# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- GMC_oxred_N PF00732.19 OPL07194.1 - 5e-12 45.8 0.0 5.2e-12 45.7 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase DUF3718 PF12514.8 OPL07194.1 - 0.063 13.4 0.1 0.065 13.4 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3718) AAA_8 PF12780.7 OPL07195.1 - 7.8e-09 35.2 0.3 9.5e-09 35.0 0.3 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Pox_L3_FP4 PF03339.14 OPL07195.1 - 0.019 14.0 0.1 0.022 13.8 0.1 1.1 1 0 0 1 1 1 0 Poxvirus L3/FP4 protein Mo25 PF08569.11 OPL07195.1 - 0.061 12.7 0.6 0.062 12.7 0.6 1.1 1 0 0 1 1 1 0 Mo25-like Ank_4 PF13637.6 OPL07196.1 - 8e-42 141.1 2.1 1.5e-15 57.3 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL07196.1 - 3.5e-30 100.7 1.2 2.1e-07 30.7 0.0 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.7 OPL07196.1 - 1.5e-29 102.4 1.9 6.3e-16 58.7 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 OPL07196.1 - 2.8e-24 84.4 2.8 1.6e-06 28.3 0.0 4.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 OPL07196.1 - 7.3e-22 77.1 0.4 8.6e-07 29.1 0.0 3.8 1 1 3 4 4 4 3 Ankyrin repeats (many copies) FeS PF04060.13 OPL07196.1 - 0.00015 21.4 1.6 20 4.9 0.0 4.2 4 0 0 4 4 4 1 Putative Fe-S cluster Rbsn PF11464.8 OPL07196.1 - 0.047 13.4 0.0 67 3.3 0.0 3.4 3 0 0 3 3 3 0 Rabenosyn Rab binding domain Helicase_PWI PF18149.1 OPL07196.1 - 0.08 13.1 2.6 2.5 8.3 0.1 3.1 2 1 0 3 3 3 0 N-terminal helicase PWI domain Peptidase_S8 PF00082.22 OPL07197.1 - 0.0059 15.9 1.6 0.0081 15.4 1.3 1.4 1 1 0 1 1 1 1 Subtilase family FAM219A PF15260.6 OPL07197.1 - 0.011 16.1 0.4 0.014 15.7 0.4 1.1 1 0 0 1 1 1 0 Protein family FAM219A FlgO PF17680.1 OPL07198.1 - 0.023 14.4 3.0 1.7 8.4 0.4 2.1 2 0 0 2 2 2 0 FlgO protein L27 PF02828.16 OPL07198.1 - 0.023 14.4 0.3 2.9 7.7 0.0 2.2 2 0 0 2 2 2 0 L27 domain GidB PF02527.15 OPL07198.1 - 0.04 13.2 2.6 0.98 8.7 0.2 2.1 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G DUF1473 PF07341.11 OPL07198.1 - 0.057 13.2 0.3 7.5 6.3 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1473) LepA_C PF06421.12 OPL07198.1 - 1.6 8.9 7.0 7.7 6.7 1.0 2.1 2 0 0 2 2 2 0 GTP-binding protein LepA C-terminus adh_short PF00106.25 OPL07199.1 - 8.9e-26 90.6 0.0 9.5e-26 90.5 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL07199.1 - 3.2e-11 43.2 0.0 3.5e-11 43.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase TSP_3 PF02412.18 OPL07202.1 - 1.6e-14 53.3 27.1 2.1e-07 30.5 11.5 2.1 2 0 0 2 2 2 2 Thrombospondin type 3 repeat TSP_C PF05735.12 OPL07202.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Thrombospondin C-terminal region FH2 PF02181.23 OPL07203.1 - 4.8e-09 35.8 0.4 5e-09 35.7 0.4 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain Ank_4 PF13637.6 OPL07205.1 - 6.7e-30 103.1 1.3 3.5e-12 46.6 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL07205.1 - 3.5e-24 85.2 1.6 1.7e-16 60.6 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 OPL07205.1 - 3.5e-21 73.0 3.3 7.3e-06 26.0 0.0 4.9 4 1 1 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 OPL07205.1 - 5.7e-18 64.7 0.1 2.2e-07 31.0 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 OPL07205.1 - 2.2e-17 62.6 3.0 0.00027 21.3 0.0 4.5 4 1 1 5 5 5 4 Ankyrin repeat DUF354 PF04007.12 OPL07205.1 - 0.029 13.5 0.5 0.47 9.5 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF354) 2-Hacid_dh PF00389.30 OPL07206.1 - 5.8e-25 87.5 0.1 6.7e-25 87.3 0.1 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain BAF PF02961.14 OPL07207.1 - 7e-16 58.4 0.1 9.1e-16 58.1 0.1 1.2 1 0 0 1 1 1 1 Barrier to autointegration factor Abhydrolase_3 PF07859.13 OPL07208.1 - 2.7e-09 37.2 0.0 3.3e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 OPL07208.1 - 0.00057 18.9 0.0 0.0006 18.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family PhoPQ_related PF10142.9 OPL07208.1 - 0.19 10.3 0.0 0.19 10.3 0.0 1.0 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Trypsin PF00089.26 OPL07209.1 - 5.4e-09 36.2 0.0 5.7e-09 36.1 0.0 1.0 1 0 0 1 1 1 1 Trypsin TPR_12 PF13424.6 OPL07210.1 - 8.3e-05 22.8 0.2 0.065 13.5 0.0 2.2 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 OPL07210.1 - 0.00028 20.9 3.1 0.00085 19.4 0.3 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 OPL07210.1 - 0.0007 19.3 4.2 0.0015 18.3 0.3 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 OPL07210.1 - 0.0084 16.2 1.3 0.02 15.0 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat SNAP PF14938.6 OPL07210.1 - 0.019 14.4 4.9 0.2 11.0 0.4 2.1 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 OPL07210.1 - 0.038 14.4 0.2 0.36 11.3 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 OPL07210.1 - 0.2 11.8 1.3 1.1 9.4 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 OPL07211.1 - 1.9e-08 34.8 4.8 0.00033 21.4 0.2 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 OPL07211.1 - 0.0012 19.0 0.0 0.0087 16.3 0.0 2.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 OPL07211.1 - 0.023 14.6 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A zf-B_box PF00643.24 OPL07214.1 - 2.2e-08 34.1 13.4 2.2e-08 34.1 13.4 1.9 2 0 0 2 2 2 1 B-box zinc finger WWE PF02825.20 OPL07215.1 - 2.1e-06 28.2 0.2 4.9e-06 27.0 0.1 1.7 1 1 1 2 2 2 1 WWE domain DUF3107 PF11305.8 OPL07215.1 - 0.045 14.0 0.1 0.26 11.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3107) TIG PF01833.24 OPL07217.1 - 0.00057 19.9 0.1 0.0008 19.4 0.1 1.3 1 0 0 1 1 1 1 IPT/TIG domain TIG PF01833.24 OPL07218.1 - 0.00075 19.5 0.1 0.0011 19.0 0.1 1.3 1 0 0 1 1 1 1 IPT/TIG domain MRNIP PF15749.5 OPL07219.1 - 3.4e-28 98.5 12.4 3.6e-28 98.5 12.4 1.1 1 0 0 1 1 1 1 MRN-interacting protein zf-MIZ PF02891.20 OPL07219.1 - 0.027 14.2 3.7 0.027 14.2 3.7 1.7 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger C1_2 PF03107.16 OPL07219.1 - 1.2 9.5 9.8 0.22 11.9 1.4 2.6 1 1 2 3 3 3 0 C1 domain zf-MYND PF01753.18 OPL07220.1 - 2.4e-08 33.9 12.3 4.3e-08 33.1 12.3 1.5 1 0 0 1 1 1 1 MYND finger fn3 PF00041.21 OPL07221.1 - 1.4e-08 34.9 0.3 1.3e-05 25.5 0.1 2.7 2 1 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 OPL07221.1 - 0.00073 20.1 0.4 0.04 14.5 0.1 2.1 1 1 1 2 2 2 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 OPL07221.1 - 0.024 15.2 0.1 1.2 9.7 0.0 2.2 1 1 1 2 2 2 0 PhoD-like phosphatase, N-terminal domain Methyltransf_1N PF02870.15 OPL07221.1 - 0.091 13.6 0.0 22 5.9 0.0 2.2 1 1 1 2 2 2 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain DUF3546 PF12066.8 OPL07222.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3546) Vac7 PF12751.7 OPL07224.1 - 0.018 14.5 1.0 0.018 14.5 1.0 1.0 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 PIG-U PF06728.13 OPL07226.1 - 1.3e-21 77.1 10.2 1.5e-21 76.9 10.2 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Mannosyl_trans PF05007.13 OPL07226.1 - 0.0054 16.6 2.6 0.007 16.3 2.6 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) FYVE PF01363.21 OPL07227.1 - 1e-18 67.2 13.7 1.4e-18 66.8 13.7 1.2 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 OPL07227.1 - 0.0067 16.6 9.8 0.01 16.1 9.8 1.2 1 0 0 1 1 1 1 FYVE-type zinc finger zf-AN1 PF01428.16 OPL07227.1 - 0.36 11.0 10.7 0.25 11.6 5.0 2.2 1 1 1 2 2 2 0 AN1-like Zinc finger zf-B_box PF00643.24 OPL07227.1 - 0.38 11.0 11.1 0.32 11.2 6.4 2.6 2 1 0 2 2 2 0 B-box zinc finger DUF2318 PF10080.9 OPL07227.1 - 0.5 10.5 10.2 5.9 7.1 10.2 2.1 1 1 0 1 1 1 0 Predicted membrane protein (DUF2318) C1_1 PF00130.22 OPL07227.1 - 3 7.8 13.8 3.2 7.7 8.7 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 OPL07227.1 - 4.6 7.6 13.2 0.79 10.1 7.6 2.1 1 1 1 2 2 2 0 C1 domain TPMT PF05724.11 OPL07228.1 - 3.5e-31 108.6 0.0 4.6e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) DUF5423 PF17461.2 OPL07230.1 - 0.072 11.9 1.1 0.077 11.8 1.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) AAA_5 PF07728.14 OPL07231.1 - 0.022 14.8 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) EGF PF00008.27 OPL07234.1 - 1.5e-08 34.8 53.0 0.00024 21.3 4.3 5.8 4 2 0 5 5 5 3 EGF-like domain EGF_2 PF07974.13 OPL07234.1 - 1.8e-08 34.6 56.1 0.0015 18.8 10.3 5.6 4 1 0 4 4 4 3 EGF-like domain hEGF PF12661.7 OPL07234.1 - 0.00075 20.0 48.9 0.014 16.0 4.8 7.5 6 2 1 7 7 7 4 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 OPL07234.1 - 0.0048 17.2 11.4 0.0048 17.2 11.4 4.5 3 1 1 4 4 4 1 Pvs28 EGF domain EGF_3 PF12947.7 OPL07234.1 - 0.015 15.5 3.7 0.015 15.5 3.7 5.7 2 2 2 4 4 4 0 EGF domain EGF_alliinase PF04863.13 OPL07234.1 - 0.093 13.1 0.8 0.093 13.1 0.8 5.1 2 2 3 5 5 5 0 Alliinase EGF-like domain Hydrolase_3 PF08282.12 OPL07234.1 - 0.16 11.7 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Laminin_EGF PF00053.24 OPL07234.1 - 0.44 10.7 54.5 0.33 11.1 16.0 4.7 1 1 3 4 4 4 0 Laminin EGF domain FAM221 PF14753.6 OPL07236.1 - 1e-10 41.5 0.2 1.8e-10 40.8 0.1 1.4 1 1 0 1 1 1 1 Protein FAM221A/B Spectrin PF00435.21 OPL07237.1 - 1.1e-08 35.5 14.4 5.5e-07 30.0 3.0 3.2 2 1 0 3 3 3 1 Spectrin repeat EzrA PF06160.12 OPL07237.1 - 7.3e-05 21.1 3.9 0.0096 14.1 0.9 2.2 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA T3SSipB PF16535.5 OPL07237.1 - 0.00015 22.2 0.7 0.0007 20.1 0.4 2.1 1 1 1 2 2 2 1 Type III cell invasion protein SipB Prominin PF05478.11 OPL07237.1 - 0.0003 18.9 3.9 0.002 16.2 0.7 2.1 1 1 0 2 2 2 1 Prominin FlgN PF05130.12 OPL07237.1 - 0.00059 20.4 5.3 0.00081 19.9 4.6 1.7 1 1 0 1 1 1 1 FlgN protein Spc7 PF08317.11 OPL07237.1 - 0.0025 16.8 2.8 0.0025 16.8 2.8 1.9 1 1 1 2 2 2 1 Spc7 kinetochore protein DUF1664 PF07889.12 OPL07237.1 - 0.0066 16.5 3.1 0.034 14.2 0.7 2.7 1 1 2 3 3 3 1 Protein of unknown function (DUF1664) V-SNARE PF05008.15 OPL07237.1 - 0.0074 16.6 2.0 23 5.5 0.0 3.4 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF4172 PF13776.6 OPL07237.1 - 0.028 14.7 0.5 0.21 12.0 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4172) DnaG_DnaB_bind PF08278.11 OPL07237.1 - 0.029 15.0 2.0 0.051 14.2 0.5 2.0 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding BRE1 PF08647.11 OPL07237.1 - 0.045 13.8 5.4 0.32 11.1 1.8 3.1 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase Sec34 PF04136.15 OPL07237.1 - 0.057 13.3 4.7 6 6.7 0.6 3.1 1 1 2 3 3 3 0 Sec34-like family MIP-T3_C PF17749.1 OPL07237.1 - 0.064 13.2 4.2 0.1 12.6 3.9 1.6 1 1 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region FUSC PF04632.12 OPL07237.1 - 0.085 11.4 1.7 0.098 11.2 1.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ATP-synt_F6 PF05511.11 OPL07237.1 - 0.094 13.1 0.6 1.7 9.1 0.1 2.7 1 1 1 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 Bacillus_HBL PF05791.11 OPL07237.1 - 0.12 12.2 7.6 0.13 12.1 1.5 2.5 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) FlaF PF07309.11 OPL07237.1 - 0.12 12.4 1.4 0.72 9.9 0.2 2.3 2 0 0 2 2 2 0 Flagellar protein FlaF Mobilization_B PF17511.2 OPL07237.1 - 0.12 12.7 1.3 0.22 11.9 0.3 1.9 2 1 0 2 2 2 0 Mobilization protein B Laminin_II PF06009.12 OPL07237.1 - 0.16 12.0 4.9 4.1 7.4 0.5 2.5 2 1 0 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 OPL07237.1 - 0.21 11.9 6.3 8.3 6.8 0.3 3.2 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4404 PF14357.6 OPL07237.1 - 0.44 11.2 10.4 13 6.5 0.1 3.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4404) DUF349 PF03993.12 OPL07237.1 - 0.55 10.6 3.6 14 6.0 0.8 3.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) ZapB PF06005.12 OPL07237.1 - 0.63 10.5 5.3 0.59 10.6 2.0 2.5 1 1 1 2 2 2 0 Cell division protein ZapB TMPIT PF07851.13 OPL07237.1 - 0.72 9.0 4.5 2.2 7.5 0.6 2.0 1 1 1 2 2 2 0 TMPIT-like protein FIVAR PF07554.13 OPL07237.1 - 1 10.2 9.3 12 6.7 0.2 3.8 4 2 1 5 5 3 0 FIVAR domain YabA PF06156.13 OPL07237.1 - 1.3 9.7 4.3 3.3 8.4 0.7 2.8 1 1 2 3 3 3 0 Initiation control protein YabA DUF948 PF06103.11 OPL07237.1 - 2.1 8.6 3.8 21 5.5 2.7 3.1 1 1 0 2 2 1 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 OPL07237.1 - 8.2 7.0 8.6 50 4.4 3.9 2.7 1 1 1 2 2 2 0 Apg6 coiled-coil region COesterase PF00135.28 OPL07239.1 - 0.0018 17.3 0.0 0.29 10.0 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family EGF_CA PF07645.15 OPL07241.1 - 5.9e-09 36.0 8.0 9.3e-09 35.4 8.0 1.3 1 0 0 1 1 1 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 OPL07241.1 - 1.8e-05 24.9 7.8 3.4e-05 24.0 7.8 1.5 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF PF00008.27 OPL07241.1 - 8.9e-05 22.7 6.2 0.00017 21.8 6.2 1.4 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 OPL07241.1 - 0.002 18.7 1.8 0.002 18.7 1.8 2.1 1 1 1 2 2 2 1 Human growth factor-like EGF cEGF PF12662.7 OPL07241.1 - 0.0028 17.6 0.1 0.007 16.3 0.1 1.7 1 0 0 1 1 1 1 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 OPL07241.1 - 0.0039 17.5 6.5 0.0063 16.8 6.5 1.4 1 0 0 1 1 1 1 Pvs28 EGF domain Ldl_recept_b PF00058.17 OPL07241.1 - 0.0044 17.5 0.0 0.0095 16.4 0.0 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor repeat class B EGF_3 PF12947.7 OPL07241.1 - 0.0072 16.5 9.7 0.03 14.5 9.7 1.9 1 1 0 1 1 1 1 EGF domain DUF5050 PF16472.5 OPL07241.1 - 0.024 13.9 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) EGF_MSP1_1 PF12946.7 OPL07241.1 - 0.4 10.8 5.8 0.73 9.9 5.8 1.4 1 0 0 1 1 1 0 MSP1 EGF domain 1 Nucleos_tra2_C PF07662.13 OPL07242.1 - 3.4e-43 147.9 0.5 4.3e-43 147.6 0.5 1.1 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Calx-beta PF03160.14 OPL07243.1 - 1.6e-25 89.2 9.4 3e-19 69.0 0.6 2.3 3 0 0 3 3 3 2 Calx-beta domain PP1_inhibitor PF05361.12 OPL07243.1 - 0.088 12.8 0.2 0.13 12.3 0.2 1.2 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor Reprolysin PF01421.19 OPL07247.1 - 6.1e-17 62.2 0.1 6.5e-17 62.1 0.1 1.1 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.6 OPL07247.1 - 0.01 16.3 0.0 0.012 16.2 0.0 1.1 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 OPL07247.1 - 0.056 13.6 0.0 0.062 13.5 0.0 1.0 1 0 0 1 1 1 0 Metallo-peptidase family M12 Endonuc-PvuII PF09225.10 OPL07248.1 - 0.034 13.9 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease PvuII XPB_DRD PF18458.1 OPL07248.1 - 0.17 11.8 0.1 13 5.7 0.1 2.4 1 1 0 2 2 2 0 Xeroderma pigmentosum group B helicase damage recognition domain RVT_N PF13655.6 OPL07253.1 - 0.17 12.1 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of reverse transcriptase Big_9 PF17963.1 OPL07254.1 - 0.0023 18.6 0.5 0.13 13.0 1.4 2.6 2 1 0 2 2 2 1 Bacterial Ig domain Cadherin_4 PF17803.1 OPL07254.1 - 0.0068 17.0 1.8 0.03 14.9 1.8 2.0 1 1 0 1 1 1 1 Bacterial cadherin-like domain Cadherin_3 PF16184.5 OPL07254.1 - 0.099 12.6 2.3 1.7 8.6 2.3 2.1 1 1 0 1 1 1 0 Cadherin-like DUF5629 PF18629.1 OPL07254.1 - 0.15 12.6 0.0 0.22 12.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5629) VWC PF00093.18 OPL07255.1 - 0.0053 17.0 14.9 0.0073 16.6 14.9 1.2 1 0 0 1 1 1 1 von Willebrand factor type C domain Ion_trans PF00520.31 OPL07257.1 - 2.8e-07 30.0 0.1 3.4e-07 29.8 0.1 1.1 1 0 0 1 1 1 1 Ion transport protein DUF5305 PF17231.2 OPL07257.1 - 0.14 11.6 0.1 0.27 10.6 0.1 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5305) CRIC_ras_sig PF10534.9 OPL07259.1 - 2.6e-23 82.0 1.4 3.8e-23 81.5 1.4 1.2 1 0 0 1 1 1 1 Connector enhancer of kinase suppressor of ras SAM_1 PF00536.30 OPL07259.1 - 1.4e-10 41.4 0.9 3.7e-10 40.1 0.4 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 OPL07259.1 - 1.1e-08 35.1 0.7 1.2e-07 31.7 0.2 2.5 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) MFS_1 PF07690.16 OPL07261.1 - 6.4e-05 22.0 0.5 6.6e-05 22.0 0.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3429 PF11911.8 OPL07261.1 - 0.01 16.1 0.3 0.057 13.7 0.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3429) DUF3054 PF11255.8 OPL07261.1 - 0.039 14.5 0.1 0.046 14.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3054) Glyco_hydro_9 PF00759.19 OPL07263.1 - 1.1e-12 48.2 0.6 1.2e-12 48.0 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 CTP_transf_1 PF01148.20 OPL07264.1 - 0.0032 17.3 1.1 0.0046 16.8 1.1 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family EzrA PF06160.12 OPL07265.1 - 0.0002 19.7 9.9 0.0008 17.7 9.9 1.7 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA COG6 PF06419.11 OPL07265.1 - 0.00023 19.5 3.1 0.00023 19.5 3.1 1.5 1 1 0 1 1 1 1 Conserved oligomeric complex COG6 BRE1 PF08647.11 OPL07265.1 - 0.00059 19.9 12.0 0.00076 19.5 9.0 2.5 1 1 1 2 2 2 1 BRE1 E3 ubiquitin ligase RE_MjaI PF09568.10 OPL07265.1 - 0.0009 19.1 0.9 0.0021 17.9 0.1 1.9 1 1 0 1 1 1 1 MjaI restriction endonuclease RmuC PF02646.16 OPL07265.1 - 0.0015 17.7 11.3 0.033 13.3 2.9 2.4 2 1 1 3 3 2 2 RmuC family CCDC144C PF14915.6 OPL07265.1 - 0.0021 17.3 6.1 0.0037 16.4 6.1 1.3 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region Filament PF00038.21 OPL07265.1 - 0.0047 16.5 8.6 0.024 14.2 2.0 2.4 1 1 2 3 3 3 2 Intermediate filament protein ATG16 PF08614.11 OPL07265.1 - 0.006 16.8 4.0 0.006 16.8 4.0 2.3 2 1 1 3 3 2 1 Autophagy protein 16 (ATG16) MnmE_helical PF12631.7 OPL07265.1 - 0.0079 16.4 4.7 0.013 15.6 4.7 1.4 1 1 0 1 1 1 1 MnmE helical domain SKA2 PF16740.5 OPL07265.1 - 0.0081 15.9 4.0 1.6 8.5 0.1 2.8 2 2 0 2 2 2 1 Spindle and kinetochore-associated protein 2 Laminin_I PF06008.14 OPL07265.1 - 0.0098 15.6 7.4 0.032 13.9 7.4 1.8 1 1 0 1 1 1 1 Laminin Domain I HCMV_UL139 PF12507.8 OPL07265.1 - 0.01 16.2 0.6 0.056 13.8 0.3 2.2 1 1 1 2 2 2 1 Human Cytomegalovirus UL139 protein Spc7 PF08317.11 OPL07265.1 - 0.011 14.7 8.1 0.023 13.6 2.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4472 PF14739.6 OPL07265.1 - 0.016 16.0 2.4 0.016 16.0 2.4 2.7 2 1 1 3 3 2 0 Domain of unknown function (DUF4472) Rab5-bind PF09311.11 OPL07265.1 - 0.016 14.6 6.4 0.032 13.6 5.4 1.9 1 1 0 1 1 1 0 Rabaptin-like protein STAT_alpha PF01017.20 OPL07265.1 - 0.016 15.1 5.9 0.12 12.3 2.9 2.5 1 1 1 2 2 2 0 STAT protein, all-alpha domain CENP-H PF05837.12 OPL07265.1 - 0.017 15.6 11.8 0.043 14.2 3.7 2.9 1 1 2 3 3 3 0 Centromere protein H (CENP-H) Methyltransf_14 PF08484.11 OPL07265.1 - 0.022 14.6 1.1 0.074 12.9 0.2 2.2 2 1 0 2 2 2 0 C-methyltransferase C-terminal domain Med9 PF07544.13 OPL07265.1 - 0.023 14.8 3.3 0.096 12.8 1.6 2.7 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF1351 PF07083.11 OPL07265.1 - 0.024 14.4 7.6 0.065 13.0 7.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1351) CENP-F_leu_zip PF10473.9 OPL07265.1 - 0.03 14.3 1.8 0.03 14.3 1.8 2.2 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V_ATPase_I PF01496.19 OPL07265.1 - 0.036 12.0 6.9 0.043 11.7 6.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF724 PF05266.14 OPL07265.1 - 0.042 13.7 10.2 0.061 13.1 3.7 2.3 2 1 1 3 3 2 0 Protein of unknown function (DUF724) ZapB PF06005.12 OPL07265.1 - 0.05 14.1 0.1 0.05 14.1 0.1 2.4 3 0 0 3 3 2 0 Cell division protein ZapB DUF3450 PF11932.8 OPL07265.1 - 0.052 12.8 3.9 0.097 12.0 2.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) GAS PF13851.6 OPL07265.1 - 0.1 11.9 10.2 0.063 12.6 3.5 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Latarcin PF10279.9 OPL07265.1 - 0.11 13.0 6.8 1.2 9.6 4.9 2.8 1 1 1 2 2 2 0 Latarcin precursor LPP PF04728.13 OPL07265.1 - 0.11 12.9 6.0 0.17 12.3 0.5 3.2 1 1 2 3 3 3 0 Lipoprotein leucine-zipper DUF1664 PF07889.12 OPL07265.1 - 0.13 12.3 10.3 0.16 12.0 3.3 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 OPL07265.1 - 0.17 11.9 9.8 0.16 12.0 1.1 2.7 2 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein Prominin PF05478.11 OPL07265.1 - 0.19 9.6 6.9 0.27 9.1 6.9 1.2 1 0 0 1 1 1 0 Prominin DUF2203 PF09969.9 OPL07265.1 - 0.21 12.3 10.9 0.68 10.7 0.6 2.5 2 1 1 3 3 2 0 Uncharacterized conserved protein (DUF2203) Lectin_N PF03954.14 OPL07265.1 - 0.22 11.2 7.1 1.8 8.3 3.0 2.2 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF5082 PF16888.5 OPL07265.1 - 0.24 11.7 8.0 0.46 10.8 8.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Laminin_II PF06009.12 OPL07265.1 - 0.24 11.4 9.6 5.8 6.9 8.9 2.5 1 1 0 1 1 1 0 Laminin Domain II Tup_N PF08581.10 OPL07265.1 - 0.26 11.6 6.3 2.2 8.7 1.0 2.8 1 1 2 3 3 3 0 Tup N-terminal COG2 PF06148.11 OPL07265.1 - 0.26 11.4 7.0 2.6 8.1 1.4 2.5 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TMPIT PF07851.13 OPL07265.1 - 0.27 10.4 9.8 0.3 10.3 7.1 1.9 1 1 1 2 2 2 0 TMPIT-like protein GIT_CC PF16559.5 OPL07265.1 - 0.29 11.0 5.0 9 6.2 0.0 3.3 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.15 OPL07265.1 - 0.3 10.9 5.9 1 9.2 0.0 3.2 2 2 1 3 3 3 0 Septum formation initiator Fib_alpha PF08702.10 OPL07265.1 - 0.32 11.2 11.1 0.98 9.6 7.7 2.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family MCPsignal PF00015.21 OPL07265.1 - 0.33 10.8 6.7 0.72 9.7 0.6 2.4 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Bacillus_HBL PF05791.11 OPL07265.1 - 0.42 10.4 9.3 2.3 8.0 2.2 2.4 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) PI_PP_I PF18363.1 OPL07265.1 - 0.46 10.7 3.5 14 6.0 1.0 2.8 1 1 2 3 3 3 0 Phosphoinositide phosphatase insertion domain TACC_C PF05010.14 OPL07265.1 - 0.56 10.0 11.1 3.4 7.4 0.3 2.3 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal APG6_N PF17675.1 OPL07265.1 - 0.66 10.5 3.9 9.7 6.7 3.9 2.5 1 1 0 1 1 1 0 Apg6 coiled-coil region YabA PF06156.13 OPL07265.1 - 0.73 10.5 12.4 0.46 11.2 3.4 2.9 1 1 1 2 2 2 0 Initiation control protein YabA FliD_N PF02465.18 OPL07265.1 - 0.82 10.4 6.5 14 6.4 6.4 2.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus TMF_DNA_bd PF12329.8 OPL07265.1 - 0.82 9.7 9.2 3.1 7.9 1.5 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding NPV_P10 PF05531.12 OPL07265.1 - 0.82 10.2 5.1 9.7 6.7 0.1 3.0 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Cnn_1N PF07989.11 OPL07265.1 - 0.94 9.7 9.2 0.34 11.1 3.8 2.8 2 2 2 4 4 4 0 Centrosomin N-terminal motif 1 Fez1 PF06818.15 OPL07265.1 - 1.3 9.4 13.0 6.4 7.2 13.0 2.0 1 1 0 1 1 1 0 Fez1 DUF948 PF06103.11 OPL07265.1 - 2.7 8.3 6.8 5.6 7.3 1.5 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) UPF0242 PF06785.11 OPL07265.1 - 3.5 7.7 13.4 0.15 12.1 2.4 2.4 2 1 1 3 3 2 0 Uncharacterised protein family (UPF0242) N-terminus XhlA PF10779.9 OPL07265.1 - 4.2 7.6 9.2 1.7 8.9 3.9 2.7 1 1 2 3 3 3 0 Haemolysin XhlA DUF4201 PF13870.6 OPL07265.1 - 5.5 6.7 14.9 0.17 11.6 5.9 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) Filament PF00038.21 OPL07266.1 - 0.003 17.2 13.6 0.0041 16.7 13.7 1.3 1 1 0 1 1 1 1 Intermediate filament protein DUF3450 PF11932.8 OPL07266.1 - 0.015 14.6 6.0 0.019 14.3 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Jnk-SapK_ap_N PF09744.9 OPL07266.1 - 0.017 15.4 10.7 0.022 15.0 10.7 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 OPL07266.1 - 0.12 12.2 8.9 0.15 11.8 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMF_DNA_bd PF12329.8 OPL07266.1 - 0.79 9.8 17.9 12 6.0 6.0 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 OPL07266.1 - 0.81 9.5 10.8 0.64 9.8 1.3 2.2 1 1 1 2 2 2 0 Septum formation initiator ARD PF03079.14 OPL07266.1 - 1 9.5 7.2 1.3 9.2 7.2 1.1 1 0 0 1 1 1 0 ARD/ARD' family V_ATPase_I PF01496.19 OPL07266.1 - 1.2 7.0 9.4 1.2 6.9 9.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family M PF02370.16 OPL07266.1 - 1.5 9.6 7.4 22 6.1 1.5 3.1 2 0 0 2 2 2 0 M protein repeat HALZ PF02183.18 OPL07266.1 - 2.7 8.3 15.2 3.9 7.8 1.8 4.0 2 1 2 4 4 4 0 Homeobox associated leucine zipper CENP-H PF05837.12 OPL07266.1 - 3.3 8.2 12.4 8.7 6.8 12.2 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Fzo_mitofusin PF04799.13 OPL07266.1 - 3.6 7.1 9.5 9 5.8 9.6 1.6 1 1 0 1 1 1 0 fzo-like conserved region XhlA PF10779.9 OPL07266.1 - 4.2 7.6 15.1 0.28 11.4 5.7 2.7 1 1 2 3 3 3 0 Haemolysin XhlA ZapB PF06005.12 OPL07266.1 - 4.9 7.7 17.0 0.3 11.6 6.2 2.5 2 1 1 3 3 3 0 Cell division protein ZapB Spc24 PF08286.11 OPL07266.1 - 5.3 7.3 14.5 16 5.8 5.9 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 bZIP_1 PF00170.21 OPL07266.1 - 6.2 7.0 17.1 0.16 12.1 3.3 2.8 1 1 2 3 3 3 0 bZIP transcription factor Ank_4 PF13637.6 OPL07268.1 - 2.4e-17 63.1 2.5 5.5e-09 36.4 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL07268.1 - 1.1e-15 57.9 0.3 2.1e-15 57.1 0.3 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 OPL07268.1 - 1.7e-12 47.2 1.1 0.00057 20.2 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 OPL07268.1 - 4e-12 46.1 0.4 3.6e-08 33.5 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL07268.1 - 2e-10 40.0 0.1 0.0068 16.8 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat AAA_19 PF13245.6 OPL07268.1 - 0.11 12.8 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain VWC PF00093.18 OPL07270.1 - 3.7e-34 116.8 132.4 1.2e-07 32.0 18.2 6.1 6 0 0 6 6 6 6 von Willebrand factor type C domain Pacifastin_I PF05375.13 OPL07270.1 - 7.1e-06 25.7 92.2 0.003 17.2 8.2 7.7 7 0 0 7 7 7 5 Pacifastin inhibitor (LCMII) TILa PF12714.7 OPL07270.1 - 0.4 10.7 116.9 0.11 12.5 14.3 7.7 2 2 5 8 8 8 0 TILa domain Amnionless PF14828.6 OPL07271.1 - 1.9e-40 139.1 1.2 2.1e-40 138.9 1.2 1.0 1 0 0 1 1 1 1 Amnionless Peptidase_C14 PF00656.22 OPL07272.1 - 1.9e-15 57.5 0.0 2e-15 57.4 0.0 1.0 1 0 0 1 1 1 1 Caspase domain TTD PF12148.8 OPL07272.1 - 0.095 12.6 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Tandem tudor domain within UHRF1 REJ PF02010.15 OPL07275.1 - 7.1e-23 81.1 7.8 8.4e-23 80.9 7.8 1.1 1 0 0 1 1 1 1 REJ domain HopW1-1 PF15457.6 OPL07276.1 - 0.00022 20.6 0.3 0.00032 20.1 0.3 1.1 1 0 0 1 1 1 1 Type III T3SS secreted effector HopW1-1/HopPmaA CDC24 PF06395.11 OPL07276.1 - 0.013 15.8 1.1 0.086 13.1 0.4 2.2 1 1 1 2 2 2 0 CDC24 Calponin Macro PF01661.21 OPL07278.1 - 1.3e-20 73.6 0.1 1.4e-20 73.5 0.1 1.0 1 0 0 1 1 1 1 Macro domain His_binding PF02098.16 OPL07278.1 - 0.13 12.3 0.8 7.2 6.6 0.1 2.0 1 1 1 2 2 2 0 Tick histamine binding protein SEA PF01390.20 OPL07279.1 - 0.0023 18.0 0.2 0.0029 17.7 0.2 1.2 1 0 0 1 1 1 1 SEA domain Tra_M PF05261.11 OPL07279.1 - 0.013 15.5 0.2 0.017 15.1 0.2 1.2 1 0 0 1 1 1 0 TraM protein, DNA-binding Pkinase PF00069.25 OPL07280.1 - 1.3e-15 57.5 0.0 1.6e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL07280.1 - 1.2e-08 34.6 0.0 1.3e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ubiquitin PF00240.23 OPL07285.1 - 5.3e-08 32.5 0.0 1.9e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 OPL07285.1 - 0.01 15.6 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Astacin PF01400.24 OPL07286.1 - 5.6e-06 26.1 0.5 7.1e-06 25.8 0.1 1.4 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Tubulin PF00091.25 OPL07287.1 - 1.4e-60 204.9 0.0 1.7e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 OPL07287.1 - 3.8e-14 52.9 0.1 6.6e-14 52.2 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 OPL07287.1 - 0.00046 19.9 0.0 0.00074 19.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Sushi PF00084.20 OPL07288.1 - 1e-12 48.4 5.7 4.9e-07 30.3 1.4 2.3 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) CUB PF00431.20 OPL07288.1 - 0.0038 17.5 0.0 0.0073 16.6 0.0 1.5 1 0 0 1 1 1 1 CUB domain cEGF PF12662.7 OPL07288.1 - 0.51 10.3 5.6 0.85 9.6 0.4 3.2 3 0 0 3 3 3 0 Complement Clr-like EGF-like C1q PF00386.21 OPL07289.1 - 1.8e-21 76.7 2.5 2.4e-21 76.3 2.5 1.2 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL07289.1 - 0.00064 19.6 0.1 0.00094 19.1 0.1 1.2 1 0 0 1 1 1 1 BclA C-terminal domain AIF-MLS PF14962.6 OPL07289.1 - 1.4 8.9 3.6 2 8.3 1.5 1.9 2 0 0 2 2 2 0 Mitochondria Localisation Sequence Cadherin PF00028.17 OPL07290.1 - 0.0015 18.9 0.1 0.0021 18.5 0.1 1.3 1 1 0 1 1 1 1 Cadherin domain CBM-like PF14683.6 OPL07291.1 - 0.051 13.5 0.0 0.075 12.9 0.0 1.4 1 1 0 1 1 1 0 Polysaccharide lyase family 4, domain III DUF3113 PF11310.8 OPL07291.1 - 0.089 12.7 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) DRMBL PF07522.14 OPL07292.1 - 0.35 11.1 3.7 0.12 12.5 0.9 1.7 2 1 0 2 2 2 0 DNA repair metallo-beta-lactamase SHE3 PF17078.5 OPL07292.1 - 0.75 9.5 20.3 1 9.0 8.2 2.2 1 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 Exonuc_VII_L PF02601.15 OPL07292.1 - 2.2 7.8 13.5 2.8 7.4 13.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cluap1 PF10234.9 OPL07292.1 - 3.1 7.1 18.9 3.9 6.8 18.9 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 Sec20 PF03908.13 OPL07292.1 - 6.2 6.8 9.5 5.8 6.9 1.5 2.9 1 1 1 3 3 3 0 Sec20 NAD_binding_1 PF00175.21 OPL07293.1 - 1.5e-07 32.0 0.0 2.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF4813 PF16072.5 OPL07293.1 - 0.00039 20.2 9.4 0.0064 16.2 2.6 2.2 1 1 0 2 2 2 2 Domain of unknown function (DUF4813) Plasmodium_HRP PF05403.11 OPL07293.1 - 0.013 15.3 9.0 0.02 14.7 9.0 1.2 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) Fucosidase_C PF16757.5 OPL07294.1 - 1.4e-20 73.6 0.1 1.5e-20 73.5 0.1 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain AAA_8 PF12780.7 OPL07295.1 - 1.1e-51 175.7 0.0 1.2e-51 175.5 0.0 1.0 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 PMT_4TMC PF16192.5 OPL07296.1 - 1.8e-29 102.7 14.7 2.1e-29 102.6 14.7 1.0 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase AAA_6 PF12774.7 OPL07298.1 - 6.2e-36 124.0 0.1 1.2e-35 123.1 0.1 1.4 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 OPL07298.1 - 1.5e-10 40.8 0.2 2.7e-10 39.9 0.1 1.5 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA PF00004.29 OPL07298.1 - 0.018 15.5 0.0 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 OPL07298.1 - 0.066 13.8 0.0 0.24 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Big_9 PF17963.1 OPL07299.1 - 0.002 18.8 0.9 0.15 12.9 2.0 2.7 2 1 0 2 2 2 1 Bacterial Ig domain Cadherin_4 PF17803.1 OPL07299.1 - 0.0034 18.0 1.5 0.013 16.1 1.5 2.0 1 1 0 1 1 1 1 Bacterial cadherin-like domain Cadherin_3 PF16184.5 OPL07299.1 - 0.095 12.7 2.0 1.3 9.1 2.0 2.1 1 1 0 1 1 1 0 Cadherin-like E1-E2_ATPase PF00122.20 OPL07302.1 - 3.8e-19 68.9 0.0 5.1e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Lamprin PF06403.11 OPL07302.1 - 0.098 12.6 0.2 0.27 11.2 0.2 1.8 1 1 0 1 1 1 0 Lamprin PDZ_6 PF17820.1 OPL07302.1 - 0.23 11.4 3.1 19 5.2 0.1 3.4 2 1 1 3 3 3 0 PDZ domain DinI PF06183.13 OPL07302.1 - 1.3 9.5 3.8 65 4.0 0.1 3.3 1 1 2 3 3 3 0 DinI-like family Ank_5 PF13857.6 OPL07303.1 - 1.1e-17 63.9 0.8 1.4e-08 34.8 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL07303.1 - 2.1e-17 63.4 0.3 2.3e-17 63.3 0.3 1.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 OPL07303.1 - 1.8e-15 56.6 4.1 1.6e-06 28.3 0.6 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 OPL07303.1 - 5.9e-14 52.2 1.0 6.4e-06 26.6 0.0 2.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL07303.1 - 8.2e-14 50.4 0.5 5.6e-06 26.3 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat DUF3398 PF11878.8 OPL07304.1 - 0.13 12.7 0.5 1.5 9.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3398) WD40 PF00400.32 OPL07306.1 - 3.7e-05 24.4 0.2 0.0086 16.9 0.0 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Shisa PF13908.6 OPL07308.1 - 0.00066 20.0 0.0 0.00074 19.8 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FAM163 PF15069.6 OPL07308.1 - 0.025 15.0 0.1 0.031 14.7 0.1 1.2 1 0 0 1 1 1 0 FAM163 family TMEM154 PF15102.6 OPL07308.1 - 0.033 14.1 0.0 0.044 13.7 0.0 1.4 1 1 0 1 1 1 0 TMEM154 protein family CD34_antigen PF06365.12 OPL07308.1 - 0.058 13.0 0.0 0.068 12.7 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family ECSCR PF15820.5 OPL07308.1 - 0.086 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Comm PF15957.5 OPL07308.1 - 0.11 12.9 0.1 0.15 12.4 0.1 1.2 1 0 0 1 1 1 0 Commissureless Peptidase_M14 PF00246.24 OPL07309.1 - 2.3e-13 50.6 0.0 2.7e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase DCAF17 PF15802.5 OPL07310.1 - 0.0083 14.9 0.0 0.0092 14.7 0.0 1.1 1 0 0 1 1 1 1 DDB1- and CUL4-associated factor 17 PQQ PF01011.21 OPL07310.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 PQQ enzyme repeat TssO PF17561.2 OPL07312.1 - 0.22 11.6 1.5 0.35 11.0 1.5 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO Cadherin PF00028.17 OPL07313.1 - 2.1e-05 24.9 0.6 0.0018 18.7 0.1 2.1 2 0 0 2 2 2 2 Cadherin domain FAD_binding_3 PF01494.19 OPL07315.1 - 2.2e-09 37.0 0.0 2.2e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 OPL07315.1 - 5.3e-05 22.4 0.0 5.9e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase AAA_7 PF12775.7 OPL07316.1 - 5.2e-56 189.0 0.4 1.1e-41 142.3 0.1 2.4 1 1 1 2 2 2 2 P-loop containing dynein motor region AAA_lid_1 PF17857.1 OPL07316.1 - 2.8e-15 56.3 0.2 6.1e-15 55.2 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 OPL07316.1 - 2.2e-06 27.8 1.7 4.7e-06 26.7 1.7 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain La PF05383.17 OPL07317.1 - 3.1e-11 43.2 0.2 3.1e-11 43.2 0.2 1.5 2 0 0 2 2 2 1 La domain HIT PF01230.23 OPL07319.1 - 2e-13 50.9 0.1 1.1e-12 48.5 0.0 1.8 1 1 1 2 2 2 1 HIT domain DcpS_C PF11969.8 OPL07319.1 - 6.6e-12 45.9 0.0 8.2e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Hormone_recep PF00104.30 OPL07320.1 - 1.8e-16 60.3 2.9 3.1e-16 59.6 2.9 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor FCH PF00611.23 OPL07321.1 - 1.7e-06 28.2 0.0 2.4e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain LZ3wCH PF18517.1 OPL07321.1 - 0.02 15.0 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Leucine zipper with capping helix domain DICT PF10069.9 OPL07321.1 - 0.023 14.5 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Sensory domain in DIguanylate Cyclases and Two-component system DUF4164 PF13747.6 OPL07321.1 - 0.037 14.3 0.7 0.053 13.8 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) DUF1390 PF07150.11 OPL07321.1 - 0.044 13.5 0.1 0.048 13.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1390) RecG_N PF17190.4 OPL07321.1 - 0.048 14.4 0.2 0.059 14.1 0.2 1.2 1 0 0 1 1 1 0 RecG N-terminal helical domain phiKZ_IP PF12699.7 OPL07321.1 - 0.081 12.1 0.9 0.11 11.7 0.9 1.1 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins AAA_7 PF12775.7 OPL07322.1 - 1.7e-42 145.0 0.1 2.1e-42 144.7 0.1 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region RHSP PF07999.11 OPL07322.1 - 0.0003 19.7 0.0 0.00039 19.4 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Dynein_AAA_lid PF17852.1 OPL07322.1 - 0.0014 18.8 0.1 0.003 17.6 0.0 1.6 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain T2SSE PF00437.20 OPL07322.1 - 0.0017 17.4 0.0 0.0021 17.2 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 OPL07322.1 - 0.018 15.3 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 OPL07322.1 - 0.019 14.7 0.0 0.024 14.4 0.0 1.1 1 0 0 1 1 1 0 Sigma-54 interaction domain ResIII PF04851.15 OPL07322.1 - 0.028 14.4 0.0 0.033 14.2 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 OPL07322.1 - 0.12 12.8 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 OPL07322.1 - 0.15 11.9 0.0 0.2 11.6 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Ras PF00071.22 OPL07322.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 Ras family FtsK_SpoIIIE PF01580.18 OPL07322.1 - 0.2 11.0 0.0 0.27 10.6 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family SNAP PF14938.6 OPL07731.1 - 5.6e-05 22.7 4.9 0.015 14.8 0.7 2.1 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 OPL07731.1 - 0.00065 19.6 4.5 0.38 10.9 0.2 4.0 2 1 2 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 OPL07731.1 - 0.011 15.9 7.3 3.6 7.9 0.1 3.2 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 OPL07731.1 - 0.014 15.9 2.8 1.6 9.3 0.1 2.8 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 OPL07731.1 - 0.044 13.9 16.9 12 6.2 0.1 5.9 3 1 2 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 OPL07731.1 - 0.07 13.4 12.3 3.6 8.0 0.3 4.5 2 1 2 5 5 5 0 Tetratricopeptide repeat Clathrin PF00637.20 OPL07731.1 - 0.15 11.9 5.0 1.4 8.8 0.3 2.8 1 1 2 3 3 3 0 Region in Clathrin and VPS TPR_6 PF13174.6 OPL07731.1 - 0.38 11.5 8.9 10 7.0 0.0 4.4 2 2 2 4 4 4 0 Tetratricopeptide repeat DUF357 PF04010.13 OPL07731.1 - 0.45 10.6 2.7 2.2 8.4 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF357) TPR_1 PF00515.28 OPL07731.1 - 0.63 10.0 20.7 18 5.4 0.7 6.3 3 1 1 6 6 6 0 Tetratricopeptide repeat RPN7 PF10602.9 OPL07731.1 - 0.98 9.1 6.6 1.6 8.4 0.4 2.3 1 1 1 2 2 2 0 26S proteasome subunit RPN7 NSF PF02071.20 OPL07731.1 - 1.3 10.1 18.7 74 4.9 0.6 7.2 7 1 1 8 8 7 0 Aromatic-di-Alanine (AdAR) repeat Amino_oxidase PF01593.24 OPL10964.1 - 8.9e-15 54.9 0.0 1.1e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Coilin_N PF15862.5 OPL10964.1 - 0.19 11.5 7.5 0.26 11.1 7.5 1.1 1 0 0 1 1 1 0 Coilin N-terminus Exo_endo_phos PF03372.23 OPL13204.1 - 1.7e-17 63.8 0.0 1.4e-16 60.8 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 OPL13204.1 - 0.078 12.8 0.0 0.23 11.3 0.0 1.8 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase HECT PF00632.25 OPL13426.1 - 1e-28 100.7 0.0 1.1e-28 100.6 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Sec1 PF00995.23 OPL17896.1 - 7e-27 94.9 0.2 7.8e-27 94.7 0.2 1.0 1 0 0 1 1 1 1 Sec1 family EutA PF06277.11 OPL17896.1 - 0.062 12.1 0.1 0.24 10.2 0.0 1.7 1 1 1 2 2 2 0 Ethanolamine utilisation protein EutA SE PF08491.10 OPL17896.1 - 0.069 12.2 0.0 0.19 10.8 0.0 1.6 2 0 0 2 2 2 0 Squalene epoxidase Memo PF01875.17 OPL17896.1 - 0.17 11.0 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Memo-like protein DDE_Tnp_4 PF13359.6 OPL18247.1 - 1e-19 70.8 0.0 1.2e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 OPL18247.1 - 4e-09 36.4 0.0 4.9e-09 36.1 0.0 1.0 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 OPL18247.1 - 1.5e-05 24.8 0.2 1.7e-05 24.5 0.2 1.1 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_2 PF13586.6 OPL18247.1 - 0.0029 17.9 0.0 0.0039 17.5 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain Tnp_22_trimer PF17489.2 OPL19648.1 - 0.72 9.9 3.7 1.1 9.2 0.1 2.8 3 0 0 3 3 3 0 L1 transposable element trimerization domain SRCR PF00530.18 OPL20143.1 - 2e-18 66.7 4.3 8.7e-11 42.2 0.4 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 OPL20143.1 - 0.00045 20.7 0.8 0.00087 19.8 0.8 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 OPL20143.1 - 0.016 15.7 0.1 0.026 15.0 0.1 1.3 1 0 0 1 1 1 0 Hepsin, SRCR domain BDHCT PF08072.11 OPL20145.1 - 0.18 11.9 1.0 0.42 10.7 0.1 2.1 2 0 0 2 2 2 0 BDHCT (NUC031) domain BORA_N PF15280.6 OPL20146.1 - 5.1e-13 49.2 0.1 1.2e-12 48.0 0.1 1.6 1 0 0 1 1 1 1 Protein aurora borealis N-terminus C1q PF00386.21 OPL20147.1 - 8.3e-16 58.4 0.0 1.2e-15 57.9 0.0 1.2 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL20147.1 - 0.044 13.7 0.1 0.069 13.1 0.1 1.3 1 0 0 1 1 1 0 BclA C-terminal domain DZR PF12773.7 OPL20149.1 - 3.6e-11 42.9 19.5 7.7e-08 32.2 14.9 2.3 2 0 0 2 2 2 2 Double zinc ribbon zinc_ribbon_2 PF13240.6 OPL20149.1 - 3.4e-06 26.6 11.9 1.3e-05 24.8 4.1 4.0 3 1 1 4 4 4 3 zinc-ribbon domain zf-ribbon_3 PF13248.6 OPL20149.1 - 2.5e-05 23.5 28.0 0.0019 17.5 5.7 3.4 3 0 0 3 3 3 3 zinc-ribbon domain zinc_ribbon_15 PF17032.5 OPL20149.1 - 0.004 17.9 21.6 0.068 13.9 2.3 3.4 3 0 0 3 3 3 3 zinc-ribbon family IR1-M PF12185.8 OPL20149.1 - 0.02 14.8 0.7 6.6 6.8 0.1 2.6 2 0 0 2 2 2 0 Nup358/RanBP2 E3 ligase domain YhfH PF14149.6 OPL20149.1 - 0.081 12.9 2.4 0.081 12.9 2.4 4.5 4 1 0 4 4 3 0 YhfH-like protein MqsA_antitoxin PF15731.5 OPL20149.1 - 0.31 11.1 14.8 2.6 8.1 5.6 3.5 1 1 3 4 4 4 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA DUF35_N PF12172.8 OPL20149.1 - 0.97 9.4 14.7 1.1 9.2 2.3 3.2 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-NADH-PPase PF09297.11 OPL20149.1 - 1.7 8.3 24.4 0.34 10.6 4.0 4.2 4 1 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain Nudix_N_2 PF14803.6 OPL20149.1 - 3.7 7.5 26.6 2.5 8.1 0.6 4.9 5 1 0 5 5 5 0 Nudix N-terminal GFA PF04828.14 OPL20149.1 - 6.8 7.1 18.0 11 6.4 0.2 3.9 1 1 3 4 4 4 0 Glutathione-dependent formaldehyde-activating enzyme RNase_T PF00929.24 OPL20151.1 - 2.6e-14 54.1 0.0 3.7e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 OPL20151.1 - 2.8e-08 33.9 0.0 3.8e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like RNase_H_2 PF13482.6 OPL20151.1 - 0.058 13.4 0.3 0.69 9.9 0.2 2.5 1 1 1 2 2 2 0 RNase_H superfamily Costars PF14705.6 OPL20153.1 - 2.7e-27 94.7 1.0 2.8e-27 94.7 0.1 1.4 2 0 0 2 2 2 1 Costars EF-hand_6 PF13405.6 OPL20154.1 - 3.1e-15 54.7 14.3 8.5e-07 28.4 0.1 4.2 4 1 1 5 5 5 3 EF-hand domain EF-hand_1 PF00036.32 OPL20154.1 - 1.3e-14 52.5 9.1 5.5e-07 28.7 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 OPL20154.1 - 1.5e-12 47.8 8.1 6.1e-10 39.4 2.7 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 OPL20154.1 - 2.9e-06 26.5 15.5 4.7e-05 22.7 0.6 3.9 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 OPL20154.1 - 0.00014 21.7 4.7 0.0002 21.1 1.1 2.8 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_4 PF12763.7 OPL20154.1 - 0.0027 17.6 0.7 0.0095 15.9 0.8 1.8 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 OPL20154.1 - 0.0039 17.5 2.1 1.3 9.4 0.2 2.9 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Eryth_link_C PF16915.5 OPL20154.1 - 0.073 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Annelid erythrocruorin linker subunit C-terminus FANCL_C PF11793.8 OPL20155.1 - 0.00045 20.4 5.6 0.00081 19.5 5.6 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain PHD PF00628.29 OPL20155.1 - 0.0013 18.5 6.2 0.0029 17.5 6.2 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 OPL20155.1 - 0.0034 17.6 5.4 0.0048 17.1 5.4 1.3 1 0 0 1 1 1 1 PHD-like zinc-binding domain PHD_4 PF16866.5 OPL20155.1 - 0.011 15.9 7.8 0.11 12.6 7.8 2.3 1 1 0 1 1 1 0 PHD-finger zf-HC5HC2H_2 PF13832.6 OPL20155.1 - 0.018 15.2 4.2 0.026 14.7 4.2 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_2 PF13639.6 OPL20155.1 - 0.022 15.1 7.0 0.053 13.9 7.0 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_4 PF14570.6 OPL20155.1 - 0.12 12.1 4.6 3.5 7.5 2.0 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_1 PF14446.6 OPL20155.1 - 0.95 9.4 11.0 0.77 9.7 4.6 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 1 zf-C3HC4_2 PF13923.6 OPL20155.1 - 5.5 6.9 10.8 1.8 8.5 5.5 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SH3_11 PF18103.1 OPL20157.1 - 0.018 15.2 0.3 0.039 14.1 0.3 1.6 1 0 0 1 1 1 0 Retroviral integrase C-terminal SH3 domain DZR PF12773.7 OPL20157.1 - 0.034 14.2 0.4 0.07 13.2 0.4 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 OPL20157.1 - 0.048 13.1 0.8 0.091 12.2 0.8 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 OPL20157.1 - 0.23 11.3 0.8 0.48 10.2 0.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain DUF3435 PF11917.8 OPL20157.1 - 0.27 10.1 4.6 0.4 9.6 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) MNR PF15718.5 OPL20158.1 - 9.5e-13 47.2 0.0 1.2e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Protein moonraker EGF_CA PF07645.15 OPL20159.1 - 1.1e-27 95.9 35.4 9.8e-10 38.5 3.9 3.1 3 0 0 3 3 3 3 Calcium-binding EGF domain cEGF PF12662.7 OPL20159.1 - 1.2e-19 69.9 13.9 2.4e-08 33.7 0.3 4.0 3 0 0 3 3 3 3 Complement Clr-like EGF-like FXa_inhibition PF14670.6 OPL20159.1 - 1.2e-13 51.0 25.6 1.7e-05 25.0 4.4 3.2 2 1 1 3 3 3 3 Coagulation Factor Xa inhibitory site hEGF PF12661.7 OPL20159.1 - 2.2e-10 40.8 37.6 0.00012 22.6 0.7 5.1 5 1 1 6 6 6 3 Human growth factor-like EGF EGF PF00008.27 OPL20159.1 - 8.8e-10 38.7 36.1 0.0021 18.3 4.7 4.1 3 2 0 3 3 3 3 EGF-like domain EGF_3 PF12947.7 OPL20159.1 - 9.1e-09 35.4 23.9 0.00085 19.5 4.4 4.0 2 2 1 3 3 3 3 EGF domain zf-C3HC4_2 PF13923.6 OPL20160.1 - 6.6e-07 29.1 3.4 1e-06 28.5 3.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 OPL20160.1 - 6e-06 26.0 3.4 9.5e-06 25.4 3.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 OPL20160.1 - 7.7e-06 26.0 7.4 7.7e-06 26.0 7.4 1.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 OPL20160.1 - 0.00014 21.8 5.6 0.00024 21.1 5.6 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 OPL20160.1 - 0.00017 21.4 5.1 0.00025 20.8 5.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL20160.1 - 0.00046 20.5 3.8 0.00072 19.8 3.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.6 OPL20160.1 - 0.0015 18.3 5.7 0.0021 17.9 5.2 1.5 1 1 1 2 2 2 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 OPL20160.1 - 0.011 15.7 6.7 0.011 15.7 6.7 1.6 1 1 1 2 2 2 0 zinc-RING finger domain DUF1726 PF08351.11 OPL20161.1 - 0.00068 19.5 0.1 0.0015 18.5 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) Metalloenzyme PF01676.18 OPL20161.1 - 0.17 11.2 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily AIG1 PF04548.16 OPL20162.1 - 3.5e-45 153.9 0.1 3.5e-45 153.9 0.1 1.5 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.23 OPL20162.1 - 0.069 13.2 0.2 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase ABC_tran PF00005.27 OPL20162.1 - 2.8 8.5 5.9 0.29 11.6 0.3 2.2 1 1 0 2 2 2 0 ABC transporter ANF_receptor PF01094.28 OPL20163.1 - 9.2e-08 31.6 0.4 1.1e-05 24.7 0.4 2.0 1 1 0 1 1 1 1 Receptor family ligand binding region DDE_Tnp_IS1595 PF12762.7 OPL20163.1 - 0.035 14.1 0.2 0.043 13.8 0.2 1.1 1 0 0 1 1 1 0 ISXO2-like transposase domain ZT_dimer PF16916.5 OPL20163.1 - 0.076 13.2 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter MFS_1 PF07690.16 OPL20164.1 - 9.8e-07 28.0 2.6 1.1e-06 27.8 2.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 OPL20164.1 - 0.0015 17.4 0.4 0.0017 17.3 0.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter UNC-93 PF05978.16 OPL20164.1 - 0.0047 16.7 0.2 0.0065 16.2 0.2 1.2 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 ArsC PF03960.15 OPL20165.1 - 0.17 11.9 0.0 0.17 11.9 0.0 2.5 3 1 0 3 3 3 0 ArsC family PDZ PF00595.24 OPL20167.1 - 2.4e-12 47.0 0.4 3.7e-12 46.4 0.4 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 OPL20167.1 - 4.9e-09 35.9 0.2 8.5e-09 35.1 0.2 1.4 1 0 0 1 1 1 1 PDZ domain NRho PF16733.5 OPL20167.1 - 0.0012 18.9 0.1 0.002 18.1 0.1 1.3 1 0 0 1 1 1 1 Rhomboid N-terminal domain FAM163 PF15069.6 OPL20170.1 - 0.028 14.9 0.2 0.028 14.9 0.2 1.1 1 0 0 1 1 1 0 FAM163 family Comm PF15957.5 OPL20170.1 - 0.1 12.9 0.1 0.12 12.8 0.1 1.1 1 0 0 1 1 1 0 Commissureless ECSCR PF15820.5 OPL20170.1 - 0.12 12.2 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator TMEM52 PF14979.6 OPL20170.1 - 0.31 10.9 2.7 0.36 10.7 2.3 1.3 1 1 0 1 1 1 0 Transmembrane 52 zf-C2H2 PF00096.26 OPL20172.1 - 0.0046 17.4 2.0 0.14 12.6 0.1 3.3 3 0 0 3 3 3 1 Zinc finger, C2H2 type TF_Zn_Ribbon PF08271.12 OPL20172.1 - 0.024 14.1 3.1 0.024 14.1 3.1 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding DUF1194 PF06707.11 OPL20172.1 - 0.065 12.4 0.1 0.097 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) zf-C2H2_4 PF13894.6 OPL20172.1 - 0.077 13.9 0.1 0.077 13.9 0.1 3.1 4 1 0 4 4 4 0 C2H2-type zinc finger ECSCR PF15820.5 OPL20173.1 - 0.012 15.4 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF3139 PF11337.8 OPL20173.1 - 0.035 14.8 0.0 0.041 14.