Bacterial TniB protein DLIC PF05783.11 KII66807.1 - 0.075 11.8 0.0 0.084 11.7 0.0 1.0 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_23 PF13476.6 KII66807.1 - 0.076 13.5 0.3 0.09 13.3 0.2 1.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KII66807.1 - 0.082 13.3 0.0 0.095 13.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 KII66807.1 - 0.088 12.3 0.1 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 KII66807.1 - 0.12 12.1 0.1 1.4 8.7 0.1 1.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 KII66807.1 - 0.13 12.0 0.1 0.28 11.0 0.0 1.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 KII66807.1 - 0.14 12.2 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MCM PF00493.23 KII66807.1 - 0.15 11.1 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 MCM P-loop domain Ploopntkinase3 PF18751.1 KII66807.1 - 0.16 11.9 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 SGS PF05002.15 KII66808.1 - 8.6e-22 77.0 0.4 2.4e-21 75.6 0.4 1.7 1 0 0 1 1 1 1 SGS domain CS PF04969.16 KII66808.1 - 3e-12 47.4 0.0 5.8e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 CS domain Mso1_Sec1_bdg PF14475.6 KII66809.1 - 0.7 9.5 2.7 1.7 8.3 2.7 1.7 1 0 0 1 1 1 0 Sec1-binding region of Mso1 Yuri_gagarin PF15934.5 KII66810.1 - 0.0073 16.2 1.1 0.008 16.1 1.1 1.1 1 0 0 1 1 1 1 Yuri gagarin YEATS PF03366.16 KII66810.1 - 0.038 14.0 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 YEATS family DDE_3 PF13358.6 KII66812.1 - 2.1e-07 30.8 0.0 2.4e-07 30.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Sortilin_C PF15901.5 KII66813.1 - 9.9e-17 61.8 5.0 2.1e-16 60.7 5.0 1.6 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII66813.1 - 8.9e-09 34.6 3.2 1e-07 31.1 0.0 2.9 4 0 0 4 4 4 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII66813.1 - 0.00038 20.0 1.3 0.5 10.6 0.3 3.3 2 0 0 2 2 2 2 BNR/Asp-box repeat Cyt_b-c1_8 PF10890.8 KII66816.1 - 0.064 13.7 0.1 0.15 12.5 0.1 1.6 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 RVT_1 PF00078.27 KII66818.1 - 1.2e-23 83.8 0.0 1.7e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Biotin_carb_C PF02785.19 KII66818.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 1 0 1 1 1 0 Biotin carboxylase C-terminal domain zf-CCHC PF00098.23 KII66819.1 - 0.0068 16.4 1.0 0.0068 16.4 1.0 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_10 PF16588.5 KII66819.1 - 0.0085 15.8 1.5 0.0085 15.8 1.5 2.2 3 0 0 3 3 3 1 C2H2 zinc-finger NifW PF03206.14 KII66819.1 - 0.084 13.4 0.3 0.62 10.6 0.1 2.2 2 0 0 2 2 2 0 Nitrogen fixation protein NifW RT_RNaseH_2 PF17919.1 KII66822.1 - 2.6e-09 37.0 0.0 3.3e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF2244 PF10003.9 KII66824.1 - 0.12 12.1 0.9 0.16 11.6 0.9 1.2 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) gag-asp_proteas PF13975.6 KII66825.1 - 0.066 13.8 0.0 0.19 12.3 0.0 1.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Fmp27_WPPW PF10359.9 KII66825.1 - 0.11 11.3 0.7 0.15 10.9 0.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain HTH_23 PF13384.6 KII66828.1 - 0.00013 21.7 0.2 0.0018 18.0 0.0 2.6 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.6 KII66828.1 - 0.056 13.6 0.2 0.19 11.9 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_32 PF13565.6 KII66828.1 - 0.089 13.4 0.0 0.62 10.7 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain TnsD PF15978.5 KII66828.1 - 0.17 10.9 0.0 0.23 10.4 0.0 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Sigma70_r4_2 PF08281.12 KII66828.1 - 0.17 11.6 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 RestrictionMunI PF11407.8 KII66829.1 - 0.015 15.0 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 Type II restriction enzyme MunI DUF484 PF04340.12 KII66829.1 - 0.081 12.6 0.0 0.086 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF484 Frag1 PF10277.9 KII66830.1 - 0.013 15.0 5.1 0.023 14.2 5.1 1.5 1 1 0 1 1 1 0 Frag1/DRAM/Sfk1 family Pox_A14 PF05767.12 KII66830.1 - 0.014 15.6 8.2 0.24 11.6 0.7 2.1 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 DUF4064 PF13273.6 KII66830.1 - 0.7 10.2 13.5 9.4 6.6 13.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) DUF202 PF02656.15 KII66830.1 - 2 8.9 7.4 21 5.7 7.4 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DDE_Tnp_IS1595 PF12762.7 KII66831.1 - 0.0019 18.2 0.1 0.0043 17.1 0.1 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain PCMT PF01135.19 KII66832.1 - 9.5e-59 198.7 0.0 1.2e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KII66832.1 - 5.9e-05 22.9 0.0 8.1e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KII66832.1 - 0.00059 20.5 0.0 0.0015 19.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII66832.1 - 0.0039 17.8 0.2 0.012 16.2 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 KII66832.1 - 0.0044 17.0 0.0 0.012 15.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 KII66832.1 - 0.022 14.4 0.1 0.067 12.8 0.1 1.9 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW TehB PF03848.14 KII66832.1 - 0.029 13.8 0.1 0.062 12.7 0.0 1.5 1 1 0 1 1 1 0 Tellurite resistance protein TehB PrmA PF06325.13 KII66832.1 - 0.04 13.3 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KII66832.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 KII66833.1 - 1.1e-19 71.1 0.0 1.3e-19 70.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KII66833.1 - 0.001 18.9 0.0 0.0013 18.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KII66833.1 - 0.0029 17.1 0.0 0.0042 16.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.6 KII66833.1 - 0.0053 16.8 0.0 0.0065 16.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII66833.1 - 0.01 15.7 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 KII66833.1 - 0.19 11.5 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 Lysine methyltransferase N2227 PF07942.12 KII66837.1 - 2.5e-59 200.7 0.3 3.2e-59 200.3 0.3 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.12 KII66837.1 - 0.007 17.1 0.0 0.059 14.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII66837.1 - 0.18 12.5 0.0 0.85 10.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltr_RsmF_N PF17125.5 KII66838.1 - 1.6e-11 44.5 0.0 2.4e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltr_RsmB-F PF01189.17 KII66838.1 - 2.9e-08 33.6 0.0 4.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KII66838.1 - 0.13 12.4 0.0 0.3 11.2 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 KII66839.1 - 0.00052 19.7 1.4 0.0016 18.1 0.0 2.2 2 1 0 2 2 2 1 16S rRNA methyltransferase RsmB/F AA_permease_2 PF13520.6 KII66840.1 - 7.7e-38 130.4 53.4 1e-37 130.0 53.4 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII66840.1 - 8.4e-21 74.1 51.8 1.2e-20 73.6 51.8 1.1 1 0 0 1 1 1 1 Amino acid permease N2227 PF07942.12 KII66841.1 - 9.7e-67 225.0 1.3 1.2e-66 224.7 1.3 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_31 PF13847.6 KII66841.1 - 0.0004 20.2 0.2 0.018 14.8 0.1 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KII66841.1 - 0.00041 21.1 0.0 0.0015 19.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII66841.1 - 0.00097 19.7 0.3 0.015 15.9 0.3 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII66841.1 - 0.018 14.9 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 KII66841.1 - 0.035 14.8 0.0 2.6 8.8 0.0 2.8 2 0 0 2 2 2 0 Methyltransferase domain Tcp11 PF05794.13 KII66841.1 - 0.068 12.3 0.3 0.1 11.7 0.3 1.2 1 0 0 1 1 1 0 T-complex protein 11 NNMT_PNMT_TEMT PF01234.17 KII66841.1 - 0.076 12.2 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family LCM PF04072.14 KII66842.1 - 1.1e-27 97.2 0.0 2.3e-27 96.1 0.0 1.6 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase MTS PF05175.14 KII66842.1 - 0.0023 17.5 0.0 0.0037 16.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ribosomal_S13 PF00416.22 KII66844.1 - 1.9e-46 157.6 3.2 2.2e-46 157.4 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 IMS_HHH PF11798.8 KII66844.1 - 0.032 14.6 0.5 0.079 13.3 0.5 1.7 1 0 0 1 1 1 0 IMS family HHH motif Hepar_II_III_N PF16889.5 KII66844.1 - 0.063 12.5 0.0 0.085 12.1 0.0 1.1 1 0 0 1 1 1 0 Heparinase II/III N-terminus Cpn60_TCP1 PF00118.24 KII66845.1 - 5.4e-68 229.8 0.5 6e-68 229.7 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PrpR_N PF06506.11 KII66845.1 - 0.072 12.7 0.3 0.28 10.7 0.0 2.1 3 0 0 3 3 3 0 Propionate catabolism activator Peptidase_C65 PF10275.9 KII66845.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase C65 Otubain PucR PF07905.11 KII66845.1 - 0.14 12.4 0.0 0.39 11.0 0.0 1.7 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family RNA_pol_Rpb2_7 PF04560.20 KII66848.1 - 8.3e-35 119.1 0.1 9.4e-35 118.9 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 C1_2 PF03107.16 KII66848.1 - 0.072 13.4 2.2 0.22 11.9 2.2 1.8 1 1 0 1 1 1 0 C1 domain RNA_POL_M_15KD PF02150.16 KII66848.1 - 0.074 12.9 1.2 0.13 12.2 0.5 1.8 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit Cript PF10235.9 KII66848.1 - 0.088 13.4 3.1 0.091 13.3 0.1 2.0 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT LANC_like PF05147.13 KII66849.1 - 0.082 11.5 0.0 0.12 10.9 0.0 1.2 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein Telomerase_RBD PF12009.8 KII66850.1 - 2.3e-18 66.6 3.7 6.2e-18 65.2 3.7 1.8 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 KII66850.1 - 0.0023 17.5 0.9 0.068 12.7 0.0 3.0 3 1 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) TUDOR_5 PF18359.1 KII66851.1 - 1.3e-10 40.8 0.0 2.4e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 Tudor_3 PF18115.1 KII66851.1 - 4.2e-05 23.3 0.0 7.5e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain LBR_tudor PF09465.10 KII66851.1 - 0.00045 20.0 0.0 0.00083 19.1 0.0 1.5 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain DUF4537 PF15057.6 KII66851.1 - 0.028 14.4 0.0 0.056 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DUF1325 PF07039.11 KII66851.1 - 0.047 13.8 0.0 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 SGF29 tudor-like domain FERM_N PF09379.10 KII66852.1 - 5e-14 52.0 1.6 9.3e-14 51.1 0.1 2.3 3 0 0 3 3 3 1 FERM N-terminal domain FERM_C PF09380.10 KII66852.1 - 6.9e-14 52.0 0.4 6.9e-14 52.0 0.4 2.1 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KII66852.1 - 4.9e-13 49.5 0.1 2.5e-12 47.3 0.0 2.2 2 0 0 2 2 2 1 FERM central domain FA PF08736.11 KII66852.1 - 5.8e-06 26.3 4.9 5.8e-06 26.3 4.9 2.1 2 0 0 2 2 2 1 FERM adjacent (FA) PilZ PF07238.14 KII66852.1 - 0.0063 16.8 0.1 0.036 14.4 0.0 2.3 3 0 0 3 3 3 1 PilZ domain Tudor_2 PF18104.1 KII66852.1 - 0.017 14.8 0.9 0.044 13.5 0.1 2.2 2 0 0 2 2 2 0 Jumonji domain-containing protein 2A Tudor domain P4Ha_N PF08336.11 KII66853.1 - 9.2e-12 45.1 0.2 1.6e-11 44.3 0.2 1.4 1 1 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region AAA_lid_1 PF17857.1 KII66853.1 - 0.035 14.3 0.8 0.16 12.2 0.1 2.1 2 0 0 2 2 2 0 AAA+ lid domain 2OG-FeII_Oxy_3 PF13640.6 KII66854.1 - 4.7e-08 33.8 0.0 8.2e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zinc_ribbon_13 PF09855.9 KII66855.1 - 0.047 13.9 0.5 0.11 12.7 0.1 1.9 2 1 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DUF5427 PF10310.9 KII66855.1 - 0.14 11.1 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) A2L_zn_ribbon PF08792.10 KII66855.1 - 0.65 9.8 0.1 0.65 9.8 0.1 2.8 3 1 0 3 3 3 0 A2L zinc ribbon domain DEAD PF00270.29 KII66857.1 - 8e-08 32.2 0.1 2e-07 30.9 0.1 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase TK PF00265.18 KII66857.1 - 0.01 15.7 0.2 0.023 14.5 0.1 1.6 1 1 0 1 1 1 0 Thymidine kinase AAA PF00004.29 KII66857.1 - 0.03 14.7 0.0 0.039 14.4 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 KII66857.1 - 0.044 13.8 0.1 0.064 13.3 0.1 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit XhlA PF10779.9 KII66857.1 - 1.7 8.9 5.3 0.22 11.8 1.0 1.8 2 0 0 2 2 2 0 Haemolysin XhlA DEAD PF00270.29 KII66858.1 - 0.0004 20.2 0.0 0.00047 20.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 KII66858.1 - 0.0017 17.5 0.0 0.002 17.2 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein 7TM_GPCR_Srt PF10321.9 KII66858.1 - 0.01 14.8 0.9 0.012 14.6 0.9 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srt ResIII PF04851.15 KII66858.1 - 0.068 13.2 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Sec63 PF02889.16 KII66859.1 - 0.0054 15.9 0.6 0.058 12.5 0.6 2.6 1 1 0 1 1 1 1 Sec63 Brl domain Paf1 PF03985.13 KII66860.1 - 1.8e-19 70.1 1.4 2.2e-19 69.8 1.4 1.0 1 0 0 1 1 1 1 Paf1 Adenyl_transf PF04439.12 KII66860.1 - 0.016 14.4 0.6 0.022 13.9 0.6 1.3 1 0 0 1 1 1 0 Streptomycin adenylyltransferase FliM PF02154.15 KII66861.1 - 0.12 12.3 1.1 2.6 7.9 0.0 2.2 2 0 0 2 2 2 0 Flagellar motor switch protein FliM HipN PF18253.1 KII66862.1 - 0.56 9.9 2.9 1.1 9.0 0.0 2.8 3 0 0 3 3 3 0 Hsp70-interacting protein N N-terminal domain NT5C PF06941.12 KII66864.1 - 0.1 12.5 0.1 0.3 10.9 0.0 1.7 1 1 1 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Stealth_CR4 PF17103.5 KII66868.1 - 0.028 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 AAA_lid_7 PF17867.1 KII66869.1 - 0.082 13.1 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 Midasin AAA lid domain DSHCT PF08148.12 KII66871.1 - 1.3e-47 161.5 0.1 3.5e-47 160.1 0.1 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 KII66871.1 - 1.5e-39 136.6 4.5 2.5e-39 135.8 4.5 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 KII66871.1 - 2.4e-20 73.1 0.1 8.5e-20 71.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII66871.1 - 3.5e-06 27.3 0.0 2.2e-05 24.8 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII66871.1 - 0.00016 21.8 0.0 0.00048 20.2 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KII66871.1 - 0.031 14.6 0.0 0.078 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 KII66871.1 - 0.094 11.8 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein HC2 PF07382.11 KII66874.1 - 2.9e-11 43.8 9.6 3.5e-11 43.6 9.6 1.1 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 MULE PF10551.9 KII66875.1 - 6.2e-16 58.6 0.0 1.6e-15 57.3 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.16 KII66875.1 - 8.8e-11 41.8 3.8 1.6e-10 41.0 2.7 1.9 2 0 0 2 2 2 1 FLYWCH zinc finger domain zf-CCHC_5 PF14787.6 KII66876.1 - 0.021 14.5 3.9 0.037 13.7 3.9 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger MULE PF10551.9 KII66878.1 - 1.5e-06 28.5 0.1 2.7e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 MULE transposase domain LMP PF04778.12 KII66878.1 - 0.073 13.0 0.3 0.1 12.5 0.3 1.2 1 0 0 1 1 1 0 LMP repeated region RFX5_N PF18326.1 KII66878.1 - 0.099 12.4 0.3 0.21 11.4 0.3 1.5 1 0 0 1 1 1 0 RFX5 N-terminal domain ATP-synt_D PF01813.17 KII66879.1 - 9.5e-57 192.0 1.1 1.2e-56 191.6 1.1 1.1 1 0 0 1 1 1 1 ATP synthase subunit D RhoGAP PF00620.27 KII66879.1 - 0.068 13.0 0.6 0.17 11.7 0.4 1.7 2 0 0 2 2 2 0 RhoGAP domain Ribosomal_L6e PF01159.19 KII66879.1 - 0.16 12.5 3.0 0.32 11.6 3.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L6e Thioredoxin PF00085.20 KII66880.1 - 1e-42 144.3 0.1 2.5e-19 69.2 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 KII66880.1 - 2.7e-17 63.3 7.5 9.3e-14 51.8 4.2 2.7 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 KII66880.1 - 1.9e-08 34.7 2.7 0.013 16.0 0.2 4.0 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KII66880.1 - 2.3e-08 34.3 0.6 0.0013 19.0 0.0 3.5 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 KII66880.1 - 4.5e-07 29.8 0.7 0.0034 17.3 0.1 3.1 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_7 PF13899.6 KII66880.1 - 2e-06 27.9 0.7 0.023 14.9 0.0 3.8 3 1 0 3 3 3 2 Thioredoxin-like Thioredoxin_9 PF14595.6 KII66880.1 - 5e-05 23.1 0.1 3.2 7.5 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin TraF PF13728.6 KII66880.1 - 0.00014 21.8 0.1 0.3 10.9 0.0 3.0 3 0 0 3 3 3 2 F plasmid transfer operon protein Redoxin PF08534.10 KII66880.1 - 0.0012 18.6 4.0 0.085 12.6 0.4 3.6 4 0 0 4 4 4 1 Redoxin Glutaredoxin PF00462.24 KII66880.1 - 0.018 15.3 0.1 3 8.1 0.0 2.9 2 0 0 2 2 2 0 Glutaredoxin DUF5612 PF18462.1 KII66880.1 - 0.23 11.2 0.0 0.39 10.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5612) zf-C2H2_4 PF13894.6 KII66880.1 - 0.84 10.6 5.8 0.62 11.1 0.6 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger WD40 PF00400.32 KII66881.1 - 1.6e-33 114.2 3.1 2.3e-05 25.1 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII66881.1 - 1.7e-11 44.3 0.1 0.03 14.6 0.0 5.3 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KII66881.1 - 0.00028 20.9 0.2 0.081 12.8 0.0 2.5 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KII66881.1 - 0.0013 18.2 0.0 1.1 8.5 0.0 2.7 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 KII66881.1 - 0.0053 15.5 0.4 1.3 7.6 0.0 2.5 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 KII66881.1 - 0.025 13.1 0.0 0.082 11.4 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain RVT_1 PF00078.27 KII66882.1 - 0.00043 19.9 0.7 0.0011 18.6 0.2 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII66883.1 - 6.5e-22 77.9 0.0 1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII66883.1 - 5.9e-07 29.2 0.0 1.6e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII66883.1 - 0.00088 19.3 0.0 0.0031 17.6 0.0 1.9 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain ATG11 PF10377.9 KII66883.1 - 0.011 15.8 0.1 0.021 14.9 0.1 1.4 1 0 0 1 1 1 0 Autophagy-related protein 11 HTH_23 PF13384.6 KII66884.1 - 6.6e-09 35.3 0.2 3.7e-06 26.6 0.0 2.9 2 1 0 2 2 2 2 Homeodomain-like domain HTH_29 PF13551.6 KII66884.1 - 3.1e-07 30.3 0.1 6.5e-06 26.1 0.0 2.4 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 KII66884.1 - 8e-07 28.7 0.1 0.0007 19.3 0.0 3.7 4 0 0 4 4 4 1 Helix-turn-helix domain HTH_28 PF13518.6 KII66884.1 - 1.3e-06 28.5 0.0 1.9e-05 24.7 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 KII66884.1 - 5.8e-05 23.6 0.0 0.00022 21.7 0.0 1.9 1 1 1 2 2 2 1 Homeodomain-like domain PAX PF00292.18 KII66884.1 - 0.0017 18.3 0.1 0.003 17.5 0.1 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_Tc3_2 PF01498.18 KII66884.1 - 0.0087 16.3 0.1 0.025 14.8 0.0 1.9 2 0 0 2 2 2 1 Transposase Ribosomal_S21 PF01165.20 KII66884.1 - 0.011 15.4 0.0 0.11 12.2 0.1 2.2 2 0 0 2 2 2 0 Ribosomal protein S21 HTH_33 PF13592.6 KII66884.1 - 0.023 14.4 0.0 0.048 13.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HTH_11 PF08279.12 KII66884.1 - 0.03 14.3 0.2 0.065 13.2 0.2 1.6 1 0 0 1 1 1 0 HTH domain HTH_Crp_2 PF13545.6 KII66884.1 - 0.031 14.2 0.1 0.11 12.5 0.0 1.9 2 1 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_Tnp_IS630 PF01710.16 KII66884.1 - 0.034 14.2 0.5 0.098 12.7 0.3 1.8 1 1 0 2 2 2 0 Transposase HTH_7 PF02796.15 KII66884.1 - 0.038 14.1 1.5 0.27 11.3 0.1 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase TrmB PF01978.19 KII66884.1 - 0.054 13.4 0.1 0.37 10.7 0.0 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB LIM PF00412.22 KII66885.1 - 2.5e-47 158.9 49.3 2.2e-12 47.0 6.3 4.3 4 0 0 4 4 4 4 LIM domain Sgf11 PF08209.11 KII66885.1 - 0.23 11.1 0.1 0.23 11.1 0.1 7.3 9 0 0 9 9 9 0 Sgf11 (transcriptional regulation protein) DDE_3 PF13358.6 KII66886.1 - 4.5e-10 39.5 0.0 5.4e-10 39.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3791 PF12668.7 KII66886.1 - 0.02 14.9 0.0 0.54 10.4 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3791) Thioredoxin PF00085.20 KII66887.1 - 2.7e-20 72.3 0.0 3.5e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KII66887.1 - 0.0029 17.9 0.1 1.9 8.9 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 KII66887.1 - 0.015 15.7 0.0 0.16 12.4 0.0 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain OST3_OST6 PF04756.13 KII66887.1 - 0.081 12.3 0.0 0.14 11.5 0.0 1.4 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family RWP-RK PF02042.15 KII66887.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 RWP-RK domain DDE_Tnp_IS1595 PF12762.7 KII66888.1 - 0.0012 18.9 0.6 0.0023 18.0 0.3 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain Integrase_H2C2 PF17921.1 KII66889.1 - 4.3e-13 49.2 0.1 1.3e-12 47.6 0.1 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII66889.1 - 0.0011 19.2 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain CBM65_1 PF18259.1 KII66889.1 - 0.091 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding module 65 domain 1 RT_RNaseH_2 PF17919.1 KII66890.1 - 3.4e-14 52.7 0.4 1.9e-13 50.3 0.4 2.0 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII66890.1 - 3e-11 43.5 0.8 2.3e-09 37.5 0.1 2.6 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase DUF5475 PF17569.2 KII66890.1 - 0.087 13.1 0.1 0.15 12.4 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5475) gag-asp_proteas PF13975.6 KII66891.1 - 3.1e-06 27.6 0.0 4.9e-06 27.0 0.0 1.5 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII66891.1 - 6.4e-06 26.7 0.0 1e-05 26.1 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII66891.1 - 0.013 15.8 0.0 0.024 14.9 0.0 1.5 1 1 0 1 1 1 0 Retroviral aspartyl protease HTH_19 PF12844.7 KII66891.1 - 0.026 14.5 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain TAF4 PF05236.14 KII66895.1 - 1.4e-06 28.2 5.8 0.00077 19.3 5.5 2.4 1 1 1 2 2 2 2 Transcription initiation factor TFIID component TAF4 family HTH_46 PF15977.5 KII66898.1 - 6.8e-27 93.3 0.2 1.2e-26 92.5 0.2 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA binding cNMP_binding PF00027.29 KII66898.1 - 0.00021 21.3 0.1 0.00049 20.1 0.0 1.6 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain MarR_2 PF12802.7 KII66898.1 - 0.014 15.3 0.1 0.031 14.2 0.1 1.5 1 0 0 1 1 1 0 MarR family HTH_46 PF15977.5 KII66899.1 - 8e-26 89.9 0.1 1.3e-25 89.2 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA binding cNMP_binding PF00027.29 KII66899.1 - 0.00046 20.2 0.0 0.0012 18.9 0.0 1.7 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain MarR_2 PF12802.7 KII66899.1 - 0.002 17.9 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 KII66899.1 - 0.026 14.4 0.0 0.064 13.2 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Vps54_N PF10475.9 KII66899.1 - 0.032 13.5 0.0 0.039 13.2 0.0 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Rrf2 PF02082.20 KII66899.1 - 0.047 14.1 0.1 0.082 13.3 0.1 1.3 1 0 0 1 1 1 0 Transcriptional regulator DUF2250 PF10007.9 KII66899.1 - 0.12 12.5 0.3 0.26 11.4 0.2 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) zf-met PF12874.7 KII66900.1 - 6.3e-12 45.5 13.9 7e-07 29.4 0.6 3.6 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KII66900.1 - 4.2e-07 30.1 13.5 6.3e-06 26.3 0.6 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KII66900.1 - 0.00012 22.4 17.2 0.064 13.6 5.1 3.7 2 2 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.12 KII66900.1 - 0.092 12.9 0.4 0.092 12.9 0.4 3.4 4 0 0 4 4 4 0 DBF zinc finger zf-C2H2_4 PF13894.6 KII66900.1 - 4.4 8.4 14.5 2.4 9.2 1.6 4.1 3 0 0 3 3 3 0 C2H2-type zinc finger DDE_Tnp_IS1595 PF12762.7 KII66902.1 - 0.0015 18.6 0.0 0.0026 17.8 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain Kunitz_BPTI PF00014.23 KII66903.1 - 0.021 15.1 8.3 0.021 15.1 8.3 2.0 2 0 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain vMSA PF00695.19 KII66905.1 - 0.047 12.8 2.4 0.048 12.8 2.4 1.0 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus RTTN_N PF14726.6 KII66907.1 - 0.13 13.0 0.2 0.42 11.4 0.1 1.9 2 1 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning RT_RNaseH PF17917.1 KII66908.1 - 6.6e-18 64.9 0.3 3e-17 62.8 0.1 2.0 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII66908.1 - 2.4e-14 53.2 1.4 2.7e-08 33.7 0.4 2.4 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII66908.1 - 0.00019 21.0 0.2 0.9 9.0 0.0 2.9 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) DAHP_snth_FXD PF18152.1 KII66908.1 - 0.0085 15.9 0.0 0.055 13.3 0.0 2.2 2 0 0 2 2 2 1 DAHP synthase ferredoxin-like domain CDPS PF16715.5 KII66909.1 - 0.028 14.1 0.1 0.031 13.9 0.1 1.1 1 0 0 1 1 1 0 Cyclodipeptide synthase NIF PF03031.18 KII66910.1 - 0.069 12.9 0.0 0.085 12.6 0.0 1.2 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase Phage_Integr_2 PF13009.6 KII66911.1 - 0.019 14.1 0.1 0.027 13.6 0.1 1.1 1 0 0 1 1 1 0 Putative phage integrase GRAM PF02893.20 KII66911.1 - 0.019 14.8 0.2 0.047 13.6 0.0 1.8 2 0 0 2 2 2 0 GRAM domain Serpin PF00079.20 KII66913.1 - 7.6e-35 120.9 4.3 6.3e-34 117.9 4.3 2.0 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) zf-CCHC PF00098.23 KII66914.1 - 0.0002 21.2 3.1 0.0004 20.3 3.1 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 KII66914.1 - 0.32 11.0 0.1 0.32 11.0 0.1 2.0 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 KII66915.1 - 1.4e-05 25.3 0.0 3e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 Integrase core domain Serpin PF00079.20 KII66916.1 - 1.7e-46 159.2 0.0 1.3e-41 143.1 0.0 2.1 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) CDC45 PF02724.14 KII66916.1 - 0.54 8.5 15.3 0.72 8.1 15.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 KII66916.1 - 1.9 7.2 4.2 2.7 6.7 4.2 1.2 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 KII66916.1 - 4 5.5 26.7 5.4 5.1 26.7 1.1 1 0 0 1 1 1 0 Nop14-like family Serpin PF00079.20 KII66918.1 - 2.2e-47 162.1 1.2 9.8e-43 146.9 1.4 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) Nop14 PF04147.12 KII66918.1 - 3.4 5.8 20.7 6.1 4.9 20.7 1.3 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 KII66918.1 - 5 6.5 22.1 9.2 5.6 22.1 1.3 1 0 0 1 1 1 0 SDA1 RT_RNaseH_2 PF17919.1 KII66919.1 - 5.7e-09 35.9 0.0 7.6e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Serpin PF00079.20 KII66920.1 - 2.5e-06 27.0 0.0 2.5e-06 27.0 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII66922.1 - 0.00048 19.5 0.0 0.0044 16.4 0.0 2.0 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DAP3 PF10236.9 KII66922.1 - 0.16 11.1 0.2 0.21 10.7 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Nop14 PF04147.12 KII66922.1 - 6.4 4.9 10.3 7.4 4.7 10.3 1.0 1 0 0 1 1 1 0 Nop14-like family Serpin PF00079.20 KII66923.1 - 2.3e-19 70.0 0.0 2.7e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII66924.1 - 2.6e-19 69.8 0.2 4.8e-18 65.6 0.2 2.0 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) CDC45 PF02724.14 KII66924.1 - 3.6 5.7 7.0 4.6 5.4 7.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Serpin PF00079.20 KII66925.1 - 1.2e-08 34.7 0.0 1.4e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RVT_1 PF00078.27 KII66926.1 - 1.2e-11 44.6 0.1 3.2e-11 43.2 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 KII66926.1 - 0.0072 16.5 0.1 0.026 14.7 0.0 1.8 1 1 1 2 2 2 1 Spumavirus aspartic protease (A9) RT_RNaseH PF17917.1 KII66927.1 - 6.2e-39 132.5 0.0 1.2e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII66927.1 - 6.8e-38 128.7 0.0 1.1e-37 128.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII66927.1 - 3.6e-05 23.4 0.0 0.00021 20.9 0.0 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cas_Cmr5 PF09701.10 KII66927.1 - 0.016 15.5 0.2 5.8 7.2 0.3 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cmr5) rve PF00665.26 KII66928.1 - 4.3e-24 85.0 0.0 5.6e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII66928.1 - 0.00072 19.3 0.0 0.0018 18.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII66928.1 - 0.024 14.9 0.0 0.03 14.6 0.0 1.1 1 0 0 1 1 1 0 DDE domain Transcript_VP30 PF11507.8 KII66928.1 - 0.093 12.8 0.1 0.42 10.7 0.0 1.9 1 1 1 2 2 2 0 Ebola virus-specific transcription factor VP30 DUF1932 PF09130.11 KII66931.1 - 0.084 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) Sec34 PF04136.15 KII66934.1 - 0.0082 16.0 2.7 0.0082 16.0 2.7 4.5 5 2 1 6 6 6 1 Sec34-like family Syntaxin-6_N PF09177.11 KII66934.1 - 0.016 15.8 0.4 0.016 15.8 0.4 3.7 5 1 0 5 5 5 0 Syntaxin 6, N-terminal MbeD_MobD PF04899.12 KII66934.1 - 0.65 10.2 5.1 2.7 8.2 0.2 3.5 4 0 0 4 4 4 0 MbeD/MobD like TMF_TATA_bd PF12325.8 KII66934.1 - 6.9 6.9 13.7 0.92 9.7 2.0 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding RT_RNaseH_2 PF17919.1 KII66940.1 - 1.6e-07 31.3 0.0 4.7e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII66940.1 - 3e-07 30.6 0.0 1.1e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 KII66940.1 - 0.00046 20.4 0.0 0.0013 19.0 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase TRAPP PF04051.16 KII66940.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Transport protein particle (TRAPP) component F-box PF00646.33 KII66942.1 - 0.073 13.0 0.6 0.23 11.4 0.1 2.0 2 0 0 2 2 2 0 F-box domain RANK_CRD_2 PF18278.1 KII66944.1 - 0.12 12.5 0.1 0.22 11.7 0.1 1.4 1 0 0 1 1 1 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 zf-HC5HC2H_2 PF13832.6 KII66945.1 - 0.049 13.8 0.0 0.081 13.1 0.0 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain Fib_alpha PF08702.10 KII66946.1 - 0.053 13.7 7.5 0.066 13.4 7.5 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1043 PF06295.12 KII66946.1 - 0.13 12.2 1.3 1.6 8.7 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DDE_3 PF13358.6 KII66948.1 - 8.1e-06 25.7 0.1 0.004 16.9 0.1 2.8 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF4618 PF15397.6 KII66949.1 - 0.0053 16.2 3.1 0.014 14.9 2.4 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4618) FliJ PF02050.16 KII66949.1 - 0.0097 16.1 5.5 0.17 12.1 2.2 2.6 1 1 2 3 3 3 1 Flagellar FliJ protein DUF749 PF05370.11 KII66949.1 - 0.048 13.8 1.0 5.2 7.2 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF749) Spectrin PF00435.21 KII66949.1 - 0.1 13.1 2.9 1.5 9.3 2.9 2.2 1 1 0 1 1 1 0 Spectrin repeat Noelin-1 PF12308.8 KII66949.1 - 0.14 12.2 5.9 0.86 9.6 0.2 2.0 1 1 1 2 2 2 0 Neurogenesis glycoprotein DUF1910 PF08928.10 KII66949.1 - 0.15 12.1 3.8 0.28 11.2 0.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1910) DUF948 PF06103.11 KII66949.1 - 0.17 12.1 0.0 4.5 7.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Imm51 PF15595.6 KII66949.1 - 0.47 10.4 2.7 2.2 8.3 0.3 2.4 2 1 0 2 2 2 0 Immunity protein 51 Exonuc_VII_L PF02601.15 KII66949.1 - 0.7 9.4 5.3 0.82 9.2 5.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-C4H2 PF10146.9 KII66949.1 - 2.1 8.6 6.9 2.7 8.3 6.0 1.6 1 1 1 2 2 2 0 Zinc finger-containing protein CorA PF01544.18 KII66949.1 - 2.3 7.5 8.0 6.4 6.0 8.0 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Peptidase_M3_N PF08439.10 KII66949.1 - 4.3 7.7 6.1 1.3 9.4 1.6 2.4 2 1 0 2 2 2 0 Oligopeptidase F DDE_3 PF13358.6 KII66952.1 - 1.7e-07 31.1 0.0 1.7e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease CUB PF00431.20 KII66953.1 - 1.1e-22 80.4 1.6 1.1e-22 80.4 1.6 4.0 5 0 0 5 5 5 1 CUB domain Nup96 PF12110.8 KII66954.1 - 0.00031 20.0 0.2 0.00067 18.9 0.2 1.5 1 0 0 1 1 1 1 Nuclear protein 96 TPR_1 PF00515.28 KII66954.1 - 0.0056 16.5 0.3 0.068 13.0 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KII66954.1 - 0.025 14.7 0.0 0.39 11.0 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII66955.1 - 3.7e-05 23.5 1.6 0.68 10.2 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KII66955.1 - 0.00046 20.8 0.0 0.9 10.2 0.0 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KII66955.1 - 0.00064 19.4 5.3 0.043 13.7 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII66955.1 - 0.0032 17.7 0.8 2.5 8.4 0.0 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KII66955.1 - 0.0048 17.6 0.1 29 5.8 0.0 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KII66955.1 - 0.007 16.6 2.5 0.007 16.6 2.5 4.2 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KII66955.1 - 0.048 13.9 12.5 13 6.3 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 KII66955.1 - 0.048 13.7 8.5 0.12 12.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KII66955.1 - 0.52 10.8 2.4 6.7 7.3 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KII66955.1 - 1.1 10.1 4.9 16 6.4 0.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat LIM PF00412.22 KII66956.1 - 9.1e-11 41.8 7.4 2e-10 40.7 7.4 1.6 1 0 0 1 1 1 1 LIM domain SH3_9 PF14604.6 KII66956.1 - 9.5e-05 22.2 0.0 0.00016 21.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KII66956.1 - 0.0085 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 SH3 domain zinc_ribbon_11 PF11682.8 KII66956.1 - 0.03 14.3 0.4 0.072 13.1 0.4 1.6 1 0 0 1 1 1 0 Probable zinc-ribbon Sigma70_r4 PF04545.16 KII66957.1 - 0.00091 18.7 0.0 0.0022 17.5 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 CENP-B_N PF04218.13 KII66957.1 - 0.0022 17.6 0.0 0.0053 16.4 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 KII66957.1 - 0.0041 16.9 0.0 0.0087 15.8 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 KII66957.1 - 0.0092 16.1 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MRPL52 PF18699.1 KII66959.1 - 0.00053 20.1 0.1 0.00068 19.8 0.1 1.3 1 0 0 1 1 1 1 Mitoribosomal protein mL52 Spermine_synth PF01564.17 KII66960.1 - 9.6e-53 178.4 0.1 1.7e-52 177.6 0.1 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KII66960.1 - 8.5e-17 60.8 0.9 3.5e-16 58.8 0.1 2.3 2 0 0 2 2 2 1 Spermidine synthase tetramerisation domain Methyltransf_31 PF13847.6 KII66960.1 - 3.7e-06 26.8 0.0 5.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KII66960.1 - 0.00084 20.0 0.0 0.0015 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KII66960.1 - 0.011 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 KII66960.1 - 0.023 14.2 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_12 PF08242.12 KII66960.1 - 0.044 14.5 0.0 0.087 13.6 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 KII66960.1 - 0.085 13.5 0.0 0.16 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.11 KII66960.1 - 0.092 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 KII66960.1 - 0.16 11.5 0.2 0.4 10.3 0.2 1.7 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW CBFD_NFYB_HMF PF00808.23 KII66961.1 - 1.4e-14 54.1 0.2 2.6e-14 53.2 0.2 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KII66961.1 - 0.0004 20.7 0.0 0.00049 20.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.13 KII66961.1 - 0.0065 16.9 1.0 0.012 16.1 1.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Ribosomal_L3 PF00297.22 KII66962.1 - 0.00014 21.0 0.0 0.00021 20.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 Chordopox_A30L PF06015.12 KII66963.1 - 0.38 10.6 4.9 0.69 9.8 4.3 1.8 1 1 1 2 2 2 0 Chordopoxvirus A30L protein Misat_Tub_SegII PF10644.9 KII66963.1 - 0.38 11.1 2.8 0.33 11.3 0.4 1.9 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain LSM PF01423.22 KII66964.1 - 3.7e-18 65.0 0.2 4.9e-18 64.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KII66964.1 - 0.0058 16.3 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Hfq protein FmiP_Thoc5 PF09766.9 KII66967.1 - 0.14 11.4 0.1 0.18 11.0 0.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 RT_RNaseH PF17917.1 KII66968.1 - 4.1e-33 113.8 0.0 8.5e-33 112.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII66968.1 - 2.5e-31 107.7 0.0 4.9e-31 106.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII66968.1 - 1.1e-20 74.0 0.0 3.3e-20 72.5 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII66968.1 - 5.9e-15 55.1 0.0 1.2e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Peptidase_A2E PF12382.8 KII66969.1 - 0.00075 19.5 0.4 0.0017 18.4 0.4 1.6 1 1 0 1 1 1 1 Retrotransposon peptidase gag-asp_proteas PF13975.6 KII66969.1 - 0.1 13.2 0.0 0.23 12.0 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_3 PF13917.6 KII66970.1 - 0.001 19.0 11.9 0.016 15.1 1.6 2.3 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 KII66970.1 - 0.027 14.6 13.3 0.13 12.3 1.4 2.2 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 KII66970.1 - 0.048 13.4 0.9 0.048 13.4 0.9 1.6 2 0 0 2 2 2 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 KII66970.1 - 0.28 11.0 9.6 3 7.7 2.5 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 KII66970.1 - 5.4 6.8 9.4 0.43 10.3 4.4 1.8 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger Helitron_like_N PF14214.6 KII66974.1 - 3.3e-09 37.2 4.6 5.7e-07 29.9 0.0 3.3 3 1 1 4 4 4 2 Helitron helicase-like domain at N-terminus CemA PF03040.14 KII66975.1 - 0.005 16.8 0.1 0.0074 16.2 0.1 1.2 1 0 0 1 1 1 1 CemA family Hemagglutinin PF00509.18 KII66975.1 - 0.019 13.4 0.1 0.023 13.1 0.1 1.1 1 0 0 1 1 1 0 Haemagglutinin CALCOCO1 PF07888.11 KII66975.1 - 0.021 13.7 0.9 0.027 13.4 0.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like bZIP_1 PF00170.21 KII66975.1 - 0.043 13.9 1.2 0.094 12.8 1.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor Epimerase PF01370.21 KII66976.1 - 5.8e-47 160.2 0.0 7.7e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KII66976.1 - 1.9e-11 44.0 0.0 1.6e-10 40.9 0.0 1.9 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 KII66976.1 - 3.4e-07 29.6 0.0 8.3e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KII66976.1 - 1.6e-06 27.5 0.0 0.0022 17.2 0.0 3.0 2 1 1 3 3 3 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 KII66976.1 - 4.8e-05 22.5 0.1 0.00059 18.9 0.0 2.1 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KII66976.1 - 0.045 12.9 0.0 0.27 10.4 0.0 1.9 1 1 0 2 2 2 0 Male sterility protein BAF250_C PF12031.8 KII66976.1 - 0.072 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa DnaB PF00772.21 KII66978.1 - 0.033 14.3 3.1 0.078 13.1 0.3 2.9 3 0 0 3 3 3 0 DnaB-like helicase N terminal domain RIH_assoc PF08454.11 KII66978.1 - 1.9 8.4 7.5 0.7 9.8 0.2 3.8 2 1 1 3 3 3 0 RyR and IP3R Homology associated Claudin_2 PF13903.6 KII66984.1 - 0.0014 18.4 6.3 0.0014 18.4 6.3 2.0 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Transmemb_17 PF09799.9 KII66984.1 - 1.3 9.7 13.8 0.028 15.0 6.1 2.1 2 1 0 2 2 2 0 Predicted membrane protein DUF2231 PF09990.9 KII66984.1 - 2.6 8.5 7.5 0.084 13.3 0.5 2.1 3 0 0 3 3 3 0 Predicted membrane protein (DUF2231) DUF3784 PF12650.7 KII66984.1 - 4 7.7 15.0 0.58 10.4 6.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF3784) ACR_tran PF00873.19 KII66985.1 - 0.12 10.0 1.3 0.15 9.7 1.3 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Fumarate_red_C PF02300.17 KII66985.1 - 0.37 10.9 3.4 0.23 11.5 1.4 1.6 2 0 0 2 2 2 0 Fumarate reductase subunit C DUF4064 PF13273.6 KII66988.1 - 0.0033 17.7 1.0 0.0033 17.7 1.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4064) Sdh_cyt PF01127.22 KII66988.1 - 0.056 13.5 6.1 0.21 11.7 6.1 1.8 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit WRW PF10206.9 KII66988.1 - 0.087 13.2 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f Pox_EPC_I2-L1 PF12575.8 KII66988.1 - 0.53 10.6 4.1 0.34 11.2 0.5 2.2 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 DHHC PF01529.20 KII66988.1 - 0.57 10.3 3.5 0.91 9.6 3.5 1.5 1 1 0 1 1 1 0 DHHC palmitoyltransferase Virul_fac_BrkB PF03631.15 KII66988.1 - 1.2 8.7 11.1 0.57 9.8 1.7 2.0 1 1 1 2 2 2 0 Virulence factor BrkB DUF2207 PF09972.9 KII66988.1 - 3 6.5 7.4 0.29 9.8 0.1 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Gp49 PF05973.14 KII66989.1 - 0.19 11.9 0.1 0.19 11.9 0.1 1.7 2 0 0 2 2 2 0 Phage derived protein Gp49-like (DUF891) DUF3980 PF13140.6 KII66991.1 - 0.57 10.7 6.7 0.2 12.1 3.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3980) DGC PF08859.11 KII66993.1 - 0.012 15.7 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 DGC domain Lamp PF01299.17 KII66995.1 - 0.009 15.9 0.2 0.017 15.0 0.1 1.6 1 1 1 2 2 2 1 Lysosome-associated membrane glycoprotein (Lamp) MULE PF10551.9 KII66998.1 - 1.1e-13 51.4 1.6 1.3e-13 51.1 1.6 1.1 1 0 0 1 1 1 1 MULE transposase domain LysM PF01476.20 KII66999.1 - 4.8e-09 36.1 0.3 3.3e-08 33.5 0.1 2.2 2 0 0 2 2 2 1 LysM domain TOH_N PF12549.8 KII66999.1 - 0.63 10.0 2.5 0.75 9.7 0.0 2.1 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal Salp15 PF12115.8 KII67003.1 - 0.058 13.8 0.2 0.38 11.2 0.1 1.9 1 1 1 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Glutaredoxin PF00462.24 KII67004.1 - 1.1e-17 64.0 0.1 2.1e-17 63.1 0.1 1.5 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 KII67004.1 - 2.8e-05 24.1 0.0 4.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain DUF836 PF05768.14 KII67004.1 - 0.016 15.6 0.1 0.024 15.1 0.1 1.4 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 KII67004.1 - 0.17 12.4 0.5 0.72 10.3 0.5 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain GOLGA2L5 PF15070.6 KII67006.1 - 4.8e-05 22.2 47.9 0.0023 16.7 28.7 3.1 1 1 2 3 3 3 3 Putative golgin subfamily A member 2-like protein 5 DUF1192 PF06698.11 KII67006.1 - 0.0063 16.5 1.5 0.98 9.5 0.5 3.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1192) DUF5320 PF17253.2 KII67006.1 - 0.026 15.6 5.4 1.2 10.2 0.4 3.3 2 0 0 2 2 2 0 Family of unknown function (DUF5320) TSC22 PF01166.18 KII67006.1 - 0.048 14.0 1.1 0.048 14.0 1.1 7.8 4 3 4 8 8 8 0 TSC-22/dip/bun family AAA_22 PF13401.6 KII67007.1 - 6.5e-12 45.9 0.0 1.5e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII67007.1 - 3.3e-08 34.1 0.0 5.4e-06 26.9 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA PF00004.29 KII67007.1 - 4.8e-07 30.3 0.0 1.5e-06 28.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KII67007.1 - 9.7e-07 28.9 0.0 1.8e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 KII67007.1 - 1.6e-06 27.8 0.1 4.7e-06 26.2 0.1 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 KII67007.1 - 2e-06 27.9 1.3 1.6e-05 25.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain Cdc6_C PF09079.11 KII67007.1 - 2.5e-05 24.2 0.0 7.6e-05 22.6 0.0 1.8 2 0 0 2 2 1 1 CDC6, C terminal winged helix domain AAA_5 PF07728.14 KII67007.1 - 8e-05 22.7 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KII67007.1 - 0.00019 22.0 0.2 0.00094 19.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 KII67007.1 - 0.002 17.3 0.0 0.0042 16.3 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Viral_helicase1 PF01443.18 KII67007.1 - 0.0045 16.8 0.7 0.0065 16.2 0.0 1.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 KII67007.1 - 0.0081 16.3 0.2 0.021 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 KII67007.1 - 0.0089 15.3 1.2 0.0092 15.3 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) RNA12 PF10443.9 KII67007.1 - 0.011 14.5 2.5 0.021 13.6 0.0 2.5 3 0 0 3 3 3 0 RNA12 protein AAA_19 PF13245.6 KII67007.1 - 0.012 15.9 0.0 0.043 14.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KII67007.1 - 0.022 14.6 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 KII67007.1 - 0.029 14.3 3.3 0.035 14.0 0.4 2.5 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 KII67007.1 - 0.034 13.9 0.0 0.21 11.3 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain SRPRB PF09439.10 KII67007.1 - 0.041 13.3 0.1 0.041 13.3 0.1 2.4 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 KII67007.1 - 0.058 13.3 0.0 0.2 11.6 0.0 1.9 1 1 0 1 1 1 0 NTPase DUF2610 PF11020.8 KII67007.1 - 0.08 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2610) TrwB_AAD_bind PF10412.9 KII67007.1 - 0.096 11.6 0.0 0.78 8.6 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.6 KII67007.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KII67007.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Sigma54_activ_2 PF14532.6 KII67007.1 - 0.12 12.5 0.9 0.36 10.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Serpin PF00079.20 KII67008.1 - 5.5e-22 78.6 0.9 6.5e-22 78.3 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DAD PF02109.16 KII67008.1 - 0.097 13.0 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 DAD family DDE_Tnp_IS1595 PF12762.7 KII67009.1 - 0.00068 19.7 0.0 0.00071 19.6 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain PSY3 PF16836.5 KII67009.1 - 0.023 14.2 0.1 0.024 14.1 0.1 1.1 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description Serpin PF00079.20 KII67011.1 - 5.2e-29 101.7 2.1 5.7e-29 101.6 2.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII67012.1 - 4.8e-20 72.2 0.0 5.3e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sugar_tr PF00083.24 KII67013.1 - 1.1e-27 97.1 13.5 1.3e-27 96.8 13.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1656 PF07869.12 KII67013.1 - 0.015 15.3 1.0 0.015 15.3 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) Clc-like PF07062.12 KII67013.1 - 0.038 13.4 0.3 0.038 13.4 0.3 1.8 3 0 0 3 3 3 0 Clc-like Sugar_tr PF00083.24 KII67014.1 - 0.0062 15.5 0.0 0.0065 15.4 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Serpin PF00079.20 KII67015.1 - 2.3e-56 191.7 9.9 2.7e-40 138.8 3.9 2.0 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) Lge1 PF11488.8 KII67016.1 - 0.042 14.0 0.1 0.093 12.9 0.1 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 DUF2689 PF10894.8 KII67016.1 - 0.066 13.0 0.6 0.2 11.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2689) Serpin PF00079.20 KII67019.1 - 1.4e-45 156.2 0.3 1.8e-45 155.9 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII67021.1 - 5e-13 49.1 0.0 5.4e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII67022.1 - 5.7e-39 134.5 4.1 6.5e-39 134.3 4.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1128 PF06569.11 KII67023.1 - 0.064 13.2 0.1 0.22 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1128) DUF3105 PF11303.8 KII67024.1 - 0.063 13.4 0.1 0.28 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3105) SNAP PF14938.6 KII67025.1 - 1.3e-09 37.9 1.1 1.7e-09 37.5 1.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 KII67025.1 - 0.02 14.3 0.0 0.044 13.1 0.0 1.5 1 1 0 1 1 1 0 MalT-like TPR region TPR_1 PF00515.28 KII67025.1 - 0.063 13.1 12.6 0.52 10.2 0.4 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KII67025.1 - 0.1 12.3 4.4 8.3 6.2 0.2 3.6 3 1 0 3 3 3 0 TPR repeat TPR_8 PF13181.6 KII67025.1 - 0.39 11.0 4.3 12 6.4 0.6 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII67025.1 - 0.41 10.9 10.4 3.2 8.1 0.2 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat DDE_Tnp_IS1595 PF12762.7 KII67026.1 - 8.3e-15 55.1 0.1 1.5e-14 54.3 0.1 1.6 1 1 0 1 1 1 1 ISXO2-like transposase domain SesA PF17107.5 KII67029.1 - 0.079 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases BACK PF07707.15 KII67029.1 - 0.087 12.9 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch DUF4371 PF14291.6 KII67030.1 - 2.4e-12 47.0 0.1 2.4e-12 47.0 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) DUF5587 PF17825.1 KII67031.1 - 0.015 12.6 0.6 0.016 12.5 0.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5587) DUF2660 PF10859.8 KII67032.1 - 0.1 13.1 1.3 12 6.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2660) RT_RNaseH PF17917.1 KII67035.1 - 8.6e-37 125.6 0.0 1.8e-36 124.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII67035.1 - 1.1e-35 121.6 0.0 2.5e-35 120.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67035.1 - 3.7e-27 95.3 0.1 8.8e-27 94.1 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII67035.1 - 1.2e-16 60.6 1.8 2.9e-16 59.3 1.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII67035.1 - 2.2e-09 37.5 0.0 4.6e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII67035.1 - 5.6e-05 23.4 0.1 0.00013 22.2 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII67035.1 - 6e-05 23.5 0.1 0.00013 22.5 0.1 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII67035.1 - 0.0039 17.8 0.0 0.008 16.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII67035.1 - 0.019 15.1 2.1 0.019 15.1 2.1 3.0 2 0 0 2 2 2 0 Zinc knuckle Rogdi_lz PF10259.9 KII67035.1 - 0.03 13.8 0.0 0.27 10.7 0.0 2.2 2 0 0 2 2 2 0 Rogdi leucine zipper containing protein RVP_2 PF08284.11 KII67035.1 - 0.066 13.0 0.4 0.16 11.7 0.1 1.8 2 0 0 2 2 2 0 Retroviral aspartyl protease zf-CCHC_3 PF13917.6 KII67035.1 - 1.4 8.9 9.8 67 3.6 9.8 2.6 1 1 0 1 1 1 0 Zinc knuckle MLVIN_C PF18697.1 KII67036.1 - 0.004 17.2 0.3 0.015 15.4 0.1 1.9 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Sedlin_N PF04628.13 KII67036.1 - 0.044 13.9 0.5 0.14 12.3 0.2 1.9 2 0 0 2 2 2 0 Sedlin, N-terminal conserved region Streptin-Immun PF11083.8 KII67036.1 - 0.065 13.6 0.2 0.12 12.8 0.2 1.3 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein Sortilin-Vps10 PF15902.5 KII67037.1 - 6.6e-06 25.2 2.3 0.00015 20.7 0.1 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, LRR_RI_capping PF18779.1 KII67037.1 - 0.045 13.4 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Capping Ribonuclease inhibitor Leucine Rich Repeat Cthe_2159 PF14262.6 KII67038.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate-binding domain-containing protein Cthe_2159 Corazonin PF17308.2 KII67040.1 - 0.29 11.5 4.1 0.24 11.7 2.2 1.9 2 0 0 2 2 2 0 Pro-corazonin ERK-JNK_inhib PF15002.6 KII67041.1 - 0.024 14.4 0.1 0.053 13.2 0.1 1.6 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor SNAP PF14938.6 KII67042.1 - 3.6e-07 29.9 0.1 5.2e-07 29.4 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 KII67042.1 - 0.11 12.2 1.6 1 9.1 1.8 2.3 2 0 0 2 2 2 0 TPR repeat Propep_M14 PF02244.16 KII67043.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Carboxypeptidase activation peptide HABP4_PAI-RBP1 PF04774.15 KII67044.1 - 0.00054 20.8 10.6 0.0013 19.6 2.1 3.4 2 1 0 2 2 2 1 Hyaluronan / mRNA binding family DUF4050 PF13259.6 KII67044.1 - 0.2 12.0 8.0 0.19 12.1 5.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4050) Asp_Glu_race PF01177.22 KII67046.1 - 0.019 14.8 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 Asp/Glu/Hydantoin racemase RRM_1 PF00076.22 KII67052.1 - 5.5e-17 61.4 0.0 1.6e-16 59.9 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KII67052.1 - 0.073 13.1 0.1 0.25 11.4 0.1 1.8 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KII67052.1 - 0.12 12.2 0.0 1.7 8.6 0.0 2.0 2 0 0 2 2 2 0 Occluded RNA-recognition motif Nab6_mRNP_bdg PF10567.9 KII67052.1 - 0.14 11.6 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 RNA-recognition motif DUF812 PF05667.11 KII67054.1 - 0.0016 17.4 6.4 0.0018 17.3 6.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF4298 PF14131.6 KII67054.1 - 0.0031 17.4 2.1 0.0031 17.4 2.1 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4298) IFT57 PF10498.9 KII67054.1 - 0.0044 16.0 8.3 0.0055 15.7 8.3 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Goodbye PF17109.5 KII67054.1 - 0.0062 17.0 1.0 0.01 16.3 1.0 1.3 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain Spc7 PF08317.11 KII67054.1 - 0.0074 15.2 7.4 0.0081 15.1 7.4 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF4763 PF15960.5 KII67054.1 - 0.0098 15.2 4.6 0.023 14.0 4.7 1.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4763) Leu_zip PF15294.6 KII67054.1 - 0.01 15.4 7.4 0.012 15.2 7.4 1.0 1 0 0 1 1 1 0 Leucine zipper PI3K_1B_p101 PF10486.9 KII67054.1 - 0.011 13.6 2.3 0.011 13.5 2.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1664 PF07889.12 KII67054.1 - 0.012 15.6 2.2 0.024 14.7 2.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Prominin PF05478.11 KII67054.1 - 0.013 13.5 3.6 0.014 13.4 3.6 1.0 1 0 0 1 1 1 0 Prominin T3SS_needle_E PF08988.10 KII67054.1 - 0.013 15.6 1.0 0.021 14.9 0.2 1.7 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle Apolipoprotein PF01442.18 KII67054.1 - 0.014 15.2 5.4 0.029 14.2 5.4 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain COG2 PF06148.11 KII67054.1 - 0.016 15.3 4.5 0.059 13.5 4.6 1.7 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 IL6 PF00489.17 KII67054.1 - 0.018 14.6 0.4 0.02 14.4 0.4 1.2 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family Mod_r PF07200.13 KII67054.1 - 0.026 14.6 7.7 0.039 14.1 7.6 1.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Exonuc_VII_L PF02601.15 KII67054.1 - 0.026 14.1 6.4 0.03 13.9 6.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mst1_SARAH PF11629.8 KII67054.1 - 0.029 14.4 1.3 0.15 12.1 0.0 2.6 1 1 1 2 2 2 0 C terminal SARAH domain of Mst1 FAM76 PF16046.5 KII67054.1 - 0.03 13.7 3.9 0.033 13.6 3.9 1.1 1 0 0 1 1 1 0 FAM76 protein Med21 PF11221.8 KII67054.1 - 0.041 14.1 3.8 0.054 13.8 3.8 1.2 1 0 0 1 1 1 0 Subunit 21 of Mediator complex Baculo_PEP_C PF04513.12 KII67054.1 - 0.047 13.7 0.7 0.077 13.0 0.7 1.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cob_adeno_trans PF01923.18 KII67054.1 - 0.048 13.8 1.6 0.05 13.7 1.6 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF4239 PF14023.6 KII67054.1 - 0.084 12.6 1.1 0.098 12.4 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Syntaxin-6_N PF09177.11 KII67054.1 - 0.093 13.3 3.0 0.18 12.4 3.0 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal YtxH PF12732.7 KII67054.1 - 0.1 13.2 2.2 3.2 8.4 0.1 2.2 1 1 1 2 2 2 0 YtxH-like protein Uso1_p115_C PF04871.13 KII67054.1 - 0.1 13.0 7.1 0.12 12.7 6.7 1.3 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Abhydrolase_8 PF06259.12 KII67054.1 - 0.12 11.9 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Sec8_exocyst PF04048.14 KII67054.1 - 0.13 12.1 4.3 0.15 12.0 4.3 1.2 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF883 PF05957.13 KII67054.1 - 0.15 12.6 2.4 0.19 12.4 0.9 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Syntaxin_2 PF14523.6 KII67054.1 - 0.16 12.4 6.3 0.3 11.5 6.3 1.6 1 1 0 1 1 1 0 Syntaxin-like protein DUF2663 PF10864.8 KII67054.1 - 0.16 12.3 4.5 0.4 11.1 4.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2663) OmpH PF03938.14 KII67054.1 - 0.18 12.1 10.5 0.52 10.6 10.5 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) GIT_CC PF16559.5 KII67054.1 - 0.18 11.7 3.3 0.17 11.8 1.8 1.8 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Atg14 PF10186.9 KII67054.1 - 0.22 10.6 6.9 0.26 10.3 6.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 KII67054.1 - 0.32 10.3 4.8 0.39 10.0 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tup_N PF08581.10 KII67054.1 - 0.47 10.8 10.2 3 8.2 3.2 2.2 1 1 1 2 2 2 0 Tup N-terminal Spc24 PF08286.11 KII67054.1 - 0.73 10.1 6.1 0.22 11.8 3.2 1.5 2 0 0 2 2 1 0 Spc24 subunit of Ndc80 Fzo_mitofusin PF04799.13 KII67054.1 - 0.81 9.2 7.6 1.6 8.3 7.6 1.4 1 1 0 1 1 1 0 fzo-like conserved region Fib_alpha PF08702.10 KII67054.1 - 0.91 9.7 7.8 4.3 7.5 7.8 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Oleosin PF01277.17 KII67054.1 - 1.5 8.6 2.5 3.3 7.5 0.2 1.9 1 1 1 2 2 2 0 Oleosin LMBR1 PF04791.16 KII67054.1 - 2.9 6.7 4.5 3.3 6.5 4.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein USP8_interact PF08941.10 KII67054.1 - 3.3 7.5 6.3 0.34 10.7 1.9 1.6 2 0 0 2 2 2 0 USP8 interacting MM_CoA_mutase PF01642.22 KII67055.1 - 1.1e-53 182.5 0.1 1.5e-53 182.2 0.1 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase MM_CoA_mutase PF01642.22 KII67056.1 - 1.3e-50 172.4 0.2 1.5e-50 172.3 0.2 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 KII67057.1 - 6.8e-11 42.3 0.1 8.4e-11 42.0 0.1 1.1 1 0 0 1 1 1 1 B12 binding domain IMPDH PF00478.25 KII67057.1 - 0.009 15.0 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain V_ATPase_I PF01496.19 KII67058.1 - 2 6.2 7.1 2.7 5.8 7.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF948 PF06103.11 KII67058.1 - 5 7.4 6.0 29 5.0 0.0 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 KII67058.1 - 8.5 5.6 10.0 0.36 10.1 1.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Anemone_cytotox PF06369.12 KII67059.1 - 0.067 12.8 0.1 0.086 12.5 0.1 1.2 1 0 0 1 1 1 0 Sea anemone cytotoxic protein MRP-S24 PF14955.6 KII67060.1 - 2.4e-25 89.1 0.3 3.6e-25 88.5 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S24 FBA_3 PF08268.12 KII67060.1 - 0.052 13.5 0.2 0.084 12.8 0.2 1.4 1 0 0 1 1 1 0 F-box associated domain NifQ PF04891.12 KII67060.1 - 0.24 11.8 0.5 0.75 10.1 0.1 1.9 2 0 0 2 2 2 0 NifQ PRMT5_C PF17286.2 KII67061.1 - 6.3e-46 156.5 0.9 1.1e-45 155.6 0.9 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 KII67061.1 - 5e-41 140.4 0.4 2.8e-29 102.2 0.0 2.3 1 1 1 2 2 2 2 PRMT5 arginine-N-methyltransferase PRMT5_TIM PF17285.2 KII67061.1 - 1.3e-08 34.3 0.2 1.3e-07 31.1 0.2 2.1 1 1 0 1 1 1 1 PRMT5 TIM barrel domain PIN_4 PF13638.6 KII67062.1 - 4.4e-09 36.7 0.1 7.5e-09 36.0 0.1 1.4 1 0 0 1 1 1 1 PIN domain EST1_DNA_bind PF10373.9 KII67062.1 - 0.076 12.5 9.4 0.008 15.7 4.4 1.9 2 0 0 2 2 2 0 Est1 DNA/RNA binding domain GAS PF13851.6 KII67064.1 - 0.00078 18.8 8.7 0.0026 17.1 3.8 2.2 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding SseB_C PF14581.6 KII67064.1 - 0.0021 18.1 0.1 0.0061 16.6 0.1 1.8 1 0 0 1 1 1 1 SseB protein C-terminal domain MA3 PF02847.17 KII67064.1 - 0.0032 17.4 0.9 0.0032 17.4 0.9 1.8 2 0 0 2 2 2 1 MA3 domain Mod_r PF07200.13 KII67064.1 - 0.0043 17.2 12.6 0.033 14.3 0.9 3.2 1 1 2 3 3 3 1 Modifier of rudimentary (Mod(r)) protein HAP1_N PF04849.13 KII67064.1 - 0.009 15.3 12.2 0.022 14.0 3.4 2.1 2 0 0 2 2 2 2 HAP1 N-terminal conserved region Fib_alpha PF08702.10 KII67064.1 - 0.01 16.0 2.6 0.01 16.0 2.6 3.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family OmpH PF03938.14 KII67064.1 - 0.013 15.9 2.0 0.39 11.0 0.2 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Vir_act_alpha_C PF10400.9 KII67064.1 - 0.016 15.9 4.7 1.2 9.9 0.2 2.8 3 0 0 3 3 3 0 Virulence activator alpha C-term DUF4201 PF13870.6 KII67064.1 - 0.082 12.6 10.0 0.12 12.1 3.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 KII67064.1 - 0.11 11.9 4.6 0.19 11.0 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HMMR_N PF15905.5 KII67064.1 - 0.16 11.4 10.2 0.69 9.3 0.4 2.3 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Csm1_N PF18504.1 KII67064.1 - 0.2 12.0 8.5 1.3 9.5 2.2 3.2 3 0 0 3 3 3 0 Csm1 N-terminal domain Bacillus_HBL PF05791.11 KII67064.1 - 0.25 11.1 4.4 1.4 8.7 1.2 2.7 2 2 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ZapB PF06005.12 KII67064.1 - 0.38 11.2 12.9 0.73 10.3 1.3 3.4 2 1 1 3 3 3 0 Cell division protein ZapB Prefoldin PF02996.17 KII67064.1 - 0.53 10.2 7.3 5.3 7.0 0.8 3.4 3 0 0 3 3 3 0 Prefoldin subunit CdvA PF18822.1 KII67064.1 - 0.9 9.4 7.4 1 9.2 0.4 3.1 2 1 0 2 2 2 0 CdvA-like coiled-coil domain AKNA PF12443.8 KII67064.1 - 0.95 10.2 5.3 1.5 9.6 0.1 2.9 2 1 1 3 3 3 0 AT-hook-containing transcription factor DUF1548 PF07579.11 KII67064.1 - 2 8.8 6.8 0.87 9.9 0.9 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1548) Cortex-I_coil PF09304.10 KII67064.1 - 2.4 8.4 11.8 0.9 9.8 0.9 3.1 3 1 1 4 4 4 0 Cortexillin I, coiled coil Uso1_p115_C PF04871.13 KII67064.1 - 2.6 8.4 9.5 14 6.1 0.5 2.6 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Swi5 PF07061.11 KII67064.1 - 3.7 7.7 11.1 2.7 8.2 0.4 3.4 2 1 1 3 3 3 0 Swi5 GIT_CC PF16559.5 KII67064.1 - 5.5 6.9 7.8 24 4.9 1.1 3.4 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1664 PF07889.12 KII67064.1 - 5.5 7.1 6.8 5.3 7.1 0.2 3.1 3 1 1 4 4 3 0 Protein of unknown function (DUF1664) HALZ PF02183.18 KII67064.1 - 7 7.0 12.0 18 5.7 1.3 4.1 5 1 0 5 5 4 0 Homeobox associated leucine zipper DUF4298 PF14131.6 KII67064.1 - 7.2 6.6 7.7 21 5.2 0.3 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4298) zf-C3HC4_3 PF13920.6 KII67065.1 - 1.7e-07 31.0 10.8 3.5e-07 30.0 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KII67065.1 - 8.5e-07 28.7 13.6 8.5e-07 28.7 13.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII67065.1 - 1.8e-06 27.7 10.7 3.7e-06 26.7 10.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KII67065.1 - 0.00012 21.9 13.0 0.00034 20.5 13.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KII67065.1 - 0.00015 21.6 12.2 0.00015 21.6 12.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII67065.1 - 0.0014 18.9 11.9 0.0014 18.9 11.9 1.8 2 0 0 2 2 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KII67065.1 - 0.0034 17.4 8.1 0.0096 15.9 8.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger CmlA_N PF18456.1 KII67065.1 - 0.097 12.0 2.7 0.19 11.0 2.7 1.5 1 1 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain MnmE_helical PF12631.7 KII67065.1 - 0.22 11.6 7.3 0.3 11.2 7.3 1.2 1 0 0 1 1 1 0 MnmE helical domain zf-RING_6 PF14835.6 KII67065.1 - 0.28 11.1 4.9 0.54 10.2 4.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein PEPcase PF00311.17 KII67065.1 - 0.36 8.9 6.2 0.43 8.6 6.2 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase HAUS6_N PF14661.6 KII67065.1 - 1 8.9 8.4 1.6 8.3 8.4 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Mod_r PF07200.13 KII67065.1 - 1.2 9.3 14.2 0.54 10.4 11.2 1.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein AAA_32 PF13654.6 KII67065.1 - 1.4 7.6 10.0 1.6 7.4 10.0 1.1 1 0 0 1 1 1 0 AAA domain CorA PF01544.18 KII67065.1 - 1.6 7.9 4.7 2.2 7.5 4.7 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein zf-RING_4 PF14570.6 KII67065.1 - 1.6 8.5 12.2 4.8 7.1 12.2 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Snapin_Pallidin PF14712.6 KII67065.1 - 2.2 8.8 7.8 0.74 10.3 3.8 2.1 1 1 1 2 2 2 0 Snapin/Pallidin zf-rbx1 PF12678.7 KII67065.1 - 2.4 8.5 13.9 0.16 12.3 7.5 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KII67065.1 - 4.2 7.6 16.4 29 4.9 11.7 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING HTH_23 PF13384.6 KII67066.1 - 4.2e-08 32.7 0.0 7.5e-05 22.4 0.0 2.5 2 1 0 2 2 2 2 Homeodomain-like domain HTH_33 PF13592.6 KII67066.1 - 2.2e-07 30.4 0.1 4e-07 29.6 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 KII67066.1 - 2.1e-05 25.0 0.1 4.4e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII67066.1 - 0.00013 22.1 0.6 0.00038 20.6 0.0 1.9 2 0 0 2 2 2 1 Transposase HTH_29 PF13551.6 KII67066.1 - 0.002 18.1 0.0 0.018 15.1 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn helix HTH_24 PF13412.6 KII67066.1 - 0.0022 17.5 0.1 0.035 13.6 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Tnp_1_2 PF13022.6 KII67066.1 - 0.0024 18.0 0.6 0.004 17.3 0.3 1.5 2 0 0 2 2 2 1 Helix-turn-helix of insertion element transposase B5 PF03484.15 KII67066.1 - 0.0031 17.8 0.0 0.0057 16.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase B5 domain PAX PF00292.18 KII67066.1 - 0.0039 17.1 0.0 0.0055 16.6 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain CENP-B_N PF04218.13 KII67066.1 - 0.0061 16.2 0.1 0.15 11.7 0.0 2.4 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain DUF2470 PF10615.9 KII67066.1 - 0.011 16.4 0.0 0.015 15.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) HTH_IclR PF09339.10 KII67066.1 - 0.018 14.8 0.0 0.22 11.3 0.0 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_28 PF13518.6 KII67066.1 - 0.019 15.1 0.0 1.8 8.8 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII67066.1 - 0.026 14.2 0.0 0.21 11.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 MarR_2 PF12802.7 KII67066.1 - 0.048 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_1 PF00126.27 KII67066.1 - 0.11 12.5 0.2 0.51 10.3 0.0 2.2 2 1 1 3 3 3 0 Bacterial regulatory helix-turn-helix protein, lysR family TrmB PF01978.19 KII67066.1 - 0.11 12.4 0.0 0.59 10.1 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB RRM_1 PF00076.22 KII67067.1 - 3.3e-20 71.7 0.1 2.7e-08 33.5 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_Hakai PF18408.1 KII67068.1 - 2.6e-11 43.0 0.5 5.3e-11 42.0 0.5 1.5 1 0 0 1 1 1 1 C2H2 Hakai zinc finger domain zf-C3HC4_3 PF13920.6 KII67068.1 - 3.5e-05 23.6 2.4 7.8e-05 22.5 2.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KII67068.1 - 0.011 15.6 2.4 0.011 15.6 2.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII67068.1 - 0.022 14.6 3.7 0.053 13.4 3.7 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf_ZIC PF18366.1 KII67068.1 - 0.046 13.8 0.3 0.099 12.8 0.3 1.6 1 0 0 1 1 1 0 Zic proteins zinc finger domain DUF2321 PF10083.9 KII67068.1 - 0.11 12.1 6.3 0.048 13.3 3.4 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-C2H2_4 PF13894.6 KII67068.1 - 0.98 10.4 8.5 1.9 9.6 2.3 3.5 3 1 0 3 3 3 0 C2H2-type zinc finger Cyclin_N PF00134.23 KII67069.1 - 3.2e-33 114.2 0.1 5.1e-33 113.5 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KII67069.1 - 2.9e-10 40.2 0.0 9.9e-10 38.5 0.0 1.9 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF3899 PF13038.6 KII67069.1 - 0.093 13.2 0.0 0.37 11.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) RT_RNaseH PF17917.1 KII67070.1 - 2.2e-07 31.1 0.0 4.8e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII67070.1 - 1.1e-06 28.5 0.0 3.2e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII67070.1 - 0.0098 16.1 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Viral_Beta_CD PF04530.12 KII67070.1 - 0.062 13.6 0.1 0.23 11.7 0.0 1.9 2 0 0 2 2 2 0 Viral Beta C/D like family Ribosomal_L6e PF01159.19 KII67070.1 - 0.078 13.5 0.1 0.15 12.6 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L6e Kelch_6 PF13964.6 KII67072.1 - 6.2e-19 67.6 8.5 2e-07 31.0 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII67072.1 - 1.3e-18 66.7 3.4 2e-06 27.7 0.1 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII67072.1 - 3.7e-18 65.3 8.1 6.7e-05 23.1 0.1 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII67072.1 - 4.6e-18 64.5 6.8 8.7e-06 25.2 1.2 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII67072.1 - 2.3e-16 59.4 14.2 6.8e-08 32.3 0.9 3.7 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 KII67072.1 - 3.3e-06 26.8 4.8 0.0064 16.4 0.5 3.2 3 0 0 3 3 3 2 Kelch motif ATR13 PF16829.5 KII67073.1 - 0.0063 16.9 0.0 0.012 16.0 0.0 1.6 1 1 0 1 1 1 1 Avirulence protein ATR13, RxLR effector PDH PF02153.17 KII67076.1 - 0.089 11.8 0.2 0.14 11.2 0.2 1.2 1 0 0 1 1 1 0 Prephenate dehydrogenase RVT_1 PF00078.27 KII67079.1 - 3.9e-08 33.1 0.0 6.3e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-UBR PF02207.20 KII67081.1 - 3.7e-14 52.7 14.4 3.7e-14 52.7 14.4 2.5 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) HARP PF07443.13 KII67081.1 - 0.061 13.0 0.2 1.6 8.4 0.1 2.5 2 0 0 2 2 2 0 HepA-related protein (HARP) Kelch_4 PF13418.6 KII67083.1 - 3.1e-20 71.9 18.4 2.1e-05 24.4 0.1 6.2 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 KII67083.1 - 1.1e-18 66.8 16.4 3.2e-05 24.1 0.2 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.25 KII67083.1 - 1.2e-15 56.8 15.3 5.5e-05 22.7 0.5 5.5 5 1 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII67083.1 - 3.5e-08 33.5 19.2 0.034 14.5 0.1 5.9 4 2 1 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII67083.1 - 0.00014 21.7 13.0 0.098 12.7 0.3 4.5 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 KII67083.1 - 0.001 18.9 15.1 0.85 9.7 0.1 5.4 5 1 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 KII67085.1 - 6.4e-16 58.0 8.0 1.7e-06 28.1 1.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII67085.1 - 1.5e-14 53.8 3.5 0.00016 21.8 0.2 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII67085.1 - 4.7e-14 51.7 6.0 3.4e-06 26.5 0.4 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII67085.1 - 2.1e-13 50.0 5.7 0.00041 20.3 0.2 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII67085.1 - 1.9e-06 27.7 6.4 0.0021 18.0 0.2 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KII67085.1 - 9.8e-05 22.2 8.7 0.0013 18.7 0.2 3.4 3 1 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 KII67086.1 - 2.7e-05 24.1 4.0 7.5e-05 22.7 0.1 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII67086.1 - 0.0008 18.9 2.2 0.14 11.8 0.1 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII67086.1 - 0.0063 16.8 2.1 0.028 14.7 0.1 2.5 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KII67086.1 - 0.024 14.9 1.7 0.11 12.8 0.1 2.4 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 KII67086.1 - 0.027 14.5 1.0 0.2 11.7 0.1 2.4 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 KII67087.1 - 1.2e-22 79.4 15.8 9.3e-06 25.8 0.3 5.4 4 1 1 5 5 5 5 Kelch motif Kelch_1 PF01344.25 KII67087.1 - 6.4e-18 64.1 11.3 2.8e-05 23.6 0.4 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII67087.1 - 1.5e-16 60.2 15.7 0.00026 21.2 0.3 5.7 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.6 KII67087.1 - 7e-11 42.0 24.8 0.00024 21.0 0.1 5.7 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII67087.1 - 3.7e-05 23.6 11.4 0.0079 16.2 0.5 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII67087.1 - 0.014 15.3 22.7 2.1 8.4 0.3 6.1 5 2 1 6 6 6 0 Kelch motif PQQ_3 PF13570.6 KII67087.1 - 0.022 15.3 1.8 6.9 7.3 0.2 3.6 3 0 0 3 3 3 0 PQQ-like domain DUF4857 PF16149.5 KII67088.1 - 0.082 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4857) Sortilin-Vps10 PF15902.5 KII67089.1 - 1e-07 31.1 3.5 1.6e-06 27.2 0.0 2.7 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII67089.1 - 0.0006 20.0 4.1 0.0006 20.0 4.1 4.0 4 0 0 4 4 4 2 Low-density lipoprotein receptor domain class A BNR PF02012.20 KII67089.1 - 0.02 14.8 5.8 3.6 8.0 0.2 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat DUF3942 PF13078.6 KII67090.1 - 0.005 17.1 0.1 0.014 15.7 0.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3942) ArfGap PF01412.18 KII67091.1 - 0.0034 17.4 1.0 0.013 15.6 0.2 2.3 1 1 0 2 2 2 1 Putative GTPase activating protein for Arf OSTMP1 PF09777.9 KII67091.1 - 0.042 13.2 10.2 0.058 12.8 8.8 1.9 2 0 0 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor EnY2 PF10163.9 KII67091.1 - 0.12 12.8 4.6 0.45 10.9 2.2 2.8 3 0 0 3 3 3 0 Transcription factor e(y)2 MIF4G_like_2 PF09090.11 KII67093.1 - 0.025 14.1 0.1 0.027 13.9 0.1 1.1 1 0 0 1 1 1 0 MIF4G like PI3K_P85_iSH2 PF16454.5 KII67093.1 - 0.043 13.4 0.3 0.057 13.0 0.3 1.1 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain BNR PF02012.20 KII67095.1 - 2.6e-07 29.6 2.2 0.22 11.7 0.1 4.0 3 0 0 3 3 3 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII67095.1 - 9.9e-06 24.6 0.4 2.3e-05 23.4 0.4 1.6 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Tsp45I PF06300.12 KII67097.1 - 0.11 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Tsp45I type II restriction enzyme rve PF00665.26 KII67098.1 - 4.6e-24 84.9 0.0 6.2e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII67098.1 - 7.9e-05 22.4 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67098.1 - 0.0087 16.1 10.6 0.0092 16.1 2.5 3.4 3 1 1 4 4 4 1 Integrase zinc binding domain Myosin_N PF02736.19 KII67099.1 - 0.043 13.6 0.0 0.074 12.9 0.0 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Agenet PF05641.12 KII67099.1 - 0.096 13.2 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Agenet domain Serpin PF00079.20 KII67102.1 - 1.4e-29 103.6 3.4 1.5e-29 103.4 3.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RVP PF00077.20 KII67103.1 - 0.011 16.0 0.0 0.031 14.6 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII67103.1 - 0.012 16.1 0.0 0.086 13.4 0.0 2.4 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease AT_hook PF02178.19 KII67106.1 - 3.3 7.9 9.5 0.22 11.5 1.4 2.7 2 0 0 2 2 2 0 AT hook motif DDE_1 PF03184.19 KII67108.1 - 0.0025 17.5 0.2 0.0031 17.2 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Herpes_UL33 PF03581.13 KII67109.1 - 0.04 14.3 0.0 0.16 12.3 0.0 2.1 1 0 0 1 1 1 0 Herpesvirus UL33-like protein Zip PF02535.22 KII67116.1 - 1.1e-54 186.0 14.2 1.5e-54 185.5 14.2 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter COX7B PF05392.11 KII67116.1 - 0.06 13.0 0.3 0.24 11.1 0.1 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB Bax1-I PF01027.20 KII67116.1 - 3.5 7.4 20.6 1.3 8.8 0.4 2.7 3 0 0 3 3 3 0 Inhibitor of apoptosis-promoting Bax1 PXA PF02194.15 KII67118.1 - 9.8e-18 64.8 1.2 2.8e-17 63.3 1.2 1.8 1 0 0 1 1 1 1 PXA domain PX PF00787.24 KII67118.1 - 7.1e-11 42.1 6.7 2.1e-10 40.6 6.7 1.8 1 0 0 1 1 1 1 PX domain SNARE_assoc PF09335.11 KII67119.1 - 6.3e-15 55.7 4.5 6.3e-15 55.7 4.5 1.8 2 0 0 2 2 2 1 SNARE associated Golgi protein PRIMA1 PF16101.5 KII67121.1 - 0.22 11.6 0.0 0.27 11.3 0.0 1.1 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Xpo1 PF08389.12 KII67122.1 - 0.005 16.9 0.0 0.011 15.7 0.0 1.6 1 1 1 2 2 2 1 Exportin 1-like protein P_proprotein PF01483.20 KII67123.1 - 0.16 12.0 0.4 0.48 10.5 0.0 2.0 2 1 1 3 3 3 0 Proprotein convertase P-domain HTH_32 PF13565.6 KII67124.1 - 0.077 13.6 0.0 0.12 13.0 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain RT_RNaseH_2 PF17919.1 KII67125.1 - 9.7e-36 121.8 0.0 2.3e-35 120.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67125.1 - 9.3e-33 112.7 0.0 2.1e-32 111.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67125.1 - 3.3e-22 79.1 0.0 8.6e-22 77.7 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII67125.1 - 6.1e-22 78.1 0.0 1.4e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67125.1 - 9.9e-16 57.6 0.2 2.3e-15 56.4 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII67125.1 - 0.0003 20.5 0.0 0.00077 19.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII67125.1 - 0.00049 20.3 0.2 0.0035 17.5 0.0 2.7 2 0 0 2 2 2 1 H2C2 zinc finger Retrotrans_gag PF03732.17 KII67125.1 - 0.0064 16.7 1.5 0.086 13.1 0.0 2.9 3 0 0 3 3 2 1 Retrotransposon gag protein GCV_T PF01571.21 KII67125.1 - 0.0074 15.7 0.0 0.12 11.7 0.0 2.4 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain zf-CCHC PF00098.23 KII67125.1 - 0.014 15.4 12.1 0.026 14.6 4.7 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII67125.1 - 0.075 12.8 11.0 0.97 9.2 1.1 2.7 2 0 0 2 2 2 0 Zinc knuckle RVT_2 PF07727.14 KII67125.1 - 0.11 12.1 0.1 5.8 6.5 0.0 2.3 1 1 1 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII67125.1 - 0.17 12.5 0.0 0.43 11.2 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Haemagg_act PF05860.13 KII67126.1 - 1.3e-31 109.0 5.6 1.3e-31 109.0 5.6 4.4 4 0 0 4 4 4 1 haemagglutination activity domain PDZ_1 PF12812.7 KII67126.1 - 0.12 12.4 0.3 1.5 8.9 0.0 3.1 3 0 0 3 3 3 0 PDZ-like domain UPF0016 PF01169.19 KII67127.1 - 7e-19 67.9 6.5 1e-18 67.4 6.5 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0016 FTR1 PF03239.14 KII67127.1 - 0.00033 19.9 0.8 0.00044 19.5 0.8 1.1 1 0 0 1 1 1 1 Iron permease FTR1 family DDE_Tnp_IS1595 PF12762.7 KII67128.1 - 0.026 14.6 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain RNase_T PF00929.24 KII67129.1 - 1.6e-24 87.3 0.1 1.8e-24 87.2 0.1 1.0 1 0 0 1 1 1 1 Exonuclease DUF723 PF05265.13 KII67129.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF723) DUF382 PF04037.13 KII67131.1 - 1e-54 184.0 1.2 1e-54 184.0 1.2 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 KII67131.1 - 1.3e-20 73.0 2.0 2.9e-20 71.8 2.0 1.6 1 0 0 1 1 1 1 PSP CTD_bind PF04818.13 KII67132.1 - 2.1e-05 25.2 0.5 2.1e-05 25.2 0.5 2.9 3 0 0 3 3 3 1 RNA polymerase II-binding domain. Lsr2 PF11774.8 KII67132.1 - 0.046 13.9 0.0 0.091 12.9 0.0 1.5 1 0 0 1 1 1 0 Lsr2 PgaPase_1 PF06162.12 KII67132.1 - 0.053 13.3 3.0 0.19 11.5 1.0 2.7 1 1 2 4 4 4 0 Putative pyroglutamyl peptidase PgaPase_1 Nrap_D5 PF17406.2 KII67132.1 - 0.31 10.8 2.6 0.79 9.5 2.6 1.8 1 1 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 Rap_GAP PF02145.15 KII67135.1 - 6.1e-35 120.5 0.0 1.6e-34 119.1 0.0 1.7 1 0 0 1 1 1 1 Rap/ran-GAP adh_short PF00106.25 KII67137.1 - 1.3e-13 50.9 0.1 9.8e-13 48.0 0.1 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII67137.1 - 4.2e-08 33.0 0.1 1.2e-07 31.5 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII67137.1 - 0.0029 17.6 0.0 0.0046 16.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Glyco_tran_WecB PF03808.13 KII67137.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family adh_short PF00106.25 KII67138.1 - 8.4e-17 61.3 0.0 4.1e-16 59.0 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII67138.1 - 0.0013 18.4 0.0 0.004 16.7 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 KII67138.1 - 0.014 14.8 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KII67138.1 - 0.015 14.5 0.1 0.024 13.8 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Ribosomal_L12 PF00542.19 KII67138.1 - 0.049 14.0 0.8 0.099 13.0 0.8 1.5 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain KR PF08659.10 KII67138.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 KR domain RNA_pol_Rpb4 PF03874.16 KII67139.1 - 0.0062 16.9 0.5 0.022 15.1 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb4 Utp12 PF04003.12 KII67139.1 - 0.016 15.5 1.3 0.077 13.3 0.1 2.4 2 1 0 2 2 2 0 Dip2/Utp12 Family AAA PF00004.29 KII67140.1 - 1.3e-13 51.5 0.0 2.5e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 KII67140.1 - 2.9e-12 46.8 0.1 9.5e-12 45.2 0.1 2.0 1 1 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 KII67140.1 - 1.3e-10 41.3 0.0 3.9e-10 39.8 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 KII67140.1 - 1.5e-06 28.5 0.2 1.9e-05 24.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 KII67140.1 - 1.2e-05 25.1 0.0 2.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KII67140.1 - 2.1e-05 24.3 0.0 3.6e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 KII67140.1 - 4e-05 23.6 0.0 0.00013 22.0 0.0 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 KII67140.1 - 9.7e-05 22.8 0.0 0.004 17.5 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_19 PF13245.6 KII67140.1 - 0.00013 22.3 0.0 0.00028 21.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 KII67140.1 - 0.0004 20.7 0.0 0.0014 18.9 0.0 1.9 2 0 0 2 2 1 1 AAA C-terminal domain AAA_5 PF07728.14 KII67140.1 - 0.0014 18.7 0.0 0.0038 17.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KII67140.1 - 0.0022 18.1 0.0 0.0043 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 KII67140.1 - 0.0027 17.5 2.1 0.035 13.9 0.0 3.1 2 2 2 4 4 4 1 DEAD/DEAH box helicase AAA_11 PF13086.6 KII67140.1 - 0.0041 16.9 0.0 0.0061 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KII67140.1 - 0.01 15.3 0.0 3.5 7.0 0.0 2.3 1 1 1 2 2 2 1 PhoH-like protein DUF2075 PF09848.9 KII67140.1 - 0.016 14.5 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 KII67140.1 - 0.021 14.2 0.1 0.14 11.5 0.1 2.3 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 KII67140.1 - 0.022 13.9 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 KII67140.1 - 0.036 13.6 0.0 0.07 12.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 KII67140.1 - 0.048 13.4 0.1 0.24 11.1 0.0 2.1 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 KII67140.1 - 0.054 13.0 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 KII67140.1 - 0.073 13.5 0.0 0.26 11.7 0.0 2.0 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 KII67140.1 - 0.08 12.7 0.0 0.23 11.2 0.0 1.9 1 1 0 1 1 1 0 IstB-like ATP binding protein ProQ_C PF17516.2 KII67140.1 - 0.12 11.8 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 ProQ C-terminal domain AAA_28 PF13521.6 KII67140.1 - 0.19 11.9 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Helicase_C PF00271.31 KII67144.1 - 9.4e-18 64.6 0.8 1.8e-15 57.2 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 KII67144.1 - 2.7e-16 59.8 0.0 7.3e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 KII67144.1 - 9.6e-16 58.3 6.1 9.6e-16 58.3 6.1 2.8 2 0 0 2 2 2 1 RecQ zinc-binding RQC PF09382.10 KII67144.1 - 1.6e-13 50.4 0.0 4.5e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 RQC domain ResIII PF04851.15 KII67144.1 - 5.5e-05 23.2 0.0 5.5e-05 23.2 0.0 3.0 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit HRDC PF00570.23 KII67144.1 - 0.00033 20.6 0.0 0.00076 19.4 0.0 1.6 1 0 0 1 1 1 1 HRDC domain YqzE PF14038.6 KII67144.1 - 0.11 12.5 0.4 0.39 10.7 0.4 1.9 1 0 0 1 1 1 0 YqzE-like protein Tn7_Tnp_TnsA_N PF08722.11 KII67144.1 - 0.42 10.8 3.5 0.63 10.3 0.0 2.8 3 0 0 3 3 3 0 TnsA endonuclease N terminal LZ3wCH PF18517.1 KII67144.1 - 0.75 9.9 6.7 10 6.3 0.1 4.1 4 0 0 4 4 4 0 Leucine zipper with capping helix domain DDE_3 PF13358.6 KII67146.1 - 3.7e-06 26.8 0.1 1.2e-05 25.1 0.1 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII67146.1 - 0.018 15.3 0.3 0.052 13.8 0.1 1.9 2 1 0 2 2 2 0 Transposase HTH_23 PF13384.6 KII67146.1 - 0.054 13.3 0.6 0.99 9.3 0.1 2.4 2 0 0 2 2 2 0 Homeodomain-like domain HSL_N PF06350.12 KII67147.1 - 1.2e-10 40.9 0.2 1.4e-10 40.6 0.2 1.0 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus MRP-S33 PF08293.11 KII67147.1 - 0.066 13.5 0.0 0.21 11.9 0.0 1.9 1 1 0 1 1 1 0 Mitochondrial ribosomal subunit S27 Abhydrolase_3 PF07859.13 KII67148.1 - 2.1e-38 132.3 0.0 7e-27 94.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold HSL_N PF06350.12 KII67148.1 - 2.3e-10 39.9 0.0 3.3e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus Say1_Mug180 PF10340.9 KII67148.1 - 7.8e-10 38.1 0.0 1.1e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase CUE PF02845.16 KII67151.1 - 0.00099 18.8 0.0 0.0029 17.3 0.0 1.7 1 0 0 1 1 1 1 CUE domain HSP20 PF00011.21 KII67152.1 - 1.4e-12 47.7 0.0 1.8e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Fis1_TPR_C PF14853.6 KII67153.1 - 3.3e-08 33.5 0.2 5.7e-08 32.7 0.2 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 KII67153.1 - 0.00044 20.1 1.2 0.00072 19.5 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KII67153.1 - 0.0007 20.2 0.2 0.0048 17.6 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KII67153.1 - 0.0047 16.7 0.1 0.01 15.6 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII67153.1 - 0.031 14.5 0.0 0.099 12.9 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Fis1_TPR_N PF14852.6 KII67153.1 - 0.033 13.9 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat TPR_9 PF13371.6 KII67153.1 - 0.12 12.5 0.3 1.1 9.5 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KII67153.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 ETRAMP PF09716.10 KII67153.1 - 0.13 12.3 0.0 0.18 11.9 0.0 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Syndecan PF01034.20 KII67153.1 - 0.17 11.8 0.3 1.3 9.0 0.0 2.1 2 0 0 2 2 2 0 Syndecan domain NatB_MDM20 PF09797.9 KII67154.1 - 0.00025 20.1 0.4 0.0012 17.9 0.0 2.3 3 0 0 3 3 3 1 N-acetyltransferase B complex (NatB) non catalytic subunit EMP70 PF02990.16 KII67155.1 - 1.6e-88 297.7 24.2 2.3e-88 297.1 24.2 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 MF_alpha PF04648.12 KII67155.1 - 0.086 13.1 1.0 0.18 12.1 1.0 1.6 1 0 0 1 1 1 0 Yeast mating factor alpha hormone LprI PF07007.12 KII67156.1 - 0.047 14.4 0.1 0.11 13.1 0.0 1.7 2 0 0 2 2 2 0 Lysozyme inhibitor LprI DUF148 PF02520.17 KII67157.1 - 0.22 11.6 4.4 3.8 7.7 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF148 UbiA PF01040.18 KII67158.1 - 2.1e-39 135.3 16.8 2.6e-39 135.0 16.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family YtpI PF14007.6 KII67158.1 - 0.013 15.6 1.6 0.048 13.8 1.6 2.0 1 0 0 1 1 1 0 YtpI-like protein Pkinase PF00069.25 KII67159.1 - 3.2e-44 151.3 1.2 6.5e-44 150.3 1.2 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII67159.1 - 4.6e-19 68.7 0.1 8.2e-19 67.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII67159.1 - 0.077 12.3 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 Kinase-like YrbL-PhoP_reg PF10707.9 KII67159.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL VASt PF16016.5 KII67161.1 - 6e-06 26.7 0.9 1.2e-05 25.8 0.9 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain HTH_Tnp_Tc3_2 PF01498.18 KII67162.1 - 1.7e-05 25.0 0.0 2.9e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Transposase PRP3 PF08572.10 KII67162.1 - 0.0022 17.8 1.3 0.0028 17.4 1.3 1.1 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF4541 PF15074.6 KII67162.1 - 0.11 13.2 0.9 0.21 12.2 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4541) JmjN PF02375.17 KII67162.1 - 0.19 11.7 0.0 0.56 10.2 0.0 1.8 1 0 0 1 1 1 0 jmjN domain Arm-DNA-bind_2 PF12167.8 KII67163.1 - 0.046 13.6 0.3 0.1 12.5 0.1 1.7 2 0 0 2 2 2 0 Arm DNA-binding domain FAD_binding_3 PF01494.19 KII67164.1 - 3.7e-18 65.9 0.0 6.5e-09 35.5 0.0 2.4 3 0 0 3 3 3 2 FAD binding domain SE PF08491.10 KII67164.1 - 0.00024 20.3 0.3 0.00059 19.0 0.1 1.7 2 0 0 2 2 2 1 Squalene epoxidase Lycopene_cycl PF05834.12 KII67164.1 - 0.0057 15.8 0.0 0.0078 15.3 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.14 KII67164.1 - 0.12 11.3 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase AA_permease_2 PF13520.6 KII67165.1 - 7e-47 160.2 55.2 8.6e-47 159.9 55.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII67165.1 - 3.8e-17 62.1 49.3 4.7e-17 61.7 49.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KII67166.1 - 2.2e-45 155.3 52.8 2.5e-45 155.1 52.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII67166.1 - 1.1e-16 60.5 45.7 1.4e-16 60.2 45.7 1.0 1 0 0 1 1 1 1 Amino acid permease zf-HC5HC2H_2 PF13832.6 KII67168.1 - 7.2e-05 22.9 3.1 8.5e-05 22.7 3.1 1.2 1 0 0 1 1 1 1 PHD-zinc-finger like domain C1_1 PF00130.22 KII67168.1 - 0.0004 20.2 6.6 0.00042 20.1 3.5 2.0 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H PF13771.6 KII67168.1 - 0.017 15.4 7.1 0.022 15.0 7.1 1.3 1 1 0 1 1 1 0 PHD-like zinc-binding domain FANCL_C PF11793.8 KII67168.1 - 0.085 13.0 8.0 0.12 12.6 8.0 1.3 1 0 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 KII67168.1 - 0.23 11.4 9.9 0.43 10.5 9.2 1.8 1 1 1 2 2 2 0 PHD-finger zf-RING_2 PF13639.6 KII67168.1 - 0.4 11.1 10.5 0.074 13.4 6.5 1.7 2 0 0 2 2 2 0 Ring finger domain Nore1-SARAH PF16517.5 KII67169.1 - 0.97 9.4 4.5 2 8.4 2.5 2.4 1 1 1 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Adaptin_N PF01602.20 KII67171.1 - 3e-124 415.5 20.9 4e-124 415.1 20.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KII67171.1 - 6.3e-46 156.4 2.2 6.3e-46 156.4 2.2 3.6 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KII67171.1 - 1.5e-11 44.5 0.2 4.1e-05 23.9 0.0 5.1 3 2 4 7 7 6 3 HEAT repeats HEAT PF02985.22 KII67171.1 - 8.6e-09 34.9 2.4 0.023 14.9 0.1 6.0 6 0 0 6 6 6 2 HEAT repeat AP4E_app_platf PF14807.6 KII67171.1 - 0.00022 21.5 0.0 0.00067 20.0 0.0 1.8 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform DNA_alkylation PF08713.11 KII67171.1 - 0.0017 18.1 0.1 0.005 16.6 0.0 1.8 2 0 0 2 2 2 1 DNA alkylation repair enzyme Arm PF00514.23 KII67171.1 - 0.0027 17.7 3.0 2.5 8.3 0.0 4.7 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KII67171.1 - 0.011 16.3 0.3 28 5.4 0.0 4.2 2 1 1 3 3 3 0 HEAT-like repeat CLASP_N PF12348.8 KII67171.1 - 0.036 13.6 5.2 0.81 9.2 0.0 4.1 3 1 0 4 4 4 0 CLASP N terminal B2-adapt-app_C PF09066.10 KII67171.1 - 0.056 13.5 0.1 0.2 11.7 0.1 2.0 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain RasGEF_N_2 PF14663.6 KII67171.1 - 0.43 11.0 2.1 6.7 7.2 0.1 3.7 2 1 2 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RTP1_C1 PF10363.9 KII67171.1 - 0.56 10.4 2.9 2.3 8.5 0.1 3.3 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 TM2 PF05154.16 KII67172.1 - 0.0012 19.1 4.1 0.0032 17.8 4.1 1.6 1 0 0 1 1 1 1 TM2 domain DUF4477 PF14780.6 KII67174.1 - 0.00029 20.5 3.0 0.28 10.8 0.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4477) G_glu_transpept PF01019.21 KII67176.1 - 3.2e-112 375.9 0.0 3.7e-66 223.9 0.0 2.7 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase LysM PF01476.20 KII67177.1 - 0.0028 17.7 0.0 0.0045 17.0 0.0 1.3 1 0 0 1 1 1 1 LysM domain Citrate_ly_lig PF08218.11 KII67177.1 - 0.067 12.9 0.0 0.079 12.6 0.0 1.1 1 0 0 1 1 1 0 Citrate lyase ligase C-terminal domain Exo_endo_phos PF03372.23 KII67178.1 - 0.00019 21.0 0.1 0.0005 19.6 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KII67178.1 - 0.083 12.7 0.2 0.28 11.0 0.2 2.0 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DUF460 PF04312.13 KII67178.1 - 0.096 12.4 0.0 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF460) RIBIOP_C PF04950.12 KII67179.1 - 5e-39 134.5 1.1 1.9e-27 96.5 0.2 2.0 1 1 1 2 2 2 2 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KII67180.1 - 4.9e-07 29.7 0.0 1.7e-06 28.0 0.0 2.0 1 0 0 1 1 1 1 AARP2CN (NUC121) domain HU-CCDC81_bac_1 PF18174.1 KII67180.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 1 HTH_Tnp_Tc3_2 PF01498.18 KII67181.1 - 0.00078 19.6 0.0 0.0035 17.6 0.0 2.0 2 1 0 2 2 2 1 Transposase HTH_23 PF13384.6 KII67181.1 - 0.027 14.3 0.1 0.61 10.0 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain HTH_21 PF13276.6 KII67181.1 - 0.055 13.6 0.0 9.8 6.4 0.0 2.4 2 0 0 2 2 2 0 HTH-like domain HTH_32 PF13565.6 KII67181.1 - 0.1 13.2 0.0 0.22 12.1 0.0 1.6 2 0 0 2 2 2 0 Homeodomain-like domain HTH_29 PF13551.6 KII67181.1 - 0.14 12.2 0.4 5.3 7.2 0.0 2.8 3 0 0 3 3 3 0 Winged helix-turn helix Abhydrolase_1 PF00561.20 KII67182.1 - 1.4e-11 44.6 0.0 5.2e-11 42.7 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KII67182.1 - 4.7e-07 29.3 0.0 0.0019 17.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 KII67182.1 - 0.0044 16.6 0.1 0.0069 16.0 0.1 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_4 PF08386.10 KII67182.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein FSH1 PF03959.13 KII67182.1 - 0.14 11.8 0.1 0.88 9.2 0.1 2.1 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Abhydro_lipase PF04083.16 KII67183.1 - 9.8e-09 34.7 0.0 2.3e-08 33.5 0.0 1.5 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region DUF4566 PF15130.6 KII67184.1 - 0.1 12.0 0.2 13 5.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4566) NCE101 PF11654.8 KII67184.1 - 0.72 9.6 3.6 22 4.9 0.3 2.5 2 0 0 2 2 2 0 Non-classical export protein 1 NUDIX PF00293.28 KII67185.1 - 2.9e-10 40.3 0.0 4.2e-10 39.8 0.0 1.3 1 1 0 1 1 1 1 NUDIX domain SCO1-SenC PF02630.14 KII67187.1 - 8e-11 42.0 0.0 1.1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC IU_nuc_hydro PF01156.19 KII67188.1 - 2.4e-46 158.7 0.0 2.8e-46 158.5 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase IU_nuc_hydro PF01156.19 KII67189.1 - 3.3e-21 76.2 0.0 3.7e-21 76.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase ETC_C1_NDUFA4 PF04800.12 KII67190.1 - 5.2e-30 103.5 1.0 7.1e-30 103.1 1.0 1.1 1 0 0 1 1 1 1 ETC complex I subunit conserved region Guanylate_kin PF00625.21 KII67191.1 - 1.3e-05 25.0 0.0 1.9e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Guanylate kinase Kelch_6 PF13964.6 KII67192.1 - 3.5e-09 36.6 4.0 0.0039 17.4 0.0 4.6 2 2 2 4 4 4 3 Kelch motif Kelch_2 PF07646.15 KII67192.1 - 7.5e-06 25.7 1.0 1.8 8.6 0.0 3.7 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KII67192.1 - 8.4e-05 22.1 1.3 0.39 10.3 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII67192.1 - 0.062 13.3 4.6 1.4 9.0 0.0 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 KII67192.1 - 0.28 11.2 7.0 1.1 9.4 0.0 3.1 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 KII67193.1 - 1e-13 51.0 2.4 1.8e-05 24.8 0.2 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII67193.1 - 2.9e-12 46.4 0.2 6.2e-05 22.9 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII67193.1 - 9.7e-12 44.3 2.8 0.00017 21.1 0.0 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 KII67193.1 - 1.2e-11 44.3 6.3 5e-08 32.7 0.0 3.3 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 KII67193.1 - 2.1e-05 24.7 0.0 0.25 11.7 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII67193.1 - 0.00018 21.4 2.0 0.08 13.0 0.1 3.0 3 0 0 3 3 3 2 Kelch motif MULE PF10551.9 KII67194.1 - 7.2e-15 55.2 0.0 1.4e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain Kelch_5 PF13854.6 KII67195.1 - 2.4e-11 43.3 12.1 4.8e-07 29.6 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 KII67195.1 - 1.4e-06 28.4 21.6 0.033 14.5 0.1 6.6 5 2 1 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII67195.1 - 1.4e-06 28.4 8.0 0.33 11.3 0.4 6.8 6 1 0 6 6 6 1 Galactose oxidase, central domain Kelch_4 PF13418.6 KII67195.1 - 0.00056 19.9 0.0 0.00056 19.9 0.0 6.5 7 1 1 8 8 8 1 Galactose oxidase, central domain Kelch_2 PF07646.15 KII67195.1 - 0.0079 16.1 18.6 0.87 9.7 0.2 6.9 6 3 1 7 7 7 2 Kelch motif Kelch_1 PF01344.25 KII67195.1 - 0.014 15.0 18.5 0.039 13.6 0.1 6.5 7 0 0 7 7 7 0 Kelch motif Kelch_1 PF01344.25 KII67196.1 - 1.4e-15 56.5 15.3 0.00021 20.8 1.7 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 KII67196.1 - 6.1e-14 51.8 6.4 5.6e-05 23.1 0.4 4.8 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KII67196.1 - 9.7e-14 51.1 6.9 0.00019 21.6 0.0 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_5 PF13854.6 KII67196.1 - 5.8e-11 42.1 9.0 7.1e-05 22.7 0.7 4.7 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 KII67196.1 - 9.1e-09 35.0 9.4 0.021 14.8 0.5 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII67196.1 - 1.2e-06 28.7 4.9 0.16 12.3 0.0 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain RT_RNaseH_2 PF17919.1 KII67197.1 - 5.2e-07 29.6 0.0 1.3e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67197.1 - 0.018 14.5 0.1 0.8 9.2 0.0 2.5 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Catalase-rel PF06628.12 KII67197.1 - 0.041 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 Catalase-related immune-responsive Integrin_beta PF00362.18 KII67199.1 - 4.5e-19 69.1 0.0 7.7e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain I-EGF_1 PF18372.1 KII67199.1 - 8.9e-07 28.9 4.4 8.9e-07 28.9 4.4 3.2 3 0 0 3 3 3 1 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 KII67199.1 - 0.0078 16.6 12.1 0.0078 16.6 12.1 2.8 1 1 1 2 2 2 1 EGF-like domain Septin PF00735.18 KII67202.1 - 6.5e-93 311.1 0.0 1.1e-92 310.4 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KII67202.1 - 1.8e-07 31.2 0.0 1.7e-06 28.1 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KII67202.1 - 0.00061 19.9 0.4 0.45 10.5 0.0 3.3 3 0 0 3 3 3 1 Dynamin family GTP_EFTU PF00009.27 KII67202.1 - 0.0033 17.0 0.2 0.19 11.2 0.0 2.7 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_32 PF13654.6 KII67202.1 - 0.0064 15.3 2.7 0.81 8.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 KII67202.1 - 0.013 15.4 1.5 0.25 11.2 0.0 2.9 3 1 0 3 3 3 0 RsgA GTPase AAA_22 PF13401.6 KII67202.1 - 0.018 15.3 0.0 0.15 12.3 0.0 2.4 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 KII67202.1 - 0.026 13.9 0.0 0.058 12.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family FeoB_N PF02421.18 KII67202.1 - 0.095 12.2 0.6 0.71 9.4 0.1 2.6 2 1 0 2 2 2 0 Ferrous iron transport protein B YlbE PF14003.6 KII67202.1 - 0.14 12.7 3.2 0.18 12.3 1.5 2.1 2 0 0 2 2 2 0 YlbE-like protein ThiF PF00899.21 KII67204.1 - 1e-07 31.6 0.0 7.8e-05 22.1 0.0 2.4 2 1 0 2 2 2 2 ThiF family ING PF12998.7 KII67205.1 - 0.0065 17.0 1.2 0.016 15.8 1.2 1.6 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Pkinase PF00069.25 KII67206.1 - 3.5e-59 200.3 0.0 8.6e-59 199.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII67206.1 - 1.4e-30 106.4 0.2 2.3e-22 79.5 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 KII67206.1 - 0.00013 21.1 0.1 0.00019 20.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KII67206.1 - 0.0012 18.8 0.1 0.24 11.3 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KII67206.1 - 0.0082 15.2 0.0 0.023 13.8 0.0 1.7 2 0 0 2 2 2 1 Seadornavirus VP7 Kinase-like PF14531.6 KII67206.1 - 0.012 14.9 0.1 0.11 11.8 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 KII67206.1 - 0.022 14.1 0.2 0.061 12.7 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Imm30 PF15565.6 KII67209.1 - 0.066 13.3 0.1 0.095 12.8 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 30 SF1-HH PF16275.5 KII67211.1 - 1.3e-36 125.4 0.2 2.7e-36 124.3 0.2 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 KII67211.1 - 4.2e-07 29.7 0.1 1.1e-06 28.3 0.1 1.8 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 KII67211.1 - 0.0042 17.1 10.6 0.099 12.8 0.6 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 KII67211.1 - 0.0046 16.9 6.8 0.57 10.2 2.8 2.5 1 1 1 2 2 2 2 Zinc knuckle Rhodanese_C PF12368.8 KII67211.1 - 0.18 12.2 2.1 0.32 11.4 2.1 1.4 1 0 0 1 1 1 0 Rhodanase C-terminal PolC_DP2 PF03833.13 KII67211.1 - 0.25 9.2 0.4 0.37 8.6 0.4 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Histone_HNS PF00816.21 KII67211.1 - 0.32 11.9 2.7 7.9 7.4 0.9 2.4 2 0 0 2 2 2 0 H-NS histone family TF_Zn_Ribbon PF08271.12 KII67211.1 - 0.43 10.1 3.0 1.1 8.8 3.0 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding PHD_4 PF16866.5 KII67211.1 - 0.78 9.9 4.5 1.6 8.9 4.5 1.5 1 0 0 1 1 1 0 PHD-finger zf-CCHC_6 PF15288.6 KII67211.1 - 1 9.3 4.7 5 7.1 0.1 2.8 2 0 0 2 2 2 0 Zinc knuckle CDC45 PF02724.14 KII67211.1 - 1.8 6.8 4.0 2.2 6.5 4.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2672 PF10878.8 KII67213.1 - 0.12 12.4 0.2 0.21 11.6 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2672) DDE_Tnp_IS1595 PF12762.7 KII67214.1 - 4.6e-05 23.5 0.2 0.00027 21.0 0.0 2.1 1 1 1 2 2 2 1 ISXO2-like transposase domain MRP-63 PF14978.6 KII67214.1 - 0.053 14.1 0.0 0.087 13.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome protein 63 SurA_N_3 PF13624.6 KII67214.1 - 0.056 13.2 0.0 0.086 12.6 0.0 1.3 1 0 0 1 1 1 0 SurA N-terminal domain DDE_3 PF13358.6 KII67216.1 - 5.3e-08 32.7 0.0 5.9e-08 32.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease But2 PF09792.9 KII67216.1 - 0.15 12.5 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin 3 binding protein But2 C-terminal domain OAF PF14941.6 KII67218.1 - 0.12 11.7 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Transcriptional regulator, Out at first RabGAP-TBC PF00566.18 KII67220.1 - 6.5e-47 160.0 5.9 1.2e-46 159.1 5.9 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SNF2_N PF00176.23 KII67222.1 - 1.2e-74 251.1 0.1 3.2e-74 249.8 0.1 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 KII67222.1 - 8.3e-36 122.5 0.8 8.3e-36 122.5 0.8 3.2 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 KII67222.1 - 1.2e-28 100.1 1.9 1.2e-28 100.1 1.9 5.0 6 1 0 6 6 5 1 HAND Helicase_C PF00271.31 KII67222.1 - 1.1e-18 67.6 0.0 1.5e-17 63.9 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII67222.1 - 2.9e-09 37.1 0.0 2.9e-09 37.1 0.0 3.0 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KII67222.1 - 1.6e-07 31.3 0.0 1.6e-06 28.0 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF1086 PF06461.11 KII67222.1 - 1.1e-05 25.4 0.6 3.3e-05 23.7 0.6 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) DUF896 PF05979.12 KII67222.1 - 0.00052 19.8 2.2 0.0059 16.5 0.5 3.2 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF896) Mst1_SARAH PF11629.8 KII67222.1 - 0.0054 16.8 0.2 0.032 14.3 0.2 2.4 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 Myb_DNA-binding PF00249.31 KII67222.1 - 0.052 13.7 0.1 1.5 9.1 0.0 3.3 3 0 0 3 3 3 0 Myb-like DNA-binding domain DUF1456 PF07308.13 KII67222.1 - 0.1 12.9 0.4 0.54 10.6 0.4 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) DDE_1 PF03184.19 KII67224.1 - 0.00033 20.3 0.0 0.00046 19.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Roc PF08477.13 KII67224.1 - 0.04 14.1 0.0 0.063 13.5 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DDE_3 PF13358.6 KII67225.1 - 1.9e-28 99.1 0.0 3.5e-28 98.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII67225.1 - 1.2e-09 38.6 0.0 4.1e-07 30.5 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 KII67225.1 - 9.5e-08 31.6 0.0 1.4e-06 27.9 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain TrmB PF01978.19 KII67225.1 - 0.0055 16.6 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.6 KII67225.1 - 0.0061 16.7 0.1 0.016 15.3 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.18 KII67225.1 - 0.0063 16.4 0.2 0.013 15.4 0.2 1.5 1 0 0 1 1 1 1 'Paired box' domain HTH_40 PF14493.6 KII67225.1 - 0.011 16.1 0.1 0.1 13.0 0.1 2.5 2 1 1 3 3 3 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII67225.1 - 0.03 14.6 0.1 0.27 11.5 0.0 2.4 2 0 0 2 2 2 0 Transposase DDE_Tnp_ISAZ013 PF07592.11 KII67225.1 - 0.035 13.1 0.1 5.7 5.8 0.0 2.5 3 0 0 3 3 3 0 Rhodopirellula transposase DDE domain HTH_33 PF13592.6 KII67225.1 - 0.043 13.5 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 KII67225.1 - 0.05 13.0 0.0 0.12 11.8 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 UDPGT PF00201.18 KII67225.1 - 0.063 12.1 0.0 0.13 11.0 0.0 1.5 2 0 0 2 2 2 0 UDP-glucoronosyl and UDP-glucosyl transferase Ntox50 PF15542.6 KII67225.1 - 0.094 13.5 5.2 22 5.9 4.6 3.2 1 1 1 2 2 2 0 Bacterial toxin 50 HTH_Tnp_1 PF01527.20 KII67225.1 - 0.11 12.9 0.5 0.35 11.2 0.1 2.0 2 0 0 2 2 2 0 Transposase HTH_29 PF13551.6 KII67225.1 - 0.13 12.3 0.1 0.7 10.0 0.1 2.3 2 0 0 2 2 2 0 Winged helix-turn helix IMD PF08397.11 KII67225.1 - 0.16 11.3 0.0 1.7 8.0 0.1 2.1 2 0 0 2 2 2 0 IRSp53/MIM homology domain Dynamin_N PF00350.23 KII67226.1 - 1.7e-51 174.6 2.3 4.8e-51 173.1 0.1 2.5 3 0 0 3 3 3 1 Dynamin family Dynamin_M PF01031.20 KII67226.1 - 2.3e-49 168.1 12.1 9.9e-47 159.5 9.8 2.8 2 1 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 KII67226.1 - 9.2e-05 22.5 0.1 0.00046 20.2 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KII67226.1 - 0.025 15.0 0.0 0.093 13.1 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 KII67226.1 - 0.055 13.7 0.0 0.2 11.9 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 KII67226.1 - 0.055 14.0 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 PH domain GED PF02212.18 KII67227.1 - 0.012 15.7 0.8 0.024 14.8 0.8 1.5 1 0 0 1 1 1 0 Dynamin GTPase effector domain NRDE-2 PF08424.10 KII67228.1 - 7.3e-58 196.2 0.1 1.1e-57 195.6 0.1 1.3 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference MULE PF10551.9 KII67229.1 - 1.7e-08 34.7 0.0 4.9e-08 33.3 0.0 1.8 1 1 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.16 KII67229.1 - 2.2e-08 34.1 0.2 4.5e-08 33.1 0.2 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain DDE_3 PF13358.6 KII67230.1 - 1.8e-05 24.5 0.0 2.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease SURF1 PF02104.15 KII67231.1 - 1e-18 68.2 0.0 1.3e-18 67.8 0.0 1.1 1 0 0 1 1 1 1 SURF1 family EAV_GP5 PF15981.5 KII67231.1 - 0.065 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Envelope glycoprotein GP 5 of equine arteritis virus HTH_24 PF13412.6 KII67232.1 - 0.11 12.1 1.6 2 8.0 0.1 2.5 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding NuA4 PF09340.10 KII67233.1 - 0.0041 17.0 0.5 0.0081 16.0 0.5 1.5 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 AGO_N PF18236.1 KII67233.1 - 0.039 14.2 0.8 1.2 9.3 0.1 2.0 1 1 1 2 2 2 0 Argonaute N domain SMC_N PF02463.19 KII67235.1 - 4e-27 95.1 2.6 7.4e-27 94.2 2.6 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KII67235.1 - 2.6e-25 89.0 0.0 7.3e-25 87.6 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain T3SS_needle_F PF09392.10 KII67235.1 - 0.07 13.3 1.1 0.35 11.1 0.3 2.7 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF SbcCD_C PF13558.6 KII67235.1 - 0.095 12.9 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit COG2 PF06148.11 KII67235.1 - 0.12 12.5 13.2 0.89 9.6 1.3 4.2 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Peptidase_M57 PF12388.8 KII67235.1 - 0.47 10.0 3.7 0.24 11.0 0.2 2.1 2 0 0 2 2 2 0 Dual-action HEIGH metallo-peptidase Nup54 PF13874.6 KII67235.1 - 1.5 8.9 19.5 1.4 9.0 1.8 4.0 3 0 0 3 3 3 0 Nucleoporin complex subunit 54 SMC_N PF02463.19 KII67236.1 - 4.9e-05 22.9 14.5 0.00028 20.4 13.9 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DDE_3 PF13358.6 KII67237.1 - 3.2e-14 52.9 0.0 4.1e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Transposase_1 PF01359.18 KII67237.1 - 0.01 15.6 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Transposase (partial DDE domain) PT PF04886.12 KII67240.1 - 0.2 11.2 2.7 0.37 10.4 2.7 1.5 1 0 0 1 1 1 0 PT repeat DDE_Tnp_IS1595 PF12762.7 KII67241.1 - 0.00044 20.3 0.1 0.00065 19.7 0.1 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain Ran_BP1 PF00638.18 KII67242.1 - 3.5e-41 140.3 1.7 5.5e-41 139.7 1.7 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 KII67242.1 - 0.0036 17.2 0.2 0.0067 16.4 0.2 1.4 1 1 0 1 1 1 1 WH1 domain UPF0240 PF06784.11 KII67242.1 - 0.01 15.9 1.8 0.01 15.9 1.8 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0240) Endosulfine PF04667.17 KII67242.1 - 0.029 14.5 0.2 0.064 13.4 0.2 1.5 1 0 0 1 1 1 0 cAMP-regulated phosphoprotein/endosulfine conserved region VID27_PH PF17747.1 KII67242.1 - 0.034 14.4 0.0 0.051 13.9 0.0 1.3 1 0 0 1 1 1 0 VID27 PH-like domain RRM_1 PF00076.22 KII67243.1 - 7.1e-05 22.6 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Integrase_H2C2 PF17921.1 KII67245.1 - 4.3e-11 42.8 0.6 7.5e-11 42.0 0.6 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain RRF_GI PF12614.8 KII67245.1 - 0.012 15.8 0.2 5.3 7.2 0.0 2.5 3 0 0 3 3 3 0 Ribosome recycling factor DUF5093 PF17011.5 KII67250.1 - 0.17 12.1 4.3 0.19 12.0 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) Kelch_6 PF13964.6 KII67251.1 - 9.3e-28 95.6 14.9 4.2e-07 30.0 0.1 6.2 5 1 1 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KII67251.1 - 1.1e-22 79.8 2.5 6.2e-06 26.4 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII67251.1 - 2.4e-22 78.2 10.2 6.1e-06 25.7 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII67251.1 - 7.4e-21 73.9 11.8 8.7e-05 22.5 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KII67251.1 - 5.6e-15 54.9 14.4 0.00053 19.9 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KII67251.1 - 6.9e-12 44.9 11.5 0.035 14.1 0.1 5.7 6 0 0 6 6 6 3 Kelch motif FAM176 PF14851.6 KII67253.1 - 0.007 16.0 6.9 0.0075 15.9 0.3 2.6 2 1 1 3 3 3 1 FAM176 family ORC6 PF05460.13 KII67253.1 - 0.1 11.8 8.3 0.13 11.5 8.3 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) LAP1C PF05609.12 KII67253.1 - 2.9 6.9 11.7 3.6 6.6 11.7 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RVT_1 PF00078.27 KII67254.1 - 0.00039 20.0 0.1 0.18 11.3 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) AalphaY_MDB PF04611.12 KII67254.1 - 0.17 11.9 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region Ldl_recept_a PF00057.18 KII67255.1 - 1.4e-06 28.4 27.8 2e-06 27.9 10.4 3.3 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A SNAP PF14938.6 KII67256.1 - 0.0026 17.2 0.2 0.0042 16.6 0.2 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP CUTL PF16557.5 KII67256.1 - 0.12 12.6 0.6 0.21 11.8 0.6 1.4 1 0 0 1 1 1 0 CUT1-like DNA-binding domain of SATB Integrase_H2C2 PF17921.1 KII67258.1 - 2e-07 31.0 8.1 0.00011 22.2 6.8 2.7 1 1 1 2 2 2 2 Integrase zinc binding domain Spermine_synth PF01564.17 KII67259.1 - 2.7e-46 157.3 0.0 3.6e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KII67259.1 - 7e-13 48.3 0.0 1.5e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KII67259.1 - 0.003 18.2 0.0 0.006 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KII67259.1 - 0.0052 16.6 0.0 0.013 15.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain DUF5099 PF17025.5 KII67259.1 - 0.094 13.1 2.0 1.6 9.2 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5099) HTH_23 PF13384.6 KII67260.1 - 4e-07 29.6 0.0 9.1e-07 28.5 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 KII67260.1 - 1e-06 28.7 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 KII67260.1 - 2.8e-06 27.3 0.0 5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 KII67260.1 - 3e-06 26.9 0.0 0.0002 21.1 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII67260.1 - 0.00099 19.0 0.1 0.0012 18.8 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_11 PF08279.12 KII67260.1 - 0.0097 15.8 0.2 0.018 15.0 0.2 1.4 1 0 0 1 1 1 1 HTH domain HTH_Tnp_IS630 PF01710.16 KII67260.1 - 0.01 15.8 0.2 0.012 15.7 0.2 1.2 1 0 0 1 1 1 0 Transposase HTH_Crp_2 PF13545.6 KII67260.1 - 0.013 15.4 0.1 0.03 14.3 0.0 1.6 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain HTH_32 PF13565.6 KII67260.1 - 0.013 16.0 0.0 0.055 14.1 0.0 1.8 1 1 1 2 2 2 0 Homeodomain-like domain HTH_7 PF02796.15 KII67260.1 - 0.017 15.1 1.3 0.075 13.1 0.1 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase Sigma70_r4 PF04545.16 KII67260.1 - 0.05 13.1 0.0 0.35 10.4 0.0 2.2 3 0 0 3 3 3 0 Sigma-70, region 4 TrmB PF01978.19 KII67260.1 - 0.053 13.4 0.1 0.09 12.7 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 KII67260.1 - 0.12 12.3 0.1 0.53 10.3 0.1 2.0 1 1 0 1 1 1 0 MarR family Helicase_RecD PF05127.14 KII67260.1 - 0.12 12.2 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Helicase Sigma70_r4_2 PF08281.12 KII67260.1 - 0.15 11.7 0.1 0.6 9.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 DDE_3 PF13358.6 KII67261.1 - 1.5e-18 67.0 0.1 2.6e-18 66.2 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_24 PF13412.6 KII67261.1 - 1.9e-07 30.5 0.6 0.00014 21.4 0.0 2.3 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding PAX PF00292.18 KII67261.1 - 5.4e-07 29.6 0.0 8.9e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 KII67261.1 - 7.9e-07 28.7 0.0 4.2e-06 26.4 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain MarR_2 PF12802.7 KII67261.1 - 1.7e-05 24.6 0.0 3.8e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 KII67261.1 - 5.5e-05 23.0 0.0 0.00017 21.4 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_38 PF13936.6 KII67261.1 - 6.8e-05 22.5 0.4 0.0011 18.7 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.13 KII67261.1 - 0.00019 21.0 0.0 0.00041 19.9 0.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Sigma70_r4 PF04545.16 KII67261.1 - 0.00035 20.0 0.0 0.00098 18.6 0.0 1.7 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_28 PF13518.6 KII67261.1 - 0.00084 19.4 0.0 0.0035 17.4 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain Fe_dep_repress PF01325.19 KII67261.1 - 0.00084 19.5 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_IclR PF09339.10 KII67261.1 - 0.00084 19.1 0.0 0.0038 17.0 0.0 2.0 2 0 0 2 2 2 1 IclR helix-turn-helix domain Phage_CI_repr PF07022.13 KII67261.1 - 0.0013 18.7 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain HTH_29 PF13551.6 KII67261.1 - 0.0014 18.6 0.0 0.005 16.8 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.6 KII67261.1 - 0.0016 19.0 0.0 0.0092 16.6 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 KII67261.1 - 0.0021 17.4 0.1 0.0078 15.6 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 CRIC_ras_sig PF10534.9 KII67261.1 - 0.0069 16.5 0.0 0.021 15.0 0.0 1.8 1 0 0 1 1 1 1 Connector enhancer of kinase suppressor of ras HTH_Crp_2 PF13545.6 KII67261.1 - 0.015 15.3 0.1 0.033 14.2 0.1 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_27 PF13463.6 KII67261.1 - 0.019 15.4 0.1 0.053 14.0 0.0 1.8 2 0 0 2 2 1 0 Winged helix DNA-binding domain Sigma70_r4_2 PF08281.12 KII67261.1 - 0.043 13.5 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_40 PF14493.6 KII67261.1 - 0.065 13.7 0.1 0.13 12.8 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain LacI PF00356.21 KII67261.1 - 0.069 13.0 0.2 0.25 11.2 0.1 2.0 2 1 0 2 2 2 0 Bacterial regulatory proteins, lacI family HTH_50 PF18024.1 KII67261.1 - 0.091 12.4 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.22 KII67261.1 - 0.093 12.8 0.1 0.22 11.6 0.0 1.7 2 0 0 2 2 1 0 Helix-turn-helix MarR PF01047.22 KII67261.1 - 0.11 12.4 0.2 0.35 10.8 0.0 1.9 2 0 0 2 2 1 0 MarR family GrpE PF01025.19 KII67262.1 - 2.9e-34 118.1 0.2 3.8e-34 117.8 0.2 1.1 1 0 0 1 1 1 1 GrpE Microvir_H PF04687.12 KII67262.1 - 0.0054 16.1 0.1 0.0071 15.8 0.1 1.2 1 0 0 1 1 1 1 Microvirus H protein (pilot protein) ASD2 PF08687.11 KII67262.1 - 0.0059 16.2 1.2 0.0082 15.7 1.2 1.1 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 TMF_DNA_bd PF12329.8 KII67262.1 - 0.0063 16.5 3.6 0.0098 15.9 3.6 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 KII67262.1 - 0.049 13.4 0.9 0.087 12.6 0.4 1.7 1 1 0 1 1 1 0 Septum formation initiator PIN_10 PF18478.1 KII67262.1 - 0.14 12.4 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 PIN like domain SlyX PF04102.12 KII67262.1 - 0.25 12.0 0.3 0.25 12.0 0.3 1.9 2 0 0 2 2 2 0 SlyX EXS PF03124.14 KII67263.1 - 2.9e-24 86.0 14.8 5.7e-24 85.1 14.8 1.4 1 0 0 1 1 1 1 EXS family SPX PF03105.19 KII67263.1 - 5.1e-15 56.3 10.4 1.1e-09 38.8 8.7 2.1 1 1 0 2 2 2 2 SPX domain CPSase_L_D3 PF02787.19 KII67263.1 - 0.03 14.7 0.2 0.052 13.9 0.2 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain PFEMP PF03011.15 KII67264.1 - 0.6 10.8 5.0 0.25 12.0 1.8 1.8 1 1 1 2 2 2 0 PFEMP DBL domain Macoilin PF09726.9 KII67264.1 - 2.6 6.5 14.8 3 6.3 14.8 1.0 1 0 0 1 1 1 0 Macoilin family TMEM156 PF15106.6 KII67265.1 - 0.037 13.5 2.6 0.077 12.4 2.6 1.5 1 0 0 1 1 1 0 TMEM156 protein family MGC-24 PF05283.11 KII67266.1 - 0.16 12.5 7.4 0.31 11.5 7.4 1.6 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin KCH PF16944.5 KII67270.1 - 0.0057 16.5 0.2 0.0075 16.1 0.2 1.2 1 0 0 1 1 1 1 Fungal potassium channel DUF1180 PF06679.12 KII67270.1 - 0.074 13.5 0.5 0.088 13.2 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Nucleoside_tran PF01733.18 KII67271.1 - 0.00054 19.4 10.1 0.053 12.9 0.4 3.4 2 1 0 3 3 3 2 Nucleoside transporter ECSCR PF15820.5 KII67271.1 - 0.0037 17.0 0.2 0.41 10.5 0.0 3.3 3 0 0 3 3 3 1 Endothelial cell-specific chemotaxis regulator FtsX PF02687.21 KII67271.1 - 0.0044 17.5 1.0 12 6.4 0.1 3.3 3 0 0 3 3 3 0 FtsX-like permease family EamA PF00892.20 KII67271.1 - 0.0075 16.4 1.5 4.4 7.5 0.0 3.3 3 0 0 3 3 3 1 EamA-like transporter family EphA2_TM PF14575.6 KII67271.1 - 0.013 16.3 0.2 29 5.6 0.0 3.5 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain TRP PF06011.12 KII67271.1 - 0.049 12.4 5.9 0.16 10.7 1.7 2.6 2 1 0 2 2 2 0 Transient receptor potential (TRP) ion channel YIF1 PF03878.15 KII67271.1 - 0.063 12.8 3.6 3.5 7.1 0.3 2.9 3 0 0 3 3 3 0 YIF1 DUF979 PF06166.12 KII67271.1 - 0.087 12.0 2.4 0.97 8.5 0.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF979) Caroten_synth PF04240.12 KII67271.1 - 0.092 12.6 0.1 12 5.6 0.0 2.6 3 0 0 3 3 3 0 Carotenoid biosynthesis protein Amnionless PF14828.6 KII67271.1 - 0.11 11.3 3.2 2.6 6.8 0.0 2.9 1 1 1 3 3 3 0 Amnionless DUF5305 PF17231.2 KII67271.1 - 0.14 11.6 10.1 5.8 6.2 0.3 3.6 2 1 1 3 3 3 0 Family of unknown function (DUF5305) DUF4834 PF16118.5 KII67271.1 - 0.17 12.9 6.5 0.47 11.4 0.2 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) JTB PF05439.12 KII67271.1 - 0.17 11.9 1.7 24 5.0 0.0 3.2 3 0 0 3 3 3 0 Jumping translocation breakpoint protein (JTB) DUF2304 PF10066.9 KII67271.1 - 0.2 11.9 4.3 19 5.5 0.1 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) DUF3397 PF11877.8 KII67271.1 - 0.29 11.4 3.4 0.98 9.6 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3397) NS3_envE PF02723.14 KII67271.1 - 0.48 10.5 3.1 14 5.9 0.0 3.2 3 0 0 3 3 3 0 Non-structural protein NS3/Small envelope protein E RAMP4 PF06624.12 KII67271.1 - 1.5 8.9 5.4 3.9 7.6 0.0 4.0 3 1 1 4 4 4 0 Ribosome associated membrane protein RAMP4 FeoB_associated PF12669.7 KII67271.1 - 1.5 9.3 8.5 10 6.6 0.6 3.1 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein LicD PF04991.13 KII67271.1 - 7 6.7 8.3 1.3 9.1 2.9 2.4 2 1 1 3 3 3 0 LicD family MGC-24 PF05283.11 KII67272.1 - 0.072 13.5 1.7 0.094 13.2 1.7 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin CHD5 PF04420.14 KII67274.1 - 0.054 13.4 0.6 0.11 12.4 0.4 1.7 1 1 0 1 1 1 0 CHD5-like protein DUF768 PF05589.11 KII67275.1 - 0.085 12.9 8.8 11 6.1 0.0 4.4 1 1 1 4 4 4 0 Protein of unknown function (DUF768) TMEM100 PF16311.5 KII67279.1 - 0.17 11.5 0.1 0.31 10.6 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 DUF2062 PF09835.9 KII67280.1 - 0.093 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) CBM27 PF09212.10 KII67282.1 - 0.1 12.8 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate binding module 27 NKWYS PF10364.9 KII67283.1 - 0.011 15.9 0.4 0.024 14.8 0.4 1.6 1 0 0 1 1 1 0 Putative capsular polysaccharide synthesis protein DUF3212 PF11486.8 KII67283.1 - 0.14 12.2 1.6 0.34 10.9 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) MARVEL PF01284.23 KII67288.1 - 0.054 13.5 0.1 0.065 13.3 0.1 1.2 1 0 0 1 1 1 0 Membrane-associating domain RNase_PH PF01138.21 KII67289.1 - 1.9e-13 51.0 0.0 2.3e-13 50.8 0.0 1.0 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PrcB_C PF14343.6 KII67290.1 - 0.055 13.6 0.2 0.38 10.9 0.1 2.2 2 0 0 2 2 2 0 PrcB C-terminal EVI2A PF05399.11 KII67291.1 - 3.1e-05 23.7 6.6 3.6e-05 23.5 6.6 1.0 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) LAP1C PF05609.12 KII67291.1 - 0.0015 17.7 2.0 0.0018 17.5 2.0 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) DUF1180 PF06679.12 KII67291.1 - 0.0018 18.7 0.6 0.0025 18.2 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) RIFIN PF02009.16 KII67291.1 - 0.0024 17.8 1.5 0.0028 17.6 1.5 1.1 1 0 0 1 1 1 1 Rifin TMEM154 PF15102.6 KII67291.1 - 0.0041 17.0 15.5 0.021 14.8 15.5 1.9 1 1 0 1 1 1 1 TMEM154 protein family DUF3112 PF11309.8 KII67291.1 - 0.037 13.5 0.8 0.044 13.2 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Plasmodium_Vir PF05795.11 KII67291.1 - 0.039 13.4 4.2 0.044 13.2 4.2 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein BBS2_N PF14781.6 KII67291.1 - 0.047 13.6 1.6 0.076 12.9 1.6 1.5 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal MHYT PF03707.16 KII67291.1 - 0.051 13.7 0.5 0.082 13.1 0.5 1.2 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat AJAP1_PANP_C PF15298.6 KII67291.1 - 0.063 13.5 5.9 0.077 13.2 5.9 1.1 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Orf78 PF06024.12 KII67291.1 - 1.1 9.6 5.7 5.5 7.3 5.7 1.9 1 1 0 1 1 1 0 Orf78 (ac78) Kei1 PF08552.11 KII67291.1 - 2.8 7.8 6.8 4.5 7.1 6.8 1.4 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Shisa PF13908.6 KII67291.1 - 7.4 6.8 9.4 11 6.1 8.7 1.7 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF3377 PF11857.8 KII67293.1 - 0.00067 19.5 0.1 0.002 18.0 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) LAP1C PF05609.12 KII67293.1 - 0.0022 17.2 22.8 0.0026 16.9 22.8 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) DUF5383 PF17355.2 KII67293.1 - 0.0083 16.5 5.4 0.0083 16.5 5.4 3.7 1 1 3 4 4 4 1 Family of unknown function (DUF5383) TRP PF06011.12 KII67293.1 - 0.14 10.8 0.9 0.25 10.0 0.9 1.5 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel Macoilin PF09726.9 KII67293.1 - 0.62 8.6 18.8 0.78 8.2 18.8 1.1 1 0 0 1 1 1 0 Macoilin family RIFIN PF02009.16 KII67293.1 - 1.2 8.9 16.6 0.27 11.1 5.8 2.1 1 1 1 2 2 2 0 Rifin DUF572 PF04502.13 KII67293.1 - 3.9 7.0 22.5 5.3 6.6 22.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4083 PF13314.6 KII67293.1 - 4.4 7.3 6.8 0.73 9.8 2.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) GET2 PF08690.10 KII67293.1 - 4.6 6.8 27.8 9.9 5.7 27.8 1.9 1 1 0 1 1 1 0 GET complex subunit GET2 DUF966 PF06136.13 KII67293.1 - 8.4 6.0 26.0 11 5.6 26.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TetR_C_2 PF08361.11 KII67299.1 - 0.011 15.8 0.3 0.019 15.1 0.3 1.3 1 0 0 1 1 1 0 MAATS-type transcriptional repressor, C-terminal region SRTM1 PF15872.5 KII67299.1 - 0.11 12.7 0.3 0.17 12.0 0.3 1.3 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 zf_UBZ PF18439.1 KII67300.1 - 0.2 11.3 0.6 0.33 10.6 0.6 1.4 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger DDE_Tnp_IS1595 PF12762.7 KII67302.1 - 5.6e-14 52.4 0.5 1.1e-13 51.4 0.3 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.14 KII67302.1 - 0.0015 18.0 0.2 0.0019 17.7 0.2 1.1 1 0 0 1 1 1 1 Transposase IS66 family FAM60A PF15396.6 KII67303.1 - 1.7e-05 24.9 0.1 3.3e-05 24.0 0.0 1.4 2 0 0 2 2 2 1 Protein Family FAM60A TRM PF02005.16 KII67305.1 - 0.018 14.2 0.1 0.024 13.8 0.1 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase CRAL_TRIO_2 PF13716.6 KII67305.1 - 0.024 14.8 0.1 0.047 13.9 0.1 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain OMP_b-brl_3 PF14905.6 KII67306.1 - 0.011 14.7 0.6 0.017 14.1 0.6 1.2 1 0 0 1 1 1 0 Outer membrane protein beta-barrel family 2Fe-2S_thioredx PF01257.19 KII67306.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin DDE_Tnp_IS1595 PF12762.7 KII67307.1 - 2.1e-05 24.6 0.0 3.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII67308.1 - 2.1e-05 24.6 0.0 3.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain TMEM51 PF15345.6 KII67310.1 - 0.031 14.1 1.0 0.072 12.9 1.0 1.6 1 0 0 1 1 1 0 Transmembrane protein 51 TMEM154 PF15102.6 KII67310.1 - 0.44 10.4 7.4 3.3 7.6 6.1 2.3 2 0 0 2 2 2 0 TMEM154 protein family Lectin_leg-like PF03388.13 KII67312.1 - 0.00011 21.6 0.3 0.00012 21.5 0.3 1.1 1 0 0 1 1 1 1 Legume-like lectin family DUF596 PF04591.12 KII67312.1 - 0.072 13.2 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF596 Glyoxalase_2 PF12681.7 KII67314.1 - 0.016 15.1 0.5 0.021 14.8 0.5 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain DUF3641 PF12345.8 KII67314.1 - 0.27 11.3 1.2 0.63 10.1 1.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3641) Asp_protease_2 PF13650.6 KII67315.1 - 0.016 15.9 0.0 0.027 15.1 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease RED_C PF07807.11 KII67316.1 - 0.032 14.7 0.0 0.055 13.9 0.0 1.4 1 0 0 1 1 1 0 RED-like protein C-terminal region PRR22 PF15776.5 KII67317.1 - 0.3 10.4 0.1 0.42 9.9 0.1 1.1 1 0 0 1 1 1 0 Proline-rich protein family 22 IF-2B PF01008.17 KII67318.1 - 9.4e-61 205.5 0.2 1.1e-60 205.3 0.2 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family TMEM132D_C PF15706.5 KII67325.1 - 0.099 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Ank_2 PF12796.7 KII67326.1 - 1.5e-79 262.6 27.0 3.4e-11 43.6 0.5 8.5 2 1 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII67326.1 - 1.9e-69 229.2 24.1 4.2e-11 43.1 0.0 11.4 7 4 5 12 12 12 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 KII67326.1 - 3.2e-56 186.7 29.6 4.6e-08 33.2 0.0 14.1 4 2 11 15 15 15 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII67326.1 - 1.4e-55 178.7 35.5 3e-05 24.1 0.4 17.2 18 0 0 18 18 18 12 Ankyrin repeat Ank PF00023.30 KII67326.1 - 8.4e-50 165.1 36.6 4.3e-06 26.9 0.0 15.6 16 0 0 16 16 16 11 Ankyrin repeat Ion_trans PF00520.31 KII67326.1 - 4.3e-09 36.0 26.4 7.6e-09 35.2 26.4 1.4 1 0 0 1 1 1 1 Ion transport protein Suppressor_APC PF11414.8 KII67332.1 - 0.065 13.3 1.1 0.11 12.6 1.1 1.3 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein eIF-5_eIF-2B PF01873.17 KII67332.1 - 0.18 11.7 3.1 0.26 11.2 0.7 1.9 1 1 1 2 2 2 0 Domain found in IF2B/IF5 Molybdopterin PF00384.22 KII67334.1 - 7.9e-49 166.8 0.0 2.9e-24 85.8 0.0 2.1 1 1 0 2 2 2 2 Molybdopterin oxidoreductase Fer2_4 PF13510.6 KII67334.1 - 3.8e-17 62.1 0.0 8e-17 61.1 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 KII67334.1 - 3.4e-16 58.5 0.6 8.4e-16 57.2 0.6 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 KII67334.1 - 2.5e-09 37.7 0.0 6.1e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 KII67334.1 - 5.2e-09 35.9 1.6 6.3e-09 35.7 0.1 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4 PF00037.27 KII67334.1 - 0.11 12.4 2.4 12 5.9 0.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Cys_rich_CWC PF14375.6 KII67334.1 - 1.3 9.5 7.7 1.1 9.7 3.6 2.6 2 0 0 2 2 2 0 Cysteine-rich CWC Sod_Fe_C PF02777.18 KII67335.1 - 3.6e-29 100.9 2.8 1.5e-28 99.0 0.2 2.1 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 KII67335.1 - 3.8e-24 85.0 4.7 5.2e-24 84.5 2.9 2.0 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain PurA PF04845.13 KII67336.1 - 0.0025 17.2 0.9 0.068 12.5 0.0 2.4 2 1 0 2 2 2 2 PurA ssDNA and RNA-binding protein DDE_3 PF13358.6 KII67338.1 - 2.8e-12 46.6 0.0 5.2e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease TrmB PF01978.19 KII67338.1 - 0.0075 16.1 0.1 0.051 13.5 0.0 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB PAX PF00292.18 KII67338.1 - 0.0094 15.9 0.2 0.016 15.1 0.2 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 KII67338.1 - 0.041 14.5 0.1 0.27 11.9 0.0 2.4 2 1 1 3 3 3 0 Homeodomain-like domain DUF3634 PF12321.8 KII67338.1 - 0.078 13.4 0.2 0.19 12.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3634) HTH_23 PF13384.6 KII67338.1 - 0.079 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_28 PF13518.6 KII67338.1 - 0.14 12.3 0.5 0.42 10.8 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain ORC5_C PF14630.6 KII67339.1 - 0.16 11.5 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus PTPS PF01242.19 KII67341.1 - 0.05 13.6 0.5 0.23 11.4 0.1 2.0 1 1 1 2 2 2 0 6-pyruvoyl tetrahydropterin synthase Tox-REase-2 PF15646.6 KII67341.1 - 0.13 12.4 0.2 0.23 11.6 0.2 1.3 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 2 WD40 PF00400.32 KII67342.1 - 0.0081 17.0 4.9 2.9 8.9 0.6 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat SeleniumBinding PF11524.8 KII67345.1 - 0.021 15.2 0.1 0.069 13.6 0.1 1.9 1 0 0 1 1 1 0 Selenium binding protein PilA4 PF18682.1 KII67346.1 - 0.019 15.3 3.2 0.21 12.0 0.2 2.3 2 0 0 2 2 2 0 Pilin A4 Orf78 PF06024.12 KII67348.1 - 0.12 12.7 0.4 0.12 12.7 0.4 2.0 2 1 0 2 2 2 0 Orf78 (ac78) Cofilin_ADF PF00241.20 KII67350.1 - 5.7e-14 51.9 0.5 5.7e-14 51.9 0.5 1.7 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein DUF1307 PF06998.11 KII67350.1 - 0.15 12.1 2.3 0.11 12.5 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1307) RRM_1 PF00076.22 KII67352.1 - 1.4e-26 92.1 0.7 2.6e-12 46.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII67352.1 - 2.4e-08 34.0 0.2 0.002 18.2 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 KII67352.1 - 0.0072 16.0 0.0 5.2 6.8 0.0 2.5 2 0 0 2 2 2 2 Ribonuclease B OB domain PHM7_cyt PF14703.6 KII67352.1 - 0.072 13.3 0.0 1.1 9.5 0.0 2.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RVT_1 PF00078.27 KII67355.1 - 9.3e-17 61.3 0.0 1.5e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 KII67355.1 - 2.2e-05 24.7 0.1 5.3e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII67355.1 - 0.00011 22.7 0.0 0.0002 21.9 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII67355.1 - 0.0032 18.1 0.0 0.0058 17.2 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease cwf21 PF08312.12 KII67357.1 - 0.01 16.0 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 0 cwf21 domain TTKRSYEDQ PF10212.9 KII67357.1 - 0.023 13.7 0.5 0.04 12.9 0.5 1.4 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Rota_NSP4 PF01452.16 KII67357.1 - 0.031 13.9 0.1 0.045 13.4 0.1 1.4 1 1 0 1 1 1 0 Rotavirus non structural protein DLP_helical PF18709.1 KII67359.1 - 0.0041 16.4 0.1 0.0049 16.1 0.1 1.1 1 0 0 1 1 1 1 Dynamin-like helical domain PuR_N PF09182.10 KII67359.1 - 0.16 11.9 0.8 0.29 11.1 0.1 1.8 2 1 0 2 2 2 0 Bacterial purine repressor, N-terminal rve PF00665.26 KII67360.1 - 1.9e-14 53.9 0.0 3.3e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII67360.1 - 0.016 15.0 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain RT_RNaseH_2 PF17919.1 KII67361.1 - 4.1e-31 107.0 0.1 5.6e-31 106.5 0.1 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67361.1 - 7.1e-29 100.2 0.0 1.1e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Tannase PF07519.11 KII67361.1 - 0.014 14.4 0.0 0.015 14.3 0.0 1.1 1 0 0 1 1 1 0 Tannase and feruloyl esterase Peptidase_A17 PF05380.13 KII67361.1 - 0.056 13.4 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 Pao retrotransposon peptidase Sua5_yciO_yrdC PF01300.18 KII67361.1 - 0.065 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Telomere recombination RVT_1 PF00078.27 KII67362.1 - 9.9e-14 51.4 0.8 1.7e-08 34.2 0.1 2.9 3 0 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII67362.1 - 9e-11 41.7 0.0 2.2e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67362.1 - 0.027 14.7 0.0 0.068 13.5 0.0 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase PDGF_N PF04692.13 KII67362.1 - 0.28 12.0 1.1 1.2 10.0 0.1 2.4 3 0 0 3 3 3 0 Platelet-derived growth factor, N terminal region RVT_1 PF00078.27 KII67363.1 - 0.019 14.5 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) OSTMP1 PF09777.9 KII67365.1 - 0.02 14.3 0.1 0.034 13.5 0.1 1.3 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor Antimicrobial19 PF08225.11 KII67368.1 - 0.08 12.6 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 Pseudin antimicrobial peptide zf-met2 PF12907.7 KII67370.1 - 0.0082 16.3 0.5 0.013 15.6 0.5 1.3 1 0 0 1 1 1 1 Zinc-binding SH3_11 PF18103.1 KII67371.1 - 0.0013 18.8 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 Retroviral integrase C-terminal SH3 domain MLVIN_C PF18697.1 KII67371.1 - 0.013 15.6 1.0 0.024 14.7 1.0 1.4 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Tcp11 PF05794.13 KII67372.1 - 1.4e-12 47.5 0.7 1.6e-12 47.3 0.7 1.0 1 0 0 1 1 1 1 T-complex protein 11 DNA_pol3_delta2 PF13177.6 KII67373.1 - 3.4e-06 26.9 0.8 8.7e-06 25.6 0.1 1.9 2 1 0 2 2 2 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.13 KII67373.1 - 5.2e-05 23.1 0.4 9.5e-05 22.2 0.4 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 KII67373.1 - 0.061 13.7 0.2 0.16 12.4 0.0 1.8 2 0 0 2 2 2 0 Replication factor C C-terminal domain AAA_6 PF12774.7 KII67376.1 - 6.4e-123 409.9 8.2 9e-121 402.8 0.1 4.9 6 0 0 6 6 4 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KII67376.1 - 8.1e-89 298.5 12.8 8.1e-89 298.5 12.8 6.3 8 0 0 8 8 7 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 KII67376.1 - 2.8e-59 199.9 1.7 2.8e-59 199.9 1.7 4.0 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 KII67376.1 - 6e-45 153.0 1.5 2.3e-39 134.8 0.0 5.4 5 1 0 5 5 5 2 P-loop containing dynein motor region AAA_8 PF12780.7 KII67376.1 - 8e-41 140.1 2.1 3.1e-38 131.6 2.2 3.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KII67376.1 - 2.5e-39 135.3 0.2 2.5e-39 135.3 0.2 2.5 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 KII67376.1 - 1.4e-38 132.8 9.4 3.3e-38 131.6 9.4 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 KII67376.1 - 1.3e-34 119.4 0.1 4.3e-34 117.7 0.1 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KII67376.1 - 1.7e-31 109.1 0.0 3e-10 40.2 0.0 6.5 6 1 0 6 6 5 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 KII67376.1 - 2.4e-27 95.4 1.6 9.3e-25 87.0 0.0 5.0 5 0 0 5 5 4 1 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 KII67376.1 - 3.3e-15 56.7 0.7 3e-06 27.7 0.0 6.2 6 0 0 6 6 5 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KII67376.1 - 2.4e-12 47.3 2.2 9.4e-06 25.9 0.0 7.3 7 0 0 7 7 7 1 AAA domain Dynein_AAA_lid PF17852.1 KII67376.1 - 9.9e-10 38.6 0.8 7.6e-09 35.7 0.8 2.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 KII67376.1 - 1.5e-07 32.0 0.0 0.095 13.1 0.0 4.6 4 0 0 4 4 3 1 AAA ATPase domain AAA_18 PF13238.6 KII67376.1 - 3.9e-06 27.4 0.1 0.017 15.6 0.0 4.9 5 0 0 5 5 4 1 AAA domain RNA_helicase PF00910.22 KII67376.1 - 0.00024 21.4 0.0 0.64 10.4 0.0 4.2 3 0 0 3 3 3 1 RNA helicase Mg_chelatase PF01078.21 KII67376.1 - 0.00052 19.5 0.0 0.045 13.1 0.0 3.2 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KII67376.1 - 0.00089 19.4 0.0 0.08 13.1 0.0 3.6 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 KII67376.1 - 0.0011 18.6 0.1 0.11 12.0 0.0 3.6 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KII67376.1 - 0.0016 18.2 0.0 1.5 8.5 0.0 3.6 4 0 0 4 4 4 1 AAA domain IstB_IS21 PF01695.17 KII67376.1 - 0.0016 18.2 0.3 0.029 14.1 0.0 3.1 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_19 PF13245.6 KII67376.1 - 0.0022 18.3 0.5 0.65 10.3 0.0 4.1 4 0 0 4 4 4 1 AAA domain AAA_28 PF13521.6 KII67376.1 - 0.0023 18.2 0.1 2.3 8.4 0.0 3.5 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 KII67376.1 - 0.0033 17.4 0.0 2.1 8.3 0.0 3.5 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 KII67376.1 - 0.0077 16.4 0.0 0.043 13.9 0.0 2.4 3 0 0 3 3 1 1 AAA domain (Cdc48 subfamily) Utp12 PF04003.12 KII67376.1 - 0.0077 16.5 14.6 0.036 14.4 0.0 6.4 7 0 0 7 7 5 1 Dip2/Utp12 Family AAA_14 PF13173.6 KII67376.1 - 0.0083 16.2 0.0 0.0083 16.2 0.0 5.3 7 0 0 7 7 3 1 AAA domain T2SSE PF00437.20 KII67376.1 - 0.0093 15.1 0.0 0.33 10.0 0.0 2.8 2 0 0 2 2 2 1 Type II/IV secretion system protein NACHT PF05729.12 KII67376.1 - 0.012 15.5 0.0 0.068 13.1 0.0 2.4 1 0 0 1 1 1 0 NACHT domain Roc PF08477.13 KII67376.1 - 0.014 15.6 0.1 16 5.7 0.0 3.6 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 KII67376.1 - 0.016 15.0 0.0 5.7 6.6 0.0 3.6 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 KII67376.1 - 0.056 14.0 5.8 1.2 9.6 0.0 5.0 5 0 0 5 5 5 0 ABC transporter AAA_29 PF13555.6 KII67376.1 - 0.065 13.0 0.2 1.2 9.0 0.0 3.0 3 0 0 3 3 2 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 KII67376.1 - 0.14 11.4 0.0 1.1 8.5 0.0 2.5 3 0 0 3 3 3 0 Zeta toxin MtrG PF04210.13 KII67376.1 - 0.21 11.5 0.7 4.3 7.3 0.0 3.2 3 0 0 3 3 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G ERM PF00769.19 KII67376.1 - 2.9 7.6 19.6 0.95 9.2 6.9 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family CLZ PF16526.5 KII67376.1 - 9.7 6.6 7.9 1e+02 3.3 3.8 3.9 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Saf_2TM PF18303.1 KII67377.1 - 0.032 13.8 0.6 0.047 13.3 0.6 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Collectrin PF16959.5 KII67377.1 - 0.041 13.7 0.6 0.048 13.4 0.6 1.2 1 0 0 1 1 1 0 Renal amino acid transporter PRIMA1 PF16101.5 KII67377.1 - 0.043 13.8 0.3 0.054 13.5 0.3 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Arif-1 PF06770.11 KII67377.1 - 0.047 13.4 0.4 0.075 12.7 0.4 1.2 1 0 0 1 1 1 0 Actin-rearrangement-inducing factor (Arif-1) ECSCR PF15820.5 KII67377.1 - 0.27 11.1 5.1 0.21 11.5 3.0 1.8 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator MULE PF10551.9 KII67378.1 - 4.6e-14 52.6 0.0 1e-13 51.5 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain SNAP PF14938.6 KII67381.1 - 2.8e-39 135.3 12.4 3.1e-39 135.1 12.4 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII67381.1 - 4.1e-05 23.8 9.8 0.021 15.1 0.1 3.2 2 1 2 4 4 4 3 Tetratricopeptide repeat KorB PF08535.10 KII67381.1 - 0.02 14.9 0.2 3.1 7.9 0.0 2.7 3 0 0 3 3 3 0 KorB domain Nudc_N PF14050.6 KII67381.1 - 0.072 13.1 0.0 1.1 9.3 0.0 2.5 2 0 0 2 2 2 0 N-terminal conserved domain of Nudc. Sel1 PF08238.12 KII67381.1 - 0.23 12.2 5.1 4.7 8.0 0.0 3.9 4 1 1 5 5 5 0 Sel1 repeat TPR_8 PF13181.6 KII67381.1 - 0.34 11.3 0.1 0.34 11.3 0.1 6.0 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII67381.1 - 0.58 10.4 16.1 9.7 6.6 0.2 5.8 5 2 1 6 6 6 0 Tetratricopeptide repeat Thymidylate_kin PF02223.17 KII67382.1 - 5.4e-20 71.8 0.0 6.1e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase RNase_HII PF01351.18 KII67382.1 - 0.16 11.8 0.1 0.2 11.5 0.1 1.1 1 0 0 1 1 1 0 Ribonuclease HII MULE PF10551.9 KII67386.1 - 2.2e-07 31.2 0.1 6.2e-07 29.7 0.0 1.8 2 0 0 2 2 2 1 MULE transposase domain DHR-2 PF06920.13 KII67387.1 - 0.063 11.9 0.1 0.086 11.5 0.1 1.1 1 0 0 1 1 1 0 Dock homology region 2 DDE_3 PF13358.6 KII67388.1 - 6e-12 45.5 0.0 7.3e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease BLUF PF04940.12 KII67389.1 - 3.8e-20 71.8 0.1 6.8e-20 71.0 0.1 1.4 1 0 0 1 1 1 1 Sensors of blue-light using FAD EAL PF00563.20 KII67389.1 - 1.2e-07 31.5 0.1 4e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 EAL domain EAL PF00563.20 KII67390.1 - 1.4e-29 103.3 0.0 1.5e-29 103.2 0.0 1.0 1 0 0 1 1 1 1 EAL domain DUF3330 PF11809.8 KII67390.1 - 0.035 14.2 0.0 0.048 13.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) Anti-adapt_IraP PF10796.9 KII67391.1 - 7e-30 103.4 8.0 8.5e-30 103.2 8.0 1.1 1 0 0 1 1 1 1 Sigma-S stabilisation anti-adaptor protein Lge1 PF11488.8 KII67391.1 - 0.15 12.2 3.5 0.19 11.9 0.9 1.9 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DUF1852 PF08908.11 KII67392.1 - 9.2e-183 606.5 2.8 1e-182 606.4 2.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1852) Meth_synt_2 PF01717.18 KII67393.1 - 4.5e-32 111.6 0.0 1.2e-31 110.2 0.0 1.6 1 1 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain CNP1 PF08750.11 KII67393.1 - 0.00095 19.1 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 CNP1-like family Meth_synt_1 PF08267.12 KII67393.1 - 0.0019 17.7 0.0 0.0044 16.6 0.0 1.6 2 1 0 2 2 2 1 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 KII67393.1 - 0.0078 15.4 0.0 0.013 14.7 0.0 1.3 1 1 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Haemagg_act PF05860.13 KII67394.1 - 2.5e-22 79.0 0.8 2.5e-22 79.0 0.8 3.2 3 0 0 3 3 3 1 haemagglutination activity domain Fil_haemagg PF05594.14 KII67394.1 - 1.4 9.5 49.8 0.091 13.3 6.2 8.1 7 1 1 8 8 8 0 Haemagluttinin repeat Utp12 PF04003.12 KII67399.1 - 4.3e-11 43.1 0.4 7e-11 42.4 0.4 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family WAPL PF07814.13 KII67399.1 - 0.057 12.2 1.3 0.066 12.0 1.3 1.1 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin RT_RNaseH_2 PF17919.1 KII67400.1 - 0.018 15.1 0.2 0.094 12.8 0.1 1.9 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase Pkinase_fungal PF17667.1 KII67401.1 - 0.12 11.1 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase DUF5438 PF17506.2 KII67402.1 - 0.042 14.2 2.0 0.055 13.8 0.4 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5438) DUF521 PF04412.13 KII67404.1 - 0.02 13.7 0.1 0.023 13.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Sigma54_activ_2 PF14532.6 KII67404.1 - 0.12 12.5 0.1 0.15 12.2 0.1 1.4 1 1 0 1 1 1 0 Sigma-54 interaction domain Ldl_recept_a PF00057.18 KII67405.1 - 0.0057 16.8 4.8 0.0057 16.8 4.8 2.0 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A RVT_1 PF00078.27 KII67407.1 - 0.00072 19.1 0.1 0.0011 18.5 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII67409.1 - 4.7e-11 42.6 0.4 4.7e-11 42.6 0.4 1.6 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII67409.1 - 0.0052 17.0 0.0 0.019 15.1 0.0 1.9 1 1 1 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII67409.1 - 0.099 12.9 0.4 0.17 12.1 0.4 1.4 1 0 0 1 1 1 0 H2C2 zinc finger TMEM18 PF14770.6 KII67410.1 - 0.041 13.9 0.2 0.058 13.4 0.2 1.3 1 0 0 1 1 1 0 Transmembrane protein 18 RIH_assoc PF08454.11 KII67411.1 - 2.5e-05 24.1 0.4 5.5e-05 23.0 0.2 1.7 2 0 0 2 2 2 1 RyR and IP3R Homology associated DDE_3 PF13358.6 KII67412.1 - 9.1e-27 93.6 0.0 1.1e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Colicin_Pyocin PF01320.18 KII67412.1 - 0.036 14.2 0.1 0.062 13.4 0.1 1.4 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein DUF2024 PF09630.10 KII67412.1 - 0.08 12.8 0.2 0.28 11.1 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) Myb_DNA-bind_6 PF13921.6 KII67413.1 - 0.00018 21.7 1.0 0.014 15.6 0.0 3.1 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 KII67413.1 - 0.017 15.3 0.3 0.065 13.4 0.0 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain Pkinase PF00069.25 KII67414.1 - 0.0059 16.0 0.0 0.0068 15.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain PCNA_N PF00705.18 KII67418.1 - 4.8e-37 126.5 0.7 8.7e-37 125.7 0.7 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 KII67418.1 - 6.2e-36 123.4 0.3 1.6e-33 115.6 0.0 2.3 2 1 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 KII67418.1 - 0.00031 19.9 1.3 0.0043 16.1 0.1 2.1 1 1 1 2 2 2 1 Repair protein Rad1/Rec1/Rad17 DNA_pol3_beta_2 PF02767.16 KII67418.1 - 0.0021 18.2 0.1 0.43 10.8 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase III beta subunit, central domain Rad9 PF04139.13 KII67418.1 - 0.013 14.9 0.0 0.024 14.1 0.0 1.6 1 1 0 1 1 1 0 Rad9 Hus1 PF04005.12 KII67418.1 - 0.025 13.7 0.2 0.041 13.0 0.2 1.8 1 1 0 1 1 1 0 Hus1-like protein Tetraspanin PF00335.20 KII67419.1 - 0.00036 20.3 13.8 0.00043 20.1 13.8 1.1 1 0 0 1 1 1 1 Tetraspanin family FHA PF00498.26 KII67420.1 - 1.2e-15 57.6 0.0 2.4e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KII67420.1 - 0.00092 19.5 0.0 0.003 17.9 0.0 1.7 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Presenilin PF01080.17 KII67420.1 - 1.5 7.5 8.2 1.6 7.4 8.2 1.1 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 KII67420.1 - 8.2 5.2 12.0 9.2 5.0 12.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain HLH PF00010.26 KII67422.1 - 5.8e-08 32.6 0.0 1.8e-07 31.0 0.0 1.9 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain ZapB PF06005.12 KII67422.1 - 0.00055 20.3 0.1 0.0018 18.7 0.1 1.8 1 0 0 1 1 1 1 Cell division protein ZapB DivIC PF04977.15 KII67422.1 - 0.00062 19.5 1.4 0.002 17.8 0.4 2.3 2 0 0 2 2 2 1 Septum formation initiator HALZ PF02183.18 KII67422.1 - 0.0059 16.8 2.6 0.006 16.8 0.9 1.9 2 0 0 2 2 2 1 Homeobox associated leucine zipper DUF2205 PF10224.9 KII67422.1 - 0.009 16.0 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 Short coiled-coil protein KASH_CCD PF14662.6 KII67422.1 - 0.013 15.3 0.2 0.04 13.7 0.2 1.7 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH GIT_CC PF16559.5 KII67422.1 - 0.036 13.9 0.7 0.075 12.9 0.7 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4201 PF13870.6 KII67422.1 - 0.054 13.2 0.0 0.054 13.2 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4201) bZIP_1 PF00170.21 KII67422.1 - 0.063 13.4 1.8 0.26 11.4 0.2 2.7 2 0 0 2 2 2 0 bZIP transcription factor Stirrup PF09061.6 KII67422.1 - 0.064 13.5 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 Stirrup PBP PF01161.20 KII67423.1 - 1.5e-19 70.6 0.0 2.1e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PBP PF01161.20 KII67424.1 - 2.3e-18 66.8 0.0 3e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DDE_Tnp_IS1595 PF12762.7 KII67425.1 - 0.0079 16.2 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain Sec23_trunk PF04811.15 KII67426.1 - 2.3e-55 187.8 0.0 3.9e-55 187.1 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 KII67426.1 - 2.6e-26 92.2 1.3 4.5e-26 91.4 0.3 1.9 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KII67426.1 - 8.6e-24 83.3 0.4 2.2e-23 82.0 0.4 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 KII67426.1 - 5.4e-15 55.2 7.2 1.5e-14 53.7 7.2 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KII67426.1 - 4.8e-05 23.2 0.0 0.00011 22.0 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 KII67426.1 - 0.00046 20.8 0.0 1.2 9.8 0.0 2.6 2 0 0 2 2 2 2 von Willebrand factor type A domain PBP PF01161.20 KII67427.1 - 4.9e-21 75.4 0.1 6.3e-21 75.1 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF3012 PF11216.8 KII67427.1 - 0.079 13.0 0.2 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3012) Gal-3-0_sulfotr PF06990.11 KII67428.1 - 7.1e-34 117.4 1.3 9.5e-34 116.9 1.3 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase OTCace_N PF02729.21 KII67428.1 - 0.081 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain UQ_con PF00179.26 KII67429.1 - 4.4e-20 71.8 0.0 3e-18 65.8 0.0 2.3 2 1 0 2 2 2 2 Ubiquitin-conjugating enzyme Inositol_P PF00459.25 KII67430.1 - 2.1e-34 119.3 0.0 2.7e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family Proteasome PF00227.26 KII67431.1 - 3.8e-31 108.0 0.0 4.3e-31 107.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TcdB_N PF12918.7 KII67432.1 - 0.014 15.6 0.2 0.036 14.3 0.2 1.6 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain DUF1870 PF08965.10 KII67432.1 - 0.098 12.7 0.4 13 5.9 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1870) Neurokinin_B PF03823.14 KII67432.1 - 0.14 12.2 0.1 0.36 10.9 0.1 1.7 1 0 0 1 1 1 0 Neurokinin B BRCT_2 PF16589.5 KII67433.1 - 2.9e-07 30.8 0.3 5.9e-06 26.6 0.1 2.2 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KII67433.1 - 3.7e-05 24.0 0.2 0.0071 16.7 0.1 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Ank_4 PF13637.6 KII67434.1 - 1.4e-14 54.2 0.0 1.2e-09 38.5 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KII67434.1 - 3e-13 50.2 0.0 7.5e-13 48.9 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KII67434.1 - 8e-12 45.0 0.1 1.8e-07 31.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KII67434.1 - 8.1e-10 38.8 0.1 2.2e-09 37.4 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII67434.1 - 1.4e-09 37.4 0.0 1.8e-07 30.9 0.0 3.4 3 1 0 3 3 3 1 Ankyrin repeat Shigella_OspC PF06128.11 KII67434.1 - 0.011 15.5 0.0 0.82 9.3 0.0 2.3 1 1 1 2 2 2 0 Shigella flexneri OspC protein ORC2 PF04084.14 KII67436.1 - 3.3e-36 124.9 6.4 4.2e-29 101.5 1.8 2.1 1 1 1 2 2 2 2 Origin recognition complex subunit 2 NPHI_C PF08469.10 KII67436.1 - 0.01 15.8 1.0 0.2 11.6 0.5 2.6 2 0 0 2 2 2 0 Nucleoside triphosphatase I C-terminal Collagen PF01391.18 KII67437.1 - 3.8e-08 33.0 26.0 5e-08 32.6 26.0 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) COQ7 PF03232.13 KII67438.1 - 2.7e-35 121.7 0.1 2.9e-35 121.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 ATP13 PF12921.7 KII67439.1 - 0.029 14.2 0.3 0.24 11.2 0.1 2.1 1 1 1 2 2 2 0 Mitochondrial ATPase expression zf-C3HC4_3 PF13920.6 KII67440.1 - 3.9e-10 39.4 18.0 5.9e-10 38.9 18.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII67440.1 - 0.16 11.8 18.3 0.29 11.0 18.3 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Rhodanese PF00581.20 KII67441.1 - 1.3e-12 48.2 0.1 3.1e-12 46.9 0.0 1.7 2 0 0 2 2 2 1 Rhodanese-like domain DUF498 PF04430.14 KII67442.1 - 2.9e-16 59.5 0.0 3.2e-16 59.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) tRNA-synt_1 PF00133.22 KII67444.1 - 1.3e-214 713.9 1.0 1.9e-214 713.4 0.2 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KII67444.1 - 5.7e-19 68.6 0.1 1.7e-18 67.1 0.0 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KII67444.1 - 9.6e-13 47.6 6.0 0.00014 20.7 0.3 3.8 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 KII67444.1 - 0.013 14.8 0.0 0.036 13.4 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain DUF3164 PF11363.8 KII67446.1 - 0.041 13.5 0.1 0.087 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3164) Bromodomain PF00439.25 KII67448.1 - 3.1e-18 65.6 0.6 2.6e-17 62.7 0.1 2.5 2 0 0 2 2 2 1 Bromodomain Auxin_resp PF06507.13 KII67448.1 - 0.012 15.8 0.7 0.049 13.9 0.1 2.2 2 0 0 2 2 2 0 Auxin response factor Kazal_1 PF00050.21 KII67448.1 - 0.16 12.0 0.0 0.5 10.4 0.0 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KII67448.1 - 0.24 11.6 0.9 0.7 10.1 0.0 2.3 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain WD40 PF00400.32 KII67448.1 - 0.37 11.8 2.0 0.43 11.5 0.3 2.1 2 0 0 2 2 2 0 WD domain, G-beta repeat TFIIE_alpha PF02002.17 KII67449.1 - 3e-13 49.5 0.5 3e-13 49.5 0.5 1.9 2 0 0 2 2 2 1 TFIIE alpha subunit TFIIE-A_C PF11521.8 KII67449.1 - 5.3e-10 39.5 5.8 1.7e-09 37.8 5.1 2.3 2 1 0 2 2 2 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.12 KII67449.1 - 0.00015 21.2 1.5 0.00039 19.9 1.5 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding SusD-like_3 PF14322.6 KII67449.1 - 0.0032 17.8 0.2 0.0067 16.8 0.2 1.6 1 0 0 1 1 1 1 Starch-binding associating with outer membrane Ephrin_rec_like PF07699.13 KII67449.1 - 0.12 12.1 4.4 0.29 10.9 4.4 1.6 1 1 0 1 1 1 0 Putative ephrin-receptor like RRM_1 PF00076.22 KII67450.1 - 0.0011 18.8 0.1 1.4 8.8 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF16 PF01519.16 KII67450.1 - 8 7.0 17.6 1.5e+02 2.9 18.1 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 HSP20 PF00011.21 KII67452.1 - 1.7e-22 79.5 1.2 2.6e-13 50.0 0.0 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII67452.1 - 2e-06 27.2 0.0 0.00038 20.0 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA HTH_23 PF13384.6 KII67453.1 - 4e-06 26.5 0.0 8.9e-06 25.3 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 KII67453.1 - 6.8e-06 25.7 0.0 0.00042 20.0 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 KII67453.1 - 6.9e-06 26.0 0.0 9.7e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 KII67453.1 - 1.3e-05 25.2 0.0 2.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain PAX PF00292.18 KII67453.1 - 0.0036 17.2 0.1 0.0044 17.0 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.16 KII67453.1 - 0.015 15.3 0.3 0.019 15.0 0.3 1.2 1 0 0 1 1 1 0 Transposase HTH_32 PF13565.6 KII67453.1 - 0.021 15.4 0.0 0.074 13.7 0.0 1.8 1 1 1 2 2 2 0 Homeodomain-like domain HTH_Crp_2 PF13545.6 KII67453.1 - 0.022 14.7 0.1 0.05 13.6 0.0 1.6 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_11 PF08279.12 KII67453.1 - 0.046 13.7 0.3 0.081 12.9 0.3 1.4 1 0 0 1 1 1 0 HTH domain HTH_7 PF02796.15 KII67453.1 - 0.05 13.7 1.6 0.16 12.0 0.1 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase TrmB PF01978.19 KII67453.1 - 0.082 12.8 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DDE_3 PF13358.6 KII67456.1 - 2.7e-10 40.2 0.0 3.1e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII67459.1 - 0.00033 20.4 0.0 0.00043 20.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease GvpD PF07088.11 KII67462.1 - 0.012 14.2 0.1 0.014 14.0 0.1 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein INCENP_N PF12178.8 KII67462.1 - 0.12 12.4 0.2 0.29 11.2 0.2 1.7 1 0 0 1 1 1 0 Chromosome passenger complex (CPC) protein INCENP N terminal Flg_new PF09479.10 KII67463.1 - 0.21 11.8 2.5 36 4.6 0.1 3.2 3 0 0 3 3 3 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) RPM2 PF08579.11 KII67464.1 - 0.0084 16.5 1.5 0.011 16.2 0.9 1.5 1 1 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) PRANC PF09372.10 KII67469.1 - 0.00069 19.9 1.5 0.0014 18.9 1.4 1.6 1 1 0 1 1 1 1 PRANC domain TraF PF13728.6 KII67471.1 - 1e-13 51.6 0.1 1.4e-13 51.2 0.1 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 KII67471.1 - 0.00062 20.2 0.5 0.0018 18.7 0.5 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Glutaredoxin PF00462.24 KII67471.1 - 0.019 15.2 0.0 0.034 14.3 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin Redoxin PF08534.10 KII67471.1 - 0.033 13.9 0.0 0.2 11.4 0.0 1.9 1 1 1 2 2 2 0 Redoxin DSBA PF01323.20 KII67471.1 - 0.034 13.9 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 DSBA-like thioredoxin domain DUF836 PF05768.14 KII67471.1 - 0.041 14.3 0.0 0.05 14.0 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_4 PF13462.6 KII67471.1 - 0.058 13.6 0.0 0.094 12.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Thioredoxin PF00085.20 KII67471.1 - 0.066 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_3 PF13192.6 KII67471.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain sCache_3_2 PF17203.4 KII67473.1 - 1.1e-08 35.3 0.0 1.3e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Single cache domain 3 HATPase_c_5 PF14501.6 KII67474.1 - 1.2e-05 25.1 0.2 0.00012 22.0 0.1 2.3 2 0 0 2 2 2 1 GHKL domain SPOB_a PF14689.6 KII67474.1 - 5.2e-05 22.9 2.3 0.00013 21.6 2.3 1.6 1 0 0 1 1 1 1 Sensor_kinase_SpoOB-type, alpha-helical domain PAS_7 PF12860.7 KII67474.1 - 0.0019 18.3 0.0 0.0038 17.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 KII67474.1 - 0.003 17.6 0.0 0.0098 15.9 0.0 1.9 2 0 0 2 2 2 1 PAS fold vATP-synt_AC39 PF01992.16 KII67474.1 - 0.0071 15.9 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit PAS_8 PF13188.7 KII67474.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 PAS domain HsdM_N PF12161.8 KII67474.1 - 0.018 15.7 0.0 0.033 14.8 0.0 1.5 1 0 0 1 1 1 0 HsdM N-terminal domain PAS_9 PF13426.7 KII67474.1 - 0.056 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 PAS domain RRM_occluded PF16842.5 KII67474.1 - 0.093 12.6 0.1 7 6.6 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif PAS_4 PF08448.10 KII67474.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 PAS fold Na_sulph_symp PF00939.19 KII67475.1 - 2.9e-77 260.7 11.9 3.5e-77 260.4 11.9 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KII67475.1 - 3.7e-05 23.1 13.3 3.7e-05 23.1 13.3 2.0 1 1 1 2 2 2 1 Citrate transporter PrpF PF04303.13 KII67476.1 - 1.8e-134 448.4 1.3 2e-134 448.3 1.3 1.0 1 0 0 1 1 1 1 PrpF protein Pro_racemase PF05544.11 KII67476.1 - 0.0017 17.5 0.1 0.0042 16.2 0.0 1.6 2 0 0 2 2 2 1 Proline racemase LysR_substrate PF03466.20 KII67477.1 - 1.6e-42 145.2 0.0 2.3e-42 144.7 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 KII67477.1 - 4e-21 74.7 1.5 8.4e-21 73.7 0.2 2.2 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_8 PF02954.19 KII67477.1 - 0.032 14.0 0.0 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family PBP_like PF12727.7 KII67477.1 - 0.037 13.1 0.0 1.3 8.1 0.0 2.3 1 1 1 2 2 2 0 PBP superfamily domain HTH_30 PF13556.6 KII67477.1 - 0.079 12.8 0.1 0.26 11.1 0.0 1.8 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain Serpin PF00079.20 KII67479.1 - 1.2e-43 149.8 4.0 1.5e-43 149.5 4.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF726 PF05277.12 KII67480.1 - 0.041 12.8 0.0 0.085 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Snapin_Pallidin PF14712.6 KII67480.1 - 0.086 13.3 1.2 19 5.7 0.0 2.6 2 0 0 2 2 2 0 Snapin/Pallidin DUF5377 PF17347.2 KII67480.1 - 0.13 12.6 2.3 17 5.8 0.2 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5377) KIF1B PF12423.8 KII67481.1 - 0.53 10.8 5.6 3.8 8.0 1.4 2.7 2 0 0 2 2 2 0 Kinesin protein 1B Serpin PF00079.20 KII67483.1 - 1.4e-24 87.1 0.7 1.6e-24 87.0 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII67484.1 - 0.0089 15.4 0.1 0.0094 15.3 0.1 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RT_RNaseH_2 PF17919.1 KII67485.1 - 2.7e-31 107.5 0.0 6.2e-31 106.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67485.1 - 1.6e-28 99.0 0.0 3.6e-28 97.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67485.1 - 4.2e-28 98.4 0.0 7.2e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII67485.1 - 1.7e-22 79.8 0.1 7.6e-22 77.7 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67485.1 - 4.3e-15 55.6 0.9 1.6e-14 53.7 0.9 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII67485.1 - 0.00016 22.1 0.0 0.00038 21.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 KII67485.1 - 0.00048 19.8 0.0 0.0012 18.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII67485.1 - 0.0082 16.4 0.0 0.026 14.8 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.10 KII67485.1 - 0.021 15.0 0.1 0.079 13.2 0.1 2.1 1 0 0 1 1 1 0 H2C2 zinc finger Asp_protease_2 PF13650.6 KII67485.1 - 0.032 14.9 0.0 0.079 13.6 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease DDE_Tnp_IS1595 PF12762.7 KII67486.1 - 0.0001 22.3 0.0 0.031 14.3 0.0 2.1 2 0 0 2 2 2 2 ISXO2-like transposase domain DDE_3 PF13358.6 KII67486.1 - 0.0067 16.2 0.0 0.0099 15.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Serpin PF00079.20 KII67487.1 - 1.6e-42 146.2 4.1 1.8e-42 146.0 4.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII67488.1 - 4.3e-42 144.8 4.5 4.8e-42 144.6 4.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SOAR PF16533.5 KII67491.1 - 0.079 12.9 0.2 0.11 12.5 0.2 1.1 1 0 0 1 1 1 0 STIM1 Orai1-activating region RT_RNaseH_2 PF17919.1 KII67494.1 - 7.2e-37 125.4 0.1 1.3e-36 124.6 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67494.1 - 3.9e-36 123.5 0.0 7.4e-36 122.6 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67494.1 - 1.2e-20 74.0 0.1 2.5e-17 63.1 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII67494.1 - 2.6e-05 24.1 11.3 0.014 15.5 2.1 2.5 2 0 0 2 2 2 2 Zinc knuckle gag-asp_proteas PF13975.6 KII67494.1 - 4.8e-05 23.8 0.0 0.00011 22.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII67494.1 - 0.024 14.9 0.0 0.078 13.3 0.0 1.9 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 KII67494.1 - 0.032 14.0 7.6 1.4 8.8 0.6 2.8 1 1 1 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 KII67494.1 - 0.039 14.6 0.0 0.082 13.6 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Spuma_A9PTase PF03539.14 KII67494.1 - 0.046 13.9 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_6 PF15288.6 KII67494.1 - 0.094 12.6 11.8 0.59 10.0 0.8 2.5 2 0 0 2 2 2 0 Zinc knuckle RVP_2 PF08284.11 KII67494.1 - 0.13 12.1 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Ribosomal_L26 PF16906.5 KII67495.1 - 1.8e-32 111.6 8.5 2.8e-31 107.8 8.5 2.0 1 1 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal NMT1_3 PF16868.5 KII67495.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 NMT1-like family UAE_UbL PF14732.6 KII67496.1 - 0.015 15.8 0.2 0.037 14.6 0.1 1.8 2 0 0 2 2 2 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Beta-Casp PF10996.8 KII67498.1 - 2.1e-30 105.2 0.1 2.3e-28 98.7 0.0 2.4 2 0 0 2 2 2 1 Beta-Casp domain CPSF73-100_C PF11718.8 KII67498.1 - 6.3e-19 68.4 1.2 6.3e-18 65.1 1.1 2.3 2 1 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term RMMBL PF07521.12 KII67498.1 - 1.3e-10 41.1 0.0 3.2e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 KII67498.1 - 0.00013 21.4 0.0 0.00043 19.8 0.0 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain DUF2059 PF09832.9 KII67498.1 - 0.04 14.0 0.1 0.077 13.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2059) DRMBL PF07522.14 KII67498.1 - 0.086 13.0 0.0 0.23 11.7 0.0 1.8 1 1 0 1 1 1 0 DNA repair metallo-beta-lactamase FliG_C PF01706.16 KII67498.1 - 0.13 12.4 0.0 25 5.1 0.0 2.8 2 0 0 2 2 2 0 FliG C-terminal domain Reovirus_L2 PF06016.11 KII67498.1 - 0.14 9.3 0.0 0.23 8.6 0.0 1.2 1 0 0 1 1 1 0 Reovirus core-spike protein lambda-2 (L2) Glyco_hydro_2_C PF02836.17 KII67499.1 - 0.0072 15.5 0.1 0.027 13.6 0.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain DUF659 PF04937.15 KII67499.1 - 0.078 12.8 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Spore_III_AB PF09548.10 KII67499.1 - 0.085 13.0 0.1 0.13 12.4 0.1 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) MCR_beta_N PF02783.15 KII67499.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain Dimer_Tnp_hAT PF05699.14 KII67500.1 - 9.7e-05 22.1 0.8 0.00018 21.2 0.8 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Peptidase_M24 PF00557.24 KII67501.1 - 2.4e-19 69.9 0.1 3.7e-19 69.2 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 PLAC8 PF04749.17 KII67502.1 - 6.2e-09 36.8 7.8 7.1e-09 36.6 7.8 1.1 1 0 0 1 1 1 1 PLAC8 family MULE PF10551.9 KII67503.1 - 7.2e-15 55.2 0.0 1.4e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain Sortilin-Vps10 PF15902.5 KII67504.1 - 2.1e-06 26.8 3.3 0.00022 20.2 0.1 2.4 1 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII67504.1 - 1e-05 25.6 13.6 1e-05 25.6 13.6 3.6 3 1 0 3 3 3 1 Low-density lipoprotein receptor domain class A BNR_2 PF13088.6 KII67504.1 - 0.0084 15.4 0.0 0.03 13.6 0.0 1.8 2 0 0 2 2 2 1 BNR repeat-like domain zf-H3C2 PF16721.5 KII67504.1 - 0.012 16.0 0.6 0.044 14.1 0.3 2.2 1 1 1 2 2 2 0 Zinc-finger like, probable DNA-binding Sortilin-Vps10 PF15902.5 KII67505.1 - 2.8e-11 42.9 0.0 4.5e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII67505.1 - 1e-08 35.7 0.7 1.9e-08 34.8 0.7 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII67505.1 - 3.3e-05 23.3 0.6 0.91 9.8 0.0 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat MxiM PF11441.8 KII67505.1 - 0.08 13.2 0.1 0.08 13.2 0.1 2.4 3 1 0 3 3 3 0 Pilot protein MxiM Sortilin-Vps10 PF15902.5 KII67506.1 - 2e-07 30.2 0.2 4e-07 29.2 0.0 1.5 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII67506.1 - 0.00024 20.7 0.8 1.2 9.4 0.1 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_2 PF13088.6 KII67506.1 - 0.0049 16.2 0.0 0.0056 16.0 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain rve PF00665.26 KII67508.1 - 4e-18 65.7 0.0 5.1e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII67508.1 - 0.043 13.6 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain Sortilin_C PF15901.5 KII67510.1 - 2.3e-20 73.6 4.5 3.6e-20 73.0 4.5 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII67510.1 - 4.8e-12 45.4 0.6 7.1e-08 31.7 0.2 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII67510.1 - 3.1e-05 23.3 10.6 1.3 9.3 0.1 4.3 4 0 0 4 4 4 3 BNR/Asp-box repeat RVT_1 PF00078.27 KII67512.1 - 2.5e-07 30.4 0.0 3.4e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Folliculin_C PF16692.5 KII67514.1 - 0.048 13.4 0.1 0.063 13.0 0.1 1.2 1 0 0 1 1 1 0 Folliculin C-terminal domain Flavodoxin_2 PF02525.17 KII67515.1 - 1.8e-22 80.1 0.0 2e-22 79.9 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 KII67515.1 - 0.035 13.9 0.1 0.057 13.2 0.0 1.5 1 1 1 2 2 2 0 NADPH-dependent FMN reductase Rpn9_C PF18261.1 KII67515.1 - 0.12 11.9 0.1 0.19 11.3 0.1 1.2 1 0 0 1 1 1 0 Rpn9 C-terminal helix FragX_IP PF05994.11 KII67517.1 - 1.6e-96 324.3 5.6 2e-96 324.0 5.6 1.0 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family BALF1 PF06861.11 KII67518.1 - 0.057 13.1 0.2 0.091 12.4 0.2 1.3 1 0 0 1 1 1 0 BALF1 protein DUF5399 PF17377.2 KII67518.1 - 0.094 12.5 1.4 0.12 12.2 0.3 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5399) PGAP1 PF07819.13 KII67521.1 - 0.0062 16.3 0.2 0.014 15.1 0.1 1.7 1 1 1 2 2 2 1 PGAP1-like protein Serpin PF00079.20 KII67524.1 - 4e-32 111.9 4.9 4.7e-32 111.7 4.9 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) YoaP PF14268.6 KII67525.1 - 0.042 13.4 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 YoaP-like DDE_3 PF13358.6 KII67526.1 - 8.9e-20 70.9 0.0 1.1e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Transposase_1 PF01359.18 KII67526.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 Transposase (partial DDE domain) FXMR_C2 PF16098.5 KII67526.1 - 0.067 13.7 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 Fragile X-related mental retardation protein C-terminal region 2 DEAD PF00270.29 KII67527.1 - 7.7e-19 68.1 0.0 1.5e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KII67527.1 - 0.014 15.4 0.1 0.033 14.2 0.0 1.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF842 PF05811.13 KII67528.1 - 0.082 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) TERT_thumb PF17984.1 KII67528.1 - 0.11 12.4 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Telomerase reverse transcriptase thumb DNA binding domain 7tm_1 PF00001.21 KII67530.1 - 4.7e-25 88.4 20.2 6.9e-25 87.9 20.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KII67530.1 - 1.3e-09 37.8 16.8 1.3e-09 37.8 16.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx OSTbeta PF15048.6 KII67530.1 - 0.99 9.6 5.7 7.2 6.8 0.1 2.5 2 1 0 2 2 2 0 Organic solute transporter subunit beta protein DDE_3 PF13358.6 KII67533.1 - 0.038 13.8 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease Menin PF05053.13 KII67534.1 - 0.49 8.7 15.0 0.73 8.1 15.0 1.3 1 0 0 1 1 1 0 Menin LAP1C PF05609.12 KII67534.1 - 1.8 7.5 34.7 0.15 11.1 22.2 2.0 1 1 1 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) 7TM_GPCR_Srw PF10324.9 KII67536.1 - 0.00048 19.5 0.6 0.00054 19.3 0.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF1182 PF06681.13 KII67536.1 - 0.01 15.5 0.1 0.014 15.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1182) PgaPase_1 PF06162.12 KII67536.1 - 0.03 14.1 1.4 1.2 8.9 0.2 2.4 2 1 1 3 3 3 0 Putative pyroglutamyl peptidase PgaPase_1 KLRAQ PF10205.9 KII67537.1 - 4e-07 30.2 1.7 4e-07 30.2 1.7 3.7 2 2 2 4 4 4 1 Predicted coiled-coil domain-containing protein VGPC1_C PF16799.5 KII67537.1 - 0.5 10.4 7.3 2.8 8.0 7.3 2.4 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 ZapB PF06005.12 KII67537.1 - 1.3 9.5 22.0 4.4 7.8 0.6 4.4 3 1 1 4 4 4 0 Cell division protein ZapB DASH_Spc19 PF08287.11 KII67537.1 - 1.9 8.4 16.9 1 9.2 0.5 3.5 2 2 0 2 2 2 0 Spc19 TSC22 PF01166.18 KII67537.1 - 2.2 8.7 17.6 2.5 8.5 0.1 4.6 3 1 0 3 3 3 0 TSC-22/dip/bun family DUF4407 PF14362.6 KII67537.1 - 2.7 7.3 5.4 6.4 6.0 5.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) JIP_LZII PF16471.5 KII67537.1 - 3.8 7.8 17.8 2.3 8.4 1.7 5.4 3 2 1 4 4 4 0 JNK-interacting protein leucine zipper II TMF_TATA_bd PF12325.8 KII67537.1 - 5.6 7.2 19.0 10 6.4 7.6 3.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF5595 PF18077.1 KII67537.1 - 5.6 7.1 13.6 2.1 8.5 4.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) GIT_CC PF16559.5 KII67537.1 - 6.2 6.8 10.7 7.7 6.5 4.8 3.7 3 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor LIFR_D2 PF17971.1 KII67538.1 - 0.031 14.5 2.1 0.042 14.0 0.8 1.8 2 0 0 2 2 2 0 Leukemia inhibitory factor receptor D2 domain RT_RNaseH PF17917.1 KII67540.1 - 5.4e-37 126.3 0.0 9.9e-37 125.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII67540.1 - 3.4e-34 116.9 0.0 7.7e-34 115.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67540.1 - 3.3e-10 39.8 0.3 2.6e-09 36.9 0.1 2.1 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) REC1 PF18501.1 KII67540.1 - 0.076 12.9 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Alpha helical recognition lobe domain rve PF00665.26 KII67541.1 - 2.7e-13 50.1 0.0 6.3e-13 49.0 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII67541.1 - 0.00053 19.7 0.2 0.01 15.6 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Muted PF14942.6 KII67541.1 - 0.043 14.2 2.8 0.07 13.5 2.8 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein FliD_C PF07195.12 KII67541.1 - 0.054 12.9 4.2 0.14 11.5 4.2 1.7 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF4635 PF15466.6 KII67541.1 - 0.067 12.7 0.1 1.7 8.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) RT_RNaseH_2 PF17919.1 KII67542.1 - 1.3e-21 76.5 0.0 1.9e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67542.1 - 1.3e-11 44.4 0.1 2.1e-11 43.8 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII67542.1 - 2.6e-11 43.7 0.0 5.8e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII67543.1 - 5e-21 75.1 0.0 9.5e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67543.1 - 3.9e-19 68.5 0.1 3.9e-19 68.5 0.1 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII67543.1 - 0.00027 20.6 0.9 0.0015 18.3 0.6 2.4 1 1 0 1 1 1 1 Integrase core domain pEK499_p136 PF18736.1 KII67543.1 - 0.046 13.3 0.5 0.3 10.7 0.5 2.0 1 1 0 1 1 1 0 HEPN pEK499 p136 DDE_Tnp_IS240 PF13610.6 KII67543.1 - 0.08 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 DDE domain Myosin_N PF02736.19 KII67543.1 - 0.12 12.3 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain DDE_3 PF13358.6 KII67544.1 - 1.1e-21 77.2 0.0 3.1e-21 75.7 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease GerE PF00196.19 KII67544.1 - 0.00093 18.7 0.1 0.0021 17.6 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_Tnp_1 PF01527.20 KII67544.1 - 0.0019 18.4 0.1 0.0034 17.6 0.1 1.4 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 KII67544.1 - 0.012 15.4 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_10 PF04967.12 KII67544.1 - 0.055 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 HTH DNA binding domain HTH_5 PF01022.20 KII67544.1 - 0.08 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_Tnp_Tc3_2 PF01498.18 KII67544.1 - 0.085 13.1 0.1 0.24 11.7 0.1 1.8 1 0 0 1 1 1 0 Transposase HTH_28 PF13518.6 KII67544.1 - 0.13 12.4 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Arc_C PF18162.1 KII67545.1 - 0.03 14.2 0.0 0.063 13.1 0.0 1.6 2 0 0 2 2 2 0 Arc C-lobe RT_RNaseH_2 PF17919.1 KII67546.1 - 1.6e-34 117.9 0.0 8e-34 115.7 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67546.1 - 2.7e-34 118.6 0.1 5.5e-34 117.6 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII67546.1 - 1.2e-32 112.3 0.0 8.9e-32 109.5 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII67546.1 - 2.2e-20 73.0 0.0 7e-20 71.4 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67546.1 - 2.3e-18 66.1 0.4 6.7e-18 64.6 0.4 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII67546.1 - 8.6e-05 22.7 1.4 0.00073 19.7 0.0 2.8 3 0 0 3 3 3 1 H2C2 zinc finger rve_3 PF13683.6 KII67546.1 - 0.00017 21.3 0.2 0.0023 17.7 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.14 KII67546.1 - 0.0085 16.2 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) DUF2014 PF09427.10 KII67546.1 - 0.06 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) DDE_3 PF13358.6 KII67547.1 - 3.2e-15 56.2 0.1 1.3e-14 54.2 0.1 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease Colicin_Pyocin PF01320.18 KII67547.1 - 0.0095 16.0 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein DDE_3 PF13358.6 KII67548.1 - 0.062 13.0 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease zf-CCHC PF00098.23 KII67549.1 - 0.00095 19.1 0.9 0.0026 17.8 0.9 1.8 1 0 0 1 1 1 1 Zinc knuckle RVT_1 PF00078.27 KII67551.1 - 0.0085 15.6 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1147 PF06615.11 KII67551.1 - 0.19 11.8 1.1 0.43 10.6 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1147) MULE PF10551.9 KII67552.1 - 6.4e-12 45.7 0.1 1.2e-11 44.9 0.1 1.4 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.17 KII67552.1 - 0.19 11.4 0.3 0.37 10.5 0.0 1.5 2 0 0 2 2 2 0 Transposase gag-asp_proteas PF13975.6 KII67554.1 - 0.0027 18.2 0.0 0.0063 17.0 0.0 1.6 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII67554.1 - 0.042 14.5 0.1 0.12 13.1 0.0 1.9 2 1 0 2 2 2 0 Aspartyl protease rve PF00665.26 KII67555.1 - 6.7e-26 90.8 0.0 1.1e-25 90.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67555.1 - 1.4e-13 50.7 0.1 2.9e-13 49.7 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII67555.1 - 0.0028 17.4 0.0 0.049 13.4 0.0 2.7 1 1 1 2 2 2 1 Integrase core domain Serpin PF00079.20 KII67556.1 - 7.5e-42 144.0 4.9 8.4e-42 143.8 4.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DYW_deaminase PF14432.6 KII67560.1 - 0.058 13.3 0.0 0.079 12.8 0.0 1.3 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases DUF735 PF05246.11 KII67561.1 - 0.023 14.7 0.1 0.031 14.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF735) AMP-binding PF00501.28 KII67562.1 - 4.7e-76 256.1 0.0 6e-76 255.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KII67562.1 - 0.025 15.6 0.0 0.06 14.3 0.0 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 KII67563.1 - 1.7e-38 132.4 0.0 2.3e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Spermine_synth PF01564.17 KII67564.1 - 1.8e-30 105.8 1.3 3.9e-30 104.7 1.1 1.7 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KII67564.1 - 1.6e-10 40.7 0.3 2.1e-09 37.1 0.3 2.4 1 1 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KII67564.1 - 0.00032 21.4 0.0 0.00052 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII67564.1 - 0.061 14.0 0.0 0.11 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KII67564.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KII67564.1 - 0.14 13.0 0.0 0.23 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain HSP70 PF00012.20 KII67568.1 - 1.9e-101 340.1 0.0 2.7e-101 339.6 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KII67568.1 - 0.00028 19.8 0.0 0.00048 19.0 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.6 KII67568.1 - 0.037 14.4 0.0 0.17 12.3 0.0 2.1 1 1 0 1 1 1 0 Cell division protein FtsA TFIIB PF00382.19 KII67569.1 - 5.6e-06 26.3 0.0 1.4e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Transcription factor TFIIB repeat BRF1 PF07741.13 KII67569.1 - 2.5e-05 24.5 0.2 0.00011 22.5 0.2 2.0 1 0 0 1 1 1 1 Brf1-like TBP-binding domain AT_hook PF02178.19 KII67569.1 - 0.14 12.1 6.7 0.48 10.5 6.7 1.9 1 0 0 1 1 1 0 AT hook motif DDE_Tnp_IS1595 PF12762.7 KII67571.1 - 0.00027 21.0 0.0 0.00089 19.3 0.0 1.6 1 1 1 2 2 2 1 ISXO2-like transposase domain NFACT-R_1 PF05670.13 KII67571.1 - 0.14 12.8 0.0 0.23 12.1 0.0 1.3 1 0 0 1 1 1 0 NFACT protein RNA binding domain CAP18_C PF12153.8 KII67572.1 - 2.4 8.1 11.1 1.6 8.6 2.1 3.0 1 1 1 2 2 2 0 LPS binding domain of CAP18 (C terminal) Cauli_VI PF01693.16 KII67573.1 - 0.097 13.0 0.5 2.3 8.6 0.0 2.5 2 0 0 2 2 2 0 Caulimovirus viroplasmin FerB PF08150.12 KII67573.1 - 0.1 13.2 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 FerB (NUC096) domain DNA_pol_B PF00136.21 KII67574.1 - 1e-05 24.5 0.2 1.6e-05 23.8 0.0 1.3 2 0 0 2 2 2 1 DNA polymerase family B Sas6_CC PF18594.1 KII67574.1 - 0.027 14.2 0.6 0.059 13.2 0.6 1.5 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain FLYWCH PF04500.16 KII67577.1 - 0.0012 18.9 2.9 0.0026 17.9 2.9 1.6 1 1 0 1 1 1 1 FLYWCH zinc finger domain Porphobil_deam PF01379.20 KII67579.1 - 1.9e-28 99.4 0.0 3.1e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 KII67579.1 - 1.4e-11 44.6 0.3 3.1e-11 43.5 0.1 1.7 2 0 0 2 2 2 1 Porphobilinogen deaminase, C-terminal domain PLAC8 PF04749.17 KII67580.1 - 1.5e-16 61.2 14.9 2.1e-16 60.7 14.9 1.2 1 0 0 1 1 1 1 PLAC8 family Methyltransf_8 PF05148.15 KII67581.1 - 3.6e-70 236.2 0.2 4.4e-70 236.0 0.2 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 KII67581.1 - 1.4e-05 25.7 0.0 0.00014 22.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KII67581.1 - 3.4e-05 24.5 0.0 0.057 14.1 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 KII67581.1 - 0.0052 16.4 0.0 0.073 12.6 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase small domain BSD PF03909.17 KII67581.1 - 0.0097 15.9 0.5 4.4 7.4 0.1 2.5 2 0 0 2 2 2 2 BSD domain Methyltransf_31 PF13847.6 KII67581.1 - 0.037 13.8 0.0 2 8.2 0.0 2.3 1 1 1 2 2 2 0 Methyltransferase domain GCN5L1 PF06320.13 KII67581.1 - 0.054 13.6 0.1 0.097 12.8 0.1 1.4 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) zf-C5HC2 PF02928.16 KII67583.1 - 0.0056 17.0 0.2 0.0089 16.4 0.2 1.3 1 0 0 1 1 1 1 C5HC2 zinc finger RNA_pol_Rpb4 PF03874.16 KII67583.1 - 0.089 13.1 2.7 0.17 12.2 2.7 1.6 1 1 0 1 1 1 0 RNA polymerase Rpb4 DUF508 PF04370.12 KII67583.1 - 0.11 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF508) GP11 PF08677.10 KII67583.1 - 0.21 11.0 0.0 0.22 11.0 0.0 1.1 1 0 0 1 1 1 0 GP11 baseplate wedge protein Herpes_UL52 PF03121.15 KII67584.1 - 4.4e-10 39.3 1.4 1.5e-09 37.7 1.4 1.9 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase DUF5358 PF17311.2 KII67584.1 - 0.026 14.5 0.4 0.057 13.4 0.2 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5358) Pkinase PF00069.25 KII67585.1 - 1.2e-11 44.5 0.0 1.5e-09 37.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain EcKinase PF02958.20 KII67585.1 - 0.0017 17.7 0.0 0.0066 15.8 0.1 1.7 2 0 0 2 2 2 1 Ecdysteroid kinase Pkinase_Tyr PF07714.17 KII67585.1 - 0.016 14.5 0.1 0.18 11.1 0.1 2.0 1 1 0 1 1 1 0 Protein tyrosine kinase Far-17a_AIG1 PF04750.14 KII67586.1 - 2e-23 82.8 12.3 2.8e-23 82.3 12.3 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Cytochrome-c551 PF10643.9 KII67586.1 - 5.3 6.6 8.2 1.6 8.3 0.7 2.1 1 1 1 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 Laminin_G_3 PF13385.6 KII67588.1 - 1.4e-24 87.0 0.0 4.2e-11 43.2 0.0 4.1 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily Kunitz_BPTI PF00014.23 KII67588.1 - 3.7e-16 59.1 0.8 9.8e-16 57.7 0.8 1.8 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain CBM_14 PF01607.24 KII67588.1 - 1.2e-08 34.9 0.2 4.7e-08 33.1 0.2 2.0 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain TSP_1 PF00090.19 KII67588.1 - 0.002 18.3 7.2 0.0028 17.9 4.6 2.6 2 0 0 2 2 2 1 Thrombospondin type 1 domain Laminin_G_2 PF02210.24 KII67588.1 - 0.0064 17.1 0.1 0.12 12.9 0.0 2.8 2 0 0 2 2 2 1 Laminin G domain DDE_3 PF13358.6 KII67589.1 - 1.4e-05 24.9 0.0 2.7e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease PPR PF01535.20 KII67589.1 - 0.1 12.9 0.2 19 5.8 0.0 2.5 2 0 0 2 2 2 0 PPR repeat Mito_carr PF00153.27 KII67591.1 - 9.5e-62 205.0 2.6 2.3e-21 75.5 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein DegS PF05384.11 KII67592.1 - 0.0052 16.3 2.0 0.026 14.0 0.3 2.0 1 1 1 2 2 2 1 Sensor protein DegS FapA PF03961.13 KII67592.1 - 0.022 13.4 0.3 0.025 13.2 0.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2312 PF10073.9 KII67592.1 - 0.076 12.7 0.2 0.17 11.6 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) HMMR_N PF15905.5 KII67592.1 - 0.093 12.2 2.0 0.097 12.1 2.0 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DprA_WH PF17782.1 KII67592.1 - 0.16 12.1 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 DprA winged helix domain Pox_D5 PF03288.16 KII67593.1 - 0.067 13.7 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 Poxvirus D5 protein-like SIS PF01380.22 KII67594.1 - 1.1e-49 167.7 0.6 3.3e-29 101.4 0.1 2.6 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KII67594.1 - 5.7e-13 49.2 0.0 1.1e-12 48.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KII67594.1 - 2.9e-08 33.6 0.0 6.6e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KII67594.1 - 0.00045 19.2 0.0 0.00079 18.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 KII67594.1 - 0.047 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 SIS domain Transglut_N PF00868.20 KII67597.1 - 7.9e-06 26.2 0.0 1.3e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase family GCK PF07802.11 KII67599.1 - 0.04 14.3 0.7 5.5 7.5 0.1 2.5 2 0 0 2 2 2 0 GCK domain Glyco_transf_10 PF00852.19 KII67601.1 - 8.3e-41 139.6 6.1 9.8e-41 139.4 6.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term rRNA_methylase PF06962.12 KII67604.1 - 0.091 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative rRNA methylase CHASE9 PF17153.4 KII67604.1 - 0.13 12.4 2.2 9.4 6.4 0.1 2.1 1 1 1 2 2 2 0 Periplasmic sensor domain, extracellular PWI PF01480.17 KII67605.1 - 2.6e-26 91.7 0.1 7.9e-26 90.2 0.0 1.8 2 0 0 2 2 2 1 PWI domain Tyr_Deacylase PF02580.16 KII67606.1 - 4.7e-38 130.9 0.1 5.3e-38 130.8 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Streptin-Immun PF11083.8 KII67606.1 - 0.059 13.8 0.4 0.091 13.2 0.4 1.2 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein RrnaAD PF00398.20 KII67608.1 - 8.1e-62 208.7 0.0 1.1e-61 208.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 KII67608.1 - 7.4e-09 36.2 0.0 1.3e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII67608.1 - 1.2e-06 29.0 0.0 2.5e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KII67608.1 - 9.2e-06 26.3 0.0 1.8e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KII67608.1 - 0.0003 20.6 0.0 0.00045 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KII67608.1 - 0.0003 20.4 0.0 0.0005 19.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 KII67608.1 - 0.00049 19.5 0.0 0.00068 19.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KII67608.1 - 0.0012 18.7 0.0 0.0014 18.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 KII67608.1 - 0.0027 17.4 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_4 PF02390.17 KII67608.1 - 0.0087 15.5 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 KII67608.1 - 0.012 15.4 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 KII67608.1 - 0.047 12.8 0.0 0.067 12.3 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase TrkA_N PF02254.18 KII67608.1 - 0.052 13.8 0.0 0.092 13.0 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Spermine_synth PF01564.17 KII67608.1 - 0.091 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase domain DUF43 PF01861.16 KII67608.1 - 0.14 11.4 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_28 PF02636.17 KII67608.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PhrC_PhrF PF11131.8 KII67609.1 - 0.074 12.7 1.2 0.74 9.5 0.0 2.3 2 0 0 2 2 2 0 Rap-phr extracellular signalling DUF4134 PF13572.6 KII67609.1 - 0.17 12.2 3.8 4.2 7.7 4.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4134) DUF3989 PF13150.6 KII67609.1 - 1.1 9.0 8.1 0.82 9.4 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3989) Pkinase PF00069.25 KII67610.1 - 1e-49 169.3 0.0 1.3e-49 168.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII67610.1 - 2.9e-23 82.5 0.0 4.8e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII67610.1 - 0.00018 20.9 0.0 0.00057 19.3 0.0 1.6 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 KII67610.1 - 0.0045 16.9 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Actin PF00022.19 KII67611.1 - 5.4e-91 305.2 0.0 3.7e-59 200.3 0.0 2.3 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 KII67611.1 - 0.023 13.5 1.5 0.49 9.2 0.0 2.8 3 0 0 3 3 3 0 MreB/Mbl protein DDE_3 PF13358.6 KII67612.1 - 0.0001 22.1 0.7 0.00014 21.7 0.6 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF3502 PF12010.8 KII67615.1 - 0.22 12.1 1.2 0.37 11.4 0.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3502) ATP-synt_E_2 PF08112.11 KII67615.1 - 1.8 8.9 8.2 2.2 8.6 0.7 3.2 2 2 0 2 2 2 0 ATP synthase epsilon subunit CLTH PF10607.9 KII67616.1 - 0.046 13.6 4.2 0.48 10.3 0.4 2.3 2 0 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain DUF2397 PF09660.10 KII67618.1 - 0.046 12.6 0.0 0.091 11.7 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2397) Sec8_exocyst PF04048.14 KII67618.1 - 0.13 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF4805 PF16063.5 KII67620.1 - 0.014 14.8 0.0 0.016 14.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) DUF4224 PF13986.6 KII67627.1 - 0.41 10.6 0.9 1.4e+02 2.5 0.0 3.8 1 1 4 5 5 5 0 Domain of unknown function (DUF4224) Plasmodium_HRP PF05403.11 KII67627.1 - 6.5 6.5 33.4 8.8 6.1 33.4 1.2 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) Vps51 PF08700.11 KII67629.1 - 0.045 13.8 5.0 0.051 13.7 2.6 2.3 2 1 0 2 2 2 0 Vps51/Vps67 DUF16 PF01519.16 KII67629.1 - 2.6 8.6 8.6 1.1 9.8 4.4 2.6 2 1 1 3 3 3 0 Protein of unknown function DUF16 PilX PF13681.6 KII67630.1 - 0.029 14.7 0.0 0.034 14.5 0.0 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilX C-term DDE_3 PF13358.6 KII67632.1 - 8.4e-05 22.4 0.0 0.0001 22.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Ndr PF03096.14 KII67633.1 - 9.6e-14 50.7 0.0 1.2e-13 50.5 0.0 1.0 1 0 0 1 1 1 1 Ndr family Prenyltrans PF00432.21 KII67634.1 - 1.8e-38 129.9 5.9 5.8e-12 45.1 0.2 4.0 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat LEF-8 PF04941.12 KII67634.1 - 0.07 11.4 0.2 0.087 11.1 0.2 1.1 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) Calx-beta PF03160.14 KII67636.1 - 0.057 13.6 0.1 0.099 12.8 0.1 1.5 1 1 0 1 1 1 0 Calx-beta domain RRM_1 PF00076.22 KII67638.1 - 1.9e-07 30.8 0.0 0.027 14.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_3 PF01494.19 KII67639.1 - 0.0056 16.0 0.0 0.0074 15.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 KII67639.1 - 0.0079 15.5 0.0 0.0099 15.1 0.0 1.1 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 KII67639.1 - 0.012 14.8 0.0 0.012 14.8 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase JAB PF01398.21 KII67639.1 - 0.02 14.8 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease NAD_binding_9 PF13454.6 KII67639.1 - 0.023 14.7 0.2 0.066 13.2 0.1 1.7 1 1 1 2 2 2 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 KII67639.1 - 0.028 14.6 0.0 0.055 13.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF4516 PF14990.6 KII67639.1 - 0.077 12.7 0.1 10 5.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4516) Pyr_redox_3 PF13738.6 KII67639.1 - 0.082 12.1 0.0 0.091 12.0 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KII67639.1 - 0.091 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 KII67639.1 - 0.091 12.3 0.0 0.096 12.2 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase LUC7 PF03194.15 KII67640.1 - 5.4e-70 235.9 10.3 8.9e-70 235.2 9.6 1.7 1 1 1 2 2 2 1 LUC7 N_terminus Prominin PF05478.11 KII67640.1 - 0.0004 18.5 0.1 0.00055 18.1 0.1 1.1 1 0 0 1 1 1 1 Prominin DUF4551 PF15087.6 KII67640.1 - 1.1 8.0 14.5 1.7 7.4 14.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) 3HCDH_N PF02737.18 KII67641.1 - 1.3e-38 132.6 0.0 2e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KII67641.1 - 7.6e-26 90.6 0.0 1.3e-15 57.8 0.0 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 KII67641.1 - 7.3e-19 68.4 0.0 9.9e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KII67641.1 - 2.5e-17 63.0 0.0 7.1e-17 61.6 0.0 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Semialdhyde_dh PF01118.24 KII67641.1 - 0.0012 19.3 0.1 0.01 16.3 0.0 2.4 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain HbrB PF08539.11 KII67642.1 - 0.0029 17.6 0.1 0.0039 17.2 0.1 1.3 1 0 0 1 1 1 1 HbrB-like YscK PF06578.12 KII67642.1 - 0.057 12.9 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) KA1 PF02149.19 KII67643.1 - 0.12 12.1 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 Kinase associated domain 1 Pkinase PF00069.25 KII67644.1 - 5.1e-36 124.4 0.0 5.7e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII67644.1 - 3.8e-20 72.3 0.0 4.6e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII67644.1 - 4.6e-07 29.4 0.0 5.9e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KII67644.1 - 0.00028 20.6 0.0 0.00034 20.3 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KII67644.1 - 0.0031 17.5 0.0 0.0042 17.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KII67644.1 - 0.014 14.3 0.2 0.019 14.0 0.2 1.1 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 KII67644.1 - 0.023 14.3 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KII67644.1 - 0.047 13.0 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KII67644.1 - 0.15 10.8 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase DDE_3 PF13358.6 KII67649.1 - 1.9e-13 50.4 0.0 3.7e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII67649.1 - 0.0005 19.8 0.0 0.004 16.9 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 KII67649.1 - 0.0008 19.0 0.0 0.0018 17.9 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_33 PF13592.6 KII67649.1 - 0.0014 18.2 0.1 0.004 16.8 0.1 1.7 1 0 0 1 1 1 1 Winged helix-turn helix Sigma70_r4 PF04545.16 KII67649.1 - 0.013 15.0 0.0 0.032 13.8 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_24 PF13412.6 KII67649.1 - 0.028 14.0 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding CRIC_ras_sig PF10534.9 KII67649.1 - 0.029 14.5 0.0 0.066 13.4 0.0 1.5 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras MarR_2 PF12802.7 KII67649.1 - 0.11 12.4 0.0 0.36 10.8 0.0 1.8 1 1 1 2 2 2 0 MarR family RRM_1 PF00076.22 KII67651.1 - 2.7e-14 52.7 0.0 3.6e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDE_Tnp_IS1595 PF12762.7 KII67652.1 - 0.04 13.9 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 ISXO2-like transposase domain RB_B PF01857.20 KII67653.1 - 3.4e-34 117.7 3.1 1.3e-33 115.8 3.1 2.1 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain RB_A PF01858.17 KII67653.1 - 1.8e-28 99.8 4.6 1.8e-28 99.8 4.6 4.2 3 2 0 3 3 3 1 Retinoblastoma-associated protein A domain DUF3452 PF11934.8 KII67653.1 - 8.1e-19 67.5 5.2 8.1e-19 67.5 5.2 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3452) DUF3091 PF11291.8 KII67653.1 - 0.0063 16.7 0.3 0.053 13.7 0.3 2.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3091) Cofilin_ADF PF00241.20 KII67654.1 - 9.2e-17 61.0 0.0 1e-16 60.8 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ANAPC4_WD40 PF12894.7 KII67655.1 - 1.2e-06 28.7 0.0 0.026 14.8 0.0 4.3 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KII67655.1 - 0.00014 21.3 0.8 0.075 12.3 0.0 3.1 2 1 1 3 3 3 2 WD40-like domain DUF4221 PF13970.6 KII67655.1 - 0.017 14.7 0.6 0.15 11.6 0.1 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4221) WD40 PF00400.32 KII67655.1 - 0.033 15.1 0.2 25 6.0 0.0 4.6 6 0 0 6 6 6 0 WD domain, G-beta repeat Pkinase_C PF00433.24 KII67656.1 - 0.0007 20.2 0.1 0.0012 19.5 0.1 1.4 1 0 0 1 1 1 1 Protein kinase C terminal domain Pkinase PF00069.25 KII67656.1 - 0.002 17.5 0.0 0.0025 17.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain UPF0254 PF06787.11 KII67656.1 - 0.14 11.9 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) RRM_1 PF00076.22 KII67657.1 - 2.3e-14 52.9 0.2 3.9e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII67657.1 - 0.0046 17.0 0.0 0.086 13.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif PhetRS_B1 PF18262.1 KII67657.1 - 0.057 13.6 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain RL PF17797.1 KII67657.1 - 0.069 13.1 0.0 0.72 9.8 0.0 2.2 2 0 0 2 2 2 0 RL domain CDC48_2 PF02933.17 KII67658.1 - 0.091 12.6 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 MULE PF10551.9 KII67659.1 - 9.2e-06 26.0 0.0 1.4e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 MULE transposase domain V-ATPase_H_N PF03224.14 KII67660.1 - 8e-07 28.6 0.8 8.8e-07 28.5 0.8 1.0 1 0 0 1 1 1 1 V-ATPase subunit H HLH PF00010.26 KII67662.1 - 1.8e-09 37.4 2.1 3.3e-09 36.6 2.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_3 PF08447.12 KII67662.1 - 1e-08 35.4 0.0 4.4e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 KII67662.1 - 0.0057 16.6 0.0 0.048 13.7 0.0 2.5 3 0 0 3 3 3 1 PAS fold HTH_Tnp_Tc3_2 PF01498.18 KII67664.1 - 8.6e-08 32.3 0.0 1.7e-05 25.0 0.0 2.3 2 0 0 2 2 2 2 Transposase HTH_33 PF13592.6 KII67664.1 - 0.01 15.5 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HTH_24 PF13412.6 KII67664.1 - 0.03 13.9 3.8 0.064 12.8 0.0 2.5 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding PIF1 PF05970.14 KII67665.1 - 4.4e-31 108.3 0.5 1.1e-30 107.0 0.5 1.6 1 1 0 1 1 1 1 PIF1-like helicase Glyco_hydro_47 PF01532.20 KII67666.1 - 5.2e-25 88.3 0.0 6e-25 88.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DDE_Tnp_IS1595 PF12762.7 KII67667.1 - 0.098 12.7 0.0 0.75 9.8 0.0 2.0 1 1 1 2 2 2 0 ISXO2-like transposase domain HTH_DeoR PF08220.12 KII67668.1 - 0.0049 16.6 0.5 0.0075 16.0 0.5 1.3 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII67668.1 - 0.0063 16.7 0.9 0.009 16.2 0.9 1.2 1 0 0 1 1 1 1 Transposase RL10P_insert PF17777.1 KII67668.1 - 0.079 13.0 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Insertion domain in 60S ribosomal protein L10P Thiolase_C PF02803.18 KII67669.1 - 1.2e-26 92.7 0.0 2e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain Thiolase_N PF00108.23 KII67669.1 - 1.9e-15 56.9 0.2 5.1e-15 55.6 0.2 1.7 1 1 0 1 1 1 1 Thiolase, N-terminal domain Glycoprotein_B PF00606.18 KII67669.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B ectodomain Thiolase_C PF02803.18 KII67670.1 - 3.1e-18 65.6 0.0 4.7e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Thiolase, C-terminal domain Thiolase_N PF00108.23 KII67670.1 - 1.4e-11 44.2 1.4 7.3e-11 41.9 0.1 2.2 3 0 0 3 3 3 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.26 KII67670.1 - 4.5e-05 23.1 0.2 9.7e-05 22.1 0.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KII67670.1 - 0.0008 19.2 0.1 0.014 15.2 0.1 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACT_6 PF13740.6 KII67670.1 - 0.0048 16.8 0.0 0.0088 16.0 0.0 1.4 1 0 0 1 1 1 1 ACT domain DUF1604 PF07713.13 KII67671.1 - 1.2e-33 114.7 2.4 1.2e-33 114.7 2.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.23 KII67671.1 - 3.3e-05 23.7 0.8 9.2e-05 22.3 0.1 2.2 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 KII67671.1 - 0.0069 16.5 0.1 0.044 13.9 0.1 2.4 1 1 0 1 1 1 1 G-patch domain HlyU PF10115.9 KII67671.1 - 0.042 13.9 0.1 0.12 12.4 0.1 1.8 1 0 0 1 1 1 0 Transcriptional activator HlyU CH PF00307.31 KII67672.1 - 3.3e-45 152.7 2.1 1e-21 77.2 0.2 3.3 3 0 0 3 3 3 3 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KII67672.1 - 8.6e-13 47.9 1.3 0.0028 17.4 0.2 3.6 3 0 0 3 3 3 3 CAMSAP CH domain Filamin PF00630.19 KII67672.1 - 0.00037 21.3 0.0 0.00091 20.0 0.0 1.7 1 0 0 1 1 1 1 Filamin/ABP280 repeat CH_2 PF06294.11 KII67672.1 - 0.071 13.2 0.0 10 6.3 0.0 3.0 3 0 0 3 3 3 0 CH-like domain in sperm protein Filamin PF00630.19 KII67673.1 - 1.6e-26 93.1 3.0 2.5e-08 34.7 0.0 4.2 4 0 0 4 4 4 4 Filamin/ABP280 repeat PepSY PF03413.19 KII67673.1 - 0.29 11.7 2.1 12 6.6 0.7 3.5 2 1 0 2 2 2 0 Peptidase propeptide and YPEB domain RCC1 PF00415.18 KII67674.1 - 1.3e-10 41.7 0.1 0.00064 20.3 0.1 2.7 2 1 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KII67674.1 - 2.8e-06 27.0 0.1 0.00099 18.8 0.0 3.2 2 1 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KII67675.1 - 4e-08 32.8 3.6 0.0057 16.4 0.0 3.1 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 KII67675.1 - 4.4e-08 33.6 4.4 0.0032 18.1 1.7 3.1 2 1 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat Mur_ligase_M PF08245.12 KII67676.1 - 1.7e-10 41.2 0.4 4.4e-10 39.9 0.4 1.6 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 KII67676.1 - 0.12 12.7 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain TMF_DNA_bd PF12329.8 KII67678.1 - 0.01 15.8 0.8 0.017 15.1 0.8 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 KII67678.1 - 0.036 14.1 2.2 0.046 13.8 1.9 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Acetyltransf_4 PF13420.7 KII67678.1 - 0.047 13.8 0.3 0.69 10.0 0.1 2.0 1 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Cnn_1N PF07989.11 KII67678.1 - 0.056 13.6 1.7 0.088 13.0 0.2 2.0 1 1 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF4606 PF15379.6 KII67678.1 - 0.084 13.1 0.5 0.16 12.2 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4606) DUF1077 PF06417.12 KII67679.1 - 7e-25 87.3 0.2 8.3e-25 87.1 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) SPC25 PF06703.11 KII67682.1 - 9e-20 71.1 0.1 1e-19 70.9 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Herpes_LMP1 PF05297.11 KII67682.1 - 3.5 6.7 6.6 4.5 6.4 6.6 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) CBM_21 PF03370.13 KII67687.1 - 8.1e-25 87.2 3.8 1.3e-24 86.6 3.8 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KII67687.1 - 2.9e-10 40.6 2.5 5e-10 39.8 2.5 1.3 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) DUF1854 PF08909.11 KII67687.1 - 0.043 13.6 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1854) MAM33 PF02330.16 KII67688.1 - 2.6e-13 50.4 0.1 4.2e-12 46.5 0.1 2.2 1 1 0 1 1 1 1 Mitochondrial glycoprotein DUF1653 PF07866.11 KII67688.1 - 0.024 14.9 0.1 16 5.9 0.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1653) DUF2880 PF11082.8 KII67688.1 - 0.1 13.0 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2880) Phage_TAC_13 PF16459.5 KII67688.1 - 0.12 12.8 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone, TAC Amastin PF07344.11 KII67689.1 - 0.49 10.2 6.5 0.68 9.8 6.0 1.5 1 1 0 1 1 1 0 Amastin surface glycoprotein MARVEL PF01284.23 KII67689.1 - 2.8 8.0 12.9 18 5.4 10.8 2.1 1 1 1 2 2 2 0 Membrane-associating domain SNARE PF05739.19 KII67690.1 - 2.6e-13 49.7 2.6 7.9e-13 48.2 2.6 1.9 1 1 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 KII67690.1 - 4.2e-06 26.6 10.9 4.2e-06 26.6 10.9 2.5 2 1 0 2 2 2 1 Syntaxin Syntaxin_2 PF14523.6 KII67690.1 - 0.00095 19.5 8.3 0.0021 18.4 0.9 2.5 2 1 0 2 2 2 1 Syntaxin-like protein Phospholamban PF04272.14 KII67690.1 - 0.014 14.9 1.4 0.032 13.7 1.4 1.6 1 0 0 1 1 1 0 Phospholamban DUF16 PF01519.16 KII67690.1 - 0.016 15.7 2.2 0.016 15.7 2.2 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 TBCA PF02970.16 KII67690.1 - 0.019 15.3 1.3 0.019 15.3 1.3 2.3 1 1 1 2 2 2 0 Tubulin binding cofactor A CLCA PF08434.11 KII67690.1 - 0.019 14.3 1.9 1.4 8.2 0.4 2.1 2 0 0 2 2 2 0 Calcium-activated chloride channel N terminal RIFIN PF02009.16 KII67690.1 - 0.023 14.6 5.2 0.03 14.2 5.2 1.1 1 0 0 1 1 1 0 Rifin SKA1 PF07160.12 KII67690.1 - 0.025 14.4 1.4 0.025 14.4 1.4 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 SieB PF14163.6 KII67690.1 - 0.035 13.6 4.7 0.42 10.1 0.2 2.3 2 0 0 2 2 2 0 Super-infection exclusion protein B MCPsignal PF00015.21 KII67690.1 - 0.043 13.6 5.4 0.05 13.4 3.1 1.9 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TMCO5 PF14992.6 KII67690.1 - 0.058 13.0 11.5 1.7 8.2 11.5 2.6 1 1 0 1 1 1 0 TMCO5 family DUF805 PF05656.14 KII67690.1 - 0.065 13.7 0.8 0.096 13.1 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) AIP3 PF03915.13 KII67690.1 - 0.076 12.1 9.1 0.1 11.7 9.1 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Vac_Fusion PF02346.16 KII67690.1 - 0.11 12.2 2.9 2.2 7.9 0.2 2.4 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 ABC_tran_CTD PF16326.5 KII67690.1 - 0.11 12.8 0.2 0.11 12.8 0.2 2.7 2 1 2 4 4 4 0 ABC transporter C-terminal domain Laminin_II PF06009.12 KII67690.1 - 0.12 12.4 5.0 0.22 11.5 0.8 2.1 2 0 0 2 2 2 0 Laminin Domain II Orf78 PF06024.12 KII67690.1 - 0.16 12.3 1.8 0.17 12.2 0.4 1.8 1 1 1 2 2 2 0 Orf78 (ac78) LMBR1 PF04791.16 KII67690.1 - 0.39 9.6 4.2 0.53 9.1 4.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DASH_Duo1 PF08651.10 KII67690.1 - 0.9 9.4 6.4 7.4 6.4 0.3 3.1 2 2 1 3 3 3 0 DASH complex subunit Duo1 CREPT PF16566.5 KII67690.1 - 1.3 9.2 8.0 2.7 8.2 0.9 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Synaptobrevin PF00957.21 KII67690.1 - 1.4 8.8 12.3 0.13 12.1 6.9 2.0 2 2 0 2 2 2 0 Synaptobrevin DHR10 PF18595.1 KII67690.1 - 1.8 8.7 12.5 0.43 10.6 3.5 2.7 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain Mt_ATP-synt_D PF05873.12 KII67690.1 - 2.6 7.9 7.9 4.3 7.2 0.3 2.1 1 1 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) SlyX PF04102.12 KII67690.1 - 3.6 8.3 7.4 0.44 11.2 0.9 2.4 3 0 0 3 3 2 0 SlyX FliJ PF02050.16 KII67690.1 - 3.8 7.7 11.2 4.7 7.5 4.8 2.3 1 1 1 2 2 2 0 Flagellar FliJ protein Tweety PF04906.13 KII67690.1 - 5.1 5.6 7.8 36 2.9 7.6 2.0 1 1 0 1 1 1 0 Tweety Fib_alpha PF08702.10 KII67690.1 - 7.7 6.7 10.0 8.4 6.6 8.2 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FF PF01846.19 KII67691.1 - 4.8e-26 90.7 25.5 4.9e-09 36.2 0.0 6.7 8 0 0 8 8 8 5 FF domain DUF2431 PF10354.9 KII67691.1 - 0.025 14.9 0.1 0.14 12.4 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2431) UPF0175 PF03683.13 KII67691.1 - 0.068 12.9 0.4 0.21 11.3 0.4 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0175) FLYWCH PF04500.16 KII67692.1 - 6.7e-13 48.5 4.2 1.3e-12 47.6 3.3 1.9 2 0 0 2 2 2 1 FLYWCH zinc finger domain Usp PF00582.26 KII67696.1 - 1e-10 42.3 0.0 3.2e-10 40.7 0.0 1.7 1 1 0 1 1 1 1 Universal stress protein family Vps26 PF03643.15 KII67697.1 - 3e-38 131.4 1.8 3.9e-38 131.0 1.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 HEPPP_synt_1 PF07307.11 KII67698.1 - 0.0031 17.2 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 MAPKK1_Int PF08923.10 KII67698.1 - 0.03 14.1 0.2 0.07 12.9 0.2 1.6 1 0 0 1 1 1 0 Mitogen-activated protein kinase kinase 1 interacting Dimer_Tnp_hAT PF05699.14 KII67700.1 - 2.7e-08 33.5 0.1 5.3e-08 32.5 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region LAT2 PF15703.5 KII67700.1 - 0.0093 15.9 0.2 0.015 15.2 0.2 1.3 1 0 0 1 1 1 1 Linker for activation of T-cells family member 2 Col_cuticle_N PF01484.17 KII67701.1 - 4.5 7.4 6.2 1.6 8.8 0.3 2.3 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain Ras PF00071.22 KII67702.1 - 6e-59 198.3 0.1 7e-59 198.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII67702.1 - 4.1e-33 114.1 0.0 6e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII67702.1 - 4.9e-15 55.4 0.0 5.7e-15 55.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII67702.1 - 1.1e-05 24.9 0.0 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KII67702.1 - 0.00014 21.9 0.0 0.00022 21.3 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KII67702.1 - 0.00031 20.7 0.1 0.41 10.5 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KII67702.1 - 0.0014 18.2 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain CPT PF07931.12 KII67702.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 KII67702.1 - 0.013 15.9 0.1 0.02 15.3 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 KII67702.1 - 0.041 13.0 0.1 0.37 9.9 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit TniB PF05621.11 KII67702.1 - 0.046 13.1 0.0 0.075 12.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Phage_holin_2_4 PF16082.5 KII67702.1 - 0.16 11.7 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like gag-asp_proteas PF13975.6 KII67703.1 - 0.0014 19.2 0.0 0.0027 18.2 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII67703.1 - 0.0017 18.7 0.0 0.0034 17.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII67703.1 - 0.014 16.0 0.0 0.03 15.0 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease rve PF00665.26 KII67704.1 - 4.4e-15 55.9 0.1 6.1e-15 55.5 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67704.1 - 5e-05 23.3 1.3 5e-05 23.3 1.3 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII67704.1 - 0.063 13.1 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Peptidase_C1 PF00112.23 KII67705.1 - 1.6e-27 97.0 0.3 2.8e-27 96.2 0.3 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII67705.1 - 1.5e-11 44.5 5.2 2.4e-11 43.9 5.2 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) HTH_32 PF13565.6 KII67706.1 - 1.4e-06 28.9 0.1 0.00068 20.2 0.0 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII67706.1 - 2e-06 27.9 0.2 1.1e-05 25.6 0.0 2.2 2 1 1 3 3 3 1 Transposase HTH_23 PF13384.6 KII67706.1 - 9.8e-06 25.2 0.2 7.7e-05 22.4 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 KII67706.1 - 0.00035 20.2 0.0 0.0012 18.5 0.0 2.0 1 1 1 2 2 2 1 Winged helix-turn helix HTH_24 PF13412.6 KII67706.1 - 0.0015 18.0 1.9 0.22 11.1 0.0 3.3 4 0 0 4 4 4 1 Winged helix-turn-helix DNA-binding HTH_Tnp_1 PF01527.20 KII67706.1 - 0.0021 18.3 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 Transposase Phage_RpbA PF10789.9 KII67706.1 - 0.011 15.8 0.2 0.02 15.0 0.2 1.4 1 0 0 1 1 1 0 Phage RNA polymerase binding, RpbA HTH_29 PF13551.6 KII67706.1 - 0.012 15.6 0.5 0.078 13.0 0.0 2.4 3 0 0 3 3 3 0 Winged helix-turn helix HTH_28 PF13518.6 KII67706.1 - 0.014 15.5 0.0 0.034 14.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HrpB_C PF08482.10 KII67706.1 - 0.057 13.8 0.1 0.1 13.0 0.0 1.6 2 0 0 2 2 2 0 ATP-dependent helicase C-terminal PEP-utilizers_C PF02896.18 KII67706.1 - 0.099 11.7 0.2 0.11 11.5 0.2 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, TIM barrel domain APP_E2 PF12925.7 KII67706.1 - 1.5 8.5 5.0 9.2 5.9 0.2 2.1 1 1 1 2 2 2 0 E2 domain of amyloid precursor protein HTH_32 PF13565.6 KII67707.1 - 0.012 16.2 0.0 0.44 11.2 0.0 2.0 1 1 1 2 2 2 0 Homeodomain-like domain TIP41 PF04176.13 KII67708.1 - 1.5e-06 27.8 0.0 1.6e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 TIP41-like family MFS_Mycoplasma PF07672.13 KII67712.1 - 0.0067 15.8 0.4 0.015 14.6 0.4 1.5 1 0 0 1 1 1 1 Mycoplasma MFS transporter TMEM154 PF15102.6 KII67712.1 - 0.034 14.1 0.4 0.034 14.1 0.4 9.7 3 2 0 4 4 4 0 TMEM154 protein family Insulin_TMD PF17870.1 KII67712.1 - 0.097 12.8 2.6 0.22 11.6 2.6 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4320 PF14208.6 KII67712.1 - 5 7.2 9.7 10 6.2 0.2 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4320) Orf78 PF06024.12 KII67712.1 - 5.2 7.4 6.6 1.2 9.5 0.3 3.3 2 1 0 2 2 2 0 Orf78 (ac78) Baculo_11_kDa PF06143.11 KII67713.1 - 0.013 15.1 1.6 0.075 12.6 1.6 2.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family Syndecan PF01034.20 KII67713.1 - 0.062 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain RCR PF12273.8 KII67713.1 - 0.091 13.4 0.0 0.091 13.4 0.0 3.8 4 1 0 4 4 4 0 Chitin synthesis regulation, resistance to Congo red Insulin_TMD PF17870.1 KII67713.1 - 0.091 12.8 0.5 0.16 12.1 0.5 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment EphA2_TM PF14575.6 KII67713.1 - 0.4 11.6 2.9 1.2 10.1 0.0 3.3 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Chordopox_A13L PF05961.11 KII67713.1 - 3.7 7.9 0.0 3.7 7.9 0.0 4.7 4 0 0 4 4 4 0 Chordopoxvirus A13L protein DDE_Tnp_1_7 PF13843.6 KII67715.1 - 1.2e-05 24.8 0.0 1.4e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Transposase IS4 Insulin_TMD PF17870.1 KII67716.1 - 0.12 12.4 0.2 0.22 11.6 0.2 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment MFS_Mycoplasma PF07672.13 KII67716.1 - 4 6.7 5.5 0.42 9.9 0.1 2.0 2 0 0 2 2 2 0 Mycoplasma MFS transporter CTP_synth_N PF06418.14 KII67717.1 - 3.6e-97 324.8 5.3 2e-96 322.4 4.9 1.7 1 1 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 KII67717.1 - 2.5e-48 164.4 0.0 3.7e-48 163.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KII67717.1 - 1.8e-05 24.6 0.1 0.00016 21.5 0.2 2.5 2 1 0 2 2 2 1 Peptidase C26 Galactosyl_T PF01762.21 KII67718.1 - 3.1e-20 72.8 0.4 5.3e-20 72.1 0.4 1.3 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 KII67719.1 - 1.3e-25 90.4 3.9 1.8e-25 89.9 3.9 1.2 1 0 0 1 1 1 1 Galactosyltransferase SH2 PF00017.24 KII67720.1 - 0.014 15.5 0.5 0.024 14.7 0.5 1.4 1 0 0 1 1 1 0 SH2 domain RRM_1 PF00076.22 KII67724.1 - 1.1e-23 82.8 0.8 1.4e-11 44.0 0.0 3.1 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KII67724.1 - 6.4e-06 25.8 0.0 0.0038 16.8 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KII67724.1 - 0.00041 20.2 0.0 0.21 11.5 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif DUF4523 PF15023.6 KII67724.1 - 0.021 14.6 0.0 0.052 13.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Tropomyosin PF00261.20 KII67725.1 - 1.7e-09 37.4 43.7 5.8e-05 22.6 30.9 2.4 1 1 1 2 2 2 2 Tropomyosin ATG16 PF08614.11 KII67725.1 - 2.3e-05 24.7 41.3 0.018 15.3 7.7 3.1 1 1 2 3 3 3 2 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 KII67725.1 - 0.00034 20.7 40.4 0.021 14.8 11.8 3.1 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NPV_P10 PF05531.12 KII67725.1 - 0.00057 20.3 22.4 0.018 15.5 4.0 4.3 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 KII67725.1 - 0.0013 19.0 24.2 1.5 9.3 0.9 4.9 4 1 0 4 4 4 1 Flagella accessory protein C (FlaC) Fez1 PF06818.15 KII67725.1 - 0.0017 18.8 37.9 0.14 12.5 20.3 2.4 1 1 1 2 2 2 2 Fez1 Spc7 PF08317.11 KII67725.1 - 0.0019 17.1 42.0 0.02 13.8 12.8 2.9 1 1 2 3 3 3 2 Spc7 kinetochore protein APG6_N PF17675.1 KII67725.1 - 0.0021 18.6 49.3 0.093 13.3 15.0 3.1 1 1 2 3 3 3 2 Apg6 coiled-coil region Lebercilin PF15619.6 KII67725.1 - 0.0023 17.7 43.0 0.082 12.6 23.8 2.7 1 1 1 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease DUF2968 PF11180.8 KII67725.1 - 0.0058 16.3 28.7 0.16 11.6 7.9 3.1 1 1 1 3 3 3 2 Protein of unknown function (DUF2968) Sec2p PF06428.11 KII67725.1 - 0.007 16.3 6.6 0.007 16.3 6.6 4.4 2 1 0 3 3 3 1 GDP/GTP exchange factor Sec2p YlqD PF11068.8 KII67725.1 - 0.0079 16.6 33.5 0.0096 16.3 6.7 3.6 1 1 3 4 4 4 1 YlqD protein HAP1_N PF04849.13 KII67725.1 - 0.0082 15.4 35.3 0.06 12.5 13.2 3.2 1 1 3 4 4 4 3 HAP1 N-terminal conserved region EzrA PF06160.12 KII67725.1 - 0.0084 14.3 35.1 0.23 9.6 13.1 2.1 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA Myosin_tail_1 PF01576.19 KII67725.1 - 0.012 13.5 41.1 0.018 12.9 21.0 2.0 1 1 1 2 2 2 0 Myosin tail CALCOCO1 PF07888.11 KII67725.1 - 0.012 14.5 37.4 0.42 9.4 19.9 2.8 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like MscS_porin PF12795.7 KII67725.1 - 0.014 15.0 37.0 0.16 11.5 11.8 2.3 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain GAS PF13851.6 KII67725.1 - 0.017 14.5 43.0 0.044 13.1 12.6 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding HMMR_N PF15905.5 KII67725.1 - 0.022 14.2 42.0 1.3 8.5 41.8 2.7 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF4200 PF13863.6 KII67725.1 - 0.027 14.9 44.4 1 9.8 15.5 3.3 1 1 1 3 3 3 0 Domain of unknown function (DUF4200) Csm1_N PF18504.1 KII67725.1 - 0.038 14.3 5.5 0.038 14.3 5.5 5.2 1 1 3 5 5 5 0 Csm1 N-terminal domain TPR_MLP1_2 PF07926.12 KII67725.1 - 0.042 13.9 42.8 0.26 11.4 20.4 3.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein HOOK PF05622.12 KII67725.1 - 0.062 11.4 40.3 0.078 11.1 40.3 1.1 1 0 0 1 1 1 0 HOOK protein Golgin_A5 PF09787.9 KII67725.1 - 0.072 12.6 40.0 0.39 10.1 10.7 2.9 1 1 2 3 3 3 0 Golgin subfamily A member 5 Laminin_II PF06009.12 KII67725.1 - 0.074 13.1 29.9 0.49 10.4 7.1 3.8 1 1 1 3 3 3 0 Laminin Domain II DUF724 PF05266.14 KII67725.1 - 0.13 12.1 36.3 0.11 12.3 10.7 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF724) TMF_TATA_bd PF12325.8 KII67725.1 - 0.14 12.4 34.4 2.7 8.2 13.4 3.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Laminin_I PF06008.14 KII67725.1 - 0.15 11.8 34.5 0.062 13.0 8.1 2.4 1 1 2 3 3 3 0 Laminin Domain I DUF1664 PF07889.12 KII67725.1 - 0.19 11.8 25.2 0.59 10.2 4.9 3.9 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Flagellar_rod PF05149.12 KII67725.1 - 0.21 11.0 34.5 0.017 14.6 19.8 3.0 1 1 2 3 3 3 0 Paraflagellar rod protein DUF4201 PF13870.6 KII67725.1 - 0.24 11.1 37.0 2.3 7.9 10.9 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) ABC_tran_CTD PF16326.5 KII67725.1 - 0.3 11.3 38.3 0.16 12.2 4.3 4.6 1 1 4 5 5 5 0 ABC transporter C-terminal domain IFT57 PF10498.9 KII67725.1 - 0.39 9.6 34.3 0.19 10.7 6.2 2.9 1 1 2 3 3 3 0 Intra-flagellar transport protein 57 DUF641 PF04859.12 KII67725.1 - 0.47 10.8 32.4 2.3 8.6 8.7 3.5 1 1 1 3 3 3 0 Plant protein of unknown function (DUF641) MAD PF05557.13 KII67725.1 - 0.5 8.7 40.0 1.9 6.8 11.9 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Uso1_p115_C PF04871.13 KII67725.1 - 0.51 10.7 42.8 2 8.8 9.7 3.3 1 1 3 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region ERM PF00769.19 KII67725.1 - 0.54 10.0 42.3 1.3 8.8 13.0 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family HrpB7 PF09486.10 KII67725.1 - 0.84 10.0 29.3 0.67 10.3 10.3 3.2 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) TMF_DNA_bd PF12329.8 KII67725.1 - 0.9 9.6 41.2 0.14 12.2 4.0 4.4 2 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding Filament PF00038.21 KII67725.1 - 0.91 9.0 37.7 4.4 6.8 37.7 2.3 1 1 0 1 1 1 0 Intermediate filament protein DUF948 PF06103.11 KII67725.1 - 1.1 9.6 15.4 0.35 11.1 1.5 3.5 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) FPP PF05911.11 KII67725.1 - 1.1 7.3 40.3 0.28 9.3 12.3 2.6 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil HIP1_clath_bdg PF16515.5 KII67725.1 - 1.2 9.8 39.2 7 7.3 8.6 3.5 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0242 PF06785.11 KII67725.1 - 1.6 8.8 37.8 0.22 11.6 19.8 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Tup_N PF08581.10 KII67725.1 - 1.6 9.1 30.0 1.4 9.3 5.9 4.2 1 1 3 5 5 5 0 Tup N-terminal DUF4407 PF14362.6 KII67725.1 - 1.8 7.9 34.0 0.38 10.0 21.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Occludin_ELL PF07303.13 KII67725.1 - 2.6 8.8 27.5 13 6.5 3.4 4.7 1 1 2 4 4 4 0 Occludin homology domain BLOC1_2 PF10046.9 KII67725.1 - 3.4 8.0 27.6 0.86 9.9 6.2 3.8 1 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FH2 PF02181.23 KII67725.1 - 4 6.5 28.2 2.1 7.4 7.9 3.0 1 1 1 3 3 3 0 Formin Homology 2 Domain Exonuc_VII_L PF02601.15 KII67725.1 - 4.2 6.8 30.8 1.8e+04 -6.2 30.8 2.2 1 1 0 1 1 0 0 Exonuclease VII, large subunit Jnk-SapK_ap_N PF09744.9 KII67725.1 - 4.7 7.4 42.2 6.8 6.9 6.8 3.2 1 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Nsp1_C PF05064.13 KII67725.1 - 6.2 6.6 31.0 2.5 7.9 0.2 4.2 1 1 2 4 4 4 0 Nsp1-like C-terminal region SHE3 PF17078.5 KII67725.1 - 6.4 6.4 35.3 3.8 7.2 17.9 2.4 1 1 1 2 2 1 0 SWI5-dependent HO expression protein 3 V_ATPase_I PF01496.19 KII67725.1 - 7.2 4.4 29.0 0.32 8.8 13.0 2.2 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family CorA PF01544.18 KII67725.1 - 7.6 5.8 21.2 1.7 7.8 7.7 2.8 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein TMPIT PF07851.13 KII67725.1 - 7.6 5.7 29.4 3 7.0 11.5 2.4 1 1 1 2 2 2 0 TMPIT-like protein HemX PF04375.14 KII67725.1 - 9.6 5.4 33.2 5.2 6.2 10.5 3.1 1 1 2 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF3584 PF12128.8 KII67725.1 - 9.9 3.5 40.2 17 2.7 10.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) FDX-ACB PF03147.14 KII67726.1 - 1.1e-21 77.0 0.0 1.4e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2d PF01409.20 KII67726.1 - 0.00013 21.5 0.0 0.0002 20.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2d PF01409.20 KII67727.1 - 4.9e-34 117.9 0.1 4e-33 114.9 0.1 1.9 1 1 1 2 2 2 2 tRNA synthetases class II core domain (F) DUF5309 PF17236.2 KII67727.1 - 0.2 11.0 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5309) Vinculin PF01044.19 KII67728.1 - 1.6e-37 129.3 35.7 6.8e-19 67.7 4.6 2.7 2 1 0 2 2 2 2 Vinculin family Herpes_UL3 PF03369.13 KII67728.1 - 0.17 12.4 1.7 0.44 11.1 1.7 1.7 1 0 0 1 1 1 0 Herpesvirus UL3 protein LepB_N PF18640.1 KII67728.1 - 1.7 8.3 21.5 0.06 13.0 2.5 4.2 4 0 0 4 4 4 0 LepB N-terminal domain Noggin PF05806.12 KII67729.1 - 2.1e-08 34.4 8.3 2e-07 31.1 8.4 2.0 1 1 0 1 1 1 1 Noggin HTH_33 PF13592.6 KII67731.1 - 0.0023 17.5 0.0 0.013 15.1 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix CAMSAP_CKK PF08683.11 KII67732.1 - 8.8e-22 77.5 0.1 1.1e-21 77.1 0.1 1.1 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated DUF787 PF05619.11 KII67732.1 - 0.0035 16.5 0.4 0.063 12.4 0.0 2.0 1 1 1 2 2 2 2 Borrelia burgdorferi protein of unknown function (DUF787) Glyco_hydro_85 PF03644.13 KII67734.1 - 8e-39 133.8 1.9 9.7e-39 133.6 1.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 HigB-like_toxin PF05015.13 KII67735.1 - 0.021 15.2 0.5 0.041 14.3 0.5 1.5 1 0 0 1 1 1 0 RelE-like toxin of type II toxin-antitoxin system HigB Mei5 PF10376.9 KII67735.1 - 0.059 13.2 2.3 0.091 12.6 2.3 1.3 1 0 0 1 1 1 0 Double-strand recombination repair protein HSP70 PF00012.20 KII67735.1 - 0.076 11.2 2.2 0.1 10.8 2.2 1.1 1 0 0 1 1 1 0 Hsp70 protein Dimer_Tnp_hAT PF05699.14 KII67736.1 - 0.017 14.9 0.4 0.086 12.6 0.1 2.3 2 1 0 2 2 2 0 hAT family C-terminal dimerisation region Noggin PF05806.12 KII67737.1 - 1.6e-10 41.3 11.3 2.3e-10 40.8 11.3 1.5 1 1 0 1 1 1 1 Noggin Arg_repressor PF01316.21 KII67737.1 - 0.15 11.8 0.4 0.32 10.8 0.4 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain SBF_like PF13593.6 KII67738.1 - 4.7e-38 131.3 30.1 9.7e-37 126.9 30.1 2.0 1 1 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 KII67738.1 - 9.7e-10 38.4 12.4 9.7e-10 38.4 12.4 2.7 2 2 0 2 2 2 1 Sodium Bile acid symporter family HTH_3 PF01381.22 KII67740.1 - 4.9e-09 36.1 0.2 7.2e-09 35.6 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 KII67740.1 - 0.0017 18.3 0.1 0.0022 17.9 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 KII67740.1 - 0.0021 18.4 0.0 0.003 17.9 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain CDC45 PF02724.14 KII67742.1 - 2.4e-70 237.6 5.0 2.8e-45 154.8 0.4 3.0 1 1 2 3 3 3 3 CDC45-like protein Sortilin_C PF15901.5 KII67745.1 - 1.4e-09 38.5 0.3 3.2e-09 37.4 0.3 1.6 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII67745.1 - 2.7e-08 33.0 9.2 1.6e-06 27.2 1.4 2.3 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII67745.1 - 5 7.5 13.9 10 6.6 0.1 4.7 5 0 0 5 5 5 0 BNR/Asp-box repeat TMEM51 PF15345.6 KII67747.1 - 0.1 12.4 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4969 PF16339.5 KII67748.1 - 0.022 15.1 4.5 0.088 13.2 0.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4969) Phage_connect_1 PF05135.13 KII67748.1 - 0.024 15.1 1.2 0.033 14.7 1.2 1.3 1 1 0 1 1 1 0 Phage gp6-like head-tail connector protein Kunitz_BPTI PF00014.23 KII67749.1 - 0.59 10.4 11.3 0.052 13.8 4.4 2.6 2 2 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF3112 PF11309.8 KII67751.1 - 0.15 11.5 0.2 0.21 11.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) MULE PF10551.9 KII67752.1 - 7.2e-15 55.2 0.0 1.4e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain RT_RNaseH_2 PF17919.1 KII67753.1 - 2.3e-19 69.3 0.3 5.1e-19 68.2 0.1 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67753.1 - 3.8e-08 33.6 0.2 8.8e-08 32.4 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67754.1 - 9.3e-16 58.0 0.1 1.8e-15 57.1 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII67754.1 - 4.1e-11 42.8 0.1 1.1e-10 41.5 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Utp13 PF08625.11 KII67754.1 - 0.049 13.5 0.0 3.5 7.5 0.0 2.9 3 0 0 3 3 3 0 Utp13 specific WD40 associated domain PepSY_like PF11396.8 KII67754.1 - 0.077 13.6 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 Putative beta-lactamase-inhibitor-like, PepSY-like Abhydrolase_1 PF00561.20 KII67756.1 - 3.4e-07 30.2 0.3 0.00029 20.6 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KII67756.1 - 4.8e-07 29.3 0.3 0.00026 20.4 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DUF818 PF05677.12 KII67756.1 - 1.7e-06 27.3 0.3 2.9e-06 26.5 0.3 1.5 1 1 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) DUF1057 PF06342.12 KII67756.1 - 1.8e-05 23.9 0.0 3.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_6 PF12697.7 KII67756.1 - 2.8e-05 24.8 0.0 0.00027 21.6 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 KII67756.1 - 0.0024 17.7 0.1 0.02 14.7 0.1 2.3 1 1 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KII67756.1 - 0.0048 16.4 0.0 0.031 13.8 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 KII67756.1 - 0.056 13.1 0.0 0.082 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF2235 PF09994.9 KII67756.1 - 0.069 12.5 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) DLH PF01738.18 KII67756.1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S15 PF02129.18 KII67756.1 - 0.24 11.0 0.1 0.35 10.4 0.1 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF5482 PF17579.2 KII67759.1 - 0.16 11.8 3.9 0.43 10.5 0.8 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5482) FCH PF00611.23 KII67760.1 - 0.014 15.6 0.1 0.016 15.5 0.1 1.2 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Snf7 PF03357.21 KII67761.1 - 0.071 12.7 7.8 0.14 11.8 7.8 1.6 1 1 0 1 1 1 0 Snf7 C2 PF00168.30 KII67764.1 - 0.0018 18.5 0.3 0.0022 18.2 0.3 1.1 1 0 0 1 1 1 1 C2 domain rve PF00665.26 KII67769.1 - 7.4e-07 29.4 0.0 1.1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain gag-asp_proteas PF13975.6 KII67771.1 - 0.01 16.3 0.0 0.073 13.6 0.0 2.4 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII67771.1 - 0.011 16.0 0.0 0.045 14.1 0.0 2.0 2 1 0 2 2 2 0 Retroviral aspartyl protease DUF678 PF05077.12 KII67774.1 - 0.09 12.9 3.9 0.32 11.2 3.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF678) RVT_1 PF00078.27 KII67775.1 - 1e-09 38.2 1.1 4.4e-09 36.2 0.1 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) HJURP_C PF12347.8 KII67775.1 - 0.47 10.5 4.2 7.7 6.6 0.0 3.2 3 0 0 3 3 3 0 Holliday junction regulator protein family C-terminal repeat RVT_1 PF00078.27 KII67776.1 - 7e-10 38.8 1.2 3.1e-09 36.7 0.1 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF678 PF05077.12 KII67777.1 - 0.09 12.9 3.9 0.32 11.2 3.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF678) NusG_II PF07009.11 KII67779.1 - 0.029 14.6 0.5 0.079 13.2 0.0 1.9 1 1 2 3 3 3 0 NusG domain II TBD PF12845.7 KII67779.1 - 0.047 13.6 0.2 0.11 12.5 0.2 1.5 1 0 0 1 1 1 0 TBD domain Peptidase_S9 PF00326.21 KII67780.1 - 3.6e-09 36.4 0.0 4.2e-09 36.2 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 KII67780.1 - 0.0011 18.6 0.0 0.0013 18.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 KII67780.1 - 0.0052 16.1 0.0 0.007 15.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 KII67780.1 - 0.021 14.5 0.0 0.023 14.4 0.0 1.1 1 0 0 1 1 1 0 Serine hydrolase (FSH1) RNase_PH PF01138.21 KII67782.1 - 1.6e-10 41.6 0.1 2.6e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 VCBS PF13517.6 KII67783.1 - 0.0018 18.8 1.4 0.0066 17.0 0.7 2.4 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII67783.1 - 0.0085 16.2 0.1 21 5.4 0.0 3.4 3 0 0 3 3 3 2 FG-GAP repeat ACC_central PF08326.12 KII67787.1 - 2e-126 423.1 5.4 2e-126 423.1 5.4 1.4 2 0 0 2 2 2 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 KII67787.1 - 2.8e-113 379.2 0.0 4.3e-113 378.6 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 KII67787.1 - 3.1e-49 167.4 0.0 6e-49 166.4 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 KII67787.1 - 9.8e-18 64.2 0.0 3.7e-17 62.4 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 KII67787.1 - 2.5e-13 50.5 0.0 6.1e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 KII67787.1 - 1.5e-11 43.9 0.1 5.6e-11 42.1 0.0 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme ATP-grasp PF02222.22 KII67787.1 - 8.5e-05 22.2 0.0 0.00022 20.8 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KII67787.1 - 0.00071 19.7 0.5 0.0019 18.3 0.1 2.0 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KII67787.1 - 0.0036 16.9 0.0 0.0076 15.8 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus DUF4910 PF16254.5 KII67787.1 - 0.04 12.8 0.1 0.085 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4910) Nipped-B_C PF12830.7 KII67789.1 - 8.3e-24 84.6 2.3 8.3e-24 84.6 2.3 4.5 6 0 0 6 6 6 1 Sister chromatid cohesion C-terminus Cnd1 PF12717.7 KII67789.1 - 3e-05 24.1 23.9 0.0024 17.9 3.7 5.1 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KII67789.1 - 0.00014 21.9 0.3 13 6.4 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat TIP120 PF08623.10 KII67789.1 - 0.0058 16.4 4.5 0.0097 15.7 0.1 3.4 2 1 1 3 3 3 1 TATA-binding protein interacting (TIP20) Cohesin_HEAT PF12765.7 KII67789.1 - 0.22 11.8 2.4 1.7 9.0 0.1 3.1 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion DUF489 PF04356.12 KII67789.1 - 0.53 10.3 4.8 12 5.9 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF489) DDE_3 PF13358.6 KII67790.1 - 0.0008 19.2 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease VESA1_N PF12785.7 KII67790.1 - 0.2 10.6 0.1 0.23 10.4 0.1 1.1 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 DDE_3 PF13358.6 KII67791.1 - 0.0005 19.8 0.0 0.0009 19.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3523 PF12037.8 KII67792.1 - 1e-38 133.3 7.2 1.5e-38 132.7 7.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 KII67792.1 - 1.1e-22 80.9 0.0 2.5e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII67792.1 - 0.00011 22.7 0.0 0.022 15.1 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 KII67792.1 - 0.00031 20.8 0.1 0.0037 17.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KII67792.1 - 0.00074 19.3 0.0 0.0018 18.0 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KII67792.1 - 0.0027 18.0 0.1 0.3 11.4 0.0 2.6 1 1 0 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 KII67792.1 - 0.0033 17.2 0.1 0.0091 15.8 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Mg_chelatase PF01078.21 KII67792.1 - 0.0034 16.8 0.3 0.049 13.0 0.0 2.7 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KII67792.1 - 0.0038 17.4 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KII67792.1 - 0.0056 16.9 0.5 0.44 10.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KII67792.1 - 0.0098 16.3 0.7 0.091 13.2 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_7 PF12775.7 KII67792.1 - 0.041 13.4 0.0 0.093 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 KII67792.1 - 0.042 13.9 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 KII67792.1 - 0.044 13.5 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF3181 PF11378.8 KII67792.1 - 0.051 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3181) AAA_18 PF13238.6 KII67792.1 - 0.052 14.1 1.1 0.21 12.1 0.0 2.6 3 1 1 4 4 2 0 AAA domain Sigma54_activ_2 PF14532.6 KII67792.1 - 0.072 13.2 0.0 0.39 10.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain DNA_pol3_delta2 PF13177.6 KII67792.1 - 0.078 12.8 2.7 3.4 7.4 0.0 3.0 3 0 0 3 3 3 0 DNA polymerase III, delta subunit AAA_25 PF13481.6 KII67792.1 - 0.12 11.9 0.1 0.37 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KII67792.1 - 0.15 12.5 0.0 0.15 12.5 0.0 2.9 3 1 1 4 4 4 0 AAA domain AAA_11 PF13086.6 KII67792.1 - 0.46 10.2 0.0 0.46 10.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain VSP PF03302.13 KII67794.1 - 8e-05 21.7 0.9 9.1e-05 21.5 0.9 1.0 1 0 0 1 1 1 1 Giardia variant-specific surface protein zf-CCHC PF00098.23 KII67794.1 - 0.015 15.4 1.9 0.015 15.4 1.9 2.2 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.6 KII67794.1 - 0.24 11.3 3.6 0.76 9.7 3.6 1.8 1 0 0 1 1 1 0 Zinc knuckle SNAP PF14938.6 KII67795.1 - 3.4e-11 43.1 0.9 3.8e-11 42.9 0.9 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NSF PF02071.20 KII67795.1 - 0.45 11.5 4.0 48 5.4 0.3 4.0 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.17 KII67795.1 - 0.95 9.7 3.3 3.1 8.2 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII67795.1 - 4.3 7.3 0.0 4.3 7.3 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 KII67796.1 - 8e-31 107.1 1.4 4.8e-30 104.6 0.7 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 2 PS_pyruv_trans PF04230.13 KII67796.1 - 3e-27 96.3 0.1 7.6e-27 95.0 0.1 1.7 1 0 0 1 1 1 1 Polysaccharide pyruvyl transferase Glyco_tranf_2_3 PF13641.6 KII67796.1 - 2.6e-14 53.7 0.0 4.6e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KII67796.1 - 1.7e-09 37.6 0.2 3.2e-09 36.7 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KII67796.1 - 0.0064 17.0 0.0 0.022 15.3 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 Peptidase_S24 PF00717.23 KII67796.1 - 0.11 12.4 0.7 2.3 8.3 0.1 2.5 2 0 0 2 2 2 0 Peptidase S24-like UDPG_MGDP_dh_N PF03721.14 KII67797.1 - 2.7e-34 118.4 0.2 4.1e-34 117.8 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 KII67797.1 - 2.4e-26 91.8 0.0 4.7e-26 90.8 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 KII67797.1 - 3.8e-09 36.9 0.8 9.9e-07 29.1 0.0 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 3HCDH_N PF02737.18 KII67797.1 - 0.00028 20.8 0.0 0.0011 18.9 0.0 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 KII67797.1 - 0.0044 17.1 0.1 0.0094 16.1 0.1 1.6 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 KII67797.1 - 0.007 16.4 0.1 0.015 15.3 0.0 1.6 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Glyco_hydro_4 PF02056.16 KII67797.1 - 0.012 15.2 0.6 0.049 13.2 0.2 2.1 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase F420_oxidored PF03807.17 KII67797.1 - 0.016 15.8 0.1 1.3 9.6 0.0 3.4 3 1 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 KII67797.1 - 0.016 14.8 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ZnuA PF01297.17 KII67797.1 - 0.024 14.1 0.5 2.5 7.4 0.0 2.8 3 0 0 3 3 3 0 Zinc-uptake complex component A periplasmic Methyltransf_16 PF10294.9 KII67797.1 - 0.044 13.5 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase Prenylcys_lyase PF07156.14 KII67797.1 - 0.24 10.5 0.7 0.35 9.9 0.7 1.2 1 0 0 1 1 1 0 Prenylcysteine lyase 6PGD PF00393.19 KII67798.1 - 1.4e-116 388.9 1.9 1e-115 386.1 1.9 2.1 1 1 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KII67798.1 - 1.7e-52 177.7 0.0 1.8e-51 174.4 0.0 2.3 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 KII67798.1 - 0.00021 21.0 0.0 0.00041 20.0 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 KII67798.1 - 0.0005 20.6 0.1 0.0025 18.4 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 KII67798.1 - 0.0025 17.9 0.1 0.0063 16.6 0.1 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 KII67798.1 - 0.0098 15.8 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 KII67798.1 - 0.028 14.4 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 KII67798.1 - 0.032 13.6 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KII67798.1 - 0.12 11.9 0.2 0.8 9.3 0.0 2.3 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Pallilysin PF18663.1 KII67799.1 - 0.043 13.8 0.3 0.16 11.9 0.3 1.9 1 0 0 1 1 1 0 Pallilysin beta barrel domain Glycos_transf_1 PF00534.20 KII67800.1 - 1.1e-10 41.3 0.0 3e-10 39.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 RmlD_sub_bind PF04321.17 KII67801.1 - 6.3e-32 110.8 0.0 7e-32 110.7 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain dTDP_sugar_isom PF00908.17 KII67802.1 - 5.3e-75 250.7 0.0 5.9e-75 250.6 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase NTP_transferase PF00483.23 KII67803.1 - 7.4e-50 169.8 0.0 8.8e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase DUF3234 PF11572.8 KII67803.1 - 0.019 15.2 0.1 0.27 11.5 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3234) GDP_Man_Dehyd PF16363.5 KII67804.1 - 4.7e-95 318.8 0.0 5.4e-95 318.6 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KII67804.1 - 1.3e-70 237.6 0.0 1.6e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KII67804.1 - 4e-15 55.7 0.0 5.7e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 KII67804.1 - 1.4e-13 50.6 0.0 1.3e-09 37.6 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 KII67804.1 - 2.3e-13 49.8 0.0 4.4e-13 48.9 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KII67804.1 - 6.4e-13 48.5 0.0 9.9e-13 47.8 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 KII67804.1 - 0.0041 16.6 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 KII67804.1 - 0.014 15.6 0.1 0.024 14.9 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 KII67804.1 - 0.037 14.0 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 KR domain Ldh_1_N PF00056.23 KII67804.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Glycos_transf_2 PF00535.26 KII67805.1 - 6.2e-14 52.2 0.0 9.8e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KII67805.1 - 1.5e-09 38.1 0.0 2.2e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 KII67805.1 - 2.1e-05 24.1 0.0 4.2e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 KII67805.1 - 0.00015 21.8 0.0 0.00021 21.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Bac_transf PF02397.16 KII67806.1 - 1.5e-65 220.3 0.0 2.1e-65 219.8 0.0 1.2 1 0 0 1 1 1 1 Bacterial sugar transferase CoA_binding_3 PF13727.6 KII67806.1 - 2.2e-06 27.8 0.0 5.3e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 CoA-binding domain LMWPc PF01451.21 KII67807.1 - 2.9e-39 134.7 0.0 6.5e-39 133.5 0.0 1.6 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase GNVR PF13807.6 KII67807.1 - 2.6e-33 113.8 0.6 7.6e-33 112.3 0.6 1.9 1 0 0 1 1 1 1 G-rich domain on putative tyrosine kinase Poly_export PF02563.16 KII67807.1 - 4.4e-28 97.3 0.1 1.3e-27 95.8 0.1 1.8 1 0 0 1 1 1 1 Polysaccharide biosynthesis/export protein Wzz PF02706.15 KII67807.1 - 4.5e-26 91.0 0.4 1.5e-25 89.3 0.4 2.0 1 0 0 1 1 1 1 Chain length determinant protein AAA_31 PF13614.6 KII67807.1 - 1.9e-12 47.5 0.5 1.3e-11 44.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain SLBB PF10531.9 KII67807.1 - 8.9e-12 44.7 0.3 1.7e-07 31.0 0.1 2.9 2 0 0 2 2 2 2 SLBB domain CbiA PF01656.23 KII67807.1 - 1.6e-06 28.2 0.5 8.6e-06 25.8 0.0 2.4 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 KII67807.1 - 1.9e-06 27.8 1.4 0.05 13.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain ParA PF10609.9 KII67807.1 - 0.00063 19.3 0.0 0.0014 18.1 0.0 1.6 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase LMBR1 PF04791.16 KII67807.1 - 0.014 14.4 0.7 0.024 13.6 0.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein ArsA_ATPase PF02374.15 KII67807.1 - 0.017 14.3 5.6 0.86 8.7 0.1 3.7 3 1 1 4 4 4 0 Anion-transporting ATPase Fer4_NifH PF00142.18 KII67807.1 - 0.032 13.7 0.1 0.098 12.1 0.1 1.8 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family OmpH PF03938.14 KII67807.1 - 0.08 13.3 4.5 0.24 11.7 4.5 1.8 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Occludin_ELL PF07303.13 KII67807.1 - 0.16 12.7 1.5 0.39 11.5 0.8 1.9 1 1 0 1 1 1 0 Occludin homology domain T2SSM PF04612.12 KII67807.1 - 0.21 11.7 4.8 0.076 13.1 0.4 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M CCDC-167 PF15188.6 KII67807.1 - 2.4 8.5 6.7 86 3.6 5.7 3.1 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Caps_assemb_Wzi PF14052.6 KII67808.1 - 1e-14 54.4 1.2 8.2e-10 38.3 0.2 2.1 1 1 1 2 2 2 2 Capsule assembly protein Wzi PAP2 PF01569.21 KII67809.1 - 3.6e-09 36.5 9.3 3.6e-09 36.5 9.3 2.2 1 1 1 2 2 2 1 PAP2 superfamily INSIG PF07281.12 KII67809.1 - 0.0079 15.9 2.8 0.026 14.2 2.8 1.8 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) NTP_transferase PF00483.23 KII67810.1 - 4.7e-20 72.2 0.0 6.3e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KII67810.1 - 7.8e-05 23.1 0.1 0.00015 22.2 0.1 1.7 1 1 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 KII67810.1 - 0.14 12.1 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Cytidylyltransferase CorC_HlyC PF03471.17 KII67812.1 - 5.7e-21 74.3 0.2 1.8e-19 69.5 0.0 2.4 1 1 1 2 2 2 1 Transporter associated domain CBS PF00571.28 KII67812.1 - 1.3e-15 57.5 1.0 4.3e-08 33.5 0.0 2.8 3 0 0 3 3 3 2 CBS domain DUF2635 PF10948.8 KII67812.1 - 0.014 15.1 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2635) AsmA_2 PF13502.6 KII67813.1 - 2.2e-06 27.4 0.1 3.2e-06 26.8 0.1 1.4 1 1 0 1 1 1 1 AsmA-like C-terminal region Eno-Rase_FAD_bd PF07055.12 KII67813.1 - 0.63 10.5 4.6 1.1 9.8 0.4 2.2 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain PUB PF09409.10 KII67814.1 - 2.9e-09 36.7 0.0 5.6e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 PUB domain Dimer_Tnp_hAT PF05699.14 KII67817.1 - 0.00018 21.2 0.1 0.00034 20.4 0.1 1.4 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region FbpA PF05833.11 KII67818.1 - 0.012 14.3 1.5 0.02 13.7 1.5 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Ank_2 PF12796.7 KII67819.1 - 1.4e-24 86.5 0.2 1.2e-12 48.2 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII67819.1 - 1.5e-18 66.9 1.5 2.8e-11 43.7 0.2 4.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KII67819.1 - 1.5e-16 60.2 0.3 1.2e-07 31.8 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KII67819.1 - 2.7e-14 52.9 3.7 0.00016 22.0 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 KII67819.1 - 4.1e-14 51.3 1.1 9.4e-05 22.5 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat TPR_12 PF13424.6 KII67819.1 - 9e-14 51.5 6.0 0.0057 16.9 0.1 5.1 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KII67819.1 - 0.00029 20.3 0.6 0.0021 17.5 0.5 2.5 1 1 0 1 1 1 1 MalT-like TPR region PACT_coil_coil PF10495.9 KII67819.1 - 0.0031 18.1 1.6 0.37 11.4 0.1 3.7 4 0 0 4 4 4 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein SHNi-TPR PF10516.9 KII67819.1 - 0.012 15.0 1.4 0.26 10.8 0.1 3.4 3 0 0 3 3 3 0 SHNi-TPR ANAPC5 PF12862.7 KII67819.1 - 0.068 13.2 1.1 7.1 6.8 0.0 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 HTH_48 PF17906.1 KII67819.1 - 0.15 12.2 0.5 6.2 7.0 0.0 3.1 3 0 0 3 3 3 0 HTH domain in Mos1 transposase TPR_2 PF07719.17 KII67819.1 - 0.23 11.7 20.9 5.7 7.3 0.1 7.8 9 0 0 9 9 8 0 Tetratricopeptide repeat Metallophos PF00149.28 KII67825.1 - 4.3e-05 24.1 0.3 5.4e-05 23.8 0.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase BNR_assoc_N PF14873.6 KII67828.1 - 0.081 12.6 0.0 0.097 12.4 0.0 1.1 1 0 0 1 1 1 0 N-terminal domain of BNR-repeat neuraminidase Ldl_recept_a PF00057.18 KII67830.1 - 5.2e-17 61.8 28.7 1.7e-10 41.0 13.4 2.1 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A ADAM_CR PF08516.12 KII67830.1 - 7.1 7.1 20.1 2.7 8.4 6.6 2.1 1 1 1 2 2 2 0 ADAM cysteine-rich Ldl_recept_a PF00057.18 KII67833.1 - 1.9e-33 114.4 125.7 8.8e-11 41.8 11.1 8.2 7 1 1 8 8 8 7 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII67835.1 - 1.2e-08 34.2 1.2 0.0018 17.2 0.1 2.4 1 1 2 3 3 3 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII67835.1 - 0.0007 19.2 4.6 1.3 9.3 0.9 3.5 3 0 0 3 3 3 2 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII67836.1 - 8.6e-19 67.6 0.7 8.6e-19 67.6 0.7 1.9 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII67836.1 - 2.1e-12 47.0 29.6 9.9e-10 38.5 11.3 4.5 5 0 0 5 5 5 2 Low-density lipoprotein receptor domain class A BNR PF02012.20 KII67836.1 - 0.011 15.6 10.7 1.7 9.0 0.2 4.4 4 0 0 4 4 4 0 BNR/Asp-box repeat Ldl_recept_a PF00057.18 KII67837.1 - 1.5e-15 57.1 25.9 5.9e-11 42.4 11.2 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A DUF5017 PF16409.5 KII67837.1 - 0.045 13.2 0.0 0.057 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5017) Sortilin-Vps10 PF15902.5 KII67838.1 - 1.8e-12 46.8 0.5 5.2e-12 45.3 0.1 1.9 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII67838.1 - 0.067 13.2 8.9 0.71 10.1 0.8 3.1 3 0 0 3 3 3 0 BNR/Asp-box repeat Kelch_4 PF13418.6 KII67838.1 - 0.19 11.8 0.6 0.75 9.9 0.1 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain UPF0223 PF05256.12 KII67839.1 - 0.047 14.0 1.4 0.098 13.0 0.4 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) CRF-BP PF05428.11 KII67839.1 - 0.094 11.5 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Corticotropin-releasing factor binding protein (CRF-BP) Sortilin-Vps10 PF15902.5 KII67840.1 - 1.6e-15 56.8 0.2 3.3e-13 49.2 0.0 1.7 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, Mo-co_dimer PF03404.16 KII67840.1 - 0.026 14.5 0.0 15 5.6 0.0 3.0 3 0 0 3 3 3 0 Mo-co oxidoreductase dimerisation domain BNR PF02012.20 KII67840.1 - 0.94 9.7 7.0 30 5.2 0.5 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat Baculo_VP39 PF04501.12 KII67841.1 - 0.037 13.5 12.1 0.11 11.9 4.9 2.1 1 1 1 2 2 2 0 Baculovirus major capsid protein VP39 RT_RNaseH PF17917.1 KII67842.1 - 1.3e-28 99.4 0.0 1.8e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII67842.1 - 8.2e-27 93.2 0.0 1.1e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase YgbB PF02542.16 KII67842.1 - 0.049 13.9 0.0 0.073 13.4 0.0 1.2 1 0 0 1 1 1 0 YgbB family FAA_hydrolase PF01557.18 KII67843.1 - 1.1e-33 116.8 0.0 1.4e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family CPSF100_C PF13299.6 KII67844.1 - 0.0093 16.2 0.0 0.011 15.9 0.0 1.1 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal DUF1640 PF07798.11 KII67847.1 - 2.9 7.9 6.8 65 3.5 7.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) YmzC PF14157.6 KII67848.1 - 0.0074 16.4 0.1 0.016 15.3 0.1 1.6 1 0 0 1 1 1 1 YmzC-like protein HAMP PF00672.25 KII67848.1 - 0.031 14.7 0.0 0.045 14.1 0.0 1.3 1 0 0 1 1 1 0 HAMP domain WXG100 PF06013.12 KII67848.1 - 0.11 12.7 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Proteins of 100 residues with WXG MFS_1 PF07690.16 KII67849.1 - 3.5e-17 62.4 46.3 3.5e-17 62.4 46.3 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF5408 PF17402.2 KII67849.1 - 0.8 9.6 3.1 1.9 8.4 0.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5408) Molybdopterin PF00384.22 KII67850.1 - 1.5e-80 271.3 0.1 1.7e-80 271.1 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 KII67850.1 - 4.5e-21 75.0 0.0 1e-20 73.8 0.0 1.6 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Nitr_red_alph_N PF14710.6 KII67850.1 - 9.6e-15 54.8 3.1 2.4e-14 53.5 3.1 1.7 1 0 0 1 1 1 1 Respiratory nitrate reductase alpha N-terminal Molybdop_Fe4S4 PF04879.16 KII67850.1 - 0.0011 18.8 0.2 0.006 16.6 0.1 2.2 2 0 0 2 2 2 1 Molybdopterin oxidoreductase Fe4S4 domain Nitr_red_bet_C PF14711.6 KII67851.1 - 4.5e-29 100.0 0.0 8.3e-29 99.1 0.0 1.5 1 0 0 1 1 1 1 Respiratory nitrate reductase beta C-terminal Fer4_11 PF13247.6 KII67851.1 - 3.2e-27 94.6 7.8 6.8e-27 93.5 7.8 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Nitrate_red_del PF02613.15 KII67851.1 - 1.1e-08 35.1 0.1 4.4e-08 33.2 0.1 2.0 2 0 0 2 2 2 1 Nitrate reductase delta subunit Fer4_7 PF12838.7 KII67851.1 - 2.9e-05 24.6 18.9 0.064 13.8 0.1 4.0 2 1 2 4 4 4 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 KII67851.1 - 0.0002 21.4 20.2 0.1 12.7 4.4 3.7 4 0 0 4 4 4 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 KII67851.1 - 0.00022 21.1 15.7 0.031 14.3 2.2 3.9 3 0 0 3 3 3 3 4Fe-4S binding domain Fer4_6 PF12837.7 KII67851.1 - 0.0039 17.2 21.0 0.0075 16.3 0.1 3.9 3 1 1 4 4 3 2 4Fe-4S binding domain Fer4 PF00037.27 KII67851.1 - 0.023 14.5 2.0 0.023 14.5 2.0 4.7 3 1 1 4 4 4 0 4Fe-4S binding domain Fer4_13 PF13370.6 KII67851.1 - 0.072 13.6 0.1 0.072 13.6 0.1 3.5 3 0 0 3 3 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_9 PF13187.6 KII67851.1 - 0.14 12.3 18.4 0.36 11.0 0.4 3.7 2 1 1 3 3 3 0 4Fe-4S dicluster domain Fer4_15 PF13459.6 KII67851.1 - 0.28 11.9 9.2 2.3 9.0 0.1 3.1 3 0 0 3 3 2 0 4Fe-4S single cluster domain Fer4_4 PF12800.7 KII67851.1 - 0.46 11.1 18.3 3.8 8.3 1.5 4.0 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_17 PF13534.6 KII67851.1 - 1.7 9.2 13.0 2.3 8.9 0.2 3.9 3 1 0 3 3 3 0 4Fe-4S dicluster domain Nitrate_red_gam PF02665.14 KII67852.1 - 1.9e-35 122.4 9.5 2.4e-35 122.1 8.8 1.5 1 1 0 1 1 1 1 Nitrate reductase gamma subunit SUR7 PF06687.12 KII67852.1 - 0.043 13.5 0.5 0.043 13.5 0.5 1.6 1 1 0 1 1 1 0 SUR7/PalI family MarR_2 PF12802.7 KII67853.1 - 7.1e-15 54.6 0.1 1.2e-14 53.9 0.1 1.4 1 0 0 1 1 1 1 MarR family MarR PF01047.22 KII67853.1 - 4.3e-08 32.9 0.3 2.7e-07 30.4 0.0 2.3 3 0 0 3 3 3 1 MarR family HTH_27 PF13463.6 KII67853.1 - 5.3e-08 33.3 0.1 8.6e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain Dimerisation2 PF16864.5 KII67853.1 - 0.0012 18.8 0.5 0.0034 17.3 0.3 1.8 1 1 1 2 2 2 1 Dimerisation domain FeoC PF09012.10 KII67853.1 - 0.013 15.6 0.2 1 9.5 0.0 2.2 1 1 1 2 2 2 0 FeoC like transcriptional regulator ANT PF03374.14 KII67853.1 - 0.015 15.6 0.7 0.037 14.3 0.1 2.1 2 1 0 2 2 2 0 Phage antirepressor protein KilAC domain AAA_assoc_C PF09821.9 KII67853.1 - 0.039 14.5 0.4 0.095 13.2 0.2 1.8 2 1 0 2 2 2 0 C-terminal AAA-associated domain PadR PF03551.14 KII67853.1 - 0.064 13.2 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_34 PF13601.6 KII67853.1 - 0.072 13.3 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain Flavin_Reduct PF01613.18 KII67854.1 - 3.7e-11 43.3 0.0 4.6e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Corona_NS4 PF03905.13 KII67854.1 - 0.0084 16.1 1.3 0.017 15.1 1.3 1.4 1 0 0 1 1 1 1 Coronavirus non-structural protein NS4 DGC PF08859.11 KII67855.1 - 5.6e-25 87.5 0.1 6.9e-25 87.2 0.1 1.1 1 0 0 1 1 1 1 DGC domain DDE_Tnp_IS1595 PF12762.7 KII67856.1 - 2.4e-12 47.1 0.0 3.2e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain AlkA_N PF06029.11 KII67857.1 - 0.01 16.1 0.4 0.022 15.0 0.4 1.5 1 1 0 1 1 1 0 AlkA N-terminal domain DUF892 PF05974.12 KII67857.1 - 0.019 15.0 1.2 0.025 14.6 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF892) Hairpins PF04877.12 KII67857.1 - 0.07 12.8 0.1 0.087 12.4 0.1 1.2 1 0 0 1 1 1 0 HrpZ MCU PF04678.13 KII67857.1 - 0.3 11.1 3.3 0.96 9.5 3.3 1.8 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Rpn3_C PF08375.11 KII67857.1 - 0.41 11.1 4.6 0.25 11.8 1.5 2.2 2 1 0 2 2 2 0 Proteasome regulatory subunit C-terminal DUF1690 PF07956.11 KII67857.1 - 2.2 8.7 7.1 0.9 10.0 2.8 1.9 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) SIR2 PF02146.17 KII67861.1 - 0.17 11.8 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Sir2 family P4Ha_N PF08336.11 KII67862.1 - 9.5e-11 41.9 0.8 7.6e-10 38.9 0.0 2.8 3 0 0 3 3 3 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_12 PF13424.6 KII67862.1 - 0.14 12.4 0.1 0.29 11.4 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat BLOC1_2 PF10046.9 KII67863.1 - 0.00013 22.2 0.4 0.00021 21.5 0.4 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lzipper-MIP1 PF14389.6 KII67863.1 - 0.037 14.3 0.1 0.061 13.6 0.1 1.4 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 SIKE PF05769.11 KII67863.1 - 0.038 13.9 0.0 0.052 13.5 0.0 1.2 1 0 0 1 1 1 0 SIKE family HIGH_NTase1 PF05636.11 KII67863.1 - 0.14 11.3 0.2 0.16 11.1 0.2 1.0 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase PALP PF00291.25 KII67864.1 - 9.1e-18 64.7 0.0 1.2e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF5048 PF16467.5 KII67865.1 - 0.0074 16.6 0.7 0.0074 16.6 0.7 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5048) DUF2975 PF11188.8 KII67865.1 - 0.057 13.3 0.7 0.09 12.7 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) DUF3827 PF12877.7 KII67865.1 - 0.058 11.8 5.0 0.074 11.4 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) B12D PF06522.11 KII67865.1 - 0.15 11.9 0.4 0.25 11.2 0.4 1.3 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit UPF0258 PF06789.12 KII67865.1 - 0.99 9.5 6.6 1.6 8.8 6.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) KAP PF05804.12 KII67868.1 - 0.012 13.7 0.1 0.014 13.6 0.1 1.0 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) GIIM PF08388.11 KII67868.1 - 0.013 15.5 0.3 0.02 14.9 0.1 1.4 1 1 0 1 1 1 0 Group II intron, maturase-specific domain Kelch_6 PF13964.6 KII67869.1 - 3.4e-11 43.0 2.3 0.026 14.8 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 KII67869.1 - 8.5e-07 28.9 9.8 0.0066 16.4 0.5 4.5 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII67869.1 - 1.8e-06 27.4 1.7 0.37 10.4 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 KII67869.1 - 0.0003 20.6 0.1 1.1 9.3 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII67869.1 - 0.00049 20.3 3.6 3.9 7.9 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII67869.1 - 0.0021 18.0 0.1 0.024 14.6 0.0 2.6 2 0 0 2 2 2 1 Kelch motif 2OG-FeII_Oxy_2 PF13532.6 KII67870.1 - 0.11 12.7 1.9 0.15 12.2 0.7 1.7 1 1 1 2 2 2 0 2OG-Fe(II) oxygenase superfamily RT_RNaseH_2 PF17919.1 KII67871.1 - 5.5e-34 116.2 0.0 1.4e-33 114.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67871.1 - 1.7e-32 111.8 0.0 5.4e-32 110.2 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII67871.1 - 6e-21 75.0 0.0 1.2e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII67871.1 - 7.7e-20 71.3 0.0 3.6e-19 69.1 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67871.1 - 1.7e-17 63.3 0.0 4.5e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII67871.1 - 1.2e-06 29.0 0.0 2.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII67871.1 - 5.5e-05 23.7 0.0 0.00013 22.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII67871.1 - 0.00054 20.2 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.6 KII67871.1 - 0.0092 15.7 0.0 0.033 14.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain HypF_C PF17788.1 KII67871.1 - 0.13 13.0 0.0 1.2 9.8 0.0 2.4 2 0 0 2 2 2 0 HypF Kae1-like domain Galactosyl_T PF01762.21 KII67873.1 - 2.1e-09 37.5 0.1 2.6e-09 37.2 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase 6PF2K PF01591.18 KII67874.1 - 1.4e-60 204.4 4.5 2e-60 203.9 4.5 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KII67874.1 - 2.5e-10 40.4 0.0 3.9e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KII67874.1 - 8.7e-08 32.4 0.0 1.5e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 KII67874.1 - 0.0053 16.3 0.0 0.0094 15.4 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Vir_act_alpha_C PF10400.9 KII67874.1 - 0.037 14.7 0.0 0.12 13.1 0.0 1.8 1 0 0 1 1 1 0 Virulence activator alpha C-term Mnd1 PF03962.15 KII67874.1 - 0.074 13.3 0.2 0.48 10.7 0.1 2.4 3 0 0 3 3 3 0 Mnd1 HTH domain AAA_22 PF13401.6 KII67874.1 - 0.11 12.7 0.1 0.33 11.2 0.0 1.9 2 1 0 2 2 2 0 AAA domain CENP-B_dimeris PF09026.10 KII67876.1 - 0.0078 16.6 0.3 0.0099 16.3 0.3 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain FERM_N PF09379.10 KII67877.1 - 1.6e-06 27.9 0.1 2.5e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 FERM N-terminal domain TUG-UBL1 PF11470.8 KII67877.1 - 0.079 13.2 0.1 0.31 11.3 0.1 1.9 2 0 0 2 2 2 0 TUG ubiquitin-like domain YTH PF04146.15 KII67878.1 - 0.003 17.5 0.1 0.0034 17.4 0.1 1.1 1 0 0 1 1 1 1 YT521-B-like domain BrnA_antitoxin PF14384.6 KII67878.1 - 0.21 12.1 0.7 0.92 10.0 0.0 2.0 2 0 0 2 2 2 0 BrnA antitoxin of type II toxin-antitoxin system IPPT PF01715.17 KII67879.1 - 3.4e-53 180.8 0.1 4.9e-53 180.3 0.1 1.2 1 0 0 1 1 1 1 IPP transferase zf-C2H2_jaz PF12171.8 KII67879.1 - 1.9e-06 28.0 2.8 1.9e-06 28.0 2.8 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KII67879.1 - 6.7e-06 26.3 4.1 2.3e-05 24.6 4.1 2.0 1 0 0 1 1 1 1 Zinc-finger of C2H2 type IPT PF01745.16 KII67879.1 - 2.7e-05 23.7 0.0 0.0011 18.4 0.0 2.3 2 0 0 2 2 2 1 Isopentenyl transferase AAA_33 PF13671.6 KII67879.1 - 0.0013 18.9 0.0 0.014 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 KII67879.1 - 0.0079 16.3 0.0 0.017 15.2 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain OrsD PF12013.8 KII67879.1 - 0.031 14.7 0.2 0.083 13.3 0.2 1.7 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D IstB_IS21 PF01695.17 KII67879.1 - 0.037 13.8 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Hydin_ADK PF17213.3 KII67879.1 - 0.045 14.0 0.1 0.75 10.0 0.0 2.4 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain AAA_18 PF13238.6 KII67879.1 - 0.049 14.2 2.8 11 6.6 2.8 2.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 KII67879.1 - 0.085 13.3 0.0 0.23 11.9 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII67879.1 - 0.15 12.4 0.0 0.25 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain EZH2_WD-Binding PF11616.8 KII67881.1 - 0.077 13.1 0.8 0.17 12.0 0.1 1.9 2 0 0 2 2 2 0 WD repeat binding protein EZH2 HD PF01966.22 KII67882.1 - 1.5e-08 34.9 0.0 3.2e-08 33.8 0.0 1.7 1 1 0 1 1 1 1 HD domain PDEase_I PF00233.19 KII67882.1 - 0.0041 16.9 0.0 0.0086 15.8 0.0 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DDE_Tnp_IS1595 PF12762.7 KII67883.1 - 2.3e-17 63.4 0.0 3.9e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII67883.1 - 0.041 13.6 0.1 0.077 12.8 0.1 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease zf_ZIC PF18366.1 KII67883.1 - 0.094 12.8 0.7 0.6 10.3 0.9 2.1 2 0 0 2 2 2 0 Zic proteins zinc finger domain MRP-S31 PF15433.6 KII67884.1 - 3e-08 33.7 0.0 4.5e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 Nop14 PF04147.12 KII67885.1 - 4.2e-05 22.0 2.3 4.2e-05 22.0 2.3 1.5 2 0 0 2 2 2 1 Nop14-like family Nop14 PF04147.12 KII67887.1 - 8.3e-17 60.7 6.9 9.9e-17 60.5 6.9 1.0 1 0 0 1 1 1 1 Nop14-like family CHDCT2 PF08074.11 KII67887.1 - 0.064 13.4 1.4 0.078 13.1 1.4 1.2 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain DUF2247 PF10004.9 KII67887.1 - 0.42 10.4 6.8 0.61 9.9 6.5 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) DDE_Tnp_IS1595 PF12762.7 KII67888.1 - 0.00049 20.1 0.0 0.00097 19.2 0.0 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain YHYH PF14240.6 KII67888.1 - 0.00074 19.5 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 YHYH protein 7tm_1 PF00001.21 KII67889.1 - 5.6e-05 22.6 4.7 6.9e-05 22.3 4.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Syja_N PF02383.18 KII67890.1 - 1.9e-52 178.6 0.1 3.2e-52 177.8 0.1 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 KII67890.1 - 1.1e-10 41.5 0.1 2.2e-10 40.5 0.1 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FLYWCH PF04500.16 KII67891.1 - 0.045 13.9 1.3 0.11 12.7 1.3 1.7 1 0 0 1 1 1 0 FLYWCH zinc finger domain Prok-RING_1 PF14446.6 KII67891.1 - 0.074 13.0 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DDE_3 PF13358.6 KII67892.1 - 2.6e-27 95.4 0.0 3.4e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Acetyltransf_1 PF00583.25 KII67894.1 - 1.1e-14 54.7 0.1 1.6e-14 54.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII67894.1 - 1.2e-11 44.6 0.1 1.6e-11 44.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII67894.1 - 4.3e-08 33.5 0.0 8.3e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KII67894.1 - 4.6e-06 26.5 0.1 6.9e-06 25.9 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 KII67894.1 - 0.00038 20.6 0.7 0.0022 18.2 0.7 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 KII67894.1 - 0.0038 16.7 0.8 0.0059 16.1 0.8 1.6 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_3 PF13302.7 KII67894.1 - 0.0057 17.3 0.0 0.0081 16.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KII67894.1 - 0.017 15.2 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TT1725 PF18324.1 KII67894.1 - 0.033 14.3 0.0 0.063 13.4 0.0 1.5 1 0 0 1 1 1 0 Hypothetical protein TT1725 Acetyltransf_CG PF14542.6 KII67894.1 - 0.061 13.5 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 KII67894.1 - 0.16 12.0 0.1 0.35 10.9 0.1 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase DDE_Tnp_IS1595 PF12762.7 KII67896.1 - 6.4e-14 52.2 0.2 7.1e-14 52.1 0.2 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain IBN_N PF03810.19 KII67897.1 - 2e-06 27.6 0.3 0.00013 21.8 0.0 3.7 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT PF02985.22 KII67897.1 - 3e-06 27.0 1.6 0.01 16.0 0.0 5.7 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 KII67897.1 - 5.8e-06 26.7 0.3 0.061 13.8 0.1 4.0 4 0 0 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 KII67897.1 - 1.9e-05 24.7 1.3 1.9e-05 24.7 1.3 3.5 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KII67897.1 - 0.0003 21.1 0.0 4.5 7.7 0.0 3.6 3 0 0 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 KII67897.1 - 0.081 13.5 5.6 3.1 8.5 0.0 5.0 5 1 1 6 6 6 0 Vacuolar 14 Fab1-binding region IFRD PF05004.13 KII67897.1 - 0.12 11.5 7.1 5.6 6.0 0.0 4.0 4 1 0 4 4 4 0 Interferon-related developmental regulator (IFRD) DUF5131 PF07505.11 KII67897.1 - 0.14 11.6 0.1 2.3 7.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF5131) DUF3385 PF11865.8 KII67897.1 - 6.9 6.6 6.8 8.3 6.3 0.5 3.7 3 2 0 3 3 3 0 Domain of unknown function (DUF3385) DDE_Tnp_IS1595 PF12762.7 KII67898.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 ISXO2-like transposase domain DUF473 PF04322.12 KII67898.1 - 0.056 13.3 0.0 0.095 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF473) AFT PF08731.11 KII67898.1 - 0.083 13.3 0.1 0.14 12.6 0.1 1.3 1 0 0 1 1 1 0 Transcription factor AFT DUF4114 PF13448.6 KII67899.1 - 0.14 13.0 6.6 0.48 11.3 6.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4114) XRN_M PF17846.1 KII67899.1 - 0.44 9.4 9.6 0.52 9.2 9.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain SOBP PF15279.6 KII67899.1 - 0.57 10.7 12.8 0.67 10.5 12.8 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Pkinase PF00069.25 KII67900.1 - 1e-60 205.4 1.5 2.1e-60 204.3 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII67900.1 - 2.7e-29 102.3 0.1 2.7e-29 102.3 0.1 2.6 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 KII67900.1 - 8.3e-10 38.4 0.0 6.2e-09 35.6 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Rho_Binding PF08912.11 KII67900.1 - 3.1e-05 24.7 4.0 3.1e-05 24.7 4.0 9.9 4 3 5 10 10 10 1 Rho Binding C1_1 PF00130.22 KII67900.1 - 0.00013 21.8 8.6 0.00035 20.4 8.6 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Tropomyosin PF00261.20 KII67900.1 - 0.00041 19.8 14.7 0.00041 19.8 14.7 5.3 2 1 3 5 5 4 2 Tropomyosin PH PF00169.29 KII67900.1 - 0.014 15.9 1.3 11 6.6 0.0 3.9 4 0 0 4 4 4 0 PH domain APH PF01636.23 KII67900.1 - 0.016 15.2 0.0 0.051 13.5 0.1 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family OrfB_Zn_ribbon PF07282.11 KII67900.1 - 0.14 12.1 1.2 0.57 10.1 1.2 2.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain ApoO PF09769.9 KII67900.1 - 5.3 7.0 7.5 7.9 6.4 0.1 3.7 3 1 1 4 4 4 0 Apolipoprotein O SlyX PF04102.12 KII67900.1 - 6.2 7.5 56.2 1.8 9.2 2.5 9.0 5 3 5 10 10 10 0 SlyX DDE_3 PF13358.6 KII67907.1 - 1.1e-07 31.6 0.4 2.2e-07 30.7 0.4 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease PDZ PF00595.24 KII67908.1 - 1.9e-10 40.9 0.4 3.9e-10 39.9 0.4 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII67908.1 - 0.00015 21.5 0.0 0.00024 20.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII67908.1 - 0.0055 17.0 0.1 0.0096 16.2 0.1 1.4 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 KII67910.1 - 1.1e-30 105.6 39.0 8.7e-12 45.1 5.9 3.1 3 0 0 3 3 3 3 LIM domain zf-RING_6 PF14835.6 KII67910.1 - 0.012 15.5 1.9 0.012 15.5 1.9 3.3 2 2 1 3 3 3 0 zf-RING of BARD1-type protein LIM PF00412.22 KII67911.1 - 5.8e-28 96.9 47.9 3.8e-11 43.0 11.4 3.2 3 0 0 3 3 3 3 LIM domain PDZ_6 PF17820.1 KII67911.1 - 2e-06 27.6 0.1 3.2e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII67911.1 - 0.00053 20.3 0.0 0.0021 18.3 0.1 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KII67911.1 - 0.031 14.6 0.1 0.081 13.3 0.1 1.7 1 0 0 1 1 1 0 PDZ domain DDE_1 PF03184.19 KII67912.1 - 6.1e-08 32.5 0.1 1.3e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease LacI PF00356.21 KII67913.1 - 0.0002 21.1 0.0 0.00036 20.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family ATP_bind_1 PF03029.17 KII67914.1 - 1.4e-34 119.9 0.1 1.7e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein RNA_pol PF00940.19 KII67915.1 - 1.2e-102 343.8 0.6 1.2e-102 343.8 0.6 1.6 2 0 0 2 2 2 1 DNA-dependent RNA polymerase DUF4373 PF14297.6 KII67915.1 - 0.44 11.4 2.2 30 5.5 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4373) Surp PF01805.20 KII67916.1 - 8.6e-18 64.1 4.3 1.9e-17 63.0 0.3 3.1 3 0 0 3 3 3 1 Surp module RRM_1 PF00076.22 KII67916.1 - 2.2e-08 33.8 0.0 1.3e-07 31.3 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 KII67916.1 - 2.4e-05 25.1 0.3 8e-05 23.4 0.3 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CTK3 PF12243.8 KII67916.1 - 0.0053 16.7 0.4 0.013 15.5 0.4 1.6 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 IBP39 PF11422.8 KII67916.1 - 0.036 13.8 1.1 3.4 7.4 0.2 3.3 3 1 0 3 3 3 0 Initiator binding protein 39 kDa Xpo1 PF08389.12 KII67916.1 - 0.16 12.0 2.2 0.87 9.6 0.3 2.4 2 0 0 2 2 2 0 Exportin 1-like protein DUF1216 PF06746.11 KII67916.1 - 1.7 8.7 6.9 0.3 11.1 0.6 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1216) Elong-fact-P_C PF09285.11 KII67918.1 - 1.3e-26 92.1 0.5 3.4e-26 90.8 0.5 1.7 1 0 0 1 1 1 1 Elongation factor P, C-terminal EFP_N PF08207.12 KII67918.1 - 3.4e-24 84.6 0.0 1.2e-23 82.9 0.0 1.9 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain EFP PF01132.20 KII67918.1 - 5.7e-22 77.5 0.0 1.2e-21 76.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain Radical_SAM PF04055.21 KII67919.1 - 4.4e-08 33.7 0.1 2.2e-07 31.4 0.0 2.1 2 1 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 KII67919.1 - 7.3e-07 29.5 0.0 2e-06 28.1 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 KII67919.1 - 6.8e-06 26.2 0.0 1.2e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPOC PF07744.13 KII67919.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 SPOC domain Trans_reg_C PF00486.28 KII67920.1 - 3.7e-14 52.6 0.0 6e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Attacin_N PF03768.15 KII67921.1 - 1.8 8.7 11.1 1.4 9.1 1.8 2.7 3 0 0 3 3 3 0 Attacin, N-terminal region PapD_N PF00345.20 KII67922.1 - 3.7e-36 123.8 0.2 6.1e-36 123.1 0.2 1.3 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain PapD_C PF02753.17 KII67922.1 - 9.4e-07 29.1 1.1 4.9e-06 26.8 0.3 2.7 3 1 0 3 3 3 1 Pili assembly chaperone PapD, C-terminal domain GerPE PF10970.8 KII67922.1 - 0.086 13.0 0.5 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 Spore germination protein GerPE Usher PF00577.20 KII67923.1 - 2.1e-186 621.0 23.7 2.8e-186 620.6 23.7 1.1 1 0 0 1 1 1 1 Outer membrane usher protein PapC_N PF13954.6 KII67923.1 - 1.2e-36 125.9 0.1 2.5e-36 124.9 0.1 1.5 1 0 0 1 1 1 1 PapC N-terminal domain PapC_C PF13953.6 KII67923.1 - 3.1e-17 62.2 0.1 6.9e-17 61.0 0.1 1.6 1 0 0 1 1 1 1 PapC C-terminal domain Fimbrial PF00419.20 KII67924.1 - 1.5e-12 48.0 3.3 3.1e-12 47.0 1.1 2.0 2 0 0 2 2 2 1 Fimbrial protein Rick_17kDa_Anti PF05433.15 KII67925.1 - 0.042 13.7 19.3 0.2 11.5 11.6 2.5 2 0 0 2 2 2 0 Glycine zipper 2TM domain TraT PF05818.12 KII67925.1 - 0.13 11.9 6.9 0.16 11.6 6.9 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Gly-zipper_YMGG PF13441.6 KII67925.1 - 1.9 8.3 21.6 7.4 6.4 21.6 2.0 1 1 0 1 1 1 0 YMGG-like Gly-zipper HlyD_3 PF13437.6 KII67926.1 - 2.4e-15 57.1 0.5 1e-10 42.2 0.0 2.6 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 KII67926.1 - 2.7e-13 49.6 0.5 5.7e-08 32.2 0.1 2.3 2 0 0 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 KII67926.1 - 6e-13 48.4 2.5 3.7e-06 26.7 0.1 3.2 3 0 0 3 3 3 2 Biotin-lipoyl like HlyD PF00529.20 KII67926.1 - 4.4e-10 39.3 0.0 6.1e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl PF00364.22 KII67926.1 - 1.9e-07 30.8 1.0 0.0082 16.0 0.3 2.8 2 0 0 2 2 2 2 Biotin-requiring enzyme RraB PF06877.11 KII67926.1 - 0.0014 19.3 2.4 0.0034 18.1 1.0 2.3 1 1 0 2 2 2 1 Regulator of ribonuclease activity B zf-C4H2 PF10146.9 KII67926.1 - 0.0073 16.6 6.8 0.012 15.9 6.8 1.3 1 0 0 1 1 1 1 Zinc finger-containing protein Seryl_tRNA_N PF02403.22 KII67926.1 - 0.0089 16.3 4.8 0.0089 16.3 4.8 2.3 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DUF2153 PF09921.9 KII67926.1 - 0.013 15.3 1.3 0.031 14.1 1.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) IceA2 PF05862.11 KII67926.1 - 0.027 14.4 0.2 0.1 12.5 0.2 2.0 1 0 0 1 1 1 0 Helicobacter pylori IceA2 protein PTS_EIIA_1 PF00358.20 KII67926.1 - 0.034 13.9 0.2 1.1 9.0 0.0 2.5 2 0 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 TBCA PF02970.16 KII67926.1 - 0.04 14.3 1.4 0.04 14.3 1.4 1.9 2 0 0 2 2 2 0 Tubulin binding cofactor A ALMT PF11744.8 KII67926.1 - 0.083 11.7 12.0 0.13 11.1 12.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter YnfE PF17452.2 KII67926.1 - 0.16 12.3 4.8 1.6 9.1 0.4 3.1 2 1 1 3 3 3 0 Uncharacterized YnfE-like DUF2935 PF11155.8 KII67926.1 - 0.27 11.6 6.6 0.26 11.6 1.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) ApoLp-III PF07464.11 KII67926.1 - 0.58 10.2 17.9 0.23 11.6 14.4 1.9 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Exonuc_VII_L PF02601.15 KII67926.1 - 0.74 9.3 8.9 1.2 8.6 8.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_M23 PF01551.22 KII67926.1 - 1.3 9.3 9.2 2.3 8.5 0.6 3.7 2 1 2 5 5 5 0 Peptidase family M23 DUF1043 PF06295.12 KII67926.1 - 3 7.9 16.6 3.1 7.8 11.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) AvrM-A PF18241.1 KII67926.1 - 3.9 7.9 10.4 8.7 6.7 0.3 2.7 1 1 0 2 2 2 0 Flax-rust effector AvrM-A ABC_tran PF00005.27 KII67927.1 - 1.1e-30 106.9 0.0 1.7e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KII67927.1 - 1.2e-18 67.7 1.3 2e-18 67.0 1.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 KII67927.1 - 6.7e-06 25.7 0.1 0.00019 20.9 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KII67927.1 - 0.00023 20.9 0.1 0.00054 19.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 KII67927.1 - 0.00027 20.8 0.2 0.035 13.9 0.2 2.2 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 KII67927.1 - 0.00039 20.8 0.4 0.0074 16.7 0.4 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KII67927.1 - 0.0023 17.9 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase Mg_chelatase PF01078.21 KII67927.1 - 0.0039 16.6 0.0 0.0089 15.4 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KII67927.1 - 0.0082 16.5 0.0 0.015 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KII67927.1 - 0.0099 16.1 0.3 0.039 14.2 0.2 1.9 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 KII67927.1 - 0.027 14.2 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KII67927.1 - 0.04 13.9 0.1 0.14 12.2 0.1 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 KII67927.1 - 0.052 13.6 0.1 0.1 12.7 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 KII67927.1 - 0.059 13.9 0.1 0.098 13.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KII67927.1 - 0.083 13.4 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KII67927.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KII67927.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 KII67927.1 - 0.14 12.2 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Roc PF08477.13 KII67927.1 - 0.14 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 KII67927.1 - 0.27 11.1 1.4 0.39 10.6 0.2 1.9 3 0 0 3 3 2 0 NACHT domain YjeJ PF15922.5 KII67928.1 - 1.6e-80 270.4 4.7 1.8e-80 270.2 4.7 1.0 1 0 0 1 1 1 1 YjeJ-like CdiA_C PF18451.1 KII67928.1 - 1.3 9.3 5.4 0.73 10.1 0.4 2.9 3 1 1 4 4 4 0 Contact-dependent growth inhibition CdiA C-terminal domain DUF4156 PF13698.6 KII67929.1 - 2e-31 108.2 0.3 3.3e-31 107.4 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4156) Cpn60_TCP1 PF00118.24 KII67929.1 - 0.00012 20.9 0.0 0.00016 20.4 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 KII67930.1 - 6.2e-60 203.2 11.3 1.2e-59 202.3 11.3 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cyclin_N PF00134.23 KII67931.1 - 0.041 13.6 0.6 0.1 12.4 0.1 1.9 2 1 1 3 3 3 0 Cyclin, N-terminal domain IpaB_EvcA PF03278.13 KII67933.1 - 0.02 14.6 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 IpaB/EvcA family MCM2_N PF12619.8 KII67939.1 - 0.05 13.9 0.1 0.064 13.5 0.1 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance protein 2 EZH2_N PF18601.1 KII67940.1 - 0.0017 18.6 0.8 0.0029 17.9 0.1 1.7 2 0 0 2 2 2 1 EZH2 N-terminal domain MerT PF02411.15 KII67941.1 - 0.016 15.2 0.2 0.023 14.7 0.2 1.3 1 0 0 1 1 1 0 MerT mercuric transport protein SecD-TM1 PF13721.6 KII67941.1 - 0.82 10.2 0.0 0.82 10.2 0.0 2.4 2 1 1 3 3 3 0 SecD export protein N-terminal TM region DUF1837 PF08878.11 KII67942.1 - 0.042 13.6 0.0 0.046 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1837) Sod_Cu PF00080.20 KII67943.1 - 1.6e-30 106.1 0.1 2.1e-30 105.8 0.1 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Serpin PF00079.20 KII67944.1 - 1.2e-44 153.2 0.2 1.3e-44 153.0 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) IceA2 PF05862.11 KII67944.1 - 0.069 13.1 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Helicobacter pylori IceA2 protein HTH_32 PF13565.6 KII67947.1 - 5.6e-05 23.7 0.0 0.075 13.7 0.0 2.2 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 KII67947.1 - 0.0063 16.3 0.0 0.038 13.8 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 KII67947.1 - 0.05 13.2 0.2 0.089 12.4 0.2 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Gp-FAR-1 PF05823.12 KII67947.1 - 0.062 13.7 0.2 0.12 12.7 0.2 1.5 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) ApoLp-III PF07464.11 KII67947.1 - 0.072 13.2 0.0 0.088 12.9 0.0 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) TrmB PF01978.19 KII67947.1 - 0.077 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF1323 PF07037.11 KII67947.1 - 0.094 13.1 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) HTH_17 PF12728.7 KII67947.1 - 0.12 12.6 0.0 0.27 11.4 0.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain UvdE PF03851.14 KII67948.1 - 0.054 12.7 0.0 0.079 12.2 0.0 1.2 1 0 0 1 1 1 0 UV-endonuclease UvdE CARD PF00619.21 KII67948.1 - 0.13 12.3 0.2 1 9.4 0.0 2.5 3 0 0 3 3 3 0 Caspase recruitment domain Sod_Cu PF00080.20 KII67956.1 - 4.9e-28 98.1 0.1 6.2e-28 97.8 0.1 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Sod_Cu PF00080.20 KII67957.1 - 7.8e-37 126.6 0.4 1.1e-36 126.1 0.4 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Sod_Cu PF00080.20 KII67958.1 - 3.7e-36 124.4 0.1 4.4e-36 124.2 0.1 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) VASt PF16016.5 KII67960.1 - 0.05 14.0 0.1 0.06 13.7 0.1 1.2 1 0 0 1 1 1 0 VAD1 Analog of StAR-related lipid transfer domain KOW PF00467.29 KII67961.1 - 0.0088 16.0 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 KOW motif HTH_Tnp_IS630 PF01710.16 KII67962.1 - 0.0012 18.9 0.3 0.0016 18.5 0.3 1.4 1 1 0 1 1 1 1 Transposase HTH_23 PF13384.6 KII67962.1 - 0.0015 18.3 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.18 KII67962.1 - 0.0021 18.0 0.0 0.0026 17.7 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_28 PF13518.6 KII67962.1 - 0.062 13.4 0.0 0.098 12.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 KII67962.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain MLVIN_C PF18697.1 KII67963.1 - 0.043 13.9 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain AT_hook PF02178.19 KII67963.1 - 3.6 7.8 8.9 8 6.7 8.9 1.5 1 0 0 1 1 1 0 AT hook motif GDPD PF03009.17 KII67964.1 - 2.2e-48 165.2 0.0 3.2e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DDE_Tnp_IS1595 PF12762.7 KII67965.1 - 2.9e-17 63.1 0.0 3.9e-17 62.7 0.0 1.2 1 1 0 1 1 1 1 ISXO2-like transposase domain Peptidase_C1 PF00112.23 KII67966.1 - 9.3e-67 225.3 0.3 1.2e-66 224.9 0.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII67966.1 - 3.2e-11 43.5 0.8 5.4e-11 42.8 0.8 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KII67966.1 - 1.7e-05 23.8 0.2 0.00029 19.7 0.1 2.1 2 0 0 2 2 2 1 Peptidase C1-like family PI3_PI4_kinase PF00454.27 KII67967.1 - 1e-35 123.8 0.0 1.2e-35 123.5 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase START PF01852.19 KII67969.1 - 8e-19 67.9 0.0 9.9e-19 67.6 0.0 1.1 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 KII67969.1 - 0.055 13.4 0.1 0.2 11.6 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) Na_H_Exchanger PF00999.21 KII67970.1 - 2.1e-46 158.4 31.8 4.4e-46 157.4 31.8 1.4 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family DUF1223 PF06764.11 KII67971.1 - 0.084 12.9 0.3 0.11 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) DUF2753 PF10952.8 KII67975.1 - 0.02 15.0 0.1 0.069 13.3 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2753) AalphaY_MDB PF04611.12 KII67978.1 - 0.019 15.0 0.0 0.024 14.6 0.0 1.2 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region YnfE PF17452.2 KII67978.1 - 0.1 12.9 0.0 0.32 11.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized YnfE-like DUF3759 PF12585.8 KII67979.1 - 0.0053 16.8 0.0 3.1 7.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3759) HTH_56 PF18662.1 KII67981.1 - 0.012 15.6 0.7 0.06 13.4 0.0 2.4 3 0 0 3 3 3 0 Cch helix turn helix domain DUF3179 PF11376.8 KII67981.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3179) Retrotrans_gag PF03732.17 KII67983.1 - 0.0099 16.1 0.0 0.018 15.3 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon gag protein RT_RNaseH PF17917.1 KII67984.1 - 3.2e-33 114.1 0.1 6.2e-33 113.2 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII67984.1 - 1.2e-24 86.2 0.0 2.1e-24 85.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII67984.1 - 4.2e-16 58.8 0.1 9e-16 57.7 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII67984.1 - 6.1e-08 32.7 0.0 1.2e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger rve PF00665.26 KII67984.1 - 0.0002 21.5 0.2 0.00075 19.7 0.1 2.0 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 KII67985.1 - 1.1e-21 77.4 0.0 1.4e-21 77.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII67986.1 - 1.8e-05 24.6 0.6 1.8e-05 24.6 0.6 2.6 2 0 0 2 2 2 1 Zinc knuckle RVP PF00077.20 KII67986.1 - 0.001 19.3 0.0 0.0032 17.8 0.0 1.8 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII67986.1 - 0.0068 16.9 0.0 0.046 14.3 0.0 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII67986.1 - 0.011 16.3 0.0 0.066 13.9 0.0 2.3 2 1 0 2 2 2 0 Aspartyl protease Spuma_A9PTase PF03539.14 KII67986.1 - 0.03 14.5 0.0 0.06 13.5 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) DUF5384 PF17358.2 KII67986.1 - 0.057 13.5 2.9 0.1 12.7 2.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5384) LXG PF04740.12 KII67986.1 - 0.12 12.1 3.4 0.57 9.9 1.1 2.1 2 0 0 2 2 2 0 LXG domain of WXG superfamily zf-CCHC_4 PF14392.6 KII67986.1 - 0.13 12.0 12.4 0.61 9.9 1.2 2.5 1 1 1 2 2 2 0 Zinc knuckle DUF4211 PF13926.6 KII67986.1 - 0.34 11.0 4.3 0.76 9.8 4.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4211) RT_RNaseH_2 PF17919.1 KII67988.1 - 1.3e-34 118.2 0.0 2.6e-34 117.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII67988.1 - 6.4e-33 113.2 0.0 1.3e-32 112.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase AFG1_ATPase PF03969.16 KII67988.1 - 1.3e-26 93.3 0.0 2.3e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 AFG1-like ATPase rve PF00665.26 KII67988.1 - 3.6e-18 65.9 0.0 1.2e-17 64.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII67988.1 - 1.1e-14 54.2 0.2 2.5e-14 53.1 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII67988.1 - 3.6e-10 39.7 0.0 7.1e-09 35.5 0.0 2.6 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_16 PF13191.6 KII67988.1 - 4.8e-05 23.8 0.0 0.0049 17.3 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain zf-H2C2 PF09337.10 KII67988.1 - 0.00027 21.1 0.5 0.00067 19.8 0.5 1.7 1 0 0 1 1 1 1 H2C2 zinc finger AAA_22 PF13401.6 KII67988.1 - 0.0019 18.5 0.0 0.0052 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KII67988.1 - 0.0019 18.5 0.0 3.1 8.1 0.0 2.4 1 1 0 2 2 2 2 AAA domain rve_3 PF13683.6 KII67988.1 - 0.0029 17.4 0.0 0.0078 16.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain IstB_IS21 PF01695.17 KII67988.1 - 0.069 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.29 KII67988.1 - 0.074 13.5 0.0 0.3 11.5 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KII67988.1 - 0.11 12.2 0.0 4.6 6.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain AFG1_ATPase PF03969.16 KII67989.1 - 5.4e-12 45.3 0.1 6.1e-12 45.1 0.1 1.1 1 0 0 1 1 1 1 AFG1-like ATPase Aldo_ket_red PF00248.21 KII67991.1 - 1.5e-37 129.4 0.0 2e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Intron_maturas2 PF01348.21 KII67991.1 - 0.044 13.8 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Type II intron maturase MaoC_dehydratas PF01575.19 KII67994.1 - 0.035 13.7 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 MaoC like domain RRM_1 PF00076.22 KII67995.1 - 2.8e-21 75.1 0.0 4.3e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 KII67995.1 - 0.0083 16.4 0.1 0.012 15.9 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter BRAP2 PF07576.12 KII67995.1 - 0.11 12.7 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 BRCA1-associated protein 2 Na_K-ATPase PF00287.18 KII67997.1 - 3e-07 29.9 3.9 1.5e-05 24.3 0.6 2.6 1 1 1 2 2 2 2 Sodium / potassium ATPase beta chain DUF1320 PF07030.12 KII67997.1 - 0.088 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) Zip PF02535.22 KII67999.1 - 8e-50 169.9 12.9 5.7e-48 163.8 12.9 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter HTH_33 PF13592.6 KII68000.1 - 5.5e-05 22.7 0.0 0.00023 20.7 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix p25-alpha PF05517.12 KII68000.1 - 0.0046 17.1 0.6 0.01 16.0 0.2 1.8 1 1 1 2 2 2 1 p25-alpha DHquinase_II PF01220.19 KII68000.1 - 0.12 12.1 0.4 0.22 11.2 0.4 1.4 1 0 0 1 1 1 0 Dehydroquinase class II Nmad5 PF18757.1 KII68001.1 - 0.86 9.8 7.0 1.2 9.3 7.0 1.1 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 HTH_33 PF13592.6 KII68003.1 - 2.4e-07 30.3 0.1 4.3e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 KII68003.1 - 5.1e-05 23.8 0.1 6.7e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII68003.1 - 0.00012 22.3 0.0 0.00024 21.3 0.0 1.6 1 0 0 1 1 1 1 Transposase HTH_DeoR PF08220.12 KII68003.1 - 0.03 14.1 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_Tnp_1_2 PF13022.6 KII68003.1 - 0.06 13.5 0.1 0.085 13.0 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_AsnC-type PF13404.6 KII68003.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain DDE_Tnp_IS1595 PF12762.7 KII68004.1 - 0.00013 22.0 0.1 0.00052 20.0 0.1 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain DJ-1_PfpI PF01965.24 KII68005.1 - 2.3e-05 24.3 0.0 9.8e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family EamA PF00892.20 KII68006.1 - 2.2 8.5 12.0 0.053 13.7 4.2 2.2 3 0 0 3 3 3 0 EamA-like transporter family EamA PF00892.20 KII68007.1 - 0.01 16.0 10.5 0.01 16.0 10.5 1.7 2 0 0 2 2 2 1 EamA-like transporter family DUF3671 PF12420.8 KII68007.1 - 3.1 7.9 10.0 1.7e+02 2.3 6.0 3.1 2 1 0 2 2 2 0 Protein of unknown function Ca_hom_mod PF14798.6 KII68008.1 - 9.8e-05 21.6 4.0 0.13 11.3 0.0 2.2 1 1 1 2 2 2 2 Calcium homeostasis modulator Arif-1 PF06770.11 KII68008.1 - 0.0073 16.0 0.8 0.016 14.9 0.1 1.8 2 0 0 2 2 2 1 Actin-rearrangement-inducing factor (Arif-1) AceK PF06315.11 KII68008.1 - 0.011 14.3 0.1 0.016 13.7 0.1 1.2 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) EptA_B_N PF08019.12 KII68008.1 - 0.042 13.7 2.8 0.13 12.1 0.3 2.2 2 1 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB DUF3708 PF12501.8 KII68008.1 - 0.16 11.7 0.6 0.59 9.9 0.7 1.8 1 1 1 2 2 2 0 Phosphate ATP-binding cassette transporter DHHC PF01529.20 KII68008.1 - 1.8 8.7 6.6 2.5 8.2 2.1 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF2207 PF09972.9 KII68008.1 - 1.9 7.2 4.7 0.5 9.1 1.5 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF1280 PF06918.14 KII68009.1 - 0.045 13.3 0.7 0.89 9.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1280) PmrD PF11183.8 KII68009.1 - 0.049 13.8 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Polymyxin resistance protein PmrD YdjO PF14169.6 KII68009.1 - 0.097 12.4 0.1 0.097 12.4 0.1 2.2 3 0 0 3 3 3 0 Cold-inducible protein YdjO RVT_1 PF00078.27 KII68010.1 - 5.9e-23 81.6 0.0 1.1e-22 80.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII68010.1 - 6.6e-17 61.8 0.0 1.5e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII68010.1 - 0.00014 21.5 0.2 0.00047 19.9 0.2 2.0 1 0 0 1 1 1 1 Integrase core domain zf-C2H2_10 PF16588.5 KII68010.1 - 0.017 14.8 1.5 0.044 13.5 1.5 1.7 1 0 0 1 1 1 0 C2H2 zinc-finger zf-CCHC PF00098.23 KII68010.1 - 0.034 14.2 1.0 0.034 14.2 1.0 2.3 2 0 0 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 KII68010.1 - 0.037 14.7 0.0 0.12 13.0 0.0 1.9 2 0 0 2 2 1 0 Aspartyl protease Retrotrans_gag PF03732.17 KII68010.1 - 0.042 14.1 0.6 0.94 9.8 0.0 3.2 3 0 0 3 3 3 0 Retrotransposon gag protein gag-asp_proteas PF13975.6 KII68010.1 - 0.044 14.3 0.0 0.12 13.0 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Agenet PF05641.12 KII68010.1 - 0.12 12.8 0.2 37 4.9 0.0 2.7 2 0 0 2 2 2 0 Agenet domain RVP PF00077.20 KII68010.1 - 0.13 12.6 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease ZT_dimer PF16916.5 KII68010.1 - 0.4 10.8 3.3 2.6 8.2 0.1 3.1 3 0 0 3 3 3 0 Dimerisation domain of Zinc Transporter HTH_32 PF13565.6 KII68011.1 - 5.5e-06 26.9 0.8 0.027 15.1 0.1 2.2 2 0 0 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 KII68011.1 - 7.8e-06 25.5 0.2 0.00024 20.8 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.18 KII68011.1 - 1.4e-05 25.0 0.2 1.9e-05 24.6 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_ISL3 PF13542.6 KII68011.1 - 6.9e-05 22.2 0.1 0.0003 20.1 0.0 2.0 2 1 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_33 PF13592.6 KII68011.1 - 0.00018 21.0 0.0 0.00059 19.4 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 KII68011.1 - 0.0003 20.5 0.2 0.0003 20.5 0.2 2.1 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_24 PF13412.6 KII68011.1 - 0.0007 19.1 0.1 0.0067 16.0 0.0 2.3 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding CENP-B_N PF04218.13 KII68011.1 - 0.0015 18.2 0.1 0.0034 17.0 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain MarR_2 PF12802.7 KII68011.1 - 0.0037 17.1 0.0 0.0083 16.0 0.0 1.6 2 0 0 2 2 2 1 MarR family HTH_3 PF01381.22 KII68011.1 - 0.0052 16.8 0.1 0.025 14.6 0.0 2.1 2 1 0 2 2 2 1 Helix-turn-helix IL6 PF00489.17 KII68011.1 - 0.009 15.6 0.4 0.012 15.2 0.4 1.2 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family MetOD1 PF18546.1 KII68011.1 - 0.016 15.2 0.2 0.047 13.7 0.0 1.7 2 0 0 2 2 2 0 Metanogen output domain 1 Sigma70_r4 PF04545.16 KII68011.1 - 0.025 14.1 0.2 0.059 12.9 0.1 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 Mnd1 PF03962.15 KII68011.1 - 0.029 14.7 0.0 0.061 13.6 0.0 1.5 1 0 0 1 1 1 0 Mnd1 HTH domain IPPT PF01715.17 KII68011.1 - 0.036 13.9 0.5 0.037 13.8 0.5 1.1 1 0 0 1 1 1 0 IPP transferase HTH_28 PF13518.6 KII68011.1 - 0.039 14.1 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_17 PF12728.7 KII68011.1 - 0.043 14.0 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain DUF1323 PF07037.11 KII68011.1 - 0.05 14.0 0.2 0.29 11.5 0.0 1.9 1 1 1 2 2 2 0 Putative transcription regulator (DUF1323) Complex1_LYR_1 PF13232.6 KII68011.1 - 0.084 13.5 0.0 0.29 11.7 0.0 1.8 1 1 1 2 2 2 0 Complex1_LYR-like Retrotrans_gag PF03732.17 KII68012.1 - 0.0033 17.7 0.0 0.0058 16.9 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein Toprim_N PF08275.11 KII68012.1 - 0.01 15.8 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 0 DNA primase catalytic core, N-terminal domain GrpE PF01025.19 KII68016.1 - 0.0083 15.8 0.8 0.017 14.8 0.8 1.4 1 0 0 1 1 1 1 GrpE SH3_2 PF07653.17 KII68016.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SSFA2_C PF14723.6 KII68016.1 - 0.071 13.0 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Sperm-specific antigen 2 C-terminus IFT81_CH PF18383.1 KII68016.1 - 0.11 12.8 3.0 10 6.4 0.2 2.6 3 0 0 3 3 3 0 Intraflagellar transport 81 calponin homology domain HAD_2 PF13419.6 KII68016.1 - 0.17 11.9 1.1 0.26 11.3 0.1 1.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase AKAP95 PF04988.12 KII68017.1 - 1.2e-05 25.6 5.1 0.0027 18.0 0.0 2.5 1 1 0 2 2 2 2 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.12 KII68017.1 - 1.5 8.7 4.9 1.3 8.9 0.2 2.7 2 0 0 2 2 2 0 U1 zinc finger DUF3449 PF11931.8 KII68017.1 - 1.7 8.4 5.5 11 5.7 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3449) HTH_23 PF13384.6 KII68018.1 - 0.0041 16.9 0.0 0.009 15.8 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 KII68018.1 - 0.036 14.7 0.0 0.14 12.8 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 KII68018.1 - 0.097 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Bombinin PF05298.11 KII68018.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Bombinin CPSase_L_D2 PF02786.17 KII68019.1 - 3e-64 216.4 0.1 3.3e-64 216.3 0.1 1.0 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 KII68019.1 - 2.2e-06 27.3 0.0 3.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.11 KII68019.1 - 0.00053 19.6 0.0 0.00073 19.2 0.0 1.4 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp PF02222.22 KII68019.1 - 0.0012 18.4 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 KII68019.1 - 0.1 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_carb_N PF00289.22 KII68020.1 - 2.4e-35 121.4 0.0 3.1e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain EF-hand_13 PF17958.1 KII68020.1 - 0.21 11.4 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain DUF4149 PF13664.6 KII68021.1 - 0.061 13.6 2.8 0.55 10.6 0.0 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4149) MscS_TM PF12794.7 KII68021.1 - 0.58 9.0 2.5 9.4 5.0 0.1 3.0 3 0 0 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 Hist_deacetyl PF00850.19 KII68022.1 - 7.3e-83 278.6 0.0 9.9e-83 278.1 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DUF2524 PF10732.9 KII68023.1 - 0.031 14.6 0.6 0.46 10.8 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) Bap31_Bap29_C PF18035.1 KII68023.1 - 0.046 13.7 5.3 0.12 12.4 4.8 2.1 1 1 1 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain CC2D2AN-C2 PF15625.6 KII68023.1 - 0.095 12.4 0.8 0.16 11.7 0.8 1.4 1 0 0 1 1 1 0 CC2D2A N-terminal C2 domain CS PF04969.16 KII68024.1 - 0.0021 19.0 0.2 0.0031 18.5 0.2 1.3 1 0 0 1 1 1 1 CS domain Aa_trans PF01490.18 KII68025.1 - 7e-59 199.6 32.7 8.1e-59 199.4 32.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein V_ATPase_I PF01496.19 KII68026.1 - 0.00014 19.9 0.0 0.00015 19.8 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SHMT PF00464.19 KII68027.1 - 2.4e-176 586.2 0.0 2.8e-176 586.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Coat_F PF07875.12 KII68027.1 - 0.031 14.5 0.2 0.13 12.5 0.0 2.1 2 0 0 2 2 2 0 Coat F domain HisKA PF00512.25 KII68027.1 - 0.12 12.4 0.1 2.1 8.4 0.0 2.4 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain V_ATPase_I PF01496.19 KII68028.1 - 2.8e-173 577.9 11.2 7.7e-173 576.5 11.2 1.5 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family FlaC_arch PF05377.11 KII68028.1 - 0.27 11.7 3.1 5.8 7.4 0.1 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) MULE PF10551.9 KII68029.1 - 3.9e-07 30.4 0.0 5.7e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 MULE transposase domain Arfaptin PF06456.13 KII68030.1 - 5.7e-37 127.5 13.2 8e-37 127.0 13.2 1.1 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.24 KII68030.1 - 2.4e-13 50.2 0.0 5.2e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII68030.1 - 2.6e-11 43.2 0.0 5.5e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII68030.1 - 1.3e-05 25.4 0.0 2.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain BAR_3 PF16746.5 KII68030.1 - 0.00072 19.3 12.0 0.043 13.5 1.1 2.3 2 0 0 2 2 2 2 BAR domain of APPL family AA_permease_2 PF13520.6 KII68031.1 - 1.4e-16 60.4 28.5 1.8e-16 60.0 28.5 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KII68032.1 - 6.4e-18 64.8 24.4 7.3e-18 64.6 24.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KII68032.1 - 4e-08 32.3 23.2 4.5e-08 32.1 23.2 1.0 1 0 0 1 1 1 1 Amino acid permease WTF PF03303.13 KII68032.1 - 0.35 10.5 8.5 0.54 10.0 8.5 1.3 1 0 0 1 1 1 0 WTF protein MutS_V PF00488.21 KII68033.1 - 7.6e-67 225.0 0.1 2.6e-66 223.2 0.1 1.9 2 0 0 2 2 2 1 MutS domain V MutS_I PF01624.20 KII68033.1 - 1.1e-30 106.1 0.0 2.9e-30 104.8 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 KII68033.1 - 1.6e-26 93.8 0.2 5.1e-26 92.1 0.2 1.9 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 KII68033.1 - 4.8e-15 55.7 0.5 4.8e-15 55.7 0.5 2.4 3 0 0 3 3 3 1 MutS family domain IV AAA_29 PF13555.6 KII68033.1 - 0.12 12.2 0.1 0.27 11.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pax7 PF12360.8 KII68034.1 - 0.029 14.6 0.1 0.3 11.3 0.0 2.2 2 0 0 2 2 2 0 Paired box protein 7 Mito_carr PF00153.27 KII68038.1 - 2.8e-22 78.4 1.8 5.6e-06 26.2 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein Rad21_Rec8_N PF04825.13 KII68039.1 - 9.2e-25 87.0 0.0 1.7e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 KII68039.1 - 0.00053 19.2 0.0 0.0011 18.2 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 KII68039.1 - 0.0065 16.4 0.1 0.021 14.7 0.0 1.9 3 0 0 3 3 3 1 Segregation and condensation protein ScpA DUF3656 PF12392.8 KII68039.1 - 0.023 15.4 0.2 0.046 14.4 0.2 1.5 1 0 0 1 1 1 0 Collagenase HAD_2 PF13419.6 KII68039.1 - 0.025 14.7 0.0 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HEPN_RES_NTD1 PF18870.1 KII68040.1 - 0.0021 18.3 0.6 0.0032 17.7 0.6 1.3 1 0 0 1 1 1 1 HEPN/RES N-terminal domain 1 PP2C_C PF07830.13 KII68040.1 - 0.15 12.5 0.0 0.3 11.6 0.0 1.4 1 1 0 1 1 1 0 Protein serine/threonine phosphatase 2C, C-terminal domain SpoU_sub_bind PF08032.12 KII68041.1 - 0.12 12.6 0.1 0.21 11.9 0.1 1.3 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding HARP PF07443.13 KII68044.1 - 0.073 12.7 0.0 0.21 11.2 0.0 1.8 1 0 0 1 1 1 0 HepA-related protein (HARP) YhfH PF14149.6 KII68045.1 - 0.099 12.6 0.2 0.18 11.8 0.2 1.4 1 0 0 1 1 1 0 YhfH-like protein RT_RNaseH_2 PF17919.1 KII68048.1 - 9.2e-37 125.1 0.1 2.3e-36 123.8 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII68048.1 - 3e-35 120.6 0.0 7.6e-35 119.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII68048.1 - 8.8e-24 84.3 0.2 1.8e-23 83.2 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII68048.1 - 3.1e-20 72.5 0.0 8e-20 71.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII68048.1 - 8.2e-19 67.5 0.1 2.3e-18 66.0 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII68048.1 - 1.4e-07 31.9 0.0 4e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII68048.1 - 2.7e-07 31.1 0.0 7.4e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease rve_3 PF13683.6 KII68048.1 - 0.0014 18.4 0.4 0.0072 16.1 0.1 2.4 2 1 0 2 2 2 1 Integrase core domain zf-CCHC PF00098.23 KII68048.1 - 0.0044 17.0 2.5 0.0044 17.0 2.5 2.7 2 0 0 2 2 2 1 Zinc knuckle RVP PF00077.20 KII68048.1 - 0.0073 16.6 0.2 0.023 15.0 0.1 1.9 2 0 0 2 2 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII68048.1 - 0.089 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Ribosomal_L37e PF01907.19 KII68048.1 - 0.19 11.9 3.2 0.53 10.5 3.2 1.7 1 0 0 1 1 1 0 Ribosomal protein L37e APG6_N PF17675.1 KII68049.1 - 0.0023 18.5 15.7 0.11 13.0 7.3 2.1 1 1 1 2 2 2 2 Apg6 coiled-coil region CSN5_C PF18323.1 KII68049.1 - 0.011 16.7 2.7 0.058 14.3 0.5 2.1 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain Spectrin PF00435.21 KII68049.1 - 0.019 15.4 1.4 0.019 15.4 1.4 2.5 2 1 0 2 2 2 0 Spectrin repeat Snapin_Pallidin PF14712.6 KII68049.1 - 0.032 14.7 2.3 0.032 14.7 2.3 2.6 1 1 1 2 2 2 0 Snapin/Pallidin DS PF01916.17 KII68049.1 - 0.036 13.3 0.8 0.046 13.0 0.8 1.2 1 0 0 1 1 1 0 Deoxyhypusine synthase DUF4140 PF13600.6 KII68049.1 - 0.081 13.4 2.5 1.2 9.7 0.4 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF724 PF05266.14 KII68049.1 - 0.12 12.2 10.7 0.15 11.9 2.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) WXG100 PF06013.12 KII68049.1 - 0.12 12.6 1.9 11 6.3 0.5 2.9 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Nsp1_C PF05064.13 KII68049.1 - 0.12 12.1 13.3 0.016 15.0 6.4 2.1 1 1 0 2 2 2 0 Nsp1-like C-terminal region Fib_alpha PF08702.10 KII68049.1 - 0.17 12.1 14.5 0.16 12.2 6.9 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family XhlA PF10779.9 KII68049.1 - 0.18 12.0 14.4 0.093 12.9 1.6 3.2 1 1 2 3 3 3 0 Haemolysin XhlA Spc24 PF08286.11 KII68049.1 - 0.26 11.6 15.4 0.42 10.9 3.7 2.5 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 SlyX PF04102.12 KII68049.1 - 0.28 11.8 4.8 1.1 10.0 1.6 2.8 2 1 0 2 2 2 0 SlyX FlaC_arch PF05377.11 KII68049.1 - 0.29 11.6 6.2 7.1 7.1 0.4 2.9 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.8 KII68049.1 - 0.56 10.3 9.1 0.88 9.6 1.4 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF4164 PF13747.6 KII68049.1 - 0.56 10.5 7.3 6.1 7.2 2.7 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4164) Lebercilin PF15619.6 KII68049.1 - 0.94 9.1 14.9 1.4 8.6 7.7 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF16 PF01519.16 KII68049.1 - 0.94 10.0 11.3 2.5 8.7 0.9 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 Uso1_p115_C PF04871.13 KII68049.1 - 2 8.8 8.4 9.6 6.6 8.4 1.9 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region ABC_tran_CTD PF16326.5 KII68049.1 - 2.1 8.7 12.0 1.3 9.3 2.1 2.9 2 2 0 2 2 2 0 ABC transporter C-terminal domain Tropomyosin_1 PF12718.7 KII68049.1 - 4.7 7.4 15.5 3 8.0 3.3 2.3 1 1 0 2 2 2 0 Tropomyosin like DivIC PF04977.15 KII68049.1 - 7.2 6.5 10.9 3.4 7.5 2.6 2.5 2 0 0 2 2 2 0 Septum formation initiator DUF4450 PF14614.6 KII68050.1 - 0.16 11.5 0.7 0.17 11.4 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4450) APG6_N PF17675.1 KII68052.1 - 0.0012 19.3 3.2 0.013 16.0 0.2 2.1 2 0 0 2 2 2 1 Apg6 coiled-coil region STAT_alpha PF01017.20 KII68052.1 - 0.015 15.2 3.9 0.022 14.7 3.9 1.2 1 0 0 1 1 1 0 STAT protein, all-alpha domain NAPRTase_C PF17956.1 KII68052.1 - 0.074 13.5 0.3 1.2 9.6 0.1 1.9 1 1 1 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain Carbpep_Y_N PF05388.11 KII68052.1 - 0.079 13.5 4.0 0.14 12.7 0.2 2.0 1 1 0 2 2 2 0 Carboxypeptidase Y pro-peptide Prefoldin_2 PF01920.20 KII68052.1 - 0.31 11.0 6.1 0.16 12.0 1.8 2.1 2 0 0 2 2 2 0 Prefoldin subunit CLZ PF16526.5 KII68052.1 - 0.32 11.4 5.3 0.38 11.1 0.4 2.1 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels XhlA PF10779.9 KII68052.1 - 0.33 11.2 6.8 0.85 9.9 0.7 2.2 2 0 0 2 2 2 0 Haemolysin XhlA CAP PF00188.26 KII68054.1 - 5.3e-06 27.3 0.0 7.5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family FAS_meander PF17951.1 KII68054.1 - 0.075 12.8 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Fatty acid synthase meander beta sheet domain CAP PF00188.26 KII68055.1 - 4.9e-23 82.3 1.7 8.1e-16 59.0 0.9 2.2 2 0 0 2 2 2 2 Cysteine-rich secretory protein family zf-CCHC PF00098.23 KII68056.1 - 2.5e-06 27.3 6.6 0.00031 20.7 0.4 2.3 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII68056.1 - 1.7e-05 25.0 0.0 2.9e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 KII68056.1 - 0.0025 17.5 12.4 0.083 12.6 1.1 3.4 3 1 1 4 4 4 2 Zinc knuckle Asp_protease_2 PF13650.6 KII68056.1 - 0.027 15.1 0.0 0.045 14.4 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease zf-CHY PF05495.12 KII68056.1 - 0.072 13.6 4.6 0.11 13.0 4.6 1.2 1 0 0 1 1 1 0 CHY zinc finger Copper-fist PF00649.18 KII68056.1 - 0.53 9.8 9.5 0.065 12.7 3.2 2.3 1 1 1 2 2 2 0 Copper fist DNA binding domain zf-CCHC_2 PF13696.6 KII68056.1 - 1.1 9.2 8.1 8.5 6.3 2.0 2.6 2 0 0 2 2 2 0 Zinc knuckle LPD24 PF18839.1 KII68058.1 - 0.15 12.4 0.0 1.6 9.1 0.0 2.1 2 0 0 2 2 2 0 Large polyvalent protein associated domain 24 Acetyltransf_9 PF13527.7 KII68059.1 - 0.14 12.2 0.0 0.22 11.6 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain EGF_2 PF07974.13 KII68060.1 - 0.015 15.7 11.4 0.015 15.7 11.4 3.0 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 KII68060.1 - 3.4 8.5 15.7 3.1 8.6 5.2 3.6 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 KII68060.1 - 6.8 7.1 24.8 4.6 7.6 8.0 3.6 3 0 0 3 3 3 0 EGF-like domain HMG_box_5 PF14887.6 KII68061.1 - 0.1 12.6 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box 5 TMEM154 PF15102.6 KII68064.1 - 0.0012 18.7 0.1 0.0025 17.7 0.1 1.5 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 KII68064.1 - 0.018 15.3 0.0 0.038 14.3 0.0 1.5 1 0 0 1 1 1 0 Orf78 (ac78) DUF4793 PF16041.5 KII68064.1 - 0.02 15.0 0.1 3.2 7.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4793) DUF4711 PF15829.5 KII68064.1 - 0.03 14.3 0.3 0.056 13.4 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4711) Shisa PF13908.6 KII68064.1 - 0.049 13.9 0.0 0.08 13.2 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4366 PF14283.6 KII68064.1 - 0.059 13.4 0.1 0.15 12.1 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) BatA PF07584.11 KII68064.1 - 0.15 12.4 0.1 13 6.2 0.0 2.4 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal DUF3561 PF12084.8 KII68068.1 - 0.038 14.0 0.4 0.038 14.0 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) ARL2_Bind_BART PF11527.8 KII68069.1 - 0.027 14.6 0.6 0.032 14.3 0.6 1.2 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART DUF1186 PF06685.11 KII68070.1 - 0.038 13.4 0.6 0.043 13.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) zf-CCHC_2 PF13696.6 KII68072.1 - 0.2 11.5 1.6 0.42 10.5 1.6 1.5 1 0 0 1 1 1 0 Zinc knuckle Glyco_trans_4_5 PF16994.5 KII68073.1 - 0.056 13.0 1.0 0.088 12.4 0.2 1.7 2 0 0 2 2 2 0 Glycosyl-transferase family 4 Glyco_trans_4_5 PF16994.5 KII68074.1 - 0.056 13.0 1.0 0.088 12.4 0.2 1.7 2 0 0 2 2 2 0 Glycosyl-transferase family 4 DUF573 PF04504.14 KII68075.1 - 0.044 14.4 0.4 0.2 12.3 0.4 1.8 1 1 0 1 1 1 0 Protein of unknown function, DUF573 FLYWCH PF04500.16 KII68076.1 - 7.5e-05 22.8 2.7 0.00014 21.9 2.7 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain Borrelia_REV PF03978.13 KII68077.1 - 0.045 13.7 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein HTH_33 PF13592.6 KII68081.1 - 1.1e-06 28.2 0.0 2e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 KII68081.1 - 0.00012 21.8 0.1 0.27 11.1 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain PAX PF00292.18 KII68081.1 - 0.00038 20.4 0.1 0.00052 19.9 0.1 1.2 1 0 0 1 1 1 1 'Paired box' domain TrmB PF01978.19 KII68081.1 - 0.0006 19.7 0.0 0.0048 16.8 0.0 2.2 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 KII68081.1 - 0.0012 18.8 0.7 0.29 11.1 0.1 2.8 2 1 1 3 3 3 1 HTH domain HTH_32 PF13565.6 KII68081.1 - 0.0035 17.9 0.0 0.0052 17.4 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII68081.1 - 0.005 17.0 0.1 0.015 15.6 0.1 1.8 1 1 0 1 1 1 1 Transposase HTH_28 PF13518.6 KII68081.1 - 0.034 14.3 0.0 8.7 6.6 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_41 PF14502.6 KII68081.1 - 0.054 13.2 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_1_2 PF13022.6 KII68081.1 - 0.065 13.4 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_Tnp_IS630 PF01710.16 KII68081.1 - 0.18 11.8 0.7 2.1 8.4 0.7 2.1 1 1 0 1 1 1 0 Transposase HTH_Tnp_ISL3 PF13542.6 KII68081.1 - 0.25 10.8 2.4 2.2 7.8 0.3 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 CHB_HEX_C_1 PF13290.6 KII68082.1 - 0.063 13.3 0.4 0.11 12.6 0.4 1.5 1 1 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain Sec7 PF01369.20 KII68083.1 - 9.6e-45 152.5 1.8 2.2e-44 151.3 1.8 1.6 1 0 0 1 1 1 1 Sec7 domain IQ_SEC7_PH PF16453.5 KII68083.1 - 0.03 14.3 1.0 0.13 12.3 0.2 2.2 2 0 0 2 2 2 0 PH domain WW PF00397.26 KII68084.1 - 0.001 19.1 1.1 0.0019 18.2 1.1 1.5 1 0 0 1 1 1 1 WW domain RNA_pol_Rpb2_4 PF04566.13 KII68087.1 - 0.061 13.6 0.5 13 6.2 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 4 PRESAN PF09687.10 KII68087.1 - 0.18 12.4 4.4 0.19 12.3 0.6 2.1 1 1 1 2 2 2 0 Plasmodium RESA N-terminal PRESAN PF09687.10 KII68089.1 - 0.024 15.2 1.2 0.024 15.2 1.2 2.1 1 1 1 2 2 2 0 Plasmodium RESA N-terminal HTH_45 PF14947.6 KII68090.1 - 0.098 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DUF2811 PF10929.8 KII68096.1 - 0.034 14.4 0.0 0.053 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) RVT_1 PF00078.27 KII68097.1 - 1.3e-31 109.8 0.0 9.3e-31 107.1 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII68097.1 - 1.9e-05 25.1 0.0 4.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII68097.1 - 0.00013 22.2 0.0 0.00033 20.9 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII68097.1 - 0.0055 17.3 0.0 0.014 16.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A3 PF02160.15 KII68097.1 - 0.0076 15.8 3.4 0.2 11.1 1.4 2.4 2 0 0 2 2 2 1 Cauliflower mosaic virus peptidase (A3) Peptidase_A2B PF12384.8 KII68097.1 - 0.01 15.4 0.0 0.025 14.1 0.0 1.6 1 0 0 1 1 1 0 Ty3 transposon peptidase Peptidase_A2E PF12382.8 KII68097.1 - 0.011 15.8 0.1 0.041 13.9 0.1 2.0 1 0 0 1 1 1 0 Retrotransposon peptidase Asp_protease PF09668.10 KII68097.1 - 0.047 13.5 0.2 0.26 11.1 0.2 2.1 1 1 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 KII68097.1 - 0.55 10.4 4.9 0.19 11.9 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII68097.1 - 1.1 9.0 5.0 13 5.7 1.2 2.5 2 0 0 2 2 2 0 Zinc knuckle PaO PF08417.12 KII68099.1 - 0.001 19.1 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 Pheophorbide a oxygenase MLANA PF14991.6 KII68099.1 - 0.05 13.9 0.1 0.059 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein melan-A DUF4834 PF16118.5 KII68099.1 - 0.13 13.2 0.0 0.17 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Tmemb_9 PF05434.11 KII68099.1 - 0.16 11.9 2.4 0.21 11.5 2.4 1.3 1 1 0 1 1 1 0 TMEM9 Syndecan PF01034.20 KII68099.1 - 5.9 6.9 7.2 9.7 6.2 7.2 1.3 1 0 0 1 1 1 0 Syndecan domain DUF3899 PF13038.6 KII68100.1 - 0.013 16.0 0.1 0.045 14.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Phosphorylase PF00343.20 KII68102.1 - 6.5e-225 748.6 0.0 8.5e-225 748.2 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Phosphorylase PF00343.20 KII68103.1 - 1.3e-93 314.6 2.5 1.5e-93 314.4 2.5 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase BCS1_N PF08740.11 KII68104.1 - 1e-33 116.9 0.1 1.8e-33 116.1 0.1 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 KII68104.1 - 5.7e-16 59.1 0.0 9.4e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII68104.1 - 0.00019 21.9 0.0 0.00039 20.8 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KII68104.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KII68104.1 - 0.012 15.5 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 KII68104.1 - 0.014 15.4 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 KII68104.1 - 0.015 15.2 0.1 0.058 13.3 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 KII68104.1 - 0.017 15.7 0.0 0.04 14.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KII68104.1 - 0.018 15.4 0.1 0.055 13.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase ATPase PF06745.13 KII68104.1 - 0.018 14.4 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.6 KII68104.1 - 0.03 14.8 0.3 0.1 13.1 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KII68104.1 - 0.053 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KII68104.1 - 0.054 14.0 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 KII68104.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 KII68104.1 - 0.065 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KII68104.1 - 0.068 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KII68104.1 - 0.087 13.1 0.0 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 KII68104.1 - 0.17 11.6 0.0 0.67 9.7 0.0 2.0 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TIP49 PF06068.13 KII68104.1 - 0.2 10.8 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain PDZ_6 PF17820.1 KII68105.1 - 2.7e-06 27.1 0.0 5.8e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII68105.1 - 0.00022 21.5 0.2 0.00066 19.9 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KII68105.1 - 0.00073 19.8 0.5 0.0014 18.9 0.0 1.7 2 0 0 2 2 2 1 PDZ domain FAA_hydrolase_N PF09298.11 KII68105.1 - 0.039 14.1 0.0 0.083 13.1 0.0 1.5 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal Arfaptin PF06456.13 KII68106.1 - 0.051 13.2 0.3 0.051 13.2 0.3 1.8 2 0 0 2 2 2 0 Arfaptin-like domain Choline_transpo PF04515.12 KII68107.1 - 4.6e-05 22.8 13.4 5.3e-05 22.6 13.4 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter DUF4533 PF15047.6 KII68107.1 - 0.026 14.1 2.0 0.036 13.6 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) FixQ PF05545.11 KII68108.1 - 0.084 12.9 0.7 0.19 11.7 0.7 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Baculo_11_kDa PF06143.11 KII68108.1 - 1.7 8.3 6.3 15 5.3 2.9 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family DDE_1 PF03184.19 KII68109.1 - 1.3e-27 96.6 0.6 1.2e-20 73.9 0.2 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF1015 PF06245.11 KII68109.1 - 0.0054 15.6 0.0 0.009 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1015) ABC2_membrane PF01061.24 KII68110.1 - 4.1e-22 78.7 22.7 4.1e-22 78.7 22.7 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 KII68110.1 - 0.00038 19.7 24.7 0.00046 19.4 24.6 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 KII68110.1 - 0.34 10.1 10.7 0.37 10.0 10.7 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4897 PF16238.5 KII68112.1 - 0.017 14.9 0.4 0.037 13.9 0.3 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4897) CdiI_N PF18228.1 KII68112.1 - 0.1 12.5 0.3 0.21 11.5 0.1 1.7 1 1 0 1 1 1 0 CdiI N-terminal domain DUF1582 PF07621.11 KII68113.1 - 0.075 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1582) Thioredoxin_12 PF18400.1 KII68114.1 - 1.7e-06 28.0 0.3 1.7e-06 28.0 0.3 1.4 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 KII68115.1 - 1.7e-07 31.3 0.0 2.8e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_14 PF18402.1 KII68116.1 - 1.4e-31 110.4 7.6 2.1e-30 106.6 4.5 2.2 2 0 0 2 2 2 2 Thioredoxin-like domain UDP-g_GGTase PF06427.11 KII68116.1 - 3.2e-24 85.1 0.0 6.8e-24 84.1 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_24 PF18404.1 KII68117.1 - 4.6e-141 468.9 5.9 5.3e-141 468.7 5.9 1.0 1 0 0 1 1 1 1 Glucosyltransferase 24 Glyco_transf_8 PF01501.20 KII68117.1 - 3.2e-06 26.9 0.2 3.9e-06 26.6 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 PDZ_6 PF17820.1 KII68119.1 - 7.5e-08 32.1 0.1 1.2e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII68119.1 - 0.0004 20.6 0.0 0.00064 20.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KII68119.1 - 0.00066 20.0 0.0 0.0011 19.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KII68119.1 - 0.037 14.0 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Tricorn protease PDZ domain Metallophos PF00149.28 KII68121.1 - 1.5e-39 136.6 0.0 1.8e-39 136.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KII68121.1 - 0.00078 19.8 0.9 0.0014 19.0 0.9 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain CoA_binding PF02629.19 KII68122.1 - 6.2e-28 97.3 0.0 1.2e-27 96.4 0.0 1.5 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 KII68122.1 - 8.9e-15 54.8 0.0 1.4e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 CoA-ligase CoA_binding_2 PF13380.6 KII68122.1 - 0.00064 20.2 0.0 0.0021 18.6 0.0 1.9 1 0 0 1 1 1 1 CoA binding domain GFO_IDH_MocA PF01408.22 KII68122.1 - 0.0023 18.7 0.0 0.12 13.3 0.0 2.3 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Katanin_con80 PF13925.6 KII68128.1 - 0.00063 19.8 1.6 0.0008 19.5 1.0 1.5 1 1 1 2 2 2 1 con80 domain of Katanin OSCP PF00213.18 KII68128.1 - 0.037 14.1 0.8 0.056 13.6 0.7 1.4 1 1 0 1 1 1 0 ATP synthase delta (OSCP) subunit PBECR3 PF18812.1 KII68129.1 - 0.0029 17.6 0.7 0.0031 17.4 0.7 1.1 1 0 0 1 1 1 1 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 FolB PF02152.18 KII68129.1 - 0.046 14.3 0.0 0.055 14.0 0.0 1.2 1 0 0 1 1 1 0 Dihydroneopterin aldolase Vint PF14623.6 KII68130.1 - 0.12 12.2 0.2 0.23 11.3 0.2 1.4 1 0 0 1 1 1 0 Hint-domain GATase PF00117.28 KII68132.1 - 1.5e-32 112.9 0.0 3.3e-32 111.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 KII68132.1 - 4.5e-18 65.1 0.1 4.9e-09 36.1 0.0 3.2 2 1 0 2 2 2 2 GMP synthase C terminal domain Peptidase_C26 PF07722.13 KII68132.1 - 6.9e-09 35.8 0.0 2.2e-08 34.1 0.0 1.8 1 1 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 KII68132.1 - 6.3e-07 28.7 0.1 0.003 16.7 0.0 2.3 2 0 0 2 2 2 2 NAD synthase PAPS_reduct PF01507.19 KII68132.1 - 0.00048 20.2 0.0 0.0014 18.7 0.0 1.8 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family QueC PF06508.13 KII68132.1 - 0.0026 17.3 0.0 0.0093 15.5 0.0 1.8 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC DJ-1_PfpI PF01965.24 KII68132.1 - 0.007 16.2 0.1 0.11 12.3 0.1 2.6 3 0 0 3 3 3 1 DJ-1/PfpI family tRNA_Me_trans PF03054.16 KII68132.1 - 0.013 14.3 0.1 0.052 12.3 0.0 1.9 2 0 0 2 2 2 0 tRNA methyl transferase ATP_bind_3 PF01171.20 KII68132.1 - 0.035 13.9 0.1 0.65 9.7 0.0 2.7 3 0 0 3 3 3 0 PP-loop family Asn_synthase PF00733.21 KII68132.1 - 0.17 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase DUF773 PF05600.12 KII68133.1 - 9.4e-21 74.1 1.3 2e-18 66.4 1.3 2.0 1 1 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 GEP5 PF17053.5 KII68133.1 - 0.0023 17.8 1.4 0.0088 15.9 0.1 2.0 2 0 0 2 2 2 1 Genetic interactor of prohibitin 5 Tektin PF03148.14 KII68133.1 - 0.0032 16.3 0.2 0.0057 15.5 0.2 1.3 1 0 0 1 1 1 1 Tektin family OmpH PF03938.14 KII68133.1 - 0.0047 17.3 0.5 0.0047 17.3 0.5 1.6 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) DHR10 PF18595.1 KII68133.1 - 0.0054 16.8 0.2 0.0096 16.0 0.2 1.4 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain ATG16 PF08614.11 KII68133.1 - 0.01 16.1 0.6 0.015 15.5 0.6 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 KII68133.1 - 0.014 15.4 1.9 0.017 15.1 0.6 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Med9 PF07544.13 KII68133.1 - 0.016 15.3 0.7 0.041 14.0 0.7 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Spc7 PF08317.11 KII68133.1 - 0.016 14.1 1.5 0.03 13.2 1.5 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 KII68133.1 - 0.019 15.5 0.6 0.036 14.6 0.6 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region LemA PF04011.12 KII68133.1 - 0.028 14.3 2.8 0.071 13.0 1.1 2.0 1 1 1 2 2 2 0 LemA family TMF_TATA_bd PF12325.8 KII68133.1 - 0.029 14.6 0.2 0.052 13.8 0.2 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding MRG PF05712.13 KII68133.1 - 0.034 13.4 0.2 0.51 9.6 0.0 2.3 2 0 0 2 2 2 0 MRG BRE1 PF08647.11 KII68133.1 - 0.039 14.0 3.0 0.043 13.9 1.3 1.9 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase RasGAP_C PF03836.15 KII68133.1 - 0.045 13.9 1.0 0.69 10.1 0.1 2.1 2 0 0 2 2 2 0 RasGAP C-terminus DASH_Spc34 PF08657.10 KII68133.1 - 0.05 13.4 0.8 0.15 11.8 0.6 1.8 1 1 1 2 2 2 0 DASH complex subunit Spc34 Med21 PF11221.8 KII68133.1 - 0.05 13.8 0.5 0.089 13.0 0.3 1.6 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Spore_YunB PF09560.10 KII68133.1 - 0.063 13.3 0.1 0.37 10.8 0.0 2.0 2 0 0 2 2 2 0 Sporulation protein YunB (Spo_YunB) MitMem_reg PF13012.6 KII68133.1 - 0.065 13.7 0.5 0.68 10.4 0.4 2.3 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function TRAF_BIRC3_bd PF16673.5 KII68133.1 - 0.1 12.4 0.1 0.28 11.0 0.1 1.7 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain DUF3450 PF11932.8 KII68133.1 - 0.11 11.7 1.5 2.4 7.4 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 KII68133.1 - 0.36 11.0 2.6 1.6 8.9 2.4 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.20 KII68133.1 - 0.65 10.0 5.6 0.33 10.9 1.8 2.2 3 0 0 3 3 3 0 Prefoldin subunit DUF4709 PF15821.5 KII68134.1 - 0.046 14.0 0.3 0.068 13.5 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4709) Brix PF04427.18 KII68136.1 - 2.4e-19 70.2 0.4 2.8e-19 70.0 0.4 1.1 1 0 0 1 1 1 1 Brix domain CH PF00307.31 KII68137.1 - 8.3e-34 116.0 0.4 8.9e-20 70.9 0.2 2.7 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KII68137.1 - 1.8e-06 27.7 0.0 0.098 12.5 0.0 3.5 2 0 0 2 2 2 2 CAMSAP CH domain Filamin PF00630.19 KII68137.1 - 0.0043 17.8 5.1 0.13 13.1 0.3 3.3 2 1 0 2 2 2 1 Filamin/ABP280 repeat CH_2 PF06294.11 KII68137.1 - 0.094 12.8 0.1 0.99 9.6 0.1 2.5 2 0 0 2 2 2 0 CH-like domain in sperm protein Filamin PF00630.19 KII68138.1 - 9.7e-18 64.9 3.1 6.6e-11 42.9 0.0 3.5 2 1 1 3 3 3 3 Filamin/ABP280 repeat Y_Y_Y PF07495.13 KII68138.1 - 0.0037 17.2 1.1 1.1 9.3 0.7 2.9 2 1 0 2 2 2 2 Y_Y_Y domain TRP_N PF14558.6 KII68139.1 - 0.095 13.1 0.2 3.2 8.1 0.0 2.0 2 0 0 2 2 2 0 ML-like domain zf_CCCH_4 PF18345.1 KII68140.1 - 5.5e-12 45.3 27.1 3.8e-06 26.7 3.6 3.6 3 0 0 3 3 3 3 Zinc finger domain zf-CCCH_4 PF18044.1 KII68140.1 - 4.7e-08 32.6 24.9 1.9e-05 24.3 1.7 3.7 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 KII68140.1 - 1.4e-07 32.2 17.3 0.00075 20.2 1.8 3.8 3 2 1 4 4 4 3 Torus domain zf-CCCH_3 PF15663.5 KII68140.1 - 2.1e-07 31.1 2.3 2.1e-07 31.1 2.3 2.3 2 1 0 2 2 2 1 Zinc-finger containing family zf-CCCH PF00642.24 KII68140.1 - 5.9e-07 29.3 21.7 7.1e-05 22.6 1.4 3.5 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KII68140.1 - 0.00023 21.5 13.1 0.002 18.5 2.4 4.0 4 0 0 4 4 4 2 RNA-binding, Nab2-type zinc finger DUF1398 PF07166.11 KII68140.1 - 0.0062 16.6 0.1 0.016 15.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1398) KilA-N PF04383.13 KII68142.1 - 0.057 13.3 0.0 0.088 12.7 0.0 1.3 1 0 0 1 1 1 0 KilA-N domain V-set_CD47 PF08204.11 KII68145.1 - 0.17 11.9 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain HTH_23 PF13384.6 KII68146.1 - 1.2e-05 24.9 0.0 2.4e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 KII68146.1 - 3.7e-05 23.7 0.0 6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 KII68146.1 - 0.012 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_38 PF13936.6 KII68146.1 - 0.048 13.4 0.0 0.099 12.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HU-CCDC81_bac_2 PF18175.1 KII68146.1 - 0.065 13.1 0.1 3.6 7.5 0.0 2.3 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 HTH_7 PF02796.15 KII68146.1 - 0.086 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase MR_MLE_C PF13378.6 KII68147.1 - 2e-29 102.7 0.0 2.4e-29 102.5 0.0 1.0 1 0 0 1 1 1 1 Enolase C-terminal domain-like SAM_1 PF00536.30 KII68148.1 - 1e-08 35.5 0.4 0.00042 20.7 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KII68148.1 - 5.8e-07 29.5 1.2 0.003 17.6 0.1 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) DUF2025 PF09634.10 KII68148.1 - 0.05 13.6 0.7 4.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2025) FA_FANCE PF11510.8 KII68148.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Fanconi Anaemia group E protein FANCE DNA_pol3_a_NI PF14480.6 KII68149.1 - 0.027 14.4 0.8 0.05 13.6 0.7 1.6 1 1 0 1 1 1 0 DNA polymerase III polC-type N-terminus I MTBP_C PF14920.6 KII68152.1 - 2.9e-15 56.7 0.6 3.8e-15 56.3 0.6 1.2 1 0 0 1 1 1 1 MDM2-binding Inos-1-P_synth PF01658.17 KII68152.1 - 0.0053 17.0 1.0 0.008 16.4 1.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase LAG1-DNAbind PF09271.11 KII68152.1 - 0.05 14.2 0.3 0.078 13.6 0.3 1.4 1 0 0 1 1 1 0 LAG1, DNA binding SAMP PF05924.11 KII68152.1 - 0.095 12.0 0.2 0.18 11.1 0.2 1.4 1 0 0 1 1 1 0 SAMP Motif RRS1 PF04939.12 KII68154.1 - 6.6e-34 117.1 4.3 9.8e-34 116.6 4.3 1.2 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DNA_pol_alpha_N PF12254.8 KII68154.1 - 0.84 9.8 3.7 0.42 10.7 0.8 2.0 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal BRCT PF00533.26 KII68155.1 - 0.08 13.3 0.8 0.22 11.9 0.0 2.1 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain SIT PF15330.6 KII68156.1 - 0.055 13.9 0.1 0.072 13.5 0.1 1.2 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Rep_3 PF01051.21 KII68157.1 - 9.1e-20 71.4 0.2 1.2e-19 71.1 0.2 1.1 1 0 0 1 1 1 1 Initiator Replication protein TFIIE_beta PF02186.15 KII68157.1 - 0.014 15.7 0.0 0.039 14.2 0.0 1.7 1 0 0 1 1 1 0 TFIIE beta subunit core domain UvrA_inter PF17760.1 KII68157.1 - 0.062 13.4 0.0 3.3 7.8 0.0 2.9 3 0 0 3 3 3 0 UvrA interaction domain HTH_36 PF13730.6 KII68157.1 - 0.14 12.2 0.0 0.43 10.6 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_54 PF18607.1 KII68159.1 - 7e-30 103.0 0.1 1.1e-29 102.3 0.1 1.3 1 0 0 1 1 1 1 ParA helix turn helix domain AAA_31 PF13614.6 KII68159.1 - 1.7e-13 50.8 0.1 2.7e-13 50.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 KII68159.1 - 5.9e-08 32.8 0.0 1.1e-07 32.0 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 KII68159.1 - 0.0009 18.8 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 KII68159.1 - 0.017 14.6 0.0 0.026 14.0 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase Trans_reg_C PF00486.28 KII68161.1 - 3.5e-11 43.0 0.0 1.7e-10 40.8 0.0 1.9 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal MatB PF16449.5 KII68162.1 - 5.8e-59 198.6 17.6 8.8e-59 198.0 17.6 1.3 1 0 0 1 1 1 1 Fimbrillin MatB EcpB_C PF18649.1 KII68163.1 - 5.2e-33 112.8 0.5 1.1e-32 111.8 0.5 1.6 1 0 0 1 1 1 1 EcpB C-terminal domain PapD_N PF00345.20 KII68163.1 - 0.0055 16.6 0.0 0.0075 16.2 0.0 1.2 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain TcfC PF16967.5 KII68164.1 - 8.5e-24 82.8 0.0 1.6e-23 81.9 0.0 1.5 1 0 0 1 1 1 1 E-set like domain CooC_C PF15976.5 KII68164.1 - 1.3e-19 70.0 0.1 5.2e-19 68.1 0.0 2.2 2 0 0 2 2 2 1 CS1-pili formation C-terminal Mnd1 PF03962.15 KII68166.1 - 1.8e-28 98.6 0.4 1.8e-28 98.6 0.4 2.0 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 KII68166.1 - 6.1e-20 71.1 0.7 2.9e-19 68.9 0.7 2.2 1 0 0 1 1 1 1 Leucine zipper with capping helix domain DivIVA PF05103.13 KII68166.1 - 0.0034 17.4 0.9 0.0034 17.4 0.9 2.0 2 0 0 2 2 2 1 DivIVA protein FapA PF03961.13 KII68166.1 - 0.0045 15.6 2.7 0.0061 15.2 2.7 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A Fmp27_WPPW PF10359.9 KII68166.1 - 0.0046 15.9 3.1 0.0059 15.5 3.1 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain HalX PF08663.10 KII68166.1 - 0.013 15.8 0.5 0.031 14.6 0.5 1.7 1 0 0 1 1 1 0 HalX domain Penicillinase_R PF03965.16 KII68166.1 - 0.029 14.7 1.1 0.045 14.1 0.5 1.7 2 0 0 2 2 2 0 Penicillinase repressor T3SchapCesA PF11439.8 KII68166.1 - 0.089 12.9 2.8 0.12 12.6 1.6 1.8 2 0 0 2 2 2 0 Type III secretion system filament chaperone CesA HIP1_clath_bdg PF16515.5 KII68166.1 - 0.18 12.4 6.8 2.4 8.8 6.6 2.4 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Bap31_Bap29_C PF18035.1 KII68166.1 - 3 7.9 11.0 28 4.8 11.0 2.4 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF5320 PF17253.2 KII68166.1 - 4.1 8.5 4.1 40 5.4 0.1 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5320) Integrase_H2C2 PF17921.1 KII68168.1 - 4.9e-14 52.2 0.0 1.8e-13 50.4 0.0 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII68168.1 - 7.1e-14 52.0 0.0 1.4e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain SET_assoc PF11767.8 KII68168.1 - 0.065 12.9 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RT_RNaseH PF17917.1 KII68171.1 - 5.6e-05 23.4 0.0 0.00011 22.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII68171.1 - 8.5e-05 22.5 0.1 0.00032 20.7 0.1 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII68171.1 - 0.034 14.3 0.2 9.4 6.5 0.0 2.4 2 0 0 2 2 2 0 Integrase core domain Tetraspanin PF00335.20 KII68173.1 - 4.3e-12 46.2 11.9 5.8e-12 45.8 11.9 1.2 1 0 0 1 1 1 1 Tetraspanin family ABC2_membrane_3 PF12698.7 KII68173.1 - 2.6 7.1 22.8 3.6 6.6 0.9 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein Asp_protease PF09668.10 KII68175.1 - 0.04 13.7 0.1 0.069 12.9 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease Med7 PF05983.11 KII68176.1 - 0.0075 16.4 0.0 0.0091 16.1 0.0 1.1 1 0 0 1 1 1 1 MED7 protein HTH_22 PF13309.6 KII68178.1 - 1.5 8.9 3.9 15 5.8 0.2 2.8 3 0 0 3 3 3 0 HTH domain Hexokinase_2 PF03727.16 KII68179.1 - 1.8e-50 171.6 0.2 2e-50 171.4 0.2 1.0 1 0 0 1 1 1 1 Hexokinase DUF4474 PF14751.6 KII68181.1 - 0.048 13.1 0.4 0.1 12.0 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4474) Arm PF00514.23 KII68182.1 - 6e-17 61.1 1.3 6.9e-07 29.1 0.2 6.2 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KII68182.1 - 9.9e-08 32.3 0.0 0.0074 16.8 0.0 4.1 4 1 0 4 4 4 2 HEAT-like repeat Arm_3 PF16186.5 KII68182.1 - 5.1e-06 25.9 0.5 1.7e-05 24.3 0.5 1.9 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 KII68182.1 - 0.0001 22.6 0.0 0.095 13.1 0.0 3.8 2 2 1 4 4 4 2 HEAT repeats HEAT PF02985.22 KII68182.1 - 0.00013 21.9 0.4 15 6.2 0.2 4.8 4 0 0 4 4 4 1 HEAT repeat HEAT_PBS PF03130.16 KII68182.1 - 0.16 12.7 0.0 0.62 10.9 0.0 2.1 1 0 0 1 1 1 0 PBS lyase HEAT-like repeat Arm PF00514.23 KII68183.1 - 5.6e-08 32.6 0.4 0.0011 18.9 0.0 4.0 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat HET PF06985.11 KII68184.1 - 0.08 13.3 2.7 0.15 12.4 2.7 1.7 1 1 0 1 1 1 0 Heterokaryon incompatibility protein (HET) DDE_3 PF13358.6 KII68187.1 - 5.3e-09 36.0 0.0 6.6e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Arm PF00514.23 KII68190.1 - 6.3e-06 26.1 0.7 0.53 10.4 0.0 3.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 KII68190.1 - 0.079 13.1 0.5 0.22 11.7 0.2 1.7 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Katanin_con80 PF13925.6 KII68190.1 - 0.18 11.8 0.7 0.28 11.2 0.7 1.5 1 0 0 1 1 1 0 con80 domain of Katanin DUF1771 PF08590.10 KII68191.1 - 0.18 12.2 1.8 0.18 12.2 0.3 1.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1771) Arm PF00514.23 KII68192.1 - 7.5e-08 32.2 0.1 0.028 14.5 0.0 3.8 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KII68192.1 - 1e-05 25.0 0.5 2.8e-05 23.6 0.5 1.7 1 0 0 1 1 1 1 Atypical Arm repeat RTP1_C1 PF10363.9 KII68192.1 - 0.078 13.2 0.4 0.33 11.1 0.2 2.1 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Herpes_BBRF1 PF04793.12 KII68195.1 - 0.022 13.8 0.0 0.024 13.7 0.0 1.1 1 0 0 1 1 1 0 BRRF1-like protein Kazal_3 PF18434.1 KII68197.1 - 0.09 12.5 0.2 0.19 11.5 0.2 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain SNAP PF14938.6 KII68198.1 - 5.8e-72 242.5 14.3 6.9e-72 242.2 14.3 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 KII68198.1 - 5.4e-06 26.1 3.5 1.3 9.2 0.1 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KII68198.1 - 9.6e-05 22.6 2.7 0.07 13.4 0.1 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 KII68198.1 - 0.00083 19.8 4.6 11 7.0 0.2 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Sel1 PF08238.12 KII68198.1 - 0.0094 16.6 0.4 2.1 9.2 0.0 3.5 3 0 0 3 3 3 1 Sel1 repeat zf-BED PF02892.15 KII68198.1 - 0.073 13.1 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 BED zinc finger TPR_2 PF07719.17 KII68198.1 - 0.24 11.6 16.9 5.8 7.3 0.3 5.5 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII68198.1 - 1.3 9.4 13.8 1.9 8.9 0.2 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KII68198.1 - 8.6 6.9 7.9 21 5.7 0.3 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_28 PF02636.17 KII68199.1 - 6.1e-09 35.9 0.0 6.8e-09 35.7 0.0 1.0 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF3346 PF11826.8 KII68199.1 - 0.059 13.2 0.0 0.07 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3346) Methyltransf_28 PF02636.17 KII68200.1 - 1.6e-20 73.9 0.0 2e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase GDE_N PF12439.8 KII68200.1 - 0.19 11.1 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme N terminal TPR_MLP1_2 PF07926.12 KII68201.1 - 0.0085 16.2 7.2 0.0085 16.2 7.2 3.3 1 1 2 3 3 3 1 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 KII68201.1 - 0.059 12.7 28.8 0.026 13.8 9.1 4.0 1 1 4 5 5 5 0 Protein of unknown function (DUF3450) Myosin_tail_1 PF01576.19 KII68201.1 - 0.73 7.6 32.7 0.39 8.5 13.9 2.0 1 1 1 2 2 2 0 Myosin tail DUF1664 PF07889.12 KII68201.1 - 4 7.5 22.1 0.18 11.8 2.4 4.2 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) TEX13 PF15186.6 KII68201.1 - 6.8 6.4 15.9 0.03 14.0 1.7 3.3 2 1 0 3 3 3 0 Testis-expressed sequence 13 protein family DUF4407 PF14362.6 KII68201.1 - 8.4 5.6 14.9 2.3e+02 0.9 14.9 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) RT_RNaseH PF17917.1 KII68202.1 - 2.5e-38 130.6 0.5 5.4e-37 126.3 0.0 3.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII68202.1 - 9.7e-38 128.2 0.6 1.3e-36 124.6 0.1 2.8 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII68202.1 - 5.7e-22 78.1 0.0 1.5e-21 76.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII68202.1 - 1.2e-19 70.1 0.3 2.9e-19 68.9 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII68202.1 - 1.7e-11 44.1 0.2 3.4e-11 43.1 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2 PF09337.10 KII68202.1 - 0.00012 22.2 0.0 0.00037 20.6 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII68202.1 - 0.00077 19.2 0.1 0.0031 17.2 0.1 2.1 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 KII68203.1 - 4.4e-09 36.2 0.0 3.1e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII68203.1 - 0.00022 21.1 6.2 0.096 12.8 0.4 2.6 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII68203.1 - 0.0012 19.1 0.0 0.0028 17.9 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KII68203.1 - 0.0018 18.1 0.1 0.0048 16.7 0.1 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease Spuma_A9PTase PF03539.14 KII68203.1 - 0.038 14.1 0.0 0.17 12.0 0.0 2.0 1 1 1 2 2 2 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.6 KII68203.1 - 0.21 12.2 0.0 0.57 10.8 0.0 1.8 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_3 PF13917.6 KII68203.1 - 0.44 10.5 7.5 1.3 9.1 0.5 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII68203.1 - 0.46 10.2 8.1 5.9 6.7 2.3 2.5 1 1 1 2 2 2 0 Zinc knuckle CK_II_beta PF01214.18 KII68204.1 - 6.6e-39 133.6 0.1 9.1e-39 133.1 0.1 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CxC5 PF18718.1 KII68204.1 - 0.082 13.0 0.3 0.17 11.9 0.2 1.6 1 1 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases DUF5537 PF17690.1 KII68204.1 - 0.13 12.0 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5537) ABC_tran PF00005.27 KII68206.1 - 2.3e-51 173.9 0.1 1.1e-28 100.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KII68206.1 - 7.1e-49 166.9 54.2 1.4e-24 87.2 21.9 2.5 3 0 0 3 3 2 2 ABC transporter transmembrane region SMC_N PF02463.19 KII68206.1 - 1.8e-11 43.9 6.9 0.011 15.2 0.1 4.4 3 1 1 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KII68206.1 - 2.7e-06 27.9 0.0 0.093 13.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 KII68206.1 - 3.4e-05 23.8 5.1 0.18 11.6 0.2 4.0 2 2 2 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 KII68206.1 - 6.2e-05 23.3 0.1 0.52 10.6 0.1 2.8 2 1 0 2 2 2 2 AAA domain NACHT PF05729.12 KII68206.1 - 8.2e-05 22.6 0.1 0.03 14.2 0.0 3.0 2 0 0 2 2 2 1 NACHT domain AAA_15 PF13175.6 KII68206.1 - 9.7e-05 22.2 2.4 0.0041 16.9 0.5 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 KII68206.1 - 0.00011 22.0 0.0 0.041 13.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KII68206.1 - 0.0002 21.4 0.7 0.22 11.6 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 KII68206.1 - 0.00021 21.0 0.7 0.69 9.7 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Pox_A32 PF04665.12 KII68206.1 - 0.00036 20.1 0.4 0.73 9.2 0.0 2.5 2 0 0 2 2 2 2 Poxvirus A32 protein AAA_23 PF13476.6 KII68206.1 - 0.00047 20.7 0.7 0.2 12.1 0.3 2.7 2 0 0 2 2 2 1 AAA domain Roc PF08477.13 KII68206.1 - 0.0012 19.0 0.1 0.8 9.9 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ABC_ATPase PF09818.9 KII68206.1 - 0.0075 15.1 0.6 0.046 12.5 0.1 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class NB-ARC PF00931.22 KII68206.1 - 0.009 15.2 0.0 3.3 6.8 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain DUF87 PF01935.17 KII68206.1 - 0.0099 16.0 2.0 0.3 11.1 0.1 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 KII68206.1 - 0.011 15.7 0.1 5.1 7.0 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 KII68206.1 - 0.014 14.9 0.1 6.1 6.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 KII68206.1 - 0.015 14.7 0.7 3.7 6.8 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Viral_helicase1 PF01443.18 KII68206.1 - 0.015 15.0 0.1 2.4 7.9 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 KII68206.1 - 0.02 14.5 0.9 1.6 8.3 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KII68206.1 - 0.021 14.5 0.0 11 5.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 KII68206.1 - 0.036 13.0 0.2 6.6 5.5 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.23 KII68206.1 - 0.039 14.0 1.0 9.3 6.3 0.5 2.7 2 0 0 2 2 2 0 Dynamin family Zeta_toxin PF06414.12 KII68206.1 - 0.042 13.1 0.1 9.1 5.5 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin FKBP_N_2 PF18023.1 KII68206.1 - 0.045 13.8 0.3 0.12 12.5 0.3 1.6 1 0 0 1 1 1 0 BDBT FKBP like N-terminal T2SSE PF00437.20 KII68206.1 - 0.052 12.6 0.0 2.6 7.0 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Septin PF00735.18 KII68206.1 - 0.066 12.5 0.1 2.7 7.2 0.0 2.3 2 0 0 2 2 2 0 Septin AAA_5 PF07728.14 KII68206.1 - 0.098 12.7 0.3 10 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MobB PF03205.14 KII68206.1 - 0.12 12.3 0.8 4.6 7.2 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.22 KII68206.1 - 0.13 12.6 0.5 32 5.0 0.0 3.3 3 0 0 3 3 3 0 RNA helicase AAA_13 PF13166.6 KII68206.1 - 0.17 10.5 2.2 4 5.9 0.3 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KII68206.1 - 0.2 11.8 0.0 2.9 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KII68207.1 - 3.3e-17 63.3 0.0 9.2e-17 61.8 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 KII68207.1 - 0.00013 21.5 0.1 0.00016 21.2 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain FKBP_N_2 PF18023.1 KII68207.1 - 0.022 14.9 0.2 0.033 14.3 0.2 1.4 1 0 0 1 1 1 0 BDBT FKBP like N-terminal ABC_membrane PF00664.23 KII68208.1 - 1.7e-24 86.9 21.1 1.7e-24 86.9 21.1 1.4 2 0 0 2 2 2 1 ABC transporter transmembrane region SH3_2 PF07653.17 KII68208.1 - 0.055 13.2 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 KII68208.1 - 0.17 11.5 0.4 0.42 10.3 0.1 1.8 2 0 0 2 2 2 0 SH3 domain ABC_tran PF00005.27 KII68210.1 - 3e-52 176.8 0.2 1.2e-29 103.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KII68210.1 - 5.8e-45 154.1 61.0 2.4e-24 86.5 26.9 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 KII68210.1 - 3.4e-10 39.7 6.8 0.021 14.3 0.2 4.3 3 1 1 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KII68210.1 - 2.1e-06 27.7 2.8 0.046 13.5 0.2 4.1 2 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KII68210.1 - 4.3e-06 26.7 2.8 0.00061 19.6 0.0 3.4 3 1 0 3 3 3 1 AAA ATPase domain AAA_16 PF13191.6 KII68210.1 - 5.5e-06 26.9 0.0 0.16 12.4 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 KII68210.1 - 1.9e-05 24.5 0.0 0.016 15.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KII68210.1 - 4.2e-05 23.9 0.1 0.35 11.2 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KII68210.1 - 0.00015 21.4 1.2 0.59 9.9 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.12 KII68210.1 - 0.00028 20.9 0.0 0.074 13.0 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_23 PF13476.6 KII68210.1 - 0.00039 21.0 0.7 0.16 12.5 0.3 2.5 2 0 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 KII68210.1 - 0.00047 19.7 0.6 0.71 9.3 0.0 2.5 2 0 0 2 2 2 2 Poxvirus A32 protein MMR_HSR1 PF01926.23 KII68210.1 - 0.00069 19.7 0.6 0.21 11.7 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 KII68210.1 - 0.00074 19.7 0.1 0.44 10.8 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 KII68210.1 - 0.0088 15.6 0.3 5.3 6.5 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 KII68210.1 - 0.0099 15.1 0.0 4 6.5 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain FtsK_SpoIIIE PF01580.18 KII68210.1 - 0.013 14.9 0.7 2.9 7.2 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 KII68210.1 - 0.013 15.4 0.4 4.8 7.1 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_30 PF13604.6 KII68210.1 - 0.015 15.0 0.0 6.9 6.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 KII68210.1 - 0.022 14.5 0.1 2.7 7.6 0.0 2.7 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 KII68210.1 - 0.027 14.1 1.1 1.5 8.4 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 KII68210.1 - 0.032 14.3 2.1 0.29 11.2 0.1 2.7 3 0 0 3 3 2 0 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 KII68210.1 - 0.033 13.1 0.2 5.8 5.7 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.12 KII68210.1 - 0.043 13.1 0.0 7.4 5.8 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin FKBP_N_2 PF18023.1 KII68210.1 - 0.053 13.6 0.5 0.12 12.5 0.5 1.5 1 0 0 1 1 1 0 BDBT FKBP like N-terminal Septin PF00735.18 KII68210.1 - 0.054 12.8 0.1 2.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Septin ABC_ATPase PF09818.9 KII68210.1 - 0.056 12.2 1.2 0.96 8.2 0.2 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class T2SSE PF00437.20 KII68210.1 - 0.063 12.3 0.0 2.7 7.0 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_5 PF07728.14 KII68210.1 - 0.064 13.2 0.2 8.3 6.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KII68210.1 - 0.11 12.9 0.2 27 5.2 0.0 3.2 3 0 0 3 3 2 0 RNA helicase SH3_1 PF00018.28 KII68210.1 - 0.11 12.1 0.1 0.38 10.4 0.0 1.9 2 0 0 2 2 2 0 SH3 domain SbcCD_C PF13558.6 KII68210.1 - 0.13 12.5 0.4 45 4.4 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DEAD PF00270.29 KII68210.1 - 0.15 11.8 0.1 14 5.4 0.0 3.1 3 0 0 3 3 3 0 DEAD/DEAH box helicase MobB PF03205.14 KII68210.1 - 0.18 11.7 0.6 8.9 6.2 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Dynamin_N PF00350.23 KII68210.1 - 0.2 11.7 0.7 9.1 6.3 0.5 2.5 2 0 0 2 2 2 0 Dynamin family AAA_25 PF13481.6 KII68210.1 - 0.22 11.1 0.0 12 5.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain ANAPC4_WD40 PF12894.7 KII68211.1 - 3.6e-06 27.2 0.0 0.18 12.1 0.0 3.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KII68211.1 - 1.9e-05 25.3 0.0 0.37 11.7 0.0 4.5 4 0 0 4 4 4 1 WD domain, G-beta repeat DIPSY PF11763.8 KII68211.1 - 0.036 14.2 0.4 0.11 12.7 0.3 1.9 1 1 0 1 1 1 0 Cell-wall adhesin ligand-binding C-terminal PIN_12 PF16289.5 KII68212.1 - 0.0055 17.2 0.1 0.0066 17.0 0.1 1.1 1 0 0 1 1 1 1 PIN domain DUF3891 PF13030.6 KII68213.1 - 9.2 6.0 10.9 28 4.4 0.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3891) Carb_bind PF10645.9 KII68214.1 - 0.065 13.5 0.3 0.14 12.4 0.3 1.6 1 1 0 1 1 1 0 Carbohydrate binding Integrin_beta PF00362.18 KII68215.1 - 9.4e-32 110.6 0.1 1.3e-25 90.5 0.0 2.3 1 1 1 2 2 2 2 Integrin beta chain VWA domain DDE_3 PF13358.6 KII68215.1 - 1.1e-08 34.9 0.1 2.5e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease PSI_integrin PF17205.3 KII68215.1 - 8.5e-07 28.6 8.9 1.6e-06 27.7 8.9 1.5 1 0 0 1 1 1 1 Integrin plexin domain PSI PF01437.25 KII68215.1 - 0.022 15.3 4.8 0.047 14.2 4.8 1.5 1 0 0 1 1 1 0 Plexin repeat NusG_II PF07009.11 KII68215.1 - 2.2 8.5 5.0 18 5.6 0.3 2.9 3 0 0 3 3 3 0 NusG domain II Integrin_B_tail PF07965.12 KII68216.1 - 0.021 15.3 2.9 0.031 14.7 2.9 1.3 1 0 0 1 1 1 0 Integrin beta tail domain DDE_3 PF13358.6 KII68217.1 - 1.1e-07 31.7 0.0 1.2e-07 31.5 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII68218.1 - 1.2e-29 103.0 0.0 1.3e-29 102.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII68218.1 - 0.0012 19.0 0.0 0.0018 18.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Telomere_reg-2 PF10193.9 KII68218.1 - 0.077 13.5 0.1 0.23 11.9 0.0 1.6 1 1 1 2 2 2 0 Telomere length regulation protein Abhydrolase_1 PF00561.20 KII68219.1 - 2.1e-21 76.7 0.0 1.2e-20 74.3 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KII68219.1 - 3.1e-14 52.8 0.0 1.2e-13 50.8 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KII68219.1 - 4.7e-14 53.5 0.0 6.3e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PAF-AH_p_II PF03403.13 KII68219.1 - 0.00043 18.9 0.0 0.0021 16.6 0.0 1.8 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Ndr PF03096.14 KII68219.1 - 0.00046 19.0 0.0 0.0015 17.3 0.0 1.8 2 0 0 2 2 2 1 Ndr family LIDHydrolase PF10230.9 KII68219.1 - 0.029 13.9 0.0 0.072 12.6 0.0 1.6 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 KII68219.1 - 0.035 13.9 0.0 0.064 13.1 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase DUF915 PF06028.11 KII68219.1 - 0.053 12.8 0.1 0.089 12.1 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.14 KII68219.1 - 0.054 13.0 0.0 0.33 10.4 0.0 2.2 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Esterase PF00756.20 KII68219.1 - 0.064 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative esterase APT PF03440.14 KII68219.1 - 0.19 11.7 0.0 0.47 10.4 0.0 1.6 1 0 0 1 1 1 0 Aerolysin/Pertussis toxin (APT) domain Transglut_core PF01841.19 KII68221.1 - 2.4e-07 31.2 0.0 3.2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_N PF00868.20 KII68222.1 - 3.8e-11 43.4 0.1 6.5e-11 42.6 0.1 1.4 1 0 0 1 1 1 1 Transglutaminase family RAP1 PF07218.11 KII68223.1 - 0.54 8.5 17.0 0.65 8.2 17.0 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AF-4 PF05110.13 KII68223.1 - 9.5 4.1 21.0 11 3.9 21.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein zf-CHCC PF10276.9 KII68224.1 - 4.7e-17 61.8 3.1 6.4e-17 61.3 3.1 1.2 1 0 0 1 1 1 1 Zinc-finger domain adh_short PF00106.25 KII68228.1 - 3.1e-18 65.9 0.0 4e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII68228.1 - 2.9e-14 53.2 0.0 3.6e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII68228.1 - 3.8e-07 30.2 0.0 4.3e-07 30.0 0.0 1.0 1 0 0 1 1 1 1 KR domain TusA PF01206.17 KII68228.1 - 0.017 15.0 0.0 0.26 11.2 0.0 2.3 2 1 1 3 3 3 0 Sulfurtransferase TusA Epimerase PF01370.21 KII68228.1 - 0.043 13.3 0.0 0.046 13.2 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 KII68228.1 - 0.077 12.9 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 KII68228.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AdoHcyase_NAD PF00670.21 KII68228.1 - 0.17 11.9 1.0 0.19 11.8 1.0 1.3 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain HTH_23 PF13384.6 KII68229.1 - 0.00015 21.4 0.5 0.61 10.0 0.0 2.3 2 0 0 2 2 2 2 Homeodomain-like domain HTH_33 PF13592.6 KII68229.1 - 0.0002 21.0 0.0 0.00031 20.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix CENP-B_N PF04218.13 KII68229.1 - 0.00023 20.7 0.2 0.038 13.6 0.0 2.7 3 0 0 3 3 3 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 KII68229.1 - 0.00061 19.9 0.2 0.0073 16.4 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII68229.1 - 0.00078 19.6 0.1 0.0019 18.4 0.0 1.7 2 0 0 2 2 2 1 Transposase HTH_Tnp_1 PF01527.20 KII68229.1 - 0.076 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Transposase Moricin PF06451.11 KII68229.1 - 0.086 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Moricin Pico_P2B PF01552.17 KII68229.1 - 0.23 11.6 0.9 0.34 11.1 0.1 1.6 2 0 0 2 2 2 0 Picornavirus 2B protein DDE_3 PF13358.6 KII68230.1 - 0.0028 17.4 0.1 0.0045 16.8 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Annexin PF00191.20 KII68235.1 - 1.1e-07 31.9 0.0 0.0053 16.8 0.0 3.5 3 1 1 4 4 4 3 Annexin DUF4488 PF14869.6 KII68235.1 - 0.16 11.9 0.0 0.34 10.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4488) DDE_Tnp_IS1595 PF12762.7 KII68236.1 - 1.1e-05 25.4 0.1 9.4e-05 22.5 0.1 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain NPM1-C PF16276.5 KII68236.1 - 0.22 11.5 0.1 0.44 10.6 0.1 1.5 1 0 0 1 1 1 0 Nucleophosmin C-terminal domain zf-H2C2_2 PF13465.6 KII68237.1 - 1.4e-21 75.8 43.7 1.4e-09 37.9 2.0 6.3 6 1 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KII68237.1 - 5.9e-19 67.1 41.5 0.00031 21.3 2.7 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.26 KII68237.1 - 2.8e-17 62.1 43.8 1.7e-06 28.2 4.1 5.7 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KII68237.1 - 7.4e-12 45.2 27.4 0.0042 17.3 1.0 5.4 5 0 0 5 5 5 5 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 KII68237.1 - 6e-07 29.2 20.6 0.014 15.3 0.9 5.1 5 0 0 5 5 5 3 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 KII68237.1 - 1.4e-06 28.0 1.1 1.4e-06 28.0 1.1 4.8 5 0 0 5 5 4 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 KII68237.1 - 3.4e-05 23.7 43.2 0.00029 20.7 2.8 5.7 6 0 0 6 6 5 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KII68237.1 - 0.00058 20.2 28.1 1.4 9.3 2.5 5.2 1 1 4 5 5 5 3 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 KII68237.1 - 0.011 15.8 19.6 0.9 9.7 0.1 4.8 3 2 1 4 4 4 0 Zinc ribbon domain Zn_ribbon_SprT PF17283.2 KII68237.1 - 0.085 12.8 16.0 0.14 12.1 5.3 4.1 4 0 0 4 4 4 0 SprT-like zinc ribbon domain zf_C2H2_ZHX PF18387.1 KII68237.1 - 0.14 11.8 0.3 0.14 11.8 0.3 4.1 2 1 3 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 KII68237.1 - 0.27 11.9 15.6 0.26 11.9 9.6 3.3 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 KII68237.1 - 0.34 11.4 29.9 0.4 11.1 0.6 5.2 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 KII68237.1 - 0.34 10.5 17.2 2.3 7.9 0.0 4.7 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 KII68237.1 - 0.4 11.5 17.9 0.18 12.5 2.3 3.1 1 1 3 4 4 4 0 zinc-ribbon family PyrI_C PF02748.15 KII68237.1 - 0.63 10.0 13.5 7.1 6.6 0.2 4.9 3 2 2 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 KII68237.1 - 1.4 9.0 29.3 0.65 10.1 4.1 4.7 1 1 3 4 4 4 0 BED zinc finger zf-Di19 PF05605.12 KII68237.1 - 1.9 8.9 30.8 3.4 8.0 5.9 4.3 2 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zinc-ribbons_6 PF07191.12 KII68237.1 - 3.9 7.5 21.0 6.9 6.7 6.6 3.8 1 1 2 3 3 3 0 zinc-ribbons LIM PF00412.22 KII68237.1 - 4.6 7.6 19.4 1.6 9.0 5.8 3.6 2 1 1 3 3 3 0 LIM domain XPA_N PF01286.18 KII68237.1 - 6.4 6.9 14.6 8.1 6.6 0.3 4.5 4 0 0 4 4 4 0 XPA protein N-terminal Mitofilin PF09731.9 KII68238.1 - 0.039 12.8 0.7 0.054 12.3 0.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein KGK PF08872.10 KII68238.1 - 0.28 11.7 4.5 0.87 10.1 1.4 2.5 2 1 0 2 2 2 0 KGK domain DOCK-C2 PF14429.6 KII68239.1 - 0.0012 18.7 0.1 0.0017 18.2 0.1 1.2 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins MMTV_SAg PF01054.17 KII68239.1 - 0.12 11.9 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen DHR-2 PF06920.13 KII68240.1 - 1.4e-12 47.1 2.5 1.7e-12 46.8 2.5 1.1 1 0 0 1 1 1 1 Dock homology region 2 Thg1C PF14413.6 KII68240.1 - 0.0089 16.2 1.6 0.017 15.3 1.5 1.6 1 1 0 1 1 1 1 Thg1 C terminal domain DUF2465 PF10239.9 KII68240.1 - 0.37 10.0 4.4 0.42 9.8 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) Tetraspanin PF00335.20 KII68241.1 - 2e-17 63.7 1.8 2.5e-17 63.4 1.8 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2207 PF09972.9 KII68241.1 - 0.048 12.4 2.7 0.52 9.0 1.3 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) VEGFR-2_TMD PF17988.1 KII68241.1 - 0.053 13.0 0.4 0.12 11.9 0.4 1.6 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain NAD_Gly3P_dh_C PF07479.14 KII68242.1 - 9.9e-17 61.5 0.0 1e-16 61.5 0.0 1.0 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus YibE_F PF07907.11 KII68245.1 - 0.25 10.8 14.0 0.34 10.4 14.0 1.2 1 0 0 1 1 1 0 YibE/F-like protein GSH_synth_ATP PF03917.17 KII68246.1 - 1.5e-107 359.7 0.0 1.7e-107 359.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 KII68246.1 - 1.7e-25 89.4 0.1 2.5e-24 85.7 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic glutathione synthase DDE_3 PF13358.6 KII68247.1 - 8.1e-09 35.4 0.1 1.1e-08 34.9 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease WAPL PF07814.13 KII68247.1 - 0.026 13.3 0.0 0.026 13.3 0.0 1.0 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin DEAD PF00270.29 KII68248.1 - 6.8e-44 149.7 0.1 1.1e-43 149.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII68248.1 - 3.3e-26 91.8 0.0 2.5e-25 89.0 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KII68248.1 - 1.1e-16 60.7 0.0 2.1e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KII68248.1 - 1.7e-07 31.4 0.1 3.3e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit LPD26 PF18842.1 KII68248.1 - 0.039 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Large polyvalent protein associated domain 26 PhoH PF02562.16 KII68248.1 - 0.058 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein CMS1 PF14617.6 KII68248.1 - 0.061 12.6 0.0 9.5 5.5 0.0 2.5 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit zf-RING_2 PF13639.6 KII68249.1 - 1.3e-11 44.6 7.3 1.3e-11 44.6 7.3 2.2 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 KII68249.1 - 1.2e-07 31.9 9.2 4.9e-07 29.9 9.2 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KII68249.1 - 1.5e-07 31.2 6.3 1.5e-07 31.2 6.3 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KII68249.1 - 1.6e-07 31.0 4.1 1.6e-07 31.0 4.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KII68249.1 - 8.8e-07 28.9 4.3 8.8e-07 28.9 4.3 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KII68249.1 - 8.8e-07 28.7 8.1 8.8e-07 28.7 8.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KII68249.1 - 2.2e-06 27.3 2.3 6.2e-06 25.8 2.3 1.9 1 0 0 1 1 1 1 RING-like zinc finger Prok-RING_4 PF14447.6 KII68249.1 - 9.5e-06 25.4 4.2 2e-05 24.3 4.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KII68249.1 - 0.00034 20.5 6.8 0.00085 19.2 6.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 KII68249.1 - 0.0021 17.6 5.0 0.0021 17.6 5.0 2.1 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 KII68249.1 - 0.024 14.9 6.5 0.024 14.9 6.5 2.0 2 0 0 2 2 2 0 RING-like domain zf-C3HC4_4 PF15227.6 KII68249.1 - 0.13 12.5 10.0 0.05 13.8 5.1 2.6 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-3CxxC_2 PF17180.4 KII68249.1 - 0.14 12.9 3.7 0.23 12.2 3.0 1.7 1 1 0 1 1 1 0 Zinc-binding domain zf-RRPl_C4 PF17026.5 KII68249.1 - 0.68 10.1 7.2 0.55 10.4 1.4 2.6 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type FANCL_C PF11793.8 KII68249.1 - 0.92 9.7 6.6 0.15 12.2 1.6 2.3 2 0 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 KII68249.1 - 3.5 7.8 10.7 0.7 10.1 5.8 2.3 2 0 0 2 2 2 0 RING-variant domain zf-ANAPC11 PF12861.7 KII68249.1 - 3.5 7.7 11.9 0.056 13.5 4.2 2.0 2 1 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Ribosomal_L13 PF00572.18 KII68252.1 - 7.7e-38 129.6 0.0 1e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Rhodanese PF00581.20 KII68254.1 - 5.9e-10 39.6 0.0 8.2e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_11 PF08241.12 KII68255.1 - 1.8e-19 70.2 0.0 2.9e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KII68255.1 - 2.1e-16 60.4 0.0 3.4e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII68255.1 - 2.3e-16 60.1 0.0 2.8e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KII68255.1 - 4.2e-16 59.1 0.0 5.5e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KII68255.1 - 4.1e-14 53.1 0.0 6.5e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KII68255.1 - 1.9e-10 40.5 0.0 2.8e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 KII68255.1 - 1.8e-08 34.1 0.2 3.2e-08 33.3 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 KII68255.1 - 2.1e-07 30.8 0.0 3.2e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 KII68255.1 - 5.9e-07 29.1 0.0 7.4e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 KII68255.1 - 8.2e-07 28.6 0.1 1.3e-06 28.0 0.1 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 KII68255.1 - 1.2e-05 25.0 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 KII68255.1 - 1.9e-05 24.7 0.0 2.7e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 KII68255.1 - 7.2e-05 22.6 0.0 9.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_9 PF08003.11 KII68255.1 - 0.0005 19.1 0.0 0.0007 18.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.12 KII68255.1 - 0.00069 19.3 0.1 0.0018 17.9 0.1 1.6 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 KII68255.1 - 0.0019 18.0 0.0 0.0037 17.1 0.0 1.4 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 KII68255.1 - 0.017 14.7 0.1 0.028 14.0 0.1 1.5 1 1 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_4 PF02390.17 KII68255.1 - 0.023 14.2 0.1 0.083 12.4 0.1 1.8 1 1 1 2 2 2 0 Putative methyltransferase AdoMet_MTase PF07757.13 KII68255.1 - 0.033 14.5 0.0 0.069 13.5 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TPMT PF05724.11 KII68255.1 - 0.035 13.7 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_18 PF12847.7 KII68255.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain ADH_zinc_N PF00107.26 KII68255.1 - 0.16 11.9 0.3 0.69 9.9 0.3 1.9 1 1 0 1 1 1 0 Zinc-binding dehydrogenase GidB PF02527.15 KII68255.1 - 0.17 11.2 0.1 0.3 10.4 0.1 1.4 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G Phage_TAC_3 PF06896.11 KII68255.1 - 0.19 12.3 0.0 0.32 11.6 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, TAC TAFII55_N PF04658.13 KII68256.1 - 9.9e-51 171.6 0.2 1.2e-50 171.3 0.2 1.1 1 0 0 1 1 1 1 TAFII55 protein conserved region gag-asp_proteas PF13975.6 KII68257.1 - 0.0009 19.8 0.0 0.0013 19.2 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII68257.1 - 0.015 15.9 0.0 0.025 15.2 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease Asp_protease PF09668.10 KII68257.1 - 0.02 14.7 0.1 0.043 13.6 0.1 1.5 1 1 0 1 1 1 0 Aspartyl protease EGF_2 PF07974.13 KII68258.1 - 0.0027 18.0 5.6 0.0027 18.0 5.6 2.9 2 0 0 2 2 2 1 EGF-like domain Crystall PF00030.19 KII68258.1 - 0.12 12.5 0.8 0.34 11.1 0.3 2.0 2 0 0 2 2 2 0 Beta/Gamma crystallin DUF572 PF04502.13 KII68259.1 - 1.4e-45 156.3 5.6 1.6e-45 156.2 5.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) RIG-I_C-RD PF11648.8 KII68259.1 - 0.023 14.9 0.7 0.056 13.7 0.1 1.8 1 1 1 2 2 2 0 C-terminal domain of RIG-I ZZ PF00569.17 KII68259.1 - 0.032 14.0 1.2 1.5 8.7 0.1 2.2 2 0 0 2 2 2 0 Zinc finger, ZZ type Zn-ribbon_8 PF09723.10 KII68259.1 - 0.04 14.0 0.4 0.32 11.1 0.1 2.1 2 0 0 2 2 2 0 Zinc ribbon domain zinc_ribbon_9 PF14369.6 KII68259.1 - 0.054 13.7 2.1 2.7 8.3 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon DUF951 PF06107.11 KII68259.1 - 0.059 13.3 0.5 2.6 8.0 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) Esterase_phd PF10503.9 KII68259.1 - 0.12 11.9 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Esterase PHB depolymerase DUF572 PF04502.13 KII68260.1 - 3.2e-12 46.7 6.9 3.4e-12 46.6 6.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Pkinase PF00069.25 KII68262.1 - 1.2e-19 70.8 0.0 1.3e-19 70.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII68262.1 - 1.2e-13 50.9 0.0 1.5e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KII68263.1 - 2.1e-21 76.5 0.0 3.2e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PBD PF00786.28 KII68263.1 - 1.2e-14 54.3 0.1 3.5e-14 52.9 0.1 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_Tyr PF07714.17 KII68263.1 - 3.3e-14 52.8 0.0 5e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RabGAP-TBC PF00566.18 KII68264.1 - 3.7e-10 39.8 2.0 6.2e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain TSP_1 PF00090.19 KII68265.1 - 6.2e-09 35.9 1.8 6.2e-09 35.9 1.8 2.0 2 0 0 2 2 2 1 Thrombospondin type 1 domain Laminin_G_3 PF13385.6 KII68266.1 - 6.5e-16 58.8 0.0 8.5e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.17 KII68266.1 - 0.0021 17.8 0.0 0.0028 17.4 0.0 1.1 1 0 0 1 1 1 1 Pentaxin family Cpn60_TCP1 PF00118.24 KII68267.1 - 1.9e-157 524.9 0.7 2.1e-157 524.7 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PROCN PF08083.11 KII68270.1 - 2e-107 359.5 2.3 3.3e-107 358.7 2.3 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRO8NT PF08082.11 KII68270.1 - 8e-82 272.6 3.0 1.3e-81 271.9 3.0 1.3 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain DDE_Tnp_IS1595 PF12762.7 KII68271.1 - 0.021 14.8 0.1 0.029 14.4 0.1 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain DnaJ PF00226.31 KII68272.1 - 4.4e-16 58.8 0.4 1.2e-15 57.4 0.1 1.9 2 0 0 2 2 2 1 DnaJ domain BNR PF02012.20 KII68273.1 - 0.044 13.8 0.0 0.18 11.9 0.0 2.1 1 0 0 1 1 1 0 BNR/Asp-box repeat Sortilin_C PF15901.5 KII68274.1 - 3.1e-12 47.2 5.0 3.9e-12 46.9 5.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal zf-UBR PF02207.20 KII68275.1 - 2.8e-16 59.4 12.7 2.8e-16 59.4 12.7 2.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ARL2_Bind_BART PF11527.8 KII68275.1 - 1.2 9.3 4.5 13 6.0 0.4 2.9 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART FPL PF09758.9 KII68279.1 - 0.03 14.3 0.2 0.043 13.8 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein GnHR_trans PF12369.8 KII68279.1 - 0.068 14.0 0.4 0.14 13.0 0.3 1.6 1 1 0 1 1 1 0 Gonadotropin hormone receptor transmembrane region NAD_binding_5 PF07994.12 KII68279.1 - 0.069 12.5 0.0 3.1 7.1 0.0 2.0 1 1 1 2 2 2 0 Myo-inositol-1-phosphate synthase Nucleoplasmin PF03066.15 KII68280.1 - 0.0057 17.1 0.6 1.8 9.1 0.1 2.1 2 0 0 2 2 2 2 Nucleoplasmin/nucleophosmin domain IBN_N PF03810.19 KII68280.1 - 0.016 15.1 0.2 0.05 13.5 0.2 2.0 1 1 0 1 1 1 0 Importin-beta N-terminal domain PRELI PF04707.14 KII68280.1 - 0.092 12.6 0.2 1.8 8.4 0.0 2.0 2 0 0 2 2 2 0 PRELI-like family Peptidase_M1 PF01433.20 KII68283.1 - 1.3e-48 165.4 0.3 2.6e-48 164.5 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KII68283.1 - 5.9e-43 147.6 0.0 8.8e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KII68283.1 - 8.3e-14 52.2 5.0 2.5e-13 50.7 0.4 2.6 2 1 1 3 3 3 1 Peptidase M1 N-terminal domain IstB_IS21_ATP PF08483.11 KII68283.1 - 0.0032 17.3 0.5 0.0062 16.4 0.1 1.8 2 0 0 2 2 2 1 IstB-like ATP binding N-terminal DUF1336 PF07059.12 KII68283.1 - 0.032 14.3 0.4 3.9 7.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1336) gag-asp_proteas PF13975.6 KII68284.1 - 0.00021 21.8 0.0 0.0005 20.6 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII68284.1 - 0.00067 20.2 0.0 0.0018 18.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII68284.1 - 0.0016 18.4 2.1 0.0016 18.4 2.1 2.3 2 0 0 2 2 2 1 Zinc knuckle Asp_protease PF09668.10 KII68284.1 - 0.02 14.7 0.1 0.081 12.7 0.1 2.0 1 1 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII68284.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Arf PF00025.21 KII68285.1 - 1e-41 142.3 0.1 1.2e-41 142.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KII68285.1 - 1.7e-16 60.2 0.0 2e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII68285.1 - 8.4e-16 58.3 0.0 1.3e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KII68285.1 - 5e-10 39.1 0.0 6e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KII68285.1 - 1.7e-08 34.0 0.8 3.7e-06 26.4 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KII68285.1 - 7e-07 28.8 0.0 9.1e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KII68285.1 - 7.8e-06 26.0 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 KII68285.1 - 0.0053 16.6 0.2 1.4 8.6 0.0 2.1 1 1 0 2 2 2 2 Conserved hypothetical ATP binding protein TPP_enzyme_N PF02776.18 KII68285.1 - 0.014 15.0 0.0 0.02 14.5 0.0 1.1 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Dynamin_N PF00350.23 KII68285.1 - 0.033 14.2 0.1 0.1 12.7 0.1 1.7 1 1 1 2 2 2 0 Dynamin family AAA_7 PF12775.7 KII68285.1 - 0.044 13.3 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Bax1-I PF01027.20 KII68287.1 - 1.4e-18 67.5 30.6 8.7e-18 64.9 30.6 1.8 1 1 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2070 PF09843.9 KII68287.1 - 8.7 4.5 22.0 11 4.2 22.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Cyclin_N PF00134.23 KII68288.1 - 5.7e-16 58.4 0.3 3.2e-14 52.8 0.2 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 KII68288.1 - 5e-05 23.6 0.1 0.00045 20.6 0.0 2.1 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_C PF02984.19 KII68288.1 - 0.029 14.5 0.8 0.12 12.5 0.1 2.2 1 1 0 2 2 2 0 Cyclin, C-terminal domain DUF3806 PF12713.7 KII68288.1 - 0.061 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3806) Adaptin_N PF01602.20 KII68289.1 - 3e-22 78.9 0.1 3.8e-22 78.6 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KII68289.1 - 0.01 15.9 0.1 0.11 12.5 0.0 2.1 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KII68290.1 - 6.5e-10 38.2 0.6 6.9e-10 38.1 0.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region DUF4923 PF16270.5 KII68290.1 - 0.019 14.8 0.2 0.025 14.4 0.2 1.2 1 0 0 1 1 1 0 Lipocalin-like domain (DUF4923) Ran_BP1 PF00638.18 KII68292.1 - 9.4e-09 35.6 0.0 1.8e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 RanBP1 domain Presenilin PF01080.17 KII68292.1 - 0.48 9.1 2.1 0.52 9.0 2.1 1.1 1 0 0 1 1 1 0 Presenilin DUF5476 PF17570.2 KII68292.1 - 4.4 7.8 7.2 0.23 11.8 1.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5476) DDE_3 PF13358.6 KII68294.1 - 1.2e-17 64.1 0.0 1.6e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII68294.1 - 0.00057 20.1 0.2 0.00094 19.4 0.2 1.4 1 0 0 1 1 1 1 Transposase FH2 PF02181.23 KII68295.1 - 7.3e-85 285.3 14.7 7.3e-85 285.3 14.7 4.0 4 0 0 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 KII68295.1 - 8.5e-31 107.1 0.1 8.5e-31 107.1 0.1 3.9 4 0 0 4 4 4 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 KII68295.1 - 2.3e-17 63.2 2.5 2.3e-17 63.2 2.5 3.3 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Picorna_P3A PF06363.11 KII68295.1 - 0.0052 16.6 0.3 0.017 15.0 0.3 1.8 1 0 0 1 1 1 1 Picornaviridae P3A protein NPV_P10 PF05531.12 KII68295.1 - 0.18 12.3 8.7 1.2 9.7 5.0 3.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Minor_capsid_3 PF12691.7 KII68295.1 - 0.36 11.2 7.7 0.28 11.6 1.6 3.3 2 1 1 3 3 3 0 Minor capsid protein from bacteriophage SlyX PF04102.12 KII68295.1 - 1.7 9.3 7.9 0.69 10.6 1.0 3.9 2 0 0 2 2 2 0 SlyX DUF948 PF06103.11 KII68295.1 - 2.5 8.4 11.4 3.8 7.8 3.8 3.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) COPI_C PF06957.11 KII68296.1 - 4.3e-89 299.1 0.0 5.6e-89 298.7 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 KII68296.1 - 5.6e-81 272.8 4.0 1e-80 272.0 4.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 KII68296.1 - 5.7e-42 140.9 19.4 3.3e-07 30.9 0.2 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat TPR_1 PF00515.28 KII68296.1 - 0.018 14.9 1.5 0.18 11.7 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII68296.1 - 0.028 14.5 2.1 2.5 8.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII68296.1 - 1.4 9.4 3.1 25 5.4 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Spt5-NGN PF03439.13 KII68297.1 - 4.4e-19 68.2 0.0 1.1e-18 66.8 0.0 1.8 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 KII68297.1 - 9.7e-09 34.9 42.3 0.00084 19.2 1.4 7.6 8 0 0 8 8 8 4 KOW motif Spt5_N PF11942.8 KII68297.1 - 3.8e-05 24.6 17.8 3.8e-05 24.6 17.8 2.2 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal DUF3912 PF13051.6 KII68297.1 - 0.0025 18.0 2.3 0.0035 17.6 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3912) DUF4438 PF14505.6 KII68297.1 - 0.016 14.2 0.9 0.15 11.0 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4438) DUF2187 PF09953.9 KII68297.1 - 0.021 14.8 4.4 0.34 10.9 0.4 3.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2187) FYVE PF01363.21 KII68298.1 - 7.3e-08 32.4 14.0 9.2e-07 28.9 13.4 2.6 2 1 0 2 2 2 1 FYVE zinc finger PH PF00169.29 KII68298.1 - 4e-05 24.1 0.5 0.0002 21.8 0.1 2.0 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 KII68298.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain PH_3 PF14593.6 KII68298.1 - 0.13 12.4 0.2 0.21 11.7 0.2 1.3 1 0 0 1 1 1 0 PH domain AAA_23 PF13476.6 KII68299.1 - 3.2e-15 57.2 18.0 3.2e-15 57.2 18.0 4.6 2 2 2 4 4 4 1 AAA domain SMC_N PF02463.19 KII68299.1 - 2.8e-11 43.3 0.1 2.8e-11 43.3 0.1 3.9 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KII68299.1 - 4.7e-05 23.4 2.1 4.7e-05 23.4 2.1 3.4 2 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_27 PF13514.6 KII68299.1 - 0.00066 19.3 0.1 0.00066 19.3 0.1 4.0 5 0 0 5 5 5 1 AAA domain AAA_15 PF13175.6 KII68299.1 - 0.0022 17.8 41.8 0.0022 17.8 41.8 3.4 1 1 0 2 2 2 1 AAA ATPase domain GAS PF13851.6 KII68299.1 - 0.0051 16.2 19.6 0.0051 16.2 19.6 4.7 3 2 1 4 4 4 1 Growth-arrest specific micro-tubule binding AAA_29 PF13555.6 KII68299.1 - 0.012 15.3 0.0 0.032 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_13 PF13166.6 KII68299.1 - 0.04 12.6 0.2 0.04 12.6 0.2 5.0 3 2 2 5 5 5 0 AAA domain SMC_N PF02463.19 KII68300.1 - 8.1e-10 38.5 0.0 9.9e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Sugar_tr PF00083.24 KII68300.1 - 0.059 12.2 0.2 0.07 12.0 0.2 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter SbcCD_C PF13558.6 KII68300.1 - 0.18 12.1 0.0 0.26 11.5 0.0 1.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit PreAtp-grasp PF18604.1 KII68303.1 - 0.026 14.2 0.0 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 Pre ATP-grasp domain Stap_Strp_tox_C PF02876.17 KII68305.1 - 0.11 12.8 4.9 0.62 10.4 0.5 2.2 1 1 1 2 2 2 0 Staphylococcal/Streptococcal toxin, beta-grasp domain GTP_EFTU_D3 PF03143.17 KII68307.1 - 2.8e-23 82.4 0.5 2.1e-12 47.3 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KII68307.1 - 7.2e-14 51.9 0.6 2.1e-13 50.5 0.6 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 KII68307.1 - 1.1e-10 41.5 0.0 7.1e-10 38.7 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.6 KII68307.1 - 0.21 11.5 5.7 0.059 13.3 1.3 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Clat_adaptor_s PF01217.20 KII68308.1 - 0.021 14.8 1.3 0.021 14.8 1.3 1.8 2 0 0 2 2 2 0 Clathrin adaptor complex small chain Adap_comp_sub PF00928.21 KII68309.1 - 6.5e-10 38.8 2.1 7.7e-10 38.6 2.1 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Colipase-like PF15083.6 KII68309.1 - 0.086 13.0 0.5 0.13 12.4 0.5 1.2 1 0 0 1 1 1 0 Colipase-like Ldl_recept_a PF00057.18 KII68311.1 - 1.8e-06 28.0 12.1 1.8e-06 28.0 12.1 4.0 4 0 0 4 4 4 1 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII68311.1 - 0.0002 20.3 0.9 0.00061 18.7 0.0 2.2 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII68311.1 - 0.0088 15.9 0.8 0.3 11.3 0.2 2.9 2 0 0 2 2 2 1 BNR/Asp-box repeat NUP214 PF16755.5 KII68311.1 - 0.47 9.6 7.9 0.32 10.2 0.7 2.3 1 1 1 2 2 2 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 PhoLip_ATPase_N PF16209.5 KII68312.1 - 9.5e-25 86.1 0.5 1.6e-24 85.3 0.5 1.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 KII68312.1 - 0.00052 19.6 1.6 0.00078 19.0 0.1 1.9 1 1 1 2 2 2 1 E1-E2 ATPase PhoLip_ATPase_C PF16212.5 KII68313.1 - 7e-45 153.7 17.3 7e-45 153.7 17.3 1.6 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 KII68313.1 - 1.5e-11 44.2 0.0 6.3e-11 42.2 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KII68313.1 - 3.8e-10 40.4 0.0 0.0042 17.4 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KII68313.1 - 1.6e-05 24.8 0.2 0.001 18.9 0.1 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RhoGEF PF00621.20 KII68314.1 - 2.2e-05 24.8 1.3 2.8e-05 24.4 1.3 1.1 1 0 0 1 1 1 1 RhoGEF domain Flu_B_M2 PF04772.12 KII68314.1 - 0.05 13.8 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) PhoLip_ATPase_N PF16209.5 KII68315.1 - 1.4e-20 72.7 0.1 1.4e-20 72.7 0.1 2.6 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KII68315.1 - 1.2e-12 48.5 0.6 1.1e-06 29.1 0.1 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KII68315.1 - 1.1e-11 44.6 0.0 8.5e-11 41.8 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KII68315.1 - 1.6e-07 31.0 0.1 5e-07 29.4 0.1 1.9 1 1 0 1 1 1 1 E1-E2 ATPase PhoLip_ATPase_C PF16212.5 KII68315.1 - 1.9e-06 27.8 9.6 1.9e-06 27.8 9.6 3.8 2 2 1 3 3 3 2 Phospholipid-translocating P-type ATPase C-terminal Hydrolase_3 PF08282.12 KII68315.1 - 0.00023 21.0 1.4 0.0036 17.1 0.5 2.5 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase ATP13 PF12921.7 KII68317.1 - 0.05 13.5 0.7 0.66 9.9 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial ATPase expression RRP7 PF12923.7 KII68318.1 - 3e-12 46.7 6.6 5e-12 46.0 6.6 1.3 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 KII68318.1 - 3.5e-05 23.6 0.9 6.5e-05 22.8 0.0 1.9 2 1 0 2 2 2 1 Rrp7 RRM-like N-terminal domain NCKAP5 PF15246.6 KII68318.1 - 0.075 12.6 2.2 0.1 12.2 2.2 1.1 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein VirE PF05272.11 KII68319.1 - 0.061 13.1 0.1 0.086 12.6 0.1 1.3 1 0 0 1 1 1 0 Virulence-associated protein E DUF2950 PF11453.8 KII68319.1 - 0.15 11.3 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2950) Med10 PF09748.9 KII68320.1 - 2.5e-16 59.7 0.0 3.6e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex R3H-assoc PF13902.6 KII68321.1 - 0.0002 21.8 1.7 0.00035 21.0 0.0 1.9 1 1 1 2 2 2 1 R3H-associated N-terminal domain ArAE_2_N PF10337.9 KII68321.1 - 0.19 10.7 0.3 0.24 10.4 0.3 1.0 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal PEN-2 PF10251.9 KII68322.1 - 2.5e-19 69.5 0.9 2.9e-19 69.3 0.9 1.0 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase DHHC PF01529.20 KII68322.1 - 0.006 16.7 0.9 0.0075 16.4 0.9 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF1440 PF07274.12 KII68322.1 - 0.15 12.4 0.6 0.21 11.9 0.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1440) OAD_gamma PF04277.13 KII68322.1 - 0.21 12.2 2.0 0.32 11.6 2.0 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Arf PF00025.21 KII68323.1 - 1.2e-50 171.4 0.1 1.5e-50 171.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KII68323.1 - 5e-11 42.9 0.0 6.7e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KII68323.1 - 1e-09 38.0 3.3 4.7e-06 26.0 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KII68323.1 - 1.7e-08 34.2 0.0 2.2e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KII68323.1 - 1.4e-05 24.6 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KII68323.1 - 4.6e-05 22.9 0.0 6e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KII68323.1 - 7.6e-05 22.8 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KII68323.1 - 0.096 12.4 0.0 0.62 9.8 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 KII68323.1 - 0.1 12.7 0.1 1.4 9.0 0.1 2.1 2 0 0 2 2 2 0 Dynamin family CdhD PF03599.16 KII68323.1 - 0.19 10.4 0.0 0.24 10.1 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit Hormone_6 PF00236.18 KII68324.1 - 0.049 13.6 0.7 0.094 12.7 0.4 1.7 1 1 0 1 1 1 0 Glycoprotein hormone HTH_11 PF08279.12 KII68324.1 - 0.096 12.6 0.1 0.76 9.8 0.0 2.0 2 0 0 2 2 2 0 HTH domain Creatininase PF02633.14 KII68324.1 - 0.15 11.5 0.1 0.15 11.5 0.1 1.0 1 0 0 1 1 1 0 Creatinine amidohydrolase Adaptin_N PF01602.20 KII68325.1 - 4.3e-49 167.5 17.2 4.3e-49 167.5 17.2 2.3 2 1 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 KII68325.1 - 6.5e-38 129.6 1.9 2.5e-37 127.7 1.9 2.1 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 KII68325.1 - 1.1e-31 109.6 0.2 2.9e-31 108.2 0.2 1.8 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 KII68325.1 - 7.3e-06 26.3 0.0 0.26 11.7 0.0 4.6 4 1 1 5 5 5 1 HEAT repeats HEAT PF02985.22 KII68325.1 - 0.0016 18.5 0.3 0.59 10.5 0.0 4.6 5 0 0 5 5 5 1 HEAT repeat ArsA_ATPase PF02374.15 KII68325.1 - 0.0039 16.4 0.5 0.01 15.1 0.5 1.6 1 0 0 1 1 1 1 Anion-transporting ATPase KOG2701 PF09762.9 KII68325.1 - 0.082 13.1 0.4 0.21 11.8 0.4 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) FGF PF00167.18 KII68325.1 - 0.097 12.8 0.3 4 7.6 0.0 2.6 2 0 0 2 2 2 0 Fibroblast growth factor Cnd1 PF12717.7 KII68325.1 - 0.2 11.7 16.9 0.23 11.5 0.1 4.7 3 1 2 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Forkhead PF00250.18 KII68327.1 - 5.9e-20 71.3 0.0 1e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain Peptidase_A22B PF04258.13 KII68328.1 - 1.4e-62 211.8 13.9 2.1e-62 211.2 13.9 1.2 1 0 0 1 1 1 1 Signal peptide peptidase Metallophos PF00149.28 KII68329.1 - 3.7e-19 70.0 0.2 6.6e-19 69.2 0.1 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Integrase_H2C2 PF17921.1 KII68330.1 - 1.7e-11 44.0 1.2 3.4e-11 43.1 1.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII68330.1 - 4.4e-10 39.8 0.0 9.5e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII68330.1 - 0.064 13.0 0.1 0.099 12.4 0.1 1.3 1 0 0 1 1 1 0 Integrase core domain RCC1 PF00415.18 KII68331.1 - 9.5e-44 147.8 10.8 5.4e-11 43.0 0.1 6.5 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KII68331.1 - 6.7e-24 83.1 33.7 1.1e-05 25.1 0.2 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat PWI PF01480.17 KII68332.1 - 1e-07 32.2 0.1 3.5e-07 30.4 0.1 1.9 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 KII68332.1 - 1.6e-07 31.0 1.7 0.00087 19.1 0.1 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 KII68332.1 - 0.0005 20.0 0.1 0.045 13.7 0.0 2.4 2 0 0 2 2 2 1 RL domain Nup35_RRM PF05172.13 KII68332.1 - 0.0073 16.2 0.3 1.5 8.9 0.0 2.8 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Torus PF16131.5 KII68332.1 - 0.022 15.5 0.0 0.066 13.9 0.0 1.8 1 0 0 1 1 1 0 Torus domain Nup35_RRM_2 PF14605.6 KII68332.1 - 0.023 14.7 0.1 2.4 8.2 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Ferritin-like PF12902.7 KII68332.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Ferritin-like zf_CCCH_4 PF18345.1 KII68332.1 - 0.075 13.1 5.5 0.15 12.1 5.5 1.6 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 KII68332.1 - 0.46 10.5 3.9 1 9.4 3.9 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KII68332.1 - 0.7 9.8 6.2 1.2 9.0 6.2 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger SspN PF08177.11 KII68332.1 - 0.74 9.8 3.4 8.2 6.5 0.5 2.7 3 0 0 3 3 3 0 Small acid-soluble spore protein N family EMP24_GP25L PF01105.24 KII68333.1 - 5.3e-12 46.1 1.4 7.3e-12 45.6 1.4 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Histone PF00125.24 KII68334.1 - 8e-23 81.2 0.7 1.1e-22 80.7 0.7 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KII68334.1 - 4.8e-06 26.8 0.0 1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KII68334.1 - 0.004 17.6 0.0 0.0072 16.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KII68334.1 - 0.024 14.7 0.1 0.032 14.3 0.1 1.3 1 0 0 1 1 1 0 YscO-like protein Med7 PF05983.11 KII68335.1 - 3.4e-38 131.7 0.9 2.4e-37 128.9 0.9 1.9 1 1 0 1 1 1 1 MED7 protein BORCS7 PF16088.5 KII68335.1 - 0.046 14.0 1.4 0.086 13.1 1.4 1.5 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 HBM PF16591.5 KII68335.1 - 0.052 13.0 0.5 0.23 10.9 0.4 1.8 2 0 0 2 2 2 0 Helical bimodular sensor domain PRANC PF09372.10 KII68335.1 - 0.064 13.6 0.6 0.064 13.6 0.6 1.8 2 1 0 2 2 2 0 PRANC domain Sec8_exocyst PF04048.14 KII68335.1 - 0.14 12.1 4.1 0.33 10.8 1.6 2.2 1 1 0 2 2 2 0 Sec8 exocyst complex component specific domain CorA PF01544.18 KII68335.1 - 0.25 10.6 4.3 1.5 8.0 0.3 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Polyketide_cyc PF03364.20 KII68336.1 - 4.2e-12 46.4 0.0 5.9e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport ATP-synt_ab PF00006.25 KII68337.1 - 4.4e-62 209.5 0.0 6.5e-62 208.9 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KII68337.1 - 2.8e-21 75.8 1.9 6.3e-21 74.7 1.9 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain NB-ARC PF00931.22 KII68337.1 - 0.0029 16.8 0.2 0.011 14.9 0.0 1.9 2 0 0 2 2 2 1 NB-ARC domain ATPase_2 PF01637.18 KII68337.1 - 0.017 15.1 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ATPase PF06745.13 KII68337.1 - 0.033 13.5 0.1 0.058 12.7 0.1 1.4 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 KII68337.1 - 0.039 13.9 0.1 0.099 12.5 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 KII68337.1 - 0.045 14.2 0.1 1.3 9.5 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII68337.1 - 0.051 14.0 0.1 0.15 12.4 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 KII68337.1 - 0.06 13.7 1.0 0.41 11.0 0.2 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KII68337.1 - 0.063 13.2 0.2 0.2 11.6 0.0 1.8 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 KII68337.1 - 0.1 13.0 0.0 0.31 11.5 0.0 1.8 2 0 0 2 2 1 0 RNA helicase DUF2075 PF09848.9 KII68337.1 - 0.2 10.9 0.1 0.37 10.0 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) T3SS_ATPase_C PF18269.1 KII68337.1 - 0.2 11.5 0.6 0.77 9.7 0.6 2.0 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain UBA_4 PF14555.6 KII68338.1 - 5.9e-09 35.6 0.5 9.6e-09 34.9 0.5 1.3 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 KII68338.1 - 8.4e-05 22.1 0.3 0.00015 21.4 0.3 1.4 1 0 0 1 1 1 1 TAP C-terminal domain Thioredoxin_7 PF13899.6 KII68338.1 - 0.0042 17.2 0.0 0.0098 16.1 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like Sigma70_r1_1 PF03979.14 KII68339.1 - 0.04 14.0 0.4 0.11 12.6 0.4 1.7 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 Peptidase_C97 PF05903.14 KII68344.1 - 6.1e-33 113.8 0.3 7.4e-33 113.5 0.3 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain PP1_inhibitor PF05361.12 KII68344.1 - 0.027 14.5 0.0 0.04 13.9 0.0 1.2 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor LRAT PF04970.13 KII68344.1 - 0.047 14.0 0.0 0.055 13.8 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase DnaB PF00772.21 KII68344.1 - 0.13 12.4 0.1 26 5.0 0.0 2.4 2 0 0 2 2 2 0 DnaB-like helicase N terminal domain Sec1 PF00995.23 KII68345.1 - 1.1e-61 209.8 0.4 1.4e-61 209.5 0.4 1.0 1 0 0 1 1 1 1 Sec1 family DUF3741 PF12552.8 KII68345.1 - 0.18 11.8 2.0 0.94 9.5 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3741) Peptidase_M14 PF00246.24 KII68346.1 - 1.5e-42 146.4 0.3 2.4e-42 145.7 0.3 1.3 1 1 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 KII68346.1 - 2.8e-10 40.3 0.0 4.2e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 KII68346.1 - 0.00013 21.9 0.0 0.0002 21.3 0.0 1.2 1 0 0 1 1 1 1 CarboxypepD_reg-like domain LisH_TPL PF17814.1 KII68347.1 - 0.2 11.4 0.6 0.47 10.2 0.6 1.7 1 0 0 1 1 1 0 LisH-like dimerisation domain Med23 PF11573.8 KII68348.1 - 1e-31 109.6 28.3 1.4e-31 109.2 28.3 1.2 1 0 0 1 1 1 1 Mediator complex subunit 23 BspA_v PF18220.1 KII68349.1 - 0.018 15.1 0.1 0.023 14.8 0.1 1.3 1 0 0 1 1 1 0 Adhesin BspA variable domain TIP49 PF06068.13 KII68350.1 - 5.4e-152 506.0 0.3 7.1e-152 505.6 0.3 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KII68350.1 - 1.3e-16 60.4 1.0 4.1e-16 58.9 1.0 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 KII68350.1 - 5.5e-13 49.5 1.3 6.9e-08 33.0 0.0 2.9 2 1 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KII68350.1 - 1.3e-11 44.5 0.0 1.7e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KII68350.1 - 2.4e-08 34.3 0.6 0.0084 16.4 0.1 2.7 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 KII68350.1 - 1.4e-07 32.1 0.2 0.0011 19.3 0.0 2.6 3 0 0 3 3 2 2 AAA ATPase domain AAA_5 PF07728.14 KII68350.1 - 3.2e-07 30.4 1.3 0.0032 17.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KII68350.1 - 1.4e-06 27.8 0.0 0.00022 20.7 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 KII68350.1 - 1e-05 25.9 0.4 0.091 13.1 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 KII68350.1 - 0.00078 19.5 0.0 0.45 10.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KII68350.1 - 0.00097 18.9 0.0 0.0026 17.5 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 KII68350.1 - 0.0011 18.8 0.0 0.31 10.7 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.6 KII68350.1 - 0.0016 18.7 0.0 0.0037 17.5 0.0 1.6 2 0 0 2 2 1 1 AAA domain Parvo_NS1 PF01057.17 KII68350.1 - 0.0019 17.4 0.0 0.0033 16.6 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 ResIII PF04851.15 KII68350.1 - 0.003 17.6 0.1 0.15 12.0 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_25 PF13481.6 KII68350.1 - 0.0032 17.1 0.0 0.0062 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 KII68350.1 - 0.0035 16.7 0.1 0.009 15.4 0.0 1.7 2 0 0 2 2 1 1 DnaB-like helicase C terminal domain AAA_7 PF12775.7 KII68350.1 - 0.0064 16.0 0.0 0.027 14.0 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 KII68350.1 - 0.0093 16.5 0.0 0.031 14.8 0.0 1.9 2 0 0 2 2 1 1 AAA domain ABC_tran PF00005.27 KII68350.1 - 0.011 16.3 0.0 0.039 14.5 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_30 PF13604.6 KII68350.1 - 0.011 15.4 0.1 0.42 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 KII68350.1 - 0.024 14.1 0.1 0.065 12.7 0.1 1.7 1 0 0 1 1 1 0 PhoH-like protein MCM PF00493.23 KII68350.1 - 0.032 13.3 0.1 5.5 6.0 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain AAA_33 PF13671.6 KII68350.1 - 0.043 14.0 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KII68350.1 - 0.052 12.8 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 KII68350.1 - 0.055 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 KII68350.1 - 0.057 12.6 0.1 5.6 6.0 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase NACHT PF05729.12 KII68350.1 - 0.062 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Baculo_PEP_C PF04513.12 KII68350.1 - 0.076 13.1 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TniB PF05621.11 KII68350.1 - 0.1 12.0 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein TsaE PF02367.17 KII68350.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 KII68350.1 - 0.12 12.8 0.0 0.36 11.2 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Zeta_toxin PF06414.12 KII68350.1 - 0.14 11.4 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 KII68350.1 - 0.14 11.8 0.0 0.43 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain Homeodomain PF00046.29 KII68351.1 - 6.3e-20 70.8 0.6 1.1e-19 70.0 0.6 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KII68351.1 - 0.23 11.4 1.7 0.31 11.0 0.1 2.1 2 0 0 2 2 2 0 Homeobox KN domain Como_SCP PF02248.16 KII68352.1 - 0.017 14.7 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Small coat protein GCV_T_C PF08669.11 KII68352.1 - 0.071 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain SH3_1 PF00018.28 KII68353.1 - 3.8e-56 186.5 2.0 1.6e-15 56.5 0.0 4.1 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.6 KII68353.1 - 1.3e-50 169.0 0.1 2.6e-12 46.4 0.0 4.1 4 0 0 4 4 4 4 Variant SH3 domain SH3_2 PF07653.17 KII68353.1 - 3.8e-37 125.8 0.0 1.5e-10 40.6 0.0 4.1 4 0 0 4 4 4 4 Variant SH3 domain SH3_10 PF17902.1 KII68353.1 - 7.3e-14 51.6 0.3 0.0026 17.8 0.0 4.1 4 0 0 4 4 4 4 SH3 domain hSH3 PF14603.6 KII68353.1 - 4.3e-10 39.9 0.0 0.0075 16.7 0.0 4.0 4 0 0 4 4 4 3 Helically-extended SH3 domain DUF4889 PF16230.5 KII68353.1 - 0.00062 19.9 0.1 0.52 10.6 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4889) Acetone_carb_G PF08882.11 KII68353.1 - 0.0021 18.2 0.0 4.2 7.5 0.0 3.5 3 1 1 4 4 4 1 Acetone carboxylase gamma subunit SH3_3 PF08239.11 KII68353.1 - 0.0027 17.9 0.6 1.2 9.4 0.0 3.8 4 0 0 4 4 4 1 Bacterial SH3 domain Aldo_ket_red PF00248.21 KII68355.1 - 2.1e-29 102.7 0.0 2.4e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FYVE PF01363.21 KII68356.1 - 2.4e-10 40.4 19.2 1.1e-09 38.3 19.2 2.0 1 1 0 1 1 1 1 FYVE zinc finger PH_13 PF16652.5 KII68356.1 - 0.0029 17.4 0.1 0.012 15.4 0.0 1.8 1 1 1 2 2 2 1 Pleckstrin homology domain PH PF00169.29 KII68356.1 - 0.005 17.3 0.8 0.011 16.3 0.2 1.9 2 1 0 2 2 2 1 PH domain UNC-79 PF14776.6 KII68356.1 - 7.7 5.1 11.2 12 4.5 11.2 1.2 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 GCV_H PF01597.19 KII68357.1 - 1.6e-34 118.4 0.4 3.4e-34 117.3 0.4 1.5 1 1 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 KII68357.1 - 0.0039 17.0 0.2 0.0062 16.3 0.2 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme zinc_ribbon_10 PF10058.9 KII68358.1 - 4.4e-09 35.9 0.0 7.7e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein GST_C_3 PF14497.6 KII68360.1 - 0.0036 17.5 0.2 0.018 15.2 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain SNO PF01174.19 KII68361.1 - 0.032 14.1 0.1 0.038 13.8 0.1 1.2 1 0 0 1 1 1 0 SNO glutamine amidotransferase family AAA PF00004.29 KII68362.1 - 7.8e-29 100.8 0.0 1.6e-28 99.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KII68362.1 - 6.9e-05 22.6 0.0 0.00016 21.5 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KII68362.1 - 0.00049 20.1 0.2 0.028 14.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KII68362.1 - 0.00063 20.0 0.1 0.003 17.8 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII68362.1 - 0.017 15.5 0.0 0.031 14.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 KII68362.1 - 0.028 13.8 0.1 0.062 12.7 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KII68362.1 - 0.061 13.1 0.1 0.16 11.7 0.1 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 KII68362.1 - 0.064 12.8 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 KII68362.1 - 0.11 11.9 0.1 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 KaiC Sigma54_activat PF00158.26 KII68362.1 - 0.11 12.2 0.1 0.92 9.2 0.0 2.3 2 1 1 3 3 3 0 Sigma-54 interaction domain AAA_18 PF13238.6 KII68362.1 - 0.11 13.0 0.1 0.29 11.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KII68362.1 - 0.2 11.2 0.2 0.82 9.2 0.0 2.0 2 1 1 3 3 3 0 AAA domain PTR2 PF00854.21 KII68363.1 - 4.2e-16 58.8 1.9 3e-13 49.4 0.3 2.3 2 0 0 2 2 2 2 POT family Vac_Fusion PF02346.16 KII68364.1 - 0.048 13.3 1.6 0.3 10.8 0.6 2.7 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 GP41 PF00517.17 KII68364.1 - 0.17 11.8 4.4 0.6 10.0 0.0 3.0 3 0 0 3 3 3 0 Retroviral envelope protein RSD-2 PF07547.13 KII68364.1 - 3.5 8.2 7.6 4.9 7.7 0.1 3.6 3 1 1 4 4 3 0 RSD-2 N-terminal domain PSP1 PF04468.12 KII68365.1 - 0.025 14.8 0.1 0.096 13.0 0.0 2.0 2 1 0 2 2 2 0 PSP1 C-terminal conserved region Adap_comp_sub PF00928.21 KII68366.1 - 6.8e-22 78.1 0.3 9.2e-22 77.7 0.3 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KII68366.1 - 2.1e-05 24.5 0.6 0.00014 21.8 0.0 2.3 1 1 1 2 2 2 1 Clathrin adaptor complex small chain Serpin PF00079.20 KII68367.1 - 1.5e-47 162.8 5.0 1.6e-47 162.6 5.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) OPA3 PF07047.12 KII68368.1 - 5.7e-35 119.8 0.1 8.4e-35 119.3 0.1 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Flu_PB1 PF00602.17 KII68368.1 - 0.069 11.2 0.1 5.1 5.1 0.0 2.0 2 0 0 2 2 2 0 Influenza RNA-dependent RNA polymerase subunit PB1 Glyco_transf_10 PF00852.19 KII68369.1 - 1.4e-40 138.9 4.5 1.4e-40 138.9 4.5 1.5 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DUF1160 PF06648.11 KII68369.1 - 0.04 13.9 1.2 0.39 10.7 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1160) BshC PF10079.9 KII68369.1 - 0.083 11.6 2.8 0.52 9.0 0.1 2.6 2 1 1 3 3 3 0 Bacillithiol biosynthesis BshC Glyco_transf_10 PF00852.19 KII68370.1 - 5.9e-41 140.1 1.4 7.1e-41 139.8 1.4 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Folate_rec PF03024.14 KII68371.1 - 7.1e-33 113.9 22.5 9.5e-33 113.5 22.5 1.1 1 0 0 1 1 1 1 Folate receptor family Folate_rec PF03024.14 KII68372.1 - 5.3e-10 39.4 0.7 6.1e-10 39.2 0.7 1.0 1 0 0 1 1 1 1 Folate receptor family Folate_rec PF03024.14 KII68373.1 - 1.1e-30 106.7 18.2 1.3e-30 106.6 18.2 1.0 1 0 0 1 1 1 1 Folate receptor family Conotoxin PF02950.17 KII68373.1 - 0.15 13.1 0.2 0.15 13.1 0.2 2.7 2 1 0 2 2 2 0 Conotoxin AdoHcyase PF05221.17 KII68374.1 - 4e-20 72.1 0.0 4e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KII68374.1 - 4.8e-15 56.0 0.2 6.3e-15 55.6 0.2 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KII68374.1 - 0.0057 16.0 0.1 0.0088 15.4 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UPF0180 PF03698.13 KII68374.1 - 0.046 13.9 0.1 0.074 13.2 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) AdoHcyase PF05221.17 KII68375.1 - 1.1e-81 274.2 0.0 6.5e-47 160.1 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KII68375.1 - 1.9e-58 197.1 0.3 3.3e-58 196.3 0.3 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KII68375.1 - 2.5e-10 40.0 0.1 4.3e-10 39.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KII68375.1 - 2.4e-05 24.0 0.2 3.7e-05 23.4 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.19 KII68375.1 - 0.00045 19.6 0.3 0.0014 17.9 0.3 1.8 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 KII68375.1 - 0.0034 17.8 0.2 0.025 15.0 0.1 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 KII68375.1 - 0.0065 16.5 0.0 0.045 13.8 0.0 2.3 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 KII68375.1 - 0.022 15.0 0.1 0.047 13.9 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain ELFV_dehydrog PF00208.21 KII68375.1 - 0.041 13.6 0.1 0.065 12.9 0.1 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TAF4 PF05236.14 KII68376.1 - 1.3e-06 28.4 10.1 2.8e-05 24.0 10.1 2.3 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family DUF4269 PF14091.6 KII68376.1 - 0.1 12.8 2.0 3.4 7.9 0.1 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4269) Kdo_hydroxy PF11004.8 KII68378.1 - 0.17 11.1 0.1 14 4.8 0.0 2.2 2 0 0 2 2 2 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase Mrr_N PF14338.6 KII68378.1 - 0.19 11.9 0.0 35 4.6 0.0 2.3 2 0 0 2 2 2 0 Mrr N-terminal domain Stealth_CR2 PF11380.8 KII68378.1 - 0.63 10.2 4.5 16 5.7 0.3 2.4 2 0 0 2 2 2 0 Stealth protein CR2, conserved region 2 DDE_Tnp_IS1595 PF12762.7 KII68379.1 - 2.5e-10 40.6 0.0 3.1e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Tfb2 PF03849.14 KII68380.1 - 0.2 10.6 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Transcription factor Tfb2 S4 PF01479.25 KII68381.1 - 2.9e-09 36.5 0.4 7.4e-09 35.2 0.4 1.7 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 KII68381.1 - 1.3e-06 29.2 0.8 8.1e-06 26.7 0.3 2.2 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Ras PF00071.22 KII68382.1 - 1.1e-64 217.0 3.3 1.2e-64 216.8 3.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII68382.1 - 1.1e-37 128.8 1.1 1.9e-37 128.2 1.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII68382.1 - 2.2e-18 66.3 0.6 2.7e-18 66.0 0.6 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII68382.1 - 6.9e-07 28.9 0.9 9.4e-07 28.4 0.9 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KII68382.1 - 1.5e-05 25.1 0.3 2.4e-05 24.4 0.3 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KII68382.1 - 3.3e-05 23.9 2.0 0.12 12.3 0.6 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KII68382.1 - 3.6e-05 23.4 1.6 4.7e-05 23.0 1.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KII68382.1 - 6.3e-05 22.5 0.3 8.6e-05 22.0 0.3 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 KII68382.1 - 0.00029 20.7 0.7 0.00036 20.4 0.1 1.4 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein TniB PF05621.11 KII68382.1 - 0.011 15.1 0.0 0.068 12.6 0.0 2.1 1 1 1 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 KII68382.1 - 0.028 14.9 0.2 0.051 14.1 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 KII68382.1 - 0.033 13.7 0.4 0.095 12.2 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 KII68382.1 - 0.045 14.1 0.0 0.079 13.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 KII68382.1 - 0.067 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rcd1 PF04078.13 KII68383.1 - 6.6e-14 51.8 1.6 8e-14 51.5 1.6 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Rcd1 PF04078.13 KII68384.1 - 8e-15 54.8 2.2 1e-14 54.5 2.2 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like RabGAP-TBC PF00566.18 KII68385.1 - 2.4e-28 99.3 0.1 3.2e-28 98.9 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Prp18 PF02840.15 KII68386.1 - 1.8e-43 148.0 2.4 2e-34 118.7 0.1 2.8 2 1 1 3 3 3 2 Prp18 domain DUF5310 PF17237.2 KII68387.1 - 0.034 14.0 0.1 0.11 12.4 0.1 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5310) Hum_adeno_E3A PF05393.11 KII68387.1 - 0.075 13.0 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein ETRAMP PF09716.10 KII68387.1 - 0.13 12.3 0.1 0.33 11.1 0.1 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PRP4 PF08799.11 KII68388.1 - 6.1e-09 35.3 0.0 9.4e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Flavodoxin_3 PF12641.7 KII68388.1 - 0.038 13.7 1.0 0.052 13.2 1.0 1.1 1 0 0 1 1 1 0 Flavodoxin domain TerB PF05099.13 KII68388.1 - 0.058 13.4 0.6 0.071 13.1 0.6 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TerB NUC153 PF08159.12 KII68389.1 - 7.9e-07 28.8 2.9 1.9e-06 27.5 2.9 1.7 1 0 0 1 1 1 1 NUC153 domain PQQ_3 PF13570.6 KII68389.1 - 0.037 14.5 0.0 0.085 13.4 0.0 1.6 1 0 0 1 1 1 0 PQQ-like domain WD40 PF00400.32 KII68389.1 - 0.053 14.4 1.8 19 6.4 0.0 3.8 4 0 0 4 4 4 0 WD domain, G-beta repeat MBOAT PF03062.19 KII68392.1 - 3.9e-17 62.6 18.5 5e-17 62.3 18.5 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 KII68392.1 - 0.0077 16.5 1.5 0.0077 16.5 1.5 2.0 2 1 0 2 2 2 1 Membrane bound O-acyl transferase family DDE_1 PF03184.19 KII68393.1 - 0.093 12.4 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease CDH-cyt PF16010.5 KII68395.1 - 0.03 14.0 0.7 0.058 13.1 0.2 1.5 1 1 1 2 2 2 0 Cytochrome domain of cellobiose dehydrogenase Annexin PF00191.20 KII68399.1 - 1.3e-13 50.8 2.2 0.033 14.3 0.1 4.4 4 0 0 4 4 4 4 Annexin Sortilin-Vps10 PF15902.5 KII68401.1 - 0.0031 16.4 0.4 0.18 10.6 0.5 2.0 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII68401.1 - 0.019 14.9 1.7 0.068 13.2 0.4 2.4 2 0 0 2 2 2 0 BNR/Asp-box repeat Ldl_recept_a PF00057.18 KII68402.1 - 2.1e-09 37.4 20.1 1.4e-07 31.6 10.0 2.7 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Glycophorin_A PF01102.18 KII68402.1 - 0.0095 16.2 0.2 0.016 15.4 0.2 1.3 1 0 0 1 1 1 1 Glycophorin A RT_RNaseH_2 PF17919.1 KII68404.1 - 4.9e-34 116.3 0.0 9.3e-34 115.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII68404.1 - 2.4e-33 114.6 0.1 5.3e-33 113.5 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII68404.1 - 1e-16 61.2 0.0 2.8e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 KII68404.1 - 5.4e-16 58.8 0.1 9e-16 58.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII68404.1 - 1.2e-14 54.1 0.3 3.2e-14 52.8 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII68404.1 - 0.011 15.9 0.0 0.031 14.5 0.0 1.8 1 0 0 1 1 1 0 H2C2 zinc finger MLVIN_C PF18697.1 KII68405.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain TEX15 PF15326.6 KII68405.1 - 0.073 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Testis expressed sequence 15 Orf78 PF06024.12 KII68406.1 - 0.014 15.6 0.1 0.021 15.1 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Chordopox_A13L PF05961.11 KII68406.1 - 0.019 15.2 0.3 0.036 14.3 0.3 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Glycophorin_A PF01102.18 KII68406.1 - 0.022 15.0 0.1 0.023 14.9 0.1 1.3 1 0 0 1 1 1 0 Glycophorin A Shisa PF13908.6 KII68406.1 - 0.035 14.4 0.3 0.039 14.2 0.3 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Ldl_recept_a PF00057.18 KII68406.1 - 0.042 14.1 2.5 0.07 13.4 2.5 1.3 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A Stevor PF17410.2 KII68406.1 - 0.099 12.2 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame MHYT PF03707.16 KII68406.1 - 0.13 12.4 0.4 0.2 11.9 0.4 1.2 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat TPPK_C PF12555.8 KII68406.1 - 0.14 12.2 2.0 0.2 11.7 2.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal TMEM132D_C PF15706.5 KII68406.1 - 0.15 11.9 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Syndecan PF01034.20 KII68406.1 - 0.33 10.9 1.5 0.49 10.4 1.5 1.3 1 0 0 1 1 1 0 Syndecan domain Sortilin-Vps10 PF15902.5 KII68408.1 - 4.1e-12 45.6 0.1 5.1e-10 38.7 0.0 2.0 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII68408.1 - 0.0027 17.4 6.4 0.1 12.6 0.4 3.2 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_2 PF13088.6 KII68408.1 - 0.045 13.0 0.0 0.097 11.9 0.0 1.5 1 1 0 1 1 1 0 BNR repeat-like domain LLGL PF08366.13 KII68408.1 - 0.049 14.0 0.0 0.062 13.6 0.0 1.2 1 0 0 1 1 1 0 LLGL2 rve PF00665.26 KII68414.1 - 0.016 15.4 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS1595 PF12762.7 KII68415.1 - 3.5e-05 23.8 0.1 6e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain Antigen_C PF16364.5 KII68415.1 - 0.031 14.7 0.1 0.043 14.2 0.1 1.2 1 0 0 1 1 1 0 Cell surface antigen C-terminus DDE_3 PF13358.6 KII68416.1 - 9e-05 22.3 0.0 0.0024 17.6 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_1 PF03184.19 KII68418.1 - 1.2e-35 122.8 0.0 1.3e-35 122.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII68418.1 - 0.011 15.5 0.0 0.029 14.1 0.0 1.6 1 1 0 2 2 2 0 DDE superfamily endonuclease RVT_1 PF00078.27 KII68419.1 - 7.4e-10 38.7 0.1 9e-10 38.4 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tfb5 PF06331.12 KII68419.1 - 0.094 12.7 0.3 0.14 12.2 0.3 1.3 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 RNase_T PF00929.24 KII68421.1 - 0.022 15.3 0.2 0.071 13.7 0.2 1.8 1 1 0 1 1 1 0 Exonuclease RT_RNaseH PF17917.1 KII68422.1 - 9.2e-13 48.4 0.2 2.5e-12 47.0 0.1 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII68422.1 - 9.3e-12 44.9 0.0 2.6e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII68422.1 - 0.00068 19.8 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Kunitz_BPTI PF00014.23 KII68423.1 - 0.0025 18.0 16.2 0.004 17.4 9.7 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain rve PF00665.26 KII68424.1 - 4.1e-10 39.9 0.0 5.3e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII68424.1 - 0.0052 16.5 0.0 0.0086 15.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII68424.1 - 0.14 11.9 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Endothelin PF00322.17 KII68425.1 - 0.017 14.7 3.7 0.23 11.1 1.1 2.7 2 0 0 2 2 2 0 Endothelin family Kunitz_BPTI PF00014.23 KII68425.1 - 0.19 12.0 11.0 0.051 13.8 4.2 2.8 2 2 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain Tetraspanin PF00335.20 KII68426.1 - 9.4e-17 61.5 10.1 1.2e-16 61.2 10.1 1.1 1 0 0 1 1 1 1 Tetraspanin family ABC_tran PF00005.27 KII68427.1 - 0.00046 20.7 0.0 0.00076 20.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ERAP1_C PF11838.8 KII68428.1 - 5e-50 170.8 0.2 5.8e-50 170.6 0.2 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Colicin_D PF11429.8 KII68428.1 - 0.051 14.0 0.0 0.38 11.2 0.0 2.2 2 0 0 2 2 2 0 Colicin D Peptidase_M1 PF01433.20 KII68429.1 - 0.00039 20.0 0.1 0.00052 19.6 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain RNHCP PF12647.7 KII68429.1 - 0.036 14.0 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 RNHCP domain Peptidase_M1 PF01433.20 KII68430.1 - 1.1e-17 64.4 0.0 1.3e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KII68431.1 - 1.7e-07 31.1 0.0 1.9e-07 30.9 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain DUF3922 PF13059.6 KII68431.1 - 0.083 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) ERAP1_C PF11838.8 KII68432.1 - 1.1e-13 51.5 0.0 1.1e-13 51.4 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KII68433.1 - 4.5e-36 124.8 6.2 5.9e-36 124.4 6.2 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 KII68434.1 - 6.4e-33 114.6 0.0 7.8e-33 114.4 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 KII68435.1 - 0.0015 18.1 0.1 0.0026 17.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KII68436.1 - 2.6e-35 122.3 4.5 3.5e-35 121.9 4.5 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 KII68436.1 - 5e-25 88.3 0.0 1.3e-24 87.0 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M1 domain ARID PF01388.21 KII68437.1 - 3.8e-12 46.7 0.2 1e-11 45.3 0.2 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tudor-knot PF11717.8 KII68437.1 - 5.7e-08 32.5 0.2 1.3e-07 31.4 0.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain MBT PF02820.18 KII68437.1 - 0.0016 18.8 0.5 0.43 11.0 0.1 3.3 2 1 1 3 3 3 1 mbt repeat Chromo PF00385.24 KII68437.1 - 0.0069 16.3 0.0 0.021 14.7 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ets PF00178.22 KII68438.1 - 1.2e-19 70.5 0.3 5.7e-19 68.4 0.2 2.0 2 0 0 2 2 2 1 Ets-domain ASFV_p27 PF06556.11 KII68438.1 - 0.057 13.5 0.2 0.082 13.0 0.2 1.3 1 0 0 1 1 1 0 IAP-like protein p27 C-terminus Reticulon PF02453.17 KII68439.1 - 2.7e-14 53.4 10.9 3.6e-14 53.0 10.9 1.2 1 0 0 1 1 1 1 Reticulon FtsH_ext PF06480.15 KII68439.1 - 0.23 11.8 1.3 0.48 10.8 1.3 1.6 1 0 0 1 1 1 0 FtsH Extracellular GWT1 PF06423.12 KII68439.1 - 0.23 11.6 3.0 0.31 11.2 2.5 1.4 1 1 0 1 1 1 0 GWT1 MMR_HSR1_Xtn PF16897.5 KII68440.1 - 2.9e-29 101.2 1.3 3.7e-29 100.9 1.3 1.1 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Rieske PF00355.26 KII68441.1 - 3e-11 43.1 0.1 6.4e-11 42.1 0.1 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 KII68441.1 - 0.0029 18.1 0.0 0.0057 17.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region FXa_inhibition PF14670.6 KII68441.1 - 0.33 11.3 2.5 0.73 10.2 2.5 1.5 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site Nefa_Nip30_N PF10187.9 KII68442.1 - 3.6e-09 36.9 16.6 6.3e-09 36.1 16.6 1.4 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 ORF6N PF10543.9 KII68442.1 - 8.4 6.7 8.0 56 4.0 8.0 2.1 1 1 0 1 1 1 0 ORF6N domain PHO4 PF01384.20 KII68443.1 - 5.2e-53 180.2 0.9 5.5e-53 180.2 0.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family Prefoldin_2 PF01920.20 KII68449.1 - 1.3e-11 44.4 3.8 2.1e-11 43.7 3.8 1.4 1 1 0 1 1 1 1 Prefoldin subunit CCDC-167 PF15188.6 KII68449.1 - 0.01 16.2 1.0 0.01 16.2 1.0 2.2 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF4686 PF15742.5 KII68449.1 - 0.034 13.3 8.5 0.084 12.0 2.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) DUF3847 PF12958.7 KII68449.1 - 0.058 13.5 6.4 2.3 8.4 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) Prefoldin PF02996.17 KII68449.1 - 0.071 13.0 0.4 0.071 13.0 0.4 2.4 1 1 0 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.8 KII68449.1 - 0.91 9.6 5.1 3.2 7.8 0.6 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Ribosomal_S15 PF00312.22 KII68450.1 - 7.9e-08 32.4 2.4 1.5e-07 31.5 2.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S15 TUTF7_u4 PF16631.5 KII68450.1 - 0.0043 17.6 0.1 0.0086 16.7 0.1 1.5 1 0 0 1 1 1 1 Unstructured region 4 on terminal uridylyltransferase 7 Integrase_H2C2 PF17921.1 KII68451.1 - 1.9e-07 31.1 0.1 3.4e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII68451.1 - 0.00072 19.7 0.0 0.0034 17.6 0.0 2.2 2 0 0 2 2 2 1 H2C2 zinc finger rve PF00665.26 KII68451.1 - 0.0047 17.1 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain PIF1 PF05970.14 KII68452.1 - 2.2e-33 115.9 0.4 2.7e-33 115.7 0.4 1.1 1 0 0 1 1 1 1 PIF1-like helicase UvrD_C_2 PF13538.6 KII68452.1 - 4.3e-07 29.6 0.0 1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 KII68452.1 - 6.6e-06 24.4 0.0 9.1e-06 23.9 0.0 1.1 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 KII68452.1 - 0.00072 19.4 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase PIF1 PF05970.14 KII68453.1 - 1.5e-36 126.3 0.0 2.2e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 KII68453.1 - 4.5e-10 39.6 0.0 8e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KII68453.1 - 5.8e-05 23.5 0.0 0.00017 22.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KII68453.1 - 0.00033 20.9 0.1 0.0028 17.9 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII68453.1 - 0.02 15.3 0.0 0.084 13.2 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain ResIII PF04851.15 KII68453.1 - 0.022 14.7 0.1 0.054 13.5 0.1 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 KII68453.1 - 0.023 14.7 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KII68453.1 - 0.056 13.5 0.0 0.28 11.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain DUF2791 PF10923.8 KII68453.1 - 0.063 12.1 0.1 0.094 11.5 0.1 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) AFG1_ATPase PF03969.16 KII68453.1 - 0.071 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase Helitron_like_N PF14214.6 KII68454.1 - 3.5e-16 60.0 7.9 1.8e-15 57.7 0.0 3.1 3 1 0 3 3 3 2 Helitron helicase-like domain at N-terminus DUF4507 PF14964.6 KII68456.1 - 3.8e-18 65.5 0.0 8.3e-18 64.4 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4507) SEA PF01390.20 KII68457.1 - 6.4e-06 26.2 1.3 1.9e-05 24.7 1.3 1.8 1 0 0 1 1 1 1 SEA domain FLYWCH PF04500.16 KII68459.1 - 3.9e-17 62.1 2.0 1.3e-16 60.4 2.0 2.0 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII68459.1 - 1.2e-14 54.5 0.0 2.3e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain NIF PF03031.18 KII68460.1 - 1.3e-26 93.3 0.3 2.5e-26 92.3 0.3 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 KII68460.1 - 0.0018 18.6 0.0 0.0064 16.9 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KII68460.1 - 0.0069 16.3 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain Fur_reg_FbpA PF13076.6 KII68460.1 - 0.96 9.2 2.9 44 3.9 1.8 2.6 2 0 0 2 2 2 0 Fur-regulated basic protein A NOT2_3_5 PF04153.18 KII68461.1 - 1.4e-27 96.3 6.4 1.6e-27 96.2 6.4 1.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DNA_pol_D_N PF18018.1 KII68462.1 - 2.9e-21 75.9 0.7 3.5e-21 75.7 0.7 1.1 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain FSIP1 PF15554.6 KII68462.1 - 0.073 12.2 0.6 0.11 11.6 0.4 1.3 1 1 0 1 1 1 0 FSIP1 family LRR19-TM PF15176.6 KII68462.1 - 0.091 12.8 0.5 0.19 11.7 0.5 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DNA_pol_E_B PF04042.16 KII68463.1 - 2.2e-26 92.5 0.2 2.7e-26 92.2 0.2 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Syja_N PF02383.18 KII68466.1 - 9.2e-72 242.0 0.5 1.3e-71 241.5 0.5 1.2 1 0 0 1 1 1 1 SacI homology domain FlgN PF05130.12 KII68466.1 - 0.055 14.0 0.6 0.14 12.7 0.6 1.7 1 0 0 1 1 1 0 FlgN protein DUF1624 PF07786.12 KII68466.1 - 0.072 12.6 0.4 2 7.9 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1624) KH_1 PF00013.29 KII68468.1 - 1.3e-11 44.1 0.0 2.2e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 KII68468.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 KH domain DUF1864 PF08933.11 KII68469.1 - 0.015 14.0 0.1 0.019 13.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1864) Mga PF05043.13 KII68469.1 - 0.034 14.7 2.2 0.04 14.5 1.0 1.8 2 0 0 2 2 2 0 Mga helix-turn-helix domain DUF5420 PF17457.2 KII68469.1 - 0.058 13.3 0.0 0.11 12.4 0.0 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5420) DUF1492 PF07374.11 KII68469.1 - 0.089 13.0 0.5 0.15 12.2 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) Glyco_transf_18 PF15024.6 KII68470.1 - 3.3e-20 72.2 2.9 3.7e-20 72.0 2.9 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 18 RT_RNaseH PF17917.1 KII68470.1 - 0.015 15.6 0.0 0.87 9.9 0.0 2.2 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase DEK_C PF08766.11 KII68470.1 - 0.13 12.3 0.0 0.64 10.0 0.0 2.1 2 0 0 2 2 2 0 DEK C terminal domain RsgA_GTPase PF03193.16 KII68471.1 - 0.0068 16.3 0.0 0.0071 16.3 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 KII68471.1 - 0.011 16.2 0.0 0.021 15.3 0.0 1.5 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 KII68471.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 KII68471.1 - 0.045 13.3 0.1 0.052 13.0 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 KII68471.1 - 0.049 12.8 0.0 0.056 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) T2SSE PF00437.20 KII68471.1 - 0.13 11.3 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein G-alpha PF00503.20 KII68471.1 - 0.18 10.9 0.1 0.22 10.7 0.1 1.1 1 0 0 1 1 1 0 G-protein alpha subunit GST_C_6 PF17171.4 KII68472.1 - 4.6e-07 29.5 0.0 8.9e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 KII68472.1 - 0.015 15.6 0.0 0.042 14.2 0.0 1.8 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Na_Ca_ex PF01699.24 KII68473.1 - 3.3e-09 36.9 0.8 5e-09 36.3 0.8 1.2 1 0 0 1 1 1 1 Sodium/calcium exchanger protein RPA_C PF08784.11 KII68474.1 - 7.9e-11 42.5 0.1 1.9e-10 41.3 0.0 1.7 2 0 0 2 2 2 1 Replication protein A C terminal DUF4105 PF13387.6 KII68474.1 - 0.045 13.4 0.1 0.4 10.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4105) CH PF00307.31 KII68476.1 - 2.8e-06 27.5 1.1 4.5e-06 26.8 1.1 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain EB1 PF03271.17 KII68476.1 - 7.7e-06 26.1 1.2 2.5e-05 24.4 1.2 1.9 1 0 0 1 1 1 1 EB1-like C-terminal motif CH_2 PF06294.11 KII68476.1 - 0.015 15.4 0.7 0.025 14.7 0.7 1.4 1 0 0 1 1 1 0 CH-like domain in sperm protein D123 PF07065.14 KII68479.1 - 3.1e-34 118.5 1.6 4e-29 101.7 0.1 2.1 1 1 1 2 2 2 2 D123 IU_nuc_hydro PF01156.19 KII68480.1 - 3.4e-43 148.4 0.0 4.2e-43 148.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase LAP2alpha PF11560.8 KII68480.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha DDE_Tnp_IS1595 PF12762.7 KII68482.1 - 4.1e-15 56.1 0.1 6.3e-15 55.5 0.1 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Sortilin_C PF15901.5 KII68483.1 - 3.6e-10 40.4 0.8 4.1e-10 40.3 0.8 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin_C PF15901.5 KII68484.1 - 4.1e-14 53.3 0.8 4.1e-14 53.3 0.8 1.8 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII68484.1 - 8.7e-08 31.4 2.7 2.2e-07 30.1 2.7 1.6 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, zf-RING-like PF08746.11 KII68484.1 - 0.0033 17.7 0.2 0.014 15.6 0.2 2.2 1 0 0 1 1 1 1 RING-like domain BNR PF02012.20 KII68484.1 - 0.0073 16.1 10.2 1.6 9.0 0.0 4.8 4 0 0 4 4 4 1 BNR/Asp-box repeat Rad10 PF03834.14 KII68485.1 - 0.09 12.8 0.3 0.13 12.2 0.3 1.3 1 1 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) DUF1492 PF07374.11 KII68485.1 - 0.094 12.9 0.4 0.18 12.0 0.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1492) DUF2321 PF10083.9 KII68485.1 - 0.12 12.0 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Sortilin-Vps10 PF15902.5 KII68490.1 - 0.00041 19.3 1.7 0.0009 18.1 1.7 1.5 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, GerE PF00196.19 KII68491.1 - 0.023 14.2 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family DDE_3 PF13358.6 KII68491.1 - 0.036 13.8 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF3099 PF11298.8 KII68492.1 - 0.12 12.5 0.3 0.12 12.5 0.3 3.0 3 2 0 3 3 3 0 Protein of unknown function (DUF3099) DUF4293 PF14126.6 KII68492.1 - 0.24 11.6 9.9 0.16 12.2 5.8 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4293) Rsm22 PF09243.10 KII68497.1 - 0.031 13.6 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 PA28_beta PF02252.18 KII68499.1 - 1.5e-47 160.9 0.2 3e-47 160.0 0.0 1.6 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 KII68499.1 - 0.00046 20.2 0.0 0.00094 19.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit MutS_V PF00488.21 KII68501.1 - 6.5e-05 23.0 0.0 8.1e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 MutS domain V TAFH PF07531.14 KII68501.1 - 0.018 15.1 0.1 0.026 14.6 0.1 1.2 1 0 0 1 1 1 0 NHR1 homology to TAF Annexin PF00191.20 KII68503.1 - 1.2e-05 25.3 2.7 0.00041 20.4 0.2 3.2 3 0 0 3 3 3 2 Annexin DDE_Tnp_IS1595 PF12762.7 KII68504.1 - 2.7e-07 30.7 0.0 2.4e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF4389 PF14333.6 KII68506.1 - 0.083 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) DUF5621 PF18532.1 KII68507.1 - 0.064 13.2 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5621) Kelch_6 PF13964.6 KII68508.1 - 1.4e-27 95.0 13.7 5e-05 23.4 0.1 6.1 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII68508.1 - 2.2e-25 88.4 8.1 8.9e-05 22.4 0.0 5.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII68508.1 - 1.6e-19 69.2 6.8 0.0033 17.0 0.0 6.4 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.6 KII68508.1 - 1e-17 63.9 7.1 0.0028 17.9 0.0 5.9 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KII68508.1 - 1.2e-11 44.1 7.9 0.013 15.4 0.1 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 KII68508.1 - 5.1e-09 35.9 11.1 0.23 11.5 0.0 5.9 6 0 0 6 6 6 4 Kelch motif DUF3128 PF11326.8 KII68508.1 - 0.018 15.4 0.2 12 6.3 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3128) DDE_1 PF03184.19 KII68509.1 - 0.00017 21.3 0.1 0.00032 20.4 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease MULE PF10551.9 KII68511.1 - 0.0025 18.2 0.1 0.004 17.5 0.1 1.4 1 0 0 1 1 1 1 MULE transposase domain Kelch_1 PF01344.25 KII68512.1 - 3e-23 81.1 4.2 4e-08 32.7 0.1 3.1 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 KII68512.1 - 1.8e-16 59.8 7.3 3.1e-05 24.1 0.1 3.5 2 1 1 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII68512.1 - 1.3e-12 47.7 3.1 0.0017 18.6 0.3 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII68512.1 - 1.7e-11 43.9 5.1 0.00024 21.0 0.2 3.7 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII68512.1 - 7.6e-10 38.4 6.3 0.0047 16.9 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII68512.1 - 0.00017 21.5 5.9 0.2 11.7 0.0 3.5 3 1 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 KII68513.1 - 1.3e-05 24.7 0.6 0.001 18.6 0.3 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 KII68513.1 - 0.026 14.8 1.7 0.095 13.0 0.2 2.2 1 1 1 2 2 2 0 Kelch motif AIMP2_LysRS_bd PF16780.5 KII68514.1 - 0.12 12.1 0.2 0.23 11.2 0.2 1.4 1 0 0 1 1 1 0 AIMP2 lysyl-tRNA synthetase binding domain Eco57I PF07669.11 KII68521.1 - 0.16 12.5 2.0 0.34 11.5 0.8 2.1 2 0 0 2 2 2 0 Eco57I restriction-modification methylase DDE_3 PF13358.6 KII68524.1 - 2.6e-10 40.2 0.1 4.1e-10 39.6 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.11 KII68524.1 - 0.02 13.9 0.1 0.031 13.3 0.1 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain MIF4G_like PF09088.11 KII68529.1 - 0.079 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 MIF4G like Serpin PF00079.20 KII68531.1 - 2.1e-18 66.8 1.5 2.2e-18 66.7 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) TIMELESS PF04821.14 KII68531.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.3 1 1 0 1 1 1 0 Timeless protein rve PF00665.26 KII68535.1 - 3.8e-22 78.7 0.0 7.9e-22 77.7 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII68535.1 - 0.00023 20.9 0.0 0.00079 19.1 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain DDE_3 PF13358.6 KII68537.1 - 1.9e-12 47.2 0.1 2.4e-12 46.8 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease AdoHcyase PF05221.17 KII68538.1 - 2.3e-10 40.1 0.2 2.9e-08 33.2 0.1 2.8 1 1 2 3 3 3 2 S-adenosyl-L-homocysteine hydrolase Glyco_transf_24 PF18404.1 KII68538.1 - 0.028 13.8 0.1 0.044 13.2 0.1 1.2 1 0 0 1 1 1 0 Glucosyltransferase 24 Serpin PF00079.20 KII68539.1 - 6.9e-16 58.5 0.1 8.5e-16 58.2 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) E_raikovi_mat PF06360.11 KII68541.1 - 0.33 11.4 7.1 0.77 10.2 1.0 2.4 2 1 0 2 2 2 0 Euplotes raikovi mating pheromone RT_RNaseH_2 PF17919.1 KII68544.1 - 0.014 15.4 0.2 0.048 13.7 0.0 1.9 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase Citrate_synt PF00285.21 KII68550.1 - 1.2e-13 50.9 0.0 8.6e-13 48.1 0.0 1.8 1 1 0 1 1 1 1 Citrate synthase, C-terminal domain TRI9 PF08195.11 KII68551.1 - 0.025 14.5 0.1 0.052 13.4 0.1 1.5 1 0 0 1 1 1 0 TRI9 protein DDE_3 PF13358.6 KII68553.1 - 0.023 14.4 0.0 0.046 13.5 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease MLVIN_C PF18697.1 KII68554.1 - 0.00025 21.1 0.0 0.00037 20.5 0.0 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DDE_3 PF13358.6 KII68556.1 - 7e-24 84.2 0.0 9.3e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII68556.1 - 0.0015 18.2 0.0 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease ssDNA_DBD PF18333.1 KII68557.1 - 0.078 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain Arm PF00514.23 KII68558.1 - 0.00026 20.9 0.2 0.41 10.8 0.1 4.0 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KII68558.1 - 0.058 13.9 0.0 1.9 9.1 0.0 2.3 2 0 0 2 2 2 0 HEAT-like repeat SUD-M PF11633.8 KII68558.1 - 0.059 13.1 0.2 0.11 12.2 0.2 1.4 1 1 0 1 1 1 0 Single-stranded poly(A) binding domain Arm PF00514.23 KII68559.1 - 2.5e-10 40.0 4.5 0.0038 17.2 0.2 3.6 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat MOZART2 PF12926.7 KII68559.1 - 0.035 13.7 0.0 0.069 12.8 0.0 1.4 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated HEAT_2 PF13646.6 KII68559.1 - 0.035 14.5 0.0 0.19 12.1 0.0 2.1 1 1 1 2 2 2 0 HEAT repeats Phage_spike_2 PF18781.1 KII68559.1 - 0.11 12.6 0.1 0.32 11.1 0.0 1.8 2 0 0 2 2 2 0 Phage spike trimer HEAT_EZ PF13513.6 KII68559.1 - 0.13 12.8 0.1 0.69 10.5 0.1 2.2 1 1 1 2 2 2 0 HEAT-like repeat DDE_Tnp_IS1595 PF12762.7 KII68560.1 - 5.2e-07 29.8 0.1 6.3e-07 29.5 0.1 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Rep_fac-A_C PF08646.10 KII68561.1 - 2.4e-35 121.4 0.2 5e-35 120.4 0.1 1.6 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KII68561.1 - 1.4e-23 82.6 0.5 9.1e-23 80.0 1.2 2.0 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 KII68561.1 - 0.0016 18.3 0.1 0.64 10.0 0.0 3.2 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain IBR PF01485.21 KII68561.1 - 0.025 14.8 1.4 0.053 13.7 1.4 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zinc-ribbons_6 PF07191.12 KII68561.1 - 1.1 9.3 3.3 0.46 10.5 0.7 1.7 2 0 0 2 2 2 0 zinc-ribbons S4 PF01479.25 KII68563.1 - 2.9e-09 36.5 0.4 7.4e-09 35.2 0.4 1.7 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 KII68563.1 - 2e-06 28.6 2.1 9.2e-06 26.5 0.8 2.5 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain SPARC_Ca_bdg PF10591.9 KII68565.1 - 0.042 14.2 0.1 0.074 13.4 0.1 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region SLC3A2_N PF16028.5 KII68566.1 - 0.034 13.7 3.3 1.3 8.6 0.1 2.2 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus DUF2207 PF09972.9 KII68572.1 - 0.2 10.4 0.5 0.23 10.2 0.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 KII68572.1 - 0.36 10.9 2.9 0.57 10.2 2.9 1.3 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DDE_3 PF13358.6 KII68573.1 - 0.0028 17.4 0.0 0.0038 17.0 0.0 1.2 1 1 0 1 1 1 1 DDE superfamily endonuclease Ras PF00071.22 KII68575.1 - 5.9e-51 172.3 0.1 6.8e-51 172.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII68575.1 - 1.8e-20 73.3 0.0 3.2e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII68575.1 - 1.6e-10 40.7 0.0 2.1e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KII68575.1 - 2.8e-05 23.8 0.3 9.2e-05 22.1 0.0 1.7 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF2666 PF10869.8 KII68576.1 - 0.034 14.4 0.9 0.79 9.9 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) VEGF_C PF14554.6 KII68577.1 - 0.12 12.5 0.6 0.26 11.4 0.6 1.6 1 0 0 1 1 1 0 VEGF heparin-binding domain FAM76 PF16046.5 KII68578.1 - 0.035 13.5 6.6 0.045 13.1 6.6 1.1 1 0 0 1 1 1 0 FAM76 protein rve PF00665.26 KII68579.1 - 2.7e-10 40.5 0.1 5.9e-10 39.4 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII68579.1 - 0.00022 21.0 0.5 0.0037 17.0 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain DUF5344 PF17279.2 KII68579.1 - 0.068 13.8 1.1 2.9 8.6 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5344) Integrase_H2C2 PF17921.1 KII68580.1 - 2.9e-08 33.7 0.1 5e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII68580.1 - 0.0054 16.9 0.2 0.37 11.0 0.0 3.1 4 0 0 4 4 4 1 H2C2 zinc finger DrrA_P4M PF14860.6 KII68580.1 - 0.012 15.5 0.1 0.013 15.3 0.1 1.2 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain SUI1 PF01253.22 KII68580.1 - 0.092 13.3 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor SUI1 Defensin_beta PF00711.19 KII68581.1 - 0.62 10.1 2.9 0.39 10.8 0.9 1.6 2 0 0 2 2 2 0 Beta defensin HMMR_N PF15905.5 KII68582.1 - 0.00026 20.6 17.4 0.0013 18.3 17.8 1.7 1 1 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.9 KII68582.1 - 0.0011 18.9 14.6 0.0021 18.1 14.6 1.5 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 KII68582.1 - 0.0012 19.3 12.3 0.14 12.6 2.2 2.0 1 1 1 2 2 2 2 Fez1 MscS_porin PF12795.7 KII68582.1 - 0.0024 17.5 4.7 0.0029 17.2 4.6 1.4 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain THOC7 PF05615.13 KII68582.1 - 0.0031 17.8 14.5 0.074 13.3 9.8 2.5 1 1 1 2 2 2 1 Tho complex subunit 7 Fib_alpha PF08702.10 KII68582.1 - 0.0069 16.6 6.2 0.0069 16.6 6.2 2.4 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family ERM PF00769.19 KII68582.1 - 0.011 15.6 9.0 0.013 15.4 9.0 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family PspA_IM30 PF04012.12 KII68582.1 - 0.012 15.3 9.7 0.48 10.0 1.9 2.2 1 1 1 2 2 2 0 PspA/IM30 family DUF2353 PF09789.9 KII68582.1 - 0.013 14.9 1.1 0.013 14.9 1.1 2.1 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) DUF4795 PF16043.5 KII68582.1 - 0.014 15.0 3.7 0.014 15.0 3.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) ABC_tran_CTD PF16326.5 KII68582.1 - 0.034 14.4 16.5 2.1 8.6 0.3 3.2 2 1 1 3 3 3 0 ABC transporter C-terminal domain BRE1 PF08647.11 KII68582.1 - 0.035 14.2 11.8 0.053 13.6 3.3 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase OmpH PF03938.14 KII68582.1 - 0.038 14.3 9.4 0.081 13.3 9.4 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4472 PF14739.6 KII68582.1 - 0.054 14.2 11.1 0.11 13.3 3.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) NPV_P10 PF05531.12 KII68582.1 - 0.069 13.6 1.8 0.31 11.5 0.4 2.2 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Phage_HK97_TLTM PF06120.11 KII68582.1 - 0.071 12.3 10.5 0.11 11.7 10.5 1.2 1 0 0 1 1 1 0 Tail length tape measure protein ADIP PF11559.8 KII68582.1 - 0.071 13.2 13.4 1.1 9.3 2.9 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding HemX PF04375.14 KII68582.1 - 0.077 12.3 8.4 1.2 8.3 1.0 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Golgin_A5 PF09787.9 KII68582.1 - 0.11 12.0 13.8 0.15 11.5 13.8 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DivIC PF04977.15 KII68582.1 - 0.11 12.3 15.3 1.5 8.6 0.2 3.5 1 1 1 3 3 3 0 Septum formation initiator GAS PF13851.6 KII68582.1 - 0.12 11.8 15.4 0.67 9.3 8.2 2.1 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 KII68582.1 - 0.12 12.8 18.8 0.89 10.0 9.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) FAM76 PF16046.5 KII68582.1 - 0.12 11.7 10.2 0.14 11.5 10.2 1.1 1 0 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 KII68582.1 - 0.2 10.7 13.3 1.1 8.2 12.8 1.9 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_DNA_bd PF12329.8 KII68582.1 - 0.24 11.4 17.3 0.65 10.0 0.7 3.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding TSC22 PF01166.18 KII68582.1 - 0.25 11.7 11.9 0.47 10.8 0.1 3.5 1 1 3 4 4 4 0 TSC-22/dip/bun family DUF3450 PF11932.8 KII68582.1 - 0.25 10.6 12.0 0.024 13.9 3.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ZapB PF06005.12 KII68582.1 - 0.28 11.6 16.3 3.6 8.1 8.7 3.0 1 1 1 2 2 2 0 Cell division protein ZapB TMPIT PF07851.13 KII68582.1 - 0.31 10.2 10.9 1.6 7.9 10.9 1.8 1 1 0 1 1 1 0 TMPIT-like protein Tropomyosin_1 PF12718.7 KII68582.1 - 0.35 11.0 16.7 1.1 9.4 5.7 2.2 1 1 1 2 2 2 0 Tropomyosin like DUF4140 PF13600.6 KII68582.1 - 0.37 11.2 7.8 3.1 8.3 1.1 2.8 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF948 PF06103.11 KII68582.1 - 0.38 11.0 3.1 1 9.7 0.6 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 KII68582.1 - 0.4 9.5 16.0 1.6 7.5 15.0 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF724 PF05266.14 KII68582.1 - 0.54 10.1 13.8 35 4.2 5.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Sec2p PF06428.11 KII68582.1 - 0.58 10.2 11.1 0.42 10.6 3.2 2.6 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p STAT_alpha PF01017.20 KII68582.1 - 0.58 10.0 11.9 0.066 13.1 3.4 2.0 1 1 1 2 2 2 0 STAT protein, all-alpha domain DUF4047 PF13256.6 KII68582.1 - 0.62 10.3 10.7 0.27 11.4 8.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) ATG16 PF08614.11 KII68582.1 - 0.67 10.2 12.3 0.87 9.8 3.9 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Lip_prot_lig_C PF10437.9 KII68582.1 - 0.68 10.0 6.0 1.1 9.3 0.5 2.8 1 1 2 3 3 3 0 Bacterial lipoate protein ligase C-terminus RPW8 PF05659.11 KII68582.1 - 0.68 9.6 6.6 9 6.0 1.2 2.8 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF641 PF04859.12 KII68582.1 - 0.73 10.2 10.5 0.2 12.0 5.3 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Csm1_N PF18504.1 KII68582.1 - 0.78 10.1 14.9 1.7 9.1 0.4 3.9 1 1 3 4 4 4 0 Csm1 N-terminal domain TRAF_BIRC3_bd PF16673.5 KII68582.1 - 0.79 9.6 12.7 1.4 8.8 2.0 3.3 2 1 1 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain DUF2203 PF09969.9 KII68582.1 - 0.81 10.4 10.0 1.6 9.4 3.8 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Macoilin PF09726.9 KII68582.1 - 0.93 8.0 12.4 1.1 7.8 12.4 1.0 1 0 0 1 1 1 0 Macoilin family AAA_13 PF13166.6 KII68582.1 - 1.1 7.8 13.7 3.3 6.2 13.7 1.7 1 1 0 1 1 1 0 AAA domain CALCOCO1 PF07888.11 KII68582.1 - 1.3 7.8 14.7 5 5.9 14.8 1.8 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like USP8_interact PF08941.10 KII68582.1 - 1.4 8.7 6.5 1.5 8.6 1.2 2.0 1 1 1 2 2 2 0 USP8 interacting CENP-H PF05837.12 KII68582.1 - 1.5 9.2 12.0 1.4 9.3 7.4 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 KII68582.1 - 1.8 8.7 8.5 4 7.5 5.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PRKG1_interact PF15898.5 KII68582.1 - 1.8 9.5 11.2 3.1 8.7 9.8 1.9 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain APG6_N PF17675.1 KII68582.1 - 1.9 9.0 14.8 10 6.7 14.5 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF812 PF05667.11 KII68582.1 - 1.9 7.2 16.6 3.6 6.3 16.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Swi5 PF07061.11 KII68582.1 - 2 8.5 14.4 1.4 9.1 3.1 3.5 2 1 1 3 3 3 0 Swi5 DASH_Spc34 PF08657.10 KII68582.1 - 2.3 7.9 14.4 8.8 6.0 14.2 1.9 1 1 0 1 1 1 0 DASH complex subunit Spc34 Uso1_p115_C PF04871.13 KII68582.1 - 2.6 8.4 11.7 7.9 6.9 2.6 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region UPF0242 PF06785.11 KII68582.1 - 3.5 7.7 17.4 4.3 7.4 17.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MetOD2 PF18548.1 KII68582.1 - 4.1 7.6 12.9 1.9 8.6 1.3 3.0 1 1 2 3 3 3 0 Metanogen output domain 2 V_ATPase_I PF01496.19 KII68582.1 - 5.5 4.8 10.0 6.6 4.5 10.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EnY2 PF10163.9 KII68583.1 - 0.036 14.4 0.7 0.036 14.4 0.7 1.5 2 0 0 2 2 2 0 Transcription factor e(y)2 THOC7 PF05615.13 KII68583.1 - 0.12 12.7 7.8 0.14 12.4 2.2 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 Fib_alpha PF08702.10 KII68583.1 - 0.3 11.3 6.9 0.52 10.5 6.9 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF5638 PF18688.1 KII68583.1 - 0.54 10.6 9.6 1 9.7 9.3 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5638) CEP209_CC5 PF16574.5 KII68583.1 - 0.97 9.6 8.6 2.4 8.3 8.2 1.8 1 1 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 CENP-F_leu_zip PF10473.9 KII68584.1 - 6.9e-06 26.1 13.6 0.011 15.7 9.6 2.2 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 KII68584.1 - 0.00022 20.6 15.0 0.00084 18.7 14.8 1.7 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Macoilin PF09726.9 KII68584.1 - 0.00027 19.7 10.7 0.00033 19.4 10.7 1.0 1 0 0 1 1 1 1 Macoilin family Occludin_ELL PF07303.13 KII68584.1 - 0.0014 19.3 8.5 0.033 14.9 7.0 2.1 1 1 1 2 2 2 1 Occludin homology domain MAD PF05557.13 KII68584.1 - 0.0017 16.8 14.0 0.0019 16.6 14.0 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF724 PF05266.14 KII68584.1 - 0.0025 17.7 14.3 0.065 13.1 14.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF724) Spc7 PF08317.11 KII68584.1 - 0.0031 16.4 14.7 0.011 14.6 14.7 1.7 1 1 0 1 1 1 1 Spc7 kinetochore protein BRE1 PF08647.11 KII68584.1 - 0.0043 17.1 12.5 0.061 13.4 1.5 2.1 1 1 1 2 2 2 2 BRE1 E3 ubiquitin ligase DUF4618 PF15397.6 KII68584.1 - 0.013 14.9 10.6 0.036 13.5 10.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) THOC7 PF05615.13 KII68584.1 - 0.022 15.0 14.4 0.024 14.9 4.8 2.4 1 1 1 2 2 2 0 Tho complex subunit 7 FAM76 PF16046.5 KII68584.1 - 0.023 14.1 9.2 0.026 13.9 9.2 1.0 1 0 0 1 1 1 0 FAM76 protein BLOC1_2 PF10046.9 KII68584.1 - 0.027 14.8 7.3 0.67 10.3 2.0 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fez1 PF06818.15 KII68584.1 - 0.039 14.4 11.2 0.31 11.5 11.2 1.9 1 1 0 1 1 1 0 Fez1 Asp2 PF16929.5 KII68584.1 - 0.041 12.8 3.4 0.046 12.7 3.4 1.0 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter DUF4164 PF13747.6 KII68584.1 - 0.06 13.6 1.0 0.06 13.6 1.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) TSC22 PF01166.18 KII68584.1 - 0.067 13.5 9.5 0.29 11.5 1.6 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family KELK PF15796.5 KII68584.1 - 0.069 13.6 12.9 1.5 9.3 5.8 2.8 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FliJ PF02050.16 KII68584.1 - 0.07 13.4 12.5 14 5.9 11.6 2.5 1 1 1 2 2 2 0 Flagellar FliJ protein Uso1_p115_C PF04871.13 KII68584.1 - 0.08 13.3 8.5 0.42 11.0 2.5 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region ABC_tran_CTD PF16326.5 KII68584.1 - 0.085 13.1 11.9 0.87 9.9 0.2 3.2 2 1 1 3 3 3 0 ABC transporter C-terminal domain KI67R PF08065.12 KII68584.1 - 0.093 13.3 1.9 0.12 12.9 1.6 1.3 1 1 0 1 1 1 0 KI67R (NUC007) repeat Exonuc_VII_L PF02601.15 KII68584.1 - 0.099 12.2 6.6 0.12 12.0 6.6 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4094 PF13334.6 KII68584.1 - 0.1 13.1 9.5 1.1 9.7 2.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) DUF745 PF05335.13 KII68584.1 - 0.1 12.3 4.7 0.2 11.4 4.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF4472 PF14739.6 KII68584.1 - 0.1 13.3 10.5 0.046 14.5 4.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Meis_PKNOX_N PF16493.5 KII68584.1 - 0.11 12.8 3.4 0.1 13.0 1.7 1.7 1 1 1 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 CLZ PF16526.5 KII68584.1 - 0.12 12.7 6.3 1 9.8 0.6 2.9 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4200 PF13863.6 KII68584.1 - 0.16 12.4 17.7 2.2 8.7 5.9 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DivIC PF04977.15 KII68584.1 - 0.16 11.7 11.9 1.2 9.0 0.1 3.5 1 1 2 3 3 3 0 Septum formation initiator TMF_DNA_bd PF12329.8 KII68584.1 - 0.19 11.7 15.6 8.5 6.5 0.4 3.9 1 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding MCU PF04678.13 KII68584.1 - 0.28 11.2 3.6 0.37 10.9 3.6 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF948 PF06103.11 KII68584.1 - 0.3 11.4 1.3 4.9 7.5 0.4 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 KII68584.1 - 0.36 11.0 13.1 0.14 12.3 5.5 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ATG16 PF08614.11 KII68584.1 - 0.37 11.0 12.4 1.3 9.2 5.8 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) PHM7_cyt PF14703.6 KII68584.1 - 0.38 11.0 11.9 1.9 8.7 11.9 1.9 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter PRKG1_interact PF15898.5 KII68584.1 - 0.39 11.6 10.4 0.41 11.6 8.9 1.7 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Spc42p PF11544.8 KII68584.1 - 0.43 10.6 13.5 1.4 8.9 6.2 2.2 2 0 0 2 2 2 0 Spindle pole body component Spc42p IMD PF08397.11 KII68584.1 - 0.49 9.7 13.0 0.9 8.9 4.4 2.0 1 1 1 2 2 2 0 IRSp53/MIM homology domain Plk4_PB2 PF18409.1 KII68584.1 - 0.53 11.0 7.2 0.29 11.8 2.3 2.0 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 Vac_Fusion PF02346.16 KII68584.1 - 0.56 9.9 7.2 0.66 9.6 0.1 2.9 2 1 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Tropomyosin_1 PF12718.7 KII68584.1 - 0.61 10.2 15.2 1.9 8.7 1.5 2.2 1 1 1 2 2 2 0 Tropomyosin like CP12 PF02672.15 KII68584.1 - 0.69 10.7 5.9 0.76 10.6 1.9 2.5 1 1 2 3 3 3 0 CP12 domain DUF4140 PF13600.6 KII68584.1 - 0.76 10.2 7.6 7.9 7.0 0.2 2.8 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) Tup_N PF08581.10 KII68584.1 - 0.77 10.1 16.9 0.56 10.6 7.8 2.3 1 1 1 2 2 2 0 Tup N-terminal TMPIT PF07851.13 KII68584.1 - 0.78 8.9 12.0 2.8 7.1 11.1 1.8 1 1 1 2 2 2 0 TMPIT-like protein DASH_Spc34 PF08657.10 KII68584.1 - 0.9 9.3 13.0 1.7 8.3 13.0 1.6 1 1 0 1 1 1 0 DASH complex subunit Spc34 USP8_interact PF08941.10 KII68584.1 - 0.94 9.3 9.4 0.86 9.4 3.5 2.0 1 1 1 2 2 2 0 USP8 interacting Seryl_tRNA_N PF02403.22 KII68584.1 - 0.96 9.7 11.3 3.3 8.0 1.3 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Phage_GP20 PF06810.11 KII68584.1 - 1.1 9.1 11.2 3.5 7.4 11.2 1.8 1 1 0 1 1 1 0 Phage minor structural protein GP20 CREPT PF16566.5 KII68584.1 - 1.1 9.4 8.5 5.4 7.2 1.7 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Atg14 PF10186.9 KII68584.1 - 1.2 8.2 14.2 4.1 6.4 14.0 1.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fmp27_WPPW PF10359.9 KII68584.1 - 1.6 7.5 12.9 2.4 6.9 11.9 1.6 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain APG6_N PF17675.1 KII68584.1 - 1.7 9.2 14.3 14 6.2 14.4 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region Sec2p PF06428.11 KII68584.1 - 2.2 8.3 10.2 3 7.9 0.2 2.4 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p MetOD2 PF18548.1 KII68584.1 - 2.4 8.3 11.0 1.5 9.0 4.3 3.2 1 1 3 4 4 4 0 Metanogen output domain 2 DUF4795 PF16043.5 KII68584.1 - 2.4 7.7 12.4 0.98 9.0 5.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF3450 PF11932.8 KII68584.1 - 2.5 7.3 11.8 0.68 9.2 4.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Cep57_CLD_2 PF14197.6 KII68584.1 - 2.6 8.2 9.8 26 5.0 7.4 2.4 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 UPF0242 PF06785.11 KII68584.1 - 3.8 7.6 16.0 5.3 7.1 16.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 KII68584.1 - 4.2 7.4 9.0 27 4.8 6.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HAUS6_N PF14661.6 KII68584.1 - 4.8 6.7 10.5 9.1 5.8 2.6 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus BST2 PF16716.5 KII68584.1 - 6 7.5 11.0 37 5.0 3.6 2.9 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF1192 PF06698.11 KII68584.1 - 6.2 7.0 10.0 11 6.2 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) ZapB PF06005.12 KII68584.1 - 6.9 7.2 15.0 14 6.2 4.2 3.0 1 1 2 3 3 3 0 Cell division protein ZapB DUF641 PF04859.12 KII68584.1 - 7.2 7.0 10.5 12 6.3 3.4 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) PKcGMP_CC PF16808.5 KII68585.1 - 0.0011 18.8 0.9 0.0011 18.8 0.9 3.1 3 0 0 3 3 3 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Fib_alpha PF08702.10 KII68585.1 - 0.0012 19.1 9.6 0.0017 18.5 9.6 1.4 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Vir_act_alpha_C PF10400.9 KII68585.1 - 0.0019 18.9 1.0 0.0019 18.9 1.0 1.8 2 0 0 2 2 2 1 Virulence activator alpha C-term Lebercilin PF15619.6 KII68585.1 - 0.0026 17.4 8.0 0.0037 16.9 8.0 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease ERM PF00769.19 KII68585.1 - 0.0039 17.0 4.0 0.0049 16.7 4.0 1.0 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Bap31_Bap29_C PF18035.1 KII68585.1 - 0.0095 15.9 7.8 0.097 12.7 0.2 3.2 3 1 0 3 3 3 1 Bap31/Bap29 cytoplasmic coiled-coil domain GAS PF13851.6 KII68585.1 - 0.011 15.1 13.4 0.14 11.5 1.5 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 KII68585.1 - 0.024 15.1 5.5 0.033 14.6 5.5 1.2 1 0 0 1 1 1 0 Fez1 CSTF_C PF14304.6 KII68585.1 - 0.026 14.1 1.0 3.6 7.3 0.1 2.8 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal HIP1_clath_bdg PF16515.5 KII68585.1 - 0.055 14.1 5.9 0.62 10.7 1.5 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HMMR_N PF15905.5 KII68585.1 - 0.11 12.0 11.9 0.98 8.8 1.7 2.4 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal IFT20 PF14931.6 KII68585.1 - 0.11 12.6 8.2 0.49 10.6 7.5 1.9 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 Atg14 PF10186.9 KII68585.1 - 0.12 11.4 6.6 0.14 11.2 6.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF16 PF01519.16 KII68585.1 - 0.14 12.7 9.9 1.5 9.4 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF4140 PF13600.6 KII68585.1 - 0.16 12.4 4.9 1.8 9.1 0.7 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Csm1_N PF18504.1 KII68585.1 - 0.26 11.7 8.9 3.7 8.0 1.4 3.1 1 1 1 2 2 2 0 Csm1 N-terminal domain ABC_tran_CTD PF16326.5 KII68585.1 - 0.36 11.1 11.0 0.58 10.4 0.4 3.1 2 1 0 2 2 2 0 ABC transporter C-terminal domain PspA_IM30 PF04012.12 KII68585.1 - 0.51 9.9 8.4 4.7 6.7 0.3 2.0 1 1 1 2 2 2 0 PspA/IM30 family TMPIT PF07851.13 KII68585.1 - 0.65 9.2 5.3 0.77 8.9 5.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein BRE1 PF08647.11 KII68585.1 - 0.85 9.7 10.8 6.7 6.9 0.5 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DivIC PF04977.15 KII68585.1 - 0.88 9.4 9.3 0.15 11.8 1.2 2.6 1 1 2 3 3 3 0 Septum formation initiator DUF848 PF05852.11 KII68585.1 - 0.9 9.6 6.3 9.8 6.3 1.7 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DASH_Spc34 PF08657.10 KII68585.1 - 0.9 9.3 11.0 3.9 7.2 5.7 2.0 1 1 1 2 2 2 0 DASH complex subunit Spc34 Tropomyosin_1 PF12718.7 KII68585.1 - 1.3 9.1 10.6 4.1 7.5 1.4 2.2 1 1 1 2 2 2 0 Tropomyosin like DUF724 PF05266.14 KII68585.1 - 2.7 7.8 8.8 36 4.1 8.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) FAM76 PF16046.5 KII68585.1 - 9.3 5.5 8.4 24 4.2 8.3 1.6 1 1 0 1 1 1 0 FAM76 protein DUF1612 PF07756.12 KII68587.1 - 0.15 12.4 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) PRD PF00874.20 KII68590.1 - 0.021 15.1 1.9 0.11 12.9 0.2 2.1 1 1 0 2 2 2 0 PRD domain DUF1570 PF07607.11 KII68590.1 - 0.099 12.9 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1570) E6 PF00518.17 KII68591.1 - 0.052 14.0 0.1 0.063 13.7 0.1 1.3 1 0 0 1 1 1 0 Early Protein (E6) CNOT11 PF10155.9 KII68593.1 - 0.032 14.4 0.3 0.054 13.6 0.3 1.4 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 Guanylate_cyc PF00211.20 KII68595.1 - 0.12 12.0 0.3 0.2 11.3 0.0 1.4 2 0 0 2 2 2 0 Adenylate and Guanylate cyclase catalytic domain SNAP PF14938.6 KII68596.1 - 1.7e-06 27.7 0.3 2.2e-06 27.3 0.3 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP EF_TS PF00889.19 KII68597.1 - 0.00024 20.8 1.8 0.00024 20.8 1.8 1.7 2 0 0 2 2 2 1 Elongation factor TS DsrC PF04358.13 KII68597.1 - 0.0056 17.2 0.6 0.0091 16.5 0.4 1.4 1 1 0 1 1 1 1 DsrC like protein Phage_rep_O PF04492.13 KII68597.1 - 0.0069 16.9 0.8 0.1 13.2 0.0 2.2 1 1 1 2 2 2 1 Bacteriophage replication protein O DUF5644 PF18712.1 KII68597.1 - 0.021 14.8 0.5 0.028 14.4 0.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5644) DUF2114 PF09887.9 KII68597.1 - 0.036 12.6 0.1 0.041 12.4 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2114) SapB_1 PF05184.15 KII68597.1 - 0.068 13.2 4.2 0.072 13.1 0.1 2.9 2 1 2 4 4 4 0 Saposin-like type B, region 1 PIN_8 PF18476.1 KII68597.1 - 0.089 12.6 7.4 1 9.1 3.3 2.0 1 1 1 2 2 2 0 PIN like domain UBA_2 PF08587.11 KII68597.1 - 4.7 7.4 7.7 1.9 8.7 1.8 2.4 2 1 1 3 3 3 0 Ubiquitin associated domain (UBA) DDE_3 PF13358.6 KII68600.1 - 4.1e-20 72.0 0.0 5.6e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Imm-NTF2-2 PF15631.6 KII68600.1 - 0.0076 16.5 0.2 0.076 13.3 0.0 2.1 2 0 0 2 2 2 1 NTF2 fold immunity protein DUF4371 PF14291.6 KII68601.1 - 0.0004 20.1 0.0 0.00046 19.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DNase-RNase PF02577.14 KII68603.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Bifunctional nuclease Tetraspanin PF00335.20 KII68604.1 - 9.3e-14 51.7 16.6 1.2e-13 51.3 16.6 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF3810 PF12725.7 KII68604.1 - 0.064 12.6 7.5 0.087 12.1 7.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) GTA_holin_3TM PF11351.8 KII68604.1 - 0.084 13.4 0.1 0.16 12.5 0.1 1.4 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release DUF3938 PF13074.6 KII68604.1 - 0.47 10.7 7.2 0.33 11.2 5.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3938) zf-C2H2_4 PF13894.6 KII68605.1 - 3.8e-06 27.3 6.5 0.00024 21.7 0.1 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KII68605.1 - 4.9e-06 26.7 1.6 0.00098 19.5 0.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KII68605.1 - 0.00019 21.7 4.1 0.14 12.7 0.0 2.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 KII68605.1 - 0.00031 20.7 1.3 0.0019 18.1 0.1 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KII68605.1 - 0.00066 19.9 1.9 0.0079 16.5 0.1 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Sec23_Sec24 PF04810.15 KII68605.1 - 0.0019 18.2 5.7 0.037 14.1 2.4 2.5 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger zf-met PF12874.7 KII68605.1 - 0.0068 16.8 3.0 0.39 11.2 0.0 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 KII68605.1 - 0.017 15.2 1.1 1.7 8.8 0.2 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 KII68605.1 - 0.077 13.3 1.2 0.077 13.3 1.2 2.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF5343 PF17278.2 KII68606.1 - 0.0059 16.7 2.1 0.0098 16.0 1.4 1.7 1 1 1 2 2 2 1 Family of unknown function (DUF5343) DUF2778 PF10908.8 KII68606.1 - 0.036 14.4 0.5 0.14 12.5 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2778) TFIIIC_delta PF12657.7 KII68606.1 - 0.051 13.5 0.5 1.9 8.4 0.0 2.1 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term DASH_Dam1 PF08653.10 KII68606.1 - 0.1 12.4 0.9 1.1 9.1 0.1 2.7 1 1 1 2 2 2 0 DASH complex subunit Dam1 Wax2_C PF12076.8 KII68606.1 - 0.13 12.0 0.2 0.21 11.3 0.2 1.3 1 0 0 1 1 1 0 WAX2 C-terminal domain DDE_3 PF13358.6 KII68615.1 - 1.9e-11 43.9 0.0 2.5e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease CRIC_ras_sig PF10534.9 KII68615.1 - 0.044 14.0 0.0 0.095 12.9 0.0 1.6 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras DUF5506 PF17611.2 KII68616.1 - 0.31 10.9 3.3 0.15 12.0 0.3 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5506) Integrin_beta PF00362.18 KII68617.1 - 8.4e-13 48.5 0.0 1e-12 48.3 0.0 1.0 1 0 0 1 1 1 1 Integrin beta chain VWA domain CENP-B_dimeris PF09026.10 KII68619.1 - 0.064 13.6 4.1 0.098 13.1 4.1 1.5 1 1 0 1 1 1 0 Centromere protein B dimerisation domain zf-UBR PF02207.20 KII68620.1 - 7.2e-12 45.3 14.0 2.5e-11 43.6 14.0 2.0 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) rve PF00665.26 KII68623.1 - 1.5e-05 25.2 0.0 1.7e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 KII68625.1 - 2.4e-06 27.4 14.4 9.5e-05 22.3 2.1 2.2 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 KII68625.1 - 0.00065 19.3 13.6 0.009 15.7 2.2 2.2 1 1 1 2 2 2 2 GAG-polyprotein viral zinc-finger Peptidase_C39 PF03412.15 KII68625.1 - 0.0036 17.1 0.1 0.0046 16.8 0.1 1.1 1 0 0 1 1 1 1 Peptidase C39 family zf-CCHC_3 PF13917.6 KII68625.1 - 3.1 7.9 18.0 4.1 7.4 7.4 2.9 2 1 1 3 3 3 0 Zinc knuckle DUF3130 PF11328.8 KII68626.1 - 0.12 12.7 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3130 rve PF00665.26 KII68627.1 - 0.00075 19.7 0.0 0.0013 18.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII68627.1 - 0.033 14.0 0.0 0.059 13.2 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain DUF3293 PF11697.8 KII68627.1 - 0.14 12.7 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3293) Filo_VP35 PF02097.15 KII68628.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Filoviridae VP35 RVT_1 PF00078.27 KII68629.1 - 1.3e-21 77.1 0.0 1.5e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF815 PF05673.13 KII68629.1 - 0.04 13.1 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF1335 PF07056.11 KII68629.1 - 0.098 12.8 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) ADPrib_exo_Tox PF03496.14 KII68631.1 - 0.028 13.7 0.7 0.044 13.1 0.7 1.3 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme Spc7_N PF15402.6 KII68632.1 - 0.0069 14.7 0.0 0.0083 14.4 0.0 1.0 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 KH_1 PF00013.29 KII68634.1 - 1.5e-19 69.6 6.2 5.2e-08 32.6 0.0 6.4 6 0 0 6 6 6 5 KH domain DUF4974 PF16344.5 KII68634.1 - 0.044 13.8 0.2 0.044 13.8 0.2 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4974) Eno-Rase_NADH_b PF12242.8 KII68634.1 - 0.088 12.6 0.1 3 7.7 0.1 3.1 4 0 0 4 4 4 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF4164 PF13747.6 KII68634.1 - 0.089 13.1 0.1 0.56 10.5 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) DUF2096 PF09869.9 KII68634.1 - 0.39 10.8 4.0 2.2 8.3 0.2 3.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2096) BORCS8 PF10167.9 KII68634.1 - 0.62 10.0 4.3 5.4 7.0 0.5 2.8 1 1 0 2 2 2 0 BLOC-1-related complex sub-unit 8 Phage-tail_1 PF09097.10 KII68635.1 - 0.049 13.4 0.1 0.071 12.9 0.1 1.2 1 0 0 1 1 1 0 Baseplate structural protein, domain 1 zf-BED PF02892.15 KII68636.1 - 1.3e-06 28.3 0.4 3.1e-06 27.1 0.4 1.7 1 0 0 1 1 1 1 BED zinc finger RT_RNaseH PF17917.1 KII68637.1 - 2.6e-40 136.9 0.0 5.9e-40 135.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII68637.1 - 6e-36 122.5 0.0 1.5e-35 121.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII68637.1 - 1.9e-30 106.1 0.1 3.9e-30 105.0 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII68637.1 - 9.3e-27 93.6 0.0 3.3e-26 91.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII68637.1 - 2.4e-17 62.8 5.2 5.8e-17 61.6 2.5 2.8 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII68637.1 - 2.7e-06 27.8 0.0 6.5e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 KII68637.1 - 6.5e-06 26.0 0.5 1.4e-05 24.9 0.5 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII68637.1 - 2.4e-05 24.1 0.0 8.9e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.23 KII68637.1 - 0.00018 21.4 8.9 0.087 12.9 1.1 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-H2C2 PF09337.10 KII68637.1 - 0.0012 19.0 0.0 0.0084 16.3 0.0 2.5 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII68637.1 - 0.0028 17.4 0.0 0.008 15.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII68637.1 - 0.018 15.1 0.0 0.052 13.6 0.0 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Asp_protease_2 PF13650.6 KII68637.1 - 0.023 15.3 0.0 0.055 14.1 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII68637.1 - 0.079 13.3 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_2 PF13696.6 KII68637.1 - 0.24 11.3 11.8 1.6 8.6 4.6 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII68637.1 - 0.32 10.7 6.8 1.6 8.5 0.7 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 KII68637.1 - 0.35 10.7 13.7 0.25 11.2 2.4 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 KII68637.1 - 0.47 10.5 13.5 58 3.8 13.5 2.7 1 1 0 1 1 1 0 Zinc knuckle DUF5617 PF18493.1 KII68638.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) adh_short PF00106.25 KII68640.1 - 5.4e-42 143.5 0.3 1.1e-41 142.5 0.3 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII68640.1 - 4.2e-24 85.4 0.5 7e-24 84.7 0.5 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII68640.1 - 9.2e-12 45.2 0.0 1.3e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 KII68640.1 - 0.00044 19.6 0.0 0.001 18.4 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 KII68640.1 - 0.0017 17.9 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 KII68640.1 - 0.021 14.7 0.1 0.033 14.1 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 KII68640.1 - 0.041 14.3 0.3 0.076 13.5 0.3 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Lon_C PF05362.13 KII68640.1 - 0.043 13.3 0.1 0.072 12.6 0.1 1.3 1 0 0 1 1 1 0 Lon protease (S16) C-terminal proteolytic domain Eno-Rase_NADH_b PF12242.8 KII68640.1 - 0.047 13.4 0.5 0.047 13.4 0.5 2.2 2 1 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Pyr_redox_3 PF13738.6 KII68640.1 - 0.064 12.5 0.1 0.097 11.9 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GRDA PF04723.14 KII68640.1 - 0.098 12.4 1.0 0.54 10.0 0.2 2.1 2 0 0 2 2 2 0 Glycine reductase complex selenoprotein A DUF4491 PF14898.6 KII68640.1 - 0.71 10.4 4.2 4.4 7.8 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) Ribosomal_S30AE PF02482.19 KII68642.1 - 0.04 14.7 1.4 0.098 13.4 0.1 2.1 2 1 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein Ribosomal_L6 PF00347.23 KII68643.1 - 3e-17 63.1 3.7 2.3e-11 44.2 0.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Sec10 PF07393.11 KII68645.1 - 2.4e-11 42.8 0.6 2.9e-11 42.6 0.6 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF1682 PF07946.14 KII68646.1 - 1.1e-06 28.1 24.5 0.0017 17.6 24.5 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1682) E1_DerP2_DerF2 PF02221.15 KII68647.1 - 0.00017 22.0 0.0 0.00021 21.7 0.0 1.1 1 0 0 1 1 1 1 ML domain Peptidase_M28 PF04389.17 KII68650.1 - 1.2e-40 139.4 0.0 1.5e-40 139.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 PEX-2N PF09263.10 KII68650.1 - 0.16 12.3 0.0 8.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal FadA PF09403.10 KII68651.1 - 0.15 12.5 2.6 0.26 11.8 2.6 1.3 1 0 0 1 1 1 0 Adhesion protein FadA Bmt2 PF11968.8 KII68652.1 - 0.071 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 DUF1198 PF06711.11 KII68654.1 - 0.036 14.1 0.0 0.058 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) Glyco_transf_25 PF01755.17 KII68655.1 - 1.2e-22 80.8 0.4 5.2e-22 78.7 0.4 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Caudo_TAP PF02413.17 KII68656.1 - 1.7e-21 76.8 0.5 2e-21 76.5 0.5 1.1 1 0 0 1 1 1 1 Caudovirales tail fibre assembly protein, lambda gpK DUF5347 PF17282.2 KII68656.1 - 0.12 12.7 0.1 0.18 12.1 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5347) gp37_C PF12604.8 KII68657.1 - 0.00075 19.2 1.4 0.0011 18.6 1.4 1.3 1 0 0 1 1 1 1 Tail fibre protein gp37 C terminal EKR PF10371.9 KII68659.1 - 0.19 11.5 0.0 31 4.4 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function Lgl_C PF08596.10 KII68660.1 - 0.2 10.3 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal RT_RNaseH_2 PF17919.1 KII68661.1 - 4.6e-21 74.7 0.0 1.3e-20 73.3 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII68661.1 - 1.6e-12 47.4 0.5 2.6e-12 46.8 0.5 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII68661.1 - 3.1e-09 37.1 0.0 8.6e-09 35.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase YbjN PF10722.9 KII68661.1 - 0.039 14.0 0.0 2.6 8.1 0.0 2.1 2 0 0 2 2 2 0 Putative bacterial sensory transduction regulator DUF4947 PF16305.5 KII68661.1 - 0.06 13.4 0.0 0.11 12.5 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4947) zf-CCHC PF00098.23 KII68662.1 - 0.00013 21.9 3.4 0.00013 21.9 3.4 1.8 2 0 0 2 2 2 1 Zinc knuckle Myb_DNA-bind_5 PF13873.6 KII68662.1 - 0.013 15.6 0.3 0.02 15.0 0.3 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain AKNA PF12443.8 KII68662.1 - 0.027 15.1 1.1 0.13 13.0 0.2 2.2 2 0 0 2 2 2 0 AT-hook-containing transcription factor CBP4 PF07960.11 KII68662.1 - 0.085 12.7 0.4 0.099 12.5 0.4 1.2 1 0 0 1 1 1 0 CBP4 HalX PF08663.10 KII68662.1 - 0.098 13.0 0.6 0.19 12.1 0.6 1.4 1 0 0 1 1 1 0 HalX domain Csm1_N PF18504.1 KII68662.1 - 0.11 12.9 0.9 0.2 12.0 0.9 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain TcpS PF17456.2 KII68662.1 - 0.12 12.4 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S TSC22 PF01166.18 KII68662.1 - 0.12 12.7 0.4 0.12 12.7 0.4 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family FlxA PF14282.6 KII68662.1 - 0.2 11.7 2.8 0.13 12.3 1.0 1.5 2 0 0 2 2 2 0 FlxA-like protein zf-CCHC_2 PF13696.6 KII68662.1 - 1.1 9.2 4.9 1.8 8.5 4.9 1.4 1 0 0 1 1 1 0 Zinc knuckle MSP7_C PF12948.7 KII68663.1 - 0.011 16.4 0.2 0.15 12.8 0.0 2.3 2 0 0 2 2 2 0 MSP7-like protein C-terminal domain Prp18 PF02840.15 KII68667.1 - 0.58 10.2 4.3 2.4 8.2 0.2 2.7 3 0 0 3 3 3 0 Prp18 domain Ribonuc_2-5A PF06479.12 KII68668.1 - 0.13 12.5 1.5 0.7 10.1 0.0 2.7 2 0 0 2 2 2 0 Ribonuclease 2-5A PI-PLC-X PF00388.19 KII68674.1 - 0.17 11.5 2.1 0.24 11.0 0.2 2.0 2 0 0 2 2 2 0 Phosphatidylinositol-specific phospholipase C, X domain DUF4996 PF16387.5 KII68675.1 - 0.086 13.3 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF2096 PF09869.9 KII68676.1 - 0.12 12.4 0.0 0.36 10.9 0.0 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) Mcl1_mid PF12341.8 KII68678.1 - 1.6e-12 47.4 0.1 2e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region NFACT-R_1 PF05670.13 KII68681.1 - 5.2e-30 104.3 0.0 5.2e-30 104.3 0.0 2.9 3 0 0 3 3 3 1 NFACT protein RNA binding domain NFACT-C PF11923.8 KII68681.1 - 2.5e-25 88.4 0.0 2.5e-25 88.4 0.0 3.6 3 1 0 3 3 3 1 NFACT protein C-terminal domain NFACT-R_2 PF18297.1 KII68681.1 - 0.0014 18.8 0.0 0.0014 18.8 0.0 3.5 4 1 0 4 4 4 1 NFACT protein RNA binding domain Ig_2 PF13895.6 KII68682.1 - 0.021 15.1 0.1 0.87 10.0 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 KII68682.1 - 0.051 13.8 0.9 0.22 11.7 0.1 2.5 2 1 0 2 2 2 0 Immunoglobulin V-set domain FcoT PF10862.8 KII68682.1 - 0.064 12.8 0.1 0.17 11.5 0.1 1.8 1 0 0 1 1 1 0 FcoT-like thioesterase domain Izumo-Ig PF16706.5 KII68682.1 - 0.064 13.3 0.2 0.49 10.5 0.0 2.