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Y1_Tnp PF01797.16 OPL20173.1 - 0.089 12.9 0.0 0.098 12.8 0.0 1.1 1 0 0 1 1 1 0 Transposase IS200 like Amino_oxidase PF01593.24 OPL20174.1 - 8.3e-15 55.0 0.1 8.7e-15 54.9 0.1 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Nop14 PF04147.12 OPL20176.1 - 0.42 8.8 6.5 0.55 8.4 6.5 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 OPL20176.1 - 0.97 7.5 10.8 1.4 7.0 10.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi SpoIIIAH PF12685.7 OPL20176.1 - 3.1 7.6 7.1 6.2 6.6 7.1 1.6 1 0 0 1 1 1 0 SpoIIIAH-like protein SDA1 PF05285.12 OPL20176.1 - 3.4 7.0 9.5 5.8 6.2 9.5 1.3 1 0 0 1 1 1 0 SDA1 Astro_capsid_p PF12226.8 OPL20176.1 - 9.4 5.3 8.6 16 4.5 8.6 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RAI16-like PF10257.9 OPL20179.1 - 8e-42 143.4 0.1 8.8e-42 143.3 0.1 1.0 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein MOR2-PAG1_mid PF14228.6 OPL20179.1 - 0.0026 15.5 0.0 0.0026 15.5 0.0 1.1 1 0 0 1 1 1 1 Cell morphogenesis central region PLDc_2 PF13091.6 OPL20180.1 - 3e-08 33.6 0.2 4.6e-08 33.0 0.2 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.22 OPL20180.1 - 1.7e-06 27.9 0.6 3e-06 27.2 0.6 1.4 1 0 0 1 1 1 1 Phospholipase D Active site motif PDEase_I PF00233.19 OPL20186.1 - 2.2e-23 83.2 0.3 2.3e-23 83.2 0.3 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase WD40 PF00400.32 OPL20187.1 - 0.0041 17.9 0.1 0.032 15.1 0.0 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat Phage_term_smal PF05944.12 OPL20187.1 - 0.1 12.6 0.1 0.14 12.1 0.1 1.1 1 0 0 1 1 1 0 Phage small terminase subunit PARP PF00644.20 OPL20188.1 - 6.1e-13 48.8 1.8 1.1e-10 41.5 2.0 2.8 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain DUF4376 PF14301.6 OPL20190.1 - 0.042 14.2 0.1 0.06 13.7 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4376) Fringe PF02434.16 OPL20191.1 - 0.00058 19.4 0.0 0.00072 19.1 0.0 1.1 1 0 0 1 1 1 1 Fringe-like zf-MYST PF17772.1 OPL20191.1 - 0.017 14.8 0.3 0.031 13.9 0.3 1.5 1 0 0 1 1 1 0 MYST family zinc finger domain SPATA24 PF15175.6 OPL20193.1 - 0.078 12.9 0.3 0.1 12.5 0.3 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 AAA_21 PF13304.6 OPL20194.1 - 0.00053 19.9 0.0 0.0016 18.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Pox_VP8_L4R PF04498.12 OPL20194.1 - 0.013 15.1 0.5 0.022 14.4 0.4 1.4 1 1 0 1 1 1 0 Poxvirus nucleic acid binding protein VP8/L4R Sigma70_r1_1 PF03979.14 OPL20194.1 - 0.38 10.8 5.0 0.71 10.0 5.0 1.4 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 DUF4162 PF13732.6 OPL20194.1 - 0.6 10.9 3.5 0.47 11.2 0.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4162) BTB PF00651.31 OPL20196.1 - 1.4e-08 34.9 0.0 2.7e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Death PF00531.22 OPL20197.1 - 9e-06 25.8 0.0 1.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Death domain Ephrin_rec_like PF07699.13 OPL20198.1 - 0.00082 19.1 4.9 0.00082 19.1 4.9 8.3 5 2 2 8 8 8 4 Putative ephrin-receptor like TNFR_c6 PF00020.18 OPL20198.1 - 0.14 12.5 0.2 0.14 12.5 0.2 8.1 6 2 2 8 8 8 0 TNFR/NGFR cysteine-rich region p450 PF00067.22 OPL20199.1 - 1.5e-05 24.0 0.0 1.7e-05 23.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ank_2 PF12796.7 OPL20201.1 - 3.4e-27 94.8 0.0 2e-15 57.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL20201.1 - 1e-22 80.2 0.3 1.2e-06 29.0 0.0 3.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 OPL20201.1 - 1.1e-19 70.0 2.3 0.00033 21.0 1.4 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 OPL20201.1 - 4.1e-19 66.6 0.0 0.0007 19.9 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 OPL20201.1 - 5.6e-16 58.4 0.8 0.00043 20.5 0.0 4.5 1 1 4 5 5 5 4 Ankyrin repeats (many copies) MoaE PF02391.17 OPL20202.1 - 4.6e-09 36.6 0.1 5.4e-09 36.3 0.1 1.1 1 0 0 1 1 1 1 MoaE protein CH_2 PF06294.11 OPL20204.1 - 2.6e-17 62.7 0.1 4.2e-17 62.0 0.1 1.3 1 1 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 OPL20204.1 - 5.3e-06 26.2 0.0 7.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 CAMSAP CH domain FliG_M PF14841.6 OPL20204.1 - 0.00057 20.1 0.7 0.00087 19.5 0.7 1.3 1 0 0 1 1 1 1 FliG middle domain Rhv PF00073.20 OPL20206.1 - 0.03 13.9 0.5 0.036 13.7 0.5 1.1 1 0 0 1 1 1 0 picornavirus capsid protein SPATA48 PF15073.6 OPL20207.1 - 4.1e-07 30.3 0.4 1.1e-06 29.0 0.1 1.7 2 0 0 2 2 2 1 Spermatogenesis-associated protein 48 mit_SMPDase PF14724.6 OPL20208.1 - 9.6e-08 30.5 0.1 1.1e-07 30.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial-associated sphingomyelin phosphodiesterase Complex1_LYR_2 PF13233.6 OPL20209.1 - 0.0056 17.4 0.0 0.01 16.6 0.0 1.4 1 1 0 1 1 1 1 Complex1_LYR-like UTP25 PF06862.12 OPL20210.1 - 3.8e-36 124.9 3.2 2.3e-20 72.8 0.1 2.0 1 1 1 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 SAM_1 PF00536.30 OPL20211.1 - 6.7e-09 36.1 0.1 7.2e-09 36.0 0.1 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 OPL20211.1 - 1e-08 35.2 0.1 1e-08 35.1 0.1 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Methyltransf_25 PF13649.6 OPL20212.1 - 6.1e-08 33.3 0.1 1.7e-07 31.8 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 OPL20212.1 - 1.6e-06 28.7 0.0 3.2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 OPL20212.1 - 2.8e-06 27.2 0.0 4.8e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 OPL20212.1 - 8.5e-06 26.3 0.0 2.3e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 OPL20212.1 - 0.0017 18.2 0.0 0.0032 17.3 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 OPL20212.1 - 0.0077 15.7 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB PCMT PF01135.19 OPL20212.1 - 0.026 14.3 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 OPL20212.1 - 0.034 13.6 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Ig_3 PF13927.6 OPL20215.1 - 9.3e-54 180.0 33.9 1.4e-15 57.7 2.2 4.1 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 OPL20215.1 - 5e-50 167.5 10.0 1.9e-13 50.2 0.1 4.1 4 0 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.25 OPL20215.1 - 2.1e-40 136.8 28.7 2.9e-10 40.2 1.3 4.3 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 OPL20215.1 - 1.2e-30 105.6 28.7 1.5e-08 34.8 2.4 4.1 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 OPL20215.1 - 6.6e-29 100.3 28.5 2.8e-08 33.9 2.9 7.2 4 4 0 4 4 4 4 Immunoglobulin V-set domain Receptor_2B4 PF11465.8 OPL20215.1 - 7.2e-08 32.6 6.9 0.073 13.3 0.1 4.2 2 1 2 4 4 4 3 Natural killer cell receptor 2B4 Ig_6 PF18452.1 OPL20215.1 - 8.9e-07 28.4 0.0 2.4 7.8 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain Ig_5 PF16681.5 OPL20215.1 - 9.2e-06 26.0 5.0 0.99 9.9 0.1 5.5 4 3 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 OPL20215.1 - 9.4e-06 25.6 0.0 0.54 10.3 0.0 4.3 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 OPL20215.1 - 9.8e-05 22.3 8.6 3.6 7.7 0.3 4.7 4 2 0 4 4 4 2 C17orf99 Ig domain Lep_receptor_Ig PF06328.11 OPL20215.1 - 0.00042 20.2 18.3 0.14 12.2 0.3 4.4 4 0 0 4 4 4 3 Ig-like C2-type domain C2-set PF05790.15 OPL20215.1 - 0.0075 16.4 4.9 5.8 7.2 0.0 5.5 7 1 0 7 7 7 1 Immunoglobulin C2-set domain Ig_4 PF16680.5 OPL20215.1 - 0.078 13.3 7.3 5.4 7.3 0.2 5.4 4 4 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.15 OPL20215.1 - 0.78 9.6 16.9 1.1 9.1 1.3 4.4 4 3 0 4 4 4 0 Adenovirus E3 region protein CR1 DUF5470 PF17564.2 OPL20215.1 - 3.1 8.1 21.1 0.37 11.0 1.2 4.5 4 0 0 4 4 4 0 Family of unknown function (DUF5470) Fer4_NifH PF00142.18 OPL20216.1 - 0.071 12.6 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DUF1736 PF08409.11 OPL20217.1 - 0.0011 18.9 0.2 0.002 18.1 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1736) DUF617 PF04759.13 OPL20218.1 - 0.061 13.4 0.0 0.082 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF617 Claudin_3 PF06653.11 OPL20218.1 - 0.85 9.5 9.9 0.2 11.6 1.5 2.1 1 1 0 2 2 2 0 Tight junction protein, Claudin-like Bcl-2 PF00452.19 OPL20219.1 - 7.6e-05 23.3 0.0 0.00014 22.5 0.0 1.4 1 1 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family LURAP PF14854.6 OPL20220.1 - 0.0016 18.4 0.7 0.0025 17.8 0.3 1.6 1 1 0 1 1 1 1 Leucine rich adaptor protein FAM167 PF11652.8 OPL20220.1 - 0.053 14.0 0.5 0.12 12.8 0.5 1.7 1 1 0 1 1 1 0 FAM167 fn3 PF00041.21 OPL20221.1 - 6.8e-09 36.0 5.8 5.1e-07 29.9 0.2 2.5 2 1 0 2 2 2 2 Fibronectin type III domain Interfer-bind PF09294.10 OPL20221.1 - 3e-05 24.3 4.6 0.00012 22.3 1.6 2.3 1 1 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III WAP PF00095.21 OPL20222.1 - 0.0034 17.7 7.1 0.0052 17.2 7.1 1.2 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Cadherin PF00028.17 OPL20224.1 - 3.8e-31 107.4 1.5 1.3e-16 60.8 0.0 3.1 3 0 0 3 3 3 3 Cadherin domain Cadherin_4 PF17803.1 OPL20224.1 - 1e-05 26.0 8.4 0.00011 22.7 0.5 2.8 3 0 0 3 3 3 2 Bacterial cadherin-like domain Cadherin_pro PF08758.11 OPL20224.1 - 0.00066 19.8 0.1 1.8 8.8 0.0 3.0 3 0 0 3 3 3 2 Cadherin prodomain like Cadherin_2 PF08266.12 OPL20224.1 - 0.004 17.0 0.5 1.7 8.5 0.0 3.3 3 1 0 3 3 3 1 Cadherin-like Big_9 PF17963.1 OPL20224.1 - 0.0076 17.0 6.5 0.058 14.2 0.3 3.1 3 0 0 3 3 3 1 Bacterial Ig domain Cadherin_3 PF16184.5 OPL20224.1 - 0.012 15.6 0.4 0.18 11.8 0.0 2.3 2 0 0 2 2 2 0 Cadherin-like FBPase PF00316.20 OPL20224.1 - 0.3 10.5 2.6 11 5.4 0.1 2.3 2 0 0 2 2 2 0 Fructose-1-6-bisphosphatase, N-terminal domain Guanylate_cyc PF00211.20 OPL20225.1 - 2.9e-20 72.6 0.1 3.2e-20 72.5 0.1 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Lectin_C PF00059.21 OPL20226.1 - 1.7e-05 25.5 0.2 5.1e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 Lectin C-type domain Chordopox_A33R PF05966.12 OPL20226.1 - 0.0025 17.1 3.1 0.0028 17.0 3.1 1.1 1 0 0 1 1 1 1 Chordopoxvirus A33R protein UL45 PF05473.12 OPL20226.1 - 0.0049 16.5 1.5 0.0056 16.3 0.1 1.7 1 1 1 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like CW_binding_1 PF01473.20 OPL20226.1 - 0.15 12.4 0.8 0.34 11.3 0.8 1.6 1 0 0 1 1 1 0 Putative cell wall binding repeat UVR PF02151.19 OPL20226.1 - 0.17 11.7 0.3 0.25 11.1 0.3 1.3 1 0 0 1 1 1 0 UvrB/uvrC motif Spectrin PF00435.21 OPL20227.1 - 0.03 14.8 0.7 0.03 14.8 0.7 2.9 2 1 1 3 3 3 0 Spectrin repeat DUF2315 PF10231.9 OPL20227.1 - 0.058 13.5 3.8 8 6.6 1.7 2.5 2 0 0 2 2 2 0 Apoptogenic protein 1 DUF4298 PF14131.6 OPL20227.1 - 0.16 12.0 10.0 17 5.4 0.0 4.7 3 2 2 5 5 5 0 Domain of unknown function (DUF4298) AAA_23 PF13476.6 OPL20227.1 - 0.24 11.9 4.7 0.25 11.8 3.5 1.5 1 1 0 1 1 1 0 AAA domain Utp11 PF03998.13 OPL20227.1 - 0.44 10.4 6.0 0.71 9.8 6.0 1.4 1 1 0 1 1 1 0 Utp11 protein KxDL PF10241.9 OPL20227.1 - 1.3 9.4 8.0 11 6.3 0.3 4.0 4 1 1 5 5 5 0 Uncharacterized conserved protein DUF1497 PF07384.11 OPL20227.1 - 5 7.6 5.9 0.71 10.3 0.5 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1497) KxDL PF10241.9 OPL20228.1 - 0.0025 18.1 7.9 0.0064 16.7 7.9 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein Cor1 PF04803.12 OPL20228.1 - 0.0062 16.8 8.4 0.0064 16.7 7.7 1.4 1 1 0 1 1 1 1 Cor1/Xlr/Xmr conserved region HIP1_clath_bdg PF16515.5 OPL20228.1 - 0.022 15.4 9.1 0.026 15.1 9.1 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2205 PF10224.9 OPL20228.1 - 0.033 14.2 6.8 0.14 12.1 6.8 2.0 1 1 0 1 1 1 0 Short coiled-coil protein Snapin_Pallidin PF14712.6 OPL20228.1 - 0.19 12.2 8.0 2.5 8.6 2.1 2.3 1 1 1 2 2 2 0 Snapin/Pallidin BLOC1_2 PF10046.9 OPL20228.1 - 0.27 11.5 7.3 0.17 12.2 1.0 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AIP3 PF03915.13 OPL20228.1 - 0.41 9.7 10.4 0.45 9.5 10.4 1.0 1 0 0 1 1 1 0 Actin interacting protein 3 TMPIT PF07851.13 OPL20228.1 - 0.49 9.6 8.1 0.55 9.4 8.1 1.0 1 0 0 1 1 1 0 TMPIT-like protein RGS_DHEX PF18148.1 OPL20228.1 - 0.78 9.9 4.8 0.89 9.7 0.7 2.0 1 1 1 2 2 2 0 Regulator of G-protein signalling DHEX domain Exonuc_VII_L PF02601.15 OPL20228.1 - 0.92 9.0 8.0 1 8.9 8.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-H PF05837.12 OPL20228.1 - 2.4 8.6 9.5 0.87 10.0 1.7 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Fibrinogen_C PF00147.18 OPL20229.1 - 8.3e-27 94.4 5.2 9.1e-27 94.3 5.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain WD40 PF00400.32 OPL20230.1 - 2e-08 34.8 0.1 6.1e-05 23.7 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 OPL20230.1 - 0.0014 17.8 0.0 0.0017 17.5 0.0 1.0 1 0 0 1 1 1 1 Coatomer WD associated region PQQ_2 PF13360.6 OPL20230.1 - 0.046 13.3 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 PQQ-like domain SdiA-regulated PF06977.11 OPL20230.1 - 0.048 12.9 0.0 0.38 9.9 0.0 1.9 1 1 1 2 2 2 0 SdiA-regulated Nucleoporin_N PF08801.11 OPL20230.1 - 0.086 11.6 0.0 2.7 6.6 0.0 2.0 1 1 1 2 2 2 0 Nup133 N terminal like fn3 PF00041.21 OPL20231.1 - 1.8e-13 50.7 0.1 2e-08 34.5 0.0 2.1 2 0 0 2 2 2 2 Fibronectin type III domain VWA_2 PF13519.6 OPL20232.1 - 1.2e-07 32.4 0.0 2.8e-07 31.2 0.0 1.6 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 OPL20232.1 - 0.0017 18.7 0.1 0.0036 17.6 0.1 1.6 1 1 0 1 1 1 1 von Willebrand factor type A domain Myosin_N PF02736.19 OPL20233.1 - 4.4e-19 68.0 2.0 6e-19 67.6 2.0 1.2 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_head PF00063.21 OPL20233.1 - 4.8e-06 25.1 0.1 7.1e-06 24.5 0.1 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) TUDOR PF00567.24 OPL20233.1 - 0.0046 17.0 0.1 0.0061 16.6 0.1 1.2 1 0 0 1 1 1 1 Tudor domain PHM7_ext PF12621.8 OPL20233.1 - 0.068 13.3 0.2 0.15 12.3 0.1 1.6 1 1 0 1 1 1 0 Extracellular tail, of 10TM putative phosphate transporter STE PF02200.16 OPL20234.1 - 0.042 14.3 0.3 0.058 13.8 0.3 1.2 1 0 0 1 1 1 0 STE like transcription factor RIC1 PF07064.13 OPL20235.1 - 2.4e-59 200.8 0.4 2.6e-59 200.7 0.4 1.0 1 0 0 1 1 1 1 RIC1 PRESAN PF09687.10 OPL20237.1 - 0.031 14.8 0.0 0.044 14.3 0.1 1.3 1 1 0 1 1 1 0 Plasmodium RESA N-terminal RhoGAP PF00620.27 OPL20238.1 - 8.9e-19 67.8 0.0 1.3e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain BACK PF07707.15 OPL20238.1 - 0.078 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch RRG8 PF17068.5 OPL20239.1 - 0.023 14.1 0.0 0.029 13.8 0.0 1.1 1 0 0 1 1 1 0 Required for respiratory growth protein 8 mitochondrial Tim17 PF02466.19 OPL20240.1 - 1.1e-07 32.1 0.1 1.3e-07 32.0 0.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Hydrolase_4 PF12146.8 OPL20241.1 - 1.6e-07 30.8 0.0 1.9e-07 30.6 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 OPL20241.1 - 3.8e-06 27.7 0.0 4.2e-06 27.5 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 OPL20241.1 - 8.3e-06 25.6 0.0 9.1e-06 25.5 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.12 OPL20241.1 - 3.9e-05 22.8 0.0 4.5e-05 22.6 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_3 PF07859.13 OPL20241.1 - 0.0007 19.5 0.0 0.001 19.0 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 OPL20241.1 - 0.00088 18.8 0.0 0.00098 18.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 OPL20241.1 - 0.0011 17.7 0.1 0.0054 15.5 0.0 1.9 1 1 1 2 2 2 1 Acetyl xylan esterase (AXE1) DUF818 PF05677.12 OPL20241.1 - 0.0027 16.7 0.0 0.0029 16.6 0.0 1.0 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) BAAT_C PF08840.11 OPL20241.1 - 0.0049 16.8 0.0 0.0058 16.6 0.0 1.1 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase_3 PF01764.25 OPL20241.1 - 0.032 14.1 0.0 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 Lipase (class 3) Peptidase_S15 PF02129.18 OPL20241.1 - 0.063 12.9 0.0 0.08 12.5 0.0 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 OPL20241.1 - 0.08 12.5 0.0 0.13 11.8 0.0 1.3 1 1 0 1 1 1 0 Dienelactone hydrolase family PAF-AH_p_II PF03403.13 OPL20241.1 - 0.17 10.3 0.0 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II PGAP1 PF07819.13 OPL20241.1 - 0.19 11.5 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 PGAP1-like protein HEPN_DZIP3 PF18738.1 OPL20242.1 - 1.8e-20 73.1 0.6 9e-19 67.6 0.0 2.7 3 0 0 3 3 3 1 DZIP3/ hRUL138-like HEPN Spc7 PF08317.11 OPL20242.1 - 0.0037 16.2 9.6 0.0037 16.2 9.6 2.2 1 1 1 2 2 2 1 Spc7 kinetochore protein UPF0242 PF06785.11 OPL20242.1 - 0.21 11.6 24.2 38 4.3 24.2 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HrpB7 PF09486.10 OPL20242.1 - 0.49 10.8 4.9 15 5.9 1.8 2.6 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF4407 PF14362.6 OPL20242.1 - 0.7 9.2 11.7 1.4 8.2 11.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 OPL20242.1 - 0.78 9.9 19.1 6 7.0 12.4 2.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) ANAPC16 PF17256.2 OPL20242.1 - 0.8 10.1 3.7 5.8 7.4 0.2 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex, subunit 16 Fez1 PF06818.15 OPL20242.1 - 1.3 9.4 20.9 36 4.7 20.9 2.1 1 1 0 1 1 1 0 Fez1 DUF1759 PF03564.15 OPL20242.1 - 1.3 8.9 8.0 0.32 10.9 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) DUF16 PF01519.16 OPL20242.1 - 3.8 8.0 28.8 0.19 12.3 3.2 3.2 1 1 2 3 3 3 0 Protein of unknown function DUF16 LMBR1 PF04791.16 OPL20242.1 - 4.6 6.0 6.4 5.9 5.7 6.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein SYF2 PF08231.12 OPL20242.1 - 7.1 7.0 14.6 0.16 12.4 4.7 2.1 1 1 1 2 2 2 0 SYF2 splicing factor 2-Hacid_dh PF00389.30 OPL20244.1 - 1.2e-24 86.5 0.0 1.4e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain C2-set_2 PF08205.12 OPL20246.1 - 3.9e-17 62.1 4.5 3e-10 40.0 2.1 3.1 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 OPL20246.1 - 3.8e-10 40.2 4.6 2.7e-05 24.7 3.9 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 OPL20246.1 - 8e-09 35.7 3.1 0.0028 18.0 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL20246.1 - 2.4e-05 24.3 0.1 0.012 15.7 0.3 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 OPL20246.1 - 2.5e-05 24.4 2.7 0.012 15.7 3.5 2.2 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 OPL20246.1 - 0.0001 22.6 0.9 0.00056 20.2 0.6 2.1 2 1 0 2 2 2 1 Immunoglobulin C1-set domain COR PF16095.5 OPL20247.1 - 1.4e-14 54.4 1.8 1.7e-14 54.1 0.5 1.8 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain SPASM PF13186.6 OPL20247.1 - 0.079 13.5 0.9 0.84 10.2 0.0 3.1 4 0 0 4 4 4 0 Iron-sulfur cluster-binding domain Death PF00531.22 OPL20247.1 - 0.12 12.5 0.0 0.42 10.8 0.0 2.0 2 0 0 2 2 2 0 Death domain Phospholip_B PF04916.13 OPL20249.1 - 1.2e-78 265.0 4.7 1.4e-78 264.8 4.7 1.0 1 0 0 1 1 1 1 Phospholipase B Macro PF01661.21 OPL20250.1 - 0.00011 22.2 0.0 0.00018 21.5 0.0 1.4 1 1 0 1 1 1 1 Macro domain Cystatin PF00031.21 OPL20250.1 - 0.043 14.1 0.3 0.064 13.5 0.3 1.2 1 0 0 1 1 1 0 Cystatin domain bPH_3 PF14470.6 OPL20251.1 - 0.026 14.9 0.0 0.056 13.8 0.0 1.6 1 1 0 1 1 1 0 Bacterial PH domain Myosin_TH1 PF06017.13 OPL20251.1 - 0.026 14.2 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding FAT PF02259.23 OPL20252.1 - 0.023 13.9 0.2 0.084 12.1 0.0 1.9 2 1 0 2 2 2 0 FAT domain APO_RNA-bind PF05634.11 OPL20252.1 - 0.047 13.1 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 APO RNA-binding Med10 PF09748.9 OPL20252.1 - 0.05 13.6 0.1 0.089 12.8 0.1 1.5 1 1 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex EGF_CA PF07645.15 OPL20253.1 - 7.7e-45 150.8 71.1 2.8e-11 43.4 8.1 5.1 5 0 0 5 5 5 5 Calcium-binding EGF domain cEGF PF12662.7 OPL20253.1 - 1.9e-29 101.2 39.9 4e-10 39.4 0.4 6.4 6 0 0 6 6 6 5 Complement Clr-like EGF-like FXa_inhibition PF14670.6 OPL20253.1 - 1.3e-23 82.9 72.5 6.6e-09 35.9 6.1 5.6 4 1 1 5 5 5 5 Coagulation Factor Xa inhibitory site EGF PF00008.27 OPL20253.1 - 2.5e-15 56.4 67.4 0.0002 21.6 9.7 5.9 5 1 0 5 5 5 5 EGF-like domain EGF_3 PF12947.7 OPL20253.1 - 1.4e-12 47.6 68.3 1.5e-05 25.0 9.9 6.3 5 1 0 5 5 5 5 EGF domain Plasmod_Pvs28 PF06247.11 OPL20253.1 - 5.1e-09 36.3 50.2 0.011 16.0 4.0 5.7 5 1 0 5 5 5 5 Pvs28 EGF domain hEGF PF12661.7 OPL20253.1 - 2.5e-08 34.2 68.9 0.00012 22.5 10.0 7.7 7 2 0 8 8 8 5 Human growth factor-like EGF TIL PF01826.17 OPL20253.1 - 0.35 11.2 61.9 0.61 10.4 5.4 6.1 3 2 1 4 4 4 0 Trypsin Inhibitor like cysteine rich domain RANK_CRD_2 PF18278.1 OPL20253.1 - 0.41 10.8 0.2 0.41 10.8 0.2 5.5 5 0 0 5 5 5 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 GBP_PSP PF02425.15 OPL20253.1 - 5.3 6.8 14.5 0.61 9.8 1.9 3.8 3 0 0 3 3 3 0 Paralytic/GBP/PSP peptide DUF1479 PF07350.12 OPL20255.1 - 0.029 13.2 0.0 0.032 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) BIR PF00653.21 OPL20257.1 - 1.6e-15 57.5 0.7 1.6e-15 57.5 0.7 2.3 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 OPL20257.1 - 9.2e-13 47.8 8.7 9.2e-13 47.8 8.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL20257.1 - 1.6e-05 24.6 9.0 4e-05 23.4 9.0 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 OPL20257.1 - 0.0006 20.1 9.8 0.0006 20.1 9.8 1.9 2 0 0 2 2 2 1 Ring finger domain UBA PF00627.31 OPL20257.1 - 0.0023 17.8 0.1 0.053 13.4 0.0 2.5 2 0 0 2 2 2 1 UBA/TS-N domain RNA_pol_N PF01194.17 OPL20257.1 - 0.0047 17.2 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit NRho PF16733.5 OPL20257.1 - 0.0092 16.0 2.8 0.024 14.7 2.7 1.8 2 0 0 2 2 2 1 Rhomboid N-terminal domain zf-C3HC4_2 PF13923.6 OPL20257.1 - 0.021 14.7 11.9 0.021 14.7 11.9 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 OPL20257.1 - 0.023 14.7 9.6 0.058 13.4 9.6 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 OPL20257.1 - 2.7 8.2 10.7 2.3 8.5 7.3 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Maf_N PF08383.11 OPL20260.1 - 0.086 12.6 0.2 0.17 11.7 0.2 1.5 1 0 0 1 1 1 0 Maf N-terminal region DUF2398 PF09661.10 OPL20260.1 - 0.16 11.2 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2398) IstB_IS21 PF01695.17 OPL20261.1 - 0.16 11.7 0.0 0.73 9.5 0.0 1.8 1 1 0 2 2 2 0 IstB-like ATP binding protein EF-hand_1 PF00036.32 OPL20262.1 - 1.1e-09 37.1 1.8 1.7e-07 30.3 0.0 2.7 2 1 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 OPL20262.1 - 1.1e-08 34.3 0.1 5e-07 29.1 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 OPL20262.1 - 2.3e-08 33.2 0.6 2.1e-06 27.0 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 OPL20262.1 - 9.6e-08 32.4 0.5 1.8e-07 31.5 0.5 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 OPL20262.1 - 0.00092 19.0 2.5 0.28 11.1 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair DUF5580 PF17743.1 OPL20262.1 - 0.077 11.5 0.0 0.077 11.5 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) SPARC_Ca_bdg PF10591.9 OPL20262.1 - 0.09 13.1 0.1 0.11 12.9 0.1 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region AIG1 PF04548.16 OPL20263.1 - 1.3e-53 181.5 0.0 1.3e-53 181.5 0.0 2.4 1 1 2 3 3 3 1 AIG1 family MMR_HSR1 PF01926.23 OPL20263.1 - 2.5e-10 40.4 2.5 2.7e-10 40.3 0.1 2.2 1 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 OPL20263.1 - 2.7e-05 23.8 0.0 6.9e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 OPL20263.1 - 9.6e-05 22.3 0.2 9.6e-05 22.3 0.2 3.2 3 1 1 4 4 4 1 RsgA GTPase ABC_tran PF00005.27 OPL20263.1 - 0.12 12.8 0.0 0.12 12.8 0.0 2.5 2 1 0 2 2 2 0 ABC transporter DUF4407 PF14362.6 OPL20263.1 - 0.42 9.9 15.4 0.62 9.4 15.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3523 PF12037.8 OPL20263.1 - 2 7.7 30.7 2.9 7.2 30.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) NPAT_C PF15712.5 OPL20263.1 - 3.9 6.0 14.7 5.2 5.6 14.7 1.1 1 0 0 1 1 1 0 NPAT C terminus Jnk-SapK_ap_N PF09744.9 OPL20263.1 - 4.8 7.4 37.9 0.62 10.3 5.0 2.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FGGY_N PF00370.21 OPL20264.1 - 2.3e-09 37.2 0.0 2.9e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain GTP_EFTU PF00009.27 OPL20265.1 - 6e-57 192.3 0.1 6.9e-57 192.1 0.1 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 OPL20265.1 - 4.9e-06 26.6 0.1 7.7e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 OPL20265.1 - 0.00041 19.7 0.0 0.00053 19.4 0.0 1.2 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 OPL20265.1 - 0.0022 17.5 0.0 0.02 14.3 0.0 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 OPL20265.1 - 0.014 14.9 0.1 0.053 13.0 0.1 2.0 2 1 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 OPL20265.1 - 0.075 12.8 0.1 6.7 6.4 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Sex_peptide PF08138.11 OPL20265.1 - 0.21 11.8 0.0 0.32 11.2 0.0 1.2 1 0 0 1 1 1 0 Sex peptide (SP) family VWA PF00092.28 OPL20266.1 - 4.8e-34 118.1 1.0 5.5e-34 117.9 1.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL20266.1 - 1.2e-12 48.4 0.0 1.8e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 OPL20266.1 - 0.0032 16.9 0.0 0.0048 16.3 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 OPL20266.1 - 0.022 14.7 0.0 0.047 13.6 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain MIEAP PF16026.5 OPL20267.1 - 8.8e-12 45.6 0.1 9.8e-12 45.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondria-eating protein Sec23_helical PF04815.15 OPL20267.1 - 0.021 14.6 0.0 0.032 14.0 0.0 1.2 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Mvb12 PF09452.10 OPL20267.1 - 0.039 14.4 0.3 0.053 14.0 0.3 1.3 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 MbeD_MobD PF04899.12 OPL20267.1 - 0.11 12.6 0.2 0.21 11.7 0.2 1.6 1 1 0 1 1 1 0 MbeD/MobD like Fructosamin_kin PF03881.14 OPL20268.1 - 3e-11 43.1 0.0 3.4e-11 42.9 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase Orthopox_B11R PF07033.11 OPL20268.1 - 0.079 12.8 0.2 0.13 12.1 0.2 1.4 1 0 0 1 1 1 0 Orthopoxvirus B11R protein Thioredoxin PF00085.20 OPL20269.1 - 1.7e-13 50.4 0.0 2e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 OPL20269.1 - 0.072 13.5 0.0 0.1 13.1 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain CARD PF00619.21 OPL20270.1 - 2.3e-16 59.6 0.5 3.7e-16 58.9 0.5 1.4 1 0 0 1 1 1 1 Caspase recruitment domain Death PF00531.22 OPL20270.1 - 7.9e-08 32.4 0.1 3.1e-07 30.4 0.0 2.0 2 1 0 2 2 2 1 Death domain MH2 PF03166.14 OPL20270.1 - 0.012 15.8 0.1 0.018 15.3 0.1 1.2 1 0 0 1 1 1 0 MH2 domain DUF305 PF03713.13 OPL20270.1 - 0.028 14.6 0.0 0.044 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF305) MFS_1 PF07690.16 OPL20271.1 - 6.9e-10 38.4 1.3 7.8e-10 38.2 1.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily ThiC-associated PF13667.6 OPL20272.1 - 0.074 12.9 2.1 1.5 8.7 0.1 2.7 3 0 0 3 3 3 0 ThiC-associated domain DHC_N2 PF08393.13 OPL20273.1 - 3.6e-48 164.6 0.9 5.4e-48 164.0 0.9 1.3 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 OPL20273.1 - 7.1e-09 35.1 1.0 1.1e-08 34.4 0.5 1.6 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region Sugar_tr PF00083.24 OPL20274.1 - 3.3e-42 144.9 13.3 3.9e-26 91.9 5.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 OPL20274.1 - 4.1e-06 26.0 15.1 0.0024 16.8 1.9 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_3 PF05977.13 OPL20274.1 - 0.017 13.5 0.7 2 6.7 0.3 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector CdhC PF03598.15 OPL20275.1 - 0.0099 15.8 0.1 0.071 13.0 0.0 1.9 1 1 1 2 2 2 1 CO dehydrogenase/acetyl-CoA synthase complex beta subunit Lipase_GDSL_2 PF13472.6 OPL20275.1 - 0.046 14.1 0.0 0.053 13.9 0.0 1.0 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF3791 PF12668.7 OPL20275.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) Corona_7 PF02398.16 OPL20276.1 - 0.084 13.4 0.0 0.13 12.9 0.0 1.2 1 0 0 1 1 1 0 Coronavirus protein 7 Glyco_hydro_63 PF03200.16 OPL20277.1 - 0.033 12.9 0.0 0.033 12.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain Galactosyl_T PF01762.21 OPL20277.1 - 0.034 13.9 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 Galactosyltransferase HhH-GPD PF00730.25 OPL20278.1 - 2.5e-21 76.2 0.0 4.7e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 OPL20278.1 - 4e-06 26.4 0.0 1.1e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif PAX PF00292.18 OPL20280.1 - 0.00058 19.8 0.1 0.0012 18.8 0.1 1.6 1 0 0 1 1 1 1 'Paired box' domain Ima1_N PF09779.9 OPL20281.1 - 7.3e-28 98.1 8.3 7.3e-28 98.1 8.3 2.0 2 0 0 2 2 2 1 Ima1 N-terminal domain NOB1_Zn_bind PF08772.11 OPL20281.1 - 0.16 12.2 0.2 0.16 12.2 0.2 2.6 3 1 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like Rubredoxin_2 PF18073.1 OPL20281.1 - 2.4 8.0 9.3 0.97 9.2 0.4 3.1 3 0 0 3 3 3 0 Rubredoxin metal binding domain Elf1 PF05129.13 OPL20281.1 - 2.6 8.1 9.7 74 3.5 0.1 3.8 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like IBR PF01485.21 OPL20281.1 - 5 7.4 12.6 0.4 10.9 4.5 2.8 2 2 0 3 3 3 0 IBR domain, a half RING-finger domain PPV_E2_N PF00508.17 OPL20283.1 - 0.0098 15.3 1.7 0.014 14.8 0.5 1.8 2 0 0 2 2 2 1 E2 (early) protein, N terminal YMF19 PF02326.15 OPL20283.1 - 0.75 10.6 8.1 1 10.2 0.2 3.2 2 2 1 3 3 3 0 Plant ATP synthase F0 Mab-21 PF03281.14 OPL20287.1 - 3e-29 102.2 0.4 3.3e-29 102.1 0.4 1.0 1 0 0 1 1 1 1 Mab-21 protein EF-hand_1 PF00036.32 OPL20288.1 - 1.6e-15 55.4 15.2 2.4e-06 26.7 0.6 4.3 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 OPL20288.1 - 1e-13 50.0 7.0 0.0001 22.0 0.2 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 OPL20288.1 - 2.1e-11 44.1 6.8 1.1e-06 29.0 0.2 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 OPL20288.1 - 2.2e-09 37.0 6.3 8e-05 22.4 0.3 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 OPL20288.1 - 8.9e-09 34.5 9.4 1.6e-05 24.2 0.7 3.3 4 0 0 4 4 4 2 EF hand EF-hand_10 PF14788.6 OPL20288.1 - 3.9e-05 23.4 8.5 0.014 15.2 1.5 3.3 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 OPL20288.1 - 0.00026 21.3 3.2 0.027 14.8 0.4 3.1 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 OPL20288.1 - 0.00049 20.4 0.5 1 9.7 0.0 3.7 4 0 0 4 4 4 1 EF-hand domain EF-hand_4 PF12763.7 OPL20288.1 - 0.0034 17.3 3.4 2 8.4 0.2 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand NADPH_Ox PF08414.10 OPL20288.1 - 0.12 12.7 0.6 0.45 10.9 0.2 1.9 2 0 0 2 2 2 0 Respiratory burst NADPH oxidase PRESAN PF09687.10 OPL20288.1 - 1.4 9.5 9.9 3.1 8.4 0.9 2.8 2 2 1 3 3 3 0 Plasmodium RESA N-terminal DUF4598 PF15370.6 OPL20289.1 - 0.086 13.3 0.0 0.1 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) LRR_8 PF13855.6 OPL20290.1 - 2.3e-14 52.9 18.6 3.7e-07 29.8 3.4 3.3 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 OPL20290.1 - 9.2e-13 48.2 22.6 7.4e-08 32.6 3.1 4.0 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 OPL20290.1 - 2.1e-07 30.5 16.4 0.069 13.7 0.8 5.3 5 1 1 6 6 6 4 Leucine Rich Repeat LRR_9 PF14580.6 OPL20290.1 - 0.0011 18.5 7.0 0.028 13.9 2.2 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 OPL20290.1 - 0.0051 16.8 12.9 0.38 10.9 0.1 4.4 5 0 0 5 5 5 2 Leucine Rich repeat Ank_2 PF12796.7 OPL20292.1 - 0.0032 18.0 0.0 0.0052 17.4 0.0 1.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL20292.1 - 0.0038 17.8 0.0 1.6 9.4 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL20292.1 - 0.0087 16.5 0.0 6.1 7.7 0.0 2.8 2 1 0 2 2 2 2 Ankyrin repeat Fibrinogen_C PF00147.18 OPL20293.1 - 3.5e-39 134.9 9.7 4.6e-39 134.5 9.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain NLE PF08154.12 OPL20294.1 - 5.7e-14 52.4 0.4 8.3e-14 51.9 0.4 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 OPL20294.1 - 3.7e-09 37.1 0.1 6.8e-09 36.2 0.1 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 OPL20294.1 - 8.7e-05 21.6 0.0 9.8e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 OPL20294.1 - 0.0018 18.6 0.0 0.0027 17.9 0.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 OPL20294.1 - 0.06 11.9 0.0 0.091 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain RRM_1 PF00076.22 OPL20295.1 - 3.2e-09 36.5 0.0 4.8e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 OPL20295.1 - 0.015 15.4 0.1 0.038 14.1 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif U1snRNP70_N PF12220.8 OPL20295.1 - 0.027 15.1 1.4 0.037 14.7 1.4 1.2 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Cytochrome_P460 PF16694.5 OPL20296.1 - 0.0074 16.6 0.1 0.0084 16.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P460 DUF1811 PF08838.10 OPL20296.1 - 0.042 14.1 0.3 0.068 13.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) WIYLD PF10440.9 OPL20296.1 - 0.047 13.5 0.1 0.15 11.8 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin-binding WIYLD domain CoA_trans PF01144.23 OPL20296.1 - 0.097 12.0 0.0 0.11 11.9 0.0 1.0 1 0 0 1 1 1 0 Coenzyme A transferase AMP-binding_C PF13193.6 OPL20298.1 - 0.12 13.4 0.0 0.15 13.1 0.0 1.3 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain Luteo_P1-P2 PF08467.10 OPL20298.1 - 0.16 11.2 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase HCR PF07111.12 OPL20299.1 - 9.8e-16 57.0 18.3 1.2e-15 56.7 18.3 1.0 1 0 0 1 1 1 1 Alpha helical coiled-coil rod protein (HCR) FAM184 PF15665.5 OPL20299.1 - 2.9e-06 27.2 11.6 2.9e-06 27.2 11.6 2.1 1 1 1 2 2 2 1 Family with sequence similarity 184, A and B SHE3 PF17078.5 OPL20299.1 - 8.5e-06 25.6 13.7 0.00029 20.7 8.9 2.1 1 1 1 2 2 2 2 SWI5-dependent HO expression protein 3 Phage_HK97_TLTM PF06120.11 OPL20299.1 - 0.0016 17.7 13.8 0.0026 17.0 13.8 1.3 1 1 0 1 1 1 1 Tail length tape measure protein Filament PF00038.21 OPL20299.1 - 0.0025 17.5 22.3 0.096 12.3 5.1 3.0 1 1 0 2 2 2 2 Intermediate filament protein GAS PF13851.6 OPL20299.1 - 0.0042 16.5 22.8 0.01 15.2 22.8 1.5 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Tli4_N PF18443.1 OPL20299.1 - 0.015 15.7 1.3 0.032 14.6 1.3 1.5 1 0 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain Baculo_PEP_C PF04513.12 OPL20299.1 - 0.019 15.0 14.4 0.041 13.9 4.5 2.1 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_DNA_bd PF12329.8 OPL20299.1 - 0.022 14.8 7.6 0.022 14.8 7.6 3.8 1 1 1 2 2 1 0 TATA element modulatory factor 1 DNA binding PRKG1_interact PF15898.5 OPL20299.1 - 0.04 14.8 3.8 0.04 14.8 3.8 3.3 1 1 3 4 4 4 0 cGMP-dependent protein kinase interacting domain PspA_IM30 PF04012.12 OPL20299.1 - 0.042 13.4 19.8 0.26 10.8 2.3 2.9 1 1 2 3 3 3 0 PspA/IM30 family Spc7 PF08317.11 OPL20299.1 - 0.048 12.5 25.2 0.012 14.5 9.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein APG6_N PF17675.1 OPL20299.1 - 0.052 14.1 26.6 0.59 10.7 9.3 2.2 1 1 0 2 2 2 0 Apg6 coiled-coil region DUF948 PF06103.11 OPL20299.1 - 0.057 13.7 12.2 0.067 13.5 1.3 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DivIVA PF05103.13 OPL20299.1 - 0.13 12.3 16.6 0.047 13.8 12.8 2.1 1 1 2 3 3 3 0 DivIVA protein DUF3584 PF12128.8 OPL20299.1 - 0.15 9.5 21.4 0.2 9.1 21.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.9 OPL20299.1 - 0.16 12.0 26.6 0.058 13.4 13.0 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 OPL20299.1 - 0.16 10.6 18.0 0.56 8.8 18.0 1.7 1 1 0 1 1 1 0 AAA domain Atg14 PF10186.9 OPL20299.1 - 0.22 10.6 22.5 1.1 8.3 5.8 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 YlqD PF11068.8 OPL20299.1 - 0.26 11.7 24.4 1.3 9.4 12.4 2.1 1 1 1 2 2 2 0 YlqD protein Cep57_CLD_2 PF14197.6 OPL20299.1 - 0.28 11.3 16.4 0.051 13.7 4.9 3.1 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF3818 PF12825.7 OPL20299.1 - 0.3 10.0 10.7 0.41 9.6 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) DUF2203 PF09969.9 OPL20299.1 - 0.31 11.8 12.4 0.56 11.0 0.8 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Laminin_II PF06009.12 OPL20299.1 - 0.33 11.0 14.2 0.1 12.6 2.3 2.3 1 1 1 2 2 2 0 Laminin Domain II Bacillus_HBL PF05791.11 OPL20299.1 - 0.37 10.6 13.7 1.3 8.9 4.4 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) HAUS-augmin3 PF14932.6 OPL20299.1 - 0.38 10.3 22.0 1.1 8.8 3.6 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Fez1 PF06818.15 OPL20299.1 - 0.46 10.9 21.2 1.9 8.9 20.7 1.9 1 1 1 2 2 2 0 Fez1 HemX PF04375.14 OPL20299.1 - 0.47 9.7 21.6 1.2 8.4 11.5 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4200 PF13863.6 OPL20299.1 - 0.52 10.7 24.2 1.4 9.4 9.6 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) ADIP PF11559.8 OPL20299.1 - 0.57 10.3 24.6 0.91 9.6 5.4 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding HrpJ PF07201.11 OPL20299.1 - 0.61 10.4 14.0 5.4 7.3 14.0 2.4 1 1 0 1 1 1 0 HrpJ-like domain MbeD_MobD PF04899.12 OPL20299.1 - 0.62 10.2 7.8 0.95 9.6 0.1 2.5 2 0 0 2 2 2 0 MbeD/MobD like UPF0242 PF06785.11 OPL20299.1 - 0.72 9.9 28.3 0.11 12.6 15.9 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus BRE1 PF08647.11 OPL20299.1 - 0.86 9.7 18.2 0.42 10.7 8.9 2.7 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Fib_alpha PF08702.10 OPL20299.1 - 0.88 9.8 18.2 1.4 9.1 7.4 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family MCC-bdg_PDZ PF10506.9 OPL20299.1 - 1.2 9.2 8.6 0.43 10.6 2.2 3.0 2 2 2 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Macoilin PF09726.9 OPL20299.1 - 1.4 7.4 20.1 1.8 7.0 20.1 1.0 1 0 0 1 1 1 0 Macoilin family HIP1_clath_bdg PF16515.5 OPL20299.1 - 1.4 9.5 23.4 1.4 9.6 6.0 2.7 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2730 PF10805.8 OPL20299.1 - 1.6 8.9 13.6 0.69 10.0 2.6 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) ThrE PF06738.12 OPL20299.1 - 1.9 7.8 4.4 0.36 10.1 0.4 1.7 2 0 0 2 2 2 0 Putative threonine/serine exporter DUF3450 PF11932.8 OPL20299.1 - 2.5 7.3 19.2 5.6e+02 -0.4 10.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF725 PF05267.12 OPL20299.1 - 2.7 8.0 10.2 1.7 8.6 0.8 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF725) DUF1664 PF07889.12 OPL20299.1 - 2.9 7.9 14.3 7.8 6.6 3.6 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) YscO PF07321.12 OPL20299.1 - 3.1 7.8 23.7 4.7 7.1 6.1 2.2 1 1 1 2 2 2 0 Type III secretion protein YscO Sec34 PF04136.15 OPL20299.1 - 3.1 7.7 14.3 0.38 10.6 3.0 2.3 1 1 1 2 2 2 0 Sec34-like family TPR_MLP1_2 PF07926.12 OPL20299.1 - 3.2 7.8 23.0 84 3.2 22.8 2.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF489 PF04356.12 OPL20299.1 - 3.3 7.7 9.0 3.3 7.7 3.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF489) FlxA PF14282.6 OPL20299.1 - 3.3 7.7 25.2 1.9 8.5 5.0 3.4 1 1 2 3 3 3 0 FlxA-like protein LMBR1 PF04791.16 OPL20299.1 - 4.4 6.1 11.4 5.4 5.8 11.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Spc24 PF08286.11 OPL20299.1 - 4.9 7.4 22.0 4 7.7 5.4 3.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ATG16 PF08614.11 OPL20299.1 - 5.1 7.3 27.6 0.14 12.4 6.9 2.2 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 OPL20299.1 - 5.2 7.3 26.7 1.1e+02 3.0 12.5 2.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Exonuc_VII_L PF02601.15 OPL20299.1 - 5.3 6.5 19.4 1.3e+02 2.0 19.4 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit FAM76 PF16046.5 OPL20299.1 - 6 6.1 20.9 14 5.0 20.9 1.5 1 1 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 OPL20299.1 - 6.2 6.1 17.1 28 3.9 12.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 OPL20299.1 - 6.4 5.9 16.0 0.45 9.7 6.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein BST2 PF16716.5 OPL20299.1 - 6.6 7.4 23.8 0.5 11.0 4.6 3.2 1 1 1 3 3 3 0 Bone marrow stromal antigen 2 SlyX PF04102.12 OPL20299.1 - 6.6 7.4 22.5 0.89 10.2 3.1 3.3 1 1 2 3 3 3 0 SlyX DUF724 PF05266.14 OPL20299.1 - 8.2 6.2 20.8 0.85 9.4 5.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) LPP PF04728.13 OPL20299.1 - 9.1 6.8 11.5 2.3 8.7 1.5 3.6 2 2 1 3 3 3 0 Lipoprotein leucine-zipper FUSC PF04632.12 OPL20299.1 - 9.8 4.6 7.6 17 3.7 7.6 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family Kunitz_BPTI PF00014.23 OPL20300.1 - 1.1e-18 67.2 5.3 1.3e-18 66.9 5.3 1.1 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Phage_GP20 PF06810.11 OPL20301.1 - 0.00097 19.0 19.0 0.00097 19.0 19.0 3.6 1 1 3 4 4 4 1 Phage minor structural protein GP20 GIDE PF12483.8 OPL20306.1 - 4.8e-15 55.3 0.0 8.2e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 E3 Ubiquitin ligase zf-C3HC4_3 PF13920.6 OPL20306.1 - 2.4e-13 49.7 12.1 3.8e-13 49.1 12.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL20306.1 - 1.2e-07 31.4 12.0 2.2e-07 30.6 12.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 OPL20306.1 - 1.6e-05 24.8 10.8 2.8e-05 24.0 10.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 OPL20306.1 - 5.9e-05 23.3 13.2 0.00011 22.5 13.2 1.4 1 0 0 1 1 1 1 Ring finger domain SHR3_chaperone PF08229.11 OPL20306.1 - 0.16 10.9 1.0 0.39 9.7 1.0 1.4 1 1 0 1 1 1 0 ER membrane protein SH3 zf-C3HC4_2 PF13923.6 OPL20306.1 - 4.3 7.3 12.9 7.3 6.5 12.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) GST_C_3 PF14497.6 OPL20307.1 - 1.6e-12 47.5 0.0 2.1e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 OPL20307.1 - 2.4e-12 46.9 0.0 3.3e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 OPL20307.1 - 0.0081 16.2 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Keratin_assoc PF09775.9 OPL20308.1 - 8.9e-13 48.0 1.4 1.8e-12 47.0 1.4 1.5 1 1 0 1 1 1 1 Keratinocyte-associated protein 2 TIR PF01582.20 OPL20309.1 - 3.2e-17 62.9 0.1 4e-17 62.6 0.1 1.2 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 OPL20309.1 - 6.9e-10 39.6 0.0 9.2e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.11 OPL20309.1 - 0.017 15.4 0.0 0.026 14.8 0.0 1.3 1 0 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Orthopox_A49R PF06489.11 OPL20309.1 - 0.084 13.1 0.2 0.16 12.2 0.2 1.5 1 1 0 1 1 1 0 Orthopoxvirus A49R protein MscS_porin PF12795.7 OPL20313.1 - 0.0006 19.4 4.6 0.00073 19.2 4.6 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF724 PF05266.14 OPL20313.1 - 0.0084 16.0 5.6 0.0094 15.8 5.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF724) Laminin_I PF06008.14 OPL20313.1 - 0.01 15.5 7.2 0.015 15.0 7.3 1.4 1 1 0 1 1 1 0 Laminin Domain I DUF4515 PF14988.6 OPL20313.1 - 0.025 14.4 2.7 0.025 14.4 2.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) bZIP_1 PF00170.21 OPL20313.1 - 0.041 14.0 10.0 0.78 9.9 2.2 2.4 2 1 0 2 2 2 0 bZIP transcription factor Sas6_CC PF18594.1 OPL20313.1 - 0.12 12.1 6.5 2.7 7.9 0.7 2.5 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain Sec34 PF04136.15 OPL20313.1 - 0.23 11.3 7.0 0.24 11.3 7.0 1.0 1 0 0 1 1 1 0 Sec34-like family KIAA1430 PF13879.6 OPL20313.1 - 0.26 12.1 7.6 0.41 11.4 7.6 1.3 1 0 0 1 1 1 0 KIAA1430 homologue HALZ PF02183.18 OPL20313.1 - 0.3 11.3 12.3 0.47 10.7 4.7 2.8 2 1 0 2 2 2 0 Homeobox associated leucine zipper FapA PF03961.13 OPL20313.1 - 0.51 8.9 5.7 0.57 8.7 5.7 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A ZapB PF06005.12 OPL20313.1 - 0.56 10.7 10.2 0.66 10.5 3.8 2.2 1 1 1 2 2 2 0 Cell division protein ZapB KxDL PF10241.9 OPL20313.1 - 0.72 10.2 10.5 1.2 9.5 6.1 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein UPF0242 PF06785.11 OPL20313.1 - 0.74 9.9 9.3 1.5 8.9 9.3 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 OPL20313.1 - 0.77 10.4 8.9 0.84 10.3 7.2 1.8 1 1 1 2 2 2 0 Initiation control protein YabA Herpes_BLRF2 PF05812.12 OPL20313.1 - 0.78 9.9 6.7 1.4 9.1 1.8 2.0 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein Mto2_bdg PF12808.7 OPL20313.1 - 4.1 7.8 9.0 3.7 7.9 0.4 2.7 2 1 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DivIC PF04977.15 OPL20313.1 - 6.4 6.6 10.3 3.4 7.5 3.3 2.2 1 1 1 2 2 2 0 Septum formation initiator RB_A PF01858.17 OPL20314.1 - 2.2e-28 99.4 0.2 2.4e-28 99.3 0.2 1.0 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain ADK PF00406.22 OPL20315.1 - 7.5e-25 87.8 0.0 8.6e-25 87.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 OPL20315.1 - 5.1e-17 61.6 0.0 7.8e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 OPL20315.1 - 0.00015 22.2 0.0 0.00047 20.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 OPL20315.1 - 0.066 13.8 0.0 0.31 11.6 0.0 1.8 1 1 1 2 2 2 0 AAA domain ZF-HD_dimer PF04770.12 OPL20318.1 - 0.11 12.9 0.0 4.7 7.6 0.0 2.5 1 1 1 2 2 2 0 ZF-HD protein dimerisation region EF-hand_1 PF00036.32 OPL20319.1 - 3.4e-27 91.9 7.6 6.8e-09 34.7 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 OPL20319.1 - 1.1e-26 92.5 5.9 4.1e-14 52.2 0.8 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 OPL20319.1 - 6.4e-25 87.4 0.5 1.2e-16 60.9 0.5 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 OPL20319.1 - 3.5e-17 60.8 5.8 2.4e-08 33.2 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 OPL20319.1 - 8.9e-17 59.8 4.1 0.00012 21.4 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 OPL20319.1 - 7.9e-08 32.5 0.2 0.01 16.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 OPL20319.1 - 7.9e-06 25.8 0.4 0.0052 16.7 0.0 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1103 PF06513.11 OPL20319.1 - 6e-05 22.8 0.1 6.9e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) SPARC_Ca_bdg PF10591.9 OPL20319.1 - 0.00087 19.6 0.0 0.022 15.1 0.0 2.0 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 OPL20319.1 - 0.0011 17.6 0.0 0.0012 17.5 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_11 PF08976.11 OPL20319.1 - 0.0014 19.5 0.0 0.029 15.2 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 OPL20319.1 - 0.027 14.5 0.0 3.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 OPL20319.1 - 0.076 13.1 0.0 0.15 12.2 0.0 1.6 2 1 0 2 2 2 0 Ca2+ insensitive EF hand Utp14 PF04615.13 OPL20321.1 - 8.6e-38 130.4 79.1 2.6e-37 128.9 79.1 1.6 1 1 0 1 1 1 1 Utp14 protein Med11 PF10280.9 OPL20322.1 - 2.2e-09 37.9 0.1 2.8e-09 37.5 0.1 1.1 1 0 0 1 1 1 1 Mediator complex protein DUF3583 PF12126.8 OPL20322.1 - 0.02 14.4 0.1 0.02 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) DUF2408 PF10303.9 OPL20322.1 - 0.11 13.1 0.9 1.2 9.7 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Pkinase_Tyr PF07714.17 OPL20323.1 - 5e-11 42.4 0.0 2.6e-09 36.8 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 OPL20323.1 - 2.7e-07 30.2 0.0 8.3e-06 25.4 0.0 2.0 1 1 0 2 2 2 2 Protein kinase domain EF-hand_1 PF00036.32 OPL20324.1 - 2.5e-38 126.8 8.9 1.1e-09 37.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 OPL20324.1 - 1.2e-32 112.2 1.4 2.7e-15 56.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 OPL20324.1 - 1.2e-28 98.7 8.4 8.1e-13 48.0 0.1 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 OPL20324.1 - 1.4e-27 93.2 6.6 1.7e-09 36.9 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 OPL20324.1 - 5.9e-25 85.6 7.0 8.8e-07 28.1 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 OPL20324.1 - 2e-13 50.4 0.2 3.8e-09 36.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 OPL20324.1 - 2e-06 27.7 0.3 0.018 15.0 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 OPL20324.1 - 2.6e-06 27.7 0.0 0.034 14.4 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 OPL20324.1 - 4.4e-05 23.4 0.0 0.056 13.5 0.0 2.8 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 OPL20324.1 - 5.9e-05 23.9 0.0 0.037 14.9 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 OPL20324.1 - 0.00031 20.9 4.8 0.03 14.5 0.5 3.0 1 1 2 3 3 3 2 Dockerin type I domain EFhand_Ca_insen PF08726.10 OPL20324.1 - 0.00034 20.6 0.5 0.0019 18.3 0.1 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand Caleosin PF05042.13 OPL20324.1 - 0.00054 19.9 1.3 0.62 10.0 0.0 3.7 1 1 2 4 4 4 1 Caleosin related protein DUF1103 PF06513.11 OPL20324.1 - 0.003 17.2 1.0 0.0037 16.9 1.0 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) DUF4497 PF14924.6 OPL20324.1 - 0.0037 17.7 0.0 2.4 8.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4497) RNA_pol_Rpb4 PF03874.16 OPL20324.1 - 0.0051 17.1 0.7 2 8.7 0.1 2.5 3 0 0 3 3 2 1 RNA polymerase Rpb4 DUF3349 PF11829.8 OPL20324.1 - 0.0072 17.1 0.2 2.5 8.9 0.0 2.6 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) dCache_2 PF08269.11 OPL20324.1 - 0.0094 15.2 0.1 0.61 9.2 0.0 2.2 1 1 1 2 2 2 1 Cache domain Poly_export PF02563.16 OPL20324.1 - 0.016 15.4 0.1 1 9.6 0.0 3.1 1 1 1 2 2 2 0 Polysaccharide biosynthesis/export protein MotA_activ PF09114.10 OPL20324.1 - 0.018 15.2 0.3 0.28 11.3 0.0 2.4 1 1 0 2 2 2 0 Transcription factor MotA, activation domain SurA_N_2 PF13623.6 OPL20324.1 - 0.06 13.2 0.7 2.9 7.8 0.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain Fe_hyd_lg_C PF02906.14 OPL20324.1 - 0.079 12.6 0.3 0.22 11.1 0.3 1.7 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain TerB PF05099.13 OPL20324.1 - 0.081 12.9 1.2 0.97 9.4 0.0 2.5 1 1 2 3 3 3 0 Tellurite resistance protein TerB Spore_III_AB PF09548.10 OPL20324.1 - 0.11 12.6 0.3 0.22 11.6 0.3 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) EF-hand_14 PF17959.1 OPL20324.1 - 0.12 12.7 0.1 13 6.2 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain DUF5580 PF17743.1 OPL20324.1 - 0.15 10.6 0.0 0.17 10.4 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) WD40 PF00400.32 OPL20325.1 - 1.3e-13 51.2 11.7 0.018 15.9 0.2 6.7 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 OPL20325.1 - 5.3e-08 33.1 0.1 0.00029 21.1 0.0 3.3 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 OPL20325.1 - 0.0025 16.8 0.1 0.039 12.9 0.1 2.5 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 OPL20325.1 - 0.014 15.3 0.9 5.2 7.1 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 OPL20325.1 - 0.022 14.8 0.0 0.9 9.6 0.0 2.6 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Occludin_ELL PF07303.13 OPL20326.1 - 0.073 13.8 2.3 0.1 13.3 2.3 1.3 1 1 0 1 1 1 0 Occludin homology domain RIC1 PF07064.13 OPL20328.1 - 0.092 12.1 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 RIC1 Laminin_G_2 PF02210.24 OPL20329.1 - 6.5e-22 78.4 1.2 5.2e-13 49.7 0.1 2.2 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 OPL20329.1 - 1.8e-15 57.3 0.1 1.4e-07 31.8 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 OPL20329.1 - 0.0075 16.5 5.6 0.017 15.4 5.6 1.6 1 0 0 1 1 1 1 EGF-like domain TLD PF07534.16 OPL20329.1 - 0.17 12.1 0.7 0.93 9.7 0.1 2.2 1 1 0 2 2 2 0 TLD Cupin_3 PF05899.12 OPL20330.1 - 0.061 13.0 2.1 0.5 10.1 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Tcp10_C PF07202.13 OPL20330.1 - 8.9 6.2 27.2 0.6 10.0 19.0 2.6 1 1 1 2 2 2 0 T-complex protein 10 C-terminus DOCK-C2 PF14429.6 OPL20331.1 - 1.7e-07 31.3 0.0 2.8e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins zf-RanBP PF00641.18 OPL20332.1 - 0.0063 15.8 2.9 0.016 14.6 2.9 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Alpha_E2_glycop PF00943.19 OPL20332.1 - 0.11 11.3 2.0 4.2 6.0 0.3 2.1 1 1 1 2 2 2 0 Alphavirus E2 glycoprotein UCH PF00443.29 OPL20334.1 - 1.3e-34 119.9 0.0 1.5e-34 119.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MFS_1 PF07690.16 OPL20335.1 - 5.6e-06 25.5 0.1 6.4e-06 25.3 0.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Cadherin PF00028.17 OPL20336.1 - 0.001 19.4 0.1 0.0015 18.9 0.1 1.3 1 0 0 1 1 1 1 Cadherin domain Cadherin_2 PF08266.12 OPL20336.1 - 0.11 12.3 0.0 0.42 10.5 0.0 2.0 1 1 0 1 1 1 0 Cadherin-like UCH PF00443.29 OPL20337.1 - 7.6e-17 61.6 0.5 1.1e-16 61.1 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 OPL20337.1 - 1.7e-05 24.6 0.0 3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PP2C PF00481.21 OPL20338.1 - 1e-10 41.7 0.3 1.9e-10 40.9 0.1 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C Kelch_1 PF01344.25 OPL20339.1 - 7.4e-19 67.1 1.1 7.9e-08 31.8 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 OPL20339.1 - 7.1e-12 45.1 0.3 0.00027 20.9 0.0 3.5 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 OPL20339.1 - 1.5e-11 44.3 0.0 3.9e-06 27.0 0.0 2.8 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 OPL20339.1 - 3.5e-10 39.8 3.3 0.014 15.7 0.3 3.5 1 1 2 3 3 3 3 Kelch motif Kelch_5 PF13854.6 OPL20339.1 - 6.8e-09 35.5 0.4 5.1e-05 23.2 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 OPL20339.1 - 2.9e-06 27.0 1.2 0.051 13.6 0.0 3.3 3 0 0 3 3 3 2 Kelch motif zf-C2H2_3 PF13878.6 OPL20339.1 - 0.068 13.0 0.1 0.068 13.0 0.1 2.0 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO TIG PF01833.24 OPL20340.1 - 1.1e-08 35.0 0.7 1.6e-08 34.5 0.7 1.2 1 0 0 1 1 1 1 IPT/TIG domain PWWP PF00855.17 OPL20341.1 - 4.4e-14 52.6 0.1 4.4e-14 52.6 0.1 2.5 3 0 0 3 3 3 1 PWWP domain Prenyltrans PF00432.21 OPL20341.1 - 0.12 12.1 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat LIM PF00412.22 OPL20342.1 - 6e-05 23.2 10.4 9.1e-05 22.6 10.4 1.3 1 0 0 1 1 1 1 LIM domain NT-C2 PF10358.9 OPL20343.1 - 0.062 13.0 0.3 0.11 12.2 0.3 1.3 1 1 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins GBS_Bsp-like PF08481.10 OPL20344.1 - 0.091 12.9 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 GBS Bsp-like repeat MMACHC PF16690.5 OPL20345.1 - 4.1e-89 297.9 0.2 4.7e-89 297.7 0.2 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type C family DUF4105 PF13387.6 OPL20346.1 - 0.00042 20.0 0.1 0.0007 19.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4105) Viral_DNA_Zn_bi PF03728.13 OPL20346.1 - 0.0063 17.1 0.0 0.011 16.3 0.0 1.3 1 0 0 1 1 1 1 Viral DNA-binding protein, zinc binding domain Peptidase_C97 PF05903.14 OPL20346.1 - 0.065 13.1 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain W2 PF02020.18 OPL20346.1 - 0.086 13.0 3.1 0.69 10.1 0.5 2.4 2 1 0 2 2 2 0 eIF4-gamma/eIF5/eIF2-epsilon PTE PF02126.18 OPL20347.1 - 8.8e-59 199.4 0.6 1e-58 199.2 0.6 1.0 1 0 0 1 1 1 1 Phosphotriesterase family Amidohydro_1 PF01979.20 OPL20347.1 - 0.0013 18.1 0.0 0.0015 17.9 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family CD20 PF04103.15 OPL20348.1 - 0.032 14.3 0.2 0.054 13.6 0.2 1.3 1 0 0 1 1 1 0 CD20-like family Myb_CC_LHEQLE PF14379.6 OPL20348.1 - 0.034 13.9 5.7 0.25 11.1 0.5 2.5 2 0 0 2 2 2 0 MYB-CC type transfactor, LHEQLE motif Sh_2 PF17512.2 OPL20348.1 - 0.13 12.1 2.0 0.14 11.9 0.4 1.8 1 1 0 2 2 2 0 Metapneumovirus Small hydrophobic protein BLOC1_2 PF10046.9 OPL20348.1 - 0.21 11.9 4.9 0.22 11.8 1.6 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ERp29 PF07749.12 OPL20349.1 - 0.12 13.3 7.7 1.8 9.5 1.8 2.9 3 0 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF2151 PF10221.9 OPL20351.1 - 0.78 8.3 5.8 0.78 8.3 5.8 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Aa_trans PF01490.18 OPL20352.1 - 1.6e-14 53.5 1.6 1.6e-14 53.4 1.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ubiquitin PF00240.23 OPL20353.1 - 1e-26 92.4 0.2 1.3e-26 92.1 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 OPL20353.1 - 1.4e-12 47.3 0.2 1.6e-12 47.0 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 OPL20353.1 - 0.0022 18.4 0.1 0.01 16.3 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 OPL20353.1 - 0.077 13.4 0.1 0.098 13.0 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 OPL20353.1 - 0.088 13.4 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 OPL20353.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.5 1 1 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain TUDOR PF00567.24 OPL20354.1 - 5.5e-15 55.5 0.2 1.3e-14 54.2 0.1 1.7 2 0 0 2 2 2 1 Tudor domain Agenet PF05641.12 OPL20354.1 - 0.1 13.1 0.1 0.3 11.6 0.0 1.8 2 0 0 2 2 2 0 Agenet domain MTS PF05175.14 OPL20355.1 - 0.043 13.4 0.2 0.11 12.1 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase small domain ETAA1 PF15350.6 OPL20356.1 - 4.3e-13 48.5 45.6 0.0014 17.1 1.2 6.2 5 1 1 6 6 6 6 Ewing's tumour-associated antigen 1 homologue hnRNP_Q_AcD PF18360.1 OPL20356.1 - 0.013 15.4 3.2 61 3.7 0.1 5.3 6 0 0 6 6 6 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain DUF5302 PF17227.2 OPL20356.1 - 0.025 15.6 13.1 2.6 9.1 1.1 4.7 4 0 0 4 4 4 0 Family of unknown function (DUF5302) Malate_DH PF12434.8 OPL20356.1 - 2.4 8.3 7.2 3.4 7.8 0.2 3.8 3 0 0 3 3 3 0 Malate dehydrogenase enzyme Spin-Ssty PF02513.17 OPL20357.1 - 0.00013 21.7 0.1 0.00025 20.7 0.0 1.5 2 0 0 2 2 2 1 Spin/Ssty Family DUF3104 PF11302.8 OPL20357.1 - 0.17 11.6 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Prefoldin_2 PF01920.20 OPL20359.1 - 7.7e-20 70.8 12.4 9.4e-20 70.6 12.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit Vac_Fusion PF02346.16 OPL20359.1 - 0.0029 17.2 0.7 0.079 12.6 0.1 2.3 2 0 0 2 2 2 1 Chordopoxvirus multifunctional envelope protein A27 BAR_3_WASP_bdg PF10456.9 OPL20359.1 - 0.0062 16.0 1.5 0.0072 15.8 1.5 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein Bcr-Abl_Oligo PF09036.10 OPL20359.1 - 0.011 15.7 2.6 0.016 15.2 0.5 2.2 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Prefoldin PF02996.17 OPL20359.1 - 0.015 15.2 12.0 0.13 12.2 5.6 2.7 1 1 1 2 2 2 0 Prefoldin subunit Fib_alpha PF08702.10 OPL20359.1 - 0.02 15.1 8.2 0.035 14.3 8.2 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DHHW PF14286.6 OPL20359.1 - 0.065 12.6 0.1 0.076 12.3 0.1 1.1 1 0 0 1 1 1 0 DHHW protein Prefoldin_3 PF13758.6 OPL20359.1 - 0.42 10.7 5.9 1.8 8.7 1.3 2.8 1 1 2 3 3 3 0 Prefoldin subunit XhlA PF10779.9 OPL20359.1 - 0.42 10.8 6.6 0.24 11.6 1.8 2.4 1 1 1 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 OPL20359.1 - 0.61 10.1 6.3 0.27 11.3 3.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 OPL20359.1 - 0.97 10.0 11.7 0.28 11.7 8.1 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Tex_N PF09371.10 OPL20359.1 - 1 9.0 8.1 0.1 12.3 2.6 1.8 2 0 0 2 2 2 0 Tex-like protein N-terminal domain Snapin_Pallidin PF14712.6 OPL20359.1 - 1.8 9.1 10.8 0.26 11.7 3.6 2.5 1 1 1 2 2 2 0 Snapin/Pallidin Csm1_N PF18504.1 OPL20359.1 - 1.9 8.9 11.6 1.6 9.1 4.9 2.3 2 0 0 2 2 2 0 Csm1 N-terminal domain Syntaxin_2 PF14523.6 OPL20359.1 - 1.9 8.9 10.9 5.7 7.4 10.9 2.0 1 1 0 1 1 1 0 Syntaxin-like protein DUF5595 PF18077.1 OPL20359.1 - 2.7 8.1 7.8 8.6 6.5 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) TMPIT PF07851.13 OPL20359.1 - 3.2 6.9 5.9 2.7 7.2 5.4 1.3 1 1 0 1 1 1 0 TMPIT-like protein KIP1 PF07765.12 OPL20359.1 - 3.2 7.9 6.8 1.8 8.8 1.5 2.3 1 1 1 2 2 2 0 KIP1-like protein ZapB PF06005.12 OPL20359.1 - 3.5 8.1 13.6 4.3 7.8 1.3 2.6 1 1 0 2 2 2 0 Cell division protein ZapB FlxA PF14282.6 OPL20359.1 - 6.1 6.9 15.6 0.64 10.0 8.8 2.1 2 0 0 2 2 2 0 FlxA-like protein AA_permease PF00324.21 OPL20360.1 - 8e-08 31.3 1.8 9.5e-08 31.0 1.8 1.0 1 0 0 1 1 1 1 Amino acid permease ABC2_membrane_2 PF12679.7 OPL20360.1 - 0.33 10.2 3.3 1.6 7.9 1.8 2.1 1 1 1 2 2 2 0 ABC-2 family transporter protein PMC2NT PF08066.12 OPL20363.1 - 4.4e-07 30.5 0.0 9.6e-07 29.4 0.0 1.5 2 0 0 2 2 2 1 PMC2NT (NUC016) domain Fructosamin_kin PF03881.14 OPL20363.1 - 0.098 11.8 0.0 0.098 11.8 0.0 1.1 1 0 0 1 1 1 0 Fructosamine kinase Vac14_Fab1_bd PF12755.7 OPL20364.1 - 0.00055 20.5 0.0 0.018 15.6 0.0 1.9 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 OPL20364.1 - 0.0014 18.7 0.2 0.051 13.8 0.1 2.3 2 0 0 2 2 2 1 HEAT repeat RNA_pol_Rpb1_5 PF04998.17 OPL20364.1 - 0.0037 16.7 0.0 0.0039 16.7 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 HEAT_2 PF13646.6 OPL20364.1 - 0.041 14.3 0.0 0.95 9.9 0.0 2.0 1 1 1 2 2 2 0 HEAT repeats UBA_6 PF18039.1 OPL20364.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 UBA-like domain GOLD_2 PF13897.6 OPL20365.1 - 0.15 12.6 1.3 0.22 12.0 1.3 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking RED_C PF07807.11 OPL20365.1 - 0.21 12.1 7.6 0.51 10.8 7.6 1.7 1 1 0 1 1 1 0 RED-like protein C-terminal region Glyco_hydro_18 PF00704.28 OPL20367.1 - 0.0057 16.4 0.0 0.007 16.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Bax1-I PF01027.20 OPL20369.1 - 6.6e-16 58.8 13.5 7.3e-16 58.6 13.5 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 PGG PF13962.6 OPL20369.1 - 0.0089 15.8 1.3 0.0089 15.8 1.3 2.1 2 0 0 2 2 2 1 Domain of unknown function DUF3464 PF11947.8 OPL20369.1 - 0.066 13.0 0.7 0.1 12.4 0.7 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_U4 PF03419.13 OPL20369.1 - 0.22 10.7 8.5 0.25 10.6 8.5 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA CPP1-like PF11833.8 OPL20369.1 - 1.6 8.3 7.0 2 8.0 7.0 1.1 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF423 PF04241.15 OPL20369.1 - 3.1 8.1 9.0 1.1 9.5 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF423) Pkinase PF00069.25 OPL20370.1 - 4.9e-05 22.8 0.0 4.9e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL20370.1 - 0.0034 16.7 0.0 0.0035 16.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase IU_nuc_hydro PF01156.19 OPL20371.1 - 2.8e-14 53.4 0.0 3.4e-14 53.1 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF3598 PF12204.8 OPL20372.1 - 0.049 13.1 0.0 0.064 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3598) BNIP2 PF12496.8 OPL20372.1 - 0.071 13.5 0.6 0.11 13.0 0.4 1.4 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 PH PF00169.29 OPL20373.1 - 2.9e-11 43.8 0.3 3.6e-11 43.5 0.3 1.0 1 0 0 1 1 1 1 PH domain zf-C3HC4_3 PF13920.6 OPL20375.1 - 3.1e-14 52.6 6.9 4.3e-14 52.1 6.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL20375.1 - 5.6e-06 26.1 7.5 9.5e-06 25.4 7.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 OPL20375.1 - 3.4e-05 23.6 5.9 0.00012 21.9 4.7 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 OPL20375.1 - 0.00022 21.1 7.3 0.00036 20.4 7.0 1.5 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 OPL20375.1 - 0.00039 20.7 9.4 0.00065 20.0 9.4 1.4 1 0 0 1 1 1 1 Ring finger domain TSC22 PF01166.18 OPL20375.1 - 0.2 12.0 4.0 2.2 8.6 0.4 2.2 2 0 0 2 2 2 0 TSC-22/dip/bun family RecR PF02132.15 OPL20375.1 - 0.23 11.0 9.2 0.28 10.8 0.3 2.8 2 1 1 3 3 3 0 RecR protein zf-C3HC4_2 PF13923.6 OPL20375.1 - 0.25 11.2 10.6 0.75 9.7 9.1 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 OPL20375.1 - 0.34 10.7 5.3 0.21 11.4 1.1 2.6 2 1 0 2 2 2 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 OPL20375.1 - 3.3 7.9 9.1 11 6.3 3.1 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 OPL20375.1 - 3.8 7.6 11.8 0.7 10.0 4.2 2.5 2 0 0 2 2 2 0 RING-type zinc-finger TIR_2 PF13676.6 OPL20376.1 - 1.8e-22 80.1 0.1 3.3e-22 79.3 0.1 1.4 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 OPL20376.1 - 0.0022 17.9 1.1 0.0034 17.2 0.0 1.7 2 0 0 2 2 2 1 TIR domain DUF1863 PF08937.11 OPL20376.1 - 0.028 14.7 0.4 0.26 11.6 0.1 2.4 2 1 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) SAM_3 PF18016.1 OPL20376.1 - 0.097 12.5 0.5 0.097 12.5 0.5 1.7 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Nuc_deoxyri_tr3 PF11071.8 OPL20376.1 - 0.12 12.4 0.3 0.31 11.1 0.0 1.7 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase YtoQ 3H PF02829.14 OPL20376.1 - 0.15 12.4 0.4 25 5.3 0.0 3.0 3 0 0 3 3 3 0 3H domain PMSI1 PF15322.6 OPL20377.1 - 0.0034 16.9 0.3 0.0036 16.8 0.3 1.0 1 0 0 1 1 1 1 Protein missing in infertile sperm 1, putative Toxin_11 PF07473.11 OPL20377.1 - 0.17 12.0 7.5 0.26 11.4 7.5 1.3 1 0 0 1 1 1 0 Spasmodic peptide gm9a; conotoxin from Conus species TIR_2 PF13676.6 OPL20379.1 - 1.7e-15 57.7 0.0 2.2e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 OPL20379.1 - 0.00045 20.1 0.2 0.0015 18.4 0.2 1.8 1 1 0 1 1 1 1 TIR domain DUF1863 PF08937.11 OPL20379.1 - 0.00074 19.8 0.0 0.0012 19.2 0.0 1.3 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) PAD PF03068.15 OPL20379.1 - 0.08 11.9 0.0 0.18 10.8 0.0 1.4 1 1 0 1 1 1 0 Protein-arginine deiminase (PAD) MFS_1 PF07690.16 OPL20380.1 - 0.0088 15.0 0.2 0.01 14.8 0.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MIEAP PF16026.5 OPL20381.1 - 1.8e-14 54.5 0.3 1.9e-14 54.4 0.3 1.1 1 0 0 1 1 1 1 Mitochondria-eating protein PLAT PF01477.23 OPL20382.1 - 5.4e-23 81.8 3.3 6e-11 42.9 0.4 2.1 2 0 0 2 2 2 2 PLAT/LH2 domain Peptidase_M14 PF00246.24 OPL20383.1 - 2.9e-05 24.0 0.0 3.1e-05 23.9 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase adh_short PF00106.25 OPL20384.1 - 7.7e-10 38.5 0.3 8.7e-10 38.4 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL20384.1 - 0.0019 17.8 0.3 0.0021 17.6 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 2-Hacid_dh_C PF02826.19 OPL20384.1 - 0.0063 15.9 0.1 0.0063 15.9 0.1 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 OPL20384.1 - 0.0073 15.6 0.0 0.0077 15.6 0.0 1.1 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain KR PF08659.10 OPL20384.1 - 0.013 15.4 0.1 0.018 15.0 0.1 1.2 1 0 0 1 1 1 0 KR domain CNDH2_M PF16869.5 OPL20385.1 - 9e-16 58.8 1.9 9e-16 58.8 1.9 1.9 2 0 0 2 2 2 1 PF16858 DEAD PF00270.29 OPL20386.1 - 0.0054 16.5 0.3 0.0087 15.8 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 OPL20386.1 - 0.1 12.6 0.2 0.16 12.0 0.2 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit LptF_LptG PF03739.14 OPL20389.1 - 4.3 6.1 3.9 7.9 5.2 3.9 1.4 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG PhaP_Bmeg PF09602.10 OPL20389.1 - 4.7 7.1 17.0 0.19 11.6 9.0 2.6 2 2 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF442 PF04273.13 OPL20390.1 - 2.7e-11 43.5 0.0 0.021 14.9 0.0 3.2 3 0 0 3 3 3 3 Putative phosphatase (DUF442) Y_phosphatase3 PF13350.6 OPL20390.1 - 0.00028 20.9 0.0 0.00049 20.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 OPL20390.1 - 0.1 12.4 0.1 16 5.3 0.0 2.4 1 1 0 2 2 2 0 Dual specificity phosphatase, catalytic domain NAD_binding_4 PF07993.12 OPL20391.1 - 3.5e-25 88.6 0.0 4.7e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 OPL20391.1 - 9.5e-09 35.1 0.0 1.3e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 OPL20391.1 - 2.8e-07 29.8 0.0 2.2e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 OPL20391.1 - 0.00059 19.0 0.0 0.00078 18.6 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Fasciclin PF02469.22 OPL20392.1 - 1.4e-19 70.6 0.0 1.8e-19 70.2 0.0 1.0 1 0 0 1 1 1 1 Fasciclin domain AF-4 PF05110.13 OPL20393.1 - 0.1 10.7 49.4 0.12 10.4 49.4 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Herpes_capsid PF06112.11 OPL20393.1 - 0.42 10.7 21.9 0.86 9.7 21.9 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein HYR PF02494.16 OPL20394.1 - 3.3e-10 40.2 0.8 5.7e-10 39.4 0.8 1.4 1 0 0 1 1 1 1 HYR domain Sushi PF00084.20 OPL20394.1 - 4.2e-08 33.7 23.9 8.6e-06 26.3 2.9 3.8 4 0 0 4 4 4 3 Sushi repeat (SCR repeat) DUF5011 PF16403.5 OPL20394.1 - 0.024 14.8 0.2 0.051 13.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5011) VPS9 PF02204.18 OPL20395.1 - 0.003 17.7 0.0 0.0054 16.9 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain ASH PF15780.5 OPL20396.1 - 5.7e-05 23.3 1.2 0.00063 19.9 0.1 2.1 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin MYCBPAP PF14646.6 OPL20396.1 - 0.035 13.0 0.5 1.9 7.3 0.1 2.3 1 1 1 2 2 2 0 MYCBP-associated protein family ABC_tran PF00005.27 OPL20398.1 - 1.4e-19 70.9 0.0 2.7e-19 70.0 0.0 1.5 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 OPL20398.1 - 1.5e-05 24.5 0.3 0.03 13.8 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 OPL20398.1 - 0.045 13.6 0.0 6.4 6.5 0.0 2.2 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 OPL20398.1 - 0.05 13.5 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 OPL20398.1 - 0.072 13.6 0.1 0.2 12.1 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 OPL20398.1 - 0.082 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4922 PF16269.5 OPL20399.1 - 0.023 14.5 0.1 0.035 13.9 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4922) AP3D1 PF06375.11 OPL20400.1 - 0.023 14.9 1.1 0.033 14.4 1.1 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 BTB PF00651.31 OPL20401.1 - 3.9e-20 72.1 0.0 5.1e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 OPL20401.1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.5 1 1 0 1 1 1 0 BTB/POZ domain Ribosomal_S28e PF01200.18 OPL20403.1 - 5.8e-32 109.5 0.8 6e-32 109.4 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e DNA_pol_phi PF04931.13 OPL20406.1 - 3.5e-30 104.8 24.1 3.9e-30 104.6 24.1 1.0 1 0 0 1 1 1 1 DNA polymerase phi CBF PF03914.17 OPL20406.1 - 0.028 14.5 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 CBF/Mak21 family BUD22 PF09073.10 OPL20406.1 - 0.13 11.6 18.9 0.14 11.4 18.9 1.2 1 0 0 1 1 1 0 BUD22 SAPS PF04499.15 OPL20406.1 - 0.17 10.6 6.6 0.18 10.6 6.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF913 PF06025.12 OPL20406.1 - 0.33 9.9 3.6 0.42 9.5 3.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CobT PF06213.12 OPL20406.1 - 0.38 10.1 18.0 0.42 10.0 18.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 OPL20406.1 - 0.42 8.8 14.3 0.45 8.8 14.3 1.2 1 0 0 1 1 1 0 CDC45-like protein COPI_C PF06957.11 OPL20406.1 - 0.77 8.4 8.0 0.95 8.1 8.0 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus Presenilin PF01080.17 OPL20406.1 - 0.87 8.3 2.3 0.94 8.2 2.3 1.2 1 0 0 1 1 1 0 Presenilin SURF2 PF05477.11 OPL20406.1 - 1.3 8.7 7.8 1.8 8.2 7.8 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF2151 PF10221.9 OPL20406.1 - 1.5 7.3 6.7 1.6 7.2 6.7 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator CDC27 PF09507.10 OPL20406.1 - 1.8 7.9 15.1 1.8 7.9 15.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TRAP_alpha PF03896.16 OPL20406.1 - 6.9 5.8 14.7 11 5.1 14.7 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SDA1 PF05285.12 OPL20406.1 - 7.3 5.9 26.5 9.6 5.5 26.5 1.2 1 0 0 1 1 1 0 SDA1 Cpn60_TCP1 PF00118.24 OPL20407.1 - 1.7e-09 36.9 0.1 3.1e-09 36.0 0.1 1.4 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family YusW PF14039.6 OPL20407.1 - 0.17 12.4 1.0 8.2 7.0 0.1 2.9 3 0 0 3 3 3 0 YusW-like protein Phospholip_A2_2 PF05826.12 OPL20407.1 - 3.5 7.9 9.4 0.92 9.8 0.1 2.9 3 0 0 3 3 3 0 Phospholipase A2 HlyU PF10115.9 OPL20408.1 - 0.056 13.5 0.1 0.069 13.2 0.1 1.1 1 0 0 1 1 1 0 Transcriptional activator HlyU RRM_1 PF00076.22 OPL20408.1 - 0.09 12.6 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S17 PF00366.20 OPL20408.1 - 0.11 12.6 0.1 0.14 12.3 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein S17 C2 PF00168.30 OPL20409.1 - 3.9e-08 33.5 0.0 6.2e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain PH PF00169.29 OPL20409.1 - 0.00045 20.7 0.1 0.002 18.6 0.0 1.9 2 1 0 2 2 2 1 PH domain zf-H2C2_2 PF13465.6 OPL20410.1 - 1.1e-47 158.4 61.4 7e-08 32.6 0.3 10.2 10 1 0 10 10 10 7 Zinc-finger double domain zf-C2H2 PF00096.26 OPL20410.1 - 2.3e-35 119.1 76.8 1e-06 28.8 0.4 10.3 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 OPL20410.1 - 2.6e-28 96.3 67.2 0.00017 22.1 0.3 10.0 9 1 1 10 10 10 9 C2H2-type zinc finger zf-met PF12874.7 OPL20410.1 - 1.4e-14 53.9 43.3 0.00068 19.9 0.4 9.7 8 1 1 9 9 9 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 OPL20410.1 - 1.7e-13 50.1 55.1 0.018 15.0 0.5 9.7 9 1 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 OPL20410.1 - 2.7e-12 46.6 47.9 0.00026 21.2 0.6 9.1 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding BolA PF01722.18 OPL20410.1 - 0.0026 18.0 6.6 0.2 12.0 0.6 4.0 2 2 1 3 3 3 1 BolA-like protein zf-C2H2_11 PF16622.5 OPL20410.1 - 0.43 10.4 0.0 0.43 10.4 0.0 5.5 6 0 0 6 6 6 0 zinc-finger C2H2-type GAGA PF09237.11 OPL20410.1 - 7 6.5 11.9 3.1 7.7 0.2 4.6 2 2 2 5 5 5 0 GAGA factor DUF4342 PF14242.6 OPL20412.1 - 0.16 12.0 1.0 0.28 11.2 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) UPF0239 PF06783.11 OPL20412.1 - 0.17 12.1 2.7 0.23 11.7 0.1 2.5 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0239) EphA2_TM PF14575.6 OPL20412.1 - 0.19 12.6 1.8 0.21 12.5 0.1 1.9 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain VARLMGL PF14383.6 OPL20413.1 - 0.012 15.1 0.2 0.03 13.8 0.2 1.6 1 0 0 1 1 1 0 DUF761-associated sequence motif DUF3332 PF11810.8 OPL20413.1 - 0.078 12.6 0.6 0.1 12.2 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) INPP5B_PH PF16776.5 OPL20414.1 - 2.5e-09 37.0 0.1 3e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain Acyl_transf_1 PF00698.21 OPL20416.1 - 1.1e-69 235.4 0.0 1.3e-69 235.1 0.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 OPL20416.1 - 2.8e-15 56.3 0.0 4.2e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Guanylate_cyc PF00211.20 OPL20417.1 - 4e-23 82.0 0.1 4.3e-23 81.9 0.1 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain TRAPPC9-Trs120 PF08626.11 OPL20418.1 - 3.3e-08 31.4 0.1 1e-07 29.8 0.1 1.6 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Adaptin_binding PF10199.9 OPL20419.1 - 3.9e-10 40.4 0.8 6e-10 39.8 0.8 1.4 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 SLD5_C PF16922.5 OPL20420.1 - 1.2e-17 63.8 0.1 1.4e-17 63.6 0.1 1.1 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Arf PF00025.21 OPL20421.1 - 3.2e-64 215.6 0.0 3.7e-64 215.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 OPL20421.1 - 2.4e-15 56.8 0.0 3.3e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL20421.1 - 3.4e-14 52.8 0.0 3.9e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 OPL20421.1 - 3e-11 43.1 0.0 3e-07 29.9 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 OPL20421.1 - 3e-11 43.1 0.0 4e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 OPL20421.1 - 7.5e-09 35.3 0.0 9.9e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 OPL20421.1 - 0.00014 21.9 0.1 0.0002 21.4 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DLIC PF05783.11 OPL20421.1 - 0.027 13.3 0.1 0.95 8.2 0.0 2.0 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) 6PF2K PF01591.18 OPL20421.1 - 0.074 12.3 0.0 0.11 11.8 0.0 1.5 1 1 0 1 1 1 0 6-phosphofructo-2-kinase LPMO_10 PF03067.15 OPL20422.1 - 2.1e-28 100.3 0.2 2.1e-28 100.3 0.2 1.6 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Mucin PF01456.17 OPL20422.1 - 6.5e-07 29.4 20.8 1e-06 28.8 20.8 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein SOG2 PF10428.9 OPL20422.1 - 0.0086 15.3 3.7 0.01 15.1 3.7 1.0 1 0 0 1 1 1 1 RAM signalling pathway protein CDC27 PF09507.10 OPL20422.1 - 0.7 9.2 7.7 0.92 8.8 7.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 F5_F8_type_C PF00754.25 OPL20423.1 - 0.00039 20.6 0.0 0.00049 20.2 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain WD40 PF00400.32 OPL20426.1 - 3e-07 31.0 0.1 0.00013 22.7 0.0 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat WD40 PF00400.32 OPL20427.1 - 1.5e-06 28.8 5.0 0.0041 17.9 0.0 4.2 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 OPL20427.1 - 1.9e-05 24.9 0.2 0.00084 19.6 0.2 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 OPL20427.1 - 0.00031 19.6 0.1 0.0006 18.7 0.0 1.5 2 0 0 2 2 2 1 Nup133 N terminal like Hira PF07569.11 OPL20427.1 - 0.00063 19.5 0.0 0.018 14.8 0.0 2.2 2 0 0 2 2 2 1 TUP1-like enhancer of split S1 PF00575.23 OPL20428.1 - 0.03 14.7 0.4 0.054 13.8 0.4 1.4 1 0 0 1 1 1 0 S1 RNA binding domain Actin PF00022.19 OPL20429.1 - 3.9e-76 256.3 0.0 4.7e-76 256.0 0.0 1.0 1 0 0 1 1 1 1 Actin GerD PF17898.1 OPL20429.1 - 0.027 14.4 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Spore germination GerD central core domain Sushi PF00084.20 OPL20431.1 - 1.1e-18 67.6 8.9 5.6e-09 36.5 1.7 2.1 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) Astro_capsid_p2 PF16580.5 OPL20431.1 - 0.012 15.1 2.8 0.36 10.2 0.1 2.1 1 1 0 2 2 2 0 C-terminal tail of astrovirus capsid projection or spike Arm-DNA-bind_4 PF14657.6 OPL20431.1 - 0.11 12.2 0.2 1.8 8.4 0.1 2.2 2 0 0 2 2 2 0 Arm DNA-binding domain DUF5113 PF17140.4 OPL20431.1 - 0.16 11.8 0.0 7.5 6.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) HRM PF02793.22 OPL20431.1 - 1.9 8.8 6.4 21 5.5 2.1 2.6 1 1 1 2 2 2 0 Hormone receptor domain HPS3_Mid PF14762.6 OPL20433.1 - 5e-30 104.5 0.3 2.4e-29 102.3 0.3 1.8 1 1 0 1 1 1 1 Hermansky-Pudlak syndrome 3, middle region Drf_FH1 PF06346.12 OPL20434.1 - 0.031 14.0 11.2 0.47 10.2 11.4 2.7 1 1 0 1 1 1 0 Formin Homology Region 1 VOMI PF03762.17 OPL20435.1 - 3.6e-38 131.4 0.8 3.8e-38 131.3 0.8 1.0 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) Toprim_C_rpt PF13368.6 OPL20435.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat Hormone_4 PF00220.17 OPL20435.1 - 1.1 9.4 4.9 4 7.6 0.5 2.5 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain UCH PF00443.29 OPL20437.1 - 3.8e-23 82.3 0.3 5.2e-23 81.8 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 OPL20437.1 - 1.4e-13 51.2 0.0 2.1e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase FH2 PF02181.23 OPL20441.1 - 4.4e-26 91.9 5.1 4.9e-26 91.7 3.9 1.6 1 1 1 2 2 2 2 Formin Homology 2 Domain MtrG PF04210.13 OPL20441.1 - 0.042 13.7 0.4 8.6 6.3 0.0 3.1 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G RtcB PF01139.17 OPL20441.1 - 0.09 11.9 0.3 0.15 11.3 0.2 1.4 1 1 0 1 1 1 0 tRNA-splicing ligase RtcB RVT_1 PF00078.27 OPL20442.1 - 0.00012 21.6 0.1 0.00014 21.4 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sugar_tr PF00083.24 OPL20443.1 - 0.00012 21.1 0.1 0.00015 20.8 0.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter RIC1 PF07064.13 OPL20443.1 - 0.03 13.7 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 RIC1 Peptidase_C39_2 PF13529.6 OPL20443.1 - 0.1 13.1 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 Peptidase_C39 like family fn3 PF00041.21 OPL20444.1 - 9.6e-14 51.5 0.0 2.1e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain zf-CCCH_3 PF15663.5 OPL20444.1 - 8.6e-07 29.2 0.1 2.3e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 Zinc-finger containing family AAA_29 PF13555.6 OPL20444.1 - 0.00068 19.3 0.1 0.0013 18.4 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 OPL20444.1 - 0.042 13.3 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 OPL20444.1 - 0.046 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase FtsK_SpoIIIE PF01580.18 OPL20444.1 - 0.055 12.8 0.2 0.086 12.2 0.2 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.27 OPL20444.1 - 0.077 13.5 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DUF815 PF05673.13 OPL20444.1 - 0.19 10.9 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Arm PF00514.23 OPL20446.1 - 1.5e-07 31.2 1.2 3.6e-06 26.8 0.0 2.8 3 1 0 3 3 3 1 Armadillo/beta-catenin-like repeat APC_rep PF18797.1 OPL20446.1 - 0.00099 20.0 0.2 0.55 11.2 0.0 2.4 1 1 1 2 2 2 2 Adenomatous polyposis coli (APC) repeat V-ATPase_H_N PF03224.14 OPL20446.1 - 0.0017 17.7 0.0 0.0021 17.4 0.0 1.1 1 0 0 1 1 1 1 V-ATPase subunit H HEPN_DZIP3 PF18738.1 OPL20447.1 - 3.4e-31 107.9 0.1 4e-31 107.7 0.1 1.1 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN Helicase_C PF00271.31 OPL20449.1 - 0.00015 22.1 0.0 0.00028 21.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Sacchrp_dh_C PF16653.5 OPL20449.1 - 0.13 12.4 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain PTPLA PF04387.14 OPL20450.1 - 2.9e-13 49.9 0.3 3.8e-13 49.5 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA RNase_P_Rpp14 PF01900.19 OPL20451.1 - 6.3e-07 29.6 1.1 2.7e-06 27.5 0.1 1.9 2 0 0 2 2 2 1 Rpp14/Pop5 family Phospholip_A2_2 PF05826.12 OPL20453.1 - 2.1 8.6 5.2 0.98 9.7 2.2 2.1 2 0 0 2 2 2 0 Phospholipase A2 A_deamin PF02137.18 OPL20454.1 - 1.7e-49 169.0 0.0 2e-49 168.8 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain BDHCT PF08072.11 OPL20454.1 - 0.072 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 BDHCT (NUC031) domain DUF4200 PF13863.6 OPL20455.1 - 0.00035 20.9 19.8 0.001 19.5 19.8 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4200) DUF4472 PF14739.6 OPL20455.1 - 0.0037 18.0 18.0 0.14 12.9 8.1 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4472) Myosin_tail_1 PF01576.19 OPL20455.1 - 0.0037 15.2 18.9 0.0046 14.8 18.9 1.1 1 0 0 1 1 1 1 Myosin tail DUF3450 PF11932.8 OPL20455.1 - 0.004 16.5 13.1 0.0071 15.7 11.9 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 OPL20455.1 - 0.0047 17.1 19.2 0.085 13.1 10.0 3.1 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding APG6_N PF17675.1 OPL20455.1 - 0.0065 17.0 20.5 0.02 15.4 13.7 2.4 1 1 1 2 2 2 2 Apg6 coiled-coil region IL5 PF02025.15 OPL20455.1 - 0.01 16.1 2.7 0.01 16.1 2.7 1.9 1 1 1 2 2 2 0 Interleukin 5 NBP1 PF08537.10 OPL20455.1 - 0.018 14.5 16.1 0.02 14.3 16.1 1.0 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 TPR_MLP1_2 PF07926.12 OPL20455.1 - 0.019 15.0 18.1 0.051 13.6 7.5 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 OPL20455.1 - 0.027 13.9 6.8 0.034 13.5 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 OPL20455.1 - 0.032 14.7 16.1 0.041 14.3 16.1 1.2 1 0 0 1 1 1 0 Fez1 Exonuc_VII_L PF02601.15 OPL20455.1 - 0.041 13.5 9.9 0.046 13.3 9.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-F_leu_zip PF10473.9 OPL20455.1 - 0.046 13.7 22.9 6.8 6.7 8.2 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 STAT_alpha PF01017.20 OPL20455.1 - 0.05 13.5 16.7 0.1 12.5 9.5 2.1 1 1 1 2 2 2 0 STAT protein, all-alpha domain DUF1664 PF07889.12 OPL20455.1 - 0.052 13.6 14.5 0.04 14.0 6.6 2.3 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) IFT57 PF10498.9 OPL20455.1 - 0.062 12.3 18.1 0.08 11.9 16.6 1.7 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Pox_F16 PF04708.12 OPL20455.1 - 0.1 12.1 7.9 0.013 15.0 3.5 1.7 2 0 0 2 2 2 0 Poxvirus F16 protein RL10P_insert PF17777.1 OPL20455.1 - 0.15 12.0 0.7 0.54 10.3 0.7 2.2 1 1 0 1 1 1 0 Insertion domain in 60S ribosomal protein L10P BRE1 PF08647.11 OPL20455.1 - 0.19 11.8 19.6 0.25 11.4 13.1 2.8 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase Nsp1_C PF05064.13 OPL20455.1 - 0.25 11.2 13.9 0.92 9.3 0.5 3.2 2 1 1 3 3 3 0 Nsp1-like C-terminal region DUF4164 PF13747.6 OPL20455.1 - 0.26 11.6 11.4 0.12 12.7 5.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Laminin_II PF06009.12 OPL20455.1 - 0.31 11.1 12.8 1.2 9.2 6.7 2.2 1 1 1 2 2 2 0 Laminin Domain II Het-C PF07217.11 OPL20455.1 - 0.4 9.1 8.3 0.48 8.9 8.3 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C MCPsignal PF00015.21 OPL20455.1 - 0.49 10.2 7.6 0.77 9.6 4.8 2.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Fib_alpha PF08702.10 OPL20455.1 - 0.5 10.6 17.7 10 6.3 17.7 2.2 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 OPL20455.1 - 0.74 8.6 20.3 1.6 7.6 8.8 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein ADIP PF11559.8 OPL20455.1 - 0.79 9.8 20.6 0.062 13.4 10.1 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 OPL20455.1 - 0.85 9.8 17.1 3.3 7.9 17.1 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) PIN_8 PF18476.1 OPL20455.1 - 1.1 9.1 13.5 2 8.2 13.3 1.5 1 1 0 1 1 1 0 PIN like domain FOXP-CC PF16159.5 OPL20455.1 - 1.3 9.7 11.0 0.18 12.4 1.2 2.7 2 2 0 2 2 2 0 FOXP coiled-coil domain LXG PF04740.12 OPL20455.1 - 1.3 8.7 16.0 0.79 9.4 6.5 2.2 1 1 1 2 2 2 0 LXG domain of WXG superfamily RmuC PF02646.16 OPL20455.1 - 1.5 7.9 15.4 0.59 9.2 6.9 2.1 1 1 1 2 2 2 0 RmuC family V_ATPase_I PF01496.19 OPL20455.1 - 2 6.2 14.4 2.7 5.8 14.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cep57_CLD_2 PF14197.6 OPL20455.1 - 2.5 8.2 13.6 9.5 6.4 0.9 2.6 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 CLZ PF16526.5 OPL20455.1 - 2.6 8.4 12.2 0.26 11.7 3.5 2.9 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3573 PF12097.8 OPL20455.1 - 3.1 6.5 5.1 3.7 6.3 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) OmpH PF03938.14 OPL20455.1 - 4 7.8 13.7 9.7 6.5 13.7 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3251 PF11622.8 OPL20455.1 - 4.2 7.0 10.0 4.6 6.8 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3251) AATF-Che1 PF13339.6 OPL20455.1 - 4.8 7.9 14.2 1.5e+02 3.0 14.1 2.2 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor SWIRM-assoc_1 PF16495.5 OPL20455.1 - 5.2 7.1 12.3 1.6 8.8 0.5 2.9 2 1 0 2 2 2 0 SWIRM-associated region 1 LMBR1 PF04791.16 OPL20455.1 - 6.6 5.5 9.9 6.8 5.5 9.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Prominin PF05478.11 OPL20455.1 - 7.7 4.3 12.8 12 3.7 12.8 1.4 1 1 0 1 1 1 0 Prominin Tho2 PF11262.8 OPL20455.1 - 7.8 5.6 19.4 3 7.0 5.0 2.1 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Lectin_N PF03954.14 OPL20455.1 - 7.8 6.2 10.7 1 9.1 3.1 2.1 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF4160 PF13711.6 OPL20456.1 - 0.062 13.6 1.7 8.4 6.8 0.7 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4160) RNase_HII PF01351.18 OPL20456.1 - 0.17 11.7 1.7 0.46 10.3 0.1 2.4 2 1 1 3 3 3 0 Ribonuclease HII WD40 PF00400.32 OPL20457.1 - 1e-10 42.0 2.9 3.4e-05 24.5 0.2 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 OPL20457.1 - 3.3e-06 27.3 0.1 0.077 13.3 0.0 2.5 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 OPL20457.1 - 0.051 12.5 0.1 0.12 11.3 0.1 1.5 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF3254 PF11630.8 OPL20457.1 - 0.054 13.7 0.0 0.088 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3254) GAGA_bind PF06217.12 OPL20458.1 - 9.3 6.4 12.2 16 5.6 11.8 1.6 1 1 0 1 1 1 0 GAGA binding protein-like family Cas1_AcylT PF07779.12 OPL20459.1 - 1.4e-39 136.3 9.2 3.3e-27 95.6 0.9 3.0 1 1 2 3 3 3 3 10 TM Acyl Transferase domain found in Cas1p DUF218 PF02698.17 OPL20460.1 - 4.7e-21 75.2 0.0 6.8e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 DUF218 domain DUF1866 PF08952.11 OPL20460.1 - 0.11 12.3 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) Defensin_beta PF00711.19 OPL20461.1 - 0.11 12.5 6.8 1.5 8.9 0.3 2.5 3 0 0 3 3 3 0 Beta defensin Sulfatase PF00884.23 OPL20462.1 - 7.6e-07 28.8 0.0 1.3e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 OPL20462.1 - 6.7e-06 26.3 1.9 0.013 15.8 0.9 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4976) HSP70 PF00012.20 OPL20463.1 - 3.5e-155 517.6 14.0 2.1e-152 508.4 3.8 2.7 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 OPL20463.1 - 3.2e-09 36.1 0.0 1.1e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein StbA PF06406.11 OPL20463.1 - 0.0076 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 StbA protein Hydantoinase_A PF01968.18 OPL20463.1 - 0.13 11.5 0.1 0.28 10.4 0.1 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Focadhesin PF11229.8 OPL20464.1 - 6.5e-20 70.9 0.1 1.7e-19 69.5 0.1 1.6 1 1 0 1 1 1 1 Focadhesin DALR_1 PF05746.15 OPL20465.1 - 0.11 12.7 0.1 18 5.5 0.0 2.6 2 0 0 2 2 2 0 DALR anticodon binding domain TMEM187 PF15100.6 OPL20466.1 - 2.6e-30 105.8 0.5 3.1e-30 105.5 0.5 1.1 1 0 0 1 1 1 1 TMEM187 protein family EGF PF00008.27 OPL20467.1 - 3.2e-14 52.9 46.6 2.7e-07 30.8 7.9 4.5 4 1 0 4 4 4 3 EGF-like domain EGF_2 PF07974.13 OPL20467.1 - 1.4e-05 25.3 52.1 0.0063 16.9 13.4 4.4 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 OPL20467.1 - 3.4e-05 24.3 4.2 3.4e-05 24.3 4.2 6.0 7 0 0 7 7 7 2 Human growth factor-like EGF cEGF PF12662.7 OPL20467.1 - 6.1e-05 22.9 11.7 0.0035 17.2 0.6 4.8 6 0 0 6 6 6 2 Complement Clr-like EGF-like EGF_3 PF12947.7 OPL20467.1 - 0.00028 21.0 7.4 0.00028 21.0 7.4 4.4 4 1 0 4 4 4 2 EGF domain EGF_CA PF07645.15 OPL20467.1 - 0.0013 18.9 12.5 0.0013 18.9 12.5 4.1 2 2 2 4 4 4 2 Calcium-binding EGF domain FXa_inhibition PF14670.6 OPL20467.1 - 0.0014 18.9 8.3 0.0014 18.9 8.3 4.4 2 2 2 4 4 4 1 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 OPL20467.1 - 0.49 10.7 30.4 0.64 10.4 5.4 3.8 2 2 1 3 3 3 0 Pvs28 EGF domain Laminin_EGF PF00053.24 OPL20467.1 - 5.5 7.2 42.2 1.5 9.0 12.3 4.2 1 1 3 4 4 4 0 Laminin EGF domain Spore_III_AF PF09581.10 OPL20468.1 - 0.038 14.0 0.3 0.055 13.5 0.3 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Ion_trans PF00520.31 OPL20469.1 - 3.9e-05 23.0 0.1 5e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Ion transport protein Cadherin PF00028.17 OPL20470.1 - 2e-06 28.1 0.5 0.015 15.7 0.0 2.4 1 1 1 2 2 2 2 Cadherin domain DIM1 PF02966.16 OPL20471.1 - 1.2e-31 109.2 0.1 1.4e-31 109.1 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 OPL20471.1 - 0.00018 21.4 0.0 0.00024 21.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin zf-C2H2 PF00096.26 OPL20472.1 - 3.4e-06 27.2 3.3 4.5e-05 23.7 0.3 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 OPL20472.1 - 8.1e-05 23.1 3.4 0.0054 17.5 0.2 3.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 OPL20472.1 - 0.00014 22.2 0.1 0.00014 22.2 0.1 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 OPL20472.1 - 0.003 17.8 0.1 0.003 17.8 0.1 3.5 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 OPL20472.1 - 0.0035 17.1 4.5 0.031 14.0 0.1 3.1 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-BED PF02892.15 OPL20472.1 - 1.5 8.9 6.1 6.8 6.8 0.7 3.1 3 0 0 3 3 3 0 BED zinc finger zf-H2C2_2 PF13465.6 OPL20472.1 - 2.3 8.8 6.8 1.1 9.8 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger double domain IF-2 PF11987.8 OPL20473.1 - 8.8e-27 93.3 0.1 2.2e-26 92.0 0.1 1.6 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 OPL20473.1 - 0.0074 16.2 0.2 0.021 14.7 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 OPL20473.1 - 0.025 15.0 0.8 0.091 13.2 0.2 2.2 3 0 0 3 3 3 0 Elongation factor Tu domain 2 DDE_Tnp_4 PF13359.6 OPL20476.1 - 6.3e-34 116.9 0.1 8.9e-34 116.5 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 OPL20476.1 - 3.1e-07 30.2 0.2 2.1e-06 27.5 0.2 2.0 1 1 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 OPL20476.1 - 3.1e-07 30.3 1.2 4.6e-05 23.2 1.2 2.3 1 1 0 1 1 1 1 Transposase DDE domain HTH_Tnp_4 PF13613.6 OPL20476.1 - 1.8e-05 24.4 0.0 5.3e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_1_2 PF13586.6 OPL20476.1 - 0.015 15.7 0.0 0.043 14.2 0.0 1.8 2 0 0 2 2 2 0 Transposase DDE domain HTH_38 PF13936.6 OPL20476.1 - 0.13 12.0 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Steroid_dh PF02544.16 OPL20480.1 - 4e-46 156.7 0.2 4.3e-46 156.6 0.2 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 OPL20480.1 - 5.6e-07 29.3 0.1 6.5e-07 29.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Pkinase PF00069.25 OPL20481.1 - 3.8e-25 88.8 0.2 4.1e-25 88.6 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL20481.1 - 1.8e-11 43.8 0.1 2e-11 43.7 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase CTU2 PF10288.9 OPL20482.1 - 0.0016 18.7 1.5 0.0023 18.1 1.5 1.2 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 MHCassoc_trimer PF08831.10 OPL20484.1 - 0.11 12.5 0.2 0.32 11.1 0.2 1.7 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain TNFR_c6 PF00020.18 OPL20485.1 - 3.6e-16 59.3 30.1 3.4e-06 27.3 0.5 4.3 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 OPL20485.1 - 0.0012 18.6 32.5 0.023 14.5 2.2 4.3 2 2 2 4 4 4 3 Putative ephrin-receptor like Asparaginase_2 PF01112.18 OPL20486.1 - 2.9e-22 79.1 0.0 3.6e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Asparaginase p450 PF00067.22 OPL20488.1 - 4e-80 269.8 0.0 5e-80 269.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tma16 PF11176.8 OPL20488.1 - 0.026 14.4 0.4 0.044 13.7 0.4 1.4 1 0 0 1 1 1 0 Translation machinery-associated protein 16 VWA_3 PF13768.6 OPL20489.1 - 7.5e-08 32.5 0.0 9.8e-08 32.1 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 OPL20489.1 - 3.2e-06 27.5 0.0 3.4e-06 27.4 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL20489.1 - 0.0017 19.0 0.0 0.014 16.0 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain FPP PF05911.11 OPL20491.1 - 1.2e-05 23.8 8.3 1.4e-05 23.5 8.3 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ATG16 PF08614.11 OPL20491.1 - 0.00012 22.4 8.9 0.00016 22.0 8.9 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.19 OPL20491.1 - 0.0027 15.6 9.4 0.0031 15.4 9.4 1.0 1 0 0 1 1 1 1 Myosin tail AAA_13 PF13166.6 OPL20491.1 - 0.0043 15.8 6.8 0.0051 15.5 6.8 1.0 1 0 0 1 1 1 1 AAA domain GAS PF13851.6 OPL20491.1 - 0.0065 15.8 14.3 0.0082 15.5 14.3 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 OPL20491.1 - 0.013 15.6 13.8 0.037 14.0 13.9 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RasGAP_C PF03836.15 OPL20491.1 - 0.015 15.4 9.2 0.022 14.9 9.2 1.2 1 0 0 1 1 1 0 RasGAP C-terminus SWIRM-assoc_1 PF16495.5 OPL20491.1 - 0.021 14.7 5.2 0.021 14.7 5.2 2.1 1 1 1 2 2 2 0 SWIRM-associated region 1 DHR10 PF18595.1 OPL20491.1 - 0.022 14.8 10.4 0.022 14.8 10.4 1.9 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain APG6_N PF17675.1 OPL20491.1 - 0.023 15.2 15.3 0.045 14.3 15.3 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region COG2 PF06148.11 OPL20491.1 - 0.029 14.4 5.0 0.039 14.1 4.6 1.3 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Filament PF00038.21 OPL20491.1 - 0.03 13.9 11.4 0.024 14.2 8.8 1.8 1 1 1 2 2 2 0 Intermediate filament protein LMBR1 PF04791.16 OPL20491.1 - 0.031 13.2 1.4 0.032 13.2 1.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Nsp1_C PF05064.13 OPL20491.1 - 0.033 14.0 6.7 0.03 14.1 5.7 1.4 1 1 0 1 1 1 0 Nsp1-like C-terminal region FlxA PF14282.6 OPL20491.1 - 0.055 13.5 18.6 0.1 12.6 18.6 1.4 1 0 0 1 1 1 0 FlxA-like protein Spc7 PF08317.11 OPL20491.1 - 0.057 12.3 10.3 0.07 12.0 10.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 OPL20491.1 - 0.071 13.3 12.7 0.11 12.6 12.7 1.2 1 0 0 1 1 1 0 Tropomyosin like DUF211 PF02680.14 OPL20491.1 - 0.09 12.9 0.4 0.12 12.5 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 DUF2203 PF09969.9 OPL20491.1 - 0.1 13.3 4.4 0.16 12.7 4.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) TolA_bind_tri PF16331.5 OPL20491.1 - 0.12 12.5 7.5 1.9 8.6 3.9 2.4 1 1 1 2 2 2 0 TolA binding protein trimerisation HAUS-augmin3 PF14932.6 OPL20491.1 - 0.12 11.9 11.6 2.1 7.9 2.1 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Prefoldin_2 PF01920.20 OPL20491.1 - 0.14 12.2 16.3 0.098 12.6 7.7 2.1 1 1 1 2 2 2 0 Prefoldin subunit DUF2968 PF11180.8 OPL20491.1 - 0.15 11.7 9.2 0.07 12.8 7.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) FapA PF03961.13 OPL20491.1 - 0.17 10.5 9.1 0.19 10.3 9.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A EHN PF06441.12 OPL20491.1 - 0.19 12.1 2.4 0.41 11.0 0.5 2.0 1 1 1 2 2 2 0 Epoxide hydrolase N terminus Atg14 PF10186.9 OPL20491.1 - 0.22 10.6 11.1 0.28 10.2 11.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3450 PF11932.8 OPL20491.1 - 0.24 10.7 14.3 0.51 9.6 5.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF16 PF01519.16 OPL20491.1 - 0.26 11.8 10.7 0.33 11.5 8.8 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF4201 PF13870.6 OPL20491.1 - 0.3 10.8 14.7 0.4 10.4 14.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) TMPIT PF07851.13 OPL20491.1 - 0.85 8.8 8.9 1.1 8.4 8.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein Cep57_MT_bd PF06657.13 OPL20491.1 - 1.2 9.6 11.3 0.18 12.3 5.4 2.0 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 HIP1_clath_bdg PF16515.5 OPL20491.1 - 1.3 9.6 12.7 2.3 8.9 12.7 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4140 PF13600.6 OPL20491.1 - 1.7 9.2 9.5 83 3.7 9.5 2.6 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF5082 PF16888.5 OPL20491.1 - 2.4 8.5 18.7 3.7 7.8 6.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) TMF_DNA_bd PF12329.8 OPL20491.1 - 2.5 8.2 20.4 1.3 9.0 7.3 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF724 PF05266.14 OPL20491.1 - 2.5 7.9 12.5 4.9 6.9 12.