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain fn3 PF00041.21 KII68682.1 - 0.094 13.1 0.5 1.8 9.0 0.1 2.6 2 0 0 2 2 2 0 Fibronectin type III domain Noc2 PF03715.13 KII68683.1 - 1.9e-47 162.0 5.3 1.9e-47 162.0 5.3 1.7 2 0 0 2 2 2 1 Noc2p family Grp7_allergen PF16984.5 KII68683.1 - 0.19 11.7 1.2 0.48 10.4 0.1 2.0 2 0 0 2 2 2 0 Group 7 allergen Isochorismatase PF00857.20 KII68685.1 - 1.3e-14 54.8 0.3 1.4e-14 54.7 0.3 1.1 1 0 0 1 1 1 1 Isochorismatase family RRM_1 PF00076.22 KII68686.1 - 7.6e-14 51.3 0.0 1.2e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 KII68686.1 - 3.1e-06 27.6 1.7 3.1e-06 27.6 1.7 2.4 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 KII68686.1 - 0.16 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Myb_DNA-binding PF00249.31 KII68688.1 - 1.2e-14 54.2 1.4 1.3e-06 28.5 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII68688.1 - 7.3e-11 42.2 0.2 0.00016 21.8 0.0 2.7 2 1 0 2 2 2 2 Myb-like DNA-binding domain DDE_3 PF13358.6 KII68689.1 - 2.3e-09 37.2 0.3 3.1e-09 36.7 0.3 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Myb_DNA-binding PF00249.31 KII68690.1 - 2.4e-11 43.6 2.8 2e-06 27.9 0.2 3.8 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII68690.1 - 6.4e-08 32.7 3.4 4e-06 27.0 0.2 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF445 PF04286.12 KII68690.1 - 0.016 15.0 0.7 0.019 14.8 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) FAM193_C PF15914.5 KII68690.1 - 0.022 14.5 0.1 0.073 12.8 0.1 1.8 1 0 0 1 1 1 0 FAM193 family C-terminal SANT_DAMP1_like PF16282.5 KII68690.1 - 0.11 12.7 2.4 1 9.6 0.0 3.1 2 1 1 4 4 4 0 SANT/Myb-like domain of DAMP1 AAA_5 PF07728.14 KII68692.1 - 4.5e-108 357.1 0.0 6.9e-24 84.4 0.0 9.0 9 0 0 9 9 8 8 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KII68692.1 - 1.3e-34 118.9 0.0 1.2e-13 51.1 0.0 6.7 6 0 0 6 6 6 3 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KII68692.1 - 8e-17 61.3 0.2 0.0068 15.9 0.0 6.4 6 0 0 6 6 6 4 P-loop containing dynein motor region AAA PF00004.29 KII68692.1 - 9.4e-17 61.7 1.7 0.02 15.3 0.0 7.0 7 0 0 7 7 6 4 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII68692.1 - 1.8e-16 61.0 1.4 0.0034 17.8 0.0 6.1 5 1 0 6 6 5 4 AAA ATPase domain Dynein_heavy PF03028.15 KII68692.1 - 1.2e-13 51.2 0.0 0.023 14.8 0.0 6.2 6 0 0 6 6 5 3 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 KII68692.1 - 3.4e-13 50.1 2.1 0.00078 19.7 0.0 6.4 6 1 0 6 6 5 3 AAA domain AAA_14 PF13173.6 KII68692.1 - 1.4e-11 44.6 3.4 0.023 14.7 0.0 7.6 8 1 1 9 9 7 3 AAA domain ABC_tran PF00005.27 KII68692.1 - 1.5e-11 44.9 1.0 0.0042 17.6 0.0 7.3 7 0 0 7 7 6 2 ABC transporter AAA_6 PF12774.7 KII68692.1 - 6.3e-11 41.8 1.2 0.83 8.6 0.0 7.4 5 2 1 6 6 6 3 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 KII68692.1 - 1.5e-10 41.1 0.0 0.062 13.3 0.0 5.3 4 0 0 4 4 4 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KII68692.1 - 2.7e-10 40.2 0.0 0.57 9.9 0.0 5.2 5 0 0 5 5 4 3 Sigma-54 interaction domain AAA_lid_7 PF17867.1 KII68692.1 - 5e-09 36.3 0.3 5.5e-08 33.0 0.5 2.8 2 0 0 2 2 1 1 Midasin AAA lid domain VWA_2 PF13519.6 KII68692.1 - 1.5e-08 35.2 0.2 1.1e-06 29.2 0.0 3.7 2 0 0 2 2 2 1 von Willebrand factor type A domain AAA_18 PF13238.6 KII68692.1 - 3.1e-07 31.0 0.3 1.3 9.6 0.0 6.1 5 0 0 5 5 4 1 AAA domain Sigma54_activ_2 PF14532.6 KII68692.1 - 2.7e-06 27.6 0.1 0.84 9.7 0.0 5.1 5 0 0 5 5 4 1 Sigma-54 interaction domain AAA_30 PF13604.6 KII68692.1 - 2.9e-06 27.1 0.0 0.22 11.2 0.0 4.6 5 0 0 5 5 5 1 AAA domain MCM PF00493.23 KII68692.1 - 4.1e-06 26.1 0.0 0.016 14.3 0.0 3.9 3 0 0 3 3 3 1 MCM P-loop domain Mg_chelatase PF01078.21 KII68692.1 - 5.9e-06 25.8 0.0 1.7 8.0 0.0 5.2 5 1 0 5 5 5 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 KII68692.1 - 8.1e-06 25.9 0.4 0.99 9.3 0.0 4.7 4 0 0 4 4 4 2 NACHT domain Rad17 PF03215.15 KII68692.1 - 1.6e-05 25.0 8.2 0.19 11.7 0.1 5.3 5 0 0 5 5 4 2 Rad17 P-loop domain Roc PF08477.13 KII68692.1 - 2.8e-05 24.3 0.2 5.4 7.3 0.0 4.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 KII68692.1 - 3.3e-05 24.2 2.6 9 6.7 0.0 6.5 6 0 0 6 6 5 0 RNA helicase AAA_29 PF13555.6 KII68692.1 - 5.3e-05 22.9 1.4 6 6.7 0.0 5.0 5 0 0 5 5 4 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 KII68692.1 - 5.3e-05 23.0 0.5 0.76 9.5 0.0 4.5 5 0 0 5 5 4 2 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.12 KII68692.1 - 7.4e-05 22.5 1.6 3.3 7.4 0.0 5.6 6 0 0 6 6 6 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 KII68692.1 - 0.00012 21.8 0.4 4 7.0 0.0 4.1 4 0 0 4 4 4 1 AAA domain T2SSE PF00437.20 KII68692.1 - 0.00013 21.2 1.0 26 3.8 0.0 5.6 5 0 0 5 5 5 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 KII68692.1 - 0.00015 21.1 0.0 2.5 7.3 0.0 4.7 5 0 0 5 5 5 1 Zeta toxin AAA_33 PF13671.6 KII68692.1 - 0.00025 21.2 0.0 2.8 8.1 0.0 4.6 4 0 0 4 4 4 1 AAA domain VWA PF00092.28 KII68692.1 - 0.00041 20.6 1.1 0.00094 19.5 0.1 2.2 2 0 0 2 2 1 1 von Willebrand factor type A domain SRP54 PF00448.22 KII68692.1 - 0.0028 17.3 0.0 9.9 5.7 0.0 3.5 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain IstB_IS21 PF01695.17 KII68692.1 - 0.0086 15.8 0.2 21 4.8 0.0 5.0 5 0 0 5 5 5 0 IstB-like ATP binding protein DUF815 PF05673.13 KII68692.1 - 0.012 14.8 0.1 0.56 9.3 0.0 3.4 4 0 0 4 4 3 0 Protein of unknown function (DUF815) AAA_19 PF13245.6 KII68692.1 - 0.012 16.0 0.0 13 6.1 0.0 3.8 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 KII68692.1 - 0.014 15.3 2.2 1.3 8.9 0.0 4.7 6 0 0 6 6 4 0 RsgA GTPase AAA_28 PF13521.6 KII68692.1 - 0.016 15.4 6.3 23 5.2 0.0 5.2 5 0 0 5 5 5 0 AAA domain TniB PF05621.11 KII68692.1 - 0.024 14.0 0.0 11 5.4 0.0 3.8 3 0 0 3 3 3 0 Bacterial TniB protein MMR_HSR1 PF01926.23 KII68692.1 - 0.056 13.5 0.6 81 3.3 0.0 4.4 4 0 0 4 4 3 0 50S ribosome-binding GTPase CPT PF07931.12 KII68692.1 - 0.058 13.2 0.1 42 3.9 0.0 4.1 3 1 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein TIP49 PF06068.13 KII68692.1 - 0.06 12.6 0.1 18 4.4 0.0 3.7 3 0 0 3 3 3 0 TIP49 P-loop domain PriCT_1 PF08708.11 KII68692.1 - 0.064 13.0 0.0 0.27 11.0 0.0 2.2 1 0 0 1 1 1 0 Primase C terminal 1 (PriCT-1) SRTM1 PF15872.5 KII68694.1 - 0.064 13.4 1.4 0.092 12.9 1.4 1.3 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 Sortilin-Vps10 PF15902.5 KII68695.1 - 5.1e-06 25.5 0.2 8.7e-06 24.8 0.2 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII68695.1 - 0.0063 16.9 0.1 0.015 15.7 0.0 1.6 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal DDE_3 PF13358.6 KII68698.1 - 2.5e-26 92.2 0.0 3e-26 91.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Colicin_Pyocin PF01320.18 KII68698.1 - 0.017 15.2 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein Rad51 PF08423.11 KII68699.1 - 1.2e-06 28.0 0.0 1.4e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Rad51 PX PF00787.24 KII68700.1 - 0.00054 19.9 0.0 0.00083 19.3 0.0 1.3 1 1 0 1 1 1 1 PX domain CsgA PF17334.2 KII68700.1 - 0.035 14.8 0.1 0.96 10.2 0.0 2.1 2 0 0 2 2 2 0 Minor curli fiber component A Vps5 PF09325.10 KII68701.1 - 8.7e-08 32.0 1.9 1.2e-07 31.5 1.5 1.4 1 1 0 1 1 1 1 Vps5 C terminal like BAR_3_WASP_bdg PF10456.9 KII68701.1 - 5.1e-05 22.9 1.4 6.3e-05 22.5 1.4 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein DUF4680 PF15730.5 KII68701.1 - 0.018 15.4 0.2 0.069 13.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) ELMO_CED12 PF04727.13 KII68702.1 - 2.4e-13 50.6 0.0 4.3e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family zf-C3H2C3 PF17122.5 KII68703.1 - 2.6e-05 24.2 8.5 8.1e-05 22.6 8.5 1.9 1 1 0 1 1 1 1 Zinc-finger HAP1_N PF04849.13 KII68703.1 - 0.0047 16.2 0.8 0.0083 15.4 0.8 1.3 1 0 0 1 1 1 1 HAP1 N-terminal conserved region zf-ANAPC11 PF12861.7 KII68703.1 - 0.018 15.1 2.8 0.026 14.6 2.8 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 KII68703.1 - 0.043 13.8 7.8 0.13 12.3 7.8 1.9 1 1 0 1 1 1 0 RING-type zinc-finger BEX PF04538.12 KII68703.1 - 0.1 13.2 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Brain expressed X-linked like family PI3K_P85_iSH2 PF16454.5 KII68703.1 - 0.11 12.1 6.8 0.27 10.8 6.8 1.8 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain zf-C3HC4_2 PF13923.6 KII68703.1 - 1.3 8.9 14.6 30 4.6 14.9 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 KII68703.1 - 2.5 8.1 12.5 23 5.0 12.7 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 KII68703.1 - 4.1 7.8 14.2 16 5.9 14.2 2.0 1 1 1 2 2 2 0 Ring finger domain Clathrin PF00637.20 KII68704.1 - 1.4e-16 60.6 14.4 8.2e-11 42.0 1.9 3.0 1 1 1 3 3 3 2 Region in Clathrin and VPS DUF5578 PF17741.1 KII68704.1 - 0.068 12.6 0.5 0.14 11.6 0.2 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5578) VHP PF02209.19 KII68706.1 - 1.7e-09 37.6 7.7 1.7e-09 37.6 7.7 3.4 3 0 0 3 3 3 1 Villin headpiece domain Gelsolin PF00626.22 KII68706.1 - 0.0024 17.7 3.8 0.95 9.4 0.0 3.5 3 1 0 3 3 3 2 Gelsolin repeat Phi-29_GP4 PF05464.11 KII68706.1 - 0.054 13.8 0.4 0.14 12.4 0.4 1.7 1 0 0 1 1 1 0 Phi-29-like late genes activator (early protein GP4) SKIP_SNW PF02731.15 KII68707.1 - 3.7e-57 192.5 0.9 3.7e-57 192.5 0.9 2.6 3 0 0 3 3 3 2 SKIP/SNW domain HSP70 PF00012.20 KII68707.1 - 5.5 5.0 7.8 0.77 7.9 4.1 1.4 2 0 0 2 2 2 0 Hsp70 protein FTO_CTD PF12934.7 KII68708.1 - 0.0027 17.5 0.3 0.0032 17.2 0.3 1.1 1 0 0 1 1 1 1 FTO C-terminal domain Peptidase_M75 PF09375.10 KII68708.1 - 0.032 13.7 0.3 0.036 13.5 0.3 1.1 1 0 0 1 1 1 0 Imelysin SRA1 PF07304.11 KII68708.1 - 0.071 12.9 0.2 0.084 12.7 0.2 1.1 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) Iron_permease PF04120.12 KII68708.1 - 0.34 10.7 3.2 0.42 10.4 3.2 1.1 1 0 0 1 1 1 0 Low affinity iron permease DDE_3 PF13358.6 KII68709.1 - 1e-12 48.0 0.0 1.4e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII68709.1 - 0.0041 16.9 0.0 0.022 14.6 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain DUF1323 PF07037.11 KII68709.1 - 0.0077 16.6 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_17 PF12728.7 KII68709.1 - 0.059 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain EGF_2 PF07974.13 KII68711.1 - 1.4e-07 31.7 35.5 6.4e-06 26.4 17.3 2.8 2 0 0 2 2 2 2 EGF-like domain I-EGF_1 PF18372.1 KII68711.1 - 0.00072 19.6 12.0 0.00072 19.6 12.0 3.5 2 1 0 2 2 2 1 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 KII68711.1 - 0.01 15.9 23.5 0.13 12.4 10.3 2.7 2 0 0 2 2 2 0 Tenascin EGF domain Integrin_beta PF00362.18 KII68712.1 - 1.5e-08 34.6 0.3 9.5e-05 22.2 0.0 2.1 1 1 1 2 2 2 2 Integrin beta chain VWA domain VWA_2 PF13519.6 KII68712.1 - 0.0012 19.4 0.0 0.0038 17.9 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain BAR PF03114.18 KII68713.1 - 9.1e-08 32.0 0.0 1e-07 31.8 0.0 1.0 1 0 0 1 1 1 1 BAR domain TTRAP PF14203.6 KII68713.1 - 0.015 15.2 0.5 0.034 14.1 0.0 1.8 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein PRANC PF09372.10 KII68713.1 - 0.039 14.3 2.8 4.3 7.7 0.2 2.2 1 1 1 2 2 2 0 PRANC domain RVT_1 PF00078.27 KII68714.1 - 3.7e-34 118.2 0.1 2.4e-33 115.5 0.0 2.3 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII68714.1 - 1.2e-09 38.6 0.1 2.7e-09 37.5 0.1 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII68714.1 - 5.6e-07 30.1 0.1 1.4e-06 28.8 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII68714.1 - 0.00011 22.5 0.0 0.00029 21.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 KII68714.1 - 0.00025 21.0 1.5 0.00055 19.9 1.5 1.6 1 0 0 1 1 1 1 Zinc knuckle Asp_protease PF09668.10 KII68714.1 - 0.0014 18.4 0.0 0.003 17.3 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A3 PF02160.15 KII68714.1 - 0.0035 16.9 1.0 0.0035 16.9 1.0 1.8 2 0 0 2 2 2 1 Cauliflower mosaic virus peptidase (A3) DUF4094 PF13334.6 KII68714.1 - 0.0098 16.3 1.7 0.024 15.0 1.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4094) Spuma_A9PTase PF03539.14 KII68714.1 - 0.034 14.3 0.0 0.091 12.9 0.0 1.8 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) DUF4509 PF14970.6 KII68714.1 - 1.2 9.1 6.4 0.59 10.0 3.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4509) DDE_3 PF13358.6 KII68715.1 - 3.3e-18 65.8 0.3 4e-18 65.6 0.3 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RapH_N PF18801.1 KII68715.1 - 0.026 14.6 1.4 0.72 10.0 0.1 2.5 2 1 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal ITAM_Cys-rich PF10538.9 KII68715.1 - 0.044 13.6 0.3 0.078 12.8 0.3 1.4 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif Adap_comp_sub PF00928.21 KII68715.1 - 0.055 12.8 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 Adaptor complexes medium subunit family Vac14_Fab1_bd PF12755.7 KII68716.1 - 1.3e-05 25.6 0.5 0.00012 22.6 0.1 2.1 2 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region DDE_Tnp_IS1595 PF12762.7 KII68717.1 - 2.2e-06 27.7 0.0 2.5e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Diphthamide_syn PF01866.17 KII68718.1 - 3.8e-45 154.6 6.1 4.6e-29 101.8 2.8 2.2 1 1 1 2 2 2 2 Putative diphthamide synthesis protein DDE_3 PF13358.6 KII68719.1 - 1.1e-17 64.1 0.1 3.1e-17 62.7 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII68719.1 - 8.3e-07 28.6 0.0 0.00012 21.8 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 KII68719.1 - 2.2e-05 25.0 0.0 0.00057 20.5 0.0 2.3 1 1 1 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 KII68719.1 - 0.0029 17.2 0.1 0.068 12.8 0.0 2.4 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_ABP1_N PF18107.1 KII68719.1 - 0.021 14.6 0.9 1.5 8.6 0.0 3.3 3 0 0 3 3 3 0 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc3_2 PF01498.18 KII68719.1 - 0.024 14.9 0.0 0.071 13.4 0.0 1.9 1 0 0 1 1 1 0 Transposase Sigma70_r4 PF04545.16 KII68719.1 - 0.028 13.9 0.0 0.09 12.3 0.0 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_3 PF01381.22 KII68719.1 - 0.037 14.1 0.1 12 6.0 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix HTH_28 PF13518.6 KII68719.1 - 0.064 13.4 0.0 0.48 10.6 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_29 PF13551.6 KII68719.1 - 0.12 12.4 0.0 0.32 11.1 0.0 1.7 2 0 0 2 2 2 0 Winged helix-turn helix HTH_38 PF13936.6 KII68719.1 - 0.13 12.0 1.3 4.7 7.1 0.0 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain Mito_carr PF00153.27 KII68720.1 - 0.002 18.0 0.1 0.0086 16.0 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial carrier protein Peptidase_M24 PF00557.24 KII68723.1 - 1.7e-50 171.6 0.1 2e-50 171.4 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 ATP-cone PF03477.16 KII68723.1 - 1.5e-05 25.5 0.1 0.00049 20.6 0.1 2.3 2 0 0 2 2 2 1 ATP cone domain Ribosomal_S26e PF01283.19 KII68724.1 - 5.6e-44 149.0 4.7 6.5e-44 148.8 4.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4 PF00037.27 KII68724.1 - 0.089 12.6 3.2 0.14 12.1 1.1 2.0 2 0 0 2 2 2 0 4Fe-4S binding domain zf-C2H2_11 PF16622.5 KII68724.1 - 0.22 11.3 0.2 0.22 11.3 0.2 2.1 2 1 0 2 2 2 0 zinc-finger C2H2-type THOC7 PF05615.13 KII68725.1 - 1.3e-17 64.3 10.7 1.1e-16 61.3 4.1 2.1 1 1 1 2 2 2 2 Tho complex subunit 7 FemAB PF02388.16 KII68725.1 - 0.0084 15.0 4.5 0.0092 14.9 4.5 1.1 1 0 0 1 1 1 1 FemAB family DUF3086 PF11285.8 KII68725.1 - 0.016 14.3 0.8 0.026 13.6 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) Effector_1 PF04518.12 KII68725.1 - 0.026 13.7 0.7 0.041 13.0 0.6 1.4 1 1 0 1 1 1 0 Effector from type III secretion system DUF1664 PF07889.12 KII68725.1 - 0.084 12.9 2.8 0.61 10.1 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CLZ PF16526.5 KII68725.1 - 0.14 12.5 3.6 0.19 12.1 0.2 2.9 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Mto2_bdg PF12808.7 KII68725.1 - 2.7 8.4 8.7 0.54 10.6 0.3 2.9 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Pyr_redox_dim PF02852.22 KII68726.1 - 5.6e-23 81.3 0.0 8.6e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 KII68726.1 - 7.4e-09 35.2 0.0 1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase BOP1NT PF08145.12 KII68727.1 - 6.9e-06 26.2 2.9 1.2e-05 25.4 2.9 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 KII68727.1 - 0.00018 22.2 0.1 0.0012 19.6 0.1 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat BOP1NT PF08145.12 KII68728.1 - 2.3e-19 70.3 0.0 2.6e-19 70.1 0.0 1.0 1 0 0 1 1 1 1 BOP1NT (NUC169) domain ANAPC4_WD40 PF12894.7 KII68730.1 - 0.02 15.1 0.0 0.034 14.4 0.0 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain F-actin_cap_A PF01267.17 KII68731.1 - 1.4e-64 218.1 0.6 1.5e-64 218.0 0.6 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Rox3 PF08633.10 KII68731.1 - 0.087 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Rox3 mediator complex subunit Diphthami_syn_2 PF01902.17 KII68732.1 - 6e-13 48.8 0.0 6.8e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Diphthamide synthase Diphthami_syn_2 PF01902.17 KII68733.1 - 5.8e-07 29.2 0.1 1.5e-06 27.9 0.1 1.6 1 1 0 1 1 1 1 Diphthamide synthase QueC PF06508.13 KII68733.1 - 0.076 12.5 0.0 0.13 11.7 0.0 1.5 1 1 0 1 1 1 0 Queuosine biosynthesis protein QueC DGF-1_4 PF11024.8 KII68736.1 - 0.089 13.6 2.1 4.5 8.2 0.0 2.2 1 1 1 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 G6PD_C PF02781.16 KII68737.1 - 3.9e-37 128.0 0.0 1.1e-36 126.5 0.0 1.7 1 1 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain SRP54 PF00448.22 KII68739.1 - 3.3e-77 258.6 0.2 6.1e-77 257.7 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 KII68739.1 - 4.1e-26 91.5 0.4 4.1e-26 91.5 0.4 2.7 2 0 0 2 2 2 1 Signal peptide binding domain cobW PF02492.19 KII68739.1 - 4.7e-07 29.6 0.8 9.2e-06 25.4 0.8 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 KII68739.1 - 9.6e-07 29.0 0.0 3.6e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 KII68739.1 - 1.8e-05 24.8 0.0 7.9e-05 22.7 0.0 2.0 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.6 KII68739.1 - 7.3e-05 23.2 0.0 0.00018 21.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII68739.1 - 0.00027 21.4 0.0 0.00077 19.9 0.0 1.9 2 1 0 2 2 1 1 AAA ATPase domain CLP1_P PF16575.5 KII68739.1 - 0.00029 20.7 0.5 0.25 11.1 0.1 2.5 2 0 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 KII68739.1 - 0.0011 18.7 0.0 0.0026 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KII68739.1 - 0.0014 18.0 0.0 0.0044 16.3 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin SRPRB PF09439.10 KII68739.1 - 0.0014 18.1 1.7 0.47 9.9 0.8 2.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 KII68739.1 - 0.0017 18.6 0.0 0.0053 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 KII68739.1 - 0.0044 16.8 0.2 0.015 15.1 0.1 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 KII68739.1 - 0.0049 16.9 0.3 0.036 14.1 0.3 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase APS_kinase PF01583.20 KII68739.1 - 0.0055 16.6 0.0 0.018 15.0 0.0 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase MobB PF03205.14 KII68739.1 - 0.0077 16.1 0.1 0.021 14.7 0.0 1.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B DUF2209 PF09974.9 KII68739.1 - 0.0091 16.3 0.3 0.0091 16.3 0.3 1.8 2 0 0 2 2 1 1 Uncharacterized protein conserved in archaea (DUF2209) PduV-EutP PF10662.9 KII68739.1 - 0.018 14.8 0.3 2.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_31 PF13614.6 KII68739.1 - 0.022 14.7 0.1 0.55 10.1 0.0 2.5 1 1 1 2 2 2 0 AAA domain ResIII PF04851.15 KII68739.1 - 0.028 14.4 0.3 0.33 10.9 0.3 2.2 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_28 PF13521.6 KII68739.1 - 0.031 14.5 0.0 0.061 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 KII68739.1 - 0.034 13.8 0.0 0.096 12.4 0.0 1.8 1 0 0 1 1 1 0 Thymidylate kinase AAA PF00004.29 KII68739.1 - 0.04 14.3 0.1 0.27 11.7 0.1 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 KII68739.1 - 0.078 11.9 0.3 0.42 9.6 0.3 2.1 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB 6PF2K PF01591.18 KII68739.1 - 0.093 12.0 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_8 PF12780.7 KII68739.1 - 0.097 12.0 0.1 0.53 9.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 NTPase_1 PF03266.15 KII68739.1 - 0.1 12.5 1.3 1.3 8.9 1.3 2.3 1 1 0 1 1 1 0 NTPase Serpin PF00079.20 KII68741.1 - 1.4e-40 139.8 0.0 1.6e-40 139.6 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII68742.1 - 2e-43 149.1 0.5 5.2e-40 137.9 0.1 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) Serpin PF00079.20 KII68743.1 - 1.5e-21 77.1 1.6 1.6e-21 77.0 1.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-UBR PF02207.20 KII68747.1 - 3.2e-11 43.2 13.2 3.2e-11 43.2 13.2 1.8 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-UBR PF02207.20 KII68748.1 - 2.5e-11 43.6 15.8 5.8e-11 42.4 15.8 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DDE_Tnp_IS1595 PF12762.7 KII68750.1 - 4.2e-17 62.6 0.0 7.1e-17 61.8 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain rve PF00665.26 KII68752.1 - 2.4e-16 60.0 0.0 3.8e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII68752.1 - 1.6e-05 24.6 0.1 5e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 KII68752.1 - 4.9e-05 23.4 0.0 0.00011 22.2 0.0 1.7 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain UN_NPL4 PF11543.8 KII68752.1 - 0.071 13.6 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 zf-U11-48K PF05253.12 KII68752.1 - 0.33 10.9 2.4 9.8 6.2 0.2 2.6 2 0 0 2 2 2 0 U11-48K-like CHHC zinc finger Med26 PF08711.11 KII68753.1 - 5.1e-11 42.4 1.0 9.3e-11 41.6 1.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain PDZ_2 PF13180.6 KII68756.1 - 0.022 15.1 0.2 0.049 14.0 0.2 1.5 1 0 0 1 1 1 0 PDZ domain TRAP-gamma PF07074.12 KII68756.1 - 1.9 8.0 4.1 20 4.7 0.0 2.2 2 0 0 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Homeodomain PF00046.29 KII68757.1 - 2.3e-14 53.0 6.9 5.4e-13 48.6 4.6 2.2 2 0 0 2 2 2 2 Homeodomain Homeobox_KN PF05920.11 KII68757.1 - 0.022 14.6 2.8 0.074 13.0 2.1 2.1 2 0 0 2 2 2 0 Homeobox KN domain Homeodomain PF00046.29 KII68758.1 - 4.4e-17 61.7 6.9 5.2e-16 58.2 4.4 2.4 2 0 0 2 2 2 1 Homeodomain Homez PF11569.8 KII68758.1 - 0.013 14.9 0.9 2.7 7.5 0.1 2.4 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 KII68758.1 - 0.02 14.8 1.5 0.043 13.7 0.2 2.1 2 0 0 2 2 2 0 Homeobox KN domain Pribosyl_synth PF14572.6 KII68759.1 - 2.6e-31 109.1 2.3 3.1e-31 108.8 2.3 1.1 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 KII68759.1 - 3.1e-09 36.5 1.3 3.4e-09 36.4 1.3 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KII68759.1 - 8.4e-07 28.6 0.8 1e-06 28.3 0.8 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase QRPTase_C PF01729.19 KII68759.1 - 0.0086 15.9 0.8 0.012 15.4 0.8 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain MctB PF11382.8 KII68759.1 - 0.038 13.7 0.2 0.043 13.5 0.2 1.0 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB PRTase_2 PF15609.6 KII68759.1 - 0.069 12.6 0.2 0.081 12.4 0.2 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase CDKN3 PF05706.12 KII68759.1 - 0.076 12.7 0.1 0.087 12.5 0.1 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Pribosyltran_N PF13793.6 KII68760.1 - 4.2e-43 146.0 0.0 5.3e-43 145.7 0.0 1.1 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Sortilin-Vps10 PF15902.5 KII68761.1 - 7.2e-09 34.9 4.0 2.2e-07 30.0 1.8 2.4 2 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII68761.1 - 0.0003 20.4 4.1 1.1 9.5 0.1 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF4245 PF14030.6 KII68768.1 - 0.024 14.7 0.1 0.037 14.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) UTP25 PF06862.12 KII68771.1 - 0.0023 16.8 0.3 0.0026 16.6 0.3 1.0 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 zinc_ribbon_2 PF13240.6 KII68771.1 - 0.027 14.2 4.8 3.1 7.6 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DUF5409 PF17421.2 KII68771.1 - 0.06 14.1 0.7 0.1 13.4 0.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5409) sCache_3_3 PF17202.4 KII68771.1 - 0.14 12.6 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Single cache domain 3 zf-CCHC PF00098.23 KII68771.1 - 0.22 11.7 6.8 1.6 8.9 1.2 2.5 2 0 0 2 2 2 0 Zinc knuckle DZR PF12773.7 KII68771.1 - 0.71 9.9 6.0 3.6 7.7 6.0 2.0 1 1 0 1 1 1 0 Double zinc ribbon RT_RNaseH PF17917.1 KII68772.1 - 3e-05 24.3 0.0 0.00032 20.9 0.0 1.9 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII68772.1 - 4.7e-05 23.4 0.0 5.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF5446 PF17522.2 KII68773.1 - 0.0013 18.9 14.3 6.1 7.1 0.2 4.6 1 1 5 6 6 6 6 Family of unknown function (DUF5446) DUF4382 PF14321.6 KII68773.1 - 0.022 15.0 0.6 3.1 8.0 0.6 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4382) Meleagrin PF08189.11 KII68774.1 - 0.045 13.4 0.5 0.071 12.8 0.5 1.4 1 0 0 1 1 1 0 Meleagrin/Cygnin family Asp_protease_2 PF13650.6 KII68775.1 - 3.9e-07 30.6 0.0 5.4e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII68775.1 - 1.5e-06 28.7 0.0 2e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII68775.1 - 0.00019 21.7 0.0 0.00024 21.4 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 KII68775.1 - 0.0029 17.6 3.4 0.0029 17.6 3.4 2.6 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_6 PF15288.6 KII68775.1 - 0.059 13.2 2.2 0.059 13.2 2.2 2.2 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 KII68775.1 - 0.067 12.9 8.2 0.74 9.6 1.3 2.4 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 KII68775.1 - 0.21 11.5 13.2 0.28 11.0 2.7 2.8 2 1 0 2 2 2 0 Zinc knuckle PHD_4 PF16866.5 KII68775.1 - 0.25 11.5 3.8 0.15 12.2 1.7 1.6 2 0 0 2 2 2 0 PHD-finger zf-CCHC_4 PF14392.6 KII68775.1 - 0.71 9.7 6.7 0.22 11.3 1.5 2.6 2 1 1 3 3 3 0 Zinc knuckle Ribosomal_L37e PF01907.19 KII68775.1 - 1.6 8.9 6.9 6.5 7.0 5.9 2.2 1 1 1 2 2 2 0 Ribosomal protein L37e RT_RNaseH PF17917.1 KII68776.1 - 1e-34 119.0 0.0 1.6e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII68776.1 - 2.7e-25 88.3 0.0 4.6e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII68777.1 - 4.5e-25 88.1 0.1 7.9e-25 87.4 0.1 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII68777.1 - 2e-17 63.0 0.2 5e-17 61.7 0.2 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII68777.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII68777.1 - 0.021 15.1 0.0 0.04 14.1 0.0 1.4 1 0 0 1 1 1 0 DDE domain Asp_protease_2 PF13650.6 KII68781.1 - 9.5e-07 29.4 0.0 1.6e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII68781.1 - 6.7e-06 26.6 0.0 1.1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII68781.1 - 0.00044 20.5 0.0 0.00078 19.7 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 KII68781.1 - 0.006 16.6 3.4 0.006 16.6 3.4 2.6 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_5 PF14787.6 KII68781.1 - 0.25 11.1 8.2 1.6 8.5 1.3 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 KII68781.1 - 0.68 9.8 12.6 0.56 10.1 2.7 2.8 2 1 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 KII68781.1 - 1.2 9.1 7.6 0.12 12.2 2.2 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII68781.1 - 1.6 8.5 6.1 0.43 10.3 1.4 2.5 2 1 1 3 3 3 0 Zinc knuckle RT_RNaseH PF17917.1 KII68782.1 - 1e-33 115.7 0.0 1.9e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII68782.1 - 2.2e-24 85.4 0.0 4.7e-24 84.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII68782.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Integrase zinc binding domain Pex24p PF06398.11 KII68786.1 - 0.37 9.7 3.6 0.46 9.4 3.2 1.3 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin zf-CCHC PF00098.23 KII68788.1 - 0.002 18.1 11.9 0.023 14.8 4.2 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 KII68788.1 - 0.35 10.6 6.0 0.77 9.5 1.0 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 KII68788.1 - 5.6 6.8 11.5 0.5 10.1 5.0 2.3 2 0 0 2 2 2 0 C2H2 zinc-finger Integrase_H2C2 PF17921.1 KII68790.1 - 5.1e-11 42.5 0.7 8.8e-11 41.8 0.1 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain C1_2 PF03107.16 KII68790.1 - 0.1 12.9 1.1 0.17 12.2 1.1 1.4 1 0 0 1 1 1 0 C1 domain SeqA_N PF17206.3 KII68794.1 - 0.16 11.3 0.0 0.49 9.7 0.0 1.8 2 0 0 2 2 2 0 SeqA protein N-terminal domain RE_EcoO109I PF14511.6 KII68795.1 - 0.078 12.6 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Type II restriction endonuclease EcoO109I HalOD1 PF18545.1 KII68798.1 - 0.002 18.4 0.1 0.0064 16.7 0.1 1.7 2 0 0 2 2 2 1 Halobacterial output domain 1 Peptidase_S9 PF00326.21 KII68801.1 - 9.4e-17 61.2 0.0 1.4e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KII68801.1 - 1e-06 28.2 0.0 0.012 14.9 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 KII68801.1 - 9.7e-06 25.3 0.0 0.00017 21.2 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 KII68801.1 - 0.00028 20.6 0.0 0.13 11.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DUF4838 PF16126.5 KII68802.1 - 0.062 12.7 1.1 0.077 12.4 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) Metallophos PF00149.28 KII68803.1 - 0.00028 21.5 0.0 0.00032 21.2 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Baculo_RING PF05883.11 KII68803.1 - 0.056 13.4 0.2 0.2 11.6 0.0 1.8 1 1 0 2 2 2 0 Baculovirus U-box/Ring-like domain ISK_Channel PF02060.15 KII68804.1 - 0.14 11.8 0.3 0.43 10.3 0.0 1.7 1 1 1 2 2 2 0 Slow voltage-gated potassium channel Putative_PNPOx PF01243.20 KII68805.1 - 1.7e-20 73.0 0.0 2.4e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 KII68805.1 - 1.9e-07 31.6 0.0 3.1e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 KII68805.1 - 0.00039 20.0 0.1 0.0011 18.5 0.0 1.8 1 1 1 2 2 2 1 Pyridoxamine 5'-phosphate oxidase like DDE_3 PF13358.6 KII68806.1 - 0.00018 21.3 0.6 0.00018 21.3 0.6 1.6 1 1 1 2 2 2 1 DDE superfamily endonuclease DUF1959 PF09218.10 KII68808.1 - 0.095 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) SH3_10 PF17902.1 KII68813.1 - 0.071 13.2 0.5 0.16 12.1 0.1 1.7 2 0 0 2 2 2 0 SH3 domain RT_RNaseH_2 PF17919.1 KII68814.1 - 9e-05 22.5 0.0 0.00029 20.8 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII68814.1 - 0.0044 17.3 0.1 4.8 7.5 0.1 2.5 1 1 0 2 2 2 2 RNase H-like domain found in reverse transcriptase FGAR-AT_linker PF18072.1 KII68814.1 - 0.017 15.6 0.7 0.15 12.6 0.2 2.7 3 0 0 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase linker domain RVT_1 PF00078.27 KII68814.1 - 0.027 14.0 0.0 0.05 13.1 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF190 PF02641.15 KII68820.1 - 0.0088 16.4 0.1 1.4 9.3 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized ACR, COG1993 DUF2228 PF10228.9 KII68820.1 - 0.0098 15.7 0.8 0.022 14.5 0.1 1.8 1 1 1 2 2 2 1 Uncharacterised conserved protein (DUF2228) DHHA1 PF02272.19 KII68820.1 - 1.3 9.4 3.9 0.92 9.9 0.3 2.1 2 0 0 2 2 2 0 DHHA1 domain DUF3510 PF12022.8 KII68822.1 - 0.011 16.1 0.6 0.013 15.9 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) DUF89 PF01937.19 KII68826.1 - 0.17 10.8 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF89 PH_17 PF18012.1 KII68826.1 - 0.18 11.6 0.4 0.42 10.4 0.1 1.7 2 0 0 2 2 2 0 PH domain Inos-1-P_synth PF01658.17 KII68827.1 - 1.2 9.4 4.3 0.48 10.7 0.4 1.9 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase Sortilin_C PF15901.5 KII68828.1 - 1.1e-14 55.1 1.6 2e-14 54.3 1.6 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII68828.1 - 1.6e-08 33.8 0.6 0.0028 16.5 0.0 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII68828.1 - 0.0024 17.6 8.2 9.2 6.7 0.0 5.2 6 0 0 6 6 6 3 BNR/Asp-box repeat SNAP PF14938.6 KII68829.1 - 6.1e-12 45.5 7.1 6.8e-12 45.4 7.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII68829.1 - 0.05 13.9 4.4 3.5 8.0 0.2 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII68829.1 - 0.13 12.4 10.6 2.9 8.2 1.7 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII68829.1 - 0.85 9.6 12.3 4.1 7.4 2.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII68829.1 - 2.5 8.5 10.6 9.7 6.7 0.3 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 KII68830.1 - 1.3e-08 34.7 6.0 1.5e-08 34.4 6.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 KII68830.1 - 0.067 13.1 1.7 0.65 10.0 1.4 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII68830.1 - 0.089 12.9 7.7 0.58 10.4 0.7 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII68830.1 - 0.67 10.3 12.0 5.5 7.5 0.1 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KII68830.1 - 0.89 9.7 4.8 3.7 7.8 0.6 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat RVP PF00077.20 KII68831.1 - 3.5e-07 30.5 0.0 4.3e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Peptidase_A2E PF12382.8 KII68831.1 - 0.0032 17.5 0.0 0.0041 17.1 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon peptidase Asp_protease_2 PF13650.6 KII68831.1 - 0.0047 17.5 0.0 0.0074 16.9 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII68831.1 - 0.025 15.2 0.0 0.039 14.5 0.0 1.5 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease RT_RNaseH PF17917.1 KII68832.1 - 3.1e-30 104.5 0.0 5.6e-30 103.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII68832.1 - 9.9e-25 86.5 0.0 1.7e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII68832.1 - 1.1e-08 35.1 0.1 2.3e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII68833.1 - 1.9e-09 37.7 0.0 2.3e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII68833.1 - 0.0019 18.0 0.0 0.0029 17.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF3293 PF11697.8 KII68833.1 - 0.061 13.8 0.0 0.09 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3293) MLVIN_C PF18697.1 KII68834.1 - 0.00047 20.2 0.0 0.00064 19.8 0.0 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain SNAP PF14938.6 KII68835.1 - 3.1e-07 30.1 0.1 4.1e-07 29.7 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII68835.1 - 0.31 11.4 1.5 28 5.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.6 KII68838.1 - 4.6e-05 23.0 0.1 5.7e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SNAD4 PF18750.1 KII68838.1 - 0.057 13.6 0.2 0.24 11.5 0.0 2.0 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC1 PF18769.1 KII68838.1 - 0.07 13.4 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 APOBEC1 SNAP PF14938.6 KII68840.1 - 1.5e-06 27.8 0.2 1.9e-06 27.5 0.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 KII68840.1 - 0.11 12.7 3.6 21 5.6 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.6 KII68842.1 - 0.00061 19.3 0.3 0.0013 18.2 0.0 1.6 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 KII68842.1 - 0.22 11.7 1.8 5.6 7.3 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII68842.1 - 1.6 9.1 3.9 1.2 9.5 0.4 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF919 PF06034.11 KII68843.1 - 0.043 13.7 0.1 0.093 12.6 0.1 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF5300 PF17224.3 KII68844.1 - 0.007 16.6 0.3 0.012 15.8 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5300) SNAP PF14938.6 KII68845.1 - 6.4e-09 35.6 0.1 1e-08 35.0 0.1 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Bcl-2 PF00452.19 KII68845.1 - 0.0089 16.7 0.0 1 10.1 0.0 2.2 1 1 1 2 2 2 2 Apoptosis regulator proteins, Bcl-2 family DUF4909 PF16253.5 KII68846.1 - 0.084 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4909) SNAP PF14938.6 KII68847.1 - 0.00049 19.6 0.1 0.00094 18.7 0.0 1.4 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP MIT PF04212.18 KII68847.1 - 1.1 9.4 3.9 1 9.5 0.4 2.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain VCBS PF13517.6 KII68848.1 - 0.0019 18.8 0.0 0.0078 16.8 0.0 2.1 1 1 0 1 1 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII68848.1 - 0.004 17.2 4.9 0.0052 16.9 1.0 2.6 3 0 0 3 3 3 1 FG-GAP repeat TLP1_add_C PF18313.1 KII68848.1 - 0.0091 15.9 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 Thiolase-like protein type 1 additional C-terminal domain zf-SAP30 PF13866.6 KII68848.1 - 0.06 13.5 0.1 0.21 11.7 0.1 1.9 1 0 0 1 1 1 0 SAP30 zinc-finger THEG4 PF15834.5 KII68848.1 - 0.2 11.7 0.3 0.39 10.7 0.3 1.5 1 0 0 1 1 1 0 Testis highly expressed protein 4 rve PF00665.26 KII68853.1 - 3e-12 46.8 0.0 6.3e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII68853.1 - 3.9e-10 39.7 0.4 7.6e-10 38.8 0.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain FG-GAP PF01839.23 KII68853.1 - 0.0008 19.5 1.0 0.0019 18.3 1.0 1.6 1 0 0 1 1 1 1 FG-GAP repeat VCBS PF13517.6 KII68853.1 - 0.0019 18.7 4.0 0.021 15.4 0.3 2.2 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella rve_3 PF13683.6 KII68853.1 - 0.036 13.8 0.0 0.079 12.7 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain VCBS PF13517.6 KII68855.1 - 0.00046 20.7 1.3 0.027 15.1 0.2 3.3 2 2 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII68855.1 - 0.00056 20.0 3.4 0.0012 19.0 3.4 1.6 1 0 0 1 1 1 1 FG-GAP repeat DUF4387 PF14330.6 KII68855.1 - 0.053 14.2 0.0 0.15 12.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4387) Armet PF10208.9 KII68856.1 - 5.9e-21 74.9 6.4 7.5e-21 74.6 6.4 1.1 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding V-set_CD47 PF08204.11 KII68856.1 - 0.11 12.4 2.5 7.5 6.6 0.3 2.1 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Clathrin_H_link PF13838.6 KII68857.1 - 2.1e-14 53.2 0.0 4e-13 49.1 0.0 2.5 2 0 0 2 2 2 1 Clathrin-H-link Clathrin PF00637.20 KII68857.1 - 2.1e-10 40.6 6.3 6e-10 39.2 3.3 2.7 2 1 0 2 2 2 1 Region in Clathrin and VPS TPR_1 PF00515.28 KII68857.1 - 0.13 12.2 1.5 19 5.3 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat pRN1_helical PF13010.6 KII68860.1 - 0.093 12.7 0.0 0.19 11.7 0.0 1.4 1 1 0 1 1 1 0 Primase helical domain DDE_Tnp_1_7 PF13843.6 KII68862.1 - 1.1e-19 71.0 0.1 1.3e-19 70.7 0.1 1.1 1 0 0 1 1 1 1 Transposase IS4 YbaJ PF10757.9 KII68862.1 - 0.015 15.8 0.0 0.025 15.1 0.0 1.3 1 0 0 1 1 1 0 Biofilm formation regulator YbaJ DNA_ligase_A_M PF01068.21 KII68863.1 - 0.086 12.5 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 ATP dependent DNA ligase domain WEMBL PF05701.11 KII68865.1 - 2.9e-09 36.2 5.8 0.0037 16.0 0.4 2.9 1 1 0 2 2 2 2 Weak chloroplast movement under blue light YfdX PF10938.8 KII68865.1 - 6.3e-08 32.7 0.0 4.6 7.2 0.0 5.1 1 1 4 5 5 5 4 YfdX protein Borrelia_P83 PF05262.11 KII68865.1 - 9.1e-06 24.4 8.1 0.053 12.0 8.1 2.6 1 1 0 1 1 1 1 Borrelia P83/100 protein Golgin_A5 PF09787.9 KII68865.1 - 0.00011 21.8 10.7 0.065 12.7 10.7 2.5 1 1 0 1 1 1 1 Golgin subfamily A member 5 DUF3584 PF12128.8 KII68865.1 - 0.00012 19.8 4.2 0.036 11.6 0.5 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3584) DUF4398 PF14346.6 KII68865.1 - 0.00032 21.2 17.8 1.8e+04 -4.4 17.8 5.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4398) Fez1 PF06818.15 KII68865.1 - 0.026 15.0 5.2 0.18 12.2 5.2 2.0 1 1 0 1 1 1 0 Fez1 DUF2689 PF10894.8 KII68865.1 - 0.48 10.2 27.8 64 3.4 0.4 8.2 1 1 11 12 12 12 0 Protein of unknown function (DUF2689) RVT_1 PF00078.27 KII68868.1 - 8.1e-05 22.2 0.1 0.0001 21.9 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4750 PF15938.5 KII68870.1 - 0.018 14.7 0.5 0.03 14.0 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) MAP17 PF15807.5 KII68870.1 - 0.12 12.6 0.2 0.15 12.3 0.2 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Hum_adeno_E3A PF05393.11 KII68870.1 - 0.13 12.3 2.0 0.15 12.0 1.7 1.3 1 1 0 1 1 1 0 Human adenovirus early E3A glycoprotein 40S_S4_C PF16121.5 KII68870.1 - 0.25 11.0 0.4 0.45 10.2 0.0 1.5 2 0 0 2 2 2 0 40S ribosomal protein S4 C-terminus Rv2175c_C PF18367.1 KII68871.1 - 0.2 11.8 0.1 0.65 10.1 0.0 1.9 2 0 0 2 2 2 0 Rv2175c C-terminal domain of unknown function RVT_1 PF00078.27 KII68873.1 - 9e-19 67.9 0.0 1.1e-18 67.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_Tnp_IS1595 PF12762.7 KII68875.1 - 3e-05 24.1 0.1 0.00021 21.3 0.1 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain AA_synth PF06684.11 KII68877.1 - 0.09 12.3 0.0 0.21 11.1 0.0 1.5 2 0 0 2 2 2 0 Amino acid synthesis AA_synth PF06684.11 KII68879.1 - 0.09 12.3 0.0 0.21 11.1 0.0 1.5 2 0 0 2 2 2 0 Amino acid synthesis rve PF00665.26 KII68883.1 - 6.7e-17 61.8 0.0 1.2e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII68883.1 - 0.0018 18.0 0.0 0.0039 16.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII68883.1 - 0.0064 16.6 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Sortilin-Vps10 PF15902.5 KII68884.1 - 0.00025 20.0 0.0 0.0056 15.5 0.1 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII68885.1 - 5.1e-15 55.4 62.0 0.0001 22.4 11.5 4.4 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A Orthopox_A36R PF05950.11 KII68886.1 - 0.18 12.0 0.8 0.25 11.5 0.8 1.2 1 0 0 1 1 1 0 Orthopoxvirus A36R protein PAG PF15347.6 KII68886.1 - 0.33 9.9 0.5 0.37 9.7 0.5 1.1 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched EVI2A PF05399.11 KII68886.1 - 0.38 10.3 4.4 0.5 9.9 4.4 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Syndecan PF01034.20 KII68886.1 - 0.7 9.9 2.5 1.1 9.2 2.5 1.3 1 0 0 1 1 1 0 Syndecan domain UPF0560 PF10577.9 KII68886.1 - 1.7 7.0 2.9 2.1 6.7 2.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ldl_recept_a PF00057.18 KII68887.1 - 9.1e-10 38.6 36.5 1.3e-05 25.3 14.6 2.5 1 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 KII68887.1 - 7.6 6.3 21.0 55 3.5 20.9 1.9 1 1 0 1 1 1 0 Glucosidase II beta subunit-like Sortilin-Vps10 PF15902.5 KII68888.1 - 2.3e-07 30.0 3.0 0.0026 16.6 0.1 3.3 2 1 1 3 3 3 3 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII68888.1 - 0.00097 19.5 0.1 0.0015 18.9 0.1 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII68888.1 - 0.022 14.7 6.5 0.36 11.0 0.2 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat Nucleoside_tran PF01733.18 KII68891.1 - 4.4e-10 39.4 3.7 4.8e-10 39.3 3.7 1.0 1 0 0 1 1 1 1 Nucleoside transporter DUF2101 PF09874.9 KII68891.1 - 0.14 11.8 6.6 0.16 11.6 6.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) Ldl_recept_a PF00057.18 KII68892.1 - 1.2e-27 95.8 46.2 1e-10 41.6 11.8 3.3 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A PUA PF01472.20 KII68892.1 - 0.18 11.8 0.3 1.4 9.0 0.2 2.0 1 1 1 2 2 2 0 PUA domain DUF4505 PF14956.6 KII68897.1 - 0.035 13.9 0.1 3.8 7.2 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4505) SPOR PF05036.13 KII68903.1 - 0.024 15.0 0.1 0.043 14.2 0.1 1.5 1 0 0 1 1 1 0 Sporulation related domain Ldl_recept_a PF00057.18 KII68906.1 - 6.1e-10 39.2 30.9 3.3e-05 24.0 13.7 2.4 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 KII68906.1 - 5.4 6.8 16.6 29 4.4 16.6 1.9 1 1 0 1 1 1 0 Glucosidase II beta subunit-like Ldl_recept_a PF00057.18 KII68908.1 - 2.6e-11 43.5 31.8 1.2e-05 25.4 12.8 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 KII68908.1 - 3.7 7.3 19.7 26 4.6 19.8 1.8 1 1 0 1 1 1 0 Glucosidase II beta subunit-like Ldl_recept_a PF00057.18 KII68909.1 - 6.4e-23 80.7 45.4 5.3e-11 42.6 8.3 3.3 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Defensin_beta PF00711.19 KII68909.1 - 2.5 8.2 10.2 0.49 10.5 1.2 3.1 3 0 0 3 3 3 0 Beta defensin RT_RNaseH_2 PF17919.1 KII68913.1 - 3.7e-10 39.7 0.1 1.3e-09 38.0 0.0 1.9 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII68913.1 - 1.3e-09 38.2 0.0 5.1e-09 36.4 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII68913.1 - 1.5e-09 37.9 0.5 3.4e-09 36.7 0.5 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII68913.1 - 2.2e-07 30.6 0.1 0.012 15.1 0.0 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) MetRS-N PF09635.10 KII68913.1 - 0.023 15.2 0.1 0.15 12.6 0.1 2.2 2 0 0 2 2 2 0 MetRS-N binding domain RT_RNaseH_2 PF17919.1 KII68915.1 - 6.5e-12 45.4 0.0 8.7e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII68915.1 - 3.1e-09 37.1 0.0 4.8e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII68916.1 - 1.6e-15 57.2 0.1 2.5e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 KII68916.1 - 0.00013 22.2 0.0 0.0004 20.7 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease Spuma_A9PTase PF03539.14 KII68916.1 - 0.00031 20.9 0.0 0.0031 17.6 0.0 2.4 2 1 0 2 2 2 1 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.6 KII68916.1 - 0.002 18.7 0.0 0.0034 17.9 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII68916.1 - 0.0079 16.8 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease rve PF00665.26 KII68917.1 - 1.4e-13 51.1 0.0 3.8e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII68917.1 - 2.6e-13 49.8 0.0 5.8e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 KII68917.1 - 8.5e-10 38.6 0.0 1.8e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII68917.1 - 1e-06 28.9 0.4 0.0033 17.7 0.0 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 KII68917.1 - 0.0011 19.1 0.0 0.003 17.7 0.0 1.8 1 0 0 1 1 1 1 H2C2 zinc finger DDE_3 PF13358.6 KII68918.1 - 2.7e-15 56.4 0.0 3.2e-15 56.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH_2 PF17919.1 KII68919.1 - 8.7e-16 57.8 0.1 1.8e-15 56.8 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII68919.1 - 6.5e-14 52.0 0.1 1.1e-13 51.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII68919.1 - 4.7e-12 46.1 0.1 8.4e-12 45.3 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Guanylate_kin PF00625.21 KII68919.1 - 0.16 11.6 0.8 1.3 8.7 0.1 2.3 2 1 0 2 2 2 0 Guanylate kinase Integrase_H2C2 PF17921.1 KII68920.1 - 2.9e-13 49.7 0.7 7.6e-13 48.4 0.5 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII68920.1 - 2.1e-11 44.0 0.0 2.4e-11 43.8 0.0 1.3 1 1 0 1 1 1 1 Integrase core domain HTH_33 PF13592.6 KII68921.1 - 7.3e-07 28.7 0.0 1.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix DDE_3 PF13358.6 KII68921.1 - 1.9e-06 27.7 0.0 2.7e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3377 PF11857.8 KII68927.1 - 0.013 15.4 0.3 0.056 13.4 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Glycophorin_A PF01102.18 KII68927.1 - 0.094 13.0 0.1 0.21 11.9 0.1 1.6 2 0 0 2 2 2 0 Glycophorin A FLYWCH PF04500.16 KII68930.1 - 4.2e-06 26.8 0.1 8.8e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain EamA PF00892.20 KII68931.1 - 3e-18 66.3 41.2 5.6e-09 36.3 12.8 2.5 2 1 0 2 2 2 2 EamA-like transporter family EmrE PF13536.6 KII68931.1 - 0.0058 16.3 5.4 0.0058 16.3 5.4 2.5 1 1 1 2 2 2 1 Putative multidrug resistance efflux transporter Leptin PF02024.15 KII68933.1 - 0.004 17.0 0.2 0.004 17.0 0.2 1.7 2 0 0 2 2 2 1 Leptin Syntaxin-6_N PF09177.11 KII68933.1 - 0.011 16.2 5.3 0.27 11.8 5.3 2.2 1 1 0 1 1 1 0 Syntaxin 6, N-terminal FliJ PF02050.16 KII68933.1 - 0.024 14.8 6.7 1.3 9.3 1.8 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein Rx_N PF18052.1 KII68933.1 - 0.04 14.2 1.6 0.3 11.4 0.1 2.4 2 1 0 2 2 2 0 Rx N-terminal domain HR1 PF02185.16 KII68933.1 - 0.062 13.4 6.1 6 7.1 0.2 3.3 3 0 0 3 3 3 0 Hr1 repeat CENP-F_N PF10481.9 KII68933.1 - 0.071 12.7 8.5 0.089 12.4 8.5 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain DUF3510 PF12022.8 KII68933.1 - 0.1 13.0 1.5 0.52 10.7 1.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) Exonuc_VII_L PF02601.15 KII68933.1 - 0.29 10.7 5.5 0.35 10.4 5.5 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Phage_pRha PF09669.10 KII68933.1 - 0.29 11.7 5.5 0.18 12.4 2.9 2.0 2 1 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) KxDL PF10241.9 KII68933.1 - 0.3 11.4 6.8 2.3 8.6 0.6 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein Vac_Fusion PF02346.16 KII68933.1 - 0.37 10.4 6.3 1.6 8.4 0.4 2.7 2 1 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DASH_Duo1 PF08651.10 KII68933.1 - 0.64 9.8 9.4 5 7.0 2.6 2.7 2 1 1 3 3 3 0 DASH complex subunit Duo1 Glutaredoxin2_C PF04399.13 KII68933.1 - 3.8 7.4 6.5 2.3 8.0 1.1 2.4 1 1 0 2 2 2 0 Glutaredoxin 2, C terminal domain SNAP PF14938.6 KII68934.1 - 6.3e-08 32.4 0.9 8.3e-08 32.0 0.9 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 KII68934.1 - 2.2e-05 24.1 3.9 0.48 10.3 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII68934.1 - 0.00041 20.4 2.6 2.5 8.5 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII68934.1 - 0.00096 19.1 4.6 0.42 10.8 0.3 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII68934.1 - 0.01 16.1 2.4 2.2 8.7 0.2 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat Rsa3 PF14615.6 KII68934.1 - 0.099 12.2 0.5 29 4.3 0.0 3.5 3 0 0 3 3 3 0 Ribosome-assembly protein 3 Tetraspanin PF00335.20 KII68936.1 - 6.1e-15 55.5 15.9 6.6e-15 55.4 15.9 1.1 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 KII68936.1 - 0.17 11.5 10.9 3.1 7.4 6.7 2.1 2 0 0 2 2 2 0 SUR7/PalI family KleE PF17394.2 KII68936.1 - 0.36 11.1 2.9 5.8 7.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized KleE stable inheritance protein Claudin_2 PF13903.6 KII68936.1 - 1.5 8.5 6.9 0.69 9.6 4.2 1.7 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction MgtE PF01769.16 KII68936.1 - 7.9 6.9 12.4 1.9 8.9 6.5 2.1 2 0 0 2 2 2 0 Divalent cation transporter Tetraspanin PF00335.20 KII68939.1 - 3.8e-10 39.9 3.6 4.9e-10 39.5 3.6 1.1 1 0 0 1 1 1 1 Tetraspanin family DDE_Tnp_IS1595 PF12762.7 KII68941.1 - 1e-08 35.3 0.1 7.1e-08 32.6 0.1 2.1 1 1 1 2 2 2 1 ISXO2-like transposase domain Tetraspanin PF00335.20 KII68942.1 - 0.00029 20.6 11.1 0.00034 20.4 11.1 1.2 1 0 0 1 1 1 1 Tetraspanin family SirB PF04247.12 KII68942.1 - 0.01 15.9 2.2 0.016 15.3 2.2 1.3 1 0 0 1 1 1 0 Invasion gene expression up-regulator, SirB SDF PF00375.18 KII68942.1 - 0.016 14.3 4.7 0.21 10.6 4.1 2.0 1 1 1 2 2 2 0 Sodium:dicarboxylate symporter family DUF3360 PF11840.8 KII68942.1 - 0.023 13.4 0.2 0.027 13.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3360) Cytochrom_B_C PF00032.17 KII68942.1 - 0.09 13.1 2.8 0.11 12.7 2.8 1.3 1 0 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD DUF2981 PF11200.8 KII68942.1 - 0.74 9.5 4.8 0.94 9.2 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Tetraspanin PF00335.20 KII68943.1 - 1.4e-15 57.6 8.6 2e-15 57.1 8.6 1.1 1 0 0 1 1 1 1 Tetraspanin family MNNL PF07657.13 KII68943.1 - 0.00035 20.5 1.7 0.0006 19.8 1.7 1.3 1 0 0 1 1 1 1 N terminus of Notch ligand DUF4212 PF13937.6 KII68943.1 - 7.7 7.0 13.9 2.8 8.4 0.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) LZ3wCH PF18517.1 KII68944.1 - 0.14 12.2 0.6 0.27 11.4 0.6 1.4 1 0 0 1 1 1 0 Leucine zipper with capping helix domain Tetraspanin PF00335.20 KII68945.1 - 4.7e-13 49.4 8.9 5.6e-13 49.1 8.9 1.1 1 0 0 1 1 1 1 Tetraspanin family COX1 PF00115.20 KII68945.1 - 0.041 12.8 3.1 0.015 14.2 0.9 1.3 2 0 0 2 2 2 0 Cytochrome C and Quinol oxidase polypeptide I Per1 PF04080.13 KII68945.1 - 0.055 13.2 0.4 0.079 12.7 0.4 1.2 1 0 0 1 1 1 0 Per1-like family Glycophorin_A PF01102.18 KII68946.1 - 0.065 13.5 0.0 0.08 13.2 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A Adeno_E3_CR2 PF02439.15 KII68946.1 - 0.2 11.4 2.1 0.4 10.5 2.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 RIFIN PF02009.16 KII68949.1 - 0.002 18.1 0.4 0.0031 17.4 0.3 1.3 1 1 0 1 1 1 1 Rifin Orf78 PF06024.12 KII68949.1 - 0.014 15.6 0.0 0.033 14.5 0.0 1.6 1 0 0 1 1 1 0 Orf78 (ac78) DNA_pol_phi PF04931.13 KII68949.1 - 0.018 13.2 3.9 0.022 12.9 3.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi LRRC37AB_C PF14914.6 KII68949.1 - 0.019 14.9 1.5 0.034 14.0 1.5 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Insulin_TMD PF17870.1 KII68949.1 - 0.047 13.8 2.4 0.1 12.7 2.4 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Pox_Ag35 PF03286.14 KII68949.1 - 0.32 10.7 7.5 0.56 10.0 7.5 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FYDLN_acid PF09538.10 KII68949.1 - 8.1 7.2 15.1 0.74 10.5 10.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) AstA PF04958.12 KII68950.1 - 0.038 12.6 0.0 0.056 12.0 0.0 1.2 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit Serpin PF00079.20 KII68952.1 - 2e-51 175.5 4.1 2.2e-51 175.3 4.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII68955.1 - 4.9e-47 161.0 6.0 5.3e-47 160.9 6.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SRTM1 PF15872.5 KII68957.1 - 0.0083 16.3 0.1 0.016 15.4 0.1 1.4 1 0 0 1 1 1 1 Serine-rich and transmembrane domain-containing protein 1 EssA PF10661.9 KII68957.1 - 0.021 14.7 0.6 0.041 13.7 0.6 1.5 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA TMEM154 PF15102.6 KII68957.1 - 0.057 13.3 0.4 0.099 12.5 0.4 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF5123 PF17161.4 KII68957.1 - 0.098 13.7 1.0 0.098 13.7 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5123) Adeno_E3_CR2 PF02439.15 KII68957.1 - 0.27 11.0 4.5 0.5 10.2 4.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DDE_3 PF13358.6 KII68958.1 - 9.6e-30 103.3 0.1 1.7e-29 102.5 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII68958.1 - 1.1e-07 31.5 0.2 6.1e-05 22.7 0.0 3.3 3 1 0 3 3 3 1 Homeodomain-like domain HTH_29 PF13551.6 KII68958.1 - 3.5e-06 26.9 0.5 7.2e-05 22.7 0.0 2.9 3 0 0 3 3 3 1 Winged helix-turn helix HTH_38 PF13936.6 KII68958.1 - 7.9e-06 25.5 0.2 0.0012 18.5 0.0 3.4 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_28 PF13518.6 KII68958.1 - 1.7e-05 24.8 0.2 0.00016 21.7 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 KII68958.1 - 0.00027 21.5 0.0 0.001 19.6 0.0 2.1 1 1 0 1 1 1 1 Homeodomain-like domain PAX PF00292.18 KII68958.1 - 0.0048 16.8 0.2 0.0097 15.8 0.2 1.6 1 0 0 1 1 1 1 'Paired box' domain HTH_33 PF13592.6 KII68958.1 - 0.018 14.7 0.0 0.045 13.4 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII68958.1 - 0.022 15.0 1.9 0.029 14.6 0.2 2.2 3 0 0 3 3 1 0 Transposase DDE_Tnp_ISAZ013 PF07592.11 KII68958.1 - 0.048 12.6 0.1 3.6 6.5 0.1 2.2 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain HTH_Tnp_IS630 PF01710.16 KII68958.1 - 0.051 13.6 0.8 0.16 12.0 0.2 2.0 1 1 0 2 2 2 0 Transposase HTH_Crp_2 PF13545.6 KII68958.1 - 0.054 13.5 0.0 0.17 11.9 0.0 1.9 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain RapH_N PF18801.1 KII68958.1 - 0.066 13.3 0.3 1.3 9.2 0.1 2.5 2 0 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal HTH_7 PF02796.15 KII68958.1 - 0.081 13.0 0.2 0.48 10.5 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase TrmB PF01978.19 KII68958.1 - 0.1 12.5 0.1 0.53 10.2 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB RIFIN PF02009.16 KII68959.1 - 0.048 13.5 0.9 0.071 13.0 0.9 1.2 1 0 0 1 1 1 0 Rifin DUF4448 PF14610.6 KII68959.1 - 0.23 11.2 2.2 1.3 8.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF1676 PF07898.13 KII68959.1 - 0.3 11.1 0.1 0.3 11.1 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) TMEM154 PF15102.6 KII68959.1 - 0.33 10.9 4.6 0.14 12.0 1.7 1.8 2 0 0 2 2 2 0 TMEM154 protein family DUF3827 PF12877.7 KII68959.1 - 0.51 8.7 2.8 0.74 8.1 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) CagE_TrbE_VirB PF03135.14 KII68960.1 - 0.011 15.8 3.6 0.45 10.6 0.1 2.5 3 0 0 3 3 3 0 CagE, TrbE, VirB family, component of type IV transporter system DUF2012 PF09430.10 KII68960.1 - 0.053 13.6 3.3 3.7 7.7 0.1 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF2012) SRP54 PF00448.22 KII68970.1 - 5.3e-17 62.1 0.0 1.4e-16 60.7 0.0 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54 PF00448.22 KII68971.1 - 6.5e-19 68.3 0.0 1e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MeaB PF03308.16 KII68971.1 - 0.00025 20.1 0.0 0.00031 19.8 0.0 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 KII68971.1 - 0.0011 18.4 0.0 0.0021 17.6 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_31 PF13614.6 KII68971.1 - 0.002 18.1 0.3 0.007 16.3 0.0 1.8 1 1 1 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 KII68971.1 - 0.0021 17.3 0.1 0.0077 15.5 0.0 1.7 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_14 PF13173.6 KII68971.1 - 0.0028 17.7 0.0 0.0097 15.9 0.0 1.7 1 1 1 2 2 2 1 AAA domain KAP_NTPase PF07693.14 KII68971.1 - 0.0045 16.3 0.0 0.0065 15.7 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain AAA_16 PF13191.6 KII68971.1 - 0.0048 17.3 0.0 0.0095 16.3 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain CbiA PF01656.23 KII68971.1 - 0.011 15.8 0.1 0.034 14.2 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 KII68971.1 - 0.021 15.0 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Prismane PF03063.20 KII68971.1 - 0.038 12.7 0.1 0.038 12.7 0.1 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family APS_kinase PF01583.20 KII68971.1 - 0.064 13.1 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase ParA PF10609.9 KII68971.1 - 0.065 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase PIF1 PF05970.14 KII68971.1 - 0.065 12.4 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase ABC_tran PF00005.27 KII68971.1 - 0.078 13.5 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_10 PF12846.7 KII68971.1 - 0.088 11.7 0.1 0.2 10.5 0.0 1.5 1 1 1 2 2 2 0 AAA-like domain RsgA_GTPase PF03193.16 KII68971.1 - 0.091 12.7 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 KII68971.1 - 0.092 12.4 0.4 0.14 11.8 0.2 1.4 1 1 0 1 1 1 0 AAA ATPase domain SRP54_N PF02881.19 KII68971.1 - 0.093 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, helical bundle domain KTI12 PF08433.10 KII68971.1 - 0.11 12.0 0.1 0.22 11.0 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 KII68971.1 - 0.11 12.4 0.1 0.36 10.7 0.0 1.7 1 1 1 2 2 2 0 NTPase AAA PF00004.29 KII68971.1 - 0.13 12.7 0.0 0.37 11.2 0.0 1.7 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KII68971.1 - 0.13 12.0 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 KII68971.1 - 0.17 11.0 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Zeta_toxin PF06414.12 KII68971.1 - 0.17 11.1 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Dynamin_N PF00350.23 KII68973.1 - 1.6e-20 73.9 2.3 8.9e-14 51.9 0.0 2.1 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.23 KII68973.1 - 0.0011 19.0 0.2 0.013 15.6 0.2 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 KII68973.1 - 0.036 14.3 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 KII68973.1 - 0.038 13.4 0.0 0.053 12.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AIG1 PF04548.16 KII68973.1 - 0.095 12.0 1.0 1.9 7.8 1.0 2.2 1 1 0 1 1 1 0 AIG1 family UTP15_C PF09384.10 KII68973.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 UTP15 C terminal FtsK_SpoIIIE PF01580.18 KII68973.1 - 0.13 11.6 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.6 KII68973.1 - 0.17 12.3 0.0 0.26 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DNA_pol3_a_NII PF11490.8 KII68975.1 - 0.006 16.5 1.7 0.014 15.3 1.7 1.6 1 0 0 1 1 1 1 DNA polymerase III polC-type N-terminus II EB_dh PF09459.10 KII68975.1 - 0.13 12.2 0.2 0.17 11.8 0.2 1.1 1 0 0 1 1 1 0 Ethylbenzene dehydrogenase Kelch_6 PF13964.6 KII68978.1 - 6.6e-27 92.9 15.8 7.5e-06 26.0 0.1 6.2 5 1 1 6 6 6 6 Kelch motif Kelch_1 PF01344.25 KII68978.1 - 6.2e-23 80.1 15.8 1.3e-06 27.9 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KII68978.1 - 3.8e-18 65.2 12.9 0.0028 17.6 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 KII68978.1 - 4.6e-16 58.4 8.3 0.0056 16.7 0.0 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 KII68978.1 - 1.3e-13 50.9 11.4 0.0059 16.9 0.0 6.5 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KII68978.1 - 1.5e-06 28.0 12.4 1.4 9.0 0.1 6.3 6 0 0 6 6 6 3 Kelch motif zf-C2H2 PF00096.26 KII68979.1 - 0.00017 21.8 5.2 0.85 10.2 0.0 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII68979.1 - 0.001 19.7 5.4 2 9.5 0.6 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf_Hakai PF18408.1 KII68979.1 - 0.0046 16.6 5.8 0.0054 16.4 2.7 2.6 2 0 0 2 2 2 1 C2H2 Hakai zinc finger domain zf-Di19 PF05605.12 KII68979.1 - 0.017 15.4 1.4 0.026 14.8 0.1 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-TRAF PF02176.18 KII68979.1 - 0.043 14.5 6.0 0.13 12.9 1.6 2.4 2 0 0 2 2 2 0 TRAF-type zinc finger zf_C2H2_ZHX PF18387.1 KII68979.1 - 0.073 12.7 1.9 0.2 11.3 0.1 2.2 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 KII68979.1 - 1.9 9.1 11.8 1.7 9.2 0.1 3.9 4 0 0 4 4 4 0 Zinc-finger double domain AAA PF00004.29 KII68980.1 - 5.6e-09 36.5 0.0 1.1e-08 35.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KII68980.1 - 0.00011 22.2 0.0 0.00046 20.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Polyoma_lg_T_C PF06431.11 KII68980.1 - 0.00012 21.1 0.0 0.00017 20.6 0.0 1.2 1 0 0 1 1 1 1 Polyomavirus large T antigen C-terminus ATPase PF06745.13 KII68980.1 - 0.00026 20.4 0.0 0.00048 19.5 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_7 PF12775.7 KII68980.1 - 0.00086 18.9 0.1 0.002 17.6 0.1 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 KII68980.1 - 0.00088 19.8 0.3 0.0023 18.5 0.1 1.8 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 KII68980.1 - 0.0013 18.6 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 Deoxynucleoside kinase ABC_tran PF00005.27 KII68980.1 - 0.0014 19.2 0.4 0.025 15.1 0.1 2.2 2 0 0 2 2 2 1 ABC transporter TsaE PF02367.17 KII68980.1 - 0.0032 17.5 0.0 0.0052 16.8 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 KII68980.1 - 0.0042 16.3 0.1 0.01 15.0 0.1 1.6 1 1 1 2 2 2 1 NB-ARC domain RuvB_N PF05496.12 KII68980.1 - 0.0051 16.6 0.0 0.0074 16.0 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KII68980.1 - 0.0064 16.4 1.1 0.038 13.9 0.3 2.1 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 KII68980.1 - 0.0073 16.7 0.1 0.38 11.1 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.26 KII68980.1 - 0.0079 15.9 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain RNA_helicase PF00910.22 KII68980.1 - 0.01 16.2 1.0 0.41 11.0 0.1 2.7 2 2 0 2 2 2 0 RNA helicase AAA_8 PF12780.7 KII68980.1 - 0.01 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 T2SSE PF00437.20 KII68980.1 - 0.013 14.6 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.14 KII68980.1 - 0.014 15.4 0.0 0.033 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 KII68980.1 - 0.022 14.7 0.2 0.22 11.4 0.1 2.2 1 1 1 2 2 2 0 NACHT domain AAA_19 PF13245.6 KII68980.1 - 0.026 14.9 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 KII68980.1 - 0.028 14.6 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Cytidylate_kin2 PF13189.6 KII68980.1 - 0.032 14.4 0.1 0.1 12.7 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_22 PF13401.6 KII68980.1 - 0.042 14.1 0.4 0.29 11.4 0.1 2.3 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KII68980.1 - 0.056 13.2 0.7 0.17 11.6 0.5 2.0 1 1 1 2 2 2 0 P-loop containing region of AAA domain TIP49 PF06068.13 KII68980.1 - 0.066 12.4 0.2 0.29 10.3 0.0 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain FtsK_SpoIIIE PF01580.18 KII68980.1 - 0.081 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 KII68980.1 - 0.087 12.1 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin ResIII PF04851.15 KII68980.1 - 0.093 12.7 0.7 0.21 11.6 0.4 1.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Cytidylate_kin PF02224.18 KII68980.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_30 PF13604.6 KII68980.1 - 0.26 11.0 0.3 0.78 9.4 0.2 1.7 1 1 1 2 2 2 0 AAA domain AAA_23 PF13476.6 KII68980.1 - 0.53 10.8 2.7 0.6 10.6 0.3 2.0 1 1 1 2 2 2 0 AAA domain DUF87 PF01935.17 KII68980.1 - 2.2 8.3 5.2 16 5.5 0.3 2.2 1 1 1 2 2 2 0 Helicase HerA, central domain Pkinase PF00069.25 KII68981.1 - 2.8e-62 210.5 0.0 3.5e-62 210.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII68981.1 - 3e-30 105.4 0.0 4e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII68981.1 - 4.7e-08 32.7 0.1 3.3e-06 26.6 0.1 2.2 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.14 KII68981.1 - 0.0057 16.0 0.5 0.0085 15.5 0.5 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KII68981.1 - 0.028 14.0 0.1 0.044 13.4 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 KII68981.1 - 0.14 10.9 0.1 0.18 10.5 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase zf-C2H2_4 PF13894.6 KII68982.1 - 2.7e-07 30.9 8.5 0.017 15.9 1.0 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KII68982.1 - 8e-07 29.2 9.6 0.00018 21.8 1.6 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KII68982.1 - 0.0031 17.9 0.1 0.0031 17.9 0.1 3.3 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_8 PF15909.5 KII68982.1 - 0.046 14.0 5.6 0.13 12.6 4.3 2.1 2 1 1 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 KII68982.1 - 0.22 11.7 8.2 4.4 7.4 2.5 2.7 2 1 0 2 2 2 0 Aberrant zinc-finger zf-H2C2_5 PF13909.6 KII68983.1 - 1.4e-07 31.1 3.4 5.8e-06 26.0 0.0 3.4 4 0 0 4 4 4 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 KII68983.1 - 6.4e-07 29.7 10.5 0.025 15.4 0.4 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 KII68983.1 - 0.0001 22.5 16.0 0.011 16.2 0.9 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf_Hakai PF18408.1 KII68983.1 - 0.00012 21.7 7.4 0.017 14.8 2.9 2.5 2 0 0 2 2 2 2 C2H2 Hakai zinc finger domain zf-H2C2_2 PF13465.6 KII68983.1 - 0.00078 19.8 0.1 0.00078 19.8 0.1 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-TRAF PF02176.18 KII68983.1 - 0.0042 17.7 9.5 0.11 13.2 5.5 2.4 1 1 1 2 2 2 2 TRAF-type zinc finger zf-C2H2_8 PF15909.5 KII68983.1 - 0.0061 16.8 3.1 0.0061 16.8 3.1 1.5 2 0 0 2 2 2 1 C2H2-type zinc ribbon zf-Di19 PF05605.12 KII68983.1 - 0.0094 16.2 3.1 0.01 16.1 1.2 2.1 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding Rhabdo_matrix PF03397.14 KII68983.1 - 0.12 12.2 0.0 1.3 8.8 0.0 2.0 2 0 0 2 2 2 0 Rhabdovirus matrix protein DUF777 PF05606.11 KII68985.1 - 0.011 15.5 0.1 0.021 14.6 0.1 1.4 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF777) zf-C2H2 PF00096.26 KII68985.1 - 0.014 15.9 0.6 0.055 14.0 0.6 2.1 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII68985.1 - 0.02 15.7 0.5 0.02 15.7 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 KII68986.1 - 2.8e-05 24.6 13.0 0.12 13.3 0.1 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KII68986.1 - 0.0043 17.4 0.5 0.0043 17.4 0.5 3.6 4 1 0 4 4 4 1 Zinc-finger double domain Rieske PF00355.26 KII68986.1 - 0.03 14.3 5.3 0.5 10.3 5.3 2.2 1 1 0 1 1 1 0 Rieske [2Fe-2S] domain zf-C2H2 PF00096.26 KII68986.1 - 0.81 10.3 18.5 0.82 10.3 0.3 3.8 3 1 1 4 4 4 0 Zinc finger, C2H2 type DDE_3 PF13358.6 KII68988.1 - 0.0096 15.7 0.4 0.019 14.7 0.3 1.5 1 1 1 2 2 2 1 DDE superfamily endonuclease rve PF00665.26 KII68992.1 - 5.3e-07 29.9 0.0 1e-06 28.9 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain DUF4116 PF13475.6 KII68992.1 - 0.032 14.0 0.9 0.16 11.7 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4116) Dna2 PF08696.11 KII68992.1 - 0.074 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 DNA replication factor Dna2 Integrase_H2C2 PF17921.1 KII68993.1 - 1.4e-07 31.5 0.6 3e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain DUF1759 PF03564.15 KII68994.1 - 1e-07 32.0 0.7 5.5e-07 29.6 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF4553 PF15090.6 KII68995.1 - 0.61 9.0 46.0 0.7 8.8 46.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4553) Ribonuc_L-PSP PF01042.21 KII68997.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Endoribonuclease L-PSP zf-CCCH_4 PF18044.1 KII69000.1 - 5.9e-05 22.8 5.1 5.9e-05 22.8 5.1 3.6 3 1 0 3 3 3 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 KII69000.1 - 0.00052 20.2 2.2 0.28 11.4 0.2 2.3 2 0 0 2 2 2 2 Zinc-finger containing family Torus PF16131.5 KII69000.1 - 0.00072 20.2 1.4 0.067 13.9 0.1 2.3 2 0 0 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 KII69000.1 - 0.00081 19.4 6.5 0.00081 19.4 6.5 4.1 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH PF00642.24 KII69000.1 - 0.062 13.2 16.8 0.084 12.8 1.3 3.2 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Vps51 PF08700.11 KII69000.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Vps51/Vps67 zf-CCCH_2 PF14608.6 KII69000.1 - 0.64 10.6 28.6 0.16 12.5 7.0 3.5 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger Peptidase_M14 PF00246.24 KII69002.1 - 3.1e-59 201.2 0.0 4.4e-59 200.6 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF2817 PF10994.8 KII69002.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Rpr2 PF04032.16 KII69003.1 - 0.021 15.1 0.1 0.021 15.1 0.1 1.8 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain IU_nuc_hydro PF01156.19 KII69005.1 - 2.2e-47 162.1 0.0 2.7e-47 161.8 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Aldo_ket_red PF00248.21 KII69007.1 - 1e-12 47.9 0.1 1.2e-12 47.6 0.1 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Kelch_6 PF13964.6 KII69010.1 - 9.4e-12 44.8 2.3 2e-05 24.7 0.3 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 KII69010.1 - 6.1e-10 38.9 0.1 6.5e-06 26.0 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII69010.1 - 9.7e-08 31.9 0.4 0.0032 17.4 0.1 2.1 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII69010.1 - 2.1e-07 30.6 1.5 0.0024 17.8 0.1 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII69010.1 - 1.7e-06 28.2 3.5 0.15 12.4 0.2 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII69010.1 - 3e-06 26.7 0.2 0.049 13.2 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Ribosomal_S14 PF00253.21 KII69010.1 - 0.13 12.1 0.2 0.3 10.9 0.0 1.8 2 1 0 2 2 2 0 Ribosomal protein S14p/S29e Integrase_H2C2 PF17921.1 KII69011.1 - 8.7e-13 48.2 0.0 1.9e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII69011.1 - 1.9e-06 28.0 0.0 6.1e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII69011.1 - 4.5e-06 26.8 0.0 3e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 H2C2 zinc finger Serpin PF00079.20 KII69014.1 - 4.9e-45 154.4 2.4 6e-45 154.2 2.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.26 KII69016.1 - 3e-06 27.4 0.1 6.4e-06 26.4 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII69016.1 - 0.00033 20.4 0.0 0.0007 19.3 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain TSLP PF15216.6 KII69016.1 - 0.087 13.1 0.3 0.12 12.6 0.3 1.3 1 0 0 1 1 1 0 Thymic stromal lymphopoietin Terminase_2 PF03592.16 KII69017.1 - 0.12 12.9 0.6 21 5.6 0.0 2.5 2 0 0 2 2 2 0 Terminase small subunit Herpes_UL92 PF03048.14 KII69017.1 - 0.16 11.8 7.3 0.068 12.9 3.0 2.4 2 0 0 2 2 2 0 UL92 family RFC1 PF08519.12 KII69020.1 - 0.04 14.1 0.0 0.056 13.6 0.0 1.2 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain Ribosomal_L3 PF00297.22 KII69021.1 - 1.7e-12 47.0 0.1 5.6e-12 45.3 0.1 1.7 1 1 1 2 2 2 1 Ribosomal protein L3 DDE_Tnp_IS1595 PF12762.7 KII69022.1 - 1.8e-11 44.3 0.0 8e-11 42.2 0.0 1.9 2 0 0 2 2 2 1 ISXO2-like transposase domain F-box-like PF12937.7 KII69022.1 - 0.29 11.0 1.5 0.95 9.4 0.2 2.4 2 1 0 2 2 2 0 F-box-like Homeodomain PF00046.29 KII69023.1 - 0.001 18.9 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 Homeodomain Ribonuclease_3 PF00636.26 KII69024.1 - 8.3e-33 113.2 0.0 1.4e-15 57.8 0.0 2.5 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 KII69024.1 - 5.4e-22 78.3 2.3 2.5e-10 40.6 0.1 3.9 4 0 0 4 4 4 3 Ribonuclease-III-like E3_UFM1_ligase PF09743.9 KII69025.1 - 7.5e-38 130.7 0.9 9.3e-38 130.4 0.9 1.0 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 Ribonuclease_3 PF00636.26 KII69027.1 - 9.7e-27 93.7 0.0 1.6e-15 57.6 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 KII69027.1 - 8.3e-17 61.6 0.8 3.3e-06 27.3 0.0 4.0 4 0 0 4 4 4 3 Ribonuclease-III-like Colicin_im PF03857.13 KII69028.1 - 0.15 12.1 0.1 0.62 10.0 0.1 1.8 1 1 1 2 2 2 0 Colicin immunity protein CpcD PF01383.21 KII69029.1 - 0.014 15.7 0.2 0.11 12.7 0.1 2.2 2 0 0 2 2 2 0 CpcD/allophycocyanin linker domain tRNA-synt_1 PF00133.22 KII69030.1 - 7.3e-29 100.5 0.0 1.6e-27 96.0 0.0 2.7 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KII69030.1 - 1.6e-15 57.3 0.9 4.5e-15 55.9 0.9 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KII69030.1 - 1.2e-12 47.3 0.0 2e-07 30.1 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 KII69030.1 - 1.4e-06 27.9 0.0 3.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain VWA PF00092.28 KII69031.1 - 6.7e-05 23.2 0.0 0.00014 22.1 0.0 1.6 1 1 1 2 2 2 1 von Willebrand factor type A domain Cdh1_DBD_1 PF18196.1 KII69031.1 - 0.036 14.4 1.3 0.048 14.0 1.3 1.2 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Cpn60_TCP1 PF00118.24 KII69032.1 - 2.9e-151 504.4 3.0 3.5e-151 504.2 3.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EGF_2 PF07974.13 KII69033.1 - 0.15 12.5 5.9 0.29 11.5 5.9 1.5 1 0 0 1 1 1 0 EGF-like domain SNAP PF14938.6 KII69034.1 - 3e-07 30.2 3.3 7.2e-07 28.9 3.3 1.6 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF5104 PF17117.5 KII69034.1 - 0.067 13.6 1.6 0.087 13.3 0.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5104) Clathrin PF00637.20 KII69034.1 - 0.095 12.6 4.3 3.5 7.5 0.2 2.3 1 1 1 2 2 2 0 Region in Clathrin and VPS DP-EP PF08985.11 KII69038.1 - 0.07 13.3 0.2 0.16 12.1 0.1 1.7 2 0 0 2 2 2 0 DP-EP family tRNA-synt_1 PF00133.22 KII69039.1 - 0.01 14.1 0.0 0.016 13.5 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) Ferrochelatase PF00762.19 KII69040.1 - 7.4e-80 268.4 0.0 1e-79 268.0 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase DDE_Tnp_IS1595 PF12762.7 KII69043.1 - 1.1e-08 35.3 0.1 1.3e-08 35.0 0.1 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Leu_Phe_trans PF03588.14 KII69043.1 - 0.08 12.5 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 Leucyl/phenylalanyl-tRNA protein transferase DnaGprimase_HBD PF16730.5 KII69046.1 - 0.035 14.2 0.1 0.051 13.6 0.1 1.2 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain COesterase PF00135.28 KII69046.1 - 0.091 11.6 0.2 0.091 11.6 0.2 1.4 2 0 0 2 2 2 0 Carboxylesterase family PurL_C PF16904.5 KII69048.1 - 0.039 14.3 0.3 0.48 10.8 0.0 2.3 1 1 1 2 2 2 0 Phosphoribosylformylglycinamidine synthase II C-terminus ETRAMP PF09716.10 KII69050.1 - 0.0079 16.2 0.1 0.016 15.3 0.1 1.9 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Orf78 PF06024.12 KII69050.1 - 0.056 13.7 0.8 0.12 12.7 0.0 1.9 3 0 0 3 3 3 0 Orf78 (ac78) Sid-5 PF17204.3 KII69050.1 - 0.11 12.7 1.0 0.32 11.2 1.0 1.8 1 0 0 1 1 1 0 Sid-5 family Borrelia_orfD PF02999.14 KII69051.1 - 0.11 12.8 0.3 0.23 11.8 0.2 1.6 2 0 0 2 2 2 0 Borrelia orf-D family DUF2370 PF10176.9 KII69054.1 - 0.025 14.3 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Orf78 PF06024.12 KII69054.1 - 0.04 14.2 0.0 0.089 13.1 0.0 1.6 1 0 0 1 1 1 0 Orf78 (ac78) Microtub_bd PF16796.5 KII69054.1 - 0.049 13.6 0.5 0.1 12.5 0.4 1.5 1 1 0 1 1 1 0 Microtubule binding NOA36 PF06524.12 KII69054.1 - 4.7 6.4 8.0 7.4 5.8 8.0 1.3 1 0 0 1 1 1 0 NOA36 protein Orf78 PF06024.12 KII69055.1 - 1.1e-05 25.6 1.0 3.5e-05 24.0 1.0 2.0 1 1 0 1 1 1 1 Orf78 (ac78) DUF2370 PF10176.9 KII69055.1 - 0.0012 18.6 0.4 0.0019 17.9 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) DUF2207 PF09972.9 KII69055.1 - 0.0018 17.1 0.4 0.0096 14.7 0.0 1.9 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) DUF4711 PF15829.5 KII69055.1 - 0.0023 17.9 0.3 0.16 11.9 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4711) RIFIN PF02009.16 KII69055.1 - 0.0036 17.3 0.1 0.0036 17.3 0.1 1.9 2 1 0 2 2 2 1 Rifin LAP1C PF05609.12 KII69055.1 - 0.0082 15.3 0.8 0.011 14.8 0.8 1.2 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) DUF2062 PF09835.9 KII69055.1 - 0.0085 16.0 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2062) Connexin PF00029.19 KII69055.1 - 0.012 15.3 0.7 0.021 14.6 0.7 1.3 1 0 0 1 1 1 0 Connexin DUF4448 PF14610.6 KII69055.1 - 0.017 14.9 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) LRRC37AB_C PF14914.6 KII69055.1 - 0.028 14.3 1.6 0.059 13.3 1.6 1.6 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Zip PF02535.22 KII69055.1 - 0.031 13.5 0.9 0.046 12.9 0.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CrgA PF06781.12 KII69055.1 - 0.039 14.0 0.2 0.11 12.5 0.2 1.8 1 1 0 1 1 1 0 Cell division protein CrgA Endomucin PF07010.12 KII69055.1 - 0.041 13.9 0.0 0.086 12.8 0.0 1.5 1 0 0 1 1 1 0 Endomucin Collectrin PF16959.5 KII69055.1 - 0.079 12.7 0.1 0.24 11.2 0.1 1.8 1 0 0 1 1 1 0 Renal amino acid transporter DUF1506 PF07405.11 KII69055.1 - 0.095 12.9 1.4 0.15 12.2 0.1 2.0 3 0 0 3 3 2 0 Protein of unknown function (DUF1506) Peroxin-13_N PF04088.13 KII69055.1 - 0.12 12.7 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF3899 PF13038.6 KII69055.1 - 0.16 12.5 1.0 0.54 10.8 1.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3899) DUF2951 PF11166.8 KII69055.1 - 0.17 12.2 2.6 0.43 10.8 2.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF4366 PF14283.6 KII69055.1 - 0.17 12.0 10.0 1.7 8.7 10.0 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) TRAP_alpha PF03896.16 KII69055.1 - 0.64 9.2 8.1 0.32 10.2 5.8 1.7 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit PMP1_2 PF08114.11 KII69055.1 - 1.1 9.1 3.6 25 4.7 0.1 2.3 2 0 0 2 2 2 0 ATPase proteolipid family RNA_pol_Rpc4 PF05132.14 KII69055.1 - 4.3 7.7 8.4 7.5 7.0 8.4 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 SDA1 PF05285.12 KII69055.1 - 5 6.5 19.2 7.3 5.9 19.2 1.1 1 0 0 1 1 1 0 SDA1 Pox_Ag35 PF03286.14 KII69055.1 - 8.7 6.1 15.8 15 5.3 15.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ig_3 PF13927.6 KII69056.1 - 4.2e-12 46.5 0.1 5.4e-12 46.1 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KII69056.1 - 4.2e-11 42.8 0.0 5.8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KII69056.1 - 8.5e-07 29.2 0.0 1.2e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KII69056.1 - 5.3e-05 23.3 0.0 0.016 15.3 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KII69056.1 - 0.0048 17.1 0.3 0.016 15.4 0.3 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KII69056.1 - 0.028 14.0 0.2 0.16 11.5 0.1 2.2 2 1 0 2 2 2 0 Immunoglobulin domain Laminin_G_3 PF13385.6 KII69057.1 - 7.9e-09 35.8 0.5 1.1e-08 35.3 0.5 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PAN_2 PF08276.11 KII69057.1 - 0.0046 17.0 5.9 0.011 15.8 5.9 1.6 1 0 0 1 1 1 1 PAN-like domain PAN_4 PF14295.6 KII69057.1 - 0.024 14.5 2.8 0.067 13.1 2.8 1.8 1 0 0 1 1 1 0 PAN domain MANEC PF07502.14 KII69057.1 - 0.94 9.8 19.7 6 7.2 8.1 2.6 1 1 1 2 2 2 0 MANEC domain DDE_Tnp_IS1595 PF12762.7 KII69060.1 - 4.9e-05 23.4 0.0 5.4e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain ScsC_N PF18312.1 KII69060.1 - 0.043 13.6 0.4 0.086 12.7 0.4 1.5 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain NACHT PF05729.12 KII69060.1 - 0.23 11.4 0.0 0.27 11.1 0.0 1.1 1 0 0 1 1 1 0 NACHT domain U71 PF17474.2 KII69061.1 - 0.085 12.8 0.1 0.42 10.6 0.0 2.0 2 0 0 2 2 2 0 Tegument protein UL11 homolog Herpes_UL52 PF03121.15 KII69062.1 - 0.4 10.7 3.9 5.9 6.9 0.0 3.0 2 1 0 2 2 2 0 Herpesviridae UL52/UL70 DNA primase RVT_1 PF00078.27 KII69063.1 - 2e-15 56.9 0.1 3.6e-15 56.1 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) VapB_antitoxin PF09957.9 KII69063.1 - 0.092 12.7 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 Bacterial antitoxin of type II TA system, VapB DUF2481 PF10654.9 KII69063.1 - 0.4 10.7 2.7 1.1 9.2 0.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2481) rve PF00665.26 KII69065.1 - 3e-16 59.7 0.0 4.9e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII69065.1 - 2.1e-05 24.2 0.1 6.2e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain MLVIN_C PF18697.1 KII69065.1 - 0.0023 18.0 0.0 0.0054 16.8 0.0 1.6 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain UN_NPL4 PF11543.8 KII69065.1 - 0.077 13.5 0.0 0.19 12.2 0.0 1.8 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 zf-U11-48K PF05253.12 KII69065.1 - 0.47 10.4 2.4 12 6.0 0.2 2.5 2 0 0 2 2 2 0 U11-48K-like CHHC zinc finger Glyco_transf_10 PF00852.19 KII69068.1 - 3e-34 118.3 1.1 5.5e-34 117.4 1.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Cauli_AT PF03233.13 KII69068.1 - 0.073 13.0 6.9 1.9 8.4 0.2 3.0 1 1 3 4 4 4 0 Aphid transmission protein DUF1298 PF06974.13 KII69069.1 - 0.12 12.3 0.1 0.99 9.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1298) TPR_2 PF07719.17 KII69070.1 - 0.00019 21.3 0.6 0.0052 16.8 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KII69070.1 - 0.044 13.6 0.8 0.13 12.1 0.8 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat rve PF00665.26 KII69071.1 - 3.6e-21 75.5 0.1 4.1e-21 75.4 0.1 1.0 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII69071.1 - 6.3e-07 29.1 0.0 9.9e-06 25.2 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII69071.1 - 0.00061 20.0 0.0 0.00072 19.8 0.0 1.0 1 0 0 1 1 1 1 DDE domain NOC3p PF07540.11 KII69072.1 - 1e-05 25.9 0.1 1.3e-05 25.5 0.1 1.2 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 KII69073.1 - 2.3e-12 47.3 0.2 5e-12 46.2 0.1 1.6 1 1 0 1 1 1 1 CBF/Mak21 family TPK_catalytic PF04263.16 KII69075.1 - 1.2e-26 93.1 0.1 3e-26 91.8 0.0 1.7 3 0 0 3 3 3 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 KII69075.1 - 3.8e-15 55.4 0.0 6.6e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Evr1_Alr PF04777.13 KII69076.1 - 4e-14 52.9 0.0 7.4e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Erv1 / Alr family Zn-ribbon_8 PF09723.10 KII69076.1 - 1.8 8.8 4.5 23 5.2 0.6 2.3 2 0 0 2 2 2 0 Zinc ribbon domain Thioredoxin PF00085.20 KII69077.1 - 1e-14 54.4 0.3 1.6e-14 53.7 0.3 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KII69077.1 - 0.00061 20.2 0.2 0.0011 19.4 0.2 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 KII69077.1 - 0.0026 17.7 0.1 0.0042 17.0 0.1 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 KII69077.1 - 0.0038 17.4 0.0 0.0066 16.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 KII69077.1 - 0.0041 17.4 1.6 0.016 15.5 1.5 2.2 1 1 1 2 2 2 1 Thioredoxin-like Redoxin PF08534.10 KII69077.1 - 0.014 15.1 0.1 0.13 12.0 0.1 2.1 2 0 0 2 2 2 0 Redoxin TraF PF13728.6 KII69077.1 - 0.039 13.8 0.1 0.066 13.0 0.1 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein NTP_transferase PF00483.23 KII69078.1 - 1.7e-13 50.7 0.0 2.3e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KII69078.1 - 1.2e-05 25.8 0.0 1.5e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain SUZ PF12752.7 KII69080.1 - 4.4e-06 27.3 0.0 4.4e-06 27.3 0.0 2.2 3 0 0 3 3 3 1 SUZ domain EpmC PF04315.12 KII69080.1 - 0.0025 17.5 0.1 0.0034 17.1 0.1 1.3 1 1 0 1 1 1 1 Elongation factor P hydroxylase DUF4286 PF14114.6 KII69080.1 - 0.016 15.7 0.2 0.054 14.0 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) Sigma_reg_C PF13791.6 KII69080.1 - 0.053 13.7 1.3 0.075 13.2 1.3 1.4 1 0 0 1 1 1 0 Sigma factor regulator C-terminal DDE_Tnp_IS1595 PF12762.7 KII69081.1 - 0.061 13.3 0.1 0.15 12.1 0.1 1.7 1 1 1 2 2 2 0 ISXO2-like transposase domain HTH_Tnp_Tc3_2 PF01498.18 KII69083.1 - 0.00063 19.9 0.2 0.0013 19.0 0.2 1.6 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc3_1 PF11427.8 KII69083.1 - 0.00079 19.2 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 Tc3 transposase CRT10 PF08728.10 KII69083.1 - 0.043 12.0 1.4 0.041 12.1 1.4 1.0 1 0 0 1 1 1 0 CRT10 YHS PF04945.13 KII69083.1 - 0.22 11.7 1.0 1.3 9.2 0.6 2.0 2 0 0 2 2 2 0 YHS domain zf-H2C2_2 PF13465.6 KII69084.1 - 1.2e-06 28.6 31.6 2.5e-06 27.7 0.6 5.0 6 0 0 6 6 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KII69084.1 - 7.2e-06 26.4 22.3 0.00026 21.6 1.5 5.2 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KII69084.1 - 7.4e-06 26.1 26.6 7e-05 23.1 1.7 5.3 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KII69084.1 - 4.9e-05 23.5 1.8 0.12 12.6 0.2 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding Zn-C2H2_12 PF18112.1 KII69084.1 - 0.00025 21.4 2.1 0.039 14.4 0.3 2.8 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 KII69084.1 - 0.0028 18.0 6.8 0.082 13.2 2.1 3.2 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 KII69084.1 - 0.0055 16.5 0.2 0.19 11.5 0.1 2.5 2 0 0 2 2 2 1 GAGA factor zf-C2H2_6 PF13912.6 KII69084.1 - 0.0076 16.2 8.8 0.16 12.0 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_9 PF16293.5 KII69084.1 - 0.014 15.2 5.0 0.32 10.9 0.4 3.3 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-met PF12874.7 KII69084.1 - 0.015 15.7 10.9 0.13 12.7 0.6 3.3 4 0 0 4 4 3 0 Zinc-finger of C2H2 type Rad50_zn_hook PF04423.14 KII69084.1 - 0.015 15.1 1.8 7 6.6 0.1 3.1 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-Di19 PF05605.12 KII69084.1 - 0.038 14.3 12.0 0.16 12.3 0.8 3.0 3 0 0 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C3HC4_3 PF13920.6 KII69084.1 - 0.14 12.0 3.1 7.8 6.5 0.2 3.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Elf1 PF05129.13 KII69084.1 - 0.15 12.1 3.6 16 5.7 0.2 3.6 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like RNF220 PF15926.5 KII69084.1 - 0.21 11.2 0.4 2.1 7.9 0.1 2.1 1 1 1 2 2 2 0 E3 ubiquitin-protein ligase RNF220 zf-MIZ PF02891.20 KII69084.1 - 0.36 10.6 4.6 8.6 6.2 0.1 3.3 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger zf-AN1 PF01428.16 KII69084.1 - 0.42 10.8 7.7 4.2 7.6 0.2 3.1 2 1 0 2 2 2 0 AN1-like Zinc finger DUF629 PF04780.12 KII69084.1 - 0.49 8.9 2.8 6.4 5.2 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Baculo_IE-1 PF05290.11 KII69084.1 - 0.51 10.3 4.7 0.47 10.4 2.7 1.9 2 1 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) DUF2225 PF09986.9 KII69084.1 - 0.66 9.7 3.5 13 5.4 0.7 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_11 PF16622.5 KII69084.1 - 1.1 9.1 14.8 0.76 9.6 0.5 3.6 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C3HC PF07967.13 KII69084.1 - 1.9 8.6 4.3 4.1 7.4 1.7 2.6 1 1 1 2 2 2 0 C3HC zinc finger-like zf-C2HC_2 PF13913.6 KII69084.1 - 3.1 7.8 6.3 2 8.4 0.3 3.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zinc_ribbon_9 PF14369.6 KII69084.1 - 3.4 8.0 7.8 8.2 6.8 0.0 3.7 4 0 0 4 4 3 0 zinc-ribbon zf_UBZ PF18439.1 KII69084.1 - 4.8 6.9 9.4 1.5 8.5 0.2 3.3 4 0 0 4 4 3 0 Ubiquitin-Binding Zinc Finger MapZ_EC1 PF18041.1 KII69085.1 - 1.2 9.4 8.2 0.11 12.8 3.0 1.8 2 0 0 2 2 2 0 MapZ extracellular domain 1 G-alpha PF00503.20 KII69086.1 - 2.1e-78 264.0 0.3 3.1e-78 263.4 0.3 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KII69086.1 - 9.3e-15 54.5 0.4 2.2e-11 43.5 0.0 2.9 3 1 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KII69086.1 - 0.00025 20.5 1.3 0.075 12.4 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 KII69086.1 - 0.00031 20.9 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 KII69086.1 - 0.025 15.0 0.0 0.061 13.7 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain Med5 PF08689.10 KII69086.1 - 0.027 12.3 0.2 0.032 12.0 0.2 1.0 1 0 0 1 1 1 0 Mediator complex subunit Med5 AAA_29 PF13555.6 KII69086.1 - 0.048 13.4 0.0 0.094 12.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3666 PF12408.8 KII69086.1 - 0.069 12.4 0.5 0.41 9.9 0.2 2.3 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase DUF87 PF01935.17 KII69086.1 - 0.086 12.9 1.0 0.26 11.4 0.2 1.9 1 1 0 2 2 2 0 Helicase HerA, central domain UPF0052 PF01933.18 KII69086.1 - 0.096 11.9 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0052 GTP_EFTU PF00009.27 KII69086.1 - 0.096 12.2 0.0 0.46 10.0 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain UPF0147 PF03685.13 KII69086.1 - 0.12 12.5 0.4 0.68 10.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0147) DUF3644 PF12358.8 KII69086.1 - 0.15 12.6 0.1 0.43 11.1 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3644) ABC_tran PF00005.27 KII69086.1 - 0.16 12.5 0.0 0.26 11.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Ribul_P_3_epim PF00834.19 KII69088.1 - 1.2e-35 122.7 0.3 1.4e-35 122.5 0.3 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 KII69088.1 - 0.0033 17.2 0.0 0.0047 16.7 0.0 1.3 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 KII69088.1 - 0.02 14.4 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein IGPS PF00218.21 KII69088.1 - 0.09 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase OMPdecase PF00215.24 KII69088.1 - 0.098 12.2 0.1 0.22 11.1 0.0 1.5 1 1 1 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Choline_kinase PF01633.20 KII69091.1 - 3.5e-22 79.1 0.1 9.9e-22 77.6 0.1 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 KII69091.1 - 6.8e-08 32.7 0.0 1.2e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF5416 PF17437.2 KII69091.1 - 0.0017 18.2 0.2 0.0037 17.1 0.2 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5416) DUF3112 PF11309.8 KII69092.1 - 0.55 9.6 8.4 0.36 10.3 7.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) TRIQK PF15168.6 KII69092.1 - 1.5 8.7 9.3 0.21 11.5 2.2 2.3 1 1 1 2 2 2 0 Triple QxxK/R motif-containing protein family UDPGP PF01704.18 KII69093.1 - 3.8e-29 101.6 0.0 4.3e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 KII69093.1 - 0.062 13.7 0.1 0.1 13.0 0.1 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain PRP3 PF08572.10 KII69094.1 - 1.2e-68 231.2 5.3 1.2e-68 231.2 5.3 1.8 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 KII69094.1 - 8.7e-29 100.5 0.5 3.7e-28 98.5 0.5 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) CAF1 PF04857.20 KII69095.1 - 4.8e-16 58.8 0.5 5.3e-16 58.7 0.5 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease Hemocyanin_M PF00372.19 KII69095.1 - 0.027 13.6 0.3 0.059 12.5 0.3 1.5 1 0 0 1 1 1 0 Hemocyanin, copper containing domain HTH_Tnp_IS630 PF01710.16 KII69095.1 - 0.11 12.5 2.5 0.22 11.5 2.5 1.5 1 0 0 1 1 1 0 Transposase s48_45 PF07422.13 KII69095.1 - 0.23 12.1 5.3 0.079 13.5 2.3 1.7 2 0 0 2 2 2 0 Sexual stage antigen s48/45 domain Hexapep PF00132.24 KII69096.1 - 4.9e-06 26.1 26.0 0.0063 16.2 6.5 3.7 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) DUF5601 PF18151.1 KII69096.1 - 0.00021 21.5 0.6 0.00069 19.9 0.6 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) Fucokinase PF07959.12 KII69096.1 - 0.0013 17.7 5.1 0.0049 15.9 5.2 1.7 1 1 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 KII69096.1 - 0.034 13.9 27.1 0.65 9.8 11.4 4.0 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase NTP_transferase PF00483.23 KII69096.1 - 0.059 12.9 0.1 0.2 11.2 0.0 1.9 3 0 0 3 3 3 0 Nucleotidyl transferase YozE_SAM_like PF06855.12 KII69096.1 - 0.087 13.0 0.1 0.28 11.4 0.1 1.9 1 0 0 1 1 1 0 YozE SAM-like fold DUF4954 PF16314.5 KII69096.1 - 0.31 9.1 7.8 0.36 8.9 6.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4954) GTP_EFTU PF00009.27 KII69097.1 - 8.9e-32 110.2 0.1 1.6e-31 109.4 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KII69097.1 - 9.4e-07 29.1 0.2 9.4e-07 29.1 0.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KII69097.1 - 1.2e-06 28.6 0.0 2.7e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KII69097.1 - 3.7e-06 26.5 0.5 1.3e-05 24.8 0.5 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RIBIOP_C PF04950.12 KII69097.1 - 0.0013 18.2 0.4 0.0028 17.1 0.4 1.6 1 1 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal PduV-EutP PF10662.9 KII69097.1 - 0.0059 16.4 0.1 0.74 9.6 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 KII69097.1 - 0.0085 15.9 0.9 2.6 7.8 0.2 2.8 2 1 0 2 2 2 2 Conserved hypothetical ATP binding protein GTP_EFTU_D4 PF14578.6 KII69097.1 - 0.016 15.1 0.6 0.097 12.6 0.2 2.5 2 0 0 2 2 2 0 Elongation factor Tu domain 4 cobW PF02492.19 KII69097.1 - 0.097 12.2 1.6 0.7 9.5 0.3 2.7 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain WD40 PF00400.32 KII69099.1 - 1.8e-15 57.0 7.8 1.4e-07 32.1 0.6 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII69099.1 - 1.2e-08 35.2 0.0 0.0015 18.8 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 KII69099.1 - 0.06 12.3 0.0 5.8 5.7 0.0 2.0 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain CTP_transf_like PF01467.26 KII69100.1 - 8.5e-12 45.5 0.0 9.9e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like RL11D PF11088.8 KII69101.1 - 0.036 14.3 0.1 0.51 10.7 0.0 2.1 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 V-ATPase_G PF03179.15 KII69103.1 - 7.2e-22 77.9 11.7 8e-22 77.8 11.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit SopE_GEF PF07487.13 KII69103.1 - 0.0046 17.1 0.5 0.0067 16.5 0.5 1.3 1 0 0 1 1 1 1 SopE GEF domain V-ATPase_G_2 PF16999.5 KII69103.1 - 0.0086 16.5 11.6 0.011 16.2 11.6 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Peptidase_S46 PF10459.9 KII69103.1 - 0.019 13.6 3.2 0.021 13.5 3.2 1.0 1 0 0 1 1 1 0 Peptidase S46 ParBc PF02195.18 KII69103.1 - 0.019 15.2 2.6 0.12 12.6 0.3 2.1 1 1 1 2 2 2 0 ParB-like nuclease domain DUF4088 PF13317.6 KII69103.1 - 0.035 13.7 0.9 0.041 13.4 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) GrpE PF01025.19 KII69103.1 - 0.048 13.3 8.1 0.063 12.9 8.1 1.3 1 0 0 1 1 1 0 GrpE tRNA-synt_1c PF00749.21 KII69103.1 - 0.055 12.4 2.3 0.068 12.0 2.3 1.3 1 1 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain PIN_8 PF18476.1 KII69103.1 - 0.2 11.5 5.4 0.24 11.3 5.4 1.1 1 0 0 1 1 1 0 PIN like domain DUF883 PF05957.13 KII69103.1 - 0.24 12.0 9.5 1.4 9.5 5.3 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4047 PF13256.6 KII69103.1 - 0.57 10.4 6.2 1.1 9.4 6.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) CemA PF03040.14 KII69103.1 - 0.63 9.9 3.3 0.71 9.8 3.3 1.1 1 0 0 1 1 1 0 CemA family DUF1664 PF07889.12 KII69103.1 - 0.69 10.0 4.6 1.6 8.8 4.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) YtxH PF12732.7 KII69103.1 - 1.1 9.8 5.4 4.2 8.0 5.4 1.9 1 1 0 1 1 1 0 YtxH-like protein ATP-synt_B PF00430.18 KII69103.1 - 2.5 8.2 17.2 1.7 8.7 5.6 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) TMPIT PF07851.13 KII69103.1 - 2.6 7.2 4.7 3 7.0 4.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein eIF-5_eIF-2B PF01873.17 KII69104.1 - 5.1e-34 116.7 0.6 6.1e-34 116.4 0.6 1.0 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 KII69104.1 - 0.0036 16.8 0.3 0.0057 16.1 0.3 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Lar_restr_allev PF14354.6 KII69104.1 - 0.032 14.6 0.3 0.059 13.8 0.3 1.5 1 1 0 1 1 1 0 Restriction alleviation protein Lar Elf1 PF05129.13 KII69104.1 - 0.034 14.2 1.2 0.054 13.5 1.2 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 KII69104.1 - 0.061 13.3 1.2 2.6 8.0 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 KII69104.1 - 0.064 13.2 1.3 0.19 11.7 1.3 1.7 1 1 0 1 1 1 0 PhnA Zinc-Ribbon Ribo_biogen_C PF04034.13 KII69106.1 - 4.9e-39 133.0 0.0 6.5e-39 132.6 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal Tubulin PF00091.25 KII69107.1 - 8.1e-62 208.9 0.1 2.2e-61 207.5 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KII69107.1 - 1.1e-33 116.1 0.4 2.2e-33 115.1 0.4 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KII69107.1 - 5.6e-06 26.7 0.0 9.9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 KII69107.1 - 0.00012 21.8 0.0 0.00026 20.7 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain PH_RBD PF12068.8 KII69107.1 - 0.11 11.9 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Rab-binding domain (RBD) PGM_PMM_II PF02879.16 KII69107.1 - 0.16 12.6 0.0 4.8 7.9 0.0 3.0 3 1 0 3 3 3 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II CagS PF16707.5 KII69108.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 0 Cag pathogenicity island protein S of Helicobacter pylori DUF4422 PF14393.6 KII69108.1 - 0.024 14.5 0.2 0.028 14.3 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) DUF5387 PF17361.2 KII69108.1 - 0.065 12.9 0.5 0.079 12.6 0.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5387) RRM_1 PF00076.22 KII69110.1 - 0.0015 18.4 0.0 0.0028 17.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSB_motif PF16294.5 KII69110.1 - 0.016 15.5 0.0 0.016 15.5 0.0 2.8 2 1 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif AT_hook PF02178.19 KII69110.1 - 0.072 13.0 8.2 0.26 11.3 8.2 2.1 1 0 0 1 1 1 0 AT hook motif Asp-B-Hydro_N PF05279.11 KII69110.1 - 8.6 6.4 12.8 12 5.9 12.8 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 KII69110.1 - 9.2 4.9 4.9 10 4.7 4.9 1.1 1 0 0 1 1 1 0 Presenilin DUF155 PF02582.14 KII69111.1 - 2.7e-18 66.7 0.1 3.4e-18 66.3 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Sirohm_synth_C PF14823.6 KII69111.1 - 0.095 12.3 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal Evr1_Alr PF04777.13 KII69112.1 - 1.5e-26 92.8 0.1 2.2e-26 92.2 0.1 1.2 1 0 0 1 1 1 1 Erv1 / Alr family zf-H2C2_2 PF13465.6 KII69112.1 - 0.057 13.9 1.2 0.23 12.0 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain LSM PF01423.22 KII69113.1 - 5.6e-17 61.2 0.7 7.6e-17 60.8 0.7 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KII69113.1 - 0.0091 16.1 0.1 0.014 15.6 0.1 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF3247 PF11607.8 KII69113.1 - 0.022 15.0 0.0 0.034 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) Gemin7 PF11095.8 KII69113.1 - 0.028 14.3 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) Terminase_3C PF17288.2 KII69115.1 - 0.097 13.1 0.2 0.11 12.8 0.2 1.1 1 0 0 1 1 1 0 Terminase RNAseH like domain zf-ZPR1 PF03367.13 KII69116.1 - 8.1e-51 172.0 6.8 2e-40 138.2 0.1 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Dehyd-heme_bind PF09098.10 KII69116.1 - 0.01 15.5 0.3 0.031 13.9 0.0 1.9 3 0 0 3 3 3 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding DZR PF12773.7 KII69116.1 - 0.13 12.4 7.9 1.8 8.6 1.3 2.7 2 1 0 2 2 2 0 Double zinc ribbon TIG PF01833.24 KII69116.1 - 0.14 12.2 0.4 0.51 10.5 0.0 2.0 2 0 0 2 2 2 0 IPT/TIG domain UPF0547 PF10571.9 KII69116.1 - 0.16 12.1 2.0 5.3 7.2 0.1 2.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zinc-ribbons_6 PF07191.12 KII69116.1 - 0.18 11.8 8.0 0.079 13.0 1.2 2.7 2 1 0 2 2 2 0 zinc-ribbons Churchill PF06573.11 KII69116.1 - 0.24 11.7 4.7 0.97 9.8 1.2 2.4 2 0 0 2 2 2 0 Churchill protein zf-RRPl_C4 PF17026.5 KII69116.1 - 0.38 10.9 5.7 0.73 10.0 1.2 2.5 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type Cytochrome_C554 PF13435.6 KII69116.1 - 1.5 9.8 7.9 0.84 10.6 2.7 2.4 2 0 0 2 2 2 0 Cytochrome c554 and c-prime zn-ribbon_14 PF16503.5 KII69116.1 - 2.3 7.8 9.4 1.6 8.3 0.6 3.2 3 0 0 3 3 3 0 Zinc-ribbon Zn_Tnp_IS1595 PF12760.7 KII69116.1 - 6.9 6.7 8.2 1.8 8.6 0.2 3.0 2 1 0 2 2 2 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 KII69116.1 - 8.6 6.4 9.9 10 6.1 0.2 3.1 3 1 1 4 4 4 0 Putative transposase DNA-binding domain T6SS_VasE PF05936.12 KII69118.1 - 1.2e-28 100.0 0.0 1.6e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE DotU PF09850.9 KII69118.1 - 3.8e-25 88.8 0.0 5.1e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Type VI secretion system protein DotU DUF3287 PF11690.8 KII69119.1 - 0.14 11.9 0.1 0.16 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) DUF2345 PF10106.9 KII69120.1 - 6e-45 152.8 0.5 6e-45 152.8 0.5 1.9 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2345) T6SS_Vgr PF13296.6 KII69120.1 - 1.7e-33 115.0 2.9 1.7e-33 115.0 2.9 2.1 2 1 0 2 2 2 1 Putative type VI secretion system Rhs element Vgr DUF3540 PF12059.8 KII69120.1 - 0.034 14.0 5.6 1.6 8.5 0.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3540) DSBA PF01323.20 KII69120.1 - 0.078 12.7 0.5 0.12 12.2 0.5 1.3 1 0 0 1 1 1 0 DSBA-like thioredoxin domain DUF3828 PF12883.7 KII69121.1 - 2.6e-09 37.5 0.2 3.3e-09 37.1 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3828) SLT PF01464.20 KII69122.1 - 0.019 14.6 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Transglycosylase SLT domain VCBS PF13517.6 KII69123.1 - 0.023 15.3 0.1 0.11 13.2 0.0 2.0 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PolyA_pol PF01743.20 KII69124.1 - 7.9e-31 107.1 0.1 1.3e-30 106.4 0.1 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 KII69124.1 - 3.8e-09 36.2 0.0 1.2e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 Probable RNA and SrmB- binding site of polymerase A DDE_Tnp_IS1595 PF12762.7 KII69125.1 - 2.2e-09 37.5 0.0 2.9e-09 37.1 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain Lactamase_B PF00753.27 KII69126.1 - 3.5e-07 30.4 0.0 3.7e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KII69126.1 - 4.5e-05 23.1 0.0 4.9e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PDEase_II PF02112.15 KII69126.1 - 0.013 14.6 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II DUF5617 PF18493.1 KII69126.1 - 0.015 15.4 0.4 0.024 14.7 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) TFIID_30kDa PF03540.13 KII69127.1 - 3.7e-16 58.8 0.0 7.4e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Ribosomal_60s PF00428.19 KII69127.1 - 0.073 13.7 0.1 0.33 11.6 0.0 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein PilO PF04350.13 KII69128.1 - 0.026 14.7 0.0 0.031 14.4 0.0 1.2 1 0 0 1 1 1 0 Pilus assembly protein, PilO RRM_1 PF00076.22 KII69132.1 - 4.4e-16 58.4 0.0 8.9e-16 57.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII69132.1 - 0.0024 18.0 0.0 0.0074 16.4 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif Nup35_RRM PF05172.13 KII69132.1 - 0.056 13.4 0.2 0.29 11.1 0.0 2.3 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif AAA_31 PF13614.6 KII69133.1 - 4.8e-29 101.5 0.0 7.4e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 KII69133.1 - 1.6e-17 63.7 0.0 2.2e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MerR PF00376.23 KII69133.1 - 6.7e-05 22.6 0.0 0.00015 21.4 0.0 1.6 1 0 0 1 1 1 1 MerR family regulatory protein ParA PF10609.9 KII69133.1 - 8.9e-05 22.0 1.0 0.0034 16.9 0.0 2.4 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 KII69133.1 - 0.00047 19.5 0.5 0.069 12.4 0.1 2.2 2 0 0 2 2 2 2 ATPase MipZ ArsA_ATPase PF02374.15 KII69133.1 - 0.00062 19.0 0.6 0.076 12.2 0.1 2.2 2 0 0 2 2 2 2 Anion-transporting ATPase VirC1 PF07015.11 KII69133.1 - 0.01 15.2 0.0 4.6 6.5 0.0 2.3 2 0 0 2 2 2 0 VirC1 protein HTH_31 PF13560.6 KII69133.1 - 0.028 14.7 0.7 0.072 13.4 0.4 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain Phage_Cox PF10743.9 KII69133.1 - 0.069 13.3 0.1 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Regulatory phage protein cox MerR_1 PF13411.6 KII69133.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.7 1 1 0 1 1 1 0 MerR HTH family regulatory protein SoPB_HTH PF18090.1 KII69134.1 - 1.8e-39 133.7 0.1 3.7e-39 132.7 0.1 1.5 1 0 0 1 1 1 1 Centromere-binding protein HTH domain ParBc PF02195.18 KII69134.1 - 2.4e-10 40.6 0.0 5.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 ParB-like nuclease domain Lysis_col PF02402.16 KII69135.1 - 0.73 9.6 0.1 0.73 9.6 0.1 4.0 3 2 2 5 5 5 0 Lysis protein Sec1 PF00995.23 KII69136.1 - 1e-78 266.0 13.4 1.2e-78 265.9 13.4 1.0 1 0 0 1 1 1 1 Sec1 family HRI1 PF16815.5 KII69136.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein HRI1 DnaJ PF00226.31 KII69137.1 - 1.2e-18 67.0 3.1 1.2e-18 67.0 3.1 2.1 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 KII69137.1 - 2.9e-10 39.5 0.4 0.001 18.8 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII69137.1 - 2e-07 30.6 0.1 0.0069 16.4 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KII69137.1 - 1.2e-05 25.7 2.4 0.00081 19.9 0.0 4.0 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII69137.1 - 3.5e-05 23.7 0.7 0.039 14.2 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KII69137.1 - 7.2e-05 22.8 3.3 0.42 10.7 0.0 4.2 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 KII69137.1 - 0.00074 19.6 0.0 0.0018 18.4 0.0 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KII69137.1 - 0.00094 19.8 0.0 0.31 12.0 0.0 3.7 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_21 PF09976.9 KII69137.1 - 0.0012 18.6 1.8 0.019 14.7 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 KII69137.1 - 0.0015 18.8 0.5 0.025 14.9 0.1 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KII69137.1 - 0.002 18.3 0.9 0.002 18.3 0.9 2.3 2 1 0 3 3 2 1 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 KII69137.1 - 0.0026 16.8 6.1 0.0093 14.9 0.1 2.2 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 DUF515 PF04415.12 KII69137.1 - 0.0091 14.4 1.4 0.012 14.0 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF515) FlbT PF07378.11 KII69137.1 - 0.062 13.4 2.8 0.073 13.2 0.2 2.3 3 0 0 3 3 3 0 Flagellar protein FlbT TPR_17 PF13431.6 KII69137.1 - 0.07 13.5 0.1 8.4 7.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KII69137.1 - 0.17 12.6 0.5 8.4 7.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Lipoprotein_7 PF01540.16 KII69137.1 - 0.32 10.2 4.3 0.09 12.1 1.4 1.5 2 0 0 2 2 2 0 Adhesin lipoprotein TPR_17 PF13431.6 KII69138.1 - 3.7e-12 45.7 3.4 1.4e-05 25.2 0.1 2.9 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KII69138.1 - 1.3e-10 40.7 3.5 3.7e-06 26.5 0.3 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII69138.1 - 1.6e-09 37.1 3.9 0.00014 21.7 0.1 3.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KII69138.1 - 3.3e-09 37.3 0.0 0.0055 17.3 0.0 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KII69138.1 - 2.2e-06 27.7 0.2 0.00039 20.5 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII69138.1 - 2.7e-06 27.2 3.5 0.00023 21.1 0.2 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KII69138.1 - 1.9e-05 25.1 0.7 0.00039 20.9 0.1 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KII69138.1 - 0.00012 21.7 2.6 0.027 14.1 0.0 2.8 2 1 1 3 3 3 2 TPR repeat TPR_14 PF13428.6 KII69138.1 - 0.00015 22.3 0.1 0.049 14.5 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KII69138.1 - 0.0011 19.4 2.2 0.8 10.5 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 KII69138.1 - 0.015 15.6 0.0 0.062 13.6 0.0 1.9 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KII69138.1 - 0.077 13.2 0.2 0.18 12.1 0.2 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DDE_Tnp_IS1595 PF12762.7 KII69140.1 - 3.6e-07 30.3 0.0 9.4e-07 29.0 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain ESCRT-II PF05871.12 KII69141.1 - 2.9e-13 50.3 3.0 3.2e-08 33.9 0.1 3.1 2 1 1 3 3 3 2 ESCRT-II complex subunit FANCI_S3 PF14677.6 KII69141.1 - 0.017 14.8 2.3 0.45 10.2 0.0 2.3 2 0 0 2 2 2 0 FANCI solenoid 3 GCHY-1 PF02649.14 KII69141.1 - 0.022 14.3 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Type I GTP cyclohydrolase folE2 Nrap_D5 PF17406.2 KII69142.1 - 1.1e-30 106.5 0.0 2.8e-30 105.2 0.0 1.7 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 KII69142.1 - 1.3e-20 73.7 6.6 2.8e-19 69.4 4.6 2.7 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 KII69142.1 - 7.2e-14 52.2 0.0 1.5e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 KII69142.1 - 0.00026 21.2 0.0 0.0006 20.0 0.0 1.6 1 0 0 1 1 1 1 Nrap protein domain 6 Nrap PF03813.14 KII69142.1 - 0.0058 16.7 1.0 0.053 13.6 0.3 2.8 2 1 0 2 2 2 1 Nrap protein domain 1 Sybindin PF04099.12 KII69143.1 - 0.00019 21.4 0.0 0.00022 21.2 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family ORF_2_N PF18492.1 KII69143.1 - 0.15 12.3 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Open reading frame 2 N-terminal domain S-AdoMet_synt_M PF02772.16 KII69145.1 - 7.2e-41 139.2 0.0 8.6e-41 139.0 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain Yippee-Mis18 PF03226.14 KII69148.1 - 3.3e-20 72.3 0.8 5.8e-20 71.5 0.8 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DM PF00751.18 KII69148.1 - 0.0095 15.8 0.4 0.0095 15.8 0.4 2.2 2 0 0 2 2 2 1 DM DNA binding domain RVT_1 PF00078.27 KII69149.1 - 4e-08 33.0 0.0 7.3e-08 32.2 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2745 PF10922.8 KII69150.1 - 0.026 14.8 0.1 0.063 13.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2745) RTT107_BRCT_5 PF16770.5 KII69150.1 - 0.14 12.0 0.6 4.1 7.3 0.1 2.5 2 1 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Myotub-related PF06602.14 KII69151.1 - 1.6e-29 102.9 1.3 2e-29 102.6 1.3 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain MLVIN_C PF18697.1 KII69153.1 - 0.00011 22.3 0.1 0.00019 21.5 0.1 1.4 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Shugoshin_C PF07557.11 KII69153.1 - 0.03 14.1 0.1 0.059 13.2 0.1 1.5 1 0 0 1 1 1 0 Shugoshin C terminus DnaJ_C PF01556.18 KII69153.1 - 0.047 13.8 0.0 0.063 13.4 0.0 1.2 1 0 0 1 1 1 0 DnaJ C terminal domain RT_RNaseH PF17917.1 KII69156.1 - 0.024 14.9 0.0 0.065 13.5 0.0 1.7 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase Kelch_6 PF13964.6 KII69157.1 - 6.8e-19 67.4 14.2 9.2e-05 22.6 0.3 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII69157.1 - 2.8e-13 49.6 15.9 0.00048 20.1 0.0 6.6 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII69157.1 - 5.2e-12 45.2 17.1 0.00036 20.1 0.0 6.4 6 1 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII69157.1 - 2.4e-11 43.6 10.5 0.017 15.4 0.0 5.9 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII69157.1 - 0.00045 20.1 8.2 3.6 7.7 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 KII69157.1 - 0.0038 17.2 15.0 0.18 11.8 0.4 5.5 6 0 0 6 6 6 1 Kelch motif Ntox25 PF15530.6 KII69157.1 - 0.016 15.4 0.1 1.2 9.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial toxin 25 FBA_3 PF08268.12 KII69157.1 - 0.022 14.7 0.2 0.098 12.6 0.0 2.2 2 1 1 3 3 3 0 F-box associated domain Kelch_6 PF13964.6 KII69158.1 - 4.1e-20 71.3 25.4 1.8e-08 34.3 0.1 7.2 5 3 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII69158.1 - 2.4e-18 65.9 14.4 9.3e-05 22.4 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KII69158.1 - 3.8e-16 58.9 12.9 0.00018 21.7 0.0 7.2 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII69158.1 - 1.2e-13 50.4 25.7 0.0023 17.5 1.4 7.2 7 1 0 7 7 7 5 Kelch motif Kelch_5 PF13854.6 KII69158.1 - 3.2e-07 30.2 16.0 0.0026 17.7 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KII69158.1 - 0.00046 20.1 19.5 0.62 10.1 0.1 6.5 6 2 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII69159.1 - 7.6e-05 22.9 0.0 0.00012 22.2 0.0 1.4 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KII69159.1 - 0.00015 21.9 0.0 0.0011 19.2 0.0 2.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 KII69159.1 - 0.0037 17.2 0.0 0.0074 16.3 0.0 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 KII69159.1 - 0.0052 16.7 0.3 4.8 7.3 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Homeodomain PF00046.29 KII69160.1 - 4.9e-17 61.5 1.3 7.4e-17 60.9 1.3 1.3 1 0 0 1 1 1 1 Homeodomain Ada3 PF10198.9 KII69160.1 - 0.054 13.6 6.6 0.2 11.8 1.4 2.1 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 rve PF00665.26 KII69162.1 - 1.4e-10 41.4 0.0 2.4e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Serpin PF00079.20 KII69163.1 - 4.6e-41 141.4 2.9 5.5e-41 141.1 2.9 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII69164.1 - 5.2e-48 164.2 3.9 5.9e-48 164.0 3.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sortilin_C PF15901.5 KII69166.1 - 2.7e-15 57.1 1.7 4.2e-15 56.5 1.7 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII69166.1 - 3.2e-14 52.6 1.5 1.5e-10 40.5 0.1 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII69166.1 - 0.09 12.8 8.7 0.73 10.1 0.2 3.4 4 0 0 4 4 4 0 BNR/Asp-box repeat Methyltransf_11 PF08241.12 KII69167.1 - 2.1e-10 41.1 0.0 4.8e-10 40.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KII69167.1 - 5.6e-09 36.6 0.0 1.3e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII69167.1 - 1e-05 25.5 0.0 2.1e-05 24.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KII69167.1 - 0.00031 21.4 0.1 0.00095 19.9 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain AdoMet_MTase PF07757.13 KII69167.1 - 0.0016 18.7 0.0 0.0063 16.8 0.0 1.9 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.6 KII69167.1 - 0.0022 17.8 0.0 0.0039 17.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 KII69167.1 - 0.0063 16.1 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW WBS_methylT PF12589.8 KII69167.1 - 0.019 15.7 3.7 0.038 14.8 3.7 1.5 1 1 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_32 PF13679.6 KII69167.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 KII69167.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PDCD2_C PF04194.13 KII69168.1 - 1.2e-18 67.8 15.4 4e-17 62.9 6.3 3.3 2 2 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain DUF3073 PF11273.8 KII69168.1 - 0.19 12.5 0.6 0.45 11.3 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) Abhydrolase_1 PF00561.20 KII69169.1 - 1.3e-17 64.3 0.0 1.5e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KII69169.1 - 1.5e-09 38.8 0.0 1.7e-09 38.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KII69169.1 - 1.2e-08 34.5 0.0 1.5e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 KII69169.1 - 4.7e-08 33.0 0.1 0.0023 17.7 0.1 2.1 1 1 1 2 2 2 2 PGAP1-like protein DUF915 PF06028.11 KII69169.1 - 3.2e-06 26.7 0.0 0.00085 18.7 0.1 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.20 KII69169.1 - 0.0013 18.8 0.0 0.0018 18.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PAF-AH_p_II PF03403.13 KII69169.1 - 0.0038 15.8 0.1 1.7 7.1 0.0 2.1 1 1 1 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase PF07224.11 KII69169.1 - 0.0055 15.8 0.1 0.015 14.4 0.1 1.8 1 1 0 1 1 1 1 Chlorophyllase Lipase_3 PF01764.25 KII69169.1 - 0.0059 16.5 0.0 0.0086 15.9 0.0 1.3 1 1 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 KII69169.1 - 0.0064 16.0 0.1 0.015 14.8 0.1 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 KII69169.1 - 0.0083 16.0 0.0 0.0091 15.9 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Chlorophyllase2 PF12740.7 KII69169.1 - 0.011 14.7 0.1 0.02 13.8 0.1 1.5 1 1 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_3 PF07859.13 KII69169.1 - 0.06 13.2 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_2 PF01674.18 KII69169.1 - 0.066 12.7 0.0 0.13 11.7 0.0 1.5 1 1 0 1 1 1 0 Lipase (class 2) LCAT PF02450.15 KII69169.1 - 0.073 12.2 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Esterase PF00756.20 KII69169.1 - 0.2 11.2 0.0 0.37 10.4 0.0 1.6 1 1 0 1 1 1 0 Putative esterase Nop PF01798.18 KII69170.1 - 3.7e-81 272.0 0.1 3.7e-81 272.0 0.1 1.5 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KII69170.1 - 9.1e-18 64.4 3.6 1e-17 64.3 0.2 2.7 3 0 0 3 3 3 1 NOP5NT (NUC127) domain Vezatin PF12632.7 KII69171.1 - 0.014 14.8 0.2 0.016 14.6 0.2 1.1 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes NTP_transferase PF00483.23 KII69172.1 - 2.8e-09 36.9 0.0 1e-08 35.1 0.0 1.8 1 1 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 KII69172.1 - 0.001 18.7 5.4 0.0029 17.2 5.4 1.8 1 0 0 1 1 1 1 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 KII69172.1 - 0.0051 17.2 0.0 0.011 16.2 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain R2K_2 PF18299.1 KII69173.1 - 0.02 14.7 0.0 0.021 14.7 0.0 1.1 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 PurA PF04845.13 KII69174.1 - 0.00059 19.2 0.2 0.044 13.1 0.0 2.3 2 0 0 2 2 2 2 PurA ssDNA and RNA-binding protein AAA_12 PF13087.6 KII69176.1 - 3.1e-42 144.5 0.0 3.4e-42 144.3 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KII69176.1 - 0.014 15.2 0.0 0.049 13.5 0.0 1.9 2 1 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 KII69177.1 - 4.1e-45 154.6 5.8 4.1e-45 154.6 5.8 1.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KII69177.1 - 1.7e-14 54.0 0.1 1.8e-10 40.9 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KII69177.1 - 2.4e-11 44.1 2.3 1.7e-10 41.4 0.5 2.8 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 KII69177.1 - 8.2e-06 25.9 0.4 8.2e-06 25.9 0.4 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 KII69177.1 - 1e-05 25.3 8.1 0.00016 21.3 1.7 2.9 3 0 0 3 3 3 2 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 KII69177.1 - 9.1e-05 21.9 0.2 0.00018 20.9 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 KII69177.1 - 0.00026 20.9 0.2 0.00076 19.4 0.1 1.8 2 0 0 2 2 2 1 Helicase DEAD PF00270.29 KII69177.1 - 0.00035 20.4 0.8 0.00075 19.3 0.8 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_10 PF12846.7 KII69177.1 - 0.0046 15.9 0.2 0.008 15.1 0.2 1.3 1 0 0 1 1 1 1 AAA-like domain SRP54 PF00448.22 KII69177.1 - 0.0053 16.4 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SMC_N PF02463.19 KII69177.1 - 0.0065 15.9 2.6 0.28 10.6 0.2 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 KII69177.1 - 0.0076 16.7 0.0 0.018 15.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PIF1 PF05970.14 KII69177.1 - 0.0088 15.3 0.3 0.35 10.0 0.0 2.4 2 0 0 2 2 2 1 PIF1-like helicase AAA_34 PF13872.6 KII69177.1 - 0.019 13.9 0.0 0.034 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 T2SSE PF00437.20 KII69177.1 - 0.021 13.9 0.0 0.036 13.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_26 PF13500.6 KII69177.1 - 0.074 12.9 0.5 0.28 11.0 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KII69177.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.7 2 0 0 2 2 1 0 AAA ATPase domain Sec2p PF06428.11 KII69177.1 - 0.32 11.0 3.1 0.26 11.3 0.4 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p RP-C_C PF11800.8 KII69177.1 - 1.6 8.8 4.6 0.58 10.2 1.4 1.8 1 1 1 2 2 2 0 Replication protein C C-terminal region AAA_23 PF13476.6 KII69177.1 - 6 7.3 10.9 0.14 12.7 1.8 2.2 2 0 0 2 2 2 0 AAA domain AAA_12 PF13087.6 KII69180.1 - 3.2e-26 92.2 0.0 3.9e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KII69181.1 - 4e-46 157.9 0.6 6.8e-46 157.2 0.6 1.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KII69181.1 - 1.4e-14 54.3 0.0 2.3e-10 40.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KII69181.1 - 9.6e-12 45.5 0.0 5.5e-11 43.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 KII69181.1 - 9.5e-11 41.7 0.7 5.8e-09 35.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 KII69181.1 - 7e-08 32.7 0.2 3.2e-07 30.5 0.2 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 KII69181.1 - 8.1e-08 32.1 0.0 4e-05 23.3 0.1 2.2 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 KII69181.1 - 5.7e-05 22.5 0.0 0.00016 21.0 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 KII69181.1 - 0.00019 21.4 0.0 0.00048 20.0 0.0 1.7 2 0 0 2 2 2 1 Helicase SMC_N PF02463.19 KII69181.1 - 0.0015 18.0 0.2 0.0025 17.3 0.2 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain PIF1 PF05970.14 KII69181.1 - 0.0036 16.5 0.0 0.2 10.8 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase AAA PF00004.29 KII69181.1 - 0.0058 17.1 0.0 0.011 16.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 KII69181.1 - 0.0071 16.9 0.3 0.012 16.1 0.3 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 KII69181.1 - 0.0075 15.9 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain DEAD PF00270.29 KII69181.1 - 0.0075 16.1 0.1 0.013 15.3 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_10 PF12846.7 KII69181.1 - 0.0086 15.0 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 AAA-like domain T2SSE PF00437.20 KII69181.1 - 0.014 14.5 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_26 PF13500.6 KII69181.1 - 0.03 14.2 0.1 0.048 13.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain YbgS PF13985.6 KII69181.1 - 0.063 13.6 1.8 0.12 12.7 1.8 1.5 1 0 0 1 1 1 0 YbgS-like protein ATPase PF06745.13 KII69181.1 - 0.077 12.3 0.1 0.22 10.9 0.1 1.6 1 1 1 2 2 2 0 KaiC AAA_7 PF12775.7 KII69181.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 KII69181.1 - 0.13 11.7 0.0 0.31 10.5 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 KII69181.1 - 0.13 12.5 0.0 0.31 11.3 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_34 PF13872.6 KII69181.1 - 0.14 11.0 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Mg_chelatase PF01078.21 KII69181.1 - 0.17 11.2 0.0 0.36 10.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 KII69181.1 - 0.2 11.5 1.1 2.3 8.1 0.0 2.4 1 1 2 3 3 3 0 RsgA GTPase Gcd10p PF04189.13 KII69182.1 - 0.53 9.4 4.1 0.87 8.6 4.1 1.4 1 1 0 1 1 1 0 Gcd10p family AAA_12 PF13087.6 KII69183.1 - 9.9e-48 162.4 0.2 2.5e-47 161.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 KII69183.1 - 0.0028 17.5 0.0 0.0051 16.6 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 KII69183.1 - 0.0067 16.2 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase DUF1687 PF07955.11 KII69183.1 - 0.01 16.3 0.4 0.026 15.0 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1687) UvrD_C PF13361.6 KII69183.1 - 0.026 13.9 0.5 0.14 11.5 0.0 2.1 2 1 0 3 3 3 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 KII69184.1 - 9.1e-20 71.5 0.3 9.1e-20 71.5 0.3 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KII69184.1 - 2.6e-10 40.4 0.0 4.4e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KII69184.1 - 1.3e-07 32.1 0.1 3e-07 30.9 0.1 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 KII69184.1 - 3.5e-06 26.5 2.3 4.9e-06 26.0 0.2 2.1 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KII69184.1 - 1e-05 25.6 1.8 4.5e-05 23.5 0.1 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 KII69184.1 - 3.3e-05 23.8 0.1 7.8e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 Helicase AAA_23 PF13476.6 KII69184.1 - 0.00027 21.5 3.7 0.069 13.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain DEAD PF00270.29 KII69184.1 - 0.00036 20.3 1.2 0.00043 20.1 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 KII69184.1 - 0.00061 19.4 2.6 0.0013 18.4 0.2 2.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 KII69184.1 - 0.00075 19.9 0.1 0.0023 18.4 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain ATPase PF06745.13 KII69184.1 - 0.00082 18.8 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 KaiC PhoH PF02562.16 KII69184.1 - 0.00082 18.9 0.1 0.0021 17.6 0.0 1.7 2 0 0 2 2 2 1 PhoH-like protein AAA PF00004.29 KII69184.1 - 0.0011 19.4 0.1 0.0028 18.1 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KII69184.1 - 0.0017 17.5 0.1 0.065 12.3 0.0 2.2 1 1 1 2 2 2 1 Type II/IV secretion system protein Bac_DnaA PF00308.18 KII69184.1 - 0.0031 17.4 1.8 0.036 13.9 0.0 2.3 2 0 0 2 2 2 1 Bacterial dnaA protein SRP54 PF00448.22 KII69184.1 - 0.0033 17.1 0.1 0.0058 16.3 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_26 PF13500.6 KII69184.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 KII69184.1 - 0.011 14.9 0.5 0.046 12.9 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase DnaB_C PF03796.15 KII69184.1 - 0.013 14.8 0.1 0.025 13.9 0.1 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain IstB_IS21 PF01695.17 KII69184.1 - 0.018 14.8 0.1 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 KII69184.1 - 0.029 13.9 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KII69184.1 - 0.03 14.3 1.5 0.035 14.0 0.1 1.8 2 0 0 2 2 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 KII69184.1 - 0.031 13.6 0.0 0.06 12.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KII69184.1 - 0.032 14.6 0.0 0.11 12.9 0.0 2.0 1 0 0 1 1 1 0 RNA helicase SMC_N PF02463.19 KII69184.1 - 0.033 13.6 0.5 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain TIP49 PF06068.13 KII69184.1 - 0.034 13.3 0.2 0.21 10.8 0.1 2.0 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_10 PF12846.7 KII69184.1 - 0.037 12.9 0.1 0.067 12.1 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain NACHT PF05729.12 KII69184.1 - 0.038 13.9 0.0 0.077 12.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 KII69184.1 - 0.042 14.1 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KII69184.1 - 0.049 13.1 0.3 0.17 11.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 KII69184.1 - 0.093 12.7 0.0 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 KII69184.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_12 PF13087.6 KII69185.1 - 1.7e-47 161.7 0.1 2.5e-47 161.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KII69185.1 - 9.9e-22 78.0 0.0 1.4e-21 77.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KII69185.1 - 0.0018 18.1 0.0 0.42 10.3 0.0 2.2 1 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 KII69185.1 - 0.012 15.4 0.0 0.094 12.6 0.0 2.2 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 KII69185.1 - 0.2 11.4 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Peptidase_G2 PF11962.8 KII69186.1 - 0.043 13.2 1.1 0.07 12.5 1.1 1.3 1 0 0 1 1 1 0 Peptidase_G2, IMC autoproteolytic cleavage domain Mago_nashi PF02792.14 KII69186.1 - 5.8 7.0 8.6 3.5 7.7 0.7 2.6 2 1 1 3 3 3 0 Mago nashi protein NDK PF00334.19 KII69187.1 - 0.096 12.7 3.1 7.2 6.6 0.0 3.8 1 1 3 4 4 4 0 Nucleoside diphosphate kinase CagD PF16567.5 KII69187.1 - 0.1 12.4 0.4 5.2 6.8 0.0 3.4 2 2 3 5 5 5 0 Pathogenicity island component CagD GerD PF17898.1 KII69187.1 - 0.48 10.4 7.4 0.84 9.6 0.7 3.3 1 1 3 4 4 4 0 Spore germination GerD central core domain IDEAL PF08858.10 KII69187.1 - 2.4 8.0 17.3 24 4.8 0.2 6.2 6 0 0 6 6 6 0 IDEAL domain ATP-synt_Z PF16594.5 KII69187.1 - 3.4 7.2 9.8 19 4.8 0.1 4.2 4 0 0 4 4 4 0 Putative AtpZ or ATP-synthase-associated WD40 PF00400.32 KII69188.1 - 6.5e-06 26.8 2.2 0.87 10.6 0.8 4.6 4 1 0 4 4 4 2 WD domain, G-beta repeat FixQ PF05545.11 KII69189.1 - 2.4 8.2 4.4 5.3 7.1 4.4 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Hydrolase_6 PF13344.6 KII69192.1 - 2e-22 79.2 0.0 3.1e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF4974 PF16344.5 KII69192.1 - 0.014 15.4 0.5 0.028 14.4 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4974) Galactosyl_T PF01762.21 KII69193.1 - 1e-26 94.0 0.4 1.8e-26 93.2 0.4 1.4 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KII69193.1 - 0.0051 16.3 0.0 0.01 15.3 0.0 1.6 1 1 0 1 1 1 1 Fringe-like WD40 PF00400.32 KII69194.1 - 1.5e-14 54.1 4.5 8e-06 26.5 0.1 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII69194.1 - 0.011 16.0 1.2 6.7 7.1 0.4 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KII69194.1 - 0.014 14.2 0.4 0.029 13.1 0.4 1.5 1 1 0 1 1 1 0 Nup133 N terminal like MFS_1 PF07690.16 KII69195.1 - 1.3e-07 30.9 23.6 1.3e-07 30.9 23.6 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF423 PF04241.15 KII69195.1 - 0.36 11.1 0.0 0.36 11.1 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF423) CUE PF02845.16 KII69196.1 - 2.2e-06 27.2 0.0 3.1e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 CUE domain M3 PF09213.10 KII69197.1 - 0.026 13.2 0.0 0.032 12.9 0.0 1.1 1 0 0 1 1 1 0 M3 DDE_3 PF13358.6 KII69198.1 - 5e-10 39.3 0.1 8.2e-10 38.6 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease DnaA_N PF11638.8 KII69198.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 DnaA N-terminal domain DUF1682 PF07946.14 KII69198.1 - 0.18 11.0 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) ABC2_membrane_3 PF12698.7 KII69201.1 - 0.12 11.4 2.5 0.16 11.1 2.5 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein HAT_KAT11 PF08214.11 KII69208.1 - 9.9e-39 133.6 1.0 9.9e-39 133.6 1.0 2.1 3 0 0 3 3 3 1 Histone acetylation protein DUF902 PF06001.13 KII69208.1 - 3.3e-14 53.1 8.4 3.3e-14 53.1 8.4 2.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.25 KII69208.1 - 1.3e-13 50.8 0.0 4e-13 49.2 0.0 1.9 1 0 0 1 1 1 1 Bromodomain zf-TAZ PF02135.16 KII69208.1 - 8.9e-08 32.5 45.4 9.1e-07 29.3 17.5 4.3 4 0 0 4 4 4 2 TAZ zinc finger PHD_2 PF13831.6 KII69208.1 - 0.00032 20.2 3.1 0.00032 20.2 3.1 4.1 5 0 0 5 5 5 1 PHD-finger Presenilin PF01080.17 KII69210.1 - 5.6 5.6 9.0 7.1 5.3 9.0 1.2 1 0 0 1 1 1 0 Presenilin DDE_3 PF13358.6 KII69212.1 - 2.4e-19 69.6 0.0 2.8e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Colicin_Pyocin PF01320.18 KII69212.1 - 0.0046 17.0 0.0 0.0069 16.5 0.0 1.4 1 0 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein DUF2024 PF09630.10 KII69212.1 - 0.012 15.5 0.1 0.026 14.4 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) DDE_1 PF03184.19 KII69212.1 - 0.033 13.9 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.7 KII69215.1 - 0.034 14.1 3.0 1.9 8.5 0.4 2.2 1 1 1 2 2 2 0 ISXO2-like transposase domain IFT81_CH PF18383.1 KII69216.1 - 0.0014 18.9 0.7 0.0086 16.3 0.3 2.7 2 0 0 2 2 2 1 Intraflagellar transport 81 calponin homology domain DUF1635 PF07795.11 KII69216.1 - 0.47 10.3 2.7 0.89 9.4 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) zf-RING_13 PF17977.1 KII69222.1 - 0.12 12.5 2.4 0.28 11.3 0.3 2.6 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Cobl PF09469.10 KII69227.1 - 0.019 15.2 0.1 0.036 14.3 0.1 1.4 1 0 0 1 1 1 0 Cordon-bleu ubiquitin-like domain DUF3987 PF13148.6 KII69228.1 - 1.7e-71 241.2 0.2 2e-71 240.9 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) SicP-binding PF09119.10 KII69229.1 - 0.09 12.8 0.1 0.28 11.2 0.0 1.8 2 0 0 2 2 2 0 SicP binding Kelch_6 PF13964.6 KII69231.1 - 0.00024 21.3 9.2 0.033 14.5 2.3 3.7 3 2 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII69231.1 - 0.00077 19.7 0.9 0.037 14.3 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII69231.1 - 0.0016 18.0 1.6 0.0016 18.0 1.6 3.5 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 KII69231.1 - 0.005 16.8 1.0 0.005 16.8 1.0 2.4 3 0 0 3 3 3 1 Kelch motif MULE PF10551.9 KII69232.1 - 0.00039 20.8 0.0 0.00057 20.3 0.0 1.3 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.18 KII69232.1 - 0.18 10.6 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 Transposase, Mutator family RVP PF00077.20 KII69233.1 - 0.011 16.0 0.0 0.031 14.6 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII69233.1 - 0.012 16.1 0.0 0.086 13.4 0.0 2.4 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease RT_RNaseH_2 PF17919.1 KII69234.1 - 5.9e-06 26.2 0.2 1.6e-05 24.9 0.0 1.8 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII69234.1 - 4.4e-05 23.7 0.3 0.00025 21.3 0.0 2.0 1 1 2 3 3 3 1 RNase H-like domain found in reverse transcriptase zf-AD PF07776.15 KII69234.1 - 0.063 13.5 0.2 0.17 12.2 0.2 1.7 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) Kelch_6 PF13964.6 KII69235.1 - 3.9e-10 39.6 2.7 4.8e-06 26.7 0.1 3.7 3 1 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 KII69235.1 - 7.3e-09 35.1 6.1 6.3e-06 25.7 0.1 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII69235.1 - 5.8e-06 26.2 3.2 0.0052 16.8 0.1 3.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.6 KII69235.1 - 1.1e-05 25.5 0.8 0.0047 17.2 0.1 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 KII69235.1 - 1.6e-05 24.8 0.7 0.057 13.4 0.1 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII69235.1 - 0.00092 19.1 2.5 0.1 12.6 0.1 3.6 3 1 0 3 3 3 1 Kelch motif gag-asp_proteas PF13975.6 KII69236.1 - 0.011 16.2 0.0 0.092 13.3 0.0 2.5 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII69236.1 - 0.018 15.3 0.0 0.056 13.7 0.0 1.8 1 1 0 1 1 1 0 Retroviral aspartyl protease SidE PF12252.8 KII69237.1 - 0.025 12.1 0.1 0.03 11.9 0.1 1.0 1 0 0 1 1 1 0 Dot/Icm substrate protein TrmB PF01978.19 KII69238.1 - 0.0015 18.3 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 KII69238.1 - 0.014 15.2 0.2 0.028 14.2 0.2 1.5 1 0 0 1 1 1 0 Homeodomain-like domain HTH_27 PF13463.6 KII69238.1 - 0.071 13.6 0.3 0.19 12.2 0.1 1.8 2 0 0 2 2 2 0 Winged helix DNA-binding domain DDE_Tnp_IS1595 PF12762.7 KII69242.1 - 9.9e-14 51.6 0.0 1.4e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII69244.1 - 2.6e-14 53.5 0.0 3.6e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Cas_Cas2CT1978 PF09707.10 KII69244.1 - 0.07 13.2 0.0 0.24 11.5 0.0 1.8 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) Ca_hom_mod PF14798.6 KII69244.1 - 0.078 12.1 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Calcium homeostasis modulator SAM_1 PF00536.30 KII69246.1 - 2.1e-09 37.7 0.4 0.00018 21.9 0.0 2.1 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KII69246.1 - 1.3e-07 31.6 1.0 0.0013 18.8 0.1 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 KII69246.1 - 0.043 13.6 0.4 0.56 10.1 0.1 2.2 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) FragX_IP PF05994.11 KII69249.1 - 1.4e-125 420.4 32.2 2.1e-125 419.8 32.2 1.2 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 KII69249.1 - 1.7e-05 24.2 2.1 2.3e-05 23.8 0.1 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1394) DDE_Tnp_IS1595 PF12762.7 KII69251.1 - 1.4e-12 47.9 0.0 2.2e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Agenet PF05641.12 KII69251.1 - 0.1 13.1 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 Agenet domain ADK PF00406.22 KII69255.1 - 1.1e-40 139.2 0.0 1.3e-40 139.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KII69255.1 - 6.6e-26 91.3 0.0 9.5e-26 90.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KII69255.1 - 2.8e-09 37.6 0.0 4.7e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 KII69255.1 - 3.5e-05 23.6 0.1 0.0093 15.7 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.6 KII69255.1 - 4.9e-05 23.5 0.0 0.00017 21.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KII69255.1 - 8.7e-05 21.9 0.0 0.00011 21.5 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin HEAT_2 PF13646.6 KII69256.1 - 2.1e-22 79.3 0.0 2e-09 37.7 0.0 3.0 2 1 1 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 KII69256.1 - 1.2e-21 75.1 0.1 0.00078 19.9 0.0 5.6 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 KII69256.1 - 5.5e-06 26.2 0.0 0.53 10.7 0.0 5.1 6 0 0 6 6 6 2 HEAT repeat Arm PF00514.23 KII69256.1 - 0.05 13.7 0.0 0.78 9.9 0.0 2.6 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KII69256.1 - 0.054 14.0 0.1 4.1 8.0 0.0 3.2 4 0 0 4 4 4 0 HEAT-like repeat PC_rep PF01851.22 KII69256.1 - 0.75 10.4 3.5 47 4.7 0.0 3.7 4 0 0 4 4 4 0 Proteasome/cyclosome repeat EMG1 PF03587.14 KII69257.1 - 4.9e-44 150.3 0.2 7.3e-44 149.8 0.2 1.2 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase TBK1_ULD PF18396.1 KII69257.1 - 0.037 14.0 0.0 1.8 8.6 0.0 2.2 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain PapC_N PF13954.6 KII69258.1 - 4e-33 114.5 0.0 5e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 PapC N-terminal domain Fimbrial PF00419.20 KII69259.1 - 6.3e-06 26.5 0.0 8.1e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Fimbrial protein Fimbrial PF00419.20 KII69260.1 - 1.2e-15 58.1 0.2 1.6e-15 57.7 0.2 1.1 1 0 0 1 1 1 1 Fimbrial protein Sugarporin_N PF11471.8 KII69260.1 - 0.073 13.0 0.4 0.11 12.4 0.4 1.3 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension DDE_3 PF13358.6 KII69263.1 - 1.2e-08 34.8 0.0 2.1e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease TraA PF05513.11 KII69264.1 - 0.00017 21.9 0.2 0.00022 21.6 0.2 1.2 1 0 0 1 1 1 1 TraA DUF5477 PF17571.2 KII69264.1 - 0.11 12.7 0.2 0.29 11.3 0.1 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5477) Response_reg PF00072.24 KII69265.1 - 1.7e-07 31.4 0.1 2.6e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain OKR_DC_1_N PF03709.15 KII69265.1 - 0.0045 17.3 0.1 0.012 15.9 0.1 1.8 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain BetR PF08667.10 KII69265.1 - 0.038 14.0 0.0 0.086 12.9 0.0 1.6 1 1 0 1 1 1 0 BetR domain ABC2_membrane_3 PF12698.7 KII69265.1 - 0.084 12.0 0.1 0.096 11.8 0.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Yippee-Mis18 PF03226.14 KII69265.1 - 0.091 13.0 0.1 0.3 11.3 0.1 1.9 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HATPase_c PF02518.26 KII69266.1 - 2.7e-23 82.6 1.3 2.2e-21 76.5 0.4 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Acetyltransf_1 PF00583.25 KII69266.1 - 5.7e-14 52.4 0.8 1.4e-13 51.0 0.2 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII69266.1 - 4.4e-10 39.6 0.0 1.3e-09 38.1 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII69266.1 - 6.7e-10 39.3 0.1 1.9e-09 37.8 0.1 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KII69266.1 - 0.00015 21.6 0.0 0.0014 18.6 0.0 2.3 2 0 0 2 2 2 1 FR47-like protein HATPase_c_5 PF14501.6 KII69266.1 - 0.00038 20.3 0.4 0.0016 18.3 0.4 2.1 1 0 0 1 1 1 1 GHKL domain Oxidored_molyb PF00174.19 KII69266.1 - 0.00057 19.5 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain HATPase_c_2 PF13581.6 KII69266.1 - 0.0015 18.4 0.0 0.0036 17.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF2524 PF10732.9 KII69266.1 - 0.039 14.2 0.3 0.14 12.5 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) Acetyltransf_9 PF13527.7 KII69266.1 - 0.078 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KII69266.1 - 0.1 13.3 0.1 0.39 11.4 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Tra_M PF05261.11 KII69267.1 - 5e-06 26.5 0.1 5.8e-06 26.3 0.1 1.1 1 0 0 1 1 1 1 TraM protein, DNA-binding vATP-synt_AC39 PF01992.16 KII69268.1 - 3.7e-91 306.1 1.1 4.1e-91 306.0 1.1 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Nab2p_Zf1 PF18260.1 KII69268.1 - 0.37 10.7 3.5 0.85 9.6 0.5 2.2 2 0 0 2 2 2 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 Cation_efflux PF01545.21 KII69269.1 - 6e-16 58.8 16.5 1.5e-15 57.4 16.5 1.6 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 KII69269.1 - 0.038 14.1 1.2 1.3 9.2 0.1 2.4 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter Phage_holin_2_4 PF16082.5 KII69269.1 - 0.04 13.7 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like RNase_3_N PF18497.1 KII69275.1 - 0.043 14.1 0.2 0.074 13.3 0.2 1.4 1 0 0 1 1 1 0 Ribonuclease III N-terminal domain DUF3834 PF12916.7 KII69275.1 - 0.055 12.7 0.1 0.074 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) zf-CCHC PF00098.23 KII69277.1 - 0.00014 21.7 1.3 0.00027 20.9 1.3 1.4 1 0 0 1 1 1 1 Zinc knuckle DDE_Tnp_IS1595 PF12762.7 KII69280.1 - 0.0014 18.6 0.0 0.0043 17.1 0.0 1.7 2 0 0 2 2 2 1 ISXO2-like transposase domain DUF2947 PF11163.8 KII69280.1 - 0.026 14.4 0.3 0.032 14.1 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) Pec_lyase_C PF00544.19 KII69280.1 - 0.1 12.2 0.4 0.14 11.7 0.4 1.2 1 0 0 1 1 1 0 Pectate lyase SNAP PF14938.6 KII69283.1 - 4.3e-06 26.4 0.3 5.5e-06 26.0 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PAX PF00292.18 KII69287.1 - 0.0001 22.2 0.3 0.00047 20.1 0.1 1.9 1 1 1 2 2 2 1 'Paired box' domain HTH_Tnp_IS630 PF01710.16 KII69287.1 - 0.00012 22.1 0.3 0.00015 21.8 0.3 1.1 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 KII69287.1 - 0.0014 19.2 0.1 0.0019 18.8 0.1 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.6 KII69287.1 - 0.0035 16.9 0.5 0.62 9.7 0.0 3.2 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.6 KII69287.1 - 0.0045 16.7 0.1 0.025 14.4 0.0 2.2 2 1 0 3 3 3 1 Homeodomain-like domain HTH_Crp_2 PF13545.6 KII69287.1 - 0.0047 16.9 0.1 0.17 11.9 0.0 2.4 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII69287.1 - 0.0059 16.8 0.4 0.0059 16.8 0.4 1.7 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.6 KII69287.1 - 0.017 14.7 0.1 0.045 13.4 0.0 1.8 1 1 1 2 2 2 0 Winged helix-turn helix HTH_28 PF13518.6 KII69287.1 - 0.025 14.7 0.0 0.36 11.0 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain DDE_3 PF13358.6 KII69290.1 - 0.0013 18.5 0.1 0.0021 17.8 0.0 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease WD40 PF00400.32 KII69291.1 - 0.041 14.8 1.1 13 6.9 0.2 3.8 4 0 0 4 4 4 0 WD domain, G-beta repeat BBS2_Mid PF14783.6 KII69291.1 - 0.13 12.4 2.4 1.2 9.2 0.1 3.2 4 1 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region DDE_Tnp_IS1595 PF12762.7 KII69292.1 - 6e-06 26.3 0.0 7.4e-06 26.0 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain AIF-MLS PF14962.6 KII69295.1 - 3.9 7.4 31.5 0.35 10.8 25.4 2.0 1 1 1 2 2 2 0 Mitochondria Localisation Sequence MIR PF02815.19 KII69297.1 - 4.5e-14 52.7 0.0 2.1e-09 37.5 0.0 2.3 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.11 KII69297.1 - 0.044 13.0 0.1 0.52 9.5 0.0 2.4 2 1 0 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor FtsJ PF01728.19 KII69298.1 - 4e-22 79.2 0.0 6.6e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase COX5A PF02284.16 KII69298.1 - 0.066 13.2 0.2 0.14 12.2 0.2 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va Mic1 PF07035.12 KII69299.1 - 1.3e-09 38.0 0.7 3.6e-09 36.5 0.7 1.7 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Dimer_Tnp_hAT PF05699.14 KII69300.1 - 2.1e-07 30.6 0.1 2.7e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Metallophos PF00149.28 KII69302.1 - 1.8e-40 139.7 0.1 2.3e-40 139.3 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KII69302.1 - 3.4e-22 78.6 2.1 7.2e-22 77.6 2.1 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain DUF316 PF03761.15 KII69302.1 - 0.023 14.3 0.1 0.033 13.8 0.1 1.2 1 0 0 1 1 1 0 Chymotrypsin family Peptidase-S1 RINGv PF12906.7 KII69305.1 - 2.6e-13 49.9 9.6 4.8e-13 49.0 9.6 1.5 1 0 0 1 1 1 1 RING-variant domain SH3_1 PF00018.28 KII69306.1 - 8.5e-16 57.3 0.1 1.5e-15 56.5 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KII69306.1 - 1.9e-15 56.5 0.1 3.4e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KII69306.1 - 7.4e-11 41.6 0.0 1.5e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.23 KII69306.1 - 0.069 13.4 1.9 0.19 12.1 1.5 2.1 1 1 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain EST1 PF10374.9 KII69306.1 - 0.088 13.4 1.6 0.16 12.6 0.8 1.9 1 1 1 2 2 2 0 Telomerase activating protein Est1 Paramyxo_ncap PF00973.19 KII69306.1 - 0.64 8.9 4.0 1 8.2 4.0 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF2408 PF10303.9 KII69306.1 - 2.7 8.6 8.1 11 6.5 7.5 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) MFS_1 PF07690.16 KII69308.1 - 0.00034 19.7 0.2 0.0021 17.1 0.2 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily RT_RNaseH PF17917.1 KII69309.1 - 7.7e-37 125.8 0.1 3.1e-36 123.9 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII69309.1 - 9.2e-34 115.5 0.0 2e-33 114.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII69309.1 - 1.7e-24 86.3 0.0 3.3e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII69309.1 - 1.6e-20 72.9 0.4 4.7e-20 71.5 0.4 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII69309.1 - 0.00035 20.7 0.2 0.0026 17.9 0.0 2.6 2 0 0 2 2 2 1 H2C2 zinc finger MLVIN_C PF18697.1 KII69309.1 - 0.0028 17.7 0.0 0.0092 16.1 0.0 1.8 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII69309.1 - 0.0044 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain GCD14 PF08704.10 KII69310.1 - 3e-11 43.5 0.1 4.1e-11 43.0 0.1 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit APAF1_C PF17908.1 KII69310.1 - 0.0089 16.0 0.2 0.012 15.7 0.2 1.1 1 0 0 1 1 1 1 APAF-1 helical domain GCD14 PF08704.10 KII69311.1 - 1e-12 48.3 0.6 1.1e-12 48.1 0.6 1.0 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit LID PF17916.1 KII69312.1 - 0.14 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 LIM interaction domain (LID) AMP-binding PF00501.28 KII69313.1 - 0.0011 17.7 0.0 0.0013 17.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Orbi_NS3 PF01616.16 KII69313.1 - 0.084 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Orbivirus NS3 ACAS_N PF16177.5 KII69313.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus PSII_Pbs27 PF13326.6 KII69313.1 - 0.15 12.4 0.1 0.21 11.9 0.1 1.2 1 0 0 1 1 1 0 Photosystem II Pbs27 DnaJ PF00226.31 KII69314.1 - 3.6e-21 75.0 0.2 1.2e-20 73.4 0.2 1.9 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 KII69314.1 - 1.6e-06 27.8 0.6 1.1e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Questin_oxidase PF14027.6 KII69314.1 - 0.031 13.8 1.4 0.049 13.2 1.4 1.4 1 1 0 1 1 1 0 Questin oxidase-like Ku_PK_bind PF08785.11 KII69314.1 - 0.075 13.2 4.1 0.24 11.5 4.1 2.0 1 1 0 1 1 1 0 Ku C terminal domain like SNAD4 PF18750.1 KII69314.1 - 0.32 11.1 4.0 0.32 11.1 0.7 2.3 1 1 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 EMC3_TMCO1 PF01956.16 KII69314.1 - 4 7.1 10.6 0.6 9.8 2.6 2.3 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like GIDA_assoc PF13932.6 KII69314.1 - 6.6 6.9 12.2 1.8 8.7 8.4 1.8 2 0 0 2 2 2 0 GidA associated domain SlyX PF04102.12 KII69314.1 - 9.3 7.0 12.0 16 6.2 3.2 3.1 2 1 1 3 3 3 0 SlyX BRCT PF00533.26 KII69315.1 - 2.1e-33 114.5 1.0 3.9e-10 40.0 0.0 5.2 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KII69315.1 - 5.1e-33 112.8 2.1 1.7e-12 47.1 0.1 4.7 4 0 0 4 4 4 4 twin BRCT domain BRCT_2 PF16589.5 KII69315.1 - 2.1e-20 72.9 2.3 2.6e-07 31.0 0.0 4.9 5 0 0 5 5 5 3 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 KII69315.1 - 1.2e-07 31.5 0.0 0.0019 18.0 0.0 4.1 2 1 1 3 3 3 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 KII69315.1 - 1.8e-07 31.3 5.2 0.64 10.3 0.0 4.9 5 0 0 5 5 5 3 DNA ligase 3 BRCT domain rve PF00665.26 KII69316.1 - 9.5e-21 74.2 0.0 1.7e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII69316.1 - 3.5e-15 55.9 0.0 6.9e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII69316.1 - 0.11 12.3 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Peptidase_C65 PF10275.9 KII69317.1 - 1.5e-05 24.6 0.1 2.4e-05 23.9 0.1 1.4 1 1 0 1 1 1 1 Peptidase C65 Otubain Uteroglobin PF01099.17 KII69317.1 - 0.038 14.3 0.1 0.056 13.8 0.1 1.2 1 0 0 1 1 1 0 Uteroglobin family Vps51 PF08700.11 KII69318.1 - 1.5e-12 47.4 1.0 5e-12 45.7 1.0 1.9 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 KII69318.1 - 0.00027 19.8 1.4 0.00053 18.8 1.1 1.6 1 1 0 1 1 1 1 Dor1-like family COG2 PF06148.11 KII69318.1 - 0.0006 19.9 0.5 0.0024 18.0 0.5 2.0 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF1335 PF07056.11 KII69318.1 - 0.013 15.7 0.0 0.034 14.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) COG5 PF10392.9 KII69318.1 - 0.066 13.4 0.5 0.17 12.1 0.5 1.7 1 0 0 1 1 1 0 Golgi transport complex subunit 5 RSS_P20 PF11757.8 KII69318.1 - 0.09 13.2 7.9 23 5.5 5.4 3.1 2 1 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain Baculo_PEP_C PF04513.12 KII69318.1 - 0.13 12.3 2.4 0.37 10.8 2.4 1.8 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.9 KII69318.1 - 0.32 11.0 3.1 0.21 11.6 0.3 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_membrane PF00664.23 KII69319.1 - 2.6e-05 24.0 2.0 3.3e-05 23.7 2.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KII69320.1 - 5.5e-17 62.6 0.0 8.3e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KII69320.1 - 1.3e-07 31.3 0.1 1.5e-07 31.1 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain DEK_C PF08766.11 KII69320.1 - 0.029 14.3 0.1 0.068 13.1 0.1 1.6 1 0 0 1 1 1 0 DEK C terminal domain Pesticin PF16754.5 KII69320.1 - 0.04 13.9 0.0 0.088 12.8 0.0 1.5 2 0 0 2 2 2 0 Bacterial toxin homologue of phage lysozyme, C-term SbcCD_C PF13558.6 KII69320.1 - 0.086 13.1 0.3 1.2 9.4 0.3 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MULE PF10551.9 KII69321.1 - 0.2 12.1 4.0 0.47 10.9 0.8 2.4 1 1 0 2 2 2 0 MULE transposase domain Autophagy_act_C PF03987.15 KII69322.1 - 4.7e-17 62.3 0.2 8.2e-17 61.5 0.2 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 KII69322.1 - 1.3e-14 53.3 0.3 2.6e-14 52.4 0.3 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal DUF5069 PF16798.5 KII69323.1 - 0.095 12.9 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5069) EssA PF10661.9 KII69324.1 - 0.041 13.7 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA T5orf172 PF10544.9 KII69325.1 - 0.078 13.5 0.0 0.083 13.4 0.0 1.2 1 0 0 1 1 1 0 T5orf172 domain DDE_1 PF03184.19 KII69328.1 - 1.3e-15 57.5 0.1 1.4e-15 57.4 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1129 PF06570.11 KII69329.1 - 0.019 14.5 8.0 0.028 13.9 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DDE_3 PF13358.6 KII69333.1 - 5.7e-07 29.4 0.0 8.9e-07 28.8 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Spy1 PF11357.8 KII69334.1 - 0.036 14.3 0.3 0.047 14.0 0.3 1.2 1 0 0 1 1 1 0 Cell cycle regulatory protein KH_7 PF17214.3 KII69335.1 - 0.08 12.9 0.0 5.6 7.0 0.0 2.6 2 0 0 2 2 2 0 KH domain DUF3944 PF13099.6 KII69337.1 - 0.76 9.7 3.6 15 5.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3944) FLYWCH PF04500.16 KII69339.1 - 5.3e-09 36.1 0.1 1.2e-08 35.0 0.1 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain YdjO PF14169.6 KII69339.1 - 0.0012 18.5 0.2 0.0024 17.6 0.2 1.5 1 0 0 1 1 1 1 Cold-inducible protein YdjO AGT PF11440.8 KII69341.1 - 0.015 14.4 0.1 0.027 13.5 0.1 1.4 2 0 0 2 2 2 0 DNA alpha-glucosyltransferase DUF4945 PF16303.5 KII69343.1 - 0.0062 16.5 0.5 0.015 15.3 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4945) Sec7 PF01369.20 KII69343.1 - 0.0098 15.6 2.3 0.011 15.5 0.3 2.0 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 KII69343.1 - 0.01 16.2 1.5 0.2 12.0 0.3 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain PAC3 PF10178.9 KII69345.1 - 0.0033 17.5 0.0 0.0045 17.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 DnaB PF00772.21 KII69345.1 - 0.0078 16.3 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase N terminal domain AAA_12 PF13087.6 KII69346.1 - 2.2e-49 167.8 0.1 2.7e-48 164.3 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 KII69346.1 - 1.2e-46 159.6 0.3 2.2e-46 158.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KII69346.1 - 2.5e-15 56.7 0.0 2.4e-11 43.7 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 KII69346.1 - 7.4e-11 42.6 0.0 2.3e-10 41.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 KII69346.1 - 3.7e-06 26.4 1.2 8.8e-06 25.2 0.1 2.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KII69346.1 - 4.1e-05 23.6 0.8 7.9e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 KII69346.1 - 9e-05 22.1 2.1 0.00032 20.3 0.1 2.5 2 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain ATPase PF06745.13 KII69346.1 - 0.00042 19.7 0.0 0.00077 18.9 0.0 1.4 1 0 0 1 1 1 1 KaiC Helicase_RecD PF05127.14 KII69346.1 - 0.0011 18.8 0.0 0.0026 17.6 0.0 1.6 1 0 0 1 1 1 1 Helicase DEAD PF00270.29 KII69346.1 - 0.003 17.3 0.1 0.0061 16.3 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_26 PF13500.6 KII69346.1 - 0.0049 16.7 0.1 0.01 15.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain PIF1 PF05970.14 KII69346.1 - 0.008 15.4 0.0 0.19 10.8 0.0 2.4 2 0 0 2 2 2 1 PIF1-like helicase PhoH PF02562.16 KII69346.1 - 0.01 15.3 0.0 0.18 11.2 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_10 PF12846.7 KII69346.1 - 0.012 14.6 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.29 KII69346.1 - 0.012 16.0 0.1 0.034 14.6 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KII69346.1 - 0.019 14.9 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain T2SSE PF00437.20 KII69346.1 - 0.023 13.8 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein UvrD_C_2 PF13538.6 KII69346.1 - 0.028 14.3 0.0 0.7 9.8 0.0 2.6 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 KII69346.1 - 0.033 14.6 0.0 0.073 13.5 0.0 1.6 2 0 0 2 2 1 0 AAA ATPase domain SRP54 PF00448.22 KII69346.1 - 0.056 13.1 0.1 0.1 12.2 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain SMC_N PF02463.19 KII69346.1 - 0.093 12.1 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KII69346.1 - 0.11 13.0 1.7 0.37 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KII69346.1 - 0.13 12.0 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein ERCC3_RAD25_C PF16203.5 KII69348.1 - 1.7e-104 348.5 0.2 2.6e-104 347.8 0.2 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 KII69348.1 - 5.1e-16 59.2 0.0 8.7e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KII69348.1 - 9.9e-07 29.1 0.1 2.6e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KII69348.1 - 9.5e-06 24.6 0.0 1.4e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-UBR PF02207.20 KII69349.1 - 2e-15 56.7 20.2 4.9e-15 55.4 20.2 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DUF3725 PF12523.8 KII69352.1 - 0.13 12.6 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) FLYWCH PF04500.16 KII69355.1 - 1.2e-05 25.3 0.9 2.6e-05 24.2 0.9 1.7 1 0 0 1 1 1 1 FLYWCH zinc finger domain Zn_ribbon_recom PF13408.6 KII69355.1 - 0.12 12.9 2.3 0.26 11.8 2.3 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain WRKY PF03106.15 KII69355.1 - 0.27 11.5 3.6 0.55 10.5 3.6 1.5 1 0 0 1 1 1 0 WRKY DNA -binding domain RVP PF00077.20 KII69359.1 - 0.0071 16.6 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII69359.1 - 0.018 15.6 0.0 0.034 14.7 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease COG2 PF06148.11 KII69361.1 - 0.011 15.9 2.9 0.014 15.5 2.9 1.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 CortBP2 PF09727.9 KII69361.1 - 0.011 15.7 2.2 0.012 15.5 2.2 1.1 1 0 0 1 1 1 0 Cortactin-binding protein-2 DUF1043 PF06295.12 KII69361.1 - 0.079 13.0 2.5 0.11 12.5 2.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Baculo_LEF-10 PF07206.11 KII69361.1 - 0.21 11.8 2.3 1.5 9.0 0.1 2.8 1 1 2 3 3 3 0 Baculovirus late expression factor 10 (LEF-10) rve PF00665.26 KII69362.1 - 0.11 12.7 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 Integrase core domain DDE_1 PF03184.19 KII69363.1 - 5.3e-08 32.7 0.0 7.9e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1664 PF07889.12 KII69364.1 - 0.0019 18.2 3.7 0.083 12.9 0.2 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Spc7 PF08317.11 KII69364.1 - 0.0035 16.3 9.0 0.02 13.8 9.1 1.7 1 1 0 1 1 1 1 Spc7 kinetochore protein CdvA PF18822.1 KII69364.1 - 0.0056 16.5 8.3 0.66 9.8 0.6 2.3 1 1 1 2 2 2 2 CdvA-like coiled-coil domain Baculo_PEP_C PF04513.12 KII69364.1 - 0.006 16.6 5.6 0.1 12.7 5.4 2.1 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus MAD PF05557.13 KII69364.1 - 0.0092 14.4 7.3 0.01 14.3 7.3 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein SKA1 PF07160.12 KII69364.1 - 0.011 15.7 6.1 0.013 15.4 6.1 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 TPD52 PF04201.15 KII69364.1 - 0.015 14.9 6.1 0.29 10.7 2.6 2.2 1 1 1 2 2 2 0 Tumour protein D52 family DUF1474 PF07342.11 KII69364.1 - 0.016 15.7 2.3 0.021 15.3 0.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1474) AAA_32 PF13654.6 KII69364.1 - 0.02 13.7 5.9 0.023 13.5 5.9 1.1 1 0 0 1 1 1 0 AAA domain FapA PF03961.13 KII69364.1 - 0.028 13.0 8.8 0.033 12.8 8.8 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A TTKRSYEDQ PF10212.9 KII69364.1 - 0.032 13.2 5.9 1.1 8.2 2.2 2.0 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Pro_CA PF00484.19 KII69364.1 - 0.034 14.5 0.5 0.042 14.1 0.5 1.1 1 0 0 1 1 1 0 Carbonic anhydrase Ada3 PF10198.9 KII69364.1 - 0.037 14.2 3.1 1.4 9.1 2.5 2.2 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 Mis14 PF08641.12 KII69364.1 - 0.054 13.8 4.9 0.07 13.4 4.9 1.3 1 0 0 1 1 1 0 Kinetochore protein Mis14 like Fib_alpha PF08702.10 KII69364.1 - 0.059 13.6 10.0 2.5 8.3 2.7 2.2 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1411 PF07199.11 KII69364.1 - 0.067 12.9 0.8 0.084 12.5 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) DIRP PF06584.13 KII69364.1 - 0.075 13.2 0.6 0.11 12.7 0.6 1.4 1 1 0 1 1 1 0 DIRP OmpH PF03938.14 KII69364.1 - 0.085 13.2 9.4 0.13 12.6 9.3 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) ABC_tran_CTD PF16326.5 KII69364.1 - 0.085 13.1 11.5 0.16 12.2 6.1 2.9 1 1 2 3 3 3 0 ABC transporter C-terminal domain COG5 PF10392.9 KII69364.1 - 0.094 12.9 6.0 1.6 8.9 1.8 2.0 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Apolipoprotein PF01442.18 KII69364.1 - 0.13 12.1 4.6 0.27 11.1 4.6 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain CREPT PF16566.5 KII69364.1 - 0.19 11.9 6.6 2.2 8.5 0.2 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Syntaxin_2 PF14523.6 KII69364.1 - 0.2 12.0 12.3 0.069 13.5 9.4 1.7 2 1 0 2 2 1 0 Syntaxin-like protein DUF1788 PF08747.11 KII69364.1 - 0.22 11.6 5.1 1 9.4 1.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1788) DUF16 PF01519.16 KII69364.1 - 0.26 11.8 7.9 0.34 11.4 7.5 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 Prefoldin_2 PF01920.20 KII69364.1 - 0.3 11.1 12.0 27 4.8 12.0 2.9 1 1 0 1 1 1 0 Prefoldin subunit Mitofilin PF09731.9 KII69364.1 - 0.34 9.7 9.0 0.46 9.3 9.0 1.3 1 1 0 1 1 1 0 Mitochondrial inner membrane protein DUF2408 PF10303.9 KII69364.1 - 0.42 11.2 6.2 1 9.9 6.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DUF4559 PF15112.6 KII69364.1 - 0.45 10.1 6.7 0.55 9.9 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) YojJ PF10372.9 KII69364.1 - 0.84 9.8 7.2 0.5 10.5 1.5 2.5 2 1 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus UPF0449 PF15136.6 KII69364.1 - 1 9.9 7.4 0.96 9.9 0.5 2.2 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 FAM76 PF16046.5 KII69364.1 - 1.3 8.3 5.6 1.4 8.2 5.6 1.1 1 0 0 1 1 1 0 FAM76 protein CHASE6_C PF17150.4 KII69364.1 - 1.3 9.7 7.8 72 4.1 5.1 3.0 1 1 1 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain Enkurin PF13864.6 KII69364.1 - 1.5 9.3 9.2 2.7 8.5 7.0 2.2 1 1 0 2 2 2 0 Calmodulin-binding FliD_N PF02465.18 KII69364.1 - 2.2 9.1 8.0 1.4 9.7 2.9 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Serpin PF00079.20 KII69367.1 - 6.6e-32 111.2 6.4 5.4e-18 65.4 3.1 2.0 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) Serpin PF00079.20 KII69368.1 - 8.8e-47 160.2 3.6 1e-46 159.9 3.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII69369.1 - 6.1e-45 154.1 1.7 8.3e-45 153.7 1.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DuoxA PF10204.9 KII69369.1 - 0.025 13.6 2.5 1.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Dual oxidase maturation factor SNAP PF14938.6 KII69370.1 - 0.0004 19.9 0.2 0.00046 19.7 0.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 KII69370.1 - 0.048 13.5 0.4 15 5.6 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat HAUS2 PF15003.6 KII69371.1 - 0.07 12.9 6.2 0.073 12.8 1.8 2.7 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 2 GP41 PF00517.17 KII69371.1 - 0.19 11.6 2.7 0.49 10.3 2.7 1.7 1 0 0 1 1 1 0 Retroviral envelope protein DUF3450 PF11932.8 KII69371.1 - 5.6 6.2 10.5 0.26 10.6 2.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Tup_N PF08581.10 KII69371.1 - 7.3 7.0 15.5 0.23 11.8 3.5 3.5 3 0 0 3 3 3 0 Tup N-terminal Cortex-I_coil PF09304.10 KII69371.1 - 7.9 6.8 13.4 6.4 7.0 3.2 2.7 1 1 1 2 2 2 0 Cortexillin I, coiled coil DUF4164 PF13747.6 KII69371.1 - 9.9 6.5 9.2 17 5.8 6.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) rve_2 PF13333.6 KII69378.1 - 0.015 15.5 0.1 0.05 13.8 0.0 1.8 1 1 1 2 2 2 0 Integrase core domain FoP_duplication PF13865.6 KII69378.1 - 0.31 11.6 0.1 0.31 11.6 0.1 2.4 2 1 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 PLU-1 PF08429.11 KII69380.1 - 0.00033 19.9 0.2 0.00045 19.5 0.2 1.1 1 0 0 1 1 1 1 PLU-1-like protein EB1_binding PF05937.11 KII69380.1 - 0.009 16.6 1.9 0.012 16.2 1.9 1.4 1 1 0 1 1 1 1 EB-1 Binding Domain Ribosomal_S13 PF00416.22 KII69380.1 - 0.31 11.4 1.5 0.46 10.9 0.9 1.7 2 1 0 2 2 2 0 Ribosomal protein S13/S18 CDC73_C PF05179.14 KII69381.1 - 1e-39 135.8 0.2 1.3e-39 135.5 0.2 1.1 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal DNA_ligase_ZBD PF03119.16 KII69383.1 - 0.11 12.6 0.1 0.16 12.0 0.1 1.3 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain DDE_3 PF13358.6 KII69384.1 - 0.0013 18.5 0.2 0.0017 18.1 0.2 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease EF_TS PF00889.19 KII69387.1 - 1.9e-16 60.3 0.0 5.9e-13 48.9 0.0 2.3 1 1 1 2 2 2 2 Elongation factor TS FliH PF02108.16 KII69387.1 - 0.068 13.2 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Flagellar assembly protein FliH DDE_Tnp_IS1595 PF12762.7 KII69388.1 - 3.3e-17 62.9 0.0 5.6e-17 62.2 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain Kelch_6 PF13964.6 KII69390.1 - 7.3e-06 26.1 6.1 0.0084 16.4 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 KII69390.1 - 0.0017 18.4 9.8 0.072 13.1 0.1 4.4 4 1 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII69390.1 - 0.06 12.9 3.9 2.8 7.6 0.1 4.0 4 1 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 KII69390.1 - 0.1 12.6 5.3 3.2 7.9 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 KII69390.1 - 0.17 12.2 3.4 75 3.8 0.0 4.1 4 1 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 KII69390.1 - 0.59 10.2 2.2 27 4.9 0.0 2.9 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 KII69393.1 - 1.8e-06 28.6 4.3 0.009 16.9 0.0 5.7 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII69393.1 - 2.4e-05 24.6 1.1 4 7.8 0.1 4.4 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain ELYS-bb PF16687.5 KII69393.1 - 0.11 11.1 0.0 3.7 6.1 0.0 2.2 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin Utp21 PF04192.12 KII69394.1 - 1.7e-32 112.8 1.9 2.5e-32 112.3 1.9 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain Rot1 PF10681.9 KII69394.1 - 0.022 14.3 0.1 0.029 13.9 0.1 1.1 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal Syntaxin PF00804.25 KII69395.1 - 0.0035 17.0 2.4 0.0073 16.0 0.6 2.0 1 1 0 2 2 2 1 Syntaxin Topo-VIb_trans PF09239.11 KII69395.1 - 0.12 12.2 0.5 0.27 11.0 0.5 1.5 1 0 0 1 1 1 0 Topoisomerase VI B subunit, transducer HTH_3 PF01381.22 KII69397.1 - 0.00079 19.4 0.2 0.013 15.6 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix HTH_Tnp_Tc5 PF03221.16 KII69397.1 - 0.0038 17.2 0.0 0.006 16.6 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_IclR PF09339.10 KII69397.1 - 0.0042 16.9 0.0 0.0086 15.9 0.0 1.4 2 0 0 2 2 2 1 IclR helix-turn-helix domain CENP-B_N PF04218.13 KII69397.1 - 0.0047 16.5 0.1 0.009 15.6 0.1 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_psq PF05225.16 KII69397.1 - 0.016 14.9 0.1 0.043 13.5 0.0 1.8 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_24 PF13412.6 KII69397.1 - 0.048 13.2 0.0 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_38 PF13936.6 KII69397.1 - 0.051 13.3 0.1 0.59 9.9 0.2 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 KII69397.1 - 0.075 12.9 0.0 0.21 11.4 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_26 PF13443.6 KII69397.1 - 0.12 12.8 0.0 0.3 11.6 0.0 1.6 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Eclosion PF04736.12 KII69398.1 - 0.16 11.7 2.1 1.5 8.6 2.3 2.3 2 1 0 2 2 2 0 Eclosion hormone PEHE PF15275.6 KII69399.1 - 1.3e-07 32.3 0.0 1.3e-07 32.3 0.0 2.9 3 1 0 3 3 3 1 PEHE domain Lon_C PF05362.13 KII69400.1 - 9.1e-23 80.9 0.2 1e-22 80.7 0.2 1.0 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain ChlI PF13541.6 KII69400.1 - 6.7e-06 26.0 0.1 8.9e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase Ribophorin_I PF04597.14 KII69401.1 - 1.1e-85 288.4 8.3 1.8e-85 287.8 8.3 1.3 1 0 0 1 1 1 1 Ribophorin I CDPS PF16715.5 KII69401.1 - 0.0057 16.3 1.0 0.011 15.4 0.6 1.5 1 1 0 1 1 1 1 Cyclodipeptide synthase DUF4407 PF14362.6 KII69401.1 - 0.01 15.2 0.9 0.016 14.6 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4298 PF14131.6 KII69401.1 - 0.047 13.7 2.0 17 5.5 1.5 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) IFT57 PF10498.9 KII69401.1 - 0.058 12.4 9.1 0.095 11.7 9.1 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 KxDL PF10241.9 KII69401.1 - 0.25 11.7 5.8 0.32 11.3 1.4 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein RecG_N PF17190.4 KII69401.1 - 0.32 11.8 3.6 1.3 9.8 1.5 2.9 1 1 1 2 2 2 0 RecG N-terminal helical domain Lipoprotein_2 PF00921.17 KII69401.1 - 7.9 5.9 6.7 1.8 8.0 3.3 1.7 2 0 0 2 2 2 0 Borrelia lipoprotein DIRP PF06584.13 KII69402.1 - 0.033 14.4 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 DIRP IQCJ-SCHIP1 PF15157.6 KII69404.1 - 0.049 13.5 1.5 0.075 12.9 1.0 1.5 1 1 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif WH1 PF00568.23 KII69405.1 - 1.2e-13 51.0 0.4 1.9e-13 50.3 0.3 1.4 1 1 0 1 1 1 1 WH1 domain HTH_33 PF13592.6 KII69406.1 - 1.3e-07 31.1 0.0 3.7e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn helix DDE_3 PF13358.6 KII69406.1 - 1.3e-06 28.3 0.0 0.022 14.5 0.0 2.5 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_32 PF13565.6 KII69406.1 - 0.0011 19.5 0.0 0.0017 18.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII69406.1 - 0.0021 18.3 0.1 0.0039 17.4 0.1 1.5 1 0 0 1 1 1 1 Transposase Pico_P2B PF01552.17 KII69406.1 - 0.077 13.2 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Picornavirus 2B protein MULE PF10551.9 KII69408.1 - 3.1e-12 46.7 0.1 6.1e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 MULE transposase domain Kunitz_BPTI PF00014.23 KII69409.1 - 1.7e-24 85.8 22.7 4.5e-13 49.2 8.1 2.1 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF1132 PF06575.12 KII69410.1 - 0.012 16.0 1.4 0.11 12.9 1.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1132) DUF1232 PF06803.12 KII69411.1 - 1.7e-08 34.1 5.3 1.7e-08 34.1 5.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1232) zf-C3HC4_3 PF13920.6 KII69411.1 - 2.4e-05 24.1 8.2 4.5e-05 23.2 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KII69411.1 - 2.5e-05 24.0 10.0 4.8e-05 23.2 10.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII69411.1 - 0.0001 22.6 10.3 0.0002 21.6 10.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KII69411.1 - 0.00017 21.3 11.4 0.00052 19.8 11.4 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII69411.1 - 0.0036 17.1 9.1 0.0071 16.2 9.1 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-piccolo PF05715.13 KII69411.1 - 0.042 14.0 7.3 1.1 9.4 4.3 2.3 2 0 0 2 2 2 0 Piccolo Zn-finger OppC_N PF12911.7 KII69411.1 - 0.043 13.8 0.1 0.043 13.8 0.1 2.0 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C zf-RING_UBOX PF13445.6 KII69411.1 - 0.045 13.8 5.9 0.053 13.6 3.9 2.1 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 KII69411.1 - 0.08 12.9 10.9 0.33 11.0 10.9 2.1 1 1 0 1 1 1 0 zinc-RING finger domain zf-UDP PF14569.6 KII69411.1 - 0.68 10.1 4.2 1.3 9.2 4.2 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger CTU2 PF10288.9 KII69411.1 - 1.4 9.2 4.8 38 4.6 4.8 2.3 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 RrnaAD PF00398.20 KII69412.1 - 6.1e-33 114.0 0.0 8.9e-33 113.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Metallophos PF00149.28 KII69413.1 - 1.1e-15 58.7 3.2 1.9e-15 57.9 3.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 KII69413.1 - 7.8e-15 55.2 0.0 1.5e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 KII69413.1 - 1.5e-09 38.6 0.0 4.8e-09 37.0 0.0 2.0 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C fn3_PAP PF17808.1 KII69413.1 - 0.048 13.8 0.0 6.3 7.0 0.0 2.5 1 1 1 2 2 2 0 Fn3-like domain from Purple Acid Phosphatase GNT-I PF03071.15 KII69415.1 - 2.1e-14 53.1 0.2 3e-14 52.7 0.2 1.2 1 0 0 1 1 1 1 GNT-I family GNT-I PF03071.15 KII69416.1 - 9e-60 202.6 0.1 1.2e-59 202.3 0.1 1.0 1 0 0 1 1 1 1 GNT-I family Kelch_6 PF13964.6 KII69419.1 - 1.3e-21 76.1 17.6 0.00013 22.1 0.4 5.5 5 1 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 KII69419.1 - 4.6e-14 52.3 8.0 0.015 15.6 0.2 5.9 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.6 KII69419.1 - 5.2e-14 52.0 14.4 0.0014 18.6 0.5 5.5 4 2 1 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII69419.1 - 7.8e-13 47.8 18.2 0.0042 16.6 0.1 5.8 5 1 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KII69419.1 - 5.8e-10 38.7 16.3 0.081 12.9 0.3 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.6 KII69419.1 - 7.7e-07 29.0 18.7 0.002 18.1 0.0 5.2 5 1 0 5 5 5 3 Kelch motif OATP PF03137.20 KII69420.1 - 0.029 12.7 0.0 0.034 12.4 0.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Kinesin PF00225.23 KII69422.1 - 1.6e-109 365.9 0.9 3.2e-109 364.9 0.9 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KII69422.1 - 1.1e-28 100.0 0.2 1.1e-28 100.0 0.2 2.5 2 1 1 3 3 3 1 Microtubule binding UpxZ PF06603.11 KII69422.1 - 0.059 13.6 4.7 4.1 7.7 0.0 3.3 3 0 0 3 3 3 0 UpxZ family of transcription anti-terminator antagonists Dimer_Tnp_Tn5 PF02281.16 KII69422.1 - 0.15 11.8 0.2 0.7 9.6 0.0 2.2 2 0 0 2 2 2 0 Transposase Tn5 dimerisation domain Spc7 PF08317.11 KII69422.1 - 0.38 9.6 24.3 0.71 8.7 13.5 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KII69422.1 - 2.3 8.3 21.5 0.76 9.9 8.0 3.0 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2203 PF09969.9 KII69422.1 - 5.2 7.8 10.6 15 6.4 0.4 3.3 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Cnn_1N PF07989.11 KII69423.1 - 0.081 13.1 43.2 0.07 13.3 2.7 5.3 4 1 1 5 5 5 0 Centrosomin N-terminal motif 1 DUF812 PF05667.11 KII69423.1 - 0.15 10.9 32.7 0.11 11.4 14.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF883 PF05957.13 KII69423.1 - 0.67 10.6 12.1 15 6.3 0.1 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF1664 PF07889.12 KII69423.1 - 3.9 7.5 21.6 1.8 8.6 6.0 3.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.9 KII69423.1 - 5.2 7.3 28.6 0.046 14.0 10.8 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein Fib_alpha PF08702.10 KII69423.1 - 8.4 6.6 33.6 0.35 11.1 8.4 3.3 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4763 PF15960.5 KII69423.1 - 9.7 5.4 33.8 2.7 7.2 17.0 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4763) RPN7 PF10602.9 KII69425.1 - 2.3e-23 82.8 2.6 3.7e-23 82.1 0.6 2.0 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 KII69425.1 - 1.6e-12 47.8 0.3 5.7e-12 46.1 0.3 2.0 1 0 0 1 1 1 1 PCI domain MPS2 PF17060.5 KII69426.1 - 0.064 12.5 0.0 0.085 12.1 0.0 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 Annexin PF00191.20 KII69427.1 - 1.3e-26 92.5 9.9 1.1e-11 44.6 0.3 4.6 4 1 0 4 4 4 4 Annexin DUF4848 PF16140.5 KII69427.1 - 0.026 14.1 0.6 0.041 13.4 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4848) Aminotran_1_2 PF00155.21 KII69429.1 - 3.9e-70 236.8 0.0 4.5e-70 236.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KII69429.1 - 1.6e-06 27.3 0.0 2.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 KII69429.1 - 8.4e-05 21.3 0.0 0.00013 20.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 KII69429.1 - 0.0061 15.9 0.0 0.011 15.1 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase URO-D PF01208.17 KII69430.1 - 2.5e-67 227.5 0.0 3e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) MH1 PF03165.16 KII69431.1 - 2e-36 124.3 0.2 5.8e-36 122.8 0.2 1.7 2 0 0 2 2 2 1 MH1 domain MH2 PF03166.14 KII69431.1 - 2.1e-26 93.3 0.0 3.8e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 MH2 domain SH3_9 PF14604.6 KII69432.1 - 1.2e-17 63.4 0.0 3.7e-17 61.9 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KII69432.1 - 1.8e-14 53.0 0.0 3.6e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KII69432.1 - 1.7e-11 43.6 0.1 3.1e-11 42.8 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain MMACHC PF16690.5 KII69433.1 - 3.2e-13 49.8 0.0 3.4e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type C family A1_Propeptide PF07966.12 KII69433.1 - 0.047 13.6 0.1 0.073 13.0 0.1 1.3 1 0 0 1 1 1 0 A1 Propeptide HTH_23 PF13384.6 KII69434.1 - 6.6e-13 48.1 0.4 1e-08 34.7 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 KII69434.1 - 7.7e-09 34.8 1.5 4.7e-07 29.1 0.1 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 PAX PF00292.18 KII69434.1 - 4.5e-08 33.1 0.2 5.5e-08 32.8 0.2 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 KII69434.1 - 4.4e-07 30.4 0.7 0.00026 21.6 0.0 2.1 1 1 1 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.6 KII69434.1 - 1.8e-06 27.9 0.2 4.9e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 KII69434.1 - 2e-06 28.0 0.1 3.1e-06 27.4 0.1 1.4 1 1 0 1 1 1 1 Transposase HTH_38 PF13936.6 KII69434.1 - 6.7e-06 25.8 1.3 2.1e-05 24.2 0.8 2.0 2 1 0 2 2 2 1 Helix-turn-helix domain DUF1323 PF07037.11 KII69434.1 - 8.1e-06 26.2 0.3 1.5e-05 25.3 0.3 1.6 1 1 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_29 PF13551.6 KII69434.1 - 8.5e-06 25.7 0.1 0.00029 20.8 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn helix Bot1p PF12298.8 KII69434.1 - 9.9e-06 25.8 1.0 1.3e-05 25.5 1.0 1.0 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein CENP-B_N PF04218.13 KII69434.1 - 1.3e-05 24.8 0.9 5.1e-05 22.8 0.1 2.2 2 1 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_33 PF13592.6 KII69434.1 - 1.7e-05 24.4 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII69434.1 - 0.00044 20.4 0.9 0.0019 18.4 0.0 2.2 2 1 0 2 2 2 1 Transposase HTH_3 PF01381.22 KII69434.1 - 0.0014 18.6 0.0 0.023 14.8 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix HTH_24 PF13412.6 KII69434.1 - 0.0044 16.5 2.0 0.49 10.0 0.1 2.9 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_7 PF02796.15 KII69434.1 - 0.0048 16.9 1.7 0.26 11.4 0.3 2.6 2 2 0 2 2 2 1 Helix-turn-helix domain of resolvase TrmB PF01978.19 KII69434.1 - 0.0061 16.4 0.1 0.053 13.4 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MSP1a PF11670.8 KII69434.1 - 0.0085 15.4 0.0 0.014 14.7 0.0 1.3 1 1 0 1 1 1 1 Major surface protein 1a (MSP1a) HTH_Tnp_IS630 PF01710.16 KII69434.1 - 0.0089 16.1 1.5 0.034 14.2 1.5 1.8 1 1 0 1 1 1 1 Transposase TnsD PF15978.5 KII69434.1 - 0.0091 15.0 1.0 0.037 13.0 0.4 1.8 1 1 1 2 2 2 1 Tn7-like transposition protein D LacI PF00356.21 KII69434.1 - 0.013 15.3 1.2 11 5.9 0.0 3.6 3 1 1 4 4 4 0 Bacterial regulatory proteins, lacI family HTH_40 PF14493.6 KII69434.1 - 0.016 15.7 0.0 0.029 14.8 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain SpoIIID PF12116.8 KII69434.1 - 0.019 15.0 1.2 0.34 11.0 1.1 2.3 1 1 0 1 1 1 0 Stage III sporulation protein D YdaS_antitoxin PF15943.5 KII69434.1 - 0.024 14.5 0.2 9.7 6.1 0.1 2.5 3 0 0 3 3 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Tn7_Tnp_TnsA_C PF08721.11 KII69434.1 - 0.029 15.0 0.0 4.7 7.9 0.0 2.4 2 1 0 2 2 2 0 TnsA endonuclease C terminal HTH_Tnp_1_2 PF13022.6 KII69434.1 - 0.031 14.4 0.5 0.1 12.7 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase Arg_repressor PF01316.21 KII69434.1 - 0.038 13.7 1.3 0.065 13.0 0.1 1.9 2 1 0 2 2 2 0 Arginine repressor, DNA binding domain Sigma70_r4_2 PF08281.12 KII69434.1 - 0.039 13.6 0.0 0.34 10.6 0.0 2.2 2 1 0 2 2 2 0 Sigma-70, region 4 HTH_DeoR PF08220.12 KII69434.1 - 0.041 13.6 1.0 0.23 11.2 0.1 2.3 2 1 0 2 2 2 0 DeoR-like helix-turn-helix domain KORA PF16509.5 KII69434.1 - 0.043 14.1 1.2 0.059 13.7 0.3 1.6 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor Sigma70_r4 PF04545.16 KII69434.1 - 0.045 13.3 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_11 PF08279.12 KII69434.1 - 0.067 13.2 1.1 0.17 11.8 0.0 2.2 3 0 0 3 3 2 0 HTH domain HTH_37 PF13744.6 KII69434.1 - 0.091 12.7 0.3 1.8 8.6 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_17 PF12728.7 KII69434.1 - 0.12 12.5 0.0 4.7 7.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain DDE_Tnp_IS1595 PF12762.7 KII69437.1 - 3.3e-05 23.9 1.1 3.3e-05 23.9 1.1 1.6 2 0 0 2 2 2 1 ISXO2-like transposase domain Glyco_hydro_85 PF03644.13 KII69438.1 - 9.8e-39 133.5 0.3 1.2e-38 133.2 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Helicase_C_2 PF13307.6 KII69441.1 - 1.3e-12 48.2 0.3 5.9e-12 46.1 0.1 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 KII69442.1 - 6.2e-43 146.5 3.8 1.1e-42 145.6 3.8 1.4 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 KII69442.1 - 2.1e-26 92.8 0.5 2.2e-24 86.2 0.1 2.4 2 0 0 2 2 2 1 Helical and beta-bridge domain Helicase_C_2 PF13307.6 KII69442.1 - 2.4e-25 89.7 0.0 1.8e-24 86.8 0.0 2.3 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 KII69442.1 - 2.6e-05 24.3 0.2 0.00061 19.8 0.1 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KII69442.1 - 4.8e-05 23.2 0.1 0.0016 18.3 0.1 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 KII69442.1 - 0.0051 16.3 0.0 0.42 10.0 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_11 PF13086.6 KII69442.1 - 0.16 11.7 0.1 0.22 11.3 0.1 1.3 1 1 0 1 1 1 0 AAA domain DUF2283 PF10049.9 KII69443.1 - 0.15 12.3 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2283) Dynactin_p62 PF05502.13 KII69443.1 - 0.25 10.1 0.1 0.3 9.8 0.1 1.0 1 0 0 1 1 1 0 Dynactin p62 family TLE_N PF03920.15 KII69444.1 - 6.1e-20 71.6 1.3 1.2e-19 70.6 1.0 1.6 2 0 0 2 2 2 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.32 KII69444.1 - 7.4e-15 55.1 17.6 0.054 14.4 0.1 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII69444.1 - 5.3e-05 23.4 0.1 0.019 15.2 0.0 3.4 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Tup_N PF08581.10 KII69444.1 - 0.12 12.7 0.2 0.31 11.4 0.2 1.7 1 0 0 1 1 1 0 Tup N-terminal Mss4 PF04421.13 KII69444.1 - 0.58 10.3 2.9 0.32 11.2 0.2 1.9 2 0 0 2 2 2 0 Mss4 protein HemolysinCabind PF00353.19 KII69444.1 - 0.94 9.5 7.0 2.5 8.2 7.0 1.7 1 0 0 1 1 1 0 RTX calcium-binding nonapeptide repeat (4 copies) MULE PF10551.9 KII69445.1 - 1.2e-05 25.6 0.1 1.5e-05 25.4 0.1 1.1 1 0 0 1 1 1 1 MULE transposase domain RtcB PF01139.17 KII69446.1 - 4.1e-26 92.1 0.1 4.8e-26 91.9 0.1 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB DNA_pol_B PF00136.21 KII69447.1 - 1.2e-144 482.5 0.4 1.6e-144 482.0 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KII69447.1 - 3.3e-57 194.1 0.1 4.8e-57 193.6 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 KII69447.1 - 1.9e-06 28.3 10.4 4.5e-06 27.0 10.4 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 KII69447.1 - 0.0037 16.2 0.0 0.0086 15.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral DUF3239 PF11580.8 KII69447.1 - 0.12 12.6 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3239) zinc_ribbon_9 PF14369.6 KII69447.1 - 0.64 10.3 6.5 6 7.2 0.4 2.9 2 0 0 2 2 2 0 zinc-ribbon RRN3 PF05327.11 KII69449.1 - 1.5e-59 202.1 1.6 2.6e-58 198.0 1.6 1.9 1 1 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 YxiJ PF14176.6 KII69449.1 - 0.11 13.0 0.1 0.57 10.7 0.1 2.2 2 0 0 2 2 2 0 YxiJ-like protein Pkinase PF00069.25 KII69450.1 - 0.011 15.2 0.0 0.012 15.0 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Glyco_hydro_63N PF16923.5 KII69453.1 - 0.18 11.9 2.0 0.25 11.4 0.4 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 63 N-terminal domain rve PF00665.26 KII69456.1 - 2.5e-12 47.0 0.0 7.3e-12 45.5 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII69456.1 - 0.0028 17.4 0.0 0.0058 16.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF447 PF04289.12 KII69457.1 - 0.026 14.3 0.0 1.2 8.9 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF447) FtsJ PF01728.19 KII69457.1 - 0.11 12.6 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase fn3_4 PF16794.5 KII69461.1 - 0.038 13.9 0.0 0.068 13.1 0.0 1.4 1 1 0 1 1 1 0 Fibronectin-III type domain zf-RING_9 PF13901.6 KII69462.1 - 0.0016 18.5 1.7 0.003 17.6 1.7 1.5 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon zf-piccolo PF05715.13 KII69462.1 - 0.052 13.7 1.6 0.15 12.2 1.6 1.8 1 0 0 1 1 1 0 Piccolo Zn-finger Zn-ribbon_8 PF09723.10 KII69462.1 - 0.057 13.5 0.5 0.18 11.9 0.5 1.9 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 KII69462.1 - 0.085 12.8 1.6 0.22 11.4 1.6 1.8 1 0 0 1 1 1 0 zinc-ribbon domain zf-H2C2_2 PF13465.6 KII69462.1 - 2 9.0 4.4 1.5 9.4 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger double domain zf-C6H2 PF15801.5 KII69462.1 - 2.5 8.5 8.3 6.4 7.2 0.3 2.9 2 1 1 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding RuvA_N PF01330.21 KII69464.1 - 0.043 13.9 0.0 0.11 12.7 0.0 1.7 1 1 0 1 1 1 0 RuvA N terminal domain Acetyltransf_13 PF13880.6 KII69466.1 - 0.066 13.2 0.1 7.2 6.7 0.0 2.5 1 1 1 2 2 2 0 ESCO1/2 acetyl-transferase Ints3 PF10189.9 KII69467.1 - 0.015 14.6 1.3 0.017 14.4 1.3 1.0 1 0 0 1 1 1 0 Integrator complex subunit 3 DUF3275 PF11679.8 KII69467.1 - 0.2 11.6 0.1 0.26 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) GCP_C_terminal PF04130.13 KII69468.1 - 5.6e-48 164.0 5.0 7e-48 163.7 5.0 1.0 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal ANTH PF07651.16 KII69468.1 - 0.003 16.6 0.1 0.0047 15.9 0.1 1.3 1 0 0 1 1 1 1 ANTH domain TRAPP PF04051.16 KII69468.1 - 0.13 12.0 0.1 0.21 11.3 0.1 1.3 1 0 0 1 1 1 0 Transport protein particle (TRAPP) component GCP_N_terminal PF17681.1 KII69469.1 - 6.2e-15 55.6 0.5 1.9e-10 40.9 0.0 2.2 1 1 1 2 2 2 2 Gamma tubulin complex component N-terminal Hyccin PF09790.9 KII69470.1 - 0.064 12.3 0.8 0.11 11.6 0.8 1.4 1 1 0 1 1 1 0 Hyccin Ank_2 PF12796.7 KII69471.1 - 4.7e-98 321.9 22.4 4.7e-16 59.1 0.0 11.1 4 4 9 13 13 13 13 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII69471.1 - 1.5e-78 258.2 9.1 1.3e-13 51.2 0.1 14.2 5 4 9 16 16 16 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII69471.1 - 1.2e-70 225.0 21.4 2.6e-06 27.3 0.1 22.1 23 0 0 23 23 23 11 Ankyrin repeat Ank PF00023.30 KII69471.1 - 3.7e-61 201.1 22.3 1.3e-05 25.4 0.0 17.3 17 2 1 18 18 18 12 Ankyrin repeat Ank_5 PF13857.6 KII69471.1 - 3.1e-54 180.3 17.0 6.6e-09 35.9 0.2 15.3 6 5 8 15 15 15 12 Ankyrin repeats (many copies) Shigella_OspC PF06128.11 KII69471.1 - 0.0065 16.2 0.1 5.8 6.5 0.0 3.5 3 0 0 3 3 3 2 Shigella flexneri OspC protein Mic1 PF07035.12 KII69471.1 - 0.09 12.5 0.0 14 5.4 0.0 3.4 3 0 0 3 3 3 0 Colon cancer-associated protein Mic1-like KH_1 PF00013.29 KII69472.1 - 1.1e-12 47.6 0.2 2.2e-12 46.6 0.2 1.5 1 0 0 1 1 1 1 KH domain HTH_Tnp_Tc5 PF03221.16 KII69481.1 - 0.0015 18.5 0.0 0.0041 17.1 0.0 1.8 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain PglL_A PF15864.5 KII69482.1 - 0.024 14.4 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein glycosylation ligase SRI PF08236.11 KII69483.1 - 0.00098 19.2 1.8 0.001 19.2 1.1 1.5 1 1 1 2 2 2 1 SRI (Set2 Rpb1 interacting) domain DWNN PF08783.11 KII69485.1 - 5e-24 84.4 0.1 1.2e-23 83.1 0.1 1.7 1 0 0 1 1 1 1 DWNN domain zf-C3HC4_2 PF13923.6 KII69485.1 - 9.4e-06 25.4 8.3 9.4e-06 25.4 8.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.23 KII69485.1 - 1.2e-05 25.1 0.6 2.9e-05 23.9 0.6 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_3 PF13920.6 KII69485.1 - 5.9e-05 22.8 14.2 0.00024 20.9 9.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII69485.1 - 0.00028 20.7 11.9 0.0012 18.6 7.2 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KII69485.1 - 0.00046 20.0 9.7 0.00046 20.0 9.7 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 KII69485.1 - 0.00046 20.3 0.0 0.0013 18.8 0.0 1.8 1 0 0 1 1 1 1 U-box domain zf-RING_2 PF13639.6 KII69485.1 - 0.0026 18.1 8.5 0.0026 18.1 8.5 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KII69485.1 - 0.013 15.4 9.5 0.013 15.4 9.5 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-CCHC_4 PF14392.6 KII69485.1 - 0.024 14.3 1.0 0.08 12.7 1.0 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-RING_6 PF14835.6 KII69485.1 - 0.053 13.4 5.5 0.12 12.3 5.5 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 KII69485.1 - 0.063 13.4 11.3 0.14 12.3 11.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KII69485.1 - 0.2 11.7 8.0 0.92 9.6 8.0 2.2 1 0 0 1 1 1 0 RING-type zinc-finger DDE_3 PF13358.6 KII69486.1 - 1.1e-19 70.6 0.2 1.4e-19 70.3 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RapH_N PF18801.1 KII69486.1 - 0.026 14.6 0.6 1.1 9.3 0.1 2.5 2 1 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal TPR_19 PF14559.6 KII69488.1 - 0.0014 19.1 0.1 0.77 10.3 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII69488.1 - 0.0034 17.4 1.8 3 8.2 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TOM20_plant PF06552.12 KII69488.1 - 0.0068 16.2 0.4 0.78 9.5 0.1 2.5 1 1 1 2 2 2 2 Plant specific mitochondrial import receptor subunit TOM20 TPR_14 PF13428.6 KII69488.1 - 0.039 14.8 0.0 2.3 9.3 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 KII69488.1 - 0.097 13.1 0.2 6.7 7.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII69488.1 - 0.16 11.8 0.9 12 6.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KII69488.1 - 0.29 10.8 2.1 1.1 9.0 0.1 2.7 3 0 0 3 3 3 0 TPR repeat RRM_7 PF16367.5 KII69490.1 - 1.3e-21 76.5 0.0 1.2e-20 73.5 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif RRM_1 PF00076.22 KII69490.1 - 8.4e-12 44.7 0.2 1e-06 28.4 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 KII69490.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 RNA binding domain Myotub-related PF06602.14 KII69491.1 - 1.4e-63 215.0 0.1 1.7e-63 214.7 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain MCM_lid PF17855.1 KII69494.1 - 1e-16 61.1 0.1 1.7e-16 60.4 0.1 1.3 1 0 0 1 1 1 1 MCM AAA-lid domain EF-hand_14 PF17959.1 KII69494.1 - 0.28 11.6 1.7 0.51 10.7 0.2 2.0 2 0 0 2 2 2 0 EF-hand domain zf-C2H2 PF00096.26 KII69496.1 - 9.3e-15 54.2 28.4 1.6e-05 25.1 0.5 4.7 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KII69496.1 - 1.5e-14 53.6 24.5 7.1e-07 29.4 1.6 5.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KII69496.1 - 5.9e-12 45.3 22.8 0.0098 16.7 0.6 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KII69496.1 - 0.007 16.1 17.6 0.77 9.6 2.6 3.7 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KII69496.1 - 0.047 14.0 0.7 0.047 14.0 0.7 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding CCAP PF11105.8 KII69496.1 - 0.14 12.1 7.2 2.3 8.2 0.2 2.6 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a zf-TRAF PF02176.18 KII69496.1 - 0.28 11.9 18.4 1 10.1 5.7 3.7 2 1 2 4 4 4 0 TRAF-type zinc finger zf-C2HE PF16278.5 KII69496.1 - 0.36 11.3 18.9 0.2 12.1 8.3 3.3 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_aberr PF17017.5 KII69496.1 - 0.57 10.3 14.0 1.1 9.3 0.1 3.3 1 1 2 4 4 4 0 Aberrant zinc-finger zf-met PF12874.7 KII69496.1 - 0.64 10.5 0.0 0.64 10.5 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 KII69496.1 - 1.1 9.3 0.1 1.1 9.3 0.1 4.3 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Tsp45I PF06300.12 KII69497.1 - 0.0049 16.4 0.6 0.0083 15.7 0.4 1.4 2 0 0 2 2 2 1 Tsp45I type II restriction enzyme HEAT PF02985.22 KII69500.1 - 4.9e-07 29.4 0.1 1.9 9.0 0.0 3.7 3 0 0 3 3 3 3 HEAT repeat HEAT_2 PF13646.6 KII69500.1 - 1.8e-05 25.1 0.0 0.045 14.1 0.0 2.4 1 1 0 2 2 2 2 HEAT repeats Cnd1 PF12717.7 KII69500.1 - 0.00064 19.8 0.3 0.036 14.1 0.0 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 KII69500.1 - 0.028 14.7 0.4 3.8 7.9 0.1 2.9 2 1 1 3 3 3 0 HEAT repeat associated with sister chromatid cohesion HMG_box PF00505.19 KII69502.1 - 1.7e-19 70.0 2.1 1.7e-19 70.0 2.1 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KII69502.1 - 3.2e-07 30.8 1.3 6.9e-07 29.8 1.3 1.6 1 0 0 1 1 1 1 HMG-box domain DUF4476 PF14771.6 KII69503.1 - 0.0054 17.0 0.0 0.017 15.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) GH97_C PF14509.6 KII69504.1 - 0.11 12.7 0.1 1.7 8.9 0.0 2.0 1 1 1 2 2 2 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation HTH_32 PF13565.6 KII69505.1 - 0.075 13.7 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain CodY PF06018.14 KII69506.1 - 0.021 14.3 0.0 0.025 14.1 0.0 1.1 1 0 0 1 1 1 0 CodY GAF-like domain SNAP PF14938.6 KII69509.1 - 0.00035 20.1 0.1 0.00036 20.0 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NAGLU_C PF12972.7 KII69509.1 - 0.026 14.1 0.1 0.031 13.8 0.1 1.1 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain RRM_1 PF00076.22 KII69510.1 - 4.8e-24 84.0 0.0 8.8e-24 83.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 KII69510.1 - 8e-24 83.9 0.6 1.5e-23 83.1 0.6 1.5 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_7 PF16367.5 KII69510.1 - 0.016 15.3 0.0 0.045 13.9 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif RRM_Rrp7 PF17799.1 KII69510.1 - 0.051 13.4 0.0 0.22 11.3 0.0 2.0 1 1 1 2 2 2 0 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 KII69510.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif DDE_3 PF13358.6 KII69512.1 - 0.023 14.4 0.1 0.043 13.6 0.1 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease FH2 PF02181.23 KII69514.1 - 1.8e-38 132.6 3.3 2.1e-38 132.4 3.3 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain LXG PF04740.12 KII69514.1 - 0.083 12.6 0.1 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 LXG domain of WXG superfamily FliG_M PF14841.6 KII69515.1 - 0.024 14.9 0.1 8 6.8 0.0 2.5 2 0 0 2 2 2 0 FliG middle domain DNA_pol_viral_C PF00336.18 KII69518.1 - 0.016 14.7 0.0 0.083 12.3 0.0 1.9 2 0 0 2 2 2 0 DNA polymerase (viral) C-terminal domain rve_3 PF13683.6 KII69518.1 - 0.033 14.0 0.2 0.089 12.6 0.0 1.8 2 0 0 2 2 2 0 Integrase core domain GP57 PF17594.2 KII69519.1 - 0.053 13.3 0.0 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 Phage Tail fiber assembly helper gene product 57 DDE_3 PF13358.6 KII69520.1 - 0.00061 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII69520.1 - 0.0026 17.4 0.0 0.005 16.5 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII69520.1 - 0.0052 17.0 0.0 0.0081 16.4 0.0 1.4 1 0 0 1 1 1 1 Transposase DUF2520 PF10728.9 KII69520.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2520) RT_RNaseH PF17917.1 KII69522.1 - 5.4e-12 45.9 0.1 8.6e-12 45.3 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII69522.1 - 0.00031 20.7 0.1 0.00051 20.0 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Sortilin-Vps10 PF15902.5 KII69525.1 - 0.0055 15.6 0.1 0.019 13.8 0.1 1.7 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII69525.1 - 0.022 14.7 0.1 7.4 7.0 0.0 3.2 2 0 0 2 2 2 0 BNR/Asp-box repeat Sortilin_C PF15901.5 KII69526.1 - 3.9e-11 43.6 0.6 5.4e-11 43.1 0.6 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PAP_assoc PF03828.19 KII69526.1 - 0.022 15.0 0.2 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 Cid1 family poly A polymerase PELOTA_1 PF15608.6 KII69527.1 - 0.18 11.7 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain Med26 PF08711.11 KII69528.1 - 1.3e-10 41.1 4.0 2.7e-10 40.1 4.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Hydrolase_like PF13242.6 KII69530.1 - 0.00077 19.5 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Tetraspanin PF00335.20 KII69531.1 - 9.5e-15 54.9 7.5 1.1e-14 54.7 7.5 1.0 1 0 0 1 1 1 1 Tetraspanin family RTC_insert PF05189.13 KII69532.1 - 1.2e-11 45.1 0.0 1.5e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 KII69533.1 - 9.1e-21 74.1 0.0 1e-20 73.9 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase zf-RING_2 PF13639.6 KII69534.1 - 0.31 11.4 4.1 0.11 12.8 0.3 2.3 2 0 0 2 2 2 0 Ring finger domain zf-UBR PF02207.20 KII69535.1 - 3.4e-16 59.2 14.3 3.4e-16 59.2 14.3 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) SH3_6 PF12913.7 KII69536.1 - 0.017 14.7 0.0 0.036 13.6 0.0 1.5 1 1 0 1 1 1 0 SH3 domain (SH3b1 type) BNR_2 PF13088.6 KII69536.1 - 0.13 11.6 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 BNR repeat-like domain Adaptin_N PF01602.20 KII69537.1 - 7.3e-13 47.9 0.3 9.4e-13 47.6 0.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region AstA PF04958.12 KII69538.1 - 0.094 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit EF-hand_13 PF17958.1 KII69539.1 - 0.042 13.7 1.1 0.27 11.1 0.4 2.0 2 0 0 2 2 2 0 EF-hand domain MULE PF10551.9 KII69540.1 - 0.056 13.9 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 MULE transposase domain OTU PF02338.19 KII69542.1 - 0.12 12.9 1.0 0.19 12.2 0.2 1.7 2 0 0 2 2 2 0 OTU-like cysteine protease SNAP PF14938.6 KII69545.1 - 0.00058 19.4 0.7 0.00063 19.3 0.7 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF3305 PF11749.8 KII69546.1 - 0.032 14.4 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3305) SMG1 PF15785.5 KII69548.1 - 0.021 13.2 0.1 0.028 12.8 0.1 1.1 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 Peptidase_C50 PF03568.17 KII69548.1 - 0.081 12.0 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Peptidase family C50 SNARE PF05739.19 KII69548.1 - 0.13 12.3 1.6 1 9.4 0.2 2.3 2 0 0 2 2 2 0 SNARE domain HTH_32 PF13565.6 KII69549.1 - 3.5e-09 37.1 0.0 5.4e-08 33.3 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 KII69549.1 - 5.6e-07 29.2 0.0 1.4e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.18 KII69549.1 - 0.012 15.5 0.2 0.026 14.5 0.1 1.5 2 0 0 2 2 2 0 'Paired box' domain HTH_Tnp_Tc3_2 PF01498.18 KII69549.1 - 0.017 15.4 0.1 0.11 12.7 0.1 2.4 2 0 0 2 2 2 0 Transposase HTH_33 PF13592.6 KII69549.1 - 0.019 14.6 0.0 0.038 13.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix TrmB PF01978.19 KII69549.1 - 0.019 14.9 0.0 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_40 PF14493.6 KII69549.1 - 0.024 15.1 0.2 0.077 13.5 0.1 1.9 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.6 KII69549.1 - 0.049 13.8 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 KII69549.1 - 0.077 12.4 0.0 0.2 11.1 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_29 PF13551.6 KII69549.1 - 0.11 12.5 0.0 0.63 10.1 0.0 2.2 2 1 0 2 2 2 0 Winged helix-turn helix HTH_Tnp_1 PF01527.20 KII69549.1 - 0.17 12.2 0.1 0.33 11.3 0.1 1.5 1 0 0 1 1 1 0 Transposase HTH_IclR PF09339.10 KII69549.1 - 0.17 11.7 0.0 0.57 10.0 0.0 1.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain RRM_1 PF00076.22 KII69551.1 - 6.4e-15 54.7 0.0 1.2e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 KII69551.1 - 0.016 15.1 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 RL domain Nup35_RRM_2 PF14605.6 KII69551.1 - 0.019 15.0 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Histone PF00125.24 KII69553.1 - 4.3e-28 98.3 3.1 5.1e-28 98.0 3.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KII69553.1 - 0.0024 17.9 0.1 0.0048 17.0 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PCI PF01399.27 KII69557.1 - 5.6e-12 46.1 3.3 6.1e-12 46.0 0.3 2.6 2 1 0 2 2 2 1 PCI domain ERp29 PF07749.12 KII69557.1 - 0.018 15.9 3.5 0.031 15.2 0.0 3.0 4 0 0 4 4 4 0 Endoplasmic reticulum protein ERp29, C-terminal domain EF-hand_2 PF09068.11 KII69557.1 - 0.064 13.4 0.5 0.21 11.8 0.0 2.1 2 0 0 2 2 2 0 EF hand DUF4790 PF16037.5 KII69559.1 - 0.022 15.2 0.1 0.038 14.5 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4790) Nicastrin PF05450.15 KII69560.1 - 1e-32 113.5 0.0 1.3e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 Nicastrin Ncstrn_small PF18266.1 KII69560.1 - 7.1e-13 48.9 0.2 1.4e-12 47.9 0.2 1.6 1 0 0 1 1 1 1 Nicastrin small lobe RRM_1 PF00076.22 KII69564.1 - 5.4e-11 42.1 0.1 9.4e-11 41.4 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 KII69564.1 - 0.027 14.7 1.7 0.031 14.5 0.1 1.9 2 1 1 3 3 3 0 BRCA1-associated protein 2 Formin_GBD_N PF18382.1 KII69564.1 - 0.064 13.7 0.0 0.1 13.1 0.0 1.3 1 0 0 1 1 1 0 Formin N-terminal GTPase-binding domain HECT PF00632.25 KII69565.1 - 4.5e-86 289.1 0.5 5.7e-86 288.8 0.5 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KII69566.1 - 2.2e-08 34.0 1.4 0.003 17.6 0.0 2.9 3 0 0 3 3 3 2 WW domain DivIC PF04977.15 KII69566.1 - 0.09 12.6 0.2 0.13 12.1 0.0 1.4 2 0 0 2 2 2 0 Septum formation initiator Ion_trans_2 PF07885.16 KII69567.1 - 7.8e-07 29.0 7.4 2.5e-06 27.4 7.4 1.9 1 1 0 1 1 1 1 Ion channel LapA_dom PF06305.11 KII69567.1 - 0.0034 17.2 0.2 0.031 14.1 0.1 2.5 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain RtcR PF06956.11 KII69567.1 - 0.019 14.4 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Regulator of RNA terminal phosphate cyclase HTH_32 PF13565.6 KII69569.1 - 0.1 13.2 0.0 0.45 11.2 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain DUF4325 PF14213.6 KII69570.1 - 0.11 12.2 0.0 0.34 10.7 0.0 1.7 1 0 0 1 1 1 0 STAS-like domain of unknown function (DUF4325) HTH_33 PF13592.6 KII69571.1 - 2.2e-05 24.0 0.0 4.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix Arg_repressor PF01316.21 KII69571.1 - 0.0032 17.2 0.4 0.0071 16.1 0.4 1.6 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain HTH_Tnp_Tc3_2 PF01498.18 KII69571.1 - 0.0096 16.1 0.3 0.022 15.0 0.3 1.6 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 KII69571.1 - 0.039 13.7 0.7 0.31 10.9 0.0 2.7 3 0 0 3 3 3 0 Homeodomain-like domain Fer2_BFD PF04324.15 KII69571.1 - 0.075 13.4 0.9 1.4 9.3 0.0 2.7 2 1 1 3 3 3 0 BFD-like [2Fe-2S] binding domain gag-asp_proteas PF13975.6 KII69574.1 - 0.0016 18.9 0.1 0.005 17.4 0.1 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII69574.1 - 0.014 16.1 0.2 0.028 15.1 0.2 1.5 1 0 0 1 1 1 0 Aspartyl protease Phospholamban PF04272.14 KII69574.1 - 0.038 13.5 0.0 0.1 12.1 0.0 1.8 1 0 0 1 1 1 0 Phospholamban DDE_3 PF13358.6 KII69575.1 - 5.3e-16 58.7 0.3 6.6e-16 58.4 0.3 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease ArsC PF03960.15 KII69580.1 - 0.0083 16.1 0.2 0.072 13.1 0.1 2.0 1 1 1 2 2 2 1 ArsC family rve PF00665.26 KII69581.1 - 2.9e-17 62.9 0.0 5.7e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII69581.1 - 4.1e-15 55.6 1.1 1.1e-14 54.2 1.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII69581.1 - 0.00038 20.2 0.1 0.00085 19.0 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Inhibitor_I67 PF11405.8 KII69581.1 - 9.4 6.6 7.7 0.51 10.6 1.2 2.2 2 0 0 2 2 2 0 Bromelain inhibitor VI TOH_N PF12549.8 KII69587.1 - 0.053 13.4 1.3 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal TLD PF07534.16 KII69589.1 - 6e-19 68.6 0.6 7.1e-19 68.4 0.6 1.0 1 0 0 1 1 1 1 TLD GATA PF00320.27 KII69591.1 - 1.2e-14 53.6 6.1 1.2e-14 53.6 6.1 1.8 2 0 0 2 2 2 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 KII69591.1 - 0.26 10.8 13.0 0.44 10.1 4.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding zf-UBP PF02148.19 KII69591.1 - 0.67 10.3 8.1 3.9 7.9 5.6 2.5 1 1 1 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein zf-AN1 PF01428.16 KII69591.1 - 0.94 9.7 11.6 0.21 11.8 4.0 2.8 2 1 0 2 2 2 0 AN1-like Zinc finger eIF-5_eIF-2B PF01873.17 KII69591.1 - 1.3 8.9 8.8 6 6.8 0.3 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 FYVE PF01363.21 KII69591.1 - 1.9 8.7 14.9 21 5.4 14.9 2.3 1 1 1 2 2 2 0 FYVE zinc finger zinc_ribbon_10 PF10058.9 KII69592.1 - 0.002 17.8 1.5 0.0067 16.1 1.5 1.9 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein zf-RING_10 PF16685.5 KII69592.1 - 0.046 13.9 0.4 0.091 12.9 0.4 1.6 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-TFIIB PF13453.6 KII69592.1 - 0.062 12.6 0.4 0.12 11.7 0.4 1.4 1 0 0 1 1 1 0 Transcription factor zinc-finger FYVE PF01363.21 KII69592.1 - 0.11 12.7 1.7 0.51 10.5 0.9 2.2 1 1 1 2 2 2 0 FYVE zinc finger B56 PF01603.20 KII69593.1 - 0.00036 19.6 0.3 0.00037 19.6 0.3 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) RALF PF05498.11 KII69593.1 - 0.07 14.1 0.4 1.9 9.5 0.0 2.1 1 1 1 2 2 2 0 Rapid ALkalinization Factor (RALF) DDE_Tnp_IS1595 PF12762.7 KII69594.1 - 0.037 14.0 0.0 0.042 13.9 0.0 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain Vps26 PF03643.15 KII69595.1 - 0.015 14.3 0.2 0.016 14.2 0.2 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 rve PF00665.26 KII69598.1 - 0.014 15.6 0.0 0.045 13.9 0.0 1.8 3 0 0 3 3 3 0 Integrase core domain SNAP PF14938.6 KII69601.1 - 0.0021 17.5 0.6 0.0025 17.3 0.6 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SNAP PF14938.6 KII69602.1 - 2.3e-11 43.6 3.0 4.3e-11 42.8 3.0 1.5 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Osmo_CC PF08946.10 KII69602.1 - 0.25 11.6 2.7 0.26 11.6 0.2 2.2 3 0 0 3 3 3 0 Osmosensory transporter coiled coil Spy1 PF11357.8 KII69604.1 - 0.0099 16.2 0.3 0.013 15.7 0.3 1.2 1 0 0 1 1 1 1 Cell cycle regulatory protein Spy1 PF11357.8 KII69605.1 - 0.003 17.8 0.3 0.0043 17.3 0.3 1.2 1 0 0 1 1 1 1 Cell cycle regulatory protein EPL1 PF10513.9 KII69606.1 - 7.2e-08 33.0 5.7 6e-07 30.0 2.1 3.4 2 1 0 2 2 2 1 Enhancer of polycomb-like Ovate PF04844.13 KII69606.1 - 0.067 13.2 0.0 0.21 11.6 0.0 1.9 1 0 0 1 1 1 0 Transcriptional repressor, ovate zf-BED PF02892.15 KII69608.1 - 2.9e-05 24.0 0.8 5.6e-05 23.1 0.3 1.8 2 0 0 2 2 2 1 BED zinc finger Asp PF00026.23 KII69610.1 - 8.9e-96 321.0 1.0 1.1e-95 320.7 1.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KII69610.1 - 8.9e-15 55.4 0.5 7.3e-13 49.1 0.5 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KII69610.1 - 0.0096 16.6 0.0 2.2 9.0 0.0 3.1 3 0 0 3 3 3 1 Aspartyl protease Gelsolin PF00626.22 KII69613.1 - 3.3e-37 126.2 0.0 1.2e-13 50.8 0.0 3.2 3 0 0 3 3 3 3 Gelsolin repeat Inovirus_Gp2 PF11726.8 KII69613.1 - 0.11 12.5 0.7 0.32 10.9 0.0 2.0 3 0 0 3 3 3 0 Inovirus Gp2 DCX PF03607.17 KII69614.1 - 7.9e-09 35.5 0.1 5.7e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 Doublecortin HTH_micro PF17007.5 KII69614.1 - 0.003 16.5 1.3 0.032 13.1 0.7 2.1 2 0 0 2 2 2 1 HTH-like Late_protein_L2 PF00513.18 KII69614.1 - 0.013 14.6 1.1 0.016 14.3 1.1 1.1 1 0 0 1 1 1 0 Late Protein L2 DUF908 PF06012.12 KII69614.1 - 0.04 13.3 4.2 0.05 13.0 4.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) KIP1 PF07765.12 KII69614.1 - 0.077 13.1 0.3 6 7.1 0.1 2.4 2 0 0 2 2 2 0 KIP1-like protein Mod_r PF07200.13 KII69615.1 - 0.0053 16.9 0.4 0.0065 16.6 0.4 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein RAP-1 PF03085.15 KII69615.1 - 0.011 15.5 0.1 0.015 15.0 0.1 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) GCN5L1 PF06320.13 KII69615.1 - 0.041 14.0 0.1 0.066 13.4 0.1 1.3 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Syntaxin_2 PF14523.6 KII69615.1 - 0.044 14.1 0.6 0.055 13.8 0.6 1.1 1 0 0 1 1 1 0 Syntaxin-like protein DUF948 PF06103.11 KII69615.1 - 0.096 13.0 0.1 0.096 13.0 0.1 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DAO_C PF16901.5 KII69615.1 - 0.11 12.3 0.2 0.14 12.0 0.2 1.1 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase DUF919 PF06034.11 KII69615.1 - 0.86 9.5 5.2 0.4 10.6 2.0 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Lectin_leg-like PF03388.13 KII69616.1 - 2.3e-37 128.6 1.1 2.6e-37 128.4 1.1 1.0 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 KII69616.1 - 5.7e-05 23.2 0.8 7.1e-05 22.9 0.8 1.1 1 0 0 1 1 1 1 Bacterial lectin Clathrin_lg_ch PF01086.17 KII69617.1 - 4.3e-07 30.2 17.6 5.1e-07 30.0 17.6 1.0 1 0 0 1 1 1 1 Clathrin light chain V-ATPase_G PF03179.15 KII69617.1 - 1.6 9.3 15.5 0.14 12.7 9.8 1.9 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit DivIC PF04977.15 KII69617.1 - 2.2 8.1 9.4 1.5 8.6 7.8 1.7 2 0 0 2 2 2 0 Septum formation initiator Frag1 PF10277.9 KII69618.1 - 2.9e-05 23.7 9.4 3.4e-05 23.5 9.4 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Oxidored_q4 PF00507.19 KII69618.1 - 2.7 8.2 9.1 0.54 10.4 5.4 1.7 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Claudin_3 PF06653.11 KII69618.1 - 4 7.3 14.3 1.1 9.2 5.9 1.9 1 1 1 2 2 2 0 Tight junction protein, Claudin-like GWT1 PF06423.12 KII69618.1 - 4.2 7.5 8.9 5.1 7.2 8.5 1.3 1 1 0 1 1 1 0 GWT1 KH_1 PF00013.29 KII69619.1 - 9.9e-07 28.5 0.5 2e-06 27.5 0.5 1.5 1 0 0 1 1 1 1 KH domain STAR_dimer PF16544.5 KII69619.1 - 2.4e-06 27.0 0.5 4.2e-06 26.2 0.5 1.4 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein Iron_permease PF04120.12 KII69619.1 - 0.2 11.4 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Low affinity iron permease WD40 PF00400.32 KII69620.1 - 1.4e-21 76.4 11.4 0.0001 23.0 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII69620.1 - 0.001 19.3 1.2 0.68 10.3 0.0 3.7 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Dimer_Tnp_hAT PF05699.14 KII69621.1 - 3.5e-07 29.9 0.0 4.5e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Gelsolin PF00626.22 KII69622.1 - 5.1e-07 29.5 0.0 6.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Gelsolin repeat WD40 PF00400.32 KII69623.1 - 1e-29 102.1 21.2 1.9e-05 25.3 0.1 9.5 10 0 0 10 10 10 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII69623.1 - 7.7e-14 51.8 1.8 0.068 13.5 0.0 6.8 4 3 4 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KII69623.1 - 2.7e-08 33.9 0.7 0.0076 16.1 0.0 5.0 4 2 1 5 5 5 2 Eukaryotic translation initiation factor eIF2A Tox-SGS PF15651.6 KII69623.1 - 0.078 13.2 0.6 4.6 7.5 0.2 3.1 3 0 0 3 3 3 0 Salivary glad secreted protein domain toxin HRM PF02793.22 KII69624.1 - 3.9e-08 33.5 0.8 6e-08 32.9 0.8 1.3 1 0 0 1 1 1 1 Hormone receptor domain DUF5344 PF17279.2 KII69624.1 - 0.051 14.2 0.1 0.091 13.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5344) PAH PF02671.21 KII69625.1 - 1.2e-10 41.4 0.2 2.2e-10 40.5 0.2 1.5 1 0 0 1 1 1 1 Paired amphipathic helix repeat DUF4487 PF14868.6 KII69625.1 - 0.095 11.5 0.2 2.2 7.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4487) COX7C PF02935.16 KII69625.1 - 0.45 10.8 3.1 16 5.9 0.1 3.3 2 1 1 3 3 3 0 Cytochrome c oxidase subunit VIIc Sin3a_C PF16879.5 KII69626.1 - 8.9e-29 101.1 8.3 1.7e-28 100.1 8.3 1.5 1 0 0 1 1 1 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 KII69626.1 - 8.5e-20 70.7 0.0 2.6e-19 69.1 0.0 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor HHH_7 PF14635.6 KII69626.1 - 0.059 13.7 0.0 0.27 11.6 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif ELO PF01151.18 KII69628.1 - 2e-47 161.8 27.3 2.4e-47 161.6 27.3 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CCSMST1 PF15013.6 KII69628.1 - 0.067 13.4 2.4 0.21 11.8 2.4 1.8 1 0 0 1 1 1 0 CCSMST1 family DDE_3 PF13358.6 KII69630.1 - 7.7e-06 25.7 0.0 1.3e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease FBA_2 PF07735.17 KII69630.1 - 0.98 9.6 4.9 4.3 7.5 0.1 3.2 1 1 2 3 3 3 0 F-box associated TRI5 PF06330.11 KII69634.1 - 0.095 11.6 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) DCAF17 PF15802.5 KII69635.1 - 0.035 12.8 0.0 0.039 12.6 0.0 1.1 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 17 DUF4945 PF16303.5 KII69635.1 - 0.089 12.7 0.0 0.096 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4945) DDE_3 PF13358.6 KII69638.1 - 0.0065 16.2 0.2 0.0074 16.1 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease CBM46 PF18448.1 KII69638.1 - 0.075 13.4 0.0 0.096 13.0 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain Vps39_1 PF10366.9 KII69640.1 - 1e-06 29.0 0.1 3.8e-06 27.2 0.1 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 KxDL PF10241.9 KII69642.1 - 5e-06 26.7 2.3 6.7e-06 26.3 2.3 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein OmpH PF03938.14 KII69642.1 - 0.0042 17.4 0.3 0.0049 17.2 0.3 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) ING PF12998.7 KII69642.1 - 0.08 13.5 2.5 0.11 13.1 2.5 1.3 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding DUF1664 PF07889.12 KII69642.1 - 0.13 12.3 0.9 0.17 11.9 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) T-box PF00907.22 KII69643.1 - 4.5e-34 118.3 0.1 5.8e-34 118.0 0.1 1.1 1 0 0 1 1 1 1 T-box Glyco_hydro_36C PF16874.5 KII69643.1 - 0.13 12.7 0.0 0.23 12.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 36 C-terminal domain ERCC4 PF02732.15 KII69646.1 - 3e-16 60.0 0.0 6.5e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain rve PF00665.26 KII69647.1 - 5.3e-06 26.6 0.0 1.1e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII69647.1 - 8.2e-05 22.3 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII69647.1 - 0.042 14.0 0.0 0.079 13.1 0.0 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain AT_hook PF02178.19 KII69647.1 - 3.8 7.7 8.9 8.4 6.7 8.9 1.5 1 0 0 1 1 1 0 AT hook motif Rad10 PF03834.14 KII69649.1 - 1.3e-29 102.5 0.8 8.9e-29 99.8 0.1 2.2 2 1 0 2 2 2 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) SNF2_N PF00176.23 KII69650.1 - 1e-54 185.6 2.0 1.7e-54 184.9 2.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 KII69650.1 - 8.6e-08 32.4 0.0 2.5e-07 30.8 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3535 PF12054.8 KII69650.1 - 0.0024 17.2 0.0 0.005 16.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3535) SWI2_SNF2 PF18766.1 KII69650.1 - 0.0056 16.4 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase HEAT PF02985.22 KII69650.1 - 0.057 13.7 1.8 2.6 8.5 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat PCM1_C PF15717.5 KII69650.1 - 0.098 11.3 0.2 0.16 10.6 0.2 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Pro_isomerase PF00160.21 KII69652.1 - 2.5e-09 37.6 0.0 5.7e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD KxDL PF10241.9 KII69652.1 - 0.012 15.9 0.5 0.012 15.9 0.5 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein MetOD1 PF18546.1 KII69652.1 - 0.049 13.6 0.9 0.049 13.6 0.9 2.6 3 0 0 3 3 3 0 Metanogen output domain 1 Cyc-maltodext_C PF10438.9 KII69652.1 - 0.093 12.8 0.3 0.24 11.5 0.3 1.7 1 0 0 1 1 1 0 Cyclo-malto-dextrinase C-terminal domain LPP PF04728.13 KII69652.1 - 0.26 11.7 3.5 0.13 12.7 0.7 1.9 2 0 0 2 2 2 0 Lipoprotein leucine-zipper XhlA PF10779.9 KII69652.1 - 1.5 9.1 12.1 0.48 10.7 4.3 2.9 2 1 0 2 2 2 0 Haemolysin XhlA SLC35F PF06027.12 KII69653.1 - 3.5e-30 105.6 25.2 4.2e-30 105.3 25.2 1.1 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 KII69653.1 - 8.4e-08 31.5 10.2 8.4e-08 31.5 10.2 1.6 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 KII69653.1 - 2.8e-07 30.8 33.5 4.8e-05 23.5 11.3 2.3 2 0 0 2 2 2 2 EamA-like transporter family Tom6 PF17112.5 KII69653.1 - 0.038 13.5 2.0 0.36 10.4 0.1 2.5 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal Sec20 PF03908.13 KII69653.1 - 0.064 13.2 0.2 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 Sec20 Brucella_OMP2 PF05244.11 KII69654.1 - 0.2 11.0 0.0 0.28 10.5 0.0 1.1 1 0 0 1 1 1 0 Brucella outer membrane protein 2 Ank_2 PF12796.7 KII69655.1 - 3.8e-19 69.0 0.1 7e-08 32.9 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII69655.1 - 1.2e-16 60.9 0.7 9.1e-05 22.9 0.0 4.3 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KII69655.1 - 1.6e-13 50.5 0.2 0.00056 20.2 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII69655.1 - 2.1e-10 39.9 4.0 0.53 11.0 0.0 6.0 5 1 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KII69655.1 - 0.00012 22.4 5.6 27 5.4 0.1 5.9 6 0 0 6 6 6 2 Ankyrin repeat Pkinase PF00069.25 KII69656.1 - 2.5e-29 102.5 0.1 5.2e-29 101.4 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII69656.1 - 1.9e-19 70.0 0.0 2.8e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PTEN_C2 PF10409.9 KII69656.1 - 7.8e-10 38.6 0.3 2.5e-09 37.0 0.3 1.9 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DnaJ PF00226.31 KII69656.1 - 2.8e-05 24.1 0.1 8.9e-05 22.5 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 KII69658.1 - 6.1e-12 45.4 0.4 6.6e-12 45.3 0.4 1.0 1 0 0 1 1 1 1 Thioredoxin DUF5442 PF17514.2 KII69658.1 - 0.014 15.6 0.2 0.016 15.4 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5442) Salp15 PF12115.8 KII69658.1 - 0.04 14.4 0.2 0.05 14.0 0.2 1.2 1 0 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation AhpC-TSA PF00578.21 KII69658.1 - 0.04 13.8 0.7 0.042 13.8 0.7 1.2 1 1 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 KII69658.1 - 0.05 13.3 0.0 0.05 13.3 0.0 1.2 1 0 0 1 1 1 0 Redoxin Thioredoxin_2 PF13098.6 KII69658.1 - 0.093 13.2 1.1 0.14 12.6 1.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KII69658.1 - 0.11 12.9 0.2 0.15 12.4 0.2 1.2 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin PF00085.20 KII69659.1 - 1e-10 41.5 0.0 1.2e-10 41.2 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KII69659.1 - 2.8e-06 27.7 0.1 7.2e-06 26.4 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 KII69659.1 - 0.00026 20.9 0.1 0.00046 20.1 0.1 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 KII69659.1 - 0.00069 19.9 0.0 0.001 19.4 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin-like KaiB PF07689.12 KII69659.1 - 0.0039 16.9 0.0 0.005 16.5 0.0 1.2 1 0 0 1 1 1 1 KaiB domain Thioredoxin_9 PF14595.6 KII69659.1 - 0.0095 15.7 0.1 0.011 15.6 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 KII69659.1 - 0.01 15.6 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 0 Redoxin Glutaredoxin PF00462.24 KII69659.1 - 0.077 13.2 0.0 0.13 12.5 0.0 1.5 1 1 0 1 1 1 0 Glutaredoxin Zn_Tnp_IS1595 PF12760.7 KII69660.1 - 0.024 14.6 1.0 0.038 14.0 1.0 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Syntaxin-18_N PF10496.9 KII69661.1 - 0.41 10.9 2.2 1.9 8.8 0.1 2.9 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus DUF383 PF04063.14 KII69662.1 - 0.044 13.5 0.1 0.047 13.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF383) Sterile PF03015.19 KII69662.1 - 0.055 13.7 0.4 0.073 13.3 0.4 1.3 1 0 0 1 1 1 0 Male sterility protein TRAP-gamma PF07074.12 KII69666.1 - 6.1e-21 74.7 7.0 7.8e-21 74.4 7.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) DUF2981 PF11200.8 KII69666.1 - 0.08 12.7 3.0 0.096 12.4 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) 7TM_GPCR_Srt PF10321.9 KII69666.1 - 0.52 9.2 11.8 0.05 12.6 5.2 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srt Nuf2 PF03800.14 KII69667.1 - 0.0032 17.6 0.1 0.0057 16.8 0.1 1.4 1 1 0 1 1 1 1 Nuf2 family Synaptobrevin PF00957.21 KII69668.1 - 8.1e-20 70.4 0.0 9.6e-20 70.2 0.0 1.1 1 0 0 1 1 1 1 Synaptobrevin DNA_ligase_A_M PF01068.21 KII69668.1 - 0.025 14.2 0.1 0.029 14.0 0.1 1.0 1 0 0 1 1 1 0 ATP dependent DNA ligase domain Sec20 PF03908.13 KII69668.1 - 0.19 11.6 1.3 0.32 10.9 1.3 1.5 1 1 0 1 1 1 0 Sec20 DUF1394 PF07159.12 KII69669.1 - 1.4e-17 63.9 0.0 1.9e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Nop PF01798.18 KII69669.1 - 0.0063 16.0 0.1 0.0074 15.8 0.1 1.1 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin ApoLp-III PF07464.11 KII69669.1 - 0.051 13.7 0.2 0.13 12.3 0.1 1.7 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Pox_MCEL PF03291.16 KII69671.1 - 9.9e-61 205.7 4.4 1.2e-60 205.4 4.4 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 KII69671.1 - 1e-09 39.0 0.0 1.9e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII69671.1 - 0.0031 18.1 0.0 0.0056 17.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NIF3 PF01784.18 KII69671.1 - 0.0042 16.7 0.0 0.0061 16.2 0.0 1.2 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) MTS PF05175.14 KII69671.1 - 0.0059 16.2 0.0 0.018 14.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 KII69671.1 - 0.0061 16.4 0.0 0.013 15.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KII69671.1 - 0.012 15.4 0.0 0.026 14.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain AviRa PF11599.8 KII69671.1 - 0.035 13.6 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_15 PF09445.10 KII69671.1 - 0.039 13.5 0.0 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase BACK PF07707.15 KII69671.1 - 0.051 13.7 0.1 0.17 12.0 0.1 2.0 1 0 0 1 1 1 0 BTB And C-terminal Kelch MULE PF10551.9 KII69672.1 - 4.7e-06 26.9 0.0 1e-05 25.8 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Ribosomal_S5_C PF03719.15 KII69675.1 - 7e-16 57.4 0.0 1.1e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KII69675.1 - 0.0049 16.8 1.1 0.062 13.3 0.1 2.4 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Aph-1 PF06105.12 KII69678.1 - 6.8e-25 87.8 20.2 8.8e-25 87.5 20.2 1.0 1 0 0 1 1 1 1 Aph-1 protein GTP_EFTU PF00009.27 KII69679.1 - 1e-43 149.2 0.0 1.6e-43 148.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KII69679.1 - 7.4e-14 52.0 1.8 2.5e-12 47.1 0.0 3.4 5 0 0 5 5 5 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 KII69679.1 - 0.00014 21.9 0.1 0.001 19.1 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KII69679.1 - 0.014 14.6 0.2 0.034 13.3 0.2 1.6 2 0 0 2 2 2 0 G-protein alpha subunit G-alpha PF00503.20 KII69680.1 - 4.4e-27 95.2 6.7 5e-27 95.0 6.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KII69680.1 - 0.0024 17.4 0.4 0.0043 16.5 0.4 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family RE_HaeIII PF09556.10 KII69680.1 - 0.0039 16.3 0.1 0.0071 15.5 0.1 1.3 1 0 0 1 1 1 1 HaeIII restriction endonuclease CBM_14 PF01607.24 KII69681.1 - 9.9e-06 25.6 7.3 9.9e-06 25.6 7.3 1.9 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain GLEYA PF10528.9 KII69681.1 - 0.00032 21.1 0.3 0.00053 20.4 0.3 1.3 1 0 0 1 1 1 1 GLEYA domain PA14 PF07691.12 KII69681.1 - 0.0083 15.9 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Hyd_WA PF06462.12 KII69682.1 - 2.4e-12 46.6 3.5 0.0024 17.8 0.0 4.9 4 0 0 4 4 4 4 Propeller CAP PF00188.26 KII69682.1 - 1.5e-11 45.3 4.2 5e-11 43.5 4.2 2.0 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Ribosomal_S6e PF01092.19 KII69684.1 - 6.9e-24 84.2 0.2 1.8e-23 82.9 0.2 1.7 1 0 0 1 1 1 1 Ribosomal protein S6e MULE PF10551.9 KII69685.1 - 3.7e-10 40.1 2.7 3.9e-10 40.0 1.3 1.8 2 0 0 2 2 2 1 MULE transposase domain DUF3819 PF12842.7 KII69685.1 - 0.11 12.5 0.3 0.18 11.7 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) FLYWCH PF04500.16 KII69686.1 - 9.1e-11 41.7 3.1 1.4e-10 41.1 3.1 1.4 1 1 0 1 1 1 1 FLYWCH zinc finger domain PhoLip_ATPase_C PF16212.5 KII69687.1 - 4.1e-54 184.0 27.4 6.5e-54 183.3 27.4 1.3 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 KII69687.1 - 1.2e-11 44.5 0.1 9.4e-10 38.5 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KII69687.1 - 3.2e-09 37.4 0.6 1.8e-05 25.1 0.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KII69687.1 - 0.00031 20.6 1.8 0.00079 19.2 1.8 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Porphobil_deam PF01379.20 KII69687.1 - 0.14 11.7 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 Porphobilinogen deaminase, dipyromethane cofactor binding domain PhoLip_ATPase_N PF16209.5 KII69688.1 - 2.1e-26 91.4 1.6 3.6e-26 90.6 1.6 1.3 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 KII69688.1 - 9.2e-07 28.6 1.5 9.2e-07 28.6 0.2 1.6 1 1 1 2 2 2 1 E1-E2 ATPase zf-CGNR PF11706.8 KII69688.1 - 0.043 13.7 0.3 0.068 13.0 0.3 1.3 1 0 0 1 1 1 0 CGNR zinc finger MS_channel PF00924.18 KII69688.1 - 0.76 9.3 6.8 2.1 7.8 6.8 1.8 1 1 0 1 1 1 0 Mechanosensitive ion channel DUF2045 PF09741.9 KII69689.1 - 9.1e-26 90.7 2.7 1.3e-25 90.1 2.7 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) RRM_1 PF00076.22 KII69690.1 - 2.3e-33 113.8 0.4 2.1e-17 62.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII69690.1 - 9.3e-12 44.9 0.1 6.7e-05 22.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.6 KII69690.1 - 0.0093 16.2 0.1 1.6 8.9 0.0 2.9 1 1 2 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.11 KII69690.1 - 0.028 14.4 0.1 5.5 7.1 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif RRM_5 PF13893.6 KII69690.1 - 0.084 12.5 0.0 0.94 9.1 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 KII69690.1 - 0.088 12.8 0.1 1.1 9.2 0.0 2.2 2 1 0 2 2 2 0 RL domain P16-Arc PF04699.14 KII69691.1 - 6.4e-27 94.9 0.1 8.1e-27 94.5 0.1 1.1 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Anophelin PF10731.9 KII69691.1 - 0.24 11.2 1.0 0.29 11.0 0.1 1.5 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito GST_C_6 PF17171.4 KII69692.1 - 1.2e-15 57.0 0.8 5.4e-15 54.9 0.8 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KII69692.1 - 4.4e-07 30.6 0.0 9.4e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain ASF1_hist_chap PF04729.13 KII69693.1 - 7.8e-62 207.8 0.5 8.9e-62 207.6 0.5 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Pannexin_like PF12534.8 KII69696.1 - 1.3e-06 27.8 19.4 0.00041 19.5 8.4 3.0 1 1 1 3 3 3 2 Pannexin-like TM region of LRRC8 OTU PF02338.19 KII69696.1 - 0.0099 16.4 0.1 0.043 14.3 0.0 1.9 2 0 0 2 2 2 1 OTU-like cysteine protease RhoGAP PF00620.27 KII69697.1 - 1.1e-26 93.5 0.5 2.9e-26 92.1 0.1 1.8 2 0 0 2 2 2 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 KII69697.1 - 3.9e-16 59.5 0.9 7.8e-16 58.5 0.9 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KII69697.1 - 0.002 17.9 1.4 0.0063 16.2 1.4 1.8 1 1 0 1 1 1 1 CRAL/TRIO domain CdvA PF18822.1 KII69697.1 - 0.061 13.2 0.3 0.14 12.0 0.3 1.5 1 0 0 1 1 1 0 CdvA-like coiled-coil domain EamA PF00892.20 KII69698.1 - 0.98 9.6 15.7 0.065 13.4 8.6 2.4 2 1 1 3 3 3 0 EamA-like transporter family DUF5416 PF17437.2 KII69702.1 - 0.016 15.0 1.7 0.023 14.5 1.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5416) RasGEF PF00617.19 KII69703.1 - 4.1e-11 43.4 0.6 2.3e-10 41.0 0.1 2.1 2 1 0 2 2 2 1 RasGEF domain DUF3541 PF12060.8 KII69703.1 - 0.027 14.1 0.1 0.045 13.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3541) ThiF PF00899.21 KII69704.1 - 2.2e-23 82.9 0.0 2.6e-23 82.7 0.0 1.0 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 KII69704.1 - 0.0011 18.3 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 KII69704.1 - 0.021 14.1 0.5 0.025 13.8 0.5 1.1 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 KII69704.1 - 0.022 14.8 0.1 0.026 14.6 0.1 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 KII69704.1 - 0.038 13.6 0.1 0.047 13.3 0.1 1.1 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 KII69704.1 - 0.065 12.9 0.0 0.079 12.6 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 KII69704.1 - 0.07 13.4 0.1 0.08 13.2 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 KII69704.1 - 0.078 13.2 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 KII69704.