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF641 PF04859.12 OPL20491.1 - 2.7 8.4 11.0 6.5 7.1 10.9 1.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4407 PF14362.6 OPL20491.1 - 2.7 7.3 6.3 4.2 6.6 6.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 OPL20491.1 - 2.9 7.7 15.2 4.3 7.2 2.5 2.5 1 1 1 2 2 2 0 Septum formation initiator JIP_LZII PF16471.5 OPL20491.1 - 3.2 8.0 13.1 2.6 8.3 1.8 2.2 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II FlaC_arch PF05377.11 OPL20491.1 - 3.8 8.0 13.2 0.38 11.2 2.4 2.8 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF4200 PF13863.6 OPL20491.1 - 4.1 7.8 18.6 6.3 7.2 6.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Sec2p PF06428.11 OPL20491.1 - 5.9 6.9 14.7 4 7.5 6.8 2.2 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p DUF1664 PF07889.12 OPL20491.1 - 6.3 6.9 10.5 8.4 6.5 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.12 OPL20491.1 - 7.6 7.2 9.9 6.4 7.5 6.4 2.0 1 1 1 2 2 2 0 SlyX Cryptochrome_C PF12546.8 OPL20492.1 - 0.091 13.4 0.0 0.39 11.3 0.0 2.0 2 1 0 2 2 2 0 Blue/Ultraviolet sensing protein C terminal Patatin PF01734.22 OPL20493.1 - 1.5e-07 31.8 2.9 2.3e-07 31.2 2.9 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase Dynein_light PF01221.18 OPL20494.1 - 2.2e-42 143.2 1.2 4e-42 142.4 1.2 1.4 1 0 0 1 1 1 1 Dynein light chain type 1 Nop PF01798.18 OPL20494.1 - 0.085 12.3 0.0 0.092 12.2 0.0 1.1 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin YqzH PF14164.6 OPL20496.1 - 0.16 12.1 0.1 0.96 9.6 0.0 2.2 2 0 0 2 2 2 0 YqzH-like protein zf-MYND PF01753.18 OPL20497.1 - 2e-09 37.4 13.5 3.2e-09 36.7 13.5 1.3 1 0 0 1 1 1 1 MYND finger Ank_5 PF13857.6 OPL20498.1 - 2.9e-10 40.2 0.0 4.1e-09 36.5 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL20498.1 - 9.3e-07 29.4 0.0 2e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 OPL20498.1 - 5.1e-05 23.5 0.2 0.00052 20.4 0.1 2.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 OPL20498.1 - 0.00014 22.4 0.0 0.0016 19.0 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL20498.1 - 0.0011 19.3 0.0 0.006 17.0 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeat Cu-binding_MopE PF11617.8 OPL20499.1 - 0.0016 18.6 1.4 0.013 15.6 0.2 2.5 2 1 0 2 2 2 1 Putative metal-binding motif DUF1704 PF08014.11 OPL20500.1 - 4.8e-12 45.6 0.0 1e-11 44.5 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1704) Pkinase_Tyr PF07714.17 OPL20502.1 - 3.1e-29 102.0 0.0 4.5e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 OPL20502.1 - 2e-09 37.2 0.0 3.5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Guanylate_cyc PF00211.20 OPL20503.1 - 0.0014 18.3 0.0 0.0018 17.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Corona_RPol_N PF06478.13 OPL20504.1 - 0.11 11.5 0.1 0.12 11.3 0.1 1.1 1 0 0 1 1 1 0 Coronavirus RPol N-terminus SKG6 PF08693.10 OPL20508.1 - 2.3e-05 23.7 1.7 3.9e-05 23.0 1.7 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 OPL20508.1 - 0.0045 16.9 0.3 0.0045 16.9 0.3 2.0 2 0 0 2 2 2 1 TMEM154 protein family Amnionless PF14828.6 OPL20508.1 - 0.011 14.6 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 0 Amnionless Protocadherin PF08374.11 OPL20508.1 - 0.019 14.9 1.8 0.029 14.4 1.8 1.5 1 1 0 1 1 1 0 Protocadherin Orf78 PF06024.12 OPL20508.1 - 0.021 15.1 0.6 0.34 11.3 0.0 2.4 2 0 0 2 2 2 0 Orf78 (ac78) Syndecan PF01034.20 OPL20508.1 - 0.064 13.2 1.2 0.14 12.1 1.2 1.5 1 0 0 1 1 1 0 Syndecan domain EphA2_TM PF14575.6 OPL20508.1 - 0.093 13.6 0.9 0.15 12.9 0.9 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain WSS_VP PF12175.8 OPL20508.1 - 0.1 12.0 3.1 0.17 11.3 2.5 1.7 1 1 1 2 2 2 0 White spot syndrome virus structural envelope protein VP Presenilin PF01080.17 OPL20508.1 - 0.11 11.3 0.7 0.19 10.4 0.0 1.6 2 0 0 2 2 2 0 Presenilin Col_cuticle_N PF01484.17 OPL20508.1 - 0.88 9.7 3.7 2.1 8.5 3.7 1.7 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain YorP PF09629.10 OPL20508.1 - 2.1 8.6 0.0 2.1 8.6 0.0 2.8 3 2 0 3 3 3 0 YorP protein HECT PF00632.25 OPL20509.1 - 6.3e-37 127.7 0.0 6.9e-37 127.6 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AMOP PF03782.17 OPL20510.1 - 4.5e-18 65.7 1.6 4.5e-18 65.7 1.6 1.5 2 0 0 2 2 2 1 AMOP domain DUF4320 PF14208.6 OPL20511.1 - 0.2 11.7 0.2 0.75 9.9 0.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4320) Pox_Ag35 PF03286.14 OPL20511.1 - 0.72 9.6 8.3 0.39 10.5 6.2 1.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Ig_6 PF18452.1 OPL20512.1 - 0.14 11.8 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Podoplanin PF05808.11 OPL20512.1 - 1.8 8.6 11.8 0.069 13.3 5.8 1.7 2 0 0 2 2 2 0 Podoplanin DUF3377 PF11857.8 OPL20512.1 - 7.6 6.5 7.2 0.46 10.4 0.7 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3377) TBCC PF07986.12 OPL20514.1 - 1.2e-39 134.7 6.7 1.6e-39 134.4 6.7 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 OPL20514.1 - 8.5e-07 28.7 1.0 1e-06 28.4 1.0 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Coat_X PF07552.11 OPL20514.1 - 0.0039 17.0 0.6 0.11 12.4 0.1 2.4 2 0 0 2 2 2 1 Spore Coat Protein X and V domain Spt4 PF06093.13 OPL20514.1 - 0.15 12.2 14.6 0.49 10.5 4.5 2.5 2 1 0 2 2 2 0 Spt4/RpoE2 zinc finger HIPIP PF01355.17 OPL20514.1 - 0.86 10.0 11.4 20 5.6 4.4 3.1 2 1 1 3 3 3 0 High potential iron-sulfur protein PARP PF00644.20 OPL20515.1 - 9.7e-29 100.4 0.7 2.7e-27 95.6 0.7 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 OPL20515.1 - 0.0062 17.1 0.0 0.023 15.3 0.0 2.0 1 0 0 1 1 1 1 WWE domain Exotox-A_cataly PF09009.10 OPL20515.1 - 0.022 14.5 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Exotoxin A catalytic Myosin_head PF00063.21 OPL20520.1 - 1.5e-26 92.9 0.1 1.8e-26 92.6 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) TSP_3 PF02412.18 OPL20521.1 - 3.1e-05 23.6 25.8 0.00016 21.2 11.1 3.3 3 0 0 3 3 3 3 Thrombospondin type 3 repeat EGF_3 PF12947.7 OPL20521.1 - 0.0003 20.9 22.9 0.00045 20.3 13.7 3.1 3 0 0 3 3 3 2 EGF domain EGF_CA PF07645.15 OPL20521.1 - 0.0046 17.1 1.8 0.0046 17.1 1.8 3.1 3 0 0 3 3 3 2 Calcium-binding EGF domain EGF PF00008.27 OPL20521.1 - 0.025 14.9 8.5 0.025 14.9 8.5 3.4 3 1 0 3 3 3 0 EGF-like domain TRAPPC-Trs85 PF12739.7 OPL20523.1 - 8.1e-07 28.3 0.2 1.2e-06 27.8 0.2 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Defensin_big PF14862.6 OPL20525.1 - 4e-08 33.4 0.0 7.7e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Big defensin LMBR1 PF04791.16 OPL20525.1 - 0.022 13.7 0.1 0.026 13.5 0.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1489 PF07370.11 OPL20526.1 - 0.06 13.1 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) Ephrin_rec_like PF07699.13 OPL20527.1 - 8.5e-06 25.4 9.8 8.5e-06 25.4 9.8 9.2 5 4 3 8 8 8 3 Putative ephrin-receptor like TNFR_c6 PF00020.18 OPL20527.1 - 0.038 14.4 6.1 0.038 14.4 6.1 9.1 7 3 3 10 10 10 0 TNFR/NGFR cysteine-rich region PLAT PF01477.23 OPL20528.1 - 5.7e-06 26.9 0.1 1.3e-05 25.8 0.1 1.6 1 1 0 1 1 1 1 PLAT/LH2 domain I-set PF07679.16 OPL20529.1 - 6.6e-08 32.5 0.3 2.8e-07 30.5 0.0 2.3 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL20529.1 - 3.1e-07 30.9 2.8 8.6e-07 29.5 0.1 2.7 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 OPL20529.1 - 2e-05 24.9 0.8 0.00026 21.3 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Ig_6 PF18452.1 OPL20529.1 - 0.0002 20.9 0.0 0.01 15.4 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 OPL20529.1 - 0.00021 21.4 0.0 0.002 18.2 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Sushi PF00084.20 OPL20529.1 - 0.0015 19.1 3.3 0.02 15.5 2.9 2.4 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) V-set PF07686.17 OPL20529.1 - 0.025 14.7 0.2 0.1 12.8 0.0 2.2 2 1 1 3 3 3 0 Immunoglobulin V-set domain Receptor_2B4 PF11465.8 OPL20529.1 - 0.055 13.7 0.2 0.23 11.7 0.1 2.2 2 1 0 2 2 2 0 Natural killer cell receptor 2B4 TMEM154 PF15102.6 OPL20530.1 - 0.0085 16.0 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 TMEM154 protein family DUF4079 PF13301.6 OPL20530.1 - 0.071 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) Comm PF15957.5 OPL20530.1 - 0.11 12.8 0.2 0.21 11.9 0.2 1.4 1 0 0 1 1 1 0 Commissureless RQC PF09382.10 OPL20531.1 - 1e-20 73.6 0.1 1.6e-20 73.0 0.1 1.3 1 0 0 1 1 1 1 RQC domain RecQ_Zn_bind PF16124.5 OPL20531.1 - 1.3e-17 64.3 5.0 2.9e-17 63.1 5.0 1.7 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_C PF00271.31 OPL20531.1 - 3.4e-14 53.1 0.0 8e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain LZ3wCH PF18517.1 OPL20531.1 - 0.052 13.6 0.4 0.3 11.2 0.1 2.3 3 0 0 3 3 3 0 Leucine zipper with capping helix domain COesterase PF00135.28 OPL20532.1 - 1.1e-40 140.0 0.0 1.2e-40 139.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Peptidase_U49 PF10463.9 OPL20533.1 - 0.66 9.7 3.5 0.36 10.6 0.7 1.8 2 0 0 2 2 2 0 Peptidase U49 SET PF00856.28 OPL20535.1 - 5.3e-08 33.4 1.0 5.8e-08 33.3 0.2 1.4 2 0 0 2 2 2 1 SET domain PHTB1_N PF14727.6 OPL20536.1 - 4.5e-58 197.6 0.0 5.4e-58 197.3 0.0 1.0 1 0 0 1 1 1 1 PTHB1 N-terminus DUF2931 PF11153.8 OPL20536.1 - 0.048 13.3 0.0 0.069 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2931) fn3 PF00041.21 OPL20537.1 - 0.0034 17.7 0.7 0.0058 16.9 0.0 1.7 2 0 0 2 2 2 1 Fibronectin type III domain IFT20 PF14931.6 OPL20539.1 - 0.021 15.0 0.1 0.039 14.1 0.1 1.4 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 DUF5390 PF17365.2 OPL20539.1 - 0.082 13.2 0.0 0.12 12.7 0.0 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5390) Spectrin PF00435.21 OPL20540.1 - 1.1e-25 90.1 49.3 1.4e-09 38.4 9.3 5.6 5 1 1 6 6 6 4 Spectrin repeat Baculo_PEP_C PF04513.12 OPL20540.1 - 0.0038 17.3 11.5 1.5 8.9 0.1 5.2 3 2 1 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 OPL20540.1 - 0.044 14.0 6.6 21 5.4 0.0 5.4 5 1 2 7 7 7 0 Bacterial protein of unknown function (DUF948) Haem_degrading PF03928.14 OPL20540.1 - 0.13 12.3 0.1 0.46 10.5 0.0 2.0 2 0 0 2 2 2 0 Haem-degrading NPV_P10 PF05531.12 OPL20540.1 - 0.35 11.4 16.2 0.45 11.0 0.3 6.0 4 1 1 6 6 6 0 Nucleopolyhedrovirus P10 protein UPF0184 PF03670.13 OPL20540.1 - 0.56 10.6 5.4 1.8 9.0 0.1 3.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) Erythro-docking PF09277.11 OPL20540.1 - 0.67 9.9 3.3 12 5.9 0.1 3.4 3 0 0 3 3 3 0 Erythronolide synthase, docking Sec34 PF04136.15 OPL20540.1 - 1.3 8.8 24.0 0.63 9.9 2.6 4.9 4 1 0 5 5 5 0 Sec34-like family DUF1664 PF07889.12 OPL20540.1 - 1.4 9.0 25.0 1.7 8.7 0.6 5.5 2 1 4 6 6 6 0 Protein of unknown function (DUF1664) Prefoldin PF02996.17 OPL20540.1 - 3.3 7.6 26.6 2.2 8.2 0.0 7.7 5 4 4 10 10 10 0 Prefoldin subunit HWE_HK PF07536.14 OPL20540.1 - 5.4 7.8 8.9 17 6.2 0.4 3.7 3 1 1 4 4 4 0 HWE histidine kinase DUF4298 PF14131.6 OPL20540.1 - 8.4 6.4 28.8 0.85 9.6 0.1 5.7 5 2 1 6 6 6 0 Domain of unknown function (DUF4298) PQQ PF01011.21 OPL20541.1 - 0.069 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 PQQ enzyme repeat Ribosomal_L41 PF05162.13 OPL20542.1 - 0.0003 20.8 15.0 0.00066 19.7 15.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L41 DAO PF01266.24 OPL20543.1 - 3.7e-12 46.5 0.0 4.2e-12 46.3 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase QVR PF17064.5 OPL20544.1 - 4.7e-07 30.0 9.4 6e-07 29.6 9.4 1.1 1 0 0 1 1 1 1 Sleepless protein DUF3399 PF11879.8 OPL20544.1 - 0.079 13.3 2.9 0.12 12.8 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3399) HRM PF02793.22 OPL20545.1 - 4.6e-06 26.8 1.7 4.6e-06 26.8 1.7 2.0 2 1 0 2 2 2 1 Hormone receptor domain Ig_3 PF13927.6 OPL20545.1 - 0.00046 20.7 0.0 0.0008 20.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL20545.1 - 0.037 14.1 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain S1_2 PF13509.6 OPL20545.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 S1 domain SRCR PF00530.18 OPL20546.1 - 2.9e-11 43.7 0.0 2.9e-11 43.7 0.0 2.0 2 1 0 2 2 2 1 Scavenger receptor cysteine-rich domain EGF PF00008.27 OPL20546.1 - 5e-10 39.5 21.3 6.2e-07 29.6 8.1 2.9 2 1 0 2 2 2 2 EGF-like domain SRCR_2 PF15494.6 OPL20546.1 - 0.00014 22.4 0.0 0.00014 22.4 0.0 2.2 2 1 1 3 3 3 1 Scavenger receptor cysteine-rich domain EGF_2 PF07974.13 OPL20546.1 - 0.00022 21.5 26.5 0.00032 21.0 10.7 3.1 3 1 1 4 4 4 2 EGF-like domain hEGF PF12661.7 OPL20546.1 - 0.0003 21.3 7.4 0.0003 21.3 7.4 3.9 5 0 0 5 5 5 1 Human growth factor-like EGF MmgE_PrpD PF03972.14 OPL20546.1 - 0.29 9.6 0.0 0.34 9.4 0.0 1.0 1 0 0 1 1 1 0 MmgE/PrpD family Laminin_EGF PF00053.24 OPL20546.1 - 4.3 7.6 20.1 11 6.3 9.9 2.8 2 1 1 3 3 3 0 Laminin EGF domain Yeast_MT PF11403.8 OPL20546.1 - 5.2 7.7 17.6 4.3 8.0 0.2 2.9 2 1 0 2 2 2 0 Yeast metallothionein C1q PF00386.21 OPL20548.1 - 1.1e-19 70.9 0.1 1.3e-19 70.7 0.1 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL20548.1 - 6.2e-05 22.9 0.5 7.8e-05 22.6 0.5 1.1 1 0 0 1 1 1 1 BclA C-terminal domain OCRE PF17780.1 OPL20548.1 - 0.048 13.7 0.1 0.048 13.7 0.1 1.9 2 0 0 2 2 2 0 OCRE domain Kunitz_BPTI PF00014.23 OPL20549.1 - 4.9e-18 65.1 10.7 5.9e-18 64.9 10.7 1.1 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain PARP PF00644.20 OPL20550.1 - 9.9e-08 31.8 0.2 1.8e-07 30.9 0.2 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 OPL20550.1 - 0.00018 21.6 0.7 0.00029 20.9 0.7 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain SPK PF04435.18 OPL20550.1 - 0.0024 18.3 2.4 0.15 12.5 0.4 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF545) MSP7_C PF12948.7 OPL20550.1 - 0.096 13.3 1.1 0.24 12.1 0.1 1.9 1 1 0 2 2 2 0 MSP7-like protein C-terminal domain ApeC PF16977.5 OPL20550.1 - 0.14 12.0 1.1 0.93 9.4 0.2 2.0 1 1 1 2 2 2 0 C-terminal domain of apextrin Fibrinogen_C PF00147.18 OPL20551.1 - 8.6e-08 32.2 5.9 1.3e-07 31.7 5.9 1.3 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Peptidase_C97 PF05903.14 OPL20552.1 - 8.6e-20 71.1 0.0 1.2e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain CutC PF03932.14 OPL20552.1 - 0.21 11.0 0.0 0.28 10.6 0.0 1.1 1 0 0 1 1 1 0 CutC family Methyltransf_5 PF01795.19 OPL20553.1 - 3.4e-46 158.2 0.0 4.8e-46 157.7 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family RNA_pol_Rpb2_1 PF04563.15 OPL20553.1 - 0.0083 15.6 0.2 0.015 14.8 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit MTS PF05175.14 OPL20553.1 - 0.036 13.6 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 OPL20553.1 - 0.11 13.2 0.0 0.31 11.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_19 PF04672.12 OPL20553.1 - 0.14 11.7 0.0 0.28 10.6 0.0 1.3 1 1 0 1 1 1 0 S-adenosyl methyltransferase C1q PF00386.21 OPL20554.1 - 2.9e-05 24.3 0.2 4e-05 23.8 0.2 1.2 1 0 0 1 1 1 1 C1q domain Arf PF00025.21 OPL20555.1 - 6.7e-22 77.8 0.0 7.4e-22 77.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 OPL20555.1 - 0.001 18.3 0.0 0.0016 17.7 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 OPL20555.1 - 0.011 15.2 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit zf-B_box PF00643.24 OPL20556.1 - 2e-05 24.6 4.3 2e-05 24.6 4.3 1.8 2 0 0 2 2 1 1 B-box zinc finger CEBP_ZZ PF16366.5 OPL20556.1 - 0.00014 22.0 1.6 0.0002 21.5 0.5 1.8 2 0 0 2 2 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain PhaP_Bmeg PF09602.10 OPL20556.1 - 0.0068 16.4 11.3 0.14 12.1 0.6 2.2 1 1 1 2 2 2 2 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) FlgN PF05130.12 OPL20556.1 - 0.012 16.1 10.4 0.021 15.3 4.5 2.3 1 1 0 2 2 2 0 FlgN protein LPD39 PF18858.1 OPL20556.1 - 0.034 14.2 3.5 5.6 7.0 2.9 2.3 2 1 0 2 2 2 0 Large polyvalent protein associated domain 39 ApoO PF09769.9 OPL20556.1 - 0.044 13.7 2.8 5.6 6.9 0.0 2.4 2 0 0 2 2 2 0 Apolipoprotein O WXG100 PF06013.12 OPL20556.1 - 0.11 12.8 0.5 2.1 8.7 0.1 2.3 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Apolipoprotein PF01442.18 OPL20556.1 - 0.2 11.5 5.3 0.68 9.8 5.3 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF2935 PF11155.8 OPL20556.1 - 0.25 11.7 7.3 2.9 8.2 0.3 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF2935) DUF883 PF05957.13 OPL20556.1 - 0.27 11.8 4.5 11 6.8 4.4 2.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) Imm3 PF14425.6 OPL20556.1 - 0.44 10.6 6.3 1.2 9.2 0.5 3.0 2 1 1 3 3 3 0 Immunity protein Imm3 FAP206 PF12018.8 OPL20556.1 - 0.67 9.4 9.3 0.77 9.2 0.9 2.2 1 1 1 2 2 2 0 Domain of unknown function Tropomyosin_1 PF12718.7 OPL20556.1 - 0.67 10.1 16.9 1.1 9.4 11.2 2.4 1 1 1 2 2 2 0 Tropomyosin like ZYG-11_interact PF05884.12 OPL20556.1 - 1 8.7 4.0 9.3 5.6 4.1 2.0 1 1 0 1 1 1 0 Interactor of ZYG-11 FlxA PF14282.6 OPL20556.1 - 1.1 9.3 6.7 9.9 6.2 0.3 2.5 2 1 0 2 2 2 0 FlxA-like protein KIP1 PF07765.12 OPL20556.1 - 1.2 9.3 5.6 2.3 8.4 1.9 2.9 2 1 0 2 2 2 0 KIP1-like protein Stathmin PF00836.19 OPL20556.1 - 1.2 9.1 11.5 0.35 10.8 8.0 2.0 2 1 0 2 2 2 0 Stathmin family YlqD PF11068.8 OPL20556.1 - 1.3 9.4 10.3 14 6.1 6.6 2.3 2 0 0 2 2 2 0 YlqD protein YtxH PF12732.7 OPL20556.1 - 1.5 9.4 4.7 52 4.5 4.7 3.0 1 1 0 1 1 1 0 YtxH-like protein P4Ha_N PF08336.11 OPL20556.1 - 1.8 8.5 8.4 0.35 10.9 2.7 2.4 2 1 1 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF4407 PF14362.6 OPL20556.1 - 2.1 7.7 6.7 38 3.5 6.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 OPL20556.1 - 4.6 7.7 7.0 11 6.5 0.3 3.3 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 OPL20556.1 - 5.5 7.0 10.7 11 6.0 3.1 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 OPL20556.1 - 7 5.9 9.5 4.8 6.4 0.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) TMPIT PF07851.13 OPL20556.1 - 8.4 5.5 11.5 7.5 5.7 7.3 2.1 1 1 1 2 2 2 0 TMPIT-like protein Swi5 PF07061.11 OPL20556.1 - 9.7 6.4 11.2 2.1 8.5 2.3 3.5 2 1 2 4 4 4 0 Swi5 zinc_ribbon_2 PF13240.6 OPL20557.1 - 1.8e-07 30.6 12.0 0.0015 18.2 0.6 2.8 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 OPL20557.1 - 5.3e-07 29.6 7.5 2.3e-06 27.5 7.5 2.0 1 1 1 2 2 2 2 Double zinc ribbon Nudix_N_2 PF14803.6 OPL20557.1 - 0.00061 19.7 4.3 2.1 8.3 0.0 3.8 3 0 0 3 3 3 2 Nudix N-terminal zf-ribbon_3 PF13248.6 OPL20557.1 - 0.0086 15.5 11.5 0.016 14.6 4.3 2.6 2 0 0 2 2 2 2 zinc-ribbon domain zf-NADH-PPase PF09297.11 OPL20557.1 - 0.016 14.8 3.2 1.1 8.9 0.0 3.4 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain zinc-ribbons_6 PF07191.12 OPL20557.1 - 0.35 10.9 9.4 11 6.0 9.4 2.3 1 1 0 1 1 1 0 zinc-ribbons UPF0547 PF10571.9 OPL20557.1 - 0.38 10.9 10.3 3.9 7.7 3.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-C3HC4_3 PF13920.6 OPL20557.1 - 3.8 7.5 7.8 6 6.8 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-DNL PF05180.12 OPL20558.1 - 4.9e-29 100.1 1.2 4.9e-29 100.1 1.2 1.5 2 0 0 2 2 2 1 DNL zinc finger zf-ZPR1 PF03367.13 OPL20558.1 - 0.0023 17.8 0.8 0.0047 16.8 0.8 1.5 1 0 0 1 1 1 1 ZPR1 zinc-finger domain TF_Zn_Ribbon PF08271.12 OPL20558.1 - 0.0054 16.2 1.5 2.4 7.7 0.2 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 OPL20558.1 - 0.14 12.3 1.1 0.42 10.8 1.1 1.8 1 0 0 1 1 1 0 Zinc ribbon domain TFIIS_C PF01096.18 OPL20558.1 - 1.4 8.9 5.6 8.4 6.3 5.7 2.3 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS) TPR_1 PF00515.28 OPL20559.1 - 7.2e-08 31.9 2.7 1.8e-07 30.7 1.8 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 OPL20559.1 - 4.8e-07 29.4 1.6 9.6e-07 28.5 1.2 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 OPL20559.1 - 1.1e-05 25.9 0.1 1.5e-05 25.4 0.1 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 OPL20559.1 - 3.3e-05 24.1 0.4 0.0001 22.5 0.4 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 OPL20559.1 - 0.00013 22.1 1.7 0.00014 22.0 1.7 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 OPL20559.1 - 0.00056 20.5 0.0 0.00081 20.0 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 OPL20559.1 - 0.0006 19.8 1.5 0.0013 18.7 0.9 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 OPL20559.1 - 0.0016 18.9 1.7 0.0026 18.3 0.4 2.1 3 0 0 3 3 3 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 OPL20559.1 - 0.0023 17.9 0.4 0.0029 17.6 0.4 1.3 1 1 0 1 1 1 1 Putative TPR-like repeat NRDE-2 PF08424.10 OPL20559.1 - 0.003 16.8 0.2 0.0032 16.6 0.2 1.0 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference Fis1_TPR_C PF14853.6 OPL20559.1 - 0.0034 17.4 3.7 0.0052 16.8 1.1 2.4 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 OPL20559.1 - 0.013 15.4 0.5 0.082 13.0 0.5 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 OPL20559.1 - 0.019 15.3 0.3 0.046 14.1 0.3 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_3 PF07720.12 OPL20559.1 - 0.025 14.6 0.6 0.043 13.8 0.6 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 OPL20559.1 - 0.037 14.9 0.0 0.43 11.5 0.1 2.4 1 1 2 3 3 3 0 Tetratricopeptide repeat Sec1 PF00995.23 OPL20560.1 - 4.3e-25 89.0 0.9 4.7e-25 88.8 0.9 1.0 1 0 0 1 1 1 1 Sec1 family T_hemolysin PF12261.8 OPL20560.1 - 0.12 12.1 0.0 2.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Thermostable hemolysin DSL PF01414.19 OPL20561.1 - 0.0072 16.6 11.3 0.0072 16.6 11.3 3.3 2 1 0 2 2 2 1 Delta serrate ligand Laminin_EGF PF00053.24 OPL20561.1 - 0.79 9.9 47.8 0.22 11.7 8.9 4.0 1 1 3 4 4 4 0 Laminin EGF domain ATP-gua_PtransN PF02807.15 OPL20563.1 - 1.1e-25 89.8 0.0 1.6e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain ATP-gua_Ptrans PF00217.19 OPL20563.1 - 1.1e-06 28.3 0.1 1.9e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ACOX PF01756.19 OPL20565.1 - 4.3e-47 160.0 0.2 4.7e-47 159.9 0.2 1.0 1 0 0 1 1 1 1 Acyl-CoA oxidase Cdc6_C PF09079.11 OPL20565.1 - 0.15 12.0 0.3 0.67 10.0 0.0 1.9 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain Zip PF02535.22 OPL20566.1 - 7.7e-15 54.9 0.4 7.9e-15 54.9 0.4 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Melibiase PF02065.18 OPL20568.1 - 0.041 12.8 0.0 0.06 12.3 0.0 1.2 1 0 0 1 1 1 0 Melibiase Lysis_col PF02402.16 OPL20568.1 - 4.9 6.9 5.0 36 4.1 0.3 2.5 2 0 0 2 2 2 0 Lysis protein AAA_6 PF12774.7 OPL20569.1 - 9.4e-118 392.9 7.4 3.5e-112 374.6 3.3 3.0 2 1 0 2 2 2 2 Hydrolytic ATP binding site of dynein motor region RNA_helicase PF00910.22 OPL20569.1 - 0.00032 21.0 0.0 0.00086 19.7 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 OPL20569.1 - 0.00033 20.7 0.0 0.0027 17.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 OPL20569.1 - 0.0022 18.5 0.0 0.0057 17.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 OPL20569.1 - 0.05 13.3 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 OPL20569.1 - 0.059 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_16 PF13191.6 OPL20569.1 - 0.07 13.5 0.1 0.46 10.8 0.1 2.0 1 1 1 2 2 2 0 AAA ATPase domain SRP54 PF00448.22 OPL20569.1 - 0.082 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 OPL20569.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region TNF PF00229.18 OPL20570.1 - 0.017 15.0 0.2 0.073 13.0 0.0 2.1 2 0 0 2 2 2 0 TNF(Tumour Necrosis Factor) family MBOAT PF03062.19 OPL20571.1 - 3.4e-12 46.4 8.9 4.1e-12 46.1 8.9 1.2 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF866 PF05907.13 OPL20572.1 - 9.2e-37 126.3 0.0 1e-36 126.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) SopE_GEF PF07487.13 OPL20573.1 - 0.015 15.4 0.2 0.02 15.0 0.2 1.2 1 0 0 1 1 1 0 SopE GEF domain Sec3_C PF09763.9 OPL20573.1 - 0.017 13.5 0.3 0.02 13.3 0.3 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 ARGLU PF15346.6 OPL20573.1 - 0.066 13.1 0.9 0.086 12.7 0.9 1.1 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 COMPASS-Shg1 PF05205.12 OPL20573.1 - 0.13 13.0 0.8 0.18 12.5 0.8 1.2 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 DUF3819 PF12842.7 OPL20573.1 - 0.22 11.5 3.1 0.39 10.6 3.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3819) Acetyltransf_7 PF13508.7 OPL20574.1 - 1.3e-07 32.0 0.0 2.5e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 OPL20574.1 - 5.8e-06 26.5 0.0 9.4e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 OPL20574.1 - 1.9e-05 24.6 0.0 3.6e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 OPL20574.1 - 3e-05 24.1 0.0 0.00015 21.8 0.0 2.1 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 OPL20574.1 - 9.2e-05 22.1 0.0 0.0002 21.0 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase FR47 PF08445.10 OPL20574.1 - 0.0015 18.5 0.0 0.0049 16.8 0.0 1.8 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 OPL20574.1 - 0.013 16.2 0.0 0.026 15.2 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PIG-L PF02585.17 OPL20574.1 - 0.046 14.3 0.2 0.48 11.1 0.2 2.2 1 1 0 1 1 1 0 GlcNAc-PI de-N-acetylase Acetyltransf_CG PF14542.6 OPL20574.1 - 0.097 12.8 0.0 0.38 10.9 0.0 1.9 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase Actin PF00022.19 OPL20575.1 - 6.3e-10 38.2 0.0 1e-07 31.0 0.0 2.0 1 1 0 1 1 1 1 Actin DUF1376 PF07120.11 OPL20576.1 - 0.09 13.1 0.0 0.24 11.7 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1376) DUF3446 PF11928.8 OPL20577.1 - 0.0023 18.2 2.9 0.004 17.4 2.9 1.4 1 0 0 1 1 1 1 Early growth response N-terminal domain PRP1_N PF06424.12 OPL20577.1 - 0.13 12.6 0.6 0.23 11.8 0.3 1.5 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal DEAD PF00270.29 OPL20579.1 - 1e-17 64.5 0.0 1.6e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 OPL20579.1 - 2.7e-08 34.0 0.0 3.8e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Sec63 PF02889.16 OPL20579.1 - 6.5e-06 25.5 0.0 9.1e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain AAA_22 PF13401.6 OPL20579.1 - 0.0089 16.3 0.1 0.081 13.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 OPL20579.1 - 0.15 12.5 0.1 1 9.8 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) 7tm_1 PF00001.21 OPL20581.1 - 2.3e-27 96.0 11.2 3.6e-27 95.4 11.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Prominin PF05478.11 OPL20581.1 - 0.03 12.3 2.8 0.045 11.7 2.8 1.2 1 0 0 1 1 1 0 Prominin DUF4220 PF13968.6 OPL20581.1 - 8 5.8 8.8 0.34 10.3 0.7 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4220) Arena_RNA_pol PF06317.11 OPL20582.1 - 0.00097 16.5 0.1 0.0011 16.3 0.1 1.0 1 0 0 1 1 1 1 Arenavirus RNA polymerase DUF4746 PF15928.5 OPL20583.1 - 0.25 10.7 8.4 0.24 10.8 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_polI_A34 PF08208.11 OPL20583.1 - 1.1 9.3 20.8 1.3 9.1 20.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Presenilin PF01080.17 OPL20583.1 - 1.5 7.5 4.4 1.7 7.3 4.4 1.1 1 0 0 1 1 1 0 Presenilin Gal4_dimer PF03902.13 OPL20584.1 - 0.018 15.2 0.6 0.035 14.3 0.6 1.4 1 0 0 1 1 1 0 Gal4-like dimerisation domain Lact-deh-memb PF09330.11 OPL20584.1 - 0.096 12.0 0.4 0.12 11.7 0.4 1.1 1 0 0 1 1 1 0 D-lactate dehydrogenase, membrane binding Lebercilin PF15619.6 OPL20586.1 - 0.0006 19.5 6.6 0.0006 19.5 6.6 1.4 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.11 OPL20586.1 - 0.0028 16.6 6.1 0.0039 16.1 6.1 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein DHR10 PF18595.1 OPL20586.1 - 0.0077 16.3 9.2 0.015 15.4 6.5 2.1 1 1 1 2 2 2 1 Designed helical repeat protein 10 domain Fez1 PF06818.15 OPL20586.1 - 0.012 16.1 3.2 0.013 15.9 3.2 1.2 1 0 0 1 1 1 0 Fez1 Atg14 PF10186.9 OPL20586.1 - 0.067 12.3 3.7 0.067 12.3 3.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CCDC53 PF10152.9 OPL20586.1 - 0.34 11.3 5.3 0.63 10.4 5.3 1.4 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex Med9 PF07544.13 OPL20586.1 - 0.62 10.2 5.5 0.82 9.8 3.8 1.9 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Fib_alpha PF08702.10 OPL20586.1 - 0.72 10.0 7.1 0.96 9.6 7.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 OPL20586.1 - 0.76 9.0 7.0 1.2 8.3 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CCDC-167 PF15188.6 OPL20586.1 - 1 9.7 8.7 0.54 10.6 5.6 2.0 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 UPF0242 PF06785.11 OPL20586.1 - 4.4 7.4 10.1 7 6.7 10.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus XhlA PF10779.9 OPL20586.1 - 4.6 7.5 5.5 5.8 7.2 0.4 2.3 1 1 1 2 2 2 0 Haemolysin XhlA Ion_trans PF00520.31 OPL20587.1 - 1.6e-30 106.2 0.3 9.9e-28 97.0 0.1 2.1 2 0 0 2 2 2 2 Ion transport protein Na_trans_assoc PF06512.13 OPL20587.1 - 1.6e-08 35.1 5.0 2.5e-08 34.5 5.0 1.2 1 0 0 1 1 1 1 Sodium ion transport-associated zf-C3HC4_3 PF13920.6 OPL20588.1 - 6.5e-14 51.5 7.5 1.2e-13 50.7 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL20588.1 - 3.1e-05 23.8 10.2 3.7e-05 23.5 8.4 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 OPL20588.1 - 4.7e-05 23.2 5.8 4.7e-05 23.2 5.8 2.4 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL20588.1 - 0.00045 20.5 11.7 0.00065 20.0 10.2 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 OPL20588.1 - 0.001 19.0 8.5 0.001 19.0 8.5 1.9 1 1 1 2 2 2 1 zinc-RING finger domain Linocin_M18 PF04454.12 OPL20588.1 - 0.0036 16.6 0.1 0.0048 16.2 0.1 1.1 1 0 0 1 1 1 1 Encapsulating protein for peroxidase UBA PF00627.31 OPL20588.1 - 0.082 12.8 0.0 0.19 11.7 0.0 1.6 2 0 0 2 2 2 0 UBA/TS-N domain zf-C3HC4_4 PF15227.6 OPL20588.1 - 0.11 12.7 9.7 0.71 10.1 3.8 2.8 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 OPL20588.1 - 0.13 12.0 0.9 0.13 12.0 0.9 3.0 3 1 0 3 3 3 0 RING-like zinc finger RecR PF02132.15 OPL20588.1 - 0.31 10.6 0.2 0.31 10.6 0.2 2.6 2 1 0 2 2 2 0 RecR protein zf-RING_UBOX PF13445.6 OPL20588.1 - 0.56 10.3 9.2 0.65 10.1 3.8 2.8 3 0 0 3 3 3 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 OPL20588.1 - 0.67 9.8 13.6 0.38 10.6 9.1 2.5 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Sin_N PF04801.13 OPL20589.1 - 0.036 13.3 6.0 0.045 13.0 6.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region YgaB PF14182.6 OPL20589.1 - 0.18 12.2 4.1 0.33 11.4 4.1 1.4 1 0 0 1 1 1 0 YgaB-like protein DUF810 PF05664.11 OPL20589.1 - 0.19 10.2 6.5 0.28 9.7 6.5 1.1 1 0 0 1 1 1 0 Plant family of unknown function (DUF810) GP3_package PF16677.5 OPL20591.1 - 0.05 13.7 0.3 0.92 9.7 0.2 2.2 2 0 0 2 2 2 0 DNA-packaging protein gp3 Sugar_tr PF00083.24 OPL20592.1 - 2.4e-09 36.6 0.2 3.2e-09 36.2 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter PH_11 PF15413.6 OPL20592.1 - 0.06 13.8 0.0 0.091 13.2 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain fn3 PF00041.21 OPL20593.1 - 0.024 15.0 3.6 0.45 10.9 0.1 3.0 3 0 0 3 3 3 0 Fibronectin type III domain ADP_ribosyl_GH PF03747.14 OPL20594.1 - 1.1e-39 137.0 0.0 1.3e-39 136.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase SPRY PF00622.28 OPL20596.1 - 0.0017 18.5 0.0 0.096 12.8 0.0 2.2 1 1 0 1 1 1 1 SPRY domain IDO PF01231.18 OPL20597.1 - 3.1e-36 125.1 6.4 2.3e-35 122.3 6.4 1.9 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase YkyA PF10368.9 OPL20597.1 - 0.0083 15.8 0.4 0.0097 15.6 0.4 1.2 1 0 0 1 1 1 1 Putative cell-wall binding lipoprotein AbiJ_NTD5 PF18865.1 OPL20597.1 - 0.096 12.5 0.1 0.45 10.3 0.1 1.9 1 1 1 2 2 2 0 AbiJ N-terminal domain 5 DUF1456 PF07308.13 OPL20597.1 - 0.1 13.0 0.1 0.2 12.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1456) DUF2201 PF09967.9 OPL20597.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 1 0 1 1 1 0 VWA-like domain (DUF2201) SUR7 PF06687.12 OPL20598.1 - 0.018 14.7 0.2 0.023 14.3 0.2 1.1 1 0 0 1 1 1 0 SUR7/PalI family CAV_VP3 PF04771.12 OPL20598.1 - 0.023 14.8 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 Chicken anaemia virus VP-3 protein TMEM154 PF15102.6 OPL20598.1 - 0.043 13.7 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family ECSCR PF15820.5 OPL20598.1 - 0.047 13.5 0.0 0.069 13.0 0.0 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator ATP1G1_PLM_MAT8 PF02038.16 OPL20598.1 - 0.095 12.1 0.3 0.095 12.1 0.3 1.9 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family DUF5305 PF17231.2 OPL20598.1 - 0.1 12.0 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Vpu PF00558.19 OPL20598.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Vpu protein LRR19-TM PF15176.6 OPL20598.1 - 0.15 12.0 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DAG1 PF05454.11 OPL20598.1 - 0.17 11.2 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) EphA2_TM PF14575.6 OPL20598.1 - 0.18 12.7 0.0 0.35 11.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain GCP_N_terminal PF17681.1 OPL20601.1 - 2.4e-51 175.2 0.0 3.2e-51 174.8 0.0 1.0 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Ppx-GppA PF02541.16 OPL20601.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family DUF4071 PF13281.6 OPL20602.1 - 1.1e-100 337.3 0.0 2.3e-100 336.2 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4071) TFIIA_gamma_N PF02268.16 OPL20603.1 - 0.0053 16.8 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain COR PF16095.5 OPL20604.1 - 2.1e-14 53.8 1.2 4.3e-14 52.8 1.2 1.5 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain RAC_head PF16717.5 OPL20604.1 - 0.08 13.9 0.2 0.28 12.2 0.2 1.9 1 0 0 1 1 1 0 Ribosome-associated complex head domain zf-C3HC4 PF00097.25 OPL20605.1 - 0.00033 20.5 3.4 0.00033 20.5 3.4 3.7 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 OPL20605.1 - 0.00061 19.7 11.1 0.00061 19.7 11.1 3.6 3 1 1 4 4 4 2 zinc-RING finger domain zf-RING_11 PF17123.5 OPL20605.1 - 0.00067 19.3 5.9 0.0018 18.0 4.4 2.7 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 OPL20605.1 - 0.0014 18.4 5.8 0.17 11.7 2.1 3.1 2 1 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 OPL20605.1 - 0.0017 18.1 8.4 0.0017 18.1 8.4 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL20605.1 - 0.0089 16.3 8.9 0.0089 16.3 8.9 3.6 3 1 0 3 3 3 2 Ring finger domain Romo1 PF10247.9 OPL20607.1 - 2e-27 95.3 16.8 2.4e-27 95.1 16.8 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 OPL20607.1 - 0.00087 19.6 6.8 0.00097 19.5 6.8 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family m_DGTX_Dc1a_b_c PF17491.2 OPL20609.1 - 0.017 15.8 0.3 0.043 14.5 0.3 1.7 1 0 0 1 1 1 0 Spider Toxins mu-diguetoxin-1 a, b and c DUF1464 PF07318.12 OPL20609.1 - 0.059 12.5 0.0 0.076 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) Lectin_C PF00059.21 OPL20610.1 - 3e-18 66.5 5.2 3e-18 66.5 5.2 1.5 2 0 0 2 2 2 1 Lectin C-type domain ETRAMP PF09716.10 OPL20610.1 - 0.00029 20.8 0.8 0.00048 20.1 0.8 1.3 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) DUF4971 PF16341.5 OPL20610.1 - 0.07 13.0 0.0 0.11 12.3 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4971) Frataxin_Cyay PF01491.16 OPL20610.1 - 0.62 10.2 5.5 0.12 12.4 1.6 1.9 2 1 0 2 2 2 0 Frataxin-like domain Flt3_lig PF02947.14 OPL20611.1 - 0.058 13.6 4.8 0.035 14.3 2.6 1.7 1 1 0 1 1 1 0 flt3 ligand CENP-F_leu_zip PF10473.9 OPL20611.1 - 0.14 12.2 45.4 0.089 12.8 13.8 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 OPL20611.1 - 0.18 11.9 22.3 1.5 8.9 3.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 OPL20611.1 - 0.3 11.3 32.6 0.81 9.9 13.7 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Leu_zip PF15294.6 OPL20611.1 - 0.43 10.1 31.4 0.011 15.2 14.5 2.1 1 1 1 2 2 2 0 Leucine zipper GAS PF13851.6 OPL20611.1 - 0.48 9.7 39.3 0.022 14.1 22.1 2.9 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 OPL20611.1 - 0.48 10.5 39.3 1.8 8.6 4.2 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3584 PF12128.8 OPL20611.1 - 0.9 7.0 28.9 1 6.8 28.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4349 PF14257.6 OPL20611.1 - 1.7 8.0 16.3 6.2 6.2 8.8 3.1 2 2 0 2 2 2 0 Domain of unknown function (DUF4349) CASP_C PF08172.12 OPL20611.1 - 3 7.1 21.7 7.7e+02 -0.8 21.7 2.8 1 1 0 1 1 1 0 CASP C terminal NPV_P10 PF05531.12 OPL20611.1 - 3 8.4 13.6 0.84 10.2 1.4 3.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Spc7 PF08317.11 OPL20611.1 - 3.6 6.4 41.1 9.4 5.0 13.7 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4200 PF13863.6 OPL20611.1 - 8.6 6.8 42.9 17 5.8 27.6 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Fez1 PF06818.15 OPL20611.1 - 8.8 6.7 32.8 2.3e+02 2.1 32.8 2.2 1 1 0 1 1 1 0 Fez1 zf-RanBP PF00641.18 OPL20612.1 - 5.4e-23 80.0 20.3 3.6e-09 35.8 1.6 3.4 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others Nup153 PF08604.10 OPL20612.1 - 1.1e-05 24.5 7.0 1.5e-05 24.0 7.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup153-like Vps36-NZF-N PF16988.5 OPL20612.1 - 0.0047 16.3 11.8 0.67 9.4 0.2 3.8 3 0 0 3 3 3 2 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 OPL20612.1 - 0.087 12.9 10.7 0.41 10.7 0.3 3.8 3 1 0 3 3 3 0 Sec23/Sec24 zinc finger Cytochrom_c3_2 PF14537.6 OPL20612.1 - 0.097 13.1 4.8 0.84 10.1 1.9 2.3 2 0 0 2 2 2 0 Cytochrome c3 Fer4 PF00037.27 OPL20612.1 - 2.3 8.1 11.2 16 5.5 0.4 3.8 3 0 0 3 3 3 0 4Fe-4S binding domain DUF3615 PF12274.8 OPL20612.1 - 2.6 8.6 7.9 14 6.3 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3615) zf-CXXC PF02008.20 OPL20612.1 - 3.2 7.8 17.0 3.3 7.8 1.5 3.4 3 0 0 3 3 3 0 CXXC zinc finger domain Macoilin PF09726.9 OPL20612.1 - 3.4 6.1 5.0 3.6 6.0 5.0 1.1 1 0 0 1 1 1 0 Macoilin family zf-C3HC4_3 PF13920.6 OPL20612.1 - 6.7 6.6 13.0 5.6 6.9 1.1 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Ig_mannosidase PF17753.1 OPL20613.1 - 8e-20 70.4 0.3 8e-20 70.4 0.3 2.0 2 0 0 2 2 2 1 Ig-fold domain Mannosidase_ig PF17786.1 OPL20613.1 - 0.0045 17.6 0.2 0.011 16.3 0.0 1.7 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain TPR_20 PF14561.6 OPL20614.1 - 0.00048 20.4 0.5 0.007 16.7 0.1 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 OPL20614.1 - 0.0039 17.7 1.5 0.0074 16.8 0.0 2.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 OPL20614.1 - 0.034 14.9 0.2 0.15 12.9 0.0 2.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 OPL20614.1 - 0.075 13.5 0.1 23 5.7 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_5 PF12688.7 OPL20614.1 - 0.12 12.6 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Tetratrico peptide repeat LBP_BPI_CETP_C PF02886.17 OPL20615.1 - 7.3e-29 100.9 0.0 9.2e-29 100.6 0.0 1.1 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain FOXO_KIX_bdg PF16675.5 OPL20615.1 - 0.016 15.5 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 KIX-binding domain of forkhead box O, CR2 Glyco_hydro_3 PF00933.21 OPL20616.1 - 1.1e-08 34.8 0.0 6e-08 32.4 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acyl-CoA_dh_1 PF00441.24 OPL20617.1 - 1.3e-21 77.4 0.8 1.4e-21 77.3 0.8 1.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 OPL20617.1 - 1.7e-07 31.6 0.1 1.9e-07 31.4 0.1 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain UPF0728 PF15092.6 OPL20618.1 - 7.5e-07 28.9 0.0 8.2e-07 28.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0728 VWA_N PF08399.11 OPL20619.1 - 2.4e-09 37.7 0.2 1.1e-08 35.6 0.2 2.0 1 1 0 1 1 1 1 VWA N-terminal VWA_2 PF13519.6 OPL20619.1 - 6.9e-06 26.7 0.1 1.5e-05 25.6 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 OPL20619.1 - 0.015 15.6 0.1 0.037 14.3 0.1 1.6 2 0 0 2 2 2 0 von Willebrand factor type A domain vWA-TerF-like PF10138.9 OPL20619.1 - 0.031 14.4 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus MIEAP PF16026.5 OPL20620.1 - 2.9e-05 24.4 0.1 2.9e-05 24.4 0.1 1.9 2 0 0 2 2 2 1 Mitochondria-eating protein Spc7 PF08317.11 OPL20620.1 - 4.3e-05 22.5 6.4 5.5e-05 22.2 6.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 OPL20620.1 - 0.0022 18.2 6.8 0.021 15.0 3.3 2.4 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding HMMR_C PF15908.5 OPL20620.1 - 0.011 16.0 5.8 0.018 15.3 5.8 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal DnaB_C PF03796.15 OPL20620.1 - 0.019 14.3 2.9 0.33 10.2 0.1 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain DivIC PF04977.15 OPL20620.1 - 0.049 13.4 10.9 0.18 11.6 6.6 2.5 1 1 1 2 2 2 0 Septum formation initiator Scaffolding_pro PF11418.8 OPL20620.1 - 0.14 12.8 3.6 0.33 11.5 3.4 1.9 1 1 1 2 2 2 0 Phi29 scaffolding protein FapA PF03961.13 OPL20620.1 - 0.14 10.7 6.3 0.19 10.3 6.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 OPL20620.1 - 0.19 11.1 2.2 0.24 10.7 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 OPL20620.1 - 0.31 11.3 10.0 0.24 11.6 7.8 1.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4337 PF14235.6 OPL20620.1 - 1.6 8.9 4.8 2.6 8.1 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4140 PF13600.6 OPL20620.1 - 2.3 8.7 8.4 8.3 6.9 0.2 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) BST2 PF16716.5 OPL20620.1 - 6.3 7.5 15.7 0.76 10.4 8.0 2.7 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 TMPIT PF07851.13 OPL20620.1 - 6.7 5.9 7.8 4.7 6.4 6.5 1.3 1 1 0 1 1 1 0 TMPIT-like protein Prefoldin_2 PF01920.20 OPL20620.1 - 6.8 6.7 15.0 1.3 9.0 8.5 2.6 2 1 1 3 3 3 0 Prefoldin subunit Sas6_CC PF18594.1 OPL20620.1 - 7.7 6.4 13.4 1.1 9.1 0.1 3.2 4 0 0 4 4 4 0 Sas6/XLF/XRCC4 coiled-coil domain Peptidase_M13_N PF05649.13 OPL20621.1 - 2.6e-27 96.5 0.0 3.1e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Act-Frag_cataly PF09192.10 OPL20621.1 - 0.041 13.3 0.2 0.054 12.9 0.2 1.2 1 0 0 1 1 1 0 Actin-fragmin kinase, catalytic FERM_C PF09380.10 OPL20621.1 - 0.1 13.0 0.1 0.23 11.8 0.1 1.6 2 0 0 2 2 2 0 FERM C-terminal PH-like domain DUF2197 PF09963.9 OPL20623.1 - 0.024 14.9 0.0 0.043 14.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) CBM_14 PF01607.24 OPL20625.1 - 6.4e-35 119.1 22.8 1.5e-13 50.6 4.0 3.1 3 0 0 3 3 3 3 Chitin binding Peritrophin-A domain Pico_P2A PF00947.19 OPL20625.1 - 0.059 13.4 0.1 4.3 7.4 0.0 2.5 3 0 0 3 3 3 0 Picornavirus core protein 2A TNFR_c6 PF00020.18 OPL20625.1 - 0.16 12.4 0.6 0.16 12.4 0.6 3.9 5 1 0 5 5 5 0 TNFR/NGFR cysteine-rich region DUF5401 PF17380.2 OPL20625.1 - 4.3 5.3 7.4 5.7 4.9 0.1 2.9 2 1 2 4 4 4 0 Family of unknown function (DUF5401) Peptidase_M13_N PF05649.13 OPL20626.1 - 5.6e-33 115.2 0.3 6.4e-33 115.0 0.3 1.0 1 0 0 1 1 1 1 Peptidase family M13 FKBP_C PF00254.28 OPL20627.1 - 6.1e-30 103.4 0.0 9.2e-30 102.8 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase VWA PF00092.28 OPL20628.1 - 1.4e-37 129.6 0.1 1.7e-37 129.3 0.1 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL20628.1 - 7.2e-14 52.3 0.0 1.1e-13 51.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 OPL20628.1 - 3.6e-06 26.5 0.0 5.3e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 OPL20628.1 - 0.01 15.8 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Yeast-kill-tox PF09207.11 OPL20628.1 - 0.099 13.3 0.1 2.1 9.1 0.0 2.2 2 0 0 2 2 2 0 Yeast killer toxin HEAT PF02985.22 OPL20629.1 - 1.7e-07 30.9 0.1 0.22 11.9 0.0 3.7 3 0 0 3 3 3 3 HEAT repeat Cnd1 PF12717.7 OPL20629.1 - 0.00012 22.2 0.6 0.0032 17.5 0.7 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 OPL20629.1 - 0.0002 20.1 1.7 0.00035 19.3 1.6 1.4 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 OPL20629.1 - 0.00093 19.5 0.1 0.23 11.9 0.0 2.7 1 1 1 2 2 2 2 HEAT repeats CLASP_N PF12348.8 OPL20629.1 - 0.082 12.5 0.1 11 5.5 0.0 2.6 1 1 2 3 3 3 0 CLASP N terminal Fer2 PF00111.27 OPL20631.1 - 0.0059 16.5 0.0 0.0079 16.1 0.0 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain LANC_like PF05147.13 OPL20632.1 - 1.3e-18 66.7 0.3 1.9e-18 66.1 0.3 1.3 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Fis1_TPR_N PF14852.6 OPL20632.1 - 0.098 12.3 1.0 0.17 11.6 0.2 1.9 2 0 0 2 2 2 0 Fis1 N-terminal tetratricopeptide repeat RHS_repeat PF05593.14 OPL20633.1 - 0.0004 20.8 0.7 1 10.0 0.0 3.4 3 0 0 3 3 3 2 RHS Repeat MORN_2 PF07661.13 OPL20633.1 - 0.29 11.5 4.6 16 6.1 0.2 4.2 3 1 0 3 3 3 0 MORN repeat variant DUF4595 PF15283.6 OPL20633.1 - 3.7 7.6 14.3 23 5.0 9.2 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4595) with porin-like fold zf-CCHC PF00098.23 OPL20634.1 - 6.6e-05 22.8 16.0 0.003 17.6 2.1 3.1 3 0 0 3 3 3 2 Zinc knuckle Retrotrans_gag PF03732.17 OPL20634.1 - 0.047 14.0 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein ig PF00047.25 OPL20634.1 - 0.077 13.2 1.7 0.53 10.5 0.3 2.7 1 1 1 2 2 2 0 Immunoglobulin domain zf-CCHC_2 PF13696.6 OPL20634.1 - 0.46 10.3 8.5 2.8 7.8 0.6 2.6 2 0 0 2 2 2 0 Zinc knuckle DUF4071 PF13281.6 OPL20635.1 - 1.5e-10 40.7 0.1 1.6e-10 40.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4071) DUF3683 PF12447.8 OPL20635.1 - 0.042 14.0 0.1 0.054 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3683) AMP-binding PF00501.28 OPL20637.1 - 1e-11 44.1 0.1 1.1e-11 44.0 0.1 1.0 1 0 0 1 1 1 1 AMP-binding enzyme PsbH PF00737.20 OPL20637.1 - 0.0096 15.6 0.3 0.017 14.8 0.3 1.4 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein Roc PF08477.13 OPL20638.1 - 5.5e-16 58.9 1.6 1e-08 35.4 0.1 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL20638.1 - 1.3e-07 31.4 1.3 0.0097 15.5 0.2 2.3 2 0 0 2 2 2 2 Ras family Arf PF00025.21 OPL20638.1 - 1.6e-06 27.7 0.1 4.6e-06 26.2 0.1 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_16 PF13191.6 OPL20638.1 - 0.00055 20.4 0.2 0.00074 19.9 0.2 1.5 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 OPL20638.1 - 0.0012 18.9 3.4 0.011 15.7 3.4 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 OPL20638.1 - 0.0014 18.9 0.2 0.0022 18.3 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 OPL20638.1 - 0.0014 18.2 0.0 0.0024 17.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region Pox_A32 PF04665.12 OPL20638.1 - 0.0024 17.4 0.1 0.14 11.6 0.0 2.2 2 0 0 2 2 2 1 Poxvirus A32 protein Septin PF00735.18 OPL20638.1 - 0.0049 16.2 0.9 0.0052 16.1 0.0 1.6 2 0 0 2 2 2 1 Septin ABC_tran PF00005.27 OPL20638.1 - 0.0091 16.5 3.1 0.023 15.2 3.1 1.7 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 OPL20638.1 - 0.01 15.8 0.7 0.019 14.9 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 OPL20638.1 - 0.011 15.1 0.1 0.28 10.5 0.0 2.3 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA PF00004.29 OPL20638.1 - 0.023 15.1 0.0 0.046 14.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 OPL20638.1 - 0.025 14.8 0.3 0.038 14.2 0.3 1.6 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 OPL20638.1 - 0.027 14.4 0.1 0.062 13.2 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TniB PF05621.11 OPL20638.1 - 0.029 13.8 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein PqqD PF05402.12 OPL20638.1 - 0.035 14.4 0.2 0.12 12.6 0.0 2.0 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) AAA_18 PF13238.6 OPL20638.1 - 0.049 14.2 0.1 0.091 13.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 OPL20638.1 - 0.051 13.2 0.1 0.14 11.7 0.1 1.8 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 OPL20638.1 - 0.06 13.3 2.5 0.17 11.7 2.5 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 OPL20638.1 - 0.061 13.4 0.1 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 OPL20638.1 - 0.063 13.0 0.1 0.17 11.7 0.0 1.7 2 0 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 OPL20638.1 - 0.12 12.4 2.9 0.25 11.4 2.9 1.8 1 1 0 1 1 1 0 Dynamin family Syntaxin-6_N PF09177.11 OPL20638.1 - 0.2 12.2 3.5 1.6 9.3 2.8 2.3 1 1 0 1 1 1 0 Syntaxin 6, N-terminal SRCR PF00530.18 OPL20639.1 - 0.00028 21.3 0.2 0.00061 20.3 0.1 1.7 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain VWA_N PF08399.11 OPL20640.1 - 8.4e-06 26.3 1.6 1.5e-05 25.5 0.1 2.0 2 1 0 2 2 2 1 VWA N-terminal DUF1869 PF08956.10 OPL20640.1 - 0.025 14.5 0.1 0.035 14.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1869) Sld7_N PF18636.1 OPL20640.1 - 0.049 14.0 0.4 0.1 13.0 0.1 1.6 2 0 0 2 2 2 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain bZIP_1 PF00170.21 OPL20642.1 - 2.2e-09 37.3 15.3 4.6e-09 36.2 15.3 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 OPL20642.1 - 2e-08 34.2 14.7 2e-08 34.2 14.7 1.6 2 0 0 2 2 2 1 Basic region leucine zipper DUF4643 PF15485.6 OPL20642.1 - 0.0062 16.4 0.5 0.0063 16.4 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4643) bZIP_Maf PF03131.17 OPL20642.1 - 0.012 16.2 11.8 0.012 16.2 11.8 1.6 1 1 0 1 1 1 0 bZIP Maf transcription factor ZapB PF06005.12 OPL20642.1 - 0.029 14.8 5.8 0.029 14.8 5.8 2.2 1 1 1 2 2 2 0 Cell division protein ZapB DUF1465 PF07323.12 OPL20642.1 - 0.066 13.0 4.6 0.067 13.0 3.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1465) IFP_35_N PF07334.13 OPL20642.1 - 0.12 12.5 1.0 0.12 12.5 1.0 2.2 2 1 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Leu_zip PF15294.6 OPL20642.1 - 0.14 11.6 9.6 0.15 11.6 7.4 1.9 1 1 1 2 2 2 0 Leucine zipper PspB PF06667.12 OPL20642.1 - 0.18 11.9 4.2 0.21 11.7 3.3 1.6 1 1 0 1 1 1 0 Phage shock protein B GIT_CC PF16559.5 OPL20642.1 - 0.3 11.0 3.1 0.42 10.5 0.7 2.4 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor GvpL_GvpF PF06386.11 OPL20642.1 - 0.32 10.9 5.2 0.41 10.5 5.2 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DivIC PF04977.15 OPL20642.1 - 1.3 8.8 7.6 0.72 9.7 4.5 2.1 1 1 0 1 1 1 0 Septum formation initiator WAP PF00095.21 OPL20644.1 - 3.2e-06 27.4 13.6 3.2e-06 27.4 13.6 2.1 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' DHR10 PF18595.1 OPL20645.1 - 0.0093 16.0 3.5 0.041 13.9 3.7 1.5 1 1 0 1 1 1 1 Designed helical repeat protein 10 domain TMPIT PF07851.13 OPL20645.1 - 0.013 14.8 0.4 0.015 14.6 0.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein WSC PF01822.19 OPL20645.1 - 0.013 15.7 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 WSC domain DivIC PF04977.15 OPL20645.1 - 0.02 14.7 0.9 0.03 14.1 0.9 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF2098 PF09871.9 OPL20645.1 - 0.022 15.1 0.4 0.035 14.5 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) DUF3450 PF11932.8 OPL20645.1 - 0.12 11.7 2.3 0.17 11.2 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RNase_Zc3h12a PF11977.8 OPL20646.1 - 4.4e-29 101.3 0.1 1.9e-28 99.2 0.1 2.1 1 1 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain DUF4932 PF16286.5 OPL20646.1 - 0.045 13.0 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4932) HSP70 PF00012.20 OPL20647.1 - 0.0028 15.9 0.0 0.0066 14.7 0.0 1.5 1 1 0 1 1 1 1 Hsp70 protein Corona_S2 PF01601.16 OPL20649.1 - 0.038 12.5 0.3 0.051 12.1 0.3 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein WW PF00397.26 OPL20650.1 - 1.4e-06 28.2 3.1 3e-06 27.2 3.1 1.5 1 0 0 1 1 1 1 WW domain AnfO_nitrog PF09582.10 OPL20650.1 - 0.01 15.2 3.8 0.022 14.1 3.8 1.5 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) Patatin PF01734.22 OPL20651.1 - 1.9e-09 38.0 0.3 2.3e-09 37.7 0.3 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase DUF2336 PF10098.9 OPL20651.1 - 0.062 12.8 0.0 0.075 12.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) Death PF00531.22 OPL20653.1 - 0.0062 16.7 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Death domain Transglut_core PF01841.19 OPL20653.1 - 0.0083 16.6 0.0 0.013 15.9 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily Cadherin PF00028.17 OPL20654.1 - 3e-07 30.8 0.2 1.1e-05 25.8 0.1 2.2 2 0 0 2 2 2 1 Cadherin domain Cadherin_4 PF17803.1 OPL20654.1 - 0.0074 16.9 7.2 0.58 10.8 1.1 2.2 2 0 0 2 2 2 2 Bacterial cadherin-like domain Big_9 PF17963.1 OPL20654.1 - 0.022 15.5 8.1 0.24 12.2 1.8 2.3 2 0 0 2 2 2 0 Bacterial Ig domain PCC_BT PF18140.1 OPL20654.1 - 0.07 13.5 0.0 0.37 11.1 0.0 1.8 1 1 1 2 2 2 0 Propionyl-coenzyme A carboxylase BT domain PLAC9 PF15205.6 OPL20655.1 - 0.16 12.4 0.1 0.41 11.1 0.1 1.7 1 0 0 1 1 1 0 Placenta-specific protein 9 Taq-exonuc PF09281.10 OPL20655.1 - 0.69 9.9 7.2 18 5.3 0.0 3.9 1 1 3 4 4 4 0 Taq polymerase, exonuclease TIG PF01833.24 OPL20656.1 - 8.5e-12 45.0 11.8 5.3e-06 26.4 0.5 3.1 2 1 1 3 3 3 3 IPT/TIG domain TIG_2 PF18020.1 OPL20656.1 - 0.17 12.5 0.9 2.5 8.8 0.0 2.4 2 1 0 2 2 2 0 TIG domain found in plexin Lipase_3 PF01764.25 OPL20657.1 - 2.9e-13 49.9 0.0 3.4e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 OPL20657.1 - 0.0094 16.6 0.0 0.0099 16.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 OPL20657.1 - 0.041 13.5 0.0 0.046 13.4 0.0 1.1 1 0 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 OPL20657.1 - 0.055 12.7 0.0 0.064 12.5 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 OPL20657.1 - 0.076 12.9 0.0 0.088 12.7 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold PAF-AH_p_II PF03403.13 OPL20657.1 - 0.13 10.8 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II LRR_6 PF13516.6 OPL20661.1 - 4.8e-16 57.4 6.1 0.0062 16.5 0.0 7.2 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 OPL20661.1 - 2.6e-10 40.4 1.5 0.017 15.6 0.1 4.5 2 2 3 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 OPL20661.1 - 0.00063 19.5 2.2 0.55 10.0 0.0 3.6 3 2 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 OPL20661.1 - 0.00073 19.7 7.1 2.4 9.0 0.1 5.9 5 2 0 5 5 5 1 Leucine Rich Repeat DUF433 PF04255.14 OPL20661.1 - 0.024 14.5 0.0 0.091 12.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF433) SAM_Ste50p PF09235.10 OPL20661.1 - 0.087 13.1 4.0 0.18 12.1 0.1 2.9 3 2 0 3 3 3 0 Ste50p, sterile alpha motif DUF812 PF05667.11 OPL20662.1 - 0.0036 16.3 9.4 0.0041 16.1 9.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) HIP1_clath_bdg PF16515.5 OPL20662.1 - 0.38 11.4 14.0 1.5 9.4 2.9 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 PF16716.5 OPL20662.1 - 0.4 11.3 8.2 2.6 8.7 1.1 2.6 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 MMtag PF10159.9 OPL20662.1 - 3.4 8.0 7.3 34 4.8 7.3 2.1 1 1 0 1 1 1 0 Multiple myeloma tumor-associated Cadherin_C_2 PF16492.5 OPL20663.1 - 0.0037 18.0 0.9 0.013 16.2 0.0 2.0 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal CcmD PF04995.14 OPL20663.1 - 0.0085 16.2 0.4 0.013 15.5 0.4 1.3 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) PRIMA1 PF16101.5 OPL20663.1 - 0.02 14.9 0.1 0.032 14.3 0.1 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Rax2 PF12768.7 OPL20663.1 - 0.033 13.6 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity TUDOR PF00567.24 OPL20664.1 - 5.5e-20 71.6 0.0 9.7e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.29 OPL20664.1 - 9e-17 60.7 0.3 1.8e-16 59.7 0.3 1.5 1 0 0 1 1 1 1 KH domain RNase_PH_C PF03725.15 OPL20664.1 - 0.039 14.0 0.1 0.068 13.2 0.1 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 KH_4 PF13083.6 OPL20664.1 - 0.18 11.7 1.5 0.38 10.6 0.2 2.2 3 0 0 3 3 3 0 KH domain Rtf2 PF04641.12 OPL20664.1 - 0.19 11.0 3.9 0.26 10.6 3.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger VWA_2 PF13519.6 OPL20665.1 - 1.6e-05 25.5 0.0 2e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 OPL20665.1 - 0.0001 22.6 0.0 0.00012 22.3 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Methyltrn_RNA_4 PF09936.9 OPL20665.1 - 0.003 17.5 0.0 0.0036 17.2 0.0 1.1 1 0 0 1 1 1 1 SAM-dependent RNA methyltransferase Clat_adaptor_s PF01217.20 OPL20667.1 - 2e-62 209.3 7.7 2.1e-62 209.2 7.7 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain UPF0047 PF01894.17 OPL20668.1 - 0.011 15.8 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0047 C1q PF00386.21 OPL20671.1 - 2.8e-17 63.1 0.2 4e-17 62.6 0.2 1.2 1 0 0 1 1 1 1 C1q domain Aft1_HRA PF11786.8 OPL20671.1 - 0.053 13.9 0.1 0.073 13.4 0.1 1.2 1 0 0 1 1 1 0 Aft1 HRA domain BclA_C PF18573.1 OPL20671.1 - 0.059 13.3 0.6 0.084 12.8 0.6 1.2 1 0 0 1 1 1 0 BclA C-terminal domain Tcell_CD4_C PF12104.8 OPL20671.1 - 0.26 11.3 1.4 3.8 7.5 0.5 2.5 2 0 0 2 2 2 0 T cell CD4 receptor C terminal region C1q PF00386.21 OPL20672.1 - 1.4e-14 54.4 0.6 1.6e-14 54.2 0.6 1.1 1 0 0 1 1 1 1 C1q domain SapB_2 PF03489.17 OPL20672.1 - 0.048 13.8 0.1 2 8.6 0.1 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 2 Fer4_20 PF14691.6 OPL20672.1 - 0.093 12.5 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pkinase PF00069.25 OPL20673.1 - 0.0014 18.0 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Lectin_C PF00059.21 OPL20674.1 - 0.00019 22.1 0.2 0.00035 21.3 0.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain DUF4468 PF14730.6 OPL20676.1 - 0.11 12.8 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold Acp26Ab PF05777.12 OPL20679.1 - 0.15 12.7 0.1 0.95 10.1 0.1 2.0 1 1 1 2 2 2 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) TPR_12 PF13424.6 OPL20680.1 - 4.9e-24 84.4 2.0 7.8e-17 61.3 0.4 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 OPL20680.1 - 2.5e-16 59.0 2.4 1.6e-07 30.9 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 OPL20680.1 - 1.5e-11 43.6 2.4 4.7e-05 23.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 OPL20680.1 - 3.7e-10 39.1 2.4 0.0067 16.4 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_MalT PF17874.1 OPL20680.1 - 7.8e-09 35.3 0.6 1.2e-08 34.8 0.6 1.2 1 0 0 1 1 1 1 MalT-like TPR region TPR_1 PF00515.28 OPL20680.1 - 1.4e-08 34.2 10.2 0.00071 19.3 0.3 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 OPL20680.1 - 2.8e-06 27.0 8.9 0.023 14.8 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 OPL20680.1 - 5.7e-05 23.6 3.3 0.068 14.0 0.0 3.4 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 OPL20680.1 - 0.0021 17.7 2.0 0.028 14.1 0.0 2.7 3 0 0 3 3 3 1 TPR repeat SHNi-TPR PF10516.9 OPL20680.1 - 0.0079 15.6 3.4 0.055 12.9 0.5 3.4 3 1 0 3 3 3 1 SHNi-TPR SNAP PF14938.6 OPL20680.1 - 0.029 13.8 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP DUF1910 PF08928.10 OPL20680.1 - 0.077 13.0 0.3 0.49 10.4 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1910) TPR_17 PF13431.6 OPL20680.1 - 0.23 11.9 1.5 25 5.6 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 OPL20680.1 - 0.65 10.8 3.9 2.1 9.2 0.9 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 OPL20680.1 - 1 9.9 6.9 21 5.7 2.9 2.5 1 1 0 2 2 2 0 Tetratricopeptide repeat Hist_deacetyl PF00850.19 OPL20681.1 - 3.3e-12 46.5 0.0 3.8e-12 46.3 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Choline_kin_N PF04428.14 OPL20682.1 - 0.075 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Choline kinase N terminus AA_permease_2 PF13520.6 OPL20683.1 - 1.1e-11 44.3 21.3 3.3e-06 26.2 9.3 2.3 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 OPL20683.1 - 2e-06 26.7 16.7 0.00076 18.2 7.7 2.1 1 1 1 2 2 2 2 Amino acid permease DOCK-C2 PF14429.6 OPL20684.1 - 2.1e-22 79.9 0.1 2.5e-22 79.7 0.1 1.1 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins PGM_PMM_II PF02879.16 OPL20685.1 - 2.8e-23 82.5 0.0 4.6e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_I PF02878.16 OPL20685.1 - 6.1e-20 71.3 0.1 1.1e-19 70.6 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I DUF2542 PF10808.8 OPL20685.1 - 0.076 13.5 0.6 0.15 12.6 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2542) MIT_LIKE_ACTX PF17556.2 OPL20686.1 - 0.11 13.1 1.1 0.16 12.6 0.1 1.8 2 0 0 2 2 2 0 MIT-like atracotoxin family DUF1974 PF09317.11 OPL20686.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) UBX PF00789.20 OPL20688.1 - 1.5e-11 44.3 0.0 3.2e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 UBX domain Methyltransf_FA PF12248.8 OPL20689.1 - 3.5e-23 81.9 0.8 7.8e-23 80.7 0.2 1.9 2 0 0 2 2 2 1 Farnesoic acid 0-methyl transferase TMEM154 PF15102.6 OPL20689.1 - 0.03 14.2 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Fig1 PF12351.8 OPL20689.1 - 0.093 12.6 0.0 8.6 6.2 0.0 2.4 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Ras PF00071.22 OPL20690.1 - 2.1e-21 76.2 0.2 2.2e-21 76.1 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL20690.1 - 7.8e-16 58.4 0.2 1.1e-15 57.9 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 OPL20690.1 - 1e-07 31.6 0.3 1.2e-07 31.4 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 OPL20690.1 - 0.016 14.5 0.1 0.016 14.5 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PNISR PF15996.5 OPL20692.1 - 0.028 14.7 1.3 0.099 12.9 0.2 1.9 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DNA_pol_phi PF04931.13 OPL20692.1 - 3.7 5.5 7.4 5.1 5.1 7.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi An_peroxidase PF03098.15 OPL20693.1 - 1.1e-68 232.1 0.1 1.3e-68 231.9 0.1 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Med13_C PF06333.12 OPL20694.1 - 1.6e-43 149.2 0.1 3.3e-42 144.9 0.0 2.0 2 0 0 2 2 2 2 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 OPL20694.1 - 1.3e-28 100.4 0.1 1.7e-28 100.1 0.1 1.1 1 0 0 1 1 1 1 MID domain of medPIWI Ion_trans PF00520.31 OPL20696.1 - 0.0005 19.4 0.0 0.00079 18.7 0.0 1.4 1 0 0 1 1 1 1 Ion transport protein DUF3382 PF11862.8 OPL20696.1 - 0.0082 16.4 0.0 0.011 16.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3382) TcpE PF12648.7 OPL20696.1 - 0.044 14.3 1.1 0.1 13.1 1.1 1.8 1 1 0 1 1 1 0 TcpE family C2 PF00168.30 OPL20697.1 - 9.3e-11 41.9 0.1 6.9e-09 35.9 0.0 2.3 2 1 0 2 2 2 2 C2 domain Ank_5 PF13857.6 OPL20698.1 - 2.1e-14 53.4 0.0 2.2e-06 27.8 0.0 2.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL20698.1 - 1.3e-09 38.5 0.0 0.0016 19.0 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL20698.1 - 3.3e-07 30.7 0.1 0.016 15.8 0.0 3.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL20698.1 - 6e-07 29.3 0.1 0.077 13.6 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 OPL20698.1 - 1.8e-05 24.9 0.1 1.8 9.2 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat UBA PF00627.31 OPL20699.1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 UBA/TS-N domain Glyco_hydro_59 PF02057.15 OPL20700.1 - 5e-43 147.4 0.2 6.2e-43 147.1 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30 PF02055.16 OPL20700.1 - 0.016 14.2 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 TIM-barrel domain DUF2441 PF10386.9 OPL20700.1 - 0.053 13.5 0.0 0.061 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2441) Sulfotransfer_1 PF00685.27 OPL20701.1 - 8.8e-24 84.4 0.2 9.1e-23 81.1 0.2 1.9 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_2 PF03567.14 OPL20701.1 - 0.0025 17.7 0.0 0.0033 17.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family CUB PF00431.20 OPL20702.1 - 4.4e-28 97.8 0.1 5.2e-28 97.6 0.1 1.1 1 0 0 1 1 1 1 CUB domain LSM PF01423.22 OPL20703.1 - 2.3e-19 68.8 0.2 2.8e-19 68.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain vATP-synt_E PF01991.18 OPL20703.1 - 0.035 13.5 0.0 0.035 13.5 0.0 1.1 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DUF150_C PF17384.2 OPL20703.1 - 0.036 14.2 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain Glutaredoxin PF00462.24 OPL20703.1 - 0.13 12.5 0.1 0.2 11.9 0.1 1.3 1 0 0 1 1 1 0 Glutaredoxin Peptidase_C1 PF00112.23 OPL20705.1 - 1.3e-70 237.9 2.7 1.6e-70 237.6 2.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 OPL20705.1 - 0.013 14.3 1.7 0.26 10.0 0.5 2.2 2 0 0 2 2 2 0 Peptidase C1-like family DUF4993 PF16384.5 OPL20705.1 - 0.039 13.0 0.4 0.23 10.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function Inhibitor_I29 PF08246.12 OPL20705.1 - 0.042 14.3 0.0 0.077 13.4 0.0 1.4 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) TIR_2 PF13676.6 OPL20706.1 - 5e-14 52.9 0.0 1.2e-13 51.7 0.0 1.7 1 0 0 1 1 1 1 TIR domain Arm PF00514.23 OPL20706.1 - 2.7e-05 24.0 0.0 0.00045 20.2 0.0 3.0 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 OPL20706.1 - 0.094 13.1 0.0 0.97 9.9 0.0 2.5 2 1 1 3 3 3 0 HEAT repeats DUF892 PF05974.12 OPL20706.1 - 0.2 11.7 3.0 1.4 9.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF892) DrsE_2 PF13686.6 OPL20706.1 - 0.22 11.4 2.9 1.7 8.5 0.2 2.7 2 1 0 2 2 2 0 DsrE/DsrF/DrsH-like family Cnd1 PF12717.7 OPL20706.1 - 1.1 9.3 8.5 3.5 7.6 0.2 3.7 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DZR PF12773.7 OPL20707.1 - 0.041 13.9 0.4 0.086 12.9 0.4 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 OPL20707.1 - 0.049 13.0 0.8 0.11 11.9 0.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 OPL20707.1 - 0.27 11.0 0.8 0.59 9.9 0.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain LMBR1 PF04791.16 OPL20707.1 - 7.7 5.3 5.3 11 4.8 5.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Fer2 PF00111.27 OPL20708.1 - 1.7e-10 40.7 0.1 2.2e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain CRAL_TRIO PF00650.20 OPL20709.1 - 3.8e-20 72.2 0.1 4.9e-20 71.9 0.1 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 OPL20709.1 - 0.0012 19.0 0.0 0.0015 18.7 0.0 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain FOXO_KIX_bdg PF16675.5 OPL20709.1 - 0.053 13.8 0.0 7.8 6.9 0.0 2.1 2 0 0 2 2 2 0 KIX-binding domain of forkhead box O, CR2 Retrotran_gag_3 PF14244.6 OPL20709.1 - 0.11 12.3 0.1 0.32 10.8 0.0 1.7 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type PLDc_2 PF13091.6 OPL20710.1 - 6.6e-08 32.5 0.1 1.1e-07 31.9 0.1 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.22 OPL20710.1 - 3e-06 27.2 0.6 5.6e-06 26.3 0.6 1.4 1 0 0 1 1 1 1 Phospholipase D Active site motif Pribosyl_synth PF14572.6 OPL20711.1 - 8.9e-21 74.7 3.2 3.2e-14 53.4 1.0 2.0 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Acyl-CoA_dh_M PF02770.19 OPL20712.1 - 3e-22 78.6 0.0 3.8e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 OPL20712.1 - 0.02 15.6 0.0 0.037 14.7 0.0 1.5 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain DUF2807 PF10988.8 OPL20712.1 - 0.11 12.3 0.1 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Putative auto-transporter adhesin, head GIN domain Kelch_1 PF01344.25 OPL20713.1 - 1.1e-35 121.0 14.3 9.1e-12 44.4 0.2 4.3 4 0 0 4 4 4 4 Kelch motif BACK PF07707.15 OPL20713.1 - 2.7e-32 110.9 4.1 7.9e-32 109.4 2.1 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 OPL20713.1 - 4.6e-20 71.2 5.6 4.7e-06 26.7 0.1 4.4 2 1 2 4 4 4 4 Kelch motif BTB PF00651.31 OPL20713.1 - 2.7e-08 34.0 0.7 2.1e-07 31.1 0.1 2.4 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.6 OPL20713.1 - 2.6e-07 30.8 4.5 0.00046 20.4 0.1 3.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 OPL20713.1 - 5.8e-07 29.4 11.8 0.043 13.8 0.0 4.1 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 OPL20713.1 - 1.5e-05 24.8 11.2 0.01 15.8 0.1 4.9 5 1 0 5 5 5 2 Kelch motif DUF4735 PF15882.5 OPL20714.1 - 1.4e-35 123.2 0.4 1.6e-35 123.0 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4735) TMEM154 PF15102.6 OPL20715.1 - 3.4e-05 23.8 0.3 6.5e-05 22.9 0.2 1.5 1 1 1 2 2 2 1 TMEM154 protein family DUF2207 PF09972.9 OPL20715.1 - 0.0013 17.6 0.0 0.0013 17.6 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Mid2 PF04478.12 OPL20715.1 - 0.0054 16.6 0.6 0.0092 15.8 0.2 1.6 1 1 0 1 1 1 1 Mid2 like cell wall stress sensor Podoplanin PF05808.11 OPL20715.1 - 0.01 16.0 2.2 0.027 14.6 0.3 2.0 1 1 1 2 2 2 0 Podoplanin Rax2 PF12768.7 OPL20715.1 - 0.017 14.6 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Amnionless PF14828.6 OPL20715.1 - 0.019 13.8 0.0 0.021 13.7 0.0 1.1 1 0 0 1 1 1 0 Amnionless TraL PF07178.11 OPL20715.1 - 0.027 14.9 0.1 0.043 14.3 0.1 1.2 1 0 0 1 1 1 0 TraL protein Orf78 PF06024.12 OPL20715.1 - 0.029 14.7 0.1 0.067 13.5 0.0 1.6 1 1 1 2 2 2 0 Orf78 (ac78) EphA2_TM PF14575.6 OPL20715.1 - 0.03 15.2 0.0 0.045 14.6 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Chordopox_A13L PF05961.11 OPL20715.1 - 0.05 13.8 1.2 0.37 11.1 0.1 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein ECSCR PF15820.5 OPL20715.1 - 0.065 13.1 0.1 0.089 12.6 0.1 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator TMEM132D_C PF15706.5 OPL20715.1 - 0.095 12.5 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term BatA PF07584.11 OPL20715.1 - 0.1 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal Neurensin PF14927.6 OPL20715.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Neurensin SIT PF15330.6 OPL20715.1 - 0.16 12.4 1.3 0.16 12.4 0.2 1.7 2 1 0 2 2 1 0 SHP2-interacting transmembrane adaptor protein, SIT Calcyon PF06387.11 OPL20715.1 - 1.4 8.8 4.4 3.2 7.7 0.7 2.0 1 1 1 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) SKG6 PF08693.10 OPL20715.1 - 1.6 8.2 8.9 0.83 9.1 3.9 2.2 1 1 1 2 2 2 0 Transmembrane alpha-helix domain Orthoreo_P10 PF07204.11 OPL20716.1 - 0.0069 16.3 0.1 0.012 15.5 0.1 1.4 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 FAM176 PF14851.6 OPL20716.1 - 0.018 14.7 0.1 0.047 13.3 0.0 1.8 2 0 0 2 2 2 0 FAM176 family EphA2_TM PF14575.6 OPL20716.1 - 0.044 14.7 0.0 0.081 13.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SKA2 PF16740.5 OPL20717.1 - 0.00051 19.8 4.0 0.00081 19.2 4.0 1.3 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 YabA PF06156.13 OPL20717.1 - 0.0012 19.5 7.6 0.16 12.6 0.8 2.2 1 1 1 2 2 2 2 Initiation control protein YabA Med9 PF07544.13 OPL20717.1 - 0.011 15.8 5.4 0.052 13.6 3.5 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF1664 PF07889.12 OPL20717.1 - 0.017 15.1 5.6 0.099 12.7 5.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) HEPN_RiboL-PSP PF18735.1 OPL20717.1 - 0.018 15.0 1.4 0.023 14.6 1.4 1.2 1 0 0 1 1 1 0 RiboL-PSP-HEPN DUF3450 PF11932.8 OPL20717.1 - 0.022 14.0 6.6 0.034 13.5 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Laminin_II PF06009.12 OPL20717.1 - 0.029 14.4 6.3 0.033 14.2 4.2 1.8 1 1 1 2 2 2 0 Laminin Domain II Baculo_PEP_C PF04513.12 OPL20717.1 - 0.042 13.9 0.8 0.065 13.3 0.8 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.19 OPL20717.1 - 0.042 11.8 3.2 0.048 11.6 3.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CortBP2 PF09727.9 OPL20717.1 - 0.047 13.6 7.1 0.062 13.2 7.1 1.1 1 0 0 1 1 1 0 Cortactin-binding protein-2 Snapin_Pallidin PF14712.6 OPL20717.1 - 0.052 14.0 0.3 0.052 14.0 0.3 2.7 2 1 1 3 3 3 0 Snapin/Pallidin DUF489 PF04356.12 OPL20717.1 - 0.057 13.4 2.1 0.076 13.0 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) FAM184 PF15665.5 OPL20717.1 - 0.066 13.0 9.4 0.093 12.5 9.4 1.3 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B APG6_N PF17675.1 OPL20717.1 - 0.083 13.4 9.1 0.19 12.3 8.7 1.7 1 1 1 2 2 2 0 Apg6 coiled-coil region Cluap1 PF10234.9 OPL20717.1 - 0.14 11.5 6.3 0.22 10.9 6.3 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 KRAP_IP3R_bind PF14722.6 OPL20717.1 - 0.22 11.2 4.8 0.88 9.3 0.3 2.2 1 1 1 2 2 2 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain FapA PF03961.13 OPL20717.1 - 0.37 9.3 7.1 0.46 9.0 7.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF948 PF06103.11 OPL20717.1 - 0.49 10.7 2.6 1.4 9.2 2.6 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Tup_N PF08581.10 OPL20717.1 - 0.97 9.8 10.5 4.1 7.8 0.6 2.5 1 1 1 2 2 2 0 Tup N-terminal Prominin PF05478.11 OPL20717.1 - 2 6.2 6.0 2.3 6.1 6.0 1.1 1 0 0 1 1 1 0 Prominin LPP PF04728.13 OPL20717.1 - 2.2 8.8 5.4 1.3 9.5 0.8 2.7 2 1 1 3 3 3 0 Lipoprotein leucine-zipper AAA_7 PF12775.7 OPL20719.1 - 6.1e-28 97.6 0.1 8.9e-28 97.0 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_1 PF17857.1 OPL20719.1 - 8.3e-17 61.2 0.0 1.9e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain VEFS-Box PF09733.9 OPL20719.1 - 0.3 10.9 4.7 0.66 9.8 2.1 2.4 2 1 1 3 3 3 0 VEFS-Box of polycomb protein Thioredoxin PF00085.20 OPL20720.1 - 2.3e-46 156.0 1.1 2.1e-23 82.3 0.2 2.7 3 0 0 3 3 3 2 Thioredoxin OST3_OST6 PF04756.13 OPL20720.1 - 1.7e-09 37.5 0.1 1.9e-05 24.2 0.1 2.4 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 OPL20720.1 - 1.5e-08 35.0 0.6 0.0065 16.9 0.2 2.9 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 OPL20720.1 - 2.3e-05 24.6 0.3 0.18 12.2 0.1 3.8 2 2 2 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.6 OPL20720.1 - 2.4e-05 24.5 0.8 0.095 12.9 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.6 OPL20720.1 - 0.0013 18.5 2.6 0.089 12.6 0.0 2.7 2 1 1 3 3 3 2 Thioredoxin AhpC-TSA PF00578.21 OPL20720.1 - 0.0036 17.2 1.3 0.8 9.6 0.1 2.3 2 0 0 2 2 2 2 AhpC/TSA family DUF1563 PF07599.11 OPL20720.1 - 0.02 15.0 2.9 1.3 9.2 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1563) Redoxin PF08534.10 OPL20720.1 - 0.076 12.7 0.4 0.37 10.5 0.0 2.0 2 0 0 2 2 2 0 Redoxin CARD_2 PF16739.5 OPL20721.1 - 7.3e-13 48.3 0.0 1.1e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Caspase recruitment domain CARD PF00619.21 OPL20721.1 - 8.2e-07 29.0 0.0 1.4e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Caspase recruitment domain CARD PF00619.21 OPL20723.1 - 1.1e-16 60.6 2.2 9.3e-10 38.4 0.2 2.6 2 1 0 2 2 2 2 Caspase recruitment domain Death PF00531.22 OPL20723.1 - 2.5e-12 46.8 0.6 4.1e-11 42.9 0.0 2.2 2 0 0 2 2 2 1 Death domain CARD_2 PF16739.5 OPL20723.1 - 4.7e-09 36.1 0.4 0.0047 16.9 0.0 2.7 2 1 1 3 3 3 2 Caspase recruitment domain F5_F8_type_C PF00754.25 OPL20724.1 - 0.00016 21.8 0.1 0.00043 20.4 0.0 1.7 1 1 1 2 2 2 1 F5/8 type C domain GpcrRhopsn4 PF10192.9 OPL20725.1 - 7.5e-22 78.0 6.6 8.7e-22 77.8 6.6 1.1 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain GUB_WAK_bind PF13947.6 OPL20726.1 - 0.021 15.6 0.0 0.026 15.3 0.0 1.2 1 0 0 1 1 1 0 Wall-associated receptor kinase galacturonan-binding RNB PF00773.19 OPL20727.1 - 2.9e-35 122.1 0.1 3.7e-35 121.8 0.1 1.1 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 OPL20727.1 - 1.4e-23 82.7 0.0 2.9e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 OPL20727.1 - 1.3e-06 28.5 0.1 2.4e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 Cold shock domain DUF1889 PF08986.10 OPL20728.1 - 0.092 13.2 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1889) Med3 PF11593.8 OPL20729.1 - 0.012 14.9 1.6 0.013 14.7 1.6 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PPP1R35_C PF15503.6 OPL20729.1 - 0.021 14.6 0.5 0.034 14.0 0.5 1.3 1 1 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus Herpes_DNAp_acc PF04929.12 OPL20729.1 - 0.039 12.9 0.8 0.043 12.8 0.8 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor FAM24 PF15193.6 OPL20729.1 - 0.058 14.2 0.1 0.084 13.7 0.1 1.3 1 1 0 1 1 1 0 FAM24 family TMEM154 PF15102.6 OPL20729.1 - 0.064 13.2 3.4 0.053 13.4 0.9 1.9 1 1 1 2 2 2 0 TMEM154 protein family EphA2_TM PF14575.6 OPL20729.1 - 0.28 12.1 3.1 0.76 10.7 3.1 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Kinesin PF00225.23 OPL20730.1 - 1.7e-37 129.1 0.1 2e-37 128.9 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 OPL20730.1 - 1.9e-24 86.3 0.1 2.1e-24 86.1 0.1 1.0 1 0 0 1 1 1 1 Microtubule binding AAA_33 PF13671.6 OPL20730.1 - 0.11 12.7 0.0 0.26 11.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 OPL20732.1 - 5.2e-11 42.8 0.0 7.8e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 OPL20732.1 - 6.4e-06 26.0 0.0 1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 OPL20732.1 - 4.2e-05 23.9 0.0 6.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 OPL20732.1 - 0.0014 18.6 0.0 0.0024 17.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 OPL20732.1 - 0.011 14.8 0.0 0.015 14.4 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 OPL20732.1 - 0.015 15.8 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 OPL20732.1 - 0.021 15.2 0.0 0.049 14.0 0.0 1.6 1 1 1 2 2 2 0 AAA ATPase domain UvrD-helicase PF00580.21 OPL20732.1 - 0.023 14.2 0.0 0.035 13.6 0.0 1.3 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 OPL20732.1 - 0.041 14.2 0.0 0.086 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 OPL20732.1 - 0.056 13.0 0.0 0.077 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 OPL20732.1 - 0.06 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 OPL20732.1 - 0.062 13.3 0.0 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 OPL20732.1 - 0.15 12.4 0.0 1.9 8.9 0.0 2.1 2 0 0 2 2 2 0 RNA helicase PhoH PF02562.16 OPL20732.1 - 0.18 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein CTC1 PF15489.6 OPL20733.1 - 2.6e-22 78.3 4.2 3.2e-22 78.0 4.2 1.0 1 0 0 1 1 1 1 CST, telomere maintenance, complex subunit CTC1 Ig_3 PF13927.6 OPL20735.1 - 3.6e-09 37.1 1.2 0.0014 19.1 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL20735.1 - 2.4e-08 34.0 3.0 9.7e-05 22.5 0.1 2.4 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL20735.1 - 2.8e-06 27.3 0.4 0.054 13.6 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL20735.1 - 0.00064 20.0 1.8 0.65 10.4 0.1 2.5 1 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 OPL20735.1 - 0.0091 16.2 6.8 0.079 13.1 1.2 3.3 2 2 0 2 2 2 1 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.11 OPL20735.1 - 0.038 14.0 0.8 0.08 12.9 0.0 2.0 2 1 0 2 2 2 0 Ig-like C2-type domain Ig_6 PF18452.1 OPL20735.1 - 0.047 13.3 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Fibrinogen_C PF00147.18 OPL20736.1 - 3.1e-33 115.4 5.6 3.5e-33 115.3 5.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ribosomal_60s PF00428.19 OPL20737.1 - 1.3e-07 32.1 0.0 1.5e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein RRM_1 PF00076.22 OPL20738.1 - 0.0061 16.3 0.3 0.021 14.6 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TIG PF01833.24 OPL20739.1 - 1.2e-10 41.3 4.0 1.2e-10 41.3 4.0 1.9 2 0 0 2 2 2 1 IPT/TIG domain PSI PF01437.25 OPL20739.1 - 1.1e-05 25.8 17.9 2e-05 25.0 17.9 1.4 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.3 OPL20739.1 - 0.13 12.0 14.1 0.26 11.0 14.1 1.5 1 0 0 1 1 1 0 Integrin plexin domain Na_Ca_ex PF01699.24 OPL20739.1 - 0.18 11.7 1.1 1 9.3 0.1 2.1 2 0 0 2 2 2 0 Sodium/calcium exchanger protein RA PF00788.23 OPL20740.1 - 9e-22 77.5 0.1 3.5e-12 46.8 0.0 2.4 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain Ribosomal_L44 PF00935.19 OPL20741.1 - 1.5e-05 25.4 2.9 1.5e-05 25.4 2.9 1.4 2 0 0 2 2 2 1 Ribosomal protein L44 CARDB PF07705.11 OPL20743.1 - 0.026 14.8 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 CARDB Y_phosphatase PF00102.27 OPL20744.1 - 0.00014 21.5 0.9 0.00027 20.6 0.1 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DTC PF18102.1 OPL20745.1 - 2.3e-51 173.4 0.0 3.5e-51 172.8 0.0 1.3 1 0 0 1 1 1 1 Deltex C-terminal domain zf-C3HC4_2 PF13923.6 OPL20745.1 - 1.7e-08 34.1 14.2 2.9e-08 33.4 14.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL20745.1 - 7.7e-08 32.6 12.5 1.4e-07 31.7 12.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 OPL20745.1 - 1.6e-06 27.9 14.0 3.1e-06 26.9 14.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 OPL20745.1 - 3.7e-06 26.8 8.0 3.7e-06 26.8 8.0 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 OPL20745.1 - 9.1e-06 25.4 9.4 1.5e-05 24.7 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 OPL20745.1 - 1.3e-05 25.0 12.6 2.4e-05 24.2 12.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 OPL20745.1 - 3.2e-05 24.1 7.7 7.1e-05 23.0 7.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 OPL20745.1 - 0.00081 19.5 6.1 0.0015 18.6 6.1 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-Nse PF11789.8 OPL20745.1 - 0.0016 18.3 8.7 0.0035 17.1 8.7 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit FMN_bind_2 PF04299.12 OPL20745.1 - 0.0021 17.8 0.1 0.0039 16.9 0.1 1.4 1 0 0 1 1 1 1 Putative FMN-binding domain zf-C3HC4_4 PF15227.6 OPL20745.1 - 0.0037 17.4 13.6 0.0078 16.3 13.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 OPL20745.1 - 0.0056 16.5 10.8 0.011 15.6 10.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 OPL20745.1 - 0.014 15.2 8.4 0.03 14.2 8.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 OPL20745.1 - 0.017 14.8 8.5 0.038 13.7 8.5 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-MIZ PF02891.20 OPL20745.1 - 3.7 7.4 12.7 12 5.7 12.7 1.9 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Keratin_2_head PF16208.5 OPL20746.1 - 9.8 6.3 42.5 3.3 7.8 20.1 2.2 2 0 0 2 2 2 0 Keratin type II head Reprolysin PF01421.19 OPL20748.1 - 1.9e-12 47.5 0.1 2.4e-12 47.2 0.1 1.1 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.6 OPL20748.1 - 1.6e-08 35.1 0.4 1e-07 32.5 0.1 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 OPL20748.1 - 7.9e-07 29.4 0.6 9.2e-07 29.2 0.6 1.1 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 OPL20748.1 - 6.3e-06 26.0 0.2 6.8e-06 25.9 0.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 OPL20748.1 - 0.0001 22.3 0.5 0.0002 21.4 0.6 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 OPL20748.1 - 0.0047 16.8 0.0 0.0062 16.4 0.0 1.1 1 0 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.9 OPL20748.1 - 0.036 13.0 1.4 0.055 12.4 1.4 1.3 1 1 0 1 1 1 0 Peptidase M66 Astacin PF01400.24 OPL20748.1 - 0.052 13.1 0.0 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Metallopep PF12044.8 OPL20748.1 - 0.073 11.7 0.3 0.07 11.7 0.3 1.1 1 0 0 1 1 1 0 Putative peptidase family MFS_1 PF07690.16 OPL20749.1 - 0.01 14.8 7.4 0.011 14.7 7.4 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily Vinculin PF01044.19 OPL20750.1 - 3.3e-113 379.9 9.1 4e-113 379.6 9.1 1.0 1 0 0 1 1 1 1 Vinculin family AAA_32 PF13654.6 OPL20750.1 - 0.017 13.9 0.9 0.12 11.2 0.0 2.0 1 1 1 2 2 2 0 AAA domain PspA_IM30 PF04012.12 OPL20750.1 - 0.098 12.2 5.4 0.58 9.7 5.5 1.9 1 1 0 1 1 1 0 PspA/IM30 family NO_synthase PF02898.15 OPL20752.1 - 6.4e-97 324.8 0.0 7.1e-97 324.7 0.0 1.0 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain COX15-CtaA PF02628.15 OPL20753.1 - 1.2e-11 44.3 1.8 1.4e-11 44.1 1.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein MAP70 PF07058.11 OPL20754.1 - 1.5 7.4 8.8 1.9 7.1 8.8 1.0 1 0 0 1 1 1 0 Microtubule-associated protein 70 KxDL PF10241.9 OPL20757.1 - 3.4e-16 59.3 0.4 7.9e-16 58.1 0.4 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein Med8 PF10232.9 OPL20757.1 - 0.038 13.6 3.2 0.6 9.7 0.8 2.2 1 1 1 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 DUF4710 PF15828.5 OPL20757.1 - 0.043 13.9 1.3 0.06 13.5 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) DUF1043 PF06295.12 OPL20757.1 - 0.047 13.7 1.4 0.08 12.9 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) FAM220 PF15487.6 OPL20757.1 - 0.12 11.9 6.3 0.17 11.5 6.3 1.2 1 0 0 1 1 1 0 FAM220 family YabA PF06156.13 OPL20757.1 - 0.37 11.5 0.1 0.37 11.5 0.1 2.8 2 1 0 2 2 2 0 Initiation control protein YabA Lipocalin_7 PF14651.6 OPL20758.1 - 0.0087 16.0 0.7 0.013 15.4 0.7 1.4 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF1942 PF09167.11 OPL20758.1 - 0.0098 15.8 0.1 0.012 15.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1942) Lipocalin PF00061.23 OPL20758.1 - 0.04 14.1 2.7 0.052 13.8 2.7 1.3 1 1 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family DUF5011 PF16403.5 OPL20758.1 - 0.084 13.0 0.8 0.89 9.7 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) MRP_L53 PF10780.9 OPL20759.1 - 0.00076 19.6 0.4 0.0017 18.5 0.1 1.7 2 0 0 2 2 2 1 39S ribosomal protein L53/MRP-L53 Aa_trans PF01490.18 OPL20760.1 - 8.2e-16 57.7 6.7 8.4e-16 57.7 6.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2207 PF09972.9 OPL20760.1 - 0.69 8.6 3.2 0.75 8.5 3.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Vma12 PF11712.8 OPL20761.1 - 3.4e-19 69.3 0.0 4e-19 69.1 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Phage_holin_2_1 PF04971.12 OPL20761.1 - 0.12 12.4 0.2 0.19 11.7 0.1 1.6 1 1 0 1 1 1 0 Bacteriophage P21 holin S DUF4407 PF14362.6 OPL20761.1 - 0.2 11.0 1.1 0.22 10.8 0.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Glu_synthase PF01645.17 OPL20762.1 - 3.4e-62 210.7 0.1 5.1e-62 210.1 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase GXGXG PF01493.19 OPL20762.1 - 3.8e-19 69.0 0.1 5.7e-19 68.5 0.1 1.3 1 0 0 1 1 1 1 GXGXG motif FMN_dh PF01070.18 OPL20762.1 - 0.0005 19.2 0.1 0.0012 18.0 0.1 1.6 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Vir_act_alpha_C PF10400.9 OPL20763.1 - 0.15 12.7 3.8 0.71 10.6 0.4 2.3 1 1 1 2 2 2 0 Virulence activator alpha C-term OmpH PF03938.14 OPL20763.1 - 0.46 10.8 6.3 0.68 10.3 6.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ubiquitin PF00240.23 OPL20764.1 - 7.6e-10 38.4 0.6 2.2e-09 36.9 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 OPL20764.1 - 0.012 15.4 0.1 0.039 13.8 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like DUF5066 PF16728.5 OPL20764.1 - 0.019 14.3 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5066) C1q PF00386.21 OPL20766.1 - 3.1e-17 63.0 0.4 3.1e-17 63.0 0.4 1.5 2 0 0 2 2 2 1 C1q domain Shugoshin_N PF07558.11 OPL20766.1 - 0.0033 17.3 0.9 0.0064 16.3 0.4 1.7 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region JIP_LZII PF16471.5 OPL20766.1 - 0.08 13.1 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II I-set PF07679.16 OPL20767.1 - 7.3e-07 29.2 1.4 1.4e-06 28.3 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL20767.1 - 1.2e-05 25.8 0.7 3.1e-05 24.5 0.7 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL20767.1 - 6e-05 23.3 1.5 0.00013 22.2 1.1 1.7 2 0 0 2 2 2 1 Immunoglobulin domain GAS PF13851.6 OPL20767.1 - 0.00015 21.1 25.3 0.00015 21.1 25.3 2.3 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding DUF489 PF04356.12 OPL20767.1 - 0.016 15.2 3.0 0.016 15.2 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF489) V-set PF07686.17 OPL20767.1 - 0.019 15.2 1.3 1 9.6 1.3 2.8 1 1 0 1 1 1 0 Immunoglobulin V-set domain ig PF00047.25 OPL20767.1 - 0.027 14.7 1.6 0.064 13.4 1.6 1.7 1 0 0 1 1 1 0 Immunoglobulin domain PspB PF06667.12 OPL20767.1 - 0.042 13.9 0.9 0.042 13.9 0.9 2.5 2 1 1 3 3 3 0 Phage shock protein B Ig_6 PF18452.1 OPL20767.1 - 0.052 13.1 0.4 0.16 11.6 0.4 1.9 1 0 0 1 1 1 0 Immunoglobulin domain Spc7 PF08317.11 OPL20767.1 - 1.1 8.0 36.0 0.062 12.2 10.1 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein PEARLI-4 PF05278.12 OPL20767.1 - 1.2 8.6 39.0 0.88 9.1 26.3 3.3 1 1 2 3 3 3 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF390 PF04094.14 OPL20767.1 - 1.3 7.2 8.8 1.5 7.0 8.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Tn7_Tnp_TnsA_C PF08721.11 OPL20767.1 - 2 9.1 8.6 7.6 7.3 0.1 3.4 3 3 1 4 4 3 0 TnsA endonuclease C terminal Fez1 PF06818.15 OPL20767.1 - 2.9 8.3 31.3 8.3 6.8 31.3 1.8 1 1 0 1 1 1 0 Fez1 DUF4200 PF13863.6 OPL20767.1 - 4.8 7.6 46.8 0.29 11.5 30.6 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) UPF0242 PF06785.11 OPL20767.1 - 8.7 6.4 40.7 5.8 7.0 20.7 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Ig_3 PF13927.6 OPL20768.1 - 4.6e-13 49.6 1.7 1.8e-09 38.1 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 OPL20768.1 - 1.6e-12 47.5 2.2 1.3e-06 28.7 0.2 3.2 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL20768.1 - 8.4e-10 38.7 1.9 0.00056 20.0 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL20768.1 - 5.4e-08 32.8 0.3 0.00014 21.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 OPL20768.1 - 0.067 13.4 0.3 1.7 8.9 0.0 2.6 2 2 0 2 2 2 0 Immunoglobulin V-set domain C1-set PF07654.15 OPL20768.1 - 0.08 13.3 0.5 0.28 11.6 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin C1-set domain Big_2 PF02368.18 OPL20768.1 - 0.19 11.6 5.3 17 5.4 0.5 3.5 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 2) Sec7_N PF12783.7 OPL20770.1 - 3.8e-05 23.6 1.4 5.6e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1045 PF06299.12 OPL20770.1 - 0.0013 18.7 0.0 0.015 15.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1045) DUF4045 PF13254.6 OPL20770.1 - 0.0034 17.1 8.6 0.0044 16.7 8.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4045) Plasmodium_Vir PF05795.11 OPL20770.1 - 7.4 5.9 7.2 16 4.7 7.2 1.6 1 1 0 1 1 1 0 Plasmodium vivax Vir protein Ras PF00071.22 OPL20772.1 - 4.3e-13 49.2 0.0 5.1e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL20772.1 - 6.2e-10 39.3 0.0 1e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 OPL20772.1 - 0.0083 15.8 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ABC_tran PF00005.27 OPL20772.1 - 0.021 15.4 0.7 0.08 13.4 0.1 1.9 2 0 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.23 OPL20772.1 - 0.039 14.0 0.2 0.058 13.5 0.1 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase CbiA PF01656.23 OPL20772.1 - 0.056 13.5 1.5 3.1 7.9 1.8 2.2 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain RsgA_GTPase PF03193.16 OPL20772.1 - 0.095 12.6 0.7 0.095 12.6 0.7 1.8 2 0 0 2 2 2 0 RsgA GTPase Phage_TAC_13 PF16459.5 OPL20772.1 - 0.14 12.6 0.0 0.28 11.7 0.0 1.5 1 1 0 1 1 1 0 Phage tail assembly chaperone, TAC Somatomedin_B PF01033.17 OPL20773.1 - 3.3e-05 24.2 11.1 4.1e-05 23.9 11.1 1.2 1 0 0 1 1 1 1 Somatomedin B domain EphA2_TM PF14575.6 OPL20775.1 - 0.0049 17.7 0.2 0.0094 16.8 0.2 1.7 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 OPL20775.1 - 0.018 15.3 1.0 0.034 14.4 0.2 1.8 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Adeno_E3_CR2 PF02439.15 OPL20775.1 - 0.023 14.5 0.2 0.034 13.9 0.2 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Alginate_exp PF13372.6 OPL20775.1 - 0.037 12.8 1.3 0.4 9.4 0.0 2.0 1 1 1 2 2 2 0 Alginate export Cadherin_C_2 PF16492.5 OPL20775.1 - 0.13 13.0 0.1 0.71 10.7 0.0 2.0 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal EF-hand_7 PF13499.6 OPL20776.1 - 1.8e-18 66.7 6.4 5.1e-11 42.9 1.7 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 OPL20776.1 - 1.8e-14 53.3 6.6 1.3e-06 28.2 0.0 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 OPL20776.1 - 5.6e-10 39.4 1.2 0.00036 20.8 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 OPL20776.1 - 3.4e-09 35.9 9.2 1.9e-06 27.3 0.1 4.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 OPL20776.1 - 2.8e-07 29.6 11.9 1.7e-05 24.0 0.2 4.4 4 1 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 OPL20776.1 - 0.00063 19.1 0.6 0.0021 17.5 0.1 2.2 2 0 0 2 2 2 1 EF hand UPF0154 PF03672.13 OPL20776.1 - 0.00083 19.3 0.0 1.8 8.7 0.0 2.7 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 OPL20776.1 - 0.0038 17.3 2.7 0.0045 17.1 1.3 1.9 2 0 0 2 2 2 1 Ca2+ insensitive EF hand DUF3349 PF11829.8 OPL20776.1 - 0.031 15.1 1.0 0.99 10.2 0.3 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3349) EF-hand_11 PF08976.11 OPL20776.1 - 0.051 14.5 0.2 0.14 13.0 0.1 1.7 1 1 1 2 2 2 0 EF-hand domain EF-hand_14 PF17959.1 OPL20776.1 - 0.22 11.9 3.0 0.5 10.7 0.4 2.8 2 2 1 3 3 3 0 EF-hand domain Pex14_N PF04695.13 OPL20776.1 - 5.4 7.7 6.5 3.2 8.4 4.1 1.8 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MAPEG PF01124.18 OPL20777.1 - 1e-07 31.9 2.1 7.2e-07 29.2 1.9 1.9 1 1 0 1 1 1 1 MAPEG family Laminin_G_1 PF00054.23 OPL20778.1 - 2.3e-12 47.3 0.0 4e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 OPL20778.1 - 2.2e-11 44.4 0.0 4.7e-11 43.4 0.0 1.6 2 0 0 2 2 2 1 Laminin G domain Laminin_II PF06009.12 OPL20778.1 - 2.4e-10 40.6 3.2 4.3e-10 39.7 3.2 1.4 1 0 0 1 1 1 1 Laminin Domain II zf-C4H2 PF10146.9 OPL20778.1 - 0.19 12.0 1.3 0.34 11.2 1.2 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein DUF3504 PF12012.8 OPL20779.1 - 8.3e-18 64.8 0.0 1e-17 64.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) Trypsin_2 PF13365.6 OPL20780.1 - 2.7e-10 41.3 0.0 6.7e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 OPL20780.1 - 0.0039 17.0 0.0 0.007 16.2 0.0 1.4 1 0 0 1 1 1 1 Trypsin But2 PF09792.9 OPL20780.1 - 0.16 12.4 1.3 3.8 7.9 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin 3 binding protein But2 C-terminal domain APG9 PF04109.16 OPL20782.1 - 8.4e-53 180.1 1.1 9.3e-53 179.9 1.1 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 NICE-3 PF07406.11 OPL20783.1 - 2.4e-42 145.0 0.0 3.3e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 NICE-3 protein GAS PF13851.6 OPL20784.1 - 0.015 14.6 0.8 0.015 14.6 0.8 1.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1640 PF07798.11 OPL20784.1 - 0.017 15.2 0.4 0.035 14.2 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) COG2 PF06148.11 OPL20784.1 - 0.017 15.2 0.5 0.031 14.4 0.5 1.4 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 OPL20784.1 - 0.032 14.2 0.4 0.13 12.3 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF745 PF05335.13 OPL20784.1 - 0.13 11.9 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) YojJ PF10372.9 OPL20784.1 - 0.47 10.6 5.0 0.52 10.4 0.1 3.1 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus Apyrase PF06079.11 OPL20785.1 - 5.7e-96 321.2 2.4 7.4e-96 320.8 2.4 1.1 1 0 0 1 1 1 1 Apyrase CD20 PF04103.15 OPL20785.1 - 0.045 13.8 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 CD20-like family zf-Di19 PF05605.12 OPL20787.1 - 9.1e-05 22.7 21.0 0.0017 18.6 1.7 3.9 2 1 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 OPL20787.1 - 0.099 13.5 52.7 0.11 13.3 0.2 7.5 7 0 0 7 7 7 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 OPL20787.1 - 0.11 13.0 0.0 0.11 13.0 0.0 7.2 8 0 0 8 8 8 0 Zinc-finger double domain zf-C2H2 PF00096.26 OPL20787.1 - 0.32 11.5 0.2 0.32 11.5 0.2 7.4 7 0 0 7 7 7 0 Zinc finger, C2H2 type Actin_micro PF17003.5 OPL20787.1 - 0.4 9.8 25.8 4.8 6.2 6.8 4.4 2 2 0 2 2 2 0 Putative actin-like family zf-C2H2_6 PF13912.6 OPL20787.1 - 0.48 10.5 0.1 0.3 11.1 0.3 6.7 8 0 0 8 8 8 0 C2H2-type zinc finger Gal-bind_lectin PF00337.22 OPL20788.1 - 5.9e-44 148.8 0.1 3e-22 78.6 0.0 2.5 2 1 1 3 3 3 2 Galactoside-binding lectin COR PF16095.5 OPL20790.1 - 5.7e-14 52.4 1.7 2.6e-13 50.2 0.3 2.2 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain ig PF00047.25 OPL20790.1 - 1.5e-09 37.9 0.3 5.4e-09 36.1 0.2 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 OPL20790.1 - 2.2e-06 28.2 0.2 5.1e-06 27.0 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 OPL20790.1 - 1.6e-05 25.1 0.7 6e-05 23.2 0.7 2.0 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 OPL20790.1 - 0.0015 18.6 0.1 0.0036 17.3 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL20790.1 - 0.1 13.0 0.8 0.43 10.9 0.2 2.4 3 0 0 3 3 3 0 Immunoglobulin domain Ig_6 PF18452.1 OPL20790.1 - 0.12 11.9 2.2 4.2 7.0 0.1 2.7 2 0 0 2 2 2 0 Immunoglobulin domain ZYG-11_interact PF05884.12 OPL20791.1 - 0.48 9.8 5.8 0.73 9.2 5.8 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 IQ PF00612.27 OPL20794.1 - 1.3e-08 33.9 9.1 0.00084 18.9 0.1 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif Sel_put PF04328.13 OPL20794.1 - 0.0046 17.0 0.2 0.013 15.5 0.2 1.7 1 0 0 1 1 1 1 Selenoprotein, putative SSF PF00474.17 OPL20796.1 - 4.1e-31 108.2 4.5 4.1e-31 108.2 4.5 1.7 3 0 0 3 3 3 1 Sodium:solute symporter family DUF2207 PF09972.9 OPL20796.1 - 1.3 7.7 6.2 1.6 7.4 2.