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Na_Ca_ex PF01699.24 KII69707.1 - 5.8e-34 117.2 23.6 3e-21 76.0 18.3 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein YfhO PF09586.10 KII69707.1 - 0.094 10.9 12.4 0.13 10.5 12.4 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO gag-asp_proteas PF13975.6 KII69708.1 - 0.0033 17.9 0.0 0.0054 17.3 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII69708.1 - 0.0035 17.9 0.0 0.0058 17.2 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII69708.1 - 0.02 15.2 0.0 0.029 14.7 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease IBN_N PF03810.19 KII69709.1 - 2.3e-08 33.8 1.6 6.2e-08 32.5 0.1 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 KII69709.1 - 1.5e-07 31.7 0.1 0.0059 17.1 0.0 5.8 7 0 0 7 7 7 1 HEAT-like repeat HEAT PF02985.22 KII69709.1 - 2.1e-07 30.6 3.6 0.59 10.5 0.1 6.3 7 0 0 7 7 7 2 HEAT repeat Vac14_Fab1_bd PF12755.7 KII69709.1 - 8.3e-06 26.3 11.5 0.21 12.2 0.1 6.3 5 2 1 6 6 6 2 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 KII69709.1 - 0.0031 17.3 7.8 6.6 6.4 0.0 5.9 4 2 1 6 6 6 1 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 KII69709.1 - 0.0084 16.2 10.4 1.4 8.9 0.0 5.1 5 2 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 KII69709.1 - 0.016 15.1 0.2 9 6.3 0.0 4.3 3 1 0 3 3 3 0 UME (NUC010) domain Arm PF00514.23 KII69709.1 - 0.033 14.2 6.2 66 3.8 0.0 6.5 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat FANCI_S2 PF14676.6 KII69709.1 - 1.8 8.8 8.6 13 6.0 0.0 4.5 5 1 1 6 6 6 0 FANCI solenoid 2 Helicase_C PF00271.31 KII69710.1 - 9e-28 96.8 0.6 9e-28 96.8 0.6 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DNA_pol3_delta PF06144.13 KII69710.1 - 0.023 14.5 3.3 0.27 11.0 0.4 2.2 2 0 0 2 2 2 0 DNA polymerase III, delta subunit FAD_binding_1 PF00667.20 KII69710.1 - 0.047 13.2 0.1 0.075 12.6 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain FleQ PF06490.11 KII69710.1 - 0.055 13.9 0.1 0.15 12.5 0.1 1.8 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ NS3 PF17530.2 KII69716.1 - 0.027 14.0 0.3 0.049 13.2 0.3 1.4 1 0 0 1 1 1 0 Non-structural protein NS3 Gag_p24 PF00607.20 KII69716.1 - 0.037 13.9 0.1 0.07 13.0 0.1 1.4 1 0 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) zf-CCHC PF00098.23 KII69716.1 - 0.18 11.9 4.6 0.23 11.6 0.6 2.6 2 0 0 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 KII69717.1 - 8.1e-27 93.2 0.0 1.2e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII69717.1 - 5.3e-16 58.8 0.0 9.1e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase HLH PF00010.26 KII69718.1 - 2e-08 34.1 2.9 3.6e-08 33.2 1.8 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SprT-like PF10263.9 KII69720.1 - 2.6e-26 91.7 0.1 4.4e-26 91.0 0.1 1.4 1 0 0 1 1 1 1 SprT-like family AdoHcyase_NAD PF00670.21 KII69721.1 - 2.2e-36 125.4 0.2 2.7e-36 125.1 0.2 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 KII69721.1 - 1.3e-27 96.7 0.0 1.4e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase THF_DHG_CYH_C PF02882.19 KII69721.1 - 0.0047 16.3 0.2 0.0079 15.5 0.2 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain CHASE4 PF05228.13 KII69721.1 - 0.014 15.6 0.0 0.02 15.1 0.0 1.2 1 0 0 1 1 1 0 CHASE4 domain 2-Hacid_dh_C PF02826.19 KII69721.1 - 0.015 14.6 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sp38 PF07354.12 KII69724.1 - 0.066 12.6 0.4 0.074 12.5 0.4 1.1 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Xpo1 PF08389.12 KII69724.1 - 0.34 11.0 3.3 1 9.4 0.4 2.0 2 0 0 2 2 2 0 Exportin 1-like protein HTH_Tnp_Tc5 PF03221.16 KII69726.1 - 1.1e-05 25.4 0.1 2e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain FapA PF03961.13 KII69729.1 - 0.01 14.5 0.9 0.012 14.3 0.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A PCRF PF03462.18 KII69729.1 - 0.018 14.9 0.4 0.025 14.4 0.4 1.2 1 0 0 1 1 1 0 PCRF domain betaPIX_CC PF16523.5 KII69729.1 - 0.5 10.2 4.0 0.25 11.2 1.7 1.7 2 0 0 2 2 2 0 betaPIX coiled coil BLOC1_2 PF10046.9 KII69729.1 - 0.54 10.6 4.4 0.84 10.0 2.8 2.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ANAPC9 PF12856.7 KII69732.1 - 0.23 11.7 0.3 0.33 11.2 0.3 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 DUF3305 PF11749.8 KII69733.1 - 0.15 12.2 0.1 0.21 11.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3305) DUF1180 PF06679.12 KII69733.1 - 1.9 8.9 6.3 0.74 10.2 2.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1180) Srg PF02118.21 KII69736.1 - 0.0051 16.5 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Srg family chemoreceptor PDGF_N PF04692.13 KII69736.1 - 0.085 13.7 0.5 0.27 12.0 0.5 2.0 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region Chordopox_A13L PF05961.11 KII69743.1 - 0.019 15.2 2.3 0.83 9.9 0.0 2.5 2 1 1 3 3 3 0 Chordopoxvirus A13L protein F-box PF00646.33 KII69744.1 - 0.091 12.7 0.2 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 F-box domain U3_assoc_6 PF08640.11 KII69747.1 - 0.79 9.8 3.7 2.8 8.1 0.0 2.7 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 SH3BGR PF04908.15 KII69748.1 - 9.6e-16 57.8 0.3 1.6e-15 57.1 0.3 1.3 1 1 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 KII69748.1 - 0.0023 18.1 0.0 0.0048 17.1 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Exc PF07825.11 KII69748.1 - 0.033 14.2 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 Excisionase-like protein WH2 PF02205.20 KII69749.1 - 0.00013 21.7 0.0 0.0002 21.1 0.0 1.3 1 0 0 1 1 1 1 WH2 motif CAP_N PF01213.19 KII69749.1 - 0.46 9.9 1.8 0.59 9.6 1.8 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DDE_Tnp_IS1595 PF12762.7 KII69751.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain PRELI PF04707.14 KII69751.1 - 0.023 14.5 0.8 1.6 8.6 0.2 2.1 2 0 0 2 2 2 0 PRELI-like family GDP_Man_Dehyd PF16363.5 KII69751.1 - 0.21 11.0 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RhoGEF PF00621.20 KII69753.1 - 1.2e-09 38.7 7.0 1.2e-09 38.7 7.0 1.6 2 0 0 2 2 2 1 RhoGEF domain Pkinase PF00069.25 KII69754.1 - 1.5e-26 93.4 0.2 1.7e-26 93.1 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII69754.1 - 2.1e-14 53.5 0.0 2.5e-14 53.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KII69755.1 - 4.8e-21 75.3 0.0 5.6e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII69755.1 - 3.7e-09 36.2 0.0 4.7e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII69755.1 - 0.0065 15.8 0.0 0.0075 15.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Sigma_reg_N PF13800.6 KII69757.1 - 0.096 13.0 0.8 0.15 12.3 0.8 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Vac14_Fig4_bd PF11916.8 KII69759.1 - 1e-07 31.8 0.0 2.3e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding DUF2013 PF09431.10 KII69759.1 - 0.37 10.9 4.9 0.08 13.1 0.9 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2013) Myco_arth_vir_N PF09610.10 KII69761.1 - 0.033 14.3 0.5 0.054 13.6 0.1 1.5 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) mRNA_cap_enzyme PF01331.19 KII69762.1 - 6.8e-50 169.6 0.0 1e-49 169.0 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 KII69762.1 - 6.8e-15 55.6 0.1 2e-14 54.1 0.1 1.8 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DSPc PF00782.20 KII69762.1 - 3.4e-12 46.3 0.0 8.9e-12 45.0 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KII69762.1 - 0.0075 16.3 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KII69762.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KII69762.1 - 0.02 15.0 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate DDE_3 PF13358.6 KII69763.1 - 0.0095 15.7 0.0 0.057 13.2 0.0 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII69764.1 - 8.6e-06 25.9 0.1 2.3e-05 24.6 0.1 1.6 2 0 0 2 2 2 1 Integrase core domain FhuF_C PF11575.8 KII69765.1 - 0.047 13.6 0.2 0.17 11.9 0.1 2.0 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain PLDc_2 PF13091.6 KII69766.1 - 5.3e-05 23.1 0.0 7.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 PLD-like domain PLDc_3 PF13918.6 KII69766.1 - 0.00071 19.3 0.0 0.0029 17.3 0.0 1.9 2 1 0 2 2 2 1 PLD-like domain PLDc PF00614.22 KII69766.1 - 0.011 15.8 0.0 0.029 14.5 0.0 1.7 1 0 0 1 1 1 0 Phospholipase D Active site motif PLDc_2 PF13091.6 KII69767.1 - 8.9e-16 58.0 0.0 1.2e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.22 KII69767.1 - 3.7e-05 23.7 0.4 8e-05 22.7 0.2 1.7 2 0 0 2 2 2 1 Phospholipase D Active site motif Cellsynth_D PF03500.13 KII69767.1 - 0.19 11.6 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 Cellulose synthase subunit D RhoGAP PF00620.27 KII69768.1 - 2.1e-27 95.8 0.2 3.9e-27 94.9 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 KII69768.1 - 1.7e-05 24.6 7.7 3.1e-05 23.8 7.7 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 KII69768.1 - 0.003 17.5 5.6 0.006 16.5 5.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 C1_2 PF03107.16 KII69768.1 - 0.14 12.5 5.0 0.28 11.6 5.0 1.5 1 0 0 1 1 1 0 C1 domain PHD PF00628.29 KII69768.1 - 0.33 10.9 7.5 0.73 9.8 7.5 1.6 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 KII69768.1 - 0.47 10.1 4.8 0.93 9.2 4.8 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 KII69768.1 - 2.3 8.6 8.8 5.1 7.5 8.8 1.6 1 0 0 1 1 1 0 RING-like domain Myosin_head PF00063.21 KII69769.1 - 2.3e-27 95.6 6.0 2.8e-27 95.3 6.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_head PF00063.21 KII69770.1 - 7.4e-47 160.0 0.1 1e-46 159.5 0.1 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 KII69770.1 - 0.0011 19.4 0.0 0.0022 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 KII69770.1 - 0.0022 18.3 0.0 0.0042 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KII69770.1 - 0.012 14.6 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 KII69770.1 - 0.014 15.7 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KII69770.1 - 0.029 14.1 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Microtub_bd PF16796.5 KII69770.1 - 0.032 14.2 0.1 0.054 13.4 0.1 1.3 1 0 0 1 1 1 0 Microtubule binding Zeta_toxin PF06414.12 KII69770.1 - 0.18 11.1 0.0 0.34 10.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Voltage_CLC PF00654.20 KII69771.1 - 1.8e-27 96.6 16.4 3e-14 53.0 4.5 3.0 1 1 2 3 3 3 3 Voltage gated chloride channel Ank_2 PF12796.7 KII69773.1 - 1.1e-12 48.4 0.0 1.3e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII69773.1 - 1.1e-08 35.4 0.1 0.00033 21.1 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII69773.1 - 1.1e-07 31.5 0.1 0.02 15.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KII69773.1 - 1.4e-07 31.6 0.2 0.0011 19.3 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat UBA_4 PF14555.6 KII69773.1 - 0.0012 18.6 0.1 0.003 17.3 0.0 1.6 2 0 0 2 2 2 1 UBA-like domain Ank_5 PF13857.6 KII69773.1 - 0.016 15.5 0.0 0.98 9.8 0.0 2.4 1 1 1 2 2 2 0 Ankyrin repeats (many copies) DUF3879 PF12995.7 KII69773.1 - 0.099 12.3 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3879) Ank_2 PF12796.7 KII69774.1 - 6e-11 42.8 0.2 8.1e-09 36.0 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII69774.1 - 7.7e-08 32.7 2.5 2.1e-05 25.0 0.2 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KII69774.1 - 9.9e-08 32.1 0.3 5.6e-05 23.3 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII69774.1 - 8.2e-07 28.9 0.1 0.019 15.5 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KII69774.1 - 0.00048 20.5 0.2 0.64 10.6 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat DUF21 PF01595.20 KII69775.1 - 3.3e-33 114.8 1.1 5.8e-33 114.1 1.1 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KII69775.1 - 3.7e-08 33.7 0.4 0.003 18.0 0.1 3.1 3 0 0 3 3 3 2 CBS domain Dus PF01207.17 KII69776.1 - 0.074 12.1 0.0 0.083 12.0 0.0 1.1 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) DHR-2 PF06920.13 KII69777.1 - 9.6e-128 427.1 3.6 1.2e-127 426.7 3.6 1.0 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 KII69778.1 - 1.3e-14 54.4 0.3 3.2e-14 53.2 0.3 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins RIX1 PF08167.12 KII69778.1 - 1.6 8.4 8.2 5.6 6.7 0.1 3.6 4 0 0 4 4 4 0 rRNA processing/ribosome biogenesis PH PF00169.29 KII69779.1 - 8.8e-09 35.8 0.5 8.8e-09 35.8 0.5 2.2 2 1 1 3 3 3 1 PH domain PH_13 PF16652.5 KII69779.1 - 0.00053 19.8 1.0 0.0017 18.2 0.1 2.2 2 1 0 2 2 2 1 Pleckstrin homology domain DUF3398 PF11878.8 KII69779.1 - 0.052 14.0 0.7 0.39 11.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3398) RNA_pol_Rpc4 PF05132.14 KII69780.1 - 0.014 15.8 1.6 0.018 15.5 1.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Enolase_N PF03952.16 KII69780.1 - 0.074 13.2 0.3 2.8 8.1 0.1 2.1 1 1 0 2 2 2 0 Enolase, N-terminal domain PH PF00169.29 KII69781.1 - 9.1e-06 26.1 0.1 1.6e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_4 PF15404.6 KII69781.1 - 0.0098 15.7 0.2 0.018 14.8 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain DarA_N PF18788.1 KII69781.1 - 0.033 14.3 0.1 3.4 7.8 0.0 2.3 1 1 1 2 2 2 0 Defence against restriction A N-terminal PH_13 PF16652.5 KII69781.1 - 0.073 12.9 0.5 0.22 11.3 0.1 1.9 1 1 0 2 2 2 0 Pleckstrin homology domain DOCK-C2 PF14429.6 KII69782.1 - 3.2e-29 102.1 0.2 7.9e-29 100.9 0.2 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Caleosin PF05042.13 KII69782.1 - 0.083 12.8 0.1 0.2 11.6 0.1 1.6 1 0 0 1 1 1 0 Caleosin related protein DHR-2 PF06920.13 KII69783.1 - 8.4e-25 87.4 0.0 1.3e-24 86.8 0.0 1.2 1 1 0 1 1 1 1 Dock homology region 2 Mod_r PF07200.13 KII69783.1 - 0.017 15.2 0.0 0.073 13.2 0.0 2.1 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Aminotran_1_2 PF00155.21 KII69784.1 - 3.3e-35 122.0 0.0 4e-35 121.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KII69784.1 - 0.00029 20.2 0.0 0.00047 19.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase LEM PF03020.15 KII69785.1 - 3.3e-11 42.5 0.0 6.2e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 LEM domain Ank_5 PF13857.6 KII69785.1 - 9.5e-09 35.4 0.0 0.00029 21.1 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII69785.1 - 4.6e-08 32.7 0.1 0.002 18.5 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 KII69785.1 - 2.1e-07 31.4 0.0 0.0039 17.8 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KII69785.1 - 3.3e-05 24.1 0.1 0.097 13.2 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KII69785.1 - 0.026 15.1 0.1 0.31 11.7 0.1 2.4 1 1 0 1 1 1 0 Ankyrin repeats (many copies) SAP PF02037.27 KII69785.1 - 0.031 14.0 0.0 0.081 12.7 0.0 1.7 1 0 0 1 1 1 0 SAP domain DNA_topoisoIV PF00521.20 KII69787.1 - 8.4e-119 397.2 0.1 1.9e-118 396.1 0.1 1.6 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KII69787.1 - 3.4e-45 153.4 1.1 1.4e-44 151.5 1.1 2.2 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 KII69787.1 - 1.2e-23 83.5 0.5 3e-23 82.2 0.5 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 KII69787.1 - 4.7e-13 49.6 0.1 5.2e-12 46.3 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 KII69787.1 - 2.1e-07 31.1 0.1 1.7e-06 28.2 0.0 2.7 2 0 0 2 2 2 1 Toprim domain 7tm_1 PF00001.21 KII69788.1 - 1.7e-14 53.8 17.6 3.5e-14 52.8 17.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF350 PF03994.14 KII69788.1 - 0.12 12.6 2.8 0.13 12.5 0.4 2.4 1 1 0 2 2 2 0 Domain of Unknown Function (DUF350) SNAP PF14938.6 KII69789.1 - 1.9e-09 37.3 1.4 3.3e-09 36.6 1.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 KII69789.1 - 0.027 13.9 0.0 0.05 13.0 0.0 1.5 1 1 0 1 1 1 0 MalT-like TPR region TPR_1 PF00515.28 KII69789.1 - 0.076 12.9 12.6 0.56 10.1 0.4 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KII69789.1 - 0.12 12.1 4.4 8.9 6.1 0.2 3.6 3 1 0 3 3 3 0 TPR repeat TPR_2 PF07719.17 KII69789.1 - 0.46 10.7 9.6 3.5 8.0 0.2 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII69789.1 - 0.54 10.6 4.3 13 6.3 0.6 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII69790.1 - 0.0063 16.3 6.8 1.6 8.7 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII69790.1 - 0.05 13.7 7.9 0.51 10.6 0.5 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 KII69790.1 - 0.15 11.8 7.2 0.44 10.3 0.2 3.1 3 0 0 3 3 3 0 TPR repeat TPR_8 PF13181.6 KII69790.1 - 0.46 10.8 5.4 7.4 7.1 0.2 3.5 2 1 0 2 2 2 0 Tetratricopeptide repeat NSF PF02071.20 KII69790.1 - 3 9.0 6.5 2.7 9.2 0.1 3.8 3 1 1 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat FLYWCH PF04500.16 KII69791.1 - 0.0032 17.5 2.2 0.011 15.8 1.4 2.0 2 0 0 2 2 2 1 FLYWCH zinc finger domain Cadherin_4 PF17803.1 KII69794.1 - 0.24 12.1 1.3 27 5.5 0.1 2.4 2 0 0 2 2 2 0 Bacterial cadherin-like domain DDE_3 PF13358.6 KII69795.1 - 3.9e-21 75.4 0.1 1.9e-14 53.7 0.1 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease Wzy_C PF04932.15 KII69795.1 - 0.17 11.5 0.1 0.2 11.3 0.1 1.3 1 1 0 1 1 1 0 O-Antigen ligase SNAP PF14938.6 KII69801.1 - 7.6e-08 32.1 1.4 9.1e-08 31.9 1.4 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 KII69801.1 - 0.00016 21.4 1.8 0.06 13.4 0.3 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat NSF PF02071.20 KII69801.1 - 0.00068 19.9 2.6 2.1 9.4 0.4 4.1 3 1 1 4 4 4 1 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.17 KII69801.1 - 0.025 14.7 13.4 0.19 11.9 0.7 4.6 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KII69801.1 - 0.026 14.8 1.5 0.094 13.0 1.3 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat HSCB_C PF07743.13 KII69801.1 - 0.047 14.2 1.9 0.15 12.5 1.2 2.2 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain TPR_6 PF13174.6 KII69801.1 - 0.096 13.4 2.5 0.55 11.0 0.4 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII69801.1 - 0.12 12.2 0.8 0.12 12.2 0.8 4.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII69801.1 - 0.24 11.7 10.5 1.2 9.5 2.7 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 KII69801.1 - 4.4 7.3 6.8 3.1 7.8 0.2 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF1947 PF09183.10 KII69803.1 - 0.086 13.1 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) Folliculin_C PF16692.5 KII69804.1 - 0.091 12.5 1.0 0.12 12.0 1.0 1.3 1 1 0 1 1 1 0 Folliculin C-terminal domain Ndufs5 PF10200.9 KII69806.1 - 0.032 14.5 3.0 0.045 14.0 3.0 1.2 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa TPR_7 PF13176.6 KII69806.1 - 0.037 14.1 0.3 1.1 9.4 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat EF1G PF00647.19 KII69806.1 - 0.043 13.9 1.6 0.055 13.5 1.6 1.3 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain TPR_2 PF07719.17 KII69806.1 - 7.1 7.0 8.4 5.2 7.4 0.3 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DDE_3 PF13358.6 KII69808.1 - 1.7e-08 34.4 0.2 2e-08 34.1 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease RVT_1 PF00078.27 KII69812.1 - 0.0028 17.2 0.0 0.011 15.3 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3053 PF11254.8 KII69815.1 - 0.015 14.9 0.1 0.019 14.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) SNAP PF14938.6 KII69816.1 - 3e-10 40.0 0.6 4.1e-10 39.6 0.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII69816.1 - 0.031 14.5 3.7 2.7 8.4 0.0 3.4 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII69816.1 - 0.05 13.4 2.5 6.2 6.8 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 KII69816.1 - 0.073 13.4 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat rve PF00665.26 KII69817.1 - 9.5e-07 29.0 0.0 1.3e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain TarS_C1 PF18674.1 KII69824.1 - 0.23 11.4 4.6 0.24 11.3 0.3 2.3 2 1 0 2 2 2 0 TarS beta-glycosyltransferase C-terminal domain 1 DDE_3 PF13358.6 KII69826.1 - 2.3e-12 46.9 0.0 7.6e-12 45.2 0.0 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII69826.1 - 1e-06 28.3 0.2 2.3e-06 27.2 0.2 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 KII69826.1 - 1.7e-05 24.8 0.0 2.9e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 KII69826.1 - 0.0013 19.4 0.0 0.059 14.0 0.0 2.3 1 1 1 2 2 2 2 Homeodomain-like domain Bot1p PF12298.8 KII69826.1 - 0.0017 18.6 0.2 0.0089 16.2 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein BRX PF08381.11 KII69826.1 - 0.0033 16.8 0.4 0.02 14.2 0.1 2.3 2 1 0 2 2 2 1 Transcription factor regulating root and shoot growth via Pin3 HTH_28 PF13518.6 KII69826.1 - 0.013 15.7 0.2 0.046 13.8 0.2 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 KII69826.1 - 0.1 12.6 0.0 0.46 10.5 0.0 2.1 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain RT_RNaseH_2 PF17919.1 KII69827.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Kunitz_BPTI PF00014.23 KII69828.1 - 4.1e-05 23.7 13.9 0.0016 18.6 7.3 2.4 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain zf-C2H2_3rep PF18868.1 KII69830.1 - 0.09 13.5 0.6 0.09 13.5 0.6 2.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats DUF5137 PF17220.3 KII69830.1 - 0.14 13.1 2.9 0.27 12.1 2.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF5137) zf-C2H2_jaz PF12171.8 KII69830.1 - 1.7 9.0 7.5 79 3.7 7.5 2.7 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Cauli_AT PF03233.13 KII69831.1 - 0.09 12.7 4.3 0.081 12.9 1.8 1.9 2 0 0 2 2 2 0 Aphid transmission protein Cys_rich_CWC PF14375.6 KII69831.1 - 0.19 12.1 1.5 0.35 11.3 1.5 1.4 1 0 0 1 1 1 0 Cysteine-rich CWC zf-C2H2_jaz PF12171.8 KII69833.1 - 0.033 14.5 0.3 0.11 12.8 0.3 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding tRNA-synt_His PF13393.6 KII69834.1 - 0.084 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Histidyl-tRNA synthetase zf-CCHC PF00098.23 KII69835.1 - 0.0011 19.0 1.2 0.0011 19.0 1.2 2.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 KII69835.1 - 0.0014 18.5 13.9 0.076 13.0 1.2 2.4 1 1 1 2 2 2 2 Zinc knuckle DUF1192 PF06698.11 KII69835.1 - 0.037 14.1 2.1 0.38 10.8 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) FlaC_arch PF05377.11 KII69835.1 - 0.15 12.5 0.4 0.15 12.5 0.4 1.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) zf-CCHC_4 PF14392.6 KII69835.1 - 0.31 10.8 12.5 1.1 9.0 0.7 2.6 2 0 0 2 2 2 0 Zinc knuckle Bac_RepA_C PF18008.1 KII69837.1 - 0.035 14.5 0.3 0.062 13.7 0.3 1.4 1 0 0 1 1 1 0 Replication initiator protein A C-terminal domain G_glu_transpept PF01019.21 KII69837.1 - 0.23 10.2 0.0 0.29 9.8 0.0 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase EF-hand_5 PF13202.6 KII69841.1 - 2.9e-05 23.4 0.2 7.2e-05 22.1 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 KII69841.1 - 4.1e-05 22.8 1.7 0.00033 20.0 0.4 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KII69841.1 - 0.0015 18.3 0.2 0.0055 16.5 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KII69841.1 - 0.004 17.6 0.8 0.012 16.0 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KII69841.1 - 0.02 14.7 0.7 0.13 12.2 0.1 2.4 2 1 0 2 2 2 0 EF-hand domain pair DUF2779 PF11074.8 KII69841.1 - 0.11 13.0 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function(DUF2779) MYT1 PF08474.11 KII69844.1 - 0.12 12.3 0.0 0.89 9.4 0.0 1.9 1 1 1 2 2 2 0 Myelin transcription factor 1 DDE_3 PF13358.6 KII69847.1 - 4.1e-11 42.8 0.2 4.6e-09 36.2 0.3 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease Corona_NS8 PF12093.8 KII69848.1 - 0.028 15.0 0.1 0.074 13.6 0.1 1.6 2 0 0 2 2 2 0 Coronavirus NS8 protein Presenilin PF01080.17 KII69848.1 - 6.3 5.5 5.4 7.1 5.3 5.4 1.1 1 0 0 1 1 1 0 Presenilin DDE_Tnp_IS1595 PF12762.7 KII69849.1 - 3.3e-17 62.9 0.0 5.6e-17 62.2 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII69851.1 - 1.6e-21 76.6 0.0 2.2e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease LRRFIP PF09738.9 KII69852.1 - 0.049 13.1 3.0 0.066 12.7 3.0 1.1 1 0 0 1 1 1 0 LRRFIP family DDE_Tnp_IS1595 PF12762.7 KII69853.1 - 0.079 13.0 0.0 0.57 10.2 0.0 2.1 2 0 0 2 2 2 0 ISXO2-like transposase domain AAA_lid_5 PF17865.1 KII69854.1 - 0.0013 18.8 0.9 0.017 15.2 0.1 3.3 2 2 1 3 3 3 1 Midasin AAA lid domain DUF3161 PF11362.8 KII69854.1 - 0.0031 17.5 0.3 3.6 7.6 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3161) DASH_Dam1 PF08653.10 KII69854.1 - 3.6 7.5 6.1 15 5.5 0.0 4.0 4 0 0 4 4 4 0 DASH complex subunit Dam1 Cas_Cmr5 PF09701.10 KII69858.1 - 0.03 14.6 0.1 0.053 13.8 0.1 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cmr5) B2 PF11473.8 KII69858.1 - 0.084 12.7 0.2 9.1 6.2 0.0 2.6 1 1 2 3 3 3 0 RNA binding protein B2 Intron_maturas2 PF01348.21 KII69859.1 - 0.081 12.9 0.2 0.099 12.6 0.2 1.2 1 0 0 1 1 1 0 Type II intron maturase HTH_23 PF13384.6 KII69860.1 - 1e-10 41.1 0.3 6.6e-08 32.1 0.0 3.1 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.6 KII69860.1 - 5e-09 36.2 0.0 1.2e-07 31.7 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII69860.1 - 1.5e-07 31.6 3.9 9.9e-06 25.7 0.1 2.2 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.6 KII69860.1 - 5.5e-07 30.1 0.2 1.2e-05 25.8 0.1 2.0 1 1 1 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.6 KII69860.1 - 3.5e-06 26.5 2.5 0.0024 17.4 0.1 2.9 2 1 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_29 PF13551.6 KII69860.1 - 3.7e-06 26.9 0.1 8.7e-05 22.5 0.0 2.4 2 1 1 3 3 3 1 Winged helix-turn helix PAX PF00292.18 KII69860.1 - 2e-05 24.5 0.2 2.5e-05 24.2 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain Rrf2 PF02082.20 KII69860.1 - 0.00015 22.0 0.1 0.00036 20.8 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulator MerR PF00376.23 KII69860.1 - 0.00016 21.4 0.1 0.43 10.4 0.0 3.5 3 1 0 3 3 3 1 MerR family regulatory protein HTH_Tnp_1 PF01527.20 KII69860.1 - 0.00017 21.8 0.2 0.00029 21.1 0.2 1.5 1 0 0 1 1 1 1 Transposase Phage_int_SAM_6 PF18644.1 KII69860.1 - 0.00026 21.0 3.7 0.00071 19.6 3.7 1.6 1 1 0 1 1 1 1 Phage integrase SAM-like domain MarR_2 PF12802.7 KII69860.1 - 0.00033 20.5 0.0 0.00074 19.3 0.0 1.6 1 0 0 1 1 1 1 MarR family MerR_1 PF13411.6 KII69860.1 - 0.00054 20.0 0.8 0.39 10.8 0.1 3.6 1 1 2 3 3 3 1 MerR HTH family regulatory protein FeoC PF09012.10 KII69860.1 - 0.001 19.1 0.7 0.023 14.7 0.1 2.5 2 1 1 3 3 3 1 FeoC like transcriptional regulator HTH_17 PF12728.7 KII69860.1 - 0.0011 19.1 0.8 9.1 6.6 0.0 3.6 4 0 0 4 4 3 0 Helix-turn-helix domain HTH_11 PF08279.12 KII69860.1 - 0.0014 18.6 6.1 0.44 10.5 1.7 3.2 2 2 0 2 2 2 2 HTH domain HTH_36 PF13730.6 KII69860.1 - 0.0024 17.8 1.6 14 5.7 0.1 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain CENP-B_N PF04218.13 KII69860.1 - 0.003 17.1 1.3 0.0089 15.6 0.1 2.3 2 1 1 3 3 3 1 CENP-B N-terminal DNA-binding domain TnsD PF15978.5 KII69860.1 - 0.0041 16.1 3.5 0.0047 16.0 3.5 1.2 1 0 0 1 1 1 1 Tn7-like transposition protein D HTH_33 PF13592.6 KII69860.1 - 0.0057 16.3 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 KII69860.1 - 0.0062 15.9 0.1 0.015 14.7 0.0 1.8 2 0 0 2 2 1 1 Helix-turn-helix domain of transposase family ISL3 HHH_4 PF14490.6 KII69860.1 - 0.01 15.8 0.0 0.079 13.0 0.0 2.1 1 1 0 1 1 1 0 Helix-hairpin-helix containing domain HTH_38 PF13936.6 KII69860.1 - 0.011 15.5 3.4 0.077 12.8 0.1 2.9 3 1 1 4 4 4 0 Helix-turn-helix domain HTH_27 PF13463.6 KII69860.1 - 0.021 15.3 0.4 0.064 13.8 0.1 2.0 2 1 0 2 2 1 0 Winged helix DNA-binding domain Fe_dep_repress PF01325.19 KII69860.1 - 0.028 14.6 0.6 0.18 12.0 0.1 2.4 2 1 1 3 3 3 0 Iron dependent repressor, N-terminal DNA binding domain HTH_10 PF04967.12 KII69860.1 - 0.037 13.8 0.4 4.6 7.1 0.0 2.9 3 1 0 3 3 2 0 HTH DNA binding domain HTH_5 PF01022.20 KII69860.1 - 0.042 13.7 0.6 0.79 9.6 0.0 2.5 3 0 0 3 3 2 0 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 KII69860.1 - 0.052 13.6 0.0 2.3 8.3 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HARE-HTH PF05066.13 KII69860.1 - 0.056 13.8 0.2 2 8.9 0.0 2.4 2 1 0 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain HTH_Tnp_1_2 PF13022.6 KII69860.1 - 0.063 13.4 0.6 0.29 11.3 0.2 1.9 1 1 0 2 2 2 0 Helix-turn-helix of insertion element transposase HTH_19 PF12844.7 KII69860.1 - 0.066 13.3 1.7 2 8.5 1.3 2.5 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.22 KII69860.1 - 0.066 13.3 1.2 1.3 9.2 0.1 3.0 2 2 2 4 4 4 0 Helix-turn-helix HTH_18 PF12833.7 KII69860.1 - 0.089 13.1 0.1 1.4 9.3 0.0 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.16 KII69860.1 - 0.2 11.7 4.8 0.51 10.4 4.4 1.8 1 1 0 1 1 1 0 Transposase LacI PF00356.21 KII69860.1 - 0.61 9.9 2.9 21 5.0 1.5 3.3 3 1 0 4 4 4 0 Bacterial regulatory proteins, lacI family E1_DerP2_DerF2 PF02221.15 KII69861.1 - 3.5e-08 34.0 1.1 4.6e-08 33.6 1.1 1.1 1 0 0 1 1 1 1 ML domain tRNA_lig_CPD PF08302.11 KII69862.1 - 0.013 14.9 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain rve PF00665.26 KII69863.1 - 5.4e-20 71.8 0.0 7.8e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII69863.1 - 1.2e-05 24.9 0.0 2.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII69863.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease RVP_2 PF08284.11 KII69864.1 - 8.3e-09 35.3 0.0 1.6e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII69864.1 - 4.9e-07 30.2 0.0 1.3e-06 28.8 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII69864.1 - 9.4e-07 28.7 0.1 3.2e-06 26.9 0.1 1.8 1 1 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII69864.1 - 1.1e-05 25.7 0.0 2.4e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII69864.1 - 9.5e-05 23.0 0.0 0.00025 21.6 0.0 1.7 1 1 0 1 1 1 1 Aspartyl protease Peptidase_A3 PF02160.15 KII69864.1 - 0.0074 15.8 0.1 0.015 14.8 0.1 1.4 1 0 0 1 1 1 1 Cauliflower mosaic virus peptidase (A3) zf-CCHC_4 PF14392.6 KII69864.1 - 0.019 14.7 2.1 0.045 13.5 2.1 1.7 1 0 0 1 1 1 0 Zinc knuckle FYVE_2 PF02318.16 KII69864.1 - 0.046 13.9 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger RVT_1 PF00078.27 KII69864.1 - 0.14 11.7 0.3 0.24 10.9 0.3 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_6 PF15288.6 KII69864.1 - 0.21 11.5 4.8 0.49 10.3 4.8 1.6 1 0 0 1 1 1 0 Zinc knuckle UBN_AB PF14075.6 KII69866.1 - 0.044 13.5 1.3 0.077 12.7 0.3 1.9 1 1 0 2 2 2 0 Ubinuclein conserved middle domain Flu_NS1 PF00600.19 KII69867.1 - 0.026 14.1 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 Influenza non-structural protein (NS1) Chalcone PF02431.15 KII69867.1 - 0.065 12.6 0.2 0.22 10.9 0.0 1.9 2 0 0 2 2 2 0 Chalcone-flavanone isomerase Cu_bind_like PF02298.17 KII69868.1 - 0.059 13.4 2.9 16 5.6 0.1 3.0 1 1 2 3 3 3 0 Plastocyanin-like domain HCV_env PF01539.17 KII69868.1 - 0.36 10.5 6.7 0.92 9.2 1.3 2.1 1 1 1 2 2 2 0 Hepatitis C virus envelope glycoprotein E1 Orf78 PF06024.12 KII69871.1 - 0.0015 18.8 0.1 0.0017 18.6 0.1 1.3 1 0 0 1 1 1 1 Orf78 (ac78) DUF4366 PF14283.6 KII69871.1 - 0.0015 18.6 0.0 0.0015 18.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) RIFIN PF02009.16 KII69871.1 - 0.0059 16.5 0.1 0.0069 16.3 0.1 1.1 1 0 0 1 1 1 1 Rifin DUF5305 PF17231.2 KII69871.1 - 0.0072 15.8 0.2 0.0084 15.5 0.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5305) LRRC37AB_C PF14914.6 KII69871.1 - 0.0096 15.8 0.3 0.011 15.6 0.3 1.2 1 0 0 1 1 1 1 LRRC37A/B like protein 1 C-terminal domain DUF3377 PF11857.8 KII69871.1 - 0.015 15.2 0.3 0.021 14.8 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DAG1 PF05454.11 KII69871.1 - 0.023 14.1 0.1 0.023 14.1 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) CD34_antigen PF06365.12 KII69871.1 - 0.025 14.2 0.1 0.026 14.1 0.1 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family Neurensin PF14927.6 KII69871.1 - 0.055 13.2 0.2 0.081 12.6 0.2 1.2 1 0 0 1 1 1 0 Neurensin TMEM154 PF15102.6 KII69871.1 - 0.079 12.9 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF872 PF05915.12 KII69871.1 - 0.085 13.0 0.4 0.14 12.3 0.2 1.4 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) SCAI PF12070.8 KII69872.1 - 0.0032 16.4 0.5 0.0033 16.4 0.5 1.1 1 0 0 1 1 1 1 Protein SCAI zf-CCHC PF00098.23 KII69873.1 - 2.2e-06 27.4 10.7 1.4e-05 24.9 1.8 2.5 2 0 0 2 2 2 2 Zinc knuckle RVP_2 PF08284.11 KII69873.1 - 0.011 15.5 0.1 0.026 14.3 0.1 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII69873.1 - 0.015 15.8 0.1 0.037 14.6 0.1 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII69873.1 - 0.04 14.2 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 KII69873.1 - 0.056 13.2 7.1 1.6 8.5 0.5 2.5 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII69873.1 - 0.13 12.4 0.0 0.39 10.8 0.0 1.9 1 1 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_2 PF13696.6 KII69873.1 - 0.78 9.6 11.1 2.8 7.9 0.7 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 KII69873.1 - 2.5 8.1 8.5 1.4 9.0 0.7 2.6 1 1 1 2 2 2 0 Zinc knuckle Actin PF00022.19 KII69874.1 - 3.7e-151 503.4 0.0 1.2e-150 501.7 0.0 1.6 1 1 0 1 1 1 1 Actin MMS1_N PF10433.9 KII69875.1 - 2.3e-154 514.7 0.0 1.9e-153 511.6 0.0 2.1 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KII69875.1 - 8.5e-80 268.5 0.0 7.2e-78 262.1 0.0 2.3 2 0 0 2 2 2 2 CPSF A subunit region Rota_NSP3 PF01665.16 KII69878.1 - 0.0055 15.9 0.1 0.0066 15.6 0.1 1.2 1 0 0 1 1 1 1 Rotavirus non-structural protein NSP3 DDE_Tnp_IS1595 PF12762.7 KII69878.1 - 0.019 15.0 0.1 0.053 13.5 0.1 1.7 1 1 0 1 1 1 0 ISXO2-like transposase domain zf-Sec23_Sec24 PF04810.15 KII69880.1 - 0.032 14.3 0.2 0.078 13.0 0.2 1.7 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger HTH_25 PF13413.6 KII69881.1 - 0.21 11.5 0.1 0.48 10.3 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain rve_3 PF13683.6 KII69882.1 - 9.6e-06 25.3 0.5 1.8e-05 24.4 0.5 1.4 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 KII69882.1 - 0.00027 21.1 0.1 0.00063 19.9 0.1 1.6 1 1 0 1 1 1 1 Integrase core domain Sigma70_r1_1 PF03979.14 KII69883.1 - 0.031 14.3 1.5 0.064 13.3 0.4 2.1 2 1 0 2 2 2 0 Sigma-70 factor, region 1.1 RNA_pol_Rpb5_C PF01191.19 KII69883.1 - 0.14 12.0 0.2 2.2 8.2 0.0 2.5 1 1 1 2 2 2 0 RNA polymerase Rpb5, C-terminal domain HTH_Tnp_Tc3_2 PF01498.18 KII69884.1 - 0.077 13.3 0.4 0.18 12.1 0.1 1.7 2 0 0 2 2 2 0 Transposase EGF_2 PF07974.13 KII69885.1 - 0.0015 18.8 1.5 0.0015 18.8 1.5 2.9 2 1 1 3 3 3 2 EGF-like domain DSL PF01414.19 KII69885.1 - 0.067 13.5 13.9 0.18 12.1 13.9 1.8 1 0 0 1 1 1 0 Delta serrate ligand DDE_Tnp_IS1595 PF12762.7 KII69888.1 - 2.5e-08 34.0 0.0 3.2e-08 33.7 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain Cystatin PF00031.21 KII69890.1 - 0.0039 17.4 0.0 0.014 15.6 0.0 1.9 1 1 0 1 1 1 1 Cystatin domain SnoaL PF07366.12 KII69890.1 - 0.06 13.2 0.0 0.073 12.9 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase Flavi_NS1 PF00948.21 KII69890.1 - 0.15 10.9 0.0 0.15 10.9 0.0 1.0 1 0 0 1 1 1 0 Flavivirus non-structural Protein NS1 gag-asp_proteas PF13975.6 KII69892.1 - 0.0079 16.7 0.0 0.063 13.8 0.0 2.4 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII69892.1 - 0.0083 16.4 0.0 0.024 14.9 0.0 1.7 1 1 0 1 1 1 1 Retroviral aspartyl protease T6PP_N PF18572.1 KII69893.1 - 0.037 13.8 0.1 0.076 12.9 0.1 1.5 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain SIS PF01380.22 KII69894.1 - 1.8e-41 141.0 0.4 1.8e-25 89.3 0.0 2.1 2 0 0 2 2 2 2 SIS domain SIS_2 PF13580.6 KII69894.1 - 0.008 16.2 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 SIS domain Zmiz1_N PF18028.1 KII69895.1 - 0.071 13.4 0.0 0.16 12.3 0.0 1.6 1 1 0 1 1 1 0 Zmiz1 N-terminal tetratricopeptide repeat domain Galactosyl_T PF01762.21 KII69896.1 - 1.4e-28 100.0 1.2 2.6e-28 99.2 1.2 1.4 1 0 0 1 1 1 1 Galactosyltransferase Glyco_tranf_2_3 PF13641.6 KII69896.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DUF4371 PF14291.6 KII69897.1 - 3.2e-05 23.7 0.0 3.9e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DUF659 PF04937.15 KII69897.1 - 0.0031 17.4 0.1 0.0041 17.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) DUF4371 PF14291.6 KII69898.1 - 0.02 14.6 0.0 0.037 13.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4371) Phage_HK97_TLTM PF06120.11 KII69899.1 - 0.0067 15.6 0.0 0.0085 15.3 0.0 1.0 1 0 0 1 1 1 1 Tail length tape measure protein Cystatin PF00031.21 KII69899.1 - 0.016 15.5 0.0 0.022 15.0 0.0 1.4 1 1 0 1 1 1 0 Cystatin domain Trp_DMAT PF11991.8 KII69899.1 - 0.021 14.3 0.0 0.023 14.1 0.0 1.0 1 0 0 1 1 1 0 Tryptophan dimethylallyltransferase Cation_ATPase_N PF00690.26 KII69899.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Cystatin PF00031.21 KII69900.1 - 0.0087 16.3 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Cystatin domain DUF3895 PF13034.6 KII69901.1 - 0.12 12.4 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3895) zf-TFIIB PF13453.6 KII69902.1 - 1.7 8.0 5.4 2.9 7.3 5.4 1.4 1 0 0 1 1 1 0 Transcription factor zinc-finger DDE_Tnp_IS1595 PF12762.7 KII69903.1 - 5.2e-14 52.5 0.1 5.4e-14 52.5 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain ABC_tran PF00005.27 KII69904.1 - 1.1e-42 145.8 1.1 2.5e-21 76.6 0.0 3.3 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 KII69904.1 - 1.1e-16 61.6 9.9 0.00017 21.5 0.0 4.4 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 KII69904.1 - 1.2e-15 57.2 0.2 1.2e-15 57.2 0.2 2.6 3 0 0 3 3 3 1 ABC transporter SMC_N PF02463.19 KII69904.1 - 9.9e-13 48.0 2.8 0.00028 20.4 0.0 4.6 3 1 2 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KII69904.1 - 1.3e-07 31.3 0.9 0.00091 18.9 0.2 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 KII69904.1 - 2.5e-05 24.2 16.3 0.018 14.7 0.3 4.7 4 1 0 4 4 4 2 AAA ATPase domain NACHT PF05729.12 KII69904.1 - 3.7e-05 23.7 0.2 0.045 13.7 0.0 2.8 3 0 0 3 3 2 2 NACHT domain RsgA_GTPase PF03193.16 KII69904.1 - 4.1e-05 23.5 0.1 0.016 15.1 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 KII69904.1 - 0.00017 21.4 0.0 4.5 6.9 0.0 3.7 3 1 0 3 3 3 1 AAA domain AAA_23 PF13476.6 KII69904.1 - 0.00025 21.6 19.7 0.023 15.2 0.3 4.3 4 1 0 4 4 4 2 AAA domain MMR_HSR1 PF01926.23 KII69904.1 - 0.00091 19.3 0.2 0.29 11.2 0.1 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KII69904.1 - 0.0011 19.3 0.1 0.6 10.4 0.1 3.0 3 1 0 3 3 2 1 AAA domain AAA_24 PF13479.6 KII69904.1 - 0.0016 18.2 1.8 1.2 8.8 0.1 3.0 3 0 0 3 3 2 2 AAA domain NB-ARC PF00931.22 KII69904.1 - 0.0066 15.7 0.9 2.3 7.3 0.0 3.1 4 0 0 4 4 4 1 NB-ARC domain T2SSE PF00437.20 KII69904.1 - 0.007 15.4 1.0 0.015 14.4 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein TsaE PF02367.17 KII69904.1 - 0.0081 16.2 0.0 1.1 9.3 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 KII69904.1 - 0.0081 16.6 0.0 1.6 9.1 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain Pox_A_type_inc PF04508.12 KII69904.1 - 0.0082 15.9 1.1 0.026 14.4 1.1 1.8 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat AAA PF00004.29 KII69904.1 - 0.0085 16.5 0.5 10 6.5 0.0 3.6 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KII69904.1 - 0.02 14.9 0.1 9.1 6.3 0.0 3.5 3 0 0 3 3 2 0 AAA domain AAA_19 PF13245.6 KII69904.1 - 0.027 14.8 0.0 4.1 7.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 KII69904.1 - 0.027 14.7 0.1 1.2 9.4 0.0 3.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 KII69904.1 - 0.049 13.5 2.1 4.3 7.2 0.0 3.0 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 KII69904.1 - 0.079 13.5 0.0 3.7 8.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KII69904.1 - 0.081 13.3 0.0 6.1 7.3 0.0 2.7 2 0 0 2 2 2 0 RNA helicase PduV-EutP PF10662.9 KII69904.1 - 0.1 12.4 0.1 12 5.6 0.1 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 KII69904.1 - 0.1 11.9 0.1 0.84 8.9 0.1 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF2948 PF11164.8 KII69904.1 - 0.11 12.5 2.2 1.6 8.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2948) NTPase_1 PF03266.15 KII69904.1 - 0.15 11.9 0.7 5.4 6.9 0.1 2.6 2 0 0 2 2 2 0 NTPase AAA_28 PF13521.6 KII69904.1 - 0.16 12.2 0.1 13 6.0 0.3 2.6 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 KII69904.1 - 0.19 11.7 0.7 9.9 6.1 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Roc PF08477.13 KII69904.1 - 0.36 11.1 3.8 2.6 8.3 0.1 3.0 4 0 0 4 4 2 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 KII69904.1 - 1.3 9.1 8.0 0.33 11.0 0.3 3.2 3 0 0 3 3 3 0 Helicase HerA, central domain DDE_3 PF13358.6 KII69905.1 - 2e-11 43.8 0.1 3.6e-11 43.0 0.1 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease NT5C PF06941.12 KII69905.1 - 0.071 13.0 0.0 0.088 12.7 0.0 1.3 1 1 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) V-ATPase_C PF03223.15 KII69907.1 - 0.057 12.8 0.3 0.087 12.2 0.3 1.2 1 0 0 1 1 1 0 V-ATPase subunit C DDE_Tnp_IS1595 PF12762.7 KII69908.1 - 7.8e-09 35.7 0.0 1.2e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain ACP_PD PF04336.12 KII69909.1 - 0.059 13.8 0.2 0.24 11.8 0.0 2.0 2 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase Phage_tail_T PF06223.12 KII69909.1 - 0.073 13.6 0.4 0.14 12.7 0.1 1.6 2 0 0 2 2 2 0 Minor tail protein T RT_RNaseH PF17917.1 KII69912.1 - 0.041 14.2 0.0 0.28 11.5 0.0 2.0 1 1 1 2 2 2 0 RNase H-like domain found in reverse transcriptase Njmu-R1 PF15053.6 KII69915.1 - 0.04 13.0 0.0 0.052 12.7 0.0 1.1 1 0 0 1 1 1 0 Mjmu-R1-like protein family Prok-RING_4 PF14447.6 KII69916.1 - 0.00089 19.1 1.4 0.0017 18.1 1.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 KCNQC3-Ank-G_bd PF11956.8 KII69916.1 - 0.014 15.7 0.1 0.22 11.8 0.0 2.2 2 0 0 2 2 2 0 Ankyrin-G binding motif of KCNQ2-3 zf-C3HC4_3 PF13920.6 KII69916.1 - 0.021 14.7 1.0 0.034 14.0 1.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zinc-ribbons_6 PF07191.12 KII69916.1 - 0.035 14.1 1.0 0.055 13.4 1.0 1.4 1 0 0 1 1 1 0 zinc-ribbons Zn-ribbon_8 PF09723.10 KII69916.1 - 0.097 12.8 2.7 0.19 11.8 2.7 1.4 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_9 PF14369.6 KII69916.1 - 0.35 11.2 4.7 0.64 10.3 4.0 1.8 2 0 0 2 2 2 0 zinc-ribbon DUF4096 PF13340.6 KII69917.1 - 0.079 13.2 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Putative transposase of IS4/5 family (DUF4096) Retrotrans_gag PF03732.17 KII69918.1 - 5.2e-05 23.4 0.0 0.00012 22.2 0.0 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 KII69918.1 - 0.003 17.6 2.9 0.003 17.6 2.9 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.6 KII69918.1 - 0.029 14.1 1.5 0.029 14.1 1.5 1.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 KII69918.1 - 0.041 13.6 1.1 0.095 12.4 1.1 1.6 1 0 0 1 1 1 0 Zinc knuckle Peptidase_C1 PF00112.23 KII69919.1 - 5.4e-44 150.9 0.0 7.7e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII69919.1 - 2.2e-09 37.6 3.0 3.8e-09 36.8 3.0 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF1497 PF07384.11 KII69920.1 - 0.04 14.3 0.0 0.071 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1497) RVT_1 PF00078.27 KII69921.1 - 0.00018 21.1 0.0 0.00021 20.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DAGK_cat PF00781.24 KII69923.1 - 0.018 14.6 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain EMC3_TMCO1 PF01956.16 KII69924.1 - 2.6e-16 59.8 3.1 2.9e-16 59.7 3.1 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DDE_Tnp_IS1595 PF12762.7 KII69925.1 - 1.1e-16 61.2 0.0 2e-16 60.3 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain zf-tcix PF14952.6 KII69925.1 - 0.035 13.7 0.5 0.035 13.7 0.5 1.8 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding Inhibitor_I29 PF08246.12 KII69926.1 - 6.4e-10 39.3 4.8 8.9e-10 38.9 4.8 1.2 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.23 KII69926.1 - 2.8e-08 34.1 0.4 1.3e-07 31.9 0.0 1.9 2 0 0 2 2 2 1 Papain family cysteine protease Peptidase_C1 PF00112.23 KII69927.1 - 6.8e-55 186.5 0.1 3.2e-30 105.8 0.0 2.5 2 1 1 3 3 3 2 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII69927.1 - 2.1e-09 37.7 4.8 3.5e-09 36.9 4.8 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KII69927.1 - 0.00075 18.4 0.2 0.0049 15.7 0.1 2.1 2 1 0 2 2 2 1 Peptidase C1-like family Peptidase_C1 PF00112.23 KII69928.1 - 1.4e-35 123.4 0.0 3.7e-35 122.0 0.0 1.7 2 1 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII69928.1 - 6.6e-11 42.5 7.4 1.1e-10 41.8 7.4 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) HGTP_anticodon PF03129.20 KII69929.1 - 1.5e-20 73.1 0.0 3.3e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Thiamine_BP PF01910.17 KII69929.1 - 0.047 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Thiamine-binding protein PilJ_C PF18223.1 KII69929.1 - 0.057 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Pili PilJ C-terminal domain Sin3a_C PF16879.5 KII69930.1 - 0.012 15.4 3.0 0.012 15.3 3.0 1.0 1 0 0 1 1 1 0 C-terminal domain of Sin3a protein SpoIIE PF07228.12 KII69930.1 - 0.035 14.0 0.1 0.037 13.9 0.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) NBP1 PF08537.10 KII69930.1 - 0.12 11.8 6.9 0.13 11.7 6.9 1.1 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DDE_3 PF13358.6 KII69931.1 - 4.3e-11 42.8 0.0 6.4e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease MTBP_mid PF14919.6 KII69931.1 - 0.059 12.6 0.0 0.062 12.5 0.0 1.0 1 0 0 1 1 1 0 MDM2-binding DDE_Tnp_ISAZ013 PF07592.11 KII69931.1 - 0.2 10.6 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DDE_1 PF03184.19 KII69932.1 - 5e-14 52.3 0.0 6.9e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease NBD94 PF16830.5 KII69932.1 - 0.018 15.4 0.2 0.048 14.0 0.0 1.8 1 1 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH DUF4914 PF16260.5 KII69933.1 - 0.033 12.3 0.1 0.042 12.0 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4914) WSC PF01822.19 KII69935.1 - 1.5e-12 47.6 5.6 1.5e-12 47.6 5.6 3.3 3 0 0 3 3 3 2 WSC domain Resistin PF06954.11 KII69935.1 - 9.1 6.9 24.1 2.5 8.7 0.3 4.5 4 0 0 4 4 4 0 Resistin WD40 PF00400.32 KII69936.1 - 0.012 16.4 11.2 0.09 13.7 0.5 4.3 3 1 1 4 4 4 0 WD domain, G-beta repeat PQQ_3 PF13570.6 KII69936.1 - 0.087 13.3 0.1 0.38 11.3 0.0 2.0 2 0 0 2 2 2 0 PQQ-like domain RNA_pol_Rpb6 PF01192.22 KII69937.1 - 1.4e-16 60.1 0.2 2.4e-16 59.4 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 DDE_1 PF03184.19 KII69938.1 - 4.1e-05 23.3 0.0 6.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease IU_nuc_hydro PF01156.19 KII69941.1 - 8.2e-39 134.0 0.0 9.4e-39 133.8 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Glycos_transf_2 PF00535.26 KII69942.1 - 0.12 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 SepSecS PF05889.13 KII69943.1 - 4.5e-98 328.5 0.0 6e-98 328.1 0.0 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 KII69943.1 - 2.7e-05 23.6 0.0 3.5e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 KII69943.1 - 0.00019 20.7 0.0 0.00028 20.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Band_7 PF01145.25 KII69944.1 - 0.076 13.0 0.3 0.12 12.3 0.3 1.3 1 1 0 1 1 1 0 SPFH domain / Band 7 family FLYWCH PF04500.16 KII69945.1 - 3e-10 40.0 0.3 6.7e-10 38.9 0.3 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII69945.1 - 0.00058 20.2 0.1 0.0012 19.2 0.1 1.5 1 0 0 1 1 1 1 MULE transposase domain H_lectin PF09458.10 KII69945.1 - 0.11 12.7 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 H-type lectin domain UBX PF00789.20 KII69947.1 - 2.7e-06 27.5 0.0 5.9e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain Peptidase_M48_N PF16491.5 KII69947.1 - 0.0036 17.2 0.0 0.0046 16.9 0.0 1.2 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices ubiquitin PF00240.23 KII69947.1 - 0.15 11.8 0.7 2.7 7.8 0.2 2.8 1 1 1 2 2 2 0 Ubiquitin family RT_RNaseH PF17917.1 KII69951.1 - 6.2e-32 110.0 0.0 1.4e-31 108.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII69951.1 - 3e-31 107.4 0.1 1.1e-30 105.6 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII69951.1 - 4e-27 95.2 0.0 1.1e-26 93.7 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII69951.1 - 2.7e-17 62.6 1.4 2.7e-17 62.6 1.4 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain RVP PF00077.20 KII69951.1 - 0.00039 20.7 0.0 0.001 19.3 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KII69951.1 - 0.002 17.9 1.2 0.0068 16.2 0.1 2.2 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII69951.1 - 0.0035 17.9 0.0 0.0089 16.6 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve PF00665.26 KII69951.1 - 0.014 15.6 0.1 0.075 13.2 0.0 2.4 3 0 0 3 3 3 0 Integrase core domain Asp_protease_2 PF13650.6 KII69951.1 - 0.021 15.4 0.0 0.044 14.4 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.6 KII69951.1 - 0.98 9.2 9.8 0.097 12.4 1.3 2.8 2 0 0 2 2 2 0 Zinc knuckle MFS_1 PF07690.16 KII69952.1 - 1.6e-33 116.1 18.9 4.3e-33 114.7 18.0 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KII69952.1 - 9.4e-12 44.5 23.8 3.5e-08 32.7 15.7 3.1 2 1 1 3 3 3 3 Sugar (and other) transporter Stealth_CR1 PF17101.5 KII69953.1 - 0.065 13.0 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 DUF2187 PF09953.9 KII69953.1 - 0.083 12.9 0.2 0.18 11.9 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2187) Lipocalin_3 PF12702.7 KII69953.1 - 0.085 12.9 1.0 6.4 6.9 0.0 2.2 1 1 1 2 2 2 0 Lipocalin-like PI3K_P85_iSH2 PF16454.5 KII69955.1 - 0.028 14.0 5.8 0.6 9.7 0.2 2.1 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Cauli_AT PF03233.13 KII69955.1 - 0.029 14.3 5.1 0.068 13.1 0.6 2.1 2 0 0 2 2 2 0 Aphid transmission protein Metallophos_3 PF14582.6 KII69955.1 - 0.042 13.2 0.1 0.052 12.9 0.1 1.1 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily THP2 PF09432.10 KII69955.1 - 0.62 10.1 7.9 1.9 8.6 1.6 2.3 1 1 1 2 2 2 0 Tho complex subunit THP2 Fib_alpha PF08702.10 KII69955.1 - 8.6 6.5 10.5 0.66 10.2 1.3 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DDE_Tnp_IS1595 PF12762.7 KII69958.1 - 2.1e-06 27.8 0.0 3.3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain TRAP_beta PF05753.14 KII69959.1 - 6.6e-23 81.0 0.2 7.2e-23 80.9 0.2 1.0 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DUF5436 PF17504.2 KII69959.1 - 0.056 13.8 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5436) DDE_3 PF13358.6 KII69960.1 - 2.7e-15 56.4 0.1 3.7e-15 56.0 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.11 KII69960.1 - 0.0043 16.1 0.0 0.0045 16.0 0.0 1.1 1 0 0 1 1 1 1 Rhodopirellula transposase DDE domain SAGA-Tad1 PF12767.7 KII69960.1 - 0.024 14.4 0.1 0.04 13.7 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit CHASE3 PF05227.13 KII69960.1 - 0.045 13.7 0.1 0.063 13.2 0.1 1.3 1 0 0 1 1 1 0 CHASE3 domain rve PF00665.26 KII69960.1 - 0.067 13.4 0.0 0.094 12.9 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain APH_6_hur PF04655.14 KII69960.1 - 0.17 11.2 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase CactinC_cactus PF09732.9 KII69961.1 - 5.4e-42 142.7 4.7 5.4e-42 142.7 4.7 1.8 2 0 0 2 2 2 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 KII69961.1 - 9.6e-20 71.2 2.3 1.6e-19 70.4 2.3 1.4 1 0 0 1 1 1 1 Conserved mid region of cactin DDE_Tnp_IS1595 PF12762.7 KII69962.1 - 5.5e-09 36.2 0.0 9.3e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_1 PF03184.19 KII69962.1 - 0.037 13.7 0.1 0.084 12.5 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease Transposase_mut PF00872.18 KII69963.1 - 0.013 14.4 0.7 0.018 13.9 0.7 1.2 1 0 0 1 1 1 0 Transposase, Mutator family Alfin PF12165.8 KII69963.1 - 0.062 13.0 0.1 0.085 12.5 0.1 1.2 1 0 0 1 1 1 0 Alfin PI-PLC-X PF00388.19 KII69964.1 - 1.9e-60 202.6 0.1 5.5e-60 201.2 0.1 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain EF-hand_like PF09279.11 KII69964.1 - 5e-12 46.2 2.2 1.4e-11 44.7 0.9 2.4 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like PH_14 PF17787.1 KII69964.1 - 0.0099 15.7 0.2 0.031 14.1 0.2 2.0 1 0 0 1 1 1 1 PH domain HMMR_N PF15905.5 KII69968.1 - 0.00091 18.8 5.7 0.0011 18.5 5.7 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal TMF_TATA_bd PF12325.8 KII69968.1 - 0.034 14.3 2.3 5.6 7.2 0.7 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 KII69968.1 - 0.045 12.6 4.7 0.29 10.0 3.2 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4200 PF13863.6 KII69968.1 - 0.26 11.7 7.1 0.17 12.3 5.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4795 PF16043.5 KII69968.1 - 0.77 9.3 6.9 1.4 8.5 6.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) YgaB PF14182.6 KII69968.1 - 0.78 10.2 9.3 0.41 11.1 4.2 2.7 1 1 2 3 3 3 0 YgaB-like protein RT_RNaseH PF17917.1 KII69971.1 - 1.5e-10 41.3 0.1 2.2e-10 40.8 0.1 1.4 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII69971.1 - 8.7e-08 32.1 0.1 2.7e-07 30.6 0.0 1.9 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase TACC_C PF05010.14 KII69974.1 - 7.3e-09 35.7 19.7 3.9e-08 33.3 19.7 2.1 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal PRKG1_interact PF15898.5 KII69974.1 - 0.0041 18.0 3.0 0.0041 18.0 3.0 3.7 2 1 3 5 5 4 1 cGMP-dependent protein kinase interacting domain DUF5595 PF18077.1 KII69974.1 - 0.0086 16.1 1.3 0.0086 16.1 1.3 3.9 3 1 1 4 4 4 1 Domain of unknown function (DUF5595) DUF1664 PF07889.12 KII69974.1 - 0.053 13.6 8.9 0.12 12.4 1.2 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) ING PF12998.7 KII69974.1 - 0.1 13.2 8.5 0.071 13.7 4.8 2.7 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Spc7 PF08317.11 KII69974.1 - 0.54 9.1 14.8 0.34 9.8 12.6 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 KII69974.1 - 1.2 8.4 8.3 1.3 8.3 6.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 KII69974.1 - 1.2 9.1 15.5 2 8.5 4.1 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Phage_Mu_Gam PF07352.12 KII69974.1 - 1.3 8.9 11.4 9.9 6.1 0.4 3.2 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein SIKE PF05769.11 KII69974.1 - 2.3 8.1 17.6 96 2.8 17.6 2.8 1 1 1 2 2 2 0 SIKE family Syntaxin-6_N PF09177.11 KII69974.1 - 4.3 8.0 10.7 11 6.7 6.7 3.4 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Fungal_TACC PF12709.7 KII69974.1 - 6.5 7.3 13.1 0.39 11.2 1.1 3.5 2 1 2 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins DDE_Tnp_IS1595 PF12762.7 KII69975.1 - 2.5e-06 27.6 0.0 3.1e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF3274 PF11678.8 KII69975.1 - 0.097 11.9 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3274) DUF747 PF05346.11 KII69976.1 - 5.2e-07 29.4 1.2 5.9e-07 29.3 0.5 1.4 1 1 0 1 1 1 1 Eukaryotic membrane protein family Rhamnogal_lyase PF06045.11 KII69976.1 - 0.053 12.9 0.3 0.061 12.7 0.3 1.2 1 0 0 1 1 1 0 Rhamnogalacturonate lyase family P_proprotein PF01483.20 KII69977.1 - 3.5e-05 23.7 0.1 8.7e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain MRP-L46 PF11788.8 KII69977.1 - 0.045 14.5 10.5 1.7 9.4 5.9 2.4 1 1 1 2 2 2 0 39S mitochondrial ribosomal protein L46 Ribosomal_S11 PF00411.19 KII69978.1 - 1.5e-46 157.3 1.1 1.9e-46 157.0 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 BKACE PF05853.12 KII69978.1 - 0.079 12.3 0.2 0.1 11.9 0.2 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme CBM_25 PF03423.13 KII69978.1 - 0.13 12.5 0.0 0.31 11.3 0.0 1.6 2 0 0 2 2 2 0 Carbohydrate binding domain (family 25) HTH_33 PF13592.6 KII69979.1 - 0.00059 19.4 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix DUF5409 PF17421.2 KII69980.1 - 0.036 14.8 0.2 0.078 13.7 0.2 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5409) rve PF00665.26 KII69983.1 - 5.4e-11 42.7 0.0 9.6e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII69983.1 - 0.00037 20.2 0.0 0.0007 19.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII69983.1 - 0.013 15.5 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Patched PF02460.18 KII69989.1 - 6.1e-18 64.3 18.9 7e-18 64.1 18.9 1.0 1 0 0 1 1 1 1 Patched family DUF4500 PF14937.6 KII69989.1 - 0.67 10.0 5.7 3.6 7.7 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4500) FUSC-like PF12805.7 KII69989.1 - 0.78 8.8 7.9 1.2 8.2 7.9 1.3 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS ACR_tran PF00873.19 KII69989.1 - 1.2 6.7 9.4 1.4 6.5 9.4 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Patched PF02460.18 KII69990.1 - 2e-46 158.5 6.0 2.6e-46 158.2 4.9 1.6 1 1 1 2 2 2 1 Patched family Sterol-sensing PF12349.8 KII69990.1 - 7.4e-40 136.3 13.3 7.4e-40 136.3 13.3 2.6 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation NPC1_N PF16414.5 KII69990.1 - 2.9e-35 122.0 8.5 5.7e-35 121.0 8.5 1.4 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus ADAM17_MPD PF16698.5 KII69990.1 - 0.035 14.5 0.4 0.035 14.5 0.4 2.8 3 0 0 3 3 3 0 Membrane-proximal domain, switch, for ADAM17 ATP-synt_ab_C PF00306.27 KII69990.1 - 0.093 13.1 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta chain, C terminal domain MMPL PF03176.15 KII69990.1 - 3.3 6.5 11.1 6.3 5.6 11.1 1.4 1 0 0 1 1 1 0 MMPL family Bac_export_3 PF01313.19 KII69991.1 - 0.74 9.8 5.3 5.5 7.0 1.4 2.3 2 0 0 2 2 2 0 Bacterial export proteins, family 3 LRR_4 PF12799.7 KII69993.1 - 1.4e-14 53.9 17.0 0.00011 22.5 0.2 4.7 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KII69993.1 - 1.9e-12 46.7 17.8 6.2e-06 25.9 4.1 4.0 2 2 2 4 4 4 4 Leucine rich repeat LRR_6 PF13516.6 KII69993.1 - 1.6e-09 37.0 11.7 0.12 12.5 1.2 6.5 6 0 0 6 6 6 3 Leucine Rich repeat LRR_1 PF00560.33 KII69993.1 - 1.3e-07 31.2 15.0 3 8.7 0.1 7.3 6 2 1 7 7 7 2 Leucine Rich Repeat CH PF00307.31 KII69993.1 - 0.012 15.7 0.1 0.028 14.6 0.1 1.6 1 0 0 1 1 1 0 Calponin homology (CH) domain LRR_9 PF14580.6 KII69993.1 - 0.04 13.4 6.3 0.2 11.2 6.0 2.1 1 1 0 1 1 1 0 Leucine-rich repeat CAMSAP_CH PF11971.8 KII69993.1 - 0.043 13.6 0.1 0.15 11.9 0.1 1.9 1 0 0 1 1 1 0 CAMSAP CH domain MT-A70 PF05063.14 KII69994.1 - 7.2e-49 166.0 0.1 1.3e-48 165.2 0.1 1.4 1 0 0 1 1 1 1 MT-A70 HTH_Tnp_Tc5 PF03221.16 KII69996.1 - 0.0023 17.9 0.1 0.0038 17.2 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HEPN_AbiV PF18728.1 KII69996.1 - 0.016 15.4 0.1 0.02 15.1 0.1 1.1 1 0 0 1 1 1 0 AbiV XAP5 PF04921.14 KII69997.1 - 9e-37 127.2 5.3 3.7e-36 125.2 5.3 1.7 1 1 0 1 1 1 1 XAP5, circadian clock regulator PIN_4 PF13638.6 KII69997.1 - 0.088 13.1 0.1 1.6 9.1 0.0 2.2 2 0 0 2 2 2 0 PIN domain HTH_Tnp_Tc3_2 PF01498.18 KII69998.1 - 8e-06 26.0 0.0 1.7e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Transposase DDE_3 PF13358.6 KII69998.1 - 7.7e-05 22.5 0.0 0.032 14.0 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_32 PF13565.6 KII69998.1 - 0.0077 16.8 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Glyco_hydro_5_C PF18564.1 KII69999.1 - 0.16 12.5 0.1 0.3 11.7 0.1 1.4 1 0 0 1 1 1 0 Glycoside hydrolase family 5 C-terminal domain SLATT_6 PF18169.1 KII70000.1 - 0.11 12.1 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 RRM_1 PF00076.22 KII70001.1 - 3e-40 135.9 0.1 7.2e-17 61.0 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KII70001.1 - 0.0029 17.4 0.0 0.11 12.4 0.0 3.1 3 1 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 KII70001.1 - 0.045 13.9 0.0 1.1 9.4 0.0 2.7 2 0 0 2 2 2 0 RNA recognition motif Nup35_RRM_2 PF14605.6 KII70001.1 - 0.12 12.4 0.0 1.9 8.5 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Transformer PF06495.11 KII70001.1 - 0.15 12.2 24.1 0.32 11.1 24.1 1.5 1 0 0 1 1 1 0 Fruit fly transformer protein DUF2839 PF10999.8 KII70001.1 - 0.21 12.0 0.8 0.53 10.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) SOBP PF15279.6 KII70001.1 - 7.5 7.1 8.3 3.4 8.2 5.8 1.6 2 0 0 2 2 2 0 Sine oculis-binding protein Tubulin PF00091.25 KII70002.1 - 5.1e-59 199.8 0.0 6e-59 199.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 KII70002.1 - 0.00037 20.2 0.0 0.00057 19.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 KII70002.1 - 0.011 15.0 0.0 0.033 13.4 0.0 1.8 2 0 0 2 2 2 0 Tubulin like Tubulin_C PF03953.17 KII70003.1 - 4.9e-16 59.1 0.3 4.9e-16 59.1 0.3 1.4 2 0 0 2 2 2 1 Tubulin C-terminal domain MCM PF00493.23 KII70004.1 - 1.6e-90 302.1 0.0 2.4e-90 301.5 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KII70004.1 - 3.4e-38 130.3 0.8 6.5e-38 129.4 0.8 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KII70004.1 - 5.7e-23 81.2 0.6 5.7e-23 81.2 0.6 2.5 3 0 0 3 3 3 1 MCM AAA-lid domain MCM_N PF14551.6 KII70004.1 - 7e-12 45.9 1.7 7e-12 45.9 1.7 3.2 4 0 0 4 4 4 1 MCM N-terminal domain Mg_chelatase PF01078.21 KII70004.1 - 8.1e-07 28.6 0.0 2.2e-05 24.0 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KII70004.1 - 1.6e-05 25.0 0.0 8.3e-05 22.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KII70004.1 - 9.7e-05 22.2 0.0 0.0017 18.2 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KII70004.1 - 0.021 14.6 0.0 2.2 8.0 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF2624 PF11116.8 KII70004.1 - 2.7 8.9 7.1 53 4.8 0.1 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF2624) AgI_II_C2 PF17998.1 KII70005.1 - 0.0039 17.5 1.0 0.0043 17.4 1.0 1.1 1 0 0 1 1 1 1 Cell surface antigen I/II C2 terminal domain Mltc_N PF11873.8 KII70005.1 - 0.05 13.3 0.1 0.058 13.1 0.1 1.1 1 0 0 1 1 1 0 Membrane-bound lytic murein transglycosylase C, N-terminal domain Ribosomal_S7e PF01251.18 KII70006.1 - 7.2e-39 133.4 0.9 8.9e-39 133.1 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S7e Raftlin PF15250.6 KII70006.1 - 0.043 12.6 0.2 0.056 12.2 0.2 1.1 1 0 0 1 1 1 0 Raftlin EF-G-binding_N PF07299.11 KII70006.1 - 0.15 12.6 0.5 0.42 11.2 0.2 1.9 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal DDE_3 PF13358.6 KII70007.1 - 3.1e-13 49.7 0.0 4.3e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease C2 PF00168.30 KII70008.1 - 2.8e-44 149.6 12.7 1.2e-15 57.7 0.6 6.5 6 0 0 6 6 6 6 C2 domain FYVE_2 PF02318.16 KII70008.1 - 1.8e-14 54.0 4.1 1.8e-14 54.0 4.1 2.4 2 0 0 2 2 2 1 FYVE-type zinc finger Inhibitor_Mig-6 PF11555.8 KII70009.1 - 0.19 11.8 0.0 0.32 11.1 0.0 1.3 1 0 0 1 1 1 0 EGFR receptor inhibitor Mig-6 MFS_1 PF07690.16 KII70010.1 - 5.4e-10 38.7 24.0 1.2e-06 27.7 13.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRAP_beta PF05753.14 KII70011.1 - 4.2e-23 81.7 0.3 4.6e-23 81.5 0.3 1.0 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DUF5436 PF17504.2 KII70011.1 - 0.05 13.9 0.1 0.12 12.7 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5436) OST3_OST6 PF04756.13 KII70013.1 - 1.3e-18 67.4 8.1 1.5e-18 67.2 8.1 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF3792 PF12670.7 KII70013.1 - 0.29 11.3 9.9 0.77 9.9 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) DUF2070 PF09843.9 KII70013.1 - 0.55 8.5 7.6 0.65 8.2 7.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Phage_holin_1 PF04531.13 KII70013.1 - 1 10.0 4.1 0.82 10.2 0.7 2.2 1 1 1 2 2 2 0 Bacteriophage holin TssN PF17555.2 KII70013.1 - 2 7.7 11.8 0.72 9.2 2.6 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssN Yip1 PF04893.17 KII70013.1 - 2.5 7.8 10.7 0.25 11.1 3.9 2.1 2 1 0 2 2 2 0 Yip1 domain OST3_OST6 PF04756.13 KII70014.1 - 9.3e-05 21.9 0.1 9.6e-05 21.9 0.1 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family MFS_1 PF07690.16 KII70015.1 - 5.4e-10 38.7 8.2 7.1e-10 38.3 8.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KII70015.1 - 0.00071 18.5 5.1 0.00071 18.5 5.1 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter DUF21 PF01595.20 KII70015.1 - 0.055 13.2 1.0 0.073 12.8 1.0 1.1 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain MFS_1 PF07690.16 KII70016.1 - 1.7e-10 40.4 12.4 3e-10 39.6 12.4 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily TMEM40 PF15817.5 KII70016.1 - 0.15 11.8 1.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 Transmembrane protein 40 family zf-C2H2_8 PF15909.5 KII70020.1 - 0.0096 16.2 0.2 0.019 15.3 0.2 1.5 1 0 0 1 1 1 1 C2H2-type zinc ribbon Integrase_H2C2 PF17921.1 KII70023.1 - 2.4e-19 69.2 0.5 4e-19 68.5 0.5 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII70023.1 - 0.00016 21.8 0.0 0.00028 21.1 0.0 1.3 1 0 0 1 1 1 1 H2C2 zinc finger rve PF00665.26 KII70023.1 - 0.00025 21.2 0.0 0.00034 20.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Cu2_monooxygen PF01082.20 KII70024.1 - 0.00027 21.2 0.0 0.00036 20.8 0.0 1.3 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain MLVIN_C PF18697.1 KII70024.1 - 0.0003 20.8 0.0 0.00045 20.3 0.0 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DUF4930 PF16284.5 KII70024.1 - 0.073 13.0 0.2 0.089 12.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4930) RT_RNaseH_2 PF17919.1 KII70025.1 - 4.8e-34 116.4 0.0 1.5e-33 114.8 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII70025.1 - 1.6e-33 115.1 0.1 4.9e-33 113.5 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70025.1 - 6.3e-32 110.9 0.1 1.4e-31 109.7 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII70025.1 - 2.9e-21 75.8 0.0 1.1e-20 74.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70025.1 - 1.5e-15 57.0 0.9 4e-15 55.7 0.1 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain Spuma_A9PTase PF03539.14 KII70025.1 - 4.3e-05 23.7 0.0 9.3e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) rve_3 PF13683.6 KII70025.1 - 0.0018 18.0 0.0 0.0052 16.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.11 KII70025.1 - 0.027 14.2 0.5 0.048 13.4 0.5 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF1944 PF09175.10 KII70025.1 - 0.079 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1944) zf-ZPR1 PF03367.13 KII70025.1 - 0.09 12.6 0.4 0.3 10.9 0.4 1.8 1 0 0 1 1 1 0 ZPR1 zinc-finger domain WWE PF02825.20 KII70026.1 - 0.0084 16.7 0.2 0.54 10.9 0.0 2.7 2 0 0 2 2 2 2 WWE domain gag-asp_proteas PF13975.6 KII70028.1 - 9.7e-09 35.7 0.0 2.5e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII70028.1 - 5.5e-07 30.2 0.0 1.1e-06 29.2 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 KII70028.1 - 0.027 14.2 0.6 0.081 12.7 0.6 1.8 1 1 0 1 1 1 0 Retroviral aspartyl protease Asp_protease PF09668.10 KII70028.1 - 0.038 13.8 0.1 0.079 12.8 0.1 1.6 1 1 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII70028.1 - 0.071 13.4 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC PF00098.23 KII70028.1 - 1.6 9.0 9.5 0.13 12.4 3.5 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 KII70028.1 - 5.3 6.8 8.0 15 5.4 0.5 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 KII70028.1 - 9.4 6.3 7.8 1.8 8.6 0.5 2.3 1 1 1 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 KII70031.1 - 3.1e-33 113.8 0.0 8.3e-33 112.4 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII70031.1 - 1.3e-31 109.0 0.0 3.1e-31 107.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII70031.1 - 2.2e-18 66.6 0.0 7.5e-18 64.9 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70031.1 - 1.6e-16 60.1 0.4 3.9e-16 58.9 0.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII70031.1 - 2.6e-06 27.5 0.0 1e-05 25.6 0.0 2.2 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII70031.1 - 0.00034 20.3 0.1 0.0013 18.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain RVT_1 PF00078.27 KII70031.1 - 0.0075 15.8 0.2 0.017 14.6 0.2 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-met PF12874.7 KII70034.1 - 1.6e-05 25.1 1.2 2.6e-05 24.5 1.2 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 KII70034.1 - 0.00016 21.4 0.7 0.00029 20.5 0.7 1.4 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.8 KII70034.1 - 0.00024 21.3 0.6 0.00051 20.3 0.6 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF826 PF05696.11 KII70034.1 - 0.055 13.5 0.4 0.17 12.0 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF826) PIEZO PF15917.5 KII70034.1 - 1.4 8.3 14.1 0.18 11.2 10.1 1.5 2 0 0 2 2 2 0 Piezo Atg14 PF10186.9 KII70034.1 - 1.7 7.6 9.8 2.7 7.0 9.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DDE_3 PF13358.6 KII70035.1 - 2.4e-10 40.3 0.1 2.7e-10 40.2 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease PcfK PF14058.6 KII70035.1 - 0.091 13.0 0.0 0.095 13.0 0.0 1.2 1 0 0 1 1 1 0 PcfK-like protein Rx_N PF18052.1 KII70035.1 - 0.11 12.8 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Rx N-terminal domain Agenet PF05641.12 KII70036.1 - 0.049 14.1 0.1 0.37 11.3 0.0 2.3 2 0 0 2 2 2 0 Agenet domain Myosin_N PF02736.19 KII70036.1 - 0.084 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Kelch_5 PF13854.6 KII70037.1 - 6.3e-08 32.4 3.1 0.0009 19.2 0.2 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 KII70037.1 - 1.5e-05 25.1 5.0 0.006 16.8 0.5 2.6 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII70037.1 - 0.00013 21.9 5.1 0.011 15.8 0.2 2.5 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII70037.1 - 0.0011 18.6 10.5 0.081 12.5 0.9 2.9 2 1 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII70037.1 - 0.0014 18.6 5.8 0.51 10.4 0.2 2.6 2 1 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII70037.1 - 0.022 15.1 4.6 1.6 9.1 0.0 3.4 3 1 0 3 3 3 0 Galactose oxidase, central domain Claudin_3 PF06653.11 KII70038.1 - 0.00039 20.4 7.8 0.0007 19.6 7.8 1.3 1 0 0 1 1 1 1 Tight junction protein, Claudin-like Oxidored_q3 PF00499.20 KII70038.1 - 0.001 18.8 1.1 0.012 15.4 0.7 2.0 2 0 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Orai-1 PF07856.12 KII70038.1 - 0.0037 17.0 0.7 0.0055 16.4 0.7 1.2 1 0 0 1 1 1 1 Mediator of CRAC channel activity L_HMGIC_fpl PF10242.9 KII70038.1 - 0.022 15.0 5.1 0.05 13.8 5.1 1.5 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein DUF3792 PF12670.7 KII70038.1 - 0.46 10.7 15.5 0.62 10.2 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3792) Clc-like PF07062.12 KII70038.1 - 0.77 9.2 6.1 11 5.4 5.5 2.2 1 1 0 1 1 1 0 Clc-like HlyIII PF03006.20 KII70038.1 - 2.4 7.8 11.8 7.8 6.1 11.3 1.7 1 1 1 2 2 2 0 Haemolysin-III related ABC2_membrane_3 PF12698.7 KII70038.1 - 3.6 6.6 11.3 1.2 8.1 7.1 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein HTH_Tnp_Tc3_2 PF01498.18 KII70039.1 - 0.00014 22.0 0.6 0.00048 20.3 0.2 1.9 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.6 KII70039.1 - 0.00014 21.4 0.0 0.00055 19.5 0.0 2.0 2 1 0 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.6 KII70039.1 - 0.0016 19.0 0.0 0.0031 18.1 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.16 KII70039.1 - 0.0022 18.0 1.2 0.0031 17.6 1.2 1.2 1 0 0 1 1 1 1 Transposase PAX PF00292.18 KII70039.1 - 0.012 15.5 0.1 0.018 15.0 0.1 1.2 1 0 0 1 1 1 0 'Paired box' domain Arg_repressor PF01316.21 KII70039.1 - 0.02 14.6 0.6 0.036 13.8 0.6 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DDE_3 PF13358.6 KII70039.1 - 0.034 13.9 0.0 0.093 12.5 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_40 PF14493.6 KII70039.1 - 0.4 11.2 3.8 0.79 10.2 1.0 2.2 1 1 1 2 2 2 0 Helix-turn-helix domain TAN PF11640.8 KII70041.1 - 0.0033 17.6 0.7 0.0048 17.1 0.7 1.3 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair zf-CCHC PF00098.23 KII70042.1 - 5.1e-05 23.2 4.4 9.5e-05 22.3 4.4 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 KII70042.1 - 0.0087 15.8 0.7 0.016 14.9 0.7 1.4 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Vasohibin PF14822.6 KII70042.1 - 0.045 13.0 0.0 0.079 12.2 0.0 1.4 1 0 0 1 1 1 0 Vasohibin IL7 PF01415.16 KII70043.1 - 0.012 15.7 0.8 2.9 7.9 0.0 3.3 2 1 1 3 3 3 0 Interleukin 7/9 family rve PF00665.26 KII70044.1 - 4e-25 88.3 0.0 6.8e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70044.1 - 0.0011 19.0 1.4 0.0027 17.8 1.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_Tnp_IS240 PF13610.6 KII70044.1 - 0.0028 17.9 0.1 0.0065 16.7 0.0 1.6 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.6 KII70044.1 - 0.0041 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII70044.1 - 0.078 13.1 0.0 0.26 11.4 0.0 1.9 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DcpS_C PF11969.8 KII70045.1 - 8.8e-24 84.2 0.1 1.7e-23 83.2 0.1 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 KII70045.1 - 0.0002 22.2 0.0 0.00059 20.6 0.0 1.8 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal HIT PF01230.23 KII70045.1 - 0.023 15.4 0.1 0.063 14.0 0.1 1.7 1 0 0 1 1 1 0 HIT domain DUF3432 PF11914.8 KII70046.1 - 0.11 12.7 4.3 0.14 12.4 3.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) BES1_N PF05687.13 KII70046.1 - 2.6 8.4 4.4 2.3 8.6 3.4 1.6 1 1 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal ShK PF01549.24 KII70047.1 - 3.7e-06 27.4 11.0 3.7e-06 27.4 11.0 2.8 3 1 0 3 3 3 1 ShK domain-like ShK PF01549.24 KII70049.1 - 4.2e-06 27.2 8.9 6.1e-06 26.7 8.9 1.3 1 0 0 1 1 1 1 ShK domain-like BPS1 PF05633.11 KII70049.1 - 0.0068 15.5 0.3 0.016 14.2 0.0 1.6 2 0 0 2 2 2 1 Protein BYPASS1-related PLAC PF08686.11 KII70049.1 - 0.078 13.7 8.4 0.15 12.9 8.4 1.5 1 0 0 1 1 1 0 PLAC (protease and lacunin) domain zf-nanos PF05741.13 KII70050.1 - 1.2e-22 79.9 3.7 2e-22 79.1 3.7 1.4 1 0 0 1 1 1 1 Nanos RNA binding domain zf-HIT PF04438.16 KII70050.1 - 0.78 9.7 6.1 4.5 7.2 1.4 2.5 2 0 0 2 2 2 0 HIT zinc finger Aldo_ket_red PF00248.21 KII70053.1 - 2e-28 99.5 0.0 2.6e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family HSCB_C PF07743.13 KII70053.1 - 0.0008 19.9 0.1 0.0015 19.0 0.1 1.4 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DUF3314 PF11771.8 KII70053.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3314) DUF5634 PF18681.1 KII70053.1 - 0.13 12.6 0.9 1.7 9.0 0.1 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5634) Aldo_ket_red PF00248.21 KII70054.1 - 8e-51 173.0 0.1 1.3e-50 172.3 0.1 1.2 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII70055.1 - 6e-25 88.0 0.0 9e-25 87.5 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family UPF0370 PF13980.6 KII70055.1 - 0.011 15.8 0.1 0.026 14.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) Aldo_ket_red PF00248.21 KII70058.1 - 1.3e-08 34.4 0.1 1.5e-08 34.2 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII70059.1 - 1.9e-31 109.4 0.0 2.3e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII70060.1 - 8.3e-10 38.3 0.1 1e-09 38.1 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII70061.1 - 1.3e-27 96.7 0.1 3.1e-27 95.5 0.1 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII70063.1 - 1.8e-23 83.2 0.1 4e-23 82.1 0.1 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII70066.1 - 1e-43 149.6 0.0 1.4e-43 149.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family ThiC-associated PF13667.6 KII70067.1 - 0.13 12.1 0.1 10 6.0 0.0 2.4 1 1 1 2 2 2 0 ThiC-associated domain Ripply PF14998.6 KII70067.1 - 0.26 11.9 1.0 17 6.2 0.2 2.5 1 1 1 2 2 2 0 Transcription Regulator OST3_OST6 PF04756.13 KII70070.1 - 2.5e-29 102.5 4.7 2.9e-29 102.3 4.7 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF1129 PF06570.11 KII70070.1 - 0.24 10.9 4.7 0.47 9.9 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Fer4_6 PF12837.7 KII70071.1 - 0.071 13.2 1.2 0.071 13.2 1.2 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain E1_DerP2_DerF2 PF02221.15 KII70072.1 - 1.9e-17 64.0 0.5 2.2e-17 63.7 0.5 1.1 1 0 0 1 1 1 1 ML domain KH_1 PF00013.29 KII70074.1 - 1.4e-37 127.3 13.4 3.6e-07 29.9 0.0 11.1 12 0 0 12 12 12 7 KH domain MOEP19 PF16005.5 KII70074.1 - 0.03 14.3 0.0 0.45 10.5 0.0 2.9 3 0 0 3 3 3 0 KH-like RNA-binding domain ribosomal_L24 PF17136.4 KII70074.1 - 0.046 14.1 0.1 0.14 12.6 0.1 1.9 1 0 0 1 1 1 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 DUF503 PF04456.12 KII70074.1 - 0.13 12.1 0.7 0.63 9.9 0.7 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF503) SNAP PF14938.6 KII70075.1 - 0.01 15.3 0.7 0.015 14.8 0.7 1.2 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP SNAP PF14938.6 KII70077.1 - 0.0061 16.0 0.5 0.0076 15.7 0.5 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NSF PF02071.20 KII70077.1 - 8.5 7.7 9.8 6.3 8.0 0.1 3.9 4 1 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TMEM52 PF14979.6 KII70078.1 - 0.00016 21.6 0.2 0.00032 20.7 0.2 1.5 1 0 0 1 1 1 1 Transmembrane 52 Renin_r PF07850.14 KII70079.1 - 0.014 15.9 0.2 0.058 14.0 0.2 2.1 1 0 0 1 1 1 0 Renin receptor-like protein Glyco_transf_54 PF04666.13 KII70080.1 - 1.5e-33 115.9 0.4 1.8e-33 115.7 0.4 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Cys_Met_Meta_PP PF01053.20 KII70081.1 - 3.5e-24 85.1 0.0 3.8e-24 85.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 KII70081.1 - 0.0053 16.1 0.0 0.0059 16.0 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 KII70081.1 - 0.035 13.4 0.0 0.039 13.2 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase Ribosomal_L18A PF01775.17 KII70082.1 - 1e-45 154.7 2.9 1.6e-45 154.1 2.9 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF4160 PF13711.6 KII70082.1 - 0.02 15.2 0.1 0.062 13.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) DUF3149 PF11346.8 KII70082.1 - 0.48 10.1 1.5 0.85 9.3 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) RT_RNaseH PF17917.1 KII70083.1 - 8.6e-17 61.3 0.0 2.5e-14 53.4 0.0 2.3 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII70083.1 - 3.8e-15 55.7 0.0 6.2e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70083.1 - 0.012 15.2 0.7 0.83 9.1 0.7 2.3 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII70084.1 - 6.5e-17 61.4 0.6 9.6e-17 60.8 0.6 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII70084.1 - 0.0025 18.0 0.0 0.0043 17.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain GTP_EFTU_D4 PF14578.6 KII70085.1 - 3.6e-05 23.6 0.2 5.4e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 KII70086.1 - 2e-15 56.8 0.1 3e-14 53.1 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KII70086.1 - 6.1e-08 32.7 0.2 1.9e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 KII70086.1 - 8.2e-07 28.7 0.0 3.6e-05 23.3 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KII70086.1 - 0.097 12.7 2.0 0.66 10.0 0.2 2.8 2 1 1 3 3 3 0 Dynamin family RT_RNaseH_2 PF17919.1 KII70087.1 - 8e-12 45.1 0.0 9.7e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII70087.1 - 0.071 13.4 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Clat_adaptor_s PF01217.20 KII70090.1 - 1.1e-23 83.7 5.9 2.9e-23 82.4 5.9 1.6 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Clat_adaptor_s PF01217.20 KII70091.1 - 2.6e-25 89.0 3.2 2.9e-25 88.8 3.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MRG PF05712.13 KII70091.1 - 0.094 12.0 1.0 0.16 11.2 0.1 1.8 1 1 1 2 2 2 0 MRG rve PF00665.26 KII70093.1 - 0.005 17.0 0.1 0.0059 16.8 0.1 1.1 1 0 0 1 1 1 1 Integrase core domain CRC_subunit PF08624.10 KII70097.1 - 0.016 15.6 0.1 0.038 14.4 0.1 1.5 1 1 0 1 1 1 0 Chromatin remodelling complex Rsc7/Swp82 subunit MULE PF10551.9 KII70099.1 - 0.0014 19.0 0.1 0.003 17.9 0.1 1.6 1 0 0 1 1 1 1 MULE transposase domain Myb_DNA-bind_5 PF13873.6 KII70100.1 - 5.9e-13 48.7 5.0 1.1e-12 47.8 5.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain TAN PF11640.8 KII70100.1 - 0.041 14.0 0.6 0.21 11.7 0.8 1.8 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair DUF2516 PF10724.9 KII70103.1 - 0.033 14.5 0.3 0.05 13.9 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2516) Y1_Tnp PF01797.16 KII70105.1 - 0.01 15.9 0.2 0.016 15.3 0.2 1.3 1 0 0 1 1 1 0 Transposase IS200 like F-box-like_2 PF13013.6 KII70108.1 - 0.63 10.0 4.2 0.22 11.5 1.6 1.5 2 0 0 2 2 2 0 F-box-like domain PDR_CDR PF06422.12 KII70109.1 - 0.051 13.5 0.0 0.06 13.3 0.0 1.2 1 0 0 1 1 1 0 CDR ABC transporter DDE_3 PF13358.6 KII70113.1 - 1e-19 70.7 0.0 1.4e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII70113.1 - 0.00012 22.3 0.0 0.0005 20.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Diphthamide_syn PF01866.17 KII70113.1 - 0.036 13.5 0.0 0.04 13.4 0.0 1.1 1 0 0 1 1 1 0 Putative diphthamide synthesis protein CotJA PF11007.8 KII70115.1 - 0.087 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Spore coat associated protein JA (CotJA) Glyco_trans_2_3 PF13632.6 KII70116.1 - 0.056 13.3 0.0 0.067 13.1 0.0 1.3 1 1 0 1 1 1 0 Glycosyl transferase family group 2 DUF4939 PF16297.5 KII70116.1 - 0.084 12.8 0.2 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4939) DDE_3 PF13358.6 KII70118.1 - 0.00089 19.0 0.7 0.0044 16.8 0.3 1.9 1 1 1 2 2 2 1 DDE superfamily endonuclease zf_ZIC PF18366.1 KII70119.1 - 0.084 13.0 0.6 0.15 12.2 0.6 1.4 1 0 0 1 1 1 0 Zic proteins zinc finger domain BAG PF02179.16 KII70121.1 - 0.086 13.3 0.1 0.14 12.6 0.1 1.3 1 0 0 1 1 1 0 BAG domain Kelch_6 PF13964.6 KII70122.1 - 9.4e-17 60.6 8.2 0.00014 22.0 0.1 3.7 3 1 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII70122.1 - 2e-16 59.3 8.3 6.2e-06 25.7 0.9 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII70122.1 - 2e-13 50.1 1.3 0.0021 18.0 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII70122.1 - 4e-11 42.9 2.6 0.015 15.6 0.4 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII70122.1 - 5.6e-11 42.2 3.0 5.9e-05 22.9 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KII70122.1 - 1.6e-06 27.8 3.8 0.35 10.9 0.0 3.4 3 0 0 3 3 3 3 Kelch motif zf-CCHC_5 PF14787.6 KII70123.1 - 2.2e-05 24.0 0.6 3.7e-05 23.3 0.6 1.3 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.23 KII70123.1 - 0.0004 20.3 1.0 0.00061 19.7 1.0 1.3 1 0 0 1 1 1 1 Zinc knuckle zf_CCCH_4 PF18345.1 KII70126.1 - 2.7e-11 43.1 17.4 2.4e-06 27.4 3.6 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 KII70126.1 - 8.2e-10 38.3 11.4 1.2e-05 25.0 1.7 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 KII70126.1 - 2.4e-08 33.7 8.9 4.3e-05 23.3 1.4 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 KII70126.1 - 5.5e-08 33.0 2.2 7.7e-08 32.5 2.2 1.3 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 KII70126.1 - 2.8e-07 30.7 13.1 0.0012 19.2 2.4 2.7 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KII70126.1 - 6.8e-06 26.7 12.1 0.00045 20.9 1.8 2.9 2 2 1 3 3 3 2 Torus domain DUF1398 PF07166.11 KII70126.1 - 0.0037 17.3 0.0 0.0073 16.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1398) zf_C2H2_13 PF18508.1 KII70126.1 - 0.061 12.9 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Zinc finger domain Ank_2 PF12796.7 KII70127.1 - 2.1e-21 76.3 0.0 4.3e-12 46.4 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KII70127.1 - 3.4e-12 46.3 0.0 7.5e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII70127.1 - 1.1e-10 40.8 0.0 0.0013 19.0 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KII70127.1 - 1.8e-10 41.1 0.0 1.2e-05 25.7 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KII70127.1 - 7.5e-10 38.8 0.0 0.0019 18.6 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat SH3_9 PF14604.6 KII70127.1 - 1.1e-05 25.2 0.0 2.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KII70127.1 - 0.0013 18.4 0.0 0.0079 15.9 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain DUF3447 PF11929.8 KII70127.1 - 0.043 13.8 0.2 4.1 7.4 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3447) SH3_1 PF00018.28 KII70127.1 - 0.049 13.3 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 SH3 domain BSD PF03909.17 KII70128.1 - 3.1e-08 33.5 0.1 6.2e-08 32.5 0.1 1.5 1 0 0 1 1 1 1 BSD domain GH43_C2 PF17851.1 KII70128.1 - 0.088 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Beta xylosidase C-terminal Concanavalin A-like domain Got1 PF04178.12 KII70130.1 - 1.6e-10 41.4 18.2 2.1e-10 41.0 18.2 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF308 PF03729.13 KII70130.1 - 8.6 6.8 23.7 1 9.7 8.7 2.6 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) zf-DNL PF05180.12 KII70131.1 - 3.4e-27 94.2 2.2 4.9e-27 93.6 2.2 1.2 1 0 0 1 1 1 1 DNL zinc finger DUF5011 PF16403.5 KII70131.1 - 0.16 12.1 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5011) Cation_ATPase_C PF00689.21 KII70132.1 - 6.4e-38 130.3 2.6 8.7e-38 129.8 2.6 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KII70132.1 - 1.1e-13 51.9 0.0 4.1e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KII70132.1 - 4.7e-05 23.2 0.4 0.014 15.2 0.2 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 KII70132.1 - 0.058 13.8 0.0 0.53 10.6 0.0 2.1 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KII70133.1 - 7.1e-45 152.8 8.5 2.4e-44 151.0 2.6 2.3 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase PF13246.6 KII70133.1 - 1.1e-16 60.7 0.1 3.6e-16 59.0 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KII70133.1 - 2e-05 24.2 0.0 4.3e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DUF4149 PF13664.6 KII70133.1 - 0.01 16.1 0.1 0.01 16.1 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) DUF1772 PF08592.11 KII70133.1 - 0.012 16.0 0.1 0.034 14.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF3611 PF12263.8 KII70133.1 - 1.4 8.8 7.4 0.81 9.6 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) DUF3784 PF12650.7 KII70133.1 - 3.5 7.9 11.8 0.78 10.0 1.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) FAM60A PF15396.6 KII70135.1 - 1.1e-07 32.1 3.0 4.2e-07 30.2 0.0 2.0 2 0 0 2 2 2 2 Protein Family FAM60A Rep_fac-A_C PF08646.10 KII70136.1 - 7.1e-39 132.9 0.3 1e-36 125.9 0.1 2.5 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KII70136.1 - 6e-25 87.0 0.1 3e-23 81.6 0.0 2.9 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 KII70136.1 - 2.5e-06 27.4 0.0 0.0014 18.6 0.0 2.6 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain IBR PF01485.21 KII70136.1 - 0.00041 20.5 1.5 0.00086 19.5 1.5 1.4 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zinc-ribbons_6 PF07191.12 KII70136.1 - 0.041 13.9 1.5 0.076 13.0 1.5 1.3 1 0 0 1 1 1 0 zinc-ribbons Evr1_Alr PF04777.13 KII70136.1 - 0.13 12.8 1.0 0.27 11.7 1.0 1.5 1 0 0 1 1 1 0 Erv1 / Alr family Hydrolase PF00702.26 KII70137.1 - 1.8e-06 28.4 0.0 2.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KII70137.1 - 0.015 15.4 0.1 0.81 9.8 0.0 2.5 2 0 0 2 2 2 0 Cation transport ATPase (P-type) EntA_Immun PF08951.10 KII70137.1 - 0.025 15.0 0.6 2.5 8.5 0.1 2.4 2 0 0 2 2 2 0 Enterocin A Immunity DUF2608 PF11019.8 KII70137.1 - 0.058 12.9 0.1 0.34 10.3 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2608) NYN_YacP PF05991.11 KII70137.1 - 0.081 12.9 0.1 0.13 12.2 0.1 1.5 1 1 0 1 1 1 0 YacP-like NYN domain GreA_GreB_N PF03449.15 KII70137.1 - 0.082 13.1 0.7 0.16 12.1 0.1 1.8 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal HSP20 PF00011.21 KII70138.1 - 8.5e-27 93.3 1.9 2.2e-15 56.7 0.8 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII70138.1 - 4.8e-05 22.8 0.1 0.23 11.1 0.1 2.5 2 1 0 2 2 2 2 HSP20-like domain found in ArsA DDE_Tnp_IS1595 PF12762.7 KII70139.1 - 1.3e-05 25.2 0.0 2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DNA_primase_lrg PF04104.14 KII70141.1 - 1.3e-09 37.9 0.1 2.3e-09 37.0 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Ribosomal_L10 PF00466.20 KII70143.1 - 2.3e-18 66.2 1.9 3.8e-18 65.5 1.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 KII70143.1 - 2.7e-16 59.3 0.1 9.3e-16 57.6 0.1 2.0 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P DUF4107 PF13389.6 KII70143.1 - 0.12 12.5 0.4 0.31 11.2 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4107) polyprenyl_synt PF00348.17 KII70144.1 - 2.8e-60 203.6 0.3 1.2e-59 201.4 0.3 1.8 1 1 0 1 1 1 1 Polyprenyl synthetase DUF1896 PF08989.10 KII70144.1 - 0.094 12.8 0.8 0.24 11.5 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1896) Pmp3 PF01679.17 KII70144.1 - 0.16 12.2 1.1 6.5 7.0 0.2 2.4 2 0 0 2 2 2 0 Proteolipid membrane potential modulator RIBIOP_C PF04950.12 KII70146.1 - 1.6e-76 257.6 2.1 2.1e-76 257.2 1.6 1.5 1 1 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KII70146.1 - 2.7e-23 81.9 0.0 2.7e-23 81.9 0.0 2.6 3 1 0 3 3 3 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 KII70146.1 - 0.0007 19.2 0.0 0.0018 17.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain CDC45 PF02724.14 KII70146.1 - 2.9 6.1 11.7 5.4 5.2 11.7 1.3 1 0 0 1 1 1 0 CDC45-like protein PDZ PF00595.24 KII70147.1 - 3.4e-09 36.9 0.0 8.6e-05 22.8 0.0 2.9 2 1 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KII70147.1 - 9e-09 35.0 0.0 2.3e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KII70147.1 - 1.2e-05 25.5 0.0 3.6e-05 24.0 0.0 1.8 2 1 0 2 2 2 1 PDZ domain DUF2358 PF10184.9 KII70148.1 - 0.1 12.9 0.1 0.71 10.2 0.0 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2358) SPC25 PF06703.11 KII70149.1 - 0.073 12.9 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Sortilin_C PF15901.5 KII70151.1 - 1.3e-07 32.1 0.6 1.4e-07 32.0 0.6 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal MerR_1 PF13411.6 KII70152.1 - 0.057 13.5 0.2 0.072 13.2 0.2 1.2 1 0 0 1 1 1 0 MerR HTH family regulatory protein HTH_Tnp_IS630 PF01710.16 KII70152.1 - 0.11 12.5 0.1 0.13 12.3 0.1 1.1 1 0 0 1 1 1 0 Transposase RRM_1 PF00076.22 KII70153.1 - 1.3e-20 72.9 0.0 2.1e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 KII70153.1 - 8.7e-14 51.9 4.6 8.7e-14 51.9 4.6 3.0 2 2 1 3 3 3 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_5 PF13893.6 KII70153.1 - 0.063 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PEPCK_GTP PF00821.18 KII70155.1 - 1.3e-102 343.3 0.0 1.5e-102 343.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain Ribosomal_L31 PF01197.18 KII70158.1 - 0.091 13.0 0.2 0.48 10.7 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L31 SET PF00856.28 KII70159.1 - 5.2e-14 53.0 0.9 3.2e-13 50.4 0.0 2.4 2 1 0 2 2 2 1 SET domain Proteasome PF00227.26 KII70160.1 - 8.3e-39 133.0 0.0 1.1e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KII70160.1 - 1.1e-11 44.2 0.0 1.9e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature VapB_antitoxin PF09957.9 KII70160.1 - 0.019 14.9 0.1 0.042 13.8 0.1 1.6 1 0 0 1 1 1 0 Bacterial antitoxin of type II TA system, VapB DDE_3 PF13358.6 KII70161.1 - 1.5e-20 73.4 0.7 1.9e-20 73.1 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII70161.1 - 9.3e-07 28.4 0.0 2.1e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII70161.1 - 0.021 15.0 0.2 0.18 12.1 0.0 2.2 2 0 0 2 2 2 0 Transposase Imm-NTF2-2 PF15631.6 KII70161.1 - 0.15 12.3 0.1 0.88 9.9 0.0 2.0 2 0 0 2 2 2 0 NTF2 fold immunity protein Ldl_recept_a PF00057.18 KII70166.1 - 1.6e-08 34.6 48.8 0.0013 18.9 11.1 3.5 3 1 0 3 3 3 3 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII70167.1 - 3.6e-23 81.5 56.1 2.2e-11 43.8 9.0 4.4 3 2 1 4 4 4 3 Low-density lipoprotein receptor domain class A Reprolysin_2 PF13574.6 KII70168.1 - 6.6e-16 58.8 0.5 8.4e-16 58.4 0.5 1.0 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KII70168.1 - 4.1e-11 43.4 0.6 4.7e-11 43.2 0.6 1.0 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KII70168.1 - 1.9e-09 38.1 0.1 2.9e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KII70168.1 - 7.5e-07 29.0 0.2 8.3e-07 28.8 0.2 1.1 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 KII70168.1 - 7.2e-06 26.0 0.1 9.3e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M10 PF00413.24 KII70168.1 - 0.026 14.4 0.2 0.043 13.7 0.1 1.5 1 1 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.9 KII70168.1 - 0.052 12.5 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M85 PF13678.6 KII70168.1 - 0.099 12.2 0.2 0.13 11.9 0.2 1.1 1 0 0 1 1 1 0 NFkB-p65-degrading zinc protease DUF4953 PF16313.5 KII70168.1 - 0.13 11.4 0.1 0.17 11.1 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M43 PF05572.13 KII70168.1 - 0.14 12.1 0.1 0.19 11.7 0.1 1.2 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Reprolysin_2 PF13574.6 KII70169.1 - 1e-12 48.4 0.2 1.6e-12 47.8 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KII70169.1 - 4.4e-09 36.8 0.8 7.8e-09 36.0 0.6 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KII70169.1 - 1.9e-06 28.4 0.4 3.5e-06 27.5 0.4 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KII70169.1 - 4.8e-06 26.4 0.1 8.8e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 KII70169.1 - 0.00017 21.6 0.0 0.00031 20.7 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pox_F12L PF03337.13 KII70169.1 - 0.0037 15.5 0.1 0.0053 15.0 0.1 1.2 1 0 0 1 1 1 1 Poxvirus F12L protein Peptidase_M10 PF00413.24 KII70169.1 - 0.044 13.6 0.9 0.074 12.9 0.7 1.5 1 1 0 1 1 1 0 Matrixin ADAM17_MPD PF16698.5 KII70170.1 - 3.4e-06 27.3 17.4 3.4e-06 27.3 17.4 2.1 1 1 1 2 2 2 1 Membrane-proximal domain, switch, for ADAM17 DUF4181 PF13789.6 KII70170.1 - 0.041 14.1 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) GPR15L PF15854.5 KII70170.1 - 8.8 6.6 12.8 1.8 8.9 6.8 2.2 2 0 0 2 2 2 0 G-protein coupled receptor ligand 15 Usp PF00582.26 KII70171.1 - 3.5e-18 66.5 0.0 4.5e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Usp PF00582.26 KII70172.1 - 4.5e-13 49.9 0.0 5.5e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family DUF4371 PF14291.6 KII70173.1 - 0.0044 16.7 0.3 0.012 15.2 0.2 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) UPF0254 PF06787.11 KII70173.1 - 0.059 13.1 0.2 0.085 12.6 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) UNC-93 PF05978.16 KII70174.1 - 0.015 15.1 0.4 0.021 14.5 0.4 1.2 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 Rab5ip PF07019.12 KII70175.1 - 4.1e-10 40.1 1.3 4.6e-10 39.9 1.3 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) HTH_Tnp_Tc5 PF03221.16 KII70176.1 - 7.2e-08 32.4 1.0 1.2e-07 31.6 1.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_3 PF01381.22 KII70176.1 - 0.001 19.1 0.4 0.0019 18.2 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_IclR PF09339.10 KII70176.1 - 0.014 15.1 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_psq PF05225.16 KII70176.1 - 0.039 13.7 0.0 0.089 12.6 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_23 PF13384.6 KII70176.1 - 0.042 13.6 0.9 0.098 12.5 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain CENP-B_N PF04218.13 KII70176.1 - 0.078 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.6 KII70176.1 - 0.085 12.6 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Usp PF00582.26 KII70177.1 - 0.0001 22.8 0.0 0.00017 22.1 0.0 1.4 1 0 0 1 1 1 1 Universal stress protein family MFS_1_like PF12832.7 KII70179.1 - 3.7e-20 72.1 7.3 5.5e-20 71.6 7.3 1.3 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 KII70179.1 - 2.8e-09 36.4 0.1 3e-09 36.3 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.13 KII70179.1 - 0.0005 18.6 3.5 0.2 10.0 0.2 2.0 1 1 1 2 2 2 2 Transmembrane secretion effector Nuc_H_symport PF03825.16 KII70179.1 - 0.0081 15.2 7.1 0.0097 14.9 7.1 1.1 1 0 0 1 1 1 1 Nucleoside H+ symporter MARVEL PF01284.23 KII70179.1 - 0.036 14.1 4.3 0.069 13.2 1.7 2.0 2 0 0 2 2 2 0 Membrane-associating domain MRG PF05712.13 KII70180.1 - 4.3e-17 62.1 7.4 2.4e-15 56.4 7.4 2.0 1 1 0 1 1 1 1 MRG SRI PF08236.11 KII70180.1 - 0.11 12.7 0.8 31 4.8 0.1 2.8 2 1 1 3 3 3 0 SRI (Set2 Rpb1 interacting) domain DUF1461 PF07314.11 KII70180.1 - 2 8.3 5.0 1 9.3 0.9 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1461) EF-hand_7 PF13499.6 KII70182.1 - 2.4e-14 53.6 4.4 1.6e-06 28.5 0.5 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KII70182.1 - 2.4e-13 48.6 10.5 6.9e-06 25.2 1.7 5.0 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 KII70182.1 - 3.7e-12 45.1 8.0 2.2e-05 24.0 1.1 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 KII70182.1 - 1.1e-08 34.8 8.7 5e-05 23.1 0.0 4.4 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KII70182.1 - 8.6e-07 28.2 2.0 3.5e-05 23.1 0.6 3.3 3 0 0 3 3 3 1 EF hand Syntaxin PF00804.25 KII70182.1 - 0.053 13.2 0.1 0.082 12.6 0.1 1.3 1 0 0 1 1 1 0 Syntaxin DUF2666 PF10869.8 KII70182.1 - 0.059 13.6 0.5 1.1 9.5 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) MMADHC PF10229.9 KII70183.1 - 8.6e-11 42.1 0.1 1.2e-10 41.6 0.1 1.2 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein DUF2543 PF10820.8 KII70183.1 - 0.13 12.4 0.1 20 5.5 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2543) ELFV_dehydrog_N PF02812.18 KII70184.1 - 5.4e-52 175.1 0.0 1.1e-51 174.1 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 KII70184.1 - 2.6e-47 161.6 0.1 3.3e-46 158.0 0.1 2.0 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Peptidase_C1 PF00112.23 KII70186.1 - 8.8e-29 101.2 0.0 1.6e-28 100.3 0.0 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII70186.1 - 6.7e-08 32.9 5.2 1e-07 32.2 5.2 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Ribosomal_L30_N PF08079.12 KII70186.1 - 0.81 10.0 3.0 1.5 9.2 1.2 2.0 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain Nucleoporin_N PF08801.11 KII70188.1 - 6.2e-14 51.6 5.5 4.3e-13 48.8 5.9 2.0 1 1 1 2 2 2 1 Nup133 N terminal like Drf_GBD PF06371.13 KII70188.1 - 0.017 14.7 0.7 0.032 13.8 0.7 1.4 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain iPGM_N PF06415.13 KII70191.1 - 4.1e-69 232.3 0.0 5.4e-69 231.9 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 KII70191.1 - 3.4e-68 229.7 0.0 3.9e-68 229.5 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 KII70191.1 - 0.00031 20.4 0.0 0.0056 16.3 0.0 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KII70191.1 - 0.1 12.0 0.0 0.8 9.0 0.0 2.2 2 0 0 2 2 2 0 Sulfatase LANC_like PF05147.13 KII70193.1 - 2.2e-61 207.4 0.2 2.6e-61 207.1 0.2 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_88 PF07470.13 KII70193.1 - 0.055 12.5 1.0 0.19 10.7 1.1 1.7 1 1 0 1 1 1 0 Glycosyl Hydrolase Family 88 MtrB PF05440.12 KII70193.1 - 0.076 13.4 0.0 0.32 11.4 0.0 1.9 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B Mon1 PF03164.14 KII70194.1 - 7.7e-13 48.3 2.0 1e-12 47.9 2.0 1.3 1 0 0 1 1 1 1 Trafficking protein Mon1 Fe-S_biosyn PF01521.20 KII70194.1 - 0.053 13.7 0.7 11 6.2 0.0 2.3 2 0 0 2 2 2 0 Iron-sulphur cluster biosynthesis Hid1 PF12722.7 KII70195.1 - 8.5 4.4 10.5 9.9 4.1 10.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ArfGap PF01412.18 KII70196.1 - 2.6e-35 121.0 0.6 9.5e-35 119.2 0.6 2.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF5623 PF18536.1 KII70196.1 - 0.13 12.6 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5623) RNase_PH PF01138.21 KII70200.1 - 1.1e-09 38.9 0.0 1.5e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Tnp_22_trimer PF17489.2 KII70200.1 - 0.91 9.5 4.3 0.22 11.5 0.9 1.7 2 0 0 2 2 2 0 L1 transposable element trimerization domain MULE PF10551.9 KII70201.1 - 0.00056 20.3 0.1 0.00083 19.7 0.1 1.5 1 1 0 1 1 1 1 MULE transposase domain FF PF01846.19 KII70202.1 - 0.14 12.3 4.5 0.24 11.6 0.2 2.5 3 0 0 3 3 3 0 FF domain HTH_Tnp_Tc5 PF03221.16 KII70203.1 - 3.3e-10 39.8 0.0 8.1e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_22 PF13309.6 KII70203.1 - 0.22 11.6 1.1 10 6.3 0.3 2.9 2 1 1 3 3 3 0 HTH domain Pannexin_like PF12534.8 KII70203.1 - 0.5 9.4 2.0 0.7 8.9 2.0 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 GNT-I PF03071.15 KII70205.1 - 1.5e-13 50.3 1.0 8e-13 47.9 1.0 1.8 1 1 0 1 1 1 1 GNT-I family rve PF00665.26 KII70213.1 - 9.3e-09 35.5 0.0 1.1e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII70213.1 - 0.00025 20.7 0.0 0.00036 20.3 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII70213.1 - 0.21 11.8 0.0 0.26 11.5 0.0 1.1 1 0 0 1 1 1 0 DDE domain DUF3160 PF11369.8 KII70215.1 - 0.11 11.0 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3160) PMG PF05287.12 KII70217.1 - 0.016 15.3 5.6 0.03 14.4 5.6 1.4 1 0 0 1 1 1 0 PMG protein UvrA_DNA-bind PF17755.1 KII70218.1 - 0.47 10.8 3.1 0.31 11.4 0.2 2.1 3 0 0 3 3 3 0 UvrA DNA-binding domain Dimer_Tnp_hAT PF05699.14 KII70221.1 - 0.00093 18.9 0.3 0.0023 17.7 0.3 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Prenyltrans PF00432.21 KII70222.1 - 2.5e-41 139.1 9.8 1.2e-11 44.1 0.5 5.5 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 KII70222.1 - 0.0031 16.7 0.0 0.4 9.7 0.0 2.2 1 1 1 2 2 2 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 KII70222.1 - 0.079 12.0 0.0 2.9 6.9 0.0 2.4 2 1 1 3 3 3 0 Squalene-hopene cyclase C-terminal domain DUF3402 PF11882.8 KII70222.1 - 0.15 11.1 0.2 0.22 10.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) DDE_3 PF13358.6 KII70223.1 - 1.8e-11 44.0 0.1 4e-11 42.9 0.1 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII70223.1 - 4.2e-08 33.7 0.1 0.00021 21.8 0.0 2.5 2 0 0 2 2 2 2 Homeodomain-like domain HTH_29 PF13551.6 KII70223.1 - 2.1e-05 24.4 3.6 0.00024 21.0 0.0 2.7 2 1 1 3 3 3 1 Winged helix-turn helix HTH_33 PF13592.6 KII70223.1 - 0.00045 19.8 0.0 0.00086 18.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.18 KII70223.1 - 0.0062 16.5 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 KII70223.1 - 0.031 14.1 0.0 0.47 10.3 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain HTH_28 PF13518.6 KII70223.1 - 0.051 13.7 0.1 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII70223.1 - 0.079 12.7 0.0 0.39 10.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_ABP1_N PF18107.1 KII70223.1 - 0.1 12.3 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain DDE_3 PF13358.6 KII70224.1 - 1.5e-14 54.0 0.1 2e-14 53.5 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII70225.1 - 1.6e-10 41.4 0.6 3.8e-06 27.4 0.0 2.9 2 1 1 3 3 3 2 Homeodomain-like domain HTH_29 PF13551.6 KII70225.1 - 1.2e-07 31.6 1.9 4.2e-05 23.5 0.0 3.3 3 1 1 4 4 4 1 Winged helix-turn helix PAX PF00292.18 KII70225.1 - 0.003 17.5 0.1 0.0069 16.3 0.1 1.7 1 1 1 2 2 2 1 'Paired box' domain HTH_33 PF13592.6 KII70225.1 - 0.0036 16.9 0.0 0.0074 15.9 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 KII70225.1 - 0.008 15.9 0.0 0.18 11.6 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain HTH_40 PF14493.6 KII70225.1 - 0.0084 16.5 0.2 0.048 14.1 0.0 2.2 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.6 KII70225.1 - 0.015 15.4 0.0 0.08 13.1 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII70225.1 - 0.035 13.8 0.1 0.15 11.7 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_Tnp_Tc3_2 PF01498.18 KII70225.1 - 0.048 13.9 1.1 0.2 11.9 0.1 2.4 2 1 1 3 3 3 0 Transposase Ntox50 PF15542.6 KII70225.1 - 0.12 13.2 2.4 0.56 11.0 1.4 2.2 1 1 1 2 2 2 0 Bacterial toxin 50 RPA_C PF08784.11 KII70225.1 - 0.15 12.7 0.0 0.23 12.1 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal DNA_pol_E_B PF04042.16 KII70226.1 - 2e-25 89.4 0.5 3.5e-25 88.6 0.5 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B LCAT PF02450.15 KII70227.1 - 6.2e-44 150.7 1.3 1.6e-34 119.7 0.3 2.1 1 1 0 2 2 2 2 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 KII70227.1 - 1.9e-06 27.3 0.0 2.9e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 KII70227.1 - 4.7e-06 26.5 0.0 6.9e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 KII70227.1 - 3.8e-05 24.4 0.0 4.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 KII70227.1 - 0.0032 16.8 0.2 0.021 14.1 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.7 KII70227.1 - 0.034 13.9 0.0 0.96 9.2 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family FGase PF05013.12 KII70227.1 - 0.056 13.6 0.0 0.092 12.9 0.0 1.3 1 0 0 1 1 1 0 N-formylglutamate amidohydrolase Esterase PF00756.20 KII70227.1 - 0.095 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF3089 PF11288.8 KII70227.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DDE_3 PF13358.6 KII70229.1 - 0.0019 18.0 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Ank PF00023.30 KII70230.1 - 0.038 14.4 0.6 0.12 12.9 0.1 2.1 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 KII70230.1 - 0.049 14.2 0.2 0.11 13.1 0.2 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KII70230.1 - 0.069 13.7 0.8 0.25 12.0 0.1 2.3 3 0 0 3 3 3 0 Ankyrin repeat IMP_cyclohyd PF07826.11 KII70230.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 IMP cyclohydrolase-like protein Porin_O_P PF07396.11 KII70232.1 - 0.13 11.4 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Phosphate-selective porin O and P KCT2 PF17818.1 KII70234.1 - 0.017 15.3 0.0 0.024 14.7 0.0 1.2 1 0 0 1 1 1 0 Keratinocyte-associated gene product NapE PF06796.11 KII70234.1 - 0.043 13.3 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE BatD PF13584.6 KII70234.1 - 0.059 12.2 0.0 0.084 11.7 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance TMEM223 PF14640.6 KII70234.1 - 0.061 13.5 0.3 0.12 12.5 0.1 1.5 2 0 0 2 2 2 0 Transmembrane protein 223 Orf78 PF06024.12 KII70234.1 - 0.072 13.4 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Orf78 (ac78) DUF1189 PF06691.11 KII70234.1 - 0.68 9.5 6.5 4.9 6.6 6.5 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1189) SNARE PF05739.19 KII70234.1 - 1.5 8.9 4.7 4.9 7.2 4.7 2.0 1 1 0 1 1 1 0 SNARE domain IU_nuc_hydro PF01156.19 KII70235.1 - 1e-36 127.1 0.0 1.2e-36 126.8 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF4863 PF16155.5 KII70235.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4863) MLVIN_C PF18697.1 KII70240.1 - 0.00037 20.5 0.0 0.00059 19.9 0.0 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVP_2 PF08284.11 KII70241.1 - 1.8e-10 40.7 0.1 3.4e-10 39.8 0.1 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII70241.1 - 3.5e-05 24.3 0.0 7.8e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII70241.1 - 0.00014 21.6 0.0 0.0005 19.9 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease Asp_protease_2 PF13650.6 KII70241.1 - 0.00069 20.2 0.0 0.002 18.7 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease RPAP2_Rtr1 PF04181.13 KII70241.1 - 0.034 14.5 0.1 0.034 14.5 0.1 2.3 2 0 0 2 2 2 0 Rtr1/RPAP2 family NCBP3 PF10309.9 KII70241.1 - 0.042 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 RT_RNaseH_2 PF17919.1 KII70242.1 - 7.7e-23 80.4 0.0 1.8e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII70242.1 - 1.1e-22 80.3 0.0 2.2e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII70242.1 - 6.9e-19 68.2 0.0 1.6e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70242.1 - 1.6e-08 34.5 0.1 3.2e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain MLVIN_C PF18697.1 KII70242.1 - 0.0044 17.1 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVT_thumb PF06817.14 KII70242.1 - 0.024 14.5 0.0 0.057 13.3 0.0 1.7 1 0 0 1 1 1 0 Reverse transcriptase thumb domain DUF4755 PF15947.5 KII70242.1 - 4 7.4 7.6 0.22 11.5 1.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4755) PH PF00169.29 KII70245.1 - 4.9e-13 49.5 0.3 1.4e-12 48.0 0.3 1.9 1 0 0 1 1 1 1 PH domain START PF01852.19 KII70245.1 - 3.7e-06 26.5 0.0 4.5e-05 23.0 0.0 2.3 1 1 0 1 1 1 1 START domain PH_11 PF15413.6 KII70245.1 - 0.00048 20.5 5.5 0.0056 17.1 1.5 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 KII70245.1 - 0.00061 20.0 0.3 0.0015 18.8 0.3 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 KII70245.1 - 0.00075 19.8 0.0 0.0018 18.5 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain MnmE_helical PF12631.7 KII70245.1 - 0.0017 18.5 0.1 0.1 12.7 0.0 2.7 3 0 0 3 3 3 1 MnmE helical domain THOC7 PF05615.13 KII70245.1 - 0.0066 16.7 1.4 0.018 15.3 0.4 2.1 2 0 0 2 2 2 1 Tho complex subunit 7 DUF713 PF05218.14 KII70245.1 - 0.019 14.7 6.1 0.058 13.1 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF713) DUF2570 PF10828.8 KII70245.1 - 0.033 14.0 0.6 0.092 12.6 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) EzrA PF06160.12 KII70245.1 - 0.04 12.1 3.1 0.64 8.1 0.1 2.2 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA FliS PF02561.14 KII70245.1 - 0.094 13.0 0.4 0.75 10.1 0.1 2.3 2 0 0 2 2 2 0 Flagellar protein FliS HeLo PF14479.6 KII70245.1 - 0.12 12.2 1.3 0.81 9.5 0.1 2.2 2 0 0 2 2 2 0 Prion-inhibition and propagation IFT57 PF10498.9 KII70245.1 - 0.14 11.1 4.9 0.15 11.0 2.2 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF4201 PF13870.6 KII70245.1 - 0.18 11.5 5.0 10 5.8 3.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) FlxA PF14282.6 KII70245.1 - 0.61 10.1 5.2 4.5 7.3 0.3 2.5 2 0 0 2 2 2 0 FlxA-like protein SR-25 PF10500.9 KII70245.1 - 1.6 8.3 12.2 1.9 8.1 6.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Prefoldin PF02996.17 KII70245.1 - 2.8 7.9 7.6 8.8 6.3 3.7 2.6 2 0 0 2 2 2 0 Prefoldin subunit IFT20 PF14931.6 KII70245.1 - 8.4 6.6 9.1 8 6.7 5.4 2.8 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 DDE_3 PF13358.6 KII70247.1 - 1.2e-05 25.1 0.0 2.1e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease BBS1 PF14779.6 KII70247.1 - 0.08 12.4 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 rve_2 PF13333.6 KII70248.1 - 0.064 13.4 1.2 0.12 12.6 0.3 1.8 1 1 1 2 2 2 0 Integrase core domain ApoO PF09769.9 KII70248.1 - 0.1 12.6 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Apolipoprotein O zf-CCHC_3 PF13917.6 KII70248.1 - 7.1 6.7 7.7 7.2 6.7 0.5 2.9 3 0 0 3 3 3 0 Zinc knuckle RT_RNaseH_2 PF17919.1 KII70249.1 - 2.6e-08 33.8 0.0 3.9e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII70249.1 - 0.014 15.7 0.0 0.019 15.2 0.0 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Peptidase_A17 PF05380.13 KII70249.1 - 0.067 13.2 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Pao retrotransposon peptidase TraT PF05818.12 KII70251.1 - 0.016 14.9 0.1 0.025 14.2 0.1 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein AAA_2 PF07724.14 KII70252.1 - 2.2e-29 102.7 0.0 2.7e-29 102.5 0.0 1.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KII70252.1 - 4.6e-07 29.9 0.0 5.9e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KII70252.1 - 0.01 15.7 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) GhoS PF11080.8 KII70252.1 - 0.03 14.3 0.0 0.04 13.9 0.0 1.2 1 0 0 1 1 1 0 Endoribonuclease GhoS DDE_3 PF13358.6 KII70253.1 - 0.0015 18.3 0.2 0.13 12.1 0.2 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease SNF2_N PF00176.23 KII70257.1 - 3.7e-20 72.0 0.1 6.7e-20 71.1 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HDA2-3 PF11496.8 KII70257.1 - 0.00082 18.6 0.2 0.0016 17.7 0.2 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 C2 PF00168.30 KII70261.1 - 2.2e-13 50.4 0.3 3.5e-12 46.5 0.1 2.2 2 0 0 2 2 2 1 C2 domain C2 PF00168.30 KII70262.1 - 2.4e-06 27.8 0.0 9.4e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 C2 domain Ferlin_C PF16165.5 KII70263.1 - 1.9e-10 40.9 0.2 2.7e-06 27.4 0.0 2.2 1 1 1 2 2 2 2 Ferlin C-terminus C2 PF00168.30 KII70263.1 - 0.00015 22.0 0.0 0.00081 19.6 0.0 2.0 1 1 1 2 2 2 1 C2 domain tRNA-synt_2 PF00152.20 KII70264.1 - 1.2e-75 254.5 0.2 1.5e-75 254.2 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KII70264.1 - 5.6e-10 39.1 0.2 2.1e-09 37.2 0.1 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KII70264.1 - 1.9e-08 34.1 0.0 0.001 18.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) ubiquitin PF00240.23 KII70266.1 - 1.1e-13 50.7 0.7 3.3e-09 36.4 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 KII70266.1 - 7.1e-13 48.2 4.8 2.9e-06 27.0 0.8 2.3 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like BTB_2 PF02214.22 KII70267.1 - 0.11 12.8 1.1 0.14 12.5 0.7 1.5 1 1 0 1 1 1 0 BTB/POZ domain Sortilin-Vps10 PF15902.5 KII70268.1 - 1.9e-08 33.6 1.6 3.1e-08 32.8 1.6 1.3 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII70268.1 - 2.3e-06 26.7 3.3 1.6 9.1 0.0 4.4 5 0 0 5 5 5 3 BNR/Asp-box repeat Mo-co_dimer PF03404.16 KII70268.1 - 0.045 13.8 0.4 6.2 6.8 0.0 3.0 2 1 1 3 3 3 0 Mo-co oxidoreductase dimerisation domain BNR PF02012.20 KII70269.1 - 8e-05 22.1 3.1 0.099 12.7 0.1 3.1 3 0 0 3 3 3 2 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII70269.1 - 0.018 13.8 0.3 0.025 13.4 0.3 1.2 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, PurA PF04845.13 KII70270.1 - 8.3e-10 38.4 3.3 5.4e-06 25.9 0.2 2.7 1 1 2 3 3 3 3 PurA ssDNA and RNA-binding protein Glyco_hydro_97 PF10566.9 KII70271.1 - 0.072 12.4 0.0 0.087 12.1 0.0 1.1 1 0 0 1 1 1 0 Glycoside hydrolase 97 HMD PF03201.16 KII70271.1 - 0.21 11.9 0.0 31 4.9 0.0 2.4 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase DDE_3 PF13358.6 KII70273.1 - 1.9e-10 40.7 0.0 3.4e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Nop52 PF05997.12 KII70274.1 - 1e-33 117.0 5.9 1.5e-33 116.5 5.8 1.3 1 1 0 1 1 1 1 Nucleolar protein,Nop52 CRM1_C PF08767.11 KII70274.1 - 0.029 13.6 11.0 0.08 12.1 11.0 1.7 1 1 0 1 1 1 0 CRM1 C terminal DDE_3 PF13358.6 KII70275.1 - 5.4e-14 52.2 0.1 1.2e-13 51.0 0.1 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII70275.1 - 2.7e-10 40.7 0.5 1.3e-05 25.7 0.0 2.9 1 1 2 3 3 3 2 Homeodomain-like domain HTH_29 PF13551.6 KII70275.1 - 1.5e-07 31.4 0.6 3.8e-06 26.8 0.0 3.0 2 1 1 3 3 3 1 Winged helix-turn helix HTH_23 PF13384.6 KII70275.1 - 0.00038 20.2 0.0 0.0042 16.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 KII70275.1 - 0.00062 19.8 0.0 0.0022 18.1 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII70275.1 - 0.001 19.0 0.0 0.0026 17.7 0.0 1.7 1 1 0 1 1 1 1 'Paired box' domain Sigma70_r4_2 PF08281.12 KII70275.1 - 0.0016 18.1 0.0 0.0052 16.4 0.0 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_40 PF14493.6 KII70275.1 - 0.0017 18.7 0.2 0.0084 16.5 0.0 2.2 2 1 1 3 3 2 1 Helix-turn-helix domain HTH_33 PF13592.6 KII70275.1 - 0.0037 16.9 0.1 0.019 14.6 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_38 PF13936.6 KII70275.1 - 0.017 14.9 0.1 0.29 10.9 0.0 2.7 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 KII70275.1 - 0.033 13.6 0.0 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Ntox50 PF15542.6 KII70275.1 - 0.11 13.3 1.1 0.42 11.5 1.0 2.1 1 1 0 1 1 1 0 Bacterial toxin 50 DDE_3 PF13358.6 KII70276.1 - 1.8e-11 44.0 0.1 4e-11 42.9 0.1 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII70276.1 - 4.2e-08 33.7 0.1 0.00021 21.8 0.0 2.5 2 0 0 2 2 2 2 Homeodomain-like domain HTH_29 PF13551.6 KII70276.1 - 2.1e-05 24.4 3.6 0.00024 21.0 0.0 2.7 2 1 1 3 3 3 1 Winged helix-turn helix HTH_33 PF13592.6 KII70276.1 - 0.00045 19.8 0.0 0.00086 18.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.18 KII70276.1 - 0.0062 16.5 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 KII70276.1 - 0.031 14.1 0.0 0.47 10.3 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain HTH_28 PF13518.6 KII70276.1 - 0.051 13.7 0.1 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII70276.1 - 0.079 12.7 0.0 0.39 10.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_ABP1_N PF18107.1 KII70276.1 - 0.1 12.3 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain Dimer_Tnp_hAT PF05699.14 KII70277.1 - 0.1 12.4 0.0 0.4 10.5 0.0 2.0 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region PTS_EIIA_2 PF00359.22 KII70278.1 - 0.035 14.0 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 DUF4922 PF16269.5 KII70278.1 - 0.047 13.5 0.2 0.095 12.5 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4922) SH3_9 PF14604.6 KII70278.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain Dynactin_p22 PF07426.11 KII70278.1 - 0.14 12.0 2.0 0.21 11.5 2.0 1.2 1 0 0 1 1 1 0 Dynactin subunit p22 zf-H2C2_2 PF13465.6 KII70279.1 - 7.9e-14 51.4 19.0 2.8e-06 27.5 0.6 4.8 4 1 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 KII70279.1 - 1.4e-12 47.3 25.0 2.5e-07 30.8 2.8 6.0 6 0 0 6 6 6 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII70279.1 - 4.3e-11 42.7 21.4 0.0014 19.3 1.9 6.2 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KII70279.1 - 1.9e-05 24.8 17.4 0.0029 17.9 1.4 5.6 6 0 0 6 6 6 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KII70279.1 - 0.00064 19.6 21.3 0.002 18.1 2.1 5.0 5 0 0 5 5 5 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KII70279.1 - 0.0018 18.6 4.2 1.8 8.9 0.4 4.1 1 1 3 4 4 4 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KII70279.1 - 0.026 14.9 19.0 0.44 11.0 2.0 4.7 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 KII70279.1 - 0.036 14.0 1.6 0.54 10.2 0.2 2.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Yippee-Mis18 PF03226.14 KII70279.1 - 0.042 14.1 0.4 0.098 12.9 0.4 1.6 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DiS_P_DiS PF06750.13 KII70279.1 - 0.056 13.6 0.2 0.14 12.3 0.2 1.7 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain zf-C2H2_11 PF16622.5 KII70279.1 - 0.057 13.2 0.4 0.057 13.2 0.4 5.0 5 0 0 5 5 5 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 KII70279.1 - 0.11 12.7 5.2 6.8 6.9 0.2 3.4 3 0 0 3 3 3 0 Zinc ribbon domain zf-Di19 PF05605.12 KII70279.1 - 0.13 12.6 3.3 7.8 6.9 0.1 3.0 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 KII70279.1 - 0.16 12.4 5.2 11 6.6 0.1 3.5 3 1 1 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf_PR_Knuckle PF18445.1 KII70279.1 - 0.18 11.6 3.2 0.56 10.1 0.0 2.8 3 0 0 3 3 3 0 PR zinc knuckle motif zf-H2C2_5 PF13909.6 KII70279.1 - 0.59 9.9 11.6 0.92 9.3 4.5 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-3CxxC_2 PF17180.4 KII70279.1 - 1.9 9.3 7.8 30 5.5 0.1 3.5 3 1 0 3 3 3 0 Zinc-binding domain zf-HIT PF04438.16 KII70279.1 - 2.2 8.2 5.7 2.4 8.1 0.2 3.1 3 0 0 3 3 3 0 HIT zinc finger zf-CCHC_2 PF13696.6 KII70279.1 - 4.7 7.1 7.2 17 5.4 0.4 3.3 3 0 0 3 3 3 0 Zinc knuckle zf_UBZ PF18439.1 KII70279.1 - 8.3 6.1 7.5 2 8.1 0.1 3.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger PGM_PMM_IV PF00408.20 KII70280.1 - 7.4e-09 35.7 0.0 1.5e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 KII70280.1 - 0.041 14.5 0.1 0.15 12.7 0.0 2.0 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DEAD PF00270.29 KII70281.1 - 6.7e-49 166.0 0.0 2.4e-48 164.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII70281.1 - 1.7e-26 92.7 0.0 1.5e-25 89.7 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CS PF04969.16 KII70282.1 - 0.00053 21.0 0.2 0.0027 18.7 0.2 2.3 1 0 0 1 1 1 1 CS domain Kinesin PF00225.23 KII70283.1 - 5.4e-114 380.6 0.6 5.4e-114 380.6 0.6 2.7 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KII70283.1 - 2e-25 89.5 0.1 9.5e-25 87.3 0.1 2.3 1 0 0 1 1 1 1 Microtubule binding SCO1-SenC PF02630.14 KII70283.1 - 0.27 11.2 1.2 32 4.4 0.0 4.2 5 0 0 5 5 5 0 SCO1/SenC Baculo_PEP_C PF04513.12 KII70283.1 - 0.42 10.6 23.8 0.57 10.2 0.2 5.9 1 1 5 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exonuc_VII_S PF02609.16 KII70283.1 - 0.48 10.5 3.2 35 4.6 0.2 3.5 3 0 0 3 3 3 0 Exonuclease VII small subunit PRD PF00874.20 KII70283.1 - 2.4 8.5 8.5 3.7 7.9 0.3 4.2 3 2 1 4 4 4 0 PRD domain DUF1664 PF07889.12 KII70283.1 - 2.7 8.0 26.8 9.5 6.3 1.4 6.6 2 2 1 6 6 6 0 Protein of unknown function (DUF1664) Rx_N PF18052.1 KII70283.1 - 4.8 7.5 6.4 10 6.5 0.7 3.6 2 0 0 2 2 2 0 Rx N-terminal domain UQ_con PF00179.26 KII70284.1 - 2.6e-49 166.4 0.8 3e-49 166.3 0.1 1.4 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KII70284.1 - 0.00015 21.4 0.0 0.00031 20.5 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KII70284.1 - 0.0052 17.0 0.0 0.008 16.5 0.0 1.4 1 0 0 1 1 1 1 RWD domain Nup160 PF11715.8 KII70284.1 - 0.088 11.4 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Complex1_30kDa PF00329.19 KII70285.1 - 2.7e-40 137.8 0.0 3.7e-40 137.3 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF2087 PF09860.9 KII70285.1 - 0.15 12.2 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) CLTH PF10607.9 KII70286.1 - 0.058 13.3 0.4 0.077 12.9 0.4 1.1 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain MEF2_binding PF09047.10 KII70287.1 - 0.028 14.3 0.5 0.059 13.2 0.5 1.6 1 0 0 1 1 1 0 MEF2 binding Bax1-I PF01027.20 KII70288.1 - 1.5e-15 57.6 23.5 1.7e-15 57.4 23.5 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2070 PF09843.9 KII70288.1 - 0.11 10.8 22.8 0.12 10.6 22.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) AzlC PF03591.14 KII70288.1 - 0.11 12.9 11.6 0.17 12.3 11.6 1.3 1 1 0 1 1 1 0 AzlC protein DUF3784 PF12650.7 KII70288.1 - 4.5 7.5 22.2 2.5 8.4 9.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) YmgB PF10798.8 KII70289.1 - 1.5e-23 82.3 3.5 2.3e-21 75.3 1.1 2.9 3 0 0 3 3 3 2 Biofilm development protein YmgB/AriR MtlR PF05068.12 KII70289.1 - 0.075 13.1 0.0 3.2 7.7 0.0 2.2 2 0 0 2 2 2 0 Mannitol repressor RT_RNaseH PF17917.1 KII70298.1 - 4.2e-33 113.8 0.0 6.8e-33 113.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII70298.1 - 6.7e-33 112.7 0.1 1.1e-32 112.1 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70298.1 - 2.2e-25 89.5 0.0 4.2e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII70299.1 - 6.9e-08 32.7 0.0 2.4e-07 30.9 0.0 1.9 1 1 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70299.1 - 6.1e-05 23.1 0.5 0.00017 21.6 0.5 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_Tnp_IS1595 PF12762.7 KII70302.1 - 6.2e-09 36.0 0.0 6.4e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII70303.1 - 2.2e-08 33.9 0.0 3.4e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Ccdc124 PF06244.12 KII70307.1 - 9e-18 65.1 0.2 9.5e-18 65.0 0.2 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 YABBY PF04690.13 KII70307.1 - 0.0088 16.6 0.3 0.0091 16.6 0.3 1.3 1 1 0 1 1 1 1 YABBY protein EF-hand_7 PF13499.6 KII70308.1 - 2.6e-08 34.2 7.9 9.3e-05 22.8 1.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KII70308.1 - 3.5e-07 29.3 4.3 0.014 14.9 0.2 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KII70308.1 - 1.3e-06 27.9 2.7 0.061 13.3 0.2 3.5 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KII70308.1 - 0.00012 21.4 4.0 0.086 12.4 0.4 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KII70308.1 - 0.003 17.4 2.9 1.9 8.4 0.1 3.7 3 1 1 4 4 4 2 EF-hand domain pair ComC PF03047.14 KII70308.1 - 0.017 14.9 0.1 2.3 8.1 0.1 2.4 2 0 0 2 2 2 0 COMC family Sortilin_C PF15901.5 KII70311.1 - 5.8e-10 39.8 5.3 8.9e-10 39.2 5.3 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII70311.1 - 0.014 14.2 0.0 0.036 12.9 0.0 1.6 2 0 0 2 2 2 0 Sortilin, neurotensin receptor 3, DDE_3 PF13358.6 KII70314.1 - 5.7e-15 55.3 0.1 7.2e-15 55.0 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF89 PF01937.19 KII70314.1 - 0.076 11.9 0.1 0.089 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF89 DUF1491 PF07372.12 KII70315.1 - 0.21 12.0 0.0 0.26 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) CBFD_NFYB_HMF PF00808.23 KII70316.1 - 7.6e-08 32.5 0.1 2.7e-07 30.8 0.0 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TMPIT PF07851.13 KII70316.1 - 1.1 8.5 4.9 1.4 8.1 4.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein PIN_12 PF16289.5 KII70316.1 - 3.8 8.0 9.0 5.6 7.4 6.3 2.0 1 1 1 2 2 2 0 PIN domain Choline_kinase PF01633.20 KII70317.1 - 0.05 13.2 0.1 0.064 12.8 0.1 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase gag-asp_proteas PF13975.6 KII70317.1 - 0.12 12.9 0.1 0.26 11.9 0.1 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease FG-GAP PF01839.23 KII70319.1 - 6.9e-10 38.9 4.4 0.00059 19.9 0.1 2.6 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.6 KII70319.1 - 2e-08 34.7 1.1 5.6e-08 33.2 1.1 1.9 1 0 0 1 1 1 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 KII70319.1 - 0.16 11.3 0.6 9 5.6 0.0 2.3 1 1 1 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region DUF2678 PF10856.8 KII70320.1 - 0.12 12.3 1.3 0.18 11.7 1.1 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2678) DUF4050 PF13259.6 KII70322.1 - 2.8 8.2 8.0 0.27 11.5 2.8 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4050) HATPase_c_3 PF13589.6 KII70326.1 - 1.1e-12 47.9 0.1 1.9e-12 47.2 0.1 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KII70326.1 - 7.8e-07 29.6 0.2 1.7e-06 28.5 0.1 1.7 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 KII70327.1 - 5.9e-25 87.7 0.1 3e-22 79.0 0.0 2.4 1 1 1 2 2 2 2 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 KII70327.1 - 0.0016 18.1 0.0 0.0038 16.9 0.0 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Siah-Interact_N PF09032.11 KII70330.1 - 0.62 10.4 3.5 1.1 9.7 0.0 2.7 2 1 1 3 3 3 0 Siah interacting protein, N terminal RhoGEF PF00621.20 KII70332.1 - 1.3e-28 100.5 5.1 1.9e-28 99.9 5.1 1.2 1 0 0 1 1 1 1 RhoGEF domain RT_RNaseH PF17917.1 KII70333.1 - 1.2e-22 80.1 0.1 1.8e-22 79.6 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII70333.1 - 1.7e-19 69.7 0.0 3.1e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII70334.1 - 9.8e-17 61.3 0.0 1.5e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII70334.1 - 0.00022 20.9 0.0 0.00043 20.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII70334.1 - 0.017 15.2 0.0 0.049 13.7 0.0 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DUF4158 PF13700.6 KII70336.1 - 0.017 14.9 0.2 0.021 14.7 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4158) DUF1871 PF08958.10 KII70336.1 - 0.028 14.7 0.0 0.067 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1871) rve PF00665.26 KII70337.1 - 4.4e-16 59.1 0.1 5.5e-16 58.8 0.1 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII70337.1 - 0.0085 15.9 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Tricho_coat PF05892.11 KII70337.1 - 0.028 14.2 0.1 0.034 13.9 0.1 1.1 1 0 0 1 1 1 0 Trichovirus coat protein Integrase_H2C2 PF17921.1 KII70338.1 - 8.4e-12 45.0 0.1 1.3e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 KII70338.1 - 4.4e-07 30.1 0.4 1.1e-06 28.9 0.1 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Asp_protease PF09668.10 KII70339.1 - 0.00027 20.7 0.1 0.00045 20.0 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII70339.1 - 0.0034 17.7 0.0 0.0062 16.8 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KII70339.1 - 0.004 16.9 0.1 0.0081 15.9 0.1 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII70339.1 - 0.073 13.6 0.1 0.13 12.9 0.1 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_2 PF13696.6 KII70339.1 - 0.33 10.8 2.5 0.85 9.5 2.5 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII70339.1 - 5.7 6.8 10.0 0.89 9.3 1.8 2.7 2 0 0 2 2 2 0 Zinc knuckle SwrA PF17423.2 KII70340.1 - 0.023 14.7 0.9 0.039 13.9 0.9 1.5 1 0 0 1 1 1 0 Swarming motility protein DUF4600 PF15372.6 KII70344.1 - 0.024 15.1 0.0 0.038 14.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) GTP_EFTU PF00009.27 KII70345.1 - 2.2e-20 73.0 0.0 3.4e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KII70345.1 - 1.9e-10 41.0 0.1 3.2e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.5 KII70345.1 - 0.027 14.5 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 KII70345.1 - 0.048 13.6 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase DAO_C PF16901.5 KII70347.1 - 2.8e-27 95.1 0.0 4.2e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase DAO PF01266.24 KII70347.1 - 4.2e-15 56.2 0.0 5.5e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Nodulin PF02451.15 KII70347.1 - 0.016 14.7 0.0 0.033 13.7 0.0 1.5 1 0 0 1 1 1 0 Nodulin CHU_C PF13585.6 KII70347.1 - 0.072 13.2 0.2 0.31 11.1 0.1 2.1 2 0 0 2 2 2 0 C-terminal domain of CHU protein family GPP34 PF05719.11 KII70349.1 - 2.2e-35 122.5 0.0 2.9e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) RunxI PF08504.11 KII70349.1 - 0.16 12.7 0.0 0.29 11.8 0.0 1.4 1 0 0 1 1 1 0 Runx inhibition domain HMG_box PF00505.19 KII70351.1 - 3e-18 66.0 0.8 3e-18 66.0 0.8 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KII70351.1 - 1.9e-06 28.3 0.2 5.3e-06 26.9 0.2 1.7 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 KII70351.1 - 0.0012 18.8 0.0 0.0031 17.4 0.0 1.7 1 0 0 1 1 1 1 CHDNT (NUC034) domain WD40 PF00400.32 KII70352.1 - 3e-06 27.9 0.7 0.0013 19.6 0.4 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII70352.1 - 0.043 14.1 0.1 0.33 11.3 0.0 2.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain HhH-GPD PF00730.25 KII70353.1 - 2.9e-12 47.0 0.0 1.1e-11 45.1 0.0 2.0 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KII70353.1 - 0.0002 21.1 0.0 0.00047 19.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.7 KII70353.1 - 0.061 13.4 0.0 0.56 10.3 0.0 2.5 3 1 0 3 3 3 0 Helix-hairpin-helix motif HHH_5 PF14520.6 KII70353.1 - 0.11 13.1 0.0 3.7 8.2 0.0 2.6 2 1 1 3 3 3 0 Helix-hairpin-helix domain FLYWCH PF04500.16 KII70354.1 - 3.2e-07 30.3 2.2 4.8e-07 29.8 2.2 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain zf-primase PF09329.11 KII70355.1 - 0.00025 20.8 0.3 0.0019 17.9 0.2 2.2 2 0 0 2 2 2 1 Primase zinc finger Mcm10 PF09332.11 KII70356.1 - 0.071 12.5 14.5 0.12 11.8 14.5 1.3 1 1 0 1 1 1 0 Mcm10 replication factor GH97_C PF14509.6 KII70356.1 - 0.077 13.2 0.5 0.077 13.2 0.5 1.7 2 0 0 2 2 2 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation DUF733 PF05306.11 KII70356.1 - 0.72 10.2 6.3 0.42 11.0 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF733) Homeodomain PF00046.29 KII70357.1 - 1.9e-16 59.6 8.3 3.3e-16 58.9 8.3 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KII70357.1 - 0.1 12.6 0.5 0.23 11.4 0.5 1.7 1 0 0 1 1 1 0 Homeobox KN domain SRAP PF02586.14 KII70359.1 - 5.8e-43 147.0 0.0 7e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) PRR20 PF15708.5 KII70359.1 - 0.17 11.7 0.0 0.25 11.2 0.0 1.1 1 0 0 1 1 1 0 Proline-rich protein family 20 HSP70 PF00012.20 KII70360.1 - 5e-244 811.0 5.8 5.7e-244 810.8 5.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KII70360.1 - 1.5e-14 53.6 0.4 1.3e-13 50.4 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KII70360.1 - 0.0032 17.2 0.0 0.0063 16.3 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF4845 PF16137.5 KII70360.1 - 0.018 15.9 0.0 0.068 14.0 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4845) DDR PF08841.10 KII70360.1 - 0.025 13.6 0.1 0.44 9.5 0.0 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 KII70360.1 - 0.089 12.0 0.1 0.2 10.9 0.1 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase FtsA PF14450.6 KII70360.1 - 0.54 10.7 5.5 7.2 7.1 0.1 3.6 3 1 0 3 3 3 0 Cell division protein FtsA Inhibitor_I29 PF08246.12 KII70361.1 - 1.3e-06 28.7 1.5 2.1e-06 28.1 1.5 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.23 KII70361.1 - 0.0045 17.1 0.0 0.0092 16.1 0.0 1.5 1 0 0 1 1 1 1 Papain family cysteine protease SCO1-SenC PF02630.14 KII70362.1 - 1.4e-34 118.9 0.0 1.9e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.6 KII70362.1 - 0.019 15.3 0.1 0.044 14.1 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin-like IMPDH PF00478.25 KII70363.1 - 5.1e-90 302.0 3.4 6e-90 301.7 3.4 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KII70363.1 - 1.7e-10 40.5 0.4 2.5e-10 39.9 0.4 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 KII70363.1 - 4.4e-07 29.6 1.5 6.3e-07 29.1 1.5 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 KII70363.1 - 3e-05 23.6 2.1 0.015 14.8 0.2 2.2 1 1 1 2 2 2 2 Histidine biosynthesis protein CBS PF00571.28 KII70363.1 - 4.2e-05 23.9 0.0 0.00016 22.0 0.0 2.0 2 0 0 2 2 2 1 CBS domain NanE PF04131.14 KII70363.1 - 0.00019 20.7 0.4 0.00031 20.0 0.4 1.3 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.14 KII70363.1 - 0.0014 17.9 1.1 0.0048 16.2 1.1 1.9 1 1 0 1 1 1 1 Thiazole biosynthesis protein ThiG Dus PF01207.17 KII70363.1 - 0.0025 17.0 1.9 0.099 11.7 0.1 2.1 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) IGPS PF00218.21 KII70363.1 - 0.031 13.4 0.2 0.23 10.6 0.0 2.1 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase DUF561 PF04481.12 KII70363.1 - 0.032 13.4 1.5 0.063 12.4 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF561) TMP-TENI PF02581.17 KII70363.1 - 0.058 12.7 1.4 0.21 10.9 0.6 2.2 2 1 1 3 3 3 0 Thiamine monophosphate synthase PcrB PF01884.17 KII70363.1 - 0.18 11.2 0.9 0.66 9.4 0.1 2.3 2 1 1 3 3 3 0 PcrB family DHO_dh PF01180.21 KII70363.1 - 0.4 9.8 4.9 0.91 8.7 0.6 2.5 2 1 1 3 3 3 0 Dihydroorotate dehydrogenase IMPDH PF00478.25 KII70364.1 - 1.9e-29 102.8 0.0 2e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Sm_like PF16243.5 KII70364.1 - 0.13 12.4 0.1 0.63 10.2 0.0 1.9 1 1 1 2 2 2 0 Sm_like domain SNAP PF14938.6 KII70366.1 - 5.9e-06 25.9 0.2 8.6e-06 25.4 0.2 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP OKR_DC_1 PF01276.20 KII70366.1 - 0.16 10.7 0.1 0.21 10.3 0.1 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Homeodomain PF00046.29 KII70367.1 - 1.4e-17 63.3 5.6 2.1e-17 62.7 5.6 1.3 1 0 0 1 1 1 1 Homeodomain Ubiquitin_5 PF18037.1 KII70367.1 - 0.073 13.4 0.8 0.098 13.0 0.8 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain BrkDBD PF09607.10 KII70367.1 - 0.091 12.5 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Brinker DNA-binding domain CWC25 PF12542.8 KII70369.1 - 6.2e-14 52.8 0.0 6.2e-14 52.8 0.0 2.6 3 1 0 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.9 KII70369.1 - 5.2e-13 48.9 8.5 5.2e-13 48.9 8.5 3.5 3 0 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR DUF5499 PF17603.2 KII70369.1 - 0.097 13.3 1.3 0.28 11.8 0.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5499) Pet20 PF08692.10 KII70369.1 - 0.72 10.6 4.6 22 5.8 0.9 3.1 1 1 1 2 2 2 0 Mitochondrial protein Pet20 E1-E2_ATPase PF00122.20 KII70370.1 - 3.2e-51 173.4 0.5 6.3e-51 172.5 0.5 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KII70370.1 - 6.4e-38 130.3 8.3 7e-38 130.1 2.9 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 KII70370.1 - 2.8e-21 75.4 0.1 5.8e-21 74.4 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KII70370.1 - 8.6e-17 62.1 0.1 8.3e-16 58.9 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KII70370.1 - 5.6e-07 29.5 1.4 8.5e-06 25.7 0.6 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KII70370.1 - 0.0034 17.8 0.0 0.0086 16.5 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3027 PF11228.8 KII70371.1 - 0.081 12.9 0.1 0.096 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) PROL5-SMR PF15621.6 KII70371.1 - 0.13 12.8 6.6 0.18 12.3 6.6 1.4 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family KTI12 PF08433.10 KII70372.1 - 1.6e-49 168.8 0.2 1.9e-49 168.6 0.2 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 KII70372.1 - 0.00018 21.7 0.0 0.00042 20.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.20 KII70372.1 - 0.0039 17.1 0.0 0.019 14.9 0.0 2.1 1 1 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 KII70372.1 - 0.019 15.5 0.0 0.034 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KII70372.1 - 0.029 14.7 0.0 0.097 12.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KII70372.1 - 0.06 12.7 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MMR_HSR1 PF01926.23 KII70372.1 - 0.12 12.5 0.2 0.56 10.3 0.2 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 KII70372.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin HMG_box PF00505.19 KII70373.1 - 8.1e-20 71.0 1.8 8.1e-20 71.0 1.8 2.4 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KII70373.1 - 5.8e-08 33.2 0.4 5.8e-08 33.2 0.4 2.4 1 1 1 2 2 2 1 HMG-box domain RNase_HII PF01351.18 KII70375.1 - 1.3e-41 142.6 0.0 1.6e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII DDE_Tnp_IS1595 PF12762.7 KII70376.1 - 1.1e-14 54.7 0.0 1.8e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain zf-MIZ PF02891.20 KII70377.1 - 2.3e-12 46.5 8.0 4.2e-12 45.6 8.0 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KII70377.1 - 2.3e-05 24.1 3.4 6.4e-05 22.7 3.4 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit End_tail_spike PF12219.8 KII70377.1 - 0.0028 17.7 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 Catalytic domain of bacteriophage endosialidase zf-RING_UBOX PF13445.6 KII70377.1 - 0.5 10.4 8.2 0.82 9.7 2.6 2.6 2 0 0 2 2 2 0 RING-type zinc-finger Prok-RING_4 PF14447.6 KII70377.1 - 0.65 9.9 5.8 0.58 10.1 3.1 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KII70377.1 - 1.3 9.0 11.3 0.66 9.9 8.3 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SCO1-SenC PF02630.14 KII70378.1 - 4.6e-47 159.3 0.0 6.2e-47 158.9 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC MIF4G_like_2 PF09090.11 KII70380.1 - 1.7e-17 63.8 3.1 4.9e-17 62.3 3.1 1.7 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.19 KII70380.1 - 1.8e-10 40.8 4.5 1.8e-10 40.8 4.5 2.7 4 0 0 4 4 4 1 MIF4G domain MIF4G_like PF09088.11 KII70380.1 - 1.7e-09 37.7 0.6 4e-09 36.5 0.6 1.6 1 0 0 1 1 1 1 MIF4G like DUF3385 PF11865.8 KII70380.1 - 0.0077 16.2 1.2 4.2 7.3 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF3385) W2 PF02020.18 KII70380.1 - 0.012 15.8 0.1 0.073 13.2 0.1 2.4 1 0 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon UFD1 PF03152.14 KII70381.1 - 3.3e-43 147.2 0.0 4.9e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 HTH_Tnp_Tc3_2 PF01498.18 KII70382.1 - 0.00043 20.5 0.1 0.00078 19.6 0.1 1.3 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 KII70382.1 - 0.031 14.9 0.0 0.043 14.4 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain IBR PF01485.21 KII70383.1 - 2.5e-17 62.8 21.4 4e-12 46.2 9.0 4.1 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 KII70383.1 - 0.00018 21.4 11.7 0.00018 21.4 11.7 4.4 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 KII70383.1 - 0.0016 18.8 13.0 0.0016 18.8 13.0 4.1 3 1 1 4 4 4 1 Ring finger domain PFU PF09070.11 KII70384.1 - 3.2e-29 101.5 0.2 7.7e-29 100.3 0.2 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 KII70384.1 - 1.1e-15 57.7 10.5 0.0027 18.5 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat PUL PF08324.11 KII70384.1 - 1.5e-07 31.0 0.3 2.4e-07 30.3 0.3 1.3 1 0 0 1 1 1 1 PUL domain WD40_like PF17005.5 KII70384.1 - 0.0073 15.7 0.2 0.04 13.2 0.1 2.0 1 1 1 2 2 2 1 WD40-like domain NEMP PF10225.9 KII70385.1 - 1.1e-14 54.7 0.2 1.5e-14 54.3 0.2 1.2 1 0 0 1 1 1 1 NEMP family DUF1451 PF07295.11 KII70385.1 - 0.011 15.8 2.7 0.012 15.6 1.7 1.6 1 1 0 1 1 1 0 Zinc-ribbon containing domain RRM_1 PF00076.22 KII70386.1 - 2.1e-11 43.5 0.0 4e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 KII70386.1 - 0.0022 17.9 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) RRM_5 PF13893.6 KII70386.1 - 0.023 14.3 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KII70386.1 - 0.037 14.1 0.1 0.081 13.0 0.1 1.5 1 0 0 1 1 1 0 RNA binding motif RNA_bind PF08675.11 KII70386.1 - 0.15 12.1 0.8 0.36 10.9 0.0 2.1 2 0 0 2 2 2 0 RNA binding domain Coprogen_oxidas PF01218.18 KII70387.1 - 2.2e-122 407.4 0.0 2.7e-122 407.1 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Mre11_DNA_bind PF04152.14 KII70388.1 - 9.7e-08 32.5 0.1 2.2e-07 31.3 0.1 1.6 1 1 0 1 1 1 1 Mre11 DNA-binding presumed domain DDE_1 PF03184.19 KII70390.1 - 1.1e-28 100.0 0.6 1.4e-28 99.7 0.6 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Homeodomain PF00046.29 KII70392.1 - 1.2e-18 66.7 1.9 3.1e-18 65.4 1.9 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KII70392.1 - 0.004 17.0 0.1 0.004 17.0 0.1 2.9 4 0 0 4 4 4 1 Homeobox KN domain MRP-63 PF14978.6 KII70392.1 - 0.036 14.7 0.1 0.091 13.4 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ribosome protein 63 RRF PF01765.19 KII70392.1 - 0.1 12.5 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 Ribosome recycling factor MAT1 PF06391.13 KII70393.1 - 8.4e-30 104.1 10.5 1.1e-29 103.7 10.5 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 KII70393.1 - 8.5e-07 28.8 5.6 1.5e-06 28.0 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF16 PF01519.16 KII70393.1 - 0.059 13.9 1.1 0.059 13.9 1.1 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 zf-RING_5 PF14634.6 KII70393.1 - 0.078 13.0 5.4 0.14 12.1 5.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 KII70393.1 - 0.38 10.8 4.1 0.77 9.8 4.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 KII70393.1 - 0.86 10.0 6.1 1.4 9.3 6.1 1.3 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 KII70393.1 - 1.3 9.0 6.5 2.7 7.9 6.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KII70393.1 - 1.7 8.9 6.3 0.35 11.0 2.5 1.8 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Spt4 PF06093.13 KII70393.1 - 2.4 8.3 0.0 2.4 8.3 0.0 2.5 2 1 0 2 2 2 0 Spt4/RpoE2 zinc finger Sec6 PF06046.13 KII70395.1 - 7.5e-53 179.8 2.4 7.5e-53 179.8 2.4 1.5 2 0 0 2 2 2 1 Exocyst complex component Sec6 STE PF02200.16 KII70395.1 - 0.016 15.6 0.1 6.5 7.2 0.0 3.0 2 0 0 2 2 2 0 STE like transcription factor DUF5339 PF17274.2 KII70395.1 - 0.027 15.3 0.4 0.027 15.3 0.4 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5339) CAP_N PF01213.19 KII70395.1 - 0.21 11.1 7.0 0.056 12.9 2.6 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal ApoLp-III PF07464.11 KII70395.1 - 0.5 10.5 12.7 0.84 9.7 8.3 3.5 3 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) SesA PF17107.5 KII70395.1 - 0.96 9.6 7.1 2.5 8.3 4.4 3.1 1 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases THOC7 PF05615.13 KII70395.1 - 1.1 9.6 7.5 0.84 9.9 3.3 3.0 1 1 1 2 2 2 0 Tho complex subunit 7 Tn7_Tnp_TnsA_C PF08721.11 KII70395.1 - 1.4 9.6 0.0 1.4 9.6 0.0 3.8 4 0 0 4 4 4 0 TnsA endonuclease C terminal Syntaxin_2 PF14523.6 KII70395.1 - 1.5 9.2 13.0 41 4.6 4.0 5.0 4 1 0 4 4 4 0 Syntaxin-like protein PTPlike_phytase PF14566.6 KII70395.1 - 2.2 8.4 4.9 64 3.6 4.9 2.4 1 1 0 1 1 1 0 Inositol hexakisphosphate Not3 PF04065.15 KII70395.1 - 6.3 6.2 17.0 60 3.0 15.5 3.1 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component EIF_2_alpha PF07541.12 KII70395.1 - 7.1 6.8 8.1 31 4.7 0.1 3.7 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit MCPsignal PF00015.21 KII70395.1 - 9.2 6.0 8.6 1.5 8.6 0.3 3.1 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Ku_PK_bind PF08785.11 KII70397.1 - 0.018 15.1 0.1 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Ku C terminal domain like Gag_p24 PF00607.20 KII70397.1 - 0.065 13.1 0.1 0.14 12.0 0.0 1.5 2 0 0 2 2 2 0 gag gene protein p24 (core nucleocapsid protein) DUF4897 PF16238.5 KII70397.1 - 0.1 12.4 0.8 0.17 11.7 0.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4897) zinc-ribbons_6 PF07191.12 KII70397.1 - 0.99 9.4 10.5 1.4 9.0 0.0 2.9 3 1 0 3 3 3 0 zinc-ribbons Retrotrans_gag PF03732.17 KII70398.1 - 2.1e-06 27.9 0.0 0.011 16.0 0.0 2.3 2 0 0 2 2 2 2 Retrotransposon gag protein zf-CCHC PF00098.23 KII70398.1 - 0.087 12.9 13.0 0.079 13.1 3.4 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII70398.1 - 0.32 10.8 10.9 2.6 7.8 1.8 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 KII70398.1 - 7.2 6.4 13.5 0.58 9.9 2.8 2.6 2 0 0 2 2 2 0 C2H2 zinc-finger DUF3677 PF12432.8 KII70400.1 - 7.8e-06 26.1 0.4 8.4e-05 22.8 0.0 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3677) DUF4971 PF16341.5 KII70403.1 - 0.088 12.6 0.5 0.19 11.6 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4971) TPR_MalT PF17874.1 KII70403.1 - 0.19 11.0 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region Arm PF00514.23 KII70404.1 - 2.2e-16 59.3 5.1 0.025 14.6 0.0 7.9 9 0 0 9 9 9 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KII70404.1 - 0.032 14.8 0.0 17 6.0 0.0 4.4 5 1 1 6 6 6 0 HEAT-like repeat DUF3385 PF11865.8 KII70404.1 - 0.71 9.8 4.8 0.48 10.3 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) DDE_1 PF03184.19 KII70405.1 - 0.052 13.2 0.0 0.074 12.7 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease RE_AspBHI_N PF18062.1 KII70405.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease AspBHI N-terminal TrbE PF11100.8 KII70406.1 - 0.034 14.4 0.5 1.2 9.5 0.1 2.3 2 0 0 2 2 2 0 Conjugal transfer protein TrbE Thioredoxin PF00085.20 KII70407.1 - 9.5e-13 48.0 0.1 2e-10 40.5 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 KII70407.1 - 0.0033 16.8 0.2 0.019 14.4 0.0 1.9 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family DUF4371 PF14291.6 KII70408.1 - 0.073 12.7 0.1 0.082 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) Mycobact_memb PF05423.13 KII70409.1 - 0.048 13.6 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 Mycobacterium membrane protein TMEM247 PF15444.6 KII70410.1 - 0.0099 15.9 0.9 0.011 15.8 0.9 1.2 1 0 0 1 1 1 1 Transmembrane protein 247 LtrA PF06772.11 KII70410.1 - 0.045 13.0 0.0 0.047 12.9 0.0 1.0 1 0 0 1 1 1 0 Bacterial low temperature requirement A protein (LtrA) Sortilin-Vps10 PF15902.5 KII70411.1 - 1.4e-10 40.6 0.3 2.3e-08 33.3 0.5 2.2 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII70411.1 - 2.2e-06 26.8 1.1 0.051 13.6 0.0 4.2 4 0 0 4 4 4 2 BNR/Asp-box repeat BNR_6 PF15899.5 KII70411.1 - 0.013 15.4 1.6 7.1 7.0 0.0 3.7 4 0 0 4 4 4 0 BNR-Asp box repeat DUF4221 PF13970.6 KII70411.1 - 0.016 14.8 0.5 0.031 13.8 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4221) Gal_Lectin PF02140.18 KII70412.1 - 2e-32 111.4 10.2 2.3e-17 63.2 1.7 2.2 2 0 0 2 2 2 2 Galactose binding lectin domain Collagen PF01391.18 KII70412.1 - 1.1e-29 102.0 110.3 1.5e-09 37.5 29.6 4.1 2 2 2 4 4 4 4 Collagen triple helix repeat (20 copies) Collagen PF01391.18 KII70413.1 - 7.1e-17 60.9 58.8 1.2e-09 37.8 29.5 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Gal_Lectin PF02140.18 KII70413.1 - 1.1e-15 57.8 2.4 1.8e-15 57.2 2.4 1.3 1 0 0 1 1 1 1 Galactose binding lectin domain Cornifin PF02389.15 KII70414.1 - 1.4e-14 54.5 52.7 2.5e-08 34.2 9.2 3.5 1 1 2 3 3 3 3 Cornifin (SPRR) family Fibrinogen_BP PF08017.11 KII70414.1 - 0.00044 18.8 26.8 0.00069 18.2 26.8 1.2 1 0 0 1 1 1 1 Fibrinogen binding protein Dynamin_N PF00350.23 KII70417.1 - 3.3e-11 43.5 0.1 6e-11 42.7 0.1 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KII70417.1 - 0.00035 20.6 0.2 0.00074 19.6 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 KII70417.1 - 0.0028 17.0 0.1 0.0045 16.3 0.1 1.3 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 KII70417.1 - 0.037 13.1 0.2 0.058 12.5 0.2 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 KII70417.1 - 0.12 12.9 0.3 0.27 11.7 0.1 1.6 1 1 1 2 2 2 0 ABC transporter ADAM_CR PF08516.12 KII70418.1 - 5e-09 36.6 6.5 5e-09 36.6 6.5 3.4 3 1 0 3 3 3 1 ADAM cysteine-rich LSM PF01423.22 KII70419.1 - 2.6e-16 59.1 0.1 3.6e-16 58.6 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KII70419.1 - 0.016 15.3 0.0 0.042 14.0 0.0 1.7 2 0 0 2 2 2 0 Ataxin 2 SM domain DUF4604 PF15377.6 KII70420.1 - 0.0083 16.6 13.8 0.46 10.9 11.3 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4604) AP3D1 PF06375.11 KII70420.1 - 0.0084 16.4 8.1 0.0087 16.3 8.1 1.0 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 2-oxoacid_dh PF00198.23 KII70421.1 - 5.4e-76 255.1 0.0 7.2e-76 254.7 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KII70421.1 - 5.6e-16 58.1 0.0 1.7e-15 56.6 0.0 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 KII70421.1 - 1.5e-14 54.1 0.0 2.8e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 KII70421.1 - 0.06 13.2 0.0 0.34 10.8 0.0 2.1 2 0 0 2 2 2 0 Biotin-lipoyl like HCNGP PF07818.13 KII70424.1 - 6e-17 62.1 0.1 9.6e-17 61.4 0.1 1.2 1 0 0 1 1 1 1 HCNGP-like protein DUF1447 PF07288.11 KII70424.1 - 0.064 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1447) Condensin2nSMC PF12422.8 KII70425.1 - 0.043 14.0 2.5 0.07 13.3 0.1 2.6 3 0 0 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit DUF1870 PF08965.10 KII70428.1 - 0.1 12.6 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) MatP_C PF17414.2 KII70428.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 MatP C-terminal ribbon-helix-helix domain RVP PF00077.20 KII70429.1 - 0.0093 16.3 0.0 0.038 14.3 0.0 2.0 2 1 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII70429.1 - 0.016 15.7 0.0 0.1 13.2 0.0 2.3 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease AT_hook PF02178.19 KII70429.1 - 6.5 7.0 8.0 0.58 10.2 1.4 2.4 2 0 0 2 2 2 0 AT hook motif IL17R_fnIII_D1 PF16556.5 KII70430.1 - 0.00036 20.2 0.6 0.00047 19.8 0.4 1.3 1 1 0 1 1 1 1 Interleukin-17 receptor, fibronectin-III-like domain 1 HTH_Tnp_Tc5 PF03221.16 KII70431.1 - 1.1e-05 25.4 0.0 1.8e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Baculo_11_kDa PF06143.11 KII70432.1 - 0.11 12.1 1.1 0.16 11.6 1.1 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family PetM PF08041.11 KII70432.1 - 0.12 12.0 3.1 0.18 11.4 3.1 1.3 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 ODV-E18 PF10717.9 KII70432.1 - 0.13 12.1 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 rve PF00665.26 KII70434.1 - 3.5e-21 75.6 0.0 7.9e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70434.1 - 1.1e-19 70.3 0.3 5.3e-19 68.1 0.5 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain DDE_Tnp_IS240 PF13610.6 KII70434.1 - 0.0032 17.7 0.2 0.027 14.7 0.0 2.3 2 0 0 2 2 2 1 DDE domain zf-H2C2 PF09337.10 KII70434.1 - 0.04 14.2 1.4 0.069 13.4 0.0 2.2 3 0 0 3 3 3 0 H2C2 zinc finger rve_3 PF13683.6 KII70434.1 - 0.045 13.5 0.0 0.16 11.8 0.0 2.0 1 0 0 1 1 1 0 Integrase core domain MLVIN_C PF18697.1 KII70434.1 - 0.045 13.8 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain UPF0640 PF15114.6 KII70435.1 - 0.082 12.7 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0640 CcmH PF03918.14 KII70435.1 - 0.19 11.0 0.6 0.26 10.6 0.5 1.4 1 1 0 1 1 1 0 Cytochrome C biogenesis protein Protocadherin PF08374.11 KII70438.1 - 0.00055 20.0 0.0 0.00066 19.7 0.0 1.1 1 0 0 1 1 1 1 Protocadherin DUF4834 PF16118.5 KII70438.1 - 0.016 16.1 0.0 0.027 15.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF1673 PF07895.11 KII70441.1 - 0.015 15.0 0.0 0.017 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) MLANA PF14991.6 KII70441.1 - 0.074 13.3 0.1 0.12 12.7 0.1 1.4 1 1 0 1 1 1 0 Protein melan-A SKG6 PF08693.10 KII70441.1 - 0.26 10.7 4.4 0.45 10.0 4.4 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Homeobox_KN PF05920.11 KII70443.1 - 4.9e-12 45.6 0.5 1e-11 44.5 0.5 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KII70443.1 - 1e-08 34.9 2.8 2e-08 34.0 2.8 1.5 1 0 0 1 1 1 1 Homeodomain YdaS_antitoxin PF15943.5 KII70443.1 - 0.0076 16.1 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT BMP2K_C PF15282.6 KII70443.1 - 0.014 15.3 0.7 0.017 15.0 0.7 1.1 1 0 0 1 1 1 0 BMP-2-inducible protein kinase C-terminus Homez PF11569.8 KII70443.1 - 0.063 12.8 0.3 0.22 11.0 0.1 2.0 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez SOUL PF04832.12 KII70444.1 - 1.2e-42 146.0 0.2 1.3e-42 145.8 0.2 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein HTH_Tnp_Tc3_2 PF01498.18 KII70445.1 - 0.027 14.7 0.1 0.061 13.6 0.1 1.5 2 0 0 2 2 2 0 Transposase Arg_repressor PF01316.21 KII70445.1 - 0.029 14.1 1.1 0.043 13.6 1.1 1.2 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Myb_DNA-binding PF00249.31 KII70446.1 - 2.9e-42 142.6 10.6 1.2e-14 54.2 0.1 3.7 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII70446.1 - 3.5e-33 113.6 6.7 4.3e-14 52.5 0.0 3.3 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KII70446.1 - 0.0018 18.1 0.7 0.15 11.9 0.0 3.2 3 1 1 4 4 4 1 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 KII70446.1 - 0.0039 17.6 9.0 0.56 10.6 0.9 3.6 3 1 0 3 3 3 2 Myb/SANT-like DNA-binding domain DUF3829 PF12889.7 KII70446.1 - 0.022 14.3 0.3 0.037 13.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) MULE PF10551.9 KII70448.1 - 1.3e-15 57.6 0.0 3.2e-15 56.3 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.16 KII70448.1 - 8.7e-11 41.8 3.8 1.6e-10 41.0 2.7 1.9 2 0 0 2 2 2 1 FLYWCH zinc finger domain G-patch PF01585.23 KII70449.1 - 1.7e-15 56.6 2.3 2.5e-15 56.1 0.8 2.0 2 0 0 2 2 2 1 G-patch domain Ank_2 PF12796.7 KII70449.1 - 6.8e-05 23.4 0.0 0.00013 22.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KII70449.1 - 0.00054 20.2 0.0 0.0021 18.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 KII70449.1 - 0.0014 19.2 0.0 0.11 13.1 0.0 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) G-patch_2 PF12656.7 KII70449.1 - 0.002 18.2 0.1 0.0059 16.7 0.1 1.8 1 0 0 1 1 1 1 G-patch domain Ank PF00023.30 KII70449.1 - 0.033 14.6 0.0 0.067 13.7 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeat Sortilin_C PF15901.5 KII70451.1 - 1.6e-08 35.1 0.1 2.8e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII70451.1 - 4.8e-07 28.9 0.3 7.2e-07 28.4 0.3 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, PSII_BNR PF14870.6 KII70451.1 - 0.012 14.9 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 BNR PF02012.20 KII70451.1 - 0.032 14.2 11.9 1.1 9.5 0.1 5.0 5 0 0 5 5 5 0 BNR/Asp-box repeat Annexin PF00191.20 KII70452.1 - 1.2e-06 28.5 1.2 0.012 15.6 0.2 2.7 2 0 0 2 2 2 2 Annexin CdiA_C_tRNase PF18664.1 KII70452.1 - 0.12 12.5 0.3 3.7 7.8 0.1 2.5 2 0 0 2 2 2 0 CdiA C-terminal tRNase domain TMEM154 PF15102.6 KII70453.1 - 0.0013 18.7 0.2 0.0017 18.3 0.2 1.3 1 0 0 1 1 1 1 TMEM154 protein family RIFIN PF02009.16 KII70453.1 - 0.0015 18.5 0.1 0.0016 18.4 0.1 1.1 1 0 0 1 1 1 1 Rifin Protocadherin PF08374.11 KII70453.1 - 0.02 14.9 0.2 0.025 14.6 0.2 1.1 1 0 0 1 1 1 0 Protocadherin DUF4448 PF14610.6 KII70453.1 - 0.023 14.5 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4690 PF15756.5 KII70453.1 - 0.027 15.1 0.2 0.042 14.5 0.2 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage Col_cuticle_N PF01484.17 KII70453.1 - 0.029 14.4 2.9 0.078 13.1 2.9 1.7 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Orf78 PF06024.12 KII70453.1 - 0.029 14.6 0.1 0.038 14.3 0.1 1.2 1 0 0 1 1 1 0 Orf78 (ac78) CortBP2 PF09727.9 KII70455.1 - 0.13 12.2 3.7 3.4 7.5 0.2 2.4 2 0 0 2 2 2 0 Cortactin-binding protein-2 ATP-synt_8 PF00895.20 KII70457.1 - 0.23 12.0 1.6 0.49 10.9 1.6 1.6 1 0 0 1 1 1 0 ATP synthase protein 8 DDE_3 PF13358.6 KII70458.1 - 6.4e-07 29.2 0.1 0.0003 20.6 0.1 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease TMEM154 PF15102.6 KII70459.1 - 0.00074 19.4 0.1 0.0011 18.8 0.1 1.3 1 0 0 1 1 1 1 TMEM154 protein family RIFIN PF02009.16 KII70459.1 - 0.0014 18.6 0.4 0.0017 18.4 0.4 1.1 1 0 0 1 1 1 1 Rifin DUF4366 PF14283.6 KII70459.1 - 0.0028 17.7 0.2 0.0039 17.2 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) DUF2207 PF09972.9 KII70459.1 - 0.0077 15.1 0.6 0.012 14.4 0.3 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) Orf78 PF06024.12 KII70459.1 - 0.012 15.9 0.1 0.019 15.2 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) LRRC37AB_C PF14914.6 KII70459.1 - 0.024 14.6 1.7 0.039 13.9 1.7 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain LIM_bind PF01803.16 KII70459.1 - 0.025 14.1 1.1 0.034 13.7 1.1 1.1 1 0 0 1 1 1 0 LIM-domain binding protein DUF1840 PF08895.11 KII70459.1 - 0.041 14.2 1.2 0.057 13.8 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) HCO3_cotransp PF00955.21 KII70459.1 - 0.065 12.1 1.3 0.074 11.9 1.3 1.0 1 0 0 1 1 1 0 HCO3- transporter family CSG2 PF16965.5 KII70459.1 - 0.082 11.8 0.3 0.096 11.6 0.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Consortin_C PF15281.6 KII70459.1 - 0.095 12.7 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Consortin C-terminus RPA43_OB PF17875.1 KII70459.1 - 0.13 12.9 3.0 0.21 12.2 3.0 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I MscS_TM PF12794.7 KII70459.1 - 0.17 10.7 2.8 0.23 10.3 2.8 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Zip PF02535.22 KII70459.1 - 0.18 11.0 0.1 0.24 10.5 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ETRAMP PF09716.10 KII70459.1 - 0.23 11.5 1.1 0.51 10.4 0.9 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Connexin PF00029.19 KII70459.1 - 0.29 10.9 3.6 0.2 11.4 2.8 1.2 1 1 0 1 1 1 0 Connexin Vma12 PF11712.8 KII70459.1 - 0.42 10.7 6.0 0.49 10.5 5.2 1.3 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase UPF0258 PF06789.12 KII70459.1 - 0.44 10.7 5.2 1.2 9.3 5.2 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0258) DNA_pol_phi PF04931.13 KII70459.1 - 4.5 5.2 13.5 5.8 4.9 13.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Ldl_recept_a PF00057.18 KII70460.1 - 3e-29 100.9 47.0 2.2e-11 43.8 11.4 3.0 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII70461.1 - 2e-21 75.9 44.7 9.9e-12 44.9 12.6 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A ADAM_CR PF08516.12 KII70461.1 - 0.029 14.8 2.4 0.029 14.8 2.4 3.1 1 1 2 3 3 3 0 ADAM cysteine-rich tRNA_bind_3 PF17176.4 KII70463.1 - 0.062 13.6 0.0 0.079 13.3 0.0 1.2 1 0 0 1 1 1 0 tRNA-binding domain MULE PF10551.9 KII70464.1 - 3.8e-11 43.3 0.1 1e-10 41.9 0.1 1.8 2 0 0 2 2 2 1 MULE transposase domain RT_RNaseH_2 PF17919.1 KII70465.1 - 2.7e-31 107.5 0.0 6.2e-31 106.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII70465.1 - 1.6e-28 99.1 0.0 3.6e-28 97.9 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70465.1 - 4.2e-28 98.4 0.0 7.2e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII70465.1 - 1.7e-22 79.8 0.1 7.6e-22 77.7 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70465.1 - 4.3e-15 55.6 0.9 1.6e-14 53.7 0.9 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII70465.1 - 0.00016 22.1 0.0 0.00038 21.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 KII70465.1 - 0.00048 19.8 0.0 0.0012 18.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII70465.1 - 0.0082 16.4 0.0 0.026 14.8 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.10 KII70465.1 - 0.021 15.0 0.1 0.079 13.2 0.1 2.1 1 0 0 1 1 1 0 H2C2 zinc finger Asp_protease_2 PF13650.6 KII70465.1 - 0.03 15.0 0.0 0.079 13.6 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease DUF5062 PF16691.5 KII70466.1 - 0.015 15.5 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5062) POX PF07526.11 KII70467.1 - 0.063 13.8 0.0 0.081 13.5 0.0 1.2 1 0 0 1 1 1 0 Associated with HOX DUF4094 PF13334.6 KII70468.1 - 0.00039 20.8 0.1 0.001 19.5 0.1 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4094) TMF_TATA_bd PF12325.8 KII70468.1 - 0.0047 17.1 1.4 0.023 14.9 0.1 2.0 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding FPP PF05911.11 KII70468.1 - 0.062 11.5 7.1 0.067 11.4 7.1 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF2553 PF10830.8 KII70468.1 - 0.068 14.0 1.8 0.13 13.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2553) Spc24 PF08286.11 KII70468.1 - 0.074 13.3 9.5 0.085 13.1 1.4 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 XhlA PF10779.9 KII70468.1 - 0.53 10.5 3.9 0.41 10.9 1.2 2.0 2 0 0 2 2 2 0 Haemolysin XhlA FlaC_arch PF05377.11 KII70468.1 - 0.6 10.5 4.3 0.2 12.1 0.9 1.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 KII70468.1 - 4 8.0 8.0 1.3 9.6 1.4 2.2 2 0 0 2 2 2 0 Cell division protein ZapB MIEAP PF16026.5 KII70469.1 - 0.031 14.5 0.4 0.031 14.5 0.4 2.8 3 1 0 3 3 3 0 Mitochondria-eating protein Allexi_40kDa PF05549.11 KII70469.1 - 1.7 8.1 9.5 2 7.9 0.1 3.1 3 0 0 3 3 3 0 Allexivirus 40kDa protein RPN6_N PF18055.1 KII70470.1 - 0.029 14.7 1.1 0.063 13.6 0.2 2.0 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain RTP1_C1 PF10363.9 KII70470.1 - 0.036 14.2 0.7 5.2 7.3 0.0 2.7 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF4745 PF15923.5 KII70470.1 - 0.13 12.3 0.7 0.44 10.5 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4745) Importin_rep_2 PF18786.1 KII70471.1 - 0.013 15.3 0.1 0.058 13.2 0.1 2.1 1 1 1 2 2 2 0 Importin 13 repeat IBN_N PF03810.19 KII70472.1 - 0.016 15.1 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Importin-beta N-terminal domain Creatinase_N PF01321.18 KII70473.1 - 0.16 12.7 0.0 0.3 11.7 0.0 1.7 1 1 0 1 1 1 0 Creatinase/Prolidase N-terminal domain Sulfotransfer_1 PF00685.27 KII70474.1 - 0.022 14.2 0.0 0.025 14.1 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain CheR PF01739.18 KII70474.1 - 0.16 11.4 3.5 4.3 6.8 0.4 2.0 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain RRM_3 PF08777.11 KII70477.1 - 1.3e-07 31.6 6.0 1.8e-07 31.1 0.2 2.9 2 1 0 3 3 3 1 RNA binding motif La PF05383.17 KII70477.1 - 0.0024 17.9 0.3 0.029 14.4 0.0 2.4 2 0 0 2 2 2 1 La domain RRM_1 PF00076.22 KII70477.1 - 0.014 15.2 0.1 4.8 7.1 0.0 3.4 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7TMR-HDED PF07697.11 KII70477.1 - 0.021 15.0 0.6 0.29 11.2 0.6 2.1 1 1 0 1 1 1 0 7TM-HD extracellular DUF3425 PF11905.8 KII70477.1 - 0.033 14.2 0.1 0.1 12.6 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3425) DUF4831 PF16115.5 KII70477.1 - 0.049 12.7 0.9 0.07 12.2 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4831) DUF4154 PF13689.6 KII70477.1 - 0.072 13.3 0.1 1.2 9.4 0.0 2.2 2 0 0 2 2 2 0 YfiR/HmsC-like DUF16 PF01519.16 KII70477.1 - 0.082 13.4 0.2 0.082 13.4 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 Sugar_tr PF00083.24 KII70478.1 - 2.1e-24 86.2 18.5 2e-19 69.8 5.6 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KII70478.1 - 1.9e-16 60.0 15.9 1.9e-16 60.0 15.9 1.6 1 1 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 KII70478.1 - 5.6e-05 21.9 7.9 0.00027 19.6 1.2 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein DUF4044 PF13253.6 KII70478.1 - 0.016 14.7 0.8 0.065 12.8 0.8 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) SID-1_RNA_chan PF13965.6 KII70478.1 - 0.071 11.5 0.8 0.13 10.7 0.8 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SNAP PF14938.6 KII70479.1 - 2.3e-06 27.3 0.8 3.3e-06 26.7 0.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RVT_1 PF00078.27 KII70484.1 - 3.5e-28 98.7 0.1 5e-28 98.1 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 KII70484.1 - 0.03 15.0 0.0 0.058 14.0 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease DUF4208 PF13907.6 KII70484.1 - 0.064 13.7 0.2 0.43 11.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) DUF349 PF03993.12 KII70484.1 - 0.079 13.3 0.3 0.22 11.9 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) gag-asp_proteas PF13975.6 KII70484.1 - 0.15 12.7 0.0 0.3 11.7 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease WDCP PF15390.6 KII70486.1 - 0.091 11.1 0.0 0.14 10.5 0.0 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DDE_3 PF13358.6 KII70490.1 - 3.5e-05 23.6 0.7 6.1e-05 22.8 0.7 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF4962 PF16332.5 KII70492.1 - 0.0014 17.3 5.0 0.0014 17.2 3.8 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4962) DUF5327 PF17261.2 KII70492.1 - 1.6 9.5 6.4 0.72 10.6 3.0 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5327) HTH_32 PF13565.6 KII70493.1 - 1.7e-05 25.3 0.0 2.3e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_33 PF13592.6 KII70493.1 - 0.052 13.2 0.0 0.094 12.4 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII70493.1 - 0.054 13.7 0.0 0.095 13.0 0.0 1.4 1 0 0 1 1 1 0 Transposase Rep_3 PF01051.21 KII70493.1 - 0.066 13.0 0.0 0.069 13.0 0.0 1.1 1 0 0 1 1 1 0 Initiator Replication protein DDE_3 PF13358.6 KII70494.1 - 3.7e-15 56.0 0.0 4.7e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease UDPGT PF00201.18 KII70494.1 - 0.022 13.6 0.0 0.026 13.4 0.0 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase DDE_3 PF13358.6 KII70496.1 - 0.0088 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease PAX PF00292.18 KII70496.1 - 0.024 14.6 0.5 0.044 13.7 0.5 1.4 1 0 0 1 1 1 0 'Paired box' domain HTH_32 PF13565.6 KII70496.1 - 0.038 14.6 0.1 0.11 13.1 0.0 1.8 3 0 0 3 3 3 0 Homeodomain-like domain KORA PF16509.5 KII70496.1 - 0.099 12.9 0.3 0.16 12.3 0.3 1.4 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor Snf7 PF03357.21 KII70497.1 - 3.4e-05 23.5 6.9 4e-05 23.3 6.9 1.1 1 0 0 1 1 1 1 Snf7 SurA_N PF09312.11 KII70497.1 - 0.18 11.9 2.3 0.79 9.8 0.5 2.4 1 1 2 3 3 3 0 SurA N-terminal domain RT_RNaseH PF17917.1 KII70498.1 - 2.1e-07 31.2 0.0 6.2e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70498.1 - 1.1e-06 28.3 0.0 1.9e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII70498.1 - 2.1e-06 27.7 0.3 0.00025 21.0 0.0 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase DDE_1 PF03184.19 KII70500.1 - 5.6e-24 84.7 0.3 2.4e-22 79.4 0.3 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII70500.1 - 0.022 14.5 0.3 0.048 13.4 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease Toprim_Crpt PF13342.6 KII70500.1 - 0.065 13.2 0.4 0.42 10.6 0.2 2.3 1 1 1 2 2 2 0 C-terminal repeat of topoisomerase HetR_C PF18460.1 KII70506.1 - 0.11 12.4 0.1 0.21 11.5 0.1 1.5 1 1 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain DUF3883 PF13020.6 KII70507.1 - 3.5e-14 52.6 0.1 6.4e-14 51.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) Serpin PF00079.20 KII70508.1 - 3.5e-38 131.9 0.1 6.2e-38 131.1 0.1 1.3 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Cnn_1N PF07989.11 KII70514.1 - 0.018 15.2 8.4 0.018 15.2 8.4 3.6 2 1 0 3 3 3 0 Centrosomin N-terminal motif 1 SOGA PF11365.8 KII70514.1 - 1.3 10.2 17.5 9 7.5 6.8 3.5 2 1 1 3 3 3 0 Protein SOGA zf-C2H2_aberr PF17017.5 KII70514.1 - 1.3 9.1 8.2 0.37 10.9 4.4 2.0 1 1 1 2 2 2 0 Aberrant zinc-finger CxC1 PF18802.1 KII70514.1 - 3.4 7.9 5.9 5.1 7.3 0.2 3.0 2 1 0 3 3 3 0 CxC1 like cysteine cluster associated with KDZ transposases Clathrin PF00637.20 KII70515.1 - 8.7e-06 25.7 0.1 1.5e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Region in Clathrin and VPS DDE_3 PF13358.6 KII70515.1 - 0.0018 18.0 0.0 0.023 14.4 0.0 2.4 1 1 1 2 2 2 1 DDE superfamily endonuclease TPR_7 PF13176.6 KII70515.1 - 0.045 13.8 0.1 5.7 7.2 0.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat AAA PF00004.29 KII70516.1 - 8.5e-11 42.4 0.0 1.1e-10 42.0 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KII70516.1 - 1.3e-05 24.9 0.0 2.5e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 KII70516.1 - 0.045 13.9 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA PF00004.29 KII70517.1 - 4.3e-08 33.6 0.0 6.7e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 KII70517.1 - 0.00052 19.8 0.0 0.00078 19.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 KII70517.1 - 0.00082 19.8 0.0 0.0011 19.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 KII70517.1 - 0.0027 17.3 0.0 0.0038 16.8 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 KII70517.1 - 0.0046 17.2 0.0 0.0062 16.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KII70517.1 - 0.0062 16.9 0.0 0.0078 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 KII70517.1 - 0.0066 17.0 0.0 0.01 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KII70517.1 - 0.013 16.0 0.0 0.074 13.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 KII70517.1 - 0.026 14.8 0.0 0.044 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KII70517.1 - 0.031 14.0 0.1 0.049 13.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KII70517.1 - 0.047 14.0 0.0 0.065 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KII70517.1 - 0.049 13.8 0.0 0.064 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.6 KII70517.1 - 0.057 13.6 0.0 0.073 13.2 0.0 1.1 1 0 0 1 1 1 0 Cytidylate kinase-like family DUF2075 PF09848.9 KII70517.1 - 0.067 12.4 0.0 0.09 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 KII70517.1 - 0.068 13.1 1.1 0.1 12.5 0.6 1.5 1 1 1 2 2 2 0 NTPase ADK PF00406.22 KII70517.1 - 0.073 13.2 0.0 0.17 12.0 0.0 1.6 2 0 0 2 2 2 0 Adenylate kinase AAA_29 PF13555.6 KII70517.1 - 0.084 12.6 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain MeaB PF03308.16 KII70517.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 KII70517.1 - 0.11 11.9 0.7 0.29 10.5 0.1 1.8 2 1 0 2 2 2 0 Chromatin associated protein KTI12 T2SSE PF00437.20 KII70517.1 - 0.13 11.3 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 KII70517.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Chlamy_scaf PF09675.10 KII70518.1 - 0.11 12.8 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) Sortilin-Vps10 PF15902.5 KII70520.1 - 0.0058 15.5 0.0 0.049 12.4 0.0 2.1 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII70520.1 - 0.19 11.8 0.4 0.19 11.8 0.4 3.1 3 0 0 3 3 3 0 BNR/Asp-box repeat DDE_3 PF13358.6 KII70521.1 - 0.0093 15.7 0.0 3.1 7.6 0.0 2.8 3 0 0 3 3 3 2 DDE superfamily endonuclease Glycos_transf_1 PF00534.20 KII70522.1 - 0.082 12.4 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferases group 1 rve PF00665.26 KII70524.1 - 9.5e-23 80.7 0.0 1.7e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII70524.1 - 0.00025 20.8 0.0 0.00059 19.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 KII70525.1 - 5e-36 123.2 0.0 1e-35 122.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII70525.1 - 2.1e-35 120.8 0.0 4.5e-35 119.7 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70525.1 - 8.1e-29 100.7 0.0 1.5e-28 99.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotran_gag_2 PF14223.6 KII70525.1 - 9.2e-06 25.4 0.4 0.0026 17.4 0.0 2.9 3 0 0 3 3 3 1 gag-polypeptide of LTR copia-type Asp_protease PF09668.10 KII70525.1 - 6.2e-05 22.8 0.0 0.00023 20.9 0.0 1.9 2 1 0 2 2 2 1 Aspartyl protease RVP PF00077.20 KII70525.1 - 0.0013 19.0 0.0 0.0028 17.9 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 KII70525.1 - 0.0053 16.8 1.2 0.0053 16.8 1.2 2.8 2 0 0 2 2 1 1 Zinc knuckle gag-asp_proteas PF13975.6 KII70525.1 - 0.024 15.2 0.0 0.069 13.7 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF5082 PF16888.5 KII70525.1 - 0.086 13.1 0.0 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) REC1 PF18501.1 KII70525.1 - 0.18 11.7 0.6 0.38 10.6 0.1 1.7 2 0 0 2 2 2 0 Alpha helical recognition lobe domain zf-CCHC_3 PF13917.6 KII70525.1 - 0.43 10.6 18.1 0.24 11.4 1.4 2.8 2 1 1 3 3 3 0 Zinc knuckle DDE_Tnp_IS1595 PF12762.7 KII70528.1 - 5.4e-08 33.0 0.5 5.4e-07 29.7 0.5 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain Nore1-SARAH PF16517.5 KII70529.1 - 0.48 10.4 2.9 1.1 9.3 1.2 2.3 1 1 1 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain MULE PF10551.9 KII70530.1 - 5e-12 46.1 1.5 3.6e-11 43.3 0.4 2.6 2 1 1 3 3 3 1 MULE transposase domain Nucleoporin_N PF08801.11 KII70530.1 - 0.03 13.1 0.3 0.5 9.0 0.0 2.0 1 1 1 2 2 2 0 Nup133 N terminal like Annexin PF00191.20 KII70533.1 - 6.4e-18 64.6 2.2 5e-07 29.7 0.0 4.3 4 0 0 4 4 4 3 Annexin AKAP95 PF04988.12 KII70533.1 - 0.025 14.8 1.4 0.93 9.7 0.2 2.4 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) RhoGAP PF00620.27 KII70535.1 - 3.3e-12 46.5 0.1 9.3e-12 45.0 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain RhoGAP PF00620.27 KII70536.1 - 1.9e-09 37.5 0.2 4e-09 36.5 0.2 1.5 1 0 0 1 1 1 1 RhoGAP domain START PF01852.19 KII70536.1 - 2.1e-06 27.3 0.0 4.8e-05 22.9 0.0 2.6 2 1 0 2 2 2 1 START domain 14-3-3 PF00244.20 KII70537.1 - 1.8e-64 217.3 0.1 2.1e-64 217.1 0.1 1.1 1 0 0 1 1 1 1 14-3-3 protein 14-3-3 PF00244.20 KII70538.1 - 1.6e-41 142.2 7.2 1.8e-41 142.0 7.2 1.0 1 0 0 1 1 1 1 14-3-3 protein DDE_Tnp_IS1595 PF12762.7 KII70539.1 - 6.7e-15 55.4 0.0 9.7e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain MF_alpha_N PF05436.11 KII70539.1 - 0.22 11.4 0.0 0.41 10.6 0.0 1.3 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus DDE_Tnp_IS1595 PF12762.7 KII70540.1 - 1.4e-16 60.9 0.0 1.9e-16 60.4 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII70540.1 - 0.013 15.2 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease Ntox10 PF15520.6 KII70540.1 - 0.1 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Novel toxin 10 Sedlin_N PF04628.13 KII70541.1 - 1.2e-20 74.0 2.1 1.4e-20 73.7 2.1 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 KII70541.1 - 0.0013 18.7 0.3 0.0022 17.9 0.3 1.6 1 1 0 1 1 1 1 Sybindin-like family LANC_like PF05147.13 KII70541.1 - 0.077 11.6 0.1 0.1 11.2 0.1 1.1 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein DUF508 PF04370.12 KII70541.1 - 0.11 12.2 0.0 0.17 11.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF508) DUF4336 PF14234.6 KII70542.1 - 0.00086 18.6 0.1 0.0011 18.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4336) DDE_3 PF13358.6 KII70542.1 - 0.0015 18.3 0.0 0.0029 17.4 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_DeoR PF08220.12 KII70542.1 - 0.11 12.3 0.5 0.16 11.7 0.5 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_24 PF13412.6 KII70542.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF507 PF04368.13 KII70544.1 - 0.099 12.6 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF507) NapB PF03892.14 KII70546.1 - 0.088 12.8 0.6 0.19 11.7 0.7 1.6 1 1 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) DUF2358 PF10184.9 KII70548.1 - 0.11 12.8 3.4 2 8.7 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2358) ABC_tran PF00005.27 KII70549.1 - 5.1e-47 159.8 3.6 9.5e-25 87.7 0.0 3.7 3 1 1 4 4 3 2 ABC transporter AAA_21 PF13304.6 KII70549.1 - 1.3e-17 64.6 6.4 7.5e-05 22.7 0.0 4.6 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KII70549.1 - 3.8e-12 46.1 3.7 0.00034 20.1 0.0 4.4 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KII70549.1 - 5.7e-07 29.6 0.6 0.0068 16.3 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KII70549.1 - 6.7e-07 28.9 0.1 0.002 17.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 KII70549.1 - 1.6e-06 28.4 0.0 0.013 15.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain ABC_tran_Xtn PF12848.7 KII70549.1 - 2.2e-06 27.6 7.5 2.2e-06 27.6 7.5 4.1 3 1 0 4 4 3 1 ABC transporter AAA_16 PF13191.6 KII70549.1 - 4.5e-06 27.1 0.0 0.12 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 KII70549.1 - 1.1e-05 25.9 4.1 0.059 13.8 0.0 3.5 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KII70549.1 - 1.6e-05 24.9 0.0 0.31 11.1 0.0 3.2 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 KII70549.1 - 1.7e-05 24.9 3.1 0.0078 16.3 0.0 3.6 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_24 PF13479.6 KII70549.1 - 2.6e-05 24.1 2.6 0.077 12.7 0.0 3.2 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 KII70549.1 - 2.7e-05 24.1 0.1 0.23 11.4 0.1 2.6 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.6 KII70549.1 - 4.3e-05 23.8 0.4 0.52 10.6 0.1 3.3 3 1 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 KII70549.1 - 4.4e-05 23.8 0.0 0.18 12.2 0.0 3.1 2 0 0 2 2 2 2 RNA helicase NB-ARC PF00931.22 KII70549.1 - 8.2e-05 21.9 0.1 0.071 12.3 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain AAA_7 PF12775.7 KII70549.1 - 0.00016 21.2 0.0 0.39 10.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 KII70549.1 - 0.00017 21.6 0.1 0.14 12.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) SRP54 PF00448.22 KII70549.1 - 0.00024 20.8 0.2 0.042 13.5 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_28 PF13521.6 KII70549.1 - 0.00034 20.9 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 KII70549.1 - 0.0004 20.2 0.0 0.82 9.4 0.0 3.2 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 KII70549.1 - 0.00063 20.0 0.1 2 8.6 0.0 2.9 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 KII70549.1 - 0.00089 18.9 0.1 0.7 9.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 KII70549.1 - 0.0014 19.2 4.9 0.54 10.8 0.0 3.7 5 0 0 5 5 2 2 AAA domain NTPase_1 PF03266.15 KII70549.1 - 0.0018 18.2 4.1 0.58 10.1 0.1 3.5 4 0 0 4 4 3 2 NTPase Rad17 PF03215.15 KII70549.1 - 0.0022 17.9 0.1 0.34 10.8 0.0 2.9 2 0 0 2 2 2 1 Rad17 P-loop domain cobW PF02492.19 KII70549.1 - 0.003 17.2 2.1 0.76 9.3 0.0 2.9 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 KII70549.1 - 0.0059 16.5 0.1 3.1 7.7 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ATP-synt_ab PF00006.25 KII70549.1 - 0.01 15.5 0.1 0.15 11.7 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase_2 PF01637.18 KII70549.1 - 0.011 15.7 7.6 0.83 9.5 0.0 3.6 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 KII70549.1 - 0.018 14.8 0.1 10 5.8 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein RuvB_N PF05496.12 KII70549.1 - 0.022 14.5 0.1 10 5.8 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain MeaB PF03308.16 KII70549.1 - 0.027 13.4 0.1 1.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 KII70549.1 - 0.032 14.2 0.1 8.8 6.3 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 KII70549.1 - 0.035 14.6 0.1 0.035 14.6 0.1 4.7 5 0 0 5 5 3 0 AAA domain PduV-EutP PF10662.9 KII70549.1 - 0.051 13.3 0.1 6 6.6 0.0 2.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.17 KII70549.1 - 0.061 13.4 0.0 0.061 13.4 0.0 4.3 4 1 1 5 5 5 0 Helicase HerA, central domain CLP1_P PF16575.5 KII70549.1 - 0.079 12.7 0.3 4.2 7.1 0.0 3.0 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_19 PF13245.6 KII70549.1 - 0.33 11.3 2.6 13 6.1 0.0 3.0 4 0 0 4 4 2 0 AAA domain TGT PF01702.18 KII70550.1 - 4.6e-67 226.6 0.4 5.2e-67 226.5 0.4 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase zf-C2H2_12 PF18658.1 KII70550.1 - 0.1 12.2 0.1 0.1 12.2 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger C2H2-type TGT PF01702.18 KII70551.1 - 1.6e-48 165.7 0.0 1.8e-48 165.5 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase PLAC8 PF04749.17 KII70554.1 - 3.4e-17 63.2 7.9 4.2e-17 63.0 7.9 1.1 1 0 0 1 1 1 1 PLAC8 family DUF4218 PF13960.6 KII70554.1 - 0.0034 17.0 1.2 0.0048 16.5 0.3 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4218) Leg1 PF05612.12 KII70555.1 - 0.04 13.1 0.5 0.041 13.0 0.5 1.2 1 0 0 1 1 1 0 Leg1 SnoaL_2 PF12680.7 KII70556.1 - 7e-17 61.9 0.0 8.5e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.20 KII70556.1 - 9.5e-08 32.6 0.0 1.4e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL PF07366.12 KII70556.1 - 1.1e-07 31.7 0.0 1.5e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase LEH PF07858.12 KII70556.1 - 0.0066 16.6 0.0 0.0082 16.2 0.0 1.2 1 1 0 1 1 1 1 Limonene-1,2-epoxide hydrolase catalytic domain SnoaL_4 PF13577.6 KII70556.1 - 0.049 13.8 0.0 0.071 13.2 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain DUF4440 PF14534.6 KII70556.1 - 0.058 13.8 0.0 0.07 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Porin_1 PF00267.21 KII70557.1 - 2.4e-85 287.0 15.2 2.7e-85 286.8 15.2 1.0 1 0 0 1 1 1 1 Gram-negative porin Channel_Tsx PF03502.13 KII70557.1 - 0.014 15.2 11.6 0.57 9.9 1.2 2.7 1 1 2 3 3 3 0 Nucleoside-specific channel-forming protein, Tsx Glyco_hydro_1 PF00232.18 KII70558.1 - 1.7e-130 435.5 2.5 2e-130 435.3 2.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.18 KII70558.1 - 0.00033 20.2 0.1 0.00052 19.5 0.1 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PTS_EIIC PF02378.18 KII70559.1 - 1.1e-18 67.3 29.2 1.1e-18 67.3 29.2 2.1 1 1 1 2 2 2 1 Phosphotransferase system, EIIC Staygreen PF12638.7 KII70561.1 - 0.0078 16.0 0.3 0.0097 15.7 0.3 1.1 1 0 0 1 1 1 1 Staygreen protein DUF3687 PF12459.8 KII70564.1 - 0.064 12.8 2.7 0.15 11.6 2.7 1.6 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein DUF4969 PF16339.5 KII70567.1 - 0.022 15.1 4.5 0.088 13.2 0.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4969) Phage_connect_1 PF05135.13 KII70567.1 - 0.024 15.1 1.2 0.033 14.7 1.2 1.3 1 1 0 1 1 1 0 Phage gp6-like head-tail connector protein rve_3 PF13683.6 KII70570.1 - 4.3e-06 26.4 0.0 6.5e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 KII70570.1 - 0.00018 21.7 0.0 0.00028 21.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70571.1 - 2.8e-09 37.0 0.1 4e-09 36.4 0.1 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII70571.1 - 0.068 13.4 0.5 0.11 12.7 0.5 1.3 1 0 0 1 1 1 0 H2C2 zinc finger Asp_protease_2 PF13650.6 KII70572.1 - 6.4e-08 33.1 0.0 8.6e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII70572.1 - 3.4e-06 27.5 0.0 4.6e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII70572.1 - 0.18 12.1 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF1569 PF07606.11 KII70573.1 - 0.0056 16.7 0.2 0.011 15.7 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1569) IZUMO PF15005.6 KII70573.1 - 0.13 12.8 0.4 0.13 12.8 0.4 1.5 1 1 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Glucan_synthase PF02364.15 KII70574.1 - 0.0089 14.2 3.9 0.051 11.7 0.9 2.0 2 0 0 2 2 2 2 1,3-beta-glucan synthase component Kazal_1 PF00050.21 KII70575.1 - 0.72 9.9 4.7 10 6.2 0.1 2.5 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain Snf7 PF03357.21 KII70578.1 - 1.7e-24 86.3 13.6 2e-24 86.1 13.6 1.1 1 0 0 1 1 1 1 Snf7 DUF1722 PF08349.11 KII70578.1 - 0.033 14.5 2.5 0.33 11.2 1.5 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1722) FapA PF03961.13 KII70578.1 - 0.13 10.8 8.2 0.19 10.3 0.1 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A FAP206 PF12018.8 KII70578.1 - 0.22 11.0 7.8 0.98 8.9 7.8 1.9 1 1 0 1 1 1 0 Domain of unknown function PSD2 PF07624.11 KII70578.1 - 0.28 11.0 1.8 0.98 9.2 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1585) DUF4936 PF16290.5 KII70578.1 - 0.31 11.8 2.7 12 6.7 0.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4936) DUF4298 PF14131.6 KII70578.1 - 0.6 10.1 10.7 1.6 8.7 0.4 3.4 2 2 1 3 3 3 0 Domain of unknown function (DUF4298) DUF29 PF01724.16 KII70578.1 - 0.61 10.3 13.9 1.5 9.1 1.5 3.1 1 1 1 3 3 3 0 Domain of unknown function DUF29 DUF1451 PF07295.11 KII70578.1 - 1.8 8.6 13.0 0.24 11.5 2.7 2.9 1 1 1 3 3 3 0 Zinc-ribbon containing domain LZ3wCH PF18517.1 KII70578.1 - 2.4 8.3 5.8 1.5 8.9 0.1 3.5 3 1 0 3 3 3 0 Leucine zipper with capping helix domain DASH_Dam1 PF08653.10 KII70578.1 - 4 7.3 11.2 15 5.4 0.3 3.8 4 0 0 4 4 4 0 DASH complex subunit Dam1 DUF883 PF05957.13 KII70578.1 - 9.5 6.9 8.9 15 6.2 2.9 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4256 PF14066.6 KII70583.1 - 0.18 11.5 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4256) KH_6 PF15985.5 KII70584.1 - 3.5e-05 24.1 0.0 8.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 KII70584.1 - 0.029 14.3 0.2 0.16 11.9 0.1 2.1 2 0 0 2 2 2 0 Exosome complex exonuclease Rrp40 N-terminal domain S1 PF00575.23 KII70584.1 - 0.062 13.7 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 S1 RNA binding domain SART-1 PF03343.13 KII70586.1 - 5.8e-15 54.9 6.1 5.8e-15 54.9 6.1 2.2 1 1 1 2 2 2 1 SART-1 family TMEM214 PF10151.9 KII70586.1 - 8.5 4.7 13.5 10 4.4 13.5 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Ank_5 PF13857.6 KII70587.1 - 1.5e-16 60.2 0.3 5.2e-08 33.0 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KII70587.1 - 1.8e-15 56.6 0.3 2.2e-06 27.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KII70587.1 - 4.3e-15 55.9 0.0 4.6e-06 27.1 0.0 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KII70587.1 - 1.2e-14 54.6 0.0 7.2e-14 52.1 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KII70587.1 - 1e-12 47.0 0.1 9.1e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat TRAP-delta PF05404.12 KII70587.1 - 0.14 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) Sec62 PF03839.16 KII70588.1 - 1.9e-38 132.1 5.5 2.1e-38 132.0 5.3 1.2 1 1 0 1 1 1 1 Translocation protein Sec62 DUF2207 PF09972.9 KII70588.1 - 0.066 12.0 0.5 0.081 11.7 0.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DNA_pol3_delta2 PF13177.6 KII70589.1 - 3.5e-08 33.4 0.4 4e-08 33.2 0.4 1.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 KII70589.1 - 0.061 13.7 0.6 0.15 12.5 0.6 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KII70589.1 - 0.08 13.2 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Solute_trans_a PF03619.16 KII70590.1 - 3e-35 122.1 19.2 3.6e-35 121.8 19.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Sas10_Utp3 PF04000.15 KII70590.1 - 0.1 13.2 0.5 0.18 12.4 0.5 1.5 1 0 0 1 1 1 0 Sas10/Utp3/C1D family S4 PF01479.25 KII70591.1 - 4.1e-10 39.2 0.0 7.8e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 KII70591.1 - 1.3e-05 26.0 0.6 2e-05 25.4 0.6 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain IBR PF01485.21 KII70593.1 - 9.6e-16 57.8 25.4 4.2e-11 42.9 9.9 3.9 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 KII70593.1 - 0.0022 17.8 11.3 0.0022 17.8 11.3 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII70593.1 - 0.011 16.1 11.2 0.011 16.1 11.2 3.7 3 0 0 3 3 3 0 Ring finger domain PSI_PsaJ PF01701.18 KII70593.1 - 5.3 7.7 5.3 14 6.3 1.3 2.4 2 0 0 2 2 2 0 Photosystem I reaction centre subunit IX / PsaJ Retrotran_gag_2 PF14223.6 KII70594.1 - 0.023 14.4 0.1 2.7 7.7 0.1 2.3 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type HATPase_c_3 PF13589.6 KII70595.1 - 4.1e-17 62.3 0.1 7.8e-12 45.2 0.0 2.2 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KII70595.1 - 0.0019 18.7 0.0 0.0046 17.4 0.0 1.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3829 PF12889.7 KII70596.1 - 0.002 17.7 3.3 0.37 10.2 0.7 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3829) SKA2 PF16740.5 KII70596.1 - 0.04 13.7 6.1 0.047 13.5 4.0 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 EXOSC1 PF10447.9 KII70596.1 - 0.045 14.4 0.1 0.11 13.1 0.1 1.7 1 0 0 1 1 1 0 Exosome component EXOSC1/CSL4 LpxI_N PF17930.1 KII70596.1 - 0.052 13.4 0.4 0.17 11.8 0.4 1.8 2 0 0 2 2 2 0 LpxI N-terminal domain tRNA_int_endo PF01974.17 KII70596.1 - 0.079 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 tRNA intron endonuclease, catalytic C-terminal domain CENP-F_leu_zip PF10473.9 KII70596.1 - 0.09 12.8 16.6 0.24 11.4 16.6 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V_ATPase_I PF01496.19 KII70596.1 - 0.13 10.2 4.8 0.17 9.7 4.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 KII70596.1 - 0.21 11.6 8.4 0.053 13.6 2.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 KII70596.1 - 0.45 10.8 5.7 42 4.5 5.7 2.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.13 KII70596.1 - 0.52 10.0 5.7 0.62 9.8 4.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Uso1_p115_C PF04871.13 KII70596.1 - 1.7 9.0 9.7 11 6.5 4.6 2.7 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Syntaxin_2 PF14523.6 KII70596.1 - 2.4 8.6 11.3 1.1 9.7 5.5 2.9 1 1 0 2 2 2 0 Syntaxin-like protein Laminin_II PF06009.12 KII70596.1 - 2.7 8.0 9.4 14 5.7 6.4 2.4 1 1 1 2 2 2 0 Laminin Domain II Prefoldin_2 PF01920.20 KII70596.1 - 5 7.1 11.9 7.7 6.5 0.8 3.0 1 1 1 2 2 2 0 Prefoldin subunit Sec20 PF03908.13 KII70596.1 - 5.8 6.9 6.5 35 4.4 0.2 3.4 2 1 1 3 3 3 0 Sec20 CENP-Q PF13094.6 KII70596.1 - 6.7 6.9 13.1 2.4e+02 1.9 13.1 2.2 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit XhlA PF10779.9 KII70596.1 - 7.3 6.9 7.4 7.6 6.8 2.1 2.7 2 0 0 2 2 2 0 Haemolysin XhlA GIIM PF08388.11 KII70597.1 - 0.072 13.1 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 Group II intron, maturase-specific domain DUF4007 PF13182.6 KII70599.1 - 1.7e-70 237.4 0.0 3.8e-70 236.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4007) IstB_IS21 PF01695.17 KII70599.1 - 0.00012 21.9 0.0 0.00047 19.9 0.0 2.0 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 KII70599.1 - 0.014 15.8 0.0 0.19 12.1 0.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain AAA_29 PF13555.6 KII70599.1 - 0.052 13.3 0.0 0.21 11.4 0.0 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain OmpH PF03938.14 KII70599.1 - 0.073 13.4 1.8 2 8.8 0.1 3.6 4 0 0 4 4 4 0 Outer membrane protein (OmpH-like) AAA_22 PF13401.6 KII70599.1 - 0.11 12.8 0.0 0.79 10.0 0.0 2.5 2 1 0 2 2 2 0 AAA domain MoaF PF10703.9 KII70600.1 - 0.19 11.7 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 MoaF N-terminal domain SNAP PF14938.6 KII70601.1 - 0.00069 19.1 0.3 0.00084 18.8 0.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII70601.1 - 0.0046 17.1 3.5 0.17 12.2 0.1 2.7 2 1 2 4 4 4 3 Tetratricopeptide repeat SNAP PF14938.6 KII70603.1 - 0.0031 17.0 1.5 0.0055 16.2 1.5 1.5 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Lipoprotein_19 PF13617.6 KII70603.1 - 0.018 14.8 3.1 0.018 14.8 3.1 2.9 3 0 0 3 3 3 0 YnbE-like lipoprotein OSTMP1 PF09777.9 KII70603.1 - 0.05 13.0 4.1 0.094 12.1 4.1 1.4 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor DUF445 PF04286.12 KII70603.1 - 0.13 12.1 13.4 0.21 11.3 13.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) ATAD4 PF15321.6 KII70603.1 - 0.44 11.9 11.5 1.6 10.2 4.1 3.2 3 1 0 3 3 3 0 ATPase family AAA domain containing 4 Ubiquitin_3 PF14836.6 KII70603.1 - 0.47 10.5 3.3 0.45 10.5 1.4 2.0 2 0 0 2 2 2 0 Ubiquitin-like domain DDE_3 PF13358.6 KII70604.1 - 7.3e-19 68.0 0.0 8.7e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_6 PF13964.6 KII70605.1 - 1.8e-09 37.5 12.4 0.24 11.7 0.1 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 KII70605.1 - 1.3e-06 27.9 11.0 0.011 15.4 0.1 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 KII70605.1 - 4.4e-06 26.4 8.6 0.82 9.7 0.1 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 KII70605.1 - 2e-05 24.5 2.4 4.5 7.4 0.0 5.1 5 0 0 5 5 5 2 Galactose oxidase, central domain FBA_3 PF08268.12 KII70605.1 - 0.0004 20.3 0.6 0.16 11.9 0.4 2.4 2 0 0 2 2 2 2 F-box associated domain Kelch_3 PF13415.6 KII70605.1 - 0.28 11.5 5.3 12 6.4 0.0 4.4 5 0 0 5 5 5 0 Galactose oxidase, central domain CCDC53 PF10152.9 KII70609.1 - 0.075 13.4 0.9 0.11 12.9 0.9 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex FIN1 PF17300.2 KII70612.1 - 0.11 12.0 0.2 3.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Filaments in between nuclei protein-1 YwpF PF14183.6 KII70612.1 - 0.12 12.4 0.0 1.7 8.7 0.0 2.1 1 1 1 2 2 2 0 YwpF-like protein Hs1pro-1_C PF07014.12 KII70614.1 - 0.1 12.0 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Hs1pro-1 protein C-terminus CytochromB561_N PF09786.9 KII70616.1 - 0.0021 17.1 1.9 0.0023 17.0 1.9 1.0 1 0 0 1 1 1 1 Cytochrome B561, N terminal DUF4007 PF13182.6 KII70616.1 - 0.029 13.5 2.0 0.034 13.3 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4007) Lysis_col PF02402.16 KII70616.1 - 0.28 10.9 0.2 0.28 10.9 0.2 1.6 2 0 0 2 2 2 0 Lysis protein RT_RNaseH PF17917.1 KII70617.1 - 2.5e-40 137.0 0.0 5.8e-40 135.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII70617.1 - 5.8e-36 122.5 0.0 1.5e-35 121.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70617.1 - 1.8e-30 106.1 0.1 3.8e-30 105.1 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII70617.1 - 9.3e-27 93.6 0.0 3.3e-26 91.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70617.1 - 2.2e-17 62.9 5.2 5.7e-17 61.6 2.5 2.8 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII70617.1 - 2.6e-06 27.9 0.0 6.3e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 KII70617.1 - 6.3e-06 26.0 0.5 1.3e-05 24.9 0.5 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII70617.1 - 2.3e-05 24.2 0.0 8.7e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.23 KII70617.1 - 0.00017 21.5 8.9 0.085 13.0 1.1 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-H2C2 PF09337.10 KII70617.1 - 0.0011 19.1 0.0 0.0082 16.3 0.0 2.5 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII70617.1 - 0.0027 17.4 0.0 0.0079 16.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII70617.1 - 0.017 15.2 0.0 0.051 13.7 0.0 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Asp_protease_2 PF13650.6 KII70617.1 - 0.023 15.4 0.0 0.054 14.1 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII70617.1 - 0.077 13.3 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_2 PF13696.6 KII70617.1 - 0.23 11.3 11.8 1.6 8.6 4.6 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII70617.1 - 0.31 10.8 6.8 1.6 8.5 0.7 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 KII70617.1 - 0.33 10.8 13.7 0.25 11.2 2.4 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 KII70617.1 - 0.44 10.5 13.5 57 3.8 13.5 2.7 1 1 0 1 1 1 0 Zinc knuckle Peptidase_C1 PF00112.23 KII70619.1 - 7.5e-66 222.3 0.9 1e-65 221.9 0.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII70619.1 - 1.4e-06 28.6 0.6 2.8e-06 27.7 0.6 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KII70619.1 - 6.7e-06 25.1 0.1 1.1e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase C1-like family EppA_BapA PF07268.11 KII70619.1 - 0.045 13.7 0.0 0.077 12.9 0.0 1.3 1 0 0 1 1 1 0 Exported protein precursor (EppA/BapA) Peptidase_C39_2 PF13529.6 KII70619.1 - 0.055 14.0 0.3 0.24 11.9 0.0 2.1 2 0 0 2 2 2 0 Peptidase_C39 like family DUF4233 PF14017.6 KII70620.1 - 0.27 11.6 3.6 0.68 10.3 3.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4233) zf-C2H2_12 PF18658.1 KII70621.1 - 0.0028 17.2 0.0 0.0039 16.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger C2H2-type zf-BED PF02892.15 KII70621.1 - 0.006 16.6 0.3 0.011 15.8 0.3 1.4 1 0 0 1 1 1 1 BED zinc finger zf-C2HE PF16278.5 KII70621.1 - 0.093 13.2 0.1 0.16 12.4 0.1 1.4 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger DDE_Tnp_IS1595 PF12762.7 KII70622.1 - 5.1e-08 33.1 0.3 3.8e-07 30.2 0.1 1.9 1 1 1 2 2 2 1 ISXO2-like transposase domain DDE_1 PF03184.19 KII70623.1 - 0.085 12.5 0.0 0.19 11.4 0.0 1.6 1 1 0 1 1 1 0 DDE superfamily endonuclease DUF2250 PF10007.9 KII70623.1 - 0.1 12.7 0.2 6.2 7.0 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) DUF3810 PF12725.7 KII70624.1 - 0.014 14.8 4.3 0.014 14.8 4.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) HTH_32 PF13565.6 KII70625.1 - 7.6e-10 39.3 0.0 2e-07 31.5 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 KII70625.1 - 4.5e-08 32.7 0.0 7.6e-07 28.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain DDE_3 PF13358.6 KII70625.1 - 3.5e-05 23.6 0.0 7.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease PAX PF00292.18 KII70625.1 - 0.0029 17.5 0.1 0.0057 16.6 0.1 1.4 1 0 0 1 1 1 1 'Paired box' domain TrmB PF01978.19 KII70625.1 - 0.003 17.4 0.1 0.0065 16.3 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.6 KII70625.1 - 0.0032 17.5 0.0 0.0087 16.2 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII70625.1 - 0.012 15.8 0.2 0.14 12.5 0.0 2.4 2 1 0 2 2 2 0 Transposase HTH_40 PF14493.6 KII70625.1 - 0.013 16.0 0.2 0.049 14.1 0.1 2.0 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 KII70625.1 - 0.024 14.1 0.0 0.068 12.6 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_33 PF13592.6 KII70625.1 - 0.027 14.1 0.0 0.056 13.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Rep_3 PF01051.21 KII70625.1 - 0.035 13.9 0.1 0.046 13.5 0.1 1.2 1 0 0 1 1 1 0 Initiator Replication protein Ntox50 PF15542.6 KII70625.1 - 0.05 14.4 5.7 20 6.1 5.7 2.9 1 1 0 1 1 1 0 Bacterial toxin 50 HTH_29 PF13551.6 KII70625.1 - 0.054 13.5 0.1 0.37 10.9 0.1 2.3 3 0 0 3 3 3 0 Winged helix-turn helix DUF4817 PF16087.5 KII70625.1 - 0.081 12.7 0.1 0.37 10.6 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) HTH_Tnp_1 PF01527.20 KII70625.1 - 0.086 13.2 0.1 0.17 12.2 0.1 1.5 1 0 0 1 1 1 0 Transposase DUF2207 PF09972.9 KII70627.1 - 3.6 6.2 6.3 4.1 6.0 6.3 1.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Srg PF02118.21 KII70628.1 - 0.00032 20.4 3.8 0.00032 20.4 3.8 1.3 1 1 0 1 1 1 1 Srg family chemoreceptor DUF4131 PF13567.6 KII70628.1 - 1.8 8.2 5.3 4.3 7.0 1.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF1365 PF07103.11 KII70631.1 - 0.0013 18.5 0.6 0.0019 17.9 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) FBA_2 PF07735.17 KII70631.1 - 0.052 13.7 0.4 0.68 10.1 0.4 2.8 2 1 0 2 2 2 0 F-box associated Ldl_recept_a PF00057.18 KII70633.1 - 5.4e-06 26.5 12.2 9.3e-06 25.8 12.2 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DSPc PF00782.20 KII70634.1 - 0.0002 21.2 0.0 0.00029 20.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KII70634.1 - 0.017 15.2 0.0 0.035 14.2 0.0 1.4 1 1 0 1 1 1 0 Inositol hexakisphosphate Glyco_transf_28 PF03033.20 KII70634.1 - 0.057 13.4 0.0 0.096 12.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Y_phosphatase PF00102.27 KII70634.1 - 0.064 12.8 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF4868 PF16162.5 KII70635.1 - 0.012 15.5 0.6 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4868) Ldl_recept_a PF00057.18 KII70637.1 - 4.8e-14 52.3 27.6 2.4e-07 30.9 13.1 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 KII70637.1 - 0.22 11.3 14.9 0.41 10.4 14.9 1.4 1 1 0 1 1 1 0 Glucosidase II beta subunit-like Ldl_recept_a PF00057.18 KII70638.1 - 2.1e-33 114.2 92.4 5.4e-11 42.5 11.9 5.9 6 0 0 6 6 6 5 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII70639.1 - 1.4e-08 34.8 33.2 0.00031 20.9 12.1 2.5 1 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII70640.1 - 3.6e-12 46.3 31.7 9.8e-07 28.9 11.3 2.9 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Pur_ac_phosph_N PF16656.5 KII70640.1 - 0.0096 16.5 0.1 0.016 15.8 0.1 1.4 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain GerE PF00196.19 KII70642.1 - 1.3e-12 47.0 0.3 2.1e-12 46.4 0.3 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_7 PF02796.15 KII70642.1 - 4.9e-05 23.3 0.1 8.8e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 KII70642.1 - 8.5e-05 22.2 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 KII70642.1 - 0.00017 21.2 0.1 0.00026 20.6 0.1 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_28 PF13518.6 KII70642.1 - 0.0036 17.4 0.0 0.0061 16.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 KII70642.1 - 0.0081 16.2 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_40 PF14493.6 KII70642.1 - 0.066 13.7 0.6 0.14 12.6 0.1 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain L_protein_N PF15518.6 KII70643.1 - 0.073 12.9 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 L protein N-terminus RT_RNaseH_2 PF17919.1 KII70644.1 - 3.4e-35 120.1 0.1 8.1e-35 118.9 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII70644.1 - 9.5e-25 86.9 0.1 2.2e-24 85.8 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70644.1 - 2.1e-19 69.9 0.0 5.7e-19 68.5 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII70644.1 - 4.1e-07 30.5 0.0 8.8e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII70644.1 - 2e-05 25.1 0.0 5e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII70644.1 - 0.0034 17.7 0.1 0.0083 16.4 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII70644.1 - 0.045 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.6 KII70644.1 - 0.11 12.2 3.7 0.31 10.8 3.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger MIIP PF15734.5 KII70647.1 - 0.0068 15.9 0.0 0.0077 15.8 0.0 1.1 1 0 0 1 1 1 1 Migration and invasion-inhibitory DDE_3 PF13358.6 KII70650.1 - 0.003 17.3 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease U6-snRNA_bdg PF10596.9 KII70654.1 - 0.0027 17.7 0.1 0.0033 17.4 0.1 1.1 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 Tox-HNH-EHHH PF15657.6 KII70655.1 - 0.13 12.6 2.6 0.41 11.0 2.6 1.9 1 1 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxins Carbam_trans_C PF16861.5 KII70656.1 - 0.08 12.5 0.2 0.25 10.9 0.1 1.6 1 1 0 2 2 2 0 Carbamoyltransferase C-terminus DDE_3 PF13358.6 KII70658.1 - 6e-18 65.0 0.0 8.5e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_hydro_18 PF00704.28 KII70658.1 - 0.093 12.4 0.0 0.099 12.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 DDE_1 PF03184.19 KII70659.1 - 3.2e-10 39.9 0.1 4.8e-10 39.4 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease BNR_2 PF13088.6 KII70659.1 - 0.15 11.3 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 BNR repeat-like domain DDE_Tnp_IS1595 PF12762.7 KII70660.1 - 2e-06 27.9 0.0 3.2e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain Ribosomal_60s PF00428.19 KII70662.1 - 1.1e-11 45.2 0.2 1.4e-11 44.8 0.2 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein TSP9 PF11493.8 KII70662.1 - 0.018 15.7 0.6 0.027 15.1 0.6 1.3 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 CAP_N PF01213.19 KII70664.1 - 1.2e-60 205.7 3.2 9.1e-60 202.8 3.2 2.1 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 KII70664.1 - 5.8e-36 123.5 14.3 8.8e-36 122.9 14.3 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Csm2_III-A PF03750.13 KII70664.1 - 0.024 15.5 0.2 0.079 13.8 0.0 2.0 2 0 0 2 2 2 0 Csm2 Type III-A Ndc1_Nup PF09531.10 KII70664.1 - 0.036 12.8 2.1 0.067 11.9 2.1 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PRC2_HTH_1 PF18118.1 KII70664.1 - 0.13 13.0 0.1 0.7 10.7 0.1 2.2 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Succ_DH_flav_C PF02910.20 KII70664.1 - 0.16 12.0 0.2 4.7 7.2 0.1 2.6 2 0 0 2 2 2 0 Fumarate reductase flavoprotein C-term TBCC PF07986.12 KII70664.1 - 2.2 8.0 10.0 0.78 9.5 4.0 2.2 1 1 1 2 2 2 0 Tubulin binding cofactor C HSP20 PF00011.21 KII70665.1 - 2e-16 60.0 0.3 5.2e-07 29.7 0.1 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family Ribosomal_L17 PF01196.19 KII70667.1 - 0.015 16.1 0.0 0.032 15.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L17 PrmA PF06325.13 KII70670.1 - 5.1e-11 42.5 0.3 7.6e-11 41.9 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KII70670.1 - 8e-11 42.5 0.1 2.7e-10 40.8 0.0 1.9 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII70670.1 - 2.6e-09 37.6 0.0 6.6e-09 36.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KII70670.1 - 8.5e-09 35.4 0.0 1.2e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII70670.1 - 2.1e-06 27.7 0.0 3.9e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KII70670.1 - 5.9e-06 25.9 0.2 8.9e-06 25.4 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 KII70670.1 - 6.5e-05 22.9 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 KII70670.1 - 0.00019 21.2 0.1 0.00028 20.7 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PRMT5 PF05185.16 KII70670.1 - 0.0023 17.8 0.0 0.0038 17.1 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase TehB PF03848.14 KII70670.1 - 0.0025 17.2 0.1 0.0054 16.2 0.1 1.7 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_9 PF08003.11 KII70670.1 - 0.0032 16.4 0.0 0.0042 16.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 KII70670.1 - 0.0095 16.7 0.0 0.017 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KII70670.1 - 0.01 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 KII70670.1 - 0.034 14.1 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Phage-A118_gp45 PF10653.9 KII70670.1 - 0.057 13.5 0.1 1.2 9.2 0.1 2.5 2 0 0 2 2 2 0 Protein gp45 of Bacteriophage A118 CMAS PF02353.20 KII70670.1 - 0.066 12.5 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 KII70670.1 - 0.078 14.0 0.0 0.21 12.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Transglut_C PF00927.22 KII70672.1 - 0.019 15.1 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain Ubie_methyltran PF01209.18 KII70674.1 - 2.9e-72 242.8 0.1 3.9e-72 242.4 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 KII70674.1 - 1.7e-19 70.2 0.0 7.4e-19 68.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KII70674.1 - 9.3e-19 67.9 0.0 4.3e-18 65.8 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII70674.1 - 1.1e-18 67.6 0.0 3.3e-18 66.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KII70674.1 - 1.2e-11 45.2 0.0 2.4e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII70674.1 - 2.2e-09 37.3 0.0 3.2e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KII70674.1 - 0.0063 16.1 0.0 1.8 8.1 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase small domain DREV PF05219.12 KII70674.1 - 0.0064 15.6 0.0 0.019 14.1 0.0 1.7 1 1 1 2 2 2 1 DREV methyltransferase DUF4376 PF14301.6 KII70674.1 - 0.0072 16.7 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4376) UPF0020 PF01170.18 KII70674.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Inhibitor_I78 PF11720.8 KII70674.1 - 0.021 14.9 0.0 6.8 6.8 0.0 2.8 3 0 0 3 3 3 0 Peptidase inhibitor I78 family Methyltransf_32 PF13679.6 KII70674.1 - 0.034 14.1 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 KII70674.1 - 0.064 12.9 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F MetW PF07021.12 KII70674.1 - 0.096 12.3 0.0 0.43 10.1 0.0 1.9 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW FCH PF00611.23 KII70674.1 - 0.18 12.1 0.2 0.54 10.6 0.0 1.8 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain DCB PF16213.5 KII70675.1 - 0.00079 19.1 2.2 0.00096 18.9 2.2 1.1 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 YWFCY PF14293.6 KII70677.1 - 1.7 9.0 5.9 1.2 9.5 3.9 1.9 1 1 1 2 2 2 0 YWFCY protein SAYSvFN PF10260.9 KII70678.1 - 2.7e-16 59.2 0.2 3.5e-16 58.9 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) TctB PF07331.11 KII70678.1 - 0.017 15.4 0.0 0.02 15.2 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family CPP1-like PF11833.8 KII70678.1 - 0.15 11.7 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like JSRP PF15312.6 KII70678.1 - 0.22 11.5 0.5 3.8 7.5 0.0 2.3 2 1 0 2 2 2 0 Junctional sarcoplasmic reticulum protein RRM_1 PF00076.22 KII70679.1 - 1.3e-17 63.4 0.0 1.6e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII70679.1 - 0.033 14.3 0.0 0.07 13.3 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif RuvB_N PF05496.12 KII70680.1 - 0.095 12.4 0.3 0.12 12.1 0.3 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain YebG PF07130.12 KII70682.1 - 0.88 9.5 8.5 9 6.2 0.2 3.0 1 1 2 3 3 3 0 YebG protein Ldl_recept_a PF00057.18 KII70683.1 - 3.1e-07 30.5 9.1 3.1e-07 30.5 9.1 2.9 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII70684.1 - 8e-15 55.6 8.5 1.5e-14 54.7 8.5 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII70684.1 - 2.6e-06 26.5 0.0 5.1e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, PRELI PF04707.14 KII70685.1 - 3.2e-05 23.8 0.3 4e-05 23.5 0.3 1.2 1 0 0 1 1 1 1 PRELI-like family Keratin_B2_2 PF13885.6 KII70686.1 - 2.6e-18 65.7 100.2 0.00014 21.8 20.2 4.4 1 1 3 4 4 4 4 Keratin, high sulfur B2 protein PMG PF05287.12 KII70686.1 - 3.9e-05 23.8 82.9 0.018 15.1 39.5 2.1 1 1 1 2 2 2 2 PMG protein DDE_3 PF13358.6 KII70687.1 - 1.9e-12 47.2 0.0 2.2e-05 24.2 0.0 2.4 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_3 PF13358.6 KII70689.1 - 0.001 18.8 0.0 0.0012 18.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3911 PF13050.6 KII70690.1 - 0.17 12.0 0.6 1.1 9.4 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3911) DDE_3 PF13358.6 KII70691.1 - 4.2e-13 49.3 0.0 8.4e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII70691.1 - 0.00012 22.6 0.0 0.00092 19.8 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain Arg_repressor PF01316.21 KII70691.1 - 0.0047 16.7 0.0 0.033 13.9 0.0 2.4 2 0 0 2 2 2 1 Arginine repressor, DNA binding domain HTH_ABP1_N PF18107.1 KII70691.1 - 0.0061 16.2 0.0 0.022 14.5 0.0 1.9 2 0 0 2 2 2 1 Fission yeast centromere protein N-terminal domain HTH_29 PF13551.6 KII70691.1 - 0.01 15.8 0.0 0.28 11.2 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn helix HTH_Tnp_4 PF13613.6 KII70691.1 - 0.014 15.1 0.0 3.8 7.3 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease HTH_23 PF13384.6 KII70691.1 - 0.045 13.6 0.0 7.9 6.4 0.0 2.5 2 0 0 2 2 2 0 Homeodomain-like domain PAX PF00292.18 KII70691.1 - 0.063 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 'Paired box' domain Aminoglyc_resit PF10706.9 KII70691.1 - 0.16 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Aminoglycoside-2''-adenylyltransferase Ank_2 PF12796.7 KII70693.1 - 5e-84 277.0 21.2 2.4e-16 60.1 0.1 8.8 3 1 7 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII70693.1 - 3.3e-73 241.2 20.5 2e-12 47.4 0.0 10.5 7 3 3 11 11 11 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 KII70693.1 - 9.9e-65 213.8 22.8 3.3e-07 30.5 0.0 15.1 4 2 11 15 15 15 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII70693.1 - 8.6e-62 197.8 25.5 8e-05 22.8 0.2 18.0 18 0 0 18 18 18 13 Ankyrin repeat Ank PF00023.30 KII70693.1 - 7.7e-57 187.4 29.1 0.0001 22.6 0.2 16.3 16 0 0 16 16 16 14 Ankyrin repeat Ion_trans PF00520.31 KII70693.1 - 3e-06 26.6 30.3 1.6e-05 24.3 30.7 2.0 1 1 1 2 2 2 1 Ion transport protein IBN_N PF03810.19 KII70695.1 - 0.028 14.3 1.3 0.2 11.6 0.2 2.4 2 1 0 2 2 2 0 Importin-beta N-terminal domain Glyco_transf_8 PF01501.20 KII70697.1 - 0.077 12.5 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 8 FAST_1 PF06743.15 KII70699.1 - 0.011 15.7 0.7 14 5.7 0.0 3.6 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 MULE PF10551.9 KII70700.1 - 2.6e-11 43.8 0.0 5.3e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Herpes_gE PF02480.16 KII70702.1 - 0.0026 16.6 0.0 0.0027 16.5 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E CRA PF06589.11 KII70704.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) zf-CCCH PF00642.24 KII70705.1 - 9.5e-06 25.4 5.2 1.7e-05 24.6 5.2 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 KII70705.1 - 3.5e-05 23.5 0.0 5.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 KII70705.1 - 2.2 8.5 8.2 0.43 10.7 4.6 1.8 2 0 0 2 2 2 0 Zinc finger domain Integrase_H2C2 PF17921.1 KII70706.1 - 4e-08 33.2 0.0 8e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII70706.1 - 0.015 15.5 0.0 0.038 14.2 0.0 1.7 1 0 0 1 1 1 0 H2C2 zinc finger GCHY-1 PF02649.14 KII70706.1 - 0.024 14.2 0.0 0.03 13.8 0.0 1.1 1 0 0 1 1 1 0 Type I GTP cyclohydrolase folE2 PDGF_N PF04692.13 KII70706.1 - 0.057 14.2 0.7 1.2 10.0 0.1 2.3 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region SF3A2 PF16835.5 KII70709.1 - 0.0071 16.7 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) ABC_sub_bind PF04392.12 KII70709.1 - 0.048 12.9 0.0 0.07 12.4 0.0 1.1 1 0 0 1 1 1 0 ABC transporter substrate binding protein WD40 PF00400.32 KII70710.1 - 3.1e-11 43.6 0.1 1.3e-07 32.1 0.1 2.6 3 0 0 3 3 3 2 WD domain, G-beta repeat DDE_Tnp_IS1595 PF12762.7 KII70711.1 - 7.9e-09 35.7 0.0 9.3e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain CLP1_P PF16575.5 KII70712.1 - 8.6e-09 35.5 0.0 1.8e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF4768 PF15989.5 KII70714.1 - 0.081 12.9 0.8 0.18 11.8 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4768) FragX_IP PF05994.11 KII70715.1 - 1.8e-157 525.8 19.6 3.1e-157 525.1 19.6 1.3 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family FragX_IP PF05994.11 KII70718.1 - 1.4e-161 539.5 15.5 2.6e-161 538.6 15.5 1.4 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 KII70718.1 - 0.00027 20.3 0.5 0.00027 20.3 0.5 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1394) DUF4498 PF14926.6 KII70721.1 - 0.057 12.7 0.2 0.11 11.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4498) DNMT1-RFD PF12047.8 KII70722.1 - 0.062 13.3 0.1 8.8 6.4 0.1 2.9 1 1 2 3 3 3 0 Cytosine specific DNA methyltransferase replication foci domain UNC80 PF15778.5 KII70722.1 - 0.075 12.6 0.2 0.13 11.8 0.1 1.5 2 0 0 2 2 2 0 Cation channel complex component UNC80 DUF3787 PF12655.7 KII70728.1 - 0.033 14.1 0.1 0.2 11.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3787) FIIND PF13553.6 KII70728.1 - 0.1 12.0 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 Function to find DUF790 PF05626.11 KII70728.1 - 0.19 10.4 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF790) Phage_T4_gp36 PF03903.13 KII70729.1 - 0.066 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Phage T4 tail fibre DUF2627 PF11118.8 KII70731.1 - 0.033 14.8 0.1 0.1 13.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) TrbL PF04610.14 KII70733.1 - 0.031 14.0 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein RIFIN PF02009.16 KII70733.1 - 0.048 13.6 0.0 0.071 13.0 0.0 1.2 1 0 0 1 1 1 0 Rifin RIFIN PF02009.16 KII70734.1 - 0.0021 18.0 0.0 0.0022 17.9 0.0 1.1 1 0 0 1 1 1 1 Rifin Orf78 PF06024.12 KII70734.1 - 0.0087 16.3 0.0 0.01 16.2 0.0 1.1 1 0 0 1 1 1 1 Orf78 (ac78) Col_cuticle_N PF01484.17 KII70734.1 - 0.011 15.8 2.2 0.024 14.7 2.2 1.7 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Adeno_E3_CR2 PF02439.15 KII70734.1 - 0.012 15.3 0.1 0.02 14.6 0.1 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 ETRAMP PF09716.10 KII70734.1 - 0.066 13.3 0.2 0.074 13.1 0.2 1.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) RT_RNaseH PF17917.1 KII70735.1 - 2.8e-08 34.0 0.5 4.6e-08 33.3 0.1 1.6 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII70735.1 - 3e-08 33.6 0.8 6.1e-08 32.6 0.1 1.9 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase CdhC PF03598.15 KII70735.1 - 0.096 12.5 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit DUF1687 PF07955.11 KII70736.1 - 0.018 15.5 0.2 0.54 10.7 0.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1687) Pepdidase_M14_N PF18027.1 KII70736.1 - 0.075 13.4 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Cytosolic carboxypeptidase N-terminal domain Pih1_fungal_CS PF18482.1 KII70736.1 - 0.11 13.0 1.4 0.39 11.3 0.0 2.5 3 0 0 3 3 3 0 Fungal Pih1 CS domain ATP_bind_1 PF03029.17 KII70738.1 - 6.5e-30 104.7 0.0 8.3e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein T2SSE PF00437.20 KII70738.1 - 2.7e-06 26.7 0.0 3.3e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF87 PF01935.17 KII70738.1 - 7.4e-05 22.9 0.1 8.1e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Helicase HerA, central domain SRP54 PF00448.22 KII70738.1 - 0.00019 21.1 0.2 0.00026 20.7 0.2 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain NB-ARC PF00931.22 KII70738.1 - 0.0002 20.7 0.1 0.00026 20.2 0.1 1.1 1 0 0 1 1 1 1 NB-ARC domain CLP1_P PF16575.5 KII70738.1 - 0.0005 19.9 0.0 0.00072 19.4 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 KII70738.1 - 0.00052 20.5 0.0 0.00052 20.5 0.0 1.2 1 1 0 1 1 1 1 AAA ATPase domain KAP_NTPase PF07693.14 KII70738.1 - 0.00061 19.1 0.0 0.00072 18.9 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain AAA_19 PF13245.6 KII70738.1 - 0.00075 19.9 0.1 0.00097 19.5 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KII70738.1 - 0.00076 20.0 0.0 0.00086 19.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KII70738.1 - 0.00096 19.3 0.0 0.00096 19.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 KII70738.1 - 0.0012 18.9 0.0 0.0012 18.9 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_14 PF13173.6 KII70738.1 - 0.0013 18.7 0.0 0.0017 18.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 KII70738.1 - 0.0018 18.3 0.0 0.0018 18.3 0.0 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea KTI12 PF08433.10 KII70738.1 - 0.0019 17.7 0.0 0.0022 17.5 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 NACHT PF05729.12 KII70738.1 - 0.0029 17.5 0.1 0.004 17.1 0.1 1.2 1 0 0 1 1 1 1 NACHT domain AAA_24 PF13479.6 KII70738.1 - 0.0033 17.2 0.1 0.0034 17.1 0.1 1.1 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KII70738.1 - 0.0037 17.0 0.0 0.0044 16.8 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 KII70738.1 - 0.0037 17.3 0.0 0.0052 16.8 0.0 1.2 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 KII70738.1 - 0.0043 16.8 0.0 0.0057 16.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 KII70738.1 - 0.0069 16.0 0.1 0.0093 15.6 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 KII70738.1 - 0.0071 16.9 0.2 0.011 16.3 0.1 1.3 1 1 0 1 1 1 1 ABC transporter AAA_31 PF13614.6 KII70738.1 - 0.0076 16.2 0.1 0.0081 16.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KII70738.1 - 0.0096 15.2 0.0 0.012 14.9 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin AAA_10 PF12846.7 KII70738.1 - 0.0099 14.8 0.0 0.011 14.6 0.0 1.1 1 0 0 1 1 1 1 AAA-like domain Rad17 PF03215.15 KII70738.1 - 0.01 15.8 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain TrwB_AAD_bind PF10412.9 KII70738.1 - 0.013 14.4 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA PF00004.29 KII70738.1 - 0.013 15.9 0.7 0.052 14.0 0.3 1.9 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 KII70738.1 - 0.016 14.2 0.0 0.02 13.9 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 KII70738.1 - 0.017 15.4 0.0 0.019 15.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 KII70738.1 - 0.018 14.7 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase RNA_helicase PF00910.22 KII70738.1 - 0.019 15.3 0.1 0.032 14.6 0.1 1.4 1 1 0 1 1 1 0 RNA helicase PRK PF00485.18 KII70738.1 - 0.023 14.4 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family G-alpha PF00503.20 KII70738.1 - 0.026 13.7 0.1 0.03 13.5 0.1 1.3 1 1 0 1 1 1 0 G-protein alpha subunit PduV-EutP PF10662.9 KII70738.1 - 0.026 14.3 0.1 0.039 13.7 0.1 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation 6PF2K PF01591.18 KII70738.1 - 0.031 13.6 0.2 0.043 13.1 0.2 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase FtsK_SpoIIIE PF01580.18 KII70738.1 - 0.033 13.6 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family ArsA_ATPase PF02374.15 KII70738.1 - 0.044 12.9 0.1 0.068 12.3 0.1 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase SAS-6_N PF16531.5 KII70738.1 - 0.046 14.3 0.0 0.68 10.6 0.0 2.2 1 1 0 1 1 1 0 Centriolar protein SAS N-terminal Trm56 PF01994.16 KII70738.1 - 0.051 13.5 0.0 0.51 10.3 0.0 2.0 2 0 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 NTPase_1 PF03266.15 KII70738.1 - 0.058 13.3 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 NTPase Sigma54_activat PF00158.26 KII70738.1 - 0.063 13.0 0.0 0.083 12.6 0.0 1.1 1 0 0 1 1 1 0 Sigma-54 interaction domain APS_kinase PF01583.20 KII70738.1 - 0.065 13.1 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Pox_A32 PF04665.12 KII70738.1 - 0.066 12.7 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein Myosin_head PF00063.21 KII70738.1 - 0.077 11.2 0.0 0.081 11.1 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) LpxK PF02606.14 KII70738.1 - 0.079 12.0 0.1 0.088 11.9 0.1 1.1 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase AAA_7 PF12775.7 KII70738.1 - 0.082 12.4 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region MobB PF03205.14 KII70738.1 - 0.087 12.7 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Septin PF00735.18 KII70738.1 - 0.088 12.1 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Septin PIF1 PF05970.14 KII70738.1 - 0.094 11.9 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase RNA12 PF10443.9 KII70738.1 - 0.12 11.1 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein dNK PF01712.19 KII70738.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_5 PF07728.14 KII70738.1 - 0.13 12.3 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Erythrovirus_X PF06795.11 KII70738.1 - 0.13 12.6 0.1 8.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Erythrovirus X protein DUF463 PF04317.12 KII70738.1 - 0.19 10.6 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 AAA_23 PF13476.6 KII70738.1 - 0.23 12.0 0.3 0.42 11.1 0.2 1.3 1 1 0 1 1 1 0 AAA domain DUF1244 PF06844.11 KII70740.1 - 0.0085 16.2 0.2 4.9 7.4 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1244) Ldl_recept_a PF00057.18 KII70741.1 - 3.5e-08 33.5 11.1 4.9e-08 33.1 11.1 1.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A BNR PF02012.20 KII70742.1 - 0.062 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 BNR/Asp-box repeat DUF3652 PF12372.8 KII70744.1 - 0.03 14.2 2.3 0.64 10.0 0.1 2.6 2 1 0 2 2 2 0 Huntingtin protein region DUF4371 PF14291.6 KII70746.1 - 0.00018 21.3 0.3 0.00022 21.0 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) DDE_3 PF13358.6 KII70751.1 - 1.4e-05 24.9 0.1 1.9e-05 24.5 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF494 PF04361.13 KII70757.1 - 0.13 12.1 0.0 0.8 9.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF494) MobC PF05713.11 KII70758.1 - 0.038 14.5 0.1 0.074 13.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial mobilisation protein (MobC) Kelch_6 PF13964.6 KII70759.1 - 1.2e-21 76.2 12.7 6.2e-05 23.1 0.2 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII70759.1 - 1.9e-20 72.7 8.9 0.00037 20.7 0.1 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII70759.1 - 9.4e-17 60.3 14.9 1.1e-07 31.3 0.4 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII70759.1 - 1e-14 54.2 15.9 0.0082 16.1 0.0 6.5 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KII70759.1 - 4.6e-11 42.2 12.3 0.013 15.4 0.5 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII70759.1 - 4e-09 36.2 3.3 0.14 12.2 1.0 4.7 4 0 0 4 4 4 3 Kelch motif PDZ_6 PF17820.1 KII70764.1 - 8.8e-09 35.1 0.0 2e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KII70764.1 - 1.4e-07 31.8 0.0 2.5e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII70764.1 - 0.0071 16.6 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain SVA PF05326.11 KII70766.1 - 0.031 14.3 3.6 0.61 10.1 2.4 2.0 1 1 1 2 2 2 0 Seminal vesicle autoantigen (SVA) NAPRTase_N PF17767.1 KII70768.1 - 1.3e-27 96.7 0.0 1.5e-27 96.4 0.0 1.0 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain rve PF00665.26 KII70770.1 - 1.6e-13 50.9 0.0 2.3e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII70770.1 - 0.00022 20.9 0.1 0.00043 20.0 0.1 1.6 1 1 1 2 2 2 1 Integrase core domain DDE_3 PF13358.6 KII70771.1 - 8.7e-06 25.6 0.4 4.7e-05 23.2 0.4 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF764 PF05561.11 KII70772.1 - 0.0044 16.9 0.0 0.013 15.3 0.0 1.8 1 1 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF764) Gp58 PF07902.11 KII70772.1 - 0.016 13.5 0.0 0.019 13.3 0.0 1.0 1 0 0 1 1 1 0 gp58-like protein Ins134_P3_kin PF05770.11 KII70773.1 - 6.5e-26 91.1 0.1 1e-25 90.4 0.1 1.3 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Ins134_P3_kin_N PF17927.1 KII70773.1 - 0.00024 21.4 0.0 0.00057 20.2 0.0 1.7 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain Pkinase PF00069.25 KII70774.1 - 3.5e-15 56.1 0.1 6.8e-15 55.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII70774.1 - 5.3e-09 35.7 0.0 1.9e-08 33.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Curto_V2 PF07325.11 KII70774.1 - 0.1 12.4 1.2 0.2 11.5 1.2 1.4 1 0 0 1 1 1 0 Curtovirus V2 protein DDE_3 PF13358.6 KII70776.1 - 4.6e-14 52.4 0.0 8.4e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII70776.1 - 0.0032 17.2 0.0 1.1 9.1 0.0 3.2 3 0 0 3 3 3 1 Homeodomain-like domain HTH_32 PF13565.6 KII70776.1 - 0.011 16.3 0.0 0.037 14.6 0.0 2.0 1 0 0 1 1 1 0 Homeodomain-like domain PAX PF00292.18 KII70776.1 - 0.013 15.4 0.2 0.044 13.7 0.1 1.9 1 1 0 1 1 1 0 'Paired box' domain HTH_28 PF13518.6 KII70776.1 - 0.031 14.4 0.0 0.78 9.9 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 KII70776.1 - 0.072 13.3 0.4 0.26 11.5 0.0 2.2 3 0 0 3 3 3 0 Transposase HTH_29 PF13551.6 KII70776.1 - 0.15 12.1 0.1 4.