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4231 PF14015.6 OPL20796.1 - 5.4 7.5 5.5 3.2 8.3 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) DUF442 PF04273.13 OPL20797.1 - 3.2e-16 59.4 0.0 1.6e-05 25.0 0.0 3.2 3 0 0 3 3 3 3 Putative phosphatase (DUF442) Y_phosphatase3 PF13350.6 OPL20797.1 - 6.7e-05 23.0 0.0 0.038 13.9 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family DSPc PF00782.20 OPL20797.1 - 0.0076 16.1 0.0 9.7 6.0 0.0 3.3 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain TatD_DNase PF01026.21 OPL20797.1 - 0.013 14.9 0.0 0.035 13.5 0.0 1.6 2 0 0 2 2 2 0 TatD related DNase PTPlike_phytase PF14566.6 OPL20797.1 - 0.022 14.9 0.0 0.38 10.8 0.0 2.2 2 0 0 2 2 2 0 Inositol hexakisphosphate Rhodanese PF00581.20 OPL20797.1 - 0.03 14.8 0.7 0.75 10.3 0.4 2.7 2 1 0 2 2 2 0 Rhodanese-like domain DUF1010 PF06231.11 OPL20797.1 - 0.2 12.2 0.0 0.84 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1010) p450 PF00067.22 OPL20798.1 - 7.1e-27 94.3 0.6 7.4e-27 94.2 0.6 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sema PF01403.19 OPL20799.1 - 1.4e-47 162.5 0.0 1.8e-47 162.1 0.0 1.0 1 0 0 1 1 1 1 Sema domain SSF PF00474.17 OPL20800.1 - 1.2e-33 116.6 6.9 1.3e-33 116.5 6.9 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family CDC45 PF02724.14 OPL20801.1 - 0.061 11.6 5.8 0.068 11.5 5.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 OPL20801.1 - 0.43 9.8 2.3 0.51 9.5 2.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Rota_VP2 PF05087.12 OPL20801.1 - 5 5.1 5.0 6.1 4.9 5.0 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein DUF4551 PF15087.6 OPL20801.1 - 6.9 5.4 10.4 7.4 5.3 10.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CUE PF02845.16 OPL20802.1 - 0.0035 17.0 4.9 2.1 8.1 0.1 4.7 5 1 0 5 5 5 2 CUE domain Lip_prot_lig_C PF10437.9 OPL20802.1 - 0.059 13.4 2.7 0.36 10.8 0.1 3.4 3 1 1 4 4 4 0 Bacterial lipoate protein ligase C-terminus YozE_SAM_like PF06855.12 OPL20802.1 - 0.077 13.2 2.1 1.5 9.0 0.1 3.1 3 0 0 3 3 3 0 YozE SAM-like fold PEHE PF15275.6 OPL20802.1 - 0.23 12.1 3.4 0.67 10.6 0.3 2.9 3 0 0 3 3 3 0 PEHE domain Ribosomal_L14 PF00238.19 OPL20803.1 - 8.8e-27 93.6 0.5 1e-26 93.4 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Aldedh PF00171.22 OPL20804.1 - 2.4e-13 49.4 0.0 3.9e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family adh_short PF00106.25 OPL20805.1 - 2.4e-34 118.5 0.0 3.1e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL20805.1 - 9.2e-23 81.0 0.0 1.1e-22 80.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 OPL20805.1 - 2.9e-05 24.1 0.0 4.4e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 KR domain TIG PF01833.24 OPL20807.1 - 3e-15 56.1 2.6 5.2e-08 32.9 0.1 3.6 4 0 0 4 4 4 3 IPT/TIG domain TIG_2 PF18020.1 OPL20807.1 - 2.6e-05 24.7 0.0 8.6e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 TIG domain found in plexin ATG27 PF09451.10 OPL20808.1 - 0.039 13.8 0.6 0.039 13.8 0.6 1.0 1 0 0 1 1 1 0 Autophagy-related protein 27 ESSS PF10183.9 OPL20808.1 - 0.065 13.4 0.2 0.08 13.2 0.2 1.1 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DFF40 PF09230.10 OPL20809.1 - 3.2e-48 164.3 0.2 3.6e-48 164.2 0.2 1.0 1 0 0 1 1 1 1 DNA fragmentation factor 40 kDa DZR PF12773.7 OPL20810.1 - 3.7e-11 42.9 14.0 9.8e-08 31.9 4.1 2.9 2 1 0 2 2 2 2 Double zinc ribbon zinc_ribbon_2 PF13240.6 OPL20810.1 - 3.2e-07 29.8 21.0 0.0031 17.2 1.8 4.3 3 1 1 4 4 4 4 zinc-ribbon domain zf-ribbon_3 PF13248.6 OPL20810.1 - 0.00055 19.3 20.0 0.003 16.9 1.3 3.8 3 0 0 3 3 3 2 zinc-ribbon domain Nudix_N_2 PF14803.6 OPL20810.1 - 0.0024 17.7 13.0 0.78 9.7 2.3 4.6 4 1 0 4 4 4 2 Nudix N-terminal zinc_ribbon_15 PF17032.5 OPL20810.1 - 0.11 13.3 0.5 0.11 13.3 0.5 3.8 4 0 0 4 4 4 0 zinc-ribbon family zf-P11 PF03854.14 OPL20810.1 - 0.14 11.8 5.6 0.47 10.2 0.9 2.4 2 0 0 2 2 2 0 P-11 zinc finger PHF5 PF03660.14 OPL20810.1 - 0.4 10.9 9.1 0.87 9.8 9.1 1.6 1 0 0 1 1 1 0 PHF5-like protein UPF0547 PF10571.9 OPL20810.1 - 0.73 10.0 11.0 4.3 7.5 0.2 3.9 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 zf-primase PF09329.11 OPL20810.1 - 0.74 9.7 4.9 0.95 9.3 2.9 2.3 1 1 1 2 2 2 0 Primase zinc finger Zn_Tnp_IS91 PF14319.6 OPL20810.1 - 1.6 8.8 9.3 3.4 7.8 2.9 2.7 2 0 0 2 2 2 0 Transposase zinc-binding domain zinc_ribbon_9 PF14369.6 OPL20810.1 - 2.8 8.3 6.2 0.8 10.0 0.2 3.0 3 0 0 3 3 2 0 zinc-ribbon DUF3090 PF11290.8 OPL20810.1 - 3.5 7.4 7.2 22 4.8 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3090) YhfH PF14149.6 OPL20810.1 - 6.4 6.8 10.1 25 5.0 0.2 3.8 3 0 0 3 3 3 0 YhfH-like protein RecR PF02132.15 OPL20810.1 - 9.5 5.9 10.8 5.7 6.6 1.0 3.0 3 0 0 3 3 3 0 RecR protein FAM209 PF15206.6 OPL20811.1 - 0.059 13.2 0.0 0.073 12.9 0.0 1.1 1 0 0 1 1 1 0 FAM209 family ABC_tran PF00005.27 OPL20812.1 - 7.3e-27 94.6 0.0 1.3e-26 93.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 OPL20812.1 - 6.2e-11 42.7 0.0 1.3e-07 31.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 OPL20812.1 - 0.018 15.5 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 OPL20812.1 - 0.025 14.3 0.0 0.27 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 OPL20812.1 - 0.029 14.6 0.0 0.37 11.1 0.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF4162 PF13732.6 OPL20812.1 - 0.049 14.3 0.0 0.11 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) Zeta_toxin PF06414.12 OPL20812.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin zf-H2C2_2 PF13465.6 OPL20813.1 - 7.3e-59 193.7 138.1 1e-08 35.2 1.0 19.2 18 2 0 18 18 18 14 Zinc-finger double domain zf-C2H2 PF00096.26 OPL20813.1 - 1.8e-55 182.4 158.3 8.6e-06 25.9 0.8 17.6 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 OPL20813.1 - 1.8e-50 165.2 148.7 0.00021 21.9 1.2 17.6 17 0 0 17 17 17 17 C2H2-type zinc finger zf-C2H2_6 PF13912.6 OPL20813.1 - 1.9e-24 85.1 131.2 0.0014 18.6 0.9 17.7 17 0 0 17 17 17 14 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 OPL20813.1 - 2e-22 78.9 104.5 0.0066 16.7 0.0 17.5 16 1 1 17 17 17 11 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 OPL20813.1 - 2e-19 69.3 108.8 0.0019 18.6 0.1 17.3 17 0 0 17 17 17 11 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 OPL20813.1 - 0.0013 19.1 99.9 0.61 10.5 0.7 15.6 3 3 13 16 16 16 4 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 OPL20813.1 - 0.0052 17.0 83.6 0.46 10.8 2.3 11.0 7 4 3 11 11 11 6 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 OPL20813.1 - 0.017 14.9 0.1 0.017 14.9 0.1 10.9 14 0 0 14 14 14 0 zinc-finger C2H2-type GAGA PF09237.11 OPL20813.1 - 0.039 13.8 7.2 46 3.9 0.0 6.2 6 0 0 6 6 6 0 GAGA factor zinc_ribbon_15 PF17032.5 OPL20813.1 - 0.041 14.6 73.7 0.68 10.7 3.5 9.2 4 1 6 10 10 10 0 zinc-ribbon family PMT2_N PF17987.1 OPL20813.1 - 9.7 6.4 7.6 27 4.9 0.4 3.2 3 0 0 3 3 3 0 Phosphoethanolamine N-methyltransferase 2 N-terminal Aminotran_3 PF00202.21 OPL20814.1 - 1e-21 77.1 0.0 1.2e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Musclin PF11037.8 OPL20816.1 - 0.16 11.9 0.9 0.27 11.1 0.9 1.3 1 0 0 1 1 1 0 Insulin-resistance promoting peptide in skeletal muscle DUF2776 PF10951.8 OPL20819.1 - 0.083 12.1 2.6 0.1 11.9 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2776) E1-E2_ATPase PF00122.20 OPL20819.1 - 0.1 12.1 0.2 0.14 11.6 0.2 1.3 1 0 0 1 1 1 0 E1-E2 ATPase MLANA PF14991.6 OPL20819.1 - 0.23 11.7 1.9 0.66 10.3 1.9 1.7 1 1 0 1 1 1 0 Protein melan-A Gag_p6 PF08705.11 OPL20819.1 - 0.75 10.1 5.5 1.3 9.3 5.2 1.6 1 1 0 1 1 1 0 Gag protein p6 Adeno_E3B PF03376.14 OPL20819.1 - 2.4 8.4 5.5 5.6 7.3 4.8 2.0 2 1 0 2 2 2 0 Adenovirus E3B protein EGF_CA PF07645.15 OPL20820.1 - 1.5e-21 76.3 98.5 1.1e-08 35.1 7.9 6.5 6 1 0 6 6 6 5 Calcium-binding EGF domain cEGF PF12662.7 OPL20820.1 - 1.4e-19 69.7 62.5 2e-07 30.8 2.5 7.6 8 0 0 8 8 8 6 Complement Clr-like EGF-like FXa_inhibition PF14670.6 OPL20820.1 - 7.3e-17 61.4 91.6 1.1e-07 32.0 11.2 6.8 4 1 2 6 6 6 5 Coagulation Factor Xa inhibitory site EGF PF00008.27 OPL20820.1 - 4.5e-05 23.7 88.8 0.0027 18.0 7.4 7.9 6 2 0 6 6 6 3 EGF-like domain EGF_3 PF12947.7 OPL20820.1 - 0.00039 20.6 2.1 0.00039 20.6 2.1 8.5 4 4 2 6 6 6 3 EGF domain hEGF PF12661.7 OPL20820.1 - 0.0019 18.8 14.2 0.0088 16.6 2.7 9.3 8 3 2 10 10 10 5 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 OPL20820.1 - 0.0024 18.1 10.6 0.0024 18.1 10.6 6.9 3 3 2 6 6 6 4 Pvs28 EGF domain fn3 PF00041.21 OPL20821.1 - 0.01 16.2 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 0 Fibronectin type III domain TFIIA_gamma_C PF02751.14 OPL20822.1 - 0.2 11.9 1.2 0.73 10.0 0.0 2.6 3 0 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit EB PF01683.18 OPL20823.1 - 1.5e-10 41.2 34.3 2.8e-06 27.5 9.4 3.1 1 1 2 3 3 3 3 EB module Dickkopf_N PF04706.12 OPL20823.1 - 0.0003 21.2 28.8 0.085 13.3 2.3 3.2 3 0 0 3 3 3 3 Dickkopf N-terminal cysteine-rich region EGF_Tenascin PF18720.1 OPL20823.1 - 5.6 7.1 12.2 0.15 12.2 2.4 2.7 2 0 0 2 2 2 0 Tenascin EGF domain Sulfotransfer_1 PF00685.27 OPL20825.1 - 7.8e-32 110.8 0.9 5.9e-31 107.9 0.9 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 OPL20825.1 - 0.0035 17.7 0.0 0.0058 17.0 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 OPL20825.1 - 0.0041 17.1 0.0 0.0053 16.7 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family IL4_i_Ig PF18258.1 OPL20826.1 - 0.048 13.9 0.1 0.21 11.8 0.1 2.1 1 0 0 1 1 1 0 Interleukin-4 inducing immunoglobulin-binding domain DASH_Dad2 PF08654.10 OPL20826.1 - 0.056 13.9 1.2 0.11 13.0 0.0 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad2 FtsJ PF01728.19 OPL20827.1 - 1.5e-27 96.8 0.0 2.2e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Lipocalin_4 PF13648.6 OPL20827.1 - 0.021 15.8 0.4 8.9 7.4 0.1 2.5 2 0 0 2 2 2 0 Lipocalin-like domain AHD PF17793.1 OPL20827.1 - 0.023 14.5 2.0 0.11 12.4 0.1 2.6 3 0 0 3 3 3 0 ANC1 homology domain (AHD) Methyltrans_Mon PF14314.6 OPL20827.1 - 0.036 12.1 0.0 0.053 11.6 0.0 1.2 1 0 0 1 1 1 0 Virus-capping methyltransferase DUF717 PF05338.12 OPL20828.1 - 0.12 12.5 0.2 0.29 11.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF717) Sugar_tr PF00083.24 OPL20830.1 - 9.6e-06 24.7 0.6 1.3e-05 24.3 0.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 OPL20830.1 - 9.8e-05 21.4 1.6 0.0001 21.3 1.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily GPS PF01825.21 OPL20831.1 - 0.0028 18.2 5.7 0.0067 16.9 5.7 1.7 1 1 0 1 1 1 1 GPCR proteolysis site, GPS, motif DUF997 PF06196.12 OPL20831.1 - 0.11 12.6 2.0 0.21 11.6 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF997) UAE_UbL PF14732.6 OPL20832.1 - 1.1e-15 58.0 0.2 2.7e-15 56.7 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain C1q PF00386.21 OPL20834.1 - 1.7e-16 60.6 0.0 2.7e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 C1q domain APG17 PF04108.12 OPL20834.1 - 0.03 13.4 0.0 0.04 13.0 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 RVT_1 PF00078.27 OPL20835.1 - 1.5e-15 57.3 0.1 1.9e-15 57.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Folate_rec PF03024.14 OPL20837.1 - 6.4e-21 75.0 5.0 7.1e-21 74.8 5.0 1.0 1 0 0 1 1 1 1 Folate receptor family FAM163 PF15069.6 OPL20838.1 - 0.059 13.8 0.1 0.082 13.3 0.1 1.2 1 0 0 1 1 1 0 FAM163 family EphA2_TM PF14575.6 OPL20838.1 - 0.075 13.9 0.0 0.14 13.1 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain BacA PF02673.18 OPL20838.1 - 0.076 12.7 0.0 0.097 12.4 0.0 1.0 1 0 0 1 1 1 0 Bacitracin resistance protein BacA LAX PF15681.5 OPL20838.1 - 0.16 10.8 0.1 0.21 10.4 0.1 1.1 1 0 0 1 1 1 0 Lymphocyte activation family X TMEM154 PF15102.6 OPL20838.1 - 0.18 11.7 0.0 0.23 11.3 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family Arf PF00025.21 OPL20839.1 - 1.9e-26 92.6 0.0 2.2e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 OPL20839.1 - 0.00056 19.2 0.0 0.001 18.3 0.0 1.4 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 OPL20839.1 - 0.0011 18.4 0.0 0.0014 18.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit CARD_2 PF16739.5 OPL20839.1 - 0.17 11.9 0.1 0.36 10.9 0.0 1.5 2 0 0 2 2 2 0 Caspase recruitment domain zf-C2H2 PF00096.26 OPL20841.1 - 4.6e-26 89.8 33.4 2.4e-06 27.7 1.1 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 OPL20841.1 - 7.1e-20 70.0 31.7 0.00011 22.8 0.8 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 OPL20841.1 - 4.7e-19 67.9 35.3 1.8e-07 31.3 0.3 5.9 6 0 0 6 6 5 5 Zinc-finger double domain zf-C2H2_jaz PF12171.8 OPL20841.1 - 1.4e-13 50.8 14.5 0.0031 17.7 0.4 5.2 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 OPL20841.1 - 2.8e-10 39.9 30.0 0.0015 18.5 0.7 6.2 6 0 0 6 6 6 5 C2H2-type zinc finger zf-met PF12874.7 OPL20841.1 - 4.2e-09 36.5 18.3 0.081 13.3 0.2 5.5 5 0 0 5 5 5 4 Zinc-finger of C2H2 type PyrI_C PF02748.15 OPL20841.1 - 0.015 15.2 19.5 1.1 9.2 4.3 5.3 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HE PF16278.5 OPL20841.1 - 0.016 15.6 33.9 0.097 13.1 0.3 5.8 3 1 2 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 OPL20841.1 - 0.017 15.0 16.3 2.8 7.9 0.8 5.3 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.5 OPL20841.1 - 0.025 15.3 0.6 0.025 15.3 0.6 3.2 3 1 0 3 3 1 0 zinc-ribbon family zf-BED PF02892.15 OPL20841.1 - 0.044 13.8 0.2 0.044 13.8 0.2 5.3 2 2 3 5 5 5 0 BED zinc finger Zn-ribbon_8 PF09723.10 OPL20841.1 - 0.075 13.2 19.7 0.22 11.7 2.5 4.4 3 1 1 4 4 4 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 OPL20841.1 - 0.34 11.3 19.2 0.72 10.2 0.9 5.1 2 1 4 6 6 6 0 C2H2 type zinc-finger (2 copies) zf_ZIC PF18366.1 OPL20841.1 - 0.67 10.1 10.1 4.2 7.5 0.2 4.6 3 1 2 5 5 5 0 Zic proteins zinc finger domain DUF4764 PF15961.5 OPL20841.1 - 0.78 8.3 7.5 1.2 7.7 1.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4764) ADK_lid PF05191.14 OPL20841.1 - 1.1 9.3 15.5 5.4 7.1 1.2 4.2 2 1 1 3 3 3 0 Adenylate kinase, active site lid zf-AN1 PF01428.16 OPL20841.1 - 2 8.6 28.0 7.1 6.9 0.1 5.7 6 0 0 6 6 5 0 AN1-like Zinc finger Sprouty PF05210.13 OPL20841.1 - 6.7 7.2 18.0 0.13 12.6 2.1 2.6 2 1 0 2 2 2 0 Sprouty protein (Spry) NHL PF01436.21 OPL20842.1 - 4e-14 51.8 9.6 1.1e-05 25.2 0.1 5.2 5 0 0 5 5 5 2 NHL repeat zf-RING_UBOX PF13445.6 OPL20842.1 - 4.2e-11 42.7 5.1 4.2e-11 42.7 5.1 2.3 3 1 1 4 4 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 OPL20842.1 - 2.7e-09 36.8 8.3 5.5e-09 35.8 8.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL20842.1 - 5.4e-08 33.0 8.3 1.3e-07 31.8 8.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 OPL20842.1 - 2.7e-07 30.6 10.1 6.4e-07 29.4 10.1 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING DUF5128 PF17170.4 OPL20842.1 - 1.1e-06 28.0 0.5 0.01 15.0 0.1 2.6 1 1 2 3 3 3 2 6-bladed beta-propeller zf-C3HC4_2 PF13923.6 OPL20842.1 - 8.2e-06 25.6 9.7 6.1e-05 22.8 9.9 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 OPL20842.1 - 2.1e-05 24.4 7.8 4.8e-05 23.2 7.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 OPL20842.1 - 2.2e-05 24.2 5.9 2.2e-05 24.2 5.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 OPL20842.1 - 0.00023 20.9 6.2 0.0003 20.5 4.4 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit SGL PF08450.12 OPL20842.1 - 0.00035 20.2 0.0 0.0048 16.5 0.0 2.6 3 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region DUF4934 PF16288.5 OPL20842.1 - 0.0022 17.9 0.4 1.7 8.6 0.1 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4934) Prok-RING_4 PF14447.6 OPL20842.1 - 0.0058 16.5 9.3 0.028 14.3 7.7 2.8 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 OPL20842.1 - 0.081 13.0 1.9 0.78 9.8 2.1 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 OPL20842.1 - 0.18 11.6 7.0 0.46 10.3 6.0 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 OPL20842.1 - 0.47 10.8 5.2 1.4 9.3 5.2 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 OPL20842.1 - 0.53 10.2 5.4 0.58 10.1 3.4 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein PHD_2 PF13831.6 OPL20843.1 - 0.046 13.3 0.2 0.069 12.7 0.2 1.2 1 0 0 1 1 1 0 PHD-finger HEPN_DZIP3 PF18738.1 OPL20844.1 - 3.6e-10 39.8 0.0 5.6e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN HEPN_RiboL-PSP PF18735.1 OPL20844.1 - 0.00011 22.2 0.6 0.0002 21.3 0.6 1.8 1 1 0 1 1 1 1 RiboL-PSP-HEPN DUF4559 PF15112.6 OPL20844.1 - 0.091 12.4 0.0 0.21 11.2 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) PAPS_reduct PF01507.19 OPL20845.1 - 0.048 13.7 0.4 0.074 13.1 0.4 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Thioredoxin PF00085.20 OPL20848.1 - 7.9e-23 80.4 0.1 9.8e-23 80.1 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 OPL20848.1 - 0.0011 19.2 0.0 0.0016 18.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 OPL20848.1 - 0.0019 17.6 0.0 0.002 17.5 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 OPL20848.1 - 0.012 15.6 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_2 PF13098.6 OPL20848.1 - 0.017 15.6 0.2 0.15 12.6 0.2 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_9 PF14595.6 OPL20848.1 - 0.035 13.9 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DUF953 PF06110.11 OPL20848.1 - 0.044 13.4 0.3 0.073 12.7 0.3 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Redoxin PF08534.10 OPL20848.1 - 0.073 12.8 0.2 0.11 12.2 0.1 1.3 1 1 0 1 1 1 0 Redoxin Thioredoxin_5 PF13743.6 OPL20848.1 - 0.19 11.4 0.1 8.7 6.0 0.1 2.0 1 1 1 2 2 2 0 Thioredoxin Peptidase_S8 PF00082.22 OPL20849.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Subtilase family RGS PF00615.19 OPL20851.1 - 5e-06 26.8 0.2 1.1e-05 25.7 0.2 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Neil1-DNA_bind PF09292.10 OPL20851.1 - 0.074 13.0 0.4 0.17 11.9 0.4 1.6 1 0 0 1 1 1 0 Endonuclease VIII-like 1, DNA bind RTBV_P12 PF06361.11 OPL20851.1 - 0.1 13.0 0.2 1.8 9.0 0.1 2.2 1 1 1 2 2 2 0 Rice tungro bacilliform virus P12 protein TSP_1 PF00090.19 OPL20853.1 - 7.5e-13 48.5 7.2 2.4e-12 46.9 7.2 1.9 1 0 0 1 1 1 1 Thrombospondin type 1 domain CUB PF00431.20 OPL20853.1 - 2.1e-10 40.9 0.0 5.2e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 CUB domain Sushi PF00084.20 OPL20853.1 - 1.4e-07 32.0 0.7 4.6e-07 30.3 0.3 2.2 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) MACPF PF01823.19 OPL20855.1 - 6.5e-27 95.0 0.1 7.5e-27 94.8 0.1 1.0 1 0 0 1 1 1 1 MAC/Perforin domain ResIII PF04851.15 OPL20856.1 - 3.7e-06 27.0 0.1 4.3e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 OPL20856.1 - 1.2e-05 25.1 0.0 1.3e-05 25.1 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 OPL20856.1 - 0.04 14.2 0.0 0.045 14.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain GST_N PF02798.20 OPL20857.1 - 1.4e-07 31.8 0.0 1.8e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 OPL20857.1 - 0.00017 21.9 0.0 0.00023 21.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 OPL20857.1 - 0.016 15.5 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 OPL20857.1 - 0.15 12.9 0.0 0.17 12.6 0.0 1.1 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Myb_DNA-bind_5 PF13873.6 OPL20858.1 - 6.7e-08 32.5 2.2 6.7e-08 32.5 2.2 1.7 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 OPL20858.1 - 0.0018 18.6 1.3 0.0019 18.5 0.5 1.5 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain RA PF00788.23 OPL20859.1 - 1.2e-06 29.0 0.8 8.8e-06 26.3 0.8 2.2 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain CSD PF00313.22 OPL20860.1 - 3.6e-06 26.7 0.0 5.8e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain NADH_oxidored PF08040.11 OPL20861.1 - 0.0071 16.0 1.7 3.8 7.3 0.0 3.1 3 1 0 3 3 3 2 MNLL subunit Ric8 PF10165.9 OPL20861.1 - 0.0096 15.0 1.0 0.011 14.8 1.0 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Helicase_C PF00271.31 OPL20861.1 - 0.04 14.2 1.2 9.8 6.6 0.0 2.8 2 1 1 3 3 3 0 Helicase conserved C-terminal domain DNA_pol_E_B PF04042.16 OPL20861.1 - 0.091 12.1 0.3 3.1 7.1 0.0 2.8 2 1 1 3 3 3 0 DNA polymerase alpha/epsilon subunit B Phage_TAC_11 PF11836.8 OPL20861.1 - 0.2 11.8 0.0 30 4.8 0.0 2.2 1 1 1 2 2 2 0 Phage tail tube protein, GTA-gp10 TSCPD PF12637.7 OPL20862.1 - 0.028 14.7 0.2 0.06 13.6 0.1 1.6 2 0 0 2 2 2 0 TSCPD domain FeoB_Cyto PF17910.1 OPL20862.1 - 0.087 13.4 0.1 0.11 13.1 0.1 1.2 1 0 0 1 1 1 0 FeoB cytosolic helical domain TSP_1 PF00090.19 OPL20863.1 - 4.9e-19 68.3 20.0 2.1e-09 37.4 5.8 2.1 2 0 0 2 2 2 2 Thrombospondin type 1 domain CxC6 PF18721.1 OPL20863.1 - 0.014 15.6 10.6 0.68 10.2 2.3 2.3 1 1 1 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases Alginate_lyase PF05426.12 OPL20863.1 - 0.066 12.7 0.4 7.3 6.0 0.1 2.1 2 0 0 2 2 2 0 Alginate lyase DUF1962 PF09227.10 OPL20863.1 - 0.97 9.8 14.2 8.9 6.8 7.0 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1962) Antistasin PF02822.14 OPL20863.1 - 3.5 8.4 12.4 3.6 8.3 0.3 3.5 4 0 0 4 4 4 0 Antistasin family C1q PF00386.21 OPL20864.1 - 1.2e-21 77.2 0.2 1.6e-21 76.8 0.2 1.2 1 0 0 1 1 1 1 C1q domain bZIP_1 PF00170.21 OPL20865.1 - 3.4e-06 27.1 5.2 3.4e-06 27.1 5.2 2.3 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 OPL20865.1 - 0.015 15.4 8.6 0.015 15.4 8.6 2.1 2 1 0 2 2 2 0 Basic region leucine zipper bZIP_Maf PF03131.17 OPL20865.1 - 0.25 11.9 9.1 0.21 12.1 3.9 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor CDCA PF18484.1 OPL20866.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Cadmium carbonic anhydrase repeat GLTP PF08718.11 OPL20867.1 - 1.2e-22 80.8 0.0 3.6e-22 79.2 0.0 1.7 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) Dynein_light PF01221.18 OPL20870.1 - 2.5e-24 85.4 1.7 3.5e-24 84.9 1.7 1.3 1 0 0 1 1 1 1 Dynein light chain type 1 CoaE PF01121.20 OPL20871.1 - 5.4e-34 117.4 0.0 6.4e-34 117.2 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 OPL20871.1 - 0.035 14.6 0.6 0.047 14.2 0.6 1.5 1 1 0 1 1 1 0 AAA domain Y_phosphatase PF00102.27 OPL20872.1 - 0.00086 18.9 0.1 0.0013 18.3 0.1 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase T4_Gp59_N PF08993.10 OPL20872.1 - 0.018 15.4 0.3 0.034 14.6 0.2 1.5 1 1 1 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase fn3 PF00041.21 OPL20873.1 - 1.1e-09 38.5 0.0 2e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-C2H2_jaz PF12171.8 OPL20874.1 - 1.2e-05 25.4 6.4 3.4e-05 24.0 6.4 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF4187 PF13821.6 OPL20874.1 - 0.012 15.4 0.8 0.028 14.2 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) zf-C2H2_2 PF12756.7 OPL20874.1 - 0.023 15.0 2.9 0.023 15.0 2.9 2.7 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 OPL20874.1 - 0.85 10.1 12.7 0.033 14.6 6.1 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FA_synthesis PF02504.15 OPL20875.1 - 0.012 14.7 0.1 0.017 14.2 0.1 1.1 1 0 0 1 1 1 0 Fatty acid synthesis protein Macro PF01661.21 OPL20876.1 - 5.7e-09 36.0 0.0 1.1e-08 35.1 0.0 1.5 1 1 0 1 1 1 1 Macro domain MSL2-CXC PF16682.5 OPL20876.1 - 0.03 14.4 0.4 0.075 13.2 0.4 1.7 1 0 0 1 1 1 0 CXC domain of E3 ubiquitin-protein ligase MSL2 Fibrinogen_C PF00147.18 OPL20877.1 - 1.8e-06 27.9 0.6 2.8e-06 27.3 0.1 1.5 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain Sulfotransfer_3 PF13469.6 OPL20878.1 - 0.0062 16.9 0.0 0.0066 16.8 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family UPF0640 PF15114.6 OPL20878.1 - 0.89 9.4 3.8 14 5.5 0.4 2.5 2 1 0 2 2 2 0 Uncharacterised protein family UPF0640 WSC PF01822.19 OPL20879.1 - 9.1e-17 61.0 6.2 1.3e-16 60.5 6.2 1.2 1 0 0 1 1 1 1 WSC domain TSP_1 PF00090.19 OPL20880.1 - 3.8e-11 43.0 4.9 3.8e-11 43.0 4.9 4.0 3 1 1 4 4 4 1 Thrombospondin type 1 domain EGF PF00008.27 OPL20880.1 - 4e-07 30.2 36.5 0.00041 20.6 11.0 4.1 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.7 OPL20880.1 - 0.0014 19.1 6.2 0.0014 19.1 6.2 5.2 6 0 0 6 6 6 2 Human growth factor-like EGF EGF_CA PF07645.15 OPL20880.1 - 0.0016 18.6 11.4 0.0016 18.6 11.4 4.5 3 2 1 4 4 4 2 Calcium-binding EGF domain CUB PF00431.20 OPL20882.1 - 4e-29 101.2 0.1 5.9e-29 100.6 0.1 1.3 1 0 0 1 1 1 1 CUB domain Rad21_Rec8_N PF04825.13 OPL20883.1 - 4.2e-12 46.2 0.0 6.6e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Beta-Casp PF10996.8 OPL20883.1 - 0.073 13.4 0.0 0.084 13.2 0.0 1.2 1 0 0 1 1 1 0 Beta-Casp domain Lamp PF01299.17 OPL20884.1 - 4.8e-10 39.5 1.1 1.8e-05 24.6 0.0 3.0 3 0 0 3 3 3 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 OPL20884.1 - 3.9e-05 23.5 0.0 6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) DUF5524 PF17662.1 OPL20885.1 - 4.4e-16 59.1 5.5 2e-15 56.9 5.5 1.9 1 1 0 1 1 1 1 Family of unknown function (DUF5524) RIFIN PF02009.16 OPL20886.1 - 0.0002 21.4 0.0 0.00026 21.0 0.0 1.1 1 0 0 1 1 1 1 Rifin LapA_dom PF06305.11 OPL20886.1 - 0.0013 18.5 0.0 0.0013 18.5 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain RCR PF12273.8 OPL20886.1 - 0.0061 17.2 0.2 0.0061 17.2 0.2 2.0 3 0 0 3 3 3 1 Chitin synthesis regulation, resistance to Congo red TMEM154 PF15102.6 OPL20886.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Orf78 PF06024.12 OPL20886.1 - 0.013 15.7 0.7 0.077 13.3 0.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) SKG6 PF08693.10 OPL20886.1 - 0.015 14.7 2.9 0.037 13.4 2.9 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EphA2_TM PF14575.6 OPL20886.1 - 0.058 14.3 0.5 0.14 13.1 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF5305 PF17231.2 OPL20886.1 - 0.088 12.2 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) SecG PF03840.14 OPL20886.1 - 0.14 12.3 0.0 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 Preprotein translocase SecG subunit PDCD7 PF16021.5 OPL20887.1 - 1.5e-10 40.8 18.0 5.2e-10 38.9 18.0 1.7 1 1 0 1 1 1 1 Programmed cell death protein 7 tRNA_NucTran2_2 PF13735.6 OPL20887.1 - 0.012 15.6 2.1 0.02 14.9 2.1 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Peptidase_S46 PF10459.9 OPL20887.1 - 0.29 9.7 6.7 0.34 9.5 6.7 1.1 1 0 0 1 1 1 0 Peptidase S46 MmgE_PrpD PF03972.14 OPL20887.1 - 0.39 9.2 1.8 0.44 9.0 1.8 1.1 1 0 0 1 1 1 0 MmgE/PrpD family Fungal_TACC PF12709.7 OPL20887.1 - 0.77 10.3 17.8 0.2 12.1 4.9 3.0 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins PSK_trans_fac PF07704.11 OPL20887.1 - 1.1 10.0 7.3 0.4 11.5 0.6 2.1 2 0 0 2 2 2 0 Rv0623-like transcription factor DUF1943 PF09172.11 OPL20887.1 - 6.2 6.0 8.0 7.6 5.7 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) FliD_N PF02465.18 OPL20887.1 - 8.7 7.1 7.3 1.4 9.6 1.0 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus GHMP_kinases_N PF00288.26 OPL20888.1 - 1e-12 48.1 1.6 1e-12 48.1 0.8 1.4 2 0 0 2 2 2 1 GHMP kinases N terminal domain Peptidase_C1 PF00112.23 OPL20888.1 - 0.093 12.8 0.8 0.12 12.5 0.8 1.2 1 0 0 1 1 1 0 Papain family cysteine protease Death PF00531.22 OPL20889.1 - 2e-05 24.6 0.1 0.00023 21.2 0.0 2.4 2 0 0 2 2 2 1 Death domain Cnn_1N PF07989.11 OPL20889.1 - 0.013 15.6 2.4 0.016 15.3 0.5 2.1 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Fasciclin PF02469.22 OPL20890.1 - 2.8e-06 27.6 0.0 3.1e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Fasciclin domain Ependymin PF00811.18 OPL20891.1 - 6.6e-14 52.3 0.1 9.6e-14 51.7 0.1 1.2 1 0 0 1 1 1 1 Ependymin PheRS_DBD2 PF18554.1 OPL20892.1 - 0.089 12.8 4.8 0.14 12.2 0.5 3.1 3 0 0 3 3 3 0 PheRS DNA binding domain 2 Creatinase_N PF01321.18 OPL20893.1 - 5.3e-13 49.8 0.0 1.3e-11 45.3 0.0 2.1 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Creatinase_N_2 PF16189.5 OPL20893.1 - 3.7e-11 43.4 0.0 7.2e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Tudor_2 PF18104.1 OPL20893.1 - 0.19 11.5 0.1 0.33 10.7 0.1 1.4 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain Xpo1 PF08389.12 OPL20894.1 - 1.3e-40 138.9 2.4 3.8e-40 137.4 0.5 2.4 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.22 OPL20894.1 - 0.043 14.1 0.0 58 4.3 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat p450 PF00067.22 OPL20895.1 - 7.2e-96 321.7 0.0 8.4e-96 321.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tma16 PF11176.8 OPL20895.1 - 0.04 13.8 0.2 0.08 12.8 0.2 1.4 1 0 0 1 1 1 0 Translation machinery-associated protein 16 Neur_chan_LBD PF02931.23 OPL20896.1 - 1.9e-09 37.3 0.0 3e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain zf-C2H2 PF00096.26 OPL20897.1 - 0.013 15.9 0.4 0.029 14.8 0.4 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type Tudor_2 PF18104.1 OPL20897.1 - 0.088 12.5 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain RINGv PF12906.7 OPL20899.1 - 0.0023 18.0 2.6 0.0073 16.4 2.6 1.8 1 1 0 1 1 1 1 RING-variant domain GTP_EFTU PF00009.27 OPL20900.1 - 0.0012 18.5 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 OPL20900.1 - 0.11 12.6 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF836 PF05768.14 OPL20901.1 - 3.4e-16 59.4 0.2 4.5e-16 59.0 0.2 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 OPL20901.1 - 0.00024 21.3 0.1 0.00041 20.5 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin SID PF11778.8 OPL20901.1 - 0.03 14.4 0.7 0.042 14.0 0.4 1.5 1 1 0 1 1 1 0 Septation initiation ShK PF01549.24 OPL20902.1 - 9.3e-33 112.5 79.7 6e-09 36.3 11.9 5.1 5 0 0 5 5 5 5 ShK domain-like zf-CCCH PF00642.24 OPL20902.1 - 0.00036 20.4 16.6 0.31 11.0 0.1 5.5 4 1 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Tetraspanin PF00335.20 OPL20903.1 - 1.2e-22 80.7 2.5 1.4e-22 80.6 2.5 1.0 1 0 0 1 1 1 1 Tetraspanin family Sulfatase PF00884.23 OPL20904.1 - 3.2e-32 112.2 0.1 4.3e-32 111.7 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Phosphoesterase PF04185.14 OPL20904.1 - 0.031 13.5 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 Phosphoesterase family DUF229 PF02995.17 OPL20904.1 - 0.076 11.6 0.0 0.086 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) EGF_MSP1_1 PF12946.7 OPL20905.1 - 0.0024 17.9 3.4 0.0024 17.9 3.4 2.8 2 0 0 2 2 2 1 MSP1 EGF domain 1 TIL PF01826.17 OPL20905.1 - 0.0031 17.7 24.7 0.084 13.1 8.5 2.2 1 1 0 2 2 2 2 Trypsin Inhibitor like cysteine rich domain EB PF01683.18 OPL20905.1 - 0.0035 17.6 23.4 0.0065 16.7 14.1 2.2 1 1 1 2 2 2 2 EB module Phage_fiber_C PF06820.12 OPL20905.1 - 0.16 12.3 0.0 0.43 11.0 0.0 1.7 1 1 1 2 2 2 0 Putative prophage tail fibre C-terminus BmKX PF09132.10 OPL20905.1 - 7 6.7 10.6 0.44 10.6 0.6 2.9 2 1 0 2 2 2 0 BmKX dCMP_cyt_deam_1 PF00383.23 OPL20906.1 - 1e-15 57.4 0.1 1.2e-15 57.2 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 OPL20906.1 - 8.8e-12 45.4 0.3 2.6e-10 40.6 0.1 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 OPL20906.1 - 0.0018 17.9 0.8 0.74 9.4 0.1 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases NHL PF01436.21 OPL20907.1 - 5.3e-26 89.3 1.7 4.7e-07 29.5 0.1 7.3 7 0 0 7 7 7 5 NHL repeat Thioredoxin_8 PF13905.6 OPL20907.1 - 2.4e-10 40.6 0.5 8e-10 38.9 0.2 2.1 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin PF00085.20 OPL20907.1 - 0.00098 19.1 0.0 1.3 9.0 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Redoxin PF08534.10 OPL20907.1 - 0.0078 15.9 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Redoxin Baculo_FP PF03258.14 OPL20907.1 - 0.047 13.8 0.1 0.086 13.0 0.1 1.4 1 0 0 1 1 1 0 Baculovirus FP protein NAD_kinase PF01513.21 OPL20908.1 - 0.021 14.0 0.4 0.025 13.8 0.5 1.3 1 1 0 1 1 1 0 ATP-NAD kinase DAGK_cat PF00781.24 OPL20908.1 - 0.07 12.7 0.0 0.087 12.4 0.0 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain CUE PF02845.16 OPL20908.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 CUE domain ubiquitin PF00240.23 OPL20909.1 - 6.6e-12 45.0 0.3 4.4e-11 42.4 0.5 2.2 2 1 0 2 2 2 1 Ubiquitin family TerD PF02342.18 OPL20909.1 - 2e-07 30.7 0.0 3.4e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 TerD domain Rad60-SLD PF11976.8 OPL20909.1 - 0.0043 16.8 0.0 0.013 15.3 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 OPL20909.1 - 0.055 13.9 0.0 0.098 13.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain PB1 PF00564.24 OPL20909.1 - 0.15 12.0 0.0 0.65 10.0 0.0 2.0 2 0 0 2 2 2 0 PB1 domain Nrf1_DNA-bind PF10491.9 OPL20909.1 - 0.16 11.7 0.0 4.6 6.9 0.0 2.2 2 0 0 2 2 2 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Ependymin PF00811.18 OPL20910.1 - 3e-13 50.1 0.0 3.9e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Ependymin MIF4G PF02854.19 OPL20911.1 - 1.8e-05 24.5 2.0 2.8e-05 23.9 2.0 1.3 1 0 0 1 1 1 1 MIF4G domain IBP39 PF11422.8 OPL20911.1 - 0.06 13.1 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Initiator binding protein 39 kDa PAN_1 PF00024.26 OPL20913.1 - 3.2e-10 39.8 13.7 1.1e-05 25.2 2.6 2.6 1 1 1 2 2 2 2 PAN domain PAN_2 PF08276.11 OPL20913.1 - 4.8e-05 23.4 10.0 0.003 17.6 1.1 2.7 3 0 0 3 3 3 2 PAN-like domain Ifi-6-16 PF06140.13 OPL20913.1 - 0.00069 19.5 8.9 0.001 19.0 8.9 1.2 1 0 0 1 1 1 1 Interferon-induced 6-16 family PAN_4 PF14295.6 OPL20913.1 - 0.0014 18.5 9.8 0.021 14.7 0.9 3.2 3 0 0 3 3 3 2 PAN domain PAN_3 PF08277.12 OPL20913.1 - 2.7 7.8 16.2 1.5 8.7 1.4 3.4 2 1 2 4 4 4 0 PAN-like domain EMP24_GP25L PF01105.24 OPL20914.1 - 5.2e-18 65.6 0.1 6.3e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 OPL20914.1 - 0.078 13.2 0.0 0.2 11.9 0.0 1.6 1 1 1 2 2 2 0 SdrD B-like domain Tnp_DNA_bind PF14706.6 OPL20915.1 - 0.13 12.1 0.0 0.35 10.8 0.0 1.7 1 0 0 1 1 1 0 Transposase DNA-binding Fapy_DNA_glyco PF01149.24 OPL20916.1 - 0.00057 20.5 6.7 3.4 8.3 0.1 5.0 2 1 1 4 4 4 3 Formamidopyrimidine-DNA glycosylase N-terminal domain Vut_1 PF02592.15 OPL20916.1 - 0.073 13.4 21.8 26 5.1 0.1 6.0 1 1 4 5 5 5 0 Putative vitamin uptake transporter TBCC PF07986.12 OPL20916.1 - 1 9.1 6.5 2.5 7.8 6.5 1.7 1 0 0 1 1 1 0 Tubulin binding cofactor C Spectrin PF00435.21 OPL20917.1 - 2.8e-16 59.9 58.2 3.9e-06 27.3 5.6 6.4 5 1 1 6 6 6 5 Spectrin repeat GAS PF13851.6 OPL20917.1 - 8.5e-05 22.0 60.2 0.0012 18.2 6.4 5.7 2 2 2 5 5 5 3 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 OPL20917.1 - 0.0035 17.4 32.7 0.2 11.7 0.2 5.6 3 2 1 5 5 5 2 Laminin Domain II APG17 PF04108.12 OPL20917.1 - 0.019 14.1 39.0 0.21 10.7 2.1 5.6 1 1 1 3 3 3 0 Autophagy protein Apg17 NPV_P10 PF05531.12 OPL20917.1 - 0.19 12.2 34.1 9.1 6.8 0.2 8.1 5 3 1 6 6 6 0 Nucleopolyhedrovirus P10 protein DUF4298 PF14131.6 OPL20917.1 - 0.43 10.6 37.5 0.28 11.2 0.3 7.9 5 4 2 9 9 9 0 Domain of unknown function (DUF4298) PilJ PF13675.6 OPL20917.1 - 0.65 10.0 28.6 1.4 9.0 0.1 6.1 4 2 2 6 6 6 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1664 PF07889.12 OPL20917.1 - 0.72 9.9 30.7 2.5 8.2 5.4 6.3 2 2 4 7 7 7 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 OPL20917.1 - 0.82 8.5 58.9 0.031 13.1 7.2 5.1 1 1 4 5 5 5 0 Spc7 kinetochore protein FapA PF03961.13 OPL20917.1 - 2 7.0 42.2 0.26 9.9 9.7 5.0 1 1 2 5 5 5 0 Flagellar Assembly Protein A Peptidase_C65 PF10275.9 OPL20917.1 - 2.2 7.7 22.1 1.6 8.1 0.5 4.7 3 2 1 4 4 4 0 Peptidase C65 Otubain FlaC_arch PF05377.11 OPL20917.1 - 3.5 8.1 0.0 3.5 8.1 0.0 7.4 7 3 1 8 8 7 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 OPL20917.1 - 4.3 6.5 38.7 0.86 8.8 6.1 4.6 3 1 1 4 4 4 0 TMPIT-like protein DUF4239 PF14023.6 OPL20917.1 - 5.1 6.8 13.1 19 4.9 0.1 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4239) Lebercilin PF15619.6 OPL20917.1 - 8.7 5.9 57.9 0.32 10.6 5.3 4.9 2 1 3 5 5 4 0 Ciliary protein causing Leber congenital amaurosis disease DUF805 PF05656.14 OPL20918.1 - 0.43 11.0 5.8 0.64 10.4 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) Fumarate_red_D PF02313.17 OPL20918.1 - 0.49 10.5 6.0 1.2 9.3 5.9 1.7 1 1 1 2 2 2 0 Fumarate reductase subunit D Octopine_DH PF02317.17 OPL20919.1 - 6.7e-33 113.9 0.7 2e-32 112.3 0.1 1.9 2 0 0 2 2 2 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Rer1 PF03248.13 OPL20921.1 - 0.00085 19.1 0.2 0.0017 18.1 0.1 1.5 2 0 0 2 2 2 1 Rer1 family ABC_tran PF00005.27 OPL20922.1 - 7.7e-28 97.7 0.0 1e-27 97.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 OPL20922.1 - 0.001 18.9 0.1 0.71 9.6 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 OPL20922.1 - 0.0016 18.5 0.1 0.0025 17.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF87 PF01935.17 OPL20922.1 - 0.0066 16.6 0.2 0.012 15.8 0.2 1.3 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_16 PF13191.6 OPL20922.1 - 0.012 16.0 0.0 0.018 15.5 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 OPL20922.1 - 0.014 15.0 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 OPL20922.1 - 0.026 14.3 0.1 0.076 12.8 0.1 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 OPL20922.1 - 0.042 14.1 0.0 0.37 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 OPL20922.1 - 0.047 13.6 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase DUF815 PF05673.13 OPL20922.1 - 0.064 12.4 0.0 0.089 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SMC_N PF02463.19 OPL20922.1 - 0.065 12.7 0.0 1.5 8.2 0.1 2.0 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain TrwB_AAD_bind PF10412.9 OPL20922.1 - 0.068 12.1 0.2 0.68 8.8 0.1 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.6 OPL20922.1 - 0.12 12.0 0.0 0.42 10.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 OPL20922.1 - 0.21 12.1 0.1 0.38 11.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain Peptidase_C14 PF00656.22 OPL20923.1 - 4.2e-22 79.3 0.2 5.1e-22 79.0 0.2 1.1 1 0 0 1 1 1 1 Caspase domain Ras PF00071.22 OPL20924.1 - 6.3e-39 133.2 0.1 7.6e-39 132.9 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL20924.1 - 3.7e-18 65.9 0.1 8.5e-18 64.7 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 OPL20924.1 - 1.4e-07 31.1 0.1 2e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 OPL20924.1 - 0.0048 16.3 0.0 0.0065 15.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 OPL20924.1 - 0.026 14.1 0.0 0.25 10.8 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 OPL20924.1 - 0.089 12.8 0.0 0.27 11.3 0.0 1.7 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Kazal_1 PF00050.21 OPL20925.1 - 3.9e-24 84.4 55.2 4.4e-06 26.6 10.2 4.8 1 1 2 4 4 4 4 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 OPL20925.1 - 2e-13 50.2 81.1 0.00012 22.2 10.8 5.4 4 1 2 6 6 6 4 Kazal-type serine protease inhibitor domain Metallothio_5 PF02067.15 OPL20925.1 - 2.5 8.3 90.6 0.45 10.7 14.9 5.6 5 1 0 5 5 5 0 Metallothionein family 5 KinB_sensor PF16767.5 OPL20926.1 - 0.0094 16.4 0.0 0.012 16.0 0.0 1.2 1 0 0 1 1 1 1 Sensor domain of alginate biosynthesis sensor protein KinB COMMD1_N PF17221.3 OPL20926.1 - 0.12 12.6 0.1 0.35 11.2 0.0 1.7 1 1 0 1 1 1 0 COMMD1 N-terminal domain Cadherin_C_2 PF16492.5 OPL20927.1 - 0.00017 22.2 0.0 0.00039 21.1 0.0 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal EphA2_TM PF14575.6 OPL20927.1 - 0.015 16.2 0.8 0.035 15.0 0.8 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 OPL20927.1 - 0.037 15.0 0.1 0.083 13.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Hexokinase_2 PF03727.16 OPL20927.1 - 0.04 13.4 0.0 0.072 12.5 0.0 1.4 1 1 0 1 1 1 0 Hexokinase Orf78 PF06024.12 OPL20927.1 - 0.043 14.1 0.7 0.11 12.8 0.1 1.9 2 0 0 2 2 2 0 Orf78 (ac78) Vpu PF00558.19 OPL20927.1 - 0.075 12.8 0.3 0.13 12.0 0.3 1.4 1 0 0 1 1 1 0 Vpu protein Phage_Coat_Gp8 PF05371.12 OPL20927.1 - 1.7 8.5 5.6 1.6 8.6 3.5 1.9 2 0 0 2 2 2 0 Phage major coat protein, Gp8 Evr1_Alr PF04777.13 OPL20928.1 - 1.3e-29 102.6 3.3 2.2e-29 101.9 3.3 1.4 1 0 0 1 1 1 1 Erv1 / Alr family Ig_3 PF13927.6 OPL20930.1 - 6.5e-09 36.3 4.5 4.5e-08 33.6 1.3 2.6 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 OPL20930.1 - 9.8e-09 35.4 6.2 2e-08 34.4 1.0 2.7 2 1 1 3 3 3 1 Immunoglobulin domain ig PF00047.25 OPL20930.1 - 7.4e-05 22.8 7.3 0.029 14.6 1.2 3.3 2 2 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 OPL20930.1 - 0.00032 20.8 1.7 0.062 13.5 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain BCAS2 PF05700.11 OPL20931.1 - 1.2e-24 87.2 9.2 1.2e-24 87.1 9.2 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Methyltransf_18 PF12847.7 OPL20931.1 - 0.026 14.5 0.6 0.029 14.3 0.6 1.2 1 0 0 1 1 1 0 Methyltransferase domain Sirohm_synth_C PF14823.6 OPL20931.1 - 0.049 13.3 0.1 0.094 12.4 0.1 1.5 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal YejG PF13989.6 OPL20931.1 - 0.077 13.4 0.5 0.15 12.5 0.5 1.5 1 1 0 1 1 1 0 YejG-like protein SET PF00856.28 OPL20934.1 - 6.9e-23 81.9 0.0 2.3e-22 80.2 0.0 1.9 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 OPL20934.1 - 2e-18 67.0 7.5 3.6e-18 66.2 7.5 1.4 1 0 0 1 1 1 1 Pre-SET motif WD40 PF00400.32 OPL20935.1 - 0.0012 19.6 0.2 1.3 10.0 0.0 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 OPL20935.1 - 0.059 13.7 0.0 0.12 12.7 0.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain PMT_4TMC PF16192.5 OPL20936.1 - 1.8e-25 89.7 0.9 2.2e-25 89.4 0.9 1.1 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase PolC_DP2 PF03833.13 OPL20936.1 - 0.049 11.5 0.2 0.052 11.4 0.2 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 PMT_4TMC PF16192.5 OPL20937.1 - 1.5e-21 76.9 5.0 1.6e-21 76.8 5.0 1.0 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase Ig_3 PF13927.6 OPL20938.1 - 1.2e-27 96.2 0.5 1.3e-13 51.3 0.0 3.2 2 1 1 3 3 3 3 Immunoglobulin domain I-set PF07679.16 OPL20938.1 - 2.6e-27 94.7 0.1 3.3e-15 55.9 0.0 3.2 2 1 1 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL20938.1 - 3.2e-17 62.6 0.5 7e-08 32.7 0.1 3.2 2 1 1 3 3 3 3 Immunoglobulin domain ig PF00047.25 OPL20938.1 - 3e-12 46.5 0.4 0.0023 18.0 0.0 4.2 2 2 1 3 3 3 3 Immunoglobulin domain V-set PF07686.17 OPL20938.1 - 3.8e-11 43.1 2.1 0.018 15.2 0.1 4.7 3 2 2 5 5 5 2 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.11 OPL20938.1 - 1.8e-05 24.6 0.1 0.025 14.5 0.0 2.7 2 0 0 2 2 2 2 Ig-like C2-type domain C2-set_2 PF08205.12 OPL20938.1 - 4.2e-05 23.5 0.0 0.0023 18.0 0.0 2.9 2 1 1 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 OPL20938.1 - 0.0074 16.7 0.2 0.047 14.1 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_5 PF16681.5 OPL20938.1 - 0.0075 16.7 0.0 0.13 12.7 0.0 2.7 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 OPL20938.1 - 0.031 14.5 0.1 1.8 8.9 0.0 2.5 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 OPL20938.1 - 0.042 13.9 0.1 1.7 8.8 0.0 2.9 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain MORN_2 PF07661.13 OPL20938.1 - 0.12 12.6 0.0 1.2 9.5 0.0 2.4 2 0 0 2 2 2 0 MORN repeat variant Cornifin PF02389.15 OPL20939.1 - 1.7e-11 44.5 0.0 0.0079 16.4 0.0 4.3 1 1 2 4 4 4 4 Cornifin (SPRR) family Serine_protease PF18405.1 OPL20939.1 - 3.2e-05 23.2 19.5 0.68 9.0 0.1 7.0 1 1 2 7 7 7 4 Gammaproteobacterial serine protease Ank_2 PF12796.7 OPL20940.1 - 5.3e-22 78.2 3.8 7.5e-14 52.1 0.4 4.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL20940.1 - 8.4e-20 70.9 3.0 5.5e-07 30.0 0.4 4.6 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL20940.1 - 7.2e-17 59.8 2.6 0.015 15.7 0.1 6.7 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 OPL20940.1 - 2.9e-16 59.1 2.0 0.0048 17.3 0.0 5.9 5 1 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 OPL20940.1 - 3.5e-15 55.9 0.5 2.3e-06 27.7 0.0 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) SOCS_box PF07525.16 OPL20940.1 - 1.8e-07 31.4 0.0 4.2e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 SOCS box I-set PF07679.16 OPL20942.1 - 1.8e-18 66.4 1.9 1.3e-11 44.4 0.0 4.2 4 1 1 5 5 5 2 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL20942.1 - 2.3e-16 60.2 8.6 2.4e-09 37.7 0.2 3.3 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 OPL20942.1 - 4.4e-13 49.4 10.1 3.4e-08 33.7 0.2 3.3 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 OPL20942.1 - 3.4e-07 30.3 6.4 0.0064 16.6 0.2 3.4 4 1 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 OPL20942.1 - 4.4e-06 26.8 6.7 0.0027 17.9 0.1 3.4 3 3 2 5 5 5 2 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL20942.1 - 1.5e-05 24.5 0.1 0.28 10.8 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain V-set_CD47 PF08204.11 OPL20942.1 - 1.9 8.5 7.0 0.93 9.5 0.2 3.0 3 1 0 3 3 3 0 CD47 immunoglobulin-like domain Ldh_2 PF02615.14 OPL20943.1 - 2.8e-27 95.8 0.0 3.1e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase bZIP_2 PF07716.15 OPL20944.1 - 0.086 12.9 0.2 0.086 12.9 0.2 6.0 5 1 1 6 6 6 0 Basic region leucine zipper KASH_CCD PF14662.6 OPL20944.1 - 0.81 9.5 60.5 0.065 13.1 28.6 4.8 1 1 3 4 4 4 0 Coiled-coil region of CCDC155 or KASH Cadherin PF00028.17 OPL20947.1 - 5.7e-28 97.2 16.2 1.1e-08 35.4 2.0 5.1 5 1 0 5 5 5 4 Cadherin domain Cadherin_4 PF17803.1 OPL20947.1 - 0.00014 22.4 4.6 0.00014 22.4 4.6 5.2 4 2 1 5 5 5 3 Bacterial cadherin-like domain RET_CLD1 PF17756.1 OPL20947.1 - 0.0051 17.1 0.0 2.6 8.4 0.0 2.4 2 0 0 2 2 2 2 RET Cadherin like domain 1 Flavi_glycop_C PF02832.16 OPL20947.1 - 0.11 12.7 0.2 0.11 12.7 0.2 2.5 2 2 1 3 3 3 0 Flavivirus glycoprotein, immunoglobulin-like domain CUB PF00431.20 OPL20950.1 - 1.4e-21 76.9 0.0 4.2e-13 49.6 0.0 2.3 2 0 0 2 2 2 2 CUB domain Sushi PF00084.20 OPL20950.1 - 9.2e-09 35.8 12.8 2.7e-06 27.9 1.1 3.0 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) PAN_2 PF08276.11 OPL20950.1 - 0.0077 16.3 2.3 0.015 15.4 2.3 1.5 1 0 0 1 1 1 1 PAN-like domain PAN_1 PF00024.26 OPL20950.1 - 0.043 13.8 10.6 0.047 13.7 8.7 2.0 2 0 0 2 2 2 0 PAN domain PAN_4 PF14295.6 OPL20950.1 - 0.067 13.1 8.7 0.098 12.6 4.9 2.6 2 0 0 2 2 2 0 PAN domain MLANA PF14991.6 OPL20951.1 - 0.035 14.4 0.0 0.058 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein melan-A Vpu PF00558.19 OPL20951.1 - 0.052 13.3 0.2 0.097 12.5 0.2 1.4 1 0 0 1 1 1 0 Vpu protein adh_short PF00106.25 OPL20952.1 - 1.5e-28 99.6 0.0 2e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL20952.1 - 3.3e-18 66.1 0.0 3.9e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 OPL20952.1 - 1.7e-10 41.1 0.0 2.2e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 OPL20952.1 - 6e-05 22.6 0.1 0.00013 21.4 0.1 1.5 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 OPL20952.1 - 0.018 14.5 0.0 0.078 12.4 0.0 1.8 1 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase AdoHcyase_NAD PF00670.21 OPL20952.1 - 0.029 14.4 0.4 0.048 13.7 0.4 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Epimerase PF01370.21 OPL20952.1 - 0.03 13.8 0.0 0.034 13.6 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family HEAT PF02985.22 OPL20953.1 - 9.5e-08 31.7 0.3 0.011 16.0 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat Cnd1 PF12717.7 OPL20953.1 - 1.5e-05 25.1 0.5 1.5e-05 25.1 0.5 3.1 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 OPL20953.1 - 0.00076 19.8 0.0 0.023 15.1 0.0 2.7 1 1 0 1 1 1 1 HEAT repeats Adaptin_N PF01602.20 OPL20953.1 - 0.0011 17.7 0.2 0.002 16.8 0.2 1.5 1 0 0 1 1 1 1 Adaptin N terminal region Cas9_a PF18470.1 OPL20953.1 - 0.096 12.2 0.2 0.2 11.2 0.2 1.5 1 0 0 1 1 1 0 Cas9 alpha-helical lobe domain Usp PF00582.26 OPL20954.1 - 3e-17 63.5 0.0 3.5e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Acyl-CoA_dh_1 PF00441.24 OPL20955.1 - 0.00068 19.9 0.9 0.0019 18.4 0.9 1.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF1980 PF09323.10 OPL20955.1 - 0.099 12.6 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) GFA PF04828.14 OPL20956.1 - 0.00014 22.1 0.1 0.00015 22.0 0.1 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Ribosomal_L37e PF01907.19 OPL20956.1 - 0.015 15.4 0.3 0.027 14.6 0.3 1.4 1 0 0 1 1 1 0 Ribosomal protein L37e Vps36-NZF-N PF16988.5 OPL20956.1 - 0.047 13.1 0.3 0.11 11.9 0.1 1.7 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Claudin_2 PF13903.6 OPL20958.1 - 0.00045 20.0 10.9 0.068 12.9 10.2 2.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Fig1 PF12351.8 OPL20958.1 - 0.017 15.0 1.1 0.017 15.0 1.1 2.1 3 0 0 3 3 3 0 Ca2+ regulator and membrane fusion protein Fig1 Clc-like PF07062.12 OPL20958.1 - 1.1 8.7 9.5 12 5.3 6.4 2.2 1 1 1 2 2 2 0 Clc-like DUF3951 PF13131.6 OPL20958.1 - 1.2 9.3 10.7 0.75 10.0 0.9 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3951) DUF4199 PF13858.6 OPL20958.1 - 9.7 6.6 13.8 0.78 10.1 7.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) GRIP PF01465.20 OPL20959.1 - 1.3e-15 57.0 0.2 2.4e-15 56.1 0.2 1.5 1 0 0 1 1 1 1 GRIP domain Tropomyosin_1 PF12718.7 OPL20959.1 - 4.1e-05 23.8 18.7 7.4e-05 22.9 18.7 1.5 1 0 0 1 1 1 1 Tropomyosin like TMF_TATA_bd PF12325.8 OPL20959.1 - 0.00091 19.4 17.1 0.0027 17.9 17.1 1.8 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding TPR_MLP1_2 PF07926.12 OPL20959.1 - 0.0011 19.0 20.3 0.002 18.2 20.3 1.4 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein UPF0242 PF06785.11 OPL20959.1 - 0.0013 18.8 19.7 0.0024 18.0 19.7 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus NPV_P10 PF05531.12 OPL20959.1 - 0.0026 18.2 18.3 0.068 13.6 6.7 2.3 1 1 1 2 2 2 2 Nucleopolyhedrovirus P10 protein GAS PF13851.6 OPL20959.1 - 0.0038 16.6 21.3 0.029 13.7 20.7 2.0 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding HAUS5 PF14817.6 OPL20959.1 - 0.005 15.7 7.1 0.0054 15.6 7.1 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 Med30 PF11315.8 OPL20959.1 - 0.0073 16.5 13.5 0.018 15.3 13.5 1.6 1 0 0 1 1 1 1 Mediator complex subunit 30 APG6_N PF17675.1 OPL20959.1 - 0.008 16.7 17.2 0.015 15.8 17.2 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region AAA_13 PF13166.6 OPL20959.1 - 0.016 13.9 15.5 0.029 13.1 15.5 1.3 1 0 0 1 1 1 0 AAA domain Lebercilin PF15619.6 OPL20959.1 - 0.016 14.9 20.3 0.026 14.2 19.7 1.7 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.11 OPL20959.1 - 0.023 13.6 23.5 0.022 13.6 10.2 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein MscS_porin PF12795.7 OPL20959.1 - 0.028 14.0 19.4 0.043 13.3 19.4 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF745 PF05335.13 OPL20959.1 - 0.038 13.7 11.8 0.058 13.1 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) SlyX PF04102.12 OPL20959.1 - 0.044 14.4 17.1 1.8 9.3 2.7 2.6 1 1 1 2 2 2 0 SlyX MPS2 PF17060.5 OPL20959.1 - 0.056 12.7 14.5 0.16 11.2 7.5 2.1 1 1 1 2 2 2 0 Monopolar spindle protein 2 FPP PF05911.11 OPL20959.1 - 0.059 11.6 19.2 0.11 10.6 19.2 1.4 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF4407 PF14362.6 OPL20959.1 - 0.079 12.3 15.1 0.64 9.3 15.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) MAD PF05557.13 OPL20959.1 - 0.085 11.2 21.4 0.14 10.5 21.4 1.3 1 0 0 1 1 1 0 Mitotic checkpoint protein Phage_GP20 PF06810.11 OPL20959.1 - 0.11 12.3 18.6 0.6 9.9 18.6 2.1 1 1 0 1 1 1 0 Phage minor structural protein GP20 ADIP PF11559.8 OPL20959.1 - 0.13 12.3 23.8 1.7 8.7 8.0 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding HrpB7 PF09486.10 OPL20959.1 - 0.13 12.6 8.0 1.3 9.4 0.2 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Snapin_Pallidin PF14712.6 OPL20959.1 - 0.15 12.5 15.8 0.42 11.1 14.7 2.3 1 1 0 1 1 1 0 Snapin/Pallidin ATG16 PF08614.11 OPL20959.1 - 0.15 12.2 23.1 5.3 7.2 23.1 2.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Mod_r PF07200.13 OPL20959.1 - 0.19 11.8 21.6 0.23 11.6 4.0 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Seryl_tRNA_N PF02403.22 OPL20959.1 - 0.27 11.5 15.2 0.56 10.5 15.2 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Phage_GPO PF05929.11 OPL20959.1 - 0.28 10.8 12.3 0.45 10.1 12.3 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase V_ATPase_I PF01496.19 OPL20959.1 - 0.31 8.9 7.6 0.37 8.6 7.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3450 PF11932.8 OPL20959.1 - 0.31 10.3 16.9 0.51 9.6 16.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CENP-Q PF13094.6 OPL20959.1 - 0.33 11.1 20.1 0.28 11.4 11.9 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4795 PF16043.5 OPL20959.1 - 0.43 10.1 22.0 9.4 5.8 21.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) T3SSipB PF16535.5 OPL20959.1 - 0.5 10.8 11.6 1.3 9.4 11.6 1.6 1 1 1 2 2 2 0 Type III cell invasion protein SipB TMF_DNA_bd PF12329.8 OPL20959.1 - 0.5 10.4 27.4 3.5 7.7 9.2 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF148 PF02520.17 OPL20959.1 - 0.53 10.4 17.0 1.3 9.2 16.6 1.8 1 1 1 2 2 2 0 Domain of unknown function DUF148 FlaC_arch PF05377.11 OPL20959.1 - 0.53 10.7 11.7 2.3 8.6 4.3 3.2 1 1 2 3 3 2 0 Flagella accessory protein C (FlaC) Golgin_A5 PF09787.9 OPL20959.1 - 0.71 9.3 18.2 1.2 8.5 18.2 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF1845 PF08900.11 OPL20959.1 - 0.74 9.5 5.4 0.1 12.3 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1845) Herpes_UL6 PF01763.16 OPL20959.1 - 0.75 8.2 12.0 1.1 7.7 12.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like Prefoldin_2 PF01920.20 OPL20959.1 - 0.77 9.8 19.7 1.9 8.5 3.0 2.5 1 1 1 2 2 2 0 Prefoldin subunit CP12 PF02672.15 OPL20959.1 - 0.77 10.6 7.3 0.58 10.9 4.5 2.2 1 1 1 2 2 1 0 CP12 domain FapA PF03961.13 OPL20959.1 - 0.78 8.3 13.9 1.2 7.7 13.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF16 PF01519.16 OPL20959.1 - 0.8 10.2 19.7 12 6.5 8.4 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 Gp58 PF07902.11 OPL20959.1 - 0.84 7.9 11.6 5.4 5.2 11.6 1.9 1 1 0 1 1 1 0 gp58-like protein Nup54 PF13874.6 OPL20959.1 - 1.1 9.4 11.5 0.74 9.9 9.7 1.6 2 0 0 2 2 1 0 Nucleoporin complex subunit 54 DUF3584 PF12128.8 OPL20959.1 - 1.1 6.7 19.3 2.3 5.6 19.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF812 PF05667.11 OPL20959.1 - 1.2 7.9 18.3 1.8 7.3 18.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) BLOC1_2 PF10046.9 OPL20959.1 - 1.5 9.1 16.6 5.1 7.5 4.9 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Csm1_N PF18504.1 OPL20959.1 - 1.6 9.2 18.9 2 8.8 7.6 2.9 1 1 2 3 3 3 0 Csm1 N-terminal domain BST2 PF16716.5 OPL20959.1 - 1.6 9.3 22.7 0.52 10.9 13.0 3.0 2 1 1 3 3 2 0 Bone marrow stromal antigen 2 DUF2779 PF11074.8 OPL20959.1 - 1.7 9.1 5.9 0.83 10.1 3.0 1.9 2 0 0 2 2 2 0 Domain of unknown function(DUF2779) Cnn_1N PF07989.11 OPL20959.1 - 1.7 8.9 20.1 14 6.0 15.6 3.7 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Jnk-SapK_ap_N PF09744.9 OPL20959.1 - 1.8 8.8 21.8 5.5 7.2 21.8 1.8 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 OPL20959.1 - 1.8 8.3 13.8 5.5 6.8 13.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Fib_alpha PF08702.10 OPL20959.1 - 2 8.6 19.9 0.53 10.5 14.9 2.3 2 1 1 3 3 2 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 OPL20959.1 - 2 8.2 22.0 0.075 12.8 1.3 3.6 1 1 2 3 3 3 0 Septum formation initiator FliD_C PF07195.12 OPL20959.1 - 2.4 7.5 16.0 75 2.6 16.0 2.3 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus CC2-LZ PF16516.5 OPL20959.1 - 3.2 8.2 17.5 8.2 6.9 7.2 2.7 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Spectrin PF00435.21 OPL20959.1 - 3.3 8.3 17.7 17 5.9 13.5 2.4 1 1 1 2 2 2 0 Spectrin repeat VSG_B PF13206.6 OPL20959.1 - 3.3 6.9 9.8 4.4 6.5 9.8 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain DUF3958 PF13125.6 OPL20959.1 - 3.5 7.9 18.8 1.6 9.0 5.8 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3958) Exonuc_VII_L PF02601.15 OPL20959.1 - 4.7 6.7 16.6 5.8 6.4 16.2 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit DASH_Dam1 PF08653.10 OPL20959.1 - 4.7 7.1 10.4 9 6.2 1.2 3.3 2 1 1 3 3 3 0 DASH complex subunit Dam1 OmpH PF03938.14 OPL20959.1 - 4.8 7.5 18.4 10 6.5 18.4 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF641 PF04859.12 OPL20959.1 - 5.6 7.3 17.2 0.42 11.0 1.7 2.7 2 1 1 3 3 2 0 Plant protein of unknown function (DUF641) Atg14 PF10186.9 OPL20959.1 - 5.7 5.9 19.6 9.9 5.1 19.2 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 KLRAQ PF10205.9 OPL20959.1 - 6.1 7.1 19.7 2.5 8.4 5.2 3.1 1 1 2 3 3 2 0 Predicted coiled-coil domain-containing protein DUF1664 PF07889.12 OPL20959.1 - 6.3 6.9 15.0 2 8.5 4.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FAM76 PF16046.5 OPL20959.1 - 6.7 6.0 18.9 0.56 9.5 13.9 1.7 2 0 0 2 2 2 0 FAM76 protein p450 PF00067.22 OPL20960.1 - 8e-51 173.2 0.1 8.7e-51 173.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 COR PF16095.5 OPL20961.1 - 2.1e-11 44.0 0.1 3.6e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain HAS-barrel PF09378.10 OPL20962.1 - 2 8.6 0.0 2 8.6 0.0 4.2 1 1 1 3 3 3 0 HAS barrel domain Macro PF01661.21 OPL20963.1 - 1.7e-08 34.5 0.0 2e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Macro domain Coagulin PF02035.15 OPL20963.1 - 0.068 13.1 0.0 0.096 12.6 0.0 1.2 1 0 0 1 1 1 0 Coagulin WD40 PF00400.32 OPL20964.1 - 7e-14 52.0 9.1 1.4e-05 25.7 0.1 3.4 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 OPL20964.1 - 0.0003 19.6 3.6 0.0056 15.4 0.4 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 OPL20964.1 - 0.00047 20.1 0.1 0.001 19.0 0.1 1.5 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 OPL20964.1 - 0.0017 18.6 0.5 0.011 16.0 0.7 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 OPL20964.1 - 0.0037 16.3 0.2 0.12 11.3 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein REJ PF02010.15 OPL20965.1 - 1.2e-17 63.9 3.8 1.7e-17 63.4 0.1 2.0 1 1 1 2 2 2 2 REJ domain Syntaxin PF00804.25 OPL20966.1 - 0.0011 18.7 5.3 0.0012 18.5 5.3 1.1 1 0 0 1 1 1 1 Syntaxin NPV_P10 PF05531.12 OPL20966.1 - 0.0047 17.3 7.3 0.0077 16.7 7.2 1.5 1 1 0 1 1 1 1 Nucleopolyhedrovirus P10 protein DUF4763 PF15960.5 OPL20966.1 - 0.034 13.5 5.1 0.036 13.4 5.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Tweety PF04906.13 OPL20966.1 - 0.1 11.3 2.4 0.12 11.0 2.4 1.1 1 0 0 1 1 1 0 Tweety SKA1 PF07160.12 OPL20966.1 - 0.12 12.2 5.7 0.12 12.2 5.7 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF2232 PF09991.9 OPL20966.1 - 0.36 10.0 1.0 0.36 10.0 1.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) FlaC_arch PF05377.11 OPL20966.1 - 0.57 10.6 6.6 4.9 7.6 0.8 2.3 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) AI-2E_transport PF01594.16 OPL20966.1 - 0.68 9.0 1.6 0.8 8.8 1.6 1.0 1 0 0 1 1 1 0 AI-2E family transporter Anemone_cytotox PF06369.12 OPL20967.1 - 0.0039 16.8 1.0 0.0077 15.9 0.6 1.4 1 1 0 1 1 1 1 Sea anemone cytotoxic protein Sorb PF02208.16 OPL20967.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Sorbin homologous domain PG_binding_2 PF08823.11 OPL20969.1 - 0.0029 17.9 0.1 0.048 14.0 0.0 2.3 2 0 0 2 2 2 1 Putative peptidoglycan binding domain LEM PF03020.15 OPL20969.1 - 0.069 12.7 0.1 0.71 9.5 0.0 2.4 2 0 0 2 2 2 0 LEM domain TPT PF03151.16 OPL20970.1 - 1.3e-05 24.7 2.1 1.7e-05 24.4 2.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 OPL20970.1 - 7e-05 22.2 1.2 9e-05 21.8 1.2 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 OPL20970.1 - 0.22 11.7 3.4 0.26 11.5 3.4 1.1 1 0 0 1 1 1 0 EamA-like transporter family ABC2_membrane PF01061.24 OPL20971.1 - 0.64 9.4 7.2 0.17 11.3 1.4 2.0 2 0 0 2 2 2 0 ABC-2 type transporter AIG1 PF04548.16 OPL20972.1 - 3e-67 226.0 2.1 3.1e-67 226.0 1.3 1.4 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 OPL20972.1 - 2.1e-06 27.8 0.1 2.1e-06 27.8 0.1 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 OPL20972.1 - 0.002 17.7 0.1 0.002 17.7 0.1 2.1 2 1 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 OPL20972.1 - 0.023 14.6 1.3 0.041 13.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 OPL20972.1 - 0.035 13.6 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 OPL20972.1 - 0.045 14.0 0.0 0.15 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 OPL20972.1 - 0.062 13.4 0.0 0.062 13.4 0.0 2.4 2 1 0 2 2 2 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 OPL20972.1 - 0.11 11.8 0.2 1.5 8.2 0.0 2.3 2 1 0 2 2 2 0 FtsK/SpoIIIE family AAA_29 PF13555.6 OPL20972.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 OPL20972.1 - 0.14 12.1 0.5 14 5.6 0.0 2.3 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 OPL20972.1 - 0.57 10.2 11.3 1.5 8.9 0.0 3.6 2 2 1 3 3 3 0 Dynamin family DUF2992 PF11208.8 OPL20972.1 - 1.5 9.0 11.3 2.8 8.2 11.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) AAA_23 PF13476.6 OPL20972.1 - 8.1 6.9 20.4 4.4 7.8 13.6 2.2 2 0 0 2 2 2 0 AAA domain DNA_ligase_A_C PF04679.15 OPL20973.1 - 5.5e-18 65.4 0.0 1.4e-17 64.1 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region LIG3_BRCT PF16759.5 OPL20973.1 - 4.1e-05 23.8 0.0 9.1e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain DTHCT PF08070.11 OPL20973.1 - 0.041 14.6 27.1 0.12 13.1 11.7 2.7 1 1 0 2 2 2 0 DTHCT (NUC029) region Rhomboid PF01694.22 OPL20974.1 - 1.3e-14 54.5 1.5 1.8e-14 54.0 0.5 1.6 2 0 0 2 2 2 1 Rhomboid family C1q PF00386.21 OPL20975.1 - 7.2e-14 52.1 1.1 8.8e-14 51.8 0.1 1.7 2 0 0 2 2 2 1 C1q domain FapA PF03961.13 OPL20975.1 - 0.00016 20.4 1.6 0.00021 20.0 1.6 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A FliT PF05400.13 OPL20975.1 - 0.002 18.9 2.3 0.0031 18.3 2.3 1.2 1 0 0 1 1 1 1 Flagellar protein FliT YkyA PF10368.9 OPL20975.1 - 0.0053 16.4 5.0 0.0089 15.7 5.0 1.3 1 0 0 1 1 1 1 Putative cell-wall binding lipoprotein V-ATPase_G PF03179.15 OPL20975.1 - 0.016 15.7 5.3 0.028 15.0 5.3 1.3 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit DUF2046 PF09755.9 OPL20975.1 - 0.029 13.6 4.2 0.046 12.9 3.4 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) ApoO PF09769.9 OPL20975.1 - 0.031 14.2 0.6 0.049 13.6 0.6 1.2 1 0 0 1 1 1 0 Apolipoprotein O ADIP PF11559.8 OPL20975.1 - 0.036 14.2 7.0 0.053 13.6 7.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding NPV_P10 PF05531.12 OPL20975.1 - 0.063 13.8 0.8 5.4 7.6 0.2 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.6 OPL20975.1 - 0.066 13.6 10.3 0.12 12.8 2.4 2.3 1 1 1 2 2 2 0 Snapin/Pallidin BclA_C PF18573.1 OPL20975.1 - 0.068 13.1 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 BclA C-terminal domain DivIC PF04977.15 OPL20975.1 - 0.11 12.3 2.4 6.9 6.5 0.2 2.5 2 0 0 2 2 2 0 Septum formation initiator UPF0449 PF15136.6 OPL20975.1 - 0.12 12.9 1.1 0.19 12.2 1.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 APG6_N PF17675.1 OPL20975.1 - 0.18 12.3 4.8 0.28 11.7 4.8 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region FadA PF09403.10 OPL20975.1 - 0.3 11.6 7.4 0.54 10.8 7.4 1.4 1 0 0 1 1 1 0 Adhesion protein FadA Atg14 PF10186.9 OPL20975.1 - 0.4 9.7 5.9 0.57 9.2 5.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 OPL20975.1 - 0.57 9.4 3.9 0.82 8.9 3.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein XhlA PF10779.9 OPL20975.1 - 0.8 10.0 4.8 0.81 9.9 0.4 2.2 1 1 1 2 2 2 0 Haemolysin XhlA CCDC-167 PF15188.6 OPL20975.1 - 1 9.7 5.1 2 8.8 5.1 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Cep57_CLD_2 PF14197.6 OPL20975.1 - 1.7 8.8 6.0 2.7 8.1 0.7 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Lig_chan-Glu_bd PF10613.9 OPL20976.1 - 3.5e-14 53.0 0.0 3.8e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 OPL20976.1 - 4.4e-05 23.0 0.0 4.8e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 UCH_C PF18031.1 OPL20976.1 - 0.01 15.7 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolases CH PF00307.31 OPL20977.1 - 7.2e-05 22.9 0.2 0.0001 22.4 0.2 1.5 1 1 0 1 1 1 1 Calponin homology (CH) domain DAGK_acc PF00609.19 OPL20978.1 - 2.3e-34 119.0 0.1 4.9e-34 118.0 0.0 1.5 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain DAO PF01266.24 OPL20979.1 - 1.2e-18 67.9 0.0 1.5e-18 67.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Ras PF00071.22 OPL20980.1 - 7.9e-25 87.3 0.4 1.1e-24 86.9 0.4 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL20980.1 - 0.00021 21.5 0.1 0.00047 20.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 OPL20980.1 - 0.012 15.4 0.5 0.77 9.5 0.3 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 OPL20980.1 - 0.026 14.1 0.3 0.03 13.9 0.3 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Y_phosphatase PF00102.27 OPL20981.1 - 2e-36 125.7 0.0 3e-36 125.2 0.0 1.3 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 OPL20981.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain C1q PF00386.21 OPL20982.1 - 2.9e-19 69.5 0.2 3.5e-19 69.3 0.2 1.1 1 0 0 1 1 1 1 C1q domain OCRE PF17780.1 OPL20982.1 - 0.042 13.9 0.2 0.078 13.0 0.2 1.4 1 0 0 1 1 1 0 OCRE domain RBD PF02196.15 OPL20982.1 - 0.11 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Raf-like Ras-binding domain LRR_6 PF13516.6 OPL20983.1 - 0.00044 20.1 5.3 2.7 8.3 0.2 5.6 5 1 0 5 5 5 1 Leucine Rich repeat LRR_1 PF00560.33 OPL20983.1 - 0.033 14.7 2.5 8.9 7.3 0.1 4.6 4 2 0 4 4 4 0 Leucine Rich Repeat LRR_4 PF12799.7 OPL20983.1 - 0.075 13.5 1.0 21 5.7 0.1 3.5 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Motile_Sperm PF00635.26 OPL20984.1 - 3.9e-23 81.4 0.0 7.1e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CSG2 PF16965.5 OPL20984.1 - 0.00062 18.8 0.2 0.00096 18.2 0.2 1.2 1 0 0 1 1 1 1 Ceramide synthase regulator Orf78 PF06024.12 OPL20984.1 - 0.0016 18.7 0.4 0.0043 17.3 0.1 1.8 2 0 0 2 2 2 1 Orf78 (ac78) DUF4391 PF14335.6 OPL20984.1 - 0.022 14.4 0.2 0.029 14.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) UPF0184 PF03670.13 OPL20984.1 - 0.052 13.9 0.5 0.099 13.0 0.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) DUF2207 PF09972.9 OPL20984.1 - 0.068 11.9 0.6 0.62 8.8 0.6 2.1 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5362 PF17319.2 OPL20984.1 - 4 7.3 7.9 0.12 12.2 1.5 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5362) MFS_1 PF07690.16 OPL20985.1 - 2.2e-18 66.3 4.4 2.5e-18 66.1 4.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 OPL20985.1 - 7.2e-09 35.0 1.9 7.3e-09 35.0 1.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Death PF00531.22 OPL20986.1 - 1.7e-05 24.9 0.0 4.2e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Death domain Trypsin_2 PF13365.6 OPL20986.1 - 8.5e-05 23.5 0.0 0.00026 21.9 0.0 1.8 1 0 0 1 1 1 1 Trypsin-like peptidase domain Laminin_G_2 PF02210.24 OPL20987.1 - 7.6e-22 78.2 1.2 4.8e-13 49.8 0.1 2.2 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 OPL20987.1 - 8.1e-15 55.2 0.1 4.9e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 OPL20987.1 - 0.002 18.4 5.4 0.0055 17.0 5.4 1.8 1 0 0 1 1 1 1 EGF-like domain Fibrinogen_C PF00147.18 OPL20987.1 - 0.0077 16.1 0.2 0.015 15.1 0.2 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF11 PF01345.18 OPL20988.1 - 0.012 15.9 0.2 0.019 15.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF11 Usp PF00582.26 OPL20989.1 - 4.5e-18 66.1 0.0 6.9e-18 65.5 0.0 1.3 1 1 0 1 1 1 1 Universal stress protein family DAGK_cat PF00781.24 OPL20989.1 - 0.077 12.6 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF3798 PF12683.7 OPL20989.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3798) Octopine_DH PF02317.17 OPL20990.1 - 4.4e-33 114.5 0.1 6.6e-33 113.9 0.1 1.2 1 0 0 1 1 1 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain GOLD_2 PF13897.6 OPL20991.1 - 2.4e-12 47.5 0.5 6.4e-07 29.9 0.1 2.2 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO PF00650.20 OPL20991.1 - 2e-09 37.4 0.0 3e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain EMP24_GP25L PF01105.24 OPL20991.1 - 0.0078 16.2 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD MFS_1 PF07690.16 OPL20992.1 - 2.2e-25 89.4 9.1 6.1e-14 51.7 10.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 OPL20992.1 - 0.0021 17.4 2.4 0.0021 17.4 2.4 1.6 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 OPL20992.1 - 0.012 13.9 0.5 0.02 13.2 0.3 1.5 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family LacY_symp PF01306.19 OPL20992.1 - 0.77 8.5 9.5 0.13 11.0 4.8 2.0 2 1 0 3 3 3 0 LacY proton/sugar symporter Thioredoxin PF00085.20 OPL20994.1 - 6.1e-07 29.4 0.0 1.3e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 OPL20994.1 - 0.042 14.3 4.4 3.4 8.2 0.6 3.9 3 1 0 3 3 3 0 Thioredoxin-like domain Lectin_C PF00059.21 OPL20996.1 - 7.7e-11 42.7 0.2 1.1e-10 42.2 0.2 1.2 1 0 0 1 1 1 1 Lectin C-type domain ApeC PF16977.5 OPL20997.1 - 2.5e-64 217.0 2.0 2.8e-64 216.8 2.0 1.0 1 0 0 1 1 1 1 C-terminal domain of apextrin Roc PF08477.13 OPL20999.1 - 4.3e-17 62.4 1.0 3.1e-10 40.3 0.1 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL20999.1 - 1.2e-06 28.2 0.2 0.019 14.5 0.0 2.3 2 0 0 2 2 2 2 Ras family Arf PF00025.21 OPL20999.1 - 4.2e-06 26.3 0.1 9.8e-06 25.1 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 OPL20999.1 - 0.0001 22.4 0.1 0.0035 17.4 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 OPL20999.1 - 0.001 19.6 0.4 0.0021 18.6 0.4 1.5 1 1 0 1 1 1 1 ABC transporter Dynamin_N PF00350.23 OPL20999.1 - 0.0011 19.1 0.1 0.0025 17.9 0.1 1.6 1 1 0 1 1 1 1 Dynamin family AAA_22 PF13401.6 OPL20999.1 - 0.0025 18.1 0.0 0.0054 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 OPL20999.1 - 0.0036 16.6 0.0 0.0058 16.0 0.0 1.4 1 0 0 1 1 1 1 Septin AAA_16 PF13191.6 OPL20999.1 - 0.0048 17.3 0.3 0.0074 16.7 0.3 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 OPL20999.1 - 0.0062 16.1 0.0 0.3 10.6 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region Gtr1_RagA PF04670.12 OPL20999.1 - 0.016 14.6 0.2 0.96 8.7 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 OPL20999.1 - 0.024 14.4 0.0 0.065 13.0 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 OPL20999.1 - 0.031 14.2 0.1 0.073 13.0 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase DUF4298 PF14131.6 OPL20999.1 - 0.063 13.2 0.1 0.41 10.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) TniB PF05621.11 OPL20999.1 - 0.069 12.5 0.0 0.45 9.9 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA PF00004.29 OPL20999.1 - 0.09 13.2 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 OPL20999.1 - 0.12 12.4 0.1 0.29 11.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 OPL20999.1 - 0.14 12.7 0.4 0.5 10.9 0.4 2.1 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 OPL20999.1 - 0.18 12.0 1.3 0.33 11.1 0.6 1.9 2 1 0 2 2 2 0 AAA domain LRAT PF04970.13 OPL21000.1 - 7.8e-06 26.2 1.4 0.12 12.7 0.2 2.3 2 0 0 2 2 2 2 Lecithin retinol acyltransferase DUF2187 PF09953.9 OPL21000.1 - 0.025 14.6 0.1 7.9 6.6 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2187) CDC48_2 PF02933.17 OPL21000.1 - 0.11 12.3 0.0 4 7.3 0.0 2.4 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 Bud13 PF09736.9 OPL21001.1 - 7.1e-46 156.2 12.8 7.1e-46 156.2 12.8 3.3 2 1 1 3 3 3 1 Pre-mRNA-splicing factor of RES complex Metallophos PF00149.28 OPL21002.1 - 0.0003 21.3 0.1 0.00036 21.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF2779 PF11074.8 OPL21005.1 - 0.059 13.8 0.1 0.087 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function(DUF2779) Sugar_tr PF00083.24 OPL21006.1 - 5e-05 22.3 0.0 5.7e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Pkip-1 PF06878.11 OPL21006.1 - 0.041 14.0 0.6 0.047 13.8 0.6 1.2 1 0 0 1 1 1 0 Pkip-1 protein TRAPPC9-Trs120 PF08626.11 OPL21007.1 - 2.9e-08 31.6 0.1 9.1e-08 30.0 0.1 1.6 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF4105 PF13387.6 OPL21008.1 - 0.0033 17.1 0.7 0.0059 16.2 0.6 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4105) W2 PF02020.18 OPL21008.1 - 0.042 14.0 0.3 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 eIF4-gamma/eIF5/eIF2-epsilon Viral_DNA_Zn_bi PF03728.13 OPL21008.1 - 0.13 12.8 0.0 0.23 12.1 0.0 1.3 1 0 0 1 1 1 0 Viral DNA-binding protein, zinc binding domain WD40 PF00400.32 OPL21009.1 - 3e-08 34.2 0.1 0.15 12.9 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ADH_zinc_N PF00107.26 OPL21010.1 - 3.3e-25 88.5 0.1 6.7e-25 87.6 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 OPL21010.1 - 8.2e-24 83.6 5.7 1.4e-23 82.8 5.7 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 OPL21010.1 - 1.9e-07 30.8 0.1 2.7e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Methyltransf_25 PF13649.6 OPL21010.1 - 0.0018 18.9 0.0 0.016 15.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain ADH_N_2 PF16884.5 OPL21010.1 - 0.0053 16.6 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 OPL21010.1 - 0.01 16.9 0.0 0.017 16.1 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase MTS PF05175.14 OPL21010.1 - 0.024 14.2 0.1 2.1 7.9 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_11 PF08241.12 OPL21010.1 - 0.069 13.8 0.0 0.22 12.2 0.0 1.9 2 0 0 2 2 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 OPL21010.1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 OPL21010.1 - 0.11 11.8 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PrmA PF06325.13 OPL21010.1 - 0.11 11.9 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Otopetrin PF03189.13 OPL21011.1 - 1.1e-38 133.2 16.0 8.2e-21 74.3 3.0 3.0 1 1 1 2 2 2 2 Otopetrin Gly_transf_sug PF04488.15 OPL21011.1 - 0.11 13.1 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase sugar-binding region containing DXD motif RBD PF02196.15 OPL21012.1 - 3.3e-17 62.3 0.0 5.8e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Raf-like Ras-binding domain DUF848 PF05852.11 OPL21012.1 - 0.0035 17.4 0.2 0.0067 16.6 0.1 1.5 2 0 0 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) RVT_1 PF00078.27 OPL21013.1 - 9.3e-12 44.9 0.0 1.1e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ZNRF_3_ecto PF18212.1 OPL21013.1 - 0.12 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 ZNRF-3 Ectodomain DUF2039 PF10217.9 OPL21015.1 - 1.1e-06 28.9 5.3 1.1e-06 28.9 5.3 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2039) EGF_2 PF07974.13 OPL21019.1 - 9.8 6.6 20.1 0.43 11.0 1.6 3.0 2 1 1 3 3 3 0 EGF-like domain Laminin_EGF PF00053.24 OPL21020.1 - 0.11 12.6 27.4 0.2 11.8 15.9 3.4 1 1 2 3 3 3 0 Laminin EGF domain TNFR_c6 PF00020.18 OPL21021.1 - 4.4e-18 65.4 36.3 2.2e-06 27.9 2.1 4.3 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 OPL21021.1 - 0.018 14.8 32.3 0.062 13.1 4.1 4.4 2 2 2 4 4 4 0 Putative ephrin-receptor like Ribosomal_L23eN PF03939.13 OPL21022.1 - 0.024 14.9 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L23, N-terminal domain C8 PF08742.11 OPL21022.1 - 0.031 14.7 0.2 0.031 14.7 0.2 1.8 2 0 0 2 2 2 0 C8 domain FeS_assembly_P PF01883.19 OPL21022.1 - 0.12 12.6 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Iron-sulfur cluster assembly protein TSP_1 PF00090.19 OPL21023.1 - 5e-08 33.0 12.3 5e-08 33.0 12.3 3.2 4 0 0 4 4 4 1 Thrombospondin type 1 domain Laminin_G_3 PF13385.6 OPL21023.1 - 2.4e-07 31.0 0.0 4.3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 OPL21023.1 - 4.4e-06 26.9 41.2 0.00011 22.5 13.1 3.1 3 0 0 3 3 3 2 EGF-like domain EGF PF00008.27 OPL21023.1 - 6.5e-06 26.3 30.2 0.015 15.6 10.8 3.2 2 1 0 2 2 2 2 EGF-like domain Laminin_G_2 PF02210.24 OPL21023.1 - 4.8e-05 23.9 0.0 8.3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 OPL21023.1 - 0.00081 19.9 23.0 0.025 15.2 6.4 3.1 2 0 0 2 2 2 2 Human growth factor-like EGF Laminin_G_1 PF00054.23 OPL21023.1 - 0.015 15.5 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain LRIF1 PF15741.5 OPL21023.1 - 0.018 13.6 0.8 0.023 13.2 0.8 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 UPF0767 PF15990.5 OPL21023.1 - 0.14 12.3 0.1 0.34 11.1 0.1 1.6 1 0 0 1 1 1 0 UPF0767 family Med19 PF10278.9 OPL21023.1 - 0.7 9.8 8.7 0.47 10.4 6.5 1.7 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 CUB PF00431.20 OPL21024.1 - 1.3e-11 44.8 0.1 2.2e-11 44.0 0.1 1.4 1 0 0 1 1 1 1 CUB domain Ldl_recept_a PF00057.18 OPL21024.1 - 1.6e-08 34.6 4.1 3.1e-08 33.7 4.1 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Adeno_E3_CR2 PF02439.15 OPL21024.1 - 0.0067 16.2 4.3 0.013 15.3 4.3 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Orthoreo_P10 PF07204.11 OPL21024.1 - 0.017 15.0 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 EphA2_TM PF14575.6 OPL21025.1 - 0.016 16.0 0.2 0.043 14.7 0.0 1.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain FAM163 PF15069.6 OPL21025.1 - 0.034 14.6 0.0 0.034 14.6 0.0 1.9 2 0 0 2 2 2 0 FAM163 family Shisa PF13908.6 OPL21025.1 - 0.041 14.1 8.3 0.032 14.5 6.8 1.6 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator CYYR1 PF10873.8 OPL21025.1 - 3.1 8.2 40.3 0.023 15.1 25.2 2.4 1 1 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 DNA_pol_P_Exo PF18049.1 OPL21026.1 - 0.001 18.5 1.2 0.0062 16.0 0.2 2.3 2 0 0 2 2 2 1 DNA polymerase nu pseudo-exo DUF4559 PF15112.6 OPL21027.1 - 0.025 14.3 0.9 0.11 12.2 0.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) HEPN_Swt1 PF18731.1 OPL21027.1 - 0.046 14.1 0.0 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Swt1-like HEPN HECT PF00632.25 OPL21030.1 - 7.5e-13 48.6 1.1 1.7e-12 47.5 1.1 1.5 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF2407_C PF13373.6 OPL21031.1 - 0.047 13.9 0.1 0.047 13.9 0.1 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain Glyco_transf_49 PF13896.6 OPL21033.1 - 3.9e-33 115.2 0.8 1.1e-19 71.0 0.2 2.3 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_transf_8 PF01501.20 OPL21033.1 - 1.5e-10 41.1 0.3 3.1e-10 40.0 0.3 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 8 RAP80_UIM PF18282.1 OPL21033.1 - 0.048 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 RAP80 N-terminal ubiquitin interaction motif MASE1 PF05231.14 OPL21034.1 - 0.1 11.8 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 MASE1 Ribos_L4_asso_C PF14374.6 OPL21034.1 - 0.15 12.1 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 60S ribosomal protein L4 C-terminal domain Na_H_Exchanger PF00999.21 OPL21035.1 - 3e-08 32.9 0.8 3.7e-08 32.6 0.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF1772 PF08592.11 OPL21035.1 - 0.23 11.8 0.6 0.6 10.4 0.1 1.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) PMSR PF01625.21 OPL21036.1 - 3.9e-53 179.7 1.4 4.7e-53 179.5 0.3 1.7 2 0 0 2 2 2 1 Peptide methionine sulfoxide reductase EF-hand_1 PF00036.32 OPL21037.1 - 1.2e-27 93.4 17.2 4.2e-08 32.2 1.4 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 OPL21037.1 - 1.9e-26 91.6 11.1 2.7e-12 46.4 1.5 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_7 PF13499.6 OPL21037.1 - 4.7e-26 91.0 7.8 1.1e-12 48.3 1.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 OPL21037.1 - 3.8e-21 73.2 9.9 2.3e-06 27.1 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 OPL21037.1 - 1.5e-09 36.9 11.8 0.0011 18.3 0.8 4.8 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.6 OPL21037.1 - 1.8e-09 37.8 0.1 0.00013 22.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 OPL21037.1 - 9.5e-05 22.3 4.6 0.018 15.0 0.6 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 OPL21037.1 - 0.00031 20.7 1.4 0.25 11.3 0.1 2.3 2 0 0 2 2 2 2 Tellurite resistance protein TerB SPARC_Ca_bdg PF10591.9 OPL21037.1 - 0.00047 20.5 1.9 0.74 10.2 0.1 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF2666 PF10869.8 OPL21037.1 - 0.0028 17.9 0.4 0.0084 16.3 0.2 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF2666) Dockerin_1 PF00404.18 OPL21037.1 - 0.0053 16.9 1.2 1.1 9.5 0.0 2.6 2 1 0 2 2 2 1 Dockerin type I domain DUF3349 PF11829.8 OPL21037.1 - 0.0094 16.7 0.2 0.65 10.8 0.0 2.4 1 1 2 3 3 3 2 Protein of unknown function (DUF3349) Spore_III_AB PF09548.10 OPL21037.1 - 0.11 12.6 0.8 0.27 11.3 0.3 1.8 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF3970 PF13113.6 OPL21037.1 - 0.14 12.4 0.6 6.9 7.0 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) PAH PF02671.21 OPL21037.1 - 1.9 8.7 5.2 0.33 11.1 0.9 2.3 3 1 0 3 3 2 0 Paired amphipathic helix repeat VKOR PF07884.14 OPL21038.1 - 3.8e-09 36.8 0.1 4e-09 36.7 0.1 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family DUF4559 PF15112.6 OPL21040.1 - 0.009 15.7 0.0 0.26 10.9 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4559) Nucleotid_trans PF03407.16 OPL21041.1 - 6.1e-18 65.6 0.0 1.1e-17 64.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase UPRTase PF14681.6 OPL21041.1 - 0.087 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase SAP130_C PF16014.5 OPL21042.1 - 1.2e-32 113.6 33.1 5.8e-31 108.0 11.0 3.9 1 1 2 3 3 3 2 Histone deacetylase complex subunit SAP130 C-terminus Nucleo_P87 PF07267.11 OPL21042.1 - 0.033 13.0 7.2 0.045 12.6 7.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 tRNA-synt_2 PF00152.20 OPL21043.1 - 1.9e-41 142.2 0.2 2.5e-41 141.8 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 OPL21043.1 - 9.8e-08 31.9 0.0 1.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4469 PF14734.6 OPL21043.1 - 0.077 13.2 0.2 12 6.2 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4469) with IG-like fold tRNA-synt_2d PF01409.20 OPL21043.1 - 0.084 12.3 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) SPATA9 PF15824.5 OPL21043.1 - 0.15 11.3 0.1 0.23 10.7 0.1 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 9 PhyH PF05721.13 OPL21045.1 - 4.1e-05 23.9 0.0 5.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Rad9 PF04139.13 OPL21045.1 - 0.075 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Rad9 Sulfotransfer_3 PF13469.6 OPL21046.1 - 0.014 15.7 0.0 0.019 15.3 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family UPF0640 PF15114.6 OPL21046.1 - 0.63 9.9 2.4 28 4.6 0.4 2.6 2 1 1 3 3 3 0 Uncharacterised protein family UPF0640 Trm112p PF03966.16 OPL21047.1 - 1.3e-06 28.9 0.0 2.4e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Trm112p-like protein CARD PF00619.21 OPL21048.1 - 6.7e-14 51.7 0.0 9.4e-14 51.2 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 OPL21048.1 - 1.9e-06 27.8 0.0 2.5e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain MID_MedPIWI PF18296.1 OPL21048.1 - 0.036 13.9 0.1 0.041 13.7 0.1 1.2 1 0 0 1 1 1 0 MID domain of medPIWI Roc PF08477.13 OPL21049.1 - 1.1e-10 41.7 1.1 1.8e-10 41.1 0.5 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Rhodanese PF00581.20 OPL21050.1 - 1.8e-24 86.3 0.0 2.6e-13 50.4 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Neur_chan_LBD PF02931.23 OPL21052.1 - 6.8e-54 182.6 0.1 9.5e-54 182.1 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 OPL21052.1 - 5.1e-24 85.6 4.9 6.9e-24 85.2 4.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region zf-BED PF02892.15 OPL21054.1 - 0.12 12.5 0.4 0.31 11.1 0.4 1.6 1 1 0 1 1 1 0 BED zinc finger GBP PF02263.19 OPL21055.1 - 4.7e-16 58.8 0.4 8e-16 58.1 0.0 1.5 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 OPL21055.1 - 1.6e-06 27.8 0.2 2.1e-06 27.4 0.2 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Tiam_CC_Ex PF18385.1 OPL21055.1 - 0.00019 21.8 0.6 0.0028 18.0 0.0 2.6 2 1 0 2 2 2 1 T-lymphoma invasion and metastasis CC-Ex domain DUF2207 PF09972.9 OPL21055.1 - 0.002 17.0 0.1 0.0023 16.8 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3767 PF12597.8 OPL21055.1 - 0.079 12.8 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) TIM PF00121.18 OPL21056.1 - 5.3e-69 232.3 1.0 6.2e-69 232.1 1.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase adh_short PF00106.25 OPL21057.1 - 7.5e-13 48.4 0.0 2.7e-12 46.6 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL21057.1 - 1.5e-09 37.8 0.0 6.5e-08 32.4 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase GA-like PF17573.2 OPL21057.1 - 0.11 12.4 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 GA-like domain Glutaredoxin PF00462.24 OPL21057.1 - 0.17 12.1 0.0 0.46 10.7 0.0 1.7 2 0 0 2 2 2 0 Glutaredoxin Anoct_dimer PF16178.5 OPL21058.1 - 1e-08 35.2 0.5 1.6e-08 34.6 0.5 1.5 1 1 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin HEPN_DZIP3 PF18738.1 OPL21059.1 - 7.4e-07 29.0 0.1 7.4e-07 29.0 0.1 3.3 4 0 0 4 4 4 1 DZIP3/ hRUL138-like HEPN DUF483 PF04467.12 OPL21059.1 - 0.31 11.1 4.1 1.5 8.8 0.1 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF483) GARP PF16731.5 OPL21059.1 - 1.3 8.7 5.0 0.53 10.0 1.4 2.1 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Band_3_cyto PF07565.13 OPL21060.1 - 5.4e-39 134.6 1.3 6.6e-39 134.3 1.3 1.0 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Macoilin PF09726.9 OPL21060.1 - 0.0094 14.6 0.1 0.0096 14.5 0.1 1.1 1 0 0 1 1 1 1 Macoilin family RNA_pol_Rpc4 PF05132.14 OPL21060.1 - 0.058 13.8 0.2 0.086 13.3 0.2 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 TCO89 PF10452.9 OPL21061.1 - 0.13 11.2 1.5 0.19 10.7 1.5 1.1 1 0 0 1 1 1 0 TORC1 subunit TCO89 SpvB PF03534.13 OPL21062.1 - 0.0078 15.4 0.4 0.0085 15.3 0.4 1.1 1 0 0 1 1 1 1 Salmonella virulence plasmid 65kDa B protein FadA PF09403.10 OPL21063.1 - 0.01 16.3 1.3 0.017 15.6 1.3 1.4 1 0 0 1 1 1 0 Adhesion protein FadA DUF641 PF04859.12 OPL21063.1 - 0.026 14.9 2.6 0.041 14.2 2.6 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) PRKG1_interact PF15898.5 OPL21063.1 - 0.036 15.0 1.1 0.036 15.0 1.1 2.0 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain BRE1 PF08647.11 OPL21063.1 - 0.082 13.0 5.3 0.14 12.3 4.1 1.9 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase TssO PF17561.2 OPL21063.1 - 0.14 12.2 2.8 0.22 11.6 2.6 1.5 1 1 0 1 1 1 0 Type VI secretion system, TssO Rota_VP2 PF05087.12 OPL21063.1 - 0.16 10.1 2.7 0.17 10.0 2.7 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein TMPIT PF07851.13 OPL21063.1 - 0.22 10.7 4.0 0.28 10.4 4.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 OPL21063.1 - 0.35 10.9 2.9 0.47 10.5 2.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Ephrin_rec_like PF07699.13 OPL21065.1 - 0.026 14.3 1.0 0.026 14.3 1.0 5.5 1 1 2 4 4 4 0 Putative ephrin-receptor like Ephrin_rec_like PF07699.13 OPL21066.1 - 7.1e-06 25.7 93.0 0.019 14.7 7.2 11.4 4 4 6 10 10 10 7 Putative ephrin-receptor like TNFR_c6 PF00020.18 OPL21066.1 - 0.88 10.0 64.2 0.19 12.2 1.9 9.6 8 4 0 8 8 8 0 TNFR/NGFR cysteine-rich region Peptidase_C14 PF00656.22 OPL21068.1 - 1.8e-12 47.8 0.0 2e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 Caspase domain 7tm_2 PF00002.24 OPL21070.1 - 1.2e-34 119.7 8.6 1.4e-34 119.5 8.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) MIEAP PF16026.5 OPL21071.1 - 5.2e-23 82.3 0.7 5.2e-23 82.3 0.7 2.4 3 0 0 3 3 3 1 Mitochondria-eating protein VPS13_C PF16909.5 OPL21072.1 - 3e-20 72.7 6.1 2.6e-19 69.7 0.2 2.6 2 1 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 OPL21072.1 - 3.2e-07 30.6 0.0 5.9e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Ground-like PF04155.18 OPL21073.1 - 0.012 16.3 0.0 0.014 16.1 0.0 1.1 1 0 0 1 1 1 0 Ground-like domain PTPlike_phytase PF14566.6 OPL21074.1 - 1.2e-18 67.7 0.5 2.6e-18 66.6 0.1 1.7 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 OPL21074.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Peptidase_S49_N PF08496.10 OPL21075.1 - 0.096 12.8 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4834 PF16118.5 OPL21075.1 - 0.13 13.3 1.8 0.15 13.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Gly-zipper_YMGG PF13441.6 OPL21075.1 - 0.36 10.6 6.1 0.58 9.9 6.1 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 OPL21075.1 - 0.77 9.8 6.8 1.7 8.7 6.8 1.5 1 1 0 1 1 1 0 Glycine zipper CBM-like PF14683.6 OPL21076.1 - 0.059 13.2 0.0 0.081 12.8 0.0 1.4 1 1 0 1 1 1 0 Polysaccharide lyase family 4, domain III BPA_C PF18040.1 OPL21076.1 - 0.095 12.6 0.1 0.18 11.8 0.1 1.5 1 1 0 1 1 1 0 beta porphyranase A C-terminal DUF3113 PF11310.8 OPL21076.1 - 0.099 12.6 0.2 0.2 11.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) VWC PF00093.18 OPL21077.1 - 0.0008 19.7 34.5 0.085 13.2 13.9 2.2 2 0 0 2 2 2 2 von Willebrand factor type C domain PTS_2-RNA PF01885.16 OPL21078.1 - 8.6e-11 42.2 0.0 3.2e-10 40.4 0.0 1.8 2 0 0 2 2 2 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Neur_chan_LBD PF02931.23 OPL21079.1 - 2.4e-31 108.8 0.1 3.3e-31 108.4 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF3992 PF13157.6 OPL21079.1 - 0.1 13.3 0.0 25 5.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3992) GRIP PF01465.20 OPL21080.1 - 2.6e-15 56.0 0.2 2.6e-15 56.0 0.2 1.9 2 0 0 2 2 1 1 GRIP domain DUF3584 PF12128.8 OPL21080.1 - 0.00043 18.0 12.0 0.00046 17.9 12.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Tropomyosin_1 PF12718.7 OPL21080.1 - 0.00096 19.3 20.3 0.00096 19.3 20.3 2.1 1 1 1 2 2 2 1 Tropomyosin like TMF_TATA_bd PF12325.8 OPL21080.1 - 0.0011 19.2 15.0 0.0011 19.2 15.0 2.6 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding HAUS5 PF14817.6 OPL21080.1 - 0.0021 16.9 7.0 0.0024 16.7 7.0 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 TPR_MLP1_2 PF07926.12 OPL21080.1 - 0.0023 18.0 19.6 0.0023 18.0 19.6 2.1 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.12 OPL21080.1 - 0.0039 17.6 17.5 0.18 12.3 7.1 2.4 1 1 1 2 2 2 2 Nucleopolyhedrovirus P10 protein AAA_13 PF13166.6 OPL21080.1 - 0.015 14.0 18.9 0.024 13.3 18.9 1.3 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 OPL21080.1 - 0.027 13.4 27.4 0.016 14.1 15.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 OPL21080.1 - 0.027 13.8 26.9 0.27 10.5 26.8 2.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spectrin PF00435.21 OPL21080.1 - 0.043 14.3 20.0 0.49 10.9 16.3 2.5 1 1 1 2 2 2 0 Spectrin repeat Med30 PF11315.8 OPL21080.1 - 0.055 13.7 15.2 0.14 12.3 15.0 1.8 1 1 0 1 1 1 0 Mediator complex subunit 30 DUF745 PF05335.13 OPL21080.1 - 0.057 13.1 12.8 0.046 13.4 11.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF4407 PF14362.6 OPL21080.1 - 0.062 12.6 15.3 0.66 9.3 15.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 OPL21080.1 - 0.073 12.9 0.9 0.073 12.9 0.9 4.0 1 1 3 4 4 4 0 Septum formation initiator ATG16 PF08614.11 OPL21080.1 - 0.13 12.4 27.1 1.4 9.1 12.7 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) KLRAQ PF10205.9 OPL21080.1 - 0.16 12.2 26.0 0.71 10.1 1.6 3.6 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein MAD PF05557.13 OPL21080.1 - 0.2 10.0 27.8 0.33 9.3 27.8 1.3 1 0 0 1 1 1 0 Mitotic checkpoint protein Cnn_1N PF07989.11 OPL21080.1 - 0.3 11.3 23.4 0.87 9.8 14.2 3.6 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 FPP PF05911.11 OPL21080.1 - 0.31 9.2 24.3 0.59 8.3 24.3 1.4 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil SlyX PF04102.12 OPL21080.1 - 0.43 11.2 20.5 1.4 9.6 1.5 3.1 1 1 2 3 3 2 0 SlyX Herpes_UL6 PF01763.16 OPL21080.1 - 0.48 8.9 11.8 0.74 8.3 11.8 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like Gp58 PF07902.11 OPL21080.1 - 0.61 8.3 12.5 7.5 4.7 12.5 2.0 1 1 0 1 1 1 0 gp58-like protein DUF2779 PF11074.8 OPL21080.1 - 0.65 10.5 5.3 0.33 11.4 2.3 1.9 2 0 0 2 2 2 0 Domain of unknown function(DUF2779) UPF0242 PF06785.11 OPL21080.1 - 0.88 9.6 30.0 0.18 11.9 23.3 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 OPL21080.1 - 1 8.6 17.6 1.8 7.8 17.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF773 PF05600.12 OPL21080.1 - 1.2 7.7 23.9 0.92 8.2 22.4 1.5 2 0 0 2 2 2 0 CDK5 regulatory subunit-associated protein 3 HMMR_N PF15905.5 OPL21080.1 - 1.5 8.3 28.5 2.5 7.5 28.5 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal HrpB7 PF09486.10 OPL21080.1 - 1.6 9.1 9.4 8 6.8 0.1 2.6 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF148 PF02520.17 OPL21080.1 - 1.6 8.9 20.8 1.4 9.1 17.2 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF148 MscS_porin PF12795.7 OPL21080.1 - 2.1 7.8 27.0 0.071 12.6 17.7 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Lebercilin PF15619.6 OPL21080.1 - 2.1 7.9 29.8 0.11 12.2 19.2 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 OPL21080.1 - 2.2 8.4 21.7 0.64 10.2 12.2 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FliD_C PF07195.12 OPL21080.1 - 2.2 7.6 18.3 1.2e+02 2.0 18.3 2.3 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus ADIP PF11559.8 OPL21080.1 - 2.7 8.1 27.8 6.7 6.8 15.2 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4200 PF13863.6 OPL21080.1 - 2.9 8.3 25.6 0.27 11.6 7.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) FapA PF03961.13 OPL21080.1 - 3.2 6.3 15.3 4.8 5.7 15.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Phage_GPO PF05929.11 OPL21080.1 - 3.3 7.3 15.1 5.2 6.6 15.1 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DASH_Dam1 PF08653.10 OPL21080.1 - 3.3 7.6 10.3 10 6.0 1.3 3.4 2 1 1 3 3 3 0 DASH complex subunit Dam1 MPS2 PF17060.5 OPL21080.1 - 3.3 6.9 16.9 3.8 6.7 7.5 2.3 1 1 1 2 2 2 0 Monopolar spindle protein 2 Phage_GP20 PF06810.11 OPL21080.1 - 3.7 7.3 23.7 3 7.6 19.5 2.6 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF4795 PF16043.5 OPL21080.1 - 3.9 7.0 22.7 66 3.0 22.4 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Nup54 PF13874.6 OPL21080.1 - 4 7.5 17.0 1.5 8.9 13.6 1.9 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 VSG_B PF13206.6 OPL21080.1 - 4.6 6.4 12.0 6.2 6.0 12.0 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain APG6_N PF17675.1 OPL21080.1 - 5.5 7.5 30.5 0.12 12.9 19.2 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region CENP-Q PF13094.6 OPL21080.1 - 5.5 7.2 26.6 0.1 12.8 11.7 2.6 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF16 PF01519.16 OPL21080.1 - 6.4 7.3 24.9 13 6.4 10.0 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Exonuc_VII_L PF02601.15 OPL21080.1 - 6.4 6.2 19.0 7.6 6.0 18.1 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Snapin_Pallidin PF14712.6 OPL21080.1 - 7.4 7.1 22.6 1 9.8 14.3 3.1 1 1 1 2 2 2 0 Snapin/Pallidin FliJ PF02050.16 OPL21080.1 - 9.4 6.5 22.1 5 7.4 7.9 2.3 1 1 1 2 2 2 0 Flagellar FliJ protein DUF2730 PF10805.8 OPL21080.1 - 9.5 6.4 10.2 2.9 8.0 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF1664 PF07889.12 OPL21080.1 - 9.7 6.3 15.5 5.2 7.1 5.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) MBT PF02820.18 OPL21081.1 - 2.6e-50 168.7 0.2 1.9e-24 85.8 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SAM_1 PF00536.30 OPL21081.1 - 7.9e-10 39.0 0.2 1.5e-09 38.1 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 OPL21081.1 - 0.00033 20.7 0.0 0.00058 19.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 OPL21081.1 - 0.00077 19.4 0.1 0.0018 18.2 0.1 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 OPL21081.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Ste50p, sterile alpha motif CAP_N PF01213.19 OPL21083.1 - 1.2 8.5 7.1 1.6 8.1 7.