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn helix ERAP1_C PF11838.8 KII70777.1 - 7.6e-50 170.2 0.0 1e-49 169.8 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 KII70777.1 - 1e-20 74.3 0.3 1.7e-20 73.6 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KII70778.1 - 5.4e-37 127.8 2.9 7e-37 127.4 2.9 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Tau95 PF09734.9 KII70779.1 - 3.1e-13 50.7 0.0 4.8e-13 50.1 0.0 1.3 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain TFIIF_beta PF02270.15 KII70779.1 - 0.019 15.1 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain Tau95_N PF17682.1 KII70780.1 - 1.6e-12 47.7 0.1 2.4e-11 43.9 0.1 2.0 1 1 0 1 1 1 1 Tau95 Triple barrel domain Phage_holin_3_3 PF16083.5 KII70782.1 - 0.0084 16.2 0.1 0.016 15.3 0.1 1.5 1 0 0 1 1 1 1 LydA holin phage, holin superfamily III DUF389 PF04087.14 KII70782.1 - 0.16 12.0 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF389) PI3_PI4_kinase PF00454.27 KII70783.1 - 4.6e-57 193.7 0.1 9.4e-57 192.7 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KII70783.1 - 1.1e-13 50.7 0.0 2.6e-13 49.5 0.0 1.7 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 KII70783.1 - 4.6e-13 49.1 2.0 8.2e-13 48.3 0.7 2.2 2 1 0 2 2 2 1 FAT domain UME PF08064.13 KII70783.1 - 1.1e-10 41.3 1.1 4.9e-10 39.2 0.3 2.7 2 0 0 2 2 2 1 UME (NUC010) domain LtuB PF17455.2 KII70783.1 - 0.012 16.2 0.7 0.28 11.8 0.1 2.7 2 0 0 2 2 2 0 Late transcription unit B UPF0113_N PF17833.1 KII70783.1 - 0.098 13.2 1.3 8.3 7.0 0.0 4.1 3 0 0 3 3 3 0 UPF0113 Pre-PUA domain TRM PF02005.16 KII70784.1 - 5.5e-84 282.5 0.0 6.7e-84 282.2 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DUF2067 PF09840.9 KII70784.1 - 0.0019 17.8 0.0 0.0039 16.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2067) DDE_3 PF13358.6 KII70785.1 - 1.1e-09 38.2 0.0 1.3e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease UQ_con PF00179.26 KII70786.1 - 2.2e-45 153.8 0.1 5.2e-45 152.5 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KII70786.1 - 0.0065 16.7 0.0 0.0085 16.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KII70786.1 - 0.017 14.8 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 KII70786.1 - 0.044 13.6 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain FLYWCH PF04500.16 KII70789.1 - 9.8e-10 38.4 3.3 1.9e-09 37.5 3.3 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain DUF3850 PF12961.7 KII70789.1 - 0.097 12.7 1.0 0.25 11.4 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) DCP1 PF06058.13 KII70789.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Dcp1-like decapping family Cyclin PF08613.11 KII70789.1 - 0.5 10.7 3.3 0.67 10.3 0.1 2.3 3 0 0 3 3 3 0 Cyclin RT_RNaseH PF17917.1 KII70791.1 - 1.3e-36 125.1 0.1 4.6e-36 123.3 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII70791.1 - 8.7e-35 118.8 0.0 2e-34 117.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII70791.1 - 1.2e-29 103.5 0.0 2.5e-29 102.4 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII70791.1 - 2.5e-24 85.7 0.0 5e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70791.1 - 2.1e-20 72.6 0.4 6.7e-20 71.0 0.4 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII70791.1 - 0.00063 19.9 0.2 0.0036 17.5 0.0 2.4 2 0 0 2 2 2 1 H2C2 zinc finger MLVIN_C PF18697.1 KII70791.1 - 0.0038 17.3 0.0 0.013 15.6 0.0 1.9 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII70791.1 - 0.0061 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS1595 PF12762.7 KII70792.1 - 3.8e-09 36.7 0.0 4.6e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain PPTA PF01239.22 KII70794.1 - 1.1e-37 126.7 20.3 1.1e-10 40.9 2.8 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Phage_clamp_A PF16790.5 KII70794.1 - 0.007 16.8 1.0 0.012 16.1 0.1 1.8 2 0 0 2 2 2 1 Bacteriophage clamp loader A subunit Amidase_2 PF01510.25 KII70794.1 - 0.018 15.5 0.5 0.032 14.7 0.5 1.5 1 0 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase DUF4219 PF13961.6 KII70794.1 - 0.061 13.0 10.4 2.1 8.1 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4219) Sec16_C PF12931.7 KII70795.1 - 1.1e-10 41.6 0.4 3.3e-10 40.1 0.4 1.7 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 KII70795.1 - 0.084 13.5 1.2 0.43 11.2 0.1 2.8 3 1 0 3 3 3 0 Vesicle coat trafficking protein Sec16 mid-region Ribosomal_L37 PF08561.10 KII70795.1 - 0.13 12.8 1.5 0.18 12.3 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 MH1 PF03165.16 KII70797.1 - 4e-34 116.9 1.8 4.9e-34 116.6 1.8 1.1 1 0 0 1 1 1 1 MH1 domain RVT_1 PF00078.27 KII70798.1 - 2.9e-28 98.9 0.1 4.1e-28 98.4 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4208 PF13907.6 KII70798.1 - 0.056 13.9 0.2 0.38 11.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) DUF349 PF03993.12 KII70798.1 - 0.077 13.3 0.4 0.19 12.0 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) DDE_3 PF13358.6 KII70799.1 - 9.4e-05 22.2 0.0 0.0001 22.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII70800.1 - 2.3e-22 79.3 0.0 1.8e-20 73.2 0.0 2.4 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII70800.1 - 0.0001 22.0 0.2 0.0045 16.7 0.1 2.5 2 0 0 2 2 2 1 Homeodomain-like domain rve PF00665.26 KII70800.1 - 0.00014 22.0 0.0 0.00031 20.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain HTH_28 PF13518.6 KII70800.1 - 0.00099 19.2 0.1 0.0021 18.2 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain DDE_Tnp_ISAZ013 PF07592.11 KII70800.1 - 0.0011 18.1 0.2 0.67 8.9 0.0 2.2 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain HTH_Tnp_Tc3_2 PF01498.18 KII70800.1 - 0.0041 17.3 0.2 0.013 15.7 0.2 1.9 1 0 0 1 1 1 1 Transposase HTH_5 PF01022.20 KII70800.1 - 0.0043 16.9 0.3 0.015 15.1 0.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_Tnp_1 PF01527.20 KII70800.1 - 0.076 13.3 0.2 0.2 12.0 0.0 1.8 2 0 0 2 2 2 0 Transposase HTH_29 PF13551.6 KII70800.1 - 0.11 12.6 0.1 0.8 9.8 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix YflT PF11181.8 KII70800.1 - 0.12 12.9 0.2 0.44 11.1 0.0 2.0 2 0 0 2 2 2 0 Heat induced stress protein YflT DDE_3 PF13358.6 KII70804.1 - 2.1e-08 34.1 0.3 3.5e-06 26.8 0.3 2.3 1 1 0 1 1 1 1 DDE superfamily endonuclease Rad51 PF08423.11 KII70804.1 - 0.046 13.0 0.2 0.07 12.4 0.2 1.2 1 0 0 1 1 1 0 Rad51 Death PF00531.22 KII70804.1 - 0.086 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Death domain SH3_13 PF18335.1 KII70805.1 - 0.1 12.4 0.1 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain Kelch_6 PF13964.6 KII70807.1 - 1e-20 73.2 11.5 7.2e-06 26.1 0.3 6.3 6 1 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII70807.1 - 2e-12 46.9 12.8 1.4e-05 25.0 0.1 6.0 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII70807.1 - 4e-12 45.5 10.6 0.0031 17.0 0.4 6.3 6 1 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII70807.1 - 1.1e-11 44.7 14.1 0.00012 22.3 0.2 6.4 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII70807.1 - 1.5e-05 24.7 7.7 4.7 7.3 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII70807.1 - 0.00071 19.5 2.5 2 8.5 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Ada_Zn_binding PF02805.16 KII70807.1 - 0.18 11.9 0.1 0.31 11.1 0.1 1.4 1 0 0 1 1 1 0 Metal binding domain of Ada rve PF00665.26 KII70810.1 - 2.3e-19 69.7 0.0 3.2e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70811.1 - 3e-05 24.0 0.0 4.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain DUF4371 PF14291.6 KII70813.1 - 0.042 13.5 0.0 0.046 13.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) cwf21 PF08312.12 KII70814.1 - 0.092 12.9 0.3 0.092 12.9 0.3 1.8 2 0 0 2 2 2 0 cwf21 domain PBP PF01161.20 KII70816.1 - 0.035 14.4 0.0 0.039 14.3 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylethanolamine-binding protein RT_RNaseH_2 PF17919.1 KII70823.1 - 2.2e-37 127.1 0.1 3.1e-37 126.6 0.1 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII70823.1 - 1.6e-36 124.7 0.0 2.2e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Peptidase_U32_C PF16325.5 KII70823.1 - 0.035 14.4 0.0 0.061 13.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family U32 C-terminal domain HTH_Tnp_Tc3_2 PF01498.18 KII70825.1 - 0.00076 19.7 0.0 0.001 19.3 0.0 1.3 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 KII70825.1 - 0.0074 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 KII70825.1 - 0.015 15.9 0.0 0.026 15.1 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Sortilin_C PF15901.5 KII70826.1 - 1.5e-14 54.7 5.3 1.9e-14 54.3 5.3 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal preSET_CXC PF18264.1 KII70826.1 - 1.9 9.0 6.5 6.5 7.3 0.2 2.7 2 0 0 2 2 2 0 CXC domain DDE_3 PF13358.6 KII70830.1 - 5.9e-30 104.0 0.1 9.4e-30 103.3 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII70830.1 - 0.014 15.1 0.0 0.032 13.9 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII70830.1 - 0.017 15.3 0.3 0.055 13.7 0.1 2.1 2 0 0 2 2 2 0 Transposase DDE_Tnp_ISAZ013 PF07592.11 KII70830.1 - 0.028 13.4 0.1 2.4 7.0 0.1 2.1 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain RapH_N PF18801.1 KII70830.1 - 0.037 14.1 0.3 0.89 9.7 0.1 2.5 2 0 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal AAA_14 PF13173.6 KII70830.1 - 0.12 12.5 0.2 1.4 9.0 0.0 2.2 2 1 0 2 2 2 0 AAA domain Retrotrans_gag PF03732.17 KII70831.1 - 0.00014 22.1 0.1 0.00041 20.6 0.1 1.7 2 0 0 2 2 2 1 Retrotransposon gag protein EF-hand_like PF09279.11 KII70831.1 - 0.0038 17.7 0.1 0.0064 16.9 0.1 1.4 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like DUF4974 PF16344.5 KII70831.1 - 0.11 12.5 0.2 0.31 11.1 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4974) Arm PF00514.23 KII70832.1 - 2.9e-17 62.1 1.1 0.001 19.0 0.0 7.1 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KII70832.1 - 2.8e-05 23.6 0.9 9.1e-05 21.9 0.9 1.9 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 KII70832.1 - 0.0014 19.0 0.0 4.1 8.0 0.0 3.6 3 0 0 3 3 3 1 HEAT-like repeat RICTOR_V PF14668.6 KII70832.1 - 0.0029 17.8 5.6 1.1 9.6 0.0 4.9 5 1 1 6 6 6 2 Rapamycin-insensitive companion of mTOR, domain 5 HEAT PF02985.22 KII70832.1 - 0.027 14.7 0.2 8.8 6.9 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat GBP_C PF02841.14 KII70832.1 - 0.18 11.2 1.4 0.17 11.2 0.3 1.4 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Arm PF00514.23 KII70834.1 - 3.2e-15 55.5 0.9 0.0064 16.5 0.1 7.1 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KII70834.1 - 1.4e-06 28.6 0.0 0.41 11.2 0.0 3.5 3 0 0 3 3 3 2 HEAT-like repeat IBB PF01749.20 KII70834.1 - 0.019 15.4 0.3 0.035 14.6 0.3 1.4 1 0 0 1 1 1 0 Importin beta binding domain ADD_ATRX PF17981.1 KII70836.1 - 0.052 13.4 0.1 0.14 12.1 0.1 1.7 1 0 0 1 1 1 0 Cysteine Rich ADD domain DUF445 PF04286.12 KII70839.1 - 0.048 13.5 1.2 0.056 13.3 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Rab15_effector PF15208.6 KII70841.1 - 0.084 12.2 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Rab15 effector FliD_C PF07195.12 KII70845.1 - 0.0054 16.2 2.6 0.0065 15.9 2.6 1.1 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus DUF3670 PF12419.8 KII70845.1 - 0.068 13.0 0.2 0.1 12.4 0.2 1.3 1 0 0 1 1 1 0 SNF2 Helicase protein DUF4200 PF13863.6 KII70845.1 - 0.74 10.2 9.1 1.4 9.3 5.7 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) YabA PF06156.13 KII70845.1 - 0.8 10.4 6.9 6.1 7.5 1.1 2.1 2 0 0 2 2 2 0 Initiation control protein YabA Taeniidae_ag PF05596.11 KII70845.1 - 2.8 8.0 7.3 1.5 8.8 0.5 3.3 2 1 2 4 4 4 0 Taeniidae antigen DUF4438 PF14505.6 KII70846.1 - 0.096 11.6 0.2 0.59 9.1 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4438) rve PF00665.26 KII70849.1 - 0.00022 21.4 0.0 0.00049 20.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 KII70849.1 - 0.06 14.0 0.0 0.16 12.6 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII70849.1 - 0.088 13.1 0.0 1.3 9.4 0.0 2.6 2 0 0 2 2 2 0 Retroviral aspartyl protease Peptidase_S15 PF02129.18 KII70849.1 - 0.099 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) gag-asp_proteas PF13975.6 KII70849.1 - 0.15 12.7 0.0 0.35 11.5 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease YrvL PF14184.6 KII70850.1 - 0.019 15.1 9.7 0.026 14.6 9.7 1.2 1 0 0 1 1 1 0 Regulatory protein YrvL rve PF00665.26 KII70851.1 - 6e-17 61.9 0.0 9.3e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70851.1 - 2.2e-06 27.7 0.2 2.2e-06 27.7 0.2 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII70851.1 - 4.8e-05 23.1 0.0 0.0001 22.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain TMEM251 PF15190.6 KII70851.1 - 0.081 12.9 0.0 0.24 11.4 0.0 1.7 2 0 0 2 2 2 0 Transmembrane protein 251 LRS4 PF10422.9 KII70852.1 - 0.23 11.0 5.7 0.25 10.9 5.7 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Retrotrans_gag PF03732.17 KII70853.1 - 0.00018 21.7 0.6 0.0005 20.3 0.2 1.9 1 1 1 2 2 2 1 Retrotransposon gag protein RPAP3_C PF13877.6 KII70853.1 - 0.034 14.7 1.0 0.25 11.9 0.2 2.2 1 1 0 2 2 2 0 Potential Monad-binding region of RPAP3 Tropomyosin PF00261.20 KII70854.1 - 0.0024 17.3 2.7 0.0029 17.0 2.7 1.2 1 0 0 1 1 1 1 Tropomyosin Abi_2 PF07751.11 KII70854.1 - 0.0071 16.6 3.5 0.012 15.9 3.5 1.4 1 0 0 1 1 1 1 Abi-like protein Myosin_tail_1 PF01576.19 KII70854.1 - 0.014 13.2 4.3 0.019 12.8 4.3 1.2 1 0 0 1 1 1 0 Myosin tail COG2 PF06148.11 KII70854.1 - 0.015 15.4 0.2 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Lebercilin PF15619.6 KII70854.1 - 0.029 14.0 8.2 0.85 9.3 0.7 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TMF_TATA_bd PF12325.8 KII70854.1 - 0.037 14.2 7.7 0.26 11.5 2.3 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 KII70854.1 - 0.055 13.5 2.9 4.3 7.4 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec2p PF06428.11 KII70854.1 - 0.073 13.0 7.9 1.8 8.6 0.6 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Laminin_II PF06009.12 KII70854.1 - 0.082 12.9 4.5 0.15 12.1 0.4 2.0 2 0 0 2 2 2 0 Laminin Domain II CENP-F_leu_zip PF10473.9 KII70854.1 - 0.099 12.7 6.8 1.4 9.0 2.7 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc24 PF08286.11 KII70854.1 - 0.11 12.8 3.3 2 8.7 0.5 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 APG6_N PF17675.1 KII70854.1 - 0.11 13.0 4.0 0.45 11.0 2.1 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region KELK PF15796.5 KII70854.1 - 0.14 12.6 9.4 0.47 10.9 1.7 3.0 2 1 2 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Enkurin PF13864.6 KII70854.1 - 0.17 12.4 6.7 0.7 10.4 5.4 2.4 1 1 1 2 2 2 0 Calmodulin-binding Tup_N PF08581.10 KII70854.1 - 0.25 11.7 10.7 5.9 7.3 4.8 2.8 2 2 0 2 2 2 0 Tup N-terminal AKNA PF12443.8 KII70854.1 - 0.34 11.6 2.3 0.26 12.0 0.3 1.8 2 0 0 2 2 2 0 AT-hook-containing transcription factor FlaC_arch PF05377.11 KII70854.1 - 0.39 11.2 5.0 2.3 8.7 2.0 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) CLZ PF16526.5 KII70854.1 - 0.43 11.0 5.8 3 8.3 0.8 2.3 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Exonuc_VII_L PF02601.15 KII70854.1 - 0.78 9.3 4.2 0.94 9.0 4.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tropomyosin_1 PF12718.7 KII70854.1 - 0.84 9.8 7.9 1.8 8.7 0.6 2.3 2 0 0 2 2 2 0 Tropomyosin like KxDL PF10241.9 KII70854.1 - 0.93 9.8 7.4 0.22 11.8 1.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein Fib_alpha PF08702.10 KII70854.1 - 0.96 9.6 10.2 28 4.9 10.2 2.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family STAT_alpha PF01017.20 KII70854.1 - 2.5 7.9 9.2 1.1 9.1 3.1 2.1 1 1 1 2 2 2 0 STAT protein, all-alpha domain CCDC-167 PF15188.6 KII70854.1 - 4.9 7.6 8.4 1.9 8.9 2.6 2.4 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Hs1pro-1_C PF07014.12 KII70855.1 - 0.047 13.1 0.5 0.053 13.0 0.5 1.1 1 0 0 1 1 1 0 Hs1pro-1 protein C-terminus Laminin_II PF06009.12 KII70857.1 - 0.0017 18.3 3.5 0.024 14.6 0.3 2.1 2 0 0 2 2 2 2 Laminin Domain II FliD_C PF07195.12 KII70857.1 - 0.015 14.7 4.7 0.045 13.2 4.6 1.8 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Engrail_1_C_sig PF10525.9 KII70857.1 - 0.12 11.6 0.4 0.25 10.6 0.4 1.5 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain DUF1664 PF07889.12 KII70857.1 - 0.52 10.3 3.2 3.4 7.7 2.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 KII70857.1 - 0.92 10.0 5.7 1.8 9.1 1.2 2.5 2 1 0 2 2 2 0 Snapin/Pallidin KxDL PF10241.9 KII70857.1 - 1.8 8.9 7.5 3.5 8.0 0.7 3.0 1 1 2 3 3 3 0 Uncharacterized conserved protein DUF3465 PF11948.8 KII70859.1 - 0.019 14.9 0.0 0.027 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) RecG_N PF17190.4 KII70860.1 - 0.027 15.2 0.9 0.027 15.2 0.9 2.0 1 1 1 2 2 2 0 RecG N-terminal helical domain NUMOD1 PF07453.13 KII70860.1 - 0.04 14.2 0.3 9.4 6.6 0.0 2.7 2 0 0 2 2 2 0 NUMOD1 domain DUF1786 PF08735.10 KII70860.1 - 0.049 12.9 0.1 0.054 12.8 0.1 1.2 1 0 0 1 1 1 0 Putative pyruvate format-lyase activating enzyme (DUF1786) Con-6 PF10346.9 KII70860.1 - 0.084 12.9 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Conidiation protein 6 Nas2_N PF18265.1 KII70860.1 - 0.15 12.0 0.4 0.15 12.0 0.4 2.1 2 1 0 2 2 2 0 Nas2 N_terminal domain TRCF PF03461.15 KII70860.1 - 0.19 12.1 0.5 0.19 12.1 0.5 2.7 2 1 1 3 3 3 0 TRCF domain CC2-LZ PF16516.5 KII70860.1 - 0.38 11.2 5.8 0.14 12.5 0.8 2.2 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Mga PF05043.13 KII70860.1 - 0.98 10.0 8.4 0.6 10.7 5.5 1.9 1 1 1 2 2 2 0 Mga helix-turn-helix domain RE_TdeIII PF09520.10 KII70860.1 - 1.1 8.9 9.2 23 4.6 9.2 2.0 1 1 0 1 1 1 0 Type II restriction endonuclease, TdeIII Imm51 PF15595.6 KII70862.1 - 0.052 13.5 0.2 0.11 12.5 0.2 1.5 1 0 0 1 1 1 0 Immunity protein 51 DUF1796 PF08795.10 KII70862.1 - 0.1 12.5 0.1 0.1 12.5 0.1 1.5 2 0 0 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) SNAP PF14938.6 KII70862.1 - 0.14 11.6 8.3 0.32 10.4 8.3 1.8 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 KII70862.1 - 1.1 9.2 10.4 4.2 7.4 0.2 4.6 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 KII70862.1 - 2.9 8.1 7.3 11 6.3 0.0 4.1 6 0 0 6 6 6 0 Tetratricopeptide repeat WD-3 PF09765.9 KII70863.1 - 0.036 13.4 0.4 0.041 13.2 0.4 1.1 1 0 0 1 1 1 0 WD-repeat region DUF1477 PF07346.11 KII70863.1 - 0.14 12.4 3.8 3.5 7.9 3.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1477) SNAP PF14938.6 KII70867.1 - 1.6e-06 27.7 0.7 2e-06 27.4 0.7 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PhaP_Bmeg PF09602.10 KII70867.1 - 0.08 12.9 1.5 0.17 11.8 0.2 1.8 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Rad50_zn_hook PF04423.14 KII70867.1 - 0.082 12.8 1.7 0.12 12.2 0.2 2.2 2 1 0 2 2 2 0 Rad50 zinc hook motif TPR_1 PF00515.28 KII70867.1 - 0.94 9.4 10.2 2.7 7.9 0.4 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII70867.1 - 1.4 9.2 7.5 60 4.1 0.1 4.4 3 1 2 5 5 5 0 Tetratricopeptide repeat Serpin PF00079.20 KII70869.1 - 2.2e-19 70.0 0.5 2.5e-19 69.8 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-UBR PF02207.20 KII70870.1 - 9.4e-12 44.9 21.1 2.3e-11 43.7 21.1 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Myb_DNA-binding PF00249.31 KII70872.1 - 5.2e-12 45.8 7.2 3.8e-06 27.0 0.2 4.7 5 1 0 5 5 5 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII70872.1 - 1.1e-10 41.6 1.5 1.4e-05 25.2 0.1 4.2 2 1 1 3 3 3 2 Myb-like DNA-binding domain PDDEXK_9 PF08011.11 KII70872.1 - 6.4e-05 22.8 0.9 0.48 10.3 0.1 2.6 2 0 0 2 2 2 2 PD-(D/E)XK nuclease superfamily NitrOD5 PF11537.8 KII70872.1 - 0.0023 18.0 0.1 4.6 7.4 0.0 2.8 2 0 0 2 2 2 2 Nitrosopumilus output domain 5 DbpA PF03880.15 KII70872.1 - 0.0037 17.2 1.8 2.9 7.9 0.1 3.0 3 0 0 3 3 3 2 DbpA RNA binding domain MethyltransfD12 PF02086.15 KII70872.1 - 0.004 16.9 5.1 0.59 9.8 0.4 2.3 2 0 0 2 2 2 2 D12 class N6 adenine-specific DNA methyltransferase Filament PF00038.21 KII70872.1 - 0.0058 16.2 0.7 2.8 7.4 0.1 2.4 2 0 0 2 2 2 2 Intermediate filament protein SatD PF16264.5 KII70872.1 - 0.039 13.6 2.8 2.5 7.6 0.2 2.3 2 0 0 2 2 2 0 SatD family (SatD) SKA2 PF16740.5 KII70872.1 - 0.039 13.7 0.5 13 5.6 0.1 2.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 UPF0240 PF06784.11 KII70872.1 - 0.042 13.9 0.8 12 5.9 0.1 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0240) Succ_CoA_lig PF13607.6 KII70872.1 - 0.21 11.4 0.1 29 4.4 0.0 2.3 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain PurA PF04845.13 KII70873.1 - 6.5e-06 25.6 0.2 7.3e-06 25.5 0.2 1.1 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein VCBS PF13517.6 KII70875.1 - 1e-08 35.6 2.7 5.9e-07 30.0 0.3 1.9 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII70875.1 - 3e-05 24.0 8.2 0.0012 19.0 0.0 2.8 3 0 0 3 3 3 2 FG-GAP repeat Ras PF00071.22 KII70880.1 - 4e-58 195.6 1.5 4.7e-58 195.4 1.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII70880.1 - 1e-32 112.9 0.3 1.6e-32 112.3 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII70880.1 - 1e-12 47.8 0.2 1.4e-12 47.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KII70880.1 - 7.5e-06 25.6 1.0 0.0003 20.4 1.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 KII70880.1 - 0.00011 22.0 0.4 0.13 12.1 0.0 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 KII70880.1 - 0.00012 21.6 0.5 0.00018 21.0 0.4 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KII70880.1 - 0.00023 21.2 0.1 0.00038 20.5 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KII70880.1 - 0.00062 19.7 1.1 0.75 9.7 0.2 2.2 1 1 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 KII70880.1 - 0.032 13.8 0.1 0.66 9.5 0.0 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_7 PF12775.7 KII70880.1 - 0.038 13.5 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 KII70880.1 - 0.06 12.8 0.0 0.079 12.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit VirE PF05272.11 KII70880.1 - 0.064 13.0 0.2 0.18 11.5 0.0 1.8 2 0 0 2 2 2 0 Virulence-associated protein E AAA_18 PF13238.6 KII70880.1 - 0.16 12.5 0.1 0.24 12.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain THOC2_N PF16134.5 KII70881.1 - 0.1 11.2 0.1 0.13 10.9 0.1 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus HTH_23 PF13384.6 KII70882.1 - 4.1e-06 26.4 0.1 2.3e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain TrmB PF01978.19 KII70882.1 - 1.5e-05 24.7 0.0 6.2e-05 22.8 0.1 1.8 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 KII70882.1 - 0.0024 17.4 0.3 0.0085 15.6 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_29 PF13551.6 KII70882.1 - 0.004 17.1 0.1 0.019 15.0 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix TnsD PF15978.5 KII70882.1 - 0.0057 15.7 0.0 0.006 15.6 0.0 1.1 1 0 0 1 1 1 1 Tn7-like transposition protein D HTH_38 PF13936.6 KII70882.1 - 0.074 12.8 0.1 0.15 11.8 0.1 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain PAX PF00292.18 KII70882.1 - 0.11 12.4 0.2 0.18 11.8 0.2 1.3 1 1 0 1 1 1 0 'Paired box' domain Trp_repressor PF01371.19 KII70882.1 - 0.14 12.3 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein Cnd3 PF12719.7 KII70883.1 - 1.3e-41 142.8 11.7 2.2e-41 142.0 11.7 1.4 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 KII70883.1 - 0.015 15.5 0.1 0.076 13.3 0.1 2.3 1 0 0 1 1 1 0 HEAT repeat HEAT_2 PF13646.6 KII70883.1 - 0.11 12.9 0.1 4.8 7.7 0.0 3.2 3 1 0 3 3 3 0 HEAT repeats Dimer_Tnp_hAT PF05699.14 KII70884.1 - 2.2e-07 30.6 0.1 3.1e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ank_2 PF12796.7 KII70885.1 - 2.6e-11 44.0 0.1 1.9e-07 31.6 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Notch PF00066.17 KII70885.1 - 7.2e-09 36.0 7.8 7.2e-09 36.0 7.8 2.7 3 0 0 3 3 3 1 LNR domain Ank_5 PF13857.6 KII70885.1 - 1.2e-06 28.6 0.1 1.8 9.0 0.0 4.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KII70885.1 - 7.3e-06 26.4 0.1 0.0017 18.9 0.1 3.2 2 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII70885.1 - 3.3e-05 23.9 0.0 0.64 10.8 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KII70885.1 - 0.0031 17.9 0.0 10 6.8 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat EGF_2 PF07974.13 KII70885.1 - 0.11 12.8 32.4 0.055 13.9 11.2 3.7 3 0 0 3 3 3 0 EGF-like domain Tmemb_9 PF05434.11 KII70885.1 - 1.7 8.5 10.2 2.6 7.9 0.7 2.4 2 0 0 2 2 2 0 TMEM9 Pkr1 PF08636.10 KII70885.1 - 2.4 8.4 5.7 0.37 11.0 0.6 2.2 2 0 0 2 2 2 0 ER protein Pkr1 Vpu PF00558.19 KII70885.1 - 2.8 7.8 5.7 0.35 10.7 1.2 1.7 2 0 0 2 2 2 0 Vpu protein SNF5 PF04855.12 KII70886.1 - 2.6e-18 66.7 0.2 4.5e-16 59.4 0.1 2.1 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 DDE_Tnp_IS1595 PF12762.7 KII70888.1 - 1.4e-10 41.4 0.0 2.3e-10 40.7 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain ATP-synt_ab PF00006.25 KII70890.1 - 3.2e-106 353.7 0.0 4.9e-106 353.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.6 KII70890.1 - 0.078 13.5 0.0 0.19 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain SNF PF00209.18 KII70890.1 - 0.17 10.5 0.0 0.28 9.8 0.0 1.2 1 0 0 1 1 1 0 Sodium:neurotransmitter symporter family bZIP_1 PF00170.21 KII70891.1 - 1.1e-06 28.6 3.6 1.8e-06 27.9 3.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KII70891.1 - 0.00044 20.3 6.1 0.00088 19.3 6.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper YARHG PF13308.6 KII70891.1 - 0.014 15.2 0.8 0.033 14.1 0.4 1.8 2 0 0 2 2 2 0 YARHG domain TRF PF08558.10 KII70891.1 - 0.045 13.4 0.0 0.052 13.1 0.0 1.1 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) DUF4315 PF14193.6 KII70891.1 - 0.18 11.8 3.2 0.31 11.1 3.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4315) RRM_1 PF00076.22 KII70892.1 - 4e-52 173.9 0.3 7.1e-18 64.2 0.1 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KII70892.1 - 4.1e-11 42.6 0.4 3.7e-05 23.3 0.1 2.6 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 KII70892.1 - 3.2e-07 30.5 0.0 0.063 13.5 0.0 3.5 4 0 0 4 4 4 2 BRCA1-associated protein 2 RL PF17797.1 KII70892.1 - 7.4e-06 25.8 0.3 0.00061 19.7 0.0 2.9 3 0 0 3 3 3 1 RL domain RRM_3 PF08777.11 KII70892.1 - 0.00024 21.1 0.2 0.28 11.2 0.0 3.3 4 0 0 4 4 4 2 RNA binding motif PHM7_cyt PF14703.6 KII70892.1 - 0.00043 20.6 0.4 0.14 12.4 0.1 2.8 2 1 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM PF05172.13 KII70892.1 - 0.00089 19.2 0.2 0.56 10.2 0.1 3.2 2 1 1 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 KII70892.1 - 0.0012 18.9 0.1 0.49 10.5 0.0 3.3 3 0 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.5 KII70892.1 - 0.012 15.5 0.0 1.3 8.9 0.0 2.8 3 0 0 3 3 3 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 KII70892.1 - 0.047 13.8 0.3 0.66 10.1 0.0 3.0 3 0 0 3 3 3 0 Limkain b1 Adaptin_N PF01602.20 KII70893.1 - 4.7e-79 266.3 5.0 6.2e-79 265.9 5.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 KII70893.1 - 7.8e-06 26.2 2.5 2.2e-05 24.7 2.5 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 KII70893.1 - 0.00032 20.8 1.8 0.0027 17.7 0.2 3.3 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Formyl_trans_N PF00551.19 KII70894.1 - 6.2e-17 61.9 0.1 1.5e-16 60.7 0.0 1.5 1 1 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 KII70895.1 - 1.1e-11 44.9 0.0 1.4e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain DAGK_cat PF00781.24 KII70896.1 - 1.3e-17 63.6 0.0 2.4e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 KII70896.1 - 0.076 12.2 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 ATP-NAD kinase PUF PF00806.19 KII70897.1 - 9e-62 201.4 14.4 2.6e-08 33.1 0.0 8.9 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat sCache_2 PF17200.4 KII70897.1 - 0.0063 16.4 0.3 1.3 8.8 0.0 3.8 4 0 0 4 4 4 1 Single Cache domain 2 CPL PF08144.11 KII70897.1 - 0.014 15.7 1.8 12 6.2 0.1 3.7 2 1 1 3 3 3 0 CPL (NUC119) domain Erf4 PF10256.9 KII70897.1 - 0.077 13.1 0.4 0.34 11.0 0.1 2.3 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family SdrG_C_C PF10425.9 KII70898.1 - 0.034 14.2 3.5 1.3 9.0 0.3 2.2 1 1 1 2 2 2 0 C-terminus of bacterial fibrinogen-binding adhesin Pyrophosphatase PF00719.19 KII70899.1 - 1.3e-51 174.6 0.0 1.7e-51 174.2 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Spore_III_AF PF09581.10 KII70900.1 - 0.29 11.1 4.2 0.78 9.7 4.2 1.7 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) GREB1 PF15782.5 KII70900.1 - 1.1 6.3 10.6 1.2 6.2 10.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3563 PF12086.8 KII70901.1 - 0.11 12.2 0.1 0.26 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3563) Endomucin PF07010.12 KII70902.1 - 0.0023 18.0 26.3 0.003 17.6 26.3 1.1 1 0 0 1 1 1 1 Endomucin Tmemb_cc2 PF10267.9 KII70902.1 - 3.5 6.7 8.1 5.6 6.0 8.1 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein CBM64 PF18666.1 KII70904.1 - 0.057 13.5 0.3 6.8 6.8 0.0 3.0 3 0 0 3 3 3 0 Carbohydrate-binding module 64 DUF3671 PF12420.8 KII70904.1 - 0.063 13.4 0.1 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF4939 PF16297.5 KII70905.1 - 0.12 12.3 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) RT_RNaseH PF17917.1 KII70906.1 - 1.2e-25 89.9 0.1 1.8e-25 89.2 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII70906.1 - 1.2e-23 83.1 0.0 2.7e-23 81.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF1664 PF07889.12 KII70908.1 - 0.0064 16.5 12.9 0.048 13.7 4.6 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) DUF4763 PF15960.5 KII70908.1 - 0.019 14.3 5.4 0.059 12.7 3.2 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4763) TPR_MLP1_2 PF07926.12 KII70908.1 - 0.02 15.0 8.0 0.037 14.1 4.0 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein RPW8 PF05659.11 KII70908.1 - 0.022 14.4 5.9 0.32 10.7 1.5 2.3 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Laminin_II PF06009.12 KII70908.1 - 0.04 13.9 7.9 0.058 13.4 4.5 2.3 1 1 1 2 2 2 0 Laminin Domain II Cnn_1N PF07989.11 KII70908.1 - 0.069 13.3 1.2 0.069 13.3 1.2 2.4 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Atg14 PF10186.9 KII70908.1 - 0.1 11.7 10.7 0.17 11.0 10.7 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RtcB PF01139.17 KII70908.1 - 0.14 11.3 1.1 0.21 10.8 1.1 1.2 1 0 0 1 1 1 0 tRNA-splicing ligase RtcB NPV_P10 PF05531.12 KII70908.1 - 0.19 12.2 14.6 0.14 12.6 1.7 3.1 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.11 KII70908.1 - 0.19 11.8 9.5 0.59 10.2 0.3 3.0 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 CREPT PF16566.5 KII70908.1 - 0.25 11.5 8.4 0.31 11.2 5.2 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour FlaC_arch PF05377.11 KII70908.1 - 0.36 11.2 0.2 0.36 11.2 0.2 4.3 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) DUF4446 PF14584.6 KII70908.1 - 0.5 10.3 8.1 1.8 8.6 1.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Arm-DNA-bind_2 PF12167.8 KII70908.1 - 0.57 10.1 2.9 4.1 7.4 0.4 2.7 2 0 0 2 2 2 0 Arm DNA-binding domain DUF4200 PF13863.6 KII70908.1 - 0.65 10.4 17.4 4.4 7.7 6.0 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) ABC_tran_CTD PF16326.5 KII70908.1 - 0.69 10.2 11.2 3.1 8.1 0.3 3.2 3 1 1 4 4 4 0 ABC transporter C-terminal domain Goodbye PF17109.5 KII70908.1 - 0.74 10.3 6.1 0.2 12.1 0.8 2.2 2 1 0 2 2 2 0 fungal STAND N-terminal Goodbye domain UPF0242 PF06785.11 KII70908.1 - 0.78 9.8 13.1 1.1 9.4 5.7 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 KII70908.1 - 0.78 9.8 11.8 0.34 10.9 3.4 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin_2 PF14523.6 KII70908.1 - 1 9.8 10.8 0.93 9.9 7.7 2.2 1 1 1 2 2 2 0 Syntaxin-like protein YabA PF06156.13 KII70908.1 - 1.1 9.9 7.9 4.5 8.0 0.7 2.7 1 1 2 3 3 3 0 Initiation control protein YabA V_ATPase_I PF01496.19 KII70908.1 - 1.2 7.0 8.3 1.7 6.5 8.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tweety PF04906.13 KII70908.1 - 1.2 7.7 4.0 0.67 8.6 2.0 1.5 1 1 1 2 2 2 0 Tweety Fib_alpha PF08702.10 KII70908.1 - 1.7 8.8 16.1 0.36 11.0 10.6 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DHR10 PF18595.1 KII70908.1 - 2.4 8.3 12.4 2.9 8.0 2.0 3.0 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain DUF3375 PF11855.8 KII70908.1 - 3.1 6.6 8.9 1.2 7.9 5.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3375) zf-CpG_bind_C PF12269.8 KII70908.1 - 4.4 7.0 8.3 10 5.8 0.8 2.2 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain Seryl_tRNA_N PF02403.22 KII70908.1 - 7.4 6.8 14.6 40 4.5 11.1 2.7 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ISG65-75 PF11727.8 KII70908.1 - 8.7 5.5 8.4 3.1 6.9 0.8 2.0 1 1 1 2 2 2 0 Invariant surface glycoprotein DUF2396 PF09654.10 KII70911.1 - 0.011 15.8 0.3 0.016 15.3 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2396) PIP5K PF01504.18 KII70914.1 - 2.2e-11 43.5 0.1 3.6e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Arg_repressor_C PF02863.18 KII70915.1 - 0.006 16.4 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 Arginine repressor, C-terminal domain DUF460 PF04312.13 KII70915.1 - 0.0063 16.2 0.4 0.0085 15.8 0.3 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF460) THUMP PF02926.17 KII70916.1 - 0.00077 19.6 0.6 0.017 15.2 0.3 2.1 1 1 1 2 2 2 2 THUMP domain DDE_3 PF13358.6 KII70917.1 - 6.3e-08 32.5 0.0 6.9e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII70918.1 - 6.6e-13 48.1 0.4 1e-08 34.7 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 KII70918.1 - 7.7e-09 34.8 1.5 4.7e-07 29.1 0.1 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 PAX PF00292.18 KII70918.1 - 4.5e-08 33.1 0.2 5.5e-08 32.8 0.2 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 KII70918.1 - 4.4e-07 30.4 0.7 0.00026 21.6 0.0 2.1 1 1 1 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.6 KII70918.1 - 1.8e-06 27.9 0.2 4.9e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 KII70918.1 - 2e-06 28.0 0.1 3.1e-06 27.4 0.1 1.4 1 1 0 1 1 1 1 Transposase HTH_38 PF13936.6 KII70918.1 - 6.7e-06 25.8 1.3 2.1e-05 24.2 0.8 2.0 2 1 0 2 2 2 1 Helix-turn-helix domain DUF1323 PF07037.11 KII70918.1 - 8.1e-06 26.2 0.3 1.5e-05 25.3 0.3 1.6 1 1 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_29 PF13551.6 KII70918.1 - 8.5e-06 25.7 0.1 0.00029 20.8 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn helix Bot1p PF12298.8 KII70918.1 - 9.9e-06 25.8 1.0 1.3e-05 25.5 1.0 1.0 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein CENP-B_N PF04218.13 KII70918.1 - 1.3e-05 24.8 0.9 5.1e-05 22.8 0.1 2.2 2 1 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_33 PF13592.6 KII70918.1 - 1.7e-05 24.4 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII70918.1 - 0.00044 20.4 0.9 0.0019 18.4 0.0 2.2 2 1 0 2 2 2 1 Transposase HTH_3 PF01381.22 KII70918.1 - 0.0014 18.6 0.0 0.023 14.8 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix HTH_24 PF13412.6 KII70918.1 - 0.0044 16.5 2.0 0.49 10.0 0.1 2.9 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_7 PF02796.15 KII70918.1 - 0.0048 16.9 1.7 0.26 11.4 0.3 2.6 2 2 0 2 2 2 1 Helix-turn-helix domain of resolvase TrmB PF01978.19 KII70918.1 - 0.0061 16.4 0.1 0.053 13.4 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MSP1a PF11670.8 KII70918.1 - 0.0085 15.4 0.0 0.014 14.7 0.0 1.3 1 1 0 1 1 1 1 Major surface protein 1a (MSP1a) HTH_Tnp_IS630 PF01710.16 KII70918.1 - 0.0089 16.1 1.5 0.034 14.2 1.5 1.8 1 1 0 1 1 1 1 Transposase TnsD PF15978.5 KII70918.1 - 0.0091 15.0 1.0 0.037 13.0 0.4 1.8 1 1 1 2 2 2 1 Tn7-like transposition protein D LacI PF00356.21 KII70918.1 - 0.013 15.3 1.2 11 5.9 0.0 3.6 3 1 1 4 4 4 0 Bacterial regulatory proteins, lacI family HTH_40 PF14493.6 KII70918.1 - 0.016 15.7 0.0 0.029 14.8 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain SpoIIID PF12116.8 KII70918.1 - 0.019 15.0 1.2 0.34 11.0 1.1 2.3 1 1 0 1 1 1 0 Stage III sporulation protein D YdaS_antitoxin PF15943.5 KII70918.1 - 0.024 14.5 0.2 9.7 6.1 0.1 2.5 3 0 0 3 3 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Tn7_Tnp_TnsA_C PF08721.11 KII70918.1 - 0.029 15.0 0.0 4.7 7.9 0.0 2.4 2 1 0 2 2 2 0 TnsA endonuclease C terminal HTH_Tnp_1_2 PF13022.6 KII70918.1 - 0.031 14.4 0.5 0.1 12.7 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase Arg_repressor PF01316.21 KII70918.1 - 0.038 13.7 1.3 0.065 13.0 0.1 1.9 2 1 0 2 2 2 0 Arginine repressor, DNA binding domain Sigma70_r4_2 PF08281.12 KII70918.1 - 0.039 13.6 0.0 0.34 10.6 0.0 2.2 2 1 0 2 2 2 0 Sigma-70, region 4 HTH_DeoR PF08220.12 KII70918.1 - 0.041 13.6 1.0 0.23 11.2 0.1 2.3 2 1 0 2 2 2 0 DeoR-like helix-turn-helix domain KORA PF16509.5 KII70918.1 - 0.043 14.1 1.2 0.059 13.7 0.3 1.6 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor Sigma70_r4 PF04545.16 KII70918.1 - 0.045 13.3 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_11 PF08279.12 KII70918.1 - 0.067 13.2 1.1 0.17 11.8 0.0 2.2 3 0 0 3 3 2 0 HTH domain HTH_37 PF13744.6 KII70918.1 - 0.091 12.7 0.3 1.8 8.6 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_17 PF12728.7 KII70918.1 - 0.12 12.5 0.0 4.7 7.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Sld5 PF05916.11 KII70919.1 - 0.0078 16.7 0.0 0.014 15.8 0.0 1.5 1 1 0 1 1 1 1 GINS complex protein Olfactory_mark PF06554.12 KII70919.1 - 0.054 13.2 0.3 0.089 12.5 0.3 1.3 1 0 0 1 1 1 0 Olfactory marker protein fn3 PF00041.21 KII70921.1 - 0.018 15.4 0.1 2.3 8.6 0.0 2.9 3 0 0 3 3 3 0 Fibronectin type III domain DDE_3 PF13358.6 KII70923.1 - 8.6e-05 22.3 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease MF_alpha PF04648.12 KII70925.1 - 0.88 10.0 7.4 89 3.6 0.2 4.6 3 0 0 3 3 3 0 Yeast mating factor alpha hormone Sugar_tr PF00083.24 KII70927.1 - 2.7e-05 23.2 0.5 2.7e-05 23.2 0.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII70927.1 - 0.00016 20.7 4.1 0.00018 20.6 4.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Tmemb_18A PF09771.9 KII70927.1 - 0.09 13.2 2.6 1.3 9.5 0.1 2.1 1 1 1 2 2 2 0 Transmembrane protein 188 MULE PF10551.9 KII70929.1 - 9.6e-07 29.1 0.2 2.5e-06 27.8 0.2 1.7 1 0 0 1 1 1 1 MULE transposase domain Peptidase_C50 PF03568.17 KII70930.1 - 4.9e-49 167.5 0.0 5.9e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 KII70930.1 - 0.048 13.1 0.0 0.073 12.5 0.0 1.3 1 0 0 1 1 1 0 CHAT domain Peptidase_C50 PF03568.17 KII70931.1 - 1.3e-07 31.1 0.2 5.9e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase family C50 Phage_F PF02305.17 KII70933.1 - 0.1 11.3 0.1 0.13 11.0 0.1 1.0 1 0 0 1 1 1 0 Capsid protein (F protein) Sec62 PF03839.16 KII70936.1 - 0.016 14.7 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 N1221 PF07923.13 KII70937.1 - 0.073 12.2 0.1 0.083 12.1 0.1 1.1 1 0 0 1 1 1 0 N1221-like protein 6PGD PF00393.19 KII70939.1 - 3.2e-81 272.9 0.2 4.1e-81 272.6 0.2 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KII70939.1 - 4.7e-31 108.1 0.0 7.9e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KII70939.1 - 0.16 12.2 0.0 0.96 9.7 0.0 2.1 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase WD40 PF00400.32 KII70940.1 - 3.7e-06 27.6 4.5 0.00061 20.6 1.2 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII70940.1 - 0.023 15.0 0.4 0.047 14.0 0.3 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain 6PGD PF00393.19 KII70942.1 - 4.5e-81 272.4 0.2 5.8e-81 272.0 0.2 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KII70942.1 - 7e-49 166.0 0.0 1e-48 165.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 KII70942.1 - 4.6e-05 23.5 0.1 0.00011 22.2 0.1 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 KII70942.1 - 0.0019 18.8 0.0 0.0038 17.8 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PGK PF00162.19 KII70942.1 - 0.16 10.9 0.0 0.37 9.7 0.0 1.5 2 0 0 2 2 2 0 Phosphoglycerate kinase 2-Hacid_dh_C PF02826.19 KII70942.1 - 0.19 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 KII70942.1 - 0.21 11.8 0.0 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase EMP24_GP25L PF01105.24 KII70943.1 - 0.076 13.0 0.4 0.18 11.7 0.4 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD EssA PF10661.9 KII70943.1 - 0.087 12.7 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA DUF3290 PF11694.8 KII70943.1 - 0.18 11.8 0.4 0.34 10.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) Vezatin PF12632.7 KII70943.1 - 0.21 10.9 0.3 0.3 10.4 0.3 1.2 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes DUF4381 PF14316.6 KII70943.1 - 0.21 11.8 0.4 0.4 10.9 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Mucin PF01456.17 KII70943.1 - 1.7 8.6 6.3 0.19 11.7 0.2 2.1 2 1 0 2 2 2 0 Mucin-like glycoprotein EMC1_C PF07774.13 KII70946.1 - 1.8e-16 60.5 1.4 5.2e-16 59.0 1.4 1.8 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal HTH_56 PF18662.1 KII70946.1 - 0.061 13.4 1.9 0.73 9.9 0.2 2.5 2 0 0 2 2 2 0 Cch helix turn helix domain Forkhead PF00250.18 KII70947.1 - 3.1e-27 94.7 0.2 3.1e-27 94.7 0.2 3.2 4 1 0 4 4 4 1 Forkhead domain DDE_3 PF13358.6 KII70948.1 - 1.2e-18 67.3 0.0 2.5e-18 66.2 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII70948.1 - 0.15 11.7 0.0 0.38 10.4 0.0 1.7 1 1 1 2 2 2 0 Winged helix-turn helix DnaJ PF00226.31 KII70950.1 - 1.2e-12 47.7 0.2 1.2e-12 47.7 0.2 2.3 2 0 0 2 2 2 1 DnaJ domain MCU PF04678.13 KII70951.1 - 1.1e-35 123.4 3.8 1.3e-35 123.1 3.8 1.0 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Sigma_reg_C PF13791.6 KII70951.1 - 0.038 14.2 1.1 0.038 14.2 1.1 1.9 2 0 0 2 2 2 0 Sigma factor regulator C-terminal Myc-LZ PF02344.15 KII70951.1 - 0.14 12.3 0.3 0.29 11.3 0.3 1.6 1 0 0 1 1 1 0 Myc leucine zipper domain Tetraspanin PF00335.20 KII70954.1 - 5.2e-14 52.5 14.8 8.2e-14 51.9 14.8 1.3 1 0 0 1 1 1 1 Tetraspanin family DUF3402 PF11882.8 KII70954.1 - 0.092 11.8 0.2 0.14 11.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) DUF4481 PF14800.6 KII70954.1 - 0.21 11.0 7.5 0.32 10.4 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) rve PF00665.26 KII70955.1 - 2.1e-20 73.1 0.1 3.1e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII70955.1 - 5.3e-07 29.6 0.9 2.2e-06 27.7 0.6 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII70955.1 - 1.1e-05 25.1 0.0 2.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII70955.1 - 0.00092 19.4 0.1 0.0017 18.6 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger DDE_3 PF13358.6 KII70955.1 - 0.0025 17.6 0.1 0.0043 16.8 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Nepo_coat_N PF03689.15 KII70955.1 - 0.014 15.4 0.1 0.11 12.4 0.0 2.3 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain DUF3886 PF13025.6 KII70956.1 - 0.024 14.8 3.2 0.03 14.5 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Phage_Gp23 PF10669.9 KII70956.1 - 0.078 13.3 0.1 0.13 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) E1-E2_ATPase PF00122.20 KII70956.1 - 0.13 11.8 2.8 0.2 11.2 2.8 1.3 1 0 0 1 1 1 0 E1-E2 ATPase DUF2062 PF09835.9 KII70956.1 - 0.34 10.7 7.1 1.4 8.8 1.8 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2062) Ndc1_Nup PF09531.10 KII70956.1 - 0.92 8.1 4.7 1.2 7.8 4.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MFS_1 PF07690.16 KII70956.1 - 1.2 7.9 15.2 2.5 7.0 15.4 1.5 1 1 0 1 1 1 0 Major Facilitator Superfamily Sigma_reg_N PF13800.6 KII70956.1 - 2 8.7 0.0 2 8.7 0.0 2.6 2 1 1 3 3 3 0 Sigma factor regulator N-terminal Wzy_C PF04932.15 KII70956.1 - 3.6 7.2 7.8 13 5.4 7.8 1.8 1 1 0 1 1 1 0 O-Antigen ligase Bystin PF05291.11 KII70957.1 - 6.4e-29 101.2 2.2 7.1e-29 101.0 2.2 1.0 1 0 0 1 1 1 1 Bystin Bystin PF05291.11 KII70958.1 - 4.8e-20 72.0 1.8 1e-19 71.0 0.0 1.9 2 0 0 2 2 2 1 Bystin Sec62 PF03839.16 KII70958.1 - 5.3 6.5 8.1 7.4 6.0 8.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Hexokinase_2 PF03727.16 KII70959.1 - 9.5e-45 152.9 0.7 2.1e-42 145.2 0.2 2.4 2 1 0 2 2 2 1 Hexokinase Hexokinase_1 PF00349.21 KII70959.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Hexokinase RNA_pol_Rpb1_6 PF04992.14 KII70959.1 - 0.027 14.3 0.1 0.05 13.4 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 FancD2 PF14631.6 KII70960.1 - 5.2e-12 44.1 5.1 5.6e-12 44.0 5.1 1.0 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease SQHop_cyclase_C PF13243.6 KII70961.1 - 0.18 10.9 0.0 0.22 10.6 0.0 1.1 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain zf-CCHC PF00098.23 KII70963.1 - 4.5e-05 23.3 2.9 6.7e-05 22.8 2.9 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 KII70963.1 - 0.027 14.2 2.8 0.045 13.5 2.8 1.3 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger UCH PF00443.29 KII70965.1 - 2.4e-38 132.1 0.1 3.6e-38 131.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KII70965.1 - 1.1e-13 51.3 1.6 1.3e-12 47.8 0.1 2.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 KII70965.1 - 8.6e-13 47.9 0.0 5.1e-07 29.5 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP_var PF17807.1 KII70965.1 - 6.8e-10 38.6 3.2 5.4e-09 35.7 0.8 2.5 2 0 0 2 2 2 1 Variant UBP zinc finger UCH_1 PF13423.6 KII70965.1 - 2.2e-06 27.5 0.1 3.1e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase HAD_2 PF13419.6 KII70967.1 - 0.084 12.9 0.8 0.13 12.4 0.7 1.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase GramPos_pilinD3 PF16570.5 KII70967.1 - 0.13 13.0 0.4 0.25 12.0 0.4 1.4 1 0 0 1 1 1 0 Gram-positive pilin backbone subunit 3, Cna-B-like domain MULE PF10551.9 KII70968.1 - 1.1e-06 28.9 0.0 2.3e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain LMP PF04778.12 KII70968.1 - 0.082 12.8 0.3 0.12 12.3 0.3 1.2 1 0 0 1 1 1 0 LMP repeated region DDE_Tnp_IS1595 PF12762.7 KII70969.1 - 6.6e-13 48.9 0.1 1.7e-11 44.4 0.1 2.1 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII70970.1 - 1.4e-14 54.4 0.0 1.7e-14 54.1 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII70971.1 - 3.4e-11 43.1 0.0 5.3e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease CRIC_ras_sig PF10534.9 KII70971.1 - 0.032 14.4 0.1 0.1 12.8 0.0 1.9 2 1 1 3 3 3 0 Connector enhancer of kinase suppressor of ras RNA_pol_Rpc34 PF05158.12 KII70973.1 - 7.8e-20 71.5 0.0 1.1e-19 71.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.11 KII70973.1 - 0.025 15.3 0.0 6.2 7.5 0.0 2.7 3 0 0 3 3 3 0 Replication protein A C terminal Papo_T_antigen PF02380.15 KII70976.1 - 0.062 13.4 0.1 0.087 13.0 0.1 1.2 1 0 0 1 1 1 0 T-antigen specific domain Pkinase PF00069.25 KII70979.1 - 1.6e-32 112.9 0.0 4.5e-32 111.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII70979.1 - 6.1e-16 58.5 0.0 9.4e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ER_lumen_recept PF00810.18 KII70980.1 - 7.5e-51 172.8 12.9 7.5e-51 172.8 12.9 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 KII70980.1 - 0.0034 17.1 1.8 0.0034 17.1 1.8 3.7 3 1 1 4 4 4 2 PQ loop repeat Hemocyanin_M PF00372.19 KII70981.1 - 0.041 13.1 0.0 0.046 12.9 0.0 1.3 1 1 0 1 1 1 0 Hemocyanin, copper containing domain Phage_BR0599 PF09356.10 KII70981.1 - 0.048 14.0 0.0 0.061 13.7 0.0 1.2 1 0 0 1 1 1 0 Phage conserved hypothetical protein BR0599 NTP_transferase PF00483.23 KII70984.1 - 2e-35 122.6 0.0 2.8e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KII70984.1 - 9.5e-08 32.6 0.0 2.3e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 KII70984.1 - 0.095 12.6 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Cytidylyltransferase CTP_transf_3 PF02348.19 KII70985.1 - 7.3e-15 55.5 0.0 8.8e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase PAPS_reduct PF01507.19 KII70986.1 - 0.0046 17.0 0.0 0.0065 16.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.20 KII70986.1 - 0.2 11.4 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 PP-loop family MAF_flag10 PF01973.18 KII70987.1 - 4.1e-30 104.7 0.1 8.8e-30 103.6 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF115 Ldl_recept_a PF00057.18 KII70988.1 - 7.5e-08 32.5 12.2 7.5e-08 32.5 12.2 2.2 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII70989.1 - 7.3e-10 39.4 0.3 1.1e-09 38.9 0.3 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII70989.1 - 3.5e-05 22.8 0.0 5.7e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII70989.1 - 0.05 13.6 3.5 5.3 7.5 0.7 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat OATP PF03137.20 KII70991.1 - 3.7e-58 197.2 26.5 7.7e-58 196.1 26.5 1.5 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KII70991.1 - 4e-13 49.0 10.0 4e-13 49.0 10.0 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 KII70991.1 - 0.0088 16.2 7.5 0.0088 16.2 7.5 2.1 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain TMEM89 PF15098.6 KII70991.1 - 0.078 13.2 0.0 18 5.5 0.0 2.5 2 0 0 2 2 2 0 TMEM89 protein family Sulf_transp PF04143.14 KII70991.1 - 0.57 9.7 9.7 0.045 13.3 4.6 1.8 2 0 0 2 2 2 0 Sulphur transport DUF2781 PF10914.8 KII70991.1 - 6.8 7.1 11.6 5.6 7.4 4.6 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2781) Insulin_TMD PF17870.1 KII70992.1 - 0.004 17.2 0.1 0.0073 16.3 0.1 1.4 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment DUF3278 PF11683.8 KII70992.1 - 0.0062 16.6 1.6 0.0082 16.2 1.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3278) DUF63 PF01889.17 KII70992.1 - 0.0081 16.4 3.1 0.0091 16.2 3.1 1.1 1 0 0 1 1 1 1 Membrane protein of unknown function DUF63 ETRAMP PF09716.10 KII70992.1 - 0.016 15.3 0.3 0.033 14.3 0.3 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2448 PF10476.9 KII70992.1 - 0.061 13.2 0.0 0.068 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) Sigma_reg_N PF13800.6 KII70992.1 - 1.4 9.3 6.1 0.82 10.0 1.6 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal FeoB_associated PF12669.7 KII70992.1 - 3.3 8.2 5.4 12 6.4 5.4 1.9 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein NIF PF03031.18 KII70995.1 - 0.1 12.4 0.5 0.47 10.2 0.0 1.9 1 1 1 2 2 2 0 NLI interacting factor-like phosphatase Sortilin_C PF15901.5 KII70996.1 - 6e-15 56.0 3.3 6e-15 56.0 3.3 2.3 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII70996.1 - 3e-07 29.6 0.1 0.0024 16.7 0.0 2.3 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII70996.1 - 2e-05 24.7 12.8 2e-05 24.7 12.8 3.4 4 1 1 5 5 5 1 Low-density lipoprotein receptor domain class A HTH_Crp_2 PF13545.6 KII70998.1 - 0.039 13.9 0.1 0.056 13.4 0.1 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Ldl_recept_a PF00057.18 KII70999.1 - 2.5e-07 30.8 14.2 2.5e-07 30.8 14.2 3.0 3 1 1 4 4 4 1 Low-density lipoprotein receptor domain class A rve PF00665.26 KII71001.1 - 7.3e-07 29.4 0.0 1.4e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII71001.1 - 2.9e-05 23.8 0.0 6.4e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII71001.1 - 0.0074 16.4 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Vasohibin PF14822.6 KII71002.1 - 0.031 13.5 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 Vasohibin SNAP PF14938.6 KII71004.1 - 3.3e-07 30.0 0.7 1.6e-06 27.8 0.1 2.0 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP GGDEF_2 PF17853.1 KII71004.1 - 0.024 14.9 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 GGDEF-like domain TPR_6 PF13174.6 KII71004.1 - 0.055 14.1 0.3 3.7 8.4 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3562 PF12085.8 KII71009.1 - 0.1 12.2 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3562) Annexin PF00191.20 KII71012.1 - 0.0088 16.1 0.1 0.032 14.3 0.1 1.9 2 0 0 2 2 2 1 Annexin Fimbrial PF00419.20 KII71013.1 - 2.1e-20 73.6 8.5 3.1e-20 73.0 8.5 1.2 1 0 0 1 1 1 1 Fimbrial protein OEP PF02321.18 KII71014.1 - 8.5e-56 188.7 35.2 6.1e-29 101.2 11.8 2.0 2 0 0 2 2 2 2 Outer membrane efflux protein DisA-linker PF10635.9 KII71014.1 - 0.094 12.5 0.2 0.094 12.5 0.2 2.5 2 1 0 2 2 2 0 DisA bacterial checkpoint controller linker region Se-cys_synth_N PF12390.8 KII71014.1 - 0.55 10.5 2.2 0.57 10.4 0.4 2.0 2 0 0 2 2 2 0 Selenocysteine synthase N terminal Sortilin_C PF15901.5 KII71015.1 - 3.5e-10 40.5 8.7 3.5e-10 40.5 8.7 2.4 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Ldl_recept_a PF00057.18 KII71015.1 - 1.8e-09 37.6 11.2 1.8e-09 37.6 11.2 3.4 2 1 1 3 3 3 1 Low-density lipoprotein receptor domain class A Shugoshin_C PF07557.11 KII71019.1 - 0.016 15.0 0.1 0.027 14.3 0.1 1.4 1 0 0 1 1 1 0 Shugoshin C terminus rve PF00665.26 KII71020.1 - 6.1e-16 58.7 0.0 7e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII71020.1 - 0.029 14.1 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS1595 PF12762.7 KII71021.1 - 1.1e-05 25.5 0.0 1.9e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain Elongin_A PF06881.11 KII71021.1 - 0.24 11.9 1.7 7.4 7.2 0.7 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A rve PF00665.26 KII71023.1 - 1.4e-11 44.6 0.0 5.2e-11 42.8 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 KII71023.1 - 3.8e-08 33.6 0.1 7.9e-07 29.3 0.1 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71023.1 - 6.9e-07 29.2 0.1 5.5e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Asp_protease_2 PF13650.6 KII71023.1 - 3.6e-06 27.5 0.0 6e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 KII71023.1 - 6.3e-05 23.5 0.0 0.00043 20.8 0.0 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Integrase_H2C2 PF17921.1 KII71023.1 - 0.00097 19.2 0.1 0.0045 17.1 0.0 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain FNIP_M PF14637.6 KII71024.1 - 0.086 12.8 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain bZIP_1 PF00170.21 KII71025.1 - 2.1e-06 27.7 3.9 3.5e-06 27.0 3.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KII71025.1 - 0.00075 19.5 6.6 0.0015 18.5 6.6 1.4 1 0 0 1 1 1 1 Basic region leucine zipper TRF PF08558.10 KII71025.1 - 0.054 13.1 0.0 0.062 12.9 0.0 1.1 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) YARHG PF13308.6 KII71025.1 - 0.065 13.1 2.2 0.12 12.3 1.3 1.9 2 1 0 2 2 2 0 YARHG domain DUF4315 PF14193.6 KII71025.1 - 0.21 11.6 2.9 0.34 10.9 2.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4315) DUF1029 PF06269.12 KII71026.1 - 0.14 12.3 6.2 0.39 10.9 6.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1029) Cytochrom_B561 PF03188.16 KII71027.1 - 0.042 14.0 10.6 0.017 15.3 5.2 2.0 1 1 1 2 2 2 0 Eukaryotic cytochrome b561 DUF716 PF04819.12 KII71027.1 - 0.67 9.6 8.9 0.09 12.4 4.0 1.9 1 1 0 2 2 2 0 Family of unknown function (DUF716) zf-Sec23_Sec24 PF04810.15 KII71029.1 - 0.14 12.2 0.4 0.14 12.2 0.4 2.1 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-A20 PF01754.16 KII71029.1 - 0.16 11.9 5.8 0.56 10.2 1.0 2.4 2 0 0 2 2 2 0 A20-like zinc finger DDE_3 PF13358.6 KII71030.1 - 6.7e-11 42.1 0.3 6.9e-11 42.1 0.3 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Activin_recp PF01064.23 KII71031.1 - 7.9e-06 26.9 13.6 1e-05 26.5 13.6 1.1 1 0 0 1 1 1 1 Activin types I and II receptor domain Toxin_TOLIP PF00087.21 KII71031.1 - 0.37 11.1 14.5 3.4 8.0 14.5 2.0 1 1 0 1 1 1 0 Snake toxin and toxin-like protein Hexokinase_1 PF00349.21 KII71034.1 - 2.1e-13 50.6 0.0 2.4e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 KII71035.1 - 1.8e-61 207.6 0.0 2.2e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII71035.1 - 7.5e-21 74.9 0.0 1.2e-20 74.3 0.0 1.3 1 0 0 1 1 1 1 Hexokinase WD40 PF00400.32 KII71037.1 - 0.0017 19.2 0.0 0.19 12.6 0.0 2.4 2 1 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII71037.1 - 0.011 16.1 0.0 0.015 15.6 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain MoaE PF02391.17 KII71038.1 - 7.6e-25 87.4 0.1 8.6e-25 87.2 0.1 1.0 1 0 0 1 1 1 1 MoaE protein wnt PF00110.19 KII71039.1 - 0.19 11.3 0.0 0.22 11.1 0.0 1.0 1 0 0 1 1 1 0 wnt family DUF1304 PF06993.12 KII71042.1 - 0.13 12.2 0.1 0.17 11.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1304) FG-GAP PF01839.23 KII71044.1 - 3.5e-10 39.8 4.2 6e-05 23.1 3.4 2.4 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.6 KII71044.1 - 1.4e-08 35.2 1.2 4.3e-08 33.6 0.8 2.1 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF4113 PF13438.6 KII71045.1 - 9.4e-22 76.9 0.0 2.3e-21 75.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4113) IMS_C PF11799.8 KII71045.1 - 9.9e-10 39.2 0.0 1.8e-09 38.3 0.0 1.4 1 1 0 1 1 1 1 impB/mucB/samB family C-terminal domain DUF4143 PF13635.6 KII71046.1 - 0.053 13.7 0.1 0.66 10.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4143) Tox-PL-2 PF15643.6 KII71049.1 - 0.18 11.9 0.0 0.24 11.5 0.0 1.2 1 0 0 1 1 1 0 Papain fold toxin 2 Glyco_transf_10 PF00852.19 KII71050.1 - 1.1e-38 132.8 0.9 1.9e-38 132.0 0.9 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 KII71050.1 - 0.0061 17.0 0.2 0.023 15.2 0.2 2.0 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal TGF_beta PF00019.20 KII71052.1 - 3.1e-19 69.9 1.2 3.9e-19 69.6 1.2 1.1 1 0 0 1 1 1 1 Transforming growth factor beta like domain Prok-RING_4 PF14447.6 KII71053.1 - 0.091 12.6 7.4 0.15 12.0 7.4 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KII71053.1 - 0.25 11.2 8.9 0.71 9.8 8.9 1.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KII71053.1 - 1.9 8.5 10.4 3.3 7.8 10.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain EMP24_GP25L PF01105.24 KII71054.1 - 6.8e-16 58.7 0.4 9.2e-16 58.3 0.0 1.3 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD Kunitz_BPTI PF00014.23 KII71055.1 - 8.8e-06 25.9 8.6 1.3e-05 25.3 8.6 1.3 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain GCFC PF07842.12 KII71056.1 - 3.9e-15 56.2 5.9 6.5e-08 32.5 0.1 3.5 2 1 1 3 3 3 2 GC-rich sequence DNA-binding factor-like protein EspA PF03433.13 KII71057.1 - 0.054 13.3 0.2 0.054 13.3 0.2 2.0 3 0 0 3 3 3 0 EspA-like secreted protein LacI PF00356.21 KII71058.1 - 0.0013 18.4 0.0 0.0024 17.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_Tnp_Tc5 PF03221.16 KII71058.1 - 0.0015 18.5 0.4 0.0025 17.8 0.4 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_3 PF01381.22 KII71058.1 - 0.0026 17.8 0.2 0.0047 16.9 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix CENP-B_N PF04218.13 KII71058.1 - 0.0066 16.0 0.1 0.034 13.8 0.1 2.3 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.6 KII71058.1 - 0.014 15.1 0.1 0.035 13.9 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_IclR PF09339.10 KII71058.1 - 0.028 14.2 0.1 0.06 13.1 0.0 1.6 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_23 PF13384.6 KII71058.1 - 0.03 14.1 0.0 0.086 12.7 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain HTH_psq PF05225.16 KII71058.1 - 0.038 13.7 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_28 PF13518.6 KII71058.1 - 0.051 13.7 1.0 0.12 12.5 0.2 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain TrmB PF01978.19 KII71058.1 - 0.058 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 KII71058.1 - 0.069 13.1 0.1 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_36 PF13730.6 KII71058.1 - 0.078 12.9 0.2 0.2 11.6 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain 7tm_1 PF00001.21 KII71059.1 - 2.5e-16 59.8 17.2 3.4e-16 59.4 17.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Glucosamine_iso PF01182.20 KII71061.1 - 2.5e-46 158.4 0.0 3.3e-46 158.0 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase COE1_DBD PF16422.5 KII71062.1 - 2.4e-41 141.7 0.1 3.2e-41 141.3 0.1 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain DUF440 PF04269.12 KII71062.1 - 0.13 12.6 0.1 0.29 11.5 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF440 Spore-coat_CotD PF11122.8 KII71063.1 - 0.13 13.0 0.1 0.17 12.7 0.1 1.4 1 1 0 1 1 1 0 Inner spore coat protein D Peptidase_M16_C PF05193.21 KII71064.1 - 1.3e-11 44.9 0.0 3.6e-11 43.4 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KII71064.1 - 1.1e-10 41.7 0.0 1.9e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Metallophos PF00149.28 KII71065.1 - 9.2e-37 127.5 0.6 1.6e-36 126.8 0.4 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KII71065.1 - 0.029 14.8 0.1 0.057 13.9 0.1 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 KII71065.1 - 0.12 12.6 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Y_Y_Y PF07495.13 KII71067.1 - 0.14 12.2 0.1 0.65 10.0 0.0 2.1 2 0 0 2 2 2 0 Y_Y_Y domain zf-C2H2 PF00096.26 KII71067.1 - 0.17 12.4 0.5 0.92 10.1 0.5 2.3 1 1 0 1 1 1 0 Zinc finger, C2H2 type Glyco_transf_10 PF00852.19 KII71068.1 - 4.1e-31 108.1 2.0 5.2e-31 107.7 2.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term KaiA PF07688.12 KII71068.1 - 0.072 13.2 1.1 4.9 7.3 0.1 2.6 2 1 1 3 3 3 0 KaiA C-terminal domain adh_short PF00106.25 KII71069.1 - 9.5e-21 74.1 0.1 1.2e-20 73.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII71069.1 - 9.4e-15 54.8 0.0 1.1e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII71069.1 - 1.6e-07 31.4 0.0 1.8e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KII71069.1 - 0.0015 18.0 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 KII71069.1 - 0.0037 16.6 0.1 0.0072 15.7 0.1 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 KII71069.1 - 0.0086 16.0 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TusA PF01206.17 KII71069.1 - 0.14 12.0 0.0 23 4.9 0.1 2.4 2 0 0 2 2 2 0 Sulfurtransferase TusA adh_short PF00106.25 KII71070.1 - 0.0054 16.2 0.0 0.0088 15.5 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase HH_signal PF01085.18 KII71070.1 - 0.064 12.9 0.0 0.079 12.6 0.0 1.1 1 0 0 1 1 1 0 Hedgehog amino-terminal signalling domain RVT_1 PF00078.27 KII71072.1 - 7.6e-08 32.1 0.0 2.2e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CBM_10 PF02013.16 KII71072.1 - 0.13 12.8 0.2 0.25 11.9 0.2 1.5 1 0 0 1 1 1 0 Cellulose or protein binding domain PduV-EutP PF10662.9 KII71074.1 - 0.098 12.4 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation PSI_integrin PF17205.3 KII71076.1 - 0.022 14.5 1.2 0.028 14.2 1.2 1.3 1 0 0 1 1 1 0 Integrin plexin domain PSI PF01437.25 KII71076.1 - 0.057 14.0 3.4 0.081 13.5 3.4 1.4 1 1 0 1 1 1 0 Plexin repeat Integrin_beta PF00362.18 KII71077.1 - 1.6e-05 24.7 0.0 2e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain TssR PF17643.1 KII71077.1 - 0.0045 15.0 0.1 0.0054 14.7 0.1 1.0 1 0 0 1 1 1 1 Type VI secretion system, TssR VWA PF00092.28 KII71077.1 - 0.0065 16.7 0.1 0.0075 16.5 0.1 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Anp1 PF03452.14 KII71077.1 - 0.022 14.2 0.1 0.024 14.1 0.1 1.1 1 0 0 1 1 1 0 Anp1 Imm57 PF15596.6 KII71078.1 - 0.081 13.3 0.1 0.19 12.0 0.1 1.6 1 0 0 1 1 1 0 Immunity protein 57 UNC-79 PF14776.6 KII71079.1 - 0.0081 15.0 2.5 0.011 14.5 2.0 1.4 1 1 0 1 1 1 1 Cation-channel complex subunit UNC-79 CxC5 PF18718.1 KII71080.1 - 0.024 14.7 0.1 0.048 13.7 0.1 1.6 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases DUF5617 PF18493.1 KII71081.1 - 0.09 12.9 0.0 0.41 10.8 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) Pkinase PF00069.25 KII71083.1 - 1.2e-09 37.9 1.3 4.1e-08 32.9 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain FTA2 PF13095.6 KII71083.1 - 0.071 12.7 0.0 0.17 11.5 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EIF_2_alpha PF07541.12 KII71085.1 - 2.3e-28 98.6 0.0 3.5e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit KIND PF16474.5 KII71085.1 - 0.062 13.2 0.9 0.095 12.6 0.9 1.3 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain FtsJ PF01728.19 KII71086.1 - 5.3e-51 173.2 0.1 5.9e-51 173.1 0.1 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 KII71086.1 - 0.035 13.8 0.0 0.06 13.0 0.0 1.6 1 1 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 KII71086.1 - 0.056 14.2 0.0 0.11 13.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 KII71086.1 - 0.13 11.6 0.1 0.31 10.3 0.1 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KII71086.1 - 0.19 11.5 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Tmemb_18A PF09771.9 KII71089.1 - 0.016 15.6 0.1 0.042 14.2 0.1 1.7 1 0 0 1 1 1 0 Transmembrane protein 188 RcsD_ABL PF16359.5 KII71090.1 - 0.024 14.8 0.1 0.9 9.7 0.0 2.4 2 0 0 2 2 2 0 RcsD-ABL domain N_formyltrans_C PF18216.1 KII71090.1 - 0.11 12.2 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 N-formyltransferase dimerization C-terminal domain ADK_lid PF05191.14 KII71092.1 - 0.0048 16.8 0.5 0.011 15.7 0.5 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid tRNA_synt_2f PF02092.17 KII71092.1 - 0.038 12.9 0.0 0.048 12.6 0.0 1.1 1 0 0 1 1 1 0 Glycyl-tRNA synthetase beta subunit Zn-ribbon_8 PF09723.10 KII71092.1 - 0.13 12.4 1.5 0.39 10.9 1.4 1.9 1 1 0 1 1 1 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 KII71092.1 - 0.86 9.4 5.2 11 5.9 5.2 2.2 1 1 0 1 1 1 0 Rubredoxin metal binding domain RT_RNaseH_2 PF17919.1 KII71093.1 - 2.3e-11 43.6 0.0 3.3e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71093.1 - 0.0077 16.5 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71094.1 - 3.4e-08 33.7 0.3 9.8e-08 32.2 0.1 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71094.1 - 0.025 14.6 0.1 0.058 13.4 0.1 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Ras PF00071.22 KII71095.1 - 9.9e-57 191.1 0.4 1.2e-56 190.8 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII71095.1 - 4e-32 110.9 1.0 5.6e-32 110.5 0.3 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII71095.1 - 2.3e-14 53.2 0.4 2.8e-14 52.9 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KII71095.1 - 1.3e-05 25.2 0.1 2.3e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KII71095.1 - 0.00081 19.0 0.2 0.004 16.7 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KII71095.1 - 0.0013 18.7 0.6 0.04 13.8 0.0 2.3 2 1 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 KII71095.1 - 0.0013 18.1 0.3 0.0016 17.8 0.3 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KII71095.1 - 0.0014 18.1 0.1 0.0024 17.3 0.1 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 KII71095.1 - 0.0039 16.9 0.1 0.0071 16.1 0.1 1.6 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation MCM PF00493.23 KII71095.1 - 0.0069 15.5 0.0 0.026 13.6 0.0 1.9 2 0 0 2 2 2 1 MCM P-loop domain AAA_22 PF13401.6 KII71095.1 - 0.0078 16.5 0.2 0.086 13.1 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KII71095.1 - 0.012 16.0 0.0 0.019 15.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 KII71095.1 - 0.013 15.0 0.0 0.032 13.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 KII71095.1 - 0.023 15.2 0.8 0.036 14.6 0.8 1.8 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 KII71095.1 - 0.029 13.8 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_32 PF13654.6 KII71095.1 - 0.032 13.0 0.1 11 4.7 0.0 2.7 2 1 1 3 3 3 0 AAA domain AAA_24 PF13479.6 KII71095.1 - 0.037 13.8 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 KII71095.1 - 0.047 12.9 2.1 1.8 7.6 0.1 2.7 1 1 1 2 2 2 0 G-protein alpha subunit AAA_29 PF13555.6 KII71095.1 - 0.051 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 KII71095.1 - 0.058 13.8 0.1 0.2 12.1 0.0 2.0 1 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KII71095.1 - 0.093 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IFT81_CH PF18383.1 KII71096.1 - 0.036 14.3 0.2 0.21 11.9 0.0 2.4 2 1 1 3 3 3 0 Intraflagellar transport 81 calponin homology domain Asp_protease_2 PF13650.6 KII71096.1 - 0.11 13.1 0.1 0.41 11.3 0.0 2.0 2 0 0 2 2 2 0 Aspartyl protease BLI1 PF17324.2 KII71097.1 - 0.00036 21.2 0.9 0.00047 20.8 0.9 1.1 1 0 0 1 1 1 1 BLOC-1 interactor 1 RVP PF00077.20 KII71098.1 - 0.039 14.3 0.0 0.073 13.4 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease RT_RNaseH_2 PF17919.1 KII71100.1 - 7.5e-22 77.3 0.0 9.6e-22 76.9 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71100.1 - 2.6e-14 53.4 0.0 4.2e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII71101.1 - 1.9e-15 57.1 0.0 6.7e-15 55.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII71101.1 - 0.016 14.9 0.1 0.056 13.2 0.0 2.0 2 0 0 2 2 2 0 Integrase core domain GGA_N-GAT PF18308.1 KII71101.1 - 0.03 13.9 0.7 0.097 12.3 0.4 1.9 2 0 0 2 2 2 0 GGA N-GAT domain DUF5509 PF17625.2 KII71103.1 - 0.2 10.7 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5509) DDE_Tnp_IS1595 PF12762.7 KII71104.1 - 3.6e-10 40.0 0.0 1e-09 38.6 0.0 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII71105.1 - 4.4e-06 26.8 0.0 6e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain P_proprotein PF01483.20 KII71106.1 - 1.1e-15 57.5 0.1 1.7e-15 56.8 0.1 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Sushi PF00084.20 KII71106.1 - 0.12 13.0 0.5 0.3 11.7 0.5 1.6 1 0 0 1 1 1 0 Sushi repeat (SCR repeat) Peptidase_S8 PF00082.22 KII71107.1 - 3e-22 79.3 2.3 4e-22 78.8 2.3 1.2 1 0 0 1 1 1 1 Subtilase family Peptidase_S8 PF00082.22 KII71108.1 - 8.4e-30 104.1 0.2 1.3e-29 103.4 0.2 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KII71108.1 - 7e-16 58.0 0.1 1.5e-15 57.0 0.1 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain SelK_SelG PF10961.8 KII71110.1 - 1.3e-06 28.9 0.1 1.8e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 Selenoprotein SelK_SelG NVEALA PF14055.6 KII71111.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 NVEALA protein UCH PF00443.29 KII71112.1 - 0.069 12.6 0.1 0.069 12.6 0.1 2.0 3 0 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase Sec7 PF01369.20 KII71113.1 - 0.0014 18.4 0.3 0.0015 18.2 0.3 1.1 1 0 0 1 1 1 1 Sec7 domain Gluconate_2-dh3 PF13618.6 KII71113.1 - 0.026 14.8 0.2 0.031 14.5 0.2 1.3 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 SCAPER_N PF16501.5 KII71113.1 - 0.028 14.4 0.4 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 S phase cyclin A-associated protein in the endoplasmic reticulum DUF1548 PF07579.11 KII71113.1 - 0.044 14.1 0.3 0.058 13.7 0.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) ARD PF03079.14 KII71113.1 - 0.14 12.3 0.7 0.2 11.8 0.7 1.2 1 0 0 1 1 1 0 ARD/ARD' family RVT_1 PF00078.27 KII71116.1 - 0.027 14.0 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) PilN PF05137.13 KII71116.1 - 0.048 13.8 0.0 0.073 13.2 0.0 1.3 1 0 0 1 1 1 0 Fimbrial assembly protein (PilN) RVT_1 PF00078.27 KII71118.1 - 1e-07 31.7 0.1 2.4e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII71118.1 - 0.021 15.1 0.0 0.044 14.1 0.0 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase DDE_3 PF13358.6 KII71119.1 - 0.001 18.9 0.0 0.0026 17.5 0.0 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease Transcrip_reg PF01709.20 KII71119.1 - 0.12 11.8 0.0 0.17 11.2 0.0 1.3 1 1 0 1 1 1 0 Transcriptional regulator DUF2341 PF10102.9 KII71121.1 - 0.037 14.6 0.1 0.084 13.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2341) SCAPER_N PF16501.5 KII71121.1 - 0.041 13.9 0.1 0.083 12.9 0.1 1.7 1 0 0 1 1 1 0 S phase cyclin A-associated protein in the endoplasmic reticulum PhoU PF01895.19 KII71121.1 - 0.05 14.1 0.4 4.7 7.8 0.0 2.3 2 1 0 2 2 2 0 PhoU domain ING PF12998.7 KII71121.1 - 1.2 9.8 9.5 0.41 11.3 2.8 2.6 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding SirA PF10747.9 KII71121.1 - 4.2 7.7 11.2 9 6.6 0.9 2.8 2 1 1 3 3 3 0 Sporulation inhibitor of replication protein SirA RVT_1 PF00078.27 KII71122.1 - 3.5e-12 46.3 0.0 5.6e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SeleniumBinding PF11524.8 KII71122.1 - 0.14 12.6 0.0 0.54 10.7 0.0 1.9 2 0 0 2 2 2 0 Selenium binding protein HTH_23 PF13384.6 KII71124.1 - 1.8e-08 33.9 0.1 4.5e-06 26.3 0.0 2.7 2 1 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 KII71124.1 - 3.6e-06 27.5 0.3 6.3e-05 23.5 0.1 2.3 2 1 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII71124.1 - 5e-05 23.5 0.2 0.00013 22.1 0.1 1.8 2 0 0 2 2 1 1 Transposase HTH_33 PF13592.6 KII71124.1 - 6.9e-05 22.4 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_29 PF13551.6 KII71124.1 - 7.2e-05 22.7 0.0 0.00017 21.5 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 KII71124.1 - 0.00013 22.0 0.0 0.001 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII71124.1 - 0.00051 20.0 0.2 0.00073 19.5 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_24 PF13412.6 KII71124.1 - 0.0078 15.7 0.2 3.1 7.4 0.0 2.4 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_3 PF01381.22 KII71124.1 - 0.0081 16.2 0.1 0.084 13.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix Sigma70_r4 PF04545.16 KII71124.1 - 0.0092 15.5 0.2 0.082 12.4 0.0 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 TrmB PF01978.19 KII71124.1 - 0.01 15.7 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_psq PF05225.16 KII71124.1 - 0.014 15.1 0.1 0.86 9.4 0.0 2.3 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_Tnp_ISL3 PF13542.6 KII71124.1 - 0.02 14.3 0.0 6.4 6.3 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_38 PF13936.6 KII71124.1 - 0.037 13.8 0.3 0.16 11.8 0.1 2.1 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_11 PF08279.12 KII71124.1 - 0.038 13.9 0.1 0.083 12.9 0.1 1.5 1 0 0 1 1 1 0 HTH domain Nuc_rec_co-act PF08815.10 KII71124.1 - 0.041 13.7 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 Nuclear receptor coactivator MarR_2 PF12802.7 KII71124.1 - 0.045 13.6 0.0 0.61 10.0 0.0 2.2 2 0 0 2 2 2 0 MarR family HTH_50 PF18024.1 KII71124.1 - 0.047 13.3 0.0 7.7 6.2 0.0 2.8 2 1 0 2 2 2 0 Helix-turn-helix domain RuBisCO_small PF00101.20 KII71124.1 - 0.053 13.5 0.2 0.1 12.6 0.0 1.5 2 0 0 2 2 1 0 Ribulose bisphosphate carboxylase, small chain HTH_17 PF12728.7 KII71124.1 - 0.065 13.4 0.1 19 5.6 0.0 2.6 3 0 0 3 3 2 0 Helix-turn-helix domain HTH_37 PF13744.6 KII71124.1 - 0.092 12.7 0.0 0.51 10.3 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII71124.1 - 0.13 12.0 0.1 5.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 Ank_4 PF13637.6 KII71125.1 - 6.1e-24 84.1 1.0 5.6e-12 45.9 0.2 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KII71125.1 - 5.2e-17 62.2 0.2 2e-16 60.3 0.1 1.8 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KII71125.1 - 4.5e-15 55.5 0.4 2.2e-07 31.0 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII71125.1 - 4.8e-14 51.1 0.0 8.7e-07 28.8 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KII71125.1 - 1.2e-12 47.6 0.1 2.1e-06 27.9 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat DUF3723 PF12520.8 KII71126.1 - 0.052 12.2 0.1 0.064 11.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3723) TilS_C PF11734.8 KII71126.1 - 0.065 12.7 0.0 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 TilS substrate C-terminal domain DDE_3 PF13358.6 KII71129.1 - 6e-05 22.8 0.1 8.8e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease XS PF03468.14 KII71129.1 - 0.083 13.2 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 XS domain Integrase_H2C2 PF17921.1 KII71129.1 - 0.092 12.9 1.5 0.11 12.7 0.1 1.8 2 0 0 2 2 2 0 Integrase zinc binding domain MRAP PF15183.6 KII71132.1 - 0.068 13.1 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family Vps5 PF09325.10 KII71134.1 - 5.4e-17 62.1 8.9 1.8e-14 53.8 8.9 2.0 1 1 0 1 1 1 1 Vps5 C terminal like BAR_3_WASP_bdg PF10456.9 KII71134.1 - 0.0031 17.0 4.6 0.0061 16.1 4.4 1.6 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PfUIS3 PF11567.8 KII71134.1 - 0.043 14.2 0.4 0.043 14.2 0.4 2.5 2 1 2 4 4 4 0 Plasmodium falciparum UIS3 membrane protein PSII_Pbs27 PF13326.6 KII71134.1 - 0.14 12.5 1.8 0.57 10.5 0.1 2.1 2 0 0 2 2 2 0 Photosystem II Pbs27 Mei5_like PF17021.5 KII71134.1 - 0.16 12.0 4.7 0.18 11.8 0.9 2.6 2 1 0 2 2 2 0 Putative double-strand recombination repair-like Plk4_PB2 PF18409.1 KII71134.1 - 0.26 12.0 6.7 0.79 10.4 2.1 2.6 1 1 0 2 2 2 0 Polo-like Kinase 4 Polo Box 2 DUF5344 PF17279.2 KII71134.1 - 1.5 9.5 6.1 2.7 8.6 0.9 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5344) rve PF00665.26 KII71135.1 - 3.4e-24 85.3 0.0 7.7e-24 84.2 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71135.1 - 7.5e-07 29.2 0.3 7.5e-07 29.2 0.3 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain zf-CCHC PF00098.23 KII71135.1 - 6.9e-06 25.9 10.7 2.6e-05 24.1 1.8 2.6 2 0 0 2 2 2 2 Zinc knuckle RVT_1 PF00078.27 KII71135.1 - 8.6e-06 25.4 0.2 1.8e-05 24.4 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 KII71135.1 - 0.01 15.6 0.0 0.032 14.0 0.0 1.9 1 0 0 1 1 1 0 Integrase core domain RVP_2 PF08284.11 KII71135.1 - 0.014 15.1 0.2 0.058 13.2 0.1 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease DDE_Tnp_IS240 PF13610.6 KII71135.1 - 0.016 15.5 0.7 0.034 14.4 0.0 1.8 2 0 0 2 2 2 0 DDE domain gag-asp_proteas PF13975.6 KII71135.1 - 0.031 14.8 0.1 0.079 13.5 0.1 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_4 PF14392.6 KII71135.1 - 0.17 11.6 7.1 3 7.6 0.5 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 KII71135.1 - 2.1 8.3 11.1 5.1 7.0 0.7 2.9 2 0 0 2 2 2 0 Zinc knuckle MutS_V PF00488.21 KII71136.1 - 1.1e-76 257.1 0.1 1.9e-76 256.3 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KII71136.1 - 3e-25 89.6 0.2 8.1e-25 88.2 0.2 1.8 1 1 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 KII71136.1 - 1.1e-11 44.9 1.1 2.5e-11 43.8 1.1 1.7 1 0 0 1 1 1 1 MutS family domain IV CdvA PF18822.1 KII71136.1 - 0.069 13.0 2.2 6.3 6.6 0.2 3.0 3 0 0 3 3 3 0 CdvA-like coiled-coil domain AAA_27 PF13514.6 KII71136.1 - 0.16 11.6 0.0 0.67 9.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain MutS_II PF05188.17 KII71136.1 - 0.34 11.2 2.5 0.5 10.7 0.0 2.6 4 0 0 4 4 4 0 MutS domain II ArfGap PF01412.18 KII71137.1 - 5.4e-31 107.1 0.1 5.4e-31 107.1 0.1 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 KII71137.1 - 1.9e-12 47.6 0.9 6.5e-12 45.9 0.9 2.0 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.7 KII71137.1 - 3e-09 37.4 0.0 6.4e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KII71137.1 - 1.8e-07 31.6 0.0 1.2e-06 29.0 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KII71137.1 - 1.1e-06 28.8 0.0 2.4e-05 24.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat BAR_3 PF16746.5 KII71137.1 - 1.3e-06 28.3 18.1 2.4e-06 27.4 18.1 1.3 1 0 0 1 1 1 1 BAR domain of APPL family Ank_5 PF13857.6 KII71137.1 - 1.6e-06 28.3 0.0 3.6e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KII71137.1 - 0.00015 22.0 0.1 0.00096 19.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ribosomal_L16 PF00252.18 KII71138.1 - 1.2e-40 138.6 0.0 1.4e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Gal-3-0_sulfotr PF06990.11 KII71141.1 - 4.7e-17 62.0 7.0 1.2e-15 57.3 7.0 2.0 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase Kelch_6 PF13964.6 KII71142.1 - 4e-18 65.0 8.9 0.00021 21.5 0.0 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KII71142.1 - 6e-17 61.4 3.0 0.032 14.2 0.0 5.2 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII71142.1 - 8.5e-16 57.3 3.7 0.00011 21.7 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 KII71142.1 - 2.6e-10 40.1 3.9 0.00042 20.2 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 KII71142.1 - 3.6e-10 39.9 3.3 0.00079 19.7 0.0 5.1 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII71142.1 - 2.8e-05 23.9 2.9 0.15 12.1 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 KII71144.1 - 2.9e-19 68.6 2.2 6.8e-07 29.4 0.3 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII71144.1 - 2.2e-11 43.6 0.7 0.0039 17.2 0.1 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII71144.1 - 8.8e-10 38.6 0.4 0.0085 16.4 0.1 3.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII71144.1 - 2.1e-09 36.8 3.1 0.00083 18.9 0.6 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII71144.1 - 4.2e-05 23.4 0.5 0.14 12.2 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII71144.1 - 0.059 13.4 4.8 7.4 6.7 0.5 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 KII71145.1 - 0.00048 20.3 0.2 0.078 13.3 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII71145.1 - 0.0044 17.0 2.2 0.043 13.8 0.3 2.4 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 KII71145.1 - 0.18 12.1 0.2 1.9 8.9 0.0 2.3 2 1 0 2 2 2 0 Galactose oxidase, central domain HTH_23 PF13384.6 KII71146.1 - 0.00014 21.5 0.0 0.00027 20.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 KII71146.1 - 0.0016 19.0 0.0 0.0039 17.8 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.18 KII71146.1 - 0.012 15.6 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 'Paired box' domain HTH_40 PF14493.6 KII71146.1 - 0.036 14.5 0.7 0.056 13.9 0.2 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_Tc5 PF03221.16 KII71149.1 - 6.1e-06 26.2 0.4 1e-05 25.5 0.4 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 KII71149.1 - 0.0023 17.5 0.0 0.005 16.4 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_psq PF05225.16 KII71149.1 - 0.006 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain LEF-9 PF05094.12 KII71149.1 - 0.037 12.6 0.1 0.043 12.3 0.1 1.1 1 0 0 1 1 1 0 Late expression factor 9 (LEF-9) Kelch_6 PF13964.6 KII71150.1 - 5.1e-09 36.1 0.1 4.9e-05 23.5 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII71150.1 - 0.00045 20.4 0.0 0.00096 19.4 0.0 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII71150.1 - 0.0025 17.4 0.5 0.0068 16.0 0.1 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 KII71150.1 - 0.013 15.5 0.1 0.032 14.2 0.0 1.7 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 KII71151.1 - 5.8e-20 70.8 14.9 0.00045 20.4 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 KII71151.1 - 1.5e-15 56.5 24.2 0.00038 20.0 0.1 6.8 7 0 0 7 7 7 6 Kelch motif Kelch_4 PF13418.6 KII71151.1 - 2.6e-14 52.9 12.3 0.021 14.8 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KII71151.1 - 1.9e-09 37.1 15.8 0.1 12.6 0.2 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII71151.1 - 2.9e-08 33.8 12.3 0.014 15.6 0.0 6.6 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII71151.1 - 6e-07 29.3 10.2 0.031 14.3 0.0 5.4 5 0 0 5 5 5 2 Kelch motif RVT_1 PF00078.27 KII71155.1 - 0.0014 18.2 0.0 0.0063 16.0 0.0 2.0 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4044 PF13253.6 KII71162.1 - 0.018 14.5 1.0 0.038 13.5 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) DDE_3 PF13358.6 KII71163.1 - 0.0087 15.8 0.1 0.026 14.3 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease REV PF00424.18 KII71164.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) Kelch_1 PF01344.25 KII71166.1 - 5.5e-19 67.5 19.1 0.00017 21.1 0.4 6.4 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 KII71166.1 - 6.8e-18 64.3 16.6 0.0052 17.0 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII71166.1 - 2.1e-12 47.0 15.5 0.0089 16.3 0.1 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KII71166.1 - 3.3e-11 43.0 15.3 0.058 13.4 0.5 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII71166.1 - 9.5e-11 41.4 14.3 1.6e-05 24.8 0.0 6.3 7 0 0 7 7 7 3 Kelch motif Kelch_2 PF07646.15 KII71166.1 - 1.6e-08 34.2 12.5 0.00095 19.1 0.1 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KII71168.1 - 1e-21 76.2 13.5 4e-06 26.3 0.0 6.8 6 1 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KII71168.1 - 5.2e-19 67.8 16.3 0.00028 21.1 0.5 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII71168.1 - 3.8e-15 55.6 17.1 0.024 14.7 0.2 6.6 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 KII71168.1 - 1.9e-12 47.1 14.9 0.0013 19.0 0.2 6.1 5 1 2 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KII71168.1 - 1.8e-08 34.2 11.7 0.11 12.5 0.0 5.2 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KII71168.1 - 5.8e-08 32.4 12.6 0.87 9.7 0.0 6.3 6 0 0 6 6 6 4 Kelch motif DUF3048_C PF17479.2 KII71168.1 - 0.076 13.4 1.1 0.11 12.9 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3048) C-terminal domain Asp_protease_2 PF13650.6 KII71170.1 - 5.5e-05 23.7 0.0 0.00011 22.7 0.0 1.5 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 KII71170.1 - 0.0081 16.7 0.0 0.019 15.5 0.0 1.6 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease zf-C2H2_10 PF16588.5 KII71170.1 - 0.01 15.5 1.2 0.02 14.6 1.2 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger RVP PF00077.20 KII71170.1 - 0.08 13.3 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Retroviral aspartyl protease JLPA PF16668.5 KII71172.1 - 3.2e-07 29.7 0.3 0.33 10.0 0.0 3.3 1 1 1 3 3 3 3 Adhesin from Campylobacter Pentapeptide_4 PF13599.6 KII71172.1 - 0.00038 20.6 4.1 2.2 8.5 0.1 4.0 2 1 2 4 4 4 3 Pentapeptide repeats (9 copies) Vps36_ESCRT-II PF11605.8 KII71172.1 - 0.0073 16.5 20.6 9.9 6.4 2.0 5.8 1 1 5 6 6 6 6 Vacuolar protein sorting protein 36 Vps36 Spo7_2_N PF15407.6 KII71172.1 - 0.016 14.8 21.8 65 3.3 0.1 8.7 2 1 10 12 12 12 0 Sporulation protein family 7 PLA2_inh PF02988.15 KII71172.1 - 2.1 9.1 9.0 74 4.1 0.8 3.7 1 1 4 5 5 5 0 Phospholipase A2 inhibitor Mur_ligase_M PF08245.12 KII71174.1 - 0.045 13.7 0.0 0.057 13.4 0.0 1.1 1 0 0 1 1 1 0 Mur ligase middle domain RT_RNaseH_2 PF17919.1 KII71175.1 - 1.3e-05 25.2 0.1 6.2e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71175.1 - 0.00035 20.8 0.3 0.0034 17.7 0.0 2.6 2 1 1 3 3 3 1 RNase H-like domain found in reverse transcriptase Kelch_4 PF13418.6 KII71176.1 - 4.3e-24 84.3 16.8 6.2e-05 22.9 0.2 6.2 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 KII71176.1 - 7e-20 70.6 19.1 3.5e-09 36.6 0.2 5.7 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KII71176.1 - 1.3e-19 69.5 18.4 1.1e-07 31.3 0.2 5.9 6 1 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII71176.1 - 5.1e-13 49.0 14.3 0.0011 19.2 0.1 6.3 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII71176.1 - 2.1e-11 43.6 8.3 0.00061 19.7 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 KII71176.1 - 9.3e-10 38.1 11.8 0.049 13.6 0.1 5.5 6 0 0 6 6 6 4 Kelch motif RPT PF13446.6 KII71176.1 - 0.017 15.1 0.1 0.39 10.7 0.0 2.6 3 0 0 3 3 3 0 A repeated domain in UCH-protein DUF5074 PF16819.5 KII71176.1 - 0.94 9.5 5.3 4.5 7.3 2.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5074) Kelch_6 PF13964.6 KII71177.1 - 5.2e-05 23.4 1.3 0.37 11.2 0.0 3.0 2 1 1 3 3 3 2 Kelch motif Kelch_1 PF01344.25 KII71177.1 - 0.0077 15.8 0.6 3.6 7.3 0.4 2.6 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII71177.1 - 0.0082 16.1 0.1 2.2 8.3 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII71177.1 - 0.066 13.2 0.8 0.73 9.9 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 KII71178.1 - 3.8e-28 96.8 13.5 2.9e-06 27.3 0.2 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KII71178.1 - 1.2e-15 57.2 11.7 5.3e-05 23.2 0.1 5.8 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KII71178.1 - 1.3e-14 54.1 6.1 1.1e-05 25.5 0.1 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII71178.1 - 1.8e-14 53.0 17.1 4.6e-06 26.1 0.1 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KII71178.1 - 2.5e-09 36.7 8.1 0.2 11.7 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII71178.1 - 1e-08 35.0 8.5 0.00026 20.9 0.1 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 KII71179.1 - 0.0046 17.2 0.4 1.4 9.3 0.3 2.3 1 1 1 2 2 2 2 Kelch motif Kelch_6 PF13964.6 KII71180.1 - 8.6e-06 25.9 0.6 0.021 15.1 0.1 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII71180.1 - 8.6e-05 22.5 2.2 0.0014 18.6 0.2 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 KII71180.1 - 0.00023 21.4 0.7 0.0021 18.3 0.1 2.3 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII71180.1 - 0.00071 19.1 0.0 0.14 11.8 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII71180.1 - 0.014 15.4 3.0 0.022 14.8 0.4 2.1 1 1 1 2 2 2 0 Kelch motif Kelch_5 PF13854.6 KII71180.1 - 0.15 12.0 1.2 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 Kelch motif FLYWCH PF04500.16 KII71181.1 - 0.0002 21.4 2.5 0.00055 20.0 2.5 1.8 1 1 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII71181.1 - 0.018 15.4 0.2 0.038 14.4 0.2 1.6 1 0 0 1 1 1 0 MULE transposase domain DUF5470 PF17564.2 KII71181.1 - 0.029 14.6 3.0 0.15 12.2 0.1 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5470) I-set PF07679.16 KII71181.1 - 0.15 12.1 0.1 0.29 11.2 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Kelch_3 PF13415.6 KII71182.1 - 0.012 15.9 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain CENP-B_dimeris PF09026.10 KII71184.1 - 0.00017 21.9 2.7 0.0002 21.7 2.7 1.2 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Voldacs PF03517.13 KII71184.1 - 0.08 13.1 3.5 0.11 12.6 3.5 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling PBP1_TM PF14812.6 KII71184.1 - 0.54 10.7 4.8 0.77 10.2 4.8 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mso1_Sec1_bdg PF14475.6 KII71184.1 - 2.7 7.7 5.1 23 4.7 4.7 2.1 2 0 0 2 2 2 0 Sec1-binding region of Mso1 Frag1 PF10277.9 KII71187.1 - 0.098 12.2 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family MLVIN_C PF18697.1 KII71190.1 - 3.4e-05 23.8 0.0 4.7e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve PF00665.26 KII71191.1 - 3.1e-16 59.6 0.1 1e-15 58.0 0.0 1.6 1 1 1 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII71191.1 - 0.012 15.4 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Kelch_3 PF13415.6 KII71194.1 - 8.5e-08 32.3 0.2 6.8e-05 23.0 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KII71194.1 - 1.3e-07 31.6 4.3 0.029 14.7 0.1 4.4 4 1 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 KII71194.1 - 1.6e-07 31.2 7.3 0.024 14.6 0.1 4.5 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII71194.1 - 0.0012 18.7 3.2 1.6 8.8 0.0 3.7 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 KII71194.1 - 0.0062 16.1 5.7 2.8 7.6 0.1 4.3 5 0 0 5 5 5 2 Kelch motif BTB_2 PF02214.22 KII71194.1 - 0.045 14.1 0.1 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 BTB/POZ domain Kelch_5 PF13854.6 KII71194.1 - 0.098 12.7 1.3 3.8 7.6 0.0 2.9 3 0 0 3 3 3 0 Kelch motif Ribosomal_L37e PF01907.19 KII71195.1 - 0.0036 17.4 0.8 0.008 16.3 0.8 1.6 1 0 0 1 1 1 1 Ribosomal protein L37e Rhabdo_M1 PF03342.13 KII71195.1 - 0.12 11.8 0.2 0.32 10.3 0.2 1.8 1 1 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) rve PF00665.26 KII71196.1 - 7.1e-17 61.7 0.0 1.4e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71196.1 - 6.9e-15 54.9 0.7 1.7e-14 53.6 0.3 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII71196.1 - 0.0075 16.5 0.0 0.018 15.3 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger TSNAXIP1_N PF15739.5 KII71196.1 - 0.038 14.4 0.2 0.074 13.4 0.2 1.5 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus MLVIN_C PF18697.1 KII71197.1 - 0.0019 18.3 0.1 0.0042 17.2 0.1 1.5 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain C4 PF01413.19 KII71202.1 - 0.016 15.5 0.2 0.037 14.4 0.2 1.6 1 0 0 1 1 1 0 C-terminal tandem repeated domain in type 4 procollagen DUF3623 PF12291.8 KII71203.1 - 0.076 12.2 0.0 0.094 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3623) DDE_Tnp_IS1595 PF12762.7 KII71204.1 - 0.0046 17.0 0.0 0.0097 15.9 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain DUF4974 PF16344.5 KII71205.1 - 0.0038 17.2 0.6 0.017 15.1 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4974) FERM_N_2 PF18038.1 KII71207.1 - 0.026 15.4 0.9 0.073 13.9 0.3 2.0 2 0 0 2 2 2 0 FERM N-terminal domain ADH_N PF08240.12 KII71207.1 - 0.079 12.9 0.5 0.15 11.9 0.5 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain gag-asp_proteas PF13975.6 KII71207.1 - 0.088 13.4 0.0 0.21 12.2 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease P_C10 PF14974.6 KII71207.1 - 0.14 12.3 0.1 0.83 9.8 0.0 2.1 1 1 1 2 2 2 0 Protein C10 RVT_1 PF00078.27 KII71209.1 - 4.5e-09 36.1 0.0 6.6e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SPAM PF02090.15 KII71209.1 - 0.068 13.0 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein rve PF00665.26 KII71210.1 - 1.5e-06 28.3 0.0 2.7e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain CbiG_mid PF11761.8 KII71211.1 - 0.025 14.7 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Cobalamin biosynthesis central region Sortilin-Vps10 PF15902.5 KII71212.1 - 8.5e-08 31.4 0.4 2.2e-06 26.7 0.0 2.8 2 1 1 3 3 3 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII71212.1 - 1.3e-07 32.1 7.1 2.4e-07 31.3 7.1 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Suppressor_APC PF11414.8 KII71212.1 - 0.0019 18.2 0.0 0.092 12.8 0.0 2.4 2 0 0 2 2 2 1 Adenomatous polyposis coli tumour suppressor protein BNR PF02012.20 KII71212.1 - 0.025 14.5 3.6 4.3 7.7 0.2 3.4 3 0 0 3 3 3 0 BNR/Asp-box repeat Phospholamban PF04272.14 KII71213.1 - 0.059 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Phospholamban Ldl_recept_a PF00057.18 KII71213.1 - 4.1 7.7 16.5 0.74 10.1 4.3 3.3 2 1 0 2 2 2 0 Low-density lipoprotein receptor domain class A Herpes_IE1 PF07340.11 KII71214.1 - 0.058 12.3 0.1 0.074 12.0 0.1 1.1 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein DDE_3 PF13358.6 KII71215.1 - 1.4e-22 80.0 0.1 1e-20 74.0 0.1 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF2024 PF09630.10 KII71215.1 - 0.0053 16.6 0.1 0.01 15.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) Colicin_Pyocin PF01320.18 KII71215.1 - 0.0069 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein rve PF00665.26 KII71217.1 - 1.7e-11 44.4 0.0 2.3e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII71217.1 - 0.00022 20.9 0.0 0.00046 19.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Reg_prop PF07494.11 KII71218.1 - 0.022 14.9 0.2 4.5 7.8 0.0 3.8 3 0 0 3 3 3 0 Two component regulator propeller YcgR_2 PF12945.7 KII71218.1 - 0.063 13.4 0.1 1.1 9.4 0.0 3.0 3 2 0 3 3 3 0 Flagellar protein YcgR UPF0122 PF04297.14 KII71222.1 - 0.14 12.4 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like RVT_3 PF13456.6 KII71225.1 - 0.1 12.4 0.2 0.53 10.1 0.1 1.8 1 1 1 2 2 2 0 Reverse transcriptase-like DDE_1 PF03184.19 KII71226.1 - 3.9e-27 95.0 0.1 4.8e-27 94.7 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease CBP_GIL PF10995.8 KII71226.1 - 0.12 11.0 0.1 0.14 10.8 0.1 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis GIL Serpin PF00079.20 KII71229.1 - 2.7e-15 56.5 0.1 3.3e-15 56.3 0.1 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) rve PF00665.26 KII71231.1 - 1.1e-10 41.8 0.1 1.5e-10 41.3 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71231.1 - 1.6e-09 37.7 1.5 4.4e-09 36.3 0.2 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain PocR PF10114.9 KII71231.1 - 0.01 15.6 0.1 0.11 12.2 0.2 2.0 2 0 0 2 2 2 0 Sensory domain found in PocR CLTH PF10607.9 KII71232.1 - 0.026 14.4 0.0 0.11 12.4 0.0 2.0 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DDE_3 PF13358.6 KII71233.1 - 1.8e-14 53.7 0.2 2.1e-14 53.5 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Serpin PF00079.20 KII71234.1 - 0.00021 20.7 0.0 0.00026 20.4 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) UCH PF00443.29 KII71235.1 - 0.069 12.6 0.1 0.069 12.6 0.1 2.0 3 0 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase HTH_32 PF13565.6 KII71237.1 - 0.17 12.5 0.8 0.36 11.5 0.1 1.8 2 1 0 2 2 2 0 Homeodomain-like domain HTH_23 PF13384.6 KII71237.1 - 0.21 11.4 0.6 2.4 8.1 0.1 2.3 2 0 0 2 2 2 0 Homeodomain-like domain PLC-beta_C PF08703.10 KII71238.1 - 0.075 13.0 0.0 0.079 12.9 0.0 1.2 1 0 0 1 1 1 0 PLC-beta C terminal Serpin PF00079.20 KII71239.1 - 1.6e-29 103.4 0.4 1.8e-29 103.2 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Glyco_hydro_38 PF18438.1 KII71239.1 - 0.11 12.6 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal domain 1 HTH_Tnp_IS630 PF01710.16 KII71242.1 - 0.048 13.7 0.0 0.096 12.7 0.0 1.4 1 0 0 1 1 1 0 Transposase DUF2209 PF09974.9 KII71242.1 - 0.067 13.5 0.2 0.094 13.1 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) PSRT PF07636.11 KII71243.1 - 0.15 11.8 1.2 0.25 11.1 1.2 1.3 1 0 0 1 1 1 0 PSRT Kelch_6 PF13964.6 KII71245.1 - 4.5e-15 55.3 15.7 0.0049 17.1 0.1 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII71245.1 - 2.9e-12 46.4 9.8 0.0018 18.2 0.1 5.9 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII71245.1 - 2.3e-08 33.5 12.7 0.012 15.2 0.1 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII71245.1 - 7.6e-08 32.5 7.8 0.0092 16.3 0.2 5.2 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII71245.1 - 0.00014 21.7 9.6 21 5.3 0.0 6.3 6 0 0 6 6 6 1 Kelch motif Kelch_5 PF13854.6 KII71245.1 - 0.00069 19.5 16.1 0.16 12.0 0.0 5.0 5 1 0 5 5 5 2 Kelch motif RVT_1 PF00078.27 KII71246.1 - 1.2e-08 34.8 0.0 1.7e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII71249.1 - 3.7e-10 39.8 0.0 9.4e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII71249.1 - 2.8e-07 30.7 0.0 6.6e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 KII71249.1 - 0.0067 16.7 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase SSV1_ORF_D-335 PF07935.11 KII71250.1 - 0.12 12.7 29.1 62 4.0 0.4 8.7 1 1 6 7 7 7 0 ORF D-335-like protein rve PF00665.26 KII71252.1 - 9.9e-20 70.9 0.2 2.7e-19 69.5 0.1 1.8 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71252.1 - 1.4e-16 60.3 0.3 3.5e-16 59.0 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII71252.1 - 0.00013 22.1 0.6 0.00029 21.0 0.1 1.9 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII71252.1 - 0.00065 19.4 0.0 0.0018 18.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII71252.1 - 0.073 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Nepo_coat_N PF03689.15 KII71252.1 - 0.094 12.7 0.1 0.43 10.5 0.0 2.0 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain PBP PF01161.20 KII71254.1 - 6.3e-12 46.0 0.0 7.4e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein RsgI_N PF12791.7 KII71256.1 - 0.09 12.7 0.3 0.25 11.3 0.1 1.8 2 0 0 2 2 2 0 Anti-sigma factor N-terminus RVT_1 PF00078.27 KII71261.1 - 6.3e-19 68.4 0.1 1e-18 67.7 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L2_C PF03947.18 KII71264.1 - 2.1e-45 154.0 1.9 3.1e-45 153.4 1.9 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KII71264.1 - 7.9e-15 54.6 0.2 2.9e-14 52.8 0.2 2.0 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain CSTF1_dimer PF16699.5 KII71265.1 - 2.8e-12 46.2 0.0 5.1e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain WD40 PF00400.32 KII71265.1 - 1.5e-11 44.7 1.3 0.0038 18.0 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII71265.1 - 7.7e-06 26.1 0.0 0.17 12.2 0.0 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KII71265.1 - 0.0037 15.6 0.1 0.0048 15.3 0.1 1.1 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KII71265.1 - 0.029 14.2 0.1 0.082 12.8 0.1 1.7 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A ARID PF01388.21 KII71266.1 - 1.3e-14 54.7 0.2 2.1e-14 53.9 0.2 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Met_asp_mut_E PF06368.11 KII71266.1 - 0.24 9.9 0.0 0.35 9.3 0.0 1.1 1 0 0 1 1 1 0 Methylaspartate mutase E chain (MutE) FerI PF08151.12 KII71267.1 - 0.058 13.5 0.0 0.09 12.9 0.0 1.3 1 0 0 1 1 1 0 FerI (NUC094) domain EF1G PF00647.19 KII71269.1 - 9.7e-30 102.8 0.2 1.6e-29 102.1 0.2 1.3 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain Med6 PF04934.14 KII71269.1 - 0.011 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 MED6 mediator sub complex component DUF4770 PF15994.5 KII71269.1 - 0.012 15.9 9.2 0.021 15.0 9.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) PRTP PF01366.18 KII71269.1 - 0.17 9.9 0.9 0.19 9.8 0.9 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Sporozoite_P67 PF05642.11 KII71269.1 - 1.3 7.0 5.8 1.5 6.8 5.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CPSF100_C PF13299.6 KII71269.1 - 3.4 7.8 6.9 4.8 7.3 6.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PMC2NT PF08066.12 KII71270.1 - 0.12 13.1 0.1 0.16 12.7 0.1 1.2 1 0 0 1 1 1 0 PMC2NT (NUC016) domain Rio2_N PF09202.11 KII71270.1 - 0.15 12.3 0.0 0.31 11.3 0.0 1.6 2 0 0 2 2 2 0 Rio2, N-terminal ABC_tran_Xtn PF12848.7 KII71270.1 - 0.36 10.9 2.3 1.6 8.8 0.1 2.5 2 1 0 2 2 2 0 ABC transporter Baculo_RING PF05883.11 KII71271.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain Metallophos PF00149.28 KII71273.1 - 4.3e-08 33.9 4.9 5.6e-08 33.5 4.9 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Proteasome PF00227.26 KII71274.1 - 5.8e-38 130.3 0.5 6.9e-38 130.0 0.5 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 KII71274.1 - 0.023 14.1 1.3 0.023 14.1 1.3 2.4 3 0 0 3 3 3 0 Proteasome beta subunits C terminal HAP2-GCS1 PF10699.9 KII71275.1 - 4.3e-13 49.0 2.2 6.1e-13 48.5 0.1 2.1 1 1 1 2 2 2 1 Male gamete fusion factor DDE_3 PF13358.6 KII71278.1 - 0.062 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_3 PF13358.6 KII71279.1 - 1.8e-19 69.9 0.0 2.1e-19 69.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Ldl_recept_a PF00057.18 KII71282.1 - 2.8e-06 27.4 8.8 2.8e-06 27.4 8.8 3.6 4 0 0 4 4 4 2 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII71282.1 - 0.0034 16.2 0.0 0.0061 15.4 0.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, KH_dom-like PF14714.6 KII71282.1 - 0.053 13.8 0.2 0.92 9.9 0.0 2.8 2 0 0 2 2 2 0 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal Ldl_recept_a PF00057.18 KII71283.1 - 8.9e-07 29.0 8.2 8.9e-07 29.0 8.2 3.3 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII71284.1 - 3.6e-08 33.9 0.3 6.1e-08 33.2 0.3 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII71284.1 - 2.3e-06 26.7 0.1 1.6e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, CHB_HEX_C PF03174.13 KII71284.1 - 0.018 15.0 0.1 0.42 10.6 0.0 2.5 1 1 1 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain BNR PF02012.20 KII71284.1 - 0.071 13.1 3.2 2.3 8.6 0.1 3.0 3 0 0 3 3 3 0 BNR/Asp-box repeat SKI PF01202.22 KII71285.1 - 0.074 13.2 0.2 0.091 12.9 0.2 1.1 1 0 0 1 1 1 0 Shikimate kinase MULE PF10551.9 KII71289.1 - 0.00038 20.8 0.1 0.00071 19.9 0.1 1.4 1 0 0 1 1 1 1 MULE transposase domain Sulfate_transp PF00916.20 KII71290.1 - 1.7e-84 283.8 23.2 2.2e-84 283.4 23.2 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KII71290.1 - 5.1e-05 22.9 0.2 9.9e-05 22.0 0.2 1.5 1 0 0 1 1 1 1 STAS domain SUKH_5 PF14567.6 KII71290.1 - 0.092 12.5 0.2 0.33 10.7 0.1 1.9 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall DUF3937 PF13073.6 KII71290.1 - 0.94 9.6 10.6 3.2 8.0 0.4 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3937) Acetyltransf_19 PF18015.1 KII71292.1 - 0.048 13.9 0.1 0.098 12.9 0.1 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Sulfate_transp PF00916.20 KII71293.1 - 4e-57 193.7 9.7 4.8e-57 193.4 9.7 1.0 1 0 0 1 1 1 1 Sulfate permease family 7tm_1 PF00001.21 KII71295.1 - 3.4e-18 65.9 21.1 5e-18 65.4 21.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2530 PF10745.9 KII71295.1 - 0.059 13.6 0.4 0.22 11.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) RE_Eco29kI PF09517.10 KII71298.1 - 0.18 11.4 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Eco29kI restriction endonuclease RT_RNaseH_2 PF17919.1 KII71300.1 - 2.1e-10 40.5 0.0 3.2e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71300.1 - 0.058 13.7 0.0 0.091 13.1 0.0 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71303.1 - 1.5e-10 41.3 0.0 2.5e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71303.1 - 3e-06 27.2 0.0 5.3e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Vanabin-2 PF11437.8 KII71306.1 - 0.041 14.0 4.7 0.065 13.4 4.7 1.2 1 0 0 1 1 1 0 Vanadium-binding protein 2 RT_RNaseH PF17917.1 KII71307.1 - 1e-10 41.8 0.0 1.6e-07 31.5 0.0 2.1 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71307.1 - 1.9e-09 37.5 0.0 2.6e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Gelsolin PF00626.22 KII71310.1 - 0.056 13.4 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 Gelsolin repeat UPF0180 PF03698.13 KII71312.1 - 8.6 6.6 8.1 30 4.9 1.3 4.0 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0180) DUF5311 PF17238.2 KII71313.1 - 0.018 14.9 0.3 0.062 13.2 0.1 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5311) RVT_1 PF00078.27 KII71321.1 - 0.0027 17.3 0.1 0.0043 16.6 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) XFP_C PF09363.10 KII71321.1 - 0.11 12.0 0.5 0.18 11.2 0.1 1.4 2 0 0 2 2 2 0 XFP C-terminal domain rve PF00665.26 KII71322.1 - 1.1e-22 80.4 0.0 2.8e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71322.1 - 9.2e-13 48.1 0.8 2.1e-12 47.0 0.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII71322.1 - 0.012 15.3 1.6 0.013 15.2 0.0 2.0 2 0 0 2 2 2 0 Integrase core domain DUF1231 PF06802.11 KII71323.1 - 0.0099 15.0 0.2 0.016 14.4 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1231) Tropomyosin_1 PF12718.7 KII71324.1 - 0.0048 17.1 21.0 0.0048 17.1 21.0 2.5 2 1 0 2 2 2 1 Tropomyosin like Spc7 PF08317.11 KII71324.1 - 0.18 10.6 30.8 0.14 11.0 6.7 3.4 1 1 2 3 3 3 0 Spc7 kinetochore protein FlaC_arch PF05377.11 KII71324.1 - 1.3 9.5 21.1 0.78 10.2 4.6 4.0 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 KII71324.1 - 1.5 8.0 17.8 2.5 7.3 10.2 2.2 2 0 0 2 2 2 0 TMPIT-like protein 5_nucleotid PF05761.14 KII71324.1 - 2.9 6.7 13.9 1 8.2 1.1 2.2 2 0 0 2 2 2 0 5' nucleotidase family CtIP_N PF10482.9 KII71324.1 - 3.7 7.6 24.8 21 5.2 3.4 3.3 2 2 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain MtrG PF04210.13 KII71324.1 - 5.6 6.9 5.5 25 4.8 0.1 3.1 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G FUSC PF04632.12 KII71324.1 - 9 4.7 4.8 9.1 4.7 4.1 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family Folliculin_C PF16692.5 KII71326.1 - 0.0098 15.6 0.7 0.018 14.8 0.7 1.4 1 0 0 1 1 1 1 Folliculin C-terminal domain zf-UBR PF02207.20 KII71328.1 - 2.7e-11 43.5 12.9 6e-11 42.3 12.9 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Serpin PF00079.20 KII71330.1 - 5.6e-14 52.2 2.8 6.8e-14 52.0 2.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Pathogen_betaC1 PF09593.10 KII71334.1 - 0.0021 18.0 0.9 0.63 10.0 0.1 2.7 2 0 0 2 2 2 2 Beta-satellite pathogenicity beta C1 protein RRM_1 PF00076.22 KII71336.1 - 1e-34 118.2 0.9 5.8e-17 61.3 0.1 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII71336.1 - 0.045 13.9 0.1 35 4.6 0.0 3.3 3 2 0 3 3 3 0 RNA recognition motif DYW_deaminase PF14432.6 KII71337.1 - 0.072 13.0 0.0 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 DYW family of nucleic acid deaminases DDE_Tnp_IS1595 PF12762.7 KII71338.1 - 2.4e-15 56.9 0.0 2.7e-15 56.7 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII71338.1 - 0.03 14.1 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease zf_ZIC PF18366.1 KII71338.1 - 0.15 12.2 0.6 0.29 11.3 0.6 1.4 1 0 0 1 1 1 0 Zic proteins zinc finger domain RRM_1 PF00076.22 KII71340.1 - 3.5e-33 113.2 0.8 3.5e-17 62.0 0.1 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MMS19_C PF12460.8 KII71341.1 - 0.00031 20.0 5.0 0.00043 19.5 1.3 2.5 1 1 0 2 2 2 1 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 KII71341.1 - 0.016 15.7 0.1 0.043 14.3 0.1 1.7 1 0 0 1 1 1 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 KII71341.1 - 0.18 12.4 0.9 0.52 10.9 0.2 2.2 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region RVT_1 PF00078.27 KII71342.1 - 1.4e-05 24.7 0.0 2.5e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.16 KII71343.1 - 5.2e-33 114.4 20.6 5.6e-30 104.5 18.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KII71343.1 - 0.0022 17.4 0.1 0.0038 16.6 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB UBA PF00627.31 KII71346.1 - 2.8e-07 30.3 0.3 8.2e-07 28.8 0.1 2.0 2 0 0 2 2 2 1 UBA/TS-N domain HOIP-UBA PF16678.5 KII71346.1 - 0.0087 16.1 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 1 HOIP UBA domain pair Pkinase_Tyr PF07714.17 KII71348.1 - 3.4e-31 108.5 0.0 3.9e-31 108.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KII71348.1 - 2e-09 37.2 0.0 2.5e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH3_1 PF00018.28 KII71349.1 - 7e-10 38.4 0.1 1e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KII71349.1 - 4.1e-08 33.0 0.0 5.8e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KII71349.1 - 3.7e-07 29.7 0.0 5e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain Kri1_C PF12936.7 KII71349.1 - 0.086 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 KRI1-like family C-terminal zf-RING_2 PF13639.6 KII71350.1 - 8.5e-07 29.2 2.7 2e-06 28.0 2.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KII71350.1 - 0.00034 20.4 0.7 0.0012 18.6 0.7 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KII71350.1 - 0.0073 16.0 0.2 0.0073 16.0 0.2 2.2 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 KII71350.1 - 0.04 13.8 2.2 0.93 9.4 2.2 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KII71350.1 - 0.053 13.6 0.6 0.053 13.6 0.6 2.3 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 KII71350.1 - 0.098 12.5 2.8 0.17 11.8 1.0 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Auto_anti-p27 PF06677.12 KII71350.1 - 0.099 12.8 0.6 4.4 7.6 0.1 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-RING_5 PF14634.6 KII71350.1 - 0.19 11.7 3.4 1.6 8.7 3.4 2.3 1 1 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 KII71350.1 - 0.38 11.1 3.6 1.4 9.3 3.6 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain FANCL_C PF11793.8 KII71350.1 - 0.38 11.0 4.4 0.69 10.1 2.7 2.4 2 1 0 2 2 2 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 KII71350.1 - 7.5 6.5 8.6 4.3 7.3 1.6 2.6 1 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KII71352.1 - 2.1e-13 50.3 7.0 2.1e-13 50.3 7.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 KII71352.1 - 7.6e-09 35.2 5.7 1.8e-08 34.0 5.7 1.7 1 0 0 1 1 1 1 RING-like zinc finger zinc_ribbon_9 PF14369.6 KII71352.1 - 2.5e-08 34.0 9.5 8.8e-08 32.3 3.3 3.3 3 0 0 3 3 3 1 zinc-ribbon zf-C3HC4_2 PF13923.6 KII71352.1 - 2.8e-08 33.5 6.7 2.8e-08 33.5 6.7 1.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KII71352.1 - 8.9e-07 28.7 10.6 1.5e-06 27.9 3.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KII71352.1 - 4.5e-06 26.4 6.2 4.5e-06 26.4 6.2 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KII71352.1 - 5.1e-06 26.4 3.7 5.1e-06 26.4 3.7 2.4 2 1 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 KII71352.1 - 7e-06 26.2 13.4 1.3e-05 25.4 11.0 2.4 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KII71352.1 - 1.3e-05 25.1 2.7 1.3e-05 25.1 2.7 2.4 3 1 1 4 4 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 KII71352.1 - 0.0021 18.0 5.0 0.0021 18.0 5.0 1.9 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 KII71352.1 - 0.015 15.2 2.6 0.015 15.2 2.6 2.4 2 1 0 2 2 2 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 KII71352.1 - 0.018 14.6 4.4 0.018 14.6 4.4 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Cnd1 PF12717.7 KII71352.1 - 0.062 13.3 0.0 8.3 6.4 0.0 2.1 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Pep1_7 PF17232.2 KII71352.1 - 0.071 13.6 0.4 0.2 12.1 0.2 1.9 2 0 0 2 2 1 0 Elicitor peptide 1-7 DZR PF12773.7 KII71352.1 - 0.072 13.1 3.5 3.3 7.8 0.4 2.6 2 1 0 2 2 2 0 Double zinc ribbon Prok-RING_4 PF14447.6 KII71352.1 - 0.18 11.7 16.2 0.044 13.7 8.6 2.8 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 KII71352.1 - 0.19 11.9 4.1 0.66 10.2 4.1 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.8 KII71352.1 - 1.3 8.9 6.6 3.4 7.5 6.1 1.9 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zinc-ribbons_6 PF07191.12 KII71352.1 - 2.6 8.1 7.7 14 5.8 0.3 2.8 2 1 1 3 3 3 0 zinc-ribbons RINGv PF12906.7 KII71352.1 - 3.5 7.8 7.1 21 5.3 6.8 2.3 1 1 1 2 2 2 0 RING-variant domain KMP11 PF03037.16 KII71354.1 - 0.035 14.9 0.4 0.09 13.6 0.2 1.8 1 1 0 1 1 1 0 Kinetoplastid membrane protein 11 Homeodomain PF00046.29 KII71355.1 - 1.3e-11 44.2 1.4 2.1e-11 43.5 1.4 1.3 1 0 0 1 1 1 1 Homeodomain Vps53_N PF04100.12 KII71356.1 - 7.8e-64 216.0 13.7 7.8e-64 216.0 13.7 2.1 2 0 0 2 2 2 1 Vps53-like, N-terminal PAZ_siRNAbind PF12212.8 KII71356.1 - 0.031 14.1 1.0 0.12 12.3 0.1 2.4 2 0 0 2 2 2 0 PAZ domain Mlf1IP PF10248.9 KII71356.1 - 0.064 13.2 0.1 1.3 9.0 0.0 2.6 2 0 0 2 2 2 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein RPW8 PF05659.11 KII71356.1 - 0.069 12.8 2.2 0.46 10.2 1.7 2.8 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 MKT1_N PF12247.8 KII71356.1 - 0.078 13.3 0.8 2.5 8.5 0.0 3.4 2 1 0 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication Baculo_PEP_C PF04513.12 KII71356.1 - 1.5 8.8 7.1 5.8 6.9 2.7 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5082 PF16888.5 KII71356.1 - 3.5 7.9 7.5 1 9.6 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) Peptidase_C1 PF00112.23 KII71357.1 - 9.8e-70 235.0 0.0 1.5e-69 234.4 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII71357.1 - 4.7e-09 36.6 4.5 1e-08 35.5 4.5 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KII71357.1 - 0.00025 20.0 0.5 0.0042 15.9 0.0 2.3 2 1 0 2 2 2 1 Peptidase C1-like family Enolase_C PF00113.22 KII71357.1 - 0.027 13.7 0.1 0.076 12.3 0.1 1.6 2 0 0 2 2 2 0 Enolase, C-terminal TIM barrel domain Peptidase_C39_2 PF13529.6 KII71357.1 - 0.15 12.6 0.5 0.28 11.7 0.1 1.7 2 0 0 2 2 2 0 Peptidase_C39 like family Peptidase_C1 PF00112.23 KII71358.1 - 1.2e-57 195.5 0.0 2e-57 194.8 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII71358.1 - 2.6e-10 40.6 2.3 4.5e-10 39.8 2.3 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Cas_Cas7 PF05107.12 KII71358.1 - 0.015 14.8 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Cas7 Peptidase_C1_2 PF03051.15 KII71358.1 - 0.071 11.9 0.1 0.13 11.0 0.1 1.4 1 0 0 1 1 1 0 Peptidase C1-like family rve PF00665.26 KII71359.1 - 1.8e-06 28.1 0.0 3.4e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain NS3_envE PF02723.14 KII71360.1 - 0.052 13.6 2.1 0.13 12.4 2.1 1.6 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E Mac-1 PF09028.10 KII71362.1 - 0.0041 16.3 0.2 0.0049 16.0 0.2 1.0 1 0 0 1 1 1 1 Mac 1 Piwi PF02171.17 KII71362.1 - 0.0051 16.1 2.5 0.0054 16.0 2.0 1.3 1 1 0 1 1 1 1 Piwi domain LytR_cpsA_psr PF03816.14 KII71362.1 - 0.047 13.9 0.4 0.049 13.8 0.4 1.2 1 0 0 1 1 1 0 Cell envelope-related transcriptional attenuator domain HU-CCDC81_euk_1 PF14908.6 KII71362.1 - 0.05 13.8 0.0 0.055 13.6 0.0 1.2 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 DUF5312 PF17239.2 KII71362.1 - 0.11 10.8 0.4 0.12 10.7 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5312) PIF1 PF05970.14 KII71364.1 - 5.9e-05 22.4 0.0 6.6e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase DUF3796 PF12676.7 KII71364.1 - 0.029 14.8 0.1 0.035 14.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3796) HU-CCDC81_bac_2 PF18175.1 KII71364.1 - 0.083 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 Vac14_Fab1_bd PF12755.7 KII71365.1 - 0.0078 16.8 4.2 0.26 11.9 0.1 4.3 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region zf-C3HC4_3 PF13920.6 KII71367.1 - 4.4e-06 26.5 12.7 4.4e-06 26.5 12.7 4.2 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C2H2 PF00096.26 KII71367.1 - 0.0004 20.7 1.0 0.0004 20.7 1.0 5.4 6 0 0 6 6 6 1 Zinc finger, C2H2 type zf-RING_2 PF13639.6 KII71367.1 - 0.0012 19.2 13.8 0.0012 19.2 13.8 4.1 4 1 0 4 4 4 1 Ring finger domain zf-C2H2_4 PF13894.6 KII71367.1 - 0.0015 19.2 0.5 0.0015 19.2 0.5 7.3 8 0 0 8 8 8 1 C2H2-type zinc finger zf-C3HC4 PF00097.25 KII71367.1 - 0.0023 17.8 17.2 0.0023 17.8 17.2 4.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII71367.1 - 0.011 15.5 13.8 0.011 15.5 13.8 3.9 4 1 0 4 4 4 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KII71367.1 - 0.012 15.4 14.3 0.012 15.4 14.3 4.2 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) DUF5318 PF17249.2 KII71367.1 - 1 9.1 4.1 0.66 9.7 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5318) zf-RING_4 PF14570.6 KII71367.1 - 5.2 6.9 20.2 4.3 7.2 11.8 3.5 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Serpin PF00079.20 KII71368.1 - 1.5e-36 126.5 5.0 1.6e-36 126.4 5.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII71369.1 - 1.3e-45 156.3 4.3 1.6e-45 156.0 4.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Thoc2 PF11732.8 KII71369.1 - 0.54 10.3 2.9 4.2 7.5 0.0 3.0 3 1 0 3 3 3 0 Transcription- and export-related complex subunit Serpin PF00079.20 KII71371.1 - 4.3e-21 75.6 0.4 5.6e-21 75.3 0.4 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) IL6Ra-bind PF09240.10 KII71371.1 - 0.16 12.4 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding Integrase_H2C2 PF17921.1 KII71373.1 - 4e-05 23.6 0.0 7.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RNA_replicase_B PF03431.13 KII71373.1 - 0.046 12.2 0.0 0.064 11.7 0.0 1.2 1 0 0 1 1 1 0 RNA replicase, beta-chain Ldl_recept_a PF00057.18 KII71375.1 - 1.1e-10 41.5 32.7 6.8e-06 26.2 12.0 2.3 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII71376.1 - 7.2e-19 67.7 34.8 5.1e-12 45.8 12.1 2.8 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII71377.1 - 1.3e-05 25.6 0.0 2.5e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII71377.1 - 0.85 9.9 0.1 0.85 9.9 0.1 3.1 3 0 0 3 3 3 0 BNR/Asp-box repeat FucT_N PF18025.1 KII71379.1 - 0.084 13.3 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Alpha-(1,3)-fucosyltransferase FucT N-terminal domain Kelch_4 PF13418.6 KII71380.1 - 5.6e-05 23.1 2.6 0.0022 17.9 0.5 2.9 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII71380.1 - 0.012 15.2 0.9 0.66 9.6 0.1 2.5 2 0 0 2 2 2 0 Kelch motif RT_RNaseH_2 PF17919.1 KII71382.1 - 2.7e-31 107.5 0.0 6.2e-31 106.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71382.1 - 1.6e-28 99.0 0.0 3.6e-28 97.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71382.1 - 4.2e-28 98.4 0.0 7.1e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII71382.1 - 1.7e-22 79.8 0.1 7.5e-22 77.8 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71382.1 - 4.2e-15 55.6 0.9 1.6e-14 53.7 0.9 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII71382.1 - 0.00016 22.1 0.0 0.00038 21.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 KII71382.1 - 0.00048 19.9 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII71382.1 - 0.0082 16.4 0.0 0.026 14.9 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-H2C2 PF09337.10 KII71382.1 - 0.021 15.0 0.1 0.079 13.2 0.1 2.1 1 0 0 1 1 1 0 H2C2 zinc finger Asp_protease_2 PF13650.6 KII71382.1 - 0.032 14.9 0.0 0.079 13.6 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease RVT_1 PF00078.27 KII71383.1 - 1.6e-08 34.4 0.0 2.4e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ChitinaseA_N PF08329.10 KII71384.1 - 0.059 13.0 0.7 2.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Chitinase A, N-terminal domain DUF3307 PF11750.8 KII71384.1 - 0.086 12.9 0.4 0.18 11.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3307) RVT_1 PF00078.27 KII71386.1 - 1.1e-08 34.9 0.1 3.1e-08 33.4 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TLP-20 PF06088.11 KII71389.1 - 0.19 11.6 1.7 0.29 11.0 1.7 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Presenilin PF01080.17 KII71389.1 - 0.64 8.7 2.3 0.85 8.3 2.3 1.1 1 0 0 1 1 1 0 Presenilin CAP PF00188.26 KII71398.1 - 0.1 13.4 0.0 6.8 7.5 0.0 2.1 1 1 1 2 2 2 0 Cysteine-rich secretory protein family PHTB1_C PF14728.6 KII71399.1 - 0.087 11.9 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 PTHB1 C-terminus zf-Sec23_Sec24 PF04810.15 KII71403.1 - 0.064 13.3 0.5 0.11 12.6 0.5 1.5 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger FLYWCH PF04500.16 KII71404.1 - 0.1 12.7 0.7 0.18 12.0 0.7 1.4 1 0 0 1 1 1 0 FLYWCH zinc finger domain Rad17 PF03215.15 KII71405.1 - 1.8e-05 24.8 5.6 2.1e-05 24.5 0.6 2.8 2 1 1 3 3 3 2 Rad17 P-loop domain AAA_assoc_2 PF16193.5 KII71405.1 - 0.0013 19.1 0.0 0.0096 16.2 0.0 2.3 2 0 0 2 2 2 1 AAA C-terminal domain Utp14 PF04615.13 KII71407.1 - 2.3e-52 178.6 37.2 8.5e-32 110.6 26.4 2.0 2 0 0 2 2 2 2 Utp14 protein DUF4996 PF16387.5 KII71407.1 - 0.017 15.6 2.3 0.043 14.3 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function RNase_HII PF01351.18 KII71407.1 - 2.3 8.0 5.9 0.96 9.2 2.3 2.2 2 0 0 2 2 2 0 Ribonuclease HII CTP_transf_like PF01467.26 KII71408.1 - 2.4e-26 92.6 0.0 4.3e-19 69.1 0.0 2.1 2 0 0 2 2 2 2 Cytidylyltransferase-like DAHP_snth_FXD PF18152.1 KII71408.1 - 0.2 11.5 1.3 0.57 10.1 0.1 2.4 2 2 0 2 2 2 0 DAHP synthase ferredoxin-like domain CM2 PF03021.14 KII71409.1 - 0.024 14.4 0.2 0.036 13.9 0.2 1.3 1 0 0 1 1 1 0 Influenza C virus M2 protein Dimer_Tnp_hAT PF05699.14 KII71409.1 - 0.025 14.3 0.8 0.037 13.8 0.8 1.4 1 1 0 1 1 1 0 hAT family C-terminal dimerisation region Borrelia_REV PF03978.13 KII71411.1 - 0.045 13.7 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein HhH-GPD PF00730.25 KII71412.1 - 1.3e-18 67.4 0.0 1.7e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KII71412.1 - 4.2e-09 35.8 0.0 1e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 KII71412.1 - 0.04 14.5 0.0 0.093 13.4 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_3 PF12836.7 KII71412.1 - 0.067 13.5 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif MeaB PF03308.16 KII71413.1 - 2.2e-75 253.1 0.1 2.8e-75 252.8 0.1 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 KII71413.1 - 5.6e-06 26.4 0.0 4.4e-05 23.5 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 KII71413.1 - 9.4e-06 25.3 1.0 4.4e-05 23.1 1.0 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MnmE_helical PF12631.7 KII71413.1 - 0.00066 19.9 0.1 0.00096 19.4 0.1 1.2 1 0 0 1 1 1 1 MnmE helical domain KAP_NTPase PF07693.14 KII71413.1 - 0.0021 17.4 0.7 0.0075 15.5 0.0 1.9 2 0 0 2 2 2 1 KAP family P-loop domain AAA_10 PF12846.7 KII71413.1 - 0.0059 15.6 0.4 0.011 14.7 0.0 1.7 2 1 0 2 2 2 1 AAA-like domain RsgA_GTPase PF03193.16 KII71413.1 - 0.0066 16.4 3.1 0.017 15.1 0.1 2.8 2 1 1 3 3 3 1 RsgA GTPase AAA_18 PF13238.6 KII71413.1 - 0.023 15.3 0.7 0.058 13.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 KII71413.1 - 0.025 13.8 1.8 0.11 11.7 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.6 KII71413.1 - 0.027 14.8 0.0 0.053 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 KII71413.1 - 0.039 14.3 0.6 0.64 10.4 0.1 2.7 2 1 0 2 2 2 0 RNA helicase AAA PF00004.29 KII71413.1 - 0.045 14.2 0.3 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KII71413.1 - 0.06 13.1 0.0 0.15 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Ribosomal_S20p PF01649.18 KII71413.1 - 0.083 13.5 2.0 0.092 13.4 0.8 1.7 2 0 0 2 2 1 0 Ribosomal protein S20 AAA_22 PF13401.6 KII71413.1 - 0.095 13.0 0.2 0.95 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 KII71413.1 - 0.16 12.0 5.4 0.53 10.3 0.1 2.9 2 1 1 3 3 3 0 Helicase HerA, central domain ABC_tran PF00005.27 KII71413.1 - 0.16 12.4 0.4 0.16 12.4 0.4 2.2 2 1 1 3 3 3 0 ABC transporter Ribosomal_60s PF00428.19 KII71415.1 - 2.1e-13 50.7 0.8 2.5e-13 50.4 0.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein MCPVI PF02993.14 KII71415.1 - 0.06 13.2 0.1 0.069 13.0 0.1 1.1 1 0 0 1 1 1 0 Minor capsid protein VI zf-CCCH_2 PF14608.6 KII71416.1 - 1.4e-12 47.6 52.8 7e-06 26.3 4.1 4.4 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger Nab2p_Zf1 PF18260.1 KII71416.1 - 0.25 11.3 20.6 0.076 12.9 7.7 3.1 3 0 0 3 3 3 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 Pannexin_like PF12534.8 KII71417.1 - 3.5e-07 29.6 0.1 3.5e-07 29.6 0.1 3.1 2 1 1 3 3 3 2 Pannexin-like TM region of LRRC8 Sigma_reg_N PF13800.6 KII71417.1 - 1.9 8.8 9.0 0.74 10.1 4.3 2.9 2 1 0 2 2 2 0 Sigma factor regulator N-terminal DUF2325 PF10087.9 KII71418.1 - 0.053 13.7 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) CytadhesinP1 PF12378.8 KII71418.1 - 0.058 13.6 0.1 0.13 12.5 0.1 1.6 1 1 1 2 2 2 0 Trypsin-sensitive surface-exposed protein ParcG PF10274.9 KII71419.1 - 0.0015 18.7 0.0 0.0016 18.6 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein CbtA_toxin PF06755.12 KII71420.1 - 0.028 14.4 0.0 0.066 13.2 0.0 1.6 2 0 0 2 2 2 0 CbtA_toxin of type IV toxin-antitoxin system LRR_1 PF00560.33 KII71420.1 - 3.5 8.5 7.0 1.5e+02 3.6 0.5 4.8 4 2 0 4 4 4 0 Leucine Rich Repeat MULE PF10551.9 KII71421.1 - 1e-06 29.1 0.4 2.3e-06 27.9 0.2 1.7 2 0 0 2 2 2 1 MULE transposase domain Serpin PF00079.20 KII71422.1 - 2.8e-52 178.2 9.8 3.2e-52 178.1 9.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_3 PF13358.6 KII71423.1 - 0.00027 20.7 0.0 0.00063 19.5 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII71424.1 - 3.5e-11 43.0 0.0 8e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2577 PF10844.8 KII71424.1 - 0.059 13.6 0.0 0.2 11.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2577) R3H-assoc PF13902.6 KII71425.1 - 0.0029 18.0 0.0 0.0039 17.6 0.0 1.3 1 0 0 1 1 1 1 R3H-associated N-terminal domain Leptin PF02024.15 KII71428.1 - 9.4e-05 22.2 1.0 0.00012 21.9 1.0 1.3 1 0 0 1 1 1 1 Leptin Dynamin_M PF01031.20 KII71428.1 - 0.0024 17.2 4.5 0.0032 16.7 4.5 1.1 1 0 0 1 1 1 1 Dynamin central region DUF1664 PF07889.12 KII71428.1 - 0.014 15.4 1.5 0.014 15.4 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2570 PF10828.8 KII71428.1 - 0.023 14.5 1.9 0.023 14.5 1.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) ApoLp-III PF07464.11 KII71428.1 - 0.033 14.3 6.3 0.11 12.6 6.3 1.8 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) CDC37_C PF08564.10 KII71428.1 - 0.041 14.0 1.6 0.061 13.4 1.6 1.4 1 0 0 1 1 1 0 Cdc37 C terminal domain ATP-synt_F6 PF05511.11 KII71428.1 - 0.08 13.4 1.1 4.3 7.8 0.0 2.5 1 1 2 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 DUF948 PF06103.11 KII71428.1 - 0.086 13.1 0.8 0.086 13.1 0.8 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ABC1 PF03109.16 KII71428.1 - 0.091 12.9 1.9 0.18 11.9 0.3 2.1 1 1 0 2 2 2 0 ABC1 family Baculo_PEP_C PF04513.12 KII71428.1 - 0.12 12.4 5.9 0.49 10.4 6.2 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Enkurin PF13864.6 KII71428.1 - 0.12 12.8 9.2 0.85 10.1 0.7 3.4 1 1 1 3 3 3 0 Calmodulin-binding Remorin_C PF03763.13 KII71428.1 - 0.13 12.2 1.6 0.26 11.2 0.8 1.9 1 1 1 2 2 2 0 Remorin, C-terminal region Phage_lysis PF03245.13 KII71428.1 - 0.32 11.1 3.1 4.1 7.5 0.3 2.5 1 1 0 2 2 2 0 Bacteriophage Rz lysis protein Syntaxin_2 PF14523.6 KII71428.1 - 0.38 11.1 10.2 0.51 10.7 3.0 2.5 1 1 1 2 2 2 0 Syntaxin-like protein TolA_bind_tri PF16331.5 KII71428.1 - 0.78 9.9 6.0 0.18 11.9 2.9 1.7 2 0 0 2 2 1 0 TolA binding protein trimerisation Fib_alpha PF08702.10 KII71428.1 - 5.1 7.3 13.1 3.6 7.8 10.7 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family MinE PF03776.14 KII71429.1 - 0.046 13.7 1.2 2.8 8.0 0.2 2.8 2 1 1 3 3 3 0 Septum formation topological specificity factor MinE DUF4599 PF15371.6 KII71429.1 - 0.055 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4599) GlnD_UR_UTase PF08335.11 KII71429.1 - 0.089 12.9 0.1 0.18 11.9 0.1 1.5 1 1 0 1 1 1 0 GlnD PII-uridylyltransferase PgaD PF13994.6 KII71429.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 PgaD-like protein HTH_Tnp_IS630 PF01710.16 KII71431.1 - 7.7e-05 22.7 0.3 9.7e-05 22.4 0.3 1.2 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 KII71431.1 - 0.00012 22.7 0.1 0.00018 22.1 0.1 1.3 1 0 0 1 1 1 1 Homeodomain-like domain PAX PF00292.18 KII71431.1 - 0.00016 21.6 0.0 0.00022 21.2 0.0 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 KII71431.1 - 0.00024 20.8 0.1 0.0089 15.8 0.0 2.6 3 0 0 3 3 3 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII71431.1 - 0.00025 21.2 0.8 0.00048 20.3 0.4 1.6 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.6 KII71431.1 - 0.00029 20.4 0.0 0.00089 18.9 0.0 1.9 1 1 1 2 2 2 1 Winged helix-turn helix HTH_24 PF13412.6 KII71431.1 - 0.00079 18.9 0.5 0.88 9.2 0.0 3.1 3 0 0 3 3 3 2 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 KII71431.1 - 0.00082 19.3 1.0 0.068 13.2 0.0 2.6 1 1 1 2 2 2 1 Crp-like helix-turn-helix domain Arg_repressor PF01316.21 KII71431.1 - 0.092 12.5 1.2 0.17 11.7 1.2 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DUF3921 PF13060.6 KII71431.1 - 0.11 12.5 0.2 1.5 8.9 0.0 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF3921) HTH_28 PF13518.6 KII71431.1 - 0.11 12.6 0.0 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HSP20 PF00011.21 KII71432.1 - 2.1e-25 88.8 8.8 1.7e-15 57.0 3.0 2.0 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII71432.1 - 0.0011 18.5 0.2 0.032 13.8 0.1 2.4 2 1 0 2 2 2 1 HSP20-like domain found in ArsA CsrA PF02599.16 KII71432.1 - 0.041 13.8 0.3 0.37 10.8 0.0 2.5 2 0 0 2 2 2 0 Global regulator protein family CS PF04969.16 KII71432.1 - 0.098 13.7 7.5 1.7 9.7 1.8 2.4 1 1 0 2 2 2 0 CS domain DUF4805 PF16063.5 KII71435.1 - 0.11 11.8 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) DDE_3 PF13358.6 KII71436.1 - 1.7e-27 96.0 0.0 3.2e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII71436.1 - 7.9e-08 32.8 0.0 1.5e-05 25.5 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 KII71436.1 - 5.6e-06 26.0 0.0 7.1e-05 22.5 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain DDE_Tnp_ISAZ013 PF07592.11 KII71436.1 - 0.0042 16.1 0.2 0.64 9.0 0.0 2.5 3 0 0 3 3 3 2 Rhodopirellula transposase DDE domain HTH_Tnp_Tc3_2 PF01498.18 KII71436.1 - 0.019 15.2 0.2 0.27 11.5 0.0 2.5 2 0 0 2 2 2 0 Transposase TrmB PF01978.19 KII71436.1 - 0.021 14.7 0.1 0.045 13.6 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_33 PF13592.6 KII71436.1 - 0.046 13.4 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix IMD PF08397.11 KII71436.1 - 0.049 13.0 0.0 0.49 9.7 0.1 2.1 2 0 0 2 2 2 0 IRSp53/MIM homology domain ApoLp-III PF07464.11 KII71436.1 - 0.096 12.8 0.0 0.21 11.7 0.0 1.6 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) HTH_Tnp_ISL3 PF13542.6 KII71436.1 - 0.14 11.5 0.0 0.39 10.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Ntox50 PF15542.6 KII71436.1 - 1.4 9.8 5.7 3.7e+02 2.0 5.7 3.3 1 1 0 1 1 1 0 Bacterial toxin 50 RT_RNaseH PF17917.1 KII71437.1 - 2.5e-40 137.0 0.0 5.7e-40 135.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71437.1 - 5.8e-36 122.5 0.0 1.4e-35 121.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71437.1 - 1.8e-30 106.1 0.1 3.8e-30 105.1 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII71437.1 - 9.3e-27 93.6 0.0 3.2e-26 91.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71437.1 - 2.2e-17 62.9 5.2 5.6e-17 61.6 2.5 2.8 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII71437.1 - 2.6e-06 27.9 0.0 6.3e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 KII71437.1 - 6.8e-06 25.9 0.6 1.4e-05 24.8 0.6 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII71437.1 - 2.3e-05 24.2 0.0 8.7e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.23 KII71437.1 - 7.2e-05 22.7 9.0 0.033 14.3 1.2 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 KII71437.1 - 8.9e-05 22.2 5.7 0.22 11.4 0.1 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-H2C2 PF09337.10 KII71437.1 - 0.0011 19.1 0.0 0.0081 16.4 0.0 2.5 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII71437.1 - 0.0027 17.4 0.0 0.0078 16.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII71437.1 - 0.017 15.2 0.0 0.051 13.7 0.0 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain zf-CCHC_3 PF13917.6 KII71437.1 - 0.017 15.0 1.6 0.017 15.0 1.6 2.7 1 1 1 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 KII71437.1 - 0.022 15.4 0.0 0.054 14.2 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_2 PF13696.6 KII71437.1 - 0.046 13.5 10.9 0.3 10.9 3.7 2.7 2 0 0 2 2 2 0 Zinc knuckle RVP PF00077.20 KII71437.1 - 0.077 13.3 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 KII71437.1 - 0.34 10.7 6.1 2.4 7.9 0.4 2.7 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.6 KII71438.1 - 4.4e-06 26.5 0.4 1.2e-05 25.1 0.4 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease YEATS PF03366.16 KII71438.1 - 0.017 15.1 0.2 0.022 14.7 0.2 1.2 1 0 0 1 1 1 0 YEATS family Orn_Arg_deC_N PF02784.16 KII71439.1 - 2.5e-76 256.3 0.0 3.2e-76 256.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KII71439.1 - 3.3e-13 49.7 0.0 4.8e-13 49.2 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain XRN_M PF17846.1 KII71440.1 - 9.1e-46 156.7 0.4 3.2e-45 154.9 0.3 1.9 2 0 0 2 2 2 1 Xrn1 helical domain XRN1_D1 PF18332.1 KII71440.1 - 0.026 14.3 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Exoribonuclease Xrn1 D1 domain XRN_N PF03159.18 KII71442.1 - 2.9e-18 66.2 0.4 4.9e-15 55.6 0.0 2.0 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus Dna2 PF08696.11 KII71443.1 - 1.3e-06 28.4 0.0 1.9e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_11 PF13086.6 KII71444.1 - 1.1e-18 68.0 0.1 1.2e-18 67.9 0.1 1.0 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KII71444.1 - 3.6e-09 36.6 0.0 4.1e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KII71444.1 - 2.4e-07 31.2 0.0 3.1e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 KII71444.1 - 6.6e-06 25.9 0.0 7.5e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain UvrD-helicase PF00580.21 KII71444.1 - 0.00065 19.3 0.0 0.00088 18.9 0.0 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA PF00004.29 KII71444.1 - 0.00089 19.7 0.2 0.0011 19.4 0.2 1.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KII71444.1 - 0.0015 17.7 0.1 0.0032 16.6 0.1 1.5 1 1 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 KII71444.1 - 0.0015 18.1 0.0 0.0036 16.8 0.0 1.7 1 1 1 2 2 2 1 P-loop containing dynein motor region ResIII PF04851.15 KII71444.1 - 0.0032 17.5 0.1 0.0037 17.3 0.1 1.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 KII71444.1 - 0.0046 16.4 0.0 0.006 16.0 0.0 1.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI Helicase_RecD PF05127.14 KII71444.1 - 0.0061 16.4 0.0 0.0063 16.4 0.0 1.1 1 0 0 1 1 1 1 Helicase AAA_16 PF13191.6 KII71444.1 - 0.0065 16.9 0.0 0.0076 16.7 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KII71444.1 - 0.012 15.9 0.1 0.017 15.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 KII71444.1 - 0.013 15.2 0.0 0.015 15.0 0.0 1.0 1 0 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.12 KII71444.1 - 0.014 15.2 0.1 0.019 14.7 0.1 1.3 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_31 PF13614.6 KII71444.1 - 0.017 15.1 0.9 0.02 14.8 0.9 1.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KII71444.1 - 0.023 14.4 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PEPCK_ATP PF01293.20 KII71444.1 - 0.026 13.2 0.0 0.032 12.9 0.0 1.2 1 1 0 1 1 1 0 Phosphoenolpyruvate carboxykinase CbiA PF01656.23 KII71444.1 - 0.031 14.3 0.4 0.053 13.6 0.3 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_5 PF07728.14 KII71444.1 - 0.044 13.8 0.1 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF4132 PF13569.6 KII71444.1 - 0.05 13.4 0.0 0.067 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4132) AAA_33 PF13671.6 KII71444.1 - 0.054 13.7 0.0 0.063 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KII71444.1 - 0.057 13.9 0.1 0.07 13.6 0.1 1.3 1 1 0 1 1 1 0 ABC transporter ArsA_ATPase PF02374.15 KII71444.1 - 0.072 12.3 0.2 0.12 11.6 0.1 1.3 1 1 0 1 1 1 0 Anion-transporting ATPase DUF815 PF05673.13 KII71444.1 - 0.081 12.1 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SMC_N PF02463.19 KII71444.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_24 PF13479.6 KII71444.1 - 0.22 11.2 1.0 0.3 10.8 1.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KII71444.1 - 0.32 11.4 3.6 0.84 10.1 3.6 1.8 1 1 0 1 1 1 0 AAA domain AAA_12 PF13087.6 KII71445.1 - 6.2e-43 146.7 0.0 7.6e-43 146.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KII71445.1 - 2.4e-06 27.5 0.0 3.6e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KII71445.1 - 0.00037 20.3 0.0 0.38 10.5 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Propeptide_C25 PF08126.11 KII71445.1 - 0.083 12.0 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Propeptide_C25 gerPA PF10676.9 KII71445.1 - 0.094 13.0 0.0 0.62 10.3 0.0 2.2 2 0 0 2 2 2 0 Spore germination protein gerPA/gerPF SH3_9 PF14604.6 KII71446.1 - 4.9e-12 45.5 0.0 2.4e-09 36.9 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KII71446.1 - 4e-11 42.4 0.2 9.7e-08 31.5 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 KII71446.1 - 6.6e-08 32.1 0.1 1e-05 25.1 0.0 2.4 2 1 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 KII71446.1 - 0.015 15.5 0.5 2 8.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial SH3 domain SH3_6 PF12913.7 KII71446.1 - 0.039 13.5 0.0 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 SH3 domain (SH3b1 type) Ribosomal_L40e PF01020.17 KII71449.1 - 1.8e-24 85.4 9.9 2.6e-24 84.9 9.9 1.3 1 0 0 1 1 1 1 Ribosomal L40e family ubiquitin PF00240.23 KII71449.1 - 1.1e-09 37.9 0.0 1.6e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KII71449.1 - 9.5e-08 31.8 0.0 1.4e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TUG-UBL1 PF11470.8 KII71449.1 - 0.012 15.9 0.0 0.031 14.5 0.0 1.7 1 1 0 1 1 1 0 TUG ubiquitin-like domain Fer2_3 PF13085.6 KII71449.1 - 1.3 9.0 5.2 11 6.1 0.1 2.2 1 1 1 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Abhydrolase_2 PF02230.16 KII71450.1 - 1.9e-06 27.8 0.3 2.1e-06 27.7 0.3 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 KII71450.1 - 0.0081 15.7 0.2 0.0093 15.5 0.2 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 KII71450.1 - 0.044 13.2 0.1 0.05 13.1 0.1 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase family HTH_23 PF13384.6 KII71451.1 - 2.1e-05 24.2 0.1 0.0001 22.0 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII71451.1 - 0.00041 20.5 0.0 0.033 14.4 0.0 2.5 2 0 0 2 2 2 1 Transposase PAX PF00292.18 KII71451.1 - 0.00055 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 'Paired box' domain HTH_28 PF13518.6 KII71451.1 - 0.0028 17.7 0.0 0.0054 16.8 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 KII71451.1 - 0.0059 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 KII71451.1 - 0.013 15.5 0.0 0.064 13.3 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix CRIC_ras_sig PF10534.9 KII71451.1 - 0.036 14.2 0.0 0.1 12.8 0.0 1.8 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras HTH_29 PF13551.6 KII71451.1 - 0.038 14.0 0.0 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix HTH_psq PF05225.16 KII71451.1 - 0.082 12.7 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Phage_CI_repr PF07022.13 KII71451.1 - 0.2 11.8 0.0 0.57 10.3 0.0 1.7 2 0 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain Piwi PF02171.17 KII71452.1 - 7.5e-55 186.3 0.1 8.4e-55 186.1 0.1 1.0 1 0 0 1 1 1 1 Piwi domain UCH PF00443.29 KII71452.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DUF5391 PF17369.2 KII71453.1 - 0.018 15.1 1.8 0.027 14.5 1.8 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5391) HTH_23 PF13384.6 KII71455.1 - 0.00011 21.8 0.5 0.029 14.2 0.0 2.6 3 0 0 3 3 3 2 Homeodomain-like domain HTH_32 PF13565.6 KII71455.1 - 0.00022 21.8 0.1 0.00099 19.7 0.0 1.9 1 1 1 2 2 2 1 Homeodomain-like domain PAX PF00292.18 KII71455.1 - 0.0013 18.7 0.3 0.0015 18.4 0.3 1.1 1 0 0 1 1 1 1 'Paired box' domain TrmB PF01978.19 KII71455.1 - 0.0043 16.9 0.0 0.0066 16.3 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF3634 PF12321.8 KII71455.1 - 0.013 15.8 0.1 0.016 15.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3634) TnsD PF15978.5 KII71455.1 - 0.024 13.6 0.1 0.028 13.4 0.1 1.0 1 0 0 1 1 1 0 Tn7-like transposition protein D DUF359 PF04019.12 KII71455.1 - 0.025 14.2 0.6 0.033 13.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF359) HTH_28 PF13518.6 KII71455.1 - 0.035 14.2 0.0 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 KII71455.1 - 0.078 12.6 1.1 0.11 12.2 0.1 1.7 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.6 KII71455.1 - 0.084 12.9 0.7 0.11 12.6 0.0 1.5 2 0 0 2 2 2 0 Winged helix-turn helix HTH_3 PF01381.22 KII71455.1 - 0.13 12.4 0.0 0.53 10.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix Ig_J_chain PF15097.6 KII71456.1 - 0.014 15.3 0.5 0.019 14.8 0.5 1.4 1 0 0 1 1 1 0 Immunoglobulin J chain DUF4441 PF14536.6 KII71457.1 - 0.46 10.7 12.6 0.46 10.7 10.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4441) Nuc_N PF14448.6 KII71459.1 - 0.042 13.7 0.1 0.094 12.6 0.1 1.6 1 0 0 1 1 1 0 Nuclease N terminal PalH PF08733.10 KII71459.1 - 0.17 10.9 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 PalH/RIM21 HAD_SAK_2 PF18143.1 KII71462.1 - 1.7 8.9 5.6 35 4.7 5.6 2.0 1 1 0 1 1 1 0 HAD domain in Swiss Army Knife RNA repair proteins Presenilin PF01080.17 KII71462.1 - 7.5 5.2 7.0 9.2 4.9 7.0 1.2 1 0 0 1 1 1 0 Presenilin AKAP95 PF04988.12 KII71464.1 - 0.0016 18.7 0.7 0.0016 18.7 0.7 2.1 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) zf-H2C2_5 PF13909.6 KII71464.1 - 0.044 13.5 0.2 0.044 13.5 0.2 3.9 4 1 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 KII71464.1 - 0.065 14.1 14.0 2 9.5 1.4 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger EndIII_4Fe-2S PF10576.9 KII71465.1 - 0.21 11.9 3.4 0.43 11.0 3.4 1.5 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III TMEM154 PF15102.6 KII71468.1 - 0.0053 16.7 0.0 0.0069 16.3 0.0 1.1 1 0 0 1 1 1 1 TMEM154 protein family zf-C2H2_4 PF13894.6 KII71470.1 - 0.00012 22.6 3.2 2.4 9.2 0.1 3.8 3 1 1 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 KII71470.1 - 0.0047 17.3 5.5 0.17 12.4 0.1 3.7 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 KII71470.1 - 0.012 15.3 3.6 0.014 15.1 0.0 2.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 KII71470.1 - 0.059 13.7 1.1 0.1 12.9 0.2 1.8 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 KII71470.1 - 0.095 13.2 1.2 1.2 9.7 0.1 2.3 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_2 PF13465.6 KII71470.1 - 6.6 7.4 9.0 24 5.6 0.2 3.7 4 0 0 4 4 4 0 Zinc-finger double domain Ldl_recept_a PF00057.18 KII71471.1 - 6.1e-43 144.7 126.2 2.4e-10 40.5 12.3 7.7 7 0 0 7 7 7 7 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KII71471.1 - 1e-07 31.1 0.3 1.8e-07 30.3 0.3 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII71471.1 - 0.38 10.9 1.3 1.1 9.5 0.3 2.4 2 0 0 2 2 2 0 BNR/Asp-box repeat zf-UBR PF02207.20 KII71475.1 - 7.2e-10 38.9 13.4 7.2e-10 38.9 13.4 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) B2-adapt-app_C PF09066.10 KII71475.1 - 0.13 12.4 0.3 5.8 7.1 0.1 2.6 2 0 0 2 2 2 0 Beta2-adaptin appendage, C-terminal sub-domain Ribo_biogen_C PF04034.13 KII71478.1 - 0.0003 20.5 0.0 0.00042 20.0 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal Sortilin-Vps10 PF15902.5 KII71478.1 - 0.0012 17.7 0.3 0.0017 17.2 0.3 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, FemAB PF02388.16 KII71479.1 - 0.062 12.2 0.1 0.08 11.8 0.1 1.1 1 0 0 1 1 1 0 FemAB family Pox_E8 PF03394.13 KII71479.1 - 0.18 11.3 0.0 0.25 10.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus E8 protein RVP PF00077.20 KII71480.1 - 0.00021 21.5 0.0 0.00027 21.2 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII71480.1 - 0.041 14.5 0.0 0.075 13.7 0.0 1.5 1 1 0 1 1 1 0 Aspartyl protease DUF3907 PF13047.6 KII71481.1 - 0.048 13.6 0.1 0.052 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) SNAP PF14938.6 KII71482.1 - 0.0011 18.5 1.8 0.0013 18.2 1.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 KII71482.1 - 0.0066 16.2 3.7 6.1 6.8 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII71482.1 - 0.045 14.0 3.4 13 6.3 0.1 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII71482.1 - 0.055 13.6 1.4 24 5.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DDE_3 PF13358.6 KII71483.1 - 3.6e-07 30.0 0.0 5e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DEAD PF00270.29 KII71484.1 - 3.2e-45 154.0 0.0 5.9e-45 153.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII71484.1 - 4.1e-25 88.3 0.0 1.8e-24 86.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII71484.1 - 1.5e-08 34.9 0.0 3.1e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KII71484.1 - 0.12 12.6 0.0 0.45 10.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain DUF3322 PF11795.8 KII71484.1 - 0.16 12.0 0.0 3.2 7.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Cofilin_ADF PF00241.20 KII71485.1 - 5.6e-28 97.2 0.3 6.4e-28 97.0 0.3 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Phage_TAC_4 PF08748.11 KII71485.1 - 0.072 13.4 0.1 0.13 12.6 0.0 1.5 2 0 0 2 2 2 0 Phage tail assembly chaperone PAC2 PF09754.9 KII71486.1 - 0.026 14.5 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 PAC2 family Phage_int_SAM_3 PF14659.6 KII71486.1 - 0.033 14.4 0.2 9.8 6.5 0.0 2.6 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain RNase_P_p30 PF01876.16 KII71487.1 - 6.5e-38 130.4 0.1 8.5e-38 130.0 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit p30 Ribosomal_L13 PF00572.18 KII71488.1 - 1.1e-08 35.3 0.2 1.3e-06 28.6 0.2 2.4 1 1 0 1 1 1 1 Ribosomal protein L13 DUF5084 PF16894.5 KII71490.1 - 0.0035 17.8 0.1 0.017 15.5 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5084) PhosphMutase PF10143.9 KII71490.1 - 0.093 12.6 0.0 0.14 12.0 0.0 1.3 1 1 0 1 1 1 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase DUF4577 PF15145.6 KII71491.1 - 0.02 14.9 0.0 0.053 13.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) TMEM135_C_rich PF15982.5 KII71493.1 - 0.13 12.9 0.7 1.7 9.2 0.2 2.1 2 0 0 2 2 2 0 N-terminal cysteine-rich region of Transmembrane protein 135 C1_2 PF03107.16 KII71494.1 - 0.013 15.8 0.4 0.84 10.0 0.1 2.6 2 0 0 2 2 2 0 C1 domain Stevor PF17410.2 KII71494.1 - 0.05 13.2 0.3 0.082 12.4 0.0 1.5 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame HPIH PF13323.6 KII71494.1 - 0.1 12.4 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 N-terminal domain with HPIH motif DUF547 PF04784.14 KII71497.1 - 0.039 14.0 0.2 0.074 13.1 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF547 DDE_Tnp_IS1595 PF12762.7 KII71499.1 - 3.4e-14 53.1 0.0 4.8e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Annexin PF00191.20 KII71500.1 - 2.1e-05 24.5 0.4 0.0046 17.0 0.2 2.2 2 0 0 2 2 2 2 Annexin Annexin PF00191.20 KII71501.1 - 0.036 14.2 0.0 2.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Annexin Annexin PF00191.20 KII71502.1 - 9.9e-22 76.8 3.1 3.1e-08 33.6 0.1 4.3 4 1 0 4 4 4 4 Annexin Ntox8 PF15545.6 KII71502.1 - 0.11 12.6 0.0 0.53 10.4 0.0 2.0 2 0 0 2 2 2 0 Bacterial toxin 8 ABC_tran PF00005.27 KII71503.1 - 2.7e-05 24.7 0.0 3.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KII71503.1 - 0.042 13.3 0.0 0.055 12.9 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ACTH_domain PF00976.18 KII71505.1 - 1.5 8.8 5.6 2.7 8.0 5.6 1.4 1 0 0 1 1 1 0 Corticotropin ACTH domain Ovate PF04844.13 KII71507.1 - 0.078 13.0 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Transcriptional repressor, ovate IBN_N PF03810.19 KII71508.1 - 0.0011 18.8 0.8 0.056 13.4 0.2 2.4 2 0 0 2 2 2 2 Importin-beta N-terminal domain Com_YlbF PF06133.11 KII71508.1 - 0.1 13.2 2.1 13 6.5 0.1 3.0 2 1 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Frag1 PF10277.9 KII71509.1 - 0.0013 18.4 6.9 0.0016 18.0 6.9 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF2621 PF11084.8 KII71509.1 - 0.0078 16.2 0.2 0.013 15.4 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2621) MatE PF01554.18 KII71509.1 - 0.021 14.5 3.9 0.025 14.2 3.9 1.1 1 0 0 1 1 1 0 MatE Ldl_recept_a PF00057.18 KII71511.1 - 1.7e-07 31.4 8.5 2.2e-07 30.9 8.5 1.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Imm39 PF15568.6 KII71512.1 - 0.034 14.2 0.1 0.073 13.2 0.1 1.5 1 0 0 1 1 1 0 Immunity protein 39 Sipho_Gp157 PF05565.11 KII71512.1 - 0.072 13.1 1.3 5.2 7.1 0.2 2.3 2 0 0 2 2 2 0 Siphovirus Gp157 APG5 PF04106.12 KII71512.1 - 0.1 12.2 0.7 0.16 11.5 0.6 1.6 1 1 0 1 1 1 0 Autophagy protein Apg5 F420_oxidored PF03807.17 KII71513.1 - 0.021 15.4 0.0 0.036 14.6 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent F420_oxidored PF03807.17 KII71514.1 - 1.4e-17 64.1 0.0 2.2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 KII71514.1 - 4.1e-10 40.1 0.0 7.2e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 KII71514.1 - 3.8e-05 23.4 0.2 5.7e-05 22.8 0.2 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 KII71514.1 - 0.00016 21.1 0.1 0.00035 20.0 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KII71514.1 - 0.0017 18.0 0.0 0.0089 15.6 0.1 1.9 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 KII71514.1 - 0.004 17.2 0.0 0.0057 16.7 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 KII71514.1 - 0.005 16.7 0.1 0.009 15.9 0.1 1.4 1 0 0 1 1 1 1 Rossmann-like domain UDPG_MGDP_dh_N PF03721.14 KII71514.1 - 0.0059 16.2 0.3 0.011 15.4 0.2 1.5 1 1 1 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 KII71514.1 - 0.0065 16.5 0.4 0.049 13.6 0.4 2.0 1 1 1 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GFO_IDH_MocA PF01408.22 KII71514.1 - 0.008 17.0 0.0 0.36 11.7 0.1 2.3 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold TrkA_N PF02254.18 KII71514.1 - 0.014 15.6 0.4 0.034 14.4 0.2 1.7 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 KII71514.1 - 0.016 15.7 0.0 0.026 15.0 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_10 PF13460.6 KII71514.1 - 0.023 14.6 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding 3HCDH_N PF02737.18 KII71514.1 - 0.034 14.0 0.2 0.051 13.5 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DpaA_N PF16924.5 KII71514.1 - 0.066 13.3 0.0 0.16 12.0 0.0 1.6 2 0 0 2 2 1 0 Dipicolinate synthase subunit A N-terminal domain Pyr_redox PF00070.27 KII71514.1 - 0.069 13.7 0.3 0.16 12.6 0.3 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HxlR PF01638.17 KII71515.1 - 1e-28 99.0 0.3 1.3e-28 98.6 0.3 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 KII71515.1 - 0.0021 18.0 0.0 0.0037 17.2 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_5 PF01022.20 KII71515.1 - 0.014 15.2 0.1 0.029 14.2 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR PF01047.22 KII71515.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 MarR family RVT_1 PF00078.27 KII71518.1 - 1.2e-19 70.7 0.0 2.3e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII71519.1 - 9.8e-05 22.6 0.0 0.00025 21.3 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71520.1 - 4.2e-05 23.2 0.1 9.1e-05 22.1 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) THDPS_N PF14790.6 KII71521.1 - 0.0019 18.1 0.7 0.0021 17.9 0.7 1.0 1 0 0 1 1 1 1 Tetrahydrodipicolinate N-succinyltransferase N-terminal Nucleoside_tran PF01733.18 KII71522.1 - 3.9e-06 26.5 0.3 3.9e-06 26.5 0.3 1.9 1 1 0 2 2 2 1 Nucleoside transporter TMEM100 PF16311.5 KII71522.1 - 0.091 12.3 2.4 0.11 12.0 1.6 1.6 1 1 0 1 1 1 0 Transmembrane protein 100 rve PF00665.26 KII71526.1 - 9.7e-20 70.9 0.0 1.8e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71526.1 - 2.6e-17 62.7 0.8 4.4e-17 61.9 0.8 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII71526.1 - 0.0034 17.1 0.0 0.01 15.6 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain CxC3 PF18804.1 KII71526.1 - 0.026 14.4 0.3 0.08 12.8 0.1 1.9 2 1 0 2 2 2 0 CxC3 like cysteine cluster associated with KDZ transposases APG17 PF04108.12 KII71528.1 - 0.01 15.0 1.2 0.011 14.8 1.2 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 Carbpep_Y_N PF05388.11 KII71528.1 - 0.052 14.1 0.2 0.28 11.7 0.0 1.9 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide Crisp PF08562.10 KII71528.1 - 0.35 11.5 3.1 6.8 7.4 0.8 2.3 2 0 0 2 2 2 0 Crisp Homez PF11569.8 KII71529.1 - 0.0009 18.7 0.0 0.0019 17.6 0.0 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Homeodomain PF00046.29 KII71529.1 - 0.072 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Homeodomain DUF281 PF03436.13 KII71529.1 - 0.083 13.3 2.7 0.25 11.8 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF281) rve PF00665.26 KII71530.1 - 0.00019 21.6 0.0 0.00054 20.1 0.0 1.8 1 1 1 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII71530.1 - 0.00061 19.5 0.0 0.0013 18.4 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH PF17917.1 KII71531.1 - 1.8e-31 108.5 0.0 2.5e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71531.1 - 3.7e-28 97.5 0.0 5.1e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71532.1 - 7.4e-17 61.6 0.1 1.3e-16 60.8 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_20 PF12840.7 KII71532.1 - 0.078 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain RPN6_N PF18055.1 KII71534.1 - 1.8e-20 73.5 0.3 5e-20 72.0 0.3 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 KII71534.1 - 3.5e-16 59.6 1.3 9.9e-16 58.2 0.1 2.4 3 1 0 3 3 3 1 PCI domain TPR_MalT PF17874.1 KII71534.1 - 9.8e-05 21.9 0.0 0.00022 20.7 0.0 1.4 1 1 0 1 1 1 1 MalT-like TPR region TPR_12 PF13424.6 KII71534.1 - 0.0027 18.0 0.3 0.11 12.8 0.0 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KII71534.1 - 0.029 14.5 0.3 27 5.2 0.3 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 KII71534.1 - 0.087 12.2 1.7 0.42 10.0 0.2 2.3 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 KII71534.1 - 0.36 11.0 1.7 4.7 7.5 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1581 PF07619.11 KII71535.1 - 0.05 13.8 0.2 1.6 8.9 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1581) DDE_Tnp_IS1595 PF12762.7 KII71535.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 1 1 0 1 1 1 0 ISXO2-like transposase domain BBS2_Mid PF14783.6 KII71536.1 - 0.0023 18.0 0.0 0.8 9.8 0.0 2.4 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Ldl_recept_a PF00057.18 KII71537.1 - 8.1e-51 170.0 126.9 1.2e-10 41.4 9.6 9.5 9 0 0 9 9 9 7 Low-density lipoprotein receptor domain class A MMR_HSR1 PF01926.23 KII71538.1 - 2.6e-17 62.9 0.0 5.7e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 KII71538.1 - 5.2e-11 42.9 0.3 3.8e-06 27.1 0.0 2.4 1 1 1 2 2 2 2 Dynamin family FeoB_N PF02421.18 KII71538.1 - 7.8e-10 38.5 0.0 1.4e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KII71538.1 - 7.5e-05 22.7 0.3 0.11 12.4 0.1 2.7 2 1 0 2 2 2 2 RsgA GTPase MeaB PF03308.16 KII71538.1 - 0.0013 17.8 0.0 0.088 11.8 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 KII71538.1 - 0.0034 16.7 0.0 0.0056 16.0 0.0 1.3 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 KII71538.1 - 0.0067 16.0 0.0 0.5 9.9 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 KII71538.1 - 0.014 14.6 0.6 13 4.8 0.0 3.1 3 0 0 3 3 3 0 G-protein alpha subunit Roc PF08477.13 KII71538.1 - 0.032 14.5 0.0 0.53 10.5 0.0 2.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 KII71538.1 - 0.037 14.5 0.0 0.069 13.7 0.0 1.4 1 1 0 1 1 1 0 ABC transporter RRM_1 PF00076.22 KII71539.1 - 5.4e-05 22.9 0.3 0.48 10.3 0.0 3.2 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) T6SS_VasJ PF16989.5 KII71539.1 - 0.09 12.2 0.6 0.13 11.7 0.6 1.2 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ SbsC_C PF18058.1 KII71539.1 - 0.46 10.7 5.2 0.87 9.8 5.2 1.4 1 0 0 1 1 1 0 SbsC C-terminal domain tRNA-synt_1b PF00579.25 KII71541.1 - 0.017 14.5 0.3 0.024 14.0 0.3 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Rep_fac_C PF08542.11 KII71541.1 - 0.042 14.3 0.1 0.16 12.4 0.1 2.1 2 0 0 2 2 2 0 Replication factor C C-terminal domain DBP10CT PF08147.12 KII71543.1 - 0.018 15.3 0.5 0.046 14.0 0.5 1.7 1 0 0 1 1 1 0 DBP10CT (NUC160) domain MULE PF10551.9 KII71544.1 - 0.11 12.9 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 MULE transposase domain RNA_pol_Rpb5_C PF01191.19 KII71545.1 - 5.8e-34 115.8 0.1 1.2e-33 114.8 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 KII71545.1 - 2e-28 98.8 0.3 4e-28 97.8 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain IBN_N PF03810.19 KII71546.1 - 0.088 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Importin-beta N-terminal domain UME PF08064.13 KII71546.1 - 0.1 12.5 0.2 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 UME (NUC010) domain IFRD PF05004.13 KII71548.1 - 4.8e-06 25.9 0.3 0.012 14.7 0.2 2.3 2 0 0 2 2 2 2 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 KII71548.1 - 2e-05 24.9 0.0 0.15 12.5 0.0 3.6 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 KII71548.1 - 0.0029 17.7 3.3 0.089 13.1 0.0 4.1 5 0 0 5 5 5 1 HEAT repeat Vac14_Fab1_bd PF12755.7 KII71548.1 - 0.061 13.9 1.5 15 6.2 0.1 3.2 2 2 1 3 3 3 0 Vacuolar 14 Fab1-binding region IFRD PF05004.13 KII71550.1 - 1.3e-07 31.1 0.8 0.011 14.8 0.0 2.3 2 0 0 2 2 2 2 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 KII71550.1 - 6.6e-05 23.2 0.0 0.5 10.8 0.0 3.7 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 KII71550.1 - 0.0048 17.0 7.4 0.017 15.3 0.0 4.7 7 0 0 7 7 7 1 HEAT repeat Condensin2nSMC PF12422.8 KII71550.1 - 0.097 12.8 0.4 4.9 7.3 0.1 2.7 2 1 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit HEAT_EZ PF13513.6 KII71550.1 - 0.11 13.1 0.1 9.1 6.9 0.0 3.5 4 1 0 4 4 4 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 KII71550.1 - 0.15 12.7 2.6 12 6.6 0.1 3.2 2 2 1 3 3 3 0 Vacuolar 14 Fab1-binding region zf-C3HC4_5 PF17121.5 KII71551.1 - 0.092 12.6 0.9 7.9 6.4 0.2 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CD34_antigen PF06365.12 KII71552.1 - 0.059 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family TraL PF07178.11 KII71552.1 - 0.084 13.4 0.0 0.42 11.1 0.0 2.1 3 0 0 3 3 3 0 TraL protein Integrin_beta PF00362.18 KII71553.1 - 3.7e-31 108.7 0.1 6.1e-31 108.0 0.1 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain EGF_2 PF07974.13 KII71553.1 - 1.8e-06 28.2 32.7 0.00045 20.5 14.4 3.3 2 0 0 2 2 2 2 EGF-like domain I-EGF_1 PF18372.1 KII71553.1 - 0.017 15.2 7.4 0.017 15.2 7.4 3.3 3 0 0 3 3 3 0 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 KII71553.1 - 1.9 8.6 17.1 0.41 10.7 2.5 3.1 3 0 0 3 3 3 0 Tenascin EGF domain rve PF00665.26 KII71554.1 - 9.8e-19 67.7 0.0 1.5e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71554.1 - 3.7e-15 55.8 0.8 7.2e-15 54.8 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII71554.1 - 0.0012 18.6 0.0 0.0045 16.7 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII71554.1 - 0.14 12.4 0.1 0.29 11.4 0.1 1.6 1 0 0 1 1 1 0 H2C2 zinc finger DDE_Tnp_IS1595 PF12762.7 KII71555.1 - 3.9e-13 49.7 0.1 4.8e-13 49.4 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain RIF5_SNase_2 PF18189.1 KII71555.1 - 0.035 13.9 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 TbRIF5 SNase domain 2 zf-C2H2_jaz PF12171.8 KII71556.1 - 0.13 12.6 2.6 1.6 9.1 0.5 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Sortilin-Vps10 PF15902.5 KII71559.1 - 7.9e-13 48.0 1.3 1.7e-07 30.4 0.1 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII71559.1 - 8.8e-06 25.0 1.2 0.13 12.3 0.1 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat RT_RNaseH PF17917.1 KII71562.1 - 1.4e-12 47.8 0.0 2.3e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71562.1 - 7.2e-05 22.8 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 KII71562.1 - 0.0038 17.0 0.0 0.012 15.4 0.0 1.7 2 1 0 2 2 2 1 Reverse transcriptase-like DUF4371 PF14291.6 KII71567.1 - 0.011 15.4 0.3 0.018 14.7 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) DDE_3 PF13358.6 KII71569.1 - 4.3e-18 65.5 0.1 4.8e-18 65.3 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Adap_comp_sub PF00928.21 KII71569.1 - 0.1 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Adaptor complexes medium subunit family HTH_32 PF13565.6 KII71570.1 - 0.0025 18.4 0.0 0.036 14.7 0.0 2.2 1 1 0 1 1 1 1 Homeodomain-like domain HTH_33 PF13592.6 KII71570.1 - 0.0062 16.2 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.6 KII71570.1 - 0.022 14.5 0.4 9.1 6.1 0.0 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain Baculo_ODV-E27 PF05314.11 KII71570.1 - 0.036 13.3 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 Syntaxin_2 PF14523.6 KII71570.1 - 0.076 13.4 0.9 0.51 10.7 0.1 2.2 2 1 0 2 2 2 0 Syntaxin-like protein PufQ PF05398.11 KII71575.1 - 0.11 12.6 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 PufQ cytochrome subunit DUF2269 PF10027.9 KII71576.1 - 0.019 15.0 3.1 0.035 14.2 3.1 1.4 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) AIG1 PF04548.16 KII71576.1 - 0.065 12.5 0.0 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 AIG1 family FtsL PF04999.13 KII71576.1 - 0.079 13.0 0.5 0.079 13.0 0.5 2.5 2 1 1 3 3 3 0 Cell division protein FtsL AA_permease PF00324.21 KII71576.1 - 0.12 10.9 9.9 0.058 12.0 5.6 2.3 1 1 1 2 2 2 0 Amino acid permease ICMT PF04140.14 KII71576.1 - 0.15 12.5 7.2 0.14 12.6 1.6 2.4 1 1 1 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF4494 PF14902.6 KII71579.1 - 0.048 13.5 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4494) zinc_ribbon_2 PF13240.6 KII71579.1 - 0.096 12.4 4.8 6.3 6.7 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-CCHC PF00098.23 KII71579.1 - 0.16 12.1 7.8 0.55 10.4 1.9 2.5 2 0 0 2 2 2 0 Zinc knuckle DZR PF12773.7 KII71579.1 - 1.5 8.9 6.1 7.4 6.7 6.1 2.1 1 1 0 1 1 1 0 Double zinc ribbon rve PF00665.26 KII71580.1 - 6.2e-13 49.0 0.0 9.6e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII71580.1 - 0.00074 19.3 0.1 0.0017 18.1 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain HTH_33 PF13592.6 KII71583.1 - 6.7e-07 28.9 0.1 1.5e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII71583.1 - 0.0071 16.6 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 KII71583.1 - 0.028 15.0 0.0 0.044 14.4 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Peptidase_U40 PF10464.9 KII71586.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase U40 DCAF15_WD40 PF14939.6 KII71587.1 - 0.054 13.2 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat Phage_tail_T PF06223.12 KII71588.1 - 0.12 12.9 0.0 0.17 12.4 0.0 1.2 1 0 0 1 1 1 0 Minor tail protein T RT_RNaseH PF17917.1 KII71590.1 - 1.1e-38 131.7 0.0 3.5e-38 130.1 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71590.1 - 5.5e-35 119.4 0.3 2.5e-34 117.3 0.0 2.3 3 0 0 3 3 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71590.1 - 7.9e-27 94.2 0.1 2e-26 92.9 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII71590.1 - 5.9e-25 87.8 0.0 2.3e-24 85.9 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71590.1 - 2.4e-17 62.8 0.2 1e-16 60.8 0.2 2.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 KII71590.1 - 6.3e-06 26.0 11.2 0.0024 17.9 2.0 2.7 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII71590.1 - 3.8e-05 23.9 0.0 0.00019 21.7 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII71590.1 - 0.00034 21.2 0.0 0.00086 19.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII71590.1 - 0.00043 20.8 0.0 0.001 19.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII71590.1 - 0.0014 18.4 0.1 0.0037 17.1 0.1 1.7 1 1 0 1 1 1 1 Aspartyl protease rve_3 PF13683.6 KII71590.1 - 0.0041 16.9 0.0 0.013 15.2 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.11 KII71590.1 - 0.0056 16.5 0.3 0.012 15.4 0.3 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.6 KII71590.1 - 0.0097 15.9 5.9 0.025 14.6 0.5 2.5 1 1 1 2 2 2 1 Zinc knuckle zf-H2C2 PF09337.10 KII71590.1 - 0.086 13.1 0.8 0.36 11.1 0.1 2.5 2 0 0 2 2 2 0 H2C2 zinc finger Herpes_UL14 PF03580.14 KII71590.1 - 0.091 13.0 0.8 0.17 12.1 0.0 1.8 2 0 0 2 2 1 0 Herpesvirus UL14-like protein Zn_Tnp_IS91 PF14319.6 KII71590.1 - 0.56 10.3 7.9 0.38 10.8 3.7 2.9 2 0 0 2 2 2 0 Transposase zinc-binding domain PHD_4 PF16866.5 KII71590.1 - 8.1 6.6 7.3 1.3 9.2 1.3 2.8 3 1 1 4 4 4 0 PHD-finger ECH_2 PF16113.5 KII71591.1 - 1.6e-60 205.4 0.0 1.8e-60 205.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KII71591.1 - 2.3e-20 73.0 0.0 1.2e-18 67.4 0.0 2.7 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase TypeIII_RM_meth PF12564.8 KII71592.1 - 0.15 12.2 1.9 5.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit HLH PF00010.26 KII71593.1 - 2.4e-11 43.4 6.4 3.3e-10 39.7 1.5 2.9 3 0 0 3 3 3 2 Helix-loop-helix DNA-binding domain TEX12 PF15219.6 KII71593.1 - 0.16 12.3 1.1 11 6.4 0.1 2.3 2 0 0 2 2 2 0 Testis-expressed 12 Pkinase PF00069.25 KII71594.1 - 1.1e-46 159.3 0.3 3.1e-46 157.9 0.3 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII71594.1 - 2e-27 96.1 0.0 3.2e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII71594.1 - 3.6e-05 23.2 0.0 0.00014 21.3 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KII71594.1 - 0.0035 16.7 0.2 0.0084 15.5 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KII71594.1 - 0.089 12.4 5.3 0.029 14.0 1.2 2.2 2 1 0 2 2 2 0 Choline/ethanolamine kinase XPG_I PF00867.18 KII71596.1 - 2.3e-22 79.1 0.1 6.8e-22 77.6 0.0 1.7 2 0 0 2 2 2 1 XPG I-region SAM_4 PF18017.1 KII71596.1 - 0.0074 16.2 0.0 0.02 14.8 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 KII71597.1 - 0.002 18.4 0.1 0.0033 17.7 0.1 1.3 1 0 0 1 1 1 1 PDZ domain L27 PF02828.16 KII71597.1 - 0.0034 17.1 0.1 0.0061 16.3 0.1 1.4 1 0 0 1 1 1 1 L27 domain YfmQ PF10787.9 KII71598.1 - 0.032 14.0 0.3 0.058 13.2 0.3 1.5 1 1 0 1 1 1 0 Uncharacterised protein from bacillus cereus group MutS_II PF05188.17 KII71599.1 - 0.00068 19.9 0.1 0.00088 19.6 0.1 1.2 1 0 0 1 1 1 1 MutS domain II Myosin_head PF00063.21 KII71601.1 - 2.2e-238 792.9 1.3 3.1e-238 792.4 1.3 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KII71601.1 - 5.8e-16 58.7 0.9 1.3e-15 57.6 0.9 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding AAA_22 PF13401.6 KII71601.1 - 0.01 16.1 0.3 0.043 14.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KII71601.1 - 0.02 15.3 0.0 0.045 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KII71601.1 - 0.079 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase SH3_1 PF00018.28 KII71602.1 - 8e-18 63.8 0.3 1.3e-17 63.1 0.3 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KII71602.1 - 1.1e-16 60.3 0.1 1.7e-16 59.8 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KII71602.1 - 2.9e-15 55.7 0.0 4.5e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Myosin_TH1 PF06017.13 KII71602.1 - 2.1e-05 24.3 1.4 3.3e-05 23.6 1.3 1.5 1 1 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding DUF5348 PF17295.2 KII71602.1 - 0.011 15.7 0.1 0.039 13.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5348) Agenet PF05641.12 KII71602.1 - 0.22 12.0 0.5 33 5.0 0.1 3.0 3 0 0 3 3 3 0 Agenet domain DDE_Tnp_IS1595 PF12762.7 KII71603.1 - 3e-13 50.0 0.0 3.5e-13 49.8 0.0 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain Homeodomain PF00046.29 KII71605.1 - 1.8e-15 56.5 6.5 4e-15 55.4 6.5 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KII71605.1 - 0.012 15.5 3.2 0.031 14.2 3.2 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 KII71605.1 - 0.033 13.7 0.0 0.084 12.4 0.0 1.7 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez MSA-2c PF12238.8 KII71605.1 - 0.049 13.6 0.1 0.061 13.3 0.1 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c YdaS_antitoxin PF15943.5 KII71605.1 - 0.05 13.5 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DUF2344 PF10105.9 KII71605.1 - 0.057 13.3 0.4 0.1 12.5 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) UNC119_bdg PF15435.6 KII71606.1 - 0.036 13.6 0.6 0.051 13.1 0.6 1.2 1 0 0 1 1 1 0 UNC119-binding protein C5orf30 homologue Secapin PF17521.2 KII71606.1 - 0.093 12.5 0.3 0.26 11.1 0.3 1.7 1 0 0 1 1 1 0 Honey bee peptides Exo70 PF03081.15 KII71608.1 - 2.2e-14 53.3 0.3 2.4e-14 53.2 0.3 1.0 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Cpn60_TCP1 PF00118.24 KII71608.1 - 0.0056 15.4 0.1 0.0056 15.4 0.1 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family p25-alpha PF05517.12 KII71609.1 - 0.059 13.5 0.9 0.12 12.5 0.8 1.8 1 1 0 1 1 1 0 p25-alpha E1_dh PF00676.20 KII71611.1 - 2.3e-87 292.8 0.1 3.8e-86 288.7 0.1 2.0 1 1 0 1 1 1 1 Dehydrogenase E1 component RRM_1 PF00076.22 KII71612.1 - 0.0035 17.1 0.0 0.0078 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phage_HK97_TLTM PF06120.11 KII71613.1 - 0.022 14.0 0.1 0.028 13.6 0.1 1.1 1 0 0 1 1 1 0 Tail length tape measure protein Rx_N PF18052.1 KII71613.1 - 0.027 14.7 1.6 0.12 12.7 1.7 2.0 2 1 0 2 2 2 0 Rx N-terminal domain Casc1_N PF15927.5 KII71613.1 - 0.099 12.3 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Tropomyosin_1 PF12718.7 KII71613.1 - 0.13 12.4 0.6 0.18 11.9 0.6 1.2 1 0 0 1 1 1 0 Tropomyosin like DASH_Spc34 PF08657.10 KII71615.1 - 0.006 16.4 0.3 0.0064 16.3 0.3 1.1 1 0 0 1 1 1 1 DASH complex subunit Spc34 Glypican PF01153.19 KII71615.1 - 0.0072 15.2 0.3 0.0081 15.0 0.3 1.0 1 0 0 1 1 1 1 Glypican TMIE PF16038.5 KII71615.1 - 0.061 13.2 0.2 0.29 11.0 0.0 2.0 1 1 1 2 2 2 0 TMIE protein FERM_N PF09379.10 KII71617.1 - 5.6e-12 45.4 3.8 8.8e-12 44.8 0.4 2.6 3 0 0 3 3 3 1 FERM N-terminal domain FERM_M PF00373.18 KII71617.1 - 1.1e-11 45.1 0.1 3e-11 43.8 0.1 1.7 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 KII71617.1 - 1.3e-08 35.1 0.0 2.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain IU_nuc_hydro PF01156.19 KII71618.1 - 3.6e-15 56.3 0.0 4e-15 56.2 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase EF-hand_7 PF13499.6 KII71620.1 - 3.9e-22 78.5 0.8 2e-14 53.8 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KII71620.1 - 4.3e-15 54.3 1.0 8.9e-06 25.2 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KII71620.1 - 7.2e-15 53.3 3.7 6e-05 22.3 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KII71620.1 - 4.5e-10 39.2 0.4 2.4e-06 27.3 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KII71620.1 - 7.6e-08 31.5 1.0 0.00019 20.8 0.1 3.7 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.9 KII71620.1 - 6.1e-05 23.3 0.1 0.14 12.5 0.0 2.5 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_13 PF17958.1 KII71620.1 - 0.00044 20.0 0.0 0.93 9.3 0.0 3.3 2 1 0 2 2 2 1 EF-hand domain EF-hand_9 PF14658.6 KII71620.1 - 0.0029 17.9 0.1 0.008 16.5 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain RST PF12174.8 KII71620.1 - 0.0032 17.4 1.5 0.019 14.9 0.1 2.6 2 2 1 3 3 3 1 RCD1-SRO-TAF4 (RST) plant domain DHOase PF12890.7 KII71620.1 - 0.0035 17.3 0.0 0.0047 16.8 0.0 1.2 1 0 0 1 1 1 1 Dihydro-orotase-like EF-hand_4 PF12763.7 KII71620.1 - 0.083 12.9 0.1 0.25 11.3 0.1 1.8 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 KII71620.1 - 0.13 12.6 0.3 4.5 7.7 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain Helicase_C PF00271.31 KII71621.1 - 1.3e-23 83.4 0.0 1.7e-23 83.1 0.0 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S4 PF01479.25 KII71622.1 - 2.9e-09 36.5 0.4 7.4e-09 35.2 0.4 1.7 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 KII71622.1 - 2e-06 28.6 2.1 9.2e-06 26.5 0.8 2.5 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain DDE_1 PF03184.19 KII71623.1 - 0.0001 22.0 0.3 0.00027 20.6 0.2 1.8 1 1 1 2 2 2 1 DDE superfamily endonuclease DUF3515 PF12028.8 KII71624.1 - 0.0011 18.8 0.3 0.39 10.4 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3515) DDE_Tnp_IS1595 PF12762.7 KII71627.1 - 0.002 18.2 0.0 0.0042 17.1 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII71630.1 - 7.5e-05 22.8 1.0 0.00011 22.3 1.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Dimer_Tnp_hAT PF05699.14 KII71631.1 - 9.1e-07 28.6 0.1 1.9e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ribosomal_S17_N PF16205.5 KII71635.1 - 7.3e-30 103.1 0.8 7.3e-30 103.1 0.8 1.9 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 KII71635.1 - 3.4e-24 84.7 3.0 3.4e-24 84.7 3.0 1.8 2 0 0 2 2 2 1 Ribosomal protein S17 AFP_2 PF18815.1 KII71635.1 - 0.084 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial antifreeze protein repeat DDE_3 PF13358.6 KII71638.1 - 6.3e-08 32.5 0.0 6.9e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII71639.1 - 6.6e-13 48.1 0.4 1e-08 34.7 0.0 2.4 2 0 0 2 2 2 2 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 KII71639.1 - 7.7e-09 34.8 1.5 4.7e-07 29.1 0.1 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 PAX PF00292.18 KII71639.1 - 4.5e-08 33.1 0.2 5.5e-08 32.8 0.2 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 KII71639.1 - 4.4e-07 30.4 0.7 0.00026 21.6 0.0 2.1 1 1 1 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.6 KII71639.1 - 1.8e-06 27.9 0.2 4.9e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 KII71639.1 - 2e-06 28.0 0.1 3.1e-06 27.4 0.1 1.4 1 1 0 1 1 1 1 Transposase HTH_38 PF13936.6 KII71639.1 - 6.7e-06 25.8 1.3 2.1e-05 24.2 0.8 2.0 2 1 0 2 2 2 1 Helix-turn-helix domain DUF1323 PF07037.11 KII71639.1 - 8.1e-06 26.2 0.3 1.5e-05 25.3 0.3 1.6 1 1 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_29 PF13551.6 KII71639.1 - 8.5e-06 25.7 0.1 0.00029 20.8 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn helix Bot1p PF12298.8 KII71639.1 - 9.9e-06 25.8 1.0 1.3e-05 25.5 1.0 1.0 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein CENP-B_N PF04218.13 KII71639.1 - 1.3e-05 24.8 0.9 5.1e-05 22.8 0.1 2.2 2 1 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_33 PF13592.6 KII71639.1 - 1.7e-05 24.4 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII71639.1 - 0.00044 20.4 0.9 0.0019 18.4 0.0 2.2 2 1 0 2 2 2 1 Transposase HTH_3 PF01381.22 KII71639.1 - 0.0014 18.6 0.0 0.023 14.8 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix HTH_24 PF13412.6 KII71639.1 - 0.0044 16.5 2.0 0.49 10.0 0.1 2.9 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_7 PF02796.15 KII71639.1 - 0.0048 16.9 1.7 0.26 11.4 0.3 2.6 2 2 0 2 2 2 1 Helix-turn-helix domain of resolvase TrmB PF01978.19 KII71639.1 - 0.0061 16.4 0.1 0.053 13.4 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MSP1a PF11670.8 KII71639.1 - 0.0085 15.4 0.0 0.014 14.7 0.0 1.3 1 1 0 1 1 1 1 Major surface protein 1a (MSP1a) HTH_Tnp_IS630 PF01710.16 KII71639.1 - 0.0089 16.1 1.5 0.034 14.2 1.5 1.8 1 1 0 1 1 1 1 Transposase TnsD PF15978.5 KII71639.1 - 0.0091 15.0 1.0 0.037 13.0 0.4 1.8 1 1 1 2 2 2 1 Tn7-like transposition protein D LacI PF00356.21 KII71639.1 - 0.013 15.3 1.2 11 5.9 0.0 3.6 3 1 1 4 4 4 0 Bacterial regulatory proteins, lacI family HTH_40 PF14493.6 KII71639.1 - 0.016 15.7 0.0 0.029 14.8 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain SpoIIID PF12116.8 KII71639.1 - 0.019 15.0 1.2 0.34 11.0 1.1 2.3 1 1 0 1 1 1 0 Stage III sporulation protein D YdaS_antitoxin PF15943.5 KII71639.1 - 0.024 14.5 0.2 9.7 6.1 0.1 2.5 3 0 0 3 3 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Tn7_Tnp_TnsA_C PF08721.11 KII71639.1 - 0.029 15.0 0.0 4.7 7.9 0.0 2.4 2 1 0 2 2 2 0 TnsA endonuclease C terminal HTH_Tnp_1_2 PF13022.6 KII71639.1 - 0.031 14.4 0.5 0.1 12.7 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase Arg_repressor PF01316.21 KII71639.1 - 0.038 13.7 1.3 0.065 13.0 0.1 1.9 2 1 0 2 2 2 0 Arginine repressor, DNA binding domain Sigma70_r4_2 PF08281.12 KII71639.1 - 0.039 13.6 0.0 0.34 10.6 0.0 2.2 2 1 0 2 2 2 0 Sigma-70, region 4 HTH_DeoR PF08220.12 KII71639.1 - 0.041 13.6 1.0 0.23 11.2 0.1 2.3 2 1 0 2 2 2 0 DeoR-like helix-turn-helix domain KORA PF16509.5 KII71639.1 - 0.043 14.1 1.2 0.059 13.7 0.3 1.6 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor Sigma70_r4 PF04545.16 KII71639.1 - 0.045 13.3 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_11 PF08279.12 KII71639.1 - 0.067 13.2 1.1 0.17 11.8 0.0 2.2 3 0 0 3 3 2 0 HTH domain HTH_37 PF13744.6 KII71639.1 - 0.091 12.7 0.3 1.8 8.6 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_17 PF12728.7 KII71639.1 - 0.12 12.5 0.0 4.7 7.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain EloA-BP1 PF15870.5 KII71640.1 - 0.012 15.9 0.4 0.016 15.5 0.4 1.4 1 0 0 1 1 1 0 ElonginA binding-protein 1 DDE_3 PF13358.6 KII71640.1 - 0.14 11.9 0.1 0.38 10.5 0.1 1.8 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_32 PF13565.6 KII71644.1 - 5e-08 33.4 0.0 6.3e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_23 PF13384.6 KII71644.1 - 0.007 16.1 0.0 0.3 11.0 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 KII71644.1 - 0.0086 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix Rep_3 PF01051.21 KII71644.1 - 0.0098 15.7 0.1 0.011 15.6 0.1 1.1 1 0 0 1 1 1 1 Initiator Replication protein HTH_Tnp_Tc3_2 PF01498.18 KII71644.1 - 0.014 15.6 0.3 0.081 13.2 0.0 2.2 2 1 0 2 2 2 0 Transposase MRG PF05712.13 KII71644.1 - 0.032 13.5 0.1 0.037 13.3 0.1 1.1 1 0 0 1 1 1 0 MRG DUF4817 PF16087.5 KII71644.1 - 0.036 13.9 0.3 0.12 12.2 0.1 2.0 3 0 0 3 3 3 0 Helix-turn-helix domain (DUF4817) HTH_29 PF13551.6 KII71644.1 - 0.061 13.3 0.2 0.77 9.8 0.1 2.4 2 1 0 2 2 2 0 Winged helix-turn helix Ntox50 PF15542.6 KII71644.1 - 0.076 13.8 3.4 3.8 8.4 3.4 2.3 1 1 0 1 1 1 0 Bacterial toxin 50 RT_RNaseH_2 PF17919.1 KII71645.1 - 0.01 15.9 0.0 0.014 15.4 0.0 1.1 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase P_proprotein PF01483.20 KII71647.1 - 1.3e-21 76.4 0.0 1.9e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Ank_2 PF12796.7 KII71648.1 - 0.00091 19.8 7.9 0.012 16.2 1.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PDZ_6 PF17820.1 KII71648.1 - 0.0011 18.8 0.0 0.0036 17.1 0.0 1.9 1 0 0 1 1 1 1 PDZ domain Ank_4 PF13637.6 KII71648.1 - 0.0065 17.0 0.2 0.079 13.6 0.1 2.7 1 1 2 3 3 3 1 Ankyrin repeats (many copies) PDZ PF00595.24 KII71648.1 - 0.013 15.8 0.0 0.034 14.5 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Ank_3 PF13606.6 KII71648.1 - 0.26 12.0 3.5 34 5.5 0.1 3.5 3 0 0 3 3 3 0 Ankyrin repeat Ldl_recept_a PF00057.18 KII71650.1 - 3.6e-05 23.9 7.9 7.8e-05 22.8 7.9 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A IL17R_fnIII_D1 PF16556.5 KII71650.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Interleukin-17 receptor, fibronectin-III-like domain 1 ComR_TPR PF18710.1 KII71652.1 - 0.029 13.9 5.5 0.59 9.6 2.0 2.0 1 1 1 2 2 2 0 ComR tetratricopeptide Sortilin-Vps10 PF15902.5 KII71654.1 - 5e-07 28.9 1.1 1.3e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII71654.1 - 0.0031 17.3 0.8 0.94 9.7 0.1 3.0 2 0 0 2 2 2 2 BNR/Asp-box repeat DUF3726 PF12525.8 KII71654.1 - 0.14 12.3 0.0 0.7 10.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3726) Ldl_recept_a PF00057.18 KII71655.1 - 2.1e-09 37.4 24.0 0.00014 22.0 9.9 2.5 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A CgtA PF06306.11 KII71655.1 - 0.0044 16.5 2.9 0.33 10.3 0.2 2.1 1 1 1 2 2 2 2 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA) PRKCSH-like PF12999.7 KII71655.1 - 0.059 13.2 15.2 0.075 12.8 15.2 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like NOPS PF08075.11 KII71655.1 - 0.072 13.3 0.1 0.83 9.9 0.0 2.1 2 0 0 2 2 2 0 NOPS (NUC059) domain Ldl_recept_a PF00057.18 KII71658.1 - 0.0026 18.0 9.6 0.0026 18.0 9.6 2.4 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII71660.1 - 2.7e-16 59.5 34.1 6.4e-09 35.9 14.4 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PyrI_C PF02748.15 KII71660.1 - 0.14 12.1 8.1 1.5 8.8 1.6 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Crisp PF08562.10 KII71660.1 - 6.8 7.4 21.4 2.1 9.0 4.2 2.5 1 1 1 2 2 2 0 Crisp DUF1719 PF08224.11 KII71662.1 - 0.1 11.7 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1719) DUF5093 PF17011.5 KII71663.1 - 0.17 12.1 4.3 0.19 12.0 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) DUF4371 PF14291.6 KII71664.1 - 9.6e-05 22.1 0.1 0.00012 21.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Lipoprotein_11 PF03260.13 KII71665.1 - 0.024 14.0 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 Lepidopteran low molecular weight (30 kD) lipoprotein MTS PF05175.14 KII71667.1 - 0.023 14.3 0.5 4.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase small domain tRNA-synt_1e PF01406.19 KII71667.1 - 0.039 13.3 0.1 8.7 5.6 0.0 2.2 2 1 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Oxidored_q2 PF00420.24 KII71667.1 - 0.074 12.7 1.3 9.5 5.9 0.0 2.3 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DNA_photolyase PF00875.18 KII71670.1 - 1.6e-17 64.0 0.0 3.2e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase GRAS PF03514.14 KII71670.1 - 0.1 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 GRAS domain family zf-C2H2 PF00096.26 KII71671.1 - 3e-10 40.0 8.1 4.9e-05 23.5 0.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII71671.1 - 2e-09 37.5 7.6 0.00053 20.6 1.0 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 KII71671.1 - 8.5e-06 26.0 5.0 0.003 17.9 1.3 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KII71671.1 - 9.4e-06 25.8 4.7 0.018 15.3 0.3 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KII71671.1 - 4.3e-05 23.8 3.7 0.045 14.1 0.2 2.3 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 KII71671.1 - 4.8e-05 23.0 6.7 0.0054 16.5 1.0 2.4 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 KII71671.1 - 0.00052 20.3 10.9 2 9.0 0.0 4.4 4 1 0 4 4 4 2 Zinc-finger double domain zf-C2HC_2 PF13913.6 KII71671.1 - 0.00091 19.1 3.0 0.00091 19.1 3.0 2.9 3 0 0 3 3 3 1 zinc-finger of a C2HC-type zf-C2H2_3rep PF18868.1 KII71671.1 - 0.00094 19.9 1.2 0.004 17.8 1.0 2.1 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 KII71671.1 - 0.0018 18.2 5.4 0.0025 17.8 0.5 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-Di19 PF05605.12 KII71671.1 - 0.027 14.8 2.1 0.71 10.2 0.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 KII71671.1 - 0.06 13.4 0.7 4.2 7.5 0.1 2.4 2 0 0 2 2 2 0 BED zinc finger DUF629 PF04780.12 KII71671.1 - 0.33 9.4 2.9 0.42 9.1 0.3 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF629) LIM PF00412.22 KII71671.1 - 0.37 11.1 5.3 1.2 9.4 0.4 2.4 1 1 1 2 2 2 0 LIM domain Actin_micro PF17003.5 KII71671.1 - 0.66 9.1 6.5 14 4.8 3.9 2.5 2 1 0 2 2 2 0 Putative actin-like family Zf_RING PF16744.5 KII71671.1 - 1.5 9.0 5.0 3 8.0 1.7 2.4 1 1 1 2 2 2 0 KIAA1045 RING finger Sortilin_C PF15901.5 KII71672.1 - 7.7e-09 36.1 0.2 1e-08 35.7 0.2 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal SR1P PF13790.6 KII71672.1 - 0.1 12.7 0.4 7.3 6.8 0.1 2.5 2 0 0 2 2 2 0 SR1 protein Ldl_recept_a PF00057.18 KII71673.1 - 2.9e-05 24.2 16.1 2.9e-05 24.2 16.1 2.6 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A DDE_3 PF13358.6 KII71674.1 - 3.2e-16 59.4 0.0 4.4e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII71674.1 - 0.0019 17.9 0.0 0.0027 17.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Sortilin-Vps10 PF15902.5 KII71675.1 - 1.9e-09 36.9 0.0 2.3e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII71675.1 - 0.00012 21.6 1.1 0.34 11.1 0.0 3.1 3 0 0 3 3 3 2 BNR/Asp-box repeat AXE1 PF05448.12 KII71675.1 - 0.0086 14.8 0.2 0.012 14.3 0.2 1.2 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Campylo_MOMP PF05538.11 KII71678.1 - 0.016 14.3 0.2 0.019 14.0 0.2 1.1 1 0 0 1 1 1 0 Campylobacter major outer membrane protein PTH2 PF01981.16 KII71679.1 - 5.1e-20 71.9 0.0 5.7e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Sina PF03145.16 KII71680.1 - 3.1e-17 63.2 0.2 3.1e-17 63.2 0.2 1.8 1 1 1 2 2 2 1 Seven in absentia protein family zf-C3HC4_2 PF13923.6 KII71680.1 - 0.064 13.1 14.8 0.15 11.9 14.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KII71680.1 - 2.1 8.4 15.8 0.64 10.1 10.8 2.6 2 1 1 3 3 3 0 RING-type zinc-finger zf-CCHC PF00098.23 KII71681.1 - 2.6e-05 24.1 1.4 4.2e-05 23.4 1.4 1.3 1 0 0 1 1 1 1 Zinc knuckle GcrA PF07750.11 KII71681.1 - 0.076 13.4 0.0 0.15 12.4 0.0 1.4 1 1 0 1 1 1 0 GcrA cell cycle regulator RVT_1 PF00078.27 KII71683.1 - 8.2e-18 64.7 0.2 1.1e-17 64.3 0.2 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII71689.1 - 5.4e-12 45.9 0.1 8.6e-12 45.3 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71689.1 - 0.00031 20.7 0.1 0.00051 20.0 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF3834 PF12916.7 KII71690.1 - 0.081 12.2 0.0 0.096 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) HTH_Tnp_Tc3_2 PF01498.18 KII71690.1 - 0.14 12.5 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Transposase SNAP PF14938.6 KII71691.1 - 2.1e-06 27.4 0.0 2.8e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP BCNT PF07572.12 KII71691.1 - 0.09 12.9 0.4 14 5.9 0.1 2.6 3 0 0 3 3 3 0 Bucentaur or craniofacial development GGDEF_2 PF17853.1 KII71691.1 - 0.16 12.2 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 GGDEF-like domain SNAP PF14938.6 KII71692.1 - 1.5e-06 27.8 0.0 2.1e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP BCNT PF07572.12 KII71692.1 - 0.11 12.5 0.5 14 5.8 0.1 2.5 3 0 0 3 3 3 0 Bucentaur or craniofacial development DivIC PF04977.15 KII71694.1 - 0.0061 16.3 8.2 0.12 12.1 2.8 2.2 2 0 0 2 2 2 2 Septum formation initiator DUF1664 PF07889.12 KII71694.1 - 0.0062 16.6 5.2 0.39 10.7 0.3 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 KII71694.1 - 0.011 15.7 10.9 0.11 12.5 3.1 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 KII71694.1 - 0.013 16.0 5.5 0.013 16.0 5.5 1.9 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF349 PF03993.12 KII71694.1 - 0.019 15.2 1.9 0.039 14.2 1.9 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) STAT_alpha PF01017.20 KII71694.1 - 0.04 13.8 9.3 0.06 13.2 9.3 1.3 1 0 0 1 1 1 0 STAT protein, all-alpha domain JIP_LZII PF16471.5 KII71694.1 - 0.053 13.7 2.4 0.053 13.7 2.4 2.3 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Prefoldin_2 PF01920.20 KII71694.1 - 0.057 13.4 11.2 0.11 12.5 4.3 2.3 2 0 0 2 2 2 0 Prefoldin subunit Thermopsin PF05317.11 KII71694.1 - 0.057 12.9 0.1 0.07 12.6 0.1 1.1 1 0 0 1 1 1 0 Thermopsin Lysozyme_like PF13702.6 KII71694.1 - 0.067 12.9 1.8 0.7 9.6 0.1 2.1 1 1 1 2 2 2 0 Lysozyme-like Prefoldin PF02996.17 KII71694.1 - 0.075 12.9 8.6 0.094 12.6 3.2 2.2 2 0 0 2 2 2 0 Prefoldin subunit HALZ PF02183.18 KII71694.1 - 0.077 13.2 6.8 7.6 6.8 3.9 2.6 2 1 0 2 2 2 0 Homeobox associated leucine zipper CENP-F_leu_zip PF10473.9 KII71694.1 - 0.096 12.7 13.1 0.069 13.2 6.8 2.1 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1465 PF07323.12 KII71694.1 - 0.11 12.3 5.4 0.87 9.4 2.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) Spc24 PF08286.11 KII71694.1 - 0.22 11.8 10.2 0.27 11.5 3.7 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4140 PF13600.6 KII71694.1 - 0.46 10.9 2.9 1.1 9.7 0.4 2.0 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) YabA PF06156.13 KII71694.1 - 0.47 11.1 9.2 4.6 7.9 2.0 2.2 1 1 1 2 2 2 0 Initiation control protein YabA FlxA PF14282.6 KII71694.1 - 0.47 10.5 11.5 1 9.4 3.5 2.3 2 0 0 2 2 2 0 FlxA-like protein UPF0449 PF15136.6 KII71694.1 - 1 9.8 7.5 0.4 11.2 3.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 GIT_CC PF16559.5 KII71694.1 - 2.3 8.2 11.7 0.93 9.4 3.4 2.4 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor FapA PF03961.13 KII71694.1 - 2.7 6.5 10.8 6.1 5.3 10.8 1.6 1 1 0 1 1 1 0 Flagellar Assembly Protein A Cortex-I_coil PF09304.10 KII71694.1 - 2.8 8.2 10.7 2 8.7 4.5 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil DUF3450 PF11932.8 KII71694.1 - 5.6 6.2 10.1 2.8 7.2 3.7 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) DUF5320 PF17253.2 KII71694.1 - 6.1 8.0 5.0 1.8 9.7 0.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5320) TPR_8 PF13181.6 KII71696.1 - 0.024 14.8 3.7 0.4 11.0 0.3 3.2 3 1 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 KII71696.1 - 1.1 10.4 7.0 1.8 9.7 1.3 3.1 2 0 0 2 2 2 0 Aromatic-di-Alanine (AdAR) repeat NolX PF05819.11 KII71697.1 - 0.25 10.6 0.1 0.32 10.3 0.1 1.1 1 0 0 1 1 1 0 NolX protein TMEM43 PF07787.12 KII71697.1 - 4.9 6.5 8.5 7.2 5.9 8.5 1.4 1 1 0 1 1 1 0 Transmembrane protein 43 CMV_1a_C PF12503.8 KII71700.1 - 1.4e-07 31.4 9.0 65 3.6 0.0 8.3 8 0 0 8 8 8 0 Cucumber mosaic virus 1a protein C terminal Ntox5 PF15543.6 KII71700.1 - 0.00012 21.9 0.0 2.8e+02 1.3 0.0 6.6 7 0 0 7 7 7 0 Bacterial toxin 5 DUF2415 PF10313.9 KII71700.1 - 0.00013 21.8 0.0 4.3e+02 1.0 0.0 7.3 8 0 0 8 8 8 0 Uncharacterised protein domain (DUF2415) Synapsin_N PF10581.9 KII71700.1 - 0.19 11.7 12.4 2.6e+02 1.7 0.0 6.9 7 0 0 7 7 7 0 Synapsin N-terminal KdgM PF06178.13 KII71700.1 - 1.3 8.6 12.9 3e+02 0.9 4.1 7.6 8 0 0 8 8 8 0 Oligogalacturonate-specific porin protein (KdgM) DegS PF05384.11 KII71701.1 - 6.9e-05 22.4 6.0 0.0018 17.8 1.5 2.1 2 0 0 2 2 2 2 Sensor protein DegS Uds1 PF15456.6 KII71701.1 - 0.00092 19.4 5.8 0.0016 18.6 5.6 1.5 1 1 0 1 1 1 1 Up-regulated During Septation RPW8 PF05659.11 KII71701.1 - 0.011 15.4 7.9 0.015 15.0 0.8 2.1 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Mer2 PF09074.10 KII71701.1 - 0.014 15.2 12.1 0.36 10.6 12.1 2.1 1 1 0 1 1 1 0 Mer2 rRNA_proc-arch PF13234.6 KII71701.1 - 0.015 15.3 4.5 0.027 14.4 0.6 2.1 1 1 1 2 2 2 0 rRNA-processing arch domain CDC24 PF06395.11 KII71701.1 - 0.038 14.2 0.1 0.073 13.3 0.1 1.4 1 0 0 1 1 1 0 CDC24 Calponin DUF848 PF05852.11 KII71701.1 - 0.077 13.1 6.8 0.34 11.0 0.9 2.1 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Lipoprotein_7 PF01540.16 KII71701.1 - 0.08 12.2 8.7 0.2 10.9 0.7 2.0 2 0 0 2 2 2 0 Adhesin lipoprotein RE_AlwI PF09491.10 KII71701.1 - 0.13 11.0 9.1 0.15 10.8 9.1 1.1 1 0 0 1 1 1 0 AlwI restriction endonuclease UPF0242 PF06785.11 KII71701.1 - 0.2 11.7 9.0 0.28 11.3 9.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus COG2 PF06148.11 KII71701.1 - 0.22 11.6 4.7 0.61 10.2 0.7 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 LMBR1 PF04791.16 KII71701.1 - 0.23 10.3 7.0 0.26 10.2 7.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4795 PF16043.5 KII71701.1 - 0.28 10.8 9.5 0.78 9.3 3.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Spc7 PF08317.11 KII71701.1 - 0.29 10.0 12.0 0.87 8.4 11.8 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein DASH_Dam1 PF08653.10 KII71701.1 - 0.3 10.9 4.8 0.82 9.5 0.4 2.9 2 1 1 3 3 3 0 DASH complex subunit Dam1 DUF948 PF06103.11 KII71701.1 - 0.46 10.8 7.7 0.13 12.6 2.3 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 KII71701.1 - 0.52 10.4 8.5 3.5 7.7 1.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 KII71701.1 - 0.53 10.8 6.1 1.1 9.8 1.4 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.6 KII71701.1 - 0.7 10.4 3.9 9.3 6.8 3.9 2.4 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) TMF_DNA_bd PF12329.8 KII71701.1 - 3.2 7.8 15.6 1.6 8.8 5.1 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding NuA4 PF09340.10 KII71701.1 - 3.3 7.7 9.5 6.1 6.8 3.5 3.1 1 1 1 2 2 2 0 Histone acetyltransferase subunit NuA4 DUF16 PF01519.16 KII71701.1 - 5.6 7.5 13.1 4.7e+02 1.3 13.1 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 gag-asp_proteas PF13975.6 KII71702.1 - 0.009 16.5 0.0 0.019 15.5 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Phage_pRha PF09669.10 KII71703.1 - 0.01 16.4 0.4 0.015 15.8 0.4 1.5 1 1 0 1 1 1 1 Phage regulatory protein Rha (Phage_pRha) Cytochrom_B562 PF07361.11 KII71703.1 - 0.049 14.3 0.0 0.069 13.8 0.0 1.2 1 0 0 1 1 1 0 Cytochrome b562 HGTP_anticodon PF03129.20 KII71703.1 - 0.091 12.9 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Anticodon binding domain NQRA_SLBB PF11973.8 KII71703.1 - 0.15 12.7 0.0 13 6.5 0.0 2.6 3 0 0 3 3 3 0 NQRA C-terminal domain Laminin_II PF06009.12 KII71705.1 - 0.0092 16.0 0.5 0.26 11.3 0.1 2.1 2 0 0 2 2 2 1 Laminin Domain II DUF4763 PF15960.5 KII71705.1 - 0.02 14.2 0.2 0.02 14.2 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) TACC_C PF05010.14 KII71705.1 - 0.041 13.7 5.5 0.067 13.0 0.8 2.0 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1664 PF07889.12 KII71706.1 - 0.055 13.5 2.3 0.21 11.6 2.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 KII71706.1 - 0.72 10.3 8.7 0.52 10.7 2.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) XhlA PF10779.9 KII71706.1 - 3.4 7.9 9.8 0.72 10.1 2.4 2.7 2 1 0 2 2 2 0 Haemolysin XhlA E3_UFM1_ligase PF09743.9 KII71707.1 - 2.7e-55 187.9 0.1 2.7e-55 187.9 0.1 2.9 2 1 1 3 3 3 1 E3 UFM1-protein ligase 1 HAUS2 PF15003.6 KII71707.1 - 0.037 13.8 2.3 0.042 13.6 0.6 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 TipE PF16972.5 KII71709.1 - 0.17 11.1 1.0 0.19 10.8 1.0 1.0 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE DUF3724 PF12521.8 KII71709.1 - 0.4 10.7 3.2 0.77 9.8 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3724) Metallophos PF00149.28 KII71710.1 - 1.3e-08 35.7 3.9 1.6e-08 35.3 3.9 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TetM_leader PF08076.11 KII71710.1 - 0.14 12.0 0.1 0.36 10.7 0.1 1.7 1 0 0 1 1 1 0 Tetracycline resistance determinant leader peptide Baculo_RING PF05883.11 KII71711.1 - 0.019 14.9 0.0 0.036 14.1 0.0 1.4 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain MTS PF05175.14 KII71712.1 - 1.4e-13 50.7 0.0 2e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 KII71712.1 - 5e-09 36.0 0.0 8.3e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KII71712.1 - 3.9e-08 33.9 0.0 7.7e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KII71712.1 - 1.3e-07 31.6 0.1 1.8e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII71712.1 - 4.8e-05 23.9 0.0 9.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KII71712.1 - 7.9e-05 22.4 0.0 0.0001 22.0 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 KII71712.1 - 0.00057 19.6 0.2 0.0059 16.3 0.2 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 KII71712.1 - 0.0083 15.4 0.0 0.019 14.2 0.0 1.6 1 1 0 1 1 1 1 N-6 DNA Methylase Methyltransf_12 PF08242.12 KII71712.1 - 0.073 13.8 0.0 0.14 12.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 KII71712.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 KII71712.1 - 0.17 11.8 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain HTH_32 PF13565.6 KII71713.1 - 4e-05 24.2 0.0 0.073 13.7 0.0 2.2 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 KII71713.1 - 0.006 16.3 0.0 0.037 13.8 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain CENP-B_N PF04218.13 KII71713.1 - 0.048 13.3 0.2 0.087 12.5 0.2 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Gp-FAR-1 PF05823.12 KII71713.1 - 0.063 13.6 0.2 0.12 12.7 0.2 1.4 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) ApoLp-III PF07464.11 KII71713.1 - 0.078 13.1 0.0 0.097 12.8 0.0 1.2 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) TrmB PF01978.19 KII71713.1 - 0.082 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF1323 PF07037.11 KII71713.1 - 0.095 13.1 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) HTH_17 PF12728.7 KII71713.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain RVT_1 PF00078.27 KII71716.1 - 0.005 16.4 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2806 PF10987.8 KII71717.1 - 0.044 13.7 0.1 0.051 13.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2806) WH1 PF00568.23 KII71719.1 - 2.3e-07 30.7 0.3 3.6e-07 30.1 0.2 1.4 1 1 0 1 1 1 1 WH1 domain Ldl_recept_a PF00057.18 KII71722.1 - 1.7e-10 40.9 26.0 2.7e-06 27.5 8.4 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A C1q PF00386.21 KII71725.1 - 0.0097 16.1 0.4 1.5 9.0 0.1 2.3 1 1 1 2 2 2 2 C1q domain Kelch_3 PF13415.6 KII71725.1 - 0.025 14.9 0.1 1.4 9.3 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain ThiF PF00899.21 KII71726.1 - 2.2e-21 76.4 0.1 3.3e-21 75.8 0.1 1.3 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 KII71726.1 - 0.12 12.5 0.1 0.16 12.0 0.1 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 KII71726.1 - 0.13 12.6 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain RRM_1 PF00076.22 KII71727.1 - 9.7e-36 121.4 0.0 7.7e-18 64.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KII71727.1 - 4.6e-05 23.0 0.0 0.048 13.3 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII71727.1 - 0.00063 19.8 0.1 0.03 14.4 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif Cas_Cas2CT1978 PF09707.10 KII71727.1 - 0.064 13.3 0.0 14 5.8 0.0 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) V-set_CD47 PF08204.11 KII71728.1 - 0.17 11.9 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain RT_RNaseH PF17917.1 KII71730.1 - 7.4e-37 125.8 0.1 2.4e-36 124.2 0.1 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71730.1 - 5.7e-35 119.4 0.2 2.5e-34 117.3 0.0 2.3 3 0 0 3 3 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71730.1 - 7.9e-27 94.2 0.1 2e-26 92.9 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII71730.1 - 5.9e-25 87.8 0.0 2.3e-24 85.9 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71730.1 - 2.3e-17 62.8 0.2 1e-16 60.8 0.2 2.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 KII71730.1 - 6.3e-06 26.0 11.2 0.0024 17.9 2.0 2.7 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII71730.1 - 3.8e-05 23.9 0.0 0.00019 21.7 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII71730.1 - 0.00035 21.2 0.0 0.00086 19.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII71730.1 - 0.00044 20.7 0.0 0.001 19.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII71730.1 - 0.0014 18.4 0.1 0.0037 17.1 0.1 1.7 1 1 0 1 1 1 1 Aspartyl protease rve_3 PF13683.6 KII71730.1 - 0.0033 17.1 0.0 0.011 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.11 KII71730.1 - 0.0056 16.5 0.3 0.012 15.4 0.3 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.6 KII71730.1 - 0.0097 15.9 5.9 0.025 14.6 0.5 2.5 1 1 1 2 2 2 1 Zinc knuckle zf-H2C2 PF09337.10 KII71730.1 - 0.086 13.1 0.8 0.36 11.1 0.1 2.5 2 0 0 2 2 2 0 H2C2 zinc finger Herpes_UL14 PF03580.14 KII71730.1 - 0.092 13.0 0.8 0.17 12.1 0.0 1.8 2 0 0 2 2 1 0 Herpesvirus UL14-like protein Peptidase_A2B PF12384.8 KII71730.1 - 0.12 11.9 0.0 0.61 9.6 0.0 2.0 1 1 0 2 2 2 0 Ty3 transposon peptidase Zn_Tnp_IS91 PF14319.6 KII71730.1 - 0.56 10.3 7.9 0.38 10.8 3.7 2.9 2 0 0 2 2 2 0 Transposase zinc-binding domain PHD_4 PF16866.5 KII71730.1 - 8.1 6.6 7.3 1.3 9.2 1.3 2.8 3 1 1 4 4 4 0 PHD-finger DDE_3 PF13358.6 KII71731.1 - 1.6e-11 44.2 0.0 2e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Galactosyl_T PF01762.21 KII71732.1 - 7.2e-31 107.5 0.9 9.9e-31 107.1 0.9 1.2 1 0 0 1 1 1 1 Galactosyltransferase Clat_adaptor_s PF01217.20 KII71733.1 - 1.9e-24 86.2 4.6 2.2e-24 86.0 4.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain MRG PF05712.13 KII71733.1 - 0.05 12.9 0.2 0.05 12.9 0.2 1.1 1 0 0 1 1 1 0 MRG COG6 PF06419.11 KII71734.1 - 9.9e-10 37.3 13.2 1.4e-09 36.8 13.2 1.1 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 DASH_Dad3 PF08656.10 KII71734.1 - 0.019 15.1 2.8 0.35 11.0 0.2 3.2 3 1 0 3 3 3 0 DASH complex subunit Dad3 SF-assemblin PF06705.11 KII71734.1 - 1.5 8.1 12.3 0.24 10.7 5.5 2.6 1 1 2 3 3 3 0 SF-assemblin/beta giardin zf-H2C2_5 PF13909.6 KII71736.1 - 6.5e-09 35.4 11.3 4.7e-06 26.2 0.0 3.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KII71736.1 - 5.4e-07 29.7 14.7 0.028 14.9 0.4 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII71736.1 - 3.3e-06 27.5 13.5 0.25 12.3 2.5 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KII71736.1 - 1.6e-05 25.1 13.7 0.0011 19.4 0.7 3.6 3 0 0 3 3 3 2 Zinc-finger double domain Auts2 PF15336.6 KII71739.1 - 0.098 12.8 6.5 0.2 11.8 4.2 2.2 2 0 0 2 2 2 0 Autism susceptibility gene 2 protein Rad9_Rad53_bind PF08605.10 KII71741.1 - 0.055 13.7 0.0 0.12 12.6 0.0 1.5 1 1 0 1 1 1 0 Fungal Rad9-like Rad53-binding Scramblase PF03803.15 KII71742.1 - 0.15 11.3 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Scramblase MRP-L47 PF06984.13 KII71743.1 - 3.6e-09 36.6 0.2 4.4e-09 36.3 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) rve PF00665.26 KII71744.1 - 1.5e-23 83.2 0.1 3e-22 79.0 0.0 2.5 2 1 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII71744.1 - 2.5e-05 24.0 0.2 0.00021 21.0 0.0 2.6 3 0 0 3 3 2 1 Integrase core domain MLVIN_C PF18697.1 KII71744.1 - 0.00016 21.7 0.0 0.00049 20.1 0.0 1.9 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Asp_protease PF09668.10 KII71744.1 - 0.0014 18.4 0.0 0.0029 17.4 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII71744.1 - 0.0015 18.8 0.0 0.0035 17.6 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII71744.1 - 0.0024 18.5 0.0 0.0099 16.5 0.0 2.1 3 0 0 3 3 2 1 Aspartyl protease gag-asp_proteas PF13975.6 KII71744.1 - 0.0087 16.6 0.0 0.026 15.1 0.0 1.9 2 0 0 2 2 1 1 gag-polyprotein putative aspartyl protease TetR_C_15 PF17918.1 KII71744.1 - 0.014 16.1 0.0 1.7 9.4 0.1 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain RVP_2 PF08284.11 KII71744.1 - 0.054 13.3 0.3 0.12 12.2 0.3 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease DUF4070 PF13282.6 KII71744.1 - 0.064 13.4 0.0 0.67 10.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4070) UN_NPL4 PF11543.8 KII71744.1 - 0.29 11.6 1.1 0.8 10.2 0.0 2.3 3 0 0 3 3 2 0 Nuclear pore localisation protein NPL4 zf-CCHC_3 PF13917.6 KII71744.1 - 0.38 10.8 9.7 2.6 8.1 1.3 2.6 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII71744.1 - 6 6.7 7.2 18 5.2 1.1 2.7 2 0 0 2 2 2 0 Zinc knuckle Syntaxin PF00804.25 KII71745.1 - 1.6e-05 24.7 5.8 0.00031 20.5 0.6 2.1 2 0 0 2 2 2 2 Syntaxin ATF7IP_BD PF16788.5 KII71745.1 - 0.023 14.8 4.0 0.033 14.3 4.0 1.4 1 1 0 1 1 1 0 ATF-interacting protein binding domain Vac_Fusion PF02346.16 KII71745.1 - 0.16 11.6 1.7 18 5.1 0.3 2.8 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DUF2477 PF10631.9 KII71746.1 - 0.0066 17.1 0.1 0.0094 16.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2477) VWA PF00092.28 KII71747.1 - 1.5e-10 41.6 0.0 1.7e-10 41.4 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KII71747.1 - 1.6e-05 25.5 0.0 1.7e-05 25.4 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain MAM33 PF02330.16 KII71748.1 - 6.9e-05 22.9 1.0 0.026 14.5 0.5 2.3 2 0 0 2 2 2 2 Mitochondrial glycoprotein E1_DerP2_DerF2 PF02221.15 KII71751.1 - 3.3e-13 50.2 0.2 4e-13 50.0 0.2 1.1 1 0 0 1 1 1 1 ML domain ATP12 PF07542.11 KII71752.1 - 9.4e-30 103.3 0.1 1.2e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 ATP12 chaperone protein DUF2405 PF10293.9 KII71752.1 - 0.02 14.9 1.0 2.9 7.8 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2405) zf-C2H2_4 PF13894.6 KII71761.1 - 0.001 19.7 13.6 0.38 11.7 3.4 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KII71761.1 - 0.0088 15.8 0.0 0.0088 15.8 0.0 2.3 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KII71761.1 - 0.014 15.9 16.2 0.16 12.5 4.0 3.7 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-TRAF PF02176.18 KII71761.1 - 1.7 9.4 13.7 1.4 9.7 3.1 2.5 2 1 1 3 3 3 0 TRAF-type zinc finger zf-H2C2_5 PF13909.6 KII71762.1 - 0.00038 20.2 2.9 0.0014 18.4 0.0 3.0 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 KII71762.1 - 0.0021 18.4 2.2 0.0021 18.4 2.2 3.6 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 KII71762.1 - 0.11 13.0 1.4 0.11 13.0 1.4 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII71762.1 - 0.13 13.2 1.0 0.13 13.2 1.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger UPF0093 PF03653.13 KII71763.1 - 0.0047 17.2 0.2 0.0058 16.9 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0093) CarD_CdnL_TRCF PF02559.16 KII71764.1 - 0.028 15.1 0.4 0.18 12.5 0.4 2.1 1 1 0 1 1 1 0 CarD-like/TRCF domain PEN-2 PF10251.9 KII71764.1 - 0.062 13.7 0.3 0.22 12.0 0.3 1.9 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase UN_NPL4 PF11543.8 KII71766.1 - 0.55 10.8 2.6 3 8.4 0.3 2.8 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 Peptidase_S66 PF02016.15 KII71767.1 - 0.12 12.5 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain Sortilin-Vps10 PF15902.5 KII71768.1 - 3.9e-07 29.2 2.3 2.9e-06 26.3 2.2 2.3 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII71768.1 - 1.2e-05 24.6 7.7 1.5 9.1 0.1 3.7 3 0 0 3 3 3 3 BNR/Asp-box repeat MFS_1 PF07690.16 KII71769.1 - 8.2e-11 41.4 8.4 8.9e-11 41.3 8.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KII71769.1 - 5.8e-06 25.4 4.1 5.9e-06 25.4 4.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter EI24 PF07264.11 KII71769.1 - 0.033 14.4 10.3 0.036 14.3 10.3 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) ATG22 PF11700.8 KII71769.1 - 0.064 11.9 4.5 0.069 11.8 4.5 1.0 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like DDE_Tnp_IS1595 PF12762.7 KII71771.1 - 7.8e-05 22.7 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain zf-TFIIB PF13453.6 KII71771.1 - 0.012 14.9 1.1 0.025 13.9 1.1 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger Ribosomal_S8e PF01201.22 KII71772.1 - 0.0002 21.5 14.4 0.00036 20.7 13.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S8e Cwf_Cwc_15 PF04889.12 KII71773.1 - 1.6e-59 201.6 20.2 2.6e-42 145.2 11.6 2.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein Phage_Gp23 PF10669.9 KII71773.1 - 5.5 7.4 11.5 0.17 12.3 4.1 2.0 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) FUSC PF04632.12 KII71773.1 - 5.8 5.3 5.2 7 5.1 5.2 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4040 PF13244.6 KII71774.1 - 0.016 15.4 0.4 0.031 14.4 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) FUSC-like PF12805.7 KII71775.1 - 0.0039 16.3 1.2 0.0039 16.3 1.2 1.8 2 0 0 2 2 2 1 FUSC-like inner membrane protein yccS DUF4396 PF14342.6 KII71775.1 - 0.32 11.3 5.6 0.46 10.8 5.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4396) B12D PF06522.11 KII71775.1 - 2.3 8.0 7.2 0.23 11.3 1.7 2.0 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF4064 PF13273.6 KII71775.1 - 2.4 8.5 12.4 0.12 12.7 4.1 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF4064) zf-C2H2_12 PF18658.1 KII71778.1 - 0.0027 17.2 0.0 0.0044 16.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger C2H2-type zf-BED PF02892.15 KII71778.1 - 0.063 13.3 0.3 0.096 12.7 0.3 1.3 1 0 0 1 1 1 0 BED zinc finger zf-met2 PF12907.7 KII71778.1 - 0.13 12.4 0.1 0.3 11.3 0.1 1.6 1 0 0 1 1 1 0 Zinc-binding SNAP PF14938.6 KII71779.1 - 0.0037 16.7 0.1 0.0042 16.5 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP HTH_38 PF13936.6 KII71782.1 - 0.00051 19.8 0.2 0.1 12.4 0.1 2.5 2 0 0 2 2 2 2 Helix-turn-helix domain CENP-B_N PF04218.13 KII71782.1 - 0.00096 18.7 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_3 PF01381.22 KII71782.1 - 0.0013 18.8 0.2 0.0037 17.3 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix LacI PF00356.21 KII71782.1 - 0.0028 17.4 0.0 0.0053 16.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_IclR PF09339.10 KII71782.1 - 0.023 14.5 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_psq PF05225.16 KII71782.1 - 0.055 13.2 0.1 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 helix-turn-helix, Psq domain TrmB PF01978.19 KII71782.1 - 0.12 12.3 0.1 0.34 10.8 0.1 1.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 KII71782.1 - 0.13 12.1 0.0 0.4 10.5 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain MetOD1 PF18546.1 KII71783.1 - 0.037 14.0 1.4 0.15 12.0 1.4 1.8 1 1 0 1 1 1 0 Metanogen output domain 1 DrrA_P4M PF14860.6 KII71783.1 - 0.1 12.5 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain Glyco_hydro_2_C PF02836.17 KII71784.1 - 0.062 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain RVT_1 PF00078.27 KII71785.1 - 0.055 13.0 0.0 0.17 11.4 0.0 1.9 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII71786.1 - 9.1e-19 67.3 1.6 9.1e-19 67.3 1.6 1.5 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII71786.1 - 0.078 13.2 0.9 0.38 11.0 0.9 2.3 1 1 0 1 1 1 0 H2C2 zinc finger AAA PF00004.29 KII71789.1 - 1.7e-22 80.3 1.0 4.3e-21 75.7 0.5 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII71789.1 - 1e-06 29.2 0.3 0.0013 19.2 0.1 2.6 1 1 1 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 KII71789.1 - 0.00019 21.6 0.9 0.1 12.7 0.1 3.1 3 1 1 4 4 4 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KII71789.1 - 0.00049 20.1 0.7 0.0071 16.4 0.1 3.0 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KII71789.1 - 0.00051 20.3 0.2 0.025 14.9 0.1 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 KII71789.1 - 0.0011 18.7 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 KII71789.1 - 0.0021 17.5 0.1 0.018 14.4 0.1 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 KII71789.1 - 0.0073 16.1 0.0 0.029 14.2 0.0 1.9 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 KII71789.1 - 0.0083 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein IstB_IS21 PF01695.17 KII71789.1 - 0.0083 15.9 0.1 0.026 14.3 0.1 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_7 PF12775.7 KII71789.1 - 0.01 15.4 0.0 0.04 13.4 0.0 1.9 1 1 1 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 KII71789.1 - 0.01 15.6 0.1 0.024 14.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KII71789.1 - 0.028 15.0 0.0 0.061 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KII71789.1 - 0.036 13.6 0.3 0.15 11.6 0.1 2.1 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 KII71789.1 - 0.042 14.0 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KII71789.1 - 0.061 12.7 0.1 0.21 10.9 0.0 1.9 1 1 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 KII71789.1 - 0.074 12.7 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 KII71789.1 - 0.1 13.0 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 KII71789.1 - 0.12 12.8 0.1 0.76 10.3 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_28 PF13521.6 KII71789.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KII71789.1 - 0.13 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 KII71789.1 - 0.16 11.8 0.4 4.7 7.1 0.0 2.5 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Acetyltransf_1 PF00583.25 KII71790.1 - 4.2e-10 39.9 0.0 5.7e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII71790.1 - 5.2e-08 32.9 0.0 6.8e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII71790.1 - 8.1e-08 32.6 0.0 1.3e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KII71790.1 - 0.0019 18.1 0.0 0.0041 17.0 0.0 1.4 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 KII71790.1 - 0.052 13.6 0.0 0.08 13.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 KII71790.1 - 0.054 13.0 0.0 0.068 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative acetyl-transferase Med29 PF11568.8 KII71792.1 - 0.0037 17.5 0.2 0.005 17.1 0.2 1.2 1 0 0 1 1 1 1 Mediator complex subunit 29 HTH_20 PF12840.7 KII71792.1 - 0.029 14.4 0.1 0.047 13.8 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Ig_4 PF16680.5 KII71792.1 - 0.034 14.4 0.4 0.068 13.4 0.4 1.5 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain RVT_1 PF00078.27 KII71793.1 - 2.3e-05 24.0 0.6 0.0044 16.5 0.1 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2650 PF10853.8 KII71795.1 - 0.19 11.5 1.9 0.24 11.1 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2650) Saf_2TM PF18303.1 KII71797.1 - 0.15 11.6 1.1 0.3 10.7 0.0 1.8 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain PDR_CDR PF06422.12 KII71797.1 - 0.34 10.8 1.6 0.44 10.5 0.1 1.9 2 1 1 3 3 3 0 CDR ABC transporter DHHC PF01529.20 KII71797.1 - 1.1 9.4 5.4 18 5.4 5.4 2.0 1 1 0 1 1 1 0 DHHC palmitoyltransferase DUF4795 PF16043.5 KII71799.1 - 0.12 11.9 2.1 7 6.2 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) RT_RNaseH_2 PF17919.1 KII71802.1 - 1.6e-34 117.9 0.0 8e-34 115.7 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71802.1 - 2.7e-34 118.6 0.1 5.5e-34 117.6 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII71802.1 - 1.2e-32 112.3 0.0 8.9e-32 109.5 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII71802.1 - 2.2e-20 73.0 0.0 7e-20 71.4 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71802.1 - 2.3e-18 66.1 0.4 6.7e-18 64.6 0.4 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII71802.1 - 8.6e-05 22.7 1.4 0.00073 19.7 0.0 2.8 3 0 0 3 3 3 1 H2C2 zinc finger rve_3 PF13683.6 KII71802.1 - 0.00017 21.3 0.2 0.0023 17.7 0.0 2.6 2 0 0 2 2 2 1 Integrase core domain Spuma_A9PTase PF03539.14 KII71802.1 - 0.0085 16.2 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) DUF2014 PF09427.10 KII71802.1 - 0.06 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) RVT_1 PF00078.27 KII71805.1 - 1e-06 28.4 0.2 2.5e-05 23.9 0.0 2.6 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII71805.1 - 0.0036 17.3 0.0 0.0065 16.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Dehydratase_MU PF02288.15 KII71805.1 - 0.059 13.3 0.1 0.13 12.2 0.1 1.6 1 1 0 1 1 1 0 Dehydratase medium subunit rve PF00665.26 KII71806.1 - 0.01 16.0 0.1 0.018 15.2 0.1 1.4 1 0 0 1 1 1 0 Integrase core domain DDE_3 PF13358.6 KII71808.1 - 3.9e-13 49.4 0.0 7.1e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease ANAPC_CDC26 PF10471.9 KII71808.1 - 0.072 13.9 0.3 0.11 13.3 0.3 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Edc3_linker PF16598.5 KII71811.1 - 0.065 13.9 2.5 0.48 11.1 0.3 2.4 2 1 0 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 rve PF00665.26 KII71815.1 - 1.9e-23 82.9 0.0 6e-23 81.3 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71815.1 - 7.5e-19 67.6 0.2 2.1e-18 66.2 0.2 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII71815.1 - 0.0013 18.5 0.0 0.0047 16.7 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII71815.1 - 0.058 13.6 0.0 0.21 11.9 0.0 1.9 2 0 0 2 2 2 0 H2C2 zinc finger VP_N-CPKC PF11475.8 KII71816.1 - 0.045 13.7 2.9 0.94 9.4 1.2 2.6 1 1 1 2 2 2 0 Virion protein N terminal domain DDE_Tnp_IS1595 PF12762.7 KII71816.1 - 0.051 13.6 1.4 0.081 12.9 0.2 1.8 1 1 1 2 2 2 0 ISXO2-like transposase domain zf-C2H2 PF00096.26 KII71816.1 - 3.4 8.3 9.1 1.8 9.2 0.7 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type PIF1 PF05970.14 KII71817.1 - 0.0012 18.2 0.1 0.0012 18.1 0.1 1.1 1 0 0 1 1 1 1 PIF1-like helicase COLFI PF01410.18 KII71817.1 - 0.067 12.5 0.2 0.07 12.4 0.2 1.0 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain MULE PF10551.9 KII71818.1 - 0.0023 18.3 0.1 0.0059 17.0 0.1 1.7 1 0 0 1 1 1 1 MULE transposase domain DUF505 PF04458.12 KII71818.1 - 0.17 10.3 0.7 0.2 10.0 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF505) DUF1564 PF07600.11 KII71819.1 - 0.045 13.4 0.1 0.06 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1564) DUF4129 PF13559.6 KII71820.1 - 0.0042 17.3 0.0 0.0064 16.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) rve PF00665.26 KII71821.1 - 1.6e-22 79.9 0.0 3.2e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71821.1 - 4.1e-21 74.8 0.2 8.7e-21 73.8 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII71821.1 - 0.0029 17.4 0.1 0.031 14.1 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII71821.1 - 0.0042 17.3 0.0 0.014 15.6 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger DDE_Tnp_IS240 PF13610.6 KII71821.1 - 0.014 15.6 0.0 0.044 14.0 0.0 1.8 1 0 0 1 1 1 0 DDE domain MLVIN_C PF18697.1 KII71821.1 - 0.12 12.5 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RT_RNaseH_2 PF17919.1 KII71822.1 - 1.8e-09 37.5 0.0 5.9e-09 35.9 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71822.1 - 1.4e-08 34.9 0.0 4.1e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71822.1 - 1.6e-06 27.8 0.0 4.2e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 KII71822.1 - 0.019 15.6 0.0 0.037 14.7 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 KII71822.1 - 0.16 12.6 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RT_RNaseH PF17917.1 KII71824.1 - 3.3e-14 53.0 0.0 5.7e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71824.1 - 8.4e-07 29.0 0.0 1.8e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase PDT PF00800.18 KII71824.1 - 0.045 13.6 0.1 0.072 12.9 0.1 1.2 1 0 0 1 1 1 0 Prephenate dehydratase RVT_1 PF00078.27 KII71825.1 - 3.9e-05 23.3 0.0 5.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_10 PF16588.5 KII71826.1 - 0.0094 15.7 9.3 0.019 14.7 1.3 2.5 2 0 0 2 2 2 2 C2H2 zinc-finger TRAF6_Z2 PF18048.1 KII71826.1 - 0.39 10.8 2.3 2.1 8.5 0.6 2.6 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 zf-CCHC PF00098.23 KII71826.1 - 1.1 9.5 10.2 1.7 8.8 2.3 2.4 2 0 0 2 2 2 0 Zinc knuckle RT_RNaseH_2 PF17919.1 KII71828.1 - 3e-28 97.8 0.0 4e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71828.1 - 6.8e-25 87.4 0.0 9e-25 87.0 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase CHASE4 PF05228.13 KII71828.1 - 0.016 15.5 0.0 0.017 15.3 0.0 1.1 1 0 0 1 1 1 0 CHASE4 domain Peptidase_A17 PF05380.13 KII71828.1 - 0.038 14.0 0.0 0.051 13.6 0.0 1.2 1 0 0 1 1 1 0 Pao retrotransposon peptidase RVT_1 PF00078.27 KII71829.1 - 0.0015 18.1 0.1 0.0019 17.8 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII71831.1 - 0.016 15.4 0.0 0.026 14.7 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain DDE_3 PF13358.6 KII71832.1 - 1.4e-06 28.2 0.0 2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII71832.1 - 0.018 15.3 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 Transposase HTH_33 PF13592.6 KII71832.1 - 0.023 14.3 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix Ribosomal_S21 PF01165.20 KII71832.1 - 0.074 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S21 HTH_23 PF13384.6 KII71832.1 - 0.11 12.4 0.0 3.5 7.5 0.0 2.7 2 0 0 2 2 2 0 Homeodomain-like domain RT_RNaseH_2 PF17919.1 KII71833.1 - 1e-09 38.3 0.0 1.7e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII71833.1 - 3.5e-05 23.4 0.1 5.2e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DNA_pol_viral_C PF00336.18 KII71833.1 - 0.00043 19.7 0.0 0.00059 19.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain RT_RNaseH PF17917.1 KII71833.1 - 0.11 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase DDE_3 PF13358.6 KII71835.1 - 1.7e-05 24.6 0.0 4e-05 23.4 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease Miga PF10265.9 KII71836.1 - 0.087 11.8 0.3 0.14 11.1 0.0 1.4 2 0 0 2 2 2 0 Mitoguardin RVT_1 PF00078.27 KII71839.1 - 1.5e-08 34.4 0.1 2e-08 34.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII71840.1 - 3.7e-19 69.1 0.0 5.6e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII71840.1 - 1.8e-07 31.1 0.8 2.9e-07 30.5 0.8 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII71840.1 - 0.0011 18.6 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain PocR PF10114.9 KII71840.1 - 0.052 13.3 0.1 0.093 12.5 0.1 1.3 1 0 0 1 1 1 0 Sensory domain found in PocR HTH_Tnp_Tc5 PF03221.16 KII71842.1 - 0.027 14.5 0.0 0.055 13.5 0.0 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain TFIIA_gamma_C PF02751.14 KII71844.1 - 0.06 13.5 0.5 0.25 11.5 0.1 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit Integrase_H2C2 PF17921.1 KII71847.1 - 1e-16 60.8 0.6 1e-16 60.8 0.6 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII71847.1 - 1.2e-13 51.3 0.0 2.3e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII71847.1 - 1.5e-05 25.1 0.5 6.8e-05 23.0 0.1 2.2 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII71847.1 - 0.00078 19.2 0.0 0.0021 17.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Baculo_RING PF05883.11 KII71854.1 - 0.0091 16.0 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain RT_RNaseH_2 PF17919.1 KII71856.1 - 2e-13 50.2 0.1 1.4e-06 28.2 0.0 2.5 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71856.1 - 4.5e-08 33.3 0.0 7.7e-07 29.4 0.0 2.2 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase SMP_2 PF10144.9 KII71858.1 - 0.15 11.7 0.3 2.7 7.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial virulence factor haemolysin KIP1 PF07765.12 KII71858.1 - 5.3 7.2 6.8 0.94 9.6 1.5 2.5 2 2 1 3 3 3 0 KIP1-like protein Integrase_H2C2 PF17921.1 KII71859.1 - 0.0046 17.0 0.1 0.012 15.7 0.0 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain Gemini_AL1_M PF08283.11 KII71860.1 - 0.029 14.5 0.1 0.45 10.6 0.1 2.4 1 1 1 2 2 2 0 Geminivirus rep protein central domain RVT_1 PF00078.27 KII71861.1 - 2.3e-29 102.5 0.1 1.2e-28 100.1 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII71861.1 - 1.1e-19 70.3 0.0 1.9e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII71861.1 - 8e-09 35.7 0.0 1.3e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF3640 PF12342.8 KII71862.1 - 6.2 6.7 5.4 1.1 9.1 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3640) Sulfotransfer_4 PF17784.1 KII71865.1 - 0.13 12.0 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain SNAP PF14938.6 KII71866.1 - 7.4e-14 51.8 4.1 1.2e-13 51.1 4.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NADH_4Fe-4S PF10589.9 KII71866.1 - 0.032 14.3 0.0 0.094 12.8 0.0 1.8 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region ATP-grasp_6 PF18419.1 KII71866.1 - 0.064 12.9 0.3 0.24 11.1 0.3 2.0 1 0 0 1 1 1 0 ATP-grasp-like domain MLVIN_C PF18697.1 KII71867.1 - 0.00012 22.1 0.8 0.00043 20.3 0.7 1.9 1 1 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RT_RNaseH PF17917.1 KII71868.1 - 2.5e-31 108.1 0.3 5.9e-31 106.9 0.3 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII71868.1 - 2.2e-30 104.6 0.1 6.4e-30 103.1 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII71868.1 - 1.4e-16 60.3 0.1 3.6e-16 59.0 0.1 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII71868.1 - 6.5e-16 58.6 0.0 1.7e-15 57.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 KII71868.1 - 2.5e-10 40.2 0.3 4.8e-10 39.3 0.3 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_3 PF13917.6 KII71869.1 - 0.011 15.7 9.8 0.014 15.4 2.3 2.4 1 1 1 2 2 2 0 Zinc knuckle RVP PF00077.20 KII71869.1 - 0.067 13.5 0.1 0.18 12.2 0.0 1.7 2 0 0 2 2 2 0 Retroviral aspartyl protease PRIMA1 PF16101.5 KII71870.1 - 0.01 15.9 0.5 0.015 15.3 0.5 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Glypican PF01153.19 KII71871.1 - 0.14 11.0 2.6 0.17 10.7 2.6 1.1 1 0 0 1 1 1 0 Glypican SF3b10 PF07189.11 KII71872.1 - 0.046 13.8 0.0 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 Splicing factor 3B subunit 10 (SF3b10) DDE_3 PF13358.6 KII71875.1 - 1.2e-06 28.4 0.0 2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 KII71875.1 - 0.029 15.0 0.0 0.063 13.9 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Peptidase_S9 PF00326.21 KII71879.1 - 8e-20 71.2 0.0 1.2e-12 47.7 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KII71879.1 - 8e-09 35.5 0.4 1.7e-06 27.9 0.3 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KII71879.1 - 3.3e-08 33.1 0.0 0.00055 19.3 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 KII71879.1 - 2.5e-06 27.2 0.0 3.6e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S28 PF05577.12 KII71879.1 - 0.00038 19.4 0.0 0.0016 17.3 0.0 1.8 2 0 0 2 2 2 1 Serine carboxypeptidase S28 Abhydrolase_2 PF02230.16 KII71879.1 - 0.0011 18.8 0.0 0.0016 18.3 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 KII71879.1 - 0.0066 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Tannase PF07519.11 KII71879.1 - 0.021 13.8 0.0 0.037 12.9 0.0 1.3 1 0 0 1 1 1 0 Tannase and feruloyl esterase Abhydrolase_6 PF12697.7 KII71879.1 - 0.086 13.4 0.0 0.52 10.9 0.0 1.8 1 1 1 2 2 2 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 KII71879.1 - 0.1 12.2 0.0 1 8.9 0.0 2.0 1 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) COesterase PF00135.28 KII71879.1 - 0.11 11.3 0.1 0.19 10.6 0.1 1.3 1 0 0 1 1 1 0 Carboxylesterase family Dimer_Tnp_hAT PF05699.14 KII71888.1 - 0.00031 20.5 0.3 0.00045 20.0 0.3 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Orthoreo_P17 PF07272.11 KII71890.1 - 0.014 15.4 2.1 0.96 9.5 0.5 2.1 2 0 0 2 2 2 0 Orthoreovirus P17 protein TCL1_MTCP1 PF01840.17 KII71890.1 - 0.034 13.8 0.3 0.048 13.3 0.3 1.3 1 0 0 1 1 1 0 TCL1/MTCP1 family DUF1681 PF07933.14 KII71895.1 - 2.6e-15 56.4 0.0 3.3e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Ig_3 PF13927.6 KII71896.1 - 0.75 10.4 4.3 4.7 7.9 4.3 2.4 1 1 0 1 1 1 0 Immunoglobulin domain RnaseA PF00074.20 KII71896.1 - 1.5 9.3 7.8 0.18 12.3 3.0 1.9 2 0 0 2 2 2 0 Pancreatic ribonuclease Peptidase_C1 PF00112.23 KII71897.1 - 2.2e-13 50.8 0.0 3.5e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII71897.1 - 1.6e-09 38.0 2.9 2.7e-09 37.3 2.9 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.23 KII71898.1 - 2.2e-49 168.5 0.0 3.5e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII71898.1 - 5.5e-10 39.5 3.8 1.2e-09 38.5 3.8 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C39_2 PF13529.6 KII71898.1 - 0.016 15.8 0.1 0.035 14.7 0.0 1.6 2 0 0 2 2 2 0 Peptidase_C39 like family Glyco_transf_10 PF00852.19 KII71899.1 - 7.9e-40 136.4 1.9 7.9e-40 136.4 1.9 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 KII71899.1 - 0.00014 22.3 2.1 0.00045 20.6 0.1 2.6 3 0 0 3 3 3 1 Fucosyltransferase, N-terminal DUF4450 PF14614.6 KII71899.1 - 0.026 14.1 0.1 0.063 12.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4450) Glyco_transf_10 PF00852.19 KII71900.1 - 1.9e-37 128.7 1.2 1.9e-37 128.7 1.2 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 KII71900.1 - 0.00011 22.6 1.9 0.00044 20.7 0.1 2.6 3 0 0 3 3 3 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 KII71901.1 - 6.1e-13 48.9 0.2 7.1e-13 48.6 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Cir_Bir_Yir PF06022.11 KII71902.1 - 0.01 15.4 0.5 0.01 15.4 0.5 1.7 2 0 0 2 2 2 0 Plasmodium variant antigen protein Cir/Yir/Bir ATP-synt_8 PF00895.20 KII71902.1 - 8 7.0 7.2 0.22 12.0 0.5 1.9 2 0 0 2 2 2 0 ATP synthase protein 8 API5 PF05918.11 KII71903.1 - 6.8e-05 21.9 0.0 8.1e-05 21.6 0.0 1.1 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) Lig_C PF18330.1 KII71903.1 - 0.019 15.0 0.4 0.028 14.4 0.4 1.2 1 0 0 1 1 1 0 Ligase Pab1020 C-terminal region Fip1 PF05182.13 KII71904.1 - 1.4e-21 75.7 2.2 2.5e-21 74.9 2.2 1.4 1 0 0 1 1 1 1 Fip1 motif Transformer PF06495.11 KII71904.1 - 0.0011 19.1 13.7 0.0018 18.4 13.7 1.4 1 0 0 1 1 1 1 Fruit fly transformer protein GST_C PF00043.25 KII71905.1 - 0.00017 21.8 0.0 0.00054 20.1 0.0 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KII71905.1 - 0.0027 17.9 0.0 0.0054 16.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 KII71905.1 - 0.0083 15.9 0.0 0.024 14.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KII71905.1 - 0.016 15.2 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain AA_permease_2 PF13520.6 KII71906.1 - 3.3e-45 154.7 38.6 3.3e-45 154.7 38.6 2.4 2 1 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 KII71906.1 - 3.5e-34 118.2 36.0 3.5e-34 118.2 36.0 2.7 2 1 1 3 3 3 2 Amino acid permease AA_permease_C PF13906.6 KII71906.1 - 8.1e-13 48.2 15.5 8.1e-13 48.2 15.5 4.6 4 1 0 4 4 4 1 C-terminus of AA_permease DUF4094 PF13334.6 KII71906.1 - 0.24 11.8 1.8 0.68 10.4 1.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF4293 PF14126.6 KII71906.1 - 5.9 7.1 21.0 0.1 12.8 10.2 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4293) NAGidase PF07555.13 KII71907.1 - 7.6e-72 242.1 0.0 1.2e-71 241.5 0.0 1.3 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase Sir1 PF11603.8 KII71910.1 - 0.043 14.3 4.7 0.057 13.9 4.7 1.4 1 0 0 1 1 1 0 Regulatory protein Sir1 Laminin_II PF06009.12 KII71910.1 - 0.062 13.3 2.7 0.091 12.8 2.7 1.3 1 0 0 1 1 1 0 Laminin Domain II Rx_N PF18052.1 KII71910.1 - 0.18 12.1 2.8 0.62 10.4 2.7 1.9 1 1 0 1 1 1 0 Rx N-terminal domain Elf4 PF07011.11 KII71910.1 - 0.27 11.2 5.7 1.4 8.9 3.0 2.4 2 1 0 2 2 2 0 Early Flowering 4 domain HEM4 PF02602.15 KII71914.1 - 1.5e-15 57.2 0.0 1.9e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD PGG PF13962.6 KII71915.1 - 0.022 14.6 2.0 0.022 14.6 2.0 1.6 2 0 0 2 2 2 0 Domain of unknown function Phage_integr_3 PF16795.5 KII71915.1 - 0.13 12.2 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Archaeal phage integrase Transgly_assoc PF04226.13 KII71915.1 - 9.5 6.6 10.8 5.2 7.4 1.8 2.5 2 1 0 2 2 2 0 Transglycosylase associated protein MA3 PF02847.17 KII71920.1 - 1.3e-05 25.2 1.1 1.3e-05 25.2 1.1 3.2 3 1 1 4 4 4 1 MA3 domain FadA PF09403.10 KII71920.1 - 0.069 13.6 1.8 0.22 12.1 1.8 1.9 1 0 0 1 1 1 0 Adhesion protein FadA Sld7_C PF18596.1 KII71920.1 - 0.16 12.1 2.1 14 5.9 0.1 3.2 3 1 0 3 3 3 0 Sld7 C-terminal domain Sld7_N PF18636.1 KII71921.1 - 0.0036 17.6 0.1 0.0051 17.1 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial morphogenesis protein SLD7 N-terminal domain DUF1947 PF09183.10 KII71921.1 - 0.016 15.5 0.4 0.052 13.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) DDE_Tnp_IS1595 PF12762.7 KII71925.1 - 0.001 19.1 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_Tnp_IS1595 PF12760.7 KII71925.1 - 0.005 16.8 1.6 0.011 15.7 1.6 1.6 1 0 0 1 1 1 1 Transposase zinc-ribbon domain IBR PF01485.21 KII71925.1 - 0.074 13.3 0.7 0.074 13.3 0.7 1.7 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-C4_Topoisom PF01396.19 KII71925.1 - 0.12 12.1 5.5 0.24 11.2 5.5 1.5 1 0 0 1 1 1 0 Topoisomerase DNA binding C4 zinc finger zf-ACC PF17848.1 KII71925.1 - 1.6 8.8 6.5 0.16 12.1 1.1 2.1 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Hemocyanin_N PF03722.14 KII71927.1 - 0.0066 17.0 0.4 0.011 16.2 0.3 1.5 1 1 0 1 1 1 1 Hemocyanin, all-alpha domain MULE PF10551.9 KII71928.1 - 2e-15 57.0 0.1 2.5e-13 50.3 0.1 2.4 2 0 0 2 2 2 2 MULE transposase domain FLYWCH PF04500.16 KII71928.1 - 1.9e-14 53.5 3.8 1.9e-14 53.5 3.8 1.8 2 0 0 2 2 2 1 FLYWCH zinc finger domain Zn_ribbon_recom PF13408.6 KII71928.1 - 0.57 10.7 6.1 1.2 9.7 6.1 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF489 PF04356.12 KII71929.1 - 0.0059 16.6 0.1 0.007 16.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF489) FliJ PF02050.16 KII71929.1 - 0.022 15.0 0.8 0.21 11.8 0.1 2.1 1 1 1 2 2 2 0 Flagellar FliJ protein PRESAN PF09687.10 KII71929.1 - 0.031 14.8 8.6 0.49 11.0 3.3 2.2 1 1 1 2 2 2 0 Plasmodium RESA N-terminal Prominin PF05478.11 KII71929.1 - 0.083 10.8 1.0 0.094 10.7 1.0 1.1 1 0 0 1 1 1 0 Prominin DUF4250 PF14056.6 KII71929.1 - 0.093 12.7 1.1 0.96 9.4 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) Cytochrom_B562 PF07361.11 KII71929.1 - 0.13 13.0 0.4 0.84 10.3 0.1 2.1 1 1 1 2 2 2 0 Cytochrome b562 Fib_alpha PF08702.10 KII71929.1 - 0.16 12.2 3.5 0.32 11.2 2.2 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF16 PF01519.16 KII71929.1 - 0.51 10.8 4.4 0.69 10.4 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Proteasome PF00227.26 KII71931.1 - 4.5e-34 117.6 0.0 5.1e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DASH_Ask1 PF08655.10 KII71933.1 - 5.4 7.0 10.6 11 6.0 0.1 3.7 4 1 0 4 4 4 0 DASH complex subunit Ask1 zf-BED PF02892.15 KII71934.1 - 0.055 13.5 0.4 0.13 12.3 0.1 1.8 2 0 0 2 2 2 0 BED zinc finger ATP_bind_3 PF01171.20 KII71936.1 - 4.5e-05 23.3 0.0 7.4e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 PP-loop family Zn_ribbon_SprT PF17283.2 KII71936.1 - 0.032 14.1 1.8 0.046 13.6 1.8 1.2 1 0 0 1 1 1 0 SprT-like zinc ribbon domain PAPS_reduct PF01507.19 KII71936.1 - 0.037 14.1 0.0 0.055 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family NAD_synthase PF02540.17 KII71936.1 - 0.04 13.0 0.0 0.045 12.9 0.0 1.1 1 0 0 1 1 1 0 NAD synthase tRNA_Me_trans PF03054.16 KII71936.1 - 0.046 12.5 0.0 0.078 11.7 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase IRF-2BP1_2 PF11261.8 KII71936.1 - 0.26 10.9 4.5 2.6 7.7 4.5 2.1 1 1 0 1 1 1 0 Interferon regulatory factor 2-binding protein zinc finger 2-oxogl_dehyd_N PF16078.5 KII71937.1 - 0.056 13.0 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase N-terminus Use1 PF09753.9 KII71939.1 - 0.0044 16.8 5.2 0.0061 16.3 5.2 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 Hanta_nucleocap PF00846.18 KII71939.1 - 0.036 12.5 0.5 0.045 12.2 0.3 1.3 1 1 0 1 1 1 0 Hantavirus nucleocapsid protein DUF4337 PF14235.6 KII71939.1 - 0.55 10.3 3.1 1 9.4 3.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) GTP_EFTU PF00009.27 KII71942.1 - 1.3e-12 47.7 0.0 1.1e-11 44.6 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KII71942.1 - 2.7e-09 37.3 0.2 8.3e-09 35.7 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 KII71942.1 - 0.0014 18.9 0.6 0.008 16.5 0.2 2.4 2 1 0 2 2 2 1 Elongation factor Tu C-terminal domain PduV-EutP PF10662.9 KII71942.1 - 0.11 12.2 0.2 5.7 6.7 0.0 2.5 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Lipase_GDSL_2 PF13472.6 KII71942.1 - 0.15 12.4 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DHO_dh PF01180.21 KII71943.1 - 1.4e-46 159.1 0.0 1.8e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 KII71943.1 - 0.0019 17.6 0.0 0.003 17.0 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 KII71943.1 - 0.003 16.7 0.0 0.0055 15.8 0.0 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Asparaginase PF00710.20 KII71943.1 - 0.059 12.9 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 Asparaginase, N-terminal IMPDH PF00478.25 KII71943.1 - 0.068 12.2 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain TetR_N PF00440.23 KII71945.1 - 3.6e-14 52.3 0.1 6.9e-14 51.4 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Oxidored_FMN PF00724.20 KII71946.1 - 3.9e-65 220.4 0.0 7.6e-65 219.4 0.0 1.5 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family adh_short PF00106.25 KII71946.1 - 9e-43 146.0 0.1 1.4e-42 145.4 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII71946.1 - 1.3e-28 100.1 0.4 2.1e-28 99.5 0.4 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII71946.1 - 1.8e-13 50.8 0.2 3.2e-13 50.0 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KII71946.1 - 0.0012 18.3 0.1 0.0021 17.6 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KII71946.1 - 0.06 13.2 0.4 0.12 12.2 0.4 1.5 1 0 0 1 1 1 0 NAD(P)H-binding RET_CLD3 PF17812.1 KII71947.1 - 0.12 12.7 0.1 0.33 11.2 0.2 1.6 2 0 0 2 2 2 0 RET Cadherin like domain 3 ERGIC_N PF13850.6 KII71948.1 - 0.087 13.2 0.8 0.17 12.3 0.1 1.8 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) RRM_2 PF04059.12 KII71949.1 - 0.21 11.8 6.4 0.11 12.7 1.5 2.7 2 2 1 3 3 3 0 RNA recognition motif 2 Ribosomal_L28 PF00830.19 KII71949.1 - 4 7.7 6.3 1.3 9.3 1.1 2.7 2 1 0 2 2 2 0 Ribosomal L28 family BTP PF05232.12 KII71950.1 - 3.4e-16 59.0 1.1 5.9e-11 42.3 0.0 2.2 2 0 0 2 2 2 2 Chlorhexidine efflux transporter HHA PF05321.11 KII71950.1 - 3.5e-14 52.8 0.0 4.9e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Haemolysin expression modulating protein ABC_ATPase PF09818.9 KII71951.1 - 0.11 11.3 1.8 0.12 11.1 1.8 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Autotransporter PF03797.19 KII71952.1 - 2.3e-35 122.5 16.0 3.1e-35 122.0 16.0 1.1 1 0 0 1 1 1 1 Autotransporter beta-domain BOF PF04076.13 KII71953.1 - 3.5e-16 59.1 1.8 4.6e-16 58.7 1.8 1.1 1 0 0 1 1 1 1 Bacterial OB fold (BOF) protein tRNA_anti-codon PF01336.25 KII71953.1 - 0.0037 17.2 1.1 0.0068 16.4 0.9 1.6 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4431 PF14485.6 KII71953.1 - 0.0049 16.6 0.1 0.049 13.4 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4431) DNA_pol_D_N PF18018.1 KII71953.1 - 0.031 14.4 0.2 0.048 13.8 0.2 1.4 1 1 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain DUF4131 PF13567.6 KII71953.1 - 0.19 11.4 0.0 0.48 10.1 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) GerE PF00196.19 KII71954.1 - 3.1e-09 36.2 0.1 5.5e-09 35.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_7 PF02796.15 KII71954.1 - 0.0003 20.8 0.1 0.00064 19.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 KII71954.1 - 0.004 16.9 0.0 0.0073 16.1 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_40 PF14493.6 KII71954.1 - 0.0099 16.3 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 KII71954.1 - 0.011 15.9 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_38 PF13936.6 KII71954.1 - 0.064 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII71954.1 - 0.071 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 Terminase_5 PF06056.12 KII71954.1 - 0.12 12.3 0.0 0.43 10.5 0.0 1.8 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_29 PF13551.6 KII71954.1 - 0.15 12.1 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix HTH_46 PF15977.5 KII71955.1 - 1.2e-08 34.8 0.0 3.1e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA binding MarR_2 PF12802.7 KII71955.1 - 0.12 12.2 0.0 0.33 10.9 0.0 1.7 2 0 0 2 2 2 0 MarR family LNS2 PF08235.13 KII71959.1 - 3.5e-80 268.7 0.0 5.2e-80 268.1 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 KII71959.1 - 8.7e-29 99.5 0.0 1.7e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 KII71959.1 - 2.6e-06 27.5 0.0 7.7e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain NTF2 PF02136.20 KII71960.1 - 4.9e-10 40.0 0.0 5.3e-10 39.9 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 KII71960.1 - 0.021 15.2 0.0 0.023 15.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) HTH_Tnp_Tc5 PF03221.16 KII71961.1 - 9.9e-10 38.3 0.1 1.6e-09 37.7 0.1 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 KII71961.1 - 0.00019 21.0 0.4 0.00048 19.7 0.4 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_3 PF01381.22 KII71961.1 - 0.0015 18.6 0.3 0.012 15.6 0.0 2.5 3 0 0 3 3 3 1 Helix-turn-helix HTH_psq PF05225.16 KII71961.1 - 0.0046 16.7 0.3 0.011 15.5 0.1 1.7 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 KII71961.1 - 0.0051 16.6 0.1 0.023 14.5 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain LacI PF00356.21 KII71961.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_IclR PF09339.10 KII71961.1 - 0.028 14.2 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_38 PF13936.6 KII71961.1 - 0.034 13.9 0.2 0.076 12.8 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain DUF4371 PF14291.6 KII71963.1 - 0.016 14.8 0.4 0.037 13.7 0.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4371) NrfD PF03916.14 KII71965.1 - 0.0085 15.8 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 1 Polysulphide reductase, NrfD DBD_Tnp_Hermes PF10683.9 KII71965.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain DDE_Tnp_IS1595 PF12762.7 KII71967.1 - 0.015 15.3 0.0 0.018 15.0 0.0 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain C1_4 PF07975.12 KII71968.1 - 8.3e-05 22.8 27.6 0.00047 20.3 16.3 3.1 2 1 0 2 2 2 2 TFIIH C1-like domain DZR PF12773.7 KII71968.1 - 0.00054 19.9 15.9 0.0068 16.4 6.8 2.5 2 1 0 2 2 2 2 Double zinc ribbon zf-HIT PF04438.16 KII71968.1 - 0.0025 17.7 1.9 0.0025 17.7 1.9 4.7 4 1 0 4 4 4 1 HIT zinc finger zf-AN1 PF01428.16 KII71968.1 - 0.039 14.1 7.1 0.039 14.1 7.1 4.2 2 2 3 5 5 5 0 AN1-like Zinc finger HscB_4_cys PF18256.1 KII71968.1 - 0.41 10.5 0.4 0.41 10.5 0.4 3.9 4 1 0 4 4 4 0 Co-chaperone HscB tetracysteine metal binding motif zinc_ribbon_15 PF17032.5 KII71968.1 - 0.42 11.4 19.9 67 4.3 19.9 2.6 1 1 0 1 1 1 0 zinc-ribbon family IBR PF01485.21 KII71968.1 - 2.6 8.3 21.8 0.047 13.9 7.4 2.8 2 2 0 2 2 2 0 IBR domain, a half RING-finger domain zf-B_box PF00643.24 KII71968.1 - 3.1 8.0 25.2 0.16 12.2 7.9 3.6 3 1 1 4 4 4 0 B-box zinc finger Ssl1 PF04056.14 KII71969.1 - 3.2e-49 167.4 0.4 3.9e-49 167.1 0.4 1.1 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 KII71969.1 - 3.7e-15 56.5 0.1 6.2e-15 55.8 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 KII71969.1 - 3.8e-10 40.3 0.2 5.8e-10 39.7 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF1778 PF08681.11 KII71974.1 - 8.5e-24 83.3 1.3 1.8e-23 82.3 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1778) Acetyltransf_10 PF13673.7 KII71974.1 - 5.2e-09 36.1 0.0 2.4e-08 34.0 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII71974.1 - 8e-08 32.6 0.0 1.6e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KII71974.1 - 2.4e-06 27.8 0.0 3.9e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family CC2-LZ PF16516.5 KII71976.1 - 0.015 15.7 0.2 0.015 15.7 0.2 1.6 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PcF PF09461.10 KII71979.1 - 1.8 9.0 4.5 37 4.8 1.4 2.4 2 0 0 2 2 2 0 Phytotoxin PcF protein DUF4129 PF13559.6 KII71981.1 - 0.007 16.6 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) zf-CCHC PF00098.23 KII71981.1 - 0.021 14.9 0.5 0.048 13.8 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle Lysyl_oxidase PF01186.17 KII71982.1 - 0.0071 16.0 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Lysyl oxidase ERGIC_N PF13850.6 KII71982.1 - 0.04 14.3 0.3 0.18 12.2 0.1 2.2 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) KH_10 PF17905.1 KII71983.1 - 0.12 12.8 0.0 0.15 12.5 0.0 1.1 1 0 0 1 1 1 0 GLD-3 KH domain 5 Ldl_recept_a PF00057.18 KII71984.1 - 2.6e-28 97.9 52.5 6.1e-12 45.5 11.9 3.7 2 1 2 4 4 4 3 Low-density lipoprotein receptor domain class A Adhesin_E PF16747.5 KII71985.1 - 0.023 14.8 3.9 0.27 11.3 0.1 3.2 3 0 0 3 3 3 0 Surface-adhesin protein E Arm-DNA-bind_5 PF17293.2 KII71986.1 - 0.029 14.8 1.2 0.038 14.4 0.3 1.6 2 0 0 2 2 2 0 Arm DNA-binding domain Flavokinase PF01687.17 KII71987.1 - 3.7e-05 24.0 0.9 0.00037 20.8 0.9 2.0 1 1 0 1 1 1 1 Riboflavin kinase DUF512 PF04459.12 KII71987.1 - 0.014 14.7 0.1 0.037 13.3 0.0 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF512) Holin_BhlA PF10960.8 KII71988.1 - 0.064 13.2 0.7 0.11 12.5 0.6 1.4 1 1 0 1 1 1 0 BhlA holin family Ribosomal_L7Ae PF01248.26 KII71990.1 - 3.7e-21 74.6 0.0 6.1e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PLAC8 PF04749.17 KII71992.1 - 8.2e-12 46.0 4.6 9.6e-12 45.8 4.6 1.1 1 0 0 1 1 1 1 PLAC8 family DUF3738 PF12543.8 KII71993.1 - 0.079 13.1 0.0 0.089 12.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) HSP20 PF00011.21 KII71994.1 - 1.6e-16 60.3 0.3 2.7e-07 30.7 0.1 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family Ribosomal_L17 PF01196.19 KII71996.1 - 0.015 16.1 0.0 0.032 15.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L17 Kelch_4 PF13418.6 KII71998.1 - 4.7e-23 80.9 6.7 5.4e-05 23.1 0.0 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII71998.1 - 9e-22 76.4 5.7 0.00025 20.6 0.1 5.1 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KII71998.1 - 1.8e-21 75.6 14.7 3.6e-05 23.9 0.0 6.4 5 2 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KII71998.1 - 4.5e-18 64.5 4.5 6.9e-05 22.7 0.0 6.0 5 1 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII71998.1 - 3.7e-17 62.2 4.1 0.00014 22.1 0.0 5.3 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII71998.1 - 2e-15 56.4 6.4 0.0014 18.6 0.0 5.5 6 0 0 6 6 6 4 Kelch motif Lig_C PF18330.1 KII72006.1 - 0.034 14.1 0.0 0.048 13.7 0.0 1.2 1 0 0 1 1 1 0 Ligase Pab1020 C-terminal region PfkB PF00294.24 KII72008.1 - 1.6e-52 178.7 0.1 1.8e-52 178.6 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase BsuBI_PstI_RE PF06616.11 KII72008.1 - 0.022 14.0 0.0 0.048 13.0 0.0 1.5 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease domain Shisa PF13908.6 KII72009.1 - 0.0074 16.6 1.7 0.0087 16.3 1.1 1.4 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Slu7 PF11708.8 KII72011.1 - 0.0048 16.7 0.4 0.0074 16.1 0.4 1.4 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor Dimer_Tnp_hAT PF05699.14 KII72012.1 - 0.0002 21.1 0.2 0.00057 19.6 0.2 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4461 PF14688.6 KII72012.1 - 0.0096 15.7 0.1 0.022 14.5 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4461) DUF2002 PF09400.10 KII72012.1 - 0.024 14.7 0.0 0.049 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2002) DUF4681 PF15732.5 KII72012.1 - 0.11 12.7 0.1 0.28 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4681) CxxCxxCC PF03692.15 KII72012.1 - 0.2 12.4 0.7 9.3 7.0 0.0 2.8 3 0 0 3 3 3 0 Putative zinc- or iron-chelating domain Cation_efflux PF01545.21 KII72013.1 - 1.7e-23 83.4 13.8 2e-23 83.2 13.8 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 KII72013.1 - 2.7e-09 37.0 0.7 9.3e-09 35.3 0.1 2.1 3 0 0 3 3 3 1 Dimerisation domain of Zinc Transporter Dymeclin PF09742.9 KII72014.1 - 1.6e-06 26.9 11.0 2e-06 26.6 11.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Glu_synthase PF01645.17 KII72014.1 - 0.074 12.2 0.2 0.11 11.7 0.2 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase SIL1 PF16782.5 KII72016.1 - 0.00012 21.5 0.5 0.00023 20.5 0.4 1.6 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 Fes1 PF08609.10 KII72016.1 - 0.077 13.9 0.6 0.39 11.6 0.1 2.2 1 1 1 2 2 2 0 Nucleotide exchange factor Fes1 FYVE PF01363.21 KII72017.1 - 7e-11 42.1 19.3 4.5e-10 39.5 19.3 2.1 1 1 0 1 1 1 1 FYVE zinc finger UNC-79 PF14776.6 KII72017.1 - 3.5 6.3 11.1 4.8 5.8 11.1 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 PB1 PF00564.24 KII72018.1 - 1.5e-10 40.9 0.1 2.5e-10 40.1 0.1 1.4 1 0 0 1 1 1 1 PB1 domain SepF PF04472.12 KII72021.1 - 0.032 14.5 0.0 0.057 13.7 0.0 1.4 1 0 0 1 1 1 0 Cell division protein SepF Tubulin-binding PF00418.19 KII72025.1 - 0.093 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat zf-DBF PF07535.12 KII72025.1 - 0.21 11.7 0.3 0.35 11.0 0.3 1.3 1 0 0 1 1 1 0 DBF zinc finger WD40 PF00400.32 KII72026.1 - 7.9e-05 23.4 6.4 0.049 14.5 0.1 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat Nup160 PF11715.8 KII72026.1 - 0.00041 19.1 0.9 1.3 7.6 0.0 3.1 3 0 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 KII72026.1 - 0.025 13.9 1.8 0.075 12.3 0.8 1.8 1 1 1 2 2 2 0 WD40-like domain PQQ_3 PF13570.6 KII72026.1 - 0.072 13.6 0.0 15 6.3 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain Asp5 PF17000.5 KII72027.1 - 0.096 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Accessory secretory protein Sec, Asp5 RT_RNaseH_2 PF17919.1 KII72028.1 - 2.2e-09 37.3 0.0 5.6e-09 35.9 0.0 1.6 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72028.1 - 1.5e-07 31.6 0.5 4e-07 30.3 0.0 1.9 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72029.1 - 1e-31 108.9 0.0 1.7e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72029.1 - 2.3e-26 92.1 0.0 4.8e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72029.1 - 2.6e-08 33.7 0.2 6.5e-08 32.4 0.1 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNA_lig_T4_1 PF09511.10 KII72029.1 - 0.084 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA ligase iPGM_N PF06415.13 KII72029.1 - 0.2 11.1 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 BPG-independent PGAM N-terminus (iPGM_N) DDE_1 PF03184.19 KII72030.1 - 0.0064 16.2 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII72030.1 - 0.047 13.7 0.5 0.074 13.1 0.5 1.3 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain GlutR_dimer PF00745.20 KII72031.1 - 0.03 14.7 0.1 0.048 14.1 0.1 1.4 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain FragX_IP PF05994.11 KII72032.1 - 1.9e-66 224.8 0.3 2.4e-66 224.5 0.3 1.0 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family Sortilin_C PF15901.5 KII72035.1 - 3.7e-12 46.9 1.9 4.8e-12 46.6 1.9 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal RasGEF_N_2 PF14663.6 KII72037.1 - 0.035 14.5 0.0 0.21 12.0 0.0 1.9 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain CLU PF13236.6 KII72039.1 - 8.8e-67 225.2 0.0 1.4e-66 224.5 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 KII72039.1 - 1e-39 136.4 0.0 2.9e-39 134.9 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 KII72039.1 - 1.9e-11 44.2 0.4 5.5e-11 42.7 0.4 1.9 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.6 KII72039.1 - 1.3e-09 38.2 0.4 5.5e-08 33.0 0.1 2.5 1 1 2 3 3 3 2 Tetratricopeptide repeat DUF727 PF05303.12 KII72039.1 - 1.7e-05 24.8 0.0 6.2e-05 23.0 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_10 PF13374.6 KII72039.1 - 0.0071 16.2 0.5 3.9 7.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Kelch_4 PF13418.6 KII72041.1 - 0.0014 18.6 1.0 0.0052 16.8 0.2 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KII72041.1 - 0.0019 18.4 3.6 0.017 15.4 0.1 3.0 3 1 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 KII72041.1 - 0.0046 17.2 0.4 0.18 12.1 0.1 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII72041.1 - 0.15 11.6 3.0 10 5.8 0.0 3.2 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 KII72042.1 - 9.6e-09 35.2 0.5 2.9e-06 27.3 0.2 2.6 2 1 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII72042.1 - 0.00042 20.2 0.6 0.07 13.1 0.2 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 KII72042.1 - 0.0037 17.2 0.4 0.0085 16.1 0.1 1.7 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 KII72042.1 - 0.028 14.0 2.3 3.9 7.2 0.3 2.4 2 0 0 2 2 2 0 Kelch motif Desulfoferrodox PF01880.18 KII72042.1 - 0.12 13.0 0.1 0.15 12.7 0.1 1.2 1 0 0 1 1 1 0 Desulfoferrodoxin Kelch_4 PF13418.6 KII72043.1 - 0.0004 20.3 0.9 0.001 19.0 0.1 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 KII72043.1 - 0.0083 16.4 0.1 0.12 12.7 0.0 2.3 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII72043.1 - 0.0093 15.5 0.8 0.17 11.5 0.1 2.5 2 1 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 KII72043.1 - 0.087 13.1 1.7 5 7.6 0.2 2.5 1 1 1 2 2 2 0 Kelch motif Integrase_H2C2 PF17921.1 KII72044.1 - 3e-10 40.0 0.2 3.9e-10 39.7 0.2 1.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII72044.1 - 0.0048 17.1 0.0 0.0069 16.6 0.0 1.3 1 0 0 1 1 1 1 H2C2 zinc finger zf-H3C2 PF16721.5 KII72044.1 - 0.16 12.3 0.0 0.2 12.0 0.0 1.1 1 0 0 1 1 1 0 Zinc-finger like, probable DNA-binding Importin_rep_3 PF18806.1 KII72045.1 - 0.12 12.5 0.0 1.5 8.9 0.0 2.8 2 0 0 2 2 2 0 Importin 13 repeat Kelch_6 PF13964.6 KII72046.1 - 1.9e-16 59.7 15.1 0.0012 19.1 0.3 6.0 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 KII72046.1 - 5.4e-10 39.0 5.1 0.0019 18.1 0.1 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KII72046.1 - 2.5e-09 36.6 10.2 0.018 14.6 0.0 6.6 7 0 0 7 7 7 3 Kelch motif Kelch_2 PF07646.15 KII72046.1 - 1.7e-08 34.1 5.6 0.015 15.3 0.1 5.6 6 1 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 KII72046.1 - 2.4e-08 33.9 13.9 0.0096 15.9 0.1 6.3 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_3 PF13415.6 KII72046.1 - 3.7e-06 27.1 8.2 0.041 14.2 0.0 5.0 5 1 0 5 5 5 2 Galactose oxidase, central domain DUF1374 PF07118.11 KII72048.1 - 0.028 14.9 0.1 0.084 13.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1374) YdaS_antitoxin PF15943.5 KII72048.1 - 0.085 12.7 0.7 5.9 6.8 0.1 2.3 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT SNAP PF14938.6 KII72049.1 - 6.6e-05 22.5 1.0 7.7e-05 22.2 1.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP HTH_Tnp_Tc5 PF03221.16 KII72051.1 - 3.1e-09 36.7 0.5 4.8e-09 36.1 0.5 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF2315 PF10231.9 KII72051.1 - 0.023 14.8 0.3 0.032 14.3 0.3 1.3 1 0 0 1 1 1 0 Apoptogenic protein 1 DDE_1 PF03184.19 KII72052.1 - 4.7e-28 98.0 0.1 5e-26 91.4 0.1 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease Ufd2P_core PF10408.9 KII72053.1 - 2.1e-28 99.3 0.6 2.5e-28 99.1 0.6 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 KII72053.1 - 5.9e-15 55.2 0.4 1.1e-14 54.3 0.4 1.5 1 0 0 1 1 1 1 U-box domain Ufd2P_core PF10408.9 KII72054.1 - 6.7e-11 41.5 0.1 7.1e-11 41.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core RT_RNaseH_2 PF17919.1 KII72055.1 - 3.9e-24 84.6 0.0 6.9e-24 83.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72055.1 - 1.1e-18 67.4 0.0 1.6e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Peptidase_A17 PF05380.13 KII72055.1 - 0.0068 16.4 0.0 0.0092 16.0 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase HA70_C PF17993.1 KII72055.1 - 0.054 13.6 0.0 0.063 13.3 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin 70 C-terminal domain RVT_1 PF00078.27 KII72056.1 - 2.1e-09 37.2 0.1 3.5e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72057.1 - 1.1e-08 35.3 0.0 4.7e-06 26.8 0.0 2.3 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII72057.1 - 0.0044 16.8 0.1 0.01 15.6 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII72060.1 - 6.9e-05 22.6 0.0 0.0001 22.1 0.0 1.5 1 1 1 2 2 2 1 DDE superfamily endonuclease Adeno_IVa2 PF02456.15 KII72060.1 - 0.12 11.1 0.2 0.16 10.7 0.2 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein DUF4371 PF14291.6 KII72061.1 - 0.019 14.6 0.3 0.023 14.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) VCBS PF13517.6 KII72062.1 - 1.2e-06 29.0 0.8 3e-06 27.7 0.2 1.9 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII72062.1 - 0.00017 21.6 1.5 0.47 10.6 0.0 2.4 2 0 0 2 2 2 2 FG-GAP repeat DUF4261 PF14080.6 KII72065.1 - 0.13 12.4 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) Sortilin_C PF15901.5 KII72066.1 - 2.8e-06 27.8 0.3 3.8e-06 27.4 0.3 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72066.1 - 0.058 12.2 0.1 0.08 11.7 0.1 1.2 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, DDE_3 PF13358.6 KII72067.1 - 0.0025 17.6 0.0 0.0046 16.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Ldl_recept_a PF00057.18 KII72070.1 - 0.00015 21.9 24.0 0.00063 19.9 20.3 2.6 1 1 1 2 2 2 2 Low-density lipoprotein receptor domain class A DSHCT PF08148.12 KII72072.1 - 3.1e-27 95.2 0.1 3.6e-27 95.0 0.1 1.0 1 0 0 1 1 1 1 DSHCT (NUC185) domain OCRE PF17780.1 KII72073.1 - 9.4e-17 60.8 11.1 1.9e-16 59.8 11.1 1.6 1 0 0 1 1 1 1 OCRE domain RRM_1 PF00076.22 KII72073.1 - 4.3e-05 23.3 0.0 0.00016 21.4 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 KII72074.1 - 2.5e-05 24.1 10.6 0.00014 21.8 2.9 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 KII72074.1 - 0.00078 19.2 11.3 0.0044 16.8 3.5 2.3 2 0 0 2 2 2 2 Zinc knuckle RNA_lig_T4_1 PF09511.10 KII72074.1 - 0.049 13.5 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA ligase zf-CCHC_4 PF14392.6 KII72074.1 - 0.14 12.0 9.5 0.89 9.3 1.4 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 KII72074.1 - 0.22 11.3 11.5 0.26 11.1 1.1 2.3 2 0 0 2 2 2 0 C2H2 zinc-finger zf-CCHC_5 PF14787.6 KII72074.1 - 1.3 8.8 10.2 0.23 11.2 3.1 2.3 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-met PF12874.7 KII72075.1 - 0.003 17.9 0.2 0.011 16.1 0.2 2.0 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KII72075.1 - 0.0033 17.1 0.2 0.0067 16.2 0.2 1.6 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KII72075.1 - 0.0048 17.1 0.2 0.0048 17.1 0.2 2.4 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KII72075.1 - 0.021 15.6 0.3 0.064 14.1 0.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KII72075.1 - 0.041 14.2 0.6 0.041 14.2 0.6 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) OTT_1508_deam PF14441.6 KII72075.1 - 0.051 13.6 0.3 0.12 12.4 0.3 1.8 1 1 1 2 2 2 0 OTT_1508-like deaminase zf-C2H2 PF00096.26 KII72075.1 - 0.12 12.9 0.4 0.31 11.6 0.4 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF2358 PF10184.9 KII72076.1 - 0.0017 18.6 1.4 0.0021 18.3 1.4 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) Pentaxin PF00354.17 KII72076.1 - 0.023 14.4 0.6 0.027 14.2 0.6 1.2 1 0 0 1 1 1 0 Pentaxin family Mhr1 PF12829.7 KII72076.1 - 0.028 14.5 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination YhdB PF14148.6 KII72079.1 - 0.091 12.9 0.3 0.34 11.0 0.0 2.1 2 0 0 2 2 2 0 YhdB-like protein Guanylate_cyc PF00211.20 KII72080.1 - 3.5e-53 179.9 0.6 5.4e-53 179.3 0.6 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 KII72080.1 - 4.3e-17 62.3 0.3 6.4e-17 61.7 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KII72080.1 - 2.5e-16 59.8 1.0 4.5e-16 59.0 1.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 KII72080.1 - 0.011 15.1 0.5 0.02 14.3 0.5 1.4 1 0 0 1 1 1 0 Heme NO binding associated DUF2897 PF11446.8 KII72081.1 - 0.028 14.3 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) HTH_6 PF01418.17 KII72081.1 - 0.095 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family FYVE_2 PF02318.16 KII72081.1 - 0.11 12.8 10.5 0.14 12.4 10.5 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger DUF4637 PF15470.6 KII72081.1 - 1.8 8.2 6.7 2.7 7.7 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) zf-B_box PF00643.24 KII72081.1 - 9.1 6.5 13.7 26 5.1 13.7 1.8 1 0 0 1 1 1 0 B-box zinc finger DnaB_2 PF07261.11 KII72083.1 - 0.0036 17.0 0.2 0.029 14.1 0.1 2.0 2 0 0 2 2 2 1 Replication initiation and membrane attachment DUF3128 PF11326.8 KII72083.1 - 0.068 13.5 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3128) DnaB_2 PF07261.11 KII72084.1 - 0.11 12.2 0.1 0.27 11.0 0.1 1.6 2 0 0 2 2 2 0 Replication initiation and membrane attachment SNAP PF14938.6 KII72087.1 - 0.00026 20.5 0.9 0.00036 20.1 0.9 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII72087.1 - 0.024 14.9 0.1 0.07 13.4 0.1 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat Cas_Cas02710 PF09670.10 KII72087.1 - 0.037 12.8 0.6 0.22 10.3 0.1 2.0 1 1 0 2 2 2 0 CRISPR-associated protein (Cas_Cas02710) NSF PF02071.20 KII72087.1 - 0.047 14.4 4.8 11 7.3 0.1 4.1 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat UvrA_inter PF17760.1 KII72087.1 - 0.095 12.8 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 UvrA interaction domain MIT PF04212.18 KII72087.1 - 0.12 12.5 5.0 3.3 7.8 0.7 3.5 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain SNAP PF14938.6 KII72088.1 - 1.1e-10 41.5 2.6 1.3e-10 41.2 2.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 KII72088.1 - 0.0052 17.3 0.4 1.3 9.6 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat PaREP1 PF05942.11 KII72088.1 - 0.06 13.3 0.5 0.27 11.2 0.3 2.1 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family DUF4373 PF14297.6 KII72088.1 - 0.062 14.1 1.0 0.11 13.3 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4373) TPR_11 PF13414.6 KII72088.1 - 0.077 12.7 8.9 4.3 7.1 0.0 3.9 3 1 1 4 4 4 0 TPR repeat PPR PF01535.20 KII72088.1 - 0.11 12.8 0.1 1.3 9.4 0.0 2.6 2 0 0 2 2 2 0 PPR repeat TPR_1 PF00515.28 KII72088.1 - 0.41 10.5 11.7 5.7 6.9 1.7 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat NSF PF02071.20 KII72088.1 - 0.59 11.1 10.2 3 9.0 0.2 3.7 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.6 KII72088.1 - 2.8 8.4 8.2 14 6.2 0.0 4.2 2 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII72088.1 - 3.3 8.1 11.3 5.5 7.4 2.1 4.2 3 1 2 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 KII72088.1 - 5.3 7.2 7.3 2.5 8.3 2.2 2.6 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain DDE_1 PF03184.19 KII72091.1 - 9.3e-14 51.5 0.2 3e-06 27.0 0.1 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease HECT PF00632.25 KII72093.1 - 0.082 12.4 0.1 0.094 12.2 0.1 1.2 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) Malt_amylase_C PF16657.5 KII72094.1 - 0.094 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain tRNA_lig_CPD PF08302.11 KII72095.1 - 0.013 14.9 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain SNAP PF14938.6 KII72096.1 - 1.2e-09 38.1 1.3 1.3e-09 37.9 1.3 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP T4SS-DNA_transf PF02534.14 KII72096.1 - 0.0008 18.3 0.9 0.0012 17.8 0.9 1.2 1 0 0 1 1 1 1 Type IV secretory system Conjugative DNA transfer TPR_1 PF00515.28 KII72096.1 - 0.0044 16.8 8.1 0.52 10.2 1.2 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat MAS20 PF02064.15 KII72096.1 - 0.0046 17.1 0.2 0.96 9.6 0.0 2.2 2 0 0 2 2 2 2 MAS20 protein import receptor TraG-D_C PF12696.7 KII72096.1 - 0.092 12.7 0.6 0.25 11.3 0.3 1.8 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG TPR_8 PF13181.6 KII72096.1 - 1.7 9.0 4.6 21 5.7 0.4 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 KII72096.1 - 6.7 8.0 6.4 1.4e+02 4.0 0.0 4.7 4 1 1 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat CENP-Q PF13094.6 KII72101.1 - 0.048 13.9 12.5 0.44 10.7 0.5 3.2 2 2 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1722 PF08349.11 KII72101.1 - 0.075 13.3 3.8 0.17 12.1 0.6 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1722) Citrate_ly_lig PF08218.11 KII72101.1 - 0.25 11.0 5.8 2.4 7.8 0.1 3.2 2 1 1 3 3 3 0 Citrate lyase ligase C-terminal domain SlyX PF04102.12 KII72101.1 - 0.59 10.8 5.8 4.2 8.0 0.2 3.9 4 0 0 4 4 4 0 SlyX KxDL PF10241.9 KII72101.1 - 1.3 9.4 16.5 6.3 7.2 2.9 4.4 4 1 0 4 4 4 0 Uncharacterized conserved protein GrpE PF01025.19 KII72101.1 - 4.7 6.8 11.7 3.9 7.1 2.7 2.7 1 1 1 2 2 2 0 GrpE Kinesin PF00225.23 KII72102.1 - 2.2e-52 178.1 0.3 2.2e-52 178.1 0.3 1.8 2 0 0 2 2 2 1 Kinesin motor domain YkyA PF10368.9 KII72102.1 - 0.059 13.0 8.6 0.1 12.3 8.6 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein CREPT PF16566.5 KII72102.1 - 0.069 13.3 5.7 0.078 13.2 0.4 2.3 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour UPF0184 PF03670.13 KII72102.1 - 0.22 12.0 2.5 3.8 8.0 0.8 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) DUF2508 PF10704.9 KII72102.1 - 0.5 10.6 3.3 0.44 10.7 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) ABC2_membrane PF01061.24 KII72103.1 - 2e-45 154.8 31.7 2.9e-45 154.3 31.7 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 KII72103.1 - 6.1e-20 72.1 1.3 6.1e-20 72.1 0.1 1.6 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 KII72103.1 - 2e-07 30.5 31.1 4.5e-07 29.3 31.1 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 KII72103.1 - 0.0011 18.3 9.6 0.0011 18.3 9.6 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 KII72103.1 - 0.0017 18.3 0.0 2.1 8.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KII72103.1 - 0.025 14.5 0.3 0.049 13.5 0.3 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 KII72103.1 - 0.072 13.4 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 KII72103.1 - 0.085 12.9 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF1440 PF07274.12 KII72103.1 - 0.12 12.8 5.3 0.43 10.9 1.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1440) Triabin PF03973.13 KII72103.1 - 0.13 12.1 0.8 0.26 11.2 0.8 1.4 1 0 0 1 1 1 0 Triabin AAA_16 PF13191.6 KII72103.1 - 0.15 12.4 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain tRNA-synt_2c PF01411.19 KII72104.1 - 2.2e-201 670.2 0.0 2.9e-201 669.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 KII72104.1 - 6.4e-14 51.8 1.3 1.4e-13 50.7 1.3 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF455 PF04305.14 KII72104.1 - 0.078 12.5 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF455) zf-piccolo PF05715.13 KII72104.1 - 0.45 10.7 4.6 6.6 7.0 3.1 2.5 2 0 0 2 2 2 0 Piccolo Zn-finger Methyltransf_28 PF02636.17 KII72105.1 - 0.018 14.7 1.0 0.064 12.9 0.6 1.9 1 1 1 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase FBD PF08387.10 KII72105.1 - 0.073 13.0 0.4 0.18 11.7 0.4 1.7 1 0 0 1 1 1 0 FBD DUF725 PF05267.12 KII72105.1 - 0.38 10.7 3.0 0.29 11.1 0.5 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF725) Flavokinase PF01687.17 KII72106.1 - 3.8e-20 72.2 0.0 4.2e-20 72.1 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase DUF373 PF04123.13 KII72107.1 - 0.00094 18.7 5.2 0.0013 18.3 5.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF373) SUR7 PF06687.12 KII72107.1 - 6.5 6.3 24.7 1.9 8.0 6.7 2.2 1 1 1 2 2 2 0 SUR7/PalI family Nup54 PF13874.6 KII72108.1 - 0.018 15.2 0.1 0.022 14.9 0.1 1.4 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DUF758 PF05527.11 KII72108.1 - 0.021 14.8 0.1 0.82 9.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF758) RBD-FIP PF09457.10 KII72108.1 - 0.043 13.7 1.6 0.1 12.6 0.2 2.1 2 0 0 2 2 2 0 FIP domain COG5 PF10392.9 KII72108.1 - 0.043 14.0 0.1 0.17 12.0 0.1 1.8 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Iso_dh PF00180.20 KII72109.1 - 1.4e-68 231.6 0.0 1.7e-68 231.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PHD PF00628.29 KII72112.1 - 0.0043 16.9 5.2 0.0092 15.8 5.2 1.5 1 0 0 1 1 1 1 PHD-finger LRR_6 PF13516.6 KII72113.1 - 0.006 16.5 13.3 0.93 9.7 0.0 5.7 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 KII72113.1 - 0.027 14.9 34.8 0.22 12.0 0.2 7.9 5 1 3 9 9 9 0 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KII72113.1 - 0.12 11.9 3.6 1.8 8.0 0.5 3.3 2 1 1 3 3 3 0 Leucine-rich repeat Creatinase_N_2 PF16189.5 KII72114.1 - 7.6e-42 143.1 0.1 1.4e-41 142.3 0.1 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 KII72114.1 - 1.9e-40 138.8 0.0 2.6e-40 138.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 KII72114.1 - 3.1e-19 68.8 0.4 1e-18 67.2 0.4 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 KII72114.1 - 0.0019 18.9 0.0 0.43 11.2 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain RT_RNaseH_2 PF17919.1 KII72115.1 - 3.2e-09 36.7 0.1 6e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII72116.1 - 4.3e-19 68.9 0.0 5.8e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72116.1 - 1.8e-18 66.4 0.2 3.2e-18 65.6 0.2 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII72116.1 - 0.0051 16.6 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII72116.1 - 0.021 15.0 0.0 0.043 14.0 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger Poxvirus PF06227.12 KII72117.1 - 0.084 12.6 1.0 0.12 12.2 1.0 1.2 1 0 0 1 1 1 0 dsDNA Poxvirus CRM1_C PF08767.11 KII72118.1 - 5.4e-80 268.9 11.6 5.4e-80 268.9 11.6 3.0 3 0 0 3 3 3 2 CRM1 C terminal Xpo1 PF08389.12 KII72118.1 - 1.3e-24 87.0 6.0 1.3e-24 87.0 6.0 3.8 3 1 0 3 3 3 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 KII72118.1 - 1e-22 79.5 0.1 2.8e-22 78.1 0.1 1.8 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 KII72118.1 - 1.4e-19 69.9 0.5 1.4e-19 69.9 0.5 3.1 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 IBN_N PF03810.19 KII72118.1 - 5e-13 48.8 2.0 2.6e-12 46.5 0.2 3.0 3 0 0 3 3 3 1 Importin-beta N-terminal domain CRM1_repeat PF18777.1 KII72118.1 - 8.7e-09 34.7 1.3 1.6e-08 33.9 0.2 2.1 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat DUF1133 PF06576.11 KII72118.1 - 0.14 11.6 0.0 0.43 9.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) DDE_3 PF13358.6 KII72119.1 - 7.5e-07 29.0 0.2 3.9e-06 26.7 0.2 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease GTP_EFTU PF00009.27 KII72121.1 - 3.7e-43 147.3 0.1 3.7e-43 147.3 0.1 1.8 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KII72121.1 - 6.2e-25 87.7 0.8 2.4e-24 85.8 0.5 2.2 2 1 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KII72121.1 - 1.1e-13 51.4 0.9 2.8e-13 50.0 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KII72121.1 - 0.0013 18.8 0.2 0.017 15.2 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 KII72121.1 - 7.5 6.5 7.2 0.39 10.7 0.6 2.3 3 0 0 3 3 3 0 Elongation factor Tu domain 4 Oxysterol_BP PF01237.18 KII72123.1 - 3.7e-16 58.9 0.3 5.1e-16 58.5 0.3 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein Oxysterol_BP PF01237.18 KII72124.1 - 6.6e-26 91.0 4.9 2.2e-25 89.3 4.9 1.8 1 1 0 1 1 1 1 Oxysterol-binding protein DUF2897 PF11446.8 KII72125.1 - 0.11 12.4 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) HEAT_2 PF13646.6 KII72127.1 - 3.9e-07 30.4 0.0 0.2 12.1 0.0 3.6 1 1 4 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 KII72127.1 - 5.6e-07 29.9 0.0 0.11 13.1 0.0 4.1 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 KII72127.1 - 1.9e-06 27.6 0.8 0.56 10.6 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.23 KII72127.1 - 0.0014 18.6 0.0 2 8.6 0.0 3.0 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 KII72127.1 - 0.002 16.7 0.1 0.0029 16.3 0.1 1.2 1 0 0 1 1 1 1 Adaptin N terminal region NUC173 PF08161.12 KII72127.1 - 0.0028 17.3 0.0 0.032 13.9 0.0 2.6 3 0 0 3 3 3 1 NUC173 domain CLASP_N PF12348.8 KII72127.1 - 0.017 14.7 0.1 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 CLASP N terminal Flavi_propep PF01570.17 KII72127.1 - 0.054 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Flavivirus polyprotein propeptide DNA_pol_phi PF04931.13 KII72127.1 - 0.27 9.3 0.0 0.35 8.9 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi FCH PF00611.23 KII72129.1 - 0.039 14.2 1.3 1.1 9.6 0.0 2.9 2 1 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain VAD1-2 PF15310.6 KII72129.1 - 0.061 13.2 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling DUF1041 PF06292.17 KII72129.1 - 0.083 13.3 0.3 0.3 11.5 0.0 2.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1041) YgaB PF14182.6 KII72129.1 - 0.1 13.0 1.2 16 6.0 0.0 3.0 2 1 1 3 3 3 0 YgaB-like protein Stn1_C PF12659.7 KII72129.1 - 0.19 11.7 1.6 1.2 9.1 0.1 2.8 3 0 0 3 3 3 0 Telomere capping C-terminal wHTH Cortex-I_coil PF09304.10 KII72130.1 - 0.014 15.6 0.8 0.014 15.6 0.8 2.8 1 1 1 3 3 3 0 Cortexillin I, coiled coil Cytochrom_B562 PF07361.11 KII72130.1 - 0.051 14.2 5.0 0.64 10.7 0.6 3.0 2 1 1 3 3 3 0 Cytochrome b562 DEAD PF00270.29 KII72134.1 - 2.8e-40 137.9 0.1 5.2e-40 137.1 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII72134.1 - 1.6e-28 99.2 0.3 4.9e-27 94.5 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII72134.1 - 1.9e-06 28.0 0.0 3.4e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KII72134.1 - 0.00012 21.6 0.1 0.00021 20.7 0.1 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit SURF4 PF02077.15 KII72135.1 - 5.9e-85 285.1 8.8 6.7e-85 284.9 8.8 1.0 1 0 0 1 1 1 1 SURF4 family CEBP_ZZ PF16366.5 KII72137.1 - 3.8e-23 81.5 11.5 5.3e-23 81.0 11.5 1.2 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 KII72137.1 - 0.0018 18.1 0.0 0.0025 17.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VWC PF00093.18 KII72137.1 - 0.012 15.9 4.9 0.018 15.4 4.9 1.3 1 0 0 1 1 1 0 von Willebrand factor type C domain zf-B_box PF00643.24 KII72137.1 - 0.37 11.0 9.8 0.71 10.1 9.8 1.4 1 0 0 1 1 1 0 B-box zinc finger DcpS_C PF11969.8 KII72138.1 - 3.7e-27 95.0 0.2 4.2e-27 94.9 0.2 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 KII72138.1 - 3e-26 92.0 0.2 3.7e-26 91.7 0.2 1.1 1 0 0 1 1 1 1 HIT domain DDE_1 PF03184.19 KII72139.1 - 1.1e-06 28.4 0.0 2.2e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.7 KII72140.1 - 1.9e-12 47.4 0.8 3.8e-12 46.5 0.4 1.7 1 1 1 2 2 2 1 ISXO2-like transposase domain Acetyltransf_19 PF18015.1 KII72140.1 - 0.06 13.6 0.1 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Ribonuclease_3 PF00636.26 KII72141.1 - 8e-39 132.5 0.0 9.7e-23 80.8 0.0 3.0 3 0 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 KII72141.1 - 4e-22 78.8 2.5 4.7e-09 36.5 0.2 4.7 5 0 0 5 5 5 2 Ribonuclease-III-like Dicer_dimer PF03368.14 KII72141.1 - 8.2e-17 61.2 0.0 2.7e-16 59.5 0.0 2.0 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 KII72141.1 - 1.3e-11 44.9 0.5 5.5e-11 42.8 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KII72141.1 - 3.9e-11 43.0 0.0 1.3e-10 41.3 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.26 KII72141.1 - 2.1e-10 41.1 1.2 7e-05 23.5 0.1 3.7 3 0 0 3 3 3 3 Double-stranded RNA binding motif ResIII PF04851.15 KII72141.1 - 4.6e-10 39.8 0.0 1.9e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PAZ PF02170.22 KII72141.1 - 9.2 6.1 7.2 1.4 8.7 0.0 3.3 5 0 0 5 5 5 0 PAZ domain DDE_Tnp_IS1595 PF12762.7 KII72142.1 - 1.9e-09 37.7 0.1 2.6e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF4943 PF16301.5 KII72142.1 - 0.067 13.2 0.1 0.095 12.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4943) Response_reg PF00072.24 KII72143.1 - 2.6e-27 95.2 0.0 4.2e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 KII72143.1 - 8.3e-25 86.7 0.1 2e-24 85.5 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal RB_A PF01858.17 KII72145.1 - 0.0033 17.3 0.1 0.0045 16.8 0.1 1.3 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain MarR PF01047.22 KII72147.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 MarR family zf-UBR PF02207.20 KII72153.1 - 4.2e-13 49.3 17.1 4.2e-13 49.3 17.1 2.7 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 KII72153.1 - 0.0031 17.3 0.0 0.007 16.1 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS RVT_1 PF00078.27 KII72154.1 - 7.6e-26 91.0 0.0 2.3e-25 89.4 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72154.1 - 3.6e-19 69.1 0.0 1e-18 67.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII72154.1 - 0.00045 19.9 0.4 0.0023 17.7 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain RVP PF00077.20 KII72154.1 - 0.0033 17.7 0.2 0.027 14.8 0.0 2.5 2 1 0 2 2 2 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII72154.1 - 0.0033 17.2 0.7 0.0072 16.1 0.7 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII72154.1 - 0.011 16.3 0.0 0.027 15.0 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII72154.1 - 0.049 14.3 0.0 0.1 13.2 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease zf-UBR PF02207.20 KII72155.1 - 7.8e-10 38.8 21.1 7.8e-10 38.8 21.1 2.3 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) EGF PF00008.27 KII72163.1 - 0.0058 16.9 4.1 0.0058 16.9 4.1 2.8 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 KII72163.1 - 1.1 9.7 20.3 0.11 12.9 4.9 2.8 3 0 0 3 3 3 0 EGF-like domain EGF_3 PF12947.7 KII72163.1 - 1.1 9.5 18.9 0.12 12.6 5.2 2.7 2 0 0 2 2 2 0 EGF domain Laminin_EGF PF00053.24 KII72163.1 - 1.7 8.9 16.7 1.2 9.4 3.2 2.5 2 0 0 2 2 2 0 Laminin EGF domain Disintegrin PF00200.23 KII72165.1 - 1.5e-10 41.7 12.1 2.6e-10 41.0 12.1 1.4 1 0 0 1 1 1 1 Disintegrin Reprolysin PF01421.19 KII72165.1 - 0.0012 18.8 0.0 0.0042 17.0 0.0 1.9 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_4 PF13583.6 KII72165.1 - 0.011 15.4 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like BppL_N PF18338.1 KII72165.1 - 0.067 13.0 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 0 Lower baseplate protein N-terminal domain RRM_1 PF00076.22 KII72167.1 - 0.022 14.6 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4283 PF14111.6 KII72167.1 - 0.072 12.6 0.0 0.083 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) C1_1 PF00130.22 KII72168.1 - 0.0081 16.0 0.9 0.0097 15.8 0.2 1.5 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_7 PF02591.15 KII72168.1 - 0.023 14.9 0.1 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 C4-type zinc ribbon domain RuvA_N PF01330.21 KII72168.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.5 1 1 0 1 1 1 0 RuvA N terminal domain Vfa1 PF08432.10 KII72169.1 - 0.03 14.6 9.2 0.037 14.4 9.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Podoplanin PF05808.11 KII72169.1 - 0.078 13.1 5.2 0.095 12.8 5.2 1.1 1 0 0 1 1 1 0 Podoplanin RR_TM4-6 PF06459.12 KII72169.1 - 0.26 11.1 6.6 0.28 11.0 6.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 KII72169.1 - 0.43 9.3 3.6 0.5 9.1 3.6 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 KII72169.1 - 0.45 8.8 4.6 0.43 8.8 4.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Rrp15p PF07890.12 KII72170.1 - 2.6e-08 34.3 2.0 3.4e-08 33.9 2.0 1.4 1 1 0 1 1 1 1 Rrp15p OAD_gamma PF04277.13 KII72170.1 - 0.65 10.6 2.1 0.56 10.8 0.4 1.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Bcl-2 PF00452.19 KII72171.1 - 0.015 15.9 0.3 0.55 10.9 0.2 3.4 1 1 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family FBA PF04300.13 KII72171.1 - 0.048 13.3 0.1 0.088 12.5 0.1 1.3 1 0 0 1 1 1 0 F-box associated region zf-C2H2_8 PF15909.5 KII72171.1 - 0.42 10.9 1.6 0.49 10.7 0.1 1.8 2 0 0 2 2 2 0 C2H2-type zinc ribbon RT_RNaseH_2 PF17919.1 KII72172.1 - 6.3e-32 109.6 0.0 1.5e-31 108.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72172.1 - 3.1e-29 101.3 0.0 6.1e-29 100.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72172.1 - 5.8e-27 94.6 0.0 9.6e-27 93.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72172.1 - 2.3e-20 73.0 0.0 6.4e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72172.1 - 7.6e-14 51.6 0.3 2.1e-13 50.1 0.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII72172.1 - 0.00062 19.5 0.0 0.0017 18.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII72172.1 - 0.047 14.0 0.0 0.16 12.3 0.0 1.9 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII72172.1 - 0.061 13.9 0.0 0.24 12.0 0.0 2.0 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease TSNR_N PF04705.12 KII72173.1 - 0.0066 16.5 0.2 0.022 14.9 0.1 1.8 1 1 0 2 2 2 1 Thiostrepton-resistance methylase, N terminus Peptidase_C39 PF03412.15 KII72173.1 - 0.013 15.3 0.2 0.022 14.6 0.2 1.4 1 1 0 1 1 1 0 Peptidase C39 family YvrJ PF12841.7 KII72174.1 - 0.029 13.9 0.2 0.051 13.1 0.2 1.3 1 0 0 1 1 1 0 YvrJ protein family DHR-2 PF06920.13 KII72175.1 - 1.4e-08 33.9 1.4 5.6e-06 25.3 0.0 2.0 2 0 0 2 2 2 2 Dock homology region 2 DUF4083 PF13314.6 KII72176.1 - 0.14 12.1 2.1 0.22 11.5 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) TMEM156 PF15106.6 KII72176.1 - 0.18 11.2 0.8 0.24 10.8 0.8 1.2 1 0 0 1 1 1 0 TMEM156 protein family DUF5383 PF17355.2 KII72176.1 - 0.24 11.8 0.8 0.36 11.2 0.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5383) Serpin PF00079.20 KII72178.1 - 8.8e-21 74.6 0.1 1.3e-15 57.6 0.0 2.1 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) CDC45 PF02724.14 KII72178.1 - 0.016 13.5 10.6 0.018 13.4 10.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 KII72178.1 - 0.39 8.8 1.1 0.44 8.6 1.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 KII72178.1 - 0.41 9.4 3.3 0.54 9.0 3.3 1.2 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 KII72178.1 - 3.6 5.7 23.2 4.5 5.4 23.2 1.1 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 KII72178.1 - 5.4 6.1 5.5 6.6 5.8 5.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Merozoite_SPAM PF07133.11 KII72178.1 - 9.9 6.1 34.3 19 5.2 34.3 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Zip PF02535.22 KII72180.1 - 1.8 7.7 2.7 1.9 7.6 2.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4781 PF16013.5 KII72183.1 - 0.042 12.7 0.2 0.045 12.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF2788 PF10981.8 KII72183.1 - 0.072 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2788) SMI1_KNR4 PF09346.10 KII72183.1 - 0.12 12.8 0.0 0.15 12.4 0.0 1.1 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) HTH_Tnp_Tc3_2 PF01498.18 KII72188.1 - 0.014 15.6 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 Transposase Stap_Strp_tox_C PF02876.17 KII72191.1 - 0.06 13.7 0.1 0.084 13.2 0.1 1.3 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain RVT_1 PF00078.27 KII72192.1 - 2.4e-06 27.3 0.0 4.3e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peripla_BP_5 PF13433.6 KII72193.1 - 0.085 11.8 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein domain RVT_1 PF00078.27 KII72194.1 - 8.1e-12 45.1 0.1 1.7e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72194.1 - 0.014 15.6 0.0 0.054 13.7 0.0 2.0 2 0 0 2 2 2 0 Integrase core domain DDE_3 PF13358.6 KII72195.1 - 0.00021 21.1 0.3 0.0004 20.2 0.2 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease SIN1_PH PF16979.5 KII72196.1 - 9.2e-10 38.8 4.4 1e-09 38.6 4.4 1.0 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology Mannosyl_trans PF05007.13 KII72197.1 - 0.0031 17.4 0.1 0.0034 17.3 0.1 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) MULE PF10551.9 KII72198.1 - 1.6e-13 50.9 0.0 3.8e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain zf-CDGSH PF09360.10 KII72202.1 - 4.4e-10 39.6 0.4 7.5e-10 38.9 0.4 1.5 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type NUDIX PF00293.28 KII72203.1 - 2.8e-09 37.1 0.0 3.2e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain DUF1173 PF06666.11 KII72203.1 - 0.14 11.1 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1173) Las1 PF04031.13 KII72205.1 - 2.8e-11 43.8 1.0 3.7e-11 43.4 0.3 1.6 2 0 0 2 2 2 1 Las1-like GDE_N PF12439.8 KII72205.1 - 0.0051 16.3 0.0 0.007 15.8 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme N terminal zf-RING_5 PF14634.6 KII72206.1 - 3.5e-07 30.1 8.8 6.7e-07 29.2 8.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KII72206.1 - 3.8e-07 29.9 11.9 7.5e-07 28.9 11.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KII72206.1 - 9.4e-07 28.8 13.4 1.8e-06 27.8 13.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KII72206.1 - 2.6e-06 27.7 13.5 4.9e-06 26.8 13.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KII72206.1 - 3e-06 27.0 11.7 3.4e-06 26.8 10.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KII72206.1 - 4.5e-06 26.4 14.0 1.3e-05 24.9 14.0 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KII72206.1 - 0.00035 20.4 10.9 0.00085 19.1 10.9 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KII72206.1 - 0.0023 18.0 13.0 0.0047 17.1 13.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RVT PF13966.6 KII72206.1 - 0.13 13.0 2.6 0.46 11.2 2.5 2.1 1 1 0 1 1 1 0 zinc-binding in reverse transcriptase zf-RING_11 PF17123.5 KII72206.1 - 0.84 9.4 10.8 2.5 7.9 10.8 1.9 1 0 0 1 1 1 0 RING-like zinc finger Uso1_p115_head PF04869.14 KII72207.1 - 4.7e-12 45.7 6.1 8.2e-12 44.9 6.1 1.3 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region DUF3585 PF12130.8 KII72207.1 - 0.00094 19.3 1.4 0.0041 17.3 2.2 1.7 2 0 0 2 2 1 1 Bivalent Mical/EHBP Rab binding domain APG6_N PF17675.1 KII72207.1 - 0.0017 18.9 2.1 0.0028 18.2 2.1 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 KII72207.1 - 0.0044 17.0 4.4 0.0064 16.5 2.5 1.9 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 KII72207.1 - 0.0046 17.0 0.6 0.0046 17.0 0.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) DHR10 PF18595.1 KII72207.1 - 0.0057 16.7 2.3 0.014 15.4 2.3 1.7 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain PTRF_SDPR PF15237.6 KII72207.1 - 0.008 15.8 0.8 0.013 15.2 0.8 1.2 1 0 0 1 1 1 1 PTRF/SDPR family ATG16 PF08614.11 KII72207.1 - 0.011 15.9 5.0 0.021 15.0 5.0 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Prefoldin_2 PF01920.20 KII72207.1 - 0.031 14.2 1.8 0.088 12.8 1.8 1.8 1 0 0 1 1 1 0 Prefoldin subunit SHE3 PF17078.5 KII72207.1 - 0.035 13.8 10.4 0.44 10.2 6.8 2.5 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF730 PF05325.11 KII72207.1 - 0.038 14.0 0.1 0.081 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF730) DUF4472 PF14739.6 KII72207.1 - 0.048 14.4 4.6 0.16 12.7 2.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) GAS PF13851.6 KII72207.1 - 0.051 12.9 6.3 0.15 11.4 6.3 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Vac_Fusion PF02346.16 KII72207.1 - 0.057 13.1 4.3 0.56 9.9 0.5 3.5 3 1 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Fez1 PF06818.15 KII72207.1 - 0.057 13.9 3.5 0.094 13.2 3.5 1.2 1 0 0 1 1 1 0 Fez1 Med14 PF08638.11 KII72207.1 - 0.06 12.8 1.0 0.13 11.7 0.9 1.5 1 1 0 1 1 1 0 Mediator complex subunit MED14 JIP_LZII PF16471.5 KII72207.1 - 0.095 12.9 2.8 0.51 10.6 0.8 2.5 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II UCR_hinge PF02320.16 KII72207.1 - 0.11 12.7 0.4 0.25 11.6 0.4 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein YabA PF06156.13 KII72207.1 - 0.12 13.1 4.9 0.63 10.7 4.9 2.3 1 1 0 1 1 1 0 Initiation control protein YabA HrpB7 PF09486.10 KII72207.1 - 0.12 12.8 0.5 0.2 12.0 0.5 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Cep57_MT_bd PF06657.13 KII72207.1 - 0.12 12.9 6.1 2.6 8.6 2.2 3.4 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 AAA_23 PF13476.6 KII72207.1 - 0.14 12.7 0.8 0.23 11.9 0.8 1.4 1 0 0 1 1 1 0 AAA domain Nsp1_C PF05064.13 KII72207.1 - 0.2 11.5 3.0 0.15 11.8 1.2 1.7 2 0 0 2 2 1 0 Nsp1-like C-terminal region DivIC PF04977.15 KII72207.1 - 0.2 11.5 4.3 0.46 10.3 1.3 2.8 2 1 1 3 3 2 0 Septum formation initiator Jnk-SapK_ap_N PF09744.9 KII72207.1 - 0.2 11.8 6.5 0.13 12.5 3.4 2.1 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 TMF_TATA_bd PF12325.8 KII72207.1 - 0.24 11.6 4.1 0.6 10.3 1.7 2.4 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding BRE1 PF08647.11 KII72207.1 - 0.26 11.4 6.6 3.2 7.9 1.7 2.9 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Plk4_PB2 PF18409.1 KII72207.1 - 0.26 12.0 1.2 1 10.0 0.7 2.3 2 1 0 2 2 1 0 Polo-like Kinase 4 Polo Box 2 DIMCO_N PF16844.5 KII72207.1 - 0.32 11.4 2.1 0.42 11.0 0.1 2.0 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal TolA_bind_tri PF16331.5 KII72207.1 - 0.73 9.9 4.7 0.42 10.7 2.3 1.8 2 0 0 2 2 1 0 TolA binding protein trimerisation UPF0242 PF06785.11 KII72207.1 - 0.81 9.8 9.2 0.36 10.9 5.8 2.1 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CC2-LZ PF16516.5 KII72207.1 - 2.3 8.6 6.4 2.3 8.6 3.6 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Cep57_CLD_2 PF14197.6 KII72207.1 - 2.6 8.2 11.1 0.28 11.3 4.0 2.7 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Syntaxin_2 PF14523.6 KII72207.1 - 3.6 8.0 9.1 0.21 12.0 2.4 2.4 3 0 0 3 3 2 0 Syntaxin-like protein ZapB PF06005.12 KII72207.1 - 6.8 7.2 8.3 28 5.3 4.6 3.0 2 1 0 2 2 1 0 Cell division protein ZapB DDE_Tnp_IS1595 PF12762.7 KII72209.1 - 2.8e-15 56.7 0.0 2.9e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain RT_RNaseH_2 PF17919.1 KII72210.1 - 1.6e-35 121.1 0.0 3.2e-35 120.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72210.1 - 1.7e-31 108.6 0.0 4.5e-31 107.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72210.1 - 2.6e-27 95.8 0.0 4.4e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP_2 PF08284.11 KII72210.1 - 2.2e-06 27.5 0.4 4.4e-06 26.5 0.4 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 KII72210.1 - 3.9e-05 23.9 0.0 9.7e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII72210.1 - 0.00022 21.7 0.0 0.00051 20.5 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII72210.1 - 0.016 15.0 0.0 0.04 13.7 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease Asp_protease_2 PF13650.6 KII72210.1 - 0.066 13.9 0.0 0.19 12.4 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease Tnp_22_trimer PF17489.2 KII72210.1 - 0.15 12.0 0.9 0.44 10.6 0.0 2.2 2 0 0 2 2 2 0 L1 transposable element trimerization domain rve PF00665.26 KII72212.1 - 3.6e-13 49.7 0.0 7.7e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII72212.1 - 0.019 15.2 0.1 0.077 13.2 0.0 2.0 1 1 1 2 2 2 0 DDE domain Sgf11_N PF18519.1 KII72212.1 - 0.1 12.2 0.2 0.3 10.7 0.1 1.8 2 0 0 2 2 2 0 SAGA-associated factor 11 N-terminal domain RPN5_C PF18098.1 KII72213.1 - 0.093 12.8 0.4 0.16 12.1 0.4 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN5 C-terminal domain rve PF00665.26 KII72216.1 - 2.1e-13 50.5 0.0 4.4e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Sgf11_N PF18519.1 KII72216.1 - 0.099 12.2 0.2 0.3 10.7 0.1 1.8 2 0 0 2 2 2 0 SAGA-associated factor 11 N-terminal domain gag-asp_proteas PF13975.6 KII72219.1 - 4.3e-07 30.4 0.1 1e-06 29.2 0.1 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII72219.1 - 0.001 18.9 0.3 0.0023 17.7 0.3 1.6 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.6 KII72219.1 - 0.0069 17.0 0.0 0.017 15.7 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII72219.1 - 0.071 13.4 0.0 0.19 12.0 0.0 1.8 1 1 0 1 1 1 0 Retroviral aspartyl protease Kelch_4 PF13418.6 KII72225.1 - 2.1e-06 27.6 1.9 0.0021 18.0 0.4 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII72225.1 - 0.00026 20.5 0.9 0.51 10.0 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 KII72225.1 - 0.014 15.6 0.6 4.4 7.8 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Myb_DNA-binding PF00249.31 KII72229.1 - 1.1e-07 31.9 1.7 6.2e-06 26.3 0.5 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain HTH_Tnp_1_2 PF13022.6 KII72229.1 - 0.033 14.4 0.1 0.096 12.8 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase Myb_DNA-bind_6 PF13921.6 KII72229.1 - 0.035 14.4 3.7 0.065 13.5 0.6 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain MerR-DNA-bind PF09278.11 KII72229.1 - 0.11 13.1 0.2 4.4 7.9 0.0 3.0 4 0 0 4 4 4 0 MerR, DNA binding HJURP_mid PF12346.8 KII72230.1 - 0.07 13.6 1.3 0.16 12.5 1.3 1.6 1 1 0 1 1 1 0 Holliday junction recognition protein-associated repeat NOA36 PF06524.12 KII72230.1 - 0.11 11.8 1.9 0.14 11.5 1.9 1.1 1 0 0 1 1 1 0 NOA36 protein MULE PF10551.9 KII72232.1 - 0.00092 19.6 0.1 0.0023 18.3 0.1 1.7 2 0 0 2 2 2 1 MULE transposase domain Sortilin-Vps10 PF15902.5 KII72235.1 - 1.6e-07 30.5 0.0 2.2e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72235.1 - 0.0067 16.2 0.4 2.9 8.3 0.0 3.8 3 1 0 3 3 3 1 BNR/Asp-box repeat BslA PF17735.1 KII72236.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Biofilm surface layer A CBS PF00571.28 KII72237.1 - 5e-13 49.3 2.2 3.3e-08 33.8 0.2 2.3 2 0 0 2 2 2 2 CBS domain Nrf1_DNA-bind PF10491.9 KII72237.1 - 0.045 13.4 0.1 0.057 13.1 0.1 1.2 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 DUF21 PF01595.20 KII72238.1 - 1.4e-29 103.0 2.0 1.8e-29 102.7 2.0 1.1 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain Toxin_GhoT_OrtT PF10753.9 KII72238.1 - 3.2 8.1 11.4 0.11 12.8 2.7 2.7 3 1 0 3 3 3 0 Toxin GhoT_OrtT DAGK_cat PF00781.24 KII72239.1 - 0.00049 19.7 0.3 0.0026 17.4 0.3 2.1 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain BCAS3 PF12490.8 KII72239.1 - 0.11 12.0 0.8 0.15 11.5 0.8 1.2 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 RecR PF02132.15 KII72239.1 - 0.45 10.1 6.6 7.2 6.3 2.1 2.8 2 0 0 2 2 2 0 RecR protein C1_1 PF00130.22 KII72239.1 - 0.58 10.1 5.4 0.58 10.1 2.1 2.5 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DAGK_acc PF00609.19 KII72240.1 - 9.5e-46 156.0 0.0 1.5e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DUF3384 PF11864.8 KII72240.1 - 0.046 12.6 0.3 0.066 12.1 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) PMI_typeI PF01238.21 KII72241.1 - 8.5e-79 265.4 1.3 8.2e-77 258.9 1.3 2.2 1 1 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 KII72241.1 - 0.0048 16.6 0.0 0.81 9.4 0.0 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_1 PF00190.22 KII72241.1 - 0.042 13.4 0.1 3.9 7.1 0.0 2.4 2 0 0 2 2 2 0 Cupin DAGK_acc PF00609.19 KII72242.1 - 2.3e-43 148.3 0.0 4.5e-43 147.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KII72242.1 - 4.6e-17 61.8 0.0 9.9e-17 60.7 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 KII72242.1 - 0.0046 16.8 6.0 0.014 15.2 6.0 2.0 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 KII72242.1 - 2.9 7.8 7.4 0.43 10.5 2.9 2.0 2 0 0 2 2 2 0 PHD-finger FLYWCH PF04500.16 KII72244.1 - 2.6e-14 53.1 10.2 5.5e-14 52.0 10.2 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 KII72244.1 - 7.3e-08 32.7 0.2 1.6e-07 31.6 0.2 1.6 1 0 0 1 1 1 1 MULE transposase domain UPF0223 PF05256.12 KII72244.1 - 0.13 12.6 0.8 3 8.2 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0223) YEATS PF03366.16 KII72246.1 - 6.9e-29 99.7 0.7 1.1e-28 99.0 0.7 1.3 1 0 0 1 1 1 1 YEATS family G-patch_2 PF12656.7 KII72252.1 - 1.5e-16 60.2 0.0 3.5e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 KII72252.1 - 4e-09 36.2 0.1 8.1e-09 35.2 0.1 1.5 1 0 0 1 1 1 1 G-patch domain KOW PF00467.29 KII72252.1 - 6e-07 29.2 3.6 0.018 15.0 0.6 3.5 3 0 0 3 3 3 2 KOW motif KN17_SH3 PF18131.1 KII72252.1 - 5.7e-05 23.1 2.4 0.00032 20.7 0.3 2.5 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain DUF5608 PF18356.1 KII72252.1 - 0.077 13.0 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5608) Glyco_hydro_31 PF01055.26 KII72254.1 - 4.2e-78 263.5 0.5 5.1e-78 263.2 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 KII72254.1 - 1.4e-07 31.6 0.1 3.1e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Gal_mutarotas_2 PF13802.6 KII72255.1 - 8.4e-20 70.9 0.2 1.9e-19 69.7 0.2 1.6 1 0 0 1 1 1 1 Galactose mutarotase-like Glyco_hydro_31 PF01055.26 KII72255.1 - 3e-19 69.5 0.0 5.1e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 UAA PF08449.11 KII72256.1 - 5.3e-56 190.0 20.8 5.3e-56 190.0 20.8 2.0 1 1 1 2 2 2 2 UAA transporter family EamA PF00892.20 KII72256.1 - 2.9e-10 40.5 27.6 2e-05 24.8 0.3 3.6 3 1 0 3 3 3 2 EamA-like transporter family Piwi PF02171.17 KII72260.1 - 3.1e-63 213.8 4.0 6.7e-63 212.7 4.0 1.5 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 KII72260.1 - 2e-08 34.1 3.9 2.6e-08 33.8 1.5 2.4 2 0 0 2 2 2 1 PAZ domain DUF2703 PF10865.8 KII72260.1 - 0.0058 16.8 0.1 0.84 9.8 0.0 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF2703) ArgoN PF16486.5 KII72260.1 - 0.038 14.6 1.7 0.081 13.5 0.3 2.3 2 0 0 2 2 2 0 N-terminal domain of argonaute RVT_1 PF00078.27 KII72265.1 - 1.9e-09 37.4 0.0 2.1e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2HE PF16278.5 KII72266.1 - 0.079 13.4 7.7 0.59 10.6 7.7 2.1 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger rve PF00665.26 KII72268.1 - 6.7e-19 68.2 0.0 1.1e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII72268.1 - 0.05 13.4 0.0 0.14 11.9 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain RVT_1 PF00078.27 KII72271.1 - 7.5e-09 35.4 0.3 1e-08 35.0 0.3 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sas10_Utp3 PF04000.15 KII72271.1 - 0.11 13.2 0.1 0.35 11.5 0.1 1.8 1 1 1 2 2 2 0 Sas10/Utp3/C1D family Apo-VLDL-II PF05418.11 KII72273.1 - 0.11 13.0 0.0 0.18 12.4 0.0 1.3 1 0 0 1 1 1 0 Apovitellenin I (Apo-VLDL-II) RVT_1 PF00078.27 KII72274.1 - 7.2e-24 84.5 0.1 2e-23 83.1 0.1 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TarS_C1 PF18674.1 KII72275.1 - 0.02 14.8 0.2 0.039 13.9 0.2 1.4 1 0 0 1 1 1 0 TarS beta-glycosyltransferase C-terminal domain 1 RVT_1 PF00078.27 KII72277.1 - 8.1e-05 22.2 0.0 0.00012 21.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NYD-SP12_N PF15015.6 KII72277.1 - 0.03 12.7 0.0 0.038 12.4 0.0 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal Kelch_6 PF13964.6 KII72278.1 - 1.9e-25 88.2 18.5 5.4e-06 26.5 0.2 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII72278.1 - 2.9e-18 65.6 20.8 2.7e-05 24.1 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KII72278.1 - 8.3e-15 54.1 18.3 7.5e-06 25.4 0.1 6.0 6 1 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KII72278.1 - 1.9e-14 53.5 17.0 0.0041 17.4 0.1 6.2 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KII72278.1 - 1.8e-11 43.5 12.8 0.0011 18.9 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 KII72278.1 - 3e-11 43.0 13.8 0.0036 17.2 0.2 5.3 5 0 0 5 5 5 4 Kelch motif rve PF00665.26 KII72279.1 - 2.6e-09 37.3 0.0 6.6e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Serpin PF00079.20 KII72283.1 - 8.1e-70 236.0 2.7 9.1e-70 235.8 2.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII72284.1 - 3.2e-55 188.0 0.0 3.5e-55 187.8 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF5571 PF17732.1 KII72284.1 - 0.094 12.1 0.3 0.14 11.6 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5571) Serpin PF00079.20 KII72286.1 - 2.1e-30 106.3 0.1 2.5e-30 106.1 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) PAP2 PF01569.21 KII72288.1 - 6.8e-15 55.0 2.6 1.1e-14 54.4 2.6 1.2 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 KII72288.1 - 0.0067 16.9 2.6 0.0067 16.9 2.6 2.2 2 1 0 2 2 2 1 PAP2 superfamily C-terminal PAP2_3 PF14378.6 KII72288.1 - 0.0088 15.7 4.5 0.026 14.2 4.5 1.8 1 1 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 KII72288.1 - 0.19 11.9 1.7 7 6.8 0.1 2.3 1 1 1 2 2 2 0 Divergent PAP2 family Mago_nashi PF02792.14 KII72289.1 - 1e-44 152.1 0.2 1.1e-44 152.0 0.2 1.0 1 0 0 1 1 1 1 Mago nashi protein Pkinase PF00069.25 KII72291.1 - 3.9e-57 193.6 0.0 8.2e-57 192.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII72291.1 - 1.8e-33 115.9 0.0 3.7e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII72291.1 - 1.6e-06 27.7 0.7 7e-05 22.3 0.0 2.7 3 0 0 3 3 3 1 Kinase-like HR1 PF02185.16 KII72291.1 - 0.024 14.7 15.7 0.033 14.3 5.0 2.9 3 0 0 3 3 3 0 Hr1 repeat Med9 PF07544.13 KII72291.1 - 0.12 12.5 2.9 0.26 11.4 0.1 2.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Retrotrans_gag PF03732.17 KII72292.1 - 0.0004 20.6 0.0 0.001 19.3 0.0 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.23 KII72292.1 - 0.0065 16.5 3.4 0.0065 16.5 3.4 2.7 2 0 0 2 2 2 1 Zinc knuckle Retrotran_gag_2 PF14223.6 KII72292.1 - 0.018 14.7 0.0 2 8.1 0.0 2.3 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type zf-CCHC_5 PF14787.6 KII72292.1 - 0.26 11.0 8.2 1.7 8.4 1.3 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 KII72292.1 - 0.77 9.6 12.8 0.61 10.0 2.7 2.9 2 1 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII72292.1 - 0.93 9.3 4.4 0.48 10.2 1.4 2.2 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 KII72292.1 - 1.4 8.8 7.6 0.13 12.1 2.2 2.0 2 0 0 2 2 2 0 Zinc knuckle Aldo_ket_red PF00248.21 KII72293.1 - 4.1e-07 29.5 0.0 4.5e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII72294.1 - 3.1e-14 52.8 0.0 3.8e-14 52.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RHH_8 PF17723.1 KII72294.1 - 0.19 11.9 0.0 0.26 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribbon-Helix-Helix transcriptional regulator family Serpin PF00079.20 KII72295.1 - 4e-49 167.9 1.0 4.4e-49 167.8 1.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII72296.1 - 1.4e-42 146.3 4.0 1.6e-42 146.2 4.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3788 PF12663.7 KII72296.1 - 0.085 12.8 0.2 0.37 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3788) PYC_OADA PF02436.18 KII72297.1 - 2.2e-34 119.0 0.0 3.6e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_lipoyl PF00364.22 KII72297.1 - 1.4e-16 60.0 1.0 3e-16 59.0 1.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KII72297.1 - 1.7e-11 43.7 1.6 2.7e-07 30.3 0.1 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_D23 PF16576.5 KII72297.1 - 3.9e-07 29.5 0.2 0.00063 19.0 0.0 2.2 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 KII72297.1 - 0.00068 20.3 0.5 1.8 9.3 0.1 2.4 2 0 0 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 KII72297.1 - 0.02 14.8 0.2 0.049 13.5 0.1 1.6 1 1 0 1 1 1 0 Glycine cleavage H-protein PASTA PF03793.19 KII72297.1 - 0.085 12.7 0.1 0.26 11.2 0.1 1.8 2 0 0 2 2 2 0 PASTA domain 4HBT_2 PF13279.6 KII72299.1 - 6e-05 23.5 0.0 6.4e-05 23.4 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily TraI_2 PF07514.11 KII72300.1 - 2.7e-33 115.3 0.0 4.4e-33 114.6 0.0 1.3 1 0 0 1 1 1 1 Putative helicase TraI_2_C PF07515.11 KII72300.1 - 2e-11 43.9 0.0 4.5e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Putative conjugal transfer nickase/helicase TraI C-term UvrD_C PF13361.6 KII72301.1 - 3.4e-12 46.4 0.0 5.1e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 KII72301.1 - 1.3e-11 44.1 0.1 7.8e-11 41.6 0.1 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 KII72301.1 - 6.4e-09 35.8 0.4 1.8e-08 34.3 0.0 1.7 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 KII72301.1 - 2.5e-07 30.7 0.0 0.02 14.6 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 KII72301.1 - 1.4e-05 25.5 0.0 4e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain Cupin_8 PF13621.6 KII72302.1 - 1.3e-16 61.1 0.7 3.9e-16 59.5 0.7 1.7 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KII72302.1 - 3.2e-07 30.1 0.1 7.3e-07 29.0 0.1 1.6 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 KII72302.1 - 0.046 14.1 0.1 0.42 11.0 0.0 2.4 1 1 0 2 2 2 0 JmjC domain, hydroxylase HTH_47 PF16221.5 KII72302.1 - 0.063 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 winged helix-turn-helix GRDP-like PF07173.12 KII72303.1 - 2.9e-05 24.7 0.4 3.9e-05 24.3 0.4 1.3 1 0 0 1 1 1 1 Glycine-rich domain-containing protein-like YukC PF10140.9 KII72304.1 - 0.017 13.9 1.7 0.019 13.8 0.2 1.7 1 1 1 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC Aldo_ket_red PF00248.21 KII72305.1 - 3e-16 59.5 0.0 3.2e-16 59.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII72307.1 - 1.3e-27 96.7 0.1 3.1e-27 95.5 0.1 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII72308.1 - 3.2e-39 134.9 0.0 3.8e-39 134.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII72309.1 - 6.9e-15 55.0 0.0 1.2e-14 54.2 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII72310.1 - 8.4e-52 176.2 0.1 1.7e-51 175.2 0.1 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family DUF1543 PF07566.12 KII72313.1 - 0.14 11.9 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1543) Kinesin PF00225.23 KII72315.1 - 5.9e-106 354.2 2.2 5.9e-106 354.2 2.2 2.2 2 0 0 2 2 1 1 Kinesin motor domain Microtub_bd PF16796.5 KII72315.1 - 2.7e-50 170.2 0.0 2.7e-50 170.2 0.0 2.8 2 1 0 2 2 1 1 Microtubule binding CENP-F_leu_zip PF10473.9 KII72315.1 - 1.7e-11 44.3 57.7 1e-05 25.6 22.2 5.5 2 2 3 5 5 5 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 KII72315.1 - 2.2e-10 40.7 45.7 0.025 14.7 1.1 6.1 3 1 2 5 5 5 4 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 KII72315.1 - 1.7e-09 38.2 51.1 0.0019 18.5 8.0 4.9 2 2 3 5 5 5 4 Autophagy protein 16 (ATG16) GAS PF13851.6 KII72315.1 - 7.3e-07 28.7 59.6 5.5e-05 22.6 17.1 5.4 1 1 4 5 5 5 2 Growth-arrest specific micro-tubule binding Filament PF00038.21 KII72315.1 - 8.2e-06 25.6 48.0 0.00039 20.1 10.6 4.8 1 1 3 4 4 4 2 Intermediate filament protein OmpH PF03938.14 KII72315.1 - 4.1e-05 23.9 37.3 0.017 15.5 3.3 4.7 1 1 3 4 4 4 2 Outer membrane protein (OmpH-like) Fez1 PF06818.15 KII72315.1 - 4.5e-05 24.0 15.1 4.5e-05 24.0 15.1 4.7 1 1 3 4 4 4 1 Fez1 Mod_r PF07200.13 KII72315.1 - 4.9e-05 23.5 56.7 0.12 12.5 0.7 6.1 1 1 4 5 5 5 2 Modifier of rudimentary (Mod(r)) protein HAP1_N PF04849.13 KII72315.1 - 0.00011 21.6 18.8 0.00011 21.6 18.8 3.5 2 1 1 3 3 3 1 HAP1 N-terminal conserved region Laminin_I PF06008.14 KII72315.1 - 0.00016 21.5 40.3 0.022 14.5 13.4 4.3 1 1 3 4 4 4 2 Laminin Domain I ADIP PF11559.8 KII72315.1 - 0.00017 21.7 57.9 0.0055 16.8 2.6 6.0 3 2 2 6 6 6 3 Afadin- and alpha -actinin-Binding CEP63 PF17045.5 KII72315.1 - 0.00091 19.2 4.2 0.00091 19.2 4.2 4.3 1 1 2 4 4 4 2 Centrosomal protein of 63 kDa UPF0242 PF06785.11 KII72315.1 - 0.0016 18.6 12.2 0.0016 18.6 12.2 4.9 2 1 2 4 4 2 1 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 KII72315.1 - 0.0016 17.8 30.0 0.15 11.4 16.5 3.6 1 1 2 3 3 3 2 Domain of unknown function (DUF4407) MAD PF05557.13 KII72315.1 - 0.0023 16.4 54.9 0.0063 15.0 17.3 2.9 1 1 2 3 3 3 2 Mitotic checkpoint protein APG6_N PF17675.1 KII72315.1 - 0.0025 18.4 59.8 0.13 12.8 6.8 5.3 1 1 4 5 5 5 3 Apg6 coiled-coil region EzrA PF06160.12 KII72315.1 - 0.0026 16.0 56.5 0.011 14.0 18.9 4.5 1 1 4 5 5 5 3 Septation ring formation regulator, EzrA FlaC_arch PF05377.11 KII72315.1 - 0.0029 18.0 40.6 0.047 14.1 3.3 8.4 4 3 3 8 8 7 1 Flagella accessory protein C (FlaC) CALCOCO1 PF07888.11 KII72315.1 - 0.0029 16.5 23.5 0.0029 16.5 23.5 3.0 1 1 2 3 3 3 2 Calcium binding and coiled-coil domain (CALCOCO1) like DivIC PF04977.15 KII72315.1 - 0.003 17.3 37.7 0.27 11.0 2.5 7.5 5 1 1 7 7 7 2 Septum formation initiator Tho2 PF11262.8 KII72315.1 - 0.0059 15.8 7.5 0.0059 15.8 7.5 4.0 1 1 2 4 4 3 1 Transcription factor/nuclear export subunit protein 2 ERM PF00769.19 KII72315.1 - 0.0061 16.4 21.6 0.0061 16.4 21.6 4.6 2 1 4 6 6 6 3 Ezrin/radixin/moesin family DUF4201 PF13870.6 KII72315.1 - 0.007 16.1 14.6 0.007 16.1 14.6 5.1 2 2 3 5 5 5 1 Domain of unknown function (DUF4201) Uso1_p115_C PF04871.13 KII72315.1 - 0.01 16.2 11.6 0.01 16.2 11.6 5.3 1 1 4 5 5 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region ZapB PF06005.12 KII72315.1 - 0.011 16.2 46.0 0.88 10.1 0.2 6.8 3 1 3 6 6 6 0 Cell division protein ZapB Syntaxin-6_N PF09177.11 KII72315.1 - 0.014 15.9 5.9 0.014 15.9 5.9 5.7 2 1 3 5 5 5 0 Syntaxin 6, N-terminal DUF1664 PF07889.12 KII72315.1 - 0.018 15.0 36.2 0.12 12.5 7.1 6.0 1 1 4 6 6 6 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 KII72315.1 - 0.024 14.8 56.5 0.036 14.3 11.6 5.2 1 1 4 5 5 5 0 JNK_SAPK-associated protein-1 Spc7 PF08317.11 KII72315.1 - 0.027 13.4 54.2 0.0068 15.3 25.8 4.0 1 1 3 4 4 4 0 Spc7 kinetochore protein Lebercilin PF15619.6 KII72315.1 - 0.033 13.8 57.2 2.1 8.0 2.6 5.6 1 1 4 5 5 5 0 Ciliary protein causing Leber congenital amaurosis disease Striatin PF08232.12 KII72315.1 - 0.04 14.5 0.2 0.04 14.5 0.2 4.7 3 2 1 4 4 2 0 Striatin family FPP PF05911.11 KII72315.1 - 0.052 11.7 65.3 0.0036 15.6 29.1 3.8 2 1 2 4 4 4 0 Filament-like plant protein, long coiled-coil TMF_TATA_bd PF12325.8 KII72315.1 - 0.072 13.3 53.5 0.028 14.7 10.8 6.3 2 2 3 6 6 6 0 TATA element modulatory factor 1 TATA binding YabA PF06156.13 KII72315.1 - 0.09 13.4 53.0 5.2 7.8 1.8 8.7 5 2 3 8 8 8 0 Initiation control protein YabA DUF3584 PF12128.8 KII72315.1 - 0.15 9.6 42.8 0.048 11.2 28.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) HAUS-augmin3 PF14932.6 KII72315.1 - 0.15 11.6 49.1 0.035 13.7 11.4 4.6 3 2 2 5 5 4 0 HAUS augmin-like complex subunit 3 DUF948 PF06103.11 KII72315.1 - 0.28 11.4 15.5 0.16 12.2 3.4 4.8 2 2 4 6 6 6 0 Bacterial protein of unknown function (DUF948) KASH_CCD PF14662.6 KII72315.1 - 0.31 10.9 56.7 0.046 13.5 17.8 4.7 1 1 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH Myosin_tail_1 PF01576.19 KII72315.1 - 0.37 8.5 56.9 0.053 11.3 37.3 3.0 2 1 1 3 3 3 0 Myosin tail MscS_porin PF12795.7 KII72315.1 - 0.4 10.2 35.2 0.56 9.7 20.0 3.7 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain Tropomyosin_1 PF12718.7 KII72315.1 - 0.43 10.7 55.3 0.16 12.1 22.0 5.3 1 1 3 5 5 5 0 Tropomyosin like SHE3 PF17078.5 KII72315.1 - 0.48 10.1 71.3 0.066 12.9 11.1 5.4 2 1 0 4 4 4 0 SWI5-dependent HO expression protein 3 HrpB7 PF09486.10 KII72315.1 - 0.71 10.2 13.4 0.15 12.4 4.1 3.3 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) MbeD_MobD PF04899.12 KII72315.1 - 0.8 9.9 13.6 11 6.2 0.7 5.2 3 2 2 5 5 5 0 MbeD/MobD like DUF3734 PF12536.8 KII72315.1 - 0.91 9.9 10.2 0.92 9.9 2.7 3.5 2 1 1 3 3 3 0 Patatin phospholipase IFT57 PF10498.9 KII72315.1 - 0.96 8.4 56.1 0.097 11.6 11.0 5.4 2 1 5 7 7 7 0 Intra-flagellar transport protein 57 Laminin_II PF06009.12 KII72315.1 - 1.2 9.2 41.2 0.38 10.8 9.3 6.4 2 1 5 7 7 7 0 Laminin Domain II Tropomyosin PF00261.20 KII72315.1 - 1.2 8.4 42.9 0.09 12.1 23.1 4.0 2 2 0 2 2 2 0 Tropomyosin CCDC144C PF14915.6 KII72315.1 - 2.4 7.2 57.1 0.17 10.9 39.9 3.3 1 1 2 3 3 2 0 CCDC144C protein coiled-coil region T3SSipB PF16535.5 KII72315.1 - 2.7 8.4 28.4 0.064 13.7 4.7 4.8 2 1 1 4 4 3 0 Type III cell invasion protein SipB ApoO PF09769.9 KII72315.1 - 3.1 7.8 9.9 1.9 8.5 0.8 3.8 4 0 0 4 4 3 0 Apolipoprotein O MCC-bdg_PDZ PF10506.9 KII72315.1 - 3.3 7.8 27.6 0.28 11.2 0.5 5.2 5 1 0 5 5 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TACC_C PF05010.14 KII72315.1 - 3.6 7.3 51.2 1.6 8.5 18.1 4.6 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal WXG100 PF06013.12 KII72315.1 - 4.2 7.7 13.1 2.4 8.4 1.3 4.9 3 1 0 4 4 3 0 Proteins of 100 residues with WXG DUF2968 PF11180.8 KII72315.1 - 5.6 6.6 23.4 0.36 10.4 4.9 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2968) HMMR_N PF15905.5 KII72315.1 - 5.9 6.3 56.3 0.3 10.5 25.5 4.2 1 1 3 4 4 3 0 Hyaluronan mediated motility receptor N-terminal Fib_alpha PF08702.10 KII72315.1 - 7.7 6.7 53.6 0.19 11.9 15.5 5.1 2 1 4 6 6 5 0 Fibrinogen alpha/beta chain family BRE1 PF08647.11 KII72315.1 - 8.1 6.6 59.5 0.06 13.4 7.2 6.3 3 1 3 6 6 6 0 BRE1 E3 ubiquitin ligase Rootletin PF15035.6 KII72315.1 - 9.4 6.2 54.2 0.84 9.6 12.4 4.4 1 1 2 3 3 2 0 Ciliary rootlet component, centrosome cohesion Seryl_tRNA_N PF02403.22 KII72315.1 - 9.6 6.5 49.2 0.19 12.0 6.6 6.5 3 2 3 7 7 6 0 Seryl-tRNA synthetase N-terminal domain PCI PF01399.27 KII72317.1 - 8e-05 23.1 0.1 0.00023 21.7 0.1 1.8 1 1 0 1 1 1 1 PCI domain DUF4359 PF14271.6 KII72317.1 - 0.052 14.3 0.4 10 6.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4359) HSF_DNA-bind PF00447.17 KII72318.1 - 0.044 14.4 0.4 0.064 13.9 0.4 1.3 1 1 0 1 1 1 0 HSF-type DNA-binding Kinetochor_Ybp2 PF08568.10 KII72318.1 - 0.068 11.6 0.1 0.071 11.6 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family, YAP/Alf4/glomulin zf-LITAF-like PF10601.9 KII72319.1 - 3.9 7.8 10.9 0.84 9.9 0.1 3.2 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain TMEM223 PF14640.6 KII72319.1 - 4 7.6 8.5 0.5 10.5 3.5 1.9 2 1 0 2 2 2 0 Transmembrane protein 223 EMP24_GP25L PF01105.24 KII72321.1 - 2.7e-23 82.9 2.0 2.9e-23 82.7 2.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2569 PF10754.9 KII72321.1 - 0.034 14.6 0.2 0.042 14.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Ada_Zn_binding PF02805.16 KII72322.1 - 0.025 14.6 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Metal binding domain of Ada CEP76-C2 PF15627.6 KII72324.1 - 0.13 11.8 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 CEP76 C2 domain Tom6 PF17112.5 KII72324.1 - 0.14 11.7 0.7 5.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal MRAP PF15183.6 KII72325.1 - 0.038 13.9 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family zf-C2H2 PF00096.26 KII72326.1 - 1.9e-09 37.4 14.4 9e-05 22.7 0.2 4.0 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII72326.1 - 1.9e-07 31.3 16.6 0.00067 20.3 0.3 4.2 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KII72326.1 - 1.2e-06 28.4 8.1 0.00011 22.1 0.6 3.1 3 0 0 3 3 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KII72326.1 - 7.9e-06 26.1 21.5 0.00026 21.3 0.5 5.2 5 0 0 5 5 5 2 Zinc-finger double domain zf_C2H2_ZHX PF18387.1 KII72326.1 - 0.0001 21.8 5.7 0.11 12.2 0.4 3.1 2 1 1 3 3 3 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_jaz PF12171.8 KII72326.1 - 0.00027 21.1 7.7 0.0031 17.8 0.1 3.7 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding ARS2 PF04959.13 KII72326.1 - 0.00072 20.0 2.7 0.12 12.7 0.0 2.2 1 1 1 2 2 2 2 Arsenite-resistance protein 2 zf-met PF12874.7 KII72326.1 - 0.0013 19.0 7.5 0.077 13.4 0.1 3.7 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-Di19 PF05605.12 KII72326.1 - 0.0018 18.6 3.0 1.2 9.4 0.0 2.8 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 KII72326.1 - 0.035 13.7 0.7 1.3 8.7 0.0 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger ROS_MUCR PF05443.11 KII72326.1 - 0.073 13.1 3.0 0.12 12.4 0.3 2.3 1 1 1 2 2 2 0 ROS/MUCR transcriptional regulator protein zf-C2H2_2 PF12756.7 KII72326.1 - 0.084 13.2 8.6 5.3 7.4 8.7 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF2180 PF09947.9 KII72326.1 - 0.27 11.2 3.5 1.1 9.3 3.5 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) CTU2 PF10288.9 KII72326.1 - 0.6 10.4 5.7 0.28 11.4 3.2 1.8 1 1 1 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-MYST PF17772.1 KII72326.1 - 0.72 9.5 7.8 2.8 7.6 0.3 3.4 2 1 1 3 3 3 0 MYST family zinc finger domain DUF2197 PF09963.9 KII72326.1 - 1.9 8.8 7.4 11 6.4 0.0 3.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) DDE_3 PF13358.6 KII72328.1 - 0.00032 20.5 0.0 0.0006 19.6 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease Pep3_Vps18 PF05131.14 KII72329.1 - 4.9e-13 49.2 0.8 1.3e-12 47.7 0.3 2.1 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 KII72329.1 - 1.4e-05 25.0 7.7 0.018 14.9 0.2 3.9 3 1 1 4 4 4 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 KII72329.1 - 0.00022 21.0 3.0 0.00072 19.3 3.0 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KII72329.1 - 0.0034 17.0 1.2 0.008 15.8 1.2 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.9 KII72329.1 - 0.0053 17.2 0.3 0.018 15.5 0.1 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-C3HC4 PF00097.25 KII72329.1 - 0.031 14.2 1.3 0.1 12.5 1.3 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KII72329.1 - 0.031 14.6 2.2 0.11 12.9 2.2 2.0 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 KII72329.1 - 0.054 13.5 2.9 0.16 12.0 2.9 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 KII72329.1 - 0.083 12.9 6.2 0.068 13.1 2.5 2.5 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 KII72329.1 - 0.13 12.1 4.0 0.39 10.5 4.0 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-C3H2C3 PF17122.5 KII72329.1 - 0.2 11.7 6.0 0.078 13.0 2.5 2.2 2 0 0 2 2 2 0 Zinc-finger DDE_3 PF13358.6 KII72330.1 - 2.3e-07 30.7 0.0 2.8e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease GST_C_3 PF14497.6 KII72331.1 - 1.3e-06 28.5 0.0 3e-06 27.4 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KII72331.1 - 3.5e-06 27.4 0.0 6.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KII72331.1 - 0.00034 20.9 0.0 0.00095 19.4 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KII72331.1 - 0.0039 17.2 0.0 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KII72331.1 - 0.0041 17.4 0.1 0.011 16.1 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 KII72331.1 - 0.04 14.7 0.0 0.063 14.0 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 KII72331.1 - 0.12 12.2 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sec63 PF02889.16 KII72332.1 - 5.4e-120 399.4 8.3 6.4e-65 218.9 0.9 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 KII72332.1 - 9.7e-51 172.0 1.7 3.9e-25 88.6 0.3 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 KII72332.1 - 6.9e-28 97.8 4.5 1.9e-13 50.8 0.1 2.9 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KII72332.1 - 4.7e-18 65.6 6.7 1.7e-08 34.7 0.3 4.1 3 1 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 KII72332.1 - 3.7e-09 37.0 2.1 0.001 19.4 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KII72332.1 - 1.4e-07 32.0 1.1 0.0093 16.3 0.2 2.8 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 KII72332.1 - 1.1e-05 25.2 0.0 0.11 12.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KII72332.1 - 0.00021 21.7 0.4 0.41 11.1 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 KII72332.1 - 0.0007 19.4 0.2 1 9.1 0.0 3.6 4 0 0 4 4 4 1 IstB-like ATP binding protein TniB PF05621.11 KII72332.1 - 0.00081 18.9 0.7 1.7 8.0 0.0 3.6 4 0 0 4 4 4 1 Bacterial TniB protein T2SSE PF00437.20 KII72332.1 - 0.002 17.2 0.0 0.16 11.0 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein PhoH PF02562.16 KII72332.1 - 0.0021 17.5 0.0 1.3 8.4 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_7 PF12775.7 KII72332.1 - 0.031 13.8 0.0 2.3 7.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 KII72332.1 - 0.033 13.8 0.0 0.39 10.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 KII72332.1 - 0.31 10.5 3.4 4.6 6.7 0.0 2.8 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Serpin PF00079.20 KII72336.1 - 5.6e-38 131.2 7.1 6.6e-38 131.0 7.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Kelch_6 PF13964.6 KII72337.1 - 9.7e-15 54.3 4.2 0.00033 20.8 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII72337.1 - 9.9e-14 51.2 0.7 0.00045 20.4 0.2 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII72337.1 - 1e-12 47.9 1.3 0.00018 21.4 0.3 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII72337.1 - 3.2e-12 45.8 5.5 0.00049 19.6 0.3 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KII72337.1 - 1.6e-06 27.9 2.3 0.18 11.8 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII72337.1 - 9.5e-06 25.5 3.4 1.9 8.5 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII72338.1 - 7.8e-08 31.8 0.5 0.0028 17.2 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII72338.1 - 0.0004 20.6 1.9 1.1 9.6 0.1 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KII72338.1 - 0.00055 20.1 3.0 1.3 9.4 0.1 3.3 2 1 1 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII72338.1 - 0.00093 19.1 2.6 0.48 10.5 0.1 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII72338.1 - 0.0019 18.2 3.5 0.35 10.9 0.3 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 KII72338.1 - 0.027 14.5 1.6 1.5 8.9 0.2 2.7 2 0 0 2 2 2 0 Kelch motif Clathrin-link PF09268.10 KII72338.1 - 0.42 10.0 1.4 0.5 9.8 0.2 1.8 2 0 0 2 2 2 0 Clathrin, heavy-chain linker Kelch_4 PF13418.6 KII72339.1 - 0.00021 21.2 0.5 0.0024 17.8 0.1 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 KII72339.1 - 0.00034 20.8 0.3 0.4 11.0 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII72339.1 - 0.0029 17.5 0.9 0.059 13.4 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 KII72339.1 - 0.052 13.6 0.3 1.9 8.5 0.1 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 KII72339.1 - 0.085 12.5 1.5 9.9 5.8 0.1 2.3 2 0 0 2 2 2 0 Kelch motif FISNA PF14484.6 KII72340.1 - 0.044 14.0 0.0 0.14 12.4 0.0 1.7 2 0 0 2 2 2 0 Fish-specific NACHT associated domain Ldl_recept_a PF00057.18 KII72341.1 - 2.1e-05 24.6 19.5 5e-05 23.4 6.7 2.7 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Sigma_reg_N PF13800.6 KII72341.1 - 0.053 13.8 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Sortilin-Vps10 PF15902.5 KII72341.1 - 0.053 12.3 0.8 0.079 11.7 0.0 1.7 2 0 0 2 2 2 0 Sortilin, neurotensin receptor 3, NPV_P10 PF05531.12 KII72342.1 - 0.00035 21.0 10.5 0.18 12.3 0.2 2.3 1 1 1 2 2 2 2 Nucleopolyhedrovirus P10 protein E2R135 PF11570.8 KII72342.1 - 0.00048 20.4 2.4 0.00071 19.9 2.4 1.3 1 0 0 1 1 1 1 Coiled-coil receptor-binding R-domain of colicin E2 Chordopox_A30L PF06015.12 KII72342.1 - 0.00074 19.3 4.8 0.028 14.2 4.0 2.6 1 1 1 2 2 2 1 Chordopoxvirus A30L protein IFT46_B_C PF12317.8 KII72342.1 - 0.0016 18.2 3.8 0.002 17.9 3.6 1.3 1 1 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal Laminin_II PF06009.12 KII72342.1 - 0.0028 17.7 8.4 0.015 15.3 2.4 2.2 1 1 1 2 2 2 1 Laminin Domain II DUF1664 PF07889.12 KII72342.1 - 0.006 16.6 9.2 0.03 14.4 2.1 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) YscO PF07321.12 KII72342.1 - 0.013 15.5 1.4 0.025 14.6 0.1 1.8 1 1 1 2 2 2 0 Type III secretion protein YscO SlyX PF04102.12 KII72342.1 - 0.014 16.0 5.7 0.66 10.6 0.9 2.7 2 2 0 2 2 2 0 SlyX Cep57_MT_bd PF06657.13 KII72342.1 - 0.017 15.6 3.3 0.1 13.1 0.3 2.6 1 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 PTPA PF03095.15 KII72342.1 - 0.031 13.7 1.0 0.039 13.4 1.0 1.1 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein HsbA PF12296.8 KII72342.1 - 0.032 14.6 2.8 0.11 13.0 1.1 2.1 2 0 0 2 2 2 0 Hydrophobic surface binding protein A Corona_S2 PF01601.16 KII72342.1 - 0.034 12.7 2.3 0.048 12.1 2.3 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DHR10 PF18595.1 KII72342.1 - 0.04 14.0 9.7 1.2 9.2 0.8 2.1 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain MscS_porin PF12795.7 KII72342.1 - 0.047 13.2 0.6 0.047 13.2 0.6 2.1 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain Vir_act_alpha_C PF10400.9 KII72342.1 - 0.06 14.0 0.7 5.7 7.7 0.0 2.6 1 1 0 2 2 2 0 Virulence activator alpha C-term DUF948 PF06103.11 KII72342.1 - 0.074 13.3 7.5 2.1 8.7 2.4 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) V-SNARE PF05008.15 KII72342.1 - 0.084 13.3 7.3 1.3 9.4 1.5 3.0 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Spc7 PF08317.11 KII72342.1 - 0.14 11.0 12.9 0.3 9.9 12.9 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Laminin_I PF06008.14 KII72342.1 - 0.17 11.6 11.9 1.4 8.6 11.9 2.3 1 1 0 1 1 1 0 Laminin Domain I DUF16 PF01519.16 KII72342.1 - 0.17 12.4 12.4 0.19 12.2 2.5 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF4140 PF13600.6 KII72342.1 - 0.17 12.3 4.7 2.8 8.4 1.3 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Nsp1_C PF05064.13 KII72342.1 - 0.18 11.6 8.5 0.89 9.4 2.0 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region TMF_TATA_bd PF12325.8 KII72342.1 - 0.21 11.8 8.7 1.1 9.5 0.9 2.2 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Syntaxin_2 PF14523.6 KII72342.1 - 0.44 10.9 12.4 0.058 13.8 4.2 2.4 1 1 1 2 2 2 0 Syntaxin-like protein Baculo_PEP_C PF04513.12 KII72342.1 - 0.45 10.6 9.1 9.1 6.3 9.1 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CorA PF01544.18 KII72342.1 - 0.45 9.8 11.9 0.79 9.0 11.9 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DASH_Duo1 PF08651.10 KII72342.1 - 0.47 10.3 11.5 1.4 8.8 2.3 3.0 2 1 1 3 3 3 0 DASH complex subunit Duo1 CENP-H PF05837.12 KII72342.1 - 0.56 10.6 8.6 8.8 6.8 3.1 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF2203 PF09969.9 KII72342.1 - 0.65 10.7 4.4 4.2 8.1 0.2 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) RPW8 PF05659.11 KII72342.1 - 0.98 9.1 7.6 3.1 7.5 7.5 1.9 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Arc_PepC_II PF06847.11 KII72342.1 - 1 9.9 5.4 1.7 9.2 1.2 2.7 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Med9 PF07544.13 KII72342.1 - 1.2 9.3 8.5 0.12 12.5 0.6 2.6 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 APG6_N PF17675.1 KII72342.1 - 1.2 9.6 9.2 1.3 9.6 2.0 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Prefoldin_2 PF01920.20 KII72342.1 - 1.4 8.9 15.2 0.61 10.1 1.4 2.8 2 1 1 3 3 3 0 Prefoldin subunit ABC_tran_CTD PF16326.5 KII72342.1 - 1.7 8.9 8.8 2 8.7 1.9 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain UPF0242 PF06785.11 KII72342.1 - 1.7 8.7 14.6 1.3 9.1 6.2 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus XhlA PF10779.9 KII72342.1 - 1.8 8.8 15.6 0.37 11.0 5.5 2.5 2 0 0 2 2 2 0 Haemolysin XhlA DUF641 PF04859.12 KII72342.1 - 1.9 8.8 8.3 4.1 7.7 4.3 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FliD_N PF02465.18 KII72342.1 - 2 9.2 8.3 12 6.7 2.0 2.4 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF4665 PF15679.5 KII72342.1 - 2.5 8.7 11.4 16 6.1 3.4 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) FadA PF09403.10 KII72342.1 - 3.2 8.3 15.5 0.61 10.6 3.0 2.7 2 1 0 2 2 2 0 Adhesion protein FadA Rad50_zn_hook PF04423.14 KII72342.1 - 3.4 7.6 6.0 23 4.9 0.2 3.4 2 1 1 3 3 3 0 Rad50 zinc hook motif TMPIT PF07851.13 KII72342.1 - 3.7 6.7 8.2 35 3.5 8.1 2.0 1 1 0 1 1 1 0 TMPIT-like protein FlaC_arch PF05377.11 KII72342.1 - 6.1 7.3 12.1 5 7.6 0.8 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DASH_Dad4 PF08650.10 KII72342.1 - 8 6.5 11.3 3.7 7.6 2.0 3.2 1 1 2 3 3 3 0 DASH complex subunit Dad4 zf-H2C2_5 PF13909.6 KII72344.1 - 2.3e-09 36.8 3.2 2.4e-06 27.2 0.0 3.2 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 KII72344.1 - 0.00012 22.4 0.1 0.00012 22.4 0.1 3.5 3 1 0 3 3 3 1 Zinc-finger double domain OrsD PF12013.8 KII72344.1 - 0.0034 17.8 0.3 0.0034 17.8 0.3 2.3 2 1 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_4 PF13894.6 KII72344.1 - 0.0068 17.2 12.2 2.5 9.2 0.1 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KII72344.1 - 0.52 10.9 14.5 11 6.7 0.2 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type Collagen PF01391.18 KII72345.1 - 3e-06 26.9 13.2 3e-06 26.9 13.2 2.0 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) zf-CCCH PF00642.24 KII72346.1 - 4.4e-05 23.3 2.2 7.8e-05 22.5 2.2 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 KII72346.1 - 0.0002 21.1 0.0 0.00039 20.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 KII72346.1 - 1.4 9.1 8.3 0.3 11.2 4.6 1.9 2 0 0 2 2 2 0 Zinc finger domain ADH_zinc_N PF00107.26 KII72347.1 - 2.1e-27 95.7 0.2 3.1e-27 95.1 0.2 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KII72347.1 - 5.9e-10 39.0 0.1 7.9e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 KII72347.1 - 2.6e-07 31.7 0.0 6.4e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase MTS PF05175.14 KII72347.1 - 0.022 14.3 0.1 1.7 8.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain AlaDh_PNT_C PF01262.21 KII72347.1 - 0.17 11.2 2.8 0.25 10.6 2.8 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SCPU PF05229.15 KII72348.1 - 6.2e-05 23.4 1.3 7.5e-05 23.2 1.3 1.2 1 0 0 1 1 1 1 Spore Coat Protein U domain Fimbrial PF00419.20 KII72348.1 - 0.0024 18.1 1.2 0.0028 17.9 1.2 1.1 1 0 0 1 1 1 1 Fimbrial protein DUF4402 PF14352.6 KII72348.1 - 0.022 15.4 2.6 0.029 15.0 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4402) Fimbrial PF00419.20 KII72349.1 - 1.1e-12 48.5 0.5 1.4e-12 48.2 0.5 1.1 1 0 0 1 1 1 1 Fimbrial protein Big_3_5 PF16640.5 KII72349.1 - 0.063 13.5 1.9 0.13 12.5 1.9 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) Usher PF00577.20 KII72350.1 - 1.5e-137 459.8 22.8 1.7e-137 459.6 22.8 1.0 1 0 0 1 1 1 1 Outer membrane usher protein PapC_C PF13953.6 KII72350.1 - 7.1e-22 77.0 0.0 3.7e-21 74.7 0.0 2.3 2 0 0 2 2 2 1 PapC C-terminal domain PapD_C PF02753.17 KII72351.1 - 3e-12 46.7 0.5 4.6e-12 46.1 0.5 1.2 1 0 0 1 1 1 1 Pili assembly chaperone PapD, C-terminal domain PapD_N PF00345.20 KII72351.1 - 3.1e-05 23.9 0.1 8.6e-05 22.4 0.0 1.8 2 0 0 2 2 2 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain DUF5001 PF16392.5 KII72351.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Ig-like domain Mem_trans PF03547.18 KII72352.1 - 1.5e-30 105.9 37.3 1.2e-15 56.8 12.5 2.0 1 1 1 2 2 2 2 Membrane transport protein LysR_substrate PF03466.20 KII72353.1 - 3.9e-19 68.9 0.0 5.4e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 KII72353.1 - 1.5e-12 47.3 0.3 2.5e-12 46.5 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_3 PF01381.22 KII72353.1 - 0.07 13.2 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix HTH_8 PF02954.19 KII72353.1 - 0.1 12.4 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Bac_surface_Ag PF01103.23 KII72354.1 - 1.2e-92 310.9 16.1 2e-92 310.2 16.1 1.4 1 0 0 1 1 1 1 Surface antigen POTRA PF07244.15 KII72354.1 - 3.4e-57 191.0 6.6 2.5e-15 56.8 0.1 5.6 5 0 0 5 5 5 5 Surface antigen variable number repeat POTRA_2 PF08479.11 KII72354.1 - 1.9e-05 24.4 1.0 0.42 10.5 0.0 5.0 6 0 0 6 6 6 2 POTRA domain, ShlB-type POTRA_1 PF08478.10 KII72354.1 - 6.4e-05 23.2 1.0 0.1 12.9 0.0 3.7 4 0 0 4 4 4 2 POTRA domain, FtsQ-type YqfD PF06898.11 KII72354.1 - 0.019 13.8 0.2 2.2 7.0 0.0 3.0 2 1 1 3 3 3 0 Putative stage IV sporulation protein YqfD HTH_18 PF12833.7 KII72355.1 - 4.5e-16 58.9 0.1 7e-16 58.3 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 KII72355.1 - 6.4e-12 45.2 0.3 4.5e-07 29.8 0.1 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family TonB_dep_Rec PF00593.24 KII72356.1 - 9.7e-32 111.4 15.8 1.1e-31 111.3 15.8 1.0 1 0 0 1 1 1 1 TonB dependent receptor IBP39 PF11422.8 KII72357.1 - 0.012 15.4 2.9 1.8 8.3 0.0 2.3 1 1 0 2 2 2 0 Initiator binding protein 39 kDa Kunitz_BPTI PF00014.23 KII72359.1 - 0.00097 19.3 7.5 0.041 14.1 0.1 2.9 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Kunitz_BPTI PF00014.23 KII72360.1 - 1.2e-05 25.4 4.2 0.00032 20.9 1.1 2.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain RICTOR_M PF14666.6 KII72364.1 - 4.6 7.1 7.2 4.5 7.1 0.1 3.7 3 1 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain ERAP1_C PF11838.8 KII72365.1 - 1.2e-07 31.6 0.0 1.4e-07 31.3 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 KII72366.1 - 2e-66 223.7 1.8 2.8e-66 223.2 1.8 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KII72366.1 - 2.4e-23 83.3 0.2 4.6e-23 82.4 0.2 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 KII72366.1 - 3.7e-18 66.1 0.0 6.1e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain IstB_IS21_ATP PF08483.11 KII72366.1 - 0.022 14.7 0.3 0.053 13.4 0.3 1.6 1 0 0 1 1 1 0 IstB-like ATP binding N-terminal DUF2031 PF09592.10 KII72366.1 - 0.068 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) Meleagrin PF08189.11 KII72367.1 - 0.085 12.6 0.6 0.21 11.3 0.6 1.6 1 0 0 1 1 1 0 Meleagrin/Cygnin family EF-hand_4 PF12763.7 KII72368.1 - 1.1e-19 70.3 0.0 6.1e-09 35.8 0.0 2.6 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SH3_1 PF00018.28 KII72368.1 - 8.5e-18 63.7 2.3 8.6e-07 28.5 0.0 3.4 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 KII72368.1 - 6.7e-15 54.7 0.0 9.7e-08 31.8 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 KII72368.1 - 5e-12 45.3 0.1 0.0014 18.3 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain EF-hand_1 PF00036.32 KII72368.1 - 6.4e-08 31.6 0.2 0.022 14.3 0.0 3.1 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KII72368.1 - 3.1e-06 27.5 0.0 0.058 13.9 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KII72368.1 - 0.0038 17.0 0.5 4.7 7.4 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KII72368.1 - 0.06 13.2 0.1 16 5.4 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair AAA_34 PF13872.6 KII72369.1 - 1.3e-129 431.4 0.0 2.1e-129 430.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 KII72369.1 - 6.5e-106 354.0 0.0 1e-105 353.3 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 KII72369.1 - 0.00011 22.3 0.0 0.00024 21.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KII72369.1 - 0.028 14.8 0.2 0.1 12.9 0.1 2.1 2 0 0 2 2 2 0 Helicase conserved C-terminal domain CDO_I PF05995.12 KII72370.1 - 4.6e-25 87.9 0.1 5.4e-25 87.7 0.1 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 KII72370.1 - 3.2e-05 23.5 0.3 3.9e-05 23.2 0.3 1.2 1 0 0 1 1 1 1 PCO_ADO NRDE-2 PF08424.10 KII72370.1 - 0.0089 15.2 1.1 0.012 14.7 1.1 1.1 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference IMD PF08397.11 KII72370.1 - 0.045 13.1 1.2 0.069 12.5 0.5 1.6 2 0 0 2 2 2 0 IRSp53/MIM homology domain BRE1 PF08647.11 KII72370.1 - 0.26 11.4 7.3 1.9 8.6 2.2 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase CDO_I PF05995.12 KII72371.1 - 4.2e-24 84.8 0.2 1.1e-23 83.4 0.0 1.7 2 0 0 2 2 2 1 Cysteine dioxygenase type I Cupin_7 PF12973.7 KII72371.1 - 0.022 14.7 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 ChrR Cupin-like domain Aminotran_1_2 PF00155.21 KII72373.1 - 3.1e-34 118.7 0.0 3.8e-34 118.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KII72373.1 - 0.0069 15.7 0.0 0.0099 15.2 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 KII72374.1 - 1.2e-87 294.3 0.0 1.6e-87 293.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KII72374.1 - 1.7e-08 34.2 0.1 2.5e-08 33.6 0.1 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 KII72374.1 - 1.8e-08 34.0 0.0 2.3e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 KII72374.1 - 3e-07 29.9 0.0 4.8e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Pyridoxal_deC PF00282.19 KII72374.1 - 5.1e-05 22.2 0.0 9.7e-05 21.2 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 KII72374.1 - 0.0002 20.0 0.0 0.00031 19.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme YbhQ PF11076.8 KII72375.1 - 0.034 14.2 0.0 0.041 13.9 0.0 1.1 1 0 0 1 1 1 0 Putative inner membrane protein YbhQ PAP_fibrillin PF04755.12 KII72375.1 - 0.09 12.7 0.2 0.11 12.4 0.2 1.1 1 0 0 1 1 1 0 PAP_fibrillin Ig_J_chain PF15097.6 KII72376.1 - 0.0082 16.0 0.7 0.0096 15.8 0.7 1.2 1 0 0 1 1 1 1 Immunoglobulin J chain Pox_EPC_I2-L1 PF12575.8 KII72377.1 - 0.11 12.7 0.3 0.11 12.7 0.3 1.8 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Endomucin PF07010.12 KII72378.1 - 0.0082 16.1 0.5 0.0099 15.9 0.5 1.1 1 0 0 1 1 1 1 Endomucin Pox_EPC_I2-L1 PF12575.8 KII72378.1 - 0.027 14.7 0.4 0.066 13.4 0.4 1.6 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 DUF3404 PF11884.8 KII72380.1 - 0.22 10.7 2.9 0.44 9.7 2.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3404) MttA_Hcf106 PF02416.16 KII72381.1 - 0.28 10.5 3.5 0.52 9.7 3.5 1.4 1 0 0 1 1 1 0 mttA/Hcf106 family RelB_N PF18506.1 KII72383.1 - 0.04 13.7 0.9 0.073 12.9 0.9 1.4 1 0 0 1 1 1 0 RelB Antitoxin alpha helical domain RRM_2 PF04059.12 KII72384.1 - 0.21 11.8 6.4 0.11 12.7 1.5 2.7 2 2 1 3 3 3 0 RNA recognition motif 2 Ribosomal_L28 PF00830.19 KII72384.1 - 4 7.7 6.3 1.3 9.3 1.1 2.7 2 1 0 2 2 2 0 Ribosomal L28 family Ribosomal_L28 PF00830.19 KII72385.1 - 0.3 11.3 1.8 0.45 10.8 1.8 1.2 1 0 0 1 1 1 0 Ribosomal L28 family Integrase_H2C2 PF17921.1 KII72387.1 - 1e-07 31.9 0.0 2.6e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Sortilin_C PF15901.5 KII72390.1 - 3.9e-11 43.6 0.2 7.5e-11 42.7 0.2 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72390.1 - 5.4e-07 28.8 5.1 2.3e-06 26.7 5.1 1.8 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72390.1 - 0.0024 17.6 1.9 1.4 9.2 0.0 3.5 3 0 0 3 3 3 2 BNR/Asp-box repeat APC_u14 PF16635.5 KII72391.1 - 0.014 15.9 2.1 0.024 15.2 2.1 1.3 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr SNAP PF14938.6 KII72392.1 - 0.0031 17.0 0.5 0.0042 16.6 0.5 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DHQ_synthase PF01761.20 KII72392.1 - 0.0035 16.6 0.4 0.0053 15.9 0.4 1.4 1 0 0 1 1 1 1 3-dehydroquinate synthase PA_decarbox PF05870.11 KII72392.1 - 0.0067 16.1 0.2 0.013 15.1 0.1 1.5 1 1 0 1 1 1 1 Phenolic acid decarboxylase (PAD) AAA_14 PF13173.6 KII72392.1 - 0.6 10.1 4.0 0.36 10.9 1.8 1.7 2 1 0 2 2 2 0 AAA domain TIP49 PF06068.13 KII72393.1 - 2.8e-82 276.7 0.1 3.6e-82 276.4 0.1 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KII72393.1 - 1.5e-21 76.3 0.1 3e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA_22 PF13401.6 KII72393.1 - 0.069 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 KII72394.1 - 4.9e-49 167.4 1.6 5.7e-49 167.2 1.6 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain AAA PF00004.29 KII72394.1 - 7.6e-08 32.9 0.2 1.2e-07 32.2 0.2 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 KII72394.1 - 1.1e-06 28.2 0.1 1.4e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain RuvB_N PF05496.12 KII72394.1 - 1.5e-05 24.8 0.1 2.1e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF2075 PF09848.9 KII72394.1 - 0.00028 20.2 0.0 0.00035 19.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 KII72394.1 - 0.00071 19.6 0.1 0.0012 18.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KII72394.1 - 0.0008 19.8 0.1 0.0011 19.4 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 KII72394.1 - 0.0014 18.1 0.3 0.0019 17.6 0.3 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 KII72394.1 - 0.0021 17.5 1.5 0.0027 17.1 1.2 1.4 1 1 0 1 1 1 1 KaiC NACHT PF05729.12 KII72394.1 - 0.0033 17.4 0.1 0.0045 16.9 0.1 1.3 1 0 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 KII72394.1 - 0.0039 16.7 0.0 0.0043 16.6 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 KII72394.1 - 0.0073 15.6 0.5 0.01 15.1 0.5 1.3 1 0 0 1 1 1 1 Zeta toxin TsaE PF02367.17 KII72394.1 - 0.0094 15.9 0.3 0.014 15.4 0.3 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 KII72394.1 - 0.014 15.2 0.1 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KII72394.1 - 0.015 14.9 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KII72394.1 - 0.015 15.8 0.1 0.023 15.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KII72394.1 - 0.018 15.4 0.5 0.028 14.7 0.4 1.5 2 0 0 2 2 1 0 AAA domain AAA_32 PF13654.6 KII72394.1 - 0.02 13.7 0.1 0.026 13.3 0.1 1.1 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KII72394.1 - 0.039 14.1 0.0 0.063 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KII72394.1 - 0.041 13.6 0.1 0.055 13.2 0.1 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 KII72394.1 - 0.043 13.5 0.1 0.057 13.1 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 KII72394.1 - 0.061 13.6 0.1 0.089 13.1 0.1 1.2 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KII72394.1 - 0.091 11.9 0.1 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain Parvo_NS1 PF01057.17 KII72394.1 - 0.1 11.7 0.2 0.13 11.4 0.2 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 KII72394.1 - 0.1 13.0 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase GvpD PF07088.11 KII72394.1 - 0.15 10.6 0.3 0.22 10.1 0.3 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein ResIII PF04851.15 KII72394.1 - 0.26 11.3 1.1 0.38 10.7 1.1 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF1479 PF07350.12 KII72395.1 - 0.036 12.8 0.0 0.038 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) HSP70 PF00012.20 KII72396.1 - 7.7e-74 248.9 0.0 9.6e-74 248.6 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KII72396.1 - 2.3e-11 43.1 0.0 9.9e-11 41.0 0.0 1.9 2 1 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 KII72396.1 - 0.021 15.3 0.1 0.22 12.0 0.0 2.6 2 1 0 2 2 2 0 Cell division protein FtsA DDR PF08841.10 KII72396.1 - 0.047 12.7 0.0 0.22 10.5 0.0 1.9 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain StbA PF06406.11 KII72396.1 - 0.071 12.3 0.0 0.62 9.3 0.0 2.0 2 0 0 2 2 2 0 StbA protein DUF1726 PF08351.11 KII72397.1 - 0.069 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1726) Serpin PF00079.20 KII72401.1 - 6.8e-25 88.1 4.5 7.1e-25 88.1 4.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ribosomal_L1 PF00687.21 KII72402.1 - 6.7e-41 140.3 3.8 8.3e-41 140.0 3.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Serpin PF00079.20 KII72403.1 - 2.2e-31 109.5 0.0 2.3e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RT_RNaseH PF17917.1 KII72405.1 - 5.6e-33 113.4 0.0 8.9e-33 112.7 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72405.1 - 1.7e-26 92.1 0.0 2.7e-26 91.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase SatRNA_48 PF17485.2 KII72405.1 - 0.085 12.0 0.2 0.11 11.5 0.2 1.2 1 0 0 1 1 1 0 Satellite RNA 48 kDa protein DDE_Tnp_IS1595 PF12762.7 KII72407.1 - 0.00015 21.8 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF5363 PF17320.2 KII72407.1 - 0.085 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5363) Exo_endo_phos PF03372.23 KII72409.1 - 6.6e-09 35.6 0.0 8.8e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 KII72409.1 - 0.00023 21.0 1.6 0.0017 18.2 0.4 2.7 2 1 0 2 2 2 1 RhoGAP domain DUF5100 PF17029.5 KII72409.1 - 0.0039 17.0 0.1 0.11 12.3 0.1 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5100) PHD PF00628.29 KII72410.1 - 2.8e-06 27.1 10.2 2.8e-06 27.1 10.2 4.0 4 1 0 4 4 4 1 PHD-finger zf-NF-X1 PF01422.17 KII72410.1 - 1.1e-05 25.4 16.4 1.1e-05 25.4 16.4 5.0 6 1 1 7 7 7 2 NF-X1 type zinc finger Homeodomain PF00046.29 KII72412.1 - 1.3e-19 69.8 8.7 2.6e-19 68.8 8.7 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KII72412.1 - 0.0071 16.2 1.4 0.015 15.2 1.4 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 KII72412.1 - 0.065 12.7 0.7 0.11 11.9 0.1 1.7 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez NMT_C PF02799.15 KII72416.1 - 1.4e-16 60.7 0.6 1.7e-16 60.4 0.6 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 KII72417.1 - 2e-46 157.7 0.0 2.5e-46 157.4 0.0 1.0 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 KII72417.1 - 5.9e-05 23.2 0.0 7.7e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NOA36 PF06524.12 KII72418.1 - 1.6 7.9 9.7 2 7.6 9.7 1.1 1 0 0 1 1 1 0 NOA36 protein Homeodomain PF00046.29 KII72421.1 - 2.1e-19 69.1 3.7 4.1e-19 68.2 3.7 1.5 1 0 0 1 1 1 1 Homeodomain YdaS_antitoxin PF15943.5 KII72421.1 - 0.011 15.6 0.4 0.083 12.8 0.0 2.2 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Annexin PF00191.20 KII72422.1 - 1e-08 35.1 4.8 0.0011 19.0 0.5 3.9 4 0 0 4 4 4 2 Annexin Annexin PF00191.20 KII72424.1 - 0.00065 19.7 0.9 0.0013 18.8 0.3 1.8 2 0 0 2 2 2 1 Annexin Annexin PF00191.20 KII72425.1 - 5.1e-09 36.1 2.4 0.0003 20.8 0.5 2.2 2 0 0 2 2 2 2 Annexin GDE_C PF06202.14 KII72425.1 - 0.2 10.5 0.0 0.25 10.2 0.0 1.1 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Exo_endo_phos PF03372.23 KII72426.1 - 9e-08 31.9 0.0 1.1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-NF-X1 PF01422.17 KII72427.1 - 0.0062 16.6 19.3 0.0062 16.6 19.3 5.3 5 2 1 6 6 6 2 NF-X1 type zinc finger Cpn60_TCP1 PF00118.24 KII72429.1 - 1.7e-85 287.5 13.8 7.9e-85 285.3 13.8 1.8 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family La PF05383.17 KII72430.1 - 1.8e-17 63.1 1.1 3.4e-17 62.2 1.1 1.5 1 0 0 1 1 1 1 La domain tRNA_int_endo PF01974.17 KII72433.1 - 2.3e-05 24.3 0.6 3.2e-05 23.9 0.6 1.2 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain DUF1647 PF07801.11 KII72433.1 - 0.00086 19.1 2.1 0.0011 18.7 2.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) tRNA_int_endo_N PF02778.14 KII72433.1 - 0.019 14.6 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain SRP1_TIP1 PF00660.17 KII72434.1 - 0.028 14.5 0.8 4.5 7.4 0.2 3.2 2 1 1 3 3 3 0 Seripauperin and TIP1 family OSTMP1 PF09777.9 KII72435.1 - 0.025 14.0 0.5 0.025 14.0 0.5 1.6 1 1 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor MFS_1 PF07690.16 KII72436.1 - 2.9e-31 108.7 28.5 7.6e-27 94.2 25.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KII72436.1 - 1.9 7.2 22.6 2.2 7.0 8.6 2.2 2 0 0 2 2 2 0 Sugar (and other) transporter TMEM132D_C PF15706.5 KII72437.1 - 0.045 13.5 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TRAP_beta PF05753.14 KII72438.1 - 0.029 13.8 0.3 0.086 12.2 0.1 1.8 2 0 0 2 2 2 0 Translocon-associated protein beta (TRAPB) PAS_6 PF08348.11 KII72438.1 - 0.44 10.4 4.0 0.44 10.4 0.4 2.3 1 1 1 2 2 2 0 YheO-like PAS domain DUF1129 PF06570.11 KII72440.1 - 0.0028 17.2 0.2 0.18 11.3 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1129) MVL PF12151.8 KII72440.1 - 0.22 11.4 0.4 6.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Mannan-binding protein Phage_GPO PF05929.11 KII72441.1 - 0.14 11.7 0.1 0.14 11.7 0.1 2.2 3 0 0 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF1656 PF07869.12 KII72442.1 - 0.2 11.7 4.2 9.9 6.3 1.5 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1656) RVT_1 PF00078.27 KII72443.1 - 8.5e-06 25.4 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Uso1_p115_head PF04869.14 KII72444.1 - 0.088 11.9 1.0 0.09 11.9 1.0 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region Endothelin PF00322.17 KII72445.1 - 0.025 14.2 4.2 0.32 10.6 1.5 2.8 2 0 0 2 2 2 0 Endothelin family DUF508 PF04370.12 KII72445.1 - 0.1 12.3 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Kunitz_BPTI PF00014.23 KII72445.1 - 0.12 12.6 10.3 0.051 13.8 4.2 2.8 2 2 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain WD40 PF00400.32 KII72446.1 - 4.2e-22 78.0 7.5 4.7e-08 33.6 0.0 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII72446.1 - 0.0011 19.2 0.1 1.7 9.0 0.1 3.2 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KII72446.1 - 0.0016 17.8 0.2 0.013 14.8 0.1 2.3 2 1 1 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 KII72446.1 - 0.0069 15.4 2.2 0.028 13.4 0.4 2.5 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 KII72446.1 - 0.015 14.1 1.5 1.5 7.5 0.0 3.2 1 1 1 3 3 3 0 Nup133 N terminal like BBS2_Mid PF14783.6 KII72446.1 - 0.016 15.2 0.0 3.9 7.6 0.0 3.1 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DUF5640 PF18692.1 KII72446.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5640) Ribosomal_L37 PF08561.10 KII72447.1 - 3.5e-07 30.8 1.4 8.3e-07 29.6 1.4 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L37 Pro_isomerase PF00160.21 KII72448.1 - 6.3e-30 104.5 0.2 6.9e-30 104.4 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DnaB_2 PF07261.11 KII72451.1 - 0.55 10.0 3.0 2.9 7.7 1.0 3.0 2 2 2 4 4 4 0 Replication initiation and membrane attachment Aminotran_1_2 PF00155.21 KII72452.1 - 1.9e-25 89.8 0.0 2.7e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II zf-UBR PF02207.20 KII72453.1 - 2.8e-17 62.6 18.9 2.8e-17 62.6 18.9 3.5 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) ELL PF10390.9 KII72453.1 - 0.019 14.5 0.5 0.036 13.5 0.5 1.4 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL Stc1 PF12898.7 KII72454.1 - 0.043 14.4 2.0 0.058 13.9 2.0 1.3 1 0 0 1 1 1 0 Stc1 domain IP_trans PF02121.18 KII72455.1 - 1.3e-37 129.8 0.2 1.5e-37 129.5 0.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Alg14 PF08660.11 KII72459.1 - 9.1e-54 182.0 0.1 1e-53 181.9 0.1 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like zf-C2H2 PF00096.26 KII72460.1 - 6.7e-14 51.5 24.8 7.4e-05 23.0 3.0 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KII72460.1 - 1.9e-11 43.8 8.8 5.8e-09 36.0 2.0 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KII72460.1 - 3.5e-08 33.6 21.0 0.00035 21.1 1.9 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KII72460.1 - 0.00097 19.1 2.1 0.00097 19.1 2.1 3.3 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KII72460.1 - 0.0018 18.6 4.7 0.0055 17.0 4.7 2.0 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-RING_4 PF14570.6 KII72460.1 - 0.064 13.1 0.6 0.064 13.1 0.6 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain FOXP-CC PF16159.5 KII72460.1 - 1.9 9.2 6.6 1.5 9.5 0.6 2.7 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-met PF12874.7 KII72460.1 - 6.7 7.2 12.4 1.4 9.4 1.1 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DDE_Tnp_IS1595 PF12762.7 KII72462.1 - 0.0049 16.9 0.0 0.0068 16.4 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain COX4 PF02936.14 KII72463.1 - 0.0029 17.6 0.1 0.0053 16.8 0.1 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV T2SSC PF11356.8 KII72464.1 - 0.039 13.9 0.1 0.1 12.5 0.0 1.7 2 0 0 2 2 2 0 Type II secretion system protein C LPP20 PF02169.16 KII72464.1 - 0.14 12.5 2.2 0.32 11.4 2.2 1.6 1 0 0 1 1 1 0 LPP20 lipoprotein DUF359 PF04019.12 KII72464.1 - 0.52 10.0 2.2 0.56 9.9 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF359) UPF0172 PF03665.13 KII72466.1 - 0.011 15.8 0.5 0.16 12.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) Pet20 PF08692.10 KII72466.1 - 1.2 9.9 7.3 0.28 11.9 3.4 1.9 1 1 0 2 2 2 0 Mitochondrial protein Pet20 DDE_Tnp_IS1595 PF12762.7 KII72467.1 - 0.017 15.1 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain Ribosomal_L22 PF00237.19 KII72468.1 - 5.9e-35 119.6 0.1 7.3e-35 119.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e FAD_binding_1 PF00667.20 KII72469.1 - 2.2e-27 96.1 0.1 3.3e-27 95.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KII72469.1 - 3.5e-22 79.1 0.0 6.4e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KII72469.1 - 2.7e-06 28.0 0.0 8.2e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain PARM PF17061.5 KII72470.1 - 0.32 11.1 5.7 0.43 10.7 5.7 1.1 1 0 0 1 1 1 0 PARM PRA1 PF03208.19 KII72471.1 - 0.014 15.1 0.2 0.022 14.4 0.2 1.2 1 0 0 1 1 1 0 PRA1 family protein LUC7 PF03194.15 KII72473.1 - 3.3e-34 118.7 0.1 6.5e-24 85.0 0.0 2.0 1 1 1 2 2 2 2 LUC7 N_terminus zf-CCCH_4 PF18044.1 KII72473.1 - 0.17 11.8 0.6 0.17 11.8 0.6 2.1 2 0 0 2 2 2 0 CCCH-type zinc finger GNT-I PF03071.15 KII72474.1 - 5e-30 104.6 0.5 8.9e-30 103.8 0.5 1.5 1 1 0 1 1 1 1 GNT-I family Glyco_transf_25 PF01755.17 KII72474.1 - 0.058 13.3 0.8 0.34 10.7 0.3 2.2 2 1 0 2 2 2 0 Glycosyltransferase family 25 (LPS biosynthesis protein) NAC PF01849.18 KII72475.1 - 0.0037 17.2 0.1 0.012 15.5 0.0 1.8 2 0 0 2 2 2 1 NAC domain KRBA1 PF15287.6 KII72477.1 - 0.035 13.8 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 KRBA1 family repeat GNT-I PF03071.15 KII72478.1 - 3.3e-14 52.5 1.9 1.5e-13 50.3 1.9 1.8 1 1 0 1 1 1 1 GNT-I family Glyco_transf_25 PF01755.17 KII72478.1 - 0.0016 18.3 2.9 0.0053 16.6 1.1 2.1 2 0 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) NAC PF01849.18 KII72478.1 - 0.0067 16.4 0.1 0.024 14.6 0.0 1.9 2 0 0 2 2 2 1 NAC domain GNT-I PF03071.15 KII72479.1 - 5.6e-35 120.9 0.5 3.1e-34 118.5 0.4 1.9 1 1 0 1 1 1 1 GNT-I family MGAT2 PF05060.14 KII72479.1 - 1.4e-06 27.6 0.0 0.044 12.8 0.0 2.2 2 0 0 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) Glyco_transf_25 PF01755.17 KII72479.1 - 0.022 14.6 0.1 0.038 13.8 0.1 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_3 PF13641.6 KII72479.1 - 0.046 13.6 0.0 0.15 12.0 0.0 1.9 1 1 0 1 1 1 0 Glycosyltransferase like family 2 MutL PF13941.6 KII72480.1 - 0.081 11.5 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 MutL protein ILEI PF15711.5 KII72481.1 - 0.045 14.2 0.0 0.074 13.5 0.0 1.4 1 1 0 1 1 1 0 Interleukin-like EMT inducer GNT-I PF03071.15 KII72482.1 - 3.9e-30 105.0 1.2 6.6e-30 104.2 1.2 1.5 1 1 0 1 1 1 1 GNT-I family MGAT2 PF05060.14 KII72482.1 - 5.3e-05 22.5 0.1 8.3e-05 21.8 0.1 1.3 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) Glyco_transf_25 PF01755.17 KII72482.1 - 0.00056 19.8 1.6 0.0021 17.9 0.7 2.1 2 0 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) DDE_3 PF13358.6 KII72487.1 - 3.3e-12 46.4 0.1 4.8e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1758 PF05585.12 KII72490.1 - 0.0089 15.8 0.1 0.013 15.3 0.1 1.2 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Tam41_Mmp37 PF09139.11 KII72492.1 - 2.1e-75 254.2 0.5 3.1e-75 253.6 0.5 1.3 1 1 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Viral_cys_rich PF08008.12 KII72493.1 - 0.06 13.4 0.0 0.097 12.7 0.0 1.4 1 1 0 1 1 1 0 Viral cysteine rich Inhibitor_I53 PF11714.8 KII72495.1 - 0.089 13.0 1.7 0.12 12.6 0.1 2.0 1 1 0 2 2 2 0 Thrombin inhibitor Madanin DDE_3 PF13358.6 KII72496.1 - 3.3e-18 65.8 0.3 4e-18 65.6 0.3 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RapH_N PF18801.1 KII72496.1 - 0.026 14.6 1.4 0.72 10.0 0.1 2.5 2 1 0 2 2 2 0 response regulator aspartate phosphatase H, N terminal ITAM_Cys-rich PF10538.9 KII72496.1 - 0.044 13.6 0.3 0.078 12.8 0.3 1.4 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif Adap_comp_sub PF00928.21 KII72496.1 - 0.055 12.8 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 Adaptor complexes medium subunit family Plus-3 PF03126.18 KII72497.1 - 0.013 16.0 1.8 0.023 15.2 0.2 2.1 2 1 0 2 2 2 0 Plus-3 domain DUF4371 PF14291.6 KII72497.1 - 0.022 14.4 0.3 0.027 14.1 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) DUF1090 PF06476.12 KII72497.1 - 0.53 10.4 9.9 0.24 11.5 4.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1090) Bap31_Bap29_C PF18035.1 KII72497.1 - 7.3 6.7 9.2 40 4.3 1.7 4.0 2 2 2 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain DDE_3 PF13358.6 KII72498.1 - 0.027 14.2 0.0 0.032 14.0 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease PS_Dcarbxylase PF02666.15 KII72499.1 - 3.6e-33 114.8 0.1 5.5e-33 114.2 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase RabGAP-TBC PF00566.18 KII72500.1 - 1e-23 84.2 12.1 1.6e-23 83.5 12.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 KII72500.1 - 0.066 12.7 0.0 0.4 10.1 0.0 2.0 2 0 0 2 2 2 0 Rab-binding domain (RBD) Ribosomal_L7Ae PF01248.26 KII72501.1 - 1.2e-17 63.4 0.0 1.5e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Rad51 PF08423.11 KII72503.1 - 7.8e-21 74.5 0.1 8.9e-21 74.3 0.1 1.0 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 KII72503.1 - 9.3e-07 28.6 0.1 2.3e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 recA bacterial DNA recombination protein ATPase PF06745.13 KII72503.1 - 1.3e-06 28.0 0.1 3.8e-06 26.4 0.1 1.8 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 KII72503.1 - 1.4e-06 28.0 0.0 5e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain Bac_DnaA PF00308.18 KII72503.1 - 2.8e-05 24.1 0.2 4.1e-05 23.5 0.2 1.2 1 0 0 1 1 1 1 Bacterial dnaA protein AAA_24 PF13479.6 KII72503.1 - 0.00031 20.5 0.2 0.00057 19.7 0.2 1.3 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 KII72503.1 - 0.00044 20.2 0.0 0.00063 19.7 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 KII72503.1 - 0.00095 19.4 0.1 0.0018 18.5 0.1 1.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KII72503.1 - 0.0079 16.6 0.2 0.021 15.2 0.2 1.8 1 1 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 KII72503.1 - 0.013 15.4 0.7 0.034 14.1 0.7 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea PhoH PF02562.16 KII72503.1 - 0.015 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.9 KII72503.1 - 0.016 14.5 0.0 0.017 14.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 KII72503.1 - 0.018 15.5 0.0 0.025 15.1 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 KII72503.1 - 0.02 15.3 0.0 0.025 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 KII72503.1 - 0.04 14.3 0.0 0.062 13.7 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 KII72503.1 - 0.053 13.3 0.1 0.082 12.6 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein TniB PF05621.11 KII72503.1 - 0.057 12.8 0.0 0.17 11.2 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein DnaB_C PF03796.15 KII72503.1 - 0.061 12.7 0.0 0.47 9.7 0.0 2.0 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain NB-ARC PF00931.22 KII72503.1 - 0.12 11.5 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain SRP54 PF00448.22 KII72503.1 - 0.13 11.8 0.0 0.21 11.2 0.0 1.4 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain DEAD PF00270.29 KII72503.1 - 0.16 11.7 0.5 0.37 10.5 0.5 1.8 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_19 PF13245.6 KII72503.1 - 0.16 12.3 0.0 0.31 11.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain HMD PF03201.16 KII72507.1 - 0.0068 16.6 0.4 0.33 11.2 0.0 3.1 2 1 1 3 3 3 1 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Pro-NT_NN PF07421.11 KII72507.1 - 0.025 14.8 0.4 2.4 8.4 0.0 3.3 2 1 1 3 3 3 0 Neurotensin/neuromedin N precursor DCB PF16213.5 KII72507.1 - 0.81 9.3 3.5 23 4.6 0.2 3.0 3 0 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 DUF5638 PF18688.1 KII72507.1 - 1.3 9.3 8.2 1.7 9.0 0.2 3.4 2 1 1 3 3 3 0 Family of unknown function (DUF5638) Vac14_Fab1_bd PF12755.7 KII72507.1 - 4.7 7.9 9.0 3.3 8.4 0.1 3.3 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region Sortilin_C PF15901.5 KII72511.1 - 5e-22 79.0 5.7 8.7e-22 78.2 5.7 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72511.1 - 3.6e-08 32.6 0.1 1.2e-05 24.4 0.1 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72511.1 - 0.0015 18.2 3.1 0.79 10.0 0.1 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat STT3 PF02516.14 KII72513.1 - 1.8e-87 294.3 37.0 4.8e-87 292.9 37.0 1.5 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 KII72513.1 - 0.0005 20.3 15.1 0.0005 20.3 15.1 3.5 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Carboxyl_trans PF01039.22 KII72514.1 - 1.2e-61 208.9 0.6 1.3e-61 208.8 0.6 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 KII72514.1 - 0.076 12.5 0.0 0.077 12.5 0.0 1.1 1 0 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) DcuC PF03606.15 KII72515.1 - 0.0083 14.6 3.2 0.013 14.0 3.2 1.2 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier RRM_1 PF00076.22 KII72516.1 - 1.2e-12 47.5 0.1 2.4e-12 46.5 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KII72516.1 - 0.0018 17.9 0.2 0.0034 17.0 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KII72516.1 - 0.0024 17.9 0.6 0.014 15.5 0.4 2.2 1 1 1 2 2 2 1 RNA recognition motif PDZ PF00595.24 KII72517.1 - 1.2e-09 38.4 0.7 1.9e-09 37.7 0.7 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII72517.1 - 1.2e-05 25.1 0.0 1.9e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_4 PF17816.1 KII72517.1 - 0.059 13.8 0.2 0.37 11.2 0.1 2.2 2 0 0 2 2 2 0 PDZ domain PDZ_2 PF13180.6 KII72517.1 - 0.065 13.6 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 PDZ domain BB_PF PF18063.1 KII72519.1 - 0.00054 19.6 0.4 0.00054 19.6 0.4 1.7 2 0 0 2 2 2 1 Beta barrel Pore-forming domain MLVIN_C PF18697.1 KII72520.1 - 0.00025 21.1 0.0 0.00042 20.4 0.0 1.4 1 1 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain ATG11 PF10377.9 KII72520.1 - 0.042 13.9 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 11 CLIP_SPH_mas PF18398.1 KII72524.1 - 0.36 11.3 0.2 0.36 11.3 0.2 1.9 2 0 0 2 2 2 0 Clip-domain serine protease homolog masquerade zf-Sec23_Sec24 PF04810.15 KII72526.1 - 0.086 12.9 2.6 0.19 11.8 0.2 2.7 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-H2C2_2 PF13465.6 KII72527.1 - 4.9e-13 48.9 22.0 4.6e-08 33.1 0.5 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 KII72527.1 - 5.7e-13 48.6 23.1 1.6e-05 25.1 3.4 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII72527.1 - 1.8e-09 37.6 18.4 0.00056 20.5 2.3 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KII72527.1 - 1.3e-05 25.3 5.9 0.013 15.8 0.2 3.6 3 1 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KII72527.1 - 5.3e-05 23.5 6.4 0.00025 21.3 0.3 3.8 3 1 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KII72527.1 - 0.00022 21.1 12.8 0.0038 17.2 1.9 3.6 3 1 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KII72527.1 - 0.022 14.5 0.4 0.022 14.5 0.4 4.0 4 1 0 4 4 4 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 KII72527.1 - 0.03 14.6 5.4 0.051 13.9 2.4 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF2387 PF09526.10 KII72527.1 - 0.18 12.0 2.5 0.41 10.8 2.5 1.6 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) zf-BED PF02892.15 KII72527.1 - 2.1 8.5 8.2 5.8 7.0 2.1 2.9 1 1 2 3 3 3 0 BED zinc finger zf-C2HE PF16278.5 KII72527.1 - 3 8.3 8.7 2.8e+02 2.1 8.7 2.9 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Ribosomal_L30 PF00327.20 KII72529.1 - 3.9e-10 39.5 0.8 7.1e-10 38.6 0.8 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Pyr_redox_3 PF13738.6 KII72529.1 - 0.037 13.3 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pro_isomerase PF00160.21 KII72530.1 - 5.3e-41 140.5 0.0 6.7e-41 140.2 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_M16_C PF05193.21 KII72531.1 - 3.2e-13 50.1 0.6 6.1e-12 45.9 0.2 2.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KII72531.1 - 3.8e-12 46.4 0.0 7.1e-10 39.0 0.0 2.8 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) Snapin_Pallidin PF14712.6 KII72532.1 - 0.0097 16.3 9.7 0.042 14.3 0.2 2.8 2 1 0 2 2 2 1 Snapin/Pallidin DUF5089 PF17002.5 KII72532.1 - 0.16 11.9 17.9 3.3 7.6 17.9 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5089) DUF745 PF05335.13 KII72532.1 - 0.33 10.7 12.4 0.46 10.2 3.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) ALMT PF11744.8 KII72532.1 - 0.34 9.7 8.2 0.76 8.5 8.2 1.5 1 1 0 1 1 1 0 Aluminium activated malate transporter V-SNARE_C PF12352.8 KII72532.1 - 0.41 11.0 5.3 0.47 10.8 1.3 2.7 2 1 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KII72532.1 - 0.48 10.4 3.1 4.6 7.2 0.3 2.4 2 1 0 2 2 2 0 Sec20 UPF0242 PF06785.11 KII72532.1 - 0.93 9.6 15.9 2.1 8.4 2.3 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Muted PF14942.6 KII72532.1 - 1.5 9.1 13.8 0.56 10.5 1.4 2.3 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein Mod_r PF07200.13 KII72532.1 - 2 8.5 14.8 1.3 9.1 1.1 2.4 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF4140 PF13600.6 KII72532.1 - 3.7 8.1 10.6 0.55 10.7 3.1 2.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) CREPT PF16566.5 KII72532.1 - 5.2 7.2 11.8 1.4 9.1 3.2 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour YtxH PF12732.7 KII72532.1 - 6.2 7.4 8.6 5.4 7.6 1.0 2.9 2 1 0 2 2 2 0 YtxH-like protein DUF16 PF01519.16 KII72532.1 - 7.3 7.1 12.0 0.72 10.4 2.3 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 Pox_P21 PF05313.12 KII72533.1 - 0.02 14.5 0.8 0.026 14.1 0.8 1.1 1 0 0 1 1 1 0 Poxvirus P21 membrane protein Integrin_beta PF00362.18 KII72534.1 - 0.06 13.0 0.0 0.083 12.5 0.0 1.1 1 0 0 1 1 1 0 Integrin beta chain VWA domain TssR PF17643.1 KII72534.1 - 0.14 10.1 0.0 0.17 9.8 0.0 1.0 1 0 0 1 1 1 0 Type VI secretion system, TssR STOP PF05217.12 KII72535.1 - 0.022 15.1 3.7 0.022 15.1 3.7 4.7 4 0 0 4 4 4 0 STOP protein EGF_2 PF07974.13 KII72535.1 - 0.64 10.4 75.3 0.068 13.5 14.0 5.1 3 1 1 4 4 4 0 EGF-like domain SNAP PF14938.6 KII72536.1 - 3.2e-06 26.8 0.3 4.3e-06 26.4 0.3 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Ldi PF18566.1 KII72536.1 - 0.033 13.7 0.1 0.045 13.2 0.1 1.2 1 0 0 1 1 1 0 Linalool dehydratase/isomerase TPR_8 PF13181.6 KII72536.1 - 0.44 10.9 2.5 49 4.5 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII72536.1 - 0.97 9.7 4.9 41 4.6 0.1 3.6 3 1 2 5 5 5 0 Tetratricopeptide repeat DDE_Tnp_IS1595 PF12762.7 KII72540.1 - 1.2e-05 25.4 0.1 0.0002 21.4 0.1 2.2 1 1 0 1 1 1 1 ISXO2-like transposase domain SNAP PF14938.6 KII72541.1 - 1.6e-12 47.5 4.2 1.9e-12 47.2 4.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RuBisCO_small PF00101.20 KII72541.1 - 0.019 15.0 0.1 0.18 11.8 0.0 2.3 2 0 0 2 2 2 0 Ribulose bisphosphate carboxylase, small chain SMG1 PF15785.5 KII72541.1 - 0.023 13.1 0.4 0.028 12.8 0.4 1.0 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 TPR_8 PF13181.6 KII72541.1 - 0.052 13.8 8.8 1.3 9.4 0.3 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat CBM_10 PF02013.16 KII72541.1 - 0.063 13.8 2.4 7.3 7.2 0.1 2.5 2 0 0 2 2 2 0 Cellulose or protein binding domain TPR_7 PF13176.6 KII72541.1 - 0.11 12.5 2.5 8.2 6.7 0.1 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF2786 PF10979.8 KII72541.1 - 0.45 10.5 7.0 5.3 7.0 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) TPR_2 PF07719.17 KII72541.1 - 1.6 9.0 11.0 0.41 10.9 2.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat RVP PF00077.20 KII72542.1 - 0.0097 16.2 0.0 0.028 14.7 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII72542.1 - 0.0099 16.4 0.0 0.075 13.6 0.0 2.4 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease EGF_2 PF07974.13 KII72543.1 - 9.9e-08 32.2 36.1 9.6e-05 22.7 16.3 2.8 2 0 0 2 2 2 2 EGF-like domain EGF_Tenascin PF18720.1 KII72543.1 - 3.8e-05 23.6 24.9 0.0014 18.7 10.8 2.6 2 0 0 2 2 2 2 Tenascin EGF domain I-EGF_1 PF18372.1 KII72543.1 - 6.3e-05 23.0 24.0 0.018 15.2 10.6 2.7 2 0 0 2 2 2 2 Integrin beta epidermal growth factor like domain 1 STOP PF05217.12 KII72543.1 - 0.0031 17.8 22.0 0.11 12.8 7.6 2.9 2 0 0 2 2 2 2 STOP protein Integrin_beta PF00362.18 KII72544.1 - 7.7e-08 32.3 0.0 4.9e-05 23.1 0.0 2.2 1 1 1 2 2 2 2 Integrin beta chain VWA domain PSI PF01437.25 KII72544.1 - 0.024 15.2 0.6 0.044 14.3 0.6 1.4 1 0 0 1 1 1 0 Plexin repeat PSI_integrin PF17205.3 KII72544.1 - 0.06 13.1 1.0 0.11 12.2 1.0 1.5 1 0 0 1 1 1 0 Integrin plexin domain EGF_2 PF07974.13 KII72546.1 - 4e-06 27.1 61.8 0.0033 17.8 11.9 4.1 4 0 0 4 4 4 3 EGF-like domain STOP PF05217.12 KII72546.1 - 0.019 15.3 41.5 0.3 11.4 5.3 4.7 4 0 0 4 4 4 0 STOP protein I-EGF_1 PF18372.1 KII72546.1 - 0.039 14.0 6.8 0.039 14.0 6.8 4.0 4 0 0 4 4 4 0 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 KII72546.1 - 1.2 9.2 39.9 0.13 12.3 8.9 3.6 3 0 0 3 3 3 0 Tenascin EGF domain Integrase_H2C2 PF17921.1 KII72548.1 - 0.0021 18.1 0.6 0.0047 17.0 0.6 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII72548.1 - 0.0025 18.0 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF3367 PF11847.8 KII72551.1 - 0.079 10.8 0.0 0.11 10.4 0.0 1.1 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase LGFP PF08310.11 KII72553.1 - 4.9e-05 23.8 11.5 35 5.0 0.1 6.9 1 1 7 8 8 8 3 LGFP repeat VirArc_Nuclease PF12187.8 KII72553.1 - 0.0002 21.0 1.4 46 3.5 0.0 5.3 1 1 7 8 8 8 0 Viral/Archaeal nuclease DUF1989 PF09347.10 KII72553.1 - 0.00072 19.2 5.7 8.4 6.0 0.2 3.9 1 1 5 6 6 6 6 Domain of unknown function (DUF1989) EbsA PF17255.2 KII72553.1 - 0.0013 19.1 8.9 2.1 8.7 0.2 3.4 1 1 4 5 5 5 5 EbsA-like protein NosD PF05048.13 KII72553.1 - 0.0041 16.4 0.1 0.0092 15.3 0.1 1.6 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Cnd1 PF12717.7 KII72554.1 - 0.0011 19.1 0.8 0.0017 18.4 0.8 1.2 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 SRP54_N PF02881.19 KII72554.1 - 0.019 15.2 0.3 0.039 14.2 0.3 1.5 1 0 0 1 1 1 0 SRP54-type protein, helical bundle domain Dynein_attach_N PF15867.5 KII72554.1 - 0.49 10.4 0.1 0.49 10.4 0.1 2.6 3 0 0 3 3 3 0 Dynein attachment factor N-terminus RT_RNaseH PF17917.1 KII72556.1 - 7.4e-37 125.8 0.1 2.4e-36 124.2 0.1 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72556.1 - 5.7e-35 119.4 0.2 2.5e-34 117.3 0.0 2.3 3 0 0 3 3 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72556.1 - 7.9e-27 94.2 0.1 2e-26 92.9 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72556.1 - 5.9e-25 87.8 0.0 2.3e-24 85.9 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72556.1 - 2.3e-17 62.8 0.2 1e-16 60.8 0.2 2.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 KII72556.1 - 6.3e-06 26.0 11.2 0.0024 17.9 2.0 2.7 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII72556.1 - 3.8e-05 23.9 0.0 0.00019 21.7 0.0 2.1 2 0 0 2 2 2 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII72556.1 - 0.00035 21.2 0.0 0.00086 19.9 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII72556.1 - 0.00044 20.7 0.0 0.001 19.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII72556.1 - 0.0014 18.4 0.1 0.0037 17.1 0.1 1.7 1 1 0 1 1 1 1 Aspartyl protease rve_3 PF13683.6 KII72556.1 - 0.0033 17.1 0.0 0.011 15.5 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain RVP_2 PF08284.11 KII72556.1 - 0.0056 16.5 0.3 0.012 15.4 0.3 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC_3 PF13917.6 KII72556.1 - 0.0097 15.9 5.9 0.025 14.6 0.5 2.5 1 1 1 2 2 2 1 Zinc knuckle zf-H2C2 PF09337.10 KII72556.1 - 0.086 13.1 0.8 0.36 11.1 0.1 2.5 2 0 0 2 2 2 0 H2C2 zinc finger Herpes_UL14 PF03580.14 KII72556.1 - 0.092 13.0 0.8 0.17 12.1 0.0 1.8 2 0 0 2 2 1 0 Herpesvirus UL14-like protein Peptidase_A2B PF12384.8 KII72556.1 - 0.12 11.9 0.0 0.61 9.6 0.0 2.0 1 1 0 2 2 2 0 Ty3 transposon peptidase Zn_Tnp_IS91 PF14319.6 KII72556.1 - 0.56 10.3 7.9 0.38 10.8 3.7 2.9 2 0 0 2 2 2 0 Transposase zinc-binding domain PHD_4 PF16866.5 KII72556.1 - 8.1 6.6 7.3 1.3 9.2 1.3 2.8 3 1 1 4 4 4 0 PHD-finger rve PF00665.26 KII72557.1 - 1.3e-14 54.4 0.0 3.2e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 KII72557.1 - 0.00046 19.8 0.1 0.25 10.8 0.0 2.7 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII72557.1 - 0.0053 16.8 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 KII72557.1 - 0.071 12.9 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Baculo_PEP_C PF04513.12 KII72558.1 - 9.8e-06 25.7 0.9 1.3e-05 25.3 0.9 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF713 PF05218.14 KII72558.1 - 0.1 12.3 5.4 0.23 11.2 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF713) FANCI_S4 PF14678.6 KII72558.1 - 0.43 9.7 4.5 4.2 6.4 0.3 2.1 1 1 1 2 2 2 0 FANCI solenoid 4 MSG PF02349.15 KII72558.1 - 1.8 8.8 7.7 47 4.3 7.7 2.4 1 1 0 1 1 1 0 Major surface glycoprotein Integrase_H2C2 PF17921.1 KII72559.1 - 0.0024 17.9 0.2 0.0043 17.1 0.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain SOCS_box PF07525.16 KII72559.1 - 0.13 12.6 0.1 0.92 9.9 0.1 2.2 2 0 0 2 2 2 0 SOCS box Ldl_recept_a PF00057.18 KII72560.1 - 5.8e-12 45.6 28.4 1.9e-07 31.2 8.2 3.5 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Kelch_1 PF01344.25 KII72561.1 - 2.8e-16 58.8 22.3 5.8e-06 25.8 0.1 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII72561.1 - 1e-15 57.5 12.8 0.00037 20.4 0.0 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 KII72561.1 - 4.1e-15 55.5 21.3 2.2e-06 27.8 0.4 6.8 6 2 1 7 7 7 3 Kelch motif Kelch_3 PF13415.6 KII72561.1 - 2.3e-11 43.7 10.4 0.035 14.4 0.0 6.9 6 1 1 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII72561.1 - 3.6e-10 39.6 20.2 0.0016 18.4 1.5 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 KII72561.1 - 3e-05 23.8 15.7 0.015 15.3 0.1 5.4 6 0 0 6 6 6 2 Kelch motif NPR2 PF06218.11 KII72564.1 - 0.09 11.5 1.0 0.091 11.5 1.0 1.1 1 0 0 1 1 1 0 Nitrogen permease regulator 2 RT_RNaseH PF17917.1 KII72565.1 - 1.5e-36 124.8 0.1 5.9e-36 122.9 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72565.1 - 7.9e-35 118.9 0.0 2.5e-34 117.3 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72565.1 - 9.8e-34 116.8 0.0 2.1e-33 115.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72565.1 - 3.2e-24 85.4 0.0 6.5e-24 84.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72565.1 - 2.4e-20 72.4 0.4 8.4e-20 70.6 0.4 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain MLVIN_C PF18697.1 KII72565.1 - 0.00012 22.1 0.1 0.016 15.3 0.0 3.1 3 0 0 3 3 3 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain zf-H2C2 PF09337.10 KII72565.1 - 0.00091 19.4 0.2 0.0045 17.2 0.0 2.3 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII72565.1 - 0.0076 16.0 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS1595 PF12762.7 KII72566.1 - 8.4e-15 55.1 0.0 1.7e-14 54.1 0.0 1.5 1 1 0 1 1 1 1 ISXO2-like transposase domain Arm-DNA-bind_2 PF12167.8 KII72566.1 - 0.17 11.8 0.6 0.77 9.7 0.0 2.4 2 0 0 2 2 2 0 Arm DNA-binding domain UvrB_inter PF17757.1 KII72567.1 - 0.00067 19.8 0.1 0.018 15.2 0.0 3.1 4 0 0 4 4 4 1 UvrB interaction domain Peptidase_C2 PF00648.21 KII72569.1 - 0.089 11.8 0.6 0.11 11.6 0.6 1.1 1 0 0 1 1 1 0 Calpain family cysteine protease Ldl_recept_a PF00057.18 KII72571.1 - 5.2e-25 87.4 96.2 2.9e-09 37.0 10.5 6.5 6 0 0 6 6 6 6 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII72574.1 - 5.7e-15 56.1 5.4 1e-14 55.2 5.4 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72574.1 - 6.4e-13 48.3 6.1 1.4e-12 47.2 6.1 1.6 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, UCH_N PF16674.5 KII72574.1 - 0.026 14.5 1.7 0.14 12.1 0.1 3.0 3 0 0 3 3 3 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 BNR PF02012.20 KII72574.1 - 0.15 12.2 4.4 0.52 10.5 0.4 3.4 3 0 0 3 3 3 0 BNR/Asp-box repeat DUF3652 PF12372.8 KII72577.1 - 0.033 14.1 0.1 0.057 13.3 0.1 1.3 1 0 0 1 1 1 0 Huntingtin protein region FERM_M PF00373.18 KII72579.1 - 5.1e-05 23.7 0.0 0.00022 21.6 0.0 2.1 2 1 0 2 2 2 1 FERM central domain BRCT_2 PF16589.5 KII72580.1 - 3.5e-05 24.1 0.1 0.0001 22.7 0.0 1.8 2 1 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain Pescadillo_N PF06732.11 KII72581.1 - 3.9e-51 174.2 3.5 6.8e-51 173.4 3.5 1.4 1 1 0 1 1 1 1 Pescadillo N-terminus MCM PF00493.23 KII72582.1 - 3.6e-100 333.7 0.1 1.1e-99 332.1 0.0 1.7 2 0 0 2 2 2 1 MCM P-loop domain MCM_lid PF17855.1 KII72582.1 - 4.7e-21 75.0 0.5 8.5e-21 74.2 0.5 1.4 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 KII72582.1 - 4.8e-15 55.5 0.0 8.7e-15 54.7 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 KII72582.1 - 1.5e-09 37.5 0.0 8.6e-06 25.3 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KII72582.1 - 1.3e-07 31.7 0.0 4.1e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KII72582.1 - 0.0029 17.5 0.0 0.0063 16.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KII72582.1 - 0.026 14.2 0.0 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase_C PF13335.6 KII72582.1 - 0.1 13.3 0.4 0.48 11.1 0.2 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal AAA_16 PF13191.6 KII72582.1 - 0.11 12.9 0.1 0.75 10.2 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain Regulator_TrmB PF11495.8 KII72583.1 - 0.0072 15.5 0.2 0.026 13.7 0.0 1.9 2 0 0 2 2 2 1 Archaeal transcriptional regulator TrmB MH2 PF03166.14 KII72584.1 - 1.9e-30 106.5 0.6 3.1e-30 105.8 0.6 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 KII72584.1 - 2.8e-30 104.6 0.0 4.8e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 MH1 domain MULE PF10551.9 KII72585.1 - 3.7e-14 52.9 0.0 8.3e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain I_LWEQ PF01608.17 KII72586.1 - 8.1e-38 130.1 4.0 8.1e-38 130.1 4.0 9.5 7 4 5 12 12 12 2 I/LWEQ domain FERM_M PF00373.18 KII72586.1 - 6.2e-08 33.1 0.4 6.2e-08 33.1 0.4 4.1 4 0 0 4 4 4 1 FERM central domain VBS PF08913.10 KII72586.1 - 1.6e-06 28.6 9.4 7.9e-05 23.1 1.3 5.6 5 0 0 5 5 5 1 Vinculin Binding Site DUF3053 PF11254.8 KII72586.1 - 0.0016 18.0 0.0 0.0016 18.0 0.0 5.5 6 0 0 6 6 6 1 Protein of unknown function (DUF3053) UPF0203 PF05254.12 KII72586.1 - 0.005 17.1 0.8 0.024 14.9 0.8 2.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) DUF4709 PF15821.5 KII72586.1 - 0.079 13.2 18.0 0.098 13.0 0.0 6.8 5 1 1 6 6 6 0 Domain of unknown function (DUF4709) MEIOC PF15189.6 KII72586.1 - 0.11 12.2 3.7 4.7 6.8 0.0 3.7 2 0 0 2 2 2 0 Meiosis-specific coiled-coil domain-containing protein MEIOC RabGAP-TBC PF00566.18 KII72586.1 - 0.11 12.2 6.2 0.11 12.1 1.2 3.4 3 0 0 3 3 3 0 Rab-GTPase-TBC domain DUF2935 PF11155.8 KII72586.1 - 0.76 10.1 16.2 2.3 8.6 0.0 7.1 7 2 1 8 8 8 0 Domain of unknown function (DUF2935) PI3_PI4_kinase PF00454.27 KII72588.1 - 1.6e-42 146.1 0.0 1.4e-29 103.7 0.0 2.1 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase SUKH-3 PF14433.6 KII72588.1 - 0.081 13.4 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 SUKH-3 immunity protein Alba PF01918.21 KII72589.1 - 0.00039 20.2 0.8 0.00077 19.2 0.1 1.8 2 1 1 3 3 3 1 Alba Rpp20 PF12328.8 KII72589.1 - 0.11 12.4 0.2 1.8 8.5 0.1 2.1 1 1 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P TPR_1 PF00515.28 KII72590.1 - 1.9e-09 36.9 5.0 0.0046 16.7 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KII72590.1 - 3.1e-09 36.3 4.8 0.04 14.0 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII72590.1 - 5.1e-08 32.5 1.7 0.15 12.4 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 KII72590.1 - 9.8e-07 28.4 0.3 0.0068 16.1 0.0 3.4 3 0 0 3 3 3 2 TPR repeat TPR_17 PF13431.6 KII72590.1 - 5.9e-06 26.3 0.4 0.013 15.9 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KII72590.1 - 6.6e-06 26.7 0.2 0.031 14.9 1.2 3.0 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KII72590.1 - 3.6e-05 24.2 0.1 0.48 11.0 0.4 3.5 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KII72590.1 - 7.1e-05 23.3 0.1 0.029 15.2 0.0 3.8 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 KII72590.1 - 0.00051 19.9 0.8 16 5.8 0.0 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 KII72590.1 - 0.0045 17.3 0.9 1.7 9.0 0.0 3.7 3 2 1 4 4 4 1 Tetratricopeptide repeat RPN7 PF10602.9 KII72590.1 - 0.033 13.9 0.4 0.25 11.0 0.1 2.5 3 1 0 3 3 3 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 KII72590.1 - 0.062 13.5 2.2 2.9 8.2 0.1 3.0 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 KII72590.1 - 0.14 12.3 0.0 4.2 7.6 0.0 3.0 2 1 2 4 4 4 0 Tetratricopeptide repeat Tox-REase-9 PF15650.6 KII72591.1 - 0.13 12.5 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 9 TPR_1 PF00515.28 KII72592.1 - 2.1e-09 36.8 8.6 0.0054 16.5 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KII72592.1 - 6e-08 32.2 8.6 0.013 15.5 0.6 5.1 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 KII72592.1 - 1.1e-05 25.4 0.0 0.00021 21.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KII72592.1 - 0.00049 20.3 0.4 0.0021 18.3 0.4 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 KII72592.1 - 0.0009 18.9 7.8 0.0034 17.0 0.4 3.8 3 1 1 4 4 4 1 TPR repeat TPR_8 PF13181.6 KII72592.1 - 0.0012 18.9 7.1 1.4 9.3 0.2 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KII72592.1 - 0.0019 18.4 0.9 0.044 14.1 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 KII72592.1 - 0.0027 18.2 5.8 0.0087 16.6 0.4 4.0 5 0 0 5 5 3 1 Tetratricopeptide repeat HU-DNA_bdg PF14848.6 KII72592.1 - 0.025 14.6 0.6 0.072 13.1 0.6 1.8 1 0 0 1 1 1 0 DNA-binding domain TPR_19 PF14559.6 KII72592.1 - 0.03 14.8 2.1 0.13 12.8 1.7 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KII72592.1 - 0.046 13.8 10.0 0.77 9.9 1.9 4.2 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 KII72592.1 - 0.05 13.1 0.1 0.14 11.7 0.1 1.8 1 0 0 1 1 1 0 SHNi-TPR MIT PF04212.18 KII72592.1 - 0.07 13.2 9.0 1.6 8.8 0.7 4.2 3 1 2 5 5 3 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 KII72592.1 - 0.098 12.9 8.6 0.24 11.6 5.1 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 VPS9 PF02204.18 KII72592.1 - 0.098 12.9 1.5 1.1 9.5 0.2 3.1 2 0 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain Histidinol_dh PF00815.20 KII72592.1 - 0.24 10.4 0.3 0.39 9.7 0.3 1.2 1 0 0 1 1 1 0 Histidinol dehydrogenase TPR_20 PF14561.6 KII72592.1 - 0.25 11.7 1.3 1.3 9.4 0.1 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat AAA_10 PF12846.7 KII72592.1 - 0.26 10.2 3.8 0.088 11.7 0.6 1.8 2 0 0 2 2 2 0 AAA-like domain Ras PF00071.22 KII72593.1 - 3.8e-49 166.4 0.8 4.7e-49 166.1 0.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII72593.1 - 7.3e-20 71.4 0.2 2e-19 70.0 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII72593.1 - 7.5e-11 41.8 0.0 9.7e-11 41.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KII72593.1 - 7.7e-07 28.8 0.2 3.9e-06 26.5 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 KII72593.1 - 4.5e-06 26.6 0.2 4.5e-06 26.6 0.2 1.7 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 KII72593.1 - 6.6e-06 26.2 0.2 3e-05 24.0 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KII72593.1 - 0.00017 21.6 2.5 0.027 14.4 0.2 2.2 1 1 1 2 2 2 2 RsgA GTPase NB-ARC PF00931.22 KII72593.1 - 0.0051 16.0 0.0 0.0094 15.2 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Vps52 PF04129.12 KII72593.1 - 0.015 14.0 0.6 0.025 13.3 0.6 1.3 1 0 0 1 1 1 0 Vps52 / Sac2 family ATPase_2 PF01637.18 KII72593.1 - 0.02 14.8 3.0 0.026 14.4 1.7 1.7 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 KII72593.1 - 0.04 14.2 0.1 0.3 11.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KII72593.1 - 0.049 13.2 0.0 0.74 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF188 PF02639.14 KII72593.1 - 0.056 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 TrmE_N PF10396.9 KII72593.1 - 0.074 13.4 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 GTP-binding protein TrmE N-terminus AlkA_N PF06029.11 KII72593.1 - 0.092 13.0 0.0 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 AlkA N-terminal domain ArsD PF06953.11 KII72593.1 - 0.1 13.0 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Arsenical resistance operon trans-acting repressor ArsD AAA_16 PF13191.6 KII72593.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 KII72593.1 - 0.21 11.3 3.7 4.4 7.0 0.2 2.5 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 KII72594.1 - 2.3e-68 230.4 0.2 2.8e-68 230.1 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII72594.1 - 1.2e-36 126.4 0.0 1.3e-36 126.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII72594.1 - 6.1e-07 29.0 0.0 1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KII72594.1 - 1.1e-05 24.9 0.1 1.7e-05 24.3 0.1 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII72594.1 - 1.7e-05 24.9 0.3 8.2e-05 22.6 0.3 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 KII72594.1 - 2.9e-05 23.8 0.2 3.8e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 KII72594.1 - 0.00034 19.7 0.6 0.00066 18.7 0.6 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 KII72594.1 - 0.0044 16.6 1.4 0.0095 15.5 1.4 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase FTA2 PF13095.6 KII72594.1 - 0.011 15.4 0.1 0.02 14.5 0.1 1.5 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-PolyVal PF18762.1 KII72594.1 - 0.029 14.3 0.2 0.046 13.7 0.2 1.4 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins YrbL-PhoP_reg PF10707.9 KII72594.1 - 0.13 11.8 1.1 0.42 10.1 1.1 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Ribosomal_S18 PF01084.20 KII72595.1 - 1.8e-07 31.3 0.0 4e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S18 DUF908 PF06012.12 KII72596.1 - 0.0069 15.8 1.9 0.0067 15.9 1.9 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) YL1 PF05764.13 KII72596.1 - 0.035 14.2 10.2 0.041 14.0 10.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein PGA2 PF07543.12 KII72596.1 - 0.67 9.9 8.7 0.91 9.5 8.7 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 Presenilin PF01080.17 KII72596.1 - 0.89 8.3 3.6 0.86 8.3 3.6 1.1 1 0 0 1 1 1 0 Presenilin SspB PF04386.13 KII72596.1 - 1.1 9.2 5.6 1.6 8.6 5.6 1.2 1 0 0 1 1 1 0 Stringent starvation protein B UCMA PF17085.5 KII72596.1 - 7.4 6.6 14.0 0.46 10.5 5.8 2.2 1 1 1 2 2 2 0 Unique cartilage matrix associated protein Ribosomal_L28e PF01778.17 KII72597.1 - 5.6e-14 52.9 2.7 5.6e-14 52.9 2.7 1.6 1 1 0 1 1 1 1 Ribosomal L28e protein family YvbH_ext PF11724.8 KII72597.1 - 0.13 12.6 0.1 2.8 8.3 0.1 2.2 2 0 0 2 2 2 0 YvbH-like oligomerisation region zf-TRM13_CCCH PF11722.8 KII72598.1 - 0.099 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 CCCH zinc finger in TRM13 protein RT_RNaseH_2 PF17919.1 KII72602.1 - 5.7e-34 116.1 0.0 1.4e-33 114.8 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72602.1 - 1.8e-32 111.8 0.0 5.4e-32 110.2 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72602.1 - 6e-21 75.0 0.0 1.2e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72602.1 - 7.7e-20 71.3 0.0 3.6e-19 69.1 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72602.1 - 1.7e-17 63.2 0.0 4.5e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII72602.1 - 1.2e-06 29.0 0.0 2.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII72602.1 - 5.2e-05 23.8 0.0 0.00013 22.5 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII72602.1 - 0.00054 20.2 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease rve_3 PF13683.6 KII72602.1 - 0.0092 15.7 0.0 0.033 14.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain HypF_C PF17788.1 KII72602.1 - 0.13 13.0 0.0 1.2 9.8 0.0 2.4 2 0 0 2 2 2 0 HypF Kae1-like domain RBR PF17208.3 KII72603.1 - 0.02 15.6 0.4 0.047 14.4 0.4 1.6 1 0 0 1 1 1 0 RNA binding Region DUF4138 PF13595.6 KII72603.1 - 0.13 11.6 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) Ldl_recept_a PF00057.18 KII72604.1 - 0.00012 22.3 18.0 0.0017 18.6 9.1 2.8 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII72605.1 - 1e-31 108.8 68.0 4.4e-11 42.8 10.6 4.2 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII72607.1 - 6.4e-05 23.4 0.1 0.00011 22.6 0.1 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII72607.1 - 1.7 9.0 10.2 1.1 9.5 0.2 4.7 4 1 1 5 5 5 0 BNR/Asp-box repeat RVT_1 PF00078.27 KII72609.1 - 6.8e-14 51.9 0.1 4.8e-13 49.1 0.1 1.9 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII72610.1 - 6e-18 65.1 0.0 1.2e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII72610.1 - 7.4e-15 54.8 1.3 2.3e-14 53.2 1.3 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 KII72610.1 - 3.9e-12 46.1 0.0 8e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII72610.1 - 0.0046 17.1 0.0 0.0097 16.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII72610.1 - 0.26 11.5 3.0 0.18 12.0 0.9 1.8 2 0 0 2 2 2 0 H2C2 zinc finger Pox_T4_C PF04490.12 KII72611.1 - 0.057 13.6 0.1 0.061 13.5 0.1 1.1 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus NERD PF08378.11 KII72611.1 - 0.1 13.1 0.1 0.13 12.7 0.1 1.4 1 1 0 1 1 1 0 Nuclease-related domain Lyase_1 PF00206.20 KII72612.1 - 5.6e-21 75.2 0.0 7.4e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 Lyase DUF1929 PF09118.11 KII72612.1 - 0.18 12.1 0.1 32 4.9 0.1 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF1929) ADSL_C PF10397.9 KII72613.1 - 2.7e-09 37.4 0.0 3.6e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus PAF-AH_p_II PF03403.13 KII72613.1 - 0.019 13.5 0.1 0.024 13.1 0.1 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II TPR_22 PF18833.1 KII72613.1 - 0.087 13.0 0.1 5.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Sugar_tr PF00083.24 KII72616.1 - 1.6e-18 66.8 6.4 1.9e-18 66.6 6.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Tetraspanin PF00335.20 KII72617.1 - 6.7e-11 42.3 9.5 9.5e-11 41.8 9.5 1.2 1 0 0 1 1 1 1 Tetraspanin family GPI2 PF06432.11 KII72617.1 - 1.8 7.9 9.1 2.7 7.4 9.1 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase TraB PF01963.17 KII72619.1 - 0.00011 22.2 0.2 0.026 14.4 0.0 2.2 2 0 0 2 2 2 2 TraB family ATP-synt_ab_C PF00306.27 KII72620.1 - 0.0027 18.0 0.1 0.039 14.3 0.1 2.1 1 1 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain DUF4298 PF14131.6 KII72620.1 - 0.066 13.2 0.6 0.14 12.1 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) PLDc_2 PF13091.6 KII72621.1 - 4.5e-20 71.9 0.0 1.2e-13 51.1 0.0 2.1 2 0 0 2 2 2 2 PLD-like domain PLDc_3 PF13918.6 KII72621.1 - 2.1e-07 30.8 0.0 1.5e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 PLD-like domain PLDc PF00614.22 KII72621.1 - 1.8e-06 27.9 0.1 0.00086 19.4 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif NTS PF15447.6 KII72621.1 - 0.056 13.9 0.2 2.3 8.8 0.0 2.6 2 0 0 2 2 2 0 N-terminal segments of PfEMP1 DDE_3 PF13358.6 KII72622.1 - 1.7e-13 50.5 0.0 2.1e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease UDPGT PF00201.18 KII72622.1 - 0.0055 15.5 0.0 0.006 15.4 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase DDE_1 PF03184.19 KII72622.1 - 0.1 12.3 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease EMI PF07546.13 KII72623.1 - 0.016 16.0 1.4 0.021 15.5 1.4 1.2 1 0 0 1 1 1 0 EMI domain Peptidase_S9 PF00326.21 KII72625.1 - 8.9e-07 28.6 0.0 1e-06 28.4 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family RT_RNaseH PF17917.1 KII72627.1 - 1.2e-35 122.0 0.0 2.2e-35 121.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72627.1 - 6.7e-33 112.7 0.0 1.6e-32 111.5 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72627.1 - 3.4e-19 69.3 0.1 6.8e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII72628.1 - 5.4e-09 36.0 0.2 9.3e-09 35.3 0.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain PP-binding PF00550.25 KII72630.1 - 0.00013 22.2 0.1 0.00022 21.5 0.1 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site Lin0512_fam PF09585.10 KII72630.1 - 0.14 12.2 0.0 0.22 11.5 0.0 1.4 1 1 0 1 1 1 0 Conserved hypothetical protein (Lin0512_fam) LMWPc PF01451.21 KII72630.1 - 0.17 12.3 0.0 1 9.7 0.0 1.9 1 1 1 2 2 2 0 Low molecular weight phosphotyrosine protein phosphatase Shisa PF13908.6 KII72631.1 - 0.011 16.0 0.1 0.011 16.0 0.1 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DAG1 PF05454.11 KII72631.1 - 0.049 13.0 0.2 0.074 12.4 0.2 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) rve PF00665.26 KII72632.1 - 1.2e-19 70.6 0.1 1.8e-19 70.0 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72632.1 - 1.1e-16 60.6 0.3 2.6e-16 59.5 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII72632.1 - 9.3e-05 22.6 0.6 0.00022 21.4 0.1 1.9 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII72632.1 - 0.0005 19.8 0.0 0.0013 18.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII72632.1 - 0.052 13.3 0.0 0.093 12.5 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Nepo_coat_N PF03689.15 KII72632.1 - 0.061 13.3 0.1 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain OAD_gamma PF04277.13 KII72633.1 - 0.021 15.4 0.2 0.031 14.9 0.2 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Glycophorin_A PF01102.18 KII72633.1 - 0.099 12.9 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A DUF5530 PF17670.1 KII72635.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5530) MAPEG PF01124.18 KII72635.1 - 0.18 11.7 1.2 0.24 11.3 1.2 1.1 1 0 0 1 1 1 0 MAPEG family Plk4_PB1 PF18190.1 KII72637.1 - 0.17 12.1 1.3 0.33 11.2 0.1 2.0 2 1 0 2 2 2 0 Polo-like Kinase 4 Polo Box 1 WBP-1 PF11669.8 KII72643.1 - 0.07 13.8 0.0 0.092 13.4 0.0 1.2 1 0 0 1 1 1 0 WW domain-binding protein 1 WBP-1 PF11669.8 KII72644.1 - 0.0016 19.0 0.0 0.0021 18.7 0.0 1.1 1 0 0 1 1 1 1 WW domain-binding protein 1 Vpu PF00558.19 KII72644.1 - 0.031 14.1 0.0 0.039 13.7 0.0 1.1 1 0 0 1 1 1 0 Vpu protein MULE PF10551.9 KII72647.1 - 9.7e-07 29.1 0.2 2.5e-06 27.8 0.2 1.7 1 0 0 1 1 1 1 MULE transposase domain Mpp10 PF04006.12 KII72648.1 - 2.3e-12 46.2 8.0 2.3e-12 46.2 8.0 1.0 1 0 0 1 1 1 1 Mpp10 protein RNase_T PF00929.24 KII72651.1 - 2.9e-21 76.7 0.5 4.4e-20 72.9 0.1 2.6 2 1 0 2 2 2 1 Exonuclease zf-dskA_traR PF01258.17 KII72651.1 - 4.2e-10 39.4 3.2 8.6e-10 38.4 3.2 1.5 1 0 0 1 1 1 1 Prokaryotic dksA/traR C4-type zinc finger DUF5051 PF16473.5 KII72651.1 - 1.2e-06 28.6 0.2 2.6e-06 27.5 0.2 1.6 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like DNA_pol_A_exo1 PF01612.20 KII72651.1 - 8.2e-05 22.4 0.3 0.00048 19.9 0.3 2.2 1 1 0 1 1 1 1 3'-5' exonuclease DZR PF12773.7 KII72651.1 - 0.018 15.0 0.3 0.038 14.0 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf_UBZ PF18439.1 KII72651.1 - 0.32 10.6 0.1 0.32 10.6 0.1 2.0 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF5347 PF17282.2 KII72652.1 - 1.6e-42 143.9 0.1 1.9e-42 143.7 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5347) Gluconate_2-dh3 PF13618.6 KII72652.1 - 0.12 12.6 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 Phage_CP76 PF06892.11 KII72653.1 - 5.4e-59 198.2 0.6 6e-59 198.1 0.6 1.0 1 0 0 1 1 1 1 Phage regulatory protein CII (CP76) DDE_Tnp_IS240 PF13610.6 KII72653.1 - 0.065 13.5 0.0 0.086 13.1 0.0 1.2 1 0 0 1 1 1 0 DDE domain Phage_CI_C PF16452.5 KII72654.1 - 1.1e-28 99.5 0.0 1.8e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 Bacteriophage CI repressor C-terminal domain Phage_CI_repr PF07022.13 KII72654.1 - 2.6e-21 75.5 0.0 4.3e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain HTH_psq PF05225.16 KII72654.1 - 0.019 14.7 0.0 0.049 13.4 0.0 1.7 2 0 0 2 2 2 0 helix-turn-helix, Psq domain Sortilin-Vps10 PF15902.5 KII72656.1 - 0.0012 17.8 0.2 0.27 10.0 0.1 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72656.1 - 0.12 12.5 0.2 1.4 9.2 0.1 2.5 2 0 0 2 2 2 0 BNR/Asp-box repeat zf-CCHC_4 PF14392.6 KII72658.1 - 0.0012 18.6 9.2 0.022 14.5 2.1 2.7 2 0 0 2 2 2 2 Zinc knuckle Arrestin_C PF02752.22 KII72658.1 - 0.0051 17.3 0.2 0.027 14.9 0.0 2.1 1 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain zf-CCHC PF00098.23 KII72658.1 - 0.058 13.5 10.6 0.23 11.6 2.9 2.4 2 0 0 2 2 2 0 Zinc knuckle SipA PF09052.10 KII72658.1 - 0.064 12.9 0.5 0.12 11.9 0.5 1.4 1 0 0 1 1 1 0 SipA N-terminal domain Phage_portal PF04860.12 KII72658.1 - 0.13 11.4 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 Phage portal protein zf-CCHC_2 PF13696.6 KII72658.1 - 3.3 7.6 11.6 4.6 7.2 2.1 2.6 2 0 0 2 2 2 0 Zinc knuckle Pup PF05639.11 KII72659.1 - 0.16 12.9 1.0 18 6.3 0.0 2.8 3 0 0 3 3 3 0 Pup-like protein RVT_1 PF00078.27 KII72661.1 - 1.8e-18 66.9 0.0 2.2e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HNH_3 PF13392.6 KII72661.1 - 0.11 12.2 1.7 0.22 11.3 1.7 1.4 1 0 0 1 1 1 0 HNH endonuclease 23ISL PF16620.5 KII72661.1 - 0.14 12.3 0.1 0.24 11.6 0.1 1.3 1 0 0 1 1 1 0 Unstructured linker between I-set domains 2 and 3 on MYLCK rve PF00665.26 KII72662.1 - 1.8e-10 41.0 0.0 2.4e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII72662.1 - 7.8e-05 22.4 0.0 0.00011 21.9 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.6 KII72663.1 - 0.0018 18.9 0.0 0.0025 18.4 0.0 1.4 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII72663.1 - 0.022 15.3 0.0 0.031 14.8 0.0 1.6 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 KII72664.1 - 2.1e-09 37.3 0.0 2.6e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII72665.1 - 2.2e-08 34.3 0.1 3.1e-08 33.9 0.1 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72665.1 - 5.8e-06 26.3 0.2 9.4e-06 25.6 0.2 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Microcin PF03526.13 KII72665.1 - 0.021 14.6 0.3 0.036 13.9 0.3 1.3 1 0 0 1 1 1 0 Colicin E1 (microcin) immunity protein AT_hook PF02178.19 KII72667.1 - 3.3 7.9 9.5 0.22 11.5 1.4 2.7 2 0 0 2 2 2 0 AT hook motif Sortilin-Vps10 PF15902.5 KII72668.1 - 1.9e-06 26.9 0.0 3.8e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72668.1 - 0.0011 18.6 0.8 0.12 12.4 0.6 2.7 2 0 0 2 2 2 1 BNR/Asp-box repeat RT_RNaseH_2 PF17919.1 KII72669.1 - 8.5e-06 25.7 0.1 2.2e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72669.1 - 4e-05 23.8 0.1 0.059 13.7 0.0 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase rve_3 PF13683.6 KII72669.1 - 0.012 15.4 0.1 0.063 13.1 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain DUF448 PF04296.13 KII72670.1 - 0.026 14.4 0.1 0.12 12.2 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF448) E3_UFM1_ligase PF09743.9 KII72671.1 - 8.5e-16 58.4 0.1 1.1e-15 58.0 0.1 1.1 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 APOBEC4_like PF18774.1 KII72671.1 - 0.028 14.3 0.3 0.064 13.2 0.1 1.7 2 0 0 2 2 2 0 APOBEC4-like -AID/APOBEC-deaminase Sigma70_r1_1 PF03979.14 KII72673.1 - 0.11 12.5 1.7 2.6 8.2 0.0 2.9 3 0 0 3 3 3 0 Sigma-70 factor, region 1.1 U3_assoc_6 PF08640.11 KII72673.1 - 7.7 6.7 9.7 3.7 7.7 0.0 3.3 3 1 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 Dimer_Tnp_hAT PF05699.14 KII72674.1 - 0.00021 21.0 0.2 0.00034 20.3 0.2 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region SNAP PF14938.6 KII72675.1 - 6.6e-10 38.9 3.1 9.5e-10 38.4 3.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 KII72675.1 - 0.00018 21.2 15.0 0.019 14.8 0.1 4.9 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KII72675.1 - 0.00019 21.2 1.0 8.1 6.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KII72675.1 - 0.002 18.2 10.7 0.96 9.8 0.1 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat RPN7 PF10602.9 KII72675.1 - 0.023 14.4 4.7 9.3 5.9 0.8 3.7 1 1 1 2 2 2 0 26S proteasome subunit RPN7 TPR_12 PF13424.6 KII72675.1 - 0.03 14.6 0.5 5 7.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII72675.1 - 0.064 13.4 13.7 3.7 7.9 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR PF01535.20 KII72675.1 - 0.076 13.3 3.9 0.61 10.5 0.1 3.1 3 0 0 3 3 3 0 PPR repeat DUF2150 PF09920.9 KII72675.1 - 0.095 12.7 0.3 4.6 7.2 0.1 2.6 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2150) TPR_11 PF13414.6 KII72675.1 - 0.13 11.9 4.2 0.88 9.3 0.0 3.5 2 1 2 4 4 4 0 TPR repeat RNA_pol_N PF01194.17 KII72675.1 - 0.23 11.8 1.6 0.42 10.9 0.0 2.3 2 1 0 2 2 2 0 RNA polymerases N / 8 kDa subunit NSF PF02071.20 KII72675.1 - 3.2 8.9 11.0 10 7.4 0.3 4.3 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat SNAP PF14938.6 KII72676.1 - 8.4e-13 48.4 0.0 1.1e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII72676.1 - 0.0071 16.6 2.6 0.1 12.9 0.5 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KII72676.1 - 0.054 13.5 2.0 32 4.9 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF1796 PF08795.10 KII72676.1 - 0.14 12.1 0.2 0.24 11.3 0.2 1.3 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) TPR_8 PF13181.6 KII72676.1 - 0.21 11.9 7.0 19 5.8 0.1 4.8 3 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII72676.1 - 0.62 10.3 6.3 43 4.6 0.0 4.8 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII72676.1 - 1.5 8.8 8.8 6.7 6.7 0.0 5.1 6 1 1 7 7 7 0 Tetratricopeptide repeat Imm6 PF14434.6 KII72679.1 - 0.036 14.0 0.7 0.095 12.6 0.7 1.7 1 0 0 1 1 1 0 Immunity protein Imm6 Rep_fac_C PF08542.11 KII72680.1 - 1.2e-10 41.6 0.1 2.3e-10 40.8 0.0 1.4 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 KII72680.1 - 1.1e-05 25.6 0.0 2.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 AAA C-terminal domain Galactosyl_T PF01762.21 KII72682.1 - 2.1e-29 102.8 0.6 2.9e-29 102.3 0.6 1.2 1 0 0 1 1 1 1 Galactosyltransferase CHB_HEX PF03173.13 KII72682.1 - 0.11 12.1 0.1 0.19 11.4 0.1 1.2 1 0 0 1 1 1 0 Putative carbohydrate binding domain RT_RNaseH PF17917.1 KII72683.1 - 1.1e-37 128.5 0.5 1.2e-36 125.2 0.0 2.9 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72683.1 - 3.7e-37 126.4 1.1 2.9e-36 123.5 0.1 3.1 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72683.1 - 1.1e-31 110.1 0.8 2.6e-31 108.9 0.1 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72683.1 - 1.2e-21 77.2 0.0 3.3e-21 75.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72683.1 - 2.1e-19 69.4 0.3 5.9e-19 67.9 0.3 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII72683.1 - 0.00026 21.2 0.0 0.00074 19.7 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII72683.1 - 0.0017 18.1 0.1 0.0062 16.3 0.1 2.0 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 KII72683.1 - 0.0035 17.3 6.2 0.4 10.8 0.4 2.6 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII72683.1 - 0.0071 16.6 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 KII72683.1 - 0.013 15.3 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Retrotran_gag_2 PF14223.6 KII72683.1 - 0.049 13.3 0.3 26 4.5 0.0 3.5 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type zf-CCHC_3 PF13917.6 KII72683.1 - 6 6.9 7.3 5.4 7.1 0.4 2.6 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII72683.1 - 6.3 6.6 8.0 26 4.7 2.4 2.7 1 1 1 2 2 2 0 Zinc knuckle Galactosyl_T PF01762.21 KII72684.1 - 4.4e-28 98.4 0.1 6.6e-28 97.9 0.1 1.3 1 0 0 1 1 1 1 Galactosyltransferase Galactosyl_T PF01762.21 KII72686.1 - 6.1e-27 94.7 0.6 7.9e-27 94.3 0.6 1.2 1 0 0 1 1 1 1 Galactosyltransferase FLYWCH PF04500.16 KII72687.1 - 8.1e-09 35.5 1.8 1.3e-08 34.9 1.8 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain Mob_synth_C PF06463.13 KII72688.1 - 3.9e-27 94.7 0.0 4.3e-27 94.6 0.0 1.0 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C SPASM PF13186.6 KII72688.1 - 0.083 13.4 0.1 0.22 12.1 0.1 1.7 1 1 1 2 2 2 0 Iron-sulfur cluster-binding domain Tetraspanin PF00335.20 KII72689.1 - 7e-13 48.8 10.9 1.2e-12 48.1 10.9 1.4 1 1 0 1 1 1 1 Tetraspanin family Myco_arth_vir_N PF09610.10 KII72689.1 - 2.6 8.2 6.6 7.8 6.7 6.6 1.8 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Toxin_21 PF08091.11 KII72690.1 - 0.0098 15.8 0.5 0.017 15.0 0.5 1.3 1 0 0 1 1 1 1 Spider insecticidal peptide DDE_3 PF13358.6 KII72694.1 - 4.8e-23 81.5 0.0 8.7e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII72694.1 - 0.00018 21.7 0.2 0.00084 19.5 0.1 2.0 2 0 0 2 2 2 1 Transposase rve PF00665.26 KII72694.1 - 0.0058 16.8 0.0 0.019 15.1 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain DUF1582 PF07621.11 KII72694.1 - 0.097 12.6 0.2 5.7 7.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1582) HTH_Tnp_IS630 PF01710.16 KII72694.1 - 0.13 12.3 0.4 17 5.5 0.1 2.3 2 0 0 2 2 2 0 Transposase 2OG-FeII_Oxy_3 PF13640.6 KII72695.1 - 6.1e-11 43.1 0.0 1e-10 42.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PKD_channel PF08016.12 KII72695.1 - 0.13 10.9 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Polycystin cation channel P4Ha_N PF08336.11 KII72696.1 - 3.1e-17 62.9 0.0 4.9e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 KII72697.1 - 4.8e-11 43.4 0.1 1.5e-10 41.8 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily P4Ha_N PF08336.11 KII72697.1 - 2.2e-10 40.7 1.0 4.3e-10 39.7 0.1 1.9 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_2 PF07719.17 KII72697.1 - 6.4e-05 22.8 0.0 0.024 14.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KII72697.1 - 0.0012 18.8 0.0 0.0037 17.3 0.0 1.8 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat 2OG-FeII_Oxy PF03171.20 KII72697.1 - 0.0015 19.0 0.0 0.0038 17.7 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HTH_9 PF08221.11 KII72698.1 - 1.5e-07 31.4 0.6 0.002 18.2 0.1 2.3 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF4974 PF16344.5 KII72698.1 - 0.05 13.6 0.4 0.95 9.5 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4974) Costars PF14705.6 KII72698.1 - 0.058 13.6 0.0 9.9 6.4 0.0 2.5 2 1 0 2 2 2 0 Costars VF530 PF09905.9 KII72698.1 - 0.077 13.2 0.2 0.9 9.8 0.0 2.3 2 0 0 2 2 2 0 DNA-binding protein VF530 DnaJ PF00226.31 KII72700.1 - 1.4e-23 82.8 0.1 1.9e-23 82.4 0.1 1.2 1 0 0 1 1 1 1 DnaJ domain DUF4108 PF13390.6 KII72701.1 - 0.031 14.2 3.8 0.73 9.7 3.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4108) SKICH PF17751.1 KII72702.1 - 0.01 16.3 0.6 0.025 15.1 0.6 1.7 1 0 0 1 1 1 0 SKICH domain Trimer_CC PF08954.11 KII72702.1 - 0.026 14.1 0.1 0.23 11.1 0.2 2.1 2 0 0 2 2 2 0 Trimerisation motif Med30 PF11315.8 KII72702.1 - 0.043 14.0 2.1 0.063 13.5 1.2 1.7 1 1 0 1 1 1 0 Mediator complex subunit 30 Microtub_bind PF13931.6 KII72702.1 - 0.052 13.9 2.6 0.14 12.6 2.6 1.7 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding NinF PF05810.12 KII72702.1 - 0.088 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NinF protein UBZ_FAAP20 PF15750.5 KII72702.1 - 0.19 11.7 0.2 0.76 9.8 0.1 2.0 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Cyto_heme_lyase PF01265.17 KII72703.1 - 2.8e-52 178.1 10.6 1.9e-50 172.2 10.6 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase NAC PF01849.18 KII72704.1 - 2.2e-10 40.3 0.0 4.7e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 NAC domain DUF3135 PF11333.8 KII72704.1 - 0.06 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) AAA_lid_10 PF17872.1 KII72704.1 - 0.072 13.2 0.2 0.18 12.0 0.0 1.6 2 0 0 2 2 2 0 AAA lid domain Pro_isomerase PF00160.21 KII72705.1 - 1e-50 172.1 0.1 1.1e-50 171.9 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Sld7_N PF18636.1 KII72705.1 - 0.011 16.1 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain Thymosin PF01290.20 KII72707.1 - 5.8e-16 57.9 1.4 1e-15 57.1 1.4 1.4 1 0 0 1 1 1 1 Thymosin beta-4 family WH2 PF02205.20 KII72707.1 - 0.16 11.8 1.1 0.55 10.2 1.1 2.0 1 1 0 1 1 1 0 WH2 motif UAA PF08449.11 KII72708.1 - 2.3e-39 135.4 25.2 2.8e-39 135.1 25.2 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KII72708.1 - 4.2e-08 33.5 23.5 0.00013 22.2 4.9 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KII72708.1 - 2.4e-05 23.8 15.5 2.9e-05 23.6 15.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family Asp_protease PF09668.10 KII72711.1 - 1.6e-05 24.7 0.0 8.4e-05 22.4 0.0 2.1 2 1 0 2 2 2 1 Aspartyl protease RVP PF00077.20 KII72711.1 - 0.00043 20.5 0.0 0.0013 19.0 0.0 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease Retrotran_gag_2 PF14223.6 KII72711.1 - 0.00051 19.7 0.1 0.0012 18.6 0.0 1.6 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 KII72711.1 - 0.0028 17.7 1.2 0.0028 17.7 1.2 2.6 2 0 0 2 2 1 1 Zinc knuckle gag-asp_proteas PF13975.6 KII72711.1 - 0.014 15.9 0.0 0.053 14.1 0.0 2.0 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_3 PF13917.6 KII72711.1 - 0.02 14.9 14.7 0.24 11.4 1.3 2.7 1 1 1 2 2 2 0 Zinc knuckle DUF5082 PF16888.5 KII72711.1 - 0.029 14.7 0.0 0.72 10.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) RVT_1 PF00078.27 KII72711.1 - 0.16 11.5 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_Tnp_1 PF01527.20 KII72711.1 - 0.16 12.3 0.2 3.4 8.0 0.0 2.7 2 0 0 2 2 2 0 Transposase Asp_protease_2 PF13650.6 KII72711.1 - 0.17 12.6 0.0 1.7 9.3 0.0 2.5 1 1 0 1 1 1 0 Aspartyl protease DUF1192 PF06698.11 KII72711.1 - 0.17 12.0 1.9 1.3 9.1 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) zf-CCHC_4 PF14392.6 KII72711.1 - 8.3 6.2 12.6 2.9 7.7 0.7 2.7 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 KII72714.1 - 3.6e-17 62.6 0.0 7.1e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72714.1 - 5e-15 55.4 1.1 1.3e-14 54.0 1.1 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII72714.1 - 0.00044 20.0 0.1 0.001 18.8 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Retrotrans_gag PF03732.17 KII72715.1 - 0.0023 18.2 0.0 0.0051 17.1 0.0 1.6 2 0 0 2 2 2 1 Retrotransposon gag protein T_Ag_DNA_bind PF02217.16 KII72717.1 - 0.21 12.2 3.0 0.11 13.1 1.2 1.6 2 0 0 2 2 2 0 Origin of replication binding protein Clathrin-link PF09268.10 KII72718.1 - 0.083 12.3 0.2 0.16 11.4 0.2 1.5 1 0 0 1 1 1 0 Clathrin, heavy-chain linker DUF3828 PF12883.7 KII72718.1 - 0.085 13.2 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3828) Cu_amine_oxidN3 PF02728.16 KII72719.1 - 0.08 13.4 0.2 1.5 9.2 0.0 2.8 2 1 1 3 3 3 0 Copper amine oxidase, N3 domain Histone PF00125.24 KII72719.1 - 0.089 13.2 2.1 4.7 7.6 0.0 3.8 3 1 0 3 3 3 0 Core histone H2A/H2B/H3/H4 FeoB_associated PF12669.7 KII72720.1 - 0.051 14.0 0.7 0.1 13.0 0.7 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF1129 PF06570.11 KII72720.1 - 0.066 12.7 2.6 0.059 12.9 1.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Phage_SSB PF16773.5 KII72720.1 - 0.37 10.9 3.2 1.4 9.0 0.2 2.7 1 1 1 2 2 2 0 Lactococcus phage single-stranded DNA binding protein SdpI PF13630.6 KII72720.1 - 0.9 9.7 4.4 0.19 11.9 0.9 1.7 2 0 0 2 2 2 0 SdpI/YhfL protein family E1-E2_ATPase PF00122.20 KII72720.1 - 1 8.9 4.8 4.9 6.6 0.2 2.9 3 0 0 3 3 3 0 E1-E2 ATPase MscL PF01741.18 KII72721.1 - 0.026 14.8 0.5 0.052 13.8 0.5 1.7 1 1 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL rve PF00665.26 KII72728.1 - 1.2e-24 86.7 0.0 2e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72728.1 - 9.1e-21 73.7 0.4 3.2e-20 72.0 0.4 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII72728.1 - 0.00018 21.6 0.2 0.0018 18.4 0.0 2.7 2 0 0 2 2 2 1 H2C2 zinc finger MLVIN_C PF18697.1 KII72728.1 - 0.0027 17.7 0.5 0.0067 16.5 0.0 1.9 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII72728.1 - 0.003 17.3 0.0 0.0073 16.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Ldl_recept_a PF00057.18 KII72730.1 - 2.3e-07 30.9 10.0 2.3e-07 30.9 10.0 2.8 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A RT_RNaseH_2 PF17919.1 KII72731.1 - 3.2e-30 104.1 0.2 7.7e-30 102.9 0.2 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72731.1 - 9.1e-21 74.1 0.1 2e-20 73.0 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72731.1 - 2e-19 70.0 0.0 4.5e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII72731.1 - 3.5e-07 30.7 0.0 7.2e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII72731.1 - 1.6e-05 25.5 0.0 4.1e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII72731.1 - 0.0027 18.0 0.1 0.0067 16.7 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII72731.1 - 0.035 13.9 0.0 0.095 12.5 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.6 KII72731.1 - 0.093 12.5 3.7 0.26 11.0 3.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger HJURP_mid PF12346.8 KII72732.1 - 0.071 13.6 0.9 0.14 12.6 0.9 1.5 1 1 0 1 1 1 0 Holliday junction recognition protein-associated repeat YscJ_FliF_C PF08345.11 KII72733.1 - 2.7 8.3 8.6 29 5.0 8.6 2.0 1 1 0 1 1 1 0 Flagellar M-ring protein C-terminal DUF4798 PF16055.5 KII72734.1 - 0.16 12.2 1.4 0.17 12.1 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4798) XRCC4 PF06632.12 KII72734.1 - 0.76 8.6 5.8 1.1 8.1 5.8 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Cofilin_ADF PF00241.20 KII72735.1 - 5.6e-28 97.2 0.3 6.4e-28 97.0 0.3 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Phage_TAC_4 PF08748.11 KII72735.1 - 0.072 13.4 0.1 0.13 12.6 0.0 1.5 2 0 0 2 2 2 0 Phage tail assembly chaperone RT_RNaseH PF17917.1 KII72736.1 - 2.2e-41 140.4 0.1 5.1e-41 139.2 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72736.1 - 9.9e-38 128.2 1.8 1.5e-37 127.6 0.3 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72736.1 - 2.5e-29 102.4 0.1 5.6e-29 101.2 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72736.1 - 1.2e-22 80.4 0.0 2.2e-22 79.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72736.1 - 6.2e-18 64.7 0.2 1.3e-17 63.6 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII72736.1 - 0.00048 19.9 0.0 0.0014 18.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII72736.1 - 0.0028 17.7 0.1 0.014 15.5 0.0 2.1 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain zf-H2C2 PF09337.10 KII72736.1 - 0.0054 16.9 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Serpin PF00079.20 KII72737.1 - 4e-23 82.3 0.1 4.2e-23 82.2 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cornichon PF03311.14 KII72737.1 - 0.038 14.3 0.1 0.1 12.9 0.1 1.8 1 1 1 2 2 2 0 Cornichon protein DMAP1_like PF17024.5 KII72738.1 - 0.23 11.6 0.0 0.3 11.2 0.0 1.1 1 0 0 1 1 1 0 Putative DMAP1-like Serpin PF00079.20 KII72739.1 - 2.1e-22 80.0 1.4 2.6e-22 79.7 1.4 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII72740.1 - 1.4e-16 60.8 0.1 1.4e-16 60.8 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) CagZ PF09053.10 KII72740.1 - 0.034 13.8 0.1 0.041 13.5 0.1 1.1 1 0 0 1 1 1 0 CagZ HECT PF00632.25 KII72743.1 - 2.5e-11 43.6 0.3 3.4e-11 43.2 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Flp_N PF03930.14 KII72744.1 - 0.19 11.7 3.7 0.24 11.4 0.6 2.6 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus ERK-JNK_inhib PF15002.6 KII72745.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor Serpin PF00079.20 KII72746.1 - 2.6e-16 59.9 3.4 2.7e-16 59.8 3.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNAP PF14938.6 KII72747.1 - 4.5e-09 36.1 1.2 5.1e-09 36.0 1.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 KII72747.1 - 0.064 13.3 2.2 8.6 6.6 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII72747.1 - 0.15 12.0 2.5 31 4.6 0.0 3.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 KII72747.1 - 0.15 12.3 5.3 16 6.0 0.0 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII72747.1 - 1.9 8.8 4.6 18 5.7 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Sortilin-Vps10 PF15902.5 KII72748.1 - 0.0066 15.3 0.2 0.37 9.5 0.2 3.0 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Tautomerase PF01361.21 KII72749.1 - 3.4 7.7 32.7 5.2 7.1 0.1 9.0 9 0 0 9 9 9 0 Tautomerase enzyme MNNL PF07657.13 KII72750.1 - 0.0054 16.7 2.9 0.011 15.8 2.9 1.4 1 0 0 1 1 1 1 N terminus of Notch ligand WD40 PF00400.32 KII72751.1 - 1.6e-09 38.2 1.1 0.0032 18.3 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII72751.1 - 0.02 15.2 0.0 0.62 10.4 0.0 3.2 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain SH3_9 PF14604.6 KII72751.1 - 0.19 11.6 0.2 13 5.7 0.0 2.5 2 0 0 2 2 2 0 Variant SH3 domain PP2C PF00481.21 KII72752.1 - 0.079 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C PP2C PF00481.21 KII72753.1 - 7e-21 75.0 0.0 8e-21 74.8 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C mRNA_decap_C PF16741.5 KII72753.1 - 0.00014 21.1 0.0 0.43 9.9 0.0 2.4 2 0 0 2 2 2 2 mRNA-decapping enzyme C-terminus DNA_pol_B PF00136.21 KII72754.1 - 1.8e-40 139.0 0.0 2.1e-40 138.8 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase family B XhlA PF10779.9 KII72754.1 - 0.009 16.2 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 Haemolysin XhlA PQ-loop PF04193.14 KII72755.1 - 1.3e-20 72.9 2.2 1.8e-15 56.5 0.5 2.7 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 KII72755.1 - 1.1e-05 26.3 9.5 1.9e-05 25.5 9.5 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor MtN3_slv PF03083.16 KII72755.1 - 0.25 11.4 10.8 1.8 8.6 3.0 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Herpes_LMP1 PF05297.11 KII72755.1 - 0.67 9.1 2.1 0.87 8.7 2.1 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Cyclin_C PF02984.19 KII72756.1 - 0.0097 16.0 0.2 0.023 14.8 0.2 1.7 1 1 0 1 1 1 1 Cyclin, C-terminal domain PRD PF00874.20 KII72756.1 - 0.04 14.2 1.7 0.6 10.4 0.1 2.5 1 1 0 2 2 2 0 PRD domain HAD_2 PF13419.6 KII72756.1 - 0.091 12.8 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase OB_NTP_bind PF07717.16 KII72757.1 - 2e-16 60.1 0.8 8.7e-16 58.1 0.0 2.3 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 KII72757.1 - 2.2e-13 50.4 1.0 4e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) DinB PF05163.12 KII72757.1 - 0.018 15.0 0.5 0.033 14.1 0.5 1.4 1 0 0 1 1 1 0 DinB family UPF0730 PF15827.5 KII72757.1 - 0.021 14.5 0.2 0.048 13.4 0.2 1.6 1 0 0 1 1 1 0 UPF0730 unknown protein family FlaF PF07309.11 KII72757.1 - 0.046 13.7 0.2 0.083 12.9 0.2 1.4 1 0 0 1 1 1 0 Flagellar protein FlaF Helicase_C PF00271.31 KII72758.1 - 6.7e-13 49.0 0.0 1.7e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KII72758.1 - 2.1e-07 30.9 0.0 4.5e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KII72758.1 - 0.00013 22.3 0.0 0.00035 20.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 KII72758.1 - 0.00062 19.8 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_30 PF13604.6 KII72758.1 - 0.0011 18.7 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 KII72758.1 - 0.0013 18.8 0.0 2.3 8.2 0.0 2.9 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_23 PF13476.6 KII72758.1 - 0.0025 18.4 16.5 0.017 15.6 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KII72758.1 - 0.0046 17.3 0.0 0.0088 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KII72758.1 - 0.028 13.9 0.0 0.11 11.9 0.0 2.0 3 0 0 3 3 3 0 PhoH-like protein T2SSE PF00437.20 KII72758.1 - 0.03 13.4 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 KII72758.1 - 0.038 13.6 0.2 0.11 12.1 0.2 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 KII72758.1 - 0.066 13.2 0.8 0.73 9.9 0.8 2.4 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 KII72758.1 - 0.095 12.0 4.1 0.44 9.8 0.8 2.4 1 1 1 2 2 2 0 KaiC AAA_29 PF13555.6 KII72758.1 - 0.097 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KII72758.1 - 0.42 11.1 2.5 0.72 10.4 0.0 2.6 3 0 0 3 3 3 0 ABC transporter UBA_3 PF09288.10 KII72759.1 - 0.0036 17.1 0.0 0.0073 16.1 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain IF4E PF01652.18 KII72760.1 - 5.6e-38 130.2 0.4 6.8e-38 130.0 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E HMW1C_N PF18071.1 KII72766.1 - 0.012 15.4 0.9 0.22 11.3 0.1 2.0 1 1 1 2 2 2 0 HMW1C N-terminal Tmemb_18A PF09771.9 KII72768.1 - 0.017 15.5 0.1 0.042 14.2 0.1 1.6 1 0 0 1 1 1 0 Transmembrane protein 188 IL15 PF02372.15 KII72768.1 - 0.19 11.7 0.1 0.19 11.7 0.1 2.2 2 1 0 2 2 2 0 Interleukin 15 DUF1307 PF06998.11 KII72769.1 - 0.0043 17.1 1.4 0.16 12.0 1.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF1307) DUF2344 PF10105.9 KII72769.1 - 0.057 13.3 0.2 0.073 12.9 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) BofC_C PF08955.10 KII72769.1 - 0.098 12.7 0.0 22 5.2 0.0 2.5 2 0 0 2 2 2 0 BofC C-terminal domain Orf78 PF06024.12 KII72770.1 - 0.081 13.2 0.7 0.13 12.5 0.7 1.5 1 1 0 1 1 1 0 Orf78 (ac78) SNAP PF14938.6 KII72773.1 - 3.9e-12 46.2 2.4 3.9e-12 46.2 2.4 1.9 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP UPF0203 PF05254.12 KII72773.1 - 0.073 13.3 0.4 0.073 13.3 0.4 3.2 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0203) Rep_fac-A_C PF08646.10 KII72776.1 - 0.045 13.5 1.7 0.045 13.5 1.7 1.6 2 0 0 2 2 2 0 Replication factor-A C terminal domain AdoHcyase PF05221.17 KII72782.1 - 1.4e-93 313.3 0.0 1.7e-46 158.8 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KII72782.1 - 3.8e-73 244.9 1.2 5.5e-73 244.4 1.2 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KII72782.1 - 1.5e-11 44.0 0.2 2.7e-11 43.2 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KII72782.1 - 2.5e-05 23.9 0.4 4.1e-05 23.2 0.4 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 KII72782.1 - 7.2e-05 23.0 0.2 0.0002 21.6 0.2 1.8 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 KII72782.1 - 0.0002 21.8 0.7 0.00087 19.7 0.2 2.3 3 0 0 3 3 3 1 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.19 KII72782.1 - 0.00076 18.8 1.9 0.0047 16.3 2.0 2.0 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 KII72782.1 - 0.0016 18.5 0.2 0.003 17.6 0.2 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Rpn9_C PF18261.1 KII72782.1 - 0.067 12.8 0.3 0.17 11.5 0.3 1.7 1 0 0 1 1 1 0 Rpn9 C-terminal helix Adeno_PIX PF03955.14 KII72789.1 - 0.13 12.4 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) DUF1389 PF07146.11 KII72791.1 - 0.081 12.2 0.4 0.13 11.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1389) Rossmann-like PF10727.9 KII72795.1 - 0.16 11.8 0.8 0.32 10.9 0.8 1.5 1 1 0 1 1 1 0 Rossmann-like domain LIN37 PF15306.6 KII72796.1 - 0.073 13.3 2.2 0.088 13.0 2.2 1.2 1 0 0 1 1 1 0 LIN37 BrnT_toxin PF04365.13 KII72796.1 - 0.093 13.1 5.5 0.56 10.6 0.1 2.8 3 1 1 4 4 4 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system MNE1 PF13762.6 KII72797.1 - 0.0074 16.3 2.1 0.013 15.5 2.1 1.3 1 0 0 1 1 1 1 Mitochondrial splicing apparatus component BLOC1_2 PF10046.9 KII72798.1 - 0.02 15.1 4.1 2.7 8.3 0.2 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CheZ PF04344.13 KII72798.1 - 0.026 14.4 0.3 2.4 8.0 0.1 2.2 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ Baculo_PEP_C PF04513.12 KII72798.1 - 0.039 14.0 3.5 0.94 9.5 0.4 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LXG PF04740.12 KII72798.1 - 0.058 13.1 4.1 0.74 9.5 0.2 2.4 2 0 0 2 2 2 0 LXG domain of WXG superfamily DUF948 PF06103.11 KII72798.1 - 0.064 13.5 0.4 1.4 9.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) COG5 PF10392.9 KII72798.1 - 0.08 13.1 2.6 0.27 11.4 0.0 2.7 3 1 0 3 3 3 0 Golgi transport complex subunit 5 RecG_N PF17190.4 KII72798.1 - 0.084 13.6 3.4 0.92 10.3 0.3 2.5 2 0 0 2 2 2 0 RecG N-terminal helical domain DUF1722 PF08349.11 KII72798.1 - 0.58 10.5 3.1 1.1 9.5 1.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1722) YabA PF06156.13 KII72798.1 - 0.71 10.5 3.2 9.7 6.9 0.2 2.4 2 0 0 2 2 2 0 Initiation control protein YabA SNF2_N PF00176.23 KII72799.1 - 1.1e-59 201.9 0.8 2.9e-59 200.5 0.3 1.8 1 1 1 2 2 2 1 SNF2 family N-terminal domain Chromo PF00385.24 KII72799.1 - 7.4e-28 96.2 3.4 7.4e-16 57.8 0.1 3.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 KII72799.1 - 6.6e-20 71.5 0.0 1.7e-19 70.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII72799.1 - 4.2e-08 33.4 0.0 3.7e-07 30.3 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4208 PF13907.6 KII72799.1 - 0.0023 18.3 0.1 0.014 15.9 0.1 2.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) CDH1_2_SANT_HL1 PF18375.1 KII72799.1 - 0.018 15.7 0.2 0.018 15.7 0.2 3.3 3 0 0 3 3 3 0 CDH1/2 SANT-Helical linker 1 FliH PF02108.16 KII72800.1 - 0.063 13.4 0.0 0.082 13.0 0.0 1.4 1 1 0 1 1 1 0 Flagellar assembly protein FliH AI-2E_transport PF01594.16 KII72800.1 - 0.21 10.7 0.1 0.23 10.6 0.1 1.1 1 0 0 1 1 1 0 AI-2E family transporter BAG6 PF12057.8 KII72801.1 - 0.00034 20.3 0.0 0.00089 18.9 0.0 1.8 1 0 0 1 1 1 1 BCL2-associated athanogene 6 DUF5338 PF17273.2 KII72801.1 - 0.16 12.1 0.1 0.5 10.5 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5338) DUF2070 PF09843.9 KII72802.1 - 0.32 9.2 4.0 0.32 9.2 4.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DDE_Tnp_IS1595 PF12762.7 KII72804.1 - 6e-17 62.1 0.3 1.5e-16 60.8 0.1 1.8 2 1 0 2 2 2 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII72804.1 - 0.002 17.9 0.0 0.0045 16.7 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease WD40 PF00400.32 KII72806.1 - 1.6e-33 114.2 22.1 2.1e-07 31.5 0.1 9.2 9 1 1 10 10 10 6 WD domain, G-beta repeat Utp12 PF04003.12 KII72806.1 - 5.8e-18 65.2 0.1 1.2e-17 64.1 0.1 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 KII72806.1 - 6.1e-18 64.9 0.1 0.013 15.8 0.0 8.0 4 3 5 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KII72806.1 - 4.4e-05 22.9 4.4 0.00059 19.3 0.3 3.9 4 1 1 5 5 5 1 WD40-like domain Ge1_WD40 PF16529.5 KII72806.1 - 0.001 18.1 0.8 0.61 9.0 0.0 4.7 4 2 2 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KII72806.1 - 0.0069 16.3 0.0 8.9 6.4 0.0 4.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 KII72806.1 - 0.025 14.6 0.0 15 5.7 0.0 3.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DUF2850 PF11012.8 KII72806.1 - 0.037 14.3 0.0 11 6.4 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2850) PAN_3 PF08277.12 KII72806.1 - 0.43 10.4 6.5 0.71 9.7 0.4 3.5 3 0 0 3 3 3 0 PAN-like domain WD40 PF00400.32 KII72808.1 - 5.2e-11 42.9 11.6 0.002 18.9 0.1 5.2 4 1 1 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII72808.1 - 9.3e-06 25.9 4.0 0.48 10.8 0.1 3.6 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain HTH_1 PF00126.27 KII72809.1 - 1.5e-17 63.3 0.2 2.5e-17 62.6 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 KII72809.1 - 4.3e-06 26.2 0.1 8.3e-06 25.3 0.0 1.6 2 0 0 2 2 2 1 LysR substrate binding domain MarR_2 PF12802.7 KII72809.1 - 0.011 15.6 0.1 0.031 14.2 0.1 1.8 1 0 0 1 1 1 0 MarR family HTH_IclR PF09339.10 KII72809.1 - 0.029 14.2 0.1 0.081 12.7 0.1 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain HU-CCDC81_euk_2 PF18289.1 KII72809.1 - 0.15 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 Aldo_ket_red PF00248.21 KII72810.1 - 6.2e-70 235.7 0.0 7.4e-70 235.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family ESCRT-II PF05871.12 KII72810.1 - 0.056 13.7 0.0 0.16 12.2 0.0 1.7 2 0 0 2 2 2 0 ESCRT-II complex subunit Flavodoxin_2 PF02525.17 KII72811.1 - 4.4e-24 85.3 0.0 4.8e-24 85.2 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold Flavin_Reduct PF01613.18 KII72812.1 - 0.00022 21.3 0.0 0.00034 20.7 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain HxlR PF01638.17 KII72813.1 - 2.4e-26 91.4 0.1 3.1e-26 91.1 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_20 PF12840.7 KII72813.1 - 0.0073 16.4 0.1 0.011 15.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain PadR PF03551.14 KII72813.1 - 0.045 13.7 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_45 PF14947.6 KII72813.1 - 0.061 13.3 0.0 0.078 13.0 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DUF505 PF04458.12 KII72813.1 - 0.074 11.4 0.0 0.076 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF505) MarR_2 PF12802.7 KII72813.1 - 0.14 12.1 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 MarR family HTH_34 PF13601.6 KII72813.1 - 0.16 12.2 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain SnoaL PF07366.12 KII72814.1 - 1.4e-10 41.1 0.1 1.8e-10 40.7 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 KII72814.1 - 6.8e-06 26.7 0.0 9e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain YceI PF04264.13 KII72815.1 - 7.7e-32 110.9 0.7 8.8e-32 110.7 0.7 1.0 1 0 0 1 1 1 1 YceI-like domain Nitroreductase PF00881.24 KII72816.1 - 5.8e-19 68.8 0.0 6.7e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 KII72816.1 - 0.094 12.3 0.0 0.23 11.0 0.0 1.6 2 0 0 2 2 2 0 Putative TM nitroreductase Kelch_4 PF13418.6 KII72817.1 - 1.7e-07 31.1 2.3 0.17 11.9 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KII72817.1 - 3.3e-05 24.0 2.8 1.4 9.3 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 KII72817.1 - 0.00075 19.0 6.2 2 8.0 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII72817.1 - 0.0024 18.1 1.3 7.7 6.9 0.0 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 KII72817.1 - 0.12 12.4 2.8 12 6.0 0.2 3.3 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 KII72818.1 - 3.3e-17 62.1 4.7 0.00012 22.2 0.3 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII72818.1 - 1.2e-14 53.6 2.3 9.3e-05 21.9 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII72818.1 - 5e-14 52.0 1.0 0.00011 22.1 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII72818.1 - 4.3e-12 46.0 3.2 0.011 16.0 0.0 3.8 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KII72818.1 - 8.2e-05 22.5 3.6 0.43 10.6 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KII72818.1 - 0.00012 21.9 1.5 5.4 7.1 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 KII72819.1 - 3.7e-15 55.6 12.1 3.8e-05 23.8 0.0 5.8 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII72819.1 - 1.9e-07 31.0 5.5 0.06 13.4 0.0 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII72819.1 - 6e-05 22.8 9.6 3.1 7.9 0.0 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII72819.1 - 0.0023 18.2 2.5 3.7 7.9 0.1 5.3 7 0 0 7 7 7 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII72819.1 - 0.034 13.8 11.8 1 9.0 0.2 5.7 6 1 0 6 6 6 0 Kelch motif Kelch_5 PF13854.6 KII72819.1 - 0.2 11.7 11.8 8.4 6.5 0.1 4.2 5 0 0 5 5 5 0 Kelch motif P22_Cro PF14549.6 KII72822.1 - 0.0067 16.2 0.0 0.013 15.3 0.0 1.4 2 0 0 2 2 2 1 DNA-binding transcriptional regulator Cro CHCH PF06747.13 KII72823.1 - 3.3e-05 23.9 0.9 5e-05 23.3 0.9 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 KII72823.1 - 0.002 18.1 1.2 0.0031 17.5 1.2 1.2 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NDUF_B7 PF05676.13 KII72823.1 - 0.016 14.9 0.9 0.023 14.4 0.9 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Hairy_orange PF07527.13 KII72823.1 - 0.019 15.2 0.2 0.03 14.5 0.2 1.4 1 0 0 1 1 1 0 Hairy Orange Cmc1 PF08583.10 KII72823.1 - 0.021 14.8 1.0 0.046 13.7 1.0 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF963 PF06131.11 KII72823.1 - 0.038 13.4 3.8 0.11 12.0 3.8 1.7 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) PHD_3 PF13922.6 KII72823.1 - 1.8 9.0 5.7 0.66 10.4 1.3 2.1 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx DDE_3 PF13358.6 KII72824.1 - 0.00033 20.5 1.8 0.014 15.1 1.5 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.7 KII72825.1 - 0.037 14.0 0.0 0.042 13.9 0.0 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain Sortilin-Vps10 PF15902.5 KII72826.1 - 0.017 14.0 0.1 0.04 12.7 0.0 1.7 1 1 0 1 1 1 0 Sortilin, neurotensin receptor 3, PSII_BNR PF14870.6 KII72826.1 - 0.088 12.1 0.0 0.14 11.4 0.0 1.4 2 0 0 2 2 2 0 Photosynthesis system II assembly factor YCF48 BNR PF02012.20 KII72826.1 - 0.1 12.7 0.2 6.8 7.1 0.0 2.6 2 0 0 2 2 2 0 BNR/Asp-box repeat Ldl_recept_a PF00057.18 KII72827.1 - 1.1e-07 31.9 7.9 1.1e-07 31.9 7.9 3.3 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII72828.1 - 8.2e-21 75.1 8.9 8.2e-21 75.1 8.9 2.8 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Ldl_recept_a PF00057.18 KII72828.1 - 2.4e-08 34.1 9.4 2.4e-08 34.1 9.4 3.8 3 1 1 4 4 4 1 Low-density lipoprotein receptor domain class A DDE_Tnp_IS1595 PF12762.7 KII72830.1 - 6.4e-05 23.0 0.0 7.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain HAP1_N PF04849.13 KII72832.1 - 9.4e-06 25.0 20.1 0.00021 20.6 20.3 2.1 1 1 0 1 1 1 1 HAP1 N-terminal conserved region Occludin_ELL PF07303.13 KII72832.1 - 0.01 16.5 5.3 0.01 16.5 5.3 2.9 2 1 2 4 4 3 0 Occludin homology domain DUF5347 PF17282.2 KII72832.1 - 0.049 13.9 1.9 0.049 13.9 1.9 2.6 1 1 0 2 2 2 0 Family of unknown function (DUF5347) YtxH PF12732.7 KII72832.1 - 0.061 13.9 0.1 3 8.4 0.0 2.7 1 1 1 2 2 2 0 YtxH-like protein DUF3578 PF12102.8 KII72832.1 - 0.077 12.6 6.9 0.037 13.6 4.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3578) Prominin PF05478.11 KII72832.1 - 0.086 10.8 6.8 0.1 10.6 6.8 1.1 1 0 0 1 1 1 0 Prominin HALZ PF02183.18 KII72832.1 - 0.12 12.6 9.9 2.6 8.3 2.1 3.0 2 1 0 2 2 2 0 Homeobox associated leucine zipper DUF334 PF03904.13 KII72832.1 - 0.17 11.4 12.0 0.28 10.7 12.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Alpha-E PF04168.12 KII72832.1 - 0.22 11.3 7.4 1.2 8.9 1.4 2.1 1 1 1 2 2 2 0 A predicted alpha-helical domain with a conserved ER motif. DivIC PF04977.15 KII72832.1 - 0.22 11.3 17.4 0.3 10.9 2.2 3.5 2 1 1 3 3 3 0 Septum formation initiator DUF2935 PF11155.8 KII72832.1 - 0.32 11.3 6.6 0.17 12.2 2.3 2.1 1 1 2 3 3 3 0 Domain of unknown function (DUF2935) DASH_Dam1 PF08653.10 KII72832.1 - 0.47 10.3 10.6 1.1 9.1 1.1 2.9 3 0 0 3 3 3 0 DASH complex subunit Dam1 DUF3450 PF11932.8 KII72832.1 - 0.53 9.5 18.8 3.2 7.0 9.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) H-kinase_dim PF02895.14 KII72832.1 - 0.72 10.3 9.6 2.7 8.5 3.2 2.9 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain FapA PF03961.13 KII72832.1 - 2.5 6.6 15.7 0.8 8.2 7.8 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A MitMem_reg PF13012.6 KII72832.1 - 2.8 8.4 6.1 11 6.5 5.2 2.2 2 1 1 3 3 2 0 Maintenance of mitochondrial structure and function ZapB PF06005.12 KII72832.1 - 4.5 7.8 24.2 23 5.5 8.5 3.5 1 1 2 3 3 3 0 Cell division protein ZapB Spectrin PF00435.21 KII72832.1 - 9.3 6.8 18.2 0.22 12.0 6.0 3.2 2 1 2 4 4 4 0 Spectrin repeat PolyA_pol PF01743.20 KII72834.1 - 0.012 16.0 0.4 0.016 15.7 0.4 1.3 1 0 0 1 1 1 0 Poly A polymerase head domain SpoIIE PF07228.12 KII72835.1 - 1e-12 48.4 0.0 2e-12 47.5 0.0 1.5 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 KII72835.1 - 1.4e-06 28.1 0.1 0.0057 16.3 0.0 2.4 2 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 KII72835.1 - 0.01 15.5 0.0 0.027 14.1 0.0 1.7 1 1 0 1 1 1 0 Protein phosphatase 2C SpuA_C PF18033.1 KII72835.1 - 0.086 12.9 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 SpuA C-terminal Pkinase PF00069.25 KII72836.1 - 3.5e-63 213.4 0.0 4.1e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII72836.1 - 1.5e-37 129.3 0.0 1.9e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII72836.1 - 7.2e-08 32.1 0.0 9.3e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KII72836.1 - 4.9e-05 22.3 0.0 0.00021 20.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KII72836.1 - 0.0024 17.8 0.0 0.0055 16.7 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KII72836.1 - 0.0053 16.4 0.1 0.067 12.8 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Seadorna_VP7 PF07387.11 KII72836.1 - 0.013 14.5 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Meleagrin PF08189.11 KII72836.1 - 0.089 12.5 0.1 0.29 10.9 0.1 1.8 1 0 0 1 1 1 0 Meleagrin/Cygnin family Kdo PF06293.14 KII72836.1 - 0.14 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_32 PF13565.6 KII72837.1 - 0.036 14.7 0.0 0.17 12.5 0.0 1.9 1 1 1 2 2 2 0 Homeodomain-like domain DUF5301 PF17225.3 KII72838.1 - 0.081 13.4 0.4 0.15 12.5 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) STAT_int PF02865.17 KII72838.1 - 0.18 12.3 0.0 0.27 11.7 0.0 1.3 1 0 0 1 1 1 0 STAT protein, protein interaction domain cNMP_binding PF00027.29 KII72839.1 - 8.2e-18 64.3 0.0 7e-09 35.6 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Patatin PF01734.22 KII72839.1 - 2e-14 54.3 4.1 8.9e-14 52.1 4.1 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase Bacteriocin_IIc PF10439.9 KII72839.1 - 1.7 8.9 6.4 2.8 8.1 6.4 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Pkinase PF00069.25 KII72840.1 - 1.2e-17 64.2 0.0 1.5e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 KII72840.1 - 4.1e-11 42.3 0.4 5.3e-11 41.9 0.4 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 KII72840.1 - 1e-05 25.0 0.0 1.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KII72840.1 - 0.0033 16.8 0.1 0.0045 16.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII72840.1 - 0.032 14.2 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RVP PF00077.20 KII72841.1 - 0.0093 16.3 0.0 0.038 14.3 0.0 2.0 2 1 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII72841.1 - 0.016 15.7 0.0 0.1 13.2 0.0 2.3 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease AT_hook PF02178.19 KII72841.1 - 6.4 7.0 8.0 0.58 10.2 1.4 2.5 2 0 0 2 2 2 0 AT hook motif Mito_carr PF00153.27 KII72842.1 - 9.5e-62 205.0 5.3 1.1e-22 79.8 0.5 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ADK PF00406.22 KII72847.1 - 1.1e-38 132.7 0.0 1.3e-38 132.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KII72847.1 - 4.6e-20 72.4 0.0 8e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 KII72847.1 - 1e-14 54.2 0.0 2.3e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 KII72847.1 - 3.1e-08 34.2 0.0 5.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KII72847.1 - 0.00027 21.1 0.0 0.00041 20.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 KII72847.1 - 0.00035 21.0 0.0 0.00094 19.6 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KII72847.1 - 0.042 13.6 0.0 0.093 12.5 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KII72847.1 - 0.042 14.1 0.0 0.063 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain tRNA_lig_kinase PF08303.11 KII72847.1 - 0.076 13.1 0.0 0.23 11.5 0.0 1.9 1 1 0 1 1 1 0 tRNA ligase kinase domain DUF5572 PF17733.1 KII72847.1 - 0.096 12.5 0.1 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5572) Zeta_toxin PF06414.12 KII72847.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Med22 PF06179.12 KII72848.1 - 7.4e-08 32.5 2.0 1e-07 32.1 2.0 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Transposase_22 PF02994.14 KII72848.1 - 0.063 13.5 0.5 0.14 12.4 0.1 1.8 2 0 0 2 2 2 0 L1 transposable element RBD-like domain RNase_H2-Ydr279 PF09468.10 KII72848.1 - 0.079 13.1 1.1 0.3 11.3 1.1 1.9 1 1 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain Sortilin_C PF15901.5 KII72850.1 - 4.1e-15 56.5 7.8 1e-14 55.2 7.8 1.7 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72850.1 - 5.2e-12 45.3 2.4 2.2e-11 43.3 2.4 2.0 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72850.1 - 3.6e-06 26.1 7.4 0.14 12.3 0.2 4.1 3 0 0 3 3 3 3 BNR/Asp-box repeat NUP214 PF16755.5 KII72850.1 - 0.011 15.0 0.0 0.025 13.8 0.0 1.6 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Baculo_LEF-11 PF06385.12 KII72850.1 - 0.076 13.5 2.4 0.12 12.9 0.5 2.4 3 0 0 3 3 3 0 Baculovirus LEF-11 protein Sortilin-Vps10 PF15902.5 KII72853.1 - 5.2e-09 35.4 5.7 2e-08 33.5 2.3 2.6 1 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII72853.1 - 8.8e-08 32.7 0.4 2.4e-07 31.3 0.2 1.8 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII72853.1 - 0.00036 20.1 8.3 3.1 8.2 0.0 4.7 4 0 0 4 4 4 3 BNR/Asp-box repeat Ldl_recept_a PF00057.18 KII72855.1 - 1.2e-07 31.9 13.2 1.2e-07 31.9 13.2 5.1 4 1 1 5 5 5 2 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII72857.1 - 8.2e-13 49.1 4.3 8.2e-13 49.1 4.3 2.2 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72857.1 - 1.5e-07 30.6 0.2 0.00049 19.0 0.0 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72857.1 - 0.00031 20.3 5.7 1.6 9.1 0.0 4.9 5 0 0 5 5 5 2 BNR/Asp-box repeat Sortilin_C PF15901.5 KII72859.1 - 1.5e-08 35.2 0.7 2.9e-08 34.2 0.7 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72859.1 - 7.6e-08 31.6 2.3 5.5e-06 25.4 0.4 2.2 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72859.1 - 5.9e-05 22.5 5.8 0.039 13.9 0.1 4.3 4 0 0 4 4 4 2 BNR/Asp-box repeat Pox_E10 PF04805.12 KII72863.1 - 0.067 13.1 0.2 0.11 12.4 0.2 1.3 1 0 0 1 1 1 0 E10-like protein conserved region Sortilin_C PF15901.5 KII72864.1 - 1.8e-12 48.0 0.3 4.6e-12 46.6 0.3 1.6 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72864.1 - 8.8e-09 34.7 0.8 1.6e-08 33.8 0.8 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72864.1 - 3.1e-06 26.3 1.2 0.39 10.9 0.0 4.0 3 0 0 3 3 3 2 BNR/Asp-box repeat DUF5301 PF17225.3 KII72864.1 - 0.047 14.1 0.1 0.1 13.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) Sortilin_C PF15901.5 KII72865.1 - 3.1e-11 43.9 0.9 3.8e-11 43.6 0.9 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII72865.1 - 0.0058 15.5 0.0 0.01 14.6 0.0 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII72865.1 - 0.095 12.8 0.4 0.095 12.8 0.4 2.7 3 0 0 3 3 3 0 BNR/Asp-box repeat DUF4215 PF13948.6 KII72867.1 - 0.13 12.7 0.4 0.13 12.7 0.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4215) EppA_BapA PF07268.11 KII72868.1 - 0.0086 16.0 1.1 0.017 15.1 1.1 1.4 1 0 0 1 1 1 1 Exported protein precursor (EppA/BapA) Kunitz_BPTI PF00014.23 KII72874.1 - 3e-10 40.2 14.6 1.5e-09 37.9 9.3 2.4 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Actin PF00022.19 KII72875.1 - 1.2e-149 498.4 0.0 3.8e-149 496.7 0.0 1.6 1 1 0 1 1 1 1 Actin Actin PF00022.19 KII72876.1 - 3.8e-120 401.2 0.0 1.9e-119 399.0 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KII72876.1 - 5.9e-05 22.1 0.0 0.00067 18.6 0.0 2.3 1 1 0 1 1 1 1 MreB/Mbl protein CPL PF08144.11 KII72877.1 - 0.011 16.1 1.1 3 8.2 0.0 3.2 2 1 1 3 3 3 0 CPL (NUC119) domain PRRSV_2b PF07069.11 KII72880.1 - 0.025 15.1 0.1 0.05 14.1 0.1 1.4 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b DUF4389 PF14333.6 KII72880.1 - 0.27 11.2 2.8 0.49 10.3 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) Annexin PF00191.20 KII72881.1 - 0.00016 21.7 0.1 0.021 14.9 0.0 2.3 2 0 0 2 2 2 2 Annexin Annexin PF00191.20 KII72884.1 - 1.2e-17 63.7 5.0 2.6e-08 33.8 0.0 3.4 3 0 0 3 3 3 3 Annexin VCBS PF13517.6 KII72886.1 - 8.6e-06 26.3 1.2 3.8e-05 24.2 1.3 2.2 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII72886.1 - 1.7e-05 24.8 2.5 0.00027 21.0 0.1 2.9 3 0 0 3 3 3 1 FG-GAP repeat FG-GAP PF01839.23 KII72887.1 - 0.028 14.6 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 FG-GAP repeat Annexin PF00191.20 KII72890.1 - 0.0073 16.4 3.1 6.5 6.9 0.5 3.3 1 1 2 3 3 3 2 Annexin Ribosomal_S10 PF00338.22 KII72890.1 - 0.0091 16.2 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e UDPG_MGDP_dh_N PF03721.14 KII72890.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DRIM PF07539.12 KII72893.1 - 0.00086 17.7 1.0 0.013 13.8 0.1 2.1 2 0 0 2 2 2 2 Down-regulated in metastasis V-ATPase_H_C PF11698.8 KII72893.1 - 0.0086 16.2 1.4 0.56 10.3 0.0 3.1 3 0 0 3 3 3 1 V-ATPase subunit H Usg PF06233.12 KII72893.1 - 0.024 14.8 0.3 0.24 11.6 0.0 2.3 2 0 0 2 2 2 0 Usg-like family Colicin_immun PF09204.10 KII72893.1 - 0.11 13.0 2.7 1.3 9.5 0.1 2.4 2 0 0 2 2 2 0 Bacterial self-protective colicin-like immunity Serpin PF00079.20 KII72894.1 - 3.5e-46 158.2 5.7 3.9e-46 158.0 5.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Annexin PF00191.20 KII72895.1 - 2.5e-05 24.3 3.9 0.0097 16.0 0.7 3.4 3 0 0 3 3 3 3 Annexin Annexin PF00191.20 KII72898.1 - 3.3e-12 46.3 1.1 7.9e-08 32.3 0.0 2.6 2 0 0 2 2 2 2 Annexin Annexin PF00191.20 KII72899.1 - 7.7e-19 67.5 5.4 4.8e-11 42.6 0.2 3.7 4 0 0 4 4 4 3 Annexin DDE_3 PF13358.6 KII72901.1 - 3.2e-09 36.7 0.0 3.9e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH_2 PF17919.1 KII72903.1 - 0.0012 18.8 0.0 0.0037 17.3 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72903.1 - 0.0014 18.2 0.0 0.0036 16.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII72903.1 - 0.008 16.3 1.1 0.014 15.5 0.1 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain RT_RNaseH PF17917.1 KII72903.1 - 0.044 14.1 0.0 8.5 6.7 0.0 2.6 1 1 1 2 2 2 0 RNase H-like domain found in reverse transcriptase DDE_Tnp_IS1595 PF12762.7 KII72904.1 - 3.4e-07 30.4 0.0 8.3e-07 29.1 0.0 1.6 2 0 0 2 2 2 1 ISXO2-like transposase domain zf-RING_4 PF14570.6 KII72904.1 - 0.065 13.0 2.3 0.1 12.4 1.3 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RecR PF02132.15 KII72904.1 - 0.092 12.3 4.3 0.16 11.6 4.3 1.4 1 0 0 1 1 1 0 RecR protein TraS PF10624.9 KII72905.1 - 0.0076 16.2 3.0 0.0076 16.2 3.0 1.9 1 1 1 2 2 2 1 Plasmid conjugative transfer entry exclusion protein TraS DUF2448 PF10476.9 KII72905.1 - 0.084 12.7 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) GWT1 PF06423.12 KII72905.1 - 0.1 12.7 5.9 0.85 9.7 5.9 2.4 1 1 0 1 1 1 0 GWT1 PMP22_Claudin PF00822.20 KII72905.1 - 1.2 9.0 9.0 0.15 11.9 3.3 2.2 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family DUF4064 PF13273.6 KII72905.1 - 2.1 8.7 13.9 1.8 8.9 8.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) ARL6IP6 PF15062.6 KII72906.1 - 0.083 13.0 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix Annexin PF00191.20 KII72908.1 - 5.7e-18 64.8 4.9 3e-11 43.2 0.3 3.2 3 0 0 3 3 3 2 Annexin TcdA_TcdB PF12919.7 KII72908.1 - 0.0036 16.7 0.3 0.28 10.4 0.1 2.1 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain Sialidase PF02973.16 KII72908.1 - 0.0055 16.2 1.0 0.02 14.4 0.3 2.0 2 0 0 2 2 2 1 Sialidase, N-terminal domain Prok-RING_4 PF14447.6 KII72908.1 - 0.0072 16.2 0.8 0.019 14.8 0.8 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KII72908.1 - 0.065 13.2 5.1 0.18 11.8 5.0 1.8 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 KII72908.1 - 0.07 13.2 1.2 0.16 12.0 1.2 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KII72908.1 - 0.47 10.3 4.3 2.2 8.2 4.3 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Annexin PF00191.20 KII72910.1 - 7.4e-18 64.4 9.8 6.3e-10 39.0 0.2 3.4 2 1 1 3 3 3 3 Annexin SRP1_TIP1 PF00660.17 KII72910.1 - 0.11 12.6 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 Seripauperin and TIP1 family PXA PF02194.15 KII72914.1 - 0.076 13.0 0.3 0.12 12.3 0.3 1.4 1 1 0 1 1 1 0 PXA domain Serpin PF00079.20 KII72915.1 - 3.8e-23 82.4 0.3 4.4e-23 82.2 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII72916.1 - 1.4e-17 64.1 1.2 5.6e-17 62.1 1.2 1.8 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) RR_TM4-6 PF06459.12 KII72916.1 - 0.0041 17.0 5.2 0.0049 16.7 5.2 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 RNA_pol_Rpc4 PF05132.14 KII72916.1 - 0.0066 16.9 2.7 0.0074 16.7 2.7 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 Nop14 PF04147.12 KII72916.1 - 0.0072 14.6 20.0 0.0085 14.4 20.0 1.1 1 0 0 1 1 1 1 Nop14-like family DUF913 PF06025.12 KII72916.1 - 0.0077 15.3 3.4 0.0081 15.2 3.4 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 KII72916.1 - 0.093 12.9 6.0 0.12 12.5 6.0 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Tim54 PF11711.8 KII72916.1 - 0.14 11.0 9.2 0.17 10.6 9.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SAPS PF04499.15 KII72916.1 - 0.14 10.9 7.6 0.15 10.8 7.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 KII72916.1 - 0.16 10.7 7.4 0.18 10.5 7.4 1.1 1 0 0 1 1 1 0 Presenilin Merozoite_SPAM PF07133.11 KII72916.1 - 0.2 11.7 29.8 0.27 11.2 29.8 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC45 PF02724.14 KII72916.1 - 0.2 9.9 17.6 0.24 9.7 17.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop25 PF09805.9 KII72916.1 - 0.22 12.0 15.4 0.28 11.7 15.4 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Smg8_Smg9 PF10220.9 KII72916.1 - 0.22 9.8 8.8 0.25 9.6 8.8 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Band_3_cyto PF07565.13 KII72916.1 - 0.24 11.1 3.7 0.31 10.8 3.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SDA1 PF05285.12 KII72916.1 - 0.27 10.6 26.0 0.35 10.3 26.0 1.1 1 0 0 1 1 1 0 SDA1 CobT PF06213.12 KII72916.1 - 0.41 10.0 23.2 0.5 9.7 23.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NPR3 PF03666.13 KII72916.1 - 0.43 9.3 8.1 0.5 9.1 8.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pes-10 PF07149.11 KII72916.1 - 0.43 9.6 15.3 0.5 9.4 15.3 1.1 1 0 0 1 1 1 0 Pes-10 SLC12 PF03522.15 KII72916.1 - 0.45 9.5 5.0 0.52 9.3 5.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TRAP_alpha PF03896.16 KII72916.1 - 0.46 9.6 10.0 0.64 9.2 10.0 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pex14_N PF04695.13 KII72916.1 - 0.47 11.1 7.6 0.64 10.7 7.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Vfa1 PF08432.10 KII72916.1 - 0.59 10.4 10.4 0.78 10.0 10.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RP-C_C PF11800.8 KII72916.1 - 0.69 10.0 5.7 1 9.4 5.7 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Hid1 PF12722.7 KII72916.1 - 1.1 7.3 8.3 1.3 7.1 8.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BIRC6 PF12356.8 KII72916.1 - 1.1 8.6 6.2 1.6 8.1 6.2 1.4 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 BUD22 PF09073.10 KII72916.1 - 1.4 8.2 21.1 1.6 8.0 21.1 1.1 1 0 0 1 1 1 0 BUD22 RRN3 PF05327.11 KII72916.1 - 2.9 6.3 17.1 3.6 6.0 17.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Zip PF02535.22 KII72916.1 - 3.4 6.8 7.0 4.2 6.5 7.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4820 PF16091.5 KII72916.1 - 4.6 6.5 10.2 6 6.2 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TFIIA PF03153.13 KII72916.1 - 7.8 6.4 21.5 8.9 6.2 21.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PTPRCAP PF15713.5 KII72916.1 - 9.3 6.5 22.3 14 6.0 22.3 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RT_RNaseH_2 PF17919.1 KII72917.1 - 8.1e-34 115.7 0.0 1.6e-33 114.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII72917.1 - 1.4e-32 112.0 0.0 3.1e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII72917.1 - 3e-20 72.7 0.0 6.6e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII72917.1 - 1.1e-19 70.8 0.0 2.6e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72917.1 - 8.9e-14 51.3 0.2 4.4e-13 49.1 0.0 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII72917.1 - 3.2e-06 26.8 0.2 2.9e-05 23.7 0.0 2.8 3 0 0 3 3 3 1 Integrase core domain zf-H2C2 PF09337.10 KII72917.1 - 0.00015 21.9 0.0 0.00055 20.1 0.1 2.0 2 0 0 2 2 2 1 H2C2 zinc finger Agenet PF05641.12 KII72917.1 - 0.02 15.4 0.3 0.076 13.5 0.1 2.2 2 0 0 2 2 2 0 Agenet domain HypA PF01155.19 KII72917.1 - 1.7 8.7 7.3 0.33 11.0 3.3 1.9 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-CCHC PF00098.23 KII72917.1 - 2.7 8.2 15.2 0.026 14.6 6.1 2.5 2 0 0 2 2 2 0 Zinc knuckle Vezatin PF12632.7 KII72923.1 - 0.014 14.8 0.2 0.016 14.6 0.2 1.1 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes Ldh_1_N PF00056.23 KII72924.1 - 2.5e-08 34.1 0.0 3.6e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Gly_kinase PF02595.15 KII72924.1 - 0.0018 17.4 0.4 0.0022 17.1 0.4 1.1 1 0 0 1 1 1 1 Glycerate kinase family Semialdhyde_dh PF01118.24 KII72924.1 - 0.13 12.7 0.1 0.19 12.1 0.1 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Arg_repressor PF01316.21 KII72925.1 - 1.7e-26 91.7 0.1 2.6e-26 91.2 0.1 1.3 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain Arg_repressor_C PF02863.18 KII72925.1 - 1.6e-21 75.9 0.1 3.2e-21 75.0 0.1 1.5 1 0 0 1 1 1 1 Arginine repressor, C-terminal domain DUF2114 PF09887.9 KII72925.1 - 0.022 13.3 0.0 0.074 11.5 0.0 1.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2114) DUF1471 PF07338.13 KII72926.1 - 8.1e-26 89.8 1.1 1.4e-18 66.6 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1471) Shisa PF13908.6 KII72929.1 - 0.0058 16.9 0.7 0.0075 16.5 0.7 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF2244 PF10003.9 KII72929.1 - 0.009 15.7 0.3 0.01 15.5 0.3 1.1 1 0 0 1 1 1 1 Integral membrane protein (DUF2244) Pex24p PF06398.11 KII72929.1 - 0.026 13.5 1.1 0.028 13.4 1.1 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin EVC2_like PF12297.8 KII72929.1 - 0.062 12.0 0.2 0.079 11.6 0.2 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DUF5305 PF17231.2 KII72929.1 - 0.092 12.1 0.8 0.12 11.7 0.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) BNR_2 PF13088.6 KII72929.1 - 0.12 11.7 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 BNR repeat-like domain CD34_antigen PF06365.12 KII72929.1 - 0.13 11.8 0.2 0.16 11.6 0.2 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4870 PF09685.10 KII72929.1 - 0.21 11.7 8.9 0.31 11.2 8.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) HemY_N PF07219.13 KII72929.1 - 1.2 9.4 6.7 1.6 8.9 6.7 1.2 1 0 0 1 1 1 0 HemY protein N-terminus DUF4191 PF13829.6 KII72929.1 - 1.4 8.2 8.3 1.8 7.8 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) WBP-1 PF11669.8 KII72929.1 - 3.3 8.4 7.2 54 4.5 7.2 2.1 1 1 0 1 1 1 0 WW domain-binding protein 1 DUF2207 PF09972.9 KII72929.1 - 3.5 6.3 9.4 4.2 6.0 9.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MMPL PF03176.15 KII72929.1 - 3.8 6.4 9.3 5.3 5.9 9.3 1.2 1 0 0 1 1 1 0 MMPL family PRIMA1 PF16101.5 KII72929.1 - 4.1 7.5 5.1 6.3 6.9 5.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Luciferase_N PF05295.11 KII72932.1 - 0.057 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain Presenilin PF01080.17 KII72932.1 - 0.2 10.4 5.8 0.29 9.8 5.8 1.2 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 KII72932.1 - 0.58 7.2 5.5 0.72 6.9 5.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 KII72932.1 - 9.9 4.1 10.1 12 3.9 10.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RelE PF06296.12 KII72933.1 - 0.18 12.0 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 RelE toxin of RelE / RelB toxin-antitoxin system PH_8 PF15409.6 KII72935.1 - 0.12 12.6 0.0 0.32 11.3 0.0 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain DUF5580 PF17743.1 KII72936.1 - 0.036 12.6 0.0 0.039 12.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) RT_RNaseH PF17917.1 KII72937.1 - 2.8e-27 95.1 0.0 5.7e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII72937.1 - 1.4e-25 89.2 0.0 2.9e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII72937.1 - 8e-09 35.7 0.1 3.9e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII72937.1 - 0.00037 20.5 0.0 0.0008 19.5 0.0 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII72937.1 - 0.00043 19.9 0.4 0.094 12.2 0.0 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Serpin PF00079.20 KII72938.1 - 3e-23 82.7 1.5 3.2e-23 82.6 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Cystatin PF00031.21 KII72939.1 - 0.061 13.6 0.0 0.093 13.0 0.0 1.3 1 0 0 1 1 1 0 Cystatin domain DDE_3 PF13358.6 KII72943.1 - 4.9e-05 23.1 0.9 8.6e-05 22.3 0.9 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Kelch_6 PF13964.6 KII72944.1 - 5.1e-12 45.6 4.0 0.073 13.4 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KII72944.1 - 1.4e-07 31.4 5.0 0.097 12.7 0.0 4.8 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII72944.1 - 2.4e-07 30.4 3.7 0.057 13.4 0.1 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 KII72944.1 - 1.5e-05 25.2 6.7 0.07 13.4 0.0 5.6 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII72944.1 - 3.3e-05 23.4 8.2 0.3 10.7 0.1 5.2 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 KII72944.1 - 0.15 12.0 3.1 18 5.5 0.0 3.9 5 0 0 5 5 5 0 Kelch motif T4_tail_cap PF11091.8 KII72945.1 - 0.055 12.4 0.0 0.072 12.0 0.0 1.1 1 0 0 1 1 1 0 Tail-tube assembly protein AAA_24 PF13479.6 KII72946.1 - 0.0057 16.4 0.0 0.0082 15.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain Pox_A32 PF04665.12 KII72946.1 - 0.0076 15.7 0.2 0.013 15.0 0.2 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein AAA_7 PF12775.7 KII72946.1 - 0.0084 15.6 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 KII72946.1 - 0.01 15.0 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 KII72946.1 - 0.011 16.2 0.0 0.02 15.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 KII72946.1 - 0.022 15.1 0.0 0.031 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 KII72946.1 - 0.026 15.0 0.0 0.045 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KII72946.1 - 0.03 14.6 0.0 0.045 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KII72946.1 - 0.037 13.8 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.15 KII72946.1 - 0.1 12.6 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PhoH PF02562.16 KII72946.1 - 0.22 10.9 0.0 0.34 10.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein COMPASS-Shg1 PF05205.12 KII72947.1 - 0.00058 20.5 0.1 0.00077 20.1 0.1 1.2 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 HJURP_C PF12347.8 KII72947.1 - 0.14 12.3 0.4 0.14 12.3 0.4 1.7 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat DUF1104 PF06518.11 KII72947.1 - 0.31 11.4 3.4 2 8.9 3.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1104) Elf1 PF05129.13 KII72948.1 - 0.081 13.0 0.4 0.096 12.7 0.4 1.2 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Ferrochelatase PF00762.19 KII72950.1 - 0.0085 15.2 0.2 0.032 13.3 0.1 1.8 1 1 1 2 2 2 1 Ferrochelatase Fe_hyd_SSU PF02256.17 KII72950.1 - 0.22 11.6 1.4 0.57 10.3 1.4 1.8 1 0 0 1 1 1 0 Iron hydrogenase small subunit Fibrinogen_BP PF08017.11 KII72952.1 - 0.095 11.1 43.0 5.1 5.4 21.5 2.7 1 1 1 2 2 2 0 Fibrinogen binding protein Cornifin PF02389.15 KII72952.1 - 0.87 9.8 5.4 4.4 7.5 0.7 3.3 2 1 0 2 2 2 0 Cornifin (SPRR) family Cornifin PF02389.15 KII72953.1 - 0.043 14.0 0.8 3.8 7.7 0.1 2.7 2 1 0 2 2 2 0 Cornifin (SPRR) family Fibrinogen_BP PF08017.11 KII72953.1 - 0.1 11.0 38.3 0.072 11.5 8.7 2.1 1 1 0 2 2 2 0 Fibrinogen binding protein SNAP PF14938.6 KII72954.1 - 3.3e-12 46.4 3.0 4.1e-12 46.1 3.0 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DHR-2 PF06920.13 KII72954.1 - 0.0027 16.4 0.3 0.0029 16.3 0.3 1.0 1 0 0 1 1 1 1 Dock homology region 2 TPR_2 PF07719.17 KII72954.1 - 0.039 14.1 6.2 0.96 9.7 0.6 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat NSF PF02071.20 KII72954.1 - 0.18 12.6 7.6 13 7.1 0.5 4.2 3 2 2 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_6 PF13174.6 KII72954.1 - 0.21 12.3 2.5 2.3 9.0 0.1 2.6 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII72954.1 - 0.52 10.2 7.1 12 5.9 0.3 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.6 KII72955.1 - 9.8e-10 39.2 0.0 2e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_hydro_49 PF03718.13 KII72955.1 - 0.038 14.0 0.1 0.43 10.6 0.1 2.0 1 1 1 2 2 2 0 Glycosyl hydrolase family 49 P4Ha_N PF08336.11 KII72956.1 - 6.8e-15 55.3 0.0 1.2e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF5601 PF18151.1 KII72956.1 - 0.052 13.9 0.3 1.7 9.0 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5601) Tnp_P_element PF12017.8 KII72957.1 - 0.058 12.8 0.0 0.17 11.3 0.0 1.7 1 1 1 2 2 2 0 Transposase protein Kunitz_BPTI PF00014.23 KII72962.1 - 0.027 14.7 17.4 0.21 11.8 7.2 2.4 2 0 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain Kunitz_BPTI PF00014.23 KII72963.1 - 8.2e-05 22.8 20.4 0.00056 20.1 8.9 2.7 3 0 0 3 3 3 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Tna_leader PF08053.11 KII72966.1 - 2.9 8.0 8.8 19 5.4 0.4 3.9 1 1 3 4 4 4 0 Tryptophanase operon leader peptide Homeodomain PF00046.29 KII72968.1 - 2.3e-17 62.5 0.7 3.7e-17 61.9 0.7 1.3 1 0 0 1 1 1 1 Homeodomain HTH_26 PF13443.6 KII72968.1 - 0.13 12.7 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain CENP-B_N PF04218.13 KII72968.1 - 0.14 11.8 0.5 0.32 10.6 0.0 1.8 2 1 0 2 2 2 0 CENP-B N-terminal DNA-binding domain Ribosomal_S3_C PF00189.20 KII72969.1 - 2.7e-21 75.9 0.8 1.2e-20 73.8 1.8 1.6 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 KII72969.1 - 2.2e-05 24.2 0.0 4.4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 KH domain Glyco_transf_10 PF00852.19 KII72971.1 - 1.9e-35 122.2 0.6 2.8e-35 121.6 0.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 KII72971.1 - 0.0012 19.3 0.5 0.0035 17.8 0.1 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal ARPC4 PF05856.12 KII72971.1 - 0.012 15.3 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) Spc110_C PF18520.1 KII72973.1 - 0.026 14.1 0.0 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 Spindle pole body component 110 C-terminal domain Glycos_transf_2 PF00535.26 KII72974.1 - 0.017 14.9 0.1 0.027 14.3 0.1 1.5 1 1 0 1 1 1 0 Glycosyl transferase family 2 Hexokinase_2 PF03727.16 KII72975.1 - 7.2e-68 228.6 0.0 1e-67 228.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KII72975.1 - 2.3e-53 181.1 0.0 3.2e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF3615 PF12274.8 KII72976.1 - 0.013 16.0 0.2 0.016 15.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3615) rpo30_N PF12410.8 KII72976.1 - 0.014 15.3 0.6 0.02 14.8 0.6 1.2 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit DDE_3 PF13358.6 KII72977.1 - 8.9e-17 61.2 0.2 1.2e-16 60.7 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Adap_comp_sub PF00928.21 KII72977.1 - 0.1 11.9 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Adaptor complexes medium subunit family Cyt-b5 PF00173.28 KII72978.1 - 1.1e-20 73.6 0.2 1.3e-20 73.3 0.2 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain UPF0203 PF05254.12 KII72979.1 - 7.5e-20 71.0 0.9 1.1e-19 70.5 0.9 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 KII72979.1 - 0.0018 18.4 3.3 0.035 14.3 0.5 2.4 1 1 1 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein CHCH PF06747.13 KII72979.1 - 0.0074 16.4 1.4 0.013 15.6 0.3 2.0 2 0 0 2 2 2 1 CHCH domain Cmc1 PF08583.10 KII72979.1 - 0.01 15.8 2.2 0.56 10.3 0.1 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 KII72979.1 - 0.033 14.6 2.4 0.067 13.5 1.6 1.9 1 1 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Evr1_Alr PF04777.13 KII72981.1 - 0.025 15.0 0.0 0.05 14.1 0.0 1.5 1 1 0 1 1 1 0 Erv1 / Alr family Myb_DNA-binding PF00249.31 KII72982.1 - 6.9e-10 39.0 1.1 0.00046 20.3 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII72982.1 - 9.9e-09 35.3 0.9 0.0047 17.2 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Xin PF08043.12 KII72983.1 - 1 9.1 0.1 1 9.1 0.1 2.6 3 0 0 3 3 3 0 Xin repeat RVT_1 PF00078.27 KII72985.1 - 1.3e-20 73.9 0.2 1.6e-20 73.6 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII72986.1 - 2.6e-07 30.7 0.3 4.5e-07 29.9 0.3 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII72987.1 - 1.7e-14 54.0 0.0 2.3e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII72987.1 - 0.00015 21.5 0.0 0.00022 20.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII72987.1 - 0.01 15.6 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Mrr_cat PF04471.12 KII72990.1 - 0.067 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease TBCC_N PF16752.5 KII72990.1 - 0.69 10.4 3.1 1.9 9.0 1.6 2.4 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF572 PF04502.13 KII72992.1 - 0.076 12.6 0.2 0.085 12.5 0.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SNAP PF14938.6 KII72994.1 - 1.9e-12 47.2 1.1 2.8e-12 46.7 1.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KII72994.1 - 0.0017 18.6 2.9 0.0055 17.0 0.9 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KII72994.1 - 0.026 14.6 0.3 0.026 14.6 0.3 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KII72994.1 - 0.059 13.4 1.4 0.34 11.1 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 KII72994.1 - 0.099 12.7 1.8 0.68 10.0 0.2 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain VPR PF00522.18 KII72995.1 - 0.097 12.7 0.2 0.16 12.0 0.2 1.4 1 0 0 1 1 1 0 VPR/VPX protein PFL-like PF02901.15 KII72996.1 - 0.061 11.9 0.1 0.061 11.9 0.1 1.0 1 0 0 1 1 1 0 Pyruvate formate lyase-like ADH_zinc_N PF00107.26 KII73001.1 - 0.0033 17.4 0.0 0.0045 17.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KII73002.1 - 1.2e-05 25.2 0.0 1.5e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain VMR2 PF17055.5 KII73003.1 - 0.099 12.4 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 Viral matrix protein M2 MULE PF10551.9 KII73004.1 - 3.6e-15 56.1 0.1 4.3e-13 49.5 0.1 2.4 2 0 0 2 2 2 2 MULE transposase domain FLYWCH PF04500.16 KII73004.1 - 5.5e-14 52.0 3.9 5.5e-14 52.0 3.9 1.8 2 0 0 2 2 2 1 FLYWCH zinc finger domain Zn_ribbon_recom PF13408.6 KII73004.1 - 0.93 10.1 6.0 2 9.0 6.0 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Inhibitor_I29 PF08246.12 KII73010.1 - 0.068 13.6 0.0 0.092 13.2 0.0 1.3 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) DUF2244 PF10003.9 KII73010.1 - 0.079 12.6 0.0 0.84 9.3 0.0 1.9 1 1 1 2 2 2 0 Integral membrane protein (DUF2244) Spin-Ssty PF02513.17 KII73013.1 - 0.057 13.2 0.0 0.17 11.6 0.0 1.8 1 0 0 1 1 1 0 Spin/Ssty Family Mucin PF01456.17 KII73016.1 - 0.031 14.3 10.0 0.043 13.8 10.0 1.3 1 1 0 1 1 1 0 Mucin-like glycoprotein DUF4176 PF13780.6 KII73018.1 - 0.083 12.9 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) Sortilin_C PF15901.5 KII73021.1 - 2.2e-13 50.9 1.0 3.6e-13 50.2 0.1 1.7 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII73021.1 - 0.00022 20.8 1.0 0.14 12.3 0.2 3.2 3 0 0 3 3 3 2 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KII73021.1 - 0.001 18.0 1.8 0.5 9.1 0.1 2.2 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, SNAP PF14938.6 KII73022.1 - 2e-07 30.7 3.5 2.6e-07 30.4 3.3 1.5 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 KII73022.1 - 0.0026 17.5 6.2 0.082 12.8 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KII73022.1 - 0.013 15.2 0.4 7.8 6.3 0.1 3.0 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.17 KII73022.1 - 0.13 12.5 3.1 6.5 7.1 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF778 PF05608.12 KII73024.1 - 0.14 12.5 0.1 0.19 12.1 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF778) RecO_C PF02565.15 KII73027.1 - 0.048 13.5 0.0 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 Recombination protein O C terminal DUF4836 PF16120.5 KII73031.1 - 0.075 12.0 0.2 0.87 8.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4836) FAM221 PF14753.6 KII73032.1 - 0.001 18.7 1.1 0.0013 18.3 1.1 1.1 1 0 0 1 1 1 1 Protein FAM221A/B DDE_3 PF13358.6 KII73034.1 - 1.9e-16 60.2 0.0 2.1e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Arm PF00514.23 KII73035.1 - 1.6e-21 75.6 3.6 0.00038 20.4 0.1 7.1 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat IBB PF01749.20 KII73035.1 - 1.1e-11 45.0 0.4 2.7e-11 43.8 0.4 1.7 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.6 KII73035.1 - 8.3e-11 42.2 0.0 0.34 11.5 0.0 6.0 5 1 2 7 7 7 4 HEAT-like repeat Arm_3 PF16186.5 KII73035.1 - 9.2e-11 41.1 3.6 2e-10 40.1 3.6 1.6 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 KII73035.1 - 1.2e-08 35.2 0.0 0.0069 16.8 0.0 5.1 4 2 3 7 7 7 2 HEAT repeats HEAT PF02985.22 KII73035.1 - 8.4e-06 25.6 1.1 1.2 9.6 0.0 5.3 6 0 0 6 6 6 1 HEAT repeat Arm_2 PF04826.13 KII73035.1 - 4.1e-05 23.2 6.4 0.0017 17.9 0.1 3.1 3 0 0 3 3 3 2 Armadillo-like Sec7_N PF12783.7 KII73035.1 - 0.033 14.1 1.4 0.17 11.8 1.1 2.4 1 1 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF5411 PF17424.2 KII73035.1 - 0.13 12.2 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5411) NopRA1 PF16201.5 KII73035.1 - 0.15 11.7 3.0 7.1 6.2 0.0 4.1 3 2 1 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 NuiA PF07924.11 KII73036.1 - 0.038 14.4 1.4 1.2 9.6 0.0 2.7 3 0 0 3 3 3 0 Nuclease A inhibitor-like protein UCH_N PF16674.5 KII73036.1 - 0.042 13.8 1.0 0.75 9.8 0.0 2.3 2 0 0 2 2 2 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 UL41A PF17591.2 KII73036.1 - 0.085 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL41A Ldl_recept_a PF00057.18 KII73038.1 - 2e-28 98.3 90.2 1.4e-09 37.9 17.4 5.2 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A SLC35F PF06027.12 KII73041.1 - 6.6e-14 52.1 9.5 1.1e-13 51.3 9.2 1.5 1 1 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 KII73041.1 - 1.1e-05 25.6 10.7 1.3e-05 25.4 10.7 1.1 1 0 0 1 1 1 1 EamA-like transporter family DUF4389 PF14333.6 KII73041.1 - 0.095 12.6 1.9 0.17 11.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) TctB PF07331.11 KII73041.1 - 0.23 11.7 6.8 0.31 11.3 6.8 1.3 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family SLC35F PF06027.12 KII73042.1 - 6.9e-09 35.6 3.8 8.8e-09 35.3 3.8 1.1 1 0 0 1 1 1 1 Solute carrier family 35 Herpes_UL31 PF02718.14 KII73042.1 - 0.042 12.8 1.0 0.051 12.5 0.9 1.3 1 1 0 1 1 1 0 Herpesvirus UL31-like protein FliG_C PF01706.16 KII73043.1 - 0.015 15.5 0.0 0.022 14.9 0.0 1.2 1 0 0 1 1 1 0 FliG C-terminal domain SLBB PF10531.9 KII73044.1 - 0.00023 20.9 0.0 0.00042 20.1 0.0 1.4 1 0 0 1 1 1 1 SLBB domain NADH_4Fe-4S PF10589.9 KII73044.1 - 0.0029 17.7 0.0 0.005 16.9 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Complex1_51K PF01512.17 KII73045.1 - 1.2e-37 129.2 0.0 1.6e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit zf-CCHC PF00098.23 KII73046.1 - 8.4e-06 25.6 3.3 1.6e-05 24.7 3.3 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 KII73046.1 - 0.0026 17.6 1.0 0.0059 16.4 1.0 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 KII73046.1 - 0.023 14.4 0.7 0.023 14.4 0.7 1.7 2 0 0 2 2 2 0 Zinc knuckle Forkhead PF00250.18 KII73047.1 - 3.5e-20 72.0 0.5 7.2e-20 71.0 0.5 1.5 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 KII73047.1 - 1.7e-05 25.1 0.1 0.00036 20.9 0.0 2.4 2 0 0 2 2 2 1 linker histone H1 and H5 family FLYWCH PF04500.16 KII73048.1 - 0.00096 19.2 2.7 0.0015 18.6 2.7 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain Hormone_4 PF00220.17 KII73048.1 - 0.59 10.2 5.3 0.94 9.6 0.5 2.6 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain Pentapeptide_4 PF13599.6 KII73049.1 - 0.00011 22.2 8.1 0.00061 19.9 3.0 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 KII73049.1 - 0.00081 19.5 2.1 0.071 13.3 2.0 2.9 2 1 0 2 2 2 1 Pentapeptide repeats (9 copies) HC2 PF07382.11 KII73049.1 - 0.0039 17.3 1.3 0.0049 17.0 1.3 1.2 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Pentapeptide PF00805.22 KII73049.1 - 0.0054 16.4 0.0 2.6 7.8 0.0 2.5 2 0 0 2 2 2 2 Pentapeptide repeats (8 copies) zf-Di19 PF05605.12 KII73049.1 - 0.51 10.7 3.3 6.9 7.0 0.0 2.9 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF2960 PF11173.8 KII73049.1 - 0.96 9.9 6.0 11 6.6 2.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2960) Dcc1 PF09724.9 KII73051.1 - 5.1e-43 147.6 0.3 6.2e-43 147.4 0.3 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 YTH PF04146.15 KII73054.1 - 5.6e-29 101.2 0.1 8.4e-28 97.4 0.1 2.4 1 1 0 1 1 1 1 YT521-B-like domain Serpin PF00079.20 KII73055.1 - 1e-43 150.1 0.5 1.1e-43 150.0 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RT_RNaseH_2 PF17919.1 KII73059.1 - 3.6e-36 123.2 0.1 8.8e-36 122.0 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII73059.1 - 1.7e-34 119.3 0.4 4.2e-34 118.0 0.4 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII73059.1 - 3.5e-34 117.3 0.2 9.7e-34 115.8 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII73059.1 - 3.5e-21 75.6 0.0 1.2e-20 73.9 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII73059.1 - 3e-20 72.1 0.6 8.3e-20 70.7 0.6 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII73059.1 - 2.1e-07 31.4 0.0 5.1e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII73059.1 - 1.1e-06 29.1 0.0 9.8e-06 26.1 0.1 2.3 2 0 0 2 2 2 1 Aspartyl protease zf-H2C2 PF09337.10 KII73059.1 - 0.00044 20.4 0.0 0.003 17.7 0.0 2.5 2 0 0 2 2 2 1 H2C2 zinc finger zf-CCHC PF00098.23 KII73059.1 - 0.00047 20.1 3.4 0.0015 18.5 3.4 1.9 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 KII73059.1 - 0.0045 17.2 1.1 0.011 16.0 0.1 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein Spuma_A9PTase PF03539.14 KII73059.1 - 0.06 13.5 0.0 1.8 8.7 0.0 2.6 2 0 0 2 2 2 0 Spumavirus aspartic protease (A9) Myb_DNA-bind_5 PF13873.6 KII73059.1 - 0.27 11.3 6.4 0.38 10.9 0.4 3.4 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.25 KII73060.1 - 1.5e-62 211.4 0.2 1.9e-62 211.0 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII73060.1 - 1.1e-35 123.1 0.1 1.4e-35 122.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII73060.1 - 1e-06 28.3 0.0 1.5e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KII73060.1 - 0.008 15.2 0.1 0.01 14.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KII73060.1 - 0.016 14.3 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 KII73060.1 - 0.032 13.8 0.3 0.08 12.5 0.1 1.7 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.14 KII73060.1 - 0.034 13.5 0.1 0.05 13.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII73060.1 - 0.084 12.8 0.0 0.17 11.8 0.0 1.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family TPR_1 PF00515.28 KII73062.1 - 9.1e-11 41.1 4.3 2.5e-05 23.9 0.2 4.0 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KII73062.1 - 6.1e-10 38.4 5.6 2.9e-05 23.9 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 KII73062.1 - 1.2e-09 37.9 0.2 0.0007 19.8 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KII73062.1 - 3.6e-09 36.2 0.8 0.0019 17.8 0.3 2.9 2 1 1 3 3 3 2 TPR repeat TPR_9 PF13371.6 KII73062.1 - 7.9e-06 25.9 0.2 0.0086 16.2 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KII73062.1 - 1.5e-05 24.8 5.6 0.0042 17.2 0.2 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KII73062.1 - 2.5e-05 24.8 0.4 0.027 15.1 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat CotJB PF12652.7 KII73062.1 - 0.00011 22.4 0.2 0.0003 20.9 0.1 1.8 2 0 0 2 2 2 1 CotJB protein TPR_19 PF14559.6 KII73062.1 - 0.00031 21.2 0.2 0.0065 17.0 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 KII73062.1 - 0.0007 20.1 1.3 0.15 12.8 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KII73062.1 - 0.0011 19.6 0.1 5.2 8.1 0.1 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat HEPN_AbiA_CTD PF18732.1 KII73062.1 - 0.0048 16.8 0.2 0.0089 16.0 0.1 1.5 1 1 0 1 1 1 1 HEPN like, Abia C-terminal domain TPR_12 PF13424.6 KII73062.1 - 0.23 11.8 2.7 1.1 9.6 0.3 2.7 1 1 3 4 4 4 0 Tetratricopeptide repeat Cypo_polyhedrin PF05865.11 KII73063.1 - 0.026 13.9 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 Cypovirus polyhedrin protein KH_1 PF00013.29 KII73064.1 - 8.3e-05 22.3 3.5 1.4 8.8 0.0 5.0 4 1 1 5 5 5 4 KH domain MBF1 PF08523.10 KII73065.1 - 0.0026 18.2 0.2 0.004 17.6 0.2 1.2 1 0 0 1 1 1 1 Multiprotein bridging factor 1 MFA1_2 PF17317.2 KII73068.1 - 0.039 13.7 0.5 10 6.0 0.0 2.5 2 0 0 2 2 2 0 Mating hormone A-factor 1&2 VirDNA-topo-I_N PF09266.10 KII73068.1 - 0.072 13.3 5.3 16 5.7 0.2 3.4 1 1 2 3 3 3 0 Viral DNA topoisomerase I, N-terminal YhdX PF17444.2 KII73070.1 - 0.52 10.2 0.0 0.52 10.2 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized YhdX-like Dynamin_N PF00350.23 KII73071.1 - 2.7e-19 69.9 2.2 5.7e-13 49.3 0.1 2.4 2 1 1 3 3 3 2 Dynamin family MMR_HSR1 PF01926.23 KII73071.1 - 7.4e-08 32.5 0.1 1.7e-07 31.3 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 KII73071.1 - 0.0015 17.9 0.1 0.0022 17.4 0.1 1.3 1 0 0 1 1 1 1 AIG1 family Dynamin_M PF01031.20 KII73071.1 - 0.0028 16.9 0.1 0.0045 16.2 0.1 1.3 1 0 0 1 1 1 1 Dynamin central region PduV-EutP PF10662.9 KII73071.1 - 0.005 16.6 0.2 0.075 12.8 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 KII73071.1 - 0.0068 15.7 0.1 0.026 13.8 0.0 1.8 1 1 1 2 2 2 1 Septin Roc PF08477.13 KII73071.1 - 0.012 15.8 0.3 0.41 10.9 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KII73071.1 - 0.02 14.8 0.9 0.37 10.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 KII73071.1 - 0.082 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KII73071.1 - 0.11 12.8 0.1 0.23 11.8 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain Ras PF00071.22 KII73071.1 - 0.25 10.9 1.3 2 8.0 0.0 2.3 2 1 0 2 2 2 0 Ras family Dpy-30 PF05186.13 KII73072.1 - 7.7e-09 35.1 0.1 1.4e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 Dpy-30 motif DnaB_2 PF07261.11 KII73072.1 - 0.029 14.1 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Replication initiation and membrane attachment SMK-1 PF04802.15 KII73073.1 - 7.4e-43 146.6 2.4 7.4e-43 146.6 2.4 2.4 2 1 0 2 2 2 1 Component of IIS longevity pathway SMK-1 UCH PF00443.29 KII73074.1 - 3.6e-36 125.0 1.4 3.6e-36 125.0 1.4 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KII73074.1 - 9e-16 58.3 1.8 1.9e-13 50.7 0.2 3.0 2 2 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 KII73074.1 - 0.075 12.5 2.0 1.5 8.2 2.0 2.5 1 1 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Ipi1_N PF12333.8 KII73074.1 - 0.079 13.6 0.0 0.22 12.1 0.0 1.7 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation Actin_micro PF17003.5 KII73074.1 - 0.11 11.6 6.0 0.27 10.4 4.1 2.4 2 1 0 2 2 2 0 Putative actin-like family DDE_3 PF13358.6 KII73075.1 - 1.2e-06 28.4 0.1 1.3e-06 28.2 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1310 PF07006.11 KII73075.1 - 0.053 13.5 1.0 0.35 10.9 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1310) fn3_4 PF16794.5 KII73076.1 - 0.16 11.9 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-III type domain EF-hand_7 PF13499.6 KII73077.1 - 5.5e-12 46.0 2.2 8.8e-12 45.3 2.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KII73077.1 - 3.3e-07 29.7 2.0 0.0083 16.0 0.4 2.7 1 1 1 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KII73077.1 - 1.2e-06 27.6 5.8 0.0013 18.1 0.2 3.0 3 1 1 4 4 4 2 EF hand EF-hand_8 PF13833.6 KII73077.1 - 1.7e-05 24.5 5.3 0.00023 20.9 1.5 2.6 1 1 1 2 2 2 2 EF-hand domain pair RST PF12174.8 KII73077.1 - 0.068 13.1 0.3 0.21 11.5 0.1 2.0 2 1 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain SPARC_Ca_bdg PF10591.9 KII73077.1 - 0.075 13.4 1.7 0.6 10.4 1.7 2.1 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 KII73077.1 - 0.11 12.1 1.7 0.23 11.0 0.1 2.3 2 1 0 2 2 2 0 EF hand Topoisom_I PF01028.20 KII73078.1 - 1.6e-41 142.1 4.0 1.6e-41 142.1 4.0 1.9 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 KII73078.1 - 2.2e-32 110.8 1.1 6.7e-32 109.2 0.1 2.3 2 1 0 2 2 2 1 C-terminal topoisomerase domain Lebercilin PF15619.6 KII73078.1 - 0.00062 19.5 13.2 0.0013 18.4 13.2 1.4 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease FapA PF03961.13 KII73078.1 - 0.0011 17.7 10.7 0.0014 17.3 8.5 1.7 1 1 1 2 2 2 1 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 KII73078.1 - 0.0036 16.9 3.1 0.004 16.8 3.1 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit Val_tRNA-synt_C PF10458.9 KII73078.1 - 0.013 15.7 3.1 3.1 8.2 0.1 2.5 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm SWIRM PF04433.17 KII73078.1 - 0.035 14.4 0.9 0.074 13.4 0.9 1.6 1 0 0 1 1 1 0 SWIRM domain BRE1 PF08647.11 KII73078.1 - 0.038 14.0 15.5 0.42 10.7 3.9 3.2 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase THOC7 PF05615.13 KII73078.1 - 0.042 14.1 6.1 0.068 13.5 6.1 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 Cas_DxTHG PF09455.10 KII73078.1 - 0.046 13.3 4.9 0.055 13.0 4.9 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family AAA_23 PF13476.6 KII73078.1 - 0.051 14.1 9.5 0.074 13.5 9.5 1.4 1 0 0 1 1 1 0 AAA domain Armet PF10208.9 KII73078.1 - 0.054 13.4 4.5 0.19 11.7 3.5 2.0 1 1 1 2 2 2 0 Degradation arginine-rich protein for mis-folding YkyA PF10368.9 KII73078.1 - 0.055 13.1 11.8 0.1 12.3 11.8 1.5 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein HsbA PF12296.8 KII73078.1 - 0.062 13.7 1.4 0.18 12.2 1.4 1.8 1 1 0 1 1 1 0 Hydrophobic surface binding protein A DUF641 PF04859.12 KII73078.1 - 0.078 13.3 10.6 0.07 13.5 4.5 2.8 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) DUF2935 PF11155.8 KII73078.1 - 0.078 13.3 7.0 0.059 13.7 4.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) SOGA PF11365.8 KII73078.1 - 0.081 14.1 10.6 0.12 13.6 2.6 2.2 2 0 0 2 2 2 0 Protein SOGA Csm1_N PF18504.1 KII73078.1 - 0.081 13.3 11.7 2.3 8.6 1.8 3.1 2 1 1 3 3 3 0 Csm1 N-terminal domain SpoIISA_toxin PF14171.6 KII73078.1 - 0.082 12.6 5.7 0.11 12.2 5.7 1.1 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system FlxA PF14282.6 KII73078.1 - 0.11 12.4 13.4 5.8 7.0 10.2 2.9 2 1 0 2 2 2 0 FlxA-like protein Med9 PF07544.13 KII73078.1 - 0.19 11.9 14.0 1.5 9.0 11.4 2.7 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 ADIP PF11559.8 KII73078.1 - 0.21 11.7 13.8 1.3 9.1 13.8 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding FUSC PF04632.12 KII73078.1 - 0.27 9.7 0.0 0.28 9.7 0.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family FlaC_arch PF05377.11 KII73078.1 - 0.4 11.1 11.2 4.6 7.7 2.5 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) OmpH PF03938.14 KII73078.1 - 0.42 10.9 10.9 2.7 8.3 10.9 2.2 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) PI3K_P85_iSH2 PF16454.5 KII73078.1 - 0.44 10.1 14.1 0.084 12.5 3.3 2.9 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Prefoldin PF02996.17 KII73078.1 - 0.52 10.2 11.9 4 7.4 0.5 3.1 3 0 0 3 3 3 0 Prefoldin subunit SlyX PF04102.12 KII73078.1 - 0.55 10.9 4.7 9 7.0 1.4 3.2 1 1 2 3 3 3 0 SlyX DHR10 PF18595.1 KII73078.1 - 0.57 10.3 11.3 0.29 11.2 8.1 1.9 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain YtxH PF12732.7 KII73078.1 - 0.58 10.7 3.4 7.5 7.2 3.4 2.3 1 1 0 1 1 1 0 YtxH-like protein DUF1664 PF07889.12 KII73078.1 - 0.58 10.2 6.4 2 8.5 3.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1910 PF08928.10 KII73078.1 - 0.73 9.8 5.7 1.8 8.6 5.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1910) AATF-Che1 PF13339.6 KII73078.1 - 0.87 10.3 10.6 0.52 11.0 3.0 2.2 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor DUF3450 PF11932.8 KII73078.1 - 0.89 8.8 6.4 6.1 6.1 5.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Tup_N PF08581.10 KII73078.1 - 0.94 9.8 7.7 3.9 7.9 5.5 2.8 1 1 0 2 2 2 0 Tup N-terminal Fib_alpha PF08702.10 KII73078.1 - 1 9.5 13.5 1.7 8.8 13.5 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Med10 PF09748.9 KII73078.1 - 1.1 9.3 6.2 1.7 8.6 1.1 2.6 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex Occludin_ELL PF07303.13 KII73078.1 - 1.5 9.6 12.0 2.1 9.1 8.5 2.3 1 1 1 2 2 2 0 Occludin homology domain MetOD2 PF18548.1 KII73078.1 - 1.8 8.7 8.4 6.7 6.9 1.4 2.6 1 1 1 2 2 2 0 Metanogen output domain 2 Z1 PF10593.9 KII73078.1 - 1.9 7.9 6.4 1.5 8.2 4.7 1.5 1 1 0 1 1 1 0 Z1 domain KELK PF15796.5 KII73078.1 - 2.8 8.5 12.4 6.7 7.2 9.1 2.3 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF2408 PF10303.9 KII73078.1 - 3.2 8.3 10.7 4.6 7.8 7.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) YabA PF06156.13 KII73078.1 - 3.3 8.4 12.7 7.6 7.2 1.2 2.9 1 1 2 3 3 3 0 Initiation control protein YabA DivIC PF04977.15 KII73078.1 - 3.7 7.4 11.5 1.2 8.9 1.1 2.9 2 1 1 3 3 3 0 Septum formation initiator Myb_DNA-bind_4 PF13837.6 KII73078.1 - 4 7.9 8.3 56 4.2 7.8 2.3 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain UPF0242 PF06785.11 KII73078.1 - 4.1 7.5 12.8 2.9 8.0 8.4 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF745 PF05335.13 KII73078.1 - 4.2 7.1 7.0 1.4 8.6 1.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF745) TMPIT PF07851.13 KII73078.1 - 4.5 6.4 12.4 4 6.6 8.8 1.9 1 1 0 1 1 1 0 TMPIT-like protein BST2 PF16716.5 KII73078.1 - 6.8 7.4 12.4 5.6 7.6 1.8 2.8 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 Topoisom_I_N PF02919.15 KII73079.1 - 2.7e-98 327.7 2.8 2.7e-98 327.7 2.8 1.5 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 KII73079.1 - 5.2e-43 147.0 0.6 5.2e-43 147.0 0.6 1.7 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Lactamase_B_2 PF12706.7 KII73080.1 - 7.5e-08 32.1 0.3 0.0047 16.5 0.0 2.4 1 1 1 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KII73080.1 - 0.0042 17.1 0.3 0.012 15.6 0.1 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily 7tm_1 PF00001.21 KII73081.1 - 1.6e-17 63.7 13.0 1.6e-17 63.7 13.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KII73081.1 - 0.052 13.2 24.7 0.05 13.2 23.3 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx NigD_C PF17415.2 KII73082.1 - 0.014 15.4 1.0 0.017 15.2 1.0 1.3 1 0 0 1 1 1 0 NigD-like C-terminal beta sandwich domain Ribosomal_S7e PF01251.18 KII73084.1 - 1.6e-40 138.9 0.9 1.9e-40 138.6 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S7e Raftlin PF15250.6 KII73084.1 - 0.031 13.0 0.2 0.041 12.6 0.2 1.1 1 0 0 1 1 1 0 Raftlin AgI_II_C2 PF17998.1 KII73085.1 - 0.0084 16.4 0.9 0.0094 16.3 0.9 1.1 1 0 0 1 1 1 1 Cell surface antigen I/II C2 terminal domain Mltc_N PF11873.8 KII73085.1 - 0.022 14.5 0.0 0.027 14.2 0.0 1.1 1 0 0 1 1 1 0 Membrane-bound lytic murein transglycosylase C, N-terminal domain Flu_NP PF00506.18 KII73086.1 - 0.062 11.9 0.0 0.072 11.7 0.0 1.0 1 0 0 1 1 1 0 Influenza virus nucleoprotein XFP PF03894.15 KII73088.1 - 0.0087 15.8 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase MLVIN_C PF18697.1 KII73089.1 - 0.001 19.1 0.0 0.0016 18.5 0.0 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain MULE PF10551.9 KII73090.1 - 1.9e-05 25.0 0.1 2.3e-05 24.7 0.1 1.1 1 0 0 1 1 1 1 MULE transposase domain PLAC8 PF04749.17 KII73093.1 - 3.2e-17 63.3 17.4 3.7e-17 63.2 17.4 1.1 1 0 0 1 1 1 1 PLAC8 family MAPKK1_Int PF08923.10 KII73094.1 - 0.054 13.3 0.0 3.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Mitogen-activated protein kinase kinase 1 interacting DDE_3 PF13358.6 KII73094.1 - 0.067 12.9 0.1 0.08 12.7 0.1 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease Myb_DNA-binding PF00249.31 KII73095.1 - 5.1e-23 81.0 6.0 8.7e-12 45.0 2.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII73095.1 - 5.4e-21 74.6 4.8 5.5e-13 48.9 2.4 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_Cef PF11831.8 KII73095.1 - 8e-05 22.3 0.5 8e-05 22.3 0.5 3.4 3 1 1 4 4 4 1 pre-mRNA splicing factor component Rap1_C PF11626.8 KII73095.1 - 0.012 15.7 0.7 0.19 11.9 0.1 2.7 2 1 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain DEAD PF00270.29 KII73096.1 - 7.7e-36 123.5 0.4 2e-35 122.2 0.3 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII73096.1 - 1.4e-26 93.0 0.1 6.9e-26 90.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII73096.1 - 1.7e-08 34.7 1.2 4.9e-08 33.2 0.0 2.3 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KII73096.1 - 0.002 18.5 0.0 0.0049 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KII73096.1 - 0.0021 18.4 0.1 0.011 16.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain RPW8 PF05659.11 KII73096.1 - 0.019 14.7 0.1 0.079 12.6 0.1 2.1 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 SecA_DEAD PF07517.14 KII73096.1 - 0.023 14.0 0.0 0.069 12.4 0.0 1.7 2 0 0 2 2 2 0 SecA DEAD-like domain Ig_3 PF13927.6 KII73097.1 - 3e-06 27.8 0.0 0.00049 20.6 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 KII73097.1 - 7.5e-05 22.7 0.0 0.016 15.3 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KII73097.1 - 0.003 17.9 0.1 0.25 11.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_6 PF18452.1 KII73097.1 - 0.0036 16.8 0.0 0.021 14.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 KII73097.1 - 0.0043 17.2 0.3 0.068 13.4 0.0 2.4 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 KII73097.1 - 0.0078 16.4 0.1 0.33 11.1 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Izumo-Ig PF16706.5 KII73097.1 - 0.14 12.2 0.1 2.6 8.2 0.0 2.4 2 1 0 2 2 2 0 Izumo-like Immunoglobulin domain CHB_HEX PF03173.13 KII73098.1 - 0.086 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative carbohydrate binding domain Pkinase PF00069.25 KII73101.1 - 3.9e-66 223.1 0.8 4.7e-66 222.9 0.1 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII73101.1 - 3.2e-39 134.8 0.0 4.9e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KII73101.1 - 9.8e-06 25.1 0.0 3.4e-05 23.3 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 KII73101.1 - 0.0023 17.3 0.0 0.0051 16.2 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII73101.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family aGPT-Pplase3 PF18746.1 KII73103.1 - 0.015 14.6 2.2 0.018 14.4 2.2 1.1 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 FTR_C PF02741.15 KII73103.1 - 0.091 12.8 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 FTR, proximal lobe PGAP1 PF07819.13 KII73104.1 - 0.0075 16.0 0.0 0.0075 16.0 0.0 1.1 1 0 0 1 1 1 1 PGAP1-like protein LytR_cpsA_psr PF03816.14 KII73104.1 - 0.054 13.7 0.0 0.066 13.4 0.0 1.1 1 0 0 1 1 1 0 Cell envelope-related transcriptional attenuator domain Serpin PF00079.20 KII73105.1 - 1.1e-69 235.5 3.8 1.3e-69 235.3 3.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) UPF0158 PF03682.13 KII73105.1 - 0.034 14.1 2.0 1.2 9.1 0.0 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0158) LIAS_N PF16881.5 KII73105.1 - 0.15 12.5 0.1 2.3 8.7 0.0 2.3 2 0 0 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family Fra10Ac1 PF09725.9 KII73106.1 - 0.029 14.4 0.2 0.042 13.9 0.2 1.3 1 0 0 1 1 1 0 Folate-sensitive fragile site protein Fra10Ac1 AltA1 PF16541.5 KII73106.1 - 0.12 13.2 4.7 0.13 13.2 2.3 2.0 1 1 1 2 2 2 0 Alternaria alternata allergen 1 bacHORMA_2 PF18173.1 KII73107.1 - 0.21 11.5 0.1 0.29 11.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial HORMA domain 2 MLVIN_C PF18697.1 KII73110.1 - 0.00036 20.6 0.0 0.00091 19.3 0.0 1.7 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Retrotrans_gag PF03732.17 KII73110.1 - 0.0048 17.1 0.2 0.011 15.9 0.2 1.7 1 1 0 1 1 1 1 Retrotransposon gag protein DUF4219 PF13961.6 KII73110.1 - 0.15 11.8 3.7 2.3 8.0 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) RPAP3_C PF13877.6 KII73110.1 - 0.16 12.5 0.6 0.81 10.3 0.2 2.1 1 1 0 2 2 2 0 Potential Monad-binding region of RPAP3 RT_RNaseH_2 PF17919.1 KII73111.1 - 4e-35 119.8 0.1 8.9e-35 118.7 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII73111.1 - 1.6e-24 86.2 0.0 3.5e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII73111.1 - 1.9e-19 70.1 0.0 4.4e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII73111.1 - 3.4e-07 30.7 0.0 7e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII73111.1 - 1.5e-05 25.5 0.0 4e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII73111.1 - 0.0026 18.0 0.1 0.0065 16.8 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII73111.1 - 0.035 13.9 0.0 0.092 12.5 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.6 KII73111.1 - 0.089 12.5 3.7 0.26 11.0 3.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger F-box PF00646.33 KII73114.1 - 0.017 15.0 0.3 0.15 12.0 0.0 2.5 2 0 0 2 2 2 0 F-box domain LRR_1 PF00560.33 KII73114.1 - 0.43 11.3 7.1 54 4.9 0.4 4.6 4 1 0 4 4 4 0 Leucine Rich Repeat SNAP PF14938.6 KII73115.1 - 1.9e-08 34.1 0.4 2.6e-08 33.7 0.4 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP BORCS6 PF10157.9 KII73115.1 - 0.0049 17.1 0.2 0.0069 16.6 0.2 1.2 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 TPR_MalT PF17874.1 KII73115.1 - 0.17 11.2 0.0 0.22 10.8 0.0 1.1 1 0 0 1 1 1 0 MalT-like TPR region Ca_bind_SSO6904 PF18249.1 KII73115.1 - 0.92 9.9 5.0 0.48 10.8 0.4 2.5 1 1 0 2 2 2 0 Calcium binding protein SSO6904 RT_RNaseH_2 PF17919.1 KII73120.1 - 8.8e-35 118.7 0.1 2.1e-34 117.5 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII73120.1 - 3.2e-24 85.2 0.0 7.7e-24 84.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII73120.1 - 1.5e-19 70.4 0.0 3.5e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII73120.1 - 2.7e-07 31.0 0.0 5.8e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII73120.1 - 1.2e-05 25.8 0.0 3.3e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII73120.1 - 0.002 18.4 0.1 0.0054 17.0 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII73120.1 - 0.027 14.3 0.0 0.075 12.8 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.6 KII73120.1 - 0.074 12.8 3.7 0.22 11.2 3.7 1.8 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Latrotoxin_C PF15658.6 KII73123.1 - 0.32 10.7 4.8 3.7 7.3 0.4 2.7 1 1 1 2 2 2 0 Latrotoxin C-terminal domain CcmH PF03918.14 KII73124.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Exonuc_VIII PF06630.11 KII73126.1 - 0.0081 16.0 0.1 0.0086 16.0 0.1 1.1 1 0 0 1 1 1 1 Enterobacterial exodeoxyribonuclease VIII Mucin PF01456.17 KII73126.1 - 0.18 11.8 5.9 0.23 11.4 5.9 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Amidohydro_2 PF04909.14 KII73128.1 - 7.1e-37 127.8 0.0 8.9e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Exonuc_VII_L PF02601.15 KII73128.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LysR_substrate PF03466.20 KII73129.1 - 2.8e-11 43.2 0.4 3.3e-11 43.0 0.4 1.0 1 0 0 1 1 1 1 LysR substrate binding domain Ldl_recept_a PF00057.18 KII73130.1 - 0.0017 18.5 2.3 0.003 17.7 2.3 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A RVT_1 PF00078.27 KII73132.1 - 4.1e-05 23.2 0.5 7e-05 22.4 0.5 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pou PF00157.17 KII73132.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain Ldl_recept_a PF00057.18 KII73135.1 - 1.2e-26 92.6 70.7 7e-10 39.0 16.7 4.4 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A Glycos_transf_2 PF00535.26 KII73136.1 - 2.9e-24 85.8 0.0 5.3e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 KII73136.1 - 1e-18 67.8 1.4 1.2e-08 34.8 0.1 2.5 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 KII73136.1 - 1.5e-12 47.9 0.0 3.9e-12 46.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_1 PF00534.20 KII73136.1 - 3.1e-11 43.1 0.2 1.1e-08 34.9 0.1 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KII73136.1 - 6.8e-09 36.3 0.0 5.2e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KII73136.1 - 1.6e-08 34.7 0.0 6.1e-08 32.8 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_transf_7C PF02709.14 KII73136.1 - 2.8e-05 23.7 0.1 6.5e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_trans_4_4 PF13579.6 KII73136.1 - 0.00036 21.0 0.0 0.0013 19.2 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 KII73136.1 - 0.00065 19.5 0.2 0.075 12.7 0.0 2.6 1 1 1 2 2 2 1 Starch synthase catalytic domain Glyco_transf_21 PF13506.6 KII73136.1 - 0.0078 15.7 0.0 0.02 14.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 KII73136.1 - 0.018 15.0 0.0 0.046 13.6 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferase family group 2 VraX PF17412.2 KII73136.1 - 0.072 12.7 0.5 0.53 10.0 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function PS_pyruv_trans PF04230.13 KII73137.1 - 2.9e-12 47.1 0.4 8.9e-12 45.5 0.4 1.7 1 1 0 1 1 1 1 Polysaccharide pyruvyl transferase Sugar_tr PF00083.24 KII73139.1 - 4.6e-44 151.0 5.1 5.5e-44 150.8 5.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KII73139.1 - 7e-20 71.3 12.2 9.4e-20 70.8 12.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily GidB PF02527.15 KII73140.1 - 0.044 13.1 0.2 0.05 12.9 0.2 1.1 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Orn_Arg_deC_N PF02784.16 KII73141.1 - 4.6e-39 134.3 0.0 1.5e-38 132.6 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KII73141.1 - 0.0012 19.0 0.0 0.0016 18.7 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Phage_fiber PF03335.13 KII73142.1 - 0.46 10.8 0.2 0.46 10.8 0.2 2.7 3 0 0 3 3 3 0 Phage tail fibre repeat Mor PF08765.11 KII73143.1 - 0.0091 16.0 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 Mor transcription activator family OSCP PF00213.18 KII73143.1 - 0.02 15.0 0.0 0.031 14.4 0.0 1.2 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit R3H PF01424.22 KII73144.1 - 0.0085 16.1 1.1 0.065 13.2 0.2 2.8 3 0 0 3 3 3 1 R3H domain DUF4158 PF13700.6 KII73144.1 - 0.054 13.3 0.1 0.13 12.1 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4158) HTH_6 PF01418.17 KII73144.1 - 2.6 8.1 4.4 12 5.9 0.3 3.5 3 2 2 5 5 5 0 Helix-turn-helix domain, rpiR family Smr PF01713.21 KII73147.1 - 0.00043 20.6 0.0 0.00064 20.0 0.0 1.2 1 0 0 1 1 1 1 Smr domain Agarase_CBM PF17992.1 KII73152.1 - 0.084 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Agarase CBM like domain DUF202 PF02656.15 KII73155.1 - 0.23 11.9 2.5 0.39 11.2 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) PMP22_Claudin PF00822.20 KII73156.1 - 0.0015 18.4 0.6 0.0026 17.7 0.6 1.5 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF3040 PF11239.8 KII73156.1 - 0.071 13.4 1.3 0.17 12.2 1.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF2157 PF09925.9 KII73156.1 - 0.41 10.4 4.6 1.9 8.3 4.6 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) Chordopox_A13L PF05961.11 KII73156.1 - 0.41 10.9 3.3 0.33 11.2 0.6 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein DUF2627 PF11118.8 KII73156.1 - 1.2 9.7 5.5 1.4 9.5 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) PMP22_Claudin PF00822.20 KII73158.1 - 0.0015 18.4 0.6 0.0026 17.7 0.6 1.5 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF3040 PF11239.8 KII73158.1 - 0.071 13.4 1.3 0.17 12.2 1.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF2157 PF09925.9 KII73158.1 - 0.41 10.4 4.6 1.9 8.3 4.6 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) Chordopox_A13L PF05961.11 KII73158.1 - 0.41 10.9 3.3 0.33 11.2 0.6 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein DUF2627 PF11118.8 KII73158.1 - 1.2 9.7 5.5 1.4 9.5 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) RelA_SpoT PF04607.17 KII73159.1 - 0.099 12.9 2.7 0.6 10.4 0.9 2.2 2 0 0 2 2 2 0 Region found in RelA / SpoT proteins DUF2951 PF11166.8 KII73159.1 - 0.91 9.8 4.8 7.2 6.9 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Glycos_transf_2 PF00535.26 KII73160.1 - 0.0021 17.9 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 KII73160.1 - 0.029 14.3 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family group 2 PHB_acc_N PF07879.11 KII73161.1 - 0.0026 17.8 0.1 0.0059 16.7 0.1 1.6 1 0 0 1 1 1 1 PHB/PHA accumulation regulator DNA-binding domain DDE_3 PF13358.6 KII73163.1 - 8.7e-12 45.0 0.5 1e-11 44.8 0.5 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease FERM_N_2 PF18038.1 KII73163.1 - 0.043 14.7 0.1 0.45 11.4 0.0 2.1 2 0 0 2 2 2 0 FERM N-terminal domain AroM PF07302.11 KII73163.1 - 0.17 11.3 0.0 0.22 10.9 0.0 1.4 1 1 0 1 1 1 0 AroM protein Flu_C_NS1 PF03506.13 KII73164.1 - 0.15 12.0 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) MMS22L_C PF14911.6 KII73167.1 - 0.0062 15.7 3.6 0.27 10.3 3.4 2.7 1 1 0 1 1 1 1 S-phase genomic integrity recombination mediator, C-terminal TFIID_20kDa PF03847.13 KII73169.1 - 2.8e-14 53.4 1.0 3.6e-14 53.0 1.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A SPACA7 PF15307.6 KII73169.1 - 0.02 15.2 0.0 0.028 14.7 0.0 1.3 1 1 0 1 1 1 0 Sperm acrosome-associated protein 7 CTP_transf_1 PF01148.20 KII73170.1 - 7.4e-55 186.6 25.0 1.3e-54 185.8 25.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase family DUF1125 PF06563.11 KII73170.1 - 0.061 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1125) AAA_23 PF13476.6 KII73172.1 - 0.033 14.7 1.9 0.032 14.7 1.9 1.1 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 KII73173.1 - 7.3e-08 33.0 3.4 0.52 11.3 0.0 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat WD40_like PF17005.5 KII73173.1 - 0.0037 16.6 2.8 0.0059 16.0 2.8 1.3 1 0 0 1 1 1 1 WD40-like domain DUF4571 PF15137.6 KII73173.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4571) ANAPC4_WD40 PF12894.7 KII73173.1 - 0.048 14.0 0.0 30 5.0 0.0 3.5 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SSP160 PF06933.11 KII73174.1 - 0.037 12.3 0.1 0.051 11.8 0.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 fn3 PF00041.21 KII73174.1 - 0.14 12.5 0.0 8 6.9 0.0 3.1 3 0 0 3 3 3 0 Fibronectin type III domain zf-C3HC PF07967.13 KII73175.1 - 7.1e-16 58.5 0.1 8.5e-16 58.2 0.1 1.1 1 0 0 1 1 1 1 C3HC zinc finger-like BTK PF00779.19 KII73175.1 - 0.21 11.4 3.2 0.65 9.9 3.2 1.8 1 0 0 1 1 1 0 BTK motif MT-A70 PF05063.14 KII73176.1 - 3.7e-13 49.7 0.0 1.6e-10 41.2 0.0 2.3 2 1 0 2 2 2 2 MT-A70 DNA_pol_A PF00476.20 KII73176.1 - 0.082 11.9 0.1 0.096 11.7 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase family A TPR_8 PF13181.6 KII73178.1 - 0.0018 18.3 0.9 2.7 8.4 0.1 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KII73178.1 - 0.035 13.8 0.0 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 TPR repeat ANAPC3 PF12895.7 KII73178.1 - 0.052 13.8 0.4 0.33 11.2 0.2 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 IKI3 PF04762.12 KII73179.1 - 7.9e-35 120.2 3.0 9.6e-35 119.9 3.0 1.0 1 0 0 1 1 1 1 IKI3 family IKI3 PF04762.12 KII73180.1 - 4.9e-41 140.7 0.0 5.4e-41 140.6 0.0 1.0 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 KII73180.1 - 0.01 16.1 0.0 1.2 9.5 0.0 3.5 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KII73181.1 - 3.3e-05 24.6 5.2 0.19 12.6 0.0 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat ADD_ATRX PF17981.1 KII73181.1 - 0.044 13.6 0.5 0.95 9.4 0.0 2.5 2 0 0 2 2 2 0 Cysteine Rich ADD domain TBK1_CCD1 PF18394.1 KII73181.1 - 0.18 11.3 0.0 0.34 10.4 0.0 1.4 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 Ribosomal_L22 PF00237.19 KII73182.1 - 0.0013 19.0 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e ACPS PF01648.20 KII73183.1 - 1.1e-06 28.7 0.0 2.5e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Sel1 PF08238.12 KII73184.1 - 3.4e-10 40.2 4.9 0.02 15.6 0.0 5.3 5 0 0 5 5 5 4 Sel1 repeat Pannexin_like PF12534.8 KII73185.1 - 4.7e-07 29.2 1.3 1.8e-05 24.0 0.3 3.2 2 1 1 3 3 3 2 Pannexin-like TM region of LRRC8 DUF4635 PF15466.6 KII73185.1 - 0.02 14.4 1.8 3.1 7.3 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) DUF4197 PF13852.6 KII73186.1 - 0.063 13.0 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4197) Phage_head_fibr PF11133.8 KII73186.1 - 0.091 12.2 0.0 0.13 11.7 0.0 1.3 1 1 0 1 1 1 0 Head fiber protein JMY PF15871.5 KII73187.1 - 0.0031 16.9 1.1 0.0035 16.7 1.1 1.0 1 0 0 1 1 1 1 Junction-mediating and -regulatory protein RE_Alw26IDE PF09665.10 KII73187.1 - 0.025 13.8 0.2 0.028 13.6 0.2 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) Mss4 PF04421.13 KII73187.1 - 0.13 12.4 1.3 0.16 12.1 0.1 1.7 2 0 0 2 2 2 0 Mss4 protein zf-CRD PF17979.1 KII73187.1 - 0.16 12.1 0.9 0.18 11.9 0.9 1.1 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions UPF0122 PF04297.14 KII73187.1 - 1.1 9.5 7.4 1.3 9.3 0.2 2.6 1 1 2 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like zf-MIZ PF02891.20 KII73188.1 - 7.3e-12 44.8 3.1 1.4e-11 44.0 3.1 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KII73188.1 - 0.0006 19.6 2.5 0.0016 18.2 2.5 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 KII73188.1 - 1.3 9.4 8.9 0.31 11.4 5.1 1.9 2 0 0 2 2 2 0 Ring finger domain DDE_Tnp_IS1595 PF12762.7 KII73189.1 - 2.4e-07 30.9 0.0 3.7e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain APG17 PF04108.12 KII73191.1 - 0.0025 17.0 11.1 0.081 12.0 1.0 2.0 1 1 1 2 2 2 2 Autophagy protein Apg17 AAA_13 PF13166.6 KII73191.1 - 0.028 13.1 9.8 0.033 12.8 9.8 1.0 1 0 0 1 1 1 0 AAA domain Rab5-bind PF09311.11 KII73191.1 - 0.029 13.8 14.6 0.53 9.6 3.1 2.0 1 1 1 2 2 2 0 Rabaptin-like protein DUF4743 PF15916.5 KII73191.1 - 0.041 13.8 0.2 0.059 13.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4743) Med30 PF11315.8 KII73191.1 - 0.062 13.5 12.0 0.1 12.8 12.0 1.5 1 1 0 1 1 1 0 Mediator complex subunit 30 BLOC1_2 PF10046.9 KII73191.1 - 0.076 13.3 10.0 0.53 10.6 2.4 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec8_exocyst PF04048.14 KII73191.1 - 0.15 12.0 8.4 0.034 14.0 2.3 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DHR10 PF18595.1 KII73191.1 - 0.41 10.7 13.9 7.2 6.7 13.9 2.2 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain APG6_N PF17675.1 KII73191.1 - 0.77 10.3 12.1 5 7.7 12.1 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF948 PF06103.11 KII73191.1 - 1.4 9.2 3.9 18 5.7 0.9 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Exonuc_VII_L PF02601.15 KII73191.1 - 2.1 7.9 8.2 2.8 7.4 8.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BST2 PF16716.5 KII73191.1 - 6.3 7.5 10.9 2.8 8.6 2.4 2.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DDE_3 PF13358.6 KII73192.1 - 0.023 14.5 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_3 PF13358.6 KII73193.1 - 0.0017 18.1 0.0 0.0023 17.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Med10 PF09748.9 KII73199.1 - 0.053 13.5 0.0 3.8 7.5 0.0 2.1 2 0 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex WD40 PF00400.32 KII73203.1 - 5.7e-20 71.3 8.3 5e-05 24.0 0.1 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII73203.1 - 7.1e-10 39.1 0.6 1.8 8.9 0.1 5.9 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 KII73203.1 - 0.00014 21.4 0.1 0.0003 20.4 0.1 1.6 1 0 0 1 1 1 1 LisH-like dimerisation domain TFIIIC_delta PF12657.7 KII73203.1 - 0.0071 16.3 0.0 0.034 14.1 0.0 2.1 2 0 0 2 2 2 1 Transcription factor IIIC subunit delta N-term eIF2A PF08662.11 KII73203.1 - 0.0081 16.1 0.1 0.046 13.6 0.0 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KII73203.1 - 0.017 14.4 1.5 0.93 8.8 0.3 3.2 1 1 2 4 4 4 0 WD40-like domain EF-hand_1 PF00036.32 KII73205.1 - 1.2e-23 80.8 1.6 1e-05 24.7 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KII73205.1 - 8.1e-23 80.7 0.6 4.9e-11 42.9 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KII73205.1 - 1.9e-19 67.9 1.1 2.2e-06 27.1 0.4 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KII73205.1 - 2.4e-18 65.7 4.0 8.1e-08 32.0 0.0 3.7 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 KII73205.1 - 7e-09 35.9 0.0 0.00018 21.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KII73205.1 - 1.5e-07 30.5 3.4 0.0034 16.8 2.6 3.9 4 0 0 4 4 4 2 EF hand UPF0154 PF03672.13 KII73205.1 - 0.039 14.0 0.0 0.32 11.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) DUF3349 PF11829.8 KII73205.1 - 0.095 13.5 0.1 11 6.9 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) VanY PF02557.17 KII73205.1 - 0.2 11.4 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase PheRS_DBD3 PF18553.1 KII73208.1 - 6.5e-15 55.2 0.1 2e-14 53.6 0.0 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 3 PheRS_DBD1 PF18552.1 KII73208.1 - 4.6e-05 23.1 0.6 7.5e-05 22.4 0.6 1.4 1 0 0 1 1 1 1 PheRS DNA binding domain 1 PheRS_DBD2 PF18554.1 KII73208.1 - 0.00013 21.9 5.1 0.00034 20.5 5.1 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 2 HTH_45 PF14947.6 KII73208.1 - 0.0016 18.4 3.8 0.11 12.5 0.2 2.4 2 0 0 2 2 2 2 Winged helix-turn-helix tRNA-synt_2d PF01409.20 KII73209.1 - 4.6e-49 167.1 0.2 9e-49 166.2 0.2 1.4 1 1 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA_synthFbeta PF17759.1 KII73209.1 - 2.4e-05 23.9 0.0 3.2e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 KII73209.1 - 7.7e-05 21.9 0.1 0.00022 20.4 0.1 1.7 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 KII73209.1 - 0.047 13.6 0.0 0.07 13.1 0.0 1.4 1 1 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) CK_II_beta PF01214.18 KII73212.1 - 0.073 12.9 0.4 0.2 11.4 0.4 1.7 1 0 0 1 1 1 0 Casein kinase II regulatory subunit Herpes_BLRF2 PF05812.12 KII73212.1 - 0.13 12.5 0.2 0.26 11.4 0.2 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein WD40 PF00400.32 KII73213.1 - 0.0051 17.6 5.9 0.13 13.1 0.2 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat PHO4 PF01384.20 KII73216.1 - 3.7e-81 272.8 10.4 5.7e-81 272.2 10.4 1.3 1 1 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.10 KII73216.1 - 0.0089 15.8 0.3 2 8.3 0.1 2.8 2 1 0 2 2 2 2 IclR helix-turn-helix domain PEP-CTERM PF07589.11 KII73216.1 - 3.9 7.7 4.6 2.2 8.5 0.1 3.0 2 0 0 2 2 2 0 PEP-CTERM motif Carb_anhydrase PF00194.21 KII73217.1 - 1.4e-45 155.8 0.2 1.6e-41 142.5 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 KII73218.1 - 1.1e-22 80.8 0.1 1.3e-22 80.6 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 KII73219.1 - 1.2e-24 87.3 0.7 1.3e-24 87.1 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 KII73221.1 - 4.3e-38 131.3 0.1 5e-38 131.1 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Phage_Mu_Gam PF07352.12 KII73222.1 - 0.016 15.1 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein TGF_beta_GS PF08515.12 KII73222.1 - 7.3 6.2 10.5 31 4.2 0.5 4.2 3 0 0 3 3 3 0 Transforming growth factor beta type I GS-motif Carb_anhydrase PF00194.21 KII73223.1 - 4.4e-52 177.1 0.0 6.1e-52 176.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Pyr_redox_dim PF02852.22 KII73225.1 - 2.4e-36 124.3 0.0 3e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 KII73225.1 - 0.0015 17.9 0.0 0.0044 16.3 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase CPG4 PF15481.6 KII73225.1 - 0.086 13.5 0.2 0.16 12.6 0.2 1.3 1 0 0 1 1 1 0 Chondroitin proteoglycan 4 Pyr_redox_2 PF07992.14 KII73226.1 - 1.8e-15 56.9 0.0 2.1e-15 56.7 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KII73226.1 - 4.1e-11 43.3 0.0 6.4e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KII73226.1 - 0.011 15.0 0.1 0.018 14.3 0.1 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KII73226.1 - 0.013 14.8 0.1 0.016 14.5 0.1 1.1 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 KII73226.1 - 0.023 14.9 0.2 0.038 14.2 0.2 1.3 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Ribosomal_L24e PF01246.20 KII73227.1 - 8.2e-31 106.1 0.5 8.2e-31 106.1 0.5 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e XRN_M PF17846.1 KII73227.1 - 0.026 13.5 5.9 0.03 13.3 5.9 1.0 1 0 0 1 1 1 0 Xrn1 helical domain RR_TM4-6 PF06459.12 KII73227.1 - 1.7 8.4 11.6 2 8.2 11.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TPR_8 PF13181.6 KII73228.1 - 0.00096 19.2 1.4 23 5.5 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 KII73228.1 - 0.0067 16.7 0.5 0.33 11.3 0.1 2.9 2 2 1 3 3 3 1 Tetratricopeptide repeat ATP13 PF12921.7 KII73228.1 - 0.013 15.4 0.6 0.91 9.4 0.1 2.5 2 1 0 2 2 2 0 Mitochondrial ATPase expression Ifi-6-16 PF06140.13 KII73228.1 - 0.051 13.5 0.1 0.08 12.9 0.1 1.3 1 0 0 1 1 1 0 Interferon-induced 6-16 family TPR_17 PF13431.6 KII73228.1 - 0.075 13.5 1.2 0.2 12.1 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII73228.1 - 0.1 12.7 0.3 6.1 7.2 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 KII73228.1 - 0.14 12.8 0.3 11 7.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KII73228.1 - 0.31 11.1 1.7 21 5.4 0.1 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ATP-synt_DE_N PF02823.16 KII73229.1 - 1.2e-16 60.4 0.3 1.7e-16 59.9 0.3 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain eIF-5a PF01287.20 KII73229.1 - 0.039 14.1 0.1 0.071 13.2 0.1 1.5 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold DP PF08781.10 KII73231.1 - 7.7e-25 87.4 1.1 1.1e-24 86.8 0.2 1.7 2 0 0 2 2 2 1 Transcription factor DP E2F_TDP PF02319.20 KII73231.1 - 1.6e-24 85.7 0.2 3.7e-24 84.6 0.2 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DUF4320 PF14208.6 KII73231.1 - 0.066 13.3 0.7 3.2 7.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) FeoB_Cyto PF17910.1 KII73231.1 - 0.1 13.2 0.3 0.47 11.0 0.0 2.2 2 1 0 2 2 2 0 FeoB cytosolic helical domain DDE_Tnp_IS1595 PF12762.7 KII73232.1 - 2.3e-12 47.2 0.0 2.8e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain IPP-2 PF04979.14 KII73233.1 - 2.2e-17 64.0 1.9 3.6e-17 63.3 1.9 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) HTH_23 PF13384.6 KII73234.1 - 0.045 13.6 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain RP853 PF17542.2 KII73234.1 - 0.17 11.0 2.2 0.19 10.8 2.2 1.2 1 1 0 1 1 1 0 Uncharacterized RP853 DEAD PF00270.29 KII73235.1 - 3.6e-25 88.7 0.2 3.7e-24 85.4 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII73235.1 - 1.3e-23 83.5 1.0 7e-23 81.1 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII73235.1 - 2.3e-12 47.2 0.2 5.4e-10 39.5 0.0 2.2 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KII73235.1 - 0.00087 19.6 0.0 0.0021 18.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain SNF2_N PF00176.23 KII73235.1 - 0.012 14.4 0.3 0.57 8.8 0.0 2.1 2 0 0 2 2 2 0 SNF2 family N-terminal domain Helicase_C_2 PF13307.6 KII73235.1 - 0.021 15.0 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain AAA PF00004.29 KII73235.1 - 0.21 12.0 1.8 0.76 10.2 0.5 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) tRNA-synt_1c PF00749.21 KII73236.1 - 3e-100 335.2 0.7 4.7e-100 334.5 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KII73236.1 - 2.7e-27 95.7 1.4 5e-27 94.9 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain HGTP_anticodon PF03129.20 KII73236.1 - 4e-19 68.6 0.0 1.2e-18 67.0 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KII73236.1 - 2.1e-18 66.9 0.0 8e-18 65.0 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) ProRS-C_1 PF09180.11 KII73236.1 - 6.2e-17 61.6 1.1 6.2e-17 61.6 1.1 2.2 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal GST_C PF00043.25 KII73236.1 - 0.00018 21.6 0.0 0.00058 20.0 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KII73236.1 - 0.087 13.0 0.0 0.61 10.3 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Mito_carr PF00153.27 KII73239.1 - 2.1e-55 184.6 6.2 2.1e-23 82.0 0.3 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein PLAC8 PF04749.17 KII73240.1 - 1.2e-21 77.6 9.9 1.3e-21 77.4 9.9 1.0 1 0 0 1 1 1 1 PLAC8 family DUF5376 PF17346.2 KII73241.1 - 0.021 15.2 0.7 0.45 10.9 0.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5376) DUF1240 PF06836.12 KII73241.1 - 0.12 12.9 2.4 0.32 11.5 2.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1240) Tmemb_9 PF05434.11 KII73241.1 - 0.15 12.0 1.9 0.26 11.2 1.9 1.3 1 0 0 1 1 1 0 TMEM9 SRF-TF PF00319.18 KII73242.1 - 3.9e-21 74.3 0.2 6.4e-21 73.6 0.2 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DNA_gyraseA_C PF03989.13 KII73242.1 - 0.14 11.7 0.3 0.44 10.1 0.0 1.9 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller Ion_trans PF00520.31 KII73243.1 - 4.6e-08 32.6 0.9 4.6e-08 32.6 0.9 1.6 2 0 0 2 2 2 1 Ion transport protein Ldl_recept_a PF00057.18 KII73244.1 - 9.4e-10 38.5 11.9 2.9e-09 37.0 11.9 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A NUP214 PF16755.5 KII73244.1 - 0.019 14.2 0.8 0.019 14.2 0.8 2.2 1 1 1 2 2 2 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 PrgI PF12666.7 KII73245.1 - 8.2e-05 23.2 1.1 0.00011 22.8 1.1 1.2 1 0 0 1 1 1 1 PrgI family protein Ribosomal_L2 PF00181.23 KII73246.1 - 1.2e-16 60.5 0.1 3.4e-16 59.0 0.1 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C PF03947.18 KII73246.1 - 6.9e-13 48.9 0.1 1.5e-12 47.8 0.0 1.6 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain ALMT PF11744.8 KII73247.1 - 1 8.1 5.8 1 8.1 5.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter SelP_N PF04592.14 KII73247.1 - 2.7 7.3 10.8 3 7.2 10.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 KII73247.1 - 2.8 6.6 5.7 3.2 6.4 5.7 1.0 1 0 0 1 1 1 0 Presenilin FGF-BP1 PF06473.12 KII73247.1 - 9.6 6.0 12.5 12 5.7 12.5 1.0 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Ribosomal_S17 PF00366.20 KII73248.1 - 0.00067 19.7 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Dev_Cell_Death PF10539.9 KII73250.1 - 0.09 12.6 0.0 0.094 12.6 0.0 1.1 1 0 0 1 1 1 0 Development and cell death domain Ribosomal_L16 PF00252.18 KII73251.1 - 1.5e-06 28.3 0.0 2.6e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L16p/L10e HTH_45 PF14947.6 KII73251.1 - 0.075 13.0 0.2 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix BSD PF03909.17 KII73252.1 - 0.0036 17.3 0.8 0.0096 15.9 0.0 2.1 2 1 1 3 3 3 1 BSD domain Proteasome PF00227.26 KII73255.1 - 4.5e-32 111.1 0.0 5.1e-32 110.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Aldolase_II PF00596.21 KII73256.1 - 8e-21 74.8 0.0 2.4e-20 73.2 0.0 1.7 2 0 0 2 2 2 1 Class II Aldolase and Adducin N-terminal domain Kelch_5 PF13854.6 KII73257.1 - 7.2e-19 67.4 1.7 2.6e-08 33.7 0.1 4.4 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 KII73257.1 - 7.6e-18 64.1 5.1 8.1e-05 22.8 0.0 5.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII73257.1 - 8.7e-15 54.5 6.5 0.00053 19.9 0.0 5.3 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73257.1 - 1.4e-10 40.5 10.5 0.00089 18.8 0.5 5.5 5 1 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII73257.1 - 1.9e-10 40.7 3.2 0.022 15.1 0.0 5.7 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII73257.1 - 0.00031 20.6 10.0 0.64 10.1 0.0 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 KII73258.1 - 1e-22 79.8 7.8 0.0002 21.3 0.0 5.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 KII73258.1 - 3.4e-22 77.9 10.9 2.3e-05 24.5 0.0 6.8 6 1 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KII73258.1 - 4.4e-22 77.4 17.7 1e-05 25.0 0.1 6.6 6 1 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 KII73258.1 - 1.9e-14 53.2 7.2 9.2e-06 25.5 0.1 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII73258.1 - 8.9e-13 48.2 7.6 0.021 15.1 0.0 6.5 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KII73258.1 - 1.8e-09 37.2 16.4 0.064 13.3 0.3 6.6 7 0 0 7 7 7 4 Kelch motif DUF1071 PF06378.11 KII73258.1 - 0.021 14.4 0.0 0.043 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Kelch_4 PF13418.6 KII73259.1 - 0.094 12.7 0.2 5.6 7.1 0.1 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_4 PF13418.6 KII73260.1 - 2e-14 53.3 0.7 0.0013 18.7 0.1 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KII73260.1 - 2.4e-11 43.5 9.5 7.3e-05 22.9 0.1 3.7 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII73260.1 - 1.3e-09 37.9 8.0 9.2e-06 25.5 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII73260.1 - 7e-07 29.4 6.0 0.001 19.3 0.2 3.6 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73260.1 - 1.7e-06 27.5 12.9 0.0037 16.8 0.4 3.5 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII73260.1 - 0.0028 17.5 9.8 0.013 15.4 0.1 3.4 2 2 1 3 3 3 1 Kelch motif DUF2689 PF10894.8 KII73260.1 - 0.09 12.6 2.3 8 6.3 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2689) Kelch_6 PF13964.6 KII73261.1 - 2.8e-10 40.1 2.3 4.4e-05 23.6 0.1 3.7 2 1 1 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII73261.1 - 5.2e-07 29.5 1.7 6.2e-05 22.9 0.1 2.7 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII73261.1 - 7.3e-07 29.1 1.2 1.4e-05 24.9 0.1 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73261.1 - 9.3e-07 28.3 4.7 4e-05 23.1 0.1 3.3 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 KII73261.1 - 6.3e-06 26.0 1.3 0.0098 15.8 0.7 2.9 2 1 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII73261.1 - 0.0032 17.7 0.0 4 7.8 0.0 2.8 3 0 0 3 3 3 2 Galactose oxidase, central domain SspH PF08141.12 KII73261.1 - 0.064 13.4 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 Small acid-soluble spore protein H family Rabaptin PF03528.15 KII73262.1 - 0.00018 20.4 1.4 0.00029 19.7 1.4 1.4 1 0 0 1 1 1 1 Rabaptin Cep57_MT_bd PF06657.13 KII73262.1 - 0.055 13.9 0.2 0.055 13.9 0.2 2.8 2 2 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF2550 PF10739.9 KII73262.1 - 0.23 11.5 0.0 0.31 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2550) SEP PF08059.13 KII73263.1 - 7.5e-12 45.7 0.1 1.6e-11 44.6 0.1 1.5 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.6 KII73263.1 - 2e-05 24.3 0.2 3.3e-05 23.6 0.2 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 KII73263.1 - 0.018 14.7 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 TAP C-terminal domain Sortilin_C PF15901.5 KII73264.1 - 7.4e-19 68.7 3.6 1.4e-18 67.8 3.6 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII73264.1 - 1.1e-08 34.4 0.2 0.0031 16.3 0.2 2.4 2 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII73264.1 - 0.027 14.4 0.8 3.5 8.0 0.0 3.4 3 0 0 3 3 3 0 BNR/Asp-box repeat Glyco_transf_54 PF04666.13 KII73265.1 - 0.11 11.4 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Homeodomain PF00046.29 KII73266.1 - 7.9e-19 67.3 3.4 1.2e-18 66.6 3.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KII73266.1 - 0.086 12.8 0.2 0.26 11.2 0.2 1.8 1 0 0 1 1 1 0 Homeobox KN domain SurA_N_3 PF13624.6 KII73268.1 - 0.013 15.3 0.0 0.34 10.7 0.0 2.0 1 1 0 2 2 2 0 SurA N-terminal domain DDE_3 PF13358.6 KII73270.1 - 7.3e-28 97.2 0.0 1.2e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.11 KII73270.1 - 9.5e-05 21.5 0.8 0.07 12.1 0.1 2.4 3 0 0 3 3 3 2 Rhodopirellula transposase DDE domain HTH_23 PF13384.6 KII73270.1 - 0.00014 21.6 0.3 0.0053 16.5 0.1 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 KII73270.1 - 0.0012 18.9 0.1 0.0025 17.9 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain rve PF00665.26 KII73270.1 - 0.0031 17.7 0.0 0.0066 16.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_5 PF01022.20 KII73270.1 - 0.0036 17.1 0.3 0.018 14.9 0.1 2.3 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_Tnp_Tc3_2 PF01498.18 KII73270.1 - 0.011 16.0 0.1 0.03 14.6 0.1 1.8 1 0 0 1 1 1 0 Transposase HTH_Tnp_1 PF01527.20 KII73270.1 - 0.045 14.1 0.3 0.27 11.6 0.0 2.2 2 0 0 2 2 2 0 Transposase YflT PF11181.8 KII73270.1 - 0.049 14.1 0.3 0.51 10.9 0.0 2.4 2 0 0 2 2 2 0 Heat induced stress protein YflT MFS_1 PF07690.16 KII73271.1 - 3.2e-36 125.0 43.8 2.3e-33 115.6 29.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KII73271.1 - 2e-05 24.1 0.4 2e-05 24.1 0.4 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MULE PF10551.9 KII73272.1 - 1.3e-15 57.5 0.4 3.2e-15 56.3 0.2 1.8 2 0 0 2 2 2 1 MULE transposase domain HU-CCDC81_euk_1 PF14908.6 KII73272.1 - 0.09 12.9 0.1 0.29 11.3 0.1 1.8 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 DDE_3 PF13358.6 KII73273.1 - 1.3e-12 47.7 0.1 1.9e-12 47.1 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease BRO1 PF03097.18 KII73273.1 - 0.17 10.7 0.2 0.24 10.2 0.2 1.1 1 0 0 1 1 1 0 BRO1-like domain MRP-L27 PF09809.9 KII73275.1 - 2.1e-08 34.0 0.7 3.1e-08 33.4 0.7 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L27 Ca_hom_mod PF14798.6 KII73276.1 - 0.014 14.5 1.4 0.021 13.9 1.4 1.4 1 1 0 1 1 1 0 Calcium homeostasis modulator AC_N PF16214.5 KII73276.1 - 0.34 10.0 1.3 0.37 9.9 1.3 1.0 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region PetM PF08041.11 KII73276.1 - 2.1 8.0 6.1 0.8 9.3 1.3 2.5 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 Glyco_hydro_108 PF05838.12 KII73277.1 - 0.036 14.6 0.0 5.7 7.5 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase 108 zf-CRD PF17979.1 KII73277.1 - 1.1 9.4 4.0 0.82 9.8 1.6 1.7 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions Filament PF00038.21 KII73279.1 - 0.00014 21.6 12.3 0.00017 21.3 12.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein IMD PF08397.11 KII73279.1 - 0.018 14.4 9.9 0.023 14.1 9.9 1.1 1 0 0 1 1 1 0 IRSp53/MIM homology domain FAM76 PF16046.5 KII73279.1 - 0.2 11.0 10.4 0.23 10.8 10.4 1.1 1 0 0 1 1 1 0 FAM76 protein Phe_tRNA-synt_N PF02912.18 KII73279.1 - 0.52 10.3 6.6 1.4 8.9 2.4 2.3 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain MRPL52 PF18699.1 KII73279.1 - 0.72 10.1 13.7 0.63 10.3 3.0 2.8 1 1 2 3 3 3 0 Mitoribosomal protein mL52 TMF_DNA_bd PF12329.8 KII73279.1 - 0.75 9.8 17.3 0.78 9.8 3.4 3.0 1 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF2203 PF09969.9 KII73279.1 - 1.5 9.6 6.8 0.7 10.6 1.0 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) TMPIT PF07851.13 KII73279.1 - 1.6 7.9 9.1 1.9 7.7 9.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein APG6_N PF17675.1 KII73279.1 - 2.6 8.6 13.8 7.9 7.0 12.2 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF3450 PF11932.8 KII73279.1 - 4.2 6.6 11.6 5.3 6.3 8.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 KII73279.1 - 6.7 6.0 8.4 2 7.7 1.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec1 PF00995.23 KII73280.1 - 1.7e-65 222.4 9.2 2.3e-65 222.0 9.2 1.2 1 0 0 1 1 1 1 Sec1 family Cas_Cas1 PF01867.16 KII73280.1 - 0.018 14.2 0.4 0.031 13.4 0.4 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas1 DrrA_P4M PF14860.6 KII73280.1 - 0.092 12.6 5.0 0.23 11.3 2.3 2.6 2 0 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain ESM4 PF15952.5 KII73280.1 - 0.12 12.8 5.4 0.19 12.1 5.4 1.3 1 0 0 1 1 1 0 Enhancer of split M4 family DUF1722 PF08349.11 KII73280.1 - 0.51 10.6 3.7 0.85 9.9 1.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1722) DASH_Dam1 PF08653.10 KII73280.1 - 2.6 7.9 4.7 12 5.7 0.3 3.4 3 1 1 4 4 4 0 DASH complex subunit Dam1 ALMT PF11744.8 KII73280.1 - 2.8 6.6 6.5 4 6.2 6.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Syntaxin_2 PF14523.6 KII73280.1 - 7.6 7.0 11.4 2.2 8.7 5.8 2.8 3 1 0 3 3 3 0 Syntaxin-like protein RRM_7 PF16367.5 KII73281.1 - 1.3e-10 41.2 0.0 2.8e-08 33.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_1 PF00076.22 KII73281.1 - 2.4e-08 33.7 0.2 0.0017 18.1 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANF_receptor PF01094.28 KII73281.1 - 0.0028 16.8 0.0 0.0038 16.4 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region tRNA-synt_1e PF01406.19 KII73283.1 - 3.9e-27 95.4 0.6 5.1e-27 95.0 0.6 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 KII73283.1 - 0.015 14.1 0.0 0.019 13.7 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KII73283.1 - 0.034 12.4 0.0 0.043 12.1 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 KII73284.1 - 8.4e-31 107.4 1.0 1.1e-30 107.0 1.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 KII73284.1 - 0.0063 15.3 0.1 0.0079 15.0 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) DUF3827 PF12877.7 KII73285.1 - 0.0089 14.5 1.6 0.012 14.0 1.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) Podoplanin PF05808.11 KII73285.1 - 0.016 15.4 0.1 0.025 14.7 0.1 1.4 1 0 0 1 1 1 0 Podoplanin Collectrin PF16959.5 KII73285.1 - 0.03 14.1 0.3 0.048 13.4 0.3 1.5 1 0 0 1 1 1 0 Renal amino acid transporter SCF PF02404.15 KII73285.1 - 0.055 12.8 0.7 0.18 11.1 0.1 1.8 1 1 1 2 2 2 0 Stem cell factor EphA2_TM PF14575.6 KII73285.1 - 0.9 10.5 3.8 14 6.6 2.9 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Insulin_TMD PF17870.1 KII73285.1 - 3.2 7.9 10.3 0.13 12.4 4.5 1.7 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment zf-B_box PF00643.24 KII73286.1 - 0.014 15.5 0.8 0.019 15.1 0.8 1.2 1 0 0 1 1 1 0 B-box zinc finger zf-NADH-PPase PF09297.11 KII73286.1 - 3.9 7.2 8.2 14 5.4 1.8 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain RT_RNaseH PF17917.1 KII73289.1 - 8.2e-35 119.3 0.1 1.9e-34 118.1 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII73289.1 - 4e-25 87.7 0.1 1.2e-24 86.2 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII73289.1 - 1.2e-21 76.5 0.5 3e-21 75.3 0.5 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII73289.1 - 7.2e-21 74.6 0.0 2.1e-20 73.1 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII73289.1 - 0.00047 20.3 0.0 0.0012 19.0 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII73289.1 - 0.016 15.0 1.6 0.036 13.8 0.0 2.4 3 0 0 3 3 3 0 Integrase core domain IBP39 PF11422.8 KII73289.1 - 0.036 13.8 0.7 0.07 12.9 0.7 1.6 1 0 0 1 1 1 0 Initiator binding protein 39 kDa MLVIN_C PF18697.1 KII73289.1 - 0.16 12.1 0.3 3.8 7.7 0.0 2.8 2 1 0 2 2 2 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVT_1 PF00078.27 KII73290.1 - 3.1e-26 92.3 0.7 4.1e-26 91.9 0.7 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MATalpha_HMGbox PF04769.12 KII73290.1 - 0.13 11.6 0.2 0.2 10.9 0.1 1.4 1 1 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box SNAP PF14938.6 KII73295.1 - 7.5e-15 55.1 4.0 1e-14 54.6 3.7 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KII73295.1 - 0.27 11.5 8.1 0.89 9.9 0.1 4.7 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII73295.1 - 0.66 9.9 7.1 93 3.1 0.0 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat DUF4808 PF16066.5 KII73298.1 - 0.084 13.4 0.2 0.79 10.3 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4808) DDE_1 PF03184.19 KII73299.1 - 0.0044 16.7 0.0 0.006 16.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 KII73302.1 - 2.5e-08 33.8 0.0 0.0047 16.7 0.0 3.1 1 1 2 3 3 3 3 DDE superfamily endonuclease Rad60-SLD_2 PF13881.6 KII73303.1 - 0.064 13.4 0.0 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like DSRB PF10781.9 KII73305.1 - 0.024 14.3 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Dextransucrase DSRB rve PF00665.26 KII73306.1 - 1.1e-21 77.2 0.0 1.8e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII73306.1 - 9.8e-14 51.2 0.2 2.4e-13 49.9 0.2 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII73306.1 - 3.7e-05 23.8 0.1 8.9e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 KII73306.1 - 0.00018 21.1 0.0 0.00039 20.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 KII73306.1 - 0.0024 17.6 0.0 0.0067 16.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain CaATP_NAI PF12515.8 KII73306.1 - 0.071 12.7 0.1 15 5.3 0.1 2.7 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain UN_NPL4 PF11543.8 KII73306.1 - 0.08 13.4 0.1 0.6 10.6 0.1 2.3 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 DUF3404 PF11884.8 KII73306.1 - 0.13 11.5 0.0 0.26 10.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) Spheroidin PF05541.12 KII73307.1 - 0.12 10.2 0.5 0.13 10.1 0.5 1.1 1 0 0 1 1 1 0 Entomopoxvirus spheroidin protein CZB PF13682.6 KII73309.1 - 0.14 12.6 0.5 0.31 11.5 0.5 1.6 1 1 0 1 1 1 0 Chemoreceptor zinc-binding domain DnaJ PF00226.31 KII73310.1 - 6.1e-19 67.9 2.0 6.1e-19 67.9 2.0 2.1 2 0 0 2 2 2 1 DnaJ domain Holin_BhlA PF10960.8 KII73310.1 - 3.7 7.6 11.8 1.2 9.1 4.0 3.4 2 1 1 3 3 3 0 BhlA holin family zf-P11 PF03854.14 KII73311.1 - 0.023 14.4 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 P-11 zinc finger Transglut_N PF00868.20 KII73313.1 - 0.00045 20.5 0.1 0.00056 20.2 0.1 1.1 1 0 0 1 1 1 1 Transglutaminase family Exo_endo_phos_2 PF14529.6 KII73318.1 - 2.6e-05 24.0 0.8 4e-05 23.4 0.2 1.6 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RT_RNaseH PF17917.1 KII73320.1 - 3.2e-32 110.9 0.3 5.3e-31 107.0 0.0 2.4 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII73320.1 - 7.7e-26 90.0 0.0 2e-25 88.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII73320.1 - 1.5e-22 80.1 0.0 3.1e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII73320.1 - 1.2e-18 66.9 0.8 2.9e-18 65.7 0.8 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_Tnp_IS240 PF13610.6 KII73320.1 - 0.0013 19.0 0.4 0.018 15.3 0.0 2.8 3 0 0 3 3 3 1 DDE domain zf-H2C2 PF09337.10 KII73320.1 - 0.0017 18.5 0.2 0.011 15.9 0.0 2.5 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII73320.1 - 0.0028 17.4 0.5 0.011 15.6 0.0 2.3 3 0 0 3 3 3 1 Integrase core domain DUF2635 PF10948.8 KII73323.1 - 0.13 12.0 0.0 0.33 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2635) DUF5426 PF17473.2 KII73327.1 - 0.037 14.3 3.8 3.6 7.9 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5426) DUF512 PF04459.12 KII73329.1 - 0.15 11.3 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF512) UCH PF00443.29 KII73330.1 - 7.1e-47 160.1 6.6 1e-46 159.6 6.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Stc1 PF12898.7 KII73330.1 - 0.09 13.3 3.5 1.1 9.9 0.3 3.6 3 0 0 3 3 3 0 Stc1 domain zf-AD PF07776.15 KII73330.1 - 3.9 7.8 10.7 0.47 10.7 0.3 3.4 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) Abhydrolase_1 PF00561.20 KII73331.1 - 1.5e-05 24.8 0.0 0.0023 17.6 0.0 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 KII73331.1 - 0.039 13.8 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 KII73331.1 - 0.16 12.5 0.0 0.26 11.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DLH PF01738.18 KII73331.1 - 0.23 11.0 0.0 0.39 10.2 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Microtub_bd PF16796.5 KII73332.1 - 0.011 15.6 0.0 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Microtubule binding CPBP PF02517.16 KII73332.1 - 0.13 12.6 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 CPBP intramembrane metalloprotease DUF4371 PF14291.6 KII73333.1 - 0.0059 16.3 0.4 0.011 15.3 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) PRKCSH PF07915.13 KII73334.1 - 1e-07 32.8 0.6 2.4e-07 31.6 0.6 1.7 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 KII73334.1 - 2.9e-06 27.1 0.3 6.1e-06 26.0 0.3 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein DUF1030 PF06270.11 KII73334.1 - 0.13 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1030) Big_3_4 PF13754.6 KII73335.1 - 0.079 12.7 0.2 0.23 11.2 0.2 1.7 1 1 1 2 2 2 0 Domain of unknown function ThiF PF00899.21 KII73336.1 - 1.3e-87 293.3 0.0 4.4e-66 222.7 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KII73336.1 - 8.4e-65 219.2 0.5 1.3e-64 218.6 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 KII73336.1 - 1.1e-26 92.8 0.1 3.6e-26 91.2 0.1 2.0 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 KII73336.1 - 2.4e-21 75.7 0.3 8.4e-21 73.9 0.3 2.0 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.10 KII73336.1 - 9.5e-19 67.9 0.0 2.3e-18 66.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain Plasmod_dom_1 PF09715.10 KII73336.1 - 0.029 14.4 0.8 12 6.1 0.1 2.7 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) Glyco_hydro_15 PF00723.21 KII73340.1 - 0.00031 19.6 0.0 0.00036 19.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Glyco_hydro_15 PF00723.21 KII73341.1 - 3.5e-19 68.9 0.3 5.8e-16 58.3 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 15 Ribosomal_S8e PF01201.22 KII73344.1 - 2.6e-14 53.5 0.0 4.1e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e SHS2_FTSA PF02491.20 KII73345.1 - 0.026 14.9 0.0 0.047 14.1 0.0 1.5 1 0 0 1 1 1 0 SHS2 domain inserted in FTSA Intron_maturas2 PF01348.21 KII73345.1 - 0.049 13.6 1.1 0.081 12.9 1.1 1.6 1 1 0 1 1 1 0 Type II intron maturase zf-CCHC_6 PF15288.6 KII73346.1 - 0.12 12.3 0.4 0.23 11.3 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle zinc_ribbon_2 PF13240.6 KII73346.1 - 0.63 9.8 3.3 1.4 8.7 3.3 1.6 1 0 0 1 1 1 0 zinc-ribbon domain MCM_N PF14551.6 KII73347.1 - 0.042 14.4 0.1 0.056 14.0 0.1 1.3 1 0 0 1 1 1 0 MCM N-terminal domain AdoHcyase PF05221.17 KII73348.1 - 1.1e-28 100.2 0.0 1.2e-28 100.2 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KII73348.1 - 4.3e-16 59.4 0.0 6.3e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 KII73349.1 - 6.8e-44 150.2 0.2 1.2e-41 142.8 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KII73350.1 - 5.4e-28 98.1 0.5 6.4e-28 97.9 0.5 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 KII73350.1 - 3.5e-05 23.1 0.0 3.5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase THF_DHG_CYH_C PF02882.19 KII73350.1 - 0.0017 17.7 0.4 0.0026 17.1 0.4 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF2345 PF10106.9 KII73350.1 - 0.0057 16.5 0.1 0.012 15.5 0.1 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2345) Shikimate_DH PF01488.20 KII73350.1 - 0.14 12.2 0.1 0.22 11.6 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AdoHcyase_NAD PF00670.21 KII73351.1 - 1.9e-34 119.0 0.3 2.5e-34 118.7 0.3 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 KII73351.1 - 1e-06 28.2 0.0 1.1e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase THF_DHG_CYH_C PF02882.19 KII73351.1 - 0.12 11.7 0.5 0.18 11.1 0.5 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AdoHcyase PF05221.17 KII73352.1 - 1.1e-12 47.7 0.0 1.3e-12 47.5 0.0 1.3 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KII73352.1 - 1.8e-06 28.1 0.0 2.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF2753 PF10952.8 KII73352.1 - 0.018 15.1 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) GXWXG PF14231.6 KII73353.1 - 0.032 14.3 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 GXWXG protein AdoHcyase_NAD PF00670.21 KII73354.1 - 2.1e-54 184.0 3.4 2.9e-54 183.5 3.4 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 KII73354.1 - 3e-53 180.9 0.0 3.1e-41 141.5 0.0 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase 2-Hacid_dh_C PF02826.19 KII73354.1 - 9.9e-08 31.5 0.2 1.9e-07 30.6 0.2 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KII73354.1 - 5.1e-05 22.9 0.6 7.6e-05 22.3 0.6 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 KII73354.1 - 0.00049 20.3 0.3 0.0018 18.5 0.2 2.0 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 KII73354.1 - 0.0035 17.8 0.3 0.044 14.2 0.2 2.4 2 1 1 3 3 3 1 Putative NAD(P)-binding UDPG_MGDP_dh_C PF03720.15 KII73354.1 - 0.023 15.1 0.0 0.08 13.4 0.0 2.0 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Shikimate_DH PF01488.20 KII73354.1 - 0.031 14.3 0.2 0.051 13.6 0.2 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 KII73354.1 - 0.038 13.3 2.1 0.2 11.0 2.1 1.9 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF2753 PF10952.8 KII73354.1 - 0.06 13.5 0.4 0.12 12.5 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2753) E1_DerP2_DerF2 PF02221.15 KII73355.1 - 0.03 14.7 0.1 0.047 14.1 0.1 1.2 1 0 0 1 1 1 0 ML domain C6 PF01681.17 KII73355.1 - 0.13 12.8 0.1 0.2 12.2 0.1 1.5 1 1 0 1 1 1 0 C6 domain AdoHcyase_NAD PF00670.21 KII73356.1 - 1.6e-34 119.3 0.4 2.2e-34 118.9 0.4 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 KII73356.1 - 1.2e-27 96.9 0.0 1.2e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase 2-Hacid_dh_C PF02826.19 KII73356.1 - 0.11 11.8 0.0 0.26 10.6 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 KII73356.1 - 0.12 11.7 0.7 0.21 10.9 0.7 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AdoHcyase PF05221.17 KII73357.1 - 1.1e-53 182.3 0.1 1.1e-40 139.6 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KII73357.1 - 3.8e-06 27.1 0.0 9.3e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF2753 PF10952.8 KII73357.1 - 0.032 14.4 0.0 0.07 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) Siah-Interact_N PF09032.11 KII73361.1 - 0.02 15.2 0.2 0.03 14.6 0.2 1.2 1 0 0 1 1 1 0 Siah interacting protein, N terminal RTTN_N PF14726.6 KII73363.1 - 0.03 15.1 0.3 0.1 13.4 0.2 2.0 1 1 1 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning 7tm_1 PF00001.21 KII73365.1 - 4.6e-06 26.1 4.0 4.6e-06 26.1 4.0 1.8 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KII73369.1 - 5.9e-17 61.8 18.7 8.8e-17 61.3 18.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF948 PF06103.11 KII73369.1 - 0.042 14.1 0.4 0.14 12.5 0.4 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) 7TM_GPCR_Sru PF10322.9 KII73369.1 - 0.11 11.8 35.6 0.066 12.5 28.1 2.9 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru rve PF00665.26 KII73370.1 - 1.2e-05 25.5 0.0 0.00054 20.1 0.0 2.3 1 1 0 1 1 1 1 Integrase core domain zf-CCHC_3 PF13917.6 KII73370.1 - 3.6 7.6 6.2 0.93 9.5 1.3 2.2 1 1 1 2 2 2 0 Zinc knuckle DUF1077 PF06417.12 KII73371.1 - 0.15 12.1 0.1 0.32 11.0 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1077) RVP_2 PF08284.11 KII73373.1 - 0.018 14.8 0.1 0.026 14.3 0.1 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease Turandot PF07240.11 KII73373.1 - 0.065 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot MAGE_N PF12440.8 KII73373.1 - 0.58 10.9 9.3 0.97 10.2 9.1 1.6 1 1 0 1 1 1 0 Melanoma associated antigen family N terminal DUF573 PF04504.14 KII73374.1 - 0.095 13.4 0.1 0.15 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF573 TFIIA PF03153.13 KII73376.1 - 1.1e-30 108.0 2.6 5e-21 76.2 0.0 2.2 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit DsbC PF11412.8 KII73378.1 - 0.11 12.6 0.1 0.24 11.5 0.0 1.6 1 1 1 2 2 2 0 Disulphide bond corrector protein DsbC zf-CCHC_5 PF14787.6 KII73379.1 - 2.2e-05 24.0 0.6 3.7e-05 23.3 0.6 1.3 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.23 KII73379.1 - 0.0004 20.3 1.0 0.00061 19.7 1.0 1.3 1 0 0 1 1 1 1 Zinc knuckle Peptidase_M99 PF17033.5 KII73381.1 - 0.02 14.4 0.1 0.022 14.2 0.1 1.2 1 0 0 1 1 1 0 Carboxypeptidase controlling helical cell shape catalytic Sortilin_C PF15901.5 KII73382.1 - 1.2e-14 55.0 1.0 2.2e-14 54.2 1.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII73382.1 - 0.00022 20.8 1.7 0.14 12.2 0.1 4.2 4 0 0 4 4 4 2 BNR/Asp-box repeat DDE_Tnp_IS1595 PF12762.7 KII73387.1 - 6.8e-13 48.9 0.1 8e-13 48.7 0.1 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain NDUFA12 PF05071.16 KII73387.1 - 0.044 14.6 0.1 0.049 14.5 0.1 1.2 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 Hexokinase_2 PF03727.16 KII73389.1 - 2.7e-33 115.4 0.0 3.1e-33 115.2 0.0 1.0 1 0 0 1 1 1 1 Hexokinase Rtt106_N PF18215.1 KII73389.1 - 0.29 10.9 1.7 2.3 8.0 1.7 2.3 1 1 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain Hexokinase_1 PF00349.21 KII73390.1 - 1.6e-52 178.4 0.0 2e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 KII73390.1 - 1.4e-05 24.7 0.1 2e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Hexokinase MMtag PF10159.9 KII73393.1 - 7.4e-21 74.2 0.0 7.4e-21 74.2 0.0 1.9 2 0 0 2 2 2 1 Multiple myeloma tumor-associated NPR3 PF03666.13 KII73393.1 - 0.016 14.0 2.6 0.021 13.6 2.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3677 PF12432.8 KII73395.1 - 2.8e-06 27.5 0.1 1.7e-05 25.0 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3677) Phage_int_SAM_5 PF13102.6 KII73395.1 - 1.4 9.3 4.8 1 9.8 0.1 3.3 3 0 0 3 3 3 0 Phage integrase SAM-like domain WD40 PF00400.32 KII73397.1 - 3.2e-10 40.4 7.1 0.0036 18.1 0.0 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII73397.1 - 0.078 13.3 0.0 0.54 10.6 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RSS_P20 PF11757.8 KII73398.1 - 0.14 12.6 0.8 0.21 12.1 0.8 1.3 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain Phage_Treg PF04761.12 KII73402.1 - 0.063 13.4 0.0 0.094 12.8 0.0 1.2 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator zf-AN1 PF01428.16 KII73403.1 - 1.6e-07 31.4 15.6 1.6e-07 31.4 15.6 2.5 3 0 0 3 3 3 1 AN1-like Zinc finger zf-A20 PF01754.16 KII73403.1 - 1.5e-05 24.8 0.8 1.5e-05 24.8 0.8 2.7 2 0 0 2 2 2 1 A20-like zinc finger DUF5637 PF18687.1 KII73403.1 - 0.058 13.4 4.3 5.2 7.1 0.1 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5637) ApeC PF16977.5 KII73404.1 - 6.1e-65 219.0 6.6 8.2e-65 218.6 6.6 1.2 1 0 0 1 1 1 1 C-terminal domain of apextrin Laminin_G_3 PF13385.6 KII73405.1 - 4e-17 62.8 0.2 5.3e-17 62.4 0.2 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.17 KII73405.1 - 3.7e-06 26.8 0.0 6.2e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 Pentaxin family Cation_efflux PF01545.21 KII73406.1 - 2.7e-35 121.9 9.9 3.4e-35 121.6 9.9 1.1 1 0 0 1 1 1 1 Cation efflux family MerC PF03203.14 KII73406.1 - 0.047 14.1 3.4 0.63 10.5 0.1 2.9 2 1 1 3 3 3 0 MerC mercury resistance protein GHMP_kinases_N PF00288.26 KII73407.1 - 3.5e-17 62.4 0.2 6.4e-17 61.6 0.2 1.4 1 0 0 1 1 1 1 GHMP kinases N terminal domain Glyco_tranf_2_2 PF10111.9 KII73407.1 - 0.026 14.0 0.1 0.047 13.2 0.0 1.4 2 0 0 2 2 2 0 Glycosyltransferase like family 2 GalKase_gal_bdg PF10509.9 KII73408.1 - 0.0044 16.6 0.0 0.0068 15.9 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature RVT_1 PF00078.27 KII73409.1 - 0.00028 20.5 0.2 0.00042 19.9 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ATG101 PF07855.12 KII73410.1 - 0.09 12.8 0.1 0.16 12.0 0.0 1.3 1 1 0 1 1 1 0 Autophagy-related protein 101 DUF4231 PF14015.6 KII73414.1 - 0.031 14.7 3.6 3.4 8.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) PI3_PI4_kinase PF00454.27 KII73415.1 - 2e-33 116.3 0.1 1.1e-21 77.8 0.1 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KII73415.1 - 0.00053 19.4 0.3 0.048 13.1 0.0 2.3 1 1 1 2 2 2 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 KII73415.1 - 0.0079 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) DUF3196 PF11428.8 KII73415.1 - 0.016 14.8 0.2 1.4 8.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3196) DUF2838 PF10998.8 KII73418.1 - 0.98 9.7 4.5 0.3 11.3 0.8 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2838) ERCC4 PF02732.15 KII73419.1 - 3.1e-24 86.0 0.4 5.7e-24 85.1 0.4 1.5 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 KII73419.1 - 0.011 16.1 0.0 0.39 11.1 0.0 2.8 3 0 0 3 3 3 0 Helix-hairpin-helix domain Arrestin_C PF02752.22 KII73419.1 - 0.046 14.2 0.1 0.12 12.8 0.1 1.7 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain DS PF01916.17 KII73419.1 - 0.077 12.2 0.1 0.16 11.1 0.1 1.5 1 0 0 1 1 1 0 Deoxyhypusine synthase MLD PF11647.8 KII73420.1 - 0.076 13.3 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Membrane Localization Domain PAZ_siRNAbind PF12212.8 KII73421.1 - 0.39 10.5 2.9 1.2 9.0 0.1 2.1 1 1 1 2 2 2 0 PAZ domain HlyIII PF03006.20 KII73424.1 - 4.9e-56 189.9 31.6 6.1e-56 189.6 31.6 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.11 KII73424.1 - 0.37 10.9 5.6 6.1 7.0 5.6 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF962) Mem_trans PF03547.18 KII73425.1 - 0.15 10.4 0.3 0.24 9.8 0.1 1.4 2 0 0 2 2 2 0 Membrane transport protein DDE_3 PF13358.6 KII73426.1 - 3.3e-10 39.9 0.1 6.3e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII73427.1 - 5.8e-13 48.7 1.0 1e-12 47.9 0.7 1.6 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 KII73427.1 - 0.00067 19.2 0.1 0.0015 18.1 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 KII73427.1 - 0.017 14.9 0.1 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HTH_IclR PF09339.10 KII73427.1 - 0.034 13.9 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_psq PF05225.16 KII73427.1 - 0.082 12.7 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Zn_Tnp_IS1595 PF12760.7 KII73428.1 - 0.00023 21.0 3.1 0.00023 21.0 3.1 1.7 2 0 0 2 2 2 1 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.16 KII73428.1 - 0.0083 16.0 0.9 0.0083 16.0 0.9 3.0 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit zf-trcl PF13451.6 KII73428.1 - 0.032 14.1 2.9 0.032 14.1 2.9 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain FAM163 PF15069.6 KII73428.1 - 0.036 14.5 0.7 0.043 14.3 0.7 1.2 1 0 0 1 1 1 0 FAM163 family TFIIS_C PF01096.18 KII73428.1 - 0.18 11.7 14.3 0.24 11.3 0.3 3.4 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) Ribosomal_S27e PF01667.17 KII73428.1 - 3 7.6 7.1 27 4.6 3.5 3.0 2 1 0 2 2 2 0 Ribosomal protein S27 Rtt106 PF08512.12 KII73429.1 - 0.11 13.0 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Histone chaperone Rttp106-like POB3_N PF17292.2 KII73430.1 - 0.00017 21.9 0.1 0.00023 21.5 0.1 1.2 1 0 0 1 1 1 1 POB3-like N-terminal PH domain ERO1 PF04137.15 KII73432.1 - 6.7e-94 315.0 1.2 9.5e-94 314.5 1.2 1.2 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) IF4E PF01652.18 KII73433.1 - 6.1e-26 91.1 1.3 7.4e-26 90.8 1.3 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Sigma_1_2 PF03084.14 KII73433.1 - 0.034 13.4 0.0 0.042 13.1 0.0 1.0 1 0 0 1 1 1 0 Reoviral Sigma1/Sigma2 family DUF1548 PF07579.11 KII73436.1 - 0.0022 18.4 1.5 0.0054 17.1 1.5 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1548) DUF2018 PF09442.10 KII73436.1 - 0.31 12.1 3.3 0.75 10.8 3.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) LAGLIDADG_2 PF03161.13 KII73436.1 - 0.42 10.6 4.4 14 5.6 0.2 3.0 2 1 2 4 4 4 0 LAGLIDADG DNA endonuclease family MFS_1 PF07690.16 KII73439.1 - 1.6e-23 83.2 0.1 2e-23 82.9 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily EI24 PF07264.11 KII73439.1 - 0.26 11.5 9.2 0.39 10.9 9.2 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF4538 PF15061.6 KII73439.1 - 0.64 9.8 3.0 8.4 6.2 0.0 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4538) Ribosomal_L27_C PF18471.1 KII73442.1 - 0.019 14.4 4.1 0.038 13.4 4.1 1.4 1 0 0 1 1 1 0 Ribosomal L27 protein C-terminal domain Mus7 PF09462.10 KII73443.1 - 0.021 13.7 0.3 0.022 13.6 0.3 1.2 1 0 0 1 1 1 0 Mus7/MMS22 family Hrs_helical PF12210.8 KII73443.1 - 0.23 12.0 0.5 0.23 12.0 0.5 1.9 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate LacI PF00356.21 KII73444.1 - 0.027 14.3 0.6 0.37 10.6 0.1 2.5 2 1 1 3 3 3 0 Bacterial regulatory proteins, lacI family YidD PF01809.18 KII73447.1 - 0.15 11.9 0.0 0.33 10.9 0.0 1.6 2 0 0 2 2 2 0 Putative membrane protein insertion efficiency factor Herpes_US9 PF06072.11 KII73448.1 - 1.2 9.0 0.0 1.2 9.0 0.0 2.8 2 1 0 2 2 2 0 Alphaherpesvirus tegument protein US9 DUF1011 PF06237.12 KII73448.1 - 1.5 9.2 25.6 0.094 13.0 12.7 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1011) DDE_3 PF13358.6 KII73449.1 - 0.0003 20.6 0.0 0.0011 18.7 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease 5_nucleotid PF05761.14 KII73451.1 - 3.8e-84 283.2 2.1 4.3e-84 283.1 2.1 1.0 1 0 0 1 1 1 1 5' nucleotidase family PrmA PF06325.13 KII73452.1 - 8e-09 35.3 0.1 1.4e-08 34.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KII73452.1 - 3.6e-07 30.8 0.0 3.7e-06 27.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 KII73452.1 - 3.9e-07 29.3 0.0 6e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.12 KII73452.1 - 9.1e-06 26.2 0.1 0.00046 20.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain PRMT5_C PF17286.2 KII73452.1 - 1e-05 25.5 0.7 2.3e-05 24.3 0.7 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 KII73452.1 - 0.0002 21.3 0.0 0.00035 20.4 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_18 PF12847.7 KII73452.1 - 0.00034 20.6 0.1 0.014 15.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KII73452.1 - 0.00035 20.5 0.0 0.00062 19.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KII73452.1 - 0.00066 19.0 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 KII73452.1 - 0.0015 18.1 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain GidB PF02527.15 KII73452.1 - 0.0015 17.9 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_12 PF08242.12 KII73452.1 - 0.0048 17.6 0.5 0.17 12.7 0.0 3.0 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 KII73452.1 - 0.0073 16.1 0.2 0.072 12.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Rsm22 PF09243.10 KII73452.1 - 0.019 14.2 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Cons_hypoth95 PF03602.15 KII73452.1 - 0.061 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_16 PF10294.9 KII73452.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PCI PF01399.27 KII73454.1 - 1.4e-19 70.6 0.9 8.3e-19 68.1 0.2 2.4 2 0 0 2 2 2 1 PCI domain Rpn3_C PF08375.11 KII73454.1 - 0.00032 21.1 0.3 0.00075 19.9 0.3 1.7 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal HTH_47 PF16221.5 KII73454.1 - 0.056 13.0 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 winged helix-turn-helix DUF3371 PF11851.8 KII73454.1 - 0.15 13.2 0.1 0.34 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Desulfoferrod_N PF06397.12 KII73455.1 - 0.38 10.4 3.3 7.1 6.3 0.5 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain ALG11_N PF15924.5 KII73456.1 - 1e-57 195.6 0.4 1.5e-57 195.0 0.4 1.3 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 KII73456.1 - 3.6e-22 78.7 0.0 5.7e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KII73456.1 - 2e-11 44.5 0.0 3e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KII73456.1 - 0.00014 22.2 0.0 0.00029 21.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 ZnuA PF01297.17 KII73458.1 - 0.0061 16.0 1.6 0.011 15.2 1.6 1.5 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic PP_M1 PF03012.14 KII73458.1 - 3.5 7.1 8.2 4.6 6.7 8.2 1.1 1 0 0 1 1 1 0 Phosphoprotein Herpes_UL31 PF02718.14 KII73459.1 - 0.0026 16.8 0.0 0.0035 16.4 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus UL31-like protein WD40 PF00400.32 KII73460.1 - 0.038 14.9 0.1 0.17 12.8 0.0 2.0 2 0 0 2 2 2 0 WD domain, G-beta repeat Aa_trans PF01490.18 KII73462.1 - 2.9e-45 154.7 53.3 3.3e-45 154.5 53.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KII73462.1 - 7.5e-08 31.8 45.9 1.2e-07 31.1 45.9 1.3 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family DUF962 PF06127.11 KII73462.1 - 0.0022 18.0 1.0 0.12 12.5 0.0 3.7 1 1 1 2 2 2 1 Protein of unknown function (DUF962) DUF1676 PF07898.13 KII73462.1 - 3.6 7.6 11.9 0.15 12.1 0.4 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF1676) Ldl_recept_a PF00057.18 KII73463.1 - 5.5e-07 29.7 11.5 5.5e-07 29.7 11.5 2.8 2 1 1 3 3 3 1 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII73464.1 - 2.8e-15 57.1 1.5 4.6e-15 56.4 1.5 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII73464.1 - 6.8e-06 25.1 0.5 5.6e-05 22.1 0.1 2.0 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, DDE_Tnp_IS1595 PF12762.7 KII73466.1 - 5.3e-16 59.0 0.3 8.2e-16 58.4 0.2 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS240 PF13610.6 KII73466.1 - 0.014 15.6 0.0 0.019 15.2 0.0 1.1 1 0 0 1 1 1 0 DDE domain UPF0160 PF03690.13 KII73466.1 - 0.044 13.4 0.0 0.053 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) DUF3398 PF11878.8 KII73466.1 - 0.05 14.0 0.1 0.35 11.3 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3398) DDE_3 PF13358.6 KII73466.1 - 0.081 12.7 0.4 0.17 11.6 0.4 1.6 1 1 0 1 1 1 0 DDE superfamily endonuclease Phage_int_SAM_3 PF14659.6 KII73466.1 - 0.1 12.9 0.0 22 5.4 0.0 2.7 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain OSTMP1 PF09777.9 KII73466.1 - 0.11 11.9 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor Kelch_6 PF13964.6 KII73467.1 - 3.7e-23 81.0 22.1 2.7e-07 30.6 0.2 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII73467.1 - 5.3e-20 71.2 14.9 1.6e-05 25.1 0.3 6.8 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.6 KII73467.1 - 1.1e-15 57.3 16.2 0.00059 19.8 0.0 6.7 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73467.1 - 3.2e-14 52.2 21.8 0.00058 19.4 0.4 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 KII73467.1 - 2.6e-11 43.2 21.6 0.00017 21.5 0.3 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KII73467.1 - 3.8e-08 33.0 18.2 0.18 11.8 0.2 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII73468.1 - 9.7e-06 25.5 4.3 0.0084 16.1 0.2 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73468.1 - 1.9e-05 24.1 0.1 0.13 11.9 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 KII73468.1 - 0.0012 19.1 1.2 2.4 8.6 0.0 3.1 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII73468.1 - 0.12 12.7 1.4 28 5.1 0.1 3.1 2 1 1 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 KII73469.1 - 2.2e-13 49.9 1.7 6.3e-10 39.0 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 KII73469.1 - 4.8e-11 42.1 0.7 4.9e-09 35.6 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII73469.1 - 3.7e-09 36.6 1.0 1.3e-07 31.7 0.1 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 KII73469.1 - 3.8e-08 33.2 0.8 2.1e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 KII73469.1 - 3.1e-06 27.0 0.4 0.003 17.5 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 KII73469.1 - 0.00087 19.2 0.5 0.87 9.7 0.0 2.3 2 0 0 2 2 2 2 Kelch motif AIRS_C PF02769.22 KII73470.1 - 2.7e-24 86.1 0.0 3.3e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain Kelch_6 PF13964.6 KII73472.1 - 2.7e-08 33.8 10.0 0.00083 19.6 0.1 6.0 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 KII73472.1 - 0.00048 20.1 2.2 0.71 9.9 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII73472.1 - 0.00048 20.0 5.1 1.9 8.6 0.0 4.9 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 KII73472.1 - 0.0073 16.3 7.7 0.75 9.9 0.1 4.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_3 PF13415.6 KII73472.1 - 0.11 12.9 0.1 0.11 12.9 0.1 5.1 6 1 0 6 6 6 0 Galactose oxidase, central domain DUF1294 PF06961.13 KII73475.1 - 0.15 12.4 0.1 1.3 9.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1294) LAP1C PF05609.12 KII73476.1 - 0.36 9.9 14.2 0.45 9.6 14.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Rotamase_3 PF13616.6 KII73477.1 - 3.7e-20 72.6 0.3 1.5e-19 70.7 0.3 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 KII73477.1 - 1e-17 64.9 0.2 3.6e-17 63.1 0.2 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KII73477.1 - 3.4e-05 24.7 0.0 6.7e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain BRCT PF00533.26 KII73478.1 - 3.7e-19 68.9 0.1 1.6e-17 63.6 0.0 3.2 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 KII73478.1 - 1.2e-13 51.6 0.1 7.7e-13 49.0 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 KII73478.1 - 3e-07 30.4 0.6 3e-07 30.4 0.6 2.6 2 0 0 2 2 2 1 DNA polymerase III, delta subunit PTCB-BRCT PF12738.7 KII73478.1 - 3.3e-07 30.2 0.0 1.1e-06 28.5 0.0 2.0 2 0 0 2 2 1 1 twin BRCT domain RNA_helicase PF00910.22 KII73478.1 - 6.7e-06 26.5 0.2 2.6e-05 24.6 0.0 2.1 2 0 0 2 2 1 1 RNA helicase AAA_14 PF13173.6 KII73478.1 - 6.9e-06 26.1 0.0 2.3e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 KII73478.1 - 0.00011 22.2 2.3 0.00026 20.9 0.5 2.7 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 KII73478.1 - 0.00017 21.9 0.8 0.0025 18.1 0.0 2.8 3 0 0 3 3 2 1 AAA C-terminal domain AAA_16 PF13191.6 KII73478.1 - 0.00023 21.6 0.0 0.00082 19.8 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KII73478.1 - 0.00042 20.6 0.4 0.18 12.1 0.1 2.7 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KII73478.1 - 0.0013 18.0 0.0 0.0032 16.8 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_7 PF12775.7 KII73478.1 - 0.0017 17.9 0.0 0.0043 16.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region RuvB_N PF05496.12 KII73478.1 - 0.0019 18.0 0.0 0.0088 15.8 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain BRCT_2 PF16589.5 KII73478.1 - 0.0047 17.3 0.1 0.19 12.2 0.0 2.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain NTPase_1 PF03266.15 KII73478.1 - 0.0054 16.7 1.3 0.15 11.9 0.1 2.5 1 1 0 2 2 2 1 NTPase Sigma54_activ_2 PF14532.6 KII73478.1 - 0.0067 16.6 0.2 0.11 12.6 0.0 2.7 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_33 PF13671.6 KII73478.1 - 0.0092 16.1 0.0 0.025 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KII73478.1 - 0.0098 15.9 0.0 0.037 14.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 KII73478.1 - 0.012 16.0 0.9 0.041 14.3 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.6 KII73478.1 - 0.027 15.0 0.0 0.094 13.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 KII73478.1 - 0.062 13.1 0.3 1.4 8.7 0.0 2.5 1 1 1 2 2 2 0 DEAD/DEAH box helicase NACHT PF05729.12 KII73478.1 - 0.15 12.0 0.3 9.3 6.1 0.1 2.7 2 1 0 3 3 3 0 NACHT domain RFC1 PF08519.12 KII73479.1 - 2.1e-45 154.7 0.1 2.9e-45 154.3 0.1 1.2 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain Steroid_dh PF02544.16 KII73480.1 - 3.3e-23 82.3 4.4 3.3e-23 82.3 4.4 1.7 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 KII73480.1 - 0.0094 16.3 2.8 0.99 9.8 0.5 2.5 2 0 0 2 2 2 2 Phospholipid methyltransferase DUF1295 PF06966.12 KII73480.1 - 0.038 13.5 0.4 0.067 12.7 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) NT-C2 PF10358.9 KII73482.1 - 0.034 13.9 0.3 0.043 13.5 0.3 1.2 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins DUF2195 PF09961.9 KII73482.1 - 0.14 12.1 1.3 0.16 11.9 0.2 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2195) DUF826 PF05696.11 KII73486.1 - 0.076 13.1 0.2 2.4 8.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF826) PRESAN PF09687.10 KII73486.1 - 4.3 7.9 8.1 5.7 7.5 3.2 2.3 2 0 0 2 2 2 0 Plasmodium RESA N-terminal rve PF00665.26 KII73487.1 - 8e-25 87.4 0.0 1.5e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII73487.1 - 0.0017 18.6 0.4 0.0078 16.4 0.0 2.0 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.6 KII73487.1 - 0.0043 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII73487.1 - 0.044 13.9 3.5 0.051 13.7 0.8 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain MLVIN_C PF18697.1 KII73487.1 - 0.048 13.8 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain dUTPase PF00692.19 KII73492.1 - 0.076 12.7 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 dUTPase Kunitz_BPTI PF00014.23 KII73494.1 - 4.7e-05 23.6 9.4 0.073 13.3 10.3 2.3 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Cation_ATPase_C PF00689.21 KII73495.1 - 3e-39 134.6 1.2 4.1e-39 134.2 1.2 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KII73495.1 - 8.3e-18 65.4 0.1 6.4e-09 36.4 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KII73495.1 - 3.4e-06 27.0 0.9 0.00014 21.7 0.4 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KII73495.1 - 0.00018 22.0 0.1 0.00056 20.4 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KII73496.1 - 1e-49 168.5 1.4 8.5e-47 159.0 1.4 2.2 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 KII73496.1 - 7.3e-05 22.4 0.0 0.0011 18.6 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 KII73496.1 - 0.0019 18.3 0.0 0.0053 16.8 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) 7TMR-DISM_7TM PF07695.11 KII73496.1 - 0.0034 17.3 4.6 0.11 12.4 0.0 2.2 2 0 0 2 2 2 1 7TM diverse intracellular signalling Wzy_C PF04932.15 KII73496.1 - 0.018 14.7 0.1 3.4 7.3 0.1 2.3 2 0 0 2 2 2 0 O-Antigen ligase Peptidase_U4 PF03419.13 KII73496.1 - 0.019 14.3 1.9 0.033 13.5 0.0 2.0 2 0 0 2 2 2 0 Sporulation factor SpoIIGA Hydrolase PF00702.26 KII73496.1 - 0.035 14.4 0.0 0.072 13.4 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase CAAD PF14159.6 KII73496.1 - 0.058 13.2 5.4 0.16 11.8 5.4 1.7 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase hSH3 PF14603.6 KII73496.1 - 0.083 13.3 0.1 0.21 12.1 0.1 1.6 1 0 0 1 1 1 0 Helically-extended SH3 domain DUF2157 PF09925.9 KII73496.1 - 0.096 12.5 0.2 0.74 9.6 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DDE_3 PF13358.6 KII73497.1 - 1.6e-23 83.0 0.0 4.2e-23 81.7 0.0 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII73497.1 - 1.3e-05 24.8 0.7 0.00056 19.6 0.1 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.6 KII73497.1 - 0.00012 21.6 0.9 0.12 12.0 0.0 3.3 4 0 0 4 4 4 2 Winged helix-turn-helix DNA-binding HTH_Tnp_ISL3 PF13542.6 KII73497.1 - 0.0061 15.9 0.7 0.092 12.2 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_33 PF13592.6 KII73497.1 - 0.014 15.0 0.0 0.029 14.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Bot1p PF12298.8 KII73497.1 - 0.034 14.3 0.4 0.068 13.3 0.4 1.5 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein TrmB PF01978.19 KII73497.1 - 0.04 13.8 0.1 0.072 13.0 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sbi-IV PF11621.8 KII73497.1 - 0.13 12.6 0.1 0.37 11.2 0.0 1.8 2 0 0 2 2 2 0 C3 binding domain 4 of IgG-bind protein SBI Pro_isomerase PF00160.21 KII73503.1 - 2.2e-48 164.5 0.0 2.7e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Spy1 PF11357.8 KII73504.1 - 0.042 14.1 0.1 0.075 13.3 0.1 1.4 1 0 0 1 1 1 0 Cell cycle regulatory protein DDE_3 PF13358.6 KII73505.1 - 5.2e-05 23.0 0.8 5.8e-05 22.9 0.8 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease PilS PF08805.11 KII73506.1 - 0.00062 19.6 0.3 0.00095 19.0 0.3 1.3 1 0 0 1 1 1 1 PilS N terminal DUF2193 PF09959.9 KII73506.1 - 0.047 12.1 0.1 0.065 11.7 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) Pribosyltran PF00156.27 KII73507.1 - 3.9e-24 85.0 0.0 5.2e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KII73507.1 - 3.6e-05 23.3 0.0 5.5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase SAICAR_synt PF01259.18 KII73507.1 - 0.044 13.4 0.0 0.058 13.0 0.0 1.1 1 0 0 1 1 1 0 SAICAR synthetase PRT_C PF08372.10 KII73508.1 - 0.17 11.7 0.1 0.2 11.4 0.1 1.1 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal SYF2 PF08231.12 KII73509.1 - 3.8e-33 115.2 6.2 3.8e-33 115.2 6.2 2.2 1 1 1 2 2 2 1 SYF2 splicing factor SpoIIIAH PF12685.7 KII73509.1 - 0.013 15.3 6.5 0.022 14.6 6.5 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein CBP4 PF07960.11 KII73509.1 - 0.91 9.4 11.0 11 5.8 0.0 3.2 2 1 1 3 3 3 0 CBP4 DUF365 PF04033.12 KII73509.1 - 1.7 9.0 7.0 0.085 13.1 0.7 2.1 2 2 0 2 2 2 0 Domain of unknown function (DUF365) MoaC PF01967.21 KII73510.1 - 3.2e-47 160.0 0.1 3.9e-47 159.8 0.1 1.1 1 0 0 1 1 1 1 MoaC family UPF0182 PF03699.13 KII73510.1 - 0.014 13.6 0.0 0.016 13.4 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Reo_sigma1 PF01664.16 KII73510.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 Reovirus viral attachment protein sigma 1 Glycos_transf_2 PF00535.26 KII73512.1 - 0.00056 19.7 0.5 0.00088 19.1 0.2 1.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 4HPAD_g_N PF18671.1 KII73512.1 - 0.14 11.8 1.6 0.32 10.7 0.1 2.1 2 0 0 2 2 2 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal GATA PF00320.27 KII73513.1 - 3.3e-11 42.6 1.9 3.3e-11 42.6 1.9 2.9 3 0 0 3 3 3 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 KII73513.1 - 0.00013 21.4 5.1 0.028 14.0 1.8 2.8 2 1 0 2 2 2 2 TFIIB zinc-binding zf-TFIIB PF13453.6 KII73513.1 - 0.00014 21.1 0.2 0.00045 19.5 0.2 1.9 1 0 0 1 1 1 1 Transcription factor zinc-finger zinc_ribbon_9 PF14369.6 KII73513.1 - 0.00094 19.4 4.9 0.062 13.6 3.7 3.3 2 1 1 3 3 3 1 zinc-ribbon DUF1610 PF07754.11 KII73513.1 - 0.003 17.5 0.5 0.003 17.5 0.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1610) zf-FPG_IleRS PF06827.14 KII73513.1 - 0.029 14.2 0.6 0.082 12.8 0.6 1.9 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS A2L_zn_ribbon PF08792.10 KII73513.1 - 0.03 14.0 4.6 12 5.7 0.1 3.6 3 0 0 3 3 3 0 A2L zinc ribbon domain zf-RRN7 PF11781.8 KII73513.1 - 0.062 13.0 2.5 30 4.4 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Zn_Tnp_IS91 PF14319.6 KII73513.1 - 0.074 13.1 0.9 0.21 11.7 0.2 2.2 2 0 0 2 2 2 0 Transposase zinc-binding domain Zn-ribbon_8 PF09723.10 KII73513.1 - 0.076 13.1 1.1 1.5 9.0 0.5 2.7 2 1 0 2 2 2 0 Zinc ribbon domain DUF4428 PF14471.6 KII73513.1 - 0.09 12.7 4.3 13 5.8 0.0 3.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4428) zf_Rg PF17915.1 KII73513.1 - 0.11 12.0 0.7 1.1 8.7 0.1 2.3 2 0 0 2 2 2 0 Reverse gyrase zinc finger Prok-RING_1 PF14446.6 KII73513.1 - 0.13 12.2 1.0 0.45 10.5 0.1 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PhnA_Zn_Ribbon PF08274.12 KII73513.1 - 0.16 11.9 6.0 2.3 8.2 3.7 2.8 2 1 1 3 3 3 0 PhnA Zinc-Ribbon zf-IS66 PF13005.7 KII73513.1 - 0.26 11.7 1.3 25 5.4 0.1 3.3 3 0 0 3 3 3 0 zinc-finger binding domain of transposase IS66 DUF1272 PF06906.11 KII73513.1 - 0.3 11.2 2.2 1.1 9.3 2.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) DZR PF12773.7 KII73513.1 - 0.71 9.9 4.1 5.1 7.2 0.7 2.4 1 1 1 2 2 2 0 Double zinc ribbon NOB1_Zn_bind PF08772.11 KII73513.1 - 1.1 9.5 8.2 1.3 9.3 0.5 3.3 2 1 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like Nudix_N_2 PF14803.6 KII73513.1 - 1.4 8.9 4.1 11 6.1 0.0 3.4 3 0 0 3 3 3 0 Nudix N-terminal Zn_ribbon_SprT PF17283.2 KII73513.1 - 1.8 8.5 7.0 0.82 9.6 0.3 2.9 3 0 0 3 3 3 0 SprT-like zinc ribbon domain zinc_ribbon_10 PF10058.9 KII73513.1 - 2.6 7.9 6.6 0.27 11.0 1.7 1.9 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Prim_Zn_Ribbon PF08273.12 KII73513.1 - 6.5 7.1 8.1 8.8 6.7 0.5 3.2 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase Zn_Tnp_IS1595 PF12760.7 KII73513.1 - 6.6 6.8 9.1 64 3.6 3.1 3.3 1 1 2 3 3 3 0 Transposase zinc-ribbon domain TRAPPC9-Trs120 PF08626.11 KII73515.1 - 5.6e-11 40.6 3.6 8.6e-07 26.7 0.0 3.7 2 1 1 3 3 3 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.7 KII73515.1 - 0.0003 19.9 2.3 0.00059 18.9 2.3 1.4 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_12 PF13424.6 KII73515.1 - 0.051 13.9 0.5 0.22 11.8 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Kdo PF06293.14 KII73516.1 - 2.6e-06 26.9 0.0 3.6e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KII73516.1 - 2.9e-05 24.1 0.0 3.2e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 KII73516.1 - 8.6e-05 22.0 0.0 0.00014 21.3 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain EcKinase PF02958.20 KII73516.1 - 0.00053 19.4 0.0 0.00059 19.2 0.0 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 KII73516.1 - 0.0088 15.7 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 KII73516.1 - 0.02 14.2 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase CPSF_A PF03178.15 KII73517.1 - 5.5e-37 127.8 2.1 7.9e-35 120.7 1.6 2.6 2 0 0 2 2 2 2 CPSF A subunit region MMS1_N PF10433.9 KII73517.1 - 1.1e-21 77.0 7.1 1.9e-21 76.2 7.1 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term HSP20 PF00011.21 KII73518.1 - 2e-23 82.5 4.8 1.6e-15 57.1 0.2 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family HepII_C PF18675.1 KII73518.1 - 0.00043 20.3 0.1 0.011 15.8 0.1 2.3 1 1 1 2 2 2 2 Heparinase II C-terminal domain DBB PF14545.6 KII73518.1 - 0.048 13.6 0.1 0.096 12.6 0.1 1.4 1 0 0 1 1 1 0 Dof, BCAP, and BANK (DBB) motif, MLVIN_C PF18697.1 KII73519.1 - 0.00015 21.8 0.0 0.00023 21.2 0.0 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DUF3165 PF11364.8 KII73523.1 - 0.038 14.3 1.5 0.17 12.2 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3165) Lamp PF01299.17 KII73523.1 - 0.05 13.4 1.4 0.1 12.5 1.1 1.6 1 1 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Arabinose_trans PF04602.12 KII73524.1 - 0.04 12.8 0.0 0.048 12.5 0.0 1.1 1 0 0 1 1 1 0 Mycobacterial cell wall arabinan synthesis protein SpoIIIAH PF12685.7 KII73525.1 - 0.0017 18.3 5.0 0.0023 17.8 5.0 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein Presenilin PF01080.17 KII73525.1 - 0.56 8.9 7.2 0.56 8.9 7.2 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 KII73525.1 - 1.2 8.3 3.0 1.1 8.4 3.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Pannexin_like PF12534.8 KII73525.1 - 1.8 7.6 5.8 2 7.5 5.8 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 RR_TM4-6 PF06459.12 KII73525.1 - 9.1 6.0 18.9 13 5.5 18.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TRAP_alpha PF03896.16 KII73527.1 - 2.7e-29 102.3 0.3 3.6e-29 101.9 0.3 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Pox_A14 PF05767.12 KII73527.1 - 0.022 14.9 0.8 0.035 14.2 0.1 1.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF3139 PF11337.8 KII73527.1 - 1.3 9.7 7.8 5.3 7.8 0.7 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF3139) CSD PF00313.22 KII73529.1 - 2.8e-08 33.5 0.1 4.8e-08 32.7 0.1 1.4 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain Prot_ATP_ID_OB PF16450.5 KII73529.1 - 0.049 13.6 0.0 0.067 13.2 0.0 1.3 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain HTH_Tnp_Tc5 PF03221.16 KII73530.1 - 1e-07 31.9 0.2 2.1e-07 30.9 0.2 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain ENTH PF01417.20 KII73531.1 - 1.4e-29 102.6 0.1 2.2e-29 102.1 0.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 KII73531.1 - 8.5e-08 31.5 0.1 1.2e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 ANTH domain UIM PF02809.20 KII73531.1 - 0.21 11.6 4.8 0.32 11.0 1.7 2.5 2 0 0 2 2 2 0 Ubiquitin interaction motif CM_1 PF07736.11 KII73533.1 - 0.051 14.0 0.1 0.13 12.7 0.1 1.7 1 0 0 1 1 1 0 Chorismate mutase type I EIF_2_alpha PF07541.12 KII73533.1 - 0.16 12.1 1.6 0.28 11.3 0.4 1.9 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit Oxidored_q6 PF01058.22 KII73535.1 - 6.8e-22 77.7 0.1 1.1e-21 77.0 0.1 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Galactosyl_T PF01762.21 KII73538.1 - 4.7e-08 33.1 0.1 5.1e-08 33.0 0.1 1.0 1 0 0 1 1 1 1 Galactosyltransferase Ribosomal_L18p PF00861.22 KII73539.1 - 0.00011 22.5 0.0 0.00017 21.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast DUF1981 PF09324.10 KII73541.1 - 0.047 13.5 0.1 0.084 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) DDE_Tnp_IS1595 PF12762.7 KII73542.1 - 7.1e-09 35.8 0.0 1.8e-08 34.5 0.0 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII73542.1 - 0.076 12.8 2.1 0.23 11.2 2.1 2.1 1 1 0 1 1 1 0 DDE superfamily endonuclease YiaAB PF05360.14 KII73543.1 - 0.2 11.9 2.3 0.48 10.7 2.3 1.7 1 0 0 1 1 1 0 yiaA/B two helix domain DUF2427 PF10348.9 KII73543.1 - 2.6 7.9 8.4 0.52 10.1 0.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) DUF2457 PF10446.9 KII73543.1 - 2.6 7.1 12.7 3.4 6.7 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) ECF_trnsprt PF12822.7 KII73543.1 - 4.4 7.4 9.6 1.7 8.7 6.8 1.6 1 1 1 2 2 2 0 ECF transporter, substrate-specific component HTH_Tnp_Tc5 PF03221.16 KII73547.1 - 3e-14 52.8 0.3 5.3e-14 52.0 0.3 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 KII73547.1 - 0.00016 21.2 0.1 0.00037 20.0 0.1 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_3 PF01381.22 KII73547.1 - 0.012 15.6 0.7 0.061 13.4 0.2 2.1 2 0 0 2 2 2 0 Helix-turn-helix ParE_toxin PF05016.15 KII73547.1 - 0.017 15.7 0.0 0.034 14.8 0.0 1.4 1 0 0 1 1 1 0 ParE toxin of type II toxin-antitoxin system, parDE HTH_IclR PF09339.10 KII73547.1 - 0.023 14.5 0.1 0.062 13.1 0.0 1.7 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_23 PF13384.6 KII73547.1 - 0.24 11.2 2.0 0.82 9.5 0.0 2.7 3 0 0 3 3 3 0 Homeodomain-like domain Prenyltransf PF01255.19 KII73548.1 - 0.041 13.4 0.0 0.043 13.3 0.0 1.1 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase HTH_IclR PF09339.10 KII73548.1 - 0.1 12.4 0.4 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain BLM10_N PF16547.5 KII73550.1 - 0.05 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, N-terminal GldM_C PF12080.8 KII73551.1 - 0.028 14.7 0.0 0.049 13.9 0.0 1.4 1 0 0 1 1 1 0 GldM C-terminal domain Clathrin_bdg PF15045.6 KII73552.1 - 0.16 11.9 0.2 0.3 11.1 0.2 1.6 1 1 0 1 1 1 0 Clathrin-binding box of Aftiphilin, vesicle trafficking CBS PF00571.28 KII73553.1 - 4.8e-10 39.7 1.1 0.00092 19.6 0.0 2.6 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 KII73553.1 - 0.083 13.0 0.0 0.27 11.3 0.0 1.8 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain DDE_3 PF13358.6 KII73555.1 - 0.0015 18.3 0.1 0.0019 18.0 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Ribosomal_S17 PF00366.20 KII73559.1 - 0.00067 19.7 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 DUF445 PF04286.12 KII73562.1 - 0.034 14.0 6.0 0.039 13.8 6.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) YpjP PF14005.6 KII73562.1 - 0.92 9.6 13.4 0.89 9.6 2.4 2.8 1 1 1 2 2 2 0 YpjP-like protein SNAP PF14938.6 KII73563.1 - 5.6e-09 35.8 0.1 7.9e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 KII73563.1 - 0.013 15.6 5.2 0.13 12.5 0.4 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII73563.1 - 0.013 15.3 0.7 0.88 9.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 KII73563.1 - 0.78 9.8 4.3 1.3 9.1 0.4 2.9 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 KII73563.1 - 4.4 7.1 7.0 1.7 8.4 0.2 3.3 4 0 0 4 4 4 0 TPR repeat NSF PF02071.20 KII73563.1 - 6.8 7.9 8.6 24 6.3 1.4 3.8 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat GATA PF00320.27 KII73565.1 - 2.3e-11 43.1 1.1 4.4e-11 42.2 1.1 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 KII73565.1 - 0.0067 15.9 1.0 0.0067 15.9 1.0 1.9 2 0 0 2 2 2 1 TFIIB zinc-binding Ion_trans PF00520.31 KII73566.1 - 3.9e-05 23.0 0.4 4.7e-05 22.7 0.4 1.1 1 0 0 1 1 1 1 Ion transport protein DUF1899 PF08953.11 KII73571.1 - 1.7e-17 63.0 0.1 5.7e-17 61.3 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 KII73571.1 - 8.6e-17 60.8 0.1 1.5e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 KII73571.1 - 0.00021 22.0 0.1 0.23 12.4 0.1 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII73571.1 - 0.00084 19.6 0.0 0.18 12.1 0.1 2.8 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 KII73571.1 - 0.027 14.0 0.4 0.055 13.0 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4221) PQQ PF01011.21 KII73571.1 - 0.13 12.3 0.0 2.2 8.3 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat BCS1_N PF08740.11 KII73573.1 - 0.069 13.1 0.1 0.069 13.1 0.1 1.1 1 0 0 1 1 1 0 BCS1 N terminal FmiP_Thoc5 PF09766.9 KII73574.1 - 1.1e-15 57.8 2.0 2.1e-13 50.3 0.5 3.0 2 1 0 2 2 2 2 Fms-interacting protein/Thoc5 XhlA PF10779.9 KII73574.1 - 0.057 13.6 0.6 0.15 12.3 0.1 1.9 2 0 0 2 2 2 0 Haemolysin XhlA PI3K_P85_iSH2 PF16454.5 KII73574.1 - 0.06 12.9 0.4 0.11 12.1 0.4 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SCAMP PF04144.13 KII73576.1 - 0.0019 18.6 16.2 0.0025 18.1 16.2 1.2 1 0 0 1 1 1 1 SCAMP family Mito_morph_reg PF14972.6 KII73577.1 - 2.6e-14 53.2 0.1 3.3e-14 52.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial morphogenesis regulator DUF3754 PF12576.8 KII73577.1 - 0.058 13.3 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) HTH_Tnp_Tc3_2 PF01498.18 KII73578.1 - 0.0083 16.4 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Transposase Transcrip_reg PF01709.20 KII73579.1 - 0.079 12.4 0.9 0.091 12.2 0.1 1.4 2 0 0 2 2 2 0 Transcriptional regulator DDE_3 PF13358.6 KII73580.1 - 1.7e-15 57.0 0.1 2.2e-15 56.7 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Kunitz_BPTI PF00014.23 KII73585.1 - 4.9e-07 29.9 7.2 4.9e-07 29.9 7.2 2.4 3 0 0 3 3 3 1 Kunitz/Bovine pancreatic trypsin inhibitor domain c-SKI_SMAD_bind PF08782.10 KII73585.1 - 0.005 17.0 1.6 0.0097 16.1 1.6 1.5 1 0 0 1 1 1 1 c-SKI Smad4 binding domain Kunitz_BPTI PF00014.23 KII73587.1 - 0.00012 22.3 8.6 0.00012 22.3 8.6 2.6 2 1 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Kunitz_BPTI PF00014.23 KII73588.1 - 0.00023 21.3 16.5 0.00069 19.8 7.9 2.5 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Kunitz_BPTI PF00014.23 KII73589.1 - 0.32 11.3 15.7 0.99 9.7 6.1 2.5 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF4005 PF13178.6 KII73590.1 - 0.059 14.0 1.9 0.11 13.1 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4005) Baculo_LEF-2 PF03041.14 KII73591.1 - 0.032 13.9 0.1 0.038 13.6 0.1 1.1 1 0 0 1 1 1 0 lef-2 Kunitz_BPTI PF00014.23 KII73591.1 - 0.061 13.6 3.7 2.9 8.2 0.1 2.4 2 0 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF1472 PF07339.12 KII73592.1 - 0.11 13.0 0.3 0.17 12.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1472) Filamin PF00630.19 KII73596.1 - 0.085 13.7 0.0 0.099 13.5 0.0 1.3 1 1 0 1 1 1 0 Filamin/ABP280 repeat PRELI PF04707.14 KII73598.1 - 1e-30 106.6 0.3 1.9e-30 105.7 0.3 1.5 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.20 KII73598.1 - 1e-21 77.3 0.1 5.4e-21 75.0 0.1 2.1 1 1 0 1 1 1 1 CRAL/TRIO domain ATP-synt PF00231.19 KII73598.1 - 0.065 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 ATP synthase Methyltransf_15 PF09445.10 KII73600.1 - 1e-18 67.5 0.0 1.1e-18 67.4 0.0 1.0 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase DUF4358 PF14270.6 KII73600.1 - 0.018 15.3 0.1 0.024 14.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4358) Hexapep PF00132.24 KII73601.1 - 1.9e-09 36.9 11.5 5.4e-06 25.9 1.0 4.4 2 2 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 KII73601.1 - 0.014 14.4 0.6 0.13 11.1 0.3 2.2 1 1 2 3 3 3 0 L-fucokinase DUF4954 PF16314.5 KII73601.1 - 0.014 13.6 1.1 0.023 12.8 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 KII73601.1 - 0.49 10.2 12.8 0.052 13.3 3.8 3.4 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase PK PF00224.21 KII73602.1 - 4.4e-83 279.1 2.7 5.5e-83 278.7 2.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KII73602.1 - 1.8e-29 102.3 0.3 5.1e-29 100.9 0.2 1.9 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain DUF1075 PF06388.11 KII73606.1 - 0.016 15.3 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) DUF3149 PF11346.8 KII73606.1 - 0.84 9.3 5.4 1.6 8.4 5.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) TraQ PF09679.10 KII73607.1 - 0.059 13.3 0.1 0.095 12.6 0.1 1.2 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) Ldl_recept_a PF00057.18 KII73612.1 - 1.5e-21 76.3 48.2 3.3e-12 46.4 17.4 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A SNAP PF14938.6 KII73613.1 - 1.1e-07 31.6 0.1 1.3e-07 31.3 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 KII73613.1 - 0.0076 16.1 0.0 0.055 13.4 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KII73613.1 - 0.05 13.9 0.1 0.41 11.0 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KII73613.1 - 5.9 7.3 7.4 3 8.2 0.8 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Kelch_6 PF13964.6 KII73614.1 - 9.6e-24 82.8 9.1 6.5e-05 23.1 0.0 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KII73614.1 - 4.4e-21 74.6 9.0 1.4e-05 25.0 0.0 4.8 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73614.1 - 2.2e-20 71.9 6.2 4.4e-06 26.2 0.2 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KII73614.1 - 8.6e-19 67.4 1.4 0.00066 19.9 0.1 5.0 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KII73614.1 - 5.8e-09 35.6 10.8 0.019 15.0 0.1 5.4 5 1 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 KII73614.1 - 0.00027 20.8 6.7 1.3 9.1 0.0 5.0 5 0 0 5 5 5 2 Kelch motif DUF3839 PF12943.7 KII73617.1 - 0.0023 17.4 0.1 0.0025 17.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3839) rve PF00665.26 KII73618.1 - 0.00084 19.5 0.0 0.0011 19.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII73618.1 - 0.0045 16.7 0.1 0.013 15.2 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII73619.1 - 5.8e-12 45.5 0.0 8.3e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Integrase zinc binding domain Ras PF00071.22 KII73621.1 - 1.4e-59 200.3 0.6 1.7e-59 200.0 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII73621.1 - 4.4e-34 117.3 0.1 8.2e-34 116.4 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII73621.1 - 9.8e-16 57.7 0.1 1.3e-15 57.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KII73621.1 - 4.8e-06 26.6 0.1 9.8e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KII73621.1 - 3.5e-05 23.3 0.2 5e-05 22.8 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KII73621.1 - 4.7e-05 23.4 1.3 0.017 15.0 0.2 2.3 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KII73621.1 - 7.1e-05 22.4 0.1 0.00025 20.7 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KII73621.1 - 0.00048 19.6 0.0 0.0017 17.9 0.0 1.6 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 KII73621.1 - 0.0017 18.1 0.8 0.0095 15.7 0.7 2.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KII73621.1 - 0.0017 18.6 0.1 0.012 15.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KII73621.1 - 0.0052 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TniB PF05621.11 KII73621.1 - 0.0057 16.1 0.0 0.016 14.6 0.0 1.7 2 0 0 2 2 2 1 Bacterial TniB protein AAA_16 PF13191.6 KII73621.1 - 0.0076 16.6 0.0 0.011 16.2 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KII73621.1 - 0.018 15.0 0.0 0.03 14.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 KII73621.1 - 0.05 14.1 0.2 0.073 13.6 0.1 1.6 1 1 0 1 1 1 0 ABC transporter MCM PF00493.23 KII73621.1 - 0.06 12.4 0.2 0.14 11.2 0.0 1.7 2 0 0 2 2 2 0 MCM P-loop domain PduV-EutP PF10662.9 KII73621.1 - 0.09 12.5 0.0 0.24 11.2 0.0 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 KII73621.1 - 0.096 13.1 0.2 0.55 10.7 0.0 2.3 1 1 1 2 2 2 0 RNA helicase NACHT PF05729.12 KII73621.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain FeoB_N PF02421.18 KII73621.1 - 0.13 11.8 0.2 3.7 7.1 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B Dscam_C PF12355.8 KII73622.1 - 0.0067 17.4 0.2 0.0086 17.0 0.2 1.2 1 0 0 1 1 1 1 Down syndrome cell adhesion molecule C terminal Pheromone PF08015.11 KII73622.1 - 2.8 9.1 7.3 5.8 8.0 7.3 1.5 1 0 0 1 1 1 0 Fungal mating-type pheromone Serpin PF00079.20 KII73625.1 - 1.6e-13 50.7 0.0 2.1e-13 50.4 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73626.1 - 1.6e-10 40.8 0.0 2e-10 40.6 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73627.1 - 7.2e-17 61.7 1.4 8.4e-17 61.5 1.4 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73628.1 - 6.4e-07 29.0 0.0 6.7e-07 28.9 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73629.1 - 1.6e-15 57.3 0.3 2e-15 57.0 0.3 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73630.1 - 4e-14 52.7 5.7 4.9e-14 52.4 5.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DOT1 PF08123.13 KII73630.1 - 0.034 13.7 1.4 0.043 13.3 1.4 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Serpin PF00079.20 KII73631.1 - 1.2e-12 47.9 2.9 1.4e-12 47.6 2.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73632.1 - 2.2e-36 125.9 6.1 2.5e-36 125.8 6.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73633.1 - 2.7e-38 132.3 5.1 3.1e-38 132.1 5.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73634.1 - 7.2e-08 32.1 2.0 8.6e-08 31.9 2.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) HTH_Tnp_Tc3_2 PF01498.18 KII73635.1 - 0.014 15.6 0.1 0.048 13.9 0.1 1.8 2 0 0 2 2 2 0 Transposase HTH_32 PF13565.6 KII73635.1 - 0.059 14.0 0.0 0.083 13.5 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain Serpin PF00079.20 KII73637.1 - 6.1e-05 22.5 1.2 6.7e-05 22.4 1.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) uDENN PF03456.18 KII73639.1 - 3.5e-10 40.5 0.4 3.5e-10 40.5 0.4 1.9 2 0 0 2 2 2 1 uDENN domain DUF2464 PF10240.9 KII73639.1 - 0.04 13.5 0.7 0.067 12.8 0.1 1.6 2 0 0 2 2 2 0 Multivesicular body subunit 12 Pkinase_Tyr PF07714.17 KII73640.1 - 4.8e-09 35.9 0.2 1.2e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 KII73640.1 - 5.9e-07 29.1 1.5 9.9e-07 28.4 0.0 2.3 3 0 0 3 3 3 1 Protein kinase domain OSR1_C PF12202.8 KII73640.1 - 3.2e-06 27.3 2.3 0.058 13.6 0.0 2.9 3 0 0 3 3 3 2 Oxidative-stress-responsive kinase 1 C-terminal domain COQ7 PF03232.13 KII73640.1 - 0.1 12.4 0.6 0.33 10.7 0.6 1.9 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 FCH PF00611.23 KII73641.1 - 0.00021 21.5 0.4 0.00021 21.5 0.4 2.5 2 1 1 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain Thioredoxin_11 PF18078.1 KII73641.1 - 0.052 13.7 0.4 0.27 11.3 0.4 2.0 2 0 0 2 2 2 0 Thioredoxin-like SNTX domain Spore_III_AB PF09548.10 KII73641.1 - 0.08 13.1 0.6 0.27 11.3 0.6 1.9 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DBD_HTH PF18430.1 KII73641.1 - 0.095 12.5 1.9 0.21 11.4 0.3 2.2 2 0 0 2 2 2 0 Putative DNA-binding domain YcbB PF08664.10 KII73641.1 - 0.12 12.4 3.0 0.16 12.0 0.4 2.2 2 1 0 2 2 2 0 YcbB domain HEPN_Toprim_N PF18871.1 KII73641.1 - 0.22 11.4 1.6 2.4 8.0 0.2 2.1 2 0 0 2 2 2 0 HEPN/Toprim N-terminal domain 1 PAC4 PF16093.5 KII73643.1 - 0.021 15.0 0.0 0.042 14.0 0.0 1.6 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 CaATP_NAI PF12515.8 KII73644.1 - 0.038 13.6 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Serpin PF00079.20 KII73645.1 - 3.5e-26 92.4 1.6 3.9e-26 92.2 1.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73646.1 - 0.0047 16.3 0.0 0.005 16.2 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4049 PF13258.6 KII73646.1 - 0.032 13.3 0.0 0.034 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4049) GT-D PF08759.11 KII73651.1 - 0.041 13.6 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase GT-D fold POTRA PF07244.15 KII73654.1 - 0.0046 17.5 0.8 0.01 16.4 0.8 1.5 1 0 0 1 1 1 1 Surface antigen variable number repeat Gemini_AL1_M PF08283.11 KII73656.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Geminivirus rep protein central domain rve PF00665.26 KII73658.1 - 7.5e-07 29.4 0.0 1.3e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DUF5003 PF16394.5 KII73658.1 - 0.064 12.4 0.1 0.074 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5003) adh_short PF00106.25 KII73660.1 - 2.8e-21 75.9 0.0 1.5e-20 73.5 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KII73660.1 - 1.6e-10 41.0 0.0 1.3e-09 38.0 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KII73660.1 - 6.9e-07 29.4 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KII73660.1 - 4.9e-05 22.9 0.0 7.5e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KII73660.1 - 0.001 18.6 0.0 0.0015 18.0 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 KII73660.1 - 0.0066 16.4 0.0 0.14 12.0 0.0 2.2 2 0 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 KII73660.1 - 0.094 11.7 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KII73660.1 - 0.12 11.4 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DDE_3 PF13358.6 KII73661.1 - 3.3e-19 69.1 0.0 6.3e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_7 PF02796.15 KII73661.1 - 0.13 12.4 0.8 0.25 11.4 0.1 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Transposase_1 PF01359.18 KII73661.1 - 0.13 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Transposase (partial DDE domain) CCDC117 PF15810.5 KII73662.1 - 0.01 16.2 0.1 0.99 9.7 0.0 2.1 1 1 1 2 2 2 2 Coiled-coil domain-containing protein 117 RNA_pol_Rpc34 PF05158.12 KII73662.1 - 0.04 13.3 0.3 0.056 12.8 0.3 1.2 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit DUF659 PF04937.15 KII73665.1 - 0.13 12.1 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) CUE PF02845.16 KII73666.1 - 1.2e-06 28.1 0.0 0.1 12.3 0.0 3.0 4 0 0 4 4 4 2 CUE domain OstA_2 PF13100.6 KII73666.1 - 0.00051 19.7 0.6 0.91 9.1 0.1 2.2 2 0 0 2 2 2 2 OstA-like protein E2F_CC-MB PF16421.5 KII73666.1 - 0.0038 17.5 1.0 2.2 8.7 0.0 2.8 3 1 0 3 3 3 2 E2F transcription factor CC-MB domain Nuclease_act PF08133.11 KII73666.1 - 0.0059 16.7 0.0 9.7 6.6 0.0 3.1 2 0 0 2 2 2 2 Anticodon nuclease activator family RNA_pol_Rbc25 PF08292.12 KII73666.1 - 0.045 14.0 0.0 4.1 7.7 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Sec34 PF04136.15 KII73666.1 - 0.049 13.5 0.4 8.6 6.2 0.1 2.4 2 1 0 2 2 2 0 Sec34-like family IreB PF06135.12 KII73666.1 - 0.074 13.3 0.0 20 5.5 0.0 2.3 2 0 0 2 2 2 0 IreB regulatory phosphoprotein Tudor-knot PF11717.8 KII73666.1 - 0.24 11.3 3.5 9.6 6.2 0.3 2.3 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain RTT107_BRCT_6 PF16771.5 KII73666.1 - 0.26 11.4 4.7 7.9 6.7 0.7 2.7 3 1 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain RT_RNaseH_2 PF17919.1 KII73667.1 - 3.7e-07 30.1 0.0 5.9e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Sortilin-Vps10 PF15902.5 KII73669.1 - 4.3e-08 32.4 0.2 5.9e-08 31.9 0.2 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII73669.1 - 0.0013 18.4 2.1 2.9 8.3 0.0 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat VKOR PF07884.14 KII73671.1 - 0.01 16.1 0.5 0.014 15.6 0.5 1.2 1 0 0 1 1 1 1 Vitamin K epoxide reductase family RT_RNaseH PF17917.1 KII73675.1 - 2.3e-18 66.4 0.0 4.6e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII73675.1 - 1.3e-13 50.8 0.4 8.8e-13 48.2 0.1 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase DDE_Tnp_IS1595 PF12762.7 KII73676.1 - 6.2e-06 26.3 0.0 6.6e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain EzrA PF06160.12 KII73677.1 - 0.033 12.4 1.4 0.029 12.6 0.5 1.4 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Acatn PF13000.7 KII73678.1 - 1.8e-13 49.9 6.2 7.8e-13 47.8 6.2 1.8 1 1 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Cnd3 PF12719.7 KII73679.1 - 0.00049 19.4 0.0 0.00054 19.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain DUF3819 PF12842.7 KII73680.1 - 0.042 13.8 0.0 0.051 13.5 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3819) MMtag PF10159.9 KII73681.1 - 7.3e-24 83.9 0.9 7.3e-24 83.9 0.9 2.1 2 0 0 2 2 2 1 Multiple myeloma tumor-associated Beach PF02138.18 KII73683.1 - 1.6e-113 378.7 0.3 1.6e-113 378.7 0.3 2.4 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 KII73683.1 - 1.1e-07 31.8 0.1 4.3e-07 29.9 0.1 2.0 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 KII73683.1 - 0.00068 20.4 0.3 0.0041 17.9 0.0 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Laminin_G_3 PF13385.6 KII73683.1 - 0.00075 19.7 0.0 0.0018 18.5 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily RPAP3_C PF13877.6 KII73683.1 - 0.086 13.4 0.2 1.6 9.3 0.0 3.5 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 DUF2746 PF10874.8 KII73685.1 - 0.11 12.9 0.4 0.21 12.0 0.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2746) AlphaC_C PF17480.2 KII73685.1 - 1.2 9.2 6.0 1.2 9.2 0.8 2.4 2 0 0 2 2 2 0 AlphaC C-terminal DUF3641 PF12345.8 KII73686.1 - 0.056 13.5 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3641) DUF2746 PF10874.8 KII73687.1 - 0.11 12.9 0.4 0.21 12.0 0.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2746) AlphaC_C PF17480.2 KII73687.1 - 1.2 9.2 6.0 1.2 9.2 0.8 2.4 2 0 0 2 2 2 0 AlphaC C-terminal Serpin PF00079.20 KII73690.1 - 3.5e-46 158.2 0.9 4.1e-46 158.0 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_3 PF13358.6 KII73691.1 - 1.2e-28 99.7 0.0 1.9e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII73691.1 - 0.013 15.1 0.0 0.029 14.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII73691.1 - 0.017 15.3 0.3 0.05 13.9 0.1 1.9 2 0 0 2 2 2 0 Transposase OST_P2 PF18235.1 KII73693.1 - 0.097 12.6 0.0 0.2 11.6 0.0 1.5 1 1 0 1 1 1 0 Oligosaccharyltransferase Peripheral 2 domain RWD PF05773.22 KII73695.1 - 8.7e-08 32.5 0.5 1.6e-07 31.6 0.5 1.5 1 0 0 1 1 1 1 RWD domain Gp_dh_C PF02800.20 KII73697.1 - 3.7e-56 189.1 0.0 5.1e-56 188.6 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KII73697.1 - 8.6e-30 103.1 0.1 1.8e-29 102.0 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ResB PF05140.14 KII73697.1 - 0.076 11.7 0.0 0.088 11.5 0.0 1.1 1 0 0 1 1 1 0 ResB-like family Peptidase_M1 PF01433.20 KII73698.1 - 5.6e-78 261.4 0.2 1.1e-77 260.5 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KII73698.1 - 2.2e-48 165.4 0.0 3.2e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain zf-H2C2_2 PF13465.6 KII73700.1 - 1.3e-11 44.3 9.4 2.4e-08 34.0 0.8 4.5 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 KII73700.1 - 3.9e-11 42.8 27.3 0.00012 22.4 1.5 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII73700.1 - 8.9e-07 29.2 20.1 0.016 16.0 1.3 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KII73700.1 - 0.028 14.7 7.2 0.11 12.8 6.7 2.1 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 KII73700.1 - 0.041 14.2 3.7 3.7 8.0 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 KII73700.1 - 0.67 10.1 3.2 9.4 6.3 0.6 2.2 1 1 0 2 2 2 0 Aberrant zinc-finger zf-met PF12874.7 KII73700.1 - 0.71 10.3 5.0 8 7.0 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type IBR PF01485.21 KII73700.1 - 1.1 9.5 6.0 5.1 7.4 6.0 2.0 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain FOXP-CC PF16159.5 KII73700.1 - 6.8 7.4 6.9 4 8.1 1.4 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain GCS PF03074.16 KII73702.1 - 2.1e-69 234.7 3.1 3.8e-67 227.2 3.1 2.6 1 1 0 1 1 1 1 Glutamate-cysteine ligase DUF4957 PF16318.5 KII73704.1 - 0.012 15.6 0.3 0.017 15.1 0.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4957) DUF5340 PF17275.2 KII73704.1 - 0.045 13.9 0.0 0.085 13.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5340) DUF247 PF03140.15 KII73705.1 - 0.00097 18.5 0.5 0.0012 18.2 0.5 1.2 1 0 0 1 1 1 1 Plant protein of unknown function C_LFY_FLO PF17538.2 KII73705.1 - 0.043 13.3 2.2 0.093 12.2 1.7 1.7 1 1 1 2 2 2 0 DNA Binding Domain (C-terminal) Leafy/Floricaula PHD PF00628.29 KII73705.1 - 1.1 9.1 22.5 0.25 11.3 16.6 2.5 3 0 0 3 3 3 0 PHD-finger Ribosomal_L9_N PF01281.19 KII73706.1 - 1.1e-12 47.3 0.0 2e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Vint PF14623.6 KII73706.1 - 0.082 12.7 0.0 7.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Hint-domain tRNA-synt_His PF13393.6 KII73707.1 - 3.8e-42 144.6 0.0 4.7e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 KII73707.1 - 3.9e-15 55.8 0.2 8.9e-15 54.6 0.2 1.6 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 KII73707.1 - 6.1e-10 39.1 1.7 9.1e-10 38.5 1.7 1.2 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2b PF00587.25 KII73707.1 - 5.2e-06 26.6 0.0 1.4e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.20 KII73707.1 - 0.0042 16.2 0.1 0.03 13.4 0.0 2.2 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 KII73707.1 - 0.01 15.3 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Ribosomal_L29 PF00831.23 KII73708.1 - 8.7e-15 54.4 5.1 8.7e-15 54.4 5.1 1.7 2 0 0 2 2 2 1 Ribosomal L29 protein Sigma70_ner PF04546.13 KII73708.1 - 0.11 12.3 2.9 0.14 12.1 2.9 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region RIO1 PF01163.22 KII73709.1 - 5e-61 205.6 0.0 5e-61 205.6 0.0 2.1 3 0 0 3 3 3 1 RIO1 family APH PF01636.23 KII73709.1 - 0.00014 21.8 0.0 0.38 10.6 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KII73709.1 - 0.00055 19.4 0.0 0.19 11.0 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KII73709.1 - 0.047 12.5 3.8 0.051 12.4 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase TALPID3 PF15324.6 KII73709.1 - 6.7 4.2 12.3 8.3 3.9 12.3 1.1 1 0 0 1 1 1 0 Hedgehog signalling target DDE_3 PF13358.6 KII73710.1 - 0.00011 22.0 0.0 0.00069 19.4 0.0 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease PAX PF00292.18 KII73710.1 - 0.089 12.7 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 'Paired box' domain DUF5502 PF17606.2 KII73711.1 - 0.081 13.6 0.0 0.22 12.2 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5502) UPF0242 PF06785.11 KII73713.1 - 0.0017 18.5 15.1 0.0017 18.5 15.1 4.0 2 2 1 3 3 3 1 Uncharacterised protein family (UPF0242) N-terminus Mce4_CUP1 PF11887.8 KII73713.1 - 0.0022 17.5 11.6 0.034 13.6 0.6 3.0 2 1 0 3 3 3 2 Cholesterol uptake porter CUP1 of Mce4, putative BLOC1_2 PF10046.9 KII73713.1 - 0.0065 16.8 4.9 0.0065 16.8 4.9 5.5 3 3 2 5 5 5 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 KASH_CCD PF14662.6 KII73713.1 - 0.0084 15.9 15.8 0.0084 15.9 15.8 4.0 2 2 2 4 4 4 1 Coiled-coil region of CCDC155 or KASH TetR_C_13 PF16925.5 KII73713.1 - 0.14 12.1 5.7 0.72 9.8 0.6 3.3 2 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain YtxH PF12732.7 KII73713.1 - 0.28 11.7 9.4 4.3 7.9 0.6 3.8 3 2 0 3 3 3 0 YtxH-like protein APG6_N PF17675.1 KII73713.1 - 6.1 7.4 41.1 1.7 9.1 5.9 4.1 2 1 2 4 4 4 0 Apg6 coiled-coil region DUF5082 PF16888.5 KII73713.1 - 7.5 6.9 31.2 0.5 10.7 2.2 5.4 4 2 1 5 5 5 0 Domain of unknown function (DUF5082) Ig_3 PF13927.6 KII73714.1 - 2.5e-30 104.9 2.4 2.9e-11 43.8 0.0 5.5 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 KII73714.1 - 5.5e-30 103.3 0.4 4.9e-12 45.7 0.0 5.5 6 0 0 6 6 6 5 Immunoglobulin I-set domain ig PF00047.25 KII73714.1 - 1.5e-18 66.8 0.7 4.8e-06 26.7 0.0 5.4 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 KII73714.1 - 3.5e-18 65.8 1.0 3.3e-05 24.0 0.0 5.8 5 1 1 6 6 6 3 Immunoglobulin V-set domain Ig_2 PF13895.6 KII73714.1 - 8.4e-14 51.7 0.8 0.00039 20.7 0.0 4.8 5 0 0 5 5 5 3 Immunoglobulin domain fn3 PF00041.21 KII73714.1 - 5e-10 39.6 1.1 1.4e-09 38.2 0.2 2.3 2 0 0 2 2 2 1 Fibronectin type III domain Ig_6 PF18452.1 KII73714.1 - 2.5e-07 30.2 0.2 0.014 15.0 0.0 4.4 7 0 0 7 7 7 2 Immunoglobulin domain C2-set_2 PF08205.12 KII73714.1 - 1.8e-05 24.7 0.1 0.45 10.6 0.0 3.4 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 KII73714.1 - 0.003 18.1 0.1 0.01 16.4 0.1 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.5 KII73714.1 - 0.0032 17.5 0.1 11 6.1 0.0 4.2 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 KII73714.1 - 0.071 13.4 0.0 7.1 7.0 0.0 2.6 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Herpes_gE PF02480.16 KII73714.1 - 0.23 10.2 0.6 0.83 8.3 0.0 2.2 2 1 1 3 3 3 0 Alphaherpesvirus glycoprotein E C-C_Bond_Lyase PF15617.6 KII73717.1 - 0.019 14.2 0.1 0.024 13.8 0.1 1.1 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold Cyclin_C PF02984.19 KII73717.1 - 0.075 13.1 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Cyclin, C-terminal domain Sortilin-Vps10 PF15902.5 KII73720.1 - 6.3e-11 41.7 4.4 3.2e-10 39.4 4.4 2.4 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII73720.1 - 1.9e-07 31.6 1.0 4e-07 30.5 1.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII73720.1 - 0.05 13.6 4.5 0.23 11.6 0.2 3.8 4 0 0 4 4 4 0 BNR/Asp-box repeat Sortilin_C PF15901.5 KII73721.1 - 1.2e-14 55.0 2.3 1.5e-14 54.7 2.3 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII73722.1 - 3.4e-08 32.7 0.5 4.7e-08 32.3 0.5 1.4 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII73722.1 - 1.5e-06 27.3 0.5 0.03 14.3 0.0 3.7 3 0 0 3 3 3 2 BNR/Asp-box repeat RVP PF00077.20 KII73723.1 - 0.011 16.0 0.0 0.031 14.6 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII73723.1 - 0.012 16.1 0.0 0.086 13.4 0.0 2.4 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease MadM PF03818.13 KII73724.1 - 0.083 12.8 0.1 0.16 11.8 0.1 1.6 1 1 0 1 1 1 0 Malonate/sodium symporter MadM subunit Neurensin PF14927.6 KII73724.1 - 0.11 12.1 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Neurensin NUP214 PF16755.5 KII73725.1 - 0.027 13.7 2.4 0.052 12.8 0.5 1.8 1 1 1 2 2 2 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Sortilin_C PF15901.5 KII73726.1 - 6.8e-15 55.8 0.2 1.3e-14 54.9 0.2 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII73726.1 - 8.4e-10 38.0 3.1 1.8e-09 36.9 1.6 2.1 1 1 1 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII73726.1 - 2e-05 23.9 0.3 0.57 10.4 0.0 3.9 3 0 0 3 3 3 2 BNR/Asp-box repeat MCM_lid PF17855.1 KII73728.1 - 9.6e-17 61.2 0.1 1.5e-16 60.5 0.1 1.3 1 0 0 1 1 1 1 MCM AAA-lid domain EF-hand_14 PF17959.1 KII73728.1 - 0.26 11.7 1.7 0.47 10.8 0.2 2.0 2 0 0 2 2 2 0 EF-hand domain MCM PF00493.23 KII73729.1 - 2.3e-37 128.2 0.0 2.9e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 MCM P-loop domain Mg_chelatase PF01078.21 KII73729.1 - 0.0008 18.8 0.1 0.01 15.2 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KII73729.1 - 0.027 14.3 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ribosomal_L17 PF01196.19 KII73731.1 - 8.2e-13 49.1 0.1 1.1e-12 48.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 DDE_Tnp_IS1595 PF12762.7 KII73733.1 - 1.9e-10 40.9 0.0 2.7e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain ShK PF01549.24 KII73733.1 - 0.053 14.1 0.1 0.1 13.1 0.1 1.5 1 0 0 1 1 1 0 ShK domain-like CAP PF00188.26 KII73735.1 - 1.7e-25 90.3 0.0 2.6e-17 63.8 0.0 2.6 2 1 0 2 2 2 2 Cysteine-rich secretory protein family GCOM2 PF15328.6 KII73735.1 - 0.11 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 Vps35 PF03635.17 KII73736.1 - 3.5e-20 72.1 4.0 4.7e-20 71.7 4.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 RIX1 PF08167.12 KII73736.1 - 0.00012 21.9 0.7 0.0016 18.3 0.2 2.7 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis YoaP PF14268.6 KII73736.1 - 0.013 15.0 0.1 0.027 14.0 0.1 1.5 1 0 0 1 1 1 0 YoaP-like zf-C3Hc3H PF13891.6 KII73736.1 - 0.22 11.9 3.0 9.2 6.7 0.5 2.7 2 0 0 2 2 2 0 Potential DNA-binding domain Vps35 PF03635.17 KII73737.1 - 3.8e-11 42.2 2.0 5.6e-11 41.7 2.0 1.4 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Pribosyltran PF00156.27 KII73740.1 - 4.1e-20 71.9 0.1 5.8e-20 71.4 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KII73740.1 - 0.0001 21.8 0.0 0.0064 15.9 0.0 2.1 2 0 0 2 2 2 2 Uracil phosphoribosyltransferase DDE_Tnp_1_7 PF13843.6 KII73741.1 - 0.0031 16.9 0.3 0.004 16.5 0.3 1.1 1 0 0 1 1 1 1 Transposase IS4 Dimer_Tnp_hAT PF05699.14 KII73747.1 - 9.3e-07 28.6 0.4 0.00025 20.8 0.0 2.2 1 1 1 2 2 2 2 hAT family C-terminal dimerisation region DEAD PF00270.29 KII73748.1 - 9.2e-47 159.1 0.1 2.3e-46 157.7 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII73748.1 - 2.3e-23 82.6 0.1 1.7e-21 76.7 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KII73748.1 - 1.9e-13 50.4 0.0 5.5e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KII73748.1 - 4.8e-12 46.2 1.0 9.9e-12 45.2 0.1 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KII73748.1 - 0.00042 20.6 0.3 0.0012 19.1 0.3 1.7 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.6 KII73748.1 - 0.031 13.6 1.4 0.043 13.2 0.1 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_11 PF13086.6 KII73748.1 - 0.036 13.9 0.1 0.45 10.3 0.0 2.3 1 1 1 2 2 2 0 AAA domain Helicase_RecD PF05127.14 KII73748.1 - 0.088 12.7 0.0 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 Helicase DEAD PF00270.29 KII73749.1 - 4.7e-27 94.9 0.1 5.6e-27 94.6 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KII73749.1 - 0.00023 21.2 0.0 0.00024 21.1 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 KII73749.1 - 0.084 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain ShK PF01549.24 KII73750.1 - 1.4e-06 28.7 9.3 2.3e-06 28.0 9.3 1.4 1 0 0 1 1 1 1 ShK domain-like Torsin PF06309.11 KII73750.1 - 0.13 12.4 0.2 0.19 11.8 0.2 1.2 1 0 0 1 1 1 0 Torsin DUF2659 PF10858.8 KII73751.1 - 0.00014 21.6 0.3 0.00035 20.3 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2659) CBM_21 PF03370.13 KII73751.1 - 0.078 13.2 0.1 0.2 11.8 0.1 1.8 1 1 0 1 1 1 0 Carbohydrate/starch-binding module (family 21) PA14 PF07691.12 KII73751.1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 PA14 domain CALM_bind PF16025.5 KII73753.1 - 0.0013 19.1 2.0 0.0013 19.1 2.0 2.4 1 1 1 2 2 2 1 Calcium-dependent calmodulin binding SHE3 PF17078.5 KII73753.1 - 0.0023 17.7 2.2 0.0031 17.3 2.2 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 DUF4200 PF13863.6 KII73753.1 - 0.0045 17.4 2.6 0.0045 17.4 2.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) Phage_Mu_Gam PF07352.12 KII73753.1 - 0.0092 15.9 2.7 0.016 15.1 2.7 1.3 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein DUF3450 PF11932.8 KII73753.1 - 0.038 13.3 0.1 0.052 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CASP_C PF08172.12 KII73753.1 - 0.16 11.3 5.2 0.58 9.5 2.0 2.2 2 1 0 2 2 2 0 CASP C terminal DivIC PF04977.15 KII73753.1 - 2.6 7.9 7.9 0.077 12.8 1.7 1.6 2 0 0 2 2 2 0 Septum formation initiator AHD PF17793.1 KII73754.1 - 0.057 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 ANC1 homology domain (AHD) Kelch_6 PF13964.6 KII73757.1 - 1.4e-21 76.0 5.8 1.7e-06 28.1 0.5 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII73757.1 - 2.2e-14 53.3 1.1 7.7e-06 26.1 0.1 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73757.1 - 7.6e-14 51.0 2.5 8.3e-06 25.3 1.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII73757.1 - 4.1e-09 36.2 8.6 0.0017 18.3 0.2 3.5 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII73757.1 - 2.4e-08 33.9 7.5 0.0043 17.0 0.0 3.7 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII73757.1 - 6.6e-06 25.9 3.3 0.024 14.6 0.1 2.9 3 0 0 3 3 3 2 Kelch motif AA_permease_C PF13906.6 KII73757.1 - 4.5 7.4 9.8 1.6 8.8 0.1 3.4 4 0 0 4 4 4 0 C-terminus of AA_permease Kelch_6 PF13964.6 KII73758.1 - 0.18 12.1 1.2 3 8.3 0.1 2.2 1 1 1 2 2 2 0 Kelch motif WD40_like PF17005.5 KII73760.1 - 7.4e-07 28.8 0.1 1.8e-05 24.2 0.0 2.1 1 1 1 2 2 2 2 WD40-like domain WD40 PF00400.32 KII73760.1 - 3.8e-06 27.5 7.1 0.27 12.2 0.0 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat eIF2A PF08662.11 KII73760.1 - 0.0019 18.1 0.3 0.097 12.5 0.0 2.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 KII73760.1 - 0.023 15.0 0.3 4 7.8 0.0 3.4 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2649 PF10854.8 KII73761.1 - 0.024 14.9 7.9 0.038 14.3 7.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2649) Baculo_11_kDa PF06143.11 KII73761.1 - 0.65 9.6 7.0 1.1 8.9 6.5 1.6 1 1 1 2 2 2 0 Baculovirus 11 kDa family DUF1639 PF07797.14 KII73764.1 - 0.36 10.9 0.2 0.36 10.9 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1639) Mitofilin PF09731.9 KII73764.1 - 1.7 7.4 6.9 3.2 6.5 6.9 1.4 1 0 0 1 1 1 0 Mitochondrial inner membrane protein NinE PF05322.11 KII73764.1 - 3.9 7.4 9.0 23 5.0 0.1 3.6 3 0 0 3 3 3 0 NINE Protein Peptidase_S8 PF00082.22 KII73767.1 - 2.6e-31 109.0 0.2 4e-31 108.4 0.2 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KII73767.1 - 6.6e-15 54.9 0.1 1.4e-14 53.9 0.1 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain CPBP PF02517.16 KII73768.1 - 0.0036 17.6 0.1 0.0059 17.0 0.1 1.4 1 0 0 1 1 1 1 CPBP intramembrane metalloprotease Acetyltransf_4 PF13420.7 KII73769.1 - 0.033 14.3 0.2 0.045 13.9 0.2 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Rogdi_lz PF10259.9 KII73770.1 - 1.6e-08 34.3 0.1 1.9e-08 34.1 0.1 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein COG2 PF06148.11 KII73771.1 - 4.2e-07 30.1 5.6 9.1e-07 29.0 5.6 1.7 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Prefoldin_2 PF01920.20 KII73771.1 - 4.6e-05 23.3 2.4 4.6e-05 23.3 2.4 1.6 2 0 0 2 2 2 1 Prefoldin subunit CorA PF01544.18 KII73771.1 - 0.0019 17.6 3.7 0.0021 17.5 3.7 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein APG6_N PF17675.1 KII73771.1 - 0.0067 17.0 7.0 0.0088 16.6 7.0 1.3 1 1 0 1 1 1 1 Apg6 coiled-coil region Uds1 PF15456.6 KII73771.1 - 0.01 16.0 0.4 0.015 15.5 0.4 1.3 1 0 0 1 1 1 0 Up-regulated During Septation Mod_r PF07200.13 KII73771.1 - 0.011 15.8 4.4 0.014 15.5 4.4 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein PspA_IM30 PF04012.12 KII73771.1 - 0.011 15.3 0.6 0.011 15.3 0.6 1.2 1 0 0 1 1 1 0 PspA/IM30 family FliD_C PF07195.12 KII73771.1 - 0.016 14.7 0.7 0.019 14.4 0.7 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF4446 PF14584.6 KII73771.1 - 0.018 15.0 1.0 0.023 14.7 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) TolA_bind_tri PF16331.5 KII73771.1 - 0.021 14.9 2.0 0.021 14.9 2.0 1.7 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF1664 PF07889.12 KII73771.1 - 0.023 14.7 1.0 0.042 13.9 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3490 PF11995.8 KII73771.1 - 0.023 14.5 0.9 0.031 14.1 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) DivIC PF04977.15 KII73771.1 - 0.03 14.1 2.3 0.03 14.1 2.3 1.7 2 0 0 2 2 2 0 Septum formation initiator FapA PF03961.13 KII73771.1 - 0.032 12.8 2.9 0.035 12.7 2.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FliJ PF02050.16 KII73771.1 - 0.033 14.4 2.2 0.052 13.8 2.2 1.5 1 1 0 1 1 1 0 Flagellar FliJ protein Prominin PF05478.11 KII73771.1 - 0.034 12.1 1.4 0.036 12.0 1.4 1.0 1 0 0 1 1 1 0 Prominin Prefoldin PF02996.17 KII73771.1 - 0.035 14.0 4.5 0.045 13.7 2.9 1.9 1 1 0 2 2 2 0 Prefoldin subunit bZIP_1 PF00170.21 KII73771.1 - 0.038 14.1 7.1 0.079 13.1 2.0 3.0 2 2 0 2 2 2 0 bZIP transcription factor Syntaxin-6_N PF09177.11 KII73771.1 - 0.04 14.5 2.5 0.066 13.8 1.7 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF4449 PF14613.6 KII73771.1 - 0.048 13.8 0.3 0.061 13.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) HMMR_N PF15905.5 KII73771.1 - 0.052 13.0 4.8 0.061 12.8 4.8 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Nas2_N PF18265.1 KII73771.1 - 0.052 13.5 1.8 0.076 12.9 0.8 1.8 2 0 0 2 2 2 0 Nas2 N_terminal domain Fzo_mitofusin PF04799.13 KII73771.1 - 0.054 13.0 0.7 0.067 12.7 0.7 1.2 1 0 0 1 1 1 0 fzo-like conserved region CCDC-167 PF15188.6 KII73771.1 - 0.06 13.7 4.4 0.2 12.0 4.4 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 CENP-F_leu_zip PF10473.9 KII73771.1 - 0.064 13.3 6.6 0.051 13.6 3.6 1.9 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 4HB_MCP_1 PF12729.7 KII73771.1 - 0.072 12.6 5.3 0.11 12.0 5.3 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction DUF4407 PF14362.6 KII73771.1 - 0.075 12.4 0.5 0.083 12.2 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Rootletin PF15035.6 KII73771.1 - 0.075 13.1 2.6 0.093 12.7 2.6 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion NuA4 PF09340.10 KII73771.1 - 0.078 12.9 1.2 0.14 12.1 1.2 1.4 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 DDE_Tnp_IS240 PF13610.6 KII73771.1 - 0.086 13.1 0.6 0.42 10.8 0.2 1.9 1 1 1 2 2 2 0 DDE domain DUF4200 PF13863.6 KII73771.1 - 0.097 13.1 4.5 0.16 12.4 4.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Vps51 PF08700.11 KII73771.1 - 0.1 12.7 3.1 8.8 6.5 0.0 2.5 1 1 1 2 2 2 0 Vps51/Vps67 COG5 PF10392.9 KII73771.1 - 0.14 12.3 6.1 0.26 11.5 6.1 1.4 1 1 0 1 1 1 0 Golgi transport complex subunit 5 DUF4635 PF15466.6 KII73771.1 - 0.29 10.6 3.6 0.37 10.3 1.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4635) DUF4795 PF16043.5 KII73771.1 - 0.43 10.2 6.9 0.67 9.5 4.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) MCC-bdg_PDZ PF10506.9 KII73771.1 - 0.45 10.6 3.5 0.47 10.5 0.4 2.4 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome FlaC_arch PF05377.11 KII73771.1 - 0.58 10.6 6.0 0.23 11.9 1.3 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Cnn_1N PF07989.11 KII73771.1 - 2.8 8.2 11.7 21 5.4 11.7 2.2 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Serpin PF00079.20 KII73772.1 - 1.3e-26 93.8 1.0 1.5e-23 83.8 0.2 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) DDE_Tnp_IS1595 PF12762.7 KII73773.1 - 6.7e-15 55.4 0.0 9.7e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain MF_alpha_N PF05436.11 KII73773.1 - 0.22 11.4 0.0 0.41 10.6 0.0 1.3 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus DDE_Tnp_IS1595 PF12762.7 KII73777.1 - 9.3e-13 48.5 0.0 3.8e-06 27.0 0.0 2.6 2 1 0 2 2 2 2 ISXO2-like transposase domain ADAM_spacer1 PF05986.14 KII73780.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 ADAM-TS Spacer 1 FANCI_S2 PF14676.6 KII73781.1 - 0.019 15.3 0.4 0.023 15.0 0.4 1.1 1 0 0 1 1 1 0 FANCI solenoid 2 DUF4042 PF13251.6 KII73781.1 - 0.025 14.3 0.3 0.042 13.5 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) V-ATPase_H_C PF11698.8 KII73781.1 - 0.16 12.1 2.3 1.4 9.0 0.1 2.1 1 1 1 2 2 2 0 V-ATPase subunit H DIM1 PF02966.16 KII73784.1 - 1.7e-63 212.3 0.2 1.9e-63 212.2 0.2 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 KII73784.1 - 0.00018 21.4 0.1 0.00024 21.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KII73784.1 - 0.011 15.8 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredox_DsbH PF03190.15 KII73784.1 - 0.035 14.1 0.2 0.058 13.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 ALS_ss_C PF10369.9 KII73784.1 - 0.076 13.2 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Small subunit of acetolactate synthase DDE_3 PF13358.6 KII73788.1 - 1.5e-09 37.7 0.2 2.1e-08 34.0 0.0 2.5 2 1 1 3 3 3 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.11 KII73788.1 - 0.018 14.0 0.0 0.023 13.7 0.0 1.3 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain CheY-binding PF09078.11 KII73790.1 - 0.16 12.1 0.3 0.59 10.3 0.0 1.9 2 0 0 2 2 2 0 CheY binding ComS PF17584.2 KII73793.1 - 0.97 9.0 4.7 1.5 8.4 0.7 2.9 2 0 0 2 2 2 0 Bacillus competence protein S UFC1 PF08694.11 KII73794.1 - 2.6e-70 235.0 0.1 2.9e-70 234.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 KII73794.1 - 0.0021 18.3 0.0 0.0026 18.0 0.0 1.2 1 0 0 1 1 1 1 RWD domain UQ_con PF00179.26 KII73794.1 - 0.06 13.0 0.1 0.072 12.7 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Helicase_C PF00271.31 KII73795.1 - 3.3e-23 82.1 0.5 3.2e-22 79.0 0.1 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII73795.1 - 2e-21 76.7 1.5 8.7e-21 74.7 0.0 2.7 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KII73795.1 - 6.3e-20 71.7 0.0 3.3e-19 69.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KII73795.1 - 0.085 13.1 0.0 0.42 10.9 0.0 2.2 1 0 0 1 1 1 0 AAA domain UPF0121 PF03661.13 KII73797.1 - 1.2e-33 116.6 12.9 1.3e-33 116.4 12.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Rad9_Rad53_bind PF08605.10 KII73797.1 - 0.07 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Fungal Rad9-like Rad53-binding Seryl_tRNA_N PF02403.22 KII73800.1 - 0.011 16.0 1.7 0.011 16.0 1.7 1.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DDE_3 PF13358.6 KII73801.1 - 8.7e-31 106.6 0.0 1.3e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII73801.1 - 4e-07 30.2 0.1 1.3e-05 25.3 0.1 2.4 2 0 0 2 2 2 1 Transposase rve PF00665.26 KII73801.1 - 0.00041 20.5 0.0 0.0011 19.2 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain HTH_24 PF13412.6 KII73801.1 - 0.0044 16.6 1.1 0.19 11.3 0.0 2.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_33 PF13592.6 KII73801.1 - 0.049 13.3 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix HTH_23 PF13384.6 KII73801.1 - 0.052 13.4 0.1 2.1 8.2 0.0 2.7 2 0 0 2 2 2 0 Homeodomain-like domain HTH_32 PF13565.6 KII73801.1 - 0.093 13.4 0.0 1.2 9.8 0.0 2.4 1 1 1 2 2 2 0 Homeodomain-like domain Ribosomal_S6e PF01092.19 KII73805.1 - 3.6e-54 182.0 0.2 7e-54 181.1 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e EF-hand_4 PF12763.7 KII73806.1 - 1.4e-20 73.2 0.1 2.1e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 KII73806.1 - 7.9e-05 21.9 0.1 0.00018 20.8 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KII73806.1 - 0.016 15.1 0.1 0.064 13.2 0.1 2.0 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 KII73806.1 - 0.045 14.2 0.0 0.061 13.8 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 KII73806.1 - 0.057 12.9 0.2 0.11 12.1 0.2 1.4 1 0 0 1 1 1 0 EF hand DUF573 PF04504.14 KII73808.1 - 0.035 14.8 0.8 0.27 11.9 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function, DUF573 GCD14 PF08704.10 KII73808.1 - 0.042 13.5 2.6 0.036 13.8 0.8 1.7 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit DUF5129 PF17173.4 KII73808.1 - 0.055 12.6 0.9 1.3 8.1 0.2 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF5129) DUF1068 PF06364.12 KII73808.1 - 0.18 11.7 5.0 0.62 9.9 0.0 3.5 2 2 2 4 4 4 0 Protein of unknown function (DUF1068) TMPIT PF07851.13 KII73808.1 - 0.5 9.6 5.8 1.5 8.0 2.3 2.3 2 0 0 2 2 2 0 TMPIT-like protein Laminin_II PF06009.12 KII73808.1 - 0.87 9.6 8.5 0.26 11.3 0.3 3.3 2 1 1 3 3 3 0 Laminin Domain II Occludin_ELL PF07303.13 KII73808.1 - 0.9 10.3 7.4 23 5.8 2.1 4.3 3 1 0 3 3 3 0 Occludin homology domain Syntaxin-6_N PF09177.11 KII73808.1 - 6.1 7.5 7.9 6.6 7.4 2.5 3.3 2 1 1 3 3 3 0 Syntaxin 6, N-terminal YabA PF06156.13 KII73808.1 - 8 7.2 10.5 1.6 9.4 3.8 2.7 2 0 0 2 2 2 0 Initiation control protein YabA zf-CCHC PF00098.23 KII73809.1 - 9e-05 22.4 1.8 0.00021 21.2 1.8 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 KII73809.1 - 0.026 14.3 1.1 0.08 12.7 1.1 1.9 1 0 0 1 1 1 0 Zinc knuckle RVP PF00077.20 KII73809.1 - 0.044 14.1 0.0 0.091 13.1 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII73809.1 - 0.079 13.6 0.1 0.18 12.5 0.1 1.6 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 KII73809.1 - 0.14 12.8 0.1 0.31 11.6 0.1 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII73810.1 - 0.048 13.5 0.0 0.071 12.9 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease gag-asp_proteas PF13975.6 KII73810.1 - 0.063 13.8 0.0 0.12 13.0 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RT_RNaseH_2 PF17919.1 KII73811.1 - 5.1e-23 81.0 0.3 9e-21 73.8 0.3 2.5 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII73811.1 - 3.4e-22 78.7 0.1 2e-20 73.0 0.1 2.6 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII73811.1 - 2.9e-16 59.3 0.2 6.3e-16 58.2 0.2 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain RVT_1 PF00078.27 KII73811.1 - 2.6e-15 56.5 0.0 8.2e-15 54.9 0.0 1.9 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII73811.1 - 1.2e-14 54.6 0.0 5.7e-14 52.3 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 KII73811.1 - 0.00083 19.1 0.1 0.0018 18.0 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain tRNA_bind_3 PF17176.4 KII73811.1 - 0.16 12.3 0.1 2.6 8.4 0.0 2.7 3 0 0 3 3 3 0 tRNA-binding domain SNAP PF14938.6 KII73812.1 - 0.0073 15.8 0.0 0.0073 15.8 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Phage_CII PF05269.11 KII73812.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage CII protein HSP20 PF00011.21 KII73814.1 - 7.4e-26 90.3 1.0 2.1e-16 59.9 0.1 2.1 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KII73814.1 - 2.8e-05 23.6 0.0 0.00018 21.0 0.0 2.1 2 0 0 2 2 2 1 HSP20-like domain found in ArsA YabP PF07873.11 KII73814.1 - 0.068 13.0 0.0 6.5 6.6 0.0 2.5 2 0 0 2 2 2 0 YabP family MCM_N PF14551.6 KII73816.1 - 0.074 13.6 0.1 0.099 13.2 0.1 1.3 1 0 0 1 1 1 0 MCM N-terminal domain DDE_3 PF13358.6 KII73817.1 - 7.6e-09 35.5 0.0 9.5e-07 28.7 0.0 2.7 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_23 PF13384.6 KII73817.1 - 7.9e-08 31.9 0.1 1.9e-07 30.7 0.1 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 KII73817.1 - 1e-06 28.0 0.5 1e-06 28.0 0.5 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 PAX PF00292.18 KII73817.1 - 3.2e-05 23.9 0.4 5.5e-05 23.1 0.4 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_1 PF01527.20 KII73817.1 - 6.3e-05 23.2 0.3 0.00011 22.5 0.3 1.4 1 0 0 1 1 1 1 Transposase ubiquitin PF00240.23 KII73817.1 - 0.00019 21.1 0.0 0.00056 19.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family HTH_38 PF13936.6 KII73817.1 - 0.00022 20.9 3.6 0.00022 20.9 3.6 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.13 KII73817.1 - 0.00029 20.4 0.2 0.00071 19.2 0.2 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 KII73817.1 - 0.00061 19.9 0.3 0.0016 18.5 0.3 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII73817.1 - 0.0011 18.6 1.1 0.18 11.5 0.1 2.6 2 0 0 2 2 2 1 Sigma-70, region 4 DUF1323 PF07037.11 KII73817.1 - 0.0058 17.0 0.1 0.013 15.8 0.1 1.6 1 0 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_17 PF12728.7 KII73817.1 - 0.017 15.3 0.5 0.075 13.2 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Rad60-SLD PF11976.8 KII73817.1 - 0.019 14.8 0.1 0.12 12.2 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like HTH_3 PF01381.22 KII73817.1 - 0.05 13.7 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix KORA PF16509.5 KII73817.1 - 0.055 13.8 0.2 0.11 12.8 0.2 1.4 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor HTH_29 PF13551.6 KII73817.1 - 0.071 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix Bot1p PF12298.8 KII73817.1 - 0.13 12.4 1.4 0.23 11.6 1.4 1.3 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein HTH_32 PF13565.6 KII73817.1 - 0.3 11.7 3.7 0.75 10.5 1.6 2.3 1 1 1 2 2 2 0 Homeodomain-like domain Sigma70_r4 PF04545.16 KII73817.1 - 1.3 8.6 3.9 0.91 9.1 0.7 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 Nuc_sug_transp PF04142.15 KII73818.1 - 3.6e-58 197.2 10.4 4.8e-58 196.8 10.4 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KII73818.1 - 1.7e-07 31.4 11.5 3.3e-07 30.5 8.5 2.3 2 1 0 2 2 2 1 EamA-like transporter family UAA PF08449.11 KII73818.1 - 4.7e-07 29.3 3.3 1.5e-06 27.6 2.8 1.9 1 1 1 2 2 2 1 UAA transporter family EmrE PF13536.6 KII73818.1 - 7.7e-05 22.4 1.1 7.7e-05 22.4 1.1 1.6 2 0 0 2 2 2 1 Putative multidrug resistance efflux transporter PUNUT PF16913.5 KII73818.1 - 0.00083 18.7 8.3 0.0015 17.8 8.3 1.4 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport CRT-like PF08627.10 KII73818.1 - 0.0011 18.0 5.2 0.0015 17.6 5.2 1.3 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like ATPase_gene1 PF09527.10 KII73818.1 - 0.074 13.2 3.3 1.9 8.7 0.6 3.3 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter DUF2663 PF10864.8 KII73818.1 - 1.6 9.1 5.8 0.49 10.8 0.2 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2663) RNase_PH PF01138.21 KII73819.1 - 5.1e-11 43.2 0.0 1.3e-10 41.9 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 DUF4079 PF13301.6 KII73819.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) DICT PF10069.9 KII73821.1 - 0.13 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Sensory domain in DIguanylate Cyclases and Two-component system VCBS PF13517.6 KII73823.1 - 1.8e-10 41.3 12.8 1.3e-08 35.3 1.2 2.5 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII73823.1 - 3.4e-08 33.5 10.8 0.0044 17.1 0.0 2.5 2 0 0 2 2 2 2 FG-GAP repeat LMBR1 PF04791.16 KII73824.1 - 0.063 12.2 0.9 0.072 12.0 0.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Cullin_Nedd8 PF10557.9 KII73825.1 - 0.39 10.8 6.4 0.65 10.1 0.2 3.9 4 0 0 4 4 4 0 Cullin protein neddylation domain RVT_1 PF00078.27 KII73830.1 - 1.5e-28 99.9 0.0 2.3e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII73830.1 - 6.8e-05 23.3 0.0 0.00014 22.3 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII73830.1 - 0.0039 17.5 0.0 0.0094 16.2 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII73830.1 - 0.013 16.2 0.0 0.031 14.9 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease DDE_3 PF13358.6 KII73831.1 - 0.00027 20.7 0.0 0.00035 20.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Stealth_CR4 PF17103.5 KII73831.1 - 0.033 14.1 2.1 4 7.4 0.1 2.4 2 0 0 2 2 2 0 Stealth protein CR4, conserved region 4 TMEM132D_C PF15706.5 KII73834.1 - 0.011 15.4 0.3 0.027 14.3 0.0 1.7 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term NSF PF02071.20 KII73836.1 - 0.0073 16.8 1.6 0.18 12.7 0.6 3.0 2 0 0 2 2 2 1 Aromatic-di-Alanine (AdAR) repeat SNAP PF14938.6 KII73836.1 - 0.017 14.5 0.1 0.028 13.9 0.0 1.4 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP NinB PF05772.12 KII73838.1 - 0.038 13.8 0.1 0.058 13.2 0.1 1.4 1 1 0 1 1 1 0 NinB protein Nuc_deoxyri_tr2 PF15891.5 KII73838.1 - 0.1 12.9 0.1 0.15 12.4 0.1 1.2 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like OSTbeta PF15048.6 KII73838.1 - 8.9 6.5 7.3 5.5 7.2 3.3 2.2 1 1 0 2 2 2 0 Organic solute transporter subunit beta protein NinG PF05766.12 KII73839.1 - 0.027 14.4 0.1 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein EGF PF00008.27 KII73841.1 - 3 8.2 10.4 0.15 12.4 4.8 1.8 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 KII73844.1 - 0.00069 20.1 10.1 0.00069 20.1 10.1 3.1 2 1 0 2 2 2 1 Human growth factor-like EGF EGF PF00008.27 KII73844.1 - 0.0015 18.8 9.8 0.0015 18.8 9.8 2.3 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 KII73844.1 - 0.044 14.2 14.7 0.044 14.2 14.7 2.3 2 0 0 2 2 2 0 EGF-like domain HMG_CoA_synt_N PF01154.17 KII73846.1 - 0.091 12.6 0.1 0.78 9.6 0.0 2.1 2 0 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal NumbF PF06311.12 KII73847.1 - 0.073 13.6 0.1 0.11 13.0 0.1 1.4 1 0 0 1 1 1 0 NUMB domain DDE_1 PF03184.19 KII73848.1 - 1.6e-06 27.9 0.2 2.2e-06 27.5 0.2 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease hEGF PF12661.7 KII73849.1 - 0.01 16.5 7.7 0.01 16.5 7.7 3.1 2 1 0 2 2 2 1 Human growth factor-like EGF EGF PF00008.27 KII73849.1 - 0.025 14.9 11.0 0.025 14.9 11.0 2.2 2 0 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 KII73849.1 - 1.7 9.1 28.9 0.47 10.9 16.0 2.3 2 0 0 2 2 2 0 EGF-like domain AA_synth PF06684.11 KII73850.1 - 0.09 12.3 0.0 0.21 11.1 0.0 1.5 2 0 0 2 2 2 0 Amino acid synthesis Orthopox_F6 PF06601.12 KII73851.1 - 0.019 15.1 0.6 1.7 8.8 0.1 2.8 3 0 0 3 3 3 0 Orthopoxvirus F6 protein hEGF PF12661.7 KII73852.1 - 0.00069 20.1 10.1 0.00069 20.1 10.1 3.1 2 1 0 2 2 2 1 Human growth factor-like EGF EGF PF00008.27 KII73852.1 - 0.0015 18.8 9.8 0.0015 18.8 9.8 2.3 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 KII73852.1 - 0.044 14.2 14.7 0.044 14.2 14.7 2.3 2 0 0 2 2 2 0 EGF-like domain DDE_1 PF03184.19 KII73853.1 - 0.037 13.7 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Arabino_trans_C PF14896.6 KII73853.1 - 0.1 11.6 0.1 0.13 11.3 0.1 1.1 1 0 0 1 1 1 0 EmbC C-terminal domain DDE_3 PF13358.6 KII73855.1 - 0.0046 16.7 0.0 0.012 15.3 0.0 1.6 1 1 1 2 2 2 1 DDE superfamily endonuclease Latrophilin PF02354.16 KII73857.1 - 0.0044 16.1 0.7 0.007 15.5 0.5 1.3 1 1 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region Imm9 PF15587.6 KII73857.1 - 0.057 13.1 0.2 0.087 12.5 0.2 1.3 1 0 0 1 1 1 0 Immunity protein 9 RNA_pol_L PF01193.24 KII73860.1 - 5.8e-22 76.9 0.0 8.1e-22 76.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 KII73860.1 - 7.2e-18 65.0 0.0 1.4e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain Phage_BR0599 PF09356.10 KII73860.1 - 0.037 14.4 0.0 0.54 10.6 0.0 2.2 2 0 0 2 2 2 0 Phage conserved hypothetical protein BR0599 CAP PF00188.26 KII73861.1 - 7.8e-24 84.9 0.0 4.2e-16 59.9 0.1 2.7 2 1 0 2 2 2 2 Cysteine-rich secretory protein family HSP20 PF00011.21 KII73862.1 - 6.7e-17 61.5 0.0 2.7e-11 43.5 0.0 2.0 1 1 1 2 2 2 2 Hsp20/alpha crystallin family TPT PF03151.16 KII73863.1 - 6.5e-11 42.1 13.1 7.4e-11 41.9 13.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family VIT1 PF01988.19 KII73863.1 - 1.6 8.5 9.2 0.091 12.6 1.2 2.2 1 1 0 2 2 2 0 VIT family LapA_dom PF06305.11 KII73863.1 - 5.6 6.8 13.2 0.28 11.0 0.5 3.3 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DDE_Tnp_IS1595 PF12762.7 KII73864.1 - 2.9e-09 37.1 0.1 4.2e-09 36.6 0.1 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII73866.1 - 1e-05 25.6 0.3 3.4e-05 23.9 0.3 2.0 1 1 0 1 1 1 1 ISXO2-like transposase domain HTH_11 PF08279.12 KII73867.1 - 0.22 11.5 0.3 0.46 10.5 0.3 1.5 1 0 0 1 1 1 0 HTH domain GTP_EFTU PF00009.27 KII73869.1 - 5.9e-16 58.6 0.2 7e-16 58.3 0.2 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KII73870.1 - 7e-07 29.6 0.7 1e-06 29.1 0.7 1.2 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KII73870.1 - 0.093 12.8 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Elongation Factor G, domain II LepA_C PF06421.12 KII73871.1 - 3e-26 91.7 0.0 3.5e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus RT_RNaseH_2 PF17919.1 KII73876.1 - 1.6e-35 121.1 0.2 3e-34 117.1 0.0 3.0 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII73876.1 - 1.6e-34 118.3 0.0 2.4e-33 114.5 0.0 2.7 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII73876.1 - 2.1e-21 76.5 0.1 8.2e-21 74.5 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII73876.1 - 2.3e-20 72.9 0.0 6.7e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII73876.1 - 4.2e-18 65.2 0.1 9e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII73876.1 - 1.3e-06 28.1 0.2 3.4e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII73876.1 - 0.0077 16.4 0.2 0.025 14.8 0.0 2.0 2 0 0 2 2 2 1 H2C2 zinc finger RICH PF05062.12 KII73876.1 - 0.23 11.8 3.8 1.1 9.7 1.6 2.6 2 0 0 2 2 2 0 RICH domain BrkDBD PF09607.10 KII73877.1 - 0.072 12.9 0.0 0.17 11.6 0.0 1.6 1 1 0 1 1 1 0 Brinker DNA-binding domain Xpo1 PF08389.12 KII73877.1 - 0.19 11.8 2.3 1.5 8.9 0.4 3.2 2 1 1 3 3 3 0 Exportin 1-like protein Hemerythrin PF01814.23 KII73879.1 - 1.9e-22 80.3 3.1 2.6e-22 79.9 3.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain ScdA_N PF04405.14 KII73879.1 - 2e-21 75.4 0.3 3.3e-21 74.7 0.3 1.4 1 0 0 1 1 1 1 Domain of Unknown function (DUF542) RRM_1 PF00076.22 KII73880.1 - 2.6e-33 113.7 4.7 4e-12 45.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hnRNP_Q_AcD PF18360.1 KII73880.1 - 3.1e-06 27.0 0.7 9.8e-06 25.4 0.7 1.9 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain Nup35_RRM_2 PF14605.6 KII73880.1 - 0.00042 20.2 0.5 0.16 12.0 0.1 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 KII73880.1 - 0.01 16.1 1.4 18 5.5 1.2 3.8 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 KII73880.1 - 0.095 12.8 0.5 1.5 9.0 0.0 2.8 3 1 0 3 3 3 0 RNA recognition motif DUF1899 PF08953.11 KII73881.1 - 0.079 12.8 0.2 0.23 11.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1899) DUF4317 PF14199.6 KII73883.1 - 0.0026 17.0 0.1 0.0053 16.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4317) DUF2787 PF10980.8 KII73883.1 - 0.073 13.3 0.3 0.13 12.4 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2787) TraV PF09676.10 KII73887.1 - 0.0081 17.1 0.3 0.011 16.8 0.3 1.2 1 0 0 1 1 1 1 Type IV conjugative transfer system lipoprotein (TraV) TAT_ubiq PF07706.12 KII73887.1 - 0.066 13.4 0.6 0.11 12.8 0.6 1.3 1 0 0 1 1 1 0 Aminotransferase ubiquitination site rve PF00665.26 KII73888.1 - 4.5e-08 33.3 0.0 7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII73888.1 - 0.0045 16.7 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RNase_H_2 PF13482.6 KII73890.1 - 0.022 14.8 0.0 0.051 13.6 0.0 1.6 2 0 0 2 2 2 0 RNase_H superfamily SnAC PF14619.6 KII73894.1 - 0.15 12.7 0.0 0.26 11.9 0.0 1.3 1 0 0 1 1 1 0 Snf2-ATP coupling, chromatin remodelling complex Med28 PF11594.8 KII73897.1 - 0.043 13.9 0.1 0.097 12.8 0.1 1.5 1 0 0 1 1 1 0 Mediator complex subunit 28 Sortilin_C PF15901.5 KII73900.1 - 5.4e-14 52.9 0.9 1.5e-13 51.5 0.9 1.7 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII73900.1 - 0.00015 20.7 2.8 0.00089 18.2 2.2 2.1 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII73900.1 - 0.18 11.9 6.7 0.6 10.3 0.6 3.3 3 0 0 3 3 3 0 BNR/Asp-box repeat AP_endonuc_2_N PF07582.12 KII73901.1 - 0.027 14.2 0.2 0.76 9.5 0.1 2.5 2 0 0 2 2 2 0 AP endonuclease family 2 C terminus Bacillus_HBL PF05791.11 KII73901.1 - 0.22 11.3 2.8 0.42 10.4 1.0 2.0 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Phage_GP20 PF06810.11 KII73901.1 - 0.7 9.7 3.5 8.2 6.2 0.3 2.7 2 1 0 2 2 2 0 Phage minor structural protein GP20 AP_endonuc_2_N PF07582.12 KII73902.1 - 0.0087 15.8 0.0 0.63 9.8 0.1 2.6 2 0 0 2 2 2 2 AP endonuclease family 2 C terminus Ldl_recept_a PF00057.18 KII73903.1 - 4.2e-24 84.5 61.4 4.3e-09 36.5 13.1 4.3 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A RRM_1 PF00076.22 KII73905.1 - 6.2e-47 157.3 0.9 1.1e-18 66.7 0.1 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KII73905.1 - 0.002 18.2 0.7 0.047 13.7 0.1 3.1 3 1 0 3 3 3 1 RNA binding motif RRM_5 PF13893.6 KII73905.1 - 0.0031 17.1 0.4 0.082 12.5 0.1 2.9 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KII73905.1 - 0.074 12.9 0.1 2.6 8.0 0.0 3.3 4 0 0 4 4 4 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KII73905.1 - 0.14 12.2 0.5 6.3 6.9 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif DUF1459 PF07312.11 KII73905.1 - 0.18 12.1 1.6 0.4 10.9 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1459) DUF1828 PF08861.10 KII73906.1 - 0.014 15.7 0.8 0.27 11.5 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function DUF1828 RVT_1 PF00078.27 KII73907.1 - 4.6e-18 65.5 0.0 8.3e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII73907.1 - 1.6e-07 31.2 0.0 2.9e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Cys_rich_FGFR PF00839.17 KII73907.1 - 0.037 14.2 1.0 1.8 8.8 0.1 2.4 2 0 0 2 2 2 0 Cysteine rich repeat DNA_pol_viral_C PF00336.18 KII73907.1 - 0.15 11.4 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain RVT_1 PF00078.27 KII73908.1 - 2.3e-08 33.9 0.0 3.7e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII73908.1 - 3.9e-05 23.6 0.0 7.2e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII73908.1 - 0.0024 18.2 0.0 0.0053 17.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase MULE PF10551.9 KII73913.1 - 0.14 12.6 0.0 0.44 11.0 0.0 1.9 1 0 0 1 1 1 0 MULE transposase domain RRM_1 PF00076.22 KII73916.1 - 2.5e-20 72.1 0.2 5.8e-20 70.9 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KII73916.1 - 0.0027 17.7 0.1 0.0064 16.5 0.1 1.7 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 KII73916.1 - 0.097 12.7 0.4 0.3 11.1 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif rve PF00665.26 KII73917.1 - 1.3e-08 35.1 0.0 2.8e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain SLT_L PF14718.6 KII73917.1 - 0.0088 16.2 1.4 3.1 8.0 0.1 2.8 3 0 0 3 3 3 2 Soluble lytic murein transglycosylase L domain TRAPPC10 PF12584.8 KII73917.1 - 0.013 15.2 0.3 0.021 14.5 0.3 1.4 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 RAC_head PF16717.5 KII73917.1 - 4.8 8.2 10.8 4.4 8.4 0.1 3.0 3 0 0 3 3 3 0 Ribosome-associated complex head domain DDE_1 PF03184.19 KII73918.1 - 0.00011 21.9 0.0 0.00023 20.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Filamin PF00630.19 KII73918.1 - 0.014 16.2 0.2 0.3 11.9 0.2 2.3 1 1 0 1 1 1 0 Filamin/ABP280 repeat ThiJ_like PF17124.5 KII73918.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 ThiJ/PfpI family-like GAGE PF05831.11 KII73918.1 - 0.021 15.4 0.9 0.11 13.1 0.9 2.1 1 1 0 1 1 1 0 GAGE protein Cortex-I_coil PF09304.10 KII73919.1 - 0.023 14.9 0.3 0.054 13.7 0.0 1.6 2 0 0 2 2 2 0 Cortexillin I, coiled coil RRM_1 PF00076.22 KII73920.1 - 4.3e-48 161.0 1.1 7.6e-20 70.5 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KII73920.1 - 0.00029 20.4 1.3 0.078 12.6 0.1 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KII73920.1 - 0.00042 20.3 0.4 0.012 15.7 0.1 3.0 3 0 0 3 3 3 1 RNA binding motif RRM_occluded PF16842.5 KII73920.1 - 0.029 14.2 0.0 2.5 8.0 0.0 3.6 4 1 0 4 4 4 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KII73920.1 - 0.039 14.0 0.4 2 8.4 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Kelch_1 PF01344.25 KII73925.1 - 0.0017 17.9 0.0 0.73 9.5 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII73925.1 - 0.0037 17.2 0.1 0.28 11.2 0.0 2.3 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KII73925.1 - 0.042 14.2 0.4 0.64 10.4 0.0 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 KII73926.1 - 2.9e-16 59.1 3.4 1.3e-05 25.3 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII73926.1 - 5.7e-15 55.1 0.2 0.00011 22.1 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73926.1 - 6.1e-14 51.3 1.1 1.5e-06 27.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII73926.1 - 2.1e-10 40.6 0.1 4e-05 23.8 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII73926.1 - 4.5e-07 29.7 4.0 0.12 12.4 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KII73926.1 - 1.4e-06 28.0 2.0 0.0076 16.2 0.0 3.3 3 0 0 3 3 3 2 Kelch motif FBA_3 PF08268.12 KII73926.1 - 0.064 13.2 0.1 0.36 10.8 0.0 2.1 2 1 1 3 3 3 0 F-box associated domain rve PF00665.26 KII73929.1 - 3.7e-08 33.6 0.0 1.2e-07 31.9 0.0 1.8 1 1 1 2 2 2 1 Integrase core domain rRNA_proc-arch PF13234.6 KII73929.1 - 0.051 13.5 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 rRNA-processing arch domain Ribosomal_S13_N PF08069.12 KII73930.1 - 1e-27 95.9 0.1 1.8e-27 95.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 KII73930.1 - 4.4e-16 58.9 0.6 6.4e-16 58.3 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 LicD PF04991.13 KII73933.1 - 1.2e-07 32.1 0.2 1.1e-06 29.0 0.3 2.0 1 1 1 2 2 2 1 LicD family RhoGEF PF00621.20 KII73934.1 - 1.5e-34 119.8 7.7 1.5e-34 119.8 7.7 2.0 2 0 0 2 2 2 1 RhoGEF domain PTCB-BRCT PF12738.7 KII73934.1 - 6.1e-15 54.9 0.0 1.3e-07 31.4 0.0 3.3 3 0 0 3 3 3 2 twin BRCT domain BRCT PF00533.26 KII73934.1 - 1.7e-10 41.1 0.0 0.00031 21.0 0.0 3.1 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KII73934.1 - 5.4e-08 33.1 0.0 0.00023 21.5 0.0 2.9 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 KII73934.1 - 0.0003 21.0 0.4 2 8.8 0.0 3.9 2 1 1 3 3 3 2 DNA ligase 3 BRCT domain GcnA_N PF18229.1 KII73934.1 - 0.04 13.9 0.0 0.14 12.2 0.0 1.9 1 0 0 1 1 1 0 N-acetyl-beta-D-glucosaminidase N-terminal domain RecQ_Zn_bind PF16124.5 KII73934.1 - 0.59 10.9 4.2 1 10.2 0.1 3.0 3 0 0 3 3 3 0 RecQ zinc-binding WD40 PF00400.32 KII73935.1 - 0.066 14.1 1.5 3.1 8.8 1.5 2.7 1 1 0 1 1 1 0 WD domain, G-beta repeat LisH PF08513.11 KII73936.1 - 1.5e-05 24.7 0.2 3.9e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 LisH FHIPEP PF00771.20 KII73936.1 - 0.022 13.3 0.0 0.029 12.9 0.0 1.1 1 0 0 1 1 1 0 FHIPEP family CSD PF00313.22 KII73937.1 - 5.9e-18 64.5 0.0 9e-18 63.9 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KII73937.1 - 0.00071 19.2 0.1 0.021 14.5 0.1 2.5 1 1 0 1 1 1 1 Ribonuclease B OB domain Ribosomal_L29e PF01779.17 KII73937.1 - 0.0017 18.7 0.0 0.0064 16.8 0.0 2.1 1 0 0 1 1 1 1 Ribosomal L29e protein family LIM PF00412.22 KII73941.1 - 1.7e-23 82.6 51.5 9.4e-10 38.6 13.7 3.3 3 0 0 3 3 3 3 LIM domain PDZ PF00595.24 KII73941.1 - 8.3e-12 45.3 0.3 1.6e-11 44.4 0.3 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII73941.1 - 5.7e-08 32.5 0.1 1.2e-07 31.5 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII73941.1 - 2.7e-06 27.6 0.1 5.4e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 PDZ domain DUF4476 PF14771.6 KII73941.1 - 0.044 14.1 4.0 0.15 12.4 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4476) Tetraspanin PF00335.20 KII73942.1 - 1.3e-14 54.5 10.5 1.8e-14 54.0 10.5 1.2 1 0 0 1 1 1 1 Tetraspanin family HTH_Tnp_Tc5 PF03221.16 KII73943.1 - 0.086 12.9 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DUF659 PF04937.15 KII73947.1 - 0.025 14.5 0.5 0.038 13.9 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF 659) Acp26Ab PF05777.12 KII73947.1 - 0.059 14.0 0.7 0.11 13.1 0.1 1.7 2 0 0 2 2 2 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) eIF-3_zeta PF05091.12 KII73947.1 - 0.099 11.6 0.0 0.12 11.3 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Phage_P2_GpU PF06995.11 KII73948.1 - 1.8e-39 134.0 0.1 2.3e-39 133.7 0.1 1.1 1 0 0 1 1 1 1 Phage P2 GpU SIR2_2 PF13289.6 KII73949.1 - 4.5e-10 39.8 0.2 1.7e-09 37.9 0.2 2.1 2 0 0 2 2 2 1 SIR2-like domain AAA_10 PF12846.7 KII73949.1 - 0.0042 16.1 0.0 0.0078 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain IstB_IS21 PF01695.17 KII73949.1 - 0.027 14.2 0.0 0.064 13.0 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 KII73949.1 - 0.033 14.4 0.1 0.3 11.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain Serpin PF00079.20 KII73951.1 - 6.2e-18 65.3 0.7 6.8e-18 65.1 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73952.1 - 3.4e-14 52.9 1.5 4e-14 52.7 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) MOZART1 PF12554.8 KII73952.1 - 0.0035 17.1 1.6 0.92 9.3 0.1 3.0 3 0 0 3 3 3 2 Mitotic-spindle organizing gamma-tubulin ring associated DUF1106 PF06523.11 KII73953.1 - 0.019 15.0 0.1 0.03 14.4 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1106) Dehydratase_MU PF02288.15 KII73953.1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 Dehydratase medium subunit Serpin PF00079.20 KII73954.1 - 2.1e-51 175.4 1.4 2.3e-51 175.2 1.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73955.1 - 2.3e-14 53.5 4.2 2.7e-14 53.2 4.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII73956.1 - 3.9e-43 148.2 1.6 4.4e-43 148.0 1.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) ATP-synt_C PF00137.21 KII73957.1 - 1.4e-18 67.0 13.3 2.1e-18 66.4 13.3 1.3 1 0 0 1 1 1 1 ATP synthase subunit C Orthoreo_P10 PF07204.11 KII73958.1 - 0.12 12.4 0.1 0.25 11.3 0.1 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 MLANA PF14991.6 KII73958.1 - 0.15 12.4 0.1 0.38 11.1 0.1 1.7 1 0 0 1 1 1 0 Protein melan-A SecY PF00344.20 KII73959.1 - 5.5e-22 78.4 0.2 6e-22 78.3 0.2 1.0 1 0 0 1 1 1 1 SecY translocase DUF2976 PF11190.8 KII73959.1 - 0.042 13.7 0.1 0.57 10.0 0.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2976) SecY PF00344.20 KII73960.1 - 2.3e-32 112.5 8.1 2.7e-32 112.2 8.1 1.0 1 0 0 1 1 1 1 SecY translocase Sid-5 PF17204.3 KII73961.1 - 0.094 12.9 1.1 0.25 11.5 1.1 1.7 1 0 0 1 1 1 0 Sid-5 family DUF1180 PF06679.12 KII73961.1 - 0.12 12.8 0.1 0.17 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF1652 PF07865.11 KII73962.1 - 0.013 15.3 0.0 0.037 13.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1652) tRNA-synt_2b PF00587.25 KII73963.1 - 0.034 14.1 0.0 0.038 14.0 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) PIG-P PF08510.12 KII73963.1 - 0.13 12.2 2.5 1.3 9.0 0.2 2.3 2 0 0 2 2 2 0 PIG-P PMT_4TMC PF16192.5 KII73963.1 - 0.31 10.6 3.8 2.9 7.4 0.2 2.2 1 1 1 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase RNA_pol_I_A49 PF06870.12 KII73964.1 - 1.1e-25 90.4 0.1 1.3e-25 90.1 0.1 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor GTP_EFTU PF00009.27 KII73966.1 - 7.1e-28 97.5 0.4 6.1e-27 94.4 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KII73966.1 - 1.9e-19 69.7 0.1 5.9e-19 68.1 0.1 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 KII73966.1 - 3.5e-13 49.3 0.5 9.2e-13 47.9 0.5 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 KII73966.1 - 1.1e-08 35.4 3.3 0.00027 21.3 0.0 3.2 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KII73966.1 - 1.3e-07 31.7 0.0 5.5e-07 29.7 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 KII73966.1 - 0.0035 17.5 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 KII73966.1 - 0.0051 16.3 1.2 0.19 11.3 1.2 2.9 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 KII73966.1 - 0.016 15.0 0.7 0.077 12.8 0.0 2.4 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 KII73966.1 - 0.037 14.3 0.2 0.32 11.2 0.2 2.5 1 1 0 1 1 1 0 AAA domain CDC27 PF09507.10 KII73966.1 - 1.3 8.3 29.2 2.2 7.6 29.2 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4770 PF15994.5 KII73966.1 - 3.6 7.8 12.8 9.5 6.4 12.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DDHD PF02862.17 KII73966.1 - 4.3 7.4 6.0 9.8 6.3 6.0 1.6 1 0 0 1 1 1 0 DDHD domain DUF5401 PF17380.2 KII73966.1 - 6.8 4.6 28.9 10 4.1 28.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Atrophin-1 PF03154.15 KII73966.1 - 9.9 4.3 10.8 16 3.6 10.8 1.3 1 0 0 1 1 1 0 Atrophin-1 family WD40 PF00400.32 KII73968.1 - 1.1e-15 57.7 16.8 3.6e-06 27.6 0.8 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII73968.1 - 1.4e-13 50.9 2.4 6e-05 23.3 0.0 4.2 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KII73968.1 - 8.4e-10 38.8 0.1 9.1e-06 25.7 0.1 2.4 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 KII73968.1 - 0.0014 18.0 0.2 0.077 12.3 0.1 2.3 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal RAB3GAP2_N PF14655.6 KII73968.1 - 0.011 15.0 0.2 0.022 14.1 0.0 1.5 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Ge1_WD40 PF16529.5 KII73968.1 - 0.081 11.9 0.0 1.1 8.2 0.0 2.5 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FTCD_C PF04961.12 KII73970.1 - 0.089 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Spermine_synth PF01564.17 KII73972.1 - 7.2e-40 136.4 1.4 2e-34 118.6 0.2 2.5 1 1 1 2 2 2 2 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KII73972.1 - 6e-16 58.1 0.2 1.2e-15 57.1 0.2 1.6 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KII73972.1 - 0.0019 18.9 0.0 0.0034 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 KII73972.1 - 0.039 13.6 0.1 0.12 12.0 0.1 1.7 1 1 1 2 2 2 0 Methionine biosynthesis protein MetW Methyltransf_30 PF05430.11 KII73972.1 - 0.087 12.7 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase baeRF_family5 PF18846.1 KII73973.1 - 0.073 13.3 0.6 0.22 11.7 0.1 1.9 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 DUF1759 PF03564.15 KII73974.1 - 0.004 17.1 2.2 0.0061 16.5 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) DUF2207 PF09972.9 KII73974.1 - 0.5 9.1 6.2 0.58 8.8 0.9 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Synaptobrevin PF00957.21 KII73974.1 - 2.8 7.8 11.7 42 4.0 11.7 2.4 1 1 0 1 1 1 0 Synaptobrevin YiaAB PF05360.14 KII73975.1 - 0.16 12.3 2.3 0.23 11.7 2.3 1.3 1 0 0 1 1 1 0 yiaA/B two helix domain DUF2427 PF10348.9 KII73975.1 - 0.62 9.9 7.4 0.21 11.4 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) ECF_trnsprt PF12822.7 KII73975.1 - 1.8 8.6 6.7 2.5 8.2 6.7 1.1 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Kelch_6 PF13964.6 KII73976.1 - 1.1e-21 76.3 19.4 2.4e-05 24.4 0.2 6.7 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KII73976.1 - 1e-17 63.8 12.6 0.0012 18.8 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 KII73976.1 - 4.1e-15 55.6 13.0 2e-05 24.7 0.0 7.1 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73976.1 - 1e-06 28.2 25.3 0.082 12.5 0.1 7.5 7 2 0 7 7 7 4 Kelch motif Kelch_2 PF07646.15 KII73976.1 - 7e-05 22.6 16.0 0.018 15.0 0.2 6.0 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 KII73976.1 - 0.0012 18.8 14.4 0.12 12.4 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 KII73977.1 - 0.0021 18.3 0.7 6.2 7.3 0.0 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII73977.1 - 0.04 13.9 0.2 2.7 8.1 0.1 2.7 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_3 PF13415.6 KII73977.1 - 0.051 13.9 0.3 0.57 10.5 0.0 2.4 2 1 0 2 2 2 0 Galactose oxidase, central domain Kelch_4 PF13418.6 KII73978.1 - 0.00049 20.1 1.1 0.0063 16.5 0.1 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73978.1 - 0.005 16.4 1.5 0.019 14.5 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 KII73978.1 - 0.034 14.4 0.6 1.3 9.4 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 KII73978.1 - 0.072 13.1 0.7 13 5.9 0.2 2.6 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 KII73978.1 - 0.076 13.3 0.0 2.8 8.3 0.0 2.4 2 1 0 2 2 2 0 Galactose oxidase, central domain Homeodomain PF00046.29 KII73979.1 - 2.5e-18 65.7 4.2 2.5e-18 65.7 4.2 1.8 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KII73979.1 - 0.0029 17.5 0.3 0.0067 16.3 0.3 1.7 1 0 0 1 1 1 1 Homeobox KN domain Kelch_6 PF13964.6 KII73980.1 - 8.1e-15 54.5 18.1 5.4e-06 26.5 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII73980.1 - 2.7e-09 37.1 14.9 0.037 14.3 0.1 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.6 KII73980.1 - 9.7e-07 28.7 22.1 0.28 11.2 0.3 6.4 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KII73980.1 - 0.0034 17.3 4.0 0.1 12.6 0.2 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 KII73980.1 - 0.0055 16.6 12.0 0.046 13.7 0.2 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 KII73980.1 - 0.0057 16.2 24.7 0.1 12.2 0.2 6.5 7 0 0 7 7 7 3 Kelch motif Kelch_6 PF13964.6 KII73981.1 - 1.7e-14 53.5 5.7 0.0056 16.9 0.1 4.4 4 1 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 KII73981.1 - 2e-09 37.3 10.8 0.047 13.7 0.1 5.1 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KII73981.1 - 1.6e-07 31.4 1.8 0.066 13.5 0.0 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII73981.1 - 0.0041 17.0 2.2 0.097 12.7 0.0 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 KII73981.1 - 0.036 13.6 13.3 9.7 5.9 0.1 5.6 5 2 0 5 5 5 0 Kelch motif Kelch_6 PF13964.6 KII73982.1 - 4.1e-14 52.3 10.4 0.004 17.4 0.1 6.7 7 0 0 7 7 7 4 Kelch motif Kelch_4 PF13418.6 KII73982.1 - 9e-12 44.8 6.4 0.046 13.7 0.0 5.9 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KII73982.1 - 1.1e-11 44.7 2.1 0.046 14.0 0.0 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII73982.1 - 1.6e-10 40.4 11.5 0.00014 21.4 0.3 6.2 5 1 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 KII73982.1 - 1.4e-06 28.1 7.1 0.14 12.2 0.3 6.0 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 KII73982.1 - 0.01 15.8 6.3 0.062 13.3 0.0 4.6 6 0 0 6 6 6 0 Kelch motif RolB_RolC PF02027.17 KII73982.1 - 0.13 11.9 0.0 0.37 10.4 0.0 1.6 2 0 0 2 2 2 0 RolB/RolC glucosidase family gag-asp_proteas PF13975.6 KII73983.1 - 0.00013 22.5 0.0 0.00031 21.3 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII73983.1 - 0.00042 20.9 0.0 0.0011 19.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII73983.1 - 0.0012 18.9 2.1 0.0012 18.9 2.1 2.8 5 0 0 5 5 5 1 Zinc knuckle Asp_protease PF09668.10 KII73983.1 - 0.013 15.2 0.1 0.049 13.4 0.1 1.9 1 1 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII73983.1 - 0.074 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease rve PF00665.26 KII73984.1 - 1e-07 32.2 0.0 1.5e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 KII73985.1 - 8.6e-28 96.7 0.0 1.3e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII73985.1 - 2.7e-22 78.7 0.0 5.3e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF150 PF02576.17 KII73987.1 - 0.04 14.3 0.1 0.069 13.6 0.1 1.3 1 0 0 1 1 1 0 RimP N-terminal domain LXG PF04740.12 KII73987.1 - 0.041 13.6 2.1 0.38 10.4 0.3 2.2 2 0 0 2 2 2 0 LXG domain of WXG superfamily ING PF12998.7 KII73987.1 - 0.057 14.0 1.5 6.3 7.5 0.2 2.4 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF5384 PF17358.2 KII73987.1 - 0.11 12.5 0.2 0.18 11.9 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5384) Col_cuticle_N PF01484.17 KII73987.1 - 0.15 12.2 0.2 0.46 10.6 0.2 1.8 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain RVT_1 PF00078.27 KII73988.1 - 0.013 15.0 0.1 0.017 14.7 0.1 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Integrin_beta PF00362.18 KII73989.1 - 0.00098 18.8 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI PF01437.25 KII73989.1 - 0.051 14.1 0.2 0.092 13.3 0.2 1.3 1 0 0 1 1 1 0 Plexin repeat EGF_2 PF07974.13 KII73990.1 - 3.6e-08 33.6 44.3 0.00022 21.5 13.6 3.7 3 1 0 3 3 3 2 EGF-like domain I-EGF_1 PF18372.1 KII73990.1 - 3.6e-05 23.7 10.6 3.6e-05 23.7 10.6 4.3 5 1 0 5 5 5 1 Integrin beta epidermal growth factor like domain 1 Methyltransf_28 PF02636.17 KII73992.1 - 0.027 14.1 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Glycos_transf_2 PF00535.26 KII73994.1 - 0.0078 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 GTP_EFTU PF00009.27 KII73996.1 - 3.5e-62 209.4 0.0 4.9e-62 208.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KII73996.1 - 3.7e-29 101.0 0.0 1.2e-28 99.3 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 KII73996.1 - 5.1e-19 68.1 0.0 1.6e-18 66.5 0.0 1.9 1 1 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KII73996.1 - 2.5e-13 49.9 0.0 5.9e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 KII73996.1 - 6e-08 33.0 0.0 2e-07 31.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 DUF4347 PF14252.6 KII73996.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4347) Bac_rhamnosid6H PF17389.2 KII73996.1 - 0.079 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain MBOAT PF03062.19 KII73997.1 - 9.5e-19 67.9 16.8 1.2e-18 67.6 16.8 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 KII73997.1 - 9.6e-06 25.8 7.0 1.9e-05 24.9 7.0 1.4 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family CNOT1_CAF1_bind PF16415.5 KII73997.1 - 0.012 15.0 0.2 0.017 14.5 0.2 1.2 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Mitofilin PF09731.9 KII73998.1 - 8e-09 34.9 14.1 8e-09 34.9 14.1 2.7 2 1 0 2 2 2 1 Mitochondrial inner membrane protein DUF4547 PF15080.6 KII73998.1 - 0.17 11.5 6.2 0.13 11.9 1.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4547) ApoLp-III PF07464.11 KII73998.1 - 0.27 11.3 13.5 0.15 12.1 2.8 3.5 2 2 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) GAT PF03127.14 KII73998.1 - 0.45 10.9 0.1 0.45 10.9 0.1 4.7 4 1 1 5 5 5 0 GAT domain MitMem_reg PF13012.6 KII73998.1 - 1.3 9.5 11.7 4 7.9 1.6 3.7 2 2 1 3 3 3 0 Maintenance of mitochondrial structure and function Lip_prot_lig_C PF10437.9 KII73998.1 - 7.5 6.6 9.0 1.1 9.3 2.4 3.1 3 0 0 3 3 3 0 Bacterial lipoate protein ligase C-terminus RRM_1 PF00076.22 KII73999.1 - 1.9e-14 53.2 0.0 3.3e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KII73999.1 - 0.0013 18.8 0.0 0.002 18.1 0.0 1.3 1 0 0 1 1 1 1 RNA binding motif RRM_7 PF16367.5 KII73999.1 - 0.008 16.3 0.1 0.046 13.8 0.1 2.1 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 KII73999.1 - 0.0095 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RabGAP-TBC PF00566.18 KII74002.1 - 7.5e-09 35.6 2.1 7.6e-07 29.0 2.1 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain zf-RanBP PF00641.18 KII74003.1 - 7.2e-07 28.4 5.7 9.6e-07 28.0 5.7 1.2 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Ribosomal_L21e PF01157.18 KII74005.1 - 4.6e-41 138.8 10.0 4.6e-41 138.8 10.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e MscS_porin PF12795.7 KII74006.1 - 2.8 7.4 12.7 0.024 14.2 2.4 2.4 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain Peptidase_C1 PF00112.23 KII74007.1 - 4.2e-35 121.8 0.7 4.9e-35 121.6 0.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Hemocyanin_M PF00372.19 KII74007.1 - 0.0072 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Hemocyanin, copper containing domain Peptidase_C1 PF00112.23 KII74008.1 - 2.6e-38 132.3 2.4 3.3e-38 132.0 2.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease FAM60A PF15396.6 KII74009.1 - 4.5e-06 26.8 0.3 8.9e-06 25.8 0.0 1.6 1 1 1 2 2 2 1 Protein Family FAM60A AT_hook PF02178.19 KII74009.1 - 0.37 10.8 6.5 0.085 12.8 3.1 1.8 2 0 0 2 2 2 0 AT hook motif Mo25 PF08569.11 KII74011.1 - 4e-35 121.8 0.1 5e-35 121.4 0.1 1.0 1 0 0 1 1 1 1 Mo25-like Flagellin_N PF00669.20 KII74011.1 - 0.03 14.4 1.0 0.043 13.9 1.0 1.2 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region Clathrin_lg_ch PF01086.17 KII74011.1 - 0.047 13.8 0.0 0.065 13.3 0.0 1.1 1 0 0 1 1 1 0 Clathrin light chain AF-4 PF05110.13 KII74018.1 - 0.063 11.4 11.6 0.077 11.1 11.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Presenilin PF01080.17 KII74018.1 - 0.16 10.7 2.5 0.18 10.6 2.5 1.2 1 0 0 1 1 1 0 Presenilin Frataxin_Cyay PF01491.16 KII74019.1 - 0.2 11.7 0.5 0.3 11.2 0.5 1.4 1 1 0 1 1 1 0 Frataxin-like domain Aminotran_1_2 PF00155.21 KII74020.1 - 3.8e-14 52.6 0.0 4.2e-14 52.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Poly_export PF02563.16 KII74020.1 - 0.14 12.4 0.0 0.47 10.7 0.0 1.9 2 1 1 3 3 3 0 Polysaccharide biosynthesis/export protein Aminotran_1_2 PF00155.21 KII74022.1 - 9.5e-25 87.5 0.0 1.5e-24 86.9 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II DUF21 PF01595.20 KII74023.1 - 8.1e-30 103.8 9.5 1.1e-29 103.4 9.5 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain RE_Alw26IDE PF09665.10 KII74023.1 - 0.11 11.6 0.1 0.16 11.1 0.1 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) RT_RNaseH_2 PF17919.1 KII74024.1 - 1.1e-34 118.4 0.1 2.8e-34 117.1 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74024.1 - 4e-24 84.9 0.0 9.8e-24 83.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74024.1 - 2.1e-19 70.0 0.0 4.7e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII74024.1 - 3.6e-07 30.6 0.0 7.4e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII74024.1 - 1.7e-05 25.4 0.0 4.2e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII74024.1 - 0.0028 17.9 0.1 0.007 16.7 0.1 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII74024.1 - 0.037 13.8 0.0 0.098 12.4 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_5 PF14787.6 KII74024.1 - 0.097 12.4 3.7 0.27 11.0 3.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Pkinase PF00069.25 KII74027.1 - 1.8e-61 207.9 0.1 2.3e-61 207.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII74027.1 - 5.7e-30 104.5 0.1 9e-30 103.8 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KII74027.1 - 6.7e-05 22.3 0.2 0.00011 21.6 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KII74027.1 - 0.00019 20.5 0.2 0.00024 20.1 0.2 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KII74027.1 - 0.00026 20.4 0.1 0.0004 19.8 0.1 1.3 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KII74027.1 - 0.0033 17.4 0.1 0.0039 17.1 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KII74027.1 - 0.014 14.5 0.2 0.022 13.8 0.2 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 KII74027.1 - 0.017 13.9 0.1 0.021 13.6 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 KII74027.1 - 0.026 14.1 0.3 0.037 13.6 0.3 1.2 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 KII74027.1 - 0.13 11.9 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 ORC4_C PF14629.6 KII74028.1 - 0.015 14.7 1.5 0.024 14.0 1.5 1.4 1 1 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus RF-1 PF00472.20 KII74030.1 - 1.7e-05 24.7 0.1 3.5e-05 23.7 0.1 1.6 1 1 0 1 1 1 1 RF-1 domain DUF3906 PF13046.6 KII74030.1 - 0.07 13.2 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) MULE PF10551.9 KII74031.1 - 1.6e-15 57.3 0.4 3.5e-15 56.2 0.2 1.7 2 0 0 2 2 2 1 MULE transposase domain HU-CCDC81_euk_1 PF14908.6 KII74031.1 - 0.11 12.6 0.1 0.31 11.2 0.1 1.7 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 DUF2423 PF10338.9 KII74032.1 - 0.0049 17.1 6.2 0.0049 17.1 6.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) DDE_Tnp_IS1595 PF12762.7 KII74033.1 - 0.00011 22.2 0.0 0.00017 21.6 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DUF1667 PF07892.11 KII74035.1 - 0.012 15.6 0.2 0.023 14.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1667) DUF4685 PF15737.5 KII74037.1 - 0.0063 17.0 0.1 0.0087 16.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4685) ScsC_N PF18312.1 KII74037.1 - 0.21 11.4 9.4 4.1 7.3 0.0 3.9 4 1 0 4 4 4 0 Copper resistance protein ScsC N-terminal domain DUF2040 PF09745.9 KII74038.1 - 1.4e-26 92.9 11.5 2e-26 92.4 11.5 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 55 (DUF2040) WD40 PF00400.32 KII74039.1 - 6.3e-05 23.7 0.1 0.12 13.3 0.0 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat zf-RING_14 PF17978.1 KII74039.1 - 0.02 15.3 2.5 0.051 14.0 1.6 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain RBD-FIP PF09457.10 KII74040.1 - 2.9e-05 23.9 1.9 4.3e-05 23.3 1.9 1.3 1 0 0 1 1 1 1 FIP domain DUF2408 PF10303.9 KII74041.1 - 0.05 14.2 0.1 0.083 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) BAR PF03114.18 KII74042.1 - 3.9e-10 39.8 0.0 5.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 KII74042.1 - 0.0055 15.9 0.1 0.007 15.5 0.1 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF4349 PF14257.6 KII74042.1 - 0.042 13.3 0.1 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) SesA PF17107.5 KII74042.1 - 0.12 12.5 0.4 0.9 9.7 0.2 2.2 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ATP_bind_3 PF01171.20 KII74043.1 - 0.00016 21.5 0.0 0.00029 20.6 0.0 1.4 1 0 0 1 1 1 1 PP-loop family PAPS_reduct PF01507.19 KII74043.1 - 0.0029 17.7 0.0 0.0049 16.9 0.0 1.5 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Gln-synt_C-ter PF18318.1 KII74043.1 - 0.046 13.6 0.2 8.8 6.2 0.1 3.3 3 1 1 4 4 4 0 Glutamine synthetase C-terminal domain ESSS PF10183.9 KII74044.1 - 0.098 12.9 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) FixQ PF05545.11 KII74044.1 - 0.11 12.4 0.1 0.11 12.4 0.1 1.8 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ CCB1 PF12046.8 KII74044.1 - 0.16 11.3 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B DUF485 PF04341.12 KII74044.1 - 1.6 8.7 5.2 4.3 7.4 5.2 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF485 RPEL PF02755.15 KII74045.1 - 0.00079 19.0 0.2 0.0056 16.3 0.2 2.2 2 0 0 2 2 2 1 RPEL repeat DDE_Tnp_IS1595 PF12762.7 KII74046.1 - 0.00085 19.4 0.2 0.002 18.1 0.2 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain S1 PF00575.23 KII74047.1 - 1.1e-23 83.4 10.1 5.9e-07 29.7 0.0 6.8 9 0 0 9 9 9 4 S1 RNA binding domain PCB_OB PF17092.5 KII74047.1 - 4.3e-05 24.2 0.0 3.2 8.5 0.0 4.0 4 0 0 4 4 4 2 Penicillin-binding protein OB-like domain TPR_14 PF13428.6 KII74047.1 - 0.014 16.1 0.0 26 6.0 0.2 3.6 2 2 1 3 3 3 0 Tetratricopeptide repeat NRDE-2 PF08424.10 KII74047.1 - 0.041 13.0 0.2 0.47 9.5 0.1 2.2 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference TPR_19 PF14559.6 KII74047.1 - 0.09 13.3 0.0 5.4 7.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Suf PF05843.14 KII74047.1 - 0.77 9.7 6.2 11 6.0 2.3 2.3 1 1 0 2 2 2 0 Suppressor of forked protein (Suf) ubiquitin PF00240.23 KII74048.1 - 4.9e-67 221.6 4.6 8.7e-33 111.9 0.4 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 KII74048.1 - 1.6e-33 114.4 4.9 5.3e-16 58.2 0.4 2.3 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KII74048.1 - 8.5e-11 42.2 0.7 0.0011 19.3 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KII74048.1 - 6.5e-08 32.7 0.3 0.021 14.9 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 KII74048.1 - 1.2e-07 32.0 0.2 0.021 15.2 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 KII74048.1 - 2.2e-07 30.7 0.2 0.026 14.5 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 KII74048.1 - 5.4e-05 23.7 0.1 0.51 10.9 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 KII74048.1 - 0.0005 19.9 0.1 0.81 9.5 0.0 2.1 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 KII74048.1 - 0.0011 19.0 6.5 13 5.9 0.0 4.1 4 0 0 4 4 4 2 Ubiquitin-like domain PI3K_rbd PF00794.18 KII74048.1 - 0.008 16.3 0.8 4.8 7.4 0.1 2.6 2 1 0 2 2 2 2 PI3-kinase family, ras-binding domain eRF1_1 PF03463.15 KII74048.1 - 0.012 15.6 0.2 4.3 7.4 0.0 2.5 1 1 1 2 2 2 0 eRF1 domain 1 DUF2870 PF11069.8 KII74048.1 - 0.022 15.1 0.0 13 6.3 0.0 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF2870) UDP-g_GGTase PF06427.11 KII74048.1 - 0.15 12.2 0.4 2 8.6 0.0 2.5 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase ubiquitin PF00240.23 KII74049.1 - 4.3e-169 548.6 28.7 3.5e-32 110.0 0.4 6.0 6 0 0 6 6 6 6 Ubiquitin family Rad60-SLD PF11976.8 KII74049.1 - 2.5e-82 270.7 28.8 1.2e-15 57.1 0.7 6.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KII74049.1 - 3.4e-25 88.3 10.0 0.0031 17.9 0.1 6.9 5 5 0 5 5 5 5 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KII74049.1 - 1e-18 67.5 4.6 0.079 13.1 0.0 6.1 5 4 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 KII74049.1 - 1.6e-18 66.4 3.6 0.09 12.7 0.0 5.3 5 0 0 5 5 5 5 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 KII74049.1 - 2.2e-18 66.4 8.3 0.036 14.4 0.1 5.2 5 0 0 5 5 5 5 Ubiquitin-like domain DUF2407 PF10302.9 KII74049.1 - 7.3e-13 49.0 2.5 1.7 9.3 0.0 5.2 1 1 1 5 5 5 5 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 KII74049.1 - 1.8e-09 37.7 0.5 4 7.2 0.0 5.2 1 1 4 5 5 5 4 Silencing defective 2 N-terminal ubiquitin domain UDP-g_GGTase PF06427.11 KII74049.1 - 1e-08 35.3 7.7 5.2 7.2 0.0 5.6 6 0 0 6 6 6 5 UDP-glucose:Glycoprotein Glucosyltransferase PI3K_rbd PF00794.18 KII74049.1 - 1.7e-08 34.6 5.4 14 5.9 0.0 6.4 6 0 0 6 6 6 0 PI3-kinase family, ras-binding domain eRF1_1 PF03463.15 KII74049.1 - 6.3e-08 32.7 7.6 7.6 6.5 0.0 6.3 6 0 0 6 6 6 1 eRF1 domain 1 DUF2870 PF11069.8 KII74049.1 - 5.8e-07 29.8 0.0 44 4.5 0.0 5.7 5 0 0 5 5 5 0 Protein of unknown function (DUF2870) TOBE_2 PF08402.10 KII74049.1 - 1.9e-06 27.9 0.3 50 4.2 0.0 5.5 6 0 0 6 6 5 0 TOBE domain DUF969 PF06149.12 KII74049.1 - 1.1e-05 25.0 0.1 38 3.6 0.0 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF969) ORF11CD3 PF10549.9 KII74049.1 - 7.3e-05 22.8 0.0 85 3.4 0.0 5.6 5 0 0 5 5 5 0 ORF11CD3 domain Ubiquitin_4 PF18036.1 KII74049.1 - 0.0012 18.9 30.5 38 4.4 0.0 10.0 11 0 0 11 11 11 0 Ubiquitin-like domain CorA PF01544.18 KII74049.1 - 0.0078 15.6 0.8 1.2e+02 1.8 0.0 4.7 5 0 0 5 5 5 0 CorA-like Mg2+ transporter protein Myosin_N PF02736.19 KII74049.1 - 0.094 12.6 15.2 90 3.0 0.1 7.3 6 0 0 6 6 6 0 Myosin N-terminal SH3-like domain ProRS-C_2 PF09181.10 KII74049.1 - 0.18 12.0 4.3 2.4e+02 1.9 0.0 4.7 5 0 0 5 5 5 0 Prolyl-tRNA synthetase, C-terminal LBP_C PF17386.2 KII74049.1 - 0.35 10.8 3.4 4.3e+02 0.9 0.0 5.1 6 0 0 6 6 6 0 Lacto-N-biose phosphorylase C-terminal domain YcgR_2 PF12945.7 KII74049.1 - 0.96 9.6 6.2 2.8e+02 1.7 0.0 4.9 5 0 0 5 5 5 0 Flagellar protein YcgR FlgD_ig PF13860.6 KII74049.1 - 9.5 6.2 10.9 1.8e+02 2.1 0.1 5.0 5 0 0 5 5 5 0 FlgD Ig-like domain Mt_ATP-synt_D PF05873.12 KII74050.1 - 1.8e-06 27.9 0.4 2.5e-06 27.4 0.4 1.5 1 1 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) BACK PF07707.15 KII74050.1 - 0.14 12.2 0.2 0.44 10.7 0.1 1.7 1 1 1 2 2 2 0 BTB And C-terminal Kelch HTH_23 PF13384.6 KII74051.1 - 2.4e-05 24.0 0.0 4.4e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 KII74051.1 - 6.1e-05 23.1 0.0 0.00013 22.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 KII74051.1 - 8e-05 22.6 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.6 KII74051.1 - 0.0014 18.4 0.0 0.044 13.6 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII74051.1 - 0.003 17.5 0.1 0.0037 17.2 0.1 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.16 KII74051.1 - 0.04 14.0 0.2 0.057 13.5 0.2 1.2 1 0 0 1 1 1 0 Transposase ICEA PF05315.11 KII74051.1 - 0.04 13.4 0.2 0.052 13.0 0.2 1.2 1 0 0 1 1 1 0 ICEA Protein HTH_11 PF08279.12 KII74051.1 - 0.062 13.3 0.2 0.12 12.4 0.2 1.5 1 0 0 1 1 1 0 HTH domain HTH_Crp_2 PF13545.6 KII74051.1 - 0.16 12.0 0.1 0.38 10.8 0.0 1.6 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain TK PF00265.18 KII74052.1 - 1.5e-29 103.1 0.1 1.8e-29 102.9 0.1 1.0 1 0 0 1 1 1 1 Thymidine kinase Motilin_ghrelin PF04644.12 KII74055.1 - 0.11 12.3 0.7 0.23 11.3 0.7 1.5 1 0 0 1 1 1 0 Motilin/ghrelin Mito_carr PF00153.27 KII74057.1 - 8.1e-21 73.8 0.0 8.8e-21 73.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein CTD_bind PF04818.13 KII74059.1 - 1.6e-06 28.8 0.1 1.6e-05 25.6 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase II-binding domain. AKAP7_NLS PF10469.9 KII74059.1 - 0.011 15.6 1.1 0.013 15.4 0.1 1.5 2 0 0 2 2 2 0 AKAP7 2'5' RNA ligase-like domain DUF1985 PF09331.11 KII74059.1 - 0.055 13.5 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1985) WD40 PF00400.32 KII74060.1 - 1.9e-07 31.6 10.0 0.088 13.7 0.0 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 KII74060.1 - 3.6e-06 26.5 0.0 9.3e-06 25.2 0.0 1.6 2 0 0 2 2 2 1 WD40-like domain CPSF_A PF03178.15 KII74060.1 - 0.0023 17.3 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 CPSF A subunit region Fer4_3 PF12798.7 KII74060.1 - 0.85 10.7 4.9 2.4 9.3 4.9 1.8 1 0 0 1 1 1 0 4Fe-4S binding domain NLE PF08154.12 KII74061.1 - 0.00026 21.5 0.0 0.0004 20.9 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 KII74061.1 - 0.017 16.0 1.3 0.08 13.8 0.2 2.2 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF4625 PF15418.6 KII74061.1 - 0.035 14.3 0.3 0.048 13.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) FliS_cochap PF16522.5 KII74063.1 - 0.014 15.3 0.2 0.016 15.1 0.2 1.2 1 0 0 1 1 1 0 Flagellar FLiS export co-chaperone, HP1076 eIF-1a PF01176.19 KII74063.1 - 0.029 14.2 0.0 0.069 13.0 0.0 1.6 1 1 0 1 1 1 0 Translation initiation factor 1A / IF-1 Ldl_recept_a PF00057.18 KII74064.1 - 1.3e-26 92.5 60.7 9.4e-10 38.6 14.8 4.3 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.18 KII74065.1 - 5.1e-09 36.2 21.2 4.5e-05 23.6 8.5 2.6 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Kinesin PF00225.23 KII74066.1 - 2e-22 79.6 0.0 2.3e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KII74066.1 - 7.7e-15 55.1 0.0 9.9e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 Microtubule binding PIF1 PF05970.14 KII74066.1 - 0.031 13.5 0.1 0.044 13.0 0.1 1.1 1 0 0 1 1 1 0 PIF1-like helicase Rep_fac-A_3 PF08661.11 KII74066.1 - 0.033 14.5 0.1 0.044 14.1 0.1 1.2 1 0 0 1 1 1 0 Replication factor A protein 3 Kinesin PF00225.23 KII74067.1 - 1.7e-51 175.1 0.0 2e-51 174.9 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain CC2-LZ PF16516.5 KII74068.1 - 0.0094 16.3 11.9 0.0094 16.3 11.9 2.9 1 1 2 3 3 3 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ADIP PF11559.8 KII74068.1 - 0.17 11.9 26.3 0.25 11.4 16.8 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Csm1_N PF18504.1 KII74068.1 - 0.46 10.9 16.4 1.4 9.4 3.1 3.3 2 2 0 2 2 2 0 Csm1 N-terminal domain TSC22 PF01166.18 KII74068.1 - 1.4 9.3 16.0 7.3 7.0 1.7 4.0 2 2 2 4 4 4 0 TSC-22/dip/bun family HIP1_clath_bdg PF16515.5 KII74068.1 - 4.5 7.9 18.9 14 6.4 2.7 2.7 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fez1 PF06818.15 KII74068.1 - 5.3 7.5 22.0 0.75 10.2 12.8 2.1 1 1 1 2 2 2 0 Fez1 CENP-H PF05837.12 KII74068.1 - 5.8 7.4 21.2 15 6.1 13.2 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Pox_polyA_pol_C PF12629.7 KII74069.1 - 0.025 14.4 0.1 0.031 14.1 0.1 1.1 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain LAG1-DNAbind PF09271.11 KII74073.1 - 2.1e-05 25.2 1.3 0.0086 16.7 0.2 3.2 2 1 1 3 3 3 2 LAG1, DNA binding BTD PF09270.10 KII74073.1 - 0.031 14.5 0.0 0.07 13.4 0.0 1.7 1 1 1 2 2 2 0 Beta-trefoil DNA-binding domain ITAM_Cys-rich PF10538.9 KII74075.1 - 0.12 12.1 0.7 0.12 12.1 0.7 1.8 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif Mad3_BUB1_I PF08311.12 KII74078.1 - 7.2e-22 77.7 1.4 1.2e-21 76.9 1.4 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 MMR_HSR1 PF01926.23 KII74079.1 - 2.1e-14 53.6 0.0 3.6e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KII74079.1 - 7.5e-05 22.3 0.4 0.0002 20.9 0.1 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KII74079.1 - 0.00081 19.3 0.0 0.0048 16.8 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase 120_Rick_ant PF12574.8 KII74079.1 - 0.013 14.7 0.1 0.021 14.1 0.1 1.2 1 0 0 1 1 1 0 120 KDa Rickettsia surface antigen Dynamin_N PF00350.23 KII74079.1 - 0.033 14.3 0.3 0.033 14.3 0.3 2.7 2 1 1 3 3 3 0 Dynamin family AAA_18 PF13238.6 KII74079.1 - 0.12 12.9 0.1 4 8.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain Thioredoxin_6 PF13848.6 KII74080.1 - 1.4e-10 41.4 0.8 9.1e-07 29.0 0.1 4.2 3 1 1 4 4 4 3 Thioredoxin-like domain Thioredoxin PF00085.20 KII74080.1 - 1e-07 31.8 0.0 0.041 13.9 0.0 4.1 4 0 0 4 4 4 3 Thioredoxin PK PF00224.21 KII74081.1 - 3.6e-61 207.0 0.5 4.4e-61 206.7 0.5 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KII74081.1 - 3.5e-26 91.7 0.0 1e-25 90.2 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain RVT_1 PF00078.27 KII74083.1 - 9.9e-18 64.5 0.0 1.2e-17 64.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII74084.1 - 7.3e-19 67.7 0.0 1.3e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74084.1 - 5.8e-18 65.1 0.0 1.3e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII74084.1 - 2.2e-09 37.3 0.1 4e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII74084.1 - 1.6e-05 25.0 0.1 4e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Peptidase_A17 PF05380.13 KII74084.1 - 0.061 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Pao retrotransposon peptidase DDE_3 PF13358.6 KII74086.1 - 1.3e-15 57.5 0.0 1.4e-15 57.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease PK PF00224.21 KII74087.1 - 5.4e-126 420.2 9.4 6.7e-126 419.8 9.4 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KII74087.1 - 2.7e-27 95.3 0.2 5.1e-26 91.2 0.0 2.9 4 0 0 4 4 4 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KII74087.1 - 9e-07 28.3 0.6 2e-06 27.1 0.5 1.5 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family OKR_DC_1_C PF03711.15 KII74087.1 - 0.13 12.5 0.2 0.38 11.1 0.1 1.8 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, C-terminal domain zf-C2H2 PF00096.26 KII74088.1 - 0.0016 18.8 16.7 0.17 12.4 0.0 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII74088.1 - 0.0053 17.5 16.1 0.83 10.7 0.0 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KII74088.1 - 0.0093 15.7 0.0 0.0093 15.7 0.0 3.1 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2_9 PF16293.5 KII74088.1 - 0.048 13.5 0.1 0.15 12.0 0.1 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) zf-H2C2_2 PF13465.6 KII74088.1 - 1.8 9.1 23.8 0.22 12.0 3.3 3.4 2 1 1 3 3 3 0 Zinc-finger double domain Aldo_ket_red PF00248.21 KII74090.1 - 7.9e-09 35.1 0.0 9.6e-09 34.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KII74091.1 - 1.9e-31 109.4 0.0 2.3e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RVP_2 PF08284.11 KII74092.1 - 0.0059 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Mt_ATP-synt_B PF05405.14 KII74092.1 - 0.033 13.8 0.1 0.34 10.5 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Peptidase_A2E PF12382.8 KII74092.1 - 0.061 13.4 0.0 0.13 12.3 0.0 1.6 1 1 0 1 1 1 0 Retrotransposon peptidase DUF454 PF04304.13 KII74092.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF454) RT_RNaseH_2 PF17919.1 KII74095.1 - 5.1e-06 26.4 0.0 8.7e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase NLRC4_HD PF17889.1 KII74095.1 - 0.073 13.4 0.6 0.2 12.0 0.2 2.0 2 1 0 2 2 2 0 NLRC4 helical domain Retrotran_gag_2 PF14223.6 KII74098.1 - 0.031 13.9 0.1 3.2 7.4 0.1 2.3 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type B12-binding PF02310.19 KII74100.1 - 1.2e-12 47.9 0.1 1.5e-12 47.7 0.1 1.1 1 0 0 1 1 1 1 B12 binding domain IMPDH PF00478.25 KII74100.1 - 0.0089 15.1 0.0 0.011 14.8 0.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain MM_CoA_mutase PF01642.22 KII74101.1 - 1.3e-50 172.4 0.2 1.5e-50 172.3 0.2 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase DDE_3 PF13358.6 KII74102.1 - 0.0004 20.2 0.0 0.00055 19.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RT_RNaseH_2 PF17919.1 KII74104.1 - 0.011 15.8 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74106.1 - 5.6e-14 52.2 0.1 9.3e-14 51.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TolA PF06519.11 KII74106.1 - 0.087 13.0 0.1 9.6 6.5 0.0 2.8 2 0 0 2 2 2 0 TolA C-terminal DDE_3 PF13358.6 KII74107.1 - 1.9e-08 34.2 0.0 3.9e-08 33.2 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_Tnp_IS1595 PF12762.7 KII74108.1 - 0.0014 18.7 0.0 0.0017 18.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain FAS_I_H PF18314.1 KII74108.1 - 0.037 13.7 0.0 0.043 13.4 0.0 1.1 1 0 0 1 1 1 0 Fatty acid synthase type I helical domain RGCC PF15151.6 KII74112.1 - 0.097 12.9 1.1 0.22 11.7 1.0 1.7 1 1 0 1 1 1 0 Response gene to complement 32 protein family CPW_WPC PF09717.10 KII74113.1 - 0.48 11.5 4.1 4.6 8.3 0.6 2.5 3 0 0 3 3 3 0 Plasmodium falciparum domain of unknown function (CPW_WPC) zf-CCHC PF00098.23 KII74116.1 - 0.0045 17.0 1.0 0.0045 17.0 1.0 2.6 3 0 0 3 3 3 1 Zinc knuckle zf-C2H2_10 PF16588.5 KII74116.1 - 0.0055 16.4 1.5 0.0055 16.4 1.5 2.0 2 0 0 2 2 2 1 C2H2 zinc-finger FcoT PF10862.8 KII74116.1 - 0.11 12.0 0.4 11 5.5 0.0 2.2 1 1 1 2 2 2 0 FcoT-like thioesterase domain RVT_1 PF00078.27 KII74117.1 - 1.6e-23 83.4 0.0 2.5e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Nup96 PF12110.8 KII74117.1 - 0.2 10.8 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Nuclear protein 96 CxC5 PF18718.1 KII74121.1 - 3.5 7.7 6.7 1.2 9.2 1.9 2.1 2 0 0 2 2 2 0 CxC5 like cysteine cluster associated with KDZ transposases Fibrinogen_BP PF08017.11 KII74122.1 - 0.026 13.0 0.1 0.028 12.9 0.1 1.0 1 0 0 1 1 1 0 Fibrinogen binding protein AIG1 PF04548.16 KII74122.1 - 0.03 13.7 0.1 0.034 13.5 0.1 1.0 1 0 0 1 1 1 0 AIG1 family zf-C2H2_jaz PF12171.8 KII74125.1 - 8.8 6.8 8.1 2.5 8.5 0.3 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding SIX1_SD PF16878.5 KII74126.1 - 0.031 14.8 3.6 0.031 14.8 3.6 1.7 2 0 0 2 2 2 0 Transcriptional regulator, SIX1, N-terminal SD domain zf-C2H2_jaz PF12171.8 KII74127.1 - 0.13 12.5 1.7 20 5.6 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KII74127.1 - 1.5 9.5 5.5 14 6.4 1.0 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII74127.1 - 1.6 9.8 9.5 2.6 9.1 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KII74127.1 - 3.6 7.6 6.4 0.96 9.4 1.6 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type VCBS PF13517.6 KII74133.1 - 1.7e-07 31.7 0.6 2.2e-06 28.1 0.2 1.7 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KII74133.1 - 0.00013 22.0 1.5 0.39 10.9 0.0 2.4 2 0 0 2 2 2 2 FG-GAP repeat CENP-B_N PF04218.13 KII74134.1 - 3.4e-06 26.6 0.0 5.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain FLYWCH PF04500.16 KII74136.1 - 0.0027 17.8 4.4 0.0049 17.0 4.4 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain HIP1_clath_bdg PF16515.5 KII74138.1 - 0.018 15.7 0.4 0.021 15.4 0.4 1.1 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PriX PF18689.1 KII74138.1 - 0.02 15.2 1.2 0.029 14.7 0.7 1.5 1 1 1 2 2 2 0 Primase X Sortilin_C PF15901.5 KII74139.1 - 8.1e-06 26.3 0.4 1.1e-05 25.9 0.4 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal DDE_3 PF13358.6 KII74140.1 - 7.9e-15 54.9 0.1 1.2e-14 54.3 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF997 PF06196.12 KII74141.1 - 0.18 11.9 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF997) Ldl_recept_a PF00057.18 KII74142.1 - 3.5e-18 65.5 29.9 3.3e-12 46.4 10.4 3.0 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII74145.1 - 0.0034 17.7 0.0 0.0065 16.8 0.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal AvrM_N PF18247.1 KII74145.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain A_thal_3526 PF09713.10 KII74147.1 - 0.034 14.4 0.1 0.069 13.4 0.1 1.6 1 0 0 1 1 1 0 Plant protein 1589 of unknown function (A_thal_3526) hSac2 PF12456.8 KII74148.1 - 0.056 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Inositol phosphatase CC PF04942.14 KII74148.1 - 9.2 6.6 7.2 1.7 8.9 0.7 2.6 2 1 0 2 2 2 0 CC domain TUDOR PF00567.24 KII74149.1 - 3.9e-17 62.4 0.0 6.9e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 KII74149.1 - 3.8e-05 23.1 0.0 5.4e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) DUF4537 PF15057.6 KII74149.1 - 0.007 16.4 0.0 0.017 15.1 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4537) LRR_6 PF13516.6 KII74151.1 - 3.2e-08 33.0 15.4 0.02 14.9 0.0 6.1 5 1 1 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.7 KII74151.1 - 6.4e-05 23.2 16.6 0.014 15.8 2.6 4.1 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KII74151.1 - 7e-05 22.8 8.3 3.1 8.7 0.1 4.9 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_8 PF13855.6 KII74151.1 - 0.0073 16.0 14.8 0.22 11.3 3.0 4.4 2 2 1 3 3 3 1 Leucine rich repeat A1_Propeptide PF07966.12 KII74151.1 - 0.28 11.1 0.4 0.28 11.1 0.4 2.0 2 0 0 2 2 2 0 A1 Propeptide LRR_6 PF13516.6 KII74152.1 - 1.4e-05 24.8 2.0 1.5 9.1 0.0 3.6 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 KII74152.1 - 0.0022 18.4 0.1 0.43 11.1 0.0 2.8 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KII74152.1 - 0.0029 17.9 0.2 11 7.1 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich Repeat DUF5612 PF18462.1 KII74152.1 - 0.054 13.3 0.0 0.074 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5612) PSII_BNR PF14870.6 KII74152.1 - 0.063 12.5 0.2 0.084 12.1 0.2 1.1 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 Neurochondrin PF05536.11 KII74153.1 - 2.2e-06 26.3 0.1 4e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 Neurochondrin GTP_EFTU PF00009.27 KII74154.1 - 0.00024 20.7 0.2 0.00078 19.0 0.2 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KII74154.1 - 0.0016 18.8 0.1 0.0078 16.6 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu domain 2 AAA_16 PF13191.6 KII74154.1 - 0.0042 17.5 0.0 0.0094 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DLIC PF05783.11 KII74154.1 - 0.094 11.5 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) DUF2482 PF10655.9 KII74154.1 - 0.14 12.6 0.5 5.7 7.5 0.1 2.7 2 0 0 2 2 2 0 Hypothetical protein of unknown function (DUF2482) rve PF00665.26 KII74158.1 - 7e-24 84.3 0.0 1.1e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74158.1 - 3.3e-09 36.7 1.4 7.1e-09 35.6 1.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII74158.1 - 8.6e-06 25.4 0.0 1.5e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII74158.1 - 0.00084 19.5 0.3 0.0014 18.8 0.3 1.4 1 0 0 1 1 1 1 H2C2 zinc finger RT_RNaseH_2 PF17919.1 KII74159.1 - 6.9e-32 109.5 0.0 1.7e-31 108.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74159.1 - 1.3e-30 105.7 0.0 4.5e-30 104.0 0.0 2.0 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74159.1 - 4.7e-26 91.7 0.1 3.4e-25 88.9 0.0 2.5 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII74159.1 - 2.4e-20 72.9 0.0 8.6e-20 71.1 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74159.1 - 1.2e-12 47.7 11.5 5.2e-12 45.7 0.2 2.7 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII74159.1 - 0.00057 19.6 0.4 0.0031 17.3 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain Asp_protease PF09668.10 KII74159.1 - 0.0045 16.8 0.7 0.01 15.6 0.7 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII74159.1 - 0.0061 16.9 0.5 0.037 14.3 0.1 2.5 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII74159.1 - 0.015 15.9 0.0 0.037 14.6 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII74159.1 - 0.068 13.8 0.0 0.15 12.8 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease zf-H2C2 PF09337.10 KII74159.1 - 0.52 10.6 5.2 0.69 10.2 0.2 2.9 2 0 0 2 2 2 0 H2C2 zinc finger HNH_4 PF13395.6 KII74160.1 - 0.021 14.7 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 HNH endonuclease DDE_Tnp_IS1595 PF12762.7 KII74161.1 - 4.1e-11 43.1 0.0 5.7e-11 42.7 0.0 1.3 1 1 0 1 1 1 1 ISXO2-like transposase domain Mdv1 PF11542.8 KII74162.1 - 0.026 14.5 0.1 0.04 13.9 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial division protein 1 RAG1 PF12940.7 KII74166.1 - 0.12 10.5 0.2 0.13 10.3 0.2 1.1 1 0 0 1 1 1 0 Recombination-activation protein 1 (RAG1), recombinase GIT_CC PF16559.5 KII74167.1 - 0.023 14.5 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor RhoGAP PF00620.27 KII74168.1 - 1.5e-34 119.0 0.2 3e-34 118.0 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain DUF3426 PF11906.8 KII74169.1 - 0.02 15.1 0.0 0.033 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3426) Guanylate_cyc PF00211.20 KII74170.1 - 1.1e-47 162.0 0.3 1.8e-47 161.3 0.3 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3853 PF12964.7 KII74170.1 - 0.0046 17.1 0.1 2.5 8.3 0.0 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3853) Pkinase_Tyr PF07714.17 KII74170.1 - 0.017 14.4 0.1 0.034 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase Archease PF01951.16 KII74170.1 - 0.034 14.4 0.2 0.17 12.1 0.1 2.0 2 0 0 2 2 2 0 Archease protein family (MTH1598/TM1083) HNOBA PF07701.14 KII74170.1 - 0.037 13.4 1.3 0.064 12.7 0.9 1.6 2 0 0 2 2 2 0 Heme NO binding associated RNase_3_N PF18497.1 KII74170.1 - 0.06 13.6 0.7 0.16 12.2 0.3 1.9 1 1 1 2 2 2 0 Ribonuclease III N-terminal domain FliP PF00813.20 KII74170.1 - 0.092 12.6 0.3 0.15 11.9 0.3 1.3 1 0 0 1 1 1 0 FliP family Gelsolin PF00626.22 KII74171.1 - 3.3e-24 84.6 1.3 5.7e-06 26.1 0.0 4.6 4 0 0 4 4 4 4 Gelsolin repeat LRR_8 PF13855.6 KII74172.1 - 9.2e-31 105.4 34.5 1.4e-11 44.0 1.5 8.4 4 3 7 11 11 11 8 Leucine rich repeat LRR_4 PF12799.7 KII74172.1 - 1.7e-25 88.6 37.4 3.9e-07 30.3 1.0 10.0 8 2 4 12 12 12 8 Leucine Rich repeats (2 copies) Gelsolin PF00626.22 KII74172.1 - 2.7e-18 65.6 0.0 2.5e-12 46.5 0.0 2.6 2 0 0 2 2 2 2 Gelsolin repeat LRR_1 PF00560.33 KII74172.1 - 0.00081 19.6 29.1 23 6.1 0.1 11.7 8 4 1 9 9 9 0 Leucine Rich Repeat LRR_9 PF14580.6 KII74172.1 - 0.0013 18.3 17.1 0.0039 16.7 0.2 4.6 2 1 1 5 5 5 3 Leucine-rich repeat KRTDAP PF15200.6 KII74172.1 - 0.022 14.5 0.2 0.14 11.9 0.0 2.4 2 0 0 2 2 2 0 Keratinocyte differentiation-associated DUF3557 PF12078.8 KII74172.1 - 0.91 9.5 5.3 1.7 8.6 1.3 3.3 1 1 1 3 3 3 0 Domain of unknown function (DUF3557) LRR_6 PF13516.6 KII74172.1 - 3.1 8.1 36.7 3.7 7.9 0.1 10.2 12 0 0 12 12 12 0 Leucine Rich repeat SNF2_N PF00176.23 KII74173.1 - 4.1e-69 233.0 1.2 4.1e-69 233.0 1.2 2.3 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KII74173.1 - 7.9e-21 74.5 0.0 1.5e-19 70.4 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 KII74173.1 - 4.9e-20 71.4 0.6 1.9e-18 66.3 0.1 2.8 2 0 0 2 2 2 1 Bromodomain ResIII PF04851.15 KII74173.1 - 1.1e-08 35.3 2.2 4.3e-08 33.4 0.0 3.1 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit HSA PF07529.13 KII74173.1 - 1.8e-06 28.1 9.4 6.9e-06 26.3 9.4 2.1 1 0 0 1 1 1 1 HSA DEAD PF00270.29 KII74173.1 - 8.1e-05 22.5 0.1 0.00055 19.7 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase SnAC PF14619.6 KII74173.1 - 0.0087 16.6 0.4 0.0087 16.6 0.4 3.0 2 0 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex DBINO PF13892.6 KII74173.1 - 0.022 15.1 6.9 0.062 13.7 6.9 1.7 1 0 0 1 1 1 0 DNA-binding domain HxlR PF01638.17 KII74173.1 - 0.1 12.5 0.4 8.2 6.4 0.1 3.2 2 0 0 2 2 2 0 HxlR-like helix-turn-helix SH3BGR PF04908.15 KII74175.1 - 0.06 13.5 0.1 0.26 11.5 0.1 2.1 1 1 0 1 1 1 0 SH3-binding, glutamic acid-rich protein DUF2431 PF10354.9 KII74175.1 - 0.16 12.2 2.2 1 9.6 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF2431) Pet20 PF08692.10 KII74175.1 - 1.9 9.2 0.0 1.9 9.2 0.0 3.1 2 1 1 3 3 3 0 Mitochondrial protein Pet20 bZIP_2 PF07716.15 KII74177.1 - 0.00054 20.0 1.7 0.00054 20.0 1.7 2.1 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 KII74177.1 - 0.0013 18.8 1.2 0.0013 18.8 1.2 2.3 2 0 0 2 2 2 1 bZIP transcription factor Thioredoxin_8 PF13905.6 KII74177.1 - 0.039 14.3 0.7 0.16 12.3 0.2 2.2 2 1 0 2 2 2 0 Thioredoxin-like Chisel PF15355.6 KII74177.1 - 0.09 13.0 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Stretch-responsive small skeletal muscle X protein, Chisel RICH PF05062.12 KII74177.1 - 0.17 12.3 1.2 0.26 11.6 0.1 1.8 2 0 0 2 2 2 0 RICH domain Ead_Ea22 PF13935.6 KII74177.1 - 0.17 12.5 0.4 0.33 11.6 0.4 1.4 1 0 0 1 1 1 0 Ead/Ea22-like protein GBP PF02263.19 KII74178.1 - 1.8e-45 155.2 0.0 2.2e-45 155.0 0.0 1.0 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 KII74179.1 - 0.0016 17.9 0.3 0.0021 17.5 0.3 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain DUF2207 PF09972.9 KII74179.1 - 0.016 14.0 0.4 0.018 13.8 0.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) eIF-6 PF01912.18 KII74181.1 - 2e-74 249.3 0.1 2.3e-74 249.1 0.1 1.0 1 0 0 1 1 1 1 eIF-6 family Ncstrn_small PF18266.1 KII74181.1 - 8.4e-05 22.6 0.0 0.001 19.1 0.0 2.2 2 1 0 2 2 2 1 Nicastrin small lobe DUF4688 PF15752.5 KII74181.1 - 0.16 11.2 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4688) PHF5 PF03660.14 KII74182.1 - 1.1e-48 163.7 13.3 1.5e-48 163.3 13.3 1.1 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 KII74182.1 - 0.096 10.5 6.5 0.1 10.5 6.5 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 FliG_C PF01706.16 KII74183.1 - 0.13 12.4 0.1 0.48 10.6 0.1 1.8 1 1 0 1 1 1 0 FliG C-terminal domain KH_8 PF17903.1 KII74185.1 - 2.6e-07 30.6 0.1 5.1e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 KII74185.1 - 0.0014 18.4 0.2 0.0029 17.4 0.2 1.5 1 0 0 1 1 1 1 KH domain TM1586_NiRdase PF14512.6 KII74189.1 - 0.06 12.9 0.1 0.072 12.7 0.1 1.2 1 0 0 1 1 1 0 Putative TM nitroreductase Cyclase PF04199.13 KII74189.1 - 0.18 12.0 0.0 0.25 11.6 0.0 1.2 1 0 0 1 1 1 0 Putative cyclase RVP_2 PF08284.11 KII74190.1 - 0.00027 20.7 0.5 0.00058 19.7 0.5 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 KII74190.1 - 2.2 8.5 6.2 0.11 12.7 0.6 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII74190.1 - 2.8 7.8 4.6 6.2 6.6 0.3 2.5 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.27 KII74191.1 - 7.3e-09 35.5 0.0 2.1e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII74192.1 - 7e-20 70.9 0.0 1.2e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74192.1 - 7e-11 42.3 0.0 1.2e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74196.1 - 1.7e-10 40.8 0.1 6.6e-10 38.9 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spuma_A9PTase PF03539.14 KII74196.1 - 0.053 13.6 0.2 0.1 12.8 0.2 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) MULE PF10551.9 KII74199.1 - 6.3e-15 55.4 0.0 1.2e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain FLYWCH PF04500.16 KII74199.1 - 2.3e-08 34.0 0.2 4.7e-08 33.0 0.2 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain DDE_1 PF03184.19 KII74202.1 - 0.0017 18.0 0.0 0.002 17.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1664 PF07889.12 KII74205.1 - 0.02 15.0 0.7 0.037 14.1 0.7 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TEX12 PF15219.6 KII74205.1 - 0.024 15.0 0.2 3.6 8.0 0.0 2.2 1 1 1 2 2 2 0 Testis-expressed 12 PGM_PMM_I PF02878.16 KII74207.1 - 1.4e-26 92.9 0.0 2.1e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 KII74207.1 - 1.5e-20 73.5 0.0 3.6e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 KII74207.1 - 1.3e-11 45.0 0.0 4.1e-11 43.4 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 KII74207.1 - 0.00019 21.5 0.0 0.00039 20.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DBR1 PF05011.13 KII74208.1 - 9.3e-13 48.8 0.3 9.2e-11 42.3 0.3 2.3 1 1 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 KII74208.1 - 3.3e-06 27.8 2.4 5.6e-06 27.0 2.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DMAP1 PF05499.12 KII74209.1 - 1.9e-24 86.4 0.0 1.9e-24 86.4 0.0 1.6 2 0 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) DDRGK PF09756.9 KII74210.1 - 3.1e-45 154.1 23.6 3.9e-45 153.7 23.6 1.1 1 0 0 1 1 1 1 DDRGK domain FeoC PF09012.10 KII74210.1 - 0.0019 18.2 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 2 FeoC like transcriptional regulator Peptidase_S49_N PF08496.10 KII74210.1 - 0.062 13.4 0.3 0.062 13.4 0.3 2.3 1 1 1 2 2 2 0 Peptidase family S49 N-terminal DUF4777 PF16007.5 KII74210.1 - 0.1 12.9 0.0 0.44 10.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4777) CLPTM1 PF05602.12 KII74210.1 - 0.11 11.5 1.0 0.12 11.4 1.0 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) WTX PF09422.10 KII74210.1 - 0.35 9.9 9.6 0.46 9.5 9.6 1.0 1 0 0 1 1 1 0 WTX protein NPR3 PF03666.13 KII74210.1 - 0.36 9.6 8.1 0.52 9.0 8.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4381 PF14316.6 KII74210.1 - 1.4 9.1 4.0 21 5.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Asp-B-Hydro_N PF05279.11 KII74210.1 - 1.7 8.7 21.3 2 8.4 21.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF5081 PF16887.5 KII74210.1 - 2.3 7.2 14.8 1.6 7.7 12.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5081) Atg14 PF10186.9 KII74210.1 - 2.4 7.2 13.0 3 6.8 13.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 KII74210.1 - 8.6 5.6 14.1 14 4.9 14.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PDZ_6 PF17820.1 KII74211.1 - 5.5e-10 39.0 0.0 1e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KII74211.1 - 7.7e-10 39.0 0.0 1.5e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII74211.1 - 4.7e-06 26.8 0.0 1.2e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain FlpD PF02662.16 KII74211.1 - 0.013 15.5 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit DUF4299 PF14132.6 KII74211.1 - 0.013 14.9 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4299) Leo1 PF04004.13 KII74212.1 - 4.5e-45 153.5 0.1 9.4e-45 152.4 0.0 1.6 2 0 0 2 2 2 1 Leo1-like protein RRM_1 PF00076.22 KII74213.1 - 2.5e-14 52.8 0.0 3.7e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldedh PF00171.22 KII74215.1 - 5.4e-06 25.2 0.1 6.3e-06 25.0 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SWIRM-assoc_2 PF16496.5 KII74216.1 - 1.3e-05 24.3 0.2 1.4e-05 24.2 0.2 1.1 1 0 0 1 1 1 1 SWIRM-associated domain at the N-terminal BRCT_2 PF16589.5 KII74216.1 - 0.00016 22.0 0.2 0.00041 20.7 0.0 1.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KII74216.1 - 0.027 14.8 0.1 0.059 13.8 0.0 1.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain DUF3938 PF13074.6 KII74216.1 - 0.041 14.1 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3938) SWIRM PF04433.17 KII74217.1 - 1.3e-15 57.5 0.4 4.9e-15 55.6 0.1 2.2 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 KII74217.1 - 9.1e-08 32.0 5.4 1.7e-07 31.1 5.4 1.4 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 KII74217.1 - 6e-05 23.2 0.0 0.00013 22.1 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KII74217.1 - 0.00051 20.2 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_3 PF16498.5 KII74217.1 - 0.0045 17.2 0.4 0.025 14.8 0.1 2.2 2 0 0 2 2 2 1 SWIRM-associated domain at the C-terminal DUF572 PF04502.13 KII74217.1 - 0.041 13.5 0.1 0.067 12.8 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) EFG_C PF00679.24 KII74218.1 - 1.5e-24 85.8 0.0 4.8e-24 84.2 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_IV PF03764.18 KII74218.1 - 8.1e-22 77.3 0.0 1.5e-21 76.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 KII74218.1 - 1.7e-12 47.5 0.0 3.5e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KII74218.1 - 1.2e-07 31.7 0.0 2.9e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II DUF5316 PF17247.2 KII74218.1 - 0.022 14.8 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5316) Proteasome PF00227.26 KII74221.1 - 4.9e-27 94.6 0.0 6.6e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit PsaM PF07465.13 KII74222.1 - 0.096 12.4 0.8 1.9 8.3 1.3 2.2 2 0 0 2 2 2 0 Photosystem I protein M (PsaM) zf-CCHC PF00098.23 KII74223.1 - 0.033 14.3 1.1 0.047 13.8 1.1 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 KII74223.1 - 0.079 12.7 0.8 0.12 12.1 0.8 1.3 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RT_RNaseH_2 PF17919.1 KII74224.1 - 1.9e-05 24.6 0.0 3.9e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74224.1 - 2.2e-05 24.7 0.0 5.3e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase F1F0-ATPsyn_F PF10791.9 KII74224.1 - 0.094 13.2 0.1 0.21 12.1 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi rve PF00665.26 KII74227.1 - 4.8e-22 78.4 0.0 7.9e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII74227.1 - 0.0018 18.5 0.1 0.017 15.3 0.0 2.1 2 0 0 2 2 2 1 DDE domain MLVIN_C PF18697.1 KII74227.1 - 0.023 14.8 0.1 0.059 13.5 0.1 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rve_3 PF13683.6 KII74227.1 - 0.027 14.3 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 Integrase core domain Integrase_H2C2 PF17921.1 KII74227.1 - 0.048 13.8 0.4 0.16 12.1 0.3 2.0 2 0 0 2 2 2 0 Integrase zinc binding domain Transcript_VP30 PF11507.8 KII74227.1 - 0.15 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Ebola virus-specific transcription factor VP30 BNR_6 PF15899.5 KII74229.1 - 0.0045 16.9 0.1 0.0045 16.9 0.1 2.5 3 0 0 3 3 3 1 BNR-Asp box repeat Sortilin-Vps10 PF15902.5 KII74229.1 - 0.0055 15.5 0.3 0.0067 15.3 0.3 1.0 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, FLYWCH PF04500.16 KII74230.1 - 1.3e-10 41.2 0.2 3.5e-10 39.8 0.2 1.7 1 0 0 1 1 1 1 FLYWCH zinc finger domain 2-Hacid_dh_C PF02826.19 KII74231.1 - 2.6e-56 189.8 0.0 3.9e-56 189.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KII74231.1 - 9.9e-25 86.8 0.0 1.1e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KII74231.1 - 8e-06 26.1 0.0 2.2e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 KII74231.1 - 0.015 15.4 0.0 0.029 14.5 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain GFO_IDH_MocA PF01408.22 KII74231.1 - 0.11 13.3 0.0 0.27 12.1 0.0 1.8 1 1 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Na_sulph_symp PF00939.19 KII74232.1 - 4.3e-106 355.8 29.4 5.7e-106 355.4 29.4 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KII74232.1 - 4.6e-14 52.3 33.0 4.6e-14 52.3 33.0 1.6 1 1 1 2 2 2 2 Citrate transporter Amidohydro_3 PF07969.11 KII74232.1 - 6.1e-13 49.0 0.4 3.2e-05 23.6 0.2 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 KII74232.1 - 3.9e-10 39.6 3.7 1.5e-08 34.3 3.7 2.4 1 1 0 1 1 1 1 Amidohydrolase family DUF2242 PF10001.9 KII74233.1 - 0.2 11.9 0.2 0.2 11.9 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2242) Orthopox_A36R PF05950.11 KII74234.1 - 0.014 15.6 2.1 0.025 14.7 2.1 1.3 1 0 0 1 1 1 0 Orthopoxvirus A36R protein SR-25 PF10500.9 KII74235.1 - 0.0048 16.5 8.1 0.0053 16.4 8.1 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PIP49_N PF14875.6 KII74235.1 - 0.077 12.9 0.1 0.083 12.8 0.1 1.1 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 zf-CCCH_2 PF14608.6 KII74238.1 - 0.028 14.9 1.5 0.028 14.9 1.5 1.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger TetR_C_8 PF14278.6 KII74239.1 - 0.084 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region PDDEXK_3 PF13366.6 KII74241.1 - 0.14 12.6 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily PIF PF05092.12 KII74242.1 - 0.042 12.6 0.1 0.053 12.2 0.1 1.1 1 0 0 1 1 1 0 Per os infectivity LeuA_dimer PF08502.10 KII74242.1 - 0.14 12.1 0.5 0.3 11.0 0.5 1.6 1 1 0 1 1 1 0 LeuA allosteric (dimerisation) domain RPA_interact_C PF14768.6 KII74242.1 - 0.15 12.7 0.9 0.34 11.5 0.6 1.8 1 1 0 1 1 1 0 Replication protein A interacting C-terminal Nucleos_tra2_N PF01773.20 KII74244.1 - 0.11 13.1 0.0 0.2 12.3 0.0 1.3 1 0 0 1 1 1 0 Na+ dependent nucleoside transporter N-terminus BRAP2 PF07576.12 KII74249.1 - 0.06 13.6 0.0 0.18 12.0 0.0 1.8 2 0 0 2 2 2 0 BRCA1-associated protein 2 UPF0175 PF03683.13 KII74250.1 - 0.0025 17.5 0.0 0.21 11.3 0.0 2.2 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0175) DUF515 PF04415.12 KII74250.1 - 0.1 10.9 0.1 0.12 10.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) ocr PF08684.10 KII74252.1 - 0.017 15.6 0.0 0.028 14.9 0.0 1.3 1 0 0 1 1 1 0 DNA mimic ocr Kunitz_BPTI PF00014.23 KII74253.1 - 0.0068 16.6 14.0 0.011 15.9 4.7 2.8 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Flu_PA PF00603.17 KII74253.1 - 0.063 11.4 0.0 0.089 10.9 0.0 1.2 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PA SHE3 PF17078.5 KII74255.1 - 0.0028 17.4 5.3 0.013 15.2 5.3 1.9 1 1 0 1 1 1 1 SWI5-dependent HO expression protein 3 Sec2p PF06428.11 KII74255.1 - 0.021 14.8 2.1 0.032 14.2 0.5 1.9 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p TMPIT PF07851.13 KII74255.1 - 0.031 13.5 2.4 0.036 13.3 2.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein 3-HAO PF06052.12 KII74255.1 - 0.042 13.5 0.1 0.062 12.9 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase LOB PF03195.14 KII74255.1 - 0.12 13.0 0.7 3 8.5 0.1 2.7 2 1 1 3 3 3 0 Lateral organ boundaries (LOB) domain DivIC PF04977.15 KII74255.1 - 0.15 11.9 6.1 4.3 7.2 0.6 2.8 2 1 1 3 3 3 0 Septum formation initiator DUF1882 PF08966.11 KII74258.1 - 0.013 15.7 0.1 0.026 14.8 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1882) NUP214 PF16755.5 KII74260.1 - 0.078 12.2 0.1 0.078 12.2 0.1 1.1 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Sortilin_C PF15901.5 KII74261.1 - 1.9e-09 38.1 0.8 2.3e-09 37.8 0.8 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Noc2 PF03715.13 KII74261.1 - 0.14 11.4 0.1 0.19 11.0 0.1 1.1 1 0 0 1 1 1 0 Noc2p family Myosin_N PF02736.19 KII74263.1 - 0.015 15.1 0.1 0.04 13.7 0.1 1.7 1 1 0 1 1 1 0 Myosin N-terminal SH3-like domain RVT_1 PF00078.27 KII74264.1 - 2.7e-18 66.3 0.1 3.3e-18 66.0 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) VirC1 PF07015.11 KII74265.1 - 0.13 11.5 0.0 0.14 11.4 0.0 1.0 1 0 0 1 1 1 0 VirC1 protein DUF4411 PF14367.6 KII74267.1 - 0.041 13.8 1.6 0.055 13.4 1.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4411) DDE_1 PF03184.19 KII74269.1 - 1.5e-19 70.3 1.1 4.4e-19 68.8 1.1 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII74269.1 - 7.9e-07 29.0 0.1 4.8e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DUF4261 PF14080.6 KII74273.1 - 0.023 14.8 0.1 0.035 14.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) DFRP_C PF16543.5 KII74276.1 - 5.8e-18 65.2 1.7 5.8e-18 65.2 1.7 2.1 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH_4 PF18044.1 KII74276.1 - 8.1e-09 35.1 7.2 1.2e-06 28.2 1.1 3.2 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 KII74276.1 - 6e-08 33.4 8.5 1.2e-05 25.9 0.4 3.5 2 1 1 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 KII74276.1 - 1.2e-06 28.4 15.5 9.2e-06 25.5 5.9 3.0 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 KII74276.1 - 2.1e-06 27.5 0.7 2.1e-06 27.5 0.7 2.9 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 KII74276.1 - 0.052 13.8 8.9 0.21 11.8 1.4 3.0 2 1 0 3 3 3 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 KII74276.1 - 0.056 13.9 9.7 0.18 12.3 2.6 2.8 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger gag-asp_proteas PF13975.6 KII74278.1 - 9.3e-07 29.3 0.0 2.5e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII74278.1 - 3.4e-06 27.6 0.0 7.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 KII74278.1 - 0.0058 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII74278.1 - 0.025 14.9 0.0 0.06 13.7 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease RVT_1 PF00078.27 KII74279.1 - 6e-26 91.3 0.3 8.9e-26 90.8 0.3 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) hnRNP_Q_AcD PF18360.1 KII74279.1 - 0.19 11.7 0.3 30 4.7 0.0 3.3 3 0 0 3 3 3 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain DUF4100 PF13352.6 KII74281.1 - 0.01 15.6 2.9 0.012 15.5 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) Rho_N PF07498.12 KII74281.1 - 0.032 14.1 0.1 0.032 14.1 0.1 1.7 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain DUF1400 PF07176.11 KII74281.1 - 0.06 13.6 0.1 0.08 13.2 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1400) Far-17a_AIG1 PF04750.14 KII74285.1 - 0.15 11.3 0.1 0.22 10.8 0.1 1.2 1 0 0 1 1 1 0 FAR-17a/AIG1-like protein DcpS_C PF11969.8 KII74286.1 - 3.7e-27 95.0 0.2 4.2e-27 94.9 0.2 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 KII74286.1 - 3e-26 92.0 0.2 3.7e-26 91.7 0.2 1.1 1 0 0 1 1 1 1 HIT domain DUF424 PF04242.13 KII74287.1 - 0.019 15.2 0.2 0.052 13.8 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF424) DUF4984 PF16372.5 KII74287.1 - 0.036 14.0 3.4 3 7.7 0.4 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4984) Pkinase PF00069.25 KII74289.1 - 8.7e-59 199.0 0.0 8.7e-59 199.0 0.0 3.0 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII74289.1 - 3.7e-34 118.2 2.1 4.1e-34 118.0 0.0 2.1 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 KII74289.1 - 6.3e-05 22.4 3.9 0.00026 20.4 0.0 3.2 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 KII74289.1 - 0.011 15.7 1.8 0.048 13.6 0.0 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family Phospholip_A2_3 PF09056.11 KII74289.1 - 0.47 11.1 3.3 0.61 10.7 0.3 2.6 2 0 0 2 2 2 0 Prokaryotic phospholipase A2 dNK PF01712.19 KII74290.1 - 9.7e-36 123.5 0.1 1.1e-35 123.4 0.1 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 KII74290.1 - 0.00025 21.6 0.1 0.00099 19.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain Dynamin_N PF00350.23 KII74290.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Dynamin family HipN PF18253.1 KII74290.1 - 0.13 12.0 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Hsp70-interacting protein N N-terminal domain Thymidylate_kin PF02223.17 KII74290.1 - 0.14 11.8 0.0 7.6 6.2 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase Pkinase PF00069.25 KII74291.1 - 2.5e-27 95.9 6.5 3.2e-27 95.6 6.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII74291.1 - 7e-22 77.9 1.9 9.9e-22 77.5 1.9 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KII74291.1 - 0.0003 20.8 0.0 0.079 12.9 0.0 2.1 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KII74291.1 - 0.00037 19.9 0.3 0.00057 19.3 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KII74291.1 - 0.0008 19.1 5.5 0.07 12.7 1.4 2.2 1 1 1 2 2 2 2 Choline/ethanolamine kinase RIO1 PF01163.22 KII74291.1 - 0.0046 16.6 5.2 0.054 13.1 1.9 2.2 1 1 1 2 2 2 2 RIO1 family RecJ_OB PF17768.1 KII74291.1 - 0.037 14.3 0.1 0.14 12.4 0.1 2.1 1 1 0 1 1 1 0 RecJ OB domain HTH_33 PF13592.6 KII74292.1 - 0.0012 18.5 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII74292.1 - 0.0087 16.3 1.2 0.079 13.2 0.1 2.2 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.6 KII74292.1 - 0.095 13.3 0.1 0.55 10.9 0.0 2.1 1 1 1 2 2 2 0 Homeodomain-like domain Helicase_C_2 PF13307.6 KII74293.1 - 9.4e-51 172.4 4.9 1.9e-50 171.4 0.1 3.0 3 0 0 3 3 3 1 Helicase C-terminal domain DEAD_2 PF06733.15 KII74293.1 - 1.4e-44 151.8 9.0 2.7e-44 150.9 9.0 1.5 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 KII74293.1 - 2.8e-05 24.0 0.0 0.0063 16.3 0.0 2.7 2 1 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 KII74293.1 - 5.6e-05 23.2 0.3 0.12 12.3 0.1 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_11 PF13086.6 KII74293.1 - 0.0043 16.9 1.0 0.011 15.5 1.0 1.6 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KII74293.1 - 0.016 14.6 0.0 4 6.8 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein ARL2_Bind_BART PF11527.8 KII74293.1 - 0.89 9.7 12.2 2 8.5 1.1 3.8 3 1 0 3 3 3 0 The ARF-like 2 binding protein BART zf-Nse PF11789.8 KII74294.1 - 1.1e-17 63.6 0.2 1.9e-17 62.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 KII74294.1 - 1.8e-05 24.7 0.0 3.6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-MIZ PF02891.20 KII74294.1 - 0.00023 20.8 0.1 0.00043 20.0 0.1 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger DUF1664 PF07889.12 KII74294.1 - 0.0049 16.9 2.8 0.052 13.6 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Stomoxyn PF11585.8 KII74294.1 - 0.0076 16.2 0.3 0.29 11.2 0.3 2.8 2 0 0 2 2 2 1 Insect antimicrobial peptide, stomoxyn Rtf2 PF04641.12 KII74294.1 - 0.0081 15.5 0.1 0.017 14.5 0.1 1.5 1 1 0 1 1 1 1 Rtf2 RING-finger Rabaptin PF03528.15 KII74294.1 - 0.012 14.3 0.8 0.014 14.1 0.8 1.1 1 0 0 1 1 1 0 Rabaptin Raftlin PF15250.6 KII74294.1 - 0.015 14.1 0.2 0.018 13.8 0.2 1.1 1 0 0 1 1 1 0 Raftlin Vip3A_N PF12495.8 KII74294.1 - 0.027 14.4 1.5 0.039 13.8 1.5 1.4 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal Vma12 PF11712.8 KII74294.1 - 0.03 14.4 0.3 0.037 14.1 0.3 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase CENP-K PF11802.8 KII74294.1 - 0.036 13.7 2.5 0.072 12.7 2.5 1.5 1 1 0 1 1 1 0 Centromere-associated protein K mRNA_stabil PF13929.6 KII74294.1 - 0.04 12.9 1.2 0.12 11.3 0.1 1.9 1 1 1 2 2 2 0 mRNA stabilisation Arteri_GP4 PF02497.15 KII74294.1 - 0.044 13.9 0.3 0.14 12.3 0.1 1.8 1 1 1 2 2 2 0 Arterivirus glycoprotein L31 PF09784.9 KII74294.1 - 0.044 14.2 3.5 4.9 7.6 0.5 2.3 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 DnaB_2 PF07261.11 KII74294.1 - 0.05 13.4 0.5 0.14 11.9 0.3 1.8 1 1 1 2 2 2 0 Replication initiation and membrane attachment DUF1910 PF08928.10 KII74294.1 - 0.064 13.3 0.9 7.7 6.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) RPW8 PF05659.11 KII74294.1 - 0.15 11.8 3.0 0.7 9.6 2.9 2.0 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 KAR PF15222.6 KII74294.1 - 0.17 12.2 3.9 2.8 8.3 0.3 2.2 1 1 1 2 2 2 0 Kidney androgen-regulated Fib_alpha PF08702.10 KII74294.1 - 0.9 9.7 7.4 1.4 9.1 5.5 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DASH_Dad1 PF08649.10 KII74294.1 - 6.8 7.0 6.6 5.2 7.3 1.6 2.8 2 1 1 3 3 3 0 DASH complex subunit Dad1 NUMOD1 PF07453.13 KII74296.1 - 0.05 13.9 0.5 9.2 6.7 0.0 3.0 3 0 0 3 3 3 0 NUMOD1 domain LRR_4 PF12799.7 KII74297.1 - 2.9e-15 56.1 11.2 6.5e-07 29.6 1.3 2.9 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KII74297.1 - 8.1e-15 54.8 0.0 1e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 KII74297.1 - 1.7e-08 34.1 2.2 0.00032 20.4 1.7 3.1 2 1 0 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 KII74297.1 - 4.1e-08 32.7 4.2 0.027 14.5 0.3 4.8 3 1 1 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 KII74297.1 - 2.2e-07 30.5 3.6 0.72 10.6 0.2 5.0 5 0 0 5 5 5 2 Leucine Rich Repeat Daxx PF03344.15 KII74298.1 - 0.016 15.3 1.2 4.7 7.4 0.0 2.4 2 0 0 2 2 2 0 Daxx N-terminal Rassf1C-interacting domain Cys_rich_FGFR PF00839.17 KII74298.1 - 0.3 11.3 2.2 15 5.8 0.4 2.3 2 0 0 2 2 2 0 Cysteine rich repeat Pacs-1 PF10254.9 KII74303.1 - 3.2e-14 52.7 1.5 3.6e-14 52.5 1.5 1.0 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein BTG PF07742.12 KII74304.1 - 5.7e-19 68.1 0.0 7.8e-19 67.6 0.0 1.2 1 0 0 1 1 1 1 BTG family C2 PF00168.30 KII74305.1 - 0.014 15.7 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 0 C2 domain Fer2_3 PF13085.6 KII74306.1 - 1.7e-32 111.7 0.0 2.5e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 KII74306.1 - 1.9e-08 34.6 6.2 1.9e-08 34.6 6.2 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 KII74306.1 - 4.2e-08 33.6 3.7 4.2e-08 33.6 3.7 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 KII74306.1 - 6.4e-08 32.6 2.3 6.4e-08 32.6 2.3 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 KII74306.1 - 3.8e-05 24.2 2.1 3.8e-05 24.2 2.1 2.6 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 KII74306.1 - 0.00052 20.1 3.6 0.00052 20.1 3.6 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 KII74306.1 - 0.028 14.4 1.8 0.028 14.4 1.8 2.0 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain CTD_bind PF04818.13 KII74307.1 - 2.6e-05 25.0 0.0 0.00012 22.8 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. TMIE PF16038.5 KII74309.1 - 0.0033 17.2 1.7 0.0079 16.0 1.7 1.6 1 0 0 1 1 1 1 TMIE protein Shisa PF13908.6 KII74309.1 - 0.006 16.9 0.9 0.0078 16.5 0.9 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator RT_RNaseH PF17917.1 KII74310.1 - 2.9e-37 127.1 0.0 6.6e-37 126.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74310.1 - 7.3e-30 103.0 0.0 1.5e-29 102.0 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII74310.1 - 3.6e-20 72.3 0.0 6.6e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74310.1 - 1.2e-16 60.6 1.8 1.2e-16 60.6 1.8 2.5 3 0 0 3 3 3 1 Integrase zinc binding domain rve_3 PF13683.6 KII74310.1 - 0.002 17.9 0.0 0.0057 16.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII74310.1 - 0.0079 16.3 0.1 0.024 14.7 0.1 1.8 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVT_1 PF00078.27 KII74311.1 - 2e-27 96.2 0.1 3.9e-27 95.2 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVP PF00077.20 KII74311.1 - 0.00012 22.4 0.0 0.00028 21.1 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII74311.1 - 0.00019 21.9 0.1 0.00038 20.9 0.1 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Rogdi_lz PF10259.9 KII74311.1 - 0.0065 16.0 0.1 0.089 12.2 0.0 2.2 2 0 0 2 2 2 1 Rogdi leucine zipper containing protein Asp_protease_2 PF13650.6 KII74311.1 - 0.0094 16.6 0.0 0.028 15.1 0.0 1.8 1 1 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII74311.1 - 0.01 15.8 2.1 0.01 15.8 2.1 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 KII74311.1 - 0.51 10.4 10.0 0.15 12.1 1.7 2.7 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII74311.1 - 6.3 6.6 9.6 9.7 6.0 3.3 2.5 1 1 1 2 2 2 0 Zinc knuckle rve PF00665.26 KII74313.1 - 4.7e-15 55.8 0.0 9.2e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII74313.1 - 0.00017 21.3 0.0 0.0004 20.1 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH_2 PF17919.1 KII74317.1 - 3.2e-13 49.6 0.1 6.9e-13 48.5 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74317.1 - 1.1e-08 35.3 0.0 3.3e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase YvbH_ext PF11724.8 KII74317.1 - 0.078 13.3 0.1 1.1 9.6 0.1 2.6 2 0 0 2 2 2 0 YvbH-like oligomerisation region CHCH PF06747.13 KII74321.1 - 0.00088 19.3 0.9 0.0016 18.5 0.9 1.5 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 KII74321.1 - 0.018 15.1 2.1 0.13 12.3 0.3 2.2 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, MTCP1 PF08991.10 KII74321.1 - 0.041 14.1 1.9 0.063 13.5 1.9 1.3 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type Endopep_inhib PF16800.5 KII74321.1 - 0.052 13.5 0.8 6 6.8 0.4 2.0 1 1 1 2 2 2 0 IseA DL-endopeptidase inhibitor NDUF_B7 PF05676.13 KII74321.1 - 0.062 13.0 1.4 0.09 12.5 1.4 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) EPOP PF15223.6 KII74321.1 - 0.079 12.3 0.1 0.097 12.0 0.1 1.1 1 0 0 1 1 1 0 Elongin BC and Polycomb repressive complex 2-associated protein T3SS_needle_F PF09392.10 KII74321.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.2 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF HEAT PF02985.22 KII74322.1 - 0.00024 21.1 0.4 0.23 11.8 0.0 3.8 3 0 0 3 3 3 1 HEAT repeat IFRD PF05004.13 KII74322.1 - 0.0019 17.4 0.1 0.0028 16.8 0.1 1.3 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 KII74322.1 - 0.0066 16.5 0.3 0.12 12.5 0.1 2.6 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.8 KII74322.1 - 0.057 13.4 0.0 0.092 12.7 0.0 1.4 1 1 0 1 1 1 0 Myosin-binding striated muscle assembly central HEAT_2 PF13646.6 KII74322.1 - 0.06 13.7 0.1 5.7 7.4 0.0 2.6 2 1 1 3 3 3 0 HEAT repeats Vac14_Fab1_bd PF12755.7 KII74322.1 - 0.061 13.9 0.1 0.18 12.5 0.0 1.8 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 KII74322.1 - 0.091 11.9 0.0 0.22 10.6 0.0 1.6 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal DDE_Tnp_IS1595 PF12762.7 KII74324.1 - 9e-09 35.5 0.0 1.9e-08 34.4 0.0 1.6 2 0 0 2 2 2 1 ISXO2-like transposase domain DUF1335 PF07056.11 KII74326.1 - 0.021 14.9 0.2 0.026 14.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) RVT_1 PF00078.27 KII74331.1 - 0.00051 19.6 0.0 0.00051 19.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDE_3 PF13358.6 KII74333.1 - 4.1e-11 42.8 0.1 8.7e-05 22.3 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease AAT PF03417.16 KII74333.1 - 0.013 15.2 0.1 0.016 14.9 0.1 1.1 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Imm-NTF2-2 PF15631.6 KII74333.1 - 0.016 15.5 0.0 0.027 14.7 0.0 1.3 1 0 0 1 1 1 0 NTF2 fold immunity protein 2OG-FeII_Oxy_3 PF13640.6 KII74334.1 - 1.5e-13 51.4 0.4 6.3e-13 49.4 0.1 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily EF-hand_7 PF13499.6 KII74334.1 - 0.087 13.3 0.9 0.22 12.0 0.9 1.7 1 0 0 1 1 1 0 EF-hand domain pair SpoU_sub_bind PF08032.12 KII74334.1 - 0.14 12.4 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding DDE_1 PF03184.19 KII74338.1 - 1.4e-05 24.8 0.0 2.1e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII74339.1 - 0.0025 17.5 0.1 0.0044 16.7 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF760 PF05542.11 KII74340.1 - 0.082 13.3 0.6 4.3 7.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF760) RT_RNaseH PF17917.1 KII74345.1 - 4.2e-08 33.4 0.0 6.7e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74345.1 - 6.1e-07 29.4 0.1 1e-06 28.7 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74346.1 - 0.00016 21.9 0.0 0.011 16.0 0.0 2.7 3 0 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74346.1 - 0.00071 19.6 0.0 0.48 10.5 0.0 2.5 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74346.1 - 0.016 14.7 0.4 0.028 13.9 0.4 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Thymidylat_synt PF00303.19 KII74348.1 - 1e-116 388.8 0.0 1.2e-116 388.6 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase HD_3 PF13023.6 KII74349.1 - 9.8e-26 90.6 0.2 1.2e-25 90.4 0.2 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 KII74349.1 - 3e-07 30.4 0.1 3.4e-07 30.2 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HAD_2 PF13419.6 KII74349.1 - 0.059 13.4 0.5 0.11 12.6 0.3 1.5 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase HD PF01966.22 KII74349.1 - 0.11 12.8 0.1 0.54 10.5 0.1 2.0 1 1 0 1 1 1 0 HD domain Clusterin PF01093.17 KII74350.1 - 0.071 12.1 6.3 0.086 11.9 6.3 1.1 1 0 0 1 1 1 0 Clusterin WD40 PF00400.32 KII74351.1 - 0.1 13.5 0.0 6.2 7.9 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat APC_N_CC PF16689.5 KII74351.1 - 0.17 11.9 0.1 0.38 10.9 0.1 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain WD40 PF00400.32 KII74352.1 - 0.021 15.7 1.7 9.2 7.3 0.0 3.3 4 0 0 4 4 4 0 WD domain, G-beta repeat PFK PF00365.20 KII74353.1 - 1.6e-34 119.5 0.4 1.8e-34 119.3 0.4 1.0 1 0 0 1 1 1 1 Phosphofructokinase PFK PF00365.20 KII74354.1 - 1e-126 422.0 0.0 2.3e-68 230.6 0.0 2.1 2 0 0 2 2 2 2 Phosphofructokinase ATPgrasp_YheCD PF14398.6 KII74354.1 - 0.063 12.5 0.0 0.32 10.2 0.0 2.1 3 0 0 3 3 3 0 YheC/D like ATP-grasp NAD4L PF06235.11 KII74356.1 - 0.04 13.9 3.7 0.043 13.8 2.1 1.8 2 0 0 2 2 2 0 NADH dehydrogenase subunit 4L (NAD4L) DUF4793 PF16041.5 KII74356.1 - 0.054 13.7 1.5 0.1 12.8 1.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4793) DUF4227 PF14004.6 KII74356.1 - 2 8.5 4.7 0.8 9.7 2.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) PNMA PF14893.6 KII74357.1 - 0.2 11.0 0.0 0.29 10.5 0.0 1.3 1 1 0 1 1 1 0 PNMA RT_RNaseH_2 PF17919.1 KII74358.1 - 6e-33 112.9 0.0 1.4e-32 111.6 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74358.1 - 4.1e-31 107.4 0.0 7.8e-31 106.5 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74358.1 - 3.8e-21 75.6 0.0 8e-21 74.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII74358.1 - 5.2e-20 71.8 0.0 1.2e-19 70.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74358.1 - 1.9e-16 59.9 0.3 1.9e-16 59.9 0.3 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII74358.1 - 1.4e-06 28.8 0.0 2.6e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII74358.1 - 0.00033 21.2 0.0 0.00073 20.1 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 KII74358.1 - 0.0019 18.2 2.8 0.0019 18.2 2.8 2.7 2 0 0 2 2 2 1 Zinc knuckle rve_3 PF13683.6 KII74358.1 - 0.0038 17.0 0.0 0.0088 15.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 KII74358.1 - 0.036 14.4 0.0 0.1 12.9 0.0 1.8 1 1 0 1 1 1 0 Retroviral aspartyl protease RVP_2 PF08284.11 KII74358.1 - 0.069 12.9 0.3 0.19 11.5 0.3 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease MULE PF10551.9 KII74361.1 - 0.0054 17.1 0.0 0.016 15.6 0.0 1.9 1 0 0 1 1 1 1 MULE transposase domain DUF4957 PF16318.5 KII74362.1 - 0.12 12.3 0.1 0.17 11.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4957) DDE_3 PF13358.6 KII74365.1 - 1.2e-12 47.8 0.1 1.3e-12 47.6 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.6 KII74366.1 - 5.4e-05 23.1 0.0 7.6e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 KII74366.1 - 0.00016 21.4 0.1 0.00026 20.7 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain EF-hand_7 PF13499.6 KII74366.1 - 0.0034 17.8 0.1 0.025 15.0 0.1 2.1 1 1 0 1 1 1 1 EF-hand domain pair HTH_32 PF13565.6 KII74366.1 - 0.0036 17.9 0.0 0.37 11.4 0.0 2.2 1 1 1 2 2 2 2 Homeodomain-like domain PAX PF00292.18 KII74366.1 - 0.0052 16.7 0.2 0.0064 16.4 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain EF-hand_8 PF13833.6 KII74366.1 - 0.11 12.4 0.3 3.5 7.6 0.2 2.3 1 1 1 2 2 2 0 EF-hand domain pair HTH_Crp_2 PF13545.6 KII74366.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain DUF929 PF06053.11 KII74366.1 - 0.19 11.0 0.0 0.22 10.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF929) rve PF00665.26 KII74371.1 - 7.2e-13 48.8 0.0 5.7e-12 45.9 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 KII74371.1 - 3.1e-12 46.4 0.0 8.2e-12 45.0 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74371.1 - 2.2e-05 24.7 0.1 0.00043 20.5 0.1 2.7 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase UPF0231 PF06062.11 KII74373.1 - 0.024 14.9 0.1 0.25 11.6 0.1 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0231) SNX17_FERM_C PF18116.1 KII74374.1 - 0.086 12.9 0.1 0.14 12.2 0.1 1.5 1 1 0 1 1 1 0 Sorting Nexin 17 FERM C-terminal domain DUF1759 PF03564.15 KII74376.1 - 0.00026 20.9 0.1 0.0004 20.3 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1759) gag-asp_proteas PF13975.6 KII74377.1 - 4.5e-05 23.9 0.0 6.8e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KII74377.1 - 0.00094 19.8 0.0 0.0014 19.3 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII74377.1 - 0.0078 16.5 0.0 0.015 15.6 0.0 1.4 1 1 0 1 1 1 1 Retroviral aspartyl protease RE_NgoPII PF09521.10 KII74377.1 - 0.011 14.9 0.1 0.011 14.9 0.1 1.1 1 0 0 1 1 1 0 NgoPII restriction endonuclease Asp_protease PF09668.10 KII74377.1 - 0.051 13.4 0.0 5.8 6.7 0.0 2.0 2 0 0 2 2 2 0 Aspartyl protease RT_RNaseH_2 PF17919.1 KII74379.1 - 4.4e-33 113.3 0.0 1e-32 112.1 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74379.1 - 4.7e-30 104.0 0.0 1.5e-29 102.4 0.0 1.9 2 0 0 2 2 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74379.1 - 3.3e-20 72.6 0.0 7.5e-20 71.4 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII74379.1 - 1.2e-19 70.7 0.0 2.9e-19 69.4 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74379.1 - 1.1e-13 51.0 0.2 4.9e-13 49.0 0.0 2.3 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII74379.1 - 3.6e-06 26.7 0.1 3.3e-05 23.6 0.0 2.7 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII74379.1 - 0.00018 21.7 0.0 0.00062 19.9 0.1 2.0 2 0 0 2 2 2 1 H2C2 zinc finger Agenet PF05641.12 KII74379.1 - 0.0065 16.9 0.4 0.022 15.2 0.1 2.2 2 0 0 2 2 2 1 Agenet domain HypA PF01155.19 KII74379.1 - 0.1 12.6 3.3 0.37 10.8 3.3 1.9 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF737 PF05300.11 KII74379.1 - 0.2 12.0 2.0 2.4 8.4 1.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF737) zf-CCHC PF00098.23 KII74379.1 - 3.3 7.9 15.2 0.029 14.5 6.1 2.4 2 0 0 2 2 2 0 Zinc knuckle DUF5366 PF17328.2 KII74380.1 - 0.017 15.2 0.9 0.027 14.6 0.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5366) DUF1064 PF06356.11 KII74381.1 - 0.056 13.8 0.3 0.069 13.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1064) Aquarius_N PF16399.5 KII74383.1 - 6.1e-219 729.1 14.8 1.1e-218 728.2 14.8 1.3 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 KII74383.1 - 5.6e-31 108.3 1.3 9.8e-30 104.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_12 PF13087.6 KII74383.1 - 3.7e-29 101.8 0.2 5.8e-28 97.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KII74383.1 - 3.4e-10 40.4 0.2 1.7e-09 38.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KII74383.1 - 3.2e-06 27.0 0.0 0.019 14.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 KII74383.1 - 0.00022 21.3 0.1 0.00022 21.3 0.1 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KII74383.1 - 0.00022 21.0 2.5 0.00085 19.1 0.1 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Parvo_NS1 PF01057.17 KII74383.1 - 0.0085 15.2 0.0 0.021 13.9 0.0 1.6 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA PF00004.29 KII74383.1 - 0.01 16.2 0.0 0.036 14.5 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SGBP_B_XBD PF18329.1 KII74383.1 - 0.012 15.6 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 Surface glycan-binding protein B xyloglucan binding domain UvrD_C_2 PF13538.6 KII74383.1 - 0.039 13.8 0.1 0.077 12.8 0.1 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_5 PF07728.14 KII74383.1 - 0.062 13.3 0.2 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 KII74383.1 - 0.063 12.5 0.0 0.063 12.5 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 KII74383.1 - 0.082 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KII74383.1 - 3.5 8.1 7.7 3.4 8.1 0.0 3.4 3 1 1 4 4 3 0 AAA domain Pyr_redox_2 PF07992.14 KII74384.1 - 0.14 11.4 0.1 0.22 10.7 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1825 PF08855.10 KII74384.1 - 0.19 11.7 2.1 1.3 9.0 0.1 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF1825) Imm3 PF14425.6 KII74384.1 - 0.28 11.2 4.9 1.5 8.9 0.2 3.9 3 1 0 3 3 3 0 Immunity protein Imm3 PspA_IM30 PF04012.12 KII74384.1 - 0.76 9.3 14.6 0.14 11.7 2.4 2.9 3 0 0 3 3 3 0 PspA/IM30 family DUF4570 PF15134.6 KII74384.1 - 2.7 8.1 6.3 8.1 6.5 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4570) NUDIX_2 PF13869.6 KII74385.1 - 1.3e-66 223.8 0.1 1.4e-66 223.7 0.1 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 KII74385.1 - 0.073 13.1 0.0 0.094 12.8 0.0 1.2 1 0 0 1 1 1 0 NUDIX domain Omega-toxin PF06357.11 KII74386.1 - 0.16 11.8 0.1 0.29 11.0 0.1 1.3 1 0 0 1 1 1 0 Omega-atracotoxin WD40 PF00400.32 KII74388.1 - 1e-18 67.3 10.6 0.00028 21.6 1.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KII74388.1 - 0.00067 19.9 0.0 12 6.3 0.0 4.8 2 1 4 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KII74388.1 - 0.1 13.1 0.2 17 6.1 0.0 3.4 4 0 0 4 4 4 0 PQQ-like domain DDE_Tnp_IS1595 PF12762.7 KII74389.1 - 3.9e-13 49.7 0.1 4.1e-13 49.6 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain tRNA_synt_1c_R1 PF04558.15 KII74390.1 - 8e-26 91.0 0.0 1.2e-25 90.4 0.0 1.2 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_synt_1c_R2 PF04557.15 KII74390.1 - 4.4e-07 30.7 0.0 8.6e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Nrf1_DNA-bind PF10491.9 KII74391.1 - 2e-85 285.8 0.0 3.6e-85 285.0 0.0 1.4 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 DGCR6 PF07324.11 KII74393.1 - 0.0069 16.0 14.2 0.012 15.3 12.3 1.8 1 1 1 2 2 2 1 DiGeorge syndrome critical region 6 (DGCR6) protein zf-CRD PF17979.1 KII74393.1 - 0.25 11.4 1.7 0.34 11.0 1.7 1.2 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions Peptidase_U57 PF05582.12 KII74393.1 - 0.43 9.8 6.3 0.46 9.7 6.3 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Baculo_gp64 PF03273.13 KII74393.1 - 0.48 9.2 3.7 0.55 9.0 3.7 1.0 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family APG6_N PF17675.1 KII74393.1 - 0.74 10.4 8.8 1.1 9.9 8.8 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region GPS2_interact PF15784.5 KII74393.1 - 4.2 7.9 10.8 1.2 9.6 1.9 2.5 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain RasGEF PF00617.19 KII74394.1 - 1.5e-41 142.5 0.7 1.5e-41 142.5 0.7 1.9 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 KII74394.1 - 7e-09 35.9 0.3 4e-08 33.4 0.3 2.4 1 0 0 1 1 1 1 RasGEF N-terminal motif DEAD PF00270.29 KII74395.1 - 2.8e-42 144.4 0.0 5.2e-42 143.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KII74395.1 - 1.9e-31 108.7 0.1 5.5e-31 107.2 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KII74395.1 - 0.006 16.6 0.0 0.021 14.8 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KII74395.1 - 0.026 13.7 0.1 0.12 11.6 0.0 1.9 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase PI31_Prot_N PF11566.8 KII74395.1 - 0.76 9.6 4.2 0.5 10.1 1.7 2.0 2 0 0 2 2 2 0 PI31 proteasome regulator N-terminal NARP1 PF12569.8 KII74396.1 - 1.1e-40 140.0 14.0 1.2e-40 139.9 8.3 3.1 2 1 1 3 3 3 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 KII74396.1 - 1.5e-08 34.1 12.2 0.0034 17.4 0.0 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 KII74396.1 - 0.00051 20.3 0.0 36 4.8 0.0 5.0 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KII74396.1 - 0.0024 18.3 0.4 3.9 8.0 0.0 4.5 4 1 1 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KII74396.1 - 0.019 15.2 7.8 0.06 13.6 1.0 4.5 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KII74396.1 - 0.021 14.8 0.2 3.9 7.7 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KII74396.1 - 0.091 13.6 0.0 90 4.3 0.0 5.0 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 KII74396.1 - 0.11 12.2 0.1 4.7 7.0 0.1 3.6 4 0 0 4 4 4 0 TPR repeat Fis1_TPR_C PF14853.6 KII74396.1 - 0.32 11.1 10.4 33 4.7 0.0 5.4 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 KII74396.1 - 0.97 9.8 11.4 15 6.1 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII74396.1 - 5.4 7.0 22.7 3.8 7.5 0.2 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat Ldl_recept_a PF00057.18 KII74399.1 - 2.3e-37 126.9 101.3 4.3e-10 39.6 10.7 6.8 5 1 1 6 6 6 6 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 KII74399.1 - 9.3e-05 22.6 4.5 9.3e-05 22.6 4.5 5.5 5 2 0 5 5 5 1 Coagulation Factor Xa inhibitory site Pep3_Vps18 PF05131.14 KII74400.1 - 0.0083 15.9 0.6 1.3 8.8 0.0 2.3 1 1 1 2 2 2 2 Pep3/Vps18/deep orange family Sortilin_C PF15901.5 KII74401.1 - 6.6e-07 29.8 0.9 7.6e-07 29.6 0.9 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal RT_RNaseH_2 PF17919.1 KII74403.1 - 6e-31 106.4 0.0 1.3e-30 105.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74403.1 - 3.9e-29 101.7 0.0 7.9e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII74403.1 - 6e-28 97.2 0.0 1.4e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII74403.1 - 2.1e-22 79.6 0.0 4.5e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74403.1 - 3e-14 52.9 0.1 8.9e-14 51.3 0.1 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain zf-CCHC PF00098.23 KII74403.1 - 0.00081 19.4 2.0 0.0018 18.2 2.0 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.10 KII74403.1 - 0.023 14.9 0.0 0.33 11.2 0.0 2.8 2 0 0 2 2 2 0 H2C2 zinc finger rve_3 PF13683.6 KII74403.1 - 0.026 14.3 0.0 0.076 12.8 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_IS240 PF13610.6 KII74403.1 - 0.041 14.1 0.1 0.73 10.1 0.0 2.6 2 0 0 2 2 2 0 DDE domain HTH_23 PF13384.6 KII74406.1 - 1.1e-08 34.6 0.0 2.1e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 KII74406.1 - 3.6e-06 27.0 0.0 1.1e-05 25.5 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 KII74406.1 - 4.4e-06 26.6 0.0 5.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.6 KII74406.1 - 0.00044 20.0 0.1 0.0011 18.7 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII74406.1 - 0.0017 18.3 0.0 0.0019 18.1 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Crp_2 PF13545.6 KII74406.1 - 0.0062 16.5 0.1 0.015 15.2 0.0 1.6 1 1 1 2 2 2 1 Crp-like helix-turn-helix domain TrmB PF01978.19 KII74406.1 - 0.022 14.7 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 KII74406.1 - 0.031 14.2 0.4 0.2 11.6 0.4 2.0 1 1 0 1 1 1 0 MarR family HTH_7 PF02796.15 KII74406.1 - 0.056 13.5 0.6 0.11 12.5 0.1 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Sigma70_r4 PF04545.16 KII74406.1 - 0.098 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_11 PF08279.12 KII74406.1 - 0.1 12.5 0.2 0.15 12.0 0.2 1.3 1 0 0 1 1 1 0 HTH domain Sigma70_r4_2 PF08281.12 KII74406.1 - 0.11 12.2 0.1 0.21 11.3 0.0 1.5 2 0 0 2 2 2 0 Sigma-70, region 4 GerE PF00196.19 KII74406.1 - 0.13 11.9 0.2 0.2 11.3 0.2 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family SAT PF16073.5 KII74406.1 - 0.16 11.6 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Bacteroid_pep PF14406.6 KII74407.1 - 0.038 14.4 0.1 0.13 12.6 0.1 1.9 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Bacteroidetes RT_RNaseH_2 PF17919.1 KII74410.1 - 5.1e-15 55.3 0.8 2.7e-12 46.6 0.8 3.0 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74410.1 - 6e-14 52.2 0.4 4e-12 46.4 0.2 2.6 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 KII74410.1 - 3.5e-11 43.0 0.1 1.2e-10 41.3 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII74410.1 - 0.1 12.9 1.6 0.33 11.2 0.1 2.6 3 0 0 3 3 3 0 H2C2 zinc finger Bacillus_HBL PF05791.11 KII74413.1 - 5.8e-05 23.0 0.1 6.9e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) EC042_2821 PF18740.1 KII74413.1 - 0.053 13.4 3.1 0.049 13.5 2.0 1.5 1 1 0 1 1 1 0 EC042_2821-lke REase Nab1 PF04902.12 KII74413.1 - 0.074 13.5 0.0 0.087 13.2 0.0 1.1 1 0 0 1 1 1 0 Conserved region in Nab1 DDE_3 PF13358.6 KII74414.1 - 0.00044 20.0 0.0 0.00065 19.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Ldl_recept_a PF00057.18 KII74417.1 - 5.5e-21 74.5 50.5 1.1e-09 38.3 16.5 3.1 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Pneumo_phosprot PF02478.16 KII74417.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Pneumovirus phosphoprotein IgaA PF07095.11 KII74417.1 - 0.18 9.7 0.9 0.25 9.3 0.9 1.1 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA Vps62 PF06101.11 KII74419.1 - 0.062 11.6 0.0 0.066 11.5 0.0 1.0 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 62 SOG2 PF10428.9 KII74422.1 - 0.17 11.0 18.9 0.18 10.9 18.9 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Hamartin PF04388.12 KII74422.1 - 1.2 7.7 16.9 1.3 7.5 16.9 1.0 1 0 0 1 1 1 0 Hamartin protein DUF936 PF06075.12 KII74422.1 - 1.4 7.8 16.6 1.6 7.5 16.6 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) SMYLE_N PF18615.1 KII74422.1 - 2.3 7.7 9.2 3.7 7.0 9.2 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF966 PF06136.13 KII74422.1 - 2.5 7.7 15.0 2.9 7.5 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Presenilin PF01080.17 KII74422.1 - 4.1 6.1 9.2 5.1 5.8 9.2 1.3 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 KII74423.1 - 0.4 9.5 8.4 0.54 9.1 8.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MFS_1 PF07690.16 KII74426.1 - 6.5e-35 120.7 26.5 7.7e-34 117.2 23.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_5_2 PF16079.5 KII74426.1 - 8.3 6.8 14.4 3.6 8.0 0.3 4.2 3 1 0 4 4 4 0 Phage holin family Hol44, in holin superfamily V DUF3377 PF11857.8 KII74427.1 - 0.039 13.9 0.0 0.09 12.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) RIFIN PF02009.16 KII74427.1 - 4.2 7.2 8.1 0.6 10.0 2.8 1.9 2 1 0 2 2 2 0 Rifin FLYWCH PF04500.16 KII74433.1 - 2.2e-12 46.9 0.7 4e-12 46.0 0.2 1.8 2 0 0 2 2 2 1 FLYWCH zinc finger domain MULE PF10551.9 KII74433.1 - 6.7e-11 42.5 0.0 1.4e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain DUF948 PF06103.11 KII74434.1 - 0.0025 18.1 1.1 0.0045 17.2 0.0 2.0 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) DUF4883 PF16224.5 KII74434.1 - 0.017 15.4 1.8 0.017 15.4 1.8 3.0 3 1 1 4 4 4 0 DOmain of unknown function (DUF4883) DUF4200 PF13863.6 KII74434.1 - 0.033 14.6 4.9 0.077 13.4 4.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF745 PF05335.13 KII74434.1 - 0.23 11.2 2.7 0.97 9.1 2.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Prefoldin PF02996.17 KII74434.1 - 0.49 10.3 3.9 0.32 10.9 1.7 1.8 2 0 0 2 2 2 0 Prefoldin subunit PagP PF07017.11 KII74436.1 - 7.1e-55 184.4 8.4 1.4e-53 180.2 8.4 2.0 1 1 0 1 1 1 1 Antimicrobial peptide resistance and lipid A acylation protein PagP LysR_substrate PF03466.20 KII74437.1 - 8.9e-08 31.7 0.0 1e-07 31.5 0.0 1.0 1 0 0 1 1 1 1 LysR substrate binding domain Pkinase PF00069.25 KII74438.1 - 9.1e-35 120.3 0.0 1.2e-34 119.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII74438.1 - 4.5e-15 55.6 0.0 1e-14 54.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KII74438.1 - 0.15 11.7 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pur_ac_phosph_N PF16656.5 KII74439.1 - 2.4e-12 47.2 0.1 4.1e-12 46.5 0.1 1.3 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PDR_assoc PF08370.11 KII74439.1 - 0.048 13.4 0.1 0.096 12.4 0.1 1.5 1 0 0 1 1 1 0 Plant PDR ABC transporter associated MJ1316 PF04457.12 KII74439.1 - 0.078 13.7 0.0 0.14 12.9 0.0 1.3 1 0 0 1 1 1 0 MJ1316 RNA cyclic group end recognition domain DnaT PF17948.1 KII74439.1 - 0.11 12.2 0.3 0.2 11.4 0.3 1.4 1 0 0 1 1 1 0 DnaT DNA-binding domain Metallophos_C PF14008.6 KII74440.1 - 2.3e-11 44.4 0.0 3.5e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C CrgA PF06781.12 KII74441.1 - 0.041 14.0 3.0 0.057 13.5 0.1 3.0 2 0 0 2 2 2 0 Cell division protein CrgA Kelch_3 PF13415.6 KII74443.1 - 0.018 15.3 0.1 0.1 12.9 0.0 2.0 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 KII74443.1 - 0.093 13.1 0.5 0.17 12.3 0.2 1.7 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 KII74443.1 - 0.12 12.4 1.4 2.8 8.0 0.0 2.7 2 1 0 2 2 2 0 Galactose oxidase, central domain AT_hook PF02178.19 KII74444.1 - 0.094 12.6 4.0 0.097 12.6 1.4 2.2 2 0 0 2 2 2 0 AT hook motif Kelch_6 PF13964.6 KII74445.1 - 2.6e-05 24.3 2.7 0.0031 17.7 0.3 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII74445.1 - 0.0011 18.9 1.3 0.037 14.0 0.6 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 KII74445.1 - 0.43 10.2 3.9 5.6 6.6 0.5 2.5 2 1 0 2 2 2 0 Kelch motif zf-H2C2_2 PF13465.6 KII74449.1 - 4.9e-13 48.8 24.5 2.2e-09 37.3 1.3 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 KII74449.1 - 1.1e-11 44.6 23.6 0.00011 22.4 0.5 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII74449.1 - 3e-08 33.8 19.4 0.017 15.9 0.2 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KII74449.1 - 0.0018 18.0 1.4 0.0018 18.0 1.4 3.1 3 1 0 3 3 3 1 C2H2-type zinc-finger domain zf-LYAR PF08790.11 KII74449.1 - 0.0035 17.2 3.1 0.0035 17.2 3.1 2.5 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger LIM PF00412.22 KII74449.1 - 0.49 10.6 11.3 0.63 10.3 2.6 2.9 1 1 2 3 3 3 0 LIM domain zinc_ribbon_15 PF17032.5 KII74449.1 - 0.86 10.4 8.5 1.4 9.8 1.2 2.7 1 1 1 2 2 2 0 zinc-ribbon family zf-C2H2_jaz PF12171.8 KII74449.1 - 2.6 8.4 11.8 0.94 9.8 2.7 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KII74449.1 - 9.5 6.8 9.1 13 6.3 2.3 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type RTP PF02334.16 KII74454.1 - 0.053 14.2 0.2 0.13 12.9 0.1 1.6 1 1 0 1 1 1 0 Replication terminator protein Rad9 PF04139.13 KII74456.1 - 0.032 13.7 0.1 0.068 12.6 0.0 1.4 2 0 0 2 2 2 0 Rad9 Ribosomal_L27_C PF18471.1 KII74457.1 - 0.021 14.2 0.2 0.025 14.0 0.2 1.1 1 0 0 1 1 1 0 Ribosomal L27 protein C-terminal domain Hira PF07569.11 KII74458.1 - 2.2e-21 76.6 0.0 8.5e-21 74.7 0.0 2.0 1 1 0 1 1 1 1 TUP1-like enhancer of split HIRA_B PF09453.10 KII74458.1 - 4.1e-06 26.5 0.4 4.1e-06 26.5 0.4 2.2 2 0 0 2 2 2 1 HIRA B motif Suf PF05843.14 KII74458.1 - 9.1 6.2 9.6 0.53 10.2 0.5 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DDE_3 PF13358.6 KII74460.1 - 6.3e-06 26.0 0.1 1.5e-05 24.7 0.1 1.6 1 1 1 2 2 2 1 DDE superfamily endonuclease IF4E PF01652.18 KII74462.1 - 1.6e-35 122.2 0.3 2e-35 122.0 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF2748 PF10871.8 KII74463.1 - 0.074 11.7 3.1 0.29 9.7 3.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2748) Lactamase_B_2 PF12706.7 KII74463.1 - 0.095 12.2 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Beta-lactamase superfamily domain PH PF00169.29 KII74464.1 - 9.5e-17 61.4 0.2 1.1e-16 61.2 0.2 1.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KII74464.1 - 8.1e-05 23.0 0.3 0.00044 20.6 0.3 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 KII74464.1 - 0.1 12.9 0.0 0.16 12.3 0.0 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain TetR_C_29 PF17938.1 KII74466.1 - 0.071 13.2 0.1 0.096 12.8 0.1 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 KII74467.1 - 2.9e-05 24.7 1.3 0.013 16.3 0.4 3.2 2 0 0 2 2 2 2 WD domain, G-beta repeat PH_BEACH PF14844.6 KII74467.1 - 0.012 15.7 0.2 0.056 13.5 0.2 2.2 1 0 0 1 1 1 0 PH domain associated with Beige/BEACH Ribosomal_S8 PF00410.19 KII74468.1 - 6.7e-23 81.0 0.0 8.8e-23 80.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 YjcQ PF09639.10 KII74468.1 - 0.094 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 YjcQ protein Hfq PF17209.3 KII74469.1 - 0.092 12.4 1.7 2.3 7.9 0.2 2.7 3 0 0 3 3 3 0 Hfq protein Metallophos PF00149.28 KII74470.1 - 5.5e-12 46.6 0.0 7.6e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RVT_1 PF00078.27 KII74471.1 - 0.027 14.0 0.3 0.045 13.2 0.1 1.5 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) PALP PF00291.25 KII74472.1 - 2.4e-29 102.7 0.0 3e-29 102.4 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Usher PF00577.20 KII74473.1 - 2.7e-186 620.7 17.7 4e-186 620.1 17.7 1.2 1 0 0 1 1 1 1 Outer membrane usher protein PapC_N PF13954.6 KII74473.1 - 6.8e-27 94.3 0.0 1.4e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 PapC N-terminal domain PapD_N PF00345.20 KII74474.1 - 1.4e-42 144.5 0.0 2.1e-42 143.9 0.0 1.3 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain PapD_C PF02753.17 KII74474.1 - 4.9e-16 58.8 1.8 7.8e-16 58.2 0.6 2.0 2 0 0 2 2 2 1 Pili assembly chaperone PapD, C-terminal domain ASH PF15780.5 KII74474.1 - 0.07 13.3 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Fimbrial PF00419.20 KII74475.1 - 3.2e-18 66.4 8.4 3.9e-18 66.2 8.4 1.1 1 0 0 1 1 1 1 Fimbrial protein FimA PF16970.5 KII74475.1 - 0.01 16.0 8.8 0.65 10.2 8.8 2.4 1 1 0 1 1 1 0 Type-1 fimbrial protein, A Ribonuc_L-PSP PF01042.21 KII74476.1 - 3.8e-08 33.4 0.0 4.2e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Trans_reg_C PF00486.28 KII74477.1 - 5.8e-10 39.1 0.0 1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal MG3 PF17791.1 KII74478.1 - 0.022 15.0 0.1 0.055 13.7 0.0 1.6 1 1 1 2 2 2 0 Macroglobulin domain MG3 GerE PF00196.19 KII74479.1 - 2.9e-06 26.7 0.2 4.8e-06 26.0 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family dCMP_cyt_deam_1 PF00383.23 KII74480.1 - 9.3e-20 70.4 0.0 1.9e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KII74480.1 - 2.3e-19 69.5 0.2 4.8e-19 68.5 0.1 1.6 2 0 0 2 2 2 1 MafB19-like deaminase PHP PF02811.19 KII74481.1 - 5.2e-06 26.9 0.0 5.2e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 PHP domain DHDPS PF00701.22 KII74481.1 - 0.11 11.2 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Abhydrolase_3 PF07859.13 KII74482.1 - 3.7e-38 131.5 0.0 4.7e-27 95.2 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 KII74482.1 - 2.2e-09 36.7 0.0 3.8e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 KII74482.1 - 0.048 12.9 0.0 0.66 9.2 0.0 2.1 1 1 1 2 2 2 0 Serine aminopeptidase, S33 DUF554 PF04474.12 KII74483.1 - 2.6e-65 220.0 23.1 3e-65 219.8 23.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF554) ATPase_gene1 PF09527.10 KII74483.1 - 0.043 14.0 0.8 0.043 14.0 0.8 3.6 4 0 0 4 4 4 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter CLTH PF10607.9 KII74484.1 - 9.2e-05 22.4 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Proteasome PF00227.26 KII74488.1 - 2.1e-42 144.7 1.2 2.5e-42 144.5 1.2 1.0 1 0 0 1 1 1 1 Proteasome subunit SIS PF01380.22 KII74489.1 - 3.4e-41 140.2 0.4 2.5e-25 88.8 0.0 2.2 2 0 0 2 2 2 2 SIS domain SIS_2 PF13580.6 KII74489.1 - 0.01 15.8 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 0 SIS domain SIS PF01380.22 KII74490.1 - 0.0023 17.8 0.0 0.0029 17.4 0.0 1.1 1 0 0 1 1 1 1 SIS domain SIS PF01380.22 KII74491.1 - 3.5e-13 49.6 0.0 3.9e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 KII74491.1 - 0.0017 18.3 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 SIS domain DUF4942 PF13708.6 KII74491.1 - 0.032 14.2 0.2 0.056 13.4 0.2 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4942) UBA PF00627.31 KII74492.1 - 7.4e-11 41.7 0.2 1.9e-10 40.5 0.2 1.7 1 0 0 1 1 1 1 UBA/TS-N domain ubiquitin PF00240.23 KII74492.1 - 2.1e-07 30.6 0.0 4.9e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_5 PF18037.1 KII74492.1 - 0.00031 21.0 0.0 0.00057 20.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KII74492.1 - 0.0019 18.3 0.0 0.0046 17.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 KII74492.1 - 0.063 13.8 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Arif-1 PF06770.11 KII74494.1 - 0.045 13.4 0.1 0.053 13.2 0.1 1.0 1 0 0 1 1 1 0 Actin-rearrangement-inducing factor (Arif-1) OGG_N PF07934.12 KII74494.1 - 0.073 13.2 0.0 0.099 12.7 0.0 1.2 1 0 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain zf-CpG_bind_C PF12269.8 KII74495.1 - 4.7e-34 118.2 6.3 6.4e-34 117.8 6.3 1.1 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain Nup84_Nup100 PF04121.13 KII74496.1 - 0.17 10.0 0.0 0.18 9.9 0.0 1.0 1 0 0 1 1 1 0 Nuclear pore protein 84 / 107 Hexapep PF00132.24 KII74498.1 - 2e-06 27.3 10.6 0.018 14.7 1.7 4.4 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 KII74498.1 - 0.097 11.6 3.0 0.45 9.4 3.0 1.9 1 1 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 KII74498.1 - 1.6 8.5 8.9 1.4 8.8 1.0 3.3 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase Urm1 PF09138.11 KII74499.1 - 0.066 13.6 0.1 0.087 13.2 0.1 1.2 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) Dymeclin PF09742.9 KII74500.1 - 7.5e-09 34.6 0.3 8.2e-09 34.4 0.3 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 KII74500.1 - 2.3e-05 22.8 0.1 2.6e-05 22.6 0.1 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 KII74501.1 - 0.0019 16.7 5.3 0.0021 16.6 5.3 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein RteC PF09357.10 KII74501.1 - 0.0096 15.6 0.2 0.016 14.9 0.1 1.3 1 1 0 1 1 1 1 RteC protein Pallilysin PF18663.1 KII74502.1 - 0.0024 17.9 0.3 0.0032 17.4 0.3 1.2 1 0 0 1 1 1 1 Pallilysin beta barrel domain HTH_Tnp_IS630 PF01710.16 KII74502.1 - 0.004 17.2 0.0 0.0049 16.9 0.0 1.2 1 0 0 1 1 1 1 Transposase CENP-B_N PF04218.13 KII74502.1 - 0.02 14.5 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_ISL3 PF13542.6 KII74502.1 - 0.026 13.9 0.1 0.036 13.5 0.1 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Bot1p PF12298.8 KII74502.1 - 0.095 12.9 0.1 0.11 12.6 0.1 1.3 1 1 0 1 1 1 0 Eukaryotic mitochondrial regulator protein HTH_29 PF13551.6 KII74502.1 - 0.095 12.7 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_4 PF13613.6 KII74502.1 - 0.14 11.9 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Annexin PF00191.20 KII74505.1 - 1.2e-05 25.3 4.3 0.065 13.3 0.1 2.3 2 0 0 2 2 2 2 Annexin zf-UBR PF02207.20 KII74506.1 - 3.8e-10 39.8 17.4 3.8e-10 39.8 17.4 2.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) DUF4488 PF14869.6 KII74508.1 - 0.75 9.7 4.6 0.36 10.7 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4488) Serpin PF00079.20 KII74510.1 - 6.9e-28 98.0 0.8 3e-24 86.0 0.3 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) CDC45 PF02724.14 KII74510.1 - 0.089 11.1 9.5 0.11 10.8 9.5 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 KII74510.1 - 0.96 8.8 21.8 1.3 8.4 21.8 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 KII74510.1 - 6.5 4.8 22.6 9 4.4 22.6 1.1 1 0 0 1 1 1 0 Nop14-like family DDE_Tnp_IS1595 PF12762.7 KII74513.1 - 9.1e-19 68.0 0.0 1.4e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_ribbon_recom PF13408.6 KII74513.1 - 0.096 13.2 6.4 0.28 11.7 6.4 1.7 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain DDE_1 PF03184.19 KII74514.1 - 4.4e-05 23.2 0.0 5.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease RVP PF00077.20 KII74515.1 - 0.0097 16.2 0.0 0.028 14.7 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KII74515.1 - 0.0099 16.4 0.0 0.075 13.6 0.0 2.4 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease zf-UBR PF02207.20 KII74517.1 - 5.7e-14 52.0 14.7 5.7e-14 52.0 14.7 2.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Pkinase PF00069.25 KII74521.1 - 3.3e-37 128.3 0.1 4e-37 128.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII74521.1 - 4.6e-13 49.1 0.0 1e-12 47.9 0.0 1.5 1 1 1 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 KII74521.1 - 2.4e-05 23.5 0.2 4e-05 22.8 0.2 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 KII74521.1 - 0.0025 17.2 0.0 0.011 15.1 0.0 1.9 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KII74521.1 - 0.0053 16.7 0.0 0.008 16.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KII74521.1 - 0.14 10.9 0.1 0.21 10.3 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase zf-UBR PF02207.20 KII74522.1 - 1.5e-13 50.7 23.6 3e-13 49.7 23.6 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Axin_b-cat_bind PF08833.10 KII74522.1 - 0.056 13.6 0.1 0.13 12.4 0.1 1.6 1 0 0 1 1 1 0 Axin beta-catenin binding domain PurA PF04845.13 KII74523.1 - 0.00028 20.3 0.0 0.0004 19.8 0.0 1.2 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein FKBP_N PF01346.18 KII74524.1 - 6.3e-07 30.3 0.7 6.3e-07 30.3 0.7 1.6 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase UCH PF00443.29 KII74524.1 - 0.028 13.9 0.1 0.034 13.6 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase GerE PF00196.19 KII74525.1 - 3.5e-12 45.7 0.1 5e-10 38.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory proteins, luxR family FaeA PF04703.12 KII74525.1 - 9.2e-05 22.7 0.1 0.00024 21.4 0.0 1.7 2 0 0 2 2 2 1 FaeA-like protein Sigma70_r4_2 PF08281.12 KII74525.1 - 0.0022 17.6 0.5 1.6 8.5 0.1 3.0 3 0 0 3 3 3 2 Sigma-70, region 4 HTH_10 PF04967.12 KII74525.1 - 0.094 12.5 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 HTH DNA binding domain HTH_Mga PF08280.11 KII74525.1 - 0.18 11.9 1.1 6.2 6.9 0.0 2.8 2 1 1 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain DDE_Tnp_IS1595 PF12762.7 KII74526.1 - 6.9e-06 26.1 0.0 1.1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain ECSCR PF15820.5 KII74528.1 - 0.00082 19.2 0.2 0.0013 18.5 0.2 1.4 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator TMEM154 PF15102.6 KII74528.1 - 0.0019 18.1 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 KII74528.1 - 0.0049 17.2 0.1 0.0084 16.4 0.1 1.4 1 0 0 1 1 1 1 Orf78 (ac78) EphA2_TM PF14575.6 KII74528.1 - 0.011 16.6 0.1 2 9.3 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 KII74528.1 - 0.015 15.2 0.1 0.016 15.1 0.1 1.1 1 0 0 1 1 1 0 Rifin EVI2A PF05399.11 KII74528.1 - 0.019 14.5 0.1 0.032 13.8 0.1 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) T4SS_CagC PF16943.5 KII74528.1 - 0.038 14.2 0.2 0.072 13.3 0.2 1.4 1 0 0 1 1 1 0 Cag pathogenicity island, type IV secretory system ETRAMP PF09716.10 KII74528.1 - 0.048 13.7 0.2 0.081 13.0 0.2 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Baculo_11_kDa PF06143.11 KII74528.1 - 0.048 13.2 0.5 0.048 13.2 0.5 1.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family AMA-1 PF02430.15 KII74528.1 - 0.11 11.5 0.3 0.38 9.6 0.1 1.8 2 0 0 2 2 2 0 Apical membrane antigen 1 Shisa PF13908.6 KII74528.1 - 0.15 12.3 0.6 0.18 12.1 0.0 1.5 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Sigma_reg_N PF13800.6 KII74528.1 - 0.38 11.1 3.0 0.9 9.9 0.3 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal EFG_II PF14492.6 KII74531.1 - 4e-07 30.0 0.1 9.9e-07 28.8 0.1 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KII74531.1 - 3.2e-06 27.1 0.0 8e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KII74531.1 - 1.1e-05 25.7 0.0 2.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 KII74531.1 - 0.045 13.5 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 Elongation factor G, domain IV Rad17 PF03215.15 KII74531.1 - 0.058 13.3 0.2 0.12 12.3 0.2 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain GTP_EFTU PF00009.27 KII74532.1 - 2.4e-38 131.6 0.0 2.7e-38 131.5 0.0 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KII74532.1 - 0.044 13.9 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase NRD1_2 PF01995.16 KII74532.1 - 0.15 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 NrpR regulatory domains NRD1 and 2 Ins_P5_2-kin PF06090.12 KII74533.1 - 2.5e-43 148.8 0.3 3.2e-43 148.4 0.3 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Pkinase PF00069.25 KII74534.1 - 4.6e-05 22.9 0.0 6.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII74534.1 - 0.007 15.7 0.0 0.027 13.7 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Activin_recp PF01064.23 KII74535.1 - 0.00016 22.7 1.7 0.00022 22.3 1.7 1.2 1 0 0 1 1 1 1 Activin types I and II receptor domain FAT PF02259.23 KII74537.1 - 1.9e-65 221.3 1.0 1.9e-65 221.3 1.0 2.2 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.27 KII74537.1 - 2.6e-55 188.0 0.1 6e-55 186.8 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 KII74537.1 - 2.4e-24 86.1 7.4 7.3e-24 84.5 0.1 4.4 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 KII74537.1 - 4.5e-23 81.5 3.5 8.1e-23 80.7 0.8 2.9 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain FATC PF02260.20 KII74537.1 - 2.6e-13 49.5 1.6 6.3e-13 48.3 0.3 2.5 2 0 0 2 2 2 1 FATC domain HEAT_2 PF13646.6 KII74537.1 - 1.7e-05 25.1 0.0 4.5 7.7 0.0 4.3 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 KII74537.1 - 3.2e-05 23.8 0.2 40 4.8 0.0 5.4 4 0 0 4 4 4 0 HEAT repeat TPR_19 PF14559.6 KII74537.1 - 0.0095 16.4 0.6 8.4 7.0 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Cohesin_HEAT PF12765.7 KII74537.1 - 0.031 14.6 0.0 1.6 9.1 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion TAN PF11640.8 KII74537.1 - 0.048 13.8 3.6 0.3 11.2 0.0 4.0 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair Helicase_C PF00271.31 KII74538.1 - 5.6e-21 75.0 0.6 4.3e-17 62.5 0.1 3.9 4 0 0 4 4 4 2 Helicase conserved C-terminal domain DEAD PF00270.29 KII74538.1 - 9.6e-16 58.0 0.0 4.4e-15 55.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase DDE_Tnp_IS1595 PF12762.7 KII74541.1 - 4.7e-08 33.2 0.0 8.7e-08 32.3 0.0 1.5 1 1 1 2 2 2 1 ISXO2-like transposase domain DDE_Tnp_IS1595 PF12762.7 KII74542.1 - 2e-09 37.6 0.1 5.6e-09 36.2 0.0 1.6 1 1 1 2 2 2 1 ISXO2-like transposase domain GDI PF00996.18 KII74543.1 - 1.2e-169 564.4 0.3 1.5e-169 564.1 0.3 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor TBCC PF07986.12 KII74544.1 - 2.8e-13 49.6 2.0 3.6e-13 49.3 1.0 1.7 2 0 0 2 2 2 1 Tubulin binding cofactor C YniB PF14002.6 KII74544.1 - 0.069 12.9 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 YniB-like protein CREPT PF16566.5 KII74544.1 - 0.088 13.0 0.2 0.14 12.3 0.2 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Apolipoprotein PF01442.18 KII74545.1 - 0.012 15.5 0.0 0.036 13.9 0.0 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Syntaxin-6_N PF09177.11 KII74545.1 - 0.016 15.8 0.3 0.057 14.0 0.3 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF3461 PF11944.8 KII74545.1 - 0.017 15.2 2.7 0.067 13.3 2.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) HIP1_clath_bdg PF16515.5 KII74545.1 - 0.019 15.6 1.8 1.1 9.9 0.2 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 LXG PF04740.12 KII74545.1 - 0.022 14.5 2.8 1.6 8.4 0.1 2.0 1 1 1 2 2 2 0 LXG domain of WXG superfamily PRKG1_interact PF15898.5 KII74545.1 - 0.08 13.9 0.5 0.13 13.2 0.5 1.3 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain KxDL PF10241.9 KII74545.1 - 0.17 12.2 1.6 1 9.7 0.4 2.2 2 1 0 2 2 2 0 Uncharacterized conserved protein TMF_DNA_bd PF12329.8 KII74546.1 - 0.85 9.7 4.8 0.64 10.0 0.7 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF2516 PF10724.9 KII74547.1 - 0.041 14.2 0.2 0.05 13.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2516) SP_C-Propep PF08999.10 KII74547.1 - 0.051 13.4 0.2 0.072 12.9 0.2 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide rve PF00665.26 KII74549.1 - 5.8e-11 42.6 0.0 6.7e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain Tcp10_C PF07202.13 KII74550.1 - 0.00096 19.2 1.3 0.0011 18.9 1.3 1.1 1 0 0 1 1 1 1 T-complex protein 10 C-terminus SelR PF01641.18 KII74550.1 - 0.0094 16.0 1.2 0.041 14.0 0.3 2.2 2 1 0 2 2 2 1 SelR domain Integrase_H2C2 PF17921.1 KII74551.1 - 2.3e-08 34.0 0.0 3.3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII74551.1 - 0.018 15.3 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger TMF_DNA_bd PF12329.8 KII74553.1 - 0.0015 18.4 5.5 0.0015 18.4 5.5 4.9 3 1 2 5 5 5 2 TATA element modulatory factor 1 DNA binding Lebercilin PF15619.6 KII74553.1 - 0.0047 16.6 14.3 0.0047 16.6 14.3 2.6 2 1 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Filament PF00038.21 KII74553.1 - 0.0056 16.3 8.6 0.0056 16.3 8.6 3.7 1 1 3 4 4 4 3 Intermediate filament protein HIP1_clath_bdg PF16515.5 KII74553.1 - 0.018 15.6 29.1 0.98 10.1 10.4 4.2 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1664 PF07889.12 KII74553.1 - 0.018 15.0 20.6 0.73 9.9 0.9 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 KII74553.1 - 0.021 15.0 8.7 0.021 15.0 8.7 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family TMF_TATA_bd PF12325.8 KII74553.1 - 0.022 15.0 35.5 0.14 12.4 3.8 4.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 KII74553.1 - 0.025 14.3 1.9 0.025 14.3 1.9 5.8 3 2 3 6 6 6 0 Septum formation initiator NPV_P10 PF05531.12 KII74553.1 - 0.066 13.7 12.0 1.1 9.8 3.3 3.8 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 KII74553.1 - 0.083 13.5 22.4 0.73 10.5 1.0 5.6 2 2 2 5 5 5 0 SlyX Bap31_Bap29_C PF18035.1 KII74553.1 - 0.12 12.4 30.7 0.94 9.5 2.6 5.1 4 1 1 5 5 5 0 Bap31/Bap29 cytoplasmic coiled-coil domain Fez1 PF06818.15 KII74553.1 - 0.13 12.7 34.9 0.3 11.5 13.3 3.0 1 1 2 3 3 3 0 Fez1 DUF2203 PF09969.9 KII74553.1 - 0.14 12.9 19.2 0.045 14.5 1.9 3.4 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF5082 PF16888.5 KII74553.1 - 0.24 11.7 29.8 0.2 11.9 3.1 4.1 3 1 0 4 4 4 0 Domain of unknown function (DUF5082) DUF641 PF04859.12 KII74553.1 - 0.27 11.6 28.4 0.09 13.1 3.3 3.6 2 2 1 3 3 3 0 Plant protein of unknown function (DUF641) DUF16 PF01519.16 KII74553.1 - 0.33 11.4 26.3 1.5 9.4 4.7 3.6 2 1 1 3 3 3 0 Protein of unknown function DUF16 LPP PF04728.13 KII74553.1 - 0.34 11.3 9.0 16 6.0 0.7 4.4 3 1 0 3 3 3 0 Lipoprotein leucine-zipper DUF4407 PF14362.6 KII74553.1 - 0.45 9.8 21.4 2.5 7.4 12.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF812 PF05667.11 KII74553.1 - 0.46 9.3 41.6 1.9e+02 0.7 41.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF4763 PF15960.5 KII74553.1 - 0.97 8.7 26.2 2.2 7.5 5.9 3.7 1 1 1 3 3 3 0 Domain of unknown function (DUF4763) ATG16 PF08614.11 KII74553.1 - 1 9.6 36.0 1.6 8.9 13.6 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Phage_GP20 PF06810.11 KII74553.1 - 1.1 9.1 35.4 0.079 12.8 12.2 3.6 1 1 1 3 3 3 0 Phage minor structural protein GP20 COMP PF11598.8 KII74553.1 - 1.3 9.5 4.5 13 6.3 0.8 2.9 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein Golgin_A5 PF09787.9 KII74553.1 - 1.5 8.2 38.2 0.18 11.3 12.5 2.8 1 1 3 4 4 4 0 Golgin subfamily A member 5 Spc7 PF08317.11 KII74553.1 - 2 7.2 42.1 0.47 9.3 16.7 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein CC2-LZ PF16516.5 KII74553.1 - 2.1 8.8 33.3 4.4 7.7 9.8 4.3 2 1 2 4 4 4 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Rab_bind PF16704.5 KII74553.1 - 2.4 8.2 12.9 0.048 13.7 3.6 3.0 3 2 0 3 3 3 0 Rab binding domain XLF PF09302.11 KII74553.1 - 2.6 8.2 20.0 1.4 9.1 3.1 4.1 1 1 2 3 3 3 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component ERM PF00769.19 KII74553.1 - 2.9 7.6 35.2 0.39 10.5 10.6 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family IFT57 PF10498.9 KII74553.1 - 3 6.7 36.6 1.9 7.4 23.8 2.3 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Leu_zip PF15294.6 KII74553.1 - 3.8 6.9 38.5 3.3 7.2 16.6 2.7 1 1 1 2 2 2 0 Leucine zipper AKNA PF12443.8 KII74553.1 - 4.4 8.0 21.6 2.3 8.9 1.8 4.4 2 1 1 3 3 3 0 AT-hook-containing transcription factor BLOC1_2 PF10046.9 KII74553.1 - 6.7 7.1 29.2 0.5 10.7 3.3 4.7 3 1 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-H PF05837.12 KII74553.1 - 8 6.9 33.8 13 6.2 7.9 4.1 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF4055 PF13264.6 KII74553.1 - 8.2 6.6 9.0 7.8 6.7 0.2 3.4 1 1 2 4 4 4 0 Domain of unknown function (DUF4055) Med9 PF07544.13 KII74553.1 - 9.1 6.5 29.0 0.37 10.9 4.9 4.1 2 2 3 5 5 5 0 RNA polymerase II transcription mediator complex subunit 9 FHA PF00498.26 KII74556.1 - 4.3e-09 36.6 0.0 8.4e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain DDE_Tnp_IS1595 PF12762.7 KII74557.1 - 6.9e-05 22.9 0.0 0.00015 21.8 0.0 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain MFS_5 PF05631.14 KII74558.1 - 1.4e-16 60.4 12.5 3.1e-14 52.7 1.5 2.7 3 0 0 3 3 3 2 Sugar-tranasporters, 12 TM Ras PF00071.22 KII74559.1 - 3.9e-15 55.8 0.0 5.5e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Ras family MRP-S23 PF10484.9 KII74559.1 - 0.039 14.2 0.0 0.041 14.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S23 RsgA_GTPase PF03193.16 KII74559.1 - 0.046 13.6 0.0 0.056 13.4 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase DDE_3 PF13358.6 KII74561.1 - 2.1e-18 66.5 0.0 2.3e-18 66.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII74561.1 - 0.11 12.1 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease Fe_hyd_lg_C PF02906.14 KII74562.1 - 1.2e-51 175.8 0.0 1.6e-51 175.3 0.0 1.1 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Rer1 PF03248.13 KII74563.1 - 6.3e-62 208.3 12.5 7.3e-62 208.1 12.5 1.0 1 0 0 1 1 1 1 Rer1 family Toxin_36 PF10550.9 KII74566.1 - 0.26 12.7 0.5 0.67 11.4 0.2 1.9 1 1 0 1 1 1 0 Conantokin-G mollusc-toxin Pkinase PF00069.25 KII74567.1 - 3e-43 148.1 0.0 4.4e-43 147.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.12 KII74567.1 - 8.4e-30 103.6 1.9 1.4e-29 102.8 1.9 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 KII74567.1 - 3.3e-28 98.7 0.0 4.4e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KII74567.1 - 7.8e-06 24.9 0.0 2e-05 23.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase PQQ PF01011.21 KII74567.1 - 0.0029 17.5 0.4 0.013 15.4 0.1 2.2 2 0 0 2 2 2 1 PQQ enzyme repeat Kdo PF06293.14 KII74567.1 - 0.006 16.0 0.2 0.012 15.0 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KII74567.1 - 0.0084 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 KII74567.1 - 0.058 13.3 3.0 0.13 12.1 1.2 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family PQQ_2 PF13360.6 KII74567.1 - 0.14 11.7 0.0 0.37 10.3 0.0 1.6 2 0 0 2 2 2 0 PQQ-like domain DDE_1 PF03184.19 KII74568.1 - 3.5e-06 26.8 0.0 7.2e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KII74568.1 - 0.11 12.5 0.2 0.18 11.9 0.2 1.4 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 KII74569.1 - 0.055 13.2 0.0 0.094 12.5 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease V-ATPase_H_C PF11698.8 KII74569.1 - 0.056 13.5 0.1 0.17 12.0 0.0 1.7 1 1 1 2 2 2 0 V-ATPase subunit H ubiquitin PF00240.23 KII74570.1 - 5.1e-07 29.4 0.7 3.7e-06 26.6 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 KII74570.1 - 0.00016 21.4 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Uteroglobin PF01099.17 KII74570.1 - 0.0011 19.2 0.4 0.011 16.1 0.2 2.0 1 1 1 2 2 2 1 Uteroglobin family DUF2407 PF10302.9 KII74570.1 - 0.081 13.5 0.2 0.11 13.1 0.2 1.4 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Asparaginase_2 PF01112.18 KII74571.1 - 3.2e-47 161.0 1.5 4e-47 160.7 1.5 1.1 1 0 0 1 1 1 1 Asparaginase Colicin_V PF02674.16 KII74572.1 - 0.002 18.1 1.7 0.0031 17.5 1.7 1.2 1 0 0 1 1 1 1 Colicin V production protein DUF1600 PF07667.11 KII74572.1 - 0.019 15.1 7.0 0.045 14.0 7.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1600) DUF2207 PF09972.9 KII74572.1 - 0.057 12.2 3.4 0.083 11.6 3.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Strabismus PF06638.11 KII74572.1 - 0.12 11.0 4.0 0.17 10.5 4.0 1.2 1 0 0 1 1 1 0 Strabismus protein MULE PF10551.9 KII74573.1 - 2.5e-06 27.8 0.0 6.4e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 MULE transposase domain CENP-F_leu_zip PF10473.9 KII74574.1 - 0.00018 21.6 30.4 0.00024 21.1 15.3 14.0 2 2 12 14 14 14 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 KII74574.1 - 0.00056 18.9 15.5 0.00056 18.9 15.5 11.3 2 2 9 11 11 11 5 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 KII74574.1 - 0.00087 19.5 8.9 0.00087 19.5 8.9 17.2 5 2 13 19 19 19 4 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 KII74574.1 - 0.0012 18.9 3.8 0.0012 18.9 3.8 16.4 4 3 11 16 16 16 6 Protein of unknown function (DUF1664) GAS PF13851.6 KII74574.1 - 0.0012 18.2 26.7 0.0012 18.2 26.7 13.2 2 2 11 13 13 13 8 Growth-arrest specific micro-tubule binding RE_LlaJI PF09563.10 KII74575.1 - 0.0044 16.2 0.2 0.0051 16.0 0.2 1.0 1 0 0 1 1 1 1 LlaJI restriction endonuclease RVT_1 PF00078.27 KII74577.1 - 4.8e-22 78.6 0.7 1.2e-21 77.2 0.0 2.1 3 1 1 4 4 4 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 KII74577.1 - 5.2e-07 30.1 0.0 8.2e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII74577.1 - 2e-06 28.1 0.0 4e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KII74577.1 - 4.3e-05 24.1 0.0 7.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 KII74577.1 - 0.021 14.6 0.1 0.042 13.6 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 KII74577.1 - 0.021 14.9 3.8 0.042 13.9 3.8 1.5 1 0 0 1 1 1 0 Zinc knuckle Peptidase_A3 PF02160.15 KII74577.1 - 0.042 13.3 1.5 0.084 12.3 1.5 1.5 1 0 0 1 1 1 0 Cauliflower mosaic virus peptidase (A3) Y_phosphatase PF00102.27 KII74579.1 - 3.2e-67 226.5 5.5 4.1e-67 226.2 5.5 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KII74579.1 - 8.4e-05 22.7 0.1 0.00032 20.8 0.0 2.1 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KII74579.1 - 0.00024 21.1 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KII74579.1 - 0.0012 18.7 0.2 0.0077 16.0 0.1 2.4 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain MoCF_biosynth PF00994.24 KII74580.1 - 2.2e-08 33.9 0.0 3.5e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_C PF03454.15 KII74580.1 - 1.2e-05 25.4 0.0 1.9e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) TMEM154 PF15102.6 KII74582.1 - 0.00014 21.8 0.1 0.00022 21.1 0.1 1.3 1 0 0 1 1 1 1 TMEM154 protein family Ig_3 PF13927.6 KII74582.1 - 0.0021 18.6 0.0 0.0061 17.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KII74582.1 - 0.023 15.0 0.2 0.17 12.3 0.1 2.4 3 0 0 3 3 3 0 Immunoglobulin domain ABC_membrane PF00664.23 KII74582.1 - 0.04 13.6 0.2 0.072 12.7 0.2 1.3 1 0 0 1 1 1 0 ABC transporter transmembrane region Glycophorin_A PF01102.18 KII74582.1 - 0.056 13.7 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 Glycophorin A Ly49 PF08391.10 KII74582.1 - 0.062 13.7 0.1 0.17 12.3 0.1 1.7 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region I-set PF07679.16 KII74582.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain EphA2_TM PF14575.6 KII74582.1 - 0.12 13.3 0.0 0.22 12.4 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Herpes_gE PF02480.16 KII74582.1 - 0.14 10.9 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Mito_fiss_reg PF05308.11 KII74583.1 - 0.0032 17.6 6.4 0.0045 17.1 6.4 1.3 1 0 0 1 1 1 1 Mitochondrial fission regulator CAP_N PF01213.19 KII74583.1 - 0.25 10.8 8.8 0.34 10.3 8.8 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal UL42 PF17638.2 KII74583.1 - 1.5 8.8 6.1 2.9 7.9 6.1 1.5 1 0 0 1 1 1 0 HCMV UL42 HTH_23 PF13384.6 KII74584.1 - 1.7e-08 34.0 0.0 4.5e-06 26.3 0.0 2.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 KII74584.1 - 1.5e-05 25.5 0.1 0.00029 21.4 0.0 2.3 2 1 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 KII74584.1 - 4.9e-05 23.5 0.1 0.00013 22.1 0.1 1.8 2 0 0 2 2 1 1 Transposase HTH_33 PF13592.6 KII74584.1 - 6.9e-05 22.4 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_29 PF13551.6 KII74584.1 - 0.00012 22.0 0.0 0.00029 20.8 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 KII74584.1 - 0.00013 22.0 0.0 0.001 19.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain PAX PF00292.18 KII74584.1 - 0.00067 19.6 0.2 0.00095 19.1 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_3 PF01381.22 KII74584.1 - 0.0081 16.2 0.1 0.084 13.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix HTH_24 PF13412.6 KII74584.1 - 0.0081 15.7 0.2 3.1 7.4 0.0 2.4 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.16 KII74584.1 - 0.0095 15.4 0.2 0.082 12.4 0.0 2.1 2 0 0 2 2 2 1 Sigma-70, region 4 TrmB PF01978.19 KII74584.1 - 0.01 15.7 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_psq PF05225.16 KII74584.1 - 0.014 15.1 0.1 0.86 9.4 0.0 2.3 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_Tnp_ISL3 PF13542.6 KII74584.1 - 0.02 14.3 0.0 6.4 6.3 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Nuc_rec_co-act PF08815.10 KII74584.1 - 0.031 14.1 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 Nuclear receptor coactivator HTH_38 PF13936.6 KII74584.1 - 0.037 13.8 0.1 0.16 11.8 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain MarR_2 PF12802.7 KII74584.1 - 0.046 13.6 0.0 0.61 10.0 0.0 2.2 2 0 0 2 2 2 0 MarR family HTH_11 PF08279.12 KII74584.1 - 0.046 13.7 0.1 0.096 12.6 0.1 1.5 1 0 0 1 1 1 0 HTH domain HTH_50 PF18024.1 KII74584.1 - 0.046 13.3 0.0 7.7 6.2 0.0 2.8 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_17 PF12728.7 KII74584.1 - 0.064 13.5 0.1 20 5.5 0.0 2.6 3 0 0 3 3 2 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 KII74584.1 - 0.088 12.5 0.0 5.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_37 PF13744.6 KII74584.1 - 0.095 12.7 0.0 0.51 10.3 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain RuBisCO_small PF00101.20 KII74584.1 - 0.11 12.5 0.2 0.2 11.6 0.1 1.5 2 0 0 2 2 1 0 Ribulose bisphosphate carboxylase, small chain DUF4320 PF14208.6 KII74585.1 - 0.0023 18.0 0.0 0.0033 17.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4320) SPECT1 PF18680.1 KII74585.1 - 0.15 11.7 4.2 0.25 11.0 3.9 1.4 2 0 0 2 2 2 0 Plasmodium host cell traversal SPECT1 WH1 PF00568.23 KII74586.1 - 0.0087 16.0 0.5 0.023 14.6 0.2 1.8 1 1 1 2 2 2 1 WH1 domain DUF4665 PF15679.5 KII74586.1 - 0.015 15.9 3.5 0.017 15.7 2.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4665) TPKR_C2 PF16920.5 KII74587.1 - 0.11 12.7 0.1 0.3 11.2 0.1 1.8 1 0 0 1 1 1 0 Tyrosine-protein kinase receptor C2 Ig-like domain TPKR_C2 PF16920.5 KII74588.1 - 0.1 12.7 0.1 0.29 11.3 0.1 1.8 1 0 0 1 1 1 0 Tyrosine-protein kinase receptor C2 Ig-like domain DDE_3 PF13358.6 KII74589.1 - 5.1e-05 23.1 0.0 0.0001 22.1 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease PIF1 PF05970.14 KII74590.1 - 2.4e-07 30.3 0.1 3.3e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 PIF1-like helicase UvrD_C_2 PF13538.6 KII74590.1 - 0.00011 21.9 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 KII74590.1 - 0.00057 18.0 0.0 0.00076 17.5 0.0 1.1 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 KII74590.1 - 0.018 14.8 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF871 PF05913.11 KII74591.1 - 0.014 14.6 0.0 0.014 14.6 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF871) FAD_binding_2 PF00890.24 KII74593.1 - 7e-116 387.7 1.2 8.6e-116 387.4 1.2 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 KII74593.1 - 3.4e-37 127.3 0.1 5.3e-37 126.7 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 KII74593.1 - 0.0004 19.7 0.2 0.0011 18.2 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KII74593.1 - 0.00089 18.6 0.0 0.047 12.9 0.0 2.3 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 KII74593.1 - 0.0081 15.3 0.8 0.057 12.5 0.8 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.24 KII74593.1 - 0.09 12.3 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KII74593.1 - 0.098 11.9 0.1 0.18 11.0 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 KII74593.1 - 0.2 10.3 0.3 0.46 9.1 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein DDE_Tnp_IS1595 PF12762.7 KII74594.1 - 4.9e-12 46.1 0.1 1.1e-11 45.0 0.1 1.7 1 1 0 1 1 1 1 ISXO2-like transposase domain SPATA1_C PF15743.5 KII74594.1 - 0.0048 17.0 0.8 0.011 15.8 0.5 1.6 2 0 0 2 2 2 1 Spermatogenesis-associated C-terminus DDE_3 PF13358.6 KII74595.1 - 7.9e-29 100.3 0.0 1e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII74595.1 - 0.0013 18.9 0.0 0.0021 18.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-UBR PF02207.20 KII74596.1 - 1.4e-05 25.1 7.1 2.1e-05 24.6 7.1 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DDE_1 PF03184.19 KII74598.1 - 2.3e-15 56.7 0.4 1.7e-07 31.1 0.0 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease STN1_2 PF09170.10 KII74599.1 - 0.00055 20.2 0.1 0.00078 19.7 0.1 1.2 1 0 0 1 1 1 1 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Response_reg PF00072.24 KII74601.1 - 1.5e-27 96.0 0.1 2.4e-27 95.3 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 KII74601.1 - 2.4e-22 78.2 0.2 4e-22 77.5 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 KII74601.1 - 0.00017 21.2 0.0 0.00029 20.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_24 PF13412.6 KII74601.1 - 0.0016 17.9 0.1 0.0031 17.1 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.16 KII74601.1 - 0.0025 17.3 0.1 0.022 14.3 0.1 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 HisKA_3 PF07730.13 KII74602.1 - 6.5e-14 52.2 0.0 1.4e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase DUF2067 PF09840.9 KII74602.1 - 0.0031 17.1 0.3 0.0051 16.4 0.3 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2067) YmzC PF14157.6 KII74602.1 - 0.017 15.2 0.1 0.044 13.9 0.1 1.7 1 0 0 1 1 1 0 YmzC-like protein ABG_transport PF03806.13 KII74603.1 - 0.024 12.9 0.0 0.026 12.8 0.0 1.1 1 0 0 1 1 1 0 AbgT putative transporter family PMT_2 PF13231.6 KII74604.1 - 1.1e-08 35.5 12.0 1.1e-08 35.5 12.0 3.1 1 1 2 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2368 PF10166.9 KII74604.1 - 5.7 6.6 9.3 0.3 10.7 1.4 2.8 3 1 0 3 3 3 0 Uncharacterised conserved protein (DUF2368) Bac_transf PF02397.16 KII74605.1 - 2.8e-31 108.6 0.0 4.4e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial sugar transferase DnaA_N PF11638.8 KII74605.1 - 0.075 12.8 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 DnaA N-terminal domain PS_pyruv_trans PF04230.13 KII74606.1 - 3.5e-26 92.8 0.4 4.8e-26 92.3 0.4 1.1 1 0 0 1 1 1 1 Polysaccharide pyruvyl transferase Glycos_transf_2 PF00535.26 KII74607.1 - 1.8e-33 115.8 0.1 2.5e-33 115.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KII74607.1 - 1.7e-09 37.9 0.0 5.4e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KII74607.1 - 2.6e-08 33.7 0.3 5.6e-08 32.6 0.1 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KII74607.1 - 0.00017 22.0 0.1 0.0013 19.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 RILP PF11461.8 KII74607.1 - 0.0036 17.5 0.9 3.4 7.9 0.0 2.3 2 0 0 2 2 2 2 Rab interacting lysosomal protein Sde2_N_Ubi PF13019.6 KII74608.1 - 1.8e-20 73.4 1.9 2.6e-20 72.9 1.5 1.5 1 1 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain RhoGEF PF00621.20 KII74613.1 - 6.6e-12 46.0 3.5 6.6e-12 46.0 3.5 2.3 2 1 0 3 3 3 1 RhoGEF domain PH_13 PF16652.5 KII74613.1 - 0.00075 19.3 0.1 0.002 18.0 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain AAA PF00004.29 KII74615.1 - 2.7e-07 31.1 0.0 3.9e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KII74615.1 - 2.6e-05 24.7 0.1 9.2e-05 22.9 0.0 1.7 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 KII74615.1 - 3.3e-05 23.9 0.0 4.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 KII74615.1 - 0.00017 21.4 0.0 0.00021 21.1 0.0 1.1 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 KII74615.1 - 0.00037 20.3 0.0 0.00062 19.5 0.0 1.4 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 KII74615.1 - 0.0005 19.3 0.0 0.0006 19.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 KII74615.1 - 0.00055 20.0 0.0 0.0011 18.9 0.0 1.5 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 KII74615.1 - 0.00068 19.9 0.3 0.016 15.5 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KII74615.1 - 0.0013 18.8 0.0 0.0026 17.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KII74615.1 - 0.0024 17.5 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KII74615.1 - 0.0026 17.3 0.0 0.0033 16.9 0.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 KII74615.1 - 0.0033 17.8 0.0 0.0049 17.2 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KII74615.1 - 0.0037 17.1 0.0 0.0038 17.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 KII74615.1 - 0.0039 16.2 0.0 0.0095 14.9 0.0 1.6 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Mg_chelatase PF01078.21 KII74615.1 - 0.0048 16.3 0.0 0.0054 16.1 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KII74615.1 - 0.0096 15.7 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KII74615.1 - 0.013 16.1 0.0 0.017 15.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 KII74615.1 - 0.015 15.1 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KII74615.1 - 0.017 15.4 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 KII74615.1 - 0.018 14.8 0.0 0.59 9.9 0.0 2.0 1 1 1 2 2 2 0 DNA polymerase III, delta subunit SRP54 PF00448.22 KII74615.1 - 0.052 13.2 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 KII74615.1 - 0.059 13.8 0.0 0.085 13.3 0.0 1.3 1 0 0 1 1 1 0 RNA helicase T2SSE PF00437.20 KII74615.1 - 0.059 12.4 0.0 0.063 12.3 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein NTPase_1 PF03266.15 KII74615.1 - 0.07 13.0 0.2 0.14 12.0 0.1 1.6 1 1 0 1 1 1 0 NTPase cobW PF02492.19 KII74615.1 - 0.078 12.6 0.1 0.11 12.0 0.1 1.3 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KII74615.1 - 0.079 12.7 0.1 0.12 12.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 KII74615.1 - 0.099 12.0 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF2075 PF09848.9 KII74615.1 - 0.1 11.8 0.6 2.5 7.2 0.1 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) MipZ PF09140.11 KII74615.1 - 0.1 11.9 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 ATPase MipZ Zeta_toxin PF06414.12 KII74615.1 - 0.19 11.0 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 KII74615.1 - 0.19 12.2 0.1 0.47 11.0 0.0 1.6 1 1 1 2 2 2 0 ABC transporter Ribosomal_L27A PF00828.19 KII74618.1 - 9.6e-23 81.3 0.0 1.4e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Acetyltransf_1 PF00583.25 KII74619.1 - 9.3e-15 54.9 0.0 1.4e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KII74619.1 - 1.1e-07 31.8 0.0 1.7e-06 28.0 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KII74619.1 - 4.8e-07 30.1 0.1 8.2e-07 29.4 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KII74619.1 - 0.0033 17.5 0.0 0.19 11.8 0.1 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KII74619.1 - 0.084 12.9 0.0 0.41 10.6 0.0 1.9 1 1 1 2 2 2 0 FR47-like protein Acetyltransf_4 PF13420.7 KII74619.1 - 0.1 12.7 0.1 0.43 10.7 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain ATP-synt_ab PF00006.25 KII74621.1 - 6.8e-73 244.8 0.1 1.6e-72 243.6 0.0 1.7 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 KII74621.1 - 9.3e-46 155.2 0.5 1.7e-45 154.4 0.5 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 KII74621.1 - 2.2e-16 60.1 1.6 4.8e-16 59.0 1.6 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain BPL_LplA_LipB PF03099.19 KII74623.1 - 9.6e-14 51.4 0.0 2.3e-13 50.2 0.0 1.6 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family Ribosomal_L27e PF01777.18 KII74624.1 - 2.2e-26 92.0 10.9 2.1e-25 88.9 10.6 1.9 2 0 0 2 2 2 1 Ribosomal L27e protein family KOW PF00467.29 KII74624.1 - 0.00024 20.9 0.0 0.00069 19.5 0.0 1.7 1 0 0 1 1 1 1 KOW motif GATase PF00117.28 KII74625.1 - 2.2e-17 63.4 0.0 4.1e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 KII74625.1 - 1.6e-11 44.0 0.0 1.4e-07 31.5 0.0 2.8 2 0 0 2 2 2 2 GMP synthase C terminal domain Peptidase_C26 PF07722.13 KII74625.1 - 3.9e-05 23.5 0.0 6.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 KII74625.1 - 4.1e-05 22.8 0.0 0.034 13.3 0.0 2.3 2 0 0 2 2 2 2 NAD synthase QueC PF06508.13 KII74625.1 - 0.00081 18.9 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 KII74625.1 - 0.0068 16.0 0.0 0.027 14.0 0.0 2.0 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 KII74625.1 - 0.01 14.7 0.1 0.23 10.2 0.0 2.4 3 0 0 3 3 3 0 tRNA methyl transferase Asn_synthase PF00733.21 KII74625.1 - 0.038 13.7 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 Asparagine synthase DUF4147 PF13660.6 KII74625.1 - 0.11 12.1 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) bMG5 PF17972.1 KII74627.1 - 0.099 13.0 0.0 0.13 12.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG5 domain DnaJ PF00226.31 KII74628.1 - 0.065 13.4 0.5 4.3 7.5 0.0 3.0 3 0 0 3 3 3 0 DnaJ domain DUF2158 PF09926.9 KII74628.1 - 0.17 11.6 0.9 2.7 7.8 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized small protein (DUF2158) cNMP_binding PF00027.29 KII74629.1 - 1.6e-20 72.9 0.0 2.2e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RRM_1 PF00076.22 KII74630.1 - 6.4e-08 32.3 0.0 2e-07 30.7 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 KII74630.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated PHD PF00628.29 KII74631.1 - 0.036 14.0 9.2 0.071 13.0 9.2 1.5 1 0 0 1 1 1 0 PHD-finger Tudor_3 PF18115.1 KII74631.1 - 0.04 13.8 0.1 0.076 12.9 0.1 1.5 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain DUF4371 PF14291.6 KII74632.1 - 2e-12 47.3 0.1 2e-12 47.3 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) TFIID-18kDa PF02269.16 KII74633.1 - 3.9e-19 68.5 0.3 5.2e-19 68.1 0.3 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit NopRA1 PF16201.5 KII74635.1 - 6.7e-16 58.5 6.5 7.1e-16 58.4 3.6 2.8 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 BTB_2 PF02214.22 KII74636.1 - 3e-12 46.7 0.0 2.2e-11 43.9 0.0 2.2 1 1 0 1 1 1 1 BTB/POZ domain DUF2674 PF10879.8 KII74636.1 - 5.1e-06 25.9 0.2 1.8e-05 24.2 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2674) HORMA PF02301.18 KII74637.1 - 5.9e-18 65.2 4.5 2e-17 63.5 4.5 1.8 1 1 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 KII74637.1 - 7.9e-06 25.8 0.2 2.8e-05 24.1 0.1 1.9 2 0 0 2 2 2 1 Bacterial HORMA domain 2 PLA2_B PF01735.18 KII74637.1 - 0.085 11.3 0.5 0.1 10.9 0.5 1.0 1 0 0 1 1 1 0 Lysophospholipase catalytic domain TipAS PF07739.13 KII74637.1 - 0.15 12.6 0.1 1.7 9.2 0.1 2.1 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain DnaJ PF00226.31 KII74638.1 - 0.0007 19.7 0.1 0.041 14.0 0.0 2.3 2 0 0 2 2 2 2 DnaJ domain DER1 PF04511.15 KII74639.1 - 1.4e-48 165.3 16.3 1.7e-48 165.1 16.3 1.0 1 0 0 1 1 1 1 Der1-like family AMP-binding PF00501.28 KII74640.1 - 2.6e-73 247.0 0.0 3.4e-73 246.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PseudoU_synth_2 PF00849.22 KII74641.1 - 3.9e-08 33.5 0.0 5.9e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase AA_permease_2 PF13520.6 KII74643.1 - 5.9e-39 134.1 30.5 6.7e-39 133.9 30.5 1.0 1 0 0 1 1 1 1 Amino acid permease SH2 PF00017.24 KII74644.1 - 2.8e-14 52.9 0.5 6.2e-14 51.9 0.5 1.6 1 0 0 1 1 1 1 SH2 domain C1_1 PF00130.22 KII74644.1 - 4.4e-07 29.7 6.3 1.1e-06 28.4 6.3 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RhoGEF PF00621.20 KII74645.1 - 2.4e-15 57.2 6.4 2.4e-15 57.2 6.4 2.4 1 1 1 2 2 2 1 RhoGEF domain CDC24 PF06395.11 KII74645.1 - 5.3e-09 36.2 3.2 1.4e-08 34.8 0.1 2.9 3 0 0 3 3 3 1 CDC24 Calponin CH PF00307.31 KII74645.1 - 4.6e-08 33.2 2.2 1.2e-06 28.6 0.3 2.5 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KII74645.1 - 0.055 13.3 1.8 0.2 11.5 0.1 2.6 2 0 0 2 2 2 0 CAMSAP CH domain AF0941-like PF14591.6 KII74645.1 - 0.088 13.4 0.6 0.088 13.4 0.6 2.9 3 2 1 4 4 4 0 AF0941-like DUF1043 PF06295.12 KII74645.1 - 6.9 6.7 7.0 0.59 10.1 1.7 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) L51_S25_CI-B8 PF05047.16 KII74646.1 - 0.0029 17.5 0.4 0.0093 15.9 0.4 1.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain rve PF00665.26 KII74647.1 - 4e-25 88.3 0.0 6.8e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74647.1 - 0.0011 19.0 1.4 0.0027 17.8 1.4 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_Tnp_IS240 PF13610.6 KII74647.1 - 0.0028 17.9 0.1 0.0065 16.7 0.0 1.6 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.6 KII74647.1 - 0.0041 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII74647.1 - 0.078 13.1 0.0 0.26 11.4 0.0 1.9 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain PCI PF01399.27 KII74648.1 - 0.041 14.4 0.2 0.056 13.9 0.2 1.3 1 0 0 1 1 1 0 PCI domain PheRS_DBD1 PF18552.1 KII74648.1 - 0.13 12.0 0.0 0.44 10.3 0.0 1.8 2 0 0 2 2 2 0 PheRS DNA binding domain 1 Amidohydro_2 PF04909.14 KII74650.1 - 0.015 15.1 0.3 0.031 14.1 0.3 1.5 1 1 0 1 1 1 0 Amidohydrolase DUF2275 PF10039.9 KII74650.1 - 0.019 15.1 1.9 0.036 14.2 1.9 1.4 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2275) SfsA PF03749.13 KII74650.1 - 0.15 12.0 0.0 4.4 7.2 0.0 2.7 3 0 0 3 3 3 0 Sugar fermentation stimulation protein RE domain DDE_Tnp_IS1595 PF12762.7 KII74651.1 - 4.2e-13 49.6 0.1 5e-13 49.3 0.1 1.0 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_3 PF13358.6 KII74654.1 - 6.8e-13 48.6 0.2 7.2e-13 48.5 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease AMPK1_CBM PF16561.5 KII74654.1 - 0.039 14.2 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase Lipoprotein_8 PF02030.15 KII74656.1 - 0.052 12.3 0.1 0.061 12.0 0.1 1.0 1 0 0 1 1 1 0 Hypothetical lipoprotein (MG045 family) TrkA_N PF02254.18 KII74656.1 - 0.11 12.7 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain Serpin PF00079.20 KII74657.1 - 1.1e-35 123.6 6.3 1.3e-35 123.4 6.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Peptidase_S24 PF00717.23 KII74658.1 - 1.1e-09 38.2 2.0 4.1e-09 36.3 0.7 2.1 1 1 1 2 2 2 2 Peptidase S24-like Peptidase_S26 PF10502.9 KII74658.1 - 0.0097 15.7 0.1 0.11 12.3 0.0 2.0 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 DUF4438 PF14505.6 KII74658.1 - 0.084 11.8 0.0 0.088 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4438) DUF2463 PF09591.10 KII74659.1 - 0.0083 16.0 1.3 0.012 15.5 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2463) Phenyl_P_gamma PF09662.10 KII74660.1 - 0.016 15.3 0.1 0.041 14.0 0.1 1.6 1 1 0 1 1 1 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) DDE_3 PF13358.6 KII74661.1 - 1e-23 83.7 0.0 2.2e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII74661.1 - 0.0062 16.8 2.1 0.012 15.8 0.0 2.6 4 0 0 4 4 4 1 Transposase DDE_Tnp_ISAZ013 PF07592.11 KII74661.1 - 0.0074 15.3 0.3 0.82 8.6 0.1 2.3 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain Pro_3_hydrox_C PF05373.11 KII74661.1 - 0.047 13.8 0.6 0.3 11.2 0.1 2.3 2 0 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal HTH_23 PF13384.6 KII74661.1 - 0.14 12.0 0.1 1.6 8.6 0.1 2.3 2 0 0 2 2 2 0 Homeodomain-like domain IU_nuc_hydro PF01156.19 KII74662.1 - 8.5e-46 156.9 0.0 1e-45 156.6 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MRP-S23 PF10484.9 KII74664.1 - 0.05 13.9 0.7 0.11 12.8 0.7 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S23 PTPS PF01242.19 KII74664.1 - 0.078 13.0 1.8 0.2 11.6 0.5 2.2 1 1 1 2 2 2 0 6-pyruvoyl tetrahydropterin synthase Sortilin-Vps10 PF15902.5 KII74668.1 - 4.1e-13 48.9 0.2 6.2e-11 41.7 0.1 2.9 1 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII74668.1 - 2e-05 23.9 1.3 0.12 12.5 0.1 3.4 3 0 0 3 3 3 2 BNR/Asp-box repeat UPF0552 PF10574.9 KII74668.1 - 0.024 14.0 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Arp2/3-interacting proteins Arpin PQQ_2 PF13360.6 KII74668.1 - 0.053 13.1 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 PQQ-like domain SNAP PF14938.6 KII74671.1 - 0.0087 15.5 8.2 0.12 11.7 8.2 2.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Ank_4 PF13637.6 KII74671.1 - 0.14 12.8 0.0 0.36 11.5 0.0 1.7 2 0 0 2 2 2 0 Ankyrin repeats (many copies) NUP50 PF08911.11 KII74672.1 - 0.015 15.9 0.0 0.11 13.2 0.0 2.0 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) EGF_2 PF07974.13 KII74678.1 - 0.018 15.4 2.1 0.018 15.4 2.1 1.9 2 0 0 2 2 2 0 EGF-like domain MOR2-PAG1_N PF14222.6 KII74680.1 - 4.1e-23 82.2 6.3 4.6e-23 82.0 6.3 1.0 1 0 0 1 1 1 1 Cell morphogenesis N-terminal DUF1804 PF08822.11 KII74680.1 - 0.055 13.4 0.2 0.08 12.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) Tetraspanin PF00335.20 KII74686.1 - 4.2e-05 23.4 1.3 5.3e-05 23.0 1.3 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF2157 PF09925.9 KII74686.1 - 0.065 13.0 0.2 0.088 12.6 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) RT_RNaseH PF17917.1 KII74689.1 - 2.5e-40 137.0 0.0 5.8e-40 135.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74689.1 - 5.8e-36 122.5 0.0 1.5e-35 121.3 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74689.1 - 1.8e-30 106.1 0.1 3.8e-30 105.1 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII74689.1 - 9.3e-27 93.6 0.0 3.3e-26 91.8 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74689.1 - 2.2e-17 62.9 5.2 5.7e-17 61.6 2.5 2.8 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII74689.1 - 2.6e-06 27.9 0.0 6.3e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 KII74689.1 - 6.3e-06 26.0 0.5 1.3e-05 24.9 0.5 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII74689.1 - 2.3e-05 24.2 0.0 8.7e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.23 KII74689.1 - 0.00017 21.5 8.9 0.085 13.0 1.1 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-H2C2 PF09337.10 KII74689.1 - 0.0011 19.1 0.0 0.0082 16.3 0.0 2.5 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 KII74689.1 - 0.0027 17.4 0.0 0.0079 16.0 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 KII74689.1 - 0.017 15.2 0.0 0.051 13.7 0.0 1.8 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Asp_protease_2 PF13650.6 KII74689.1 - 0.023 15.4 0.0 0.054 14.1 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 KII74689.1 - 0.077 13.3 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_2 PF13696.6 KII74689.1 - 0.23 11.3 11.8 1.6 8.6 4.6 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII74689.1 - 0.31 10.8 6.8 1.6 8.5 0.7 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 KII74689.1 - 0.33 10.8 13.7 0.25 11.2 2.4 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 KII74689.1 - 0.44 10.5 13.5 57 3.8 13.5 2.7 1 1 0 1 1 1 0 Zinc knuckle SNAP PF14938.6 KII74690.1 - 2.2e-06 27.3 0.5 3.5e-06 26.7 0.3 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Trefoil PF00088.18 KII74690.1 - 1.1 9.2 5.4 0.41 10.6 2.3 1.9 2 0 0 2 2 2 0 Trefoil (P-type) domain HTH_Tnp_1 PF01527.20 KII74692.1 - 0.011 16.0 0.1 0.26 11.6 0.1 2.1 2 0 0 2 2 2 0 Transposase CpxA_peri PF16527.5 KII74692.1 - 0.1 12.9 1.9 0.12 12.8 1.9 1.1 1 0 0 1 1 1 0 Two-component sensor protein CpxA, periplasmic domain DDE_3 PF13358.6 KII74693.1 - 5.9e-31 107.2 0.0 7e-31 107.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.19 KII74693.1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII74693.1 - 0.004 17.3 0.0 0.0063 16.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII74695.1 - 8.7e-31 106.6 0.0 1.3e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 KII74695.1 - 6.5e-07 29.5 0.0 2.2e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 Transposase rve PF00665.26 KII74695.1 - 0.00041 20.5 0.0 0.0011 19.2 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain HTH_24 PF13412.6 KII74695.1 - 0.0078 15.8 0.5 0.72 9.5 0.0 2.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_33 PF13592.6 KII74695.1 - 0.051 13.2 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix HTH_32 PF13565.6 KII74695.1 - 0.064 13.9 0.0 1.3 9.7 0.0 2.5 1 1 1 2 2 2 0 Homeodomain-like domain CBM_3 PF00942.18 KII74696.1 - 0.16 12.4 2.7 0.19 12.2 0.6 2.1 2 0 0 2 2 2 0 Cellulose binding domain PRELI PF04707.14 KII74700.1 - 0.015 15.2 0.4 0.017 15.0 0.4 1.1 1 0 0 1 1 1 0 PRELI-like family Peptidase_C1 PF00112.23 KII74703.1 - 4.3e-35 121.8 0.7 5e-35 121.6 0.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Hemocyanin_M PF00372.19 KII74703.1 - 0.0072 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Hemocyanin, copper containing domain PLAC PF08686.11 KII74705.1 - 0.048 14.4 4.5 3.7 8.4 0.0 3.7 3 0 0 3 3 3 0 PLAC (protease and lacunin) domain Integrase_H2C2 PF17921.1 KII74707.1 - 1.8e-08 34.4 0.1 1.8e-08 34.4 0.1 1.8 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII74707.1 - 2.9e-05 24.2 0.0 0.031 14.4 0.0 2.9 2 1 1 3 3 3 2 Integrase core domain MFS_1 PF07690.16 KII74708.1 - 9.4e-28 97.1 21.8 6.5e-26 91.1 18.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KII74708.1 - 5.4e-10 38.7 5.8 5.4e-10 38.7 5.8 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter Herpes_LMP1 PF05297.11 KII74708.1 - 2 7.5 3.7 3.6 6.7 3.7 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) rve PF00665.26 KII74710.1 - 5.6e-20 71.7 0.0 8.8e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII74710.1 - 8.2e-06 25.5 0.0 1.9e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_3 PF13358.6 KII74710.1 - 0.0021 17.8 0.0 0.004 16.9 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Nepo_coat_N PF03689.15 KII74710.1 - 0.022 14.7 0.1 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Nop10p PF04135.12 KII74713.1 - 0.17 12.0 2.4 1 9.5 2.4 2.2 1 1 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family DUF4969 PF16339.5 KII74714.1 - 0.11 12.9 3.7 1 9.8 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4969) Sigma_reg_N PF13800.6 KII74714.1 - 0.89 9.9 5.6 0.19 12.0 1.7 1.9 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF4596 PF15363.6 KII74714.1 - 5.6 7.3 6.9 21 5.5 2.7 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4596) Methyltransf_28 PF02636.17 KII74715.1 - 6.1e-09 35.9 0.0 6.8e-09 35.7 0.0 1.0 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF3346 PF11826.8 KII74715.1 - 0.059 13.2 0.0 0.07 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3346) SET PF00856.28 KII74717.1 - 2.1e-14 54.3 0.0 6.6e-13 49.4 0.0 2.3 1 1 0 1 1 1 1 SET domain Ras PF00071.22 KII74718.1 - 1.2e-43 148.5 0.0 1.4e-43 148.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII74718.1 - 2.4e-24 85.9 0.0 3.9e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII74718.1 - 8e-10 38.4 0.0 9.7e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KII74718.1 - 2.9e-06 27.3 0.0 4e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KII74718.1 - 0.00038 20.1 0.0 0.011 15.3 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 KII74718.1 - 0.0004 20.2 0.0 0.81 9.4 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 KII74718.1 - 0.0027 17.6 0.0 0.0039 17.1 0.0 1.2 1 0 0 1 1 1 1 NTPase G-alpha PF00503.20 KII74718.1 - 0.016 14.4 0.8 0.022 13.9 0.4 1.4 1 1 1 2 2 2 0 G-protein alpha subunit DnaB_C PF03796.15 KII74718.1 - 0.032 13.6 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain RsgA_GTPase PF03193.16 KII74718.1 - 0.036 14.0 0.0 5.8 6.8 0.0 2.5 2 1 1 3 3 3 0 RsgA GTPase Gtr1_RagA PF04670.12 KII74718.1 - 0.049 13.0 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region TIP49 PF06068.13 KII74718.1 - 0.16 11.1 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_22 PF13401.6 KII74718.1 - 0.19 12.0 0.0 22 5.3 0.0 2.4 3 0 0 3 3 3 0 AAA domain zf-UBR PF02207.20 KII74719.1 - 7.5e-05 22.8 2.7 0.00013 22.1 2.7 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Tetraspanin PF00335.20 KII74722.1 - 9.2e-16 58.2 10.1 1.1e-15 58.0 10.1 1.1 1 0 0 1 1 1 1 Tetraspanin family RGI1 PF10843.8 KII74723.1 - 0.069 12.8 0.3 0.075 12.7 0.3 1.1 1 0 0 1 1 1 0 Respiratory growth induced protein 1 FCH PF00611.23 KII74724.1 - 0.014 15.6 0.1 0.016 15.5 0.1 1.2 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Adaptin_N PF01602.20 KII74725.1 - 3e-75 253.8 0.4 4e-75 253.4 0.5 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_g_Cpla PF16381.5 KII74725.1 - 1.4e-27 96.1 0.1 3.7e-27 94.7 0.1 1.8 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform COP-gamma_platf PF08752.10 KII74725.1 - 3.1e-19 69.6 0.0 6.6e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Cnd1 PF12717.7 KII74725.1 - 5.7e-12 46.0 0.2 0.0042 17.2 0.0 4.0 2 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KII74725.1 - 2.4e-08 34.3 0.0 0.00078 19.8 0.0 4.4 3 1 2 5 5 5 1 HEAT repeats Vac14_Fab1_bd PF12755.7 KII74725.1 - 0.00012 22.6 2.1 0.77 10.4 0.0 4.2 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 KII74725.1 - 0.0029 18.1 4.2 0.7 10.5 0.5 4.1 5 0 0 5 5 5 1 HEAT-like repeat HEAT PF02985.22 KII74725.1 - 0.0038 17.4 11.3 2.6 8.5 0.0 5.6 6 0 0 6 6 5 2 HEAT repeat B2-adapt-app_C PF09066.10 KII74725.1 - 0.0059 16.7 0.0 0.021 14.9 0.0 2.0 1 1 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain Coatomer_b_Cpla PF14806.6 KII74725.1 - 0.0095 15.9 0.1 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd3 PF12719.7 KII74725.1 - 0.039 13.2 0.3 0.38 9.9 0.1 2.6 1 1 1 2 2 2 0 Nuclear condensing complex subunits, C-term domain Ccdc124 PF06244.12 KII74726.1 - 1.3e-24 87.2 4.8 1.6e-24 86.9 4.8 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 YABBY PF04690.13 KII74726.1 - 5.8e-07 30.2 1.7 7.4e-07 29.9 1.7 1.2 1 0 0 1 1 1 1 YABBY protein HMG_box PF00505.19 KII74726.1 - 0.046 14.1 0.6 0.083 13.3 0.6 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box MULE PF10551.9 KII74727.1 - 2.2e-08 34.4 0.0 3.8e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 MULE transposase domain NDK PF00334.19 KII74728.1 - 1.3e-21 77.0 0.0 1.5e-21 76.8 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase MaAIMP_sms PF16951.5 KII74728.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative methionine and alanine importer, small subunit RNase_T PF00929.24 KII74729.1 - 3.3e-18 66.8 0.0 5e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 KII74729.1 - 0.0001 22.1 0.0 0.00026 20.8 0.0 1.7 2 1 0 2 2 2 1 3'-5' exonuclease tRNA_SAD PF07973.14 KII74730.1 - 5.1e-05 23.3 0.0 0.00013 22.0 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF5595 PF18077.1 KII74730.1 - 0.023 14.8 0.0 0.068 13.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) DUF1835 PF08874.10 KII74730.1 - 0.076 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1835) DUF1579 PF07617.11 KII74731.1 - 0.00069 19.6 0.3 6.1 6.8 0.0 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF1579) GDI PF00996.18 KII74732.1 - 1.2e-09 37.2 0.3 2.2e-09 36.4 0.3 1.3 1 1 0 1 1 1 1 GDP dissociation inhibitor TRAM1 PF08390.11 KII74733.1 - 0.00027 20.5 0.1 0.00078 19.1 0.1 1.9 1 0 0 1 1 1 1 TRAM1-like protein Serpin PF00079.20 KII74734.1 - 4.5e-72 243.4 3.5 5.3e-72 243.2 3.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII74735.1 - 4.3e-32 111.9 5.7 5.1e-32 111.6 5.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3969 PF13108.6 KII74735.1 - 0.013 15.5 0.1 0.022 14.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3969) ApoO PF09769.9 KII74736.1 - 0.85 9.6 2.7 2.9 7.8 1.2 1.9 1 1 1 2 2 2 0 Apolipoprotein O DUF2039 PF10217.9 KII74738.1 - 0.055 13.8 0.0 0.21 12.0 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) DDE_3 PF13358.6 KII74739.1 - 0.00026 20.8 0.1 0.0003 20.6 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Bac_chlorC PF02043.17 KII74739.1 - 0.057 13.4 0.1 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 Bacteriochlorophyll C binding protein RNase_H2_suC PF08615.11 KII74741.1 - 0.12 12.6 0.1 0.17 12.1 0.1 1.1 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) MLVIN_C PF18697.1 KII74744.1 - 0.0015 18.6 0.7 0.0042 17.1 0.1 1.9 2 0 0 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Sedlin_N PF04628.13 KII74744.1 - 0.036 14.2 0.5 0.12 12.5 0.3 1.8 2 0 0 2 2 2 0 Sedlin, N-terminal conserved region Streptin-Immun PF11083.8 KII74744.1 - 0.046 14.1 0.3 0.076 13.4 0.3 1.3 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein rve PF00665.26 KII74745.1 - 0.054 13.7 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain DUF4975 PF16346.5 KII74746.1 - 0.13 12.3 0.1 0.2 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) RT_RNaseH PF17917.1 KII74749.1 - 9.7e-32 109.4 0.0 1.7e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74749.1 - 1.3e-28 99.0 0.1 3.3e-28 97.6 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII74749.1 - 2e-18 66.7 0.0 4e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74749.1 - 2.8e-17 62.6 0.3 5.4e-17 61.6 0.3 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII74749.1 - 0.0019 17.9 0.1 0.0039 17.0 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain DUF995 PF06191.12 KII74751.1 - 0.14 11.9 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF995) Sortilin-Vps10 PF15902.5 KII74754.1 - 1.7e-06 27.1 0.3 2.8e-06 26.4 0.3 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Dynein_light PF01221.18 KII74755.1 - 7.2e-27 93.5 0.1 8.4e-27 93.3 0.1 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 MFS_1 PF07690.16 KII74758.1 - 2e-24 86.2 21.4 1.2e-23 83.6 18.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily YlaH PF14036.6 KII74758.1 - 0.072 13.4 1.2 0.37 11.2 1.2 2.3 1 0 0 1 1 1 0 YlaH-like protein DDE_Tnp_IS1595 PF12762.7 KII74759.1 - 1.1e-19 71.0 0.0 1.4e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain FeS_assembly_P PF01883.19 KII74760.1 - 1.1e-06 28.7 0.0 1.8e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein CM_1 PF07736.11 KII74762.1 - 0.055 13.9 0.0 0.84 10.0 0.0 2.1 1 1 1 2 2 2 0 Chorismate mutase type I EFG_II PF14492.6 KII74763.1 - 1.1e-25 89.5 0.1 1.5e-25 89.1 0.1 1.2 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 KII74763.1 - 3.6e-25 88.1 0.0 5.3e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor G, domain IV RF3_C PF16658.5 KII74763.1 - 7.1e-06 25.9 0.0 9.3e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MAGE PF01454.19 KII74763.1 - 0.024 14.3 0.1 0.034 13.9 0.1 1.2 1 0 0 1 1 1 0 MAGE family THUMP PF02926.17 KII74763.1 - 0.12 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 THUMP domain FG-GAP PF01839.23 KII74765.1 - 0.0056 16.8 0.5 0.0092 16.1 0.5 1.4 1 0 0 1 1 1 1 FG-GAP repeat Integrase_H2C2 PF17921.1 KII74766.1 - 1.2e-05 25.4 1.6 2.2e-05 24.5 1.6 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 KII74768.1 - 9.4e-18 64.1 0.0 1.6e-16 60.2 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74768.1 - 9e-12 45.2 0.1 1.5e-10 41.3 0.1 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Cnd2 PF05786.14 KII74769.1 - 2.2e-40 139.1 1.9 6.2e-26 91.3 0.1 2.6 3 0 0 3 3 3 2 Condensin complex subunit 2 Myb_DNA-bind_3 PF12776.7 KII74770.1 - 0.046 14.7 0.6 0.063 14.3 0.6 1.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF1939 PF09154.10 KII74774.1 - 0.13 12.5 0.3 0.88 9.8 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1939) RVT_1 PF00078.27 KII74776.1 - 0.00018 21.1 0.2 0.0003 20.4 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TraU PF06834.11 KII74776.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 TraU protein AIF_C PF14721.6 KII74777.1 - 0.044 14.1 0.0 0.048 14.0 0.0 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DinI PF06183.13 KII74778.1 - 2.9e-20 72.4 0.1 5.7e-20 71.4 0.1 1.5 1 0 0 1 1 1 1 DinI-like family RVT_1 PF00078.27 KII74779.1 - 5.3e-09 35.9 0.1 8.9e-09 35.2 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII74779.1 - 0.0002 21.6 1.4 0.14 12.5 0.0 3.2 3 1 1 4 4 4 2 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74779.1 - 0.0083 16.1 0.0 0.025 14.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase mCpol PF18182.1 KII74779.1 - 0.029 14.7 0.1 0.053 13.8 0.1 1.4 1 0 0 1 1 1 0 minimal CRISPR polymerase domain rve PF00665.26 KII74780.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Lyase_8 PF02278.18 KII74781.1 - 0.036 13.5 0.1 0.67 9.4 0.0 2.0 1 1 1 2 2 2 0 Polysaccharide lyase family 8, super-sandwich domain Sortilin-Vps10 PF15902.5 KII74782.1 - 2.2e-14 53.1 0.3 1.2e-13 50.7 0.2 1.8 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII74782.1 - 0.004 16.9 7.3 1.5 9.1 0.1 4.1 4 0 0 4 4 4 3 BNR/Asp-box repeat RVT_1 PF00078.27 KII74783.1 - 0.0014 18.2 0.0 0.0016 18.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sortilin-Vps10 PF15902.5 KII74784.1 - 4.3e-15 55.4 0.4 1.6e-13 50.3 0.3 1.9 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII74784.1 - 7.6e-15 55.7 0.6 2e-14 54.3 0.6 1.6 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII74784.1 - 0.0053 16.6 7.3 1.7 9.0 0.1 4.2 4 0 0 4 4 4 2 BNR/Asp-box repeat ORC2 PF04084.14 KII74784.1 - 0.1 11.5 1.1 0.45 9.4 0.5 1.9 2 0 0 2 2 2 0 Origin recognition complex subunit 2 FRG2 PF15315.6 KII74788.1 - 0.015 15.5 0.1 0.019 15.2 0.1 1.2 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 DUF16 PF01519.16 KII74788.1 - 0.091 13.3 1.0 0.32 11.5 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 zf-CCCH PF00642.24 KII74792.1 - 1.2e-07 31.4 25.7 2.7e-05 23.9 1.9 3.9 2 1 1 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KII74792.1 - 3.4e-07 30.1 34.4 2e-06 27.6 4.7 4.1 4 0 0 4 4 4 3 Zinc finger domain zf-CCCH_3 PF15663.5 KII74792.1 - 1.3e-05 25.4 13.1 0.00021 21.5 5.1 2.5 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 KII74792.1 - 6.6e-05 22.6 20.4 0.0002 21.1 1.9 4.5 4 0 0 4 4 4 2 CCCH-type zinc finger Torus PF16131.5 KII74792.1 - 0.0026 18.4 3.4 0.0026 18.4 3.4 3.4 1 1 2 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 KII74792.1 - 0.0048 17.3 3.3 0.0048 17.3 3.3 4.4 3 1 0 3 3 3 2 RNA-binding, Nab2-type zinc finger OST3_OST6 PF04756.13 KII74793.1 - 9.7e-39 133.5 7.6 1.2e-38 133.2 7.6 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF4131 PF13567.6 KII74793.1 - 0.63 9.7 5.1 1.7 8.3 0.3 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) VPS9 PF02204.18 KII74794.1 - 6.2e-25 87.4 0.7 9.2e-25 86.9 0.1 1.6 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain COG5 PF10392.9 KII74794.1 - 0.038 14.2 0.7 0.093 12.9 0.1 1.9 2 1 0 2 2 2 0 Golgi transport complex subunit 5 DDE_3 PF13358.6 KII74796.1 - 0.0035 17.1 0.0 0.0047 16.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease C12orf66_like PF09404.10 KII74799.1 - 0.057 12.3 0.0 0.063 12.1 0.0 1.1 1 0 0 1 1 1 0 KICSTOR complex C12orf66 like Tash_PEST PF07708.11 KII74802.1 - 0.088 13.0 3.1 0.088 13.0 3.1 1.7 2 0 0 2 2 2 0 Tash protein PEST motif RT_RNaseH_2 PF17919.1 KII74804.1 - 7.8e-37 125.3 0.1 1.6e-36 124.4 0.1 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74804.1 - 3e-36 123.9 0.0 8.9e-36 122.4 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74804.1 - 3.2e-21 75.9 0.0 5.5e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII74804.1 - 6.4e-17 61.4 1.3 1.5e-16 60.2 1.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KII74804.1 - 1.3e-12 48.0 0.0 3.3e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII74804.1 - 1.2e-07 31.8 0.0 3.6e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger zf-CCHC PF00098.23 KII74804.1 - 3e-05 23.9 11.3 0.016 15.3 2.1 2.6 2 0 0 2 2 2 2 Zinc knuckle gag-asp_proteas PF13975.6 KII74804.1 - 5.9e-05 23.6 0.0 0.00013 22.5 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII74804.1 - 0.026 14.8 0.0 0.095 13.0 0.0 2.0 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_4 PF14392.6 KII74804.1 - 0.036 13.8 7.6 1.6 8.5 0.6 3.0 1 1 1 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 KII74804.1 - 0.048 14.3 0.0 0.098 13.3 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Spuma_A9PTase PF03539.14 KII74804.1 - 0.054 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-CCHC_6 PF15288.6 KII74804.1 - 0.1 12.4 11.8 0.7 9.8 0.8 2.7 2 0 0 2 2 2 0 Zinc knuckle RVP_2 PF08284.11 KII74804.1 - 0.15 11.8 0.1 0.33 10.7 0.1 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease DDE_3 PF13358.6 KII74807.1 - 7.9e-29 100.3 0.0 1e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 KII74807.1 - 0.0013 18.9 0.0 0.0021 18.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain HeH PF12949.7 KII74811.1 - 0.13 11.9 0.0 0.52 10.1 0.0 2.0 2 0 0 2 2 2 0 HeH/LEM domain DUF4208 PF13907.6 KII74813.1 - 0.11 12.9 0.0 0.32 11.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) Vinculin PF01044.19 KII74816.1 - 3.9e-19 68.4 23.8 1.6e-18 66.5 23.8 2.0 1 1 0 1 1 1 1 Vinculin family Herpes_UL3 PF03369.13 KII74816.1 - 0.14 12.7 1.7 0.35 11.4 1.7 1.7 1 0 0 1 1 1 0 Herpesvirus UL3 protein LepB_N PF18640.1 KII74816.1 - 0.77 9.4 20.7 0.044 13.4 2.4 4.2 4 0 0 4 4 4 0 LepB N-terminal domain ApoO PF09769.9 KII74818.1 - 0.076 13.0 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Apolipoprotein O Sortilin_C PF15901.5 KII74821.1 - 2.3e-10 41.1 0.4 2.9e-10 40.7 0.4 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal RT_RNaseH PF17917.1 KII74824.1 - 0.0001 22.5 0.0 0.00014 22.1 0.0 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74824.1 - 0.0049 16.9 0.0 0.0069 16.4 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Porin_1 PF00267.21 KII74826.1 - 3.5e-67 227.2 13.0 4e-67 227.1 13.0 1.0 1 0 0 1 1 1 1 Gram-negative porin RT_RNaseH PF17917.1 KII74828.1 - 9.8e-17 61.2 0.4 1.3e-16 60.8 0.4 1.2 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74828.1 - 7.1e-09 35.6 0.2 1.3e-08 34.7 0.2 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 KII74828.1 - 0.024 14.4 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase-like zf-met PF12874.7 KII74829.1 - 0.026 14.9 2.9 3.4 8.2 0.7 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Laminin_N PF00055.17 KII74829.1 - 0.095 12.3 3.0 0.12 12.0 3.0 1.2 1 0 0 1 1 1 0 Laminin N-terminal (Domain VI) YdjO PF14169.6 KII74829.1 - 0.15 11.8 3.0 4.3 7.2 0.5 2.4 2 0 0 2 2 2 0 Cold-inducible protein YdjO zf-C2H2_4 PF13894.6 KII74829.1 - 0.32 11.9 7.5 4.3 8.5 0.5 2.6 2 1 0 2 2 2 0 C2H2-type zinc finger RVT_1 PF00078.27 KII74830.1 - 5.6e-07 29.3 0.0 6.2e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2_6 PF13912.6 KII74832.1 - 0.039 14.0 0.1 0.039 14.0 0.1 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 KII74832.1 - 0.16 12.9 2.5 3.7 8.6 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger RVT_1 PF00078.27 KII74833.1 - 6.1e-05 22.6 0.4 9.2e-05 22.0 0.4 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 KII74834.1 - 6.3e-11 42.2 0.0 1.3e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 KII74834.1 - 6e-06 26.1 9.8 0.0028 17.6 1.4 2.6 2 0 0 2 2 2 2 Zinc knuckle RVP PF00077.20 KII74834.1 - 9e-05 22.7 0.0 0.00026 21.3 0.0 1.8 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII74834.1 - 0.00013 21.8 0.0 0.00061 19.6 0.0 2.1 2 1 0 2 2 2 1 Aspartyl protease Asp_protease_2 PF13650.6 KII74834.1 - 0.013 16.2 0.0 0.023 15.3 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Spuma_A9PTase PF03539.14 KII74834.1 - 0.022 14.9 0.1 0.059 13.5 0.1 1.7 1 1 1 2 2 2 0 Spumavirus aspartic protease (A9) gag-asp_proteas PF13975.6 KII74834.1 - 0.032 14.8 0.0 0.067 13.8 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease zf-CCHC_3 PF13917.6 KII74834.1 - 0.16 12.0 11.7 0.3 11.1 2.1 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 KII74834.1 - 2.5 7.9 6.5 3.7 7.4 0.5 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 KII74834.1 - 4.7 7.1 9.6 0.13 12.1 2.7 2.0 2 0 0 2 2 2 0 Zinc knuckle rve PF00665.26 KII74835.1 - 7.6e-22 77.7 0.0 9e-22 77.5 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 KII74835.1 - 0.00064 19.5 0.1 0.0016 18.2 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain Transcript_VP30 PF11507.8 KII74835.1 - 0.16 12.0 0.0 0.37 10.9 0.0 1.5 1 1 0 1 1 1 0 Ebola virus-specific transcription factor VP30 MLVIN_C PF18697.1 KII74836.1 - 0.024 14.7 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain AT_hook PF02178.19 KII74836.1 - 0.98 9.5 7.8 2 8.6 7.8 1.6 1 0 0 1 1 1 0 AT hook motif RT_RNaseH_2 PF17919.1 KII74837.1 - 2e-31 108.0 0.0 4.6e-31 106.8 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74837.1 - 1.2e-28 99.5 0.0 2.7e-28 98.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74837.1 - 3e-28 98.9 0.0 5.2e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 KII74837.1 - 1.2e-14 54.1 0.9 1.2e-14 54.1 0.9 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII74837.1 - 0.00012 22.5 0.0 0.00029 21.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 KII74837.1 - 0.0054 17.0 0.0 0.019 15.2 0.0 2.0 1 0 0 1 1 1 1 Retroviral aspartyl protease rve PF00665.26 KII74837.1 - 0.013 15.7 0.0 0.071 13.3 0.0 2.3 2 0 0 2 2 2 0 Integrase core domain zf-H2C2 PF09337.10 KII74837.1 - 0.015 15.5 0.1 0.061 13.5 0.1 2.2 1 0 0 1 1 1 0 H2C2 zinc finger Asp_protease_2 PF13650.6 KII74837.1 - 0.026 15.2 0.0 0.06 14.0 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease DDE_3 PF13358.6 KII74838.1 - 9.8e-05 22.1 0.0 0.00011 22.0 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-C2H2_12 PF18658.1 KII74838.1 - 0.0089 15.6 1.3 0.03 13.9 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger C2H2-type RB_B PF01857.20 KII74838.1 - 0.017 15.2 0.9 0.026 14.5 0.4 1.5 1 1 1 2 2 2 0 Retinoblastoma-associated protein B domain RVT_1 PF00078.27 KII74843.1 - 4.5e-06 26.3 0.0 5.8e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1338 PF07063.13 KII74845.1 - 0.026 13.7 0.0 0.03 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1338) Urocanase PF01175.18 KII74845.1 - 0.049 13.3 0.1 0.062 12.9 0.1 1.1 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Kelch_1 PF01344.25 KII74848.1 - 3.6e-17 61.7 5.4 3e-07 29.9 0.5 3.1 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 KII74848.1 - 2.1e-16 59.5 7.6 5.7e-06 26.4 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII74848.1 - 6.4e-11 42.3 1.3 0.0034 17.6 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII74848.1 - 1.3e-09 37.9 3.9 0.0071 16.3 0.2 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII74848.1 - 8.7e-06 25.5 7.5 0.19 11.7 0.1 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII74848.1 - 0.0095 15.9 6.7 1.1 9.4 0.3 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII74849.1 - 0.00087 19.3 0.3 1.3 9.0 0.1 2.5 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 KII74849.1 - 0.015 15.6 0.0 0.68 10.3 0.0 2.4 2 1 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 KII74849.1 - 0.017 14.7 4.9 0.31 10.7 0.7 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 KII74849.1 - 1.3 9.4 3.9 17 5.8 0.7 2.5 1 1 0 2 2 2 0 Kelch motif Spermine_synth PF01564.17 KII74850.1 - 0.057 12.8 0.2 0.2 11.1 0.2 1.9 1 1 0 1 1 1 0 Spermine/spermidine synthase domain Kelch_6 PF13964.6 KII74852.1 - 2.5e-14 52.9 6.7 1.4e-07 31.5 0.1 3.4 3 1 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII74852.1 - 4.6e-14 51.7 4.8 0.0016 18.0 0.5 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII74852.1 - 3.5e-12 46.3 4.4 0.00015 22.0 0.1 4.0 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KII74852.1 - 1.3e-09 37.9 5.5 0.015 15.3 0.0 3.9 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII74852.1 - 5.2e-07 29.4 2.5 0.0052 16.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII74852.1 - 0.00015 21.6 2.3 0.84 9.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 KII74853.1 - 3.3e-05 23.4 1.1 0.11 12.1 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 KII74853.1 - 0.0023 17.8 1.2 0.18 11.8 0.5 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 KII74853.1 - 0.0037 17.5 0.5 2.2 8.7 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 KII74853.1 - 0.079 13.0 2.6 1.4 9.0 0.3 3.4 3 1 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 KII74853.1 - 0.16 12.0 4.2 1.2 9.2 1.1 2.5 1 1 1 2 2 2 0 Galactose oxidase, central domain Kelch_3 PF13415.6 KII74853.1 - 0.19 12.1 0.4 0.91 9.9 0.0 2.1 1 1 2 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 KII74855.1 - 1.7e-06 28.1 6.3 0.0021 18.3 0.4 3.5 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII74855.1 - 3.7e-05 23.9 0.2 0.075 13.4 0.0 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KII74855.1 - 0.00011 22.2 0.7 0.091 12.8 0.0 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KII74855.1 - 0.00047 20.1 4.2 0.065 13.2 0.7 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII74855.1 - 0.00096 19.0 4.0 0.059 13.4 0.1 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 KII74855.1 - 0.92 9.2 10.2 9.4 5.9 1.3 3.6 4 0 0 4 4 4 0 Kelch motif DDE_3 PF13358.6 KII74856.1 - 2.6e-15 56.5 0.0 2.8e-15 56.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Kelch_6 PF13964.6 KII74857.1 - 3.1e-14 52.6 10.8 0.029 14.7 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KII74857.1 - 2.1e-11 43.8 0.5 9.9e-05 22.5 0.1 5.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KII74857.1 - 4.5e-06 26.6 7.0 0.35 10.9 0.1 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII74857.1 - 0.00011 21.7 21.1 0.43 10.2 0.9 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 KII74857.1 - 0.065 13.2 0.4 0.065 13.2 0.4 4.8 6 0 0 6 6 6 0 Kelch motif rve PF00665.26 KII74858.1 - 3.5e-20 72.4 0.0 7.3e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74858.1 - 2.4e-15 56.4 0.2 5.5e-15 55.2 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII74858.1 - 0.0069 16.1 0.0 0.02 14.6 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Kelch_6 PF13964.6 KII74860.1 - 1e-15 57.4 2.3 1.8e-05 24.8 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII74860.1 - 7.1e-10 38.9 0.1 0.0035 17.6 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KII74860.1 - 7.6e-08 32.2 2.5 0.0042 17.0 0.1 3.1 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII74860.1 - 1.2e-07 31.2 15.9 5.5e-06 25.9 0.9 3.6 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII74860.1 - 5.5e-06 26.2 3.1 0.00014 21.7 0.1 2.8 3 1 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 KII74860.1 - 3.5e-05 23.6 1.9 0.1 12.6 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Atx10homo_assoc PF09759.9 KII74861.1 - 0.02 14.9 0.0 0.044 13.8 0.0 1.6 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Tho1_MOS11_C PF18592.1 KII74861.1 - 0.072 12.9 0.3 0.27 11.1 0.3 2.0 1 0 0 1 1 1 0 Tho1/MOS11 C-terminal domain GyrB_insert PF18053.1 KII74861.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain DUF1778 PF08681.11 KII74864.1 - 0.0063 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1778) DUF3950 PF13132.6 KII74864.1 - 0.14 11.9 1.8 0.19 11.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3950) Sulfate_transp PF00916.20 KII74865.1 - 2.3e-59 201.0 27.9 8.2e-30 103.8 4.9 2.2 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 KII74865.1 - 2.3e-11 43.3 0.1 3.9e-11 42.6 0.1 1.3 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 KII74865.1 - 0.00049 20.5 4.3 0.00049 20.5 4.3 4.1 4 0 0 4 4 4 2 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 KII74865.1 - 0.00055 20.2 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 STAS domain BmKX PF09132.10 KII74865.1 - 0.36 10.9 0.9 0.75 9.8 0.9 1.5 1 0 0 1 1 1 0 BmKX GGDEF PF00990.21 KII74866.1 - 8e-39 133.0 0.1 8.6e-39 132.9 0.1 1.0 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain DUF3095 PF11294.8 KII74866.1 - 0.0043 16.2 0.0 0.0055 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3095) DUF249 PF03158.13 KII74866.1 - 0.028 14.1 0.3 0.042 13.6 0.3 1.3 1 0 0 1 1 1 0 Multigene family 530 protein SIS PF01380.22 KII74867.1 - 5.3e-50 168.6 0.6 2.2e-29 101.9 0.1 2.5 2 0 0 2 2 2 2 SIS domain SIS_2 PF13580.6 KII74867.1 - 0.034 14.2 0.0 0.08 13.0 0.0 1.6 1 0 0 1 1 1 0 SIS domain Flot PF15975.5 KII74867.1 - 0.18 12.0 0.3 27 5.0 0.0 2.3 2 0 0 2 2 2 0 Flotillin Spermine_synth PF01564.17 KII74868.1 - 1.1e-65 220.6 0.3 2.7e-65 219.3 0.0 1.8 3 0 0 3 3 3 1 Spermine/spermidine synthase domain AdoMet_dc PF02675.15 KII74868.1 - 4.6e-30 104.0 0.0 1.2e-29 102.7 0.0 1.7 1 0 0 1 1 1 1 S-adenosylmethionine decarboxylase Spermine_synt_N PF17284.2 KII74868.1 - 2.4e-20 72.2 0.3 4.8e-20 71.2 0.3 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KII74868.1 - 1.2e-06 29.1 0.1 8.7e-06 26.4 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 KII74868.1 - 0.0005 20.7 0.0 0.0024 18.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KII74868.1 - 0.0017 18.1 0.1 0.005 16.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KII74868.1 - 0.0072 15.9 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain TraP PF07296.11 KII74868.1 - 0.093 11.9 0.2 0.68 9.1 0.0 2.1 2 0 0 2 2 2 0 TraP protein Methyltransf_12 PF08242.12 KII74868.1 - 0.099 13.4 0.0 0.43 11.3 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain DUF4874 PF16173.5 KII74869.1 - 0.061 13.0 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) Integrase_H2C2 PF17921.1 KII74872.1 - 6.5e-07 29.4 0.2 2.6e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 KII74872.1 - 0.00076 19.7 0.0 0.0013 18.9 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain DUF2532 PF10811.8 KII74873.1 - 0.043 13.9 3.2 0.07 13.2 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2532) Fib_alpha PF08702.10 KII74873.1 - 0.046 13.9 0.4 0.083 13.1 0.4 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FLYWCH PF04500.16 KII74874.1 - 7.2e-08 32.4 1.1 1.2e-07 31.7 1.1 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain WRKY PF03106.15 KII74874.1 - 0.12 12.6 1.2 0.25 11.6 1.2 1.5 1 0 0 1 1 1 0 WRKY DNA -binding domain DUF3330 PF11809.8 KII74875.1 - 0.0061 16.6 0.4 0.0088 16.1 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3330) Pox_E8 PF03394.13 KII74875.1 - 0.017 14.7 0.2 0.02 14.5 0.2 1.0 1 0 0 1 1 1 0 Poxvirus E8 protein Kelch_6 PF13964.6 KII74876.1 - 9.1e-05 22.6 9.0 0.02 15.2 0.5 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII74876.1 - 0.00021 21.2 9.4 0.019 14.9 2.4 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 KII74876.1 - 0.0014 18.9 5.5 0.035 14.4 0.0 3.3 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 KII74876.1 - 0.0033 17.4 11.1 0.043 13.8 0.3 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KII74876.1 - 0.008 15.7 10.0 0.4 10.3 0.5 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 KII74876.1 - 1.7 8.7 9.1 9.4 6.4 0.4 3.3 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 KII74877.1 - 1.3e-14 53.9 6.5 2.6e-06 27.5 0.2 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII74877.1 - 1e-05 25.4 0.8 0.0033 17.4 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 KII74877.1 - 3.2e-05 24.1 2.5 0.045 14.1 0.1 4.2 4 1 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII74877.1 - 8.5e-05 22.1 10.1 0.0008 18.9 0.0 4.1 3 2 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 KII74877.1 - 0.00012 22.0 11.6 0.0022 18.0 0.2 4.1 3 2 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KII74877.1 - 0.0098 15.8 8.4 0.037 14.0 1.0 3.5 3 2 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 KII74878.1 - 4e-12 46.0 2.4 6.1e-05 23.2 0.1 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 KII74878.1 - 3.4e-08 32.9 1.8 0.0014 18.2 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII74878.1 - 1.9e-07 31.2 1.2 0.043 14.1 0.0 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII74878.1 - 0.00035 20.4 0.6 2.8 8.0 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII74878.1 - 0.00047 20.1 0.7 0.13 12.2 0.0 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 KII74878.1 - 0.0011 18.9 5.3 0.43 10.6 0.2 4.1 3 2 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 KII74879.1 - 1.3e-16 59.9 10.1 1.6e-06 27.6 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 KII74879.1 - 1.1e-15 57.2 7.7 9.8e-07 28.9 0.4 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII74879.1 - 1.4e-11 44.2 6.0 0.0048 16.9 0.2 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KII74879.1 - 3.3e-11 43.2 8.9 0.0021 18.3 0.1 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII74879.1 - 1e-09 38.0 5.5 0.00021 21.1 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII74879.1 - 2.2e-09 37.1 8.3 2.8e-05 24.0 0.1 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 KII74880.1 - 2.6e-19 68.7 21.6 5e-05 23.4 0.0 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KII74880.1 - 7.8e-18 64.2 16.3 7.8e-05 22.6 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 KII74880.1 - 3.2e-15 55.4 23.5 0.00054 19.5 1.1 6.9 7 0 0 7 7 7 6 Kelch motif Kelch_5 PF13854.6 KII74880.1 - 1.1e-11 44.4 17.8 3e-05 23.9 0.0 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KII74880.1 - 2.3e-10 40.5 18.7 0.00041 20.6 1.2 6.6 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KII74880.1 - 3.6e-05 23.6 15.4 0.52 10.4 0.1 5.7 6 0 0 6 6 6 3 Kelch motif Glyco_transf_21 PF13506.6 KII74882.1 - 2.1e-10 40.3 0.0 2.9e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KII74882.1 - 4.3e-06 26.6 0.1 8.6e-06 25.7 0.1 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KII74882.1 - 6.8e-06 26.1 0.0 8.3e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DDE_Tnp_IS1595 PF12762.7 KII74884.1 - 1.1e-06 28.7 0.0 1.4e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain LCAT PF02450.15 KII74886.1 - 3.7e-45 154.8 0.4 1.3e-34 120.1 0.1 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 KII74886.1 - 4.1e-08 32.8 0.0 5.3e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KII74886.1 - 0.00031 21.4 0.0 0.00036 21.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 KII74886.1 - 0.00065 19.5 0.0 0.00091 19.0 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.11 KII74886.1 - 0.0093 15.3 0.2 0.034 13.5 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Hen1_L PF12623.7 KII74888.1 - 0.044 12.8 0.0 0.073 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA repair, ligase-Pnkp-associating, region of Hen1 Replic_Relax PF13814.6 KII74888.1 - 0.098 12.7 0.1 0.13 12.4 0.1 1.2 1 0 0 1 1 1 0 Replication-relaxation Cnd1 PF12717.7 KII74889.1 - 0.019 15.0 2.8 0.086 12.9 2.8 1.8 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Methyltrn_RNA_2 PF04013.12 KII74890.1 - 0.061 13.0 0.0 0.067 12.9 0.0 1.1 1 0 0 1 1 1 0 Putative SAM-dependent RNA methyltransferase Pkinase PF00069.25 KII74891.1 - 5.3e-49 167.0 0.2 1.1e-35 123.2 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KII74891.1 - 1.5e-27 96.6 0.1 6.3e-21 74.8 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase FRQ PF09421.10 KII74891.1 - 0.0052 14.9 0.2 0.0052 14.9 0.2 2.1 2 1 0 2 2 2 1 Frequency clock protein PQQ_2 PF13360.6 KII74891.1 - 0.0083 15.7 0.0 0.079 12.5 0.0 2.1 1 1 0 2 2 2 1 PQQ-like domain Kinase-like PF14531.6 KII74891.1 - 0.019 14.3 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 Kinase-like PQQ PF01011.21 KII74891.1 - 0.039 13.9 0.0 0.25 11.3 0.0 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat Sortilin-Vps10 PF15902.5 KII74894.1 - 5.4e-08 32.1 2.1 4.7e-07 29.0 2.1 2.0 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 KII74894.1 - 5.7e-05 22.5 2.6 0.56 10.4 0.0 4.2 4 0 0 4 4 4 3 BNR/Asp-box repeat DDE_3 PF13358.6 KII74895.1 - 3e-10 40.0 0.2 3.2e-10 39.9 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Gp_dh_N PF00044.24 KII74895.1 - 0.035 14.5 0.0 0.046 14.1 0.0 1.2 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Ldl_recept_a PF00057.18 KII74896.1 - 3.6e-08 33.5 8.0 3.6e-08 33.5 8.0 3.7 3 1 1 4 4 4 3 Low-density lipoprotein receptor domain class A Caudo_bapla_RBP PF08931.10 KII74896.1 - 0.02 14.3 0.1 0.029 13.8 0.1 1.1 1 0 0 1 1 1 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head Ribosomal_L7Ae PF01248.26 KII74898.1 - 6.2e-11 41.9 0.1 1.8e-10 40.4 0.0 1.7 1 1 1 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Vps52 PF04129.12 KII74899.1 - 7.2e-25 87.7 12.1 1.4e-24 86.7 12.1 1.4 1 0 0 1 1 1 1 Vps52 / Sac2 family Ldl_recept_a PF00057.18 KII74900.1 - 3.6e-06 27.1 14.2 3.6e-06 27.1 14.2 3.4 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A Atg8 PF02991.16 KII74902.1 - 1.7e-08 34.6 0.0 2e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Cyclin_N PF00134.23 KII74903.1 - 2e-30 105.1 1.1 1.1e-28 99.5 0.3 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 KII74903.1 - 7.3e-24 84.2 0.4 1.3e-23 83.3 0.4 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Methyltransf_FA PF12248.8 KII74903.1 - 0.073 13.4 0.4 0.31 11.4 0.0 2.0 2 0 0 2 2 2 0 Farnesoic acid 0-methyl transferase Pox_MCEL PF03291.16 KII74904.1 - 0.055 12.6 4.1 1.2 8.2 0.5 2.3 2 0 0 2 2 2 0 mRNA capping enzyme LTD PF00932.19 KII74906.1 - 0.059 13.7 0.2 0.097 13.0 0.2 1.3 1 0 0 1 1 1 0 Lamin Tail Domain SNAP PF14938.6 KII74907.1 - 2.8e-05 23.7 0.0 4.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NSF PF02071.20 KII74907.1 - 0.2 12.5 4.4 1.6 9.8 0.7 3.3 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat RT_RNaseH_2 PF17919.1 KII74908.1 - 9.3e-37 125.1 0.1 2e-36 124.0 0.1 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII74908.1 - 4.3e-36 123.4 0.0 1.2e-35 122.0 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII74908.1 - 2e-26 92.9 0.0 3.3e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII74908.1 - 3.4e-24 85.3 0.0 9.4e-24 83.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74908.1 - 7.1e-17 61.3 1.3 1.9e-16 59.9 1.3 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KII74908.1 - 1.2e-07 31.8 0.0 4.5e-07 30.0 0.0 2.1 1 0 0 1 1 1 1 H2C2 zinc finger gag-asp_proteas PF13975.6 KII74908.1 - 3.9e-05 24.1 0.0 8.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII74908.1 - 4.6e-05 23.3 11.3 0.02 15.0 2.1 2.6 2 0 0 2 2 2 2 Zinc knuckle MLVIN_C PF18697.1 KII74908.1 - 0.03 14.4 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain RVP PF00077.20 KII74908.1 - 0.032 14.5 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 Retroviral aspartyl protease rve_3 PF13683.6 KII74908.1 - 0.043 13.6 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain zf-CCHC_4 PF14392.6 KII74908.1 - 0.054 13.2 7.6 2 8.2 0.6 3.0 1 1 1 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 KII74908.1 - 0.054 14.1 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 Aspartyl protease Spuma_A9PTase PF03539.14 KII74908.1 - 0.063 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP_2 PF08284.11 KII74908.1 - 0.067 13.0 0.2 0.15 11.9 0.2 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease zf-CCHC_6 PF15288.6 KII74908.1 - 0.16 11.8 11.8 0.87 9.5 0.8 2.7 2 0 0 2 2 2 0 Zinc knuckle DDE_3 PF13358.6 KII74912.1 - 0.068 12.9 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Serpin PF00079.20 KII74917.1 - 3e-48 165.0 3.4 3.4e-48 164.8 3.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII74919.1 - 0.00027 20.4 0.0 0.00029 20.3 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDE_Tnp_IS1595 PF12762.7 KII74920.1 - 2e-13 50.6 0.0 2.7e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.14 KII74920.1 - 0.039 13.4 0.0 0.056 12.9 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family Annexin PF00191.20 KII74921.1 - 8.8e-18 64.1 3.8 5.9e-08 32.7 0.2 3.4 4 0 0 4 4 4 3 Annexin Imm9 PF15587.6 KII74921.1 - 0.055 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 9 SLX9 PF15341.6 KII74922.1 - 0.0064 16.9 0.1 0.0085 16.5 0.1 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 HTH_Tnp_Tc5 PF03221.16 KII74924.1 - 1.9e-05 24.6 3.0 8.4e-05 22.5 3.0 2.0 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 KII74924.1 - 0.00077 19.0 0.3 0.0014 18.2 0.3 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.6 KII74924.1 - 0.03 14.1 0.6 0.43 10.4 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain DUF2555 PF10742.9 KII74924.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) HTH_IclR PF09339.10 KII74924.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF5600 PF18150.1 KII74926.1 - 1.4e-30 106.0 0.1 5.2e-30 104.2 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5600) Dynamin_N PF00350.23 KII74926.1 - 5e-13 49.5 0.0 2.1e-11 44.2 0.0 2.4 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.5 KII74926.1 - 3.4e-09 36.4 2.1 7.4e-09 35.4 2.1 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.23 KII74926.1 - 1.2e-08 35.0 0.0 6.2e-08 32.7 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KII74926.1 - 7.1e-05 22.4 0.1 0.00057 19.5 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KII74926.1 - 0.00051 19.5 0.1 0.002 17.5 0.1 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 KII74926.1 - 0.0077 15.8 0.0 0.59 9.7 0.0 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KII74926.1 - 0.012 15.5 0.0 14 5.6 0.0 3.2 3 0 0 3 3 3 0 RsgA GTPase AAA_28 PF13521.6 KII74926.1 - 0.056 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 KII74926.1 - 0.077 12.4 0.1 0.61 9.5 0.0 2.3 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AIG1 PF04548.16 KII74926.1 - 0.084 12.2 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 AIG1 family Roc PF08477.13 KII74926.1 - 0.089 13.0 0.0 1 9.6 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase L_biotic_typeA PF04604.13 KII74926.1 - 0.13 12.1 0.0 1.3 9.0 0.0 2.6 2 0 0 2 2 2 0 Type-A lantibiotic CH PF00307.31 KII74927.1 - 3.4e-14 52.9 0.4 1.4e-11 44.5 0.0 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain ComX PF05952.12 KII74927.1 - 0.078 12.9 0.5 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Bacillus competence pheromone ComX MotB_plug PF13677.6 KII74928.1 - 0.041 13.5 0.2 0.088 12.4 0.2 1.5 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB Ribosomal_L21p PF00829.21 KII74929.1 - 0.062 13.6 0.0 0.09 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal prokaryotic L21 protein EF-hand_2 PF09068.11 KII74930.1 - 0.021 15.0 0.3 0.043 14.0 0.2 1.7 2 0 0 2 2 2 0 EF hand Scm3 PF10384.9 KII74930.1 - 0.13 12.0 1.2 4.5 7.1 0.3 2.7 2 0 0 2 2 2 0 Centromere protein Scm3 Metal_CEHH PF14455.6 KII74930.1 - 0.16 11.6 0.1 1.5 8.4 0.0 2.1 1 1 1 2 2 2 0 Predicted metal binding domain 7TM_GPCR_Srw PF10324.9 KII74931.1 - 0.0092 15.3 0.2 0.014 14.7 0.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Band_7_C PF16200.5 KII74932.1 - 2.6e-16 59.4 0.1 4.9e-16 58.5 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of band_7 DHHC PF01529.20 KII74933.1 - 3.5e-08 33.6 7.4 3.5e-08 33.6 7.4 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase HEAT PF02985.22 KII74934.1 - 3.6e-07 29.9 1.9 0.66 10.4 0.0 5.8 6 0 0 6 6 6 2 HEAT repeat MMS19_C PF12460.8 KII74934.1 - 0.0017 17.6 7.1 0.0018 17.4 0.4 3.2 3 1 1 4 4 4 1 RNAPII transcription regulator C-terminal HEAT_2 PF13646.6 KII74934.1 - 0.0043 17.4 0.0 16 6.0 0.0 3.7 3 0 0 3 3 3 1 HEAT repeats DUF2118 PF09891.9 KII74934.1 - 0.039 13.9 0.2 1.9 8.4 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) IBN_N PF03810.19 KII74934.1 - 0.063 13.2 0.1 0.34 10.9 0.0 2.4 2 0 0 2 2 2 0 Importin-beta N-terminal domain HEAT_EZ PF13513.6 KII74934.1 - 0.21 12.1 0.9 4.7 7.8 0.1 3.6 4 1 0 4 4 4 0 HEAT-like repeat RVT_1 PF00078.27 KII74935.1 - 3.1e-06 26.9 0.0 4.6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 KII74936.1 - 1.9e-11 44.2 0.0 6e-11 42.6 0.0 1.7 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII74936.1 - 1.8e-06 27.9 0.0 4.2e-06 26.7 0.0 1.6 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DUF2183 PF09949.9 KII74936.1 - 0.044 14.1 0.0 0.065 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) SNAP PF14938.6 KII74937.1 - 2.2e-07 30.6 0.3 2.7e-07 30.3 0.3 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 KII74937.1 - 0.15 12.3 2.3 7.3 7.0 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KII74937.1 - 0.61 10.0 2.2 20 5.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RRN3 PF05327.11 KII74939.1 - 0.0004 19.1 1.3 0.00046 18.9 1.3 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DUF3381 PF11861.8 KII74939.1 - 0.0019 18.0 7.0 0.0019 18.0 7.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3381) CDC45 PF02724.14 KII74939.1 - 0.14 10.4 11.6 0.17 10.1 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein TIMELESS_C PF05029.13 KII74939.1 - 0.25 10.5 14.7 0.31 10.1 14.7 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region DUF913 PF06025.12 KII74939.1 - 0.33 9.9 13.2 24 3.7 13.1 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2052 PF09747.9 KII74939.1 - 0.38 10.9 14.8 0.032 14.4 9.3 1.9 1 1 1 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Connexin PF00029.19 KII74939.1 - 0.39 10.4 2.0 0.66 9.7 2.0 1.5 1 0 0 1 1 1 0 Connexin LAP1C PF05609.12 KII74939.1 - 1.6 7.7 8.6 2.1 7.3 8.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CRA_rpt PF07046.11 KII74939.1 - 2.1 8.6 18.1 7.1e+02 0.5 18.1 3.0 1 1 0 1 1 1 0 Cytoplasmic repetitive antigen (CRA) like repeat DUF4554 PF15091.6 KII74939.1 - 4.7 6.0 9.2 6.1 5.6 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Presenilin PF01080.17 KII74939.1 - 5 5.8 9.5 6.7 5.4 9.5 1.3 1 0 0 1 1 1 0 Presenilin Merozoite_SPAM PF07133.11 KII74939.1 - 6.3 6.8 18.3 13 5.7 18.3 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DNA_pol_phi PF04931.13 KII74939.1 - 7.4 4.5 7.0 10 4.1 7.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF3408 PF11888.8 KII74939.1 - 7.5 6.7 31.8 1.6 8.9 14.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3408) Borrelia_P83 PF05262.11 KII74939.1 - 7.6 4.9 10.7 8.9 4.7 10.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein SPT6_acidic PF14632.6 KII74939.1 - 7.9 7.1 23.5 7.6 7.2 17.9 2.2 2 0 0 2 2 2 0 Acidic N-terminal SPT6 YL1 PF05764.13 KII74940.1 - 7.9e-05 22.9 32.7 0.0001 22.5 32.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein LMBR1 PF04791.16 KII74940.1 - 0.0019 17.2 0.4 0.0021 17.0 0.4 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Sin_N PF04801.13 KII74940.1 - 0.005 16.1 2.0 0.005 16.1 2.0 2.0 2 0 0 2 2 2 1 Sin-like protein conserved region TIMELESS_C PF05029.13 KII74940.1 - 0.01 15.1 4.3 0.01 15.1 4.3 2.0 2 0 0 2 2 2 0 Timeless protein C terminal region CPSF100_C PF13299.6 KII74940.1 - 3 8.0 14.3 0.079 13.1 0.7 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 KII74940.1 - 3.6 7.3 26.4 0.12 12.2 3.5 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CENP-B_dimeris PF09026.10 KII74940.1 - 8.4 6.9 12.2 17 5.9 12.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAP PF07174.11 KII74940.1 - 9.5 5.6 20.8 13 5.2 20.8 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DDE_3 PF13358.6 KII74943.1 - 3.9e-07 29.9 0.1 5.5e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_C1 PF00112.23 KII74944.1 - 2.5e-76 256.6 3.0 3.4e-76 256.2 3.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KII74944.1 - 8.1e-09 35.8 0.2 1.7e-08 34.8 0.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KII74944.1 - 1.2e-07 30.8 1.0 3.7e-05 22.7 0.2 2.2 2 0 0 2 2 2 2 Peptidase C1-like family HisKA_2 PF07568.12 KII74945.1 - 0.036 14.1 0.2 0.073 13.2 0.2 1.6 1 0 0 1 1 1 0 Histidine kinase HisKA_2 PF07568.12 KII74946.1 - 0.036 14.1 0.2 0.073 13.2 0.2 1.6 1 0 0 1 1 1 0 Histidine kinase E1_DerP2_DerF2 PF02221.15 KII74947.1 - 1.9e-07 31.6 0.4 2.5e-07 31.2 0.4 1.1 1 0 0 1 1 1 1 ML domain Carb_bind PF10645.9 KII74947.1 - 0.094 12.9 1.7 0.13 12.5 0.2 2.0 2 0 0 2 2 2 0 Carbohydrate binding E1_DerP2_DerF2 PF02221.15 KII74948.1 - 1.4e-07 32.0 0.1 1.8e-07 31.6 0.1 1.2 1 0 0 1 1 1 1 ML domain DUF2838 PF10998.8 KII74949.1 - 0.1 12.8 0.2 0.16 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2838) PaaA_PaaC PF05138.12 KII74949.1 - 0.17 11.0 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein LRR_11 PF18831.1 KII74952.1 - 1.9 8.1 11.8 83 2.9 0.0 6.5 8 0 0 8 8 8 0 Leucine-rich repeat Ribosomal_S3Ae PF01015.18 KII74954.1 - 3.6e-67 225.9 4.0 4.2e-67 225.6 4.0 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Ins134_P3_kin PF05770.11 KII74955.1 - 1.1e-22 80.6 0.2 2e-22 79.7 0.2 1.4 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Ins134_P3_kin_N PF17927.1 KII74955.1 - 3.6e-09 36.9 0.0 7.3e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain DUF1655 PF07868.11 KII74955.1 - 0.028 14.5 0.9 0.076 13.1 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1655) TMEM154 PF15102.6 KII74956.1 - 0.0019 18.1 0.3 0.0029 17.5 0.3 1.3 1 0 0 1 1 1 1 TMEM154 protein family Podoplanin PF05808.11 KII74956.1 - 0.031 14.4 0.4 0.04 14.0 0.4 1.2 1 0 0 1 1 1 0 Podoplanin Protocadherin PF08374.11 KII74956.1 - 0.19 11.7 0.3 0.28 11.1 0.3 1.2 1 0 0 1 1 1 0 Protocadherin AAA PF00004.29 KII74957.1 - 0.13 12.7 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Nup54_C PF18437.1 KII74957.1 - 0.13 12.2 0.6 0.38 10.7 0.6 1.8 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain rve PF00665.26 KII74958.1 - 2.5e-23 82.5 0.0 4.4e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII74958.1 - 9.2e-13 48.1 1.1 2e-12 47.0 1.1 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain rve_3 PF13683.6 KII74958.1 - 2e-05 24.3 0.0 3.8e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 KII74958.1 - 0.0018 18.4 0.3 0.0034 17.6 0.3 1.5 1 0 0 1 1 1 1 H2C2 zinc finger DDE_3 PF13358.6 KII74961.1 - 3e-09 36.8 0.0 4.6e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Daxx PF03344.15 KII74963.1 - 0.02 15.0 0.3 0.13 12.4 0.1 2.1 2 0 0 2 2 2 0 Daxx N-terminal Rassf1C-interacting domain Serpin PF00079.20 KII74965.1 - 1e-20 74.4 0.5 1.2e-20 74.2 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf_C2H2_ZHX PF18387.1 KII74966.1 - 0.088 12.5 3.0 0.19 11.4 0.1 2.6 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-Mss51 PF13824.6 KII74966.1 - 0.099 12.8 1.9 0.49 10.5 1.9 2.1 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf_Hakai PF18408.1 KII74966.1 - 0.32 10.7 4.3 0.5 10.1 1.5 2.6 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain zf-C2H2_4 PF13894.6 KII74966.1 - 0.44 11.5 9.0 3.1 8.9 0.0 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-TRAF PF02176.18 KII74966.1 - 0.64 10.7 9.5 1.6 9.5 4.6 2.5 2 0 0 2 2 2 0 TRAF-type zinc finger zf-C2H2 PF00096.26 KII74966.1 - 0.79 10.3 0.0 0.79 10.3 0.0 4.4 4 1 0 4 4 4 0 Zinc finger, C2H2 type DDE_Tnp_IS1595 PF12762.7 KII74967.1 - 0.0038 17.2 0.0 0.004 17.2 0.0 1.1 1 0 0 1 1 1 1 ISXO2-like transposase domain Col_cuticle_N PF01484.17 KII74971.1 - 0.015 15.3 0.1 0.032 14.3 0.1 1.5 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain DUF220 PF02713.14 KII74972.1 - 0.0027 17.8 0.4 1.1 9.4 0.1 2.8 2 1 1 3 3 3 2 Domain of unknown function DUF220 NRN1 PF15056.6 KII74972.1 - 0.14 12.2 0.6 0.74 9.9 0.2 2.1 2 1 0 2 2 2 0 Neuritin protein family Zot PF05707.12 KII74974.1 - 0.0041 16.8 0.0 0.0048 16.6 0.0 1.1 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) SNAP PF14938.6 KII74975.1 - 6.1e-10 39.0 0.4 7.5e-10 38.7 0.4 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP MIT PF04212.18 KII74975.1 - 0.0019 18.2 0.5 3.1 7.9 0.0 3.0 2 1 1 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 KII74975.1 - 0.028 14.5 0.7 1.7 9.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat NSF PF02071.20 KII74975.1 - 0.14 12.9 2.0 13 7.1 0.0 3.8 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat DUF4383 PF14325.6 KII74976.1 - 0.00069 19.9 5.2 0.00087 19.6 5.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4383) Phage_holin_1 PF04531.13 KII74976.1 - 0.24 12.0 1.5 2.5 8.7 0.0 2.3 2 1 0 2 2 2 0 Bacteriophage holin DUF2981 PF11200.8 KII74976.1 - 4.7 6.9 7.3 5 6.8 7.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2981) Tetraspanin PF00335.20 KII74976.1 - 7.8 6.1 10.7 10 5.8 10.7 1.2 1 0 0 1 1 1 0 Tetraspanin family Kunitz_BPTI PF00014.23 KII74979.1 - 9e-07 29.0 13.4 3.3e-05 24.0 5.0 2.6 2 1 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF287 PF03384.14 KII74983.1 - 0.072 13.5 1.0 0.48 10.9 0.1 2.2 2 0 0 2 2 2 0 Drosophila protein of unknown function, DUF287 DEAD_2 PF06733.15 KII74985.1 - 2.2e-13 50.2 0.7 2.2e-13 50.2 0.7 1.9 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 KII74985.1 - 0.003 17.4 0.2 0.0075 16.0 0.2 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_11 PF13086.6 KII74985.1 - 0.035 13.9 3.2 0.86 9.3 3.2 2.1 1 1 0 1 1 1 0 AAA domain Evr1_Alr PF04777.13 KII74985.1 - 0.076 13.5 1.9 0.11 13.0 1.2 1.7 1 1 0 1 1 1 0 Erv1 / Alr family DEAD_2 PF06733.15 KII74986.1 - 4e-27 94.9 3.8 1.3e-26 93.3 3.8 1.9 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 KII74986.1 - 0.00086 19.5 0.4 0.0037 17.4 0.1 2.1 2 0 0 2 2 2 1 Helicase C-terminal domain SNF2_N PF00176.23 KII74986.1 - 0.041 12.6 0.0 0.067 11.9 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA PF00004.29 KII74986.1 - 0.096 13.1 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KII74986.1 - 0.12 12.6 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain DDE_Tnp_IS1595 PF12762.7 KII74987.1 - 3.5e-13 49.8 0.0 4.3e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DDE_Tnp_IS66 PF03050.14 KII74987.1 - 0.077 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Transposase IS66 family CDC37_M PF08565.11 KII74989.1 - 0.042 13.8 0.2 0.05 13.5 0.2 1.1 1 0 0 1 1 1 0 Cdc37 Hsp90 binding domain ATP_bind_3 PF01171.20 KII74989.1 - 0.064 13.0 0.1 0.07 12.9 0.1 1.2 1 0 0 1 1 1 0 PP-loop family CdiI_2 PF18593.1 KII74991.1 - 0.15 12.7 0.1 0.8 10.4 0.0 2.1 2 0 0 2 2 2 0 CdiI immunity protein Ribosomal_L12_N PF16320.5 KII74997.1 - 0.22 11.2 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain rve PF00665.26 KII74998.1 - 2e-10 40.9 0.0 3.8e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DUF1002 PF06207.11 KII74999.1 - 0.04 13.5 0.0 0.048 13.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) Kelch_6 PF13964.6 KII75001.1 - 4.2e-17 61.8 7.0 6e-06 26.3 0.1 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII75001.1 - 7.6e-12 45.1 1.3 0.014 15.4 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KII75001.1 - 1.1e-11 44.2 7.7 6.1e-05 22.5 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 KII75001.1 - 3.4e-11 42.9 4.6 8.4e-05 22.5 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 KII75001.1 - 8.9e-10 38.6 5.6 0.012 15.9 0.4 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KII75001.1 - 1e-05 25.3 7.2 0.06 13.4 0.1 3.3 3 1 0 3 3 3 2 Kelch motif FBA_3 PF08268.12 KII75001.1 - 0.09 12.7 0.1 0.16 11.9 0.1 1.5 2 0 0 2 2 2 0 F-box associated domain Kelch_1 PF01344.25 KII75002.1 - 7e-08 31.9 3.6 0.017 14.7 0.2 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 KII75002.1 - 1.8e-06 27.9 5.3 0.12 12.4 0.3 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 KII75002.1 - 1.8e-06 28.0 5.0 0.035 14.4 0.2 3.9 3 2 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 KII75002.1 - 0.0019 18.1 4.9 0.11 12.5 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 KII75002.1 - 0.004 17.1 3.2 0.0076 16.2 1.2 2.6 2 1 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 KII75002.1 - 0.013 15.8 3.1 4.3 7.7 0.0 3.5 3 1 0 3 3 3 0 Galactose oxidase, central domain DndB PF14072.6 KII75003.1 - 0.047 12.9 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 DNA-sulfur modification-associated NUC PF18510.1 KII75003.1 - 0.059 13.8 2.8 0.48 10.9 0.2 2.8 2 1 1 3 3 3 0 Nuclease domain SNAP PF14938.6 KII75005.1 - 2.2e-06 27.3 3.6 8.4e-05 22.1 0.1 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP DUF5049 PF16468.5 KII75005.1 - 0.41 10.6 6.2 1.4 8.9 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5049) CHDCT2 PF08074.11 KII75006.1 - 0.0045 17.2 0.2 0.0074 16.5 0.2 1.4 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain SNAP PF14938.6 KII75008.1 - 6.6e-07 29.0 0.2 5.9e-06 25.9 0.2 1.9 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP SNAP PF14938.6 KII75009.1 - 6.7e-05 22.4 0.8 8.8e-05 22.1 0.8 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF2786 PF10979.8 KII75009.1 - 0.053 13.5 0.1 0.51 10.3 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2786) Retrotran_gag_2 PF14223.6 KII75012.1 - 0.00016 21.4 0.1 0.00045 19.9 0.0 1.8 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 KII75012.1 - 0.0014 18.6 1.2 0.0014 18.6 1.2 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 KII75012.1 - 0.0049 16.8 14.8 0.062 13.3 1.4 2.3 1 1 1 2 2 2 2 Zinc knuckle DUF5082 PF16888.5 KII75012.1 - 0.0054 17.0 0.1 0.25 11.6 0.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF5082) HTH_Tnp_1 PF01527.20 KII75012.1 - 0.033 14.5 0.2 1.3 9.4 0.0 2.8 2 1 0 2 2 2 0 Transposase DUF1192 PF06698.11 KII75012.1 - 0.035 14.2 1.5 0.58 10.3 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) SNAP PF14938.6 KII75013.1 - 0.0009 18.7 0.2 0.0012 18.4 0.2 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Rx_N PF18052.1 KII75013.1 - 0.059 13.6 0.2 0.075 13.3 0.2 1.2 1 0 0 1 1 1 0 Rx N-terminal domain SNAP PF14938.6 KII75014.1 - 0.0011 18.5 0.2 0.0014 18.1 0.2 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP MULE PF10551.9 KII75016.1 - 2.5e-10 40.6 0.0 6.8e-10 39.2 0.0 1.7 2 0 0 2 2 2 1 MULE transposase domain SNAP PF14938.6 KII75017.1 - 0.00033 20.2 0.1 0.00035 20.1 0.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RVT_1 PF00078.27 KII75018.1 - 1.3e-26 93.5 0.3 3.5e-26 92.1 0.3 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KII75018.1 - 2.2e-22 79.0 0.0 5.5e-22 77.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII75018.1 - 2.3e-22 79.2 0.1 6.9e-22 77.7 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII75018.1 - 8.8e-19 67.8 0.0 5.1e-18 65.4 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain RVP_2 PF08284.11 KII75018.1 - 5.6e-10 39.1 0.1 1.1e-09 38.2 0.1 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Integrase_H2C2 PF17921.1 KII75018.1 - 3e-08 33.7 0.1 8.7e-08 32.2 0.1 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII75018.1 - 0.00013 22.5 0.0 0.00026 21.5 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 KII75018.1 - 0.00056 19.7 0.0 0.0017 18.1 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.6 KII75018.1 - 0.0029 18.2 0.0 0.0068 17.0 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVT_thumb PF06817.14 KII75018.1 - 0.0046 16.8 0.0 0.017 15.0 0.0 2.0 1 0 0 1 1 1 1 Reverse transcriptase thumb domain MLVIN_C PF18697.1 KII75018.1 - 0.019 15.0 0.0 0.053 13.6 0.0 1.7 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain NCBP3 PF10309.9 KII75018.1 - 0.029 14.2 0.0 0.31 10.9 0.0 2.4 2 0 0 2 2 2 0 Nuclear cap-binding protein subunit 3 RPAP2_Rtr1 PF04181.13 KII75018.1 - 0.12 12.7 0.1 0.12 12.7 0.1 2.6 2 0 0 2 2 2 0 Rtr1/RPAP2 family Ras PF00071.22 KII75019.1 - 6.4e-56 188.4 0.0 7.4e-56 188.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KII75019.1 - 4.1e-24 85.1 0.0 6.4e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KII75019.1 - 2.5e-10 40.1 0.0 4.3e-10 39.3 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KII75019.1 - 0.00033 20.3 0.2 0.00054 19.5 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KII75019.1 - 0.00093 18.7 0.0 0.0031 17.0 0.0 1.7 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KII75019.1 - 0.0014 18.0 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KII75019.1 - 0.045 13.7 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Rad51 PF08423.11 KII75020.1 - 4.4e-129 429.2 0.1 5.3e-129 428.9 0.1 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KII75020.1 - 5.3e-10 39.2 0.0 7.5e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 KII75020.1 - 2.1e-07 30.7 0.2 4.5e-07 29.6 0.2 1.5 1 1 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 KII75020.1 - 6.3e-07 29.0 3.5 1.3e-06 27.9 1.0 2.5 2 1 0 2 2 2 1 KaiC HHH_5 PF14520.6 KII75020.1 - 6e-06 26.8 2.0 6.7e-06 26.6 0.6 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_24 PF13479.6 KII75020.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain RT_RNaseH_2 PF17919.1 KII75021.1 - 1.6e-39 134.0 0.0 4.1e-39 132.7 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII75021.1 - 7.2e-36 122.7 0.1 2.3e-35 121.1 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII75021.1 - 4.1e-31 108.2 0.5 1e-30 106.9 0.5 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII75021.1 - 8.4e-18 64.7 0.0 1.7e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII75021.1 - 1.1e-16 60.6 0.4 3e-16 59.3 0.4 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII75021.1 - 5.7e-06 26.8 0.0 3.3e-05 24.4 0.0 2.3 3 0 0 3 3 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII75021.1 - 3.7e-05 23.6 3.9 0.00012 22.0 3.9 1.9 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 KII75021.1 - 0.00035 21.1 0.1 0.0018 18.9 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-H2C2 PF09337.10 KII75021.1 - 0.0006 20.0 0.4 0.002 18.3 0.4 2.0 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII75021.1 - 0.01 15.6 0.1 0.1 12.4 0.0 2.9 2 0 0 2 2 2 0 Integrase core domain zf-CCHC_4 PF14392.6 KII75021.1 - 0.014 15.1 1.3 0.059 13.1 1.3 2.1 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII75021.1 - 0.02 15.0 0.0 0.052 13.7 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP PF00077.20 KII75021.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease G-patch PF01585.23 KII75022.1 - 5.3e-13 48.6 1.7 7.7e-13 48.1 1.7 1.3 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KII75022.1 - 0.0027 17.8 0.4 0.0044 17.1 0.4 1.5 1 1 0 1 1 1 1 G-patch domain UPF0669 PF17065.5 KII75023.1 - 0.093 12.5 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Putative cytokine, C6ORF120 DnaJ_C PF01556.18 KII75025.1 - 1.1e-34 119.7 0.4 1.5e-34 119.2 0.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KII75025.1 - 3.9e-27 94.2 5.8 7.1e-27 93.3 5.8 1.5 1 0 0 1 1 1 1 DnaJ domain Guanylate_kin PF00625.21 KII75027.1 - 2.4e-16 59.9 0.3 2.8e-16 59.7 0.3 1.1 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 KII75028.1 - 3.6e-11 43.2 0.9 5e-11 42.8 0.9 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KII75028.1 - 3.5e-09 36.4 0.0 5.3e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KII75028.1 - 6.3e-06 26.4 0.1 9.3e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 PDZ domain YHS PF04945.13 KII75028.1 - 0.013 15.6 1.8 0.11 12.6 1.6 2.3 2 0 0 2 2 2 0 YHS domain CorA PF01544.18 KII75029.1 - 0.0024 17.2 0.2 0.0033 16.8 0.2 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Borrelia_rep PF03183.13 KII75029.1 - 0.67 10.1 3.2 1.3 9.2 3.2 1.4 1 0 0 1 1 1 0 Borrelia repeat protein zf-H2C2_2 PF13465.6 KII75030.1 - 4.9e-13 48.8 24.5 2.2e-09 37.3 1.3 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 KII75030.1 - 1.1e-11 44.6 23.6 0.00011 22.4 0.5 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KII75030.1 - 3e-08 33.8 19.4 0.017 15.9 0.2 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KII75030.1 - 0.0018 18.0 1.4 0.0018 18.0 1.4 3.1 3 1 0 3 3 3 1 C2H2-type zinc-finger domain zf-LYAR PF08790.11 KII75030.1 - 0.0035 17.2 3.1 0.0035 17.2 3.1 2.5 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger LIM PF00412.22 KII75030.1 - 0.49 10.6 11.3 0.63 10.3 2.6 2.9 1 1 2 3 3 3 0 LIM domain zinc_ribbon_15 PF17032.5 KII75030.1 - 0.86 10.4 8.5 1.4 9.8 1.2 2.7 1 1 1 2 2 2 0 zinc-ribbon family zf-C2H2_jaz PF12171.8 KII75030.1 - 2.6 8.4 11.8 0.94 9.8 2.7 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KII75030.1 - 9.5 6.8 9.1 13 6.3 2.3 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type MMtag PF10159.9 KII75031.1 - 1.7e-23 82.7 0.2 1.7e-23 82.7 0.2 2.0 2 0 0 2 2 2 1 Multiple myeloma tumor-associated MNE1 PF13762.6 KII75032.1 - 0.016 15.2 4.6 0.033 14.2 0.6 2.7 1 1 0 2 2 2 0 Mitochondrial splicing apparatus component DUF4296 PF14129.6 KII75032.1 - 0.053 14.1 0.1 0.16 12.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) DAOA PF15199.6 KII75033.1 - 0.069 13.6 0.0 0.088 13.2 0.0 1.3 1 0 0 1 1 1 0 D-amino acid oxidase activator Ldl_recept_a PF00057.18 KII75035.1 - 3.5e-08 33.5 11.1 4.9e-08 33.1 11.1 1.2 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A SNAP PF14938.6 KII75036.1 - 1.2e-08 34.8 12.2 1.5e-08 34.4 12.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Fer4_22 PF17179.4 KII75036.1 - 0.7 10.8 4.2 0.24 12.3 0.7 2.0 2 1 0 2 2 2 0 4Fe-4S dicluster domain TPR_2 PF07719.17 KII75036.1 - 3.8 7.9 18.4 2.6 8.4 2.6 5.2 4 1 2 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 KII75036.1 - 6.2 7.0 13.9 2.8 8.1 1.2 4.4 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain Aha1_N PF09229.11 KII75038.1 - 2.2e-21 76.5 0.2 4.2e-21 75.6 0.2 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 KII75038.1 - 1e-17 64.6 0.1 7.8e-17 61.7 0.0 2.1 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein DUF3696 PF12476.8 KII75038.1 - 0.072 13.5 0.7 1.5 9.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3696) JHBP PF06585.11 KII75038.1 - 0.085 12.0 0.2 3.6 6.7 0.1 2.2 1 1 1 2 2 2 0 Haemolymph juvenile hormone binding protein (JHBP) zf-CCHC PF00098.23 KII75039.1 - 0.04 14.0 2.8 0.04 14.0 2.8 2.1 2 0 0 2 2 2 0 Zinc knuckle WD40 PF00400.32 KII75040.1 - 3e-05 24.7 6.9 0.00067 20.4 0.0 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat Pkinase PF00069.25 KII75041.1 - 1.8e-50 171.8 0.1 1.5e-49 168.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII75041.1 - 1.7e-38 132.4 0.1 3.8e-38 131.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KII75041.1 - 0.00094 18.1 1.9 0.0024 16.7 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KII75041.1 - 0.21 11.5 0.3 0.44 10.4 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family APC_u15 PF16636.5 KII75042.1 - 0.15 12.5 1.0 0.15 12.5 1.0 2.6 3 1 0 3 3 3 0 Unstructured region on APC between APC_crr regions 5 and 6 RT_RNaseH_2 PF17919.1 KII75043.1 - 1.6e-39 134.0 0.0 4.1e-39 132.6 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII75043.1 - 7.2e-36 122.7 0.1 2.3e-35 121.1 0.1 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII75043.1 - 4.1e-31 108.2 0.5 1e-30 106.9 0.5 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII75043.1 - 8.4e-18 64.7 0.0 1.7e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII75043.1 - 1.1e-16 60.6 0.4 3e-16 59.3 0.4 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII75043.1 - 5.7e-06 26.8 0.0 3.3e-05 24.4 0.0 2.3 3 0 0 3 3 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII75043.1 - 3.7e-05 23.6 3.9 0.00012 22.0 3.9 1.9 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 KII75043.1 - 0.00036 21.1 0.1 0.0018 18.9 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-H2C2 PF09337.10 KII75043.1 - 0.0006 20.0 0.4 0.002 18.3 0.4 2.0 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII75043.1 - 0.01 15.6 0.1 0.11 12.4 0.0 2.9 2 0 0 2 2 2 0 Integrase core domain zf-CCHC_4 PF14392.6 KII75043.1 - 0.014 15.1 1.3 0.059 13.1 1.3 2.1 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII75043.1 - 0.02 15.0 0.0 0.052 13.7 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP PF00077.20 KII75043.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Pkinase PF00069.25 KII75044.1 - 4.9e-34 117.9 0.0 4.9e-34 117.9 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII75044.1 - 5.1e-26 91.5 3.9 1.1e-25 90.4 0.0 2.6 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KII75044.1 - 3e-05 23.0 14.3 3.6e-05 22.7 0.0 2.4 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KII75044.1 - 0.13 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Apolipoprotein PF01442.18 KII75044.1 - 0.47 10.3 12.8 0.19 11.6 0.5 1.8 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain VirE_N PF08800.10 KII75045.1 - 0.035 14.2 0.3 0.058 13.5 0.3 1.4 1 0 0 1 1 1 0 VirE N-terminal domain DUF507 PF04368.13 KII75047.1 - 0.13 12.2 5.2 1.1 9.1 4.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF507) Serpin PF00079.20 KII75049.1 - 3.5e-46 158.2 5.7 3.9e-46 158.0 5.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Integrin_beta PF00362.18 KII75051.1 - 1.2e-09 38.3 0.3 2e-09 37.5 0.3 1.4 1 0 0 1 1 1 1 Integrin beta chain VWA domain E1_DerP2_DerF2 PF02221.15 KII75053.1 - 1.4e-10 41.8 0.3 1.6e-10 41.6 0.3 1.1 1 0 0 1 1 1 1 ML domain RGS PF00615.19 KII75056.1 - 1.1e-14 54.8 1.1 2.4e-14 53.6 1.1 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain MFS_1 PF07690.16 KII75057.1 - 3.1e-35 121.7 29.4 1.4e-33 116.4 26.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KII75057.1 - 2.6e-10 39.8 4.8 2.6e-10 39.8 4.8 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter DUF4040 PF13244.6 KII75057.1 - 4.7 7.4 7.6 0.23 11.6 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4040) OTU PF02338.19 KII75058.1 - 2.5e-15 57.1 0.2 5e-15 56.1 0.2 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KII75058.1 - 4e-06 26.5 0.2 0.059 12.8 0.0 2.4 2 0 0 2 2 2 2 Peptidase C65 Otubain DUF4280 PF14107.6 KII75058.1 - 0.13 13.1 4.9 0.097 13.5 0.6 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4280) SAM_1 PF00536.30 KII75060.1 - 2.5e-19 69.5 0.9 4.2e-12 46.3 0.1 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.23 KII75060.1 - 4.9e-13 49.3 1.6 3.7e-12 46.5 0.8 2.4 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) SAM_2 PF07647.17 KII75060.1 - 7.7e-11 42.0 1.0 1.6e-05 24.9 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) NCD1 PF04904.13 KII75060.1 - 0.0002 21.3 0.2 0.26 11.3 0.0 2.4 2 0 0 2 2 2 2 NAB conserved region 1 (NCD1) DUF4934 PF16288.5 KII75060.1 - 0.017 15.0 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4934) Ribosomal_S5_C PF03719.15 KII75061.1 - 3.3e-24 84.1 0.0 5.9e-24 83.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KII75061.1 - 8.8e-23 80.1 0.9 1.5e-22 79.3 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain KH_1 PF00013.29 KII75062.1 - 2.5e-18 65.7 0.1 1.3e-09 37.7 0.0 3.7 4 0 0 4 4 4 3 KH domain Secretin_N PF03958.17 KII75062.1 - 0.014 15.7 0.0 11 6.5 0.0 2.6 2 0 0 2 2 2 0 Bacterial type II/III secretion system short domain SLS PF14611.6 KII75062.1 - 0.052 13.4 0.1 0.36 10.6 0.1 2.2 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator DDE_3 PF13358.6 KII75063.1 - 0.015 15.0 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Antimicrobial19 PF08225.11 KII75063.1 - 0.32 10.6 1.8 4.3 7.0 1.1 2.3 2 0 0 2 2 2 0 Pseudin antimicrobial peptide PilS PF08805.11 KII75064.1 - 0.00062 19.6 0.3 0.00095 19.0 0.3 1.3 1 0 0 1 1 1 1 PilS N terminal DUF2193 PF09959.9 KII75064.1 - 0.047 12.1 0.1 0.065 11.7 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) Glyco_hydro_65C PF03633.15 KII75065.1 - 0.12 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain Serpin PF00079.20 KII75066.1 - 5.1e-56 190.6 5.7 6.1e-56 190.3 5.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII75067.1 - 6.2e-47 160.7 6.2 1.8e-46 159.1 6.2 1.6 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) BK_channel_a PF03493.18 KII75067.1 - 0.11 12.7 0.1 0.22 11.7 0.1 1.7 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit Serpin PF00079.20 KII75068.1 - 1.6e-57 195.5 1.3 1.9e-57 195.3 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) TetR_C_2 PF08361.11 KII75068.1 - 0.073 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 MAATS-type transcriptional repressor, C-terminal region Serpin PF00079.20 KII75069.1 - 2.2e-53 181.9 0.2 2.4e-53 181.8 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII75070.1 - 2e-35 122.8 0.4 2.6e-35 122.4 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KII75071.1 - 2e-57 195.2 2.4 2.2e-57 195.1 2.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Bgal_small_N PF02929.17 KII75071.1 - 0.14 11.8 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 Beta galactosidase small chain Gemini_mov PF01708.16 KII75072.1 - 0.1 12.3 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 Geminivirus putative movement protein LAP1C PF05609.12 KII75073.1 - 0.0069 15.5 6.4 0.0087 15.2 6.4 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 KII75073.1 - 1.3 7.5 7.9 1.5 7.3 7.9 1.1 1 0 0 1 1 1 0 Macoilin family DUF1390 PF07150.11 KII75075.1 - 0.15 11.7 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1390) Wzz PF02706.15 KII75077.1 - 0.015 15.6 2.3 0.026 14.8 1.0 1.9 2 0 0 2 2 2 0 Chain length determinant protein VirB8 PF04335.13 KII75077.1 - 0.024 14.5 3.1 0.43 10.4 1.2 2.1 1 1 1 2 2 2 0 VirB8 protein DUF3377 PF11857.8 KII75077.1 - 0.041 13.8 0.8 0.041 13.8 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 KII75077.1 - 0.05 13.5 1.1 0.062 13.2 1.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF5383 PF17355.2 KII75077.1 - 0.095 13.1 0.1 0.13 12.6 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5383) zf-LITAF-like PF10601.9 KII75077.1 - 0.16 12.3 0.9 4.1 7.7 0.0 2.2 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Collectrin PF16959.5 KII75078.1 - 0.00094 19.0 0.0 0.0012 18.6 0.0 1.2 1 0 0 1 1 1 1 Renal amino acid transporter DUF4448 PF14610.6 KII75078.1 - 0.0011 18.8 0.0 0.0014 18.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF1180 PF06679.12 KII75078.1 - 0.0022 18.4 1.0 0.0026 18.2 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) TMEM154 PF15102.6 KII75078.1 - 0.0027 17.6 0.5 0.0037 17.2 0.5 1.2 1 0 0 1 1 1 1 TMEM154 protein family DUF5305 PF17231.2 KII75078.1 - 0.0037 16.7 0.2 0.0039 16.6 0.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5305) STE2 PF02116.15 KII75078.1 - 0.0049 16.2 0.1 0.0059 15.9 0.1 1.2 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR DUF3377 PF11857.8 KII75078.1 - 0.038 13.9 0.0 0.038 13.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) MGC-24 PF05283.11 KII75078.1 - 0.052 14.0 4.0 0.068 13.6 4.0 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Orf78 PF06024.12 KII75078.1 - 0.055 13.8 0.0 0.081 13.2 0.0 1.3 1 0 0 1 1 1 0 Orf78 (ac78) CCSMST1 PF15013.6 KII75078.1 - 0.059 13.5 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 CCSMST1 family Oxidored_q2 PF00420.24 KII75078.1 - 0.06 13.0 0.3 0.083 12.5 0.3 1.3 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Calcyon PF06387.11 KII75078.1 - 0.12 12.3 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) LRR19-TM PF15176.6 KII75078.1 - 0.12 12.4 0.4 0.21 11.6 0.4 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF5383 PF17355.2 KII75078.1 - 0.19 12.1 0.0 0.25 11.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5383) NUP214 PF16755.5 KII75080.1 - 0.00016 21.0 1.3 0.00019 20.8 1.3 1.2 1 1 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 PHD_3 PF13922.6 KII75082.1 - 0.19 12.1 3.3 0.29 11.5 3.3 1.3 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx Fig1 PF12351.8 KII75082.1 - 0.27 11.1 2.6 0.36 10.7 2.6 1.3 1 1 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 OPT PF03169.15 KII75083.1 - 0.011 14.4 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein NAD2 PF18782.1 KII75084.1 - 0.15 12.2 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 rve PF00665.26 KII75087.1 - 0.033 14.4 0.0 0.054 13.7 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Dirigent PF03018.14 KII75088.1 - 0.056 13.2 0.0 1.1 9.0 0.0 2.0 1 1 0 1 1 1 0 Dirigent-like protein Rad21_Rec8 PF04824.16 KII75088.1 - 0.13 11.6 1.3 0.33 10.3 0.1 2.2 3 0 0 3 3 3 0 Conserved region of Rad21 / Rec8 like protein FMN_bind_2 PF04299.12 KII75089.1 - 1.1e-42 145.6 0.0 1.4e-42 145.3 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain Pyridox_ox_2 PF12900.7 KII75089.1 - 0.14 12.2 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase HAT_KAT11 PF08214.11 KII75090.1 - 0.011 15.0 1.0 0.012 15.0 0.7 1.4 1 1 0 1 1 1 0 Histone acetylation protein Bunya_G2 PF03563.13 KII75091.1 - 0.96 8.6 3.9 1.8 7.7 0.0 2.0 2 0 0 2 2 2 0 Bunyavirus glycoprotein G2 Ogr_Delta PF04606.12 KII75095.1 - 1.5e-13 50.5 1.4 2.4e-13 49.8 1.4 1.3 1 0 0 1 1 1 1 Ogr/Delta-like zinc finger Elf1 PF05129.13 KII75095.1 - 0.0099 15.9 0.8 0.016 15.3 0.8 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 KII75095.1 - 0.12 12.3 2.2 0.3 11.0 2.2 1.7 1 1 0 1 1 1 0 zinc-ribbon domain DUF1768 PF08719.11 KII75096.1 - 2.6e-20 73.3 0.0 3.2e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Phage_30_3 PF08010.11 KII75096.1 - 0.11 12.3 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 tRNA-synt_1d PF00750.19 KII75096.1 - 0.19 10.7 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (R) APG12 PF04110.13 KII75097.1 - 0.068 13.6 0.4 0.73 10.3 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 NA37 PF04245.13 KII75098.1 - 4.1e-12 46.2 2.9 6.9e-12 45.5 2.9 1.3 1 0 0 1 1 1 1 37-kD nucleoid-associated bacterial protein DDE_3 PF13358.6 KII75101.1 - 0.0083 15.9 0.0 0.0098 15.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF5453 PF17534.2 KII75102.1 - 0.045 13.7 0.7 0.12 12.4 0.0 1.8 1 1 0 2 2 2 0 Family of unknown function (DUF5453) CE2_N PF17996.1 KII75102.1 - 0.14 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal TFIID-31kDa PF02291.15 KII75106.1 - 6.6e-14 52.0 0.3 9.6e-14 51.5 0.3 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Gal-3-0_sulfotr PF06990.11 KII75107.1 - 5.2e-27 94.8 1.3 2.5e-26 92.5 1.3 1.8 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase HTH_29 PF13551.6 KII75108.1 - 2.3e-07 30.7 0.0 3.1e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 KII75108.1 - 2.9e-06 26.9 0.0 6.4e-06 25.8 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_7 PF02796.15 KII75108.1 - 4.8e-05 23.3 0.0 9.2e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_32 PF13565.6 KII75108.1 - 0.0013 19.3 0.0 0.018 15.7 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 KII75108.1 - 0.012 15.7 0.0 0.027 14.6 0.0 1.5 2 0 0 2 2 2 0 Helix-turn-helix domain PAX PF00292.18 KII75108.1 - 0.047 13.6 0.1 0.074 13.0 0.1 1.3 1 1 0 1 1 1 0 'Paired box' domain HTH_38 PF13936.6 KII75108.1 - 0.087 12.6 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DDE_3 PF13358.6 KII75109.1 - 5.3e-09 36.0 0.0 6.6e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease MINDY_DUB PF04424.13 KII75110.1 - 5.9e-18 65.0 0.1 1.7e-17 63.5 0.1 1.7 2 0 0 2 2 2 1 MINDY deubiquitinase Sortilin_C PF15901.5 KII75112.1 - 5.5e-08 33.3 1.1 8e-08 32.8 1.1 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal TaqI_C PF12950.7 KII75112.1 - 0.023 14.8 0.4 0.036 14.1 0.4 1.3 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain Glyco_transf_7N PF13733.6 KII75113.1 - 1.5e-33 115.3 0.3 1.7e-33 115.1 0.3 1.1 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 CHGN PF05679.16 KII75113.1 - 0.053 12.3 0.0 0.058 12.2 0.0 1.1 1 0 0 1 1 1 0 Chondroitin N-acetylgalactosaminyltransferase DDE_Tnp_IS1595 PF12762.7 KII75115.1 - 7.7e-05 22.7 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain IGR PF09597.10 KII75116.1 - 0.0083 16.2 0.9 0.014 15.5 0.9 1.3 1 0 0 1 1 1 1 IGR protein motif FPL PF09758.9 KII75117.1 - 0.0042 17.1 0.3 0.012 15.7 0.2 1.7 1 1 1 2 2 2 1 Uncharacterised conserved protein Proton_antipo_C PF01010.19 KII75118.1 - 0.015 14.9 0.2 0.016 14.8 0.2 1.1 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus RT_RNaseH PF17917.1 KII75119.1 - 1.7e-33 115.0 0.0 3.7e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII75119.1 - 1.1e-31 108.8 0.0 2.3e-31 107.8 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 KII75119.1 - 1.1e-20 74.0 0.0 3.7e-20 72.3 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII75119.1 - 6.4e-15 55.0 0.0 1.3e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain FLYWCH PF04500.16 KII75120.1 - 0.00014 21.9 2.3 0.00028 21.0 2.1 1.6 1 1 0 1 1 1 1 FLYWCH zinc finger domain Linker_histone PF00538.19 KII75121.1 - 5.6e-24 84.3 0.5 5.6e-24 84.3 0.5 2.5 2 1 0 2 2 2 1 linker histone H1 and H5 family DDE_3 PF13358.6 KII75122.1 - 6.6e-16 58.4 0.0 6.8e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3194 PF11419.8 KII75124.1 - 0.02 15.2 0.3 0.053 13.9 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) RhoGEF PF00621.20 KII75125.1 - 2.5e-21 76.7 2.9 4.4e-21 75.9 2.9 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 KII75125.1 - 0.098 12.9 0.1 0.22 11.8 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Kin17_mid PF10357.9 KII75126.1 - 1.3e-37 128.5 2.1 1.8e-37 128.1 2.1 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 KII75126.1 - 0.0017 18.6 6.8 0.0017 18.6 6.8 2.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KII75126.1 - 0.97 9.9 10.5 0.13 12.7 5.2 2.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF4874 PF16173.5 KII75127.1 - 0.16 11.7 2.2 0.22 11.2 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4874) INCENP_ARK-bind PF03941.15 KII75129.1 - 2.3e-10 40.3 2.1 6.8e-10 38.7 2.1 1.8 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region GP17 PF17420.2 KII75130.1 - 0.017 15.3 0.6 0.036 14.2 0.3 1.8 1 1 0 1 1 1 0 Superinfection exclusion gene product 17 Gp-FAR-1 PF05823.12 KII75130.1 - 0.023 15.0 6.0 0.037 14.4 5.9 1.4 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) MPS2 PF17060.5 KII75130.1 - 0.029 13.7 8.5 0.031 13.5 8.5 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 bZIP_C PF12498.8 KII75130.1 - 0.033 15.2 1.2 0.039 14.9 1.2 1.2 1 0 0 1 1 1 0 Basic leucine-zipper C terminal Tup_N PF08581.10 KII75130.1 - 0.41 11.0 12.6 0.082 13.2 8.7 1.9 2 1 0 2 2 2 0 Tup N-terminal V_ATPase_I PF01496.19 KII75130.1 - 1.8 6.4 10.6 1.9 6.3 10.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDE_3 PF13358.6 KII75131.1 - 9.4e-12 44.9 0.0 2.2e-11 43.7 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease Phage_Gp15 PF06854.11 KII75134.1 - 0.012 15.6 0.6 0.023 14.7 0.5 1.6 1 1 1 2 2 2 0 Bacteriophage Gp15 protein gag-asp_proteas PF13975.6 KII75134.1 - 0.025 15.1 0.0 0.07 13.7 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease OrfB_Zn_ribbon PF07282.11 KII75134.1 - 0.052 13.5 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain RVP PF00077.20 KII75134.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Rubredoxin_2 PF18073.1 KII75134.1 - 0.41 10.4 3.5 0.89 9.3 3.5 1.6 1 1 0 1 1 1 0 Rubredoxin metal binding domain RVT_1 PF00078.27 KII75136.1 - 4.2e-12 46.1 0.1 6.6e-12 45.4 0.1 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lactamase_B_4 PF13691.6 KII75136.1 - 0.15 11.8 0.0 0.85 9.3 0.0 2.2 2 0 0 2 2 2 0 tRNase Z endonuclease Yip1 PF04893.17 KII75137.1 - 7.4e-07 29.0 16.6 1.1e-06 28.5 16.6 1.3 1 1 0 1 1 1 1 Yip1 domain DUF3392 PF11872.8 KII75137.1 - 0.023 14.9 1.9 0.067 13.4 1.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3392) Ribosom_S12_S23 PF00164.25 KII75139.1 - 1e-51 173.4 1.5 1.3e-51 173.0 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 ATP12 PF07542.11 KII75141.1 - 3.2e-09 36.9 0.1 3.9e-09 36.7 0.1 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Adeno_E3_CR2 PF02439.15 KII75142.1 - 0.0095 15.7 1.9 0.016 14.9 1.9 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Tmemb_185A PF10269.9 KII75142.1 - 0.033 13.9 0.2 0.037 13.7 0.2 1.1 1 0 0 1 1 1 0 Transmembrane Fragile-X-F protein Rer1 PF03248.13 KII75142.1 - 0.1 12.3 0.1 0.14 11.9 0.1 1.1 1 0 0 1 1 1 0 Rer1 family TMEM154 PF15102.6 KII75142.1 - 0.12 12.2 2.9 0.42 10.5 2.9 1.8 1 1 0 1 1 1 0 TMEM154 protein family Insulin_TMD PF17870.1 KII75142.1 - 0.25 11.4 1.9 0.34 11.0 1.9 1.2 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Ceramidase PF05875.12 KII75143.1 - 3.3e-20 72.6 0.6 5.5e-20 71.9 0.6 1.3 1 0 0 1 1 1 1 Ceramidase DDE_3 PF13358.6 KII75143.1 - 3e-09 36.8 0.2 0.00015 21.5 0.4 3.4 1 1 1 2 2 2 2 DDE superfamily endonuclease zf-CCHC_3 PF13917.6 KII75144.1 - 2.2e-15 56.3 8.1 4.6e-15 55.3 8.1 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 KII75144.1 - 0.0027 17.7 2.3 0.0039 17.2 2.3 1.3 1 0 0 1 1 1 1 Zinc knuckle DGCR6 PF07324.11 KII75144.1 - 0.1 12.2 1.5 0.13 11.8 1.5 1.1 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein Cas6b_C PF17262.2 KII75144.1 - 0.11 12.6 0.2 0.18 11.9 0.2 1.3 1 0 0 1 1 1 0 Cas6b C-terminal domain Peptidase_M43 PF05572.13 KII75145.1 - 0.039 13.9 0.2 0.29 11.0 0.2 2.0 1 1 0 1 1 1 0 Pregnancy-associated plasma protein-A Cytochrom_C PF00034.21 KII75146.1 - 1.4e-09 39.0 0.0 1.9e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 KII75146.1 - 1.8e-06 28.1 0.6 5.7e-06 26.6 0.6 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 KII75146.1 - 0.0041 16.8 0.5 0.016 14.9 0.5 2.1 1 1 0 1 1 1 1 Cytochrome c-550 domain MCR PF18509.1 KII75146.1 - 0.02 14.5 0.5 0.031 13.9 0.5 1.3 1 0 0 1 1 1 0 Magnetochrome domain Apolipoprotein PF01442.18 KII75147.1 - 0.0073 16.2 1.8 0.011 15.7 1.8 1.3 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Mating_N PF12731.7 KII75147.1 - 0.049 13.7 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 Mating-type protein beta 1 Phe_tRNA-synt_N PF02912.18 KII75147.1 - 0.051 13.5 1.3 0.051 13.5 1.3 2.9 3 0 0 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain DUF948 PF06103.11 KII75147.1 - 0.097 12.9 2.5 11 6.4 3.0 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) YtxH PF12732.7 KII75147.1 - 0.11 13.1 6.4 5.9 7.5 6.4 2.8 1 1 0 1 1 1 0 YtxH-like protein Exonuc_VII_L PF02601.15 KII75147.1 - 0.12 11.9 5.3 0.15 11.6 5.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF883 PF05957.13 KII75147.1 - 0.13 12.9 1.8 0.82 10.3 0.3 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Evr1_Alr PF04777.13 KII75147.1 - 0.2 12.2 3.4 5.5 7.5 0.1 2.2 1 1 1 2 2 2 0 Erv1 / Alr family Tweety PF04906.13 KII75147.1 - 0.37 9.4 3.5 0.97 8.0 1.3 1.9 1 1 1 2 2 2 0 Tweety V_ATPase_I PF01496.19 KII75147.1 - 0.37 8.6 7.3 0.46 8.3 7.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-4B PF06273.11 KII75147.1 - 0.49 9.4 8.3 0.63 9.0 8.3 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B DUF5347 PF17282.2 KII75147.1 - 0.72 10.2 6.3 1 9.7 1.5 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5347) TnpV PF14198.6 KII75147.1 - 1 9.4 6.9 2.3 8.2 3.6 2.1 1 1 1 2 2 2 0 Transposon-encoded protein TnpV FidL_like PF15941.5 KII75147.1 - 1.9 9.0 6.4 3.9 8.0 0.7 2.2 1 1 0 2 2 2 0 FidL-like putative membrane protein SpmSyn_N PF17950.1 KII75147.1 - 5 7.4 5.8 18 5.6 0.5 3.1 2 1 1 3 3 3 0 S-adenosylmethionine decarboxylase N -terminal ACCA PF03255.14 KII75147.1 - 7.5 6.4 8.7 7.3 6.5 5.0 2.0 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Pkinase PF00069.25 KII75149.1 - 5.2e-62 209.6 0.2 6.3e-62 209.3 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KII75149.1 - 6.6e-34 117.4 0.1 8.6e-34 117.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KII75149.1 - 0.001 18.1 0.9 0.0021 17.1 0.9 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KII75149.1 - 0.0017 17.5 0.0 0.0032 16.6 0.0 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 KII75149.1 - 0.0096 15.3 0.2 0.17 11.1 0.0 2.5 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KII75149.1 - 0.05 12.4 0.0 0.073 11.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 KII75149.1 - 0.076 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KII75149.1 - 0.11 12.1 0.7 0.31 10.6 0.1 1.9 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 KII75149.1 - 0.21 11.5 0.0 0.33 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 KII75149.1 - 0.21 11.2 1.0 2.1 7.9 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DDE_3 PF13358.6 KII75150.1 - 1.6e-15 57.1 0.0 3.2e-15 56.1 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 KII75150.1 - 2.1e-07 30.5 0.0 3.6e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.18 KII75150.1 - 0.012 15.9 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 0 Transposase DDE_Tnp_ISAZ013 PF07592.11 KII75150.1 - 0.064 12.2 0.1 3.1 6.7 0.0 2.1 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain zf-UBR PF02207.20 KII75152.1 - 1.5e-07 31.5 11.8 4.1e-07 30.1 11.8 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 KII75152.1 - 0.051 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS Bul1_N PF04425.12 KII75155.1 - 0.03 13.1 0.0 0.041 12.6 0.0 1.1 1 0 0 1 1 1 0 Bul1 N terminus GGDEF_2 PF17853.1 KII75156.1 - 0.0094 16.2 0.0 2.9 8.2 0.0 2.3 2 0 0 2 2 2 2 GGDEF-like domain BLOC1_2 PF10046.9 KII75156.1 - 0.017 15.4 1.1 0.047 14.0 1.1 1.8 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RuBisCO_small PF00101.20 KII75156.1 - 0.018 15.0 1.7 0.3 11.1 0.1 2.9 2 1 0 2 2 2 0 Ribulose bisphosphate carboxylase, small chain COX16 PF14138.6 KII75156.1 - 0.02 15.4 1.2 0.06 13.9 1.2 1.8 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 HHH_8 PF14716.6 KII75156.1 - 2.3 8.6 6.0 0.34 11.3 1.5 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix domain DUF1985 PF09331.11 KII75156.1 - 3.2 7.8 7.5 0.53 10.3 0.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1985) rve PF00665.26 KII75160.1 - 1.5e-05 25.1 0.0 2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Glyco_hydro_cc PF11790.8 KII75160.1 - 0.036 13.6 0.1 0.038 13.5 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase catalytic core Retrotrans_gag PF03732.17 KII75161.1 - 0.00018 21.7 0.6 0.0005 20.3 0.2 1.9 1 1 1 2 2 2 1 Retrotransposon gag protein RPAP3_C PF13877.6 KII75161.1 - 0.034 14.7 1.0 0.25 11.9 0.2 2.2 1 1 0 2 2 2 0 Potential Monad-binding region of RPAP3 Sortilin-Vps10 PF15902.5 KII75163.1 - 4.5e-14 52.1 0.1 7.8e-14 51.3 0.1 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KII75163.1 - 4.4e-11 43.4 0.7 4.4e-11 43.4 0.7 2.0 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 KII75163.1 - 0.00011 21.7 9.5 0.27 11.4 0.2 4.0 4 0 0 4 4 4 3 BNR/Asp-box repeat Anth_Ig PF05587.13 KII75163.1 - 0.051 13.9 2.2 0.15 12.4 0.6 2.4 2 0 0 2 2 2 0 Anthrax receptor extracellular domain DUF4768 PF15989.5 KII75163.1 - 0.19 11.7 1.4 0.3 11.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4768) Ldl_recept_a PF00057.18 KII75164.1 - 2e-09 37.5 8.5 2e-09 37.5 8.5 1.8 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.5 KII75165.1 - 4.7e-16 59.6 1.8 9.6e-16 58.6 1.8 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII75165.1 - 7e-08 31.7 0.2 2.6e-06 26.5 0.0 2.6 3 0 0 3 3 3 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII75165.1 - 3.8e-07 30.2 11.1 3.8e-07 30.2 11.1 2.4 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A BNR PF02012.20 KII75165.1 - 0.018 14.9 2.2 7.4 7.0 0.0 3.1 2 0 0 2 2 2 0 BNR/Asp-box repeat TaqI_C PF12950.7 KII75165.1 - 0.13 12.3 0.7 0.38 10.8 0.2 2.0 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain RT_RNaseH PF17917.1 KII75169.1 - 7.4e-36 122.6 0.1 4.5e-35 120.1 0.0 2.4 3 0 0 3 3 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 KII75169.1 - 1.6e-33 114.7 0.6 9e-33 112.3 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII75169.1 - 2.7e-29 102.3 0.1 5.8e-29 101.2 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII75169.1 - 4.6e-26 91.4 0.1 3.7e-25 88.4 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 KII75169.1 - 2.3e-17 62.8 1.6 2.3e-17 62.8 1.6 2.5 3 0 0 3 3 2 1 Integrase zinc binding domain rve_3 PF13683.6 KII75169.1 - 6.5e-05 22.6 0.2 0.00038 20.2 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KII75169.1 - 0.00021 21.4 1.4 0.00078 19.6 0.1 2.7 3 0 0 3 3 2 1 H2C2 zinc finger MLVIN_C PF18697.1 KII75169.1 - 0.00033 20.7 0.0 0.00093 19.2 0.0 1.8 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Asp_protease_2 PF13650.6 KII75169.1 - 0.0031 18.1 0.0 0.01 16.5 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 KII75169.1 - 0.0042 17.4 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 KII75169.1 - 0.005 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KII75169.1 - 0.014 16.0 0.0 0.037 14.6 0.0 1.8 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease CotJB PF12652.7 KII75169.1 - 0.037 14.2 2.7 0.29 11.4 0.1 3.0 3 0 0 3 3 2 0 CotJB protein TetR_C_15 PF17918.1 KII75169.1 - 0.052 14.3 0.0 3.7 8.4 0.1 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HetR_C PF18460.1 KII75169.1 - 0.076 12.9 0.0 5.3 7.0 0.0 3.4 3 0 0 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain PaaX_C PF08223.11 KII75169.1 - 0.088 13.1 0.1 0.43 10.9 0.0 2.2 2 0 0 2 2 1 0 PaaX-like protein C-terminal domain DUF4070 PF13282.6 KII75169.1 - 0.11 12.7 0.0 1.3 9.1 0.0 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4070) Retrotran_gag_2 PF14223.6 KII75169.1 - 0.13 11.9 0.5 3.7 7.2 0.0 3.0 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type RVP_2 PF08284.11 KII75169.1 - 0.14 12.0 0.2 0.33 10.7 0.2 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease T4bSS_IcmS PF12608.8 KII75169.1 - 0.18 12.2 0.0 0.48 10.8 0.0 1.7 1 0 0 1 1 1 0 Type IVb secretion, IcmS, effector-recruitment zf-CCHC_3 PF13917.6 KII75169.1 - 1.4 9.0 9.8 5 7.2 1.3 2.6 1 1 1 2 2 2 0 Zinc knuckle Zn_Tnp_IS91 PF14319.6 KII75169.1 - 9 6.4 8.3 5.5 7.1 1.6 3.5 3 0 0 3 3 3 0 Transposase zinc-binding domain SNAP PF14938.6 KII75170.1 - 3.5e-07 29.9 1.9 4.5e-07 29.6 1.9 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR PF01535.20 KII75170.1 - 0.023 14.9 0.5 0.39 11.1 0.0 2.8 3 0 0 3 3 3 0 PPR repeat Ribonuclease_T2 PF00445.18 KII75170.1 - 0.07 13.4 0.2 0.092 13.0 0.2 1.2 1 0 0 1 1 1 0 Ribonuclease T2 family PA28_beta PF02252.18 KII75170.1 - 0.47 10.1 3.6 0.28 10.8 0.4 2.0 2 1 0 2 2 2 0 Proteasome activator pa28 beta subunit Ldl_recept_a PF00057.18 KII75171.1 - 6.1e-35 119.2 103.0 1.3e-10 41.4 3.5 6.3 6 0 0 6 6 6 6 Low-density lipoprotein receptor domain class A DUF1948 PF09185.10 KII75171.1 - 0.13 12.2 0.8 0.6 10.0 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1948) rve PF00665.26 KII75172.1 - 0.00035 20.7 0.0 0.00084 19.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 KII75172.1 - 0.00039 20.0 0.2 0.0009 18.8 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1758 PF05585.12 KII75172.1 - 0.00061 19.6 1.5 0.02 14.7 1.5 2.5 1 1 0 1 1 1 1 Putative peptidase (DUF1758) gag-asp_proteas PF13975.6 KII75172.1 - 0.18 12.4 0.0 0.43 11.2 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease RVT_1 PF00078.27 KII75173.1 - 3.9e-14 52.7 0.1 5.3e-14 52.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L32e PF01655.18 KII75175.1 - 2.1e-45 153.5 0.4 2.6e-45 153.3 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 EFG_IV PF03764.18 KII75176.1 - 5.8e-30 103.6 0.0 1.3e-29 102.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 KII75176.1 - 8.9e-19 67.3 0.0 1.8e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KII75176.1 - 6.5e-15 55.0 0.0 1.3e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 KII75176.1 - 1.1e-06 28.9 0.0 2.7e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RT_RNaseH_2 PF17919.1 KII75178.1 - 2e-39 133.7 0.0 4.9e-39 132.4 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 KII75178.1 - 9e-36 122.3 0.1 2.7e-35 120.8 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 KII75178.1 - 5.1e-31 107.9 0.5 1.2e-30 106.6 0.5 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 KII75178.1 - 1e-17 64.4 0.0 2e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 KII75178.1 - 1.2e-16 60.5 0.4 3.5e-16 59.1 0.4 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain gag-asp_proteas PF13975.6 KII75178.1 - 7.4e-06 26.4 0.0 3.9e-05 24.1 0.0 2.2 3 0 0 3 3 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 KII75178.1 - 4.1e-05 23.5 3.9 0.00013 21.8 3.9 1.9 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 KII75178.1 - 0.00046 20.8 0.1 0.0021 18.6 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-H2C2 PF09337.10 KII75178.1 - 0.00072 19.7 0.4 0.0024 18.1 0.4 2.0 1 0 0 1 1 1 1 H2C2 zinc finger rve_3 PF13683.6 KII75178.1 - 0.014 15.2 0.1 0.12 12.1 0.0 2.8 2 0 0 2 2 2 0 Integrase core domain zf-CCHC_4 PF14392.6 KII75178.1 - 0.015 15.0 1.3 0.068 12.9 1.3 2.2 2 0 0 2 2 2 0 Zinc knuckle Spuma_A9PTase PF03539.14 KII75178.1 - 0.023 14.8 0.0 0.061 13.5 0.0 1.7 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RVP PF00077.20 KII75178.1 - 0.066 13.5 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Albumin_I_a PF16720.5 KII75179.1 - 0.012 15.4 0.7 0.22 11.5 0.1 2.7 3 0 0 3 3 3 0 Albumin I chain a DUF2057 PF09829.9 KII75179.1 - 0.24 11.5 0.9 0.33 11.1 0.2 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Baculo_p24 PF05073.12 KII75181.1 - 0.074 12.8 0.1 0.084 12.6 0.1 1.1 1 0 0 1 1 1 0 Baculovirus P24 capsid protein DUF1940 PF09155.10 KII75181.1 - 0.084 13.0 0.5 0.21 11.7 0.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1940) DUF4110 PF13422.6 KII75185.1 - 0.099 12.7 0.1 0.26 11.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) DDE_3 PF13358.6 KII75186.1 - 1.9e-07 31.0 0.1 5.7e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease RVT_1 PF00078.27 KII75187.1 - 0.00093 18.8 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAM60A PF15396.6 KII75199.1 - 2.2e-07 31.1 0.1 3.4e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Protein Family FAM60A DUF3304 PF11745.8 KII75199.1 - 0.018 15.4 0.9 0.094 13.1 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3304) Chordopox_G3 PF06129.12 KII75200.1 - 0.062 14.0 0.0 0.38 11.5 0.0 2.1 2 0 0 2 2 2 0 Chordopoxvirus G3 protein Med14 PF08638.11 KII75201.1 - 1.4e-21 76.8 0.1 2.6e-21 75.9 0.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 Ycf15 PF10705.9 KII75201.1 - 0.24 11.6 3.7 0.56 10.4 2.3 2.3 2 0 0 2 2 2 0 Chloroplast protein precursor Ycf15 putative TFIIS_C PF01096.18 KII75203.1 - 1.3e-14 53.7 3.7 1.3e-14 53.7 3.7 2.9 4 0 0 4 4 4 1 Transcription factor S-II (TFIIS) DZR PF12773.7 KII75203.1 - 2.5e-06 27.4 9.0 0.00092 19.2 1.9 2.2 2 0 0 2 2 2 2 Double zinc ribbon A2L_zn_ribbon PF08792.10 KII75203.1 - 0.0014 18.3 12.3 0.85 9.4 2.9 3.4 3 0 0 3 3 3 2 A2L zinc ribbon domain C1_1 PF00130.22 KII75203.1 - 0.0036 17.1 10.7 0.0071 16.2 2.5 3.0 1 1 2 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Baculo_LEF5_C PF11792.8 KII75203.1 - 0.064 12.9 0.0 0.064 12.9 0.0 2.7 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain zf-RRPl_C4 PF17026.5 KII75203.1 - 0.21 11.7 8.6 0.35 11.0 8.6 1.3 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type HypA PF01155.19 KII75203.1 - 1.7 8.7 7.8 1.8 8.6 3.6 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PHD PF00628.29 KII75203.1 - 2.2 8.2 12.9 0.67 9.9 2.6 2.8 2 1 0 2 2 2 0 PHD-finger Rpr2 PF04032.16 KII75203.1 - 3.8 7.9 13.3 1.9e+02 2.4 13.3 2.9 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn_ribbon_recom PF13408.6 KII75203.1 - 9.7 6.8 12.9 0.66 10.5 1.2 2.8 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain COP23 PF14218.6 KII75204.1 - 0.033 13.9 0.0 0.044 13.6 0.0 1.1 1 0 0 1 1 1 0 Circadian oscillating protein COP23 FANCI_HD1 PF14679.6 KII75206.1 - 0.099 12.6 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 FANCI helical domain 1 IMPDH PF00478.25 KII75208.1 - 0.04 12.9 0.2 0.044 12.8 0.2 1.1 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain Hce2 PF14856.6 KII75208.1 - 0.048 13.9 0.1 0.075 13.3 0.1 1.3 1 1 0 1 1 1 0 Pathogen effector; putative necrosis-inducing factor Stap_Strp_tox_C PF02876.17 KII75209.1 - 0.039 14.2 0.5 0.095 13.0 0.5 1.7 1 1 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain DUF515 PF04415.12 KII75210.1 - 0.06 11.7 0.5 0.065 11.6 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Glyco_transf_10 PF00852.19 KII75211.1 - 2.5e-38 131.6 1.2 4.1e-38 130.9 1.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_transf_10 PF00852.19 KII75213.1 - 3.7e-31 108.2 0.1 4.4e-31 108.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Sortilin_C PF15901.5 KII75214.1 - 1.6e-12 48.1 4.2 1.6e-12 48.1 4.2 2.0 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 KII75214.1 - 1.2e-08 34.3 0.3 2.3e-06 26.7 0.0 2.6 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.18 KII75214.1 - 1.9e-06 28.0 11.3 1.9e-06 28.0 11.3 4.1 5 0 0 5 5 5 1 Low-density lipoprotein receptor domain class A Fucokinase PF07959.12 KII75214.1 - 0.01 14.8 1.6 0.02 13.8 1.6 1.4 1 0 0 1 1 1 0 L-fucokinase BNR PF02012.20 KII75214.1 - 2.4 8.5 10.8 11 6.5 0.3 4.3 4 0 0 4 4 4 0 BNR/Asp-box repeat Frag1 PF10277.9 KII75215.1 - 7.6e-05 22.4 14.8 8.8e-05 22.1 14.8 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family ABC2_membrane_3 PF12698.7 KII75215.1 - 5.6 6.0 20.4 0.86 8.6 16.7 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein Frag1 PF10277.9 KII75216.1 - 2e-07 30.8 16.1 2e-07 30.8 16.1 1.8 1 1 1 2 2 2 1 Frag1/DRAM/Sfk1 family EamA PF00892.20 KII75216.1 - 0.0073 16.5 7.2 0.0073 16.5 7.2 1.5 2 0 0 2 2 2 1 EamA-like transporter family HTH_Tnp_4 PF13613.6 KII75219.1 - 0.12 12.1 2.1 0.54 10.0 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix of DDE superfamily endonuclease Peptidase_C54 PF03416.19 KII75223.1 - 0.26 10.7 1.4 12 5.2 0.1 2.1 1 1 0 2 2 2 0 Peptidase family C54 Importin_rep_3 PF18806.1 KII75227.1 - 0.025 14.6 0.0 2.9 8.0 0.0 2.4 2 0 0 2 2 2 0 Importin 13 repeat ARL2_Bind_BART PF11527.8 KII75228.1 - 0.071 13.2 0.1 0.094 12.8 0.1 1.1 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART DUF4258 PF14076.6 KII96221.1 - 0.11 12.9 0.0 0.16 12.4 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4258) # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Myxozoa/Thelohanellus_kitauei-ASM82789v1/GCA_000827895.1_ASM82789v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Myxozoa/Thelohanellus_kitauei-ASM82789v1/GCA_000827895.1_ASM82789v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Myxozoa/Thelohanellus_kitauei-ASM82789v1/GCA_000827895.1_ASM82789v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Myxozoa/Thelohanellus_kitauei-ASM82789v1/GCA_000827895.1_ASM82789v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 18:20:47 2019 # [ok]