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal EGF PF00008.27 OPL21084.1 - 3.5e-22 78.4 47.2 4.3e-07 30.1 5.5 4.2 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 OPL21084.1 - 1.4e-12 47.8 46.4 0.00013 22.4 8.2 5.2 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_CA PF07645.15 OPL21084.1 - 1.6e-11 44.2 55.3 1e-07 32.0 8.2 4.2 3 1 1 4 4 4 4 Calcium-binding EGF domain EGF_2 PF07974.13 OPL21084.1 - 2.4e-11 43.8 57.4 0.0011 19.3 11.9 4.3 4 0 0 4 4 4 4 EGF-like domain EGF_3 PF12947.7 OPL21084.1 - 4.3e-05 23.6 41.6 0.17 12.1 4.2 4.9 2 1 2 4 4 4 3 EGF domain cEGF PF12662.7 OPL21084.1 - 0.0088 16.0 4.1 0.0088 16.0 4.1 6.3 5 2 0 5 5 5 4 Complement Clr-like EGF-like FXa_inhibition PF14670.6 OPL21084.1 - 1.2 9.5 43.0 3.4 8.0 1.1 4.6 1 1 3 4 4 4 0 Coagulation Factor Xa inhibitory site Urocanase PF01175.18 OPL21086.1 - 1.3e-05 25.0 0.0 0.00027 20.6 0.0 1.9 1 1 1 2 2 2 2 Urocanase Rossmann-like domain Urocanase_C PF17392.2 OPL21087.1 - 7.4e-28 97.3 0.0 9.1e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 Urocanase C-terminal domain Urocanase PF01175.18 OPL21087.1 - 9.3e-10 38.5 0.3 4.1e-09 36.4 0.0 1.8 2 0 0 2 2 2 1 Urocanase Rossmann-like domain DUF1320 PF07030.12 OPL21087.1 - 0.11 12.7 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) GRAM PF02893.20 OPL21088.1 - 0.0002 21.2 0.0 0.00022 21.1 0.0 1.1 1 0 0 1 1 1 1 GRAM domain EGF_2 PF07974.13 OPL21089.1 - 4.5 7.7 10.8 0.6 10.5 0.9 3.3 3 0 0 3 3 3 0 EGF-like domain OHCU_decarbox PF09349.10 OPL21090.1 - 1e-41 143.0 0.0 1.3e-41 142.7 0.0 1.1 1 0 0 1 1 1 1 OHCU decarboxylase PPV_E2_C PF00511.17 OPL21090.1 - 0.013 15.6 0.2 0.025 14.7 0.2 1.4 1 0 0 1 1 1 0 E2 (early) protein, C terminal DUF1885 PF08968.10 OPL21090.1 - 0.082 13.0 0.0 0.16 12.1 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1885) CG-1 PF03859.16 OPL21091.1 - 2e-39 133.9 0.3 3.3e-39 133.3 0.3 1.3 1 0 0 1 1 1 1 CG-1 domain TTL PF03133.15 OPL21094.1 - 3.1e-29 102.0 3.8 5.3e-28 98.0 3.8 2.1 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family Orthopox_F7 PF05813.12 OPL21094.1 - 0.062 13.4 0.0 0.099 12.8 0.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus F7 protein FERM_M PF00373.18 OPL21095.1 - 2.4e-12 47.3 0.0 4.1e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 OPL21095.1 - 0.005 17.2 0.2 0.011 16.1 0.2 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain Arv1 PF04161.13 OPL21099.1 - 5.1e-11 43.1 1.2 7.1e-11 42.7 1.2 1.2 1 0 0 1 1 1 1 Arv1-like family C1q PF00386.21 OPL21100.1 - 3.3e-05 24.1 0.1 4.6e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 C1q domain SyrA PF11089.8 OPL21100.1 - 0.1 12.7 0.4 0.2 11.7 0.4 1.5 1 0 0 1 1 1 0 Exopolysaccharide production repressor CCDC85 PF10226.9 OPL21101.1 - 9.6e-47 159.2 11.7 9.6e-47 159.2 11.7 2.3 1 1 1 2 2 2 1 CCDC85 family TSC22 PF01166.18 OPL21101.1 - 0.00043 20.5 14.2 0.14 12.5 1.9 3.2 3 0 0 3 3 3 2 TSC-22/dip/bun family STAT_alpha PF01017.20 OPL21101.1 - 0.0038 17.1 2.6 0.0038 17.1 2.6 1.7 2 0 0 2 2 2 1 STAT protein, all-alpha domain Noelin-1 PF12308.8 OPL21101.1 - 0.013 15.4 0.3 0.013 15.4 0.3 2.2 2 1 0 2 2 2 0 Neurogenesis glycoprotein AAA_lid_9 PF17871.1 OPL21101.1 - 0.022 14.7 2.6 0.3 11.0 0.5 2.4 2 0 0 2 2 2 0 AAA lid domain YabA PF06156.13 OPL21101.1 - 0.034 14.8 9.3 2.2 8.9 1.5 3.1 2 1 1 3 3 3 0 Initiation control protein YabA FlxA PF14282.6 OPL21101.1 - 0.045 13.7 2.2 0.045 13.7 2.2 2.6 3 0 0 3 3 2 0 FlxA-like protein UPF0242 PF06785.11 OPL21101.1 - 0.1 12.7 11.4 0.39 10.8 0.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF5320 PF17253.2 OPL21101.1 - 0.12 13.5 0.6 3.2 8.9 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5320) ZapB PF06005.12 OPL21101.1 - 0.14 12.6 18.2 6.8 7.2 0.1 3.2 3 0 0 3 3 3 0 Cell division protein ZapB DUF4618 PF15397.6 OPL21101.1 - 0.16 11.4 12.8 0.76 9.1 3.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Jnk-SapK_ap_N PF09744.9 OPL21101.1 - 0.38 11.0 15.1 1.2 9.3 2.7 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.5 OPL21101.1 - 0.4 11.0 10.7 2.7 8.3 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) Arm-DNA-bind_5 PF17293.2 OPL21101.1 - 0.53 10.8 12.3 15 6.1 1.0 3.7 2 1 2 4 4 4 0 Arm DNA-binding domain Swi5 PF07061.11 OPL21101.1 - 0.79 9.9 7.0 1.1 9.3 0.5 2.8 3 0 0 3 3 3 0 Swi5 CENP-F_leu_zip PF10473.9 OPL21101.1 - 1.5 8.9 15.5 1.5 8.8 2.6 2.6 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 OPL21101.1 - 1.6 8.5 20.8 1.3 8.9 0.5 3.1 2 1 1 3 3 3 0 Septum formation initiator TMF_TATA_bd PF12325.8 OPL21101.1 - 1.6 8.9 14.4 0.21 11.8 1.9 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding GAS PF13851.6 OPL21101.1 - 1.9 7.8 16.3 0.73 9.1 2.2 2.9 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.21 OPL21101.1 - 2.6 8.2 20.0 0.51 10.5 2.5 3.5 3 1 0 3 3 3 0 bZIP transcription factor DUF4407 PF14362.6 OPL21101.1 - 3.3 7.0 5.1 5 6.4 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Rabaptin PF03528.15 OPL21101.1 - 3.5 6.2 15.3 0.5 9.0 0.6 2.8 2 1 1 3 3 3 0 Rabaptin Ax_dynein_light PF10211.9 OPL21101.1 - 3.6 7.5 13.8 1.4 8.8 1.8 2.8 2 1 1 3 3 3 0 Axonemal dynein light chain DUF2802 PF10975.8 OPL21101.1 - 4.2 7.6 10.6 5.2 7.3 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) DUF4140 PF13600.6 OPL21101.1 - 4.3 7.8 7.2 0.71 10.3 0.5 2.5 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) TMF_DNA_bd PF12329.8 OPL21101.1 - 4.8 7.3 14.6 6.7 6.8 3.9 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF3573 PF12097.8 OPL21101.1 - 9 5.0 7.6 5.7 5.7 1.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) FapA PF03961.13 OPL21101.1 - 9.2 4.7 7.0 1.1 7.7 0.8 1.9 1 1 0 2 2 2 0 Flagellar Assembly Protein A Spc24 PF08286.11 OPL21101.1 - 10 6.5 11.9 5.5 7.3 0.5 2.9 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 TIR_2 PF13676.6 OPL21102.1 - 8.2e-12 45.8 0.0 1e-11 45.5 0.0 1.1 1 0 0 1 1 1 1 TIR domain C1q PF00386.21 OPL21103.1 - 1.2e-12 48.2 0.2 1.5e-12 47.8 0.2 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL21103.1 - 0.00028 20.8 1.5 0.00044 20.2 0.1 1.8 2 0 0 2 2 2 1 BclA C-terminal domain Man-6-P_recep PF02157.15 OPL21104.1 - 4.2e-12 45.7 0.0 4.9e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor Cuticle_2 PF08184.11 OPL21104.1 - 0.09 12.8 0.0 0.73 9.9 0.0 2.1 2 0 0 2 2 2 0 Cuticle protein 7 isoform family zf-RING_2 PF13639.6 OPL21105.1 - 2.8e-08 33.9 3.0 6.4e-08 32.8 3.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 OPL21105.1 - 7e-08 32.2 3.3 1.6e-07 31.0 3.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 OPL21105.1 - 7.6e-08 32.5 3.4 1.2e-07 31.9 2.4 1.8 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 OPL21105.1 - 2.2e-07 30.7 3.3 2.2e-07 30.7 3.3 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 OPL21105.1 - 7e-06 25.7 2.8 7e-06 25.7 2.8 2.4 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.6 OPL21105.1 - 6.4e-05 22.8 2.7 6.4e-05 22.8 2.7 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 OPL21105.1 - 0.00024 21.0 3.9 0.00052 20.0 3.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 OPL21105.1 - 0.00042 20.1 2.5 0.00042 20.1 2.5 1.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 OPL21105.1 - 0.00094 19.2 2.6 0.0017 18.4 2.6 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 OPL21105.1 - 0.0042 16.7 0.8 0.0093 15.6 0.8 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 OPL21105.1 - 0.13 12.1 2.7 0.25 11.2 2.7 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF3510 PF12022.8 OPL21106.1 - 0.00035 21.0 0.3 0.0015 18.9 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3510) Cadherin PF00028.17 OPL21107.1 - 6.7e-07 29.7 0.7 0.021 15.3 0.0 2.1 1 1 1 2 2 2 2 Cadherin domain WSC PF01822.19 OPL21108.1 - 2.7e-10 40.3 5.6 3.9e-10 39.8 5.6 1.3 1 0 0 1 1 1 1 WSC domain Rhodanese PF00581.20 OPL21109.1 - 0.00012 22.6 0.0 0.00018 22.0 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain RabGAP-TBC PF00566.18 OPL21109.1 - 0.00035 20.3 0.0 0.00046 19.9 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Anoct_dimer PF16178.5 OPL21110.1 - 1.9e-41 142.2 0.2 2.1e-41 142.1 0.2 1.0 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Anoctamin PF04547.12 OPL21110.1 - 0.0001 21.3 1.0 0.00014 20.9 1.0 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel TxDE PF18711.1 OPL21110.1 - 0.14 12.3 0.0 0.84 9.8 0.0 2.1 2 1 0 2 2 2 0 Toxoflavin-degrading enzyme Anoctamin PF04547.12 OPL21111.1 - 3.9e-16 59.0 0.2 4e-16 58.9 0.2 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel BACK PF07707.15 OPL21112.1 - 4e-14 52.6 3.7 2.3e-12 46.9 2.5 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 OPL21112.1 - 3e-12 46.7 0.2 7e-12 45.6 0.2 1.7 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 OPL21112.1 - 6.4e-05 23.1 4.7 0.67 10.3 0.1 5.7 6 0 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 OPL21112.1 - 0.0011 19.0 0.1 8.8 6.4 0.0 3.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 OPL21112.1 - 0.048 13.3 1.7 4.4 7.0 0.0 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 OPL21112.1 - 0.13 12.6 0.2 19 5.7 0.0 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 OPL21112.1 - 0.15 12.1 0.0 1.8 8.7 0.0 2.5 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 OPL21112.1 - 1.3 9.1 6.1 9.3 6.4 0.3 3.9 4 0 0 4 4 4 0 Kelch motif Phosducin PF02114.16 OPL21113.1 - 0.00034 19.6 3.9 0.00038 19.5 3.6 1.3 1 1 0 1 1 1 1 Phosducin SAM_PNT PF02198.16 OPL21114.1 - 2.9e-11 43.2 0.2 2.5e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 OPL21114.1 - 0.13 12.1 0.7 3 7.7 0.0 2.6 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) GATase_6 PF13522.6 OPL21116.1 - 2e-17 63.7 0.0 6e-17 62.1 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 OPL21116.1 - 2.5e-14 53.2 0.0 9e-14 51.4 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_4 PF13230.6 OPL21116.1 - 1.4e-06 27.5 0.0 2e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PEMT PF04191.13 OPL21117.1 - 3.5e-21 75.6 5.5 4.1e-21 75.4 5.5 1.1 1 0 0 1 1 1 1 Phospholipid methyltransferase US10 PF17617.2 OPL21117.1 - 0.26 11.3 1.7 0.31 11.1 1.7 1.2 1 0 0 1 1 1 0 Viral unique short region 10 Glyco_hydro_125 PF06824.11 OPL21119.1 - 0.0056 15.6 0.0 0.0064 15.4 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) SPOR PF05036.13 OPL21119.1 - 0.059 13.8 0.3 1.8 9.0 0.0 2.2 2 0 0 2 2 2 0 Sporulation related domain HSP70 PF00012.20 OPL21120.1 - 5.4e-07 28.2 0.0 6.4e-07 27.9 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL21120.1 - 0.083 11.7 0.4 0.14 10.9 0.4 1.6 1 1 0 1 1 1 0 MreB/Mbl protein Fra10Ac1 PF09725.9 OPL21121.1 - 1.7e-38 131.5 3.3 1.7e-38 131.5 3.3 1.5 2 0 0 2 2 2 1 Folate-sensitive fragile site protein Fra10Ac1 PriA_CRR PF18319.1 OPL21121.1 - 0.028 14.4 1.0 0.061 13.3 1.0 1.6 1 0 0 1 1 1 0 PriA DNA helicase Cys-rich region (CRR) domain Peptidase_S49_N PF08496.10 OPL21121.1 - 5.4 7.1 6.2 7.9 6.5 6.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal adh_short PF00106.25 OPL21122.1 - 8.6e-12 44.9 0.0 9.6e-12 44.8 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 OPL21122.1 - 5e-05 23.3 0.0 6.1e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 OPL21122.1 - 0.00076 19.5 0.0 0.00079 19.5 0.0 1.0 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 OPL21122.1 - 0.00087 19.2 0.0 0.001 19.0 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding adh_short_C2 PF13561.6 OPL21122.1 - 0.0018 17.9 0.0 0.0021 17.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase RmlD_sub_bind PF04321.17 OPL21122.1 - 0.011 14.8 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain 2-Hacid_dh_C PF02826.19 OPL21122.1 - 0.017 14.5 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 OPL21122.1 - 0.03 13.8 0.0 0.034 13.6 0.0 1.0 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 OPL21122.1 - 0.04 13.0 0.0 0.04 13.0 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 OPL21122.1 - 0.047 13.9 0.0 0.054 13.8 0.0 1.0 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain THAP PF05485.12 OPL21123.1 - 2.4e-05 25.2 0.2 3.2e-05 24.7 0.2 1.4 1 1 0 1 1 1 1 THAP domain Calreticulin PF00262.18 OPL21125.1 - 0.35 9.7 5.2 0.46 9.3 5.2 1.1 1 0 0 1 1 1 0 Calreticulin family EF-hand_7 PF13499.6 OPL21127.1 - 6e-10 39.4 0.7 1.4e-07 31.9 0.2 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_11 PF08976.11 OPL21127.1 - 2.2e-06 28.5 0.3 0.028 15.3 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 OPL21127.1 - 5.6e-06 25.9 0.3 1.7 8.8 0.0 4.2 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 OPL21127.1 - 6.5e-05 22.2 0.2 0.41 10.3 0.1 3.3 2 0 0 2 2 2 2 EF hand DUF3232 PF11554.8 OPL21127.1 - 0.015 15.7 0.2 0.04 14.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3232) EF-hand_8 PF13833.6 OPL21127.1 - 0.033 14.0 0.3 0.22 11.4 0.2 2.3 1 1 1 2 2 2 0 EF-hand domain pair PTS_IIA PF02255.16 OPL21127.1 - 0.077 13.0 1.9 0.12 12.5 0.6 2.0 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit Myb_DNA-bind_4 PF13837.6 OPL21127.1 - 0.082 13.3 3.4 2.2 8.7 1.4 2.9 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain SPARC_Ca_bdg PF10591.9 OPL21127.1 - 0.3 11.4 5.6 4.1 7.8 0.1 2.8 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 OPL21127.1 - 0.33 10.5 2.7 13 5.5 0.0 3.7 3 0 0 3 3 3 0 EF hand DUF4972 PF16342.5 OPL21128.1 - 0.025 14.3 0.2 0.029 14.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) cwf21 PF08312.12 OPL21128.1 - 2.2 8.5 10.0 17 5.7 1.6 2.1 1 1 1 2 2 2 0 cwf21 domain Aminotran_5 PF00266.19 OPL21129.1 - 6.7e-08 31.9 0.0 7.2e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V RDD PF06271.12 OPL21130.1 - 0.045 14.0 0.0 0.047 13.9 0.0 1.1 1 0 0 1 1 1 0 RDD family Lipocalin_7 PF14651.6 OPL21131.1 - 2.4e-07 30.7 0.7 4.8e-07 29.8 0.7 1.5 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF4562 PF15123.6 OPL21132.1 - 0.048 13.6 0.1 0.97 9.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4562) VWD PF00094.25 OPL21132.1 - 0.13 12.5 0.7 0.53 10.5 0.1 2.2 2 1 0 2 2 2 0 von Willebrand factor type D domain CDC45 PF02724.14 OPL21134.1 - 4.1e-37 127.8 0.1 5e-37 127.5 0.1 1.0 1 0 0 1 1 1 1 CDC45-like protein QIL1 PF15884.5 OPL21135.1 - 1.5e-13 51.1 2.1 2.3e-13 50.5 2.1 1.3 1 0 0 1 1 1 1 MICOS complex subunit MIC13, QIL1 Nup88 PF10168.9 OPL21137.1 - 0.28 8.9 14.6 0.37 8.6 14.6 1.1 1 0 0 1 1 1 0 Nuclear pore component DUF720 PF05302.11 OPL21137.1 - 3 7.7 20.1 5.9 6.8 5.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF720) HIP1_clath_bdg PF16515.5 OPL21137.1 - 7.5 7.2 17.5 11 6.7 2.6 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 C1q PF00386.21 OPL21138.1 - 2.7e-20 72.9 0.1 3.7e-20 72.4 0.1 1.2 1 0 0 1 1 1 1 C1q domain ABC_tran PF00005.27 OPL21140.1 - 2.3e-29 102.7 0.0 2.9e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 OPL21140.1 - 1e-06 28.3 0.2 0.00051 19.6 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 OPL21140.1 - 0.0036 17.4 0.1 0.0072 16.4 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 OPL21140.1 - 0.0044 16.8 0.0 0.009 15.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 OPL21140.1 - 0.0053 17.0 0.1 0.092 13.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.17 OPL21140.1 - 0.0054 16.9 0.7 0.011 15.9 0.3 1.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_30 PF13604.6 OPL21140.1 - 0.019 14.7 0.3 0.97 9.1 0.1 2.1 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 OPL21140.1 - 0.019 14.7 0.7 3.1 7.6 0.0 2.1 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_16 PF13191.6 OPL21140.1 - 0.02 15.2 0.1 0.028 14.8 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 OPL21140.1 - 0.041 13.6 0.2 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 OPL21140.1 - 0.046 13.4 0.0 0.051 13.2 0.0 1.1 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Mg_chelatase PF01078.21 OPL21140.1 - 0.058 12.8 0.2 0.11 11.9 0.1 1.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TrwB_AAD_bind PF10412.9 OPL21140.1 - 0.068 12.1 0.0 0.073 12.0 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Sigma54_activat PF00158.26 OPL21140.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_21 PF13304.6 OPL21140.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 OPL21140.1 - 0.17 12.3 0.2 0.35 11.3 0.2 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 OPL21140.1 - 0.26 10.5 1.2 0.35 10.0 0.2 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain Myticin-prepro PF10690.9 OPL21141.1 - 1.4e-05 25.2 1.3 1.6e-05 25.1 1.3 1.1 1 0 0 1 1 1 1 Myticin pre-proprotein from the mussel BcrAD_BadFG PF01869.20 OPL21142.1 - 0.051 13.1 0.0 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DUF325 PF03804.13 OPL21145.1 - 0.038 14.0 0.0 0.27 11.3 0.0 2.0 1 1 0 1 1 1 0 Viral proteins of unknown function EF-hand_7 PF13499.6 OPL21146.1 - 5.9e-12 45.9 0.8 8e-12 45.4 0.7 1.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 OPL21146.1 - 9.6e-12 43.6 1.0 3.9e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 OPL21146.1 - 1.4e-10 40.3 0.6 7.8e-07 28.5 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 OPL21146.1 - 2.6e-10 40.0 3.5 1.5e-08 34.3 0.4 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 OPL21146.1 - 0.003 17.0 1.8 1.4 8.5 0.1 2.4 2 0 0 2 2 2 2 EF hand Dockerin_1 PF00404.18 OPL21146.1 - 0.022 14.9 0.8 0.038 14.2 0.8 1.3 1 0 0 1 1 1 0 Dockerin type I domain EF-hand_14 PF17959.1 OPL21146.1 - 0.027 14.8 0.0 0.035 14.5 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain HTH_Tnp_Tc3_2 PF01498.18 OPL21146.1 - 0.04 14.1 0.0 0.07 13.4 0.0 1.3 1 0 0 1 1 1 0 Transposase DSPc PF00782.20 OPL21147.1 - 0.0012 18.7 1.7 0.0022 17.8 0.0 2.2 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Thg1C PF14413.6 OPL21147.1 - 0.3 11.2 4.6 0.57 10.3 4.6 1.5 1 1 0 1 1 1 0 Thg1 C terminal domain Glyco_hydro_31 PF01055.26 OPL21149.1 - 1.1e-35 123.7 2.2 1e-28 100.7 0.2 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 C1q PF00386.21 OPL21150.1 - 2.4e-20 73.0 0.1 5.1e-20 72.0 0.1 1.5 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL21150.1 - 1.3e-05 25.1 0.5 2.4e-05 24.2 0.5 1.4 1 0 0 1 1 1 1 BclA C-terminal domain HMG_box PF00505.19 OPL21151.1 - 1.2e-09 38.5 0.0 0.0024 18.3 0.0 2.6 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 OPL21151.1 - 0.00063 20.3 0.0 0.035 14.7 0.0 2.6 1 1 1 2 2 2 1 HMG-box domain CHDNT PF08073.12 OPL21151.1 - 0.095 12.7 0.0 0.31 11.0 0.0 1.9 2 0 0 2 2 2 0 CHDNT (NUC034) domain Fibrinogen_C PF00147.18 OPL21152.1 - 2e-43 148.8 1.5 2.3e-43 148.6 1.5 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 OPL21152.1 - 1.3e-05 24.6 0.1 1.4e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain GON PF08685.11 OPL21152.1 - 0.055 13.3 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 GON domain I-set PF07679.16 OPL21152.1 - 0.057 13.5 0.0 0.072 13.2 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain DNA_pol_B PF00136.21 OPL21153.1 - 0.025 13.3 0.0 0.036 12.8 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase family B Vac14_Fab1_bd PF12755.7 OPL21153.1 - 0.04 14.5 0.1 0.37 11.4 0.0 2.4 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region DUF5516 PF17637.2 OPL21154.1 - 0.11 12.3 0.2 0.16 11.7 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5516) AIG2_2 PF13772.6 OPL21156.1 - 6e-19 68.2 0.0 8.7e-19 67.7 0.0 1.2 1 0 0 1 1 1 1 AIG2-like family GGACT PF06094.12 OPL21156.1 - 2.7e-05 24.7 0.0 6.8e-05 23.5 0.0 1.6 2 0 0 2 2 2 1 Gamma-glutamyl cyclotransferase, AIG2-like DNA_ligase_A_C PF04679.15 OPL21157.1 - 1.1e-18 67.6 0.0 2.7e-18 66.4 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_A_M PF01068.21 OPL21157.1 - 1.1e-07 31.7 0.0 1.6e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DTHCT PF08070.11 OPL21157.1 - 0.39 11.5 27.4 0.19 12.5 9.9 2.8 1 1 2 3 3 3 0 DTHCT (NUC029) region tRNA-synt_2 PF00152.20 OPL21161.1 - 1.7e-41 142.3 0.2 2.2e-41 141.9 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 OPL21161.1 - 1.9e-07 31.0 0.0 3.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 OPL21161.1 - 0.082 12.4 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Pex24p PF06398.11 OPL21162.1 - 1.5e-08 34.1 20.6 0.00012 21.2 2.3 3.1 2 1 1 3 3 3 3 Integral peroxisomal membrane peroxin DCP1 PF06058.13 OPL21162.1 - 0.033 14.1 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 Dcp1-like decapping family Lyase_aromatic PF00221.19 OPL21163.1 - 2.1e-30 105.8 0.6 4.5e-18 65.2 0.1 3.0 1 1 2 3 3 3 3 Aromatic amino acid lyase Phage_integrase PF00589.22 OPL21164.1 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family Herpes_BBRF1 PF04793.12 OPL21164.1 - 0.029 13.4 0.1 0.037 13.1 0.1 1.2 1 0 0 1 1 1 0 BRRF1-like protein Methyltransf_FA PF12248.8 OPL21164.1 - 0.045 14.1 2.5 0.096 13.0 0.1 2.5 3 0 0 3 3 3 0 Farnesoic acid 0-methyl transferase Macoilin PF09726.9 OPL21165.1 - 0.44 9.1 18.7 0.59 8.6 18.7 1.3 1 0 0 1 1 1 0 Macoilin family Neur_chan_memb PF02932.16 OPL21165.1 - 2 8.4 16.6 2.9 7.9 16.2 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1392 PF07154.11 OPL21166.1 - 0.069 13.3 0.2 0.069 13.3 0.2 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1392) PCC_BT PF18140.1 OPL21166.1 - 0.18 12.1 0.4 0.88 9.9 0.4 2.1 1 1 0 1 1 1 0 Propionyl-coenzyme A carboxylase BT domain DUF4834 PF16118.5 OPL21167.1 - 0.0059 17.5 0.1 0.0084 17.1 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Ctr PF04145.15 OPL21167.1 - 0.066 13.8 0.0 0.1 13.2 0.0 1.3 1 0 0 1 1 1 0 Ctr copper transporter family DUF3139 PF11337.8 OPL21167.1 - 0.074 13.7 0.1 0.19 12.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) LRR19-TM PF15176.6 OPL21167.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.6 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF5356 PF17309.2 OPL21169.1 - 0.054 13.5 0.0 0.074 13.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5356) VWD PF00094.25 OPL21170.1 - 6e-14 52.6 0.1 1e-13 51.8 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain Profilin PF00235.19 OPL21172.1 - 0.072 13.4 0.1 3.2 8.1 0.0 2.9 3 1 0 3 3 3 0 Profilin CUB PF00431.20 OPL21174.1 - 4.7e-15 55.9 0.0 6.4e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 CUB domain HSP70 PF00012.20 OPL21175.1 - 5.9e-07 28.1 0.0 9.6e-07 27.4 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein BcrAD_BadFG PF01869.20 OPL21175.1 - 0.00083 18.9 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family RT_RNaseH_2 PF17919.1 OPL21176.1 - 2.9e-07 30.5 0.0 7.1e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 OPL21176.1 - 8.3e-05 22.8 0.1 0.00021 21.5 0.1 1.8 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_3 PF13456.6 OPL21176.1 - 0.019 14.8 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase-like MFS_1 PF07690.16 OPL21177.1 - 5.8e-12 45.2 4.6 6.2e-12 45.1 4.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 OPL21177.1 - 0.00027 20.4 2.2 0.00031 20.2 2.2 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB ATG22 PF11700.8 OPL21177.1 - 0.044 12.4 5.8 0.053 12.2 5.1 1.3 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like CN_hydrolase PF00795.22 OPL21178.1 - 1.1e-23 83.9 0.0 1.3e-23 83.7 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ATLF PF07737.11 OPL21178.1 - 0.015 14.6 0.0 0.018 14.3 0.0 1.1 1 0 0 1 1 1 0 Anthrax toxin lethal factor, N- and C-terminal domain Cu2_monoox_C PF03712.15 OPL21179.1 - 2.6e-22 79.0 0.8 3.4e-22 78.6 0.8 1.1 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain HSP70 PF00012.20 OPL21180.1 - 3.4e-222 738.9 5.5 4.4e-222 738.5 5.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL21180.1 - 4.3e-16 58.7 0.0 3.1e-14 52.5 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 OPL21180.1 - 0.0011 18.8 0.1 0.003 17.3 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Ppx-GppA PF02541.16 OPL21180.1 - 0.004 16.6 0.1 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 Ppx/GppA phosphatase family BcrAD_BadFG PF01869.20 OPL21180.1 - 0.032 13.7 0.1 3.6 7.0 0.0 2.3 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 OPL21180.1 - 0.053 14.0 6.2 6.5 7.2 0.3 3.7 3 2 0 3 3 3 0 Cell division protein FtsA Cys_rich_FGFR PF00839.17 OPL21180.1 - 0.14 12.3 0.2 0.42 10.8 0.2 1.8 1 0 0 1 1 1 0 Cysteine rich repeat GNAT_acetyltr_2 PF13718.6 OPL21180.1 - 0.54 9.6 5.2 2.1 7.7 0.0 2.5 3 0 0 3 3 3 0 GNAT acetyltransferase 2 Mago_nashi PF02792.14 OPL21180.1 - 1 9.5 5.0 8.7 6.5 2.0 2.3 2 0 0 2 2 2 0 Mago nashi protein Trp_dioxygenase PF03301.13 OPL21181.1 - 2.4e-38 132.4 5.6 2.4e-28 99.5 0.4 2.0 1 1 1 2 2 2 2 Tryptophan 2,3-dioxygenase DUF624 PF04854.14 OPL21181.1 - 0.1 12.8 0.1 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF624 Cadherin_3 PF16184.5 OPL21184.1 - 2.4e-160 523.4 44.7 4.9e-24 84.5 0.2 11.3 10 1 1 11 11 11 11 Cadherin-like Cadherin_4 PF17803.1 OPL21184.1 - 4.6e-09 36.8 11.3 0.018 15.6 0.7 6.5 6 0 0 6 6 6 4 Bacterial cadherin-like domain Big_9 PF17963.1 OPL21184.1 - 7.2e-07 29.9 27.0 0.22 12.3 3.4 8.3 8 2 0 8 8 8 4 Bacterial Ig domain CIDE-N PF02017.15 OPL21184.1 - 0.0041 17.1 0.1 3.4 7.7 0.0 2.7 2 0 0 2 2 2 2 CIDE-N domain CARD PF00619.21 OPL21185.1 - 0.012 15.6 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Caspase recruitment domain Arg_decarb_HB PF17810.1 OPL21186.1 - 0.047 13.9 0.1 0.2 11.9 0.0 2.0 1 1 0 1 1 1 0 Arginine decarboxylase helical bundle domain Erythro_esteras PF05139.14 OPL21186.1 - 0.17 11.6 0.8 0.25 11.1 0.8 1.1 1 0 0 1 1 1 0 Erythromycin esterase DEAD PF00270.29 OPL21187.1 - 8.1e-13 48.5 0.4 2.6e-12 46.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 OPL21187.1 - 1e-07 32.1 0.1 3.6e-07 30.4 0.0 1.8 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DUF2357 PF09823.9 OPL21187.1 - 0.013 14.7 0.1 0.02 14.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) LpoB PF13036.6 OPL21187.1 - 0.031 14.2 0.1 0.056 13.4 0.1 1.3 1 0 0 1 1 1 0 Peptidoglycan-synthase activator LpoB MPP6 PF10175.9 OPL21189.1 - 3.1e-25 89.2 6.6 3.1e-25 89.2 6.6 1.3 2 0 0 2 2 2 1 M-phase phosphoprotein 6 Phage_GPO PF05929.11 OPL21189.1 - 0.0046 16.6 0.7 0.0062 16.2 0.7 1.2 1 0 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase OAD_gamma PF04277.13 OPL21189.1 - 4.6 7.9 7.6 6 7.5 0.4 2.6 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain TM2 PF05154.16 OPL21190.1 - 1.4e-34 118.2 38.1 2e-12 47.2 7.5 3.1 3 0 0 3 3 3 3 TM2 domain Anoctamin PF04547.12 OPL21194.1 - 2e-18 66.5 0.1 2e-18 66.5 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF3168 PF11367.8 OPL21195.1 - 0.15 12.3 0.0 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3168) ATP-synt PF00231.19 OPL21196.1 - 6.4e-41 140.9 0.7 7.7e-41 140.6 0.7 1.0 1 0 0 1 1 1 1 ATP synthase Acyl-CoA_ox_N PF14749.6 OPL21197.1 - 2.8e-10 40.8 0.3 3.3e-10 40.6 0.3 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_ox_N PF14749.6 OPL21198.1 - 8.3e-08 32.8 0.0 1.4e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 OPL21198.1 - 0.072 13.3 0.0 0.091 13.0 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain ECR1_N PF14382.6 OPL21198.1 - 0.075 12.8 0.4 0.24 11.2 0.2 1.9 2 0 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region E1_DerP2_DerF2 PF02221.15 OPL21199.1 - 1.6e-20 73.9 0.3 2.5e-20 73.3 0.3 1.3 1 0 0 1 1 1 1 ML domain DUF1091 PF06477.13 OPL21199.1 - 0.0026 18.2 0.2 0.0051 17.3 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1091) Methyltransf_25 PF13649.6 OPL21200.1 - 3.1e-15 56.6 0.0 2e-14 54.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 OPL21200.1 - 5.7e-13 49.3 0.0 9.8e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 OPL21200.1 - 1.3e-09 38.1 0.0 2.4e-09 37.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 OPL21200.1 - 4e-08 32.9 0.0 1.4e-07 31.1 0.0 1.9 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 OPL21200.1 - 1.1e-06 29.3 0.0 1.8e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 OPL21200.1 - 8.9e-05 22.4 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 OPL21200.1 - 0.0041 16.9 0.4 0.009 15.8 0.1 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 OPL21200.1 - 0.0085 16.2 0.0 0.013 15.6 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase UPF0020 PF01170.18 OPL21200.1 - 0.033 13.9 0.0 0.049 13.3 0.0 1.4 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 MFS_1 PF07690.16 OPL21201.1 - 1.2e-20 73.8 0.0 1.3e-20 73.7 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 OPL21201.1 - 3.5e-05 22.9 0.1 3.7e-05 22.8 0.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 OPL21201.1 - 0.0011 17.3 0.3 0.0025 16.2 0.1 1.5 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family PUCC PF03209.15 OPL21201.1 - 0.018 14.1 2.2 0.023 13.7 2.2 1.1 1 0 0 1 1 1 0 PUCC protein MFS_1_like PF12832.7 OPL21201.1 - 0.041 12.7 3.2 0.038 12.8 1.8 1.5 1 1 1 2 2 2 0 MFS_1 like family MFS_4 PF06779.14 OPL21201.1 - 0.13 11.5 5.7 0.25 10.6 5.7 1.5 1 1 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB GTP_EFTU PF00009.27 OPL21202.1 - 2.1e-54 184.0 0.1 3.3e-54 183.4 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 OPL21202.1 - 2.8e-08 34.0 0.4 7.9e-08 32.6 0.4 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 OPL21202.1 - 1.4e-06 28.4 0.1 3.9e-06 26.9 0.1 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 OPL21202.1 - 1.6e-06 27.8 0.0 2.7e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 OPL21202.1 - 0.00083 18.8 0.1 0.0018 17.7 0.1 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 OPL21202.1 - 0.0093 15.4 0.0 0.015 14.8 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 OPL21202.1 - 0.015 15.3 0.0 0.045 13.8 0.0 1.9 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Septin PF00735.18 OPL21202.1 - 0.065 12.5 0.2 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 Septin Njmu-R1 PF15053.6 OPL21203.1 - 6.7e-16 58.3 0.8 7.5e-16 58.2 0.8 1.0 1 0 0 1 1 1 1 Mjmu-R1-like protein family NPL PF17800.1 OPL21203.1 - 0.051 14.2 0.1 0.069 13.7 0.1 1.3 1 0 0 1 1 1 0 Nucleoplasmin-like domain Thioredoxin_2 PF13098.6 OPL21203.1 - 0.097 13.1 1.1 6.9 7.2 0.0 2.3 1 1 1 2 2 2 0 Thioredoxin-like domain UPF0239 PF06783.11 OPL21204.1 - 0.048 13.8 0.9 0.17 12.1 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) DUF4342 PF14242.6 OPL21204.1 - 0.089 12.8 0.7 0.17 11.9 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) EphA2_TM PF14575.6 OPL21204.1 - 0.2 12.5 0.1 0.2 12.5 0.1 1.8 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TPP_enzyme_N PF02776.18 OPL21205.1 - 3.3e-16 59.4 0.0 4.1e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain F5_F8_type_C PF00754.25 OPL21208.1 - 8e-07 29.2 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Tachystatin_B PF11478.8 OPL21208.1 - 0.0051 16.7 0.5 0.017 15.0 0.5 1.9 1 0 0 1 1 1 1 Antimicrobial chitin binding protein tachystatin B DUF2606 PF10794.9 OPL21208.1 - 0.06 13.1 0.0 0.077 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) DUF1948 PF09185.10 OPL21208.1 - 0.071 13.0 0.1 0.095 12.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1948) Casc1_N PF15927.5 OPL21208.1 - 0.11 12.2 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus VWC PF00093.18 OPL21209.1 - 0.0036 17.6 13.3 0.0066 16.7 12.9 1.6 1 1 1 2 2 2 1 von Willebrand factor type C domain DUF3810 PF12725.7 OPL21210.1 - 0.019 14.3 0.6 0.021 14.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) 7tm_7 PF08395.12 OPL21210.1 - 0.032 13.4 0.2 0.039 13.2 0.2 1.1 1 0 0 1 1 1 0 7tm Chemosensory receptor HIP1_clath_bdg PF16515.5 OPL21210.1 - 0.046 14.3 2.1 0.12 13.0 2.0 1.7 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MFS_2 PF13347.6 OPL21210.1 - 0.072 11.6 0.2 0.23 10.0 0.2 1.7 1 1 0 1 1 1 0 MFS/sugar transport protein PgaD PF13994.6 OPL21210.1 - 0.095 12.8 0.1 0.12 12.4 0.1 1.2 1 0 0 1 1 1 0 PgaD-like protein DUF4408 PF14364.6 OPL21210.1 - 2 8.2 4.3 0.58 9.9 1.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4408) zf-MYND PF01753.18 OPL21211.1 - 2.9e-13 49.7 16.6 4.7e-13 49.0 16.6 1.3 1 0 0 1 1 1 1 MYND finger Ecl1 PF12855.7 OPL21211.1 - 0.0026 18.9 2.6 0.0034 18.6 2.6 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-C6H2 PF15801.5 OPL21211.1 - 0.015 15.6 11.5 0.028 14.7 11.5 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-HIT PF04438.16 OPL21211.1 - 0.29 11.0 13.4 0.15 11.9 10.6 2.0 3 0 0 3 3 3 0 HIT zinc finger Macro PF01661.21 OPL21212.1 - 2.9e-07 30.6 0.0 6e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Macro domain WWE PF02825.20 OPL21212.1 - 0.00091 19.8 0.1 0.0027 18.3 0.1 1.9 1 0 0 1 1 1 1 WWE domain Spc7 PF08317.11 OPL21213.1 - 1.3e-10 40.7 50.0 1.5e-05 24.1 25.9 2.1 1 1 1 2 2 2 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 OPL21213.1 - 3.9e-09 36.6 48.9 0.00014 21.9 27.4 4.1 1 1 2 3 3 3 2 TPR/MLP1/MLP2-like protein WEMBL PF05701.11 OPL21213.1 - 9.1e-08 31.2 47.5 2.2e-07 30.0 47.5 1.6 1 1 0 1 1 1 1 Weak chloroplast movement under blue light Golgin_A5 PF09787.9 OPL21213.1 - 1.3e-07 31.4 46.6 0.00051 19.6 31.3 2.2 1 1 1 2 2 2 2 Golgin subfamily A member 5 Filament PF00038.21 OPL21213.1 - 2.5e-07 30.6 41.7 0.00023 20.9 12.4 3.1 1 1 1 2 2 2 2 Intermediate filament protein Fez1 PF06818.15 OPL21213.1 - 1.9e-06 28.5 45.6 6.4e-05 23.5 32.4 2.4 1 1 1 2 2 2 1 Fez1 APG6_N PF17675.1 OPL21213.1 - 1.9e-06 28.4 46.0 0.0024 18.4 22.7 2.7 1 1 1 2 2 2 2 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 OPL21213.1 - 3.5e-06 27.1 57.3 0.00042 20.4 32.7 3.4 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MscS_porin PF12795.7 OPL21213.1 - 3.8e-06 26.6 34.8 0.00014 21.5 16.3 2.3 1 1 1 2 2 2 2 Mechanosensitive ion channel porin domain CALCOCO1 PF07888.11 OPL21213.1 - 7.2e-06 25.1 44.1 3.8e-05 22.7 35.0 2.0 1 1 1 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like HIP1_clath_bdg PF16515.5 OPL21213.1 - 3.3e-05 24.4 49.1 0.68 10.6 4.1 4.9 1 1 3 4 4 4 3 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF812 PF05667.11 OPL21213.1 - 7.1e-05 21.9 45.4 0.0001 21.4 45.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) KxDL PF10241.9 OPL21213.1 - 9.2e-05 22.6 37.1 0.18 12.1 5.3 5.0 1 1 4 5 5 5 3 Uncharacterized conserved protein GAS PF13851.6 OPL21213.1 - 0.00011 21.6 53.7 0.0068 15.8 26.5 3.1 1 1 2 3 3 3 2 Growth-arrest specific micro-tubule binding Atg14 PF10186.9 OPL21213.1 - 0.00013 21.2 41.5 0.034 13.3 28.6 3.0 1 1 2 3 3 3 2 Vacuolar sorting 38 and autophagy-related subunit 14 EzrA PF06160.12 OPL21213.1 - 0.00028 19.2 45.8 0.02 13.1 16.5 2.9 1 1 2 3 3 3 3 Septation ring formation regulator, EzrA Tropomyosin PF00261.20 OPL21213.1 - 0.00036 20.0 47.9 0.0048 16.3 14.8 3.4 1 1 2 3 3 3 2 Tropomyosin IFT57 PF10498.9 OPL21213.1 - 0.00055 19.0 48.5 0.083 11.8 18.0 2.9 1 1 2 3 3 3 3 Intra-flagellar transport protein 57 DUF3584 PF12128.8 OPL21213.1 - 0.00063 17.4 37.6 0.0007 17.3 20.6 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3584) DUF1664 PF07889.12 OPL21213.1 - 0.00098 19.2 43.1 0.15 12.1 8.2 3.6 1 1 3 4 4 4 1 Protein of unknown function (DUF1664) HMMR_N PF15905.5 OPL21213.1 - 0.0017 17.9 56.7 0.12 11.8 53.8 2.1 1 1 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal FliJ PF02050.16 OPL21213.1 - 0.0037 17.5 33.7 0.068 13.4 9.3 3.5 1 1 2 3 3 3 2 Flagellar FliJ protein Prefoldin_3 PF13758.6 OPL21213.1 - 0.0052 16.8 24.8 0.45 10.6 5.9 4.0 1 1 3 4 4 4 2 Prefoldin subunit ATG16 PF08614.11 OPL21213.1 - 0.01 16.1 48.1 0.19 11.9 19.7 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Uso1_p115_C PF04871.13 OPL21213.1 - 0.011 16.0 47.5 0.45 10.9 7.0 3.2 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2730 PF10805.8 OPL21213.1 - 0.025 14.7 38.1 0.32 11.1 9.0 4.6 1 1 4 5 5 5 0 Protein of unknown function (DUF2730) DUF745 PF05335.13 OPL21213.1 - 0.029 14.1 38.3 0.055 13.2 17.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) COG2 PF06148.11 OPL21213.1 - 0.031 14.4 40.0 2.7 8.1 7.7 4.9 1 1 4 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Phage_HK97_TLTM PF06120.11 OPL21213.1 - 0.031 13.5 33.5 0.038 13.2 15.6 2.6 1 1 1 2 2 2 0 Tail length tape measure protein CCDC144C PF14915.6 OPL21213.1 - 0.034 13.3 50.8 0.036 13.2 22.3 2.6 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region DUF3999 PF13163.6 OPL21213.1 - 0.037 13.2 9.5 0.27 10.4 9.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3999) HrpB7 PF09486.10 OPL21213.1 - 0.039 14.3 19.3 0.47 10.8 12.0 3.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Laminin_II PF06009.12 OPL21213.1 - 0.078 13.0 43.0 0.28 11.2 18.9 3.0 1 1 1 2 2 2 0 Laminin Domain II SecD-TM1 PF13721.6 OPL21213.1 - 0.082 13.4 24.9 0.6 10.6 4.1 3.6 1 1 3 4 4 4 0 SecD export protein N-terminal TM region Rhabdo_NV PF02484.15 OPL21213.1 - 0.085 13.0 1.9 18 5.5 0.2 2.8 1 1 1 2 2 2 0 Rhabdovirus Non-virion protein RasGAP_C PF03836.15 OPL21213.1 - 0.089 12.9 37.0 0.23 11.6 16.1 3.4 1 1 2 3 3 3 0 RasGAP C-terminus Seryl_tRNA_N PF02403.22 OPL21213.1 - 0.094 12.9 48.2 0.42 10.8 10.1 3.9 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain P_proprotein PF01483.20 OPL21213.1 - 0.1 12.6 5.0 39 4.3 0.3 4.1 1 1 4 5 5 5 0 Proprotein convertase P-domain Vps54_N PF10475.9 OPL21213.1 - 0.12 11.6 36.4 0.038 13.3 12.6 3.3 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex DUF4201 PF13870.6 OPL21213.1 - 0.12 12.0 49.7 0.58 9.9 28.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Rabaptin PF03528.15 OPL21213.1 - 0.13 10.9 38.2 0.0072 15.1 23.7 2.2 1 1 1 2 2 2 0 Rabaptin TolA_bind_tri PF16331.5 OPL21213.1 - 0.14 12.3 31.2 3.3 7.9 2.1 4.8 1 1 3 4 4 4 0 TolA binding protein trimerisation APG17 PF04108.12 OPL21213.1 - 0.14 11.2 35.4 0.89 8.6 12.6 2.4 1 1 1 2 2 2 0 Autophagy protein Apg17 OEP PF02321.18 OPL21213.1 - 0.15 11.9 28.4 0.66 9.8 8.5 3.1 1 1 2 3 3 3 0 Outer membrane efflux protein DUF724 PF05266.14 OPL21213.1 - 0.17 11.7 44.8 1.8 8.3 17.6 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Leu_zip PF15294.6 OPL21213.1 - 0.23 11.0 48.0 0.79 9.2 20.7 2.9 1 1 1 2 2 2 0 Leucine zipper WXG100 PF06013.12 OPL21213.1 - 0.3 11.4 15.0 14 6.0 1.3 5.4 1 1 3 4 4 4 0 Proteins of 100 residues with WXG zf-C4H2 PF10146.9 OPL21213.1 - 0.32 11.3 44.0 6.9 6.9 26.0 2.8 1 1 1 2 2 2 0 Zinc finger-containing protein Tup_N PF08581.10 OPL21213.1 - 0.35 11.2 39.6 0.35 11.2 7.0 4.0 1 1 2 3 3 3 0 Tup N-terminal GOLGA2L5 PF15070.6 OPL21213.1 - 0.36 9.4 38.5 1.3 7.6 35.2 2.1 1 1 1 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Prominin PF05478.11 OPL21213.1 - 0.51 8.2 32.6 1.2 7.0 32.6 1.6 1 1 0 1 1 1 0 Prominin FapA PF03961.13 OPL21213.1 - 0.52 8.9 46.0 1.5 7.3 12.8 3.0 1 1 2 3 3 3 0 Flagellar Assembly Protein A THOC7 PF05615.13 OPL21213.1 - 0.53 10.6 42.3 3.2 8.0 14.3 4.0 1 1 3 4 4 4 0 Tho complex subunit 7 TMPIT PF07851.13 OPL21213.1 - 0.61 9.3 39.6 1.2 8.3 17.0 3.0 1 1 3 4 4 4 0 TMPIT-like protein DUF4763 PF15960.5 OPL21213.1 - 0.65 9.3 37.0 1 8.6 26.0 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) FpoO PF10621.9 OPL21213.1 - 0.68 10.3 6.7 6 7.2 0.8 2.9 1 1 1 2 2 2 0 F420H2 dehydrogenase subunit FpoO HemX PF04375.14 OPL21213.1 - 0.69 9.1 34.7 0.085 12.1 7.6 3.0 1 1 2 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase Wtap PF17098.5 OPL21213.1 - 0.76 9.7 35.0 3.1 7.7 7.3 4.7 1 1 1 3 3 3 0 WTAP/Mum2p family Glyco_hydro_2 PF00703.21 OPL21213.1 - 0.76 10.5 26.5 1.7 9.3 5.9 3.4 1 1 2 3 3 3 0 Glycosyl hydrolases family 2 Exonuc_VII_L PF02601.15 OPL21213.1 - 0.96 9.0 34.4 3.7 7.0 16.8 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit DHR10 PF18595.1 OPL21213.1 - 1.2 9.3 49.6 5.1 7.2 26.1 3.2 1 1 1 2 2 1 0 Designed helical repeat protein 10 domain ERM PF00769.19 OPL21213.1 - 1.4 8.7 46.1 4.3 7.1 21.2 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family UPF0242 PF06785.11 OPL21213.1 - 1.6 8.8 46.0 12 5.9 21.3 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SPATA1_C PF15743.5 OPL21213.1 - 1.7 8.7 51.1 6 6.9 5.5 4.0 1 1 2 3 3 2 0 Spermatogenesis-associated C-terminus PRKG1_interact PF15898.5 OPL21213.1 - 1.8 9.5 46.0 1.8e+04 -19.3 46.0 3.9 1 1 0 1 1 0 0 cGMP-dependent protein kinase interacting domain Lebercilin PF15619.6 OPL21213.1 - 1.8 8.2 51.6 5.2 6.7 27.4 2.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF2163 PF09931.9 OPL21213.1 - 2.5 8.3 5.5 1.5e+02 2.5 4.9 2.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2163) DUF2808 PF10989.8 OPL21213.1 - 2.6 8.0 15.3 4 7.4 8.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2808) Ribosomal_L31 PF01197.18 OPL21213.1 - 2.7 8.3 5.6 1.7e+02 2.5 0.2 3.8 1 1 1 2 2 2 0 Ribosomal protein L31 DUF4200 PF13863.6 OPL21213.1 - 3.1 8.2 51.4 1.7 9.0 21.4 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) DegS PF05384.11 OPL21213.1 - 3.3 7.2 46.2 24 4.4 9.3 4.4 1 1 3 4 4 4 0 Sensor protein DegS FPP PF05911.11 OPL21213.1 - 3.3 5.8 51.2 2.5 6.2 22.7 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil TACC_C PF05010.14 OPL21213.1 - 3.4 7.4 45.0 12 5.7 20.3 2.6 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ADIP PF11559.8 OPL21213.1 - 4.5 7.3 48.3 7.8 6.6 16.7 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Plasmid_RAQPRD PF09686.10 OPL21213.1 - 4.6 7.5 19.7 3.4 7.9 1.1 4.9 1 1 3 4 4 4 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Rx_N PF18052.1 OPL21213.1 - 5.7 7.3 32.4 12 6.2 0.3 5.4 1 1 3 4 4 3 0 Rx N-terminal domain RcpB PF16971.5 OPL21213.1 - 6.1 6.7 19.0 0.26 11.2 6.6 2.7 1 1 2 3 3 3 0 Rough colony protein B, tight adherence - tad - subunit AIP3 PF03915.13 OPL21213.1 - 7.1 5.6 42.0 33 3.4 42.0 1.8 1 1 0 1 1 1 0 Actin interacting protein 3 Glyco_hydro_32C PF08244.12 OPL21213.1 - 7.4 6.5 15.0 6.5e+02 0.2 15.0 2.4 1 1 0 1 1 1 0 Glycosyl hydrolases family 32 C terminal Prp19 PF08606.11 OPL21213.1 - 8.4 6.5 25.3 1.5 8.9 3.5 5.4 2 1 4 6 6 5 0 Prp19/Pso4-like DUF3450 PF11932.8 OPL21213.1 - 8.5 5.6 39.6 4.2 6.6 7.0 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Pih1_fungal_CS PF18482.1 OPL21213.1 - 9.4 6.8 21.1 3.2 8.3 0.9 4.1 1 1 4 5 5 5 0 Fungal Pih1 CS domain TEX13 PF15186.6 OPL21213.1 - 9.5 5.9 35.7 2.7 7.7 7.4 4.1 1 1 3 4 4 4 0 Testis-expressed sequence 13 protein family Glyco_transf_11 PF01531.16 OPL21214.1 - 1.6e-32 112.9 0.5 1.8e-32 112.8 0.5 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 11 O-FucT PF10250.9 OPL21214.1 - 0.00073 19.3 0.0 0.0008 19.2 0.0 1.2 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase PAC4 PF16093.5 OPL21216.1 - 0.13 12.5 0.1 0.17 12.1 0.1 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 DUF1547 PF07577.11 OPL21217.1 - 0.058 13.8 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1547) DUF4980 PF16352.5 OPL21218.1 - 0.018 15.0 0.0 0.048 13.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4980) HTH_42 PF06224.12 OPL21218.1 - 0.077 12.5 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain LSDAT_euk PF18139.1 OPL21219.1 - 1.5e-09 37.7 0.2 2.3e-09 37.0 0.2 1.3 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 OPL21219.1 - 5.5e-06 25.8 0.2 8.3e-06 25.2 0.2 1.4 1 1 0 1 1 1 1 SLOG in TRPM, prokaryote zf-3CxxC_2 PF17180.4 OPL21220.1 - 3.3e-06 27.8 19.9 3e-05 24.7 19.9 2.4 1 1 0 1 1 1 1 Zinc-binding domain zf-3CxxC PF13695.6 OPL21220.1 - 4.8e-06 27.0 14.7 4.3e-05 23.9 14.7 2.0 1 1 0 1 1 1 1 Zinc-binding domain DZR PF12773.7 OPL21220.1 - 0.34 11.0 13.7 31 4.7 13.7 2.2 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 OPL21220.1 - 0.38 10.7 15.7 1.9 8.5 0.4 3.2 2 1 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 OPL21220.1 - 0.82 9.7 12.6 0.42 10.6 5.4 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 OPL21220.1 - 1.1 9.3 13.4 2.1 8.4 6.1 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Fer4_2 PF12797.7 OPL21220.1 - 2 8.7 11.2 30 5.0 0.2 3.3 2 1 0 2 2 2 0 4Fe-4S binding domain zinc_ribbon_2 PF13240.6 OPL21220.1 - 2.2 8.1 13.7 1.7 8.5 0.6 3.2 3 0 0 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 OPL21220.1 - 2.4 8.3 12.8 10 6.4 6.8 2.4 1 1 1 2 2 2 0 Zinc ribbon domain Speriolin_C PF15059.6 OPL21221.1 - 0.011 15.9 0.9 0.015 15.4 0.7 1.2 1 1 0 1 1 1 0 Speriolin C-terminus SLATT_5 PF18160.1 OPL21221.1 - 0.11 11.8 3.0 0.14 11.4 3.0 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 RAI16-like PF10257.9 OPL21223.1 - 3.4e-27 95.3 0.0 3.7e-27 95.2 0.0 1.0 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein MOR2-PAG1_mid PF14228.6 OPL21223.1 - 0.00085 17.1 0.0 0.0009 17.0 0.0 1.0 1 0 0 1 1 1 1 Cell morphogenesis central region RAI16-like PF10257.9 OPL21224.1 - 1.1e-42 146.2 0.2 1.2e-42 146.1 0.2 1.0 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein VOMI PF03762.17 OPL21226.1 - 1.1e-51 175.4 2.3 1.4e-51 175.0 2.3 1.1 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) MIP PF00230.20 OPL21227.1 - 5.5e-26 91.7 5.6 5.8e-23 81.8 0.9 2.1 2 0 0 2 2 2 2 Major intrinsic protein Defensin_big PF14862.6 OPL21228.1 - 0.0044 17.3 0.2 0.0079 16.5 0.2 1.4 1 0 0 1 1 1 1 Big defensin DUF4800 PF16057.5 OPL21229.1 - 0.0029 16.9 0.1 0.0034 16.7 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) 2OG-FeII_Oxy_2 PF13532.6 OPL21230.1 - 8.5e-19 68.5 0.0 1.4e-18 67.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_11 PF08241.12 OPL21230.1 - 6.9e-07 29.8 0.2 0.00031 21.3 0.0 2.7 1 1 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 OPL21230.1 - 0.00014 22.5 0.5 0.022 15.5 0.0 2.8 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 OPL21230.1 - 0.1 12.4 0.0 11 5.8 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Reo_sigmaC PF04582.12 OPL21230.1 - 1 9.6 2.8 1.1 9.5 0.0 2.5 2 1 0 3 3 3 0 Reovirus sigma C capsid protein C-terminal domain C1q PF00386.21 OPL21231.1 - 3.1e-10 40.4 0.0 4e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 C1q domain DUF2405 PF10293.9 OPL21232.1 - 3.9e-09 36.6 0.5 1.9e-08 34.4 0.5 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF2405) T4_tail_cap PF11091.8 OPL21232.1 - 0.022 13.7 0.1 0.032 13.2 0.1 1.2 1 0 0 1 1 1 0 Tail-tube assembly protein Glyco_hydro_38C PF07748.13 OPL21233.1 - 1e-27 97.6 0.0 1.4e-27 97.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Scramblase PF03803.15 OPL21234.1 - 0.00014 21.3 0.0 0.00021 20.7 0.0 1.3 1 0 0 1 1 1 1 Scramblase ADH_N PF08240.12 OPL21235.1 - 2.7e-26 91.6 2.0 4.1e-26 91.0 2.0 1.4 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain HSP70 PF00012.20 OPL21237.1 - 8.4e-06 24.2 0.0 2.7e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Hsp70 protein CARD_2 PF16739.5 OPL21238.1 - 0.00013 21.8 0.0 0.00019 21.4 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain Ank_2 PF12796.7 OPL21239.1 - 1.4e-279 903.6 9.0 2.9e-19 69.4 0.0 21.6 2 1 15 20 20 20 20 Ankyrin repeats (3 copies) Ank_5 PF13857.6 OPL21239.1 - 5.8e-265 851.9 62.3 2.4e-13 50.0 0.1 29.5 4 3 26 33 33 33 33 Ankyrin repeats (many copies) Ank_4 PF13637.6 OPL21239.1 - 2.5e-250 806.0 101.5 1.4e-11 44.7 0.0 38.3 1 1 39 40 40 40 40 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL21239.1 - 8.9e-245 760.0 88.1 2.7e-06 27.3 0.1 40.9 41 0 0 41 41 41 39 Ankyrin repeat Ank PF00023.30 OPL21239.1 - 4.5e-190 608.7 119.3 2.1e-05 24.7 0.0 40.2 40 0 0 40 40 40 37 Ankyrin repeat ArsP_1 PF03773.13 OPL21239.1 - 5.4e-17 61.9 0.2 17 4.5 0.0 16.2 20 0 0 20 20 20 0 Predicted permease SpoIIP PF07454.11 OPL21239.1 - 0.00021 20.8 4.1 1e+02 2.2 0.0 8.3 11 0 0 11 11 11 0 Stage II sporulation protein P (SpoIIP) MOZART1 PF12554.8 OPL21239.1 - 0.00022 21.0 0.0 27 4.6 0.0 8.9 12 0 0 12 12 12 0 Mitotic-spindle organizing gamma-tubulin ring associated PEGA PF08308.11 OPL21239.1 - 0.00045 20.0 11.3 70 3.4 0.0 11.5 13 0 0 13 13 13 0 PEGA domain CdAMP_rec PF06153.11 OPL21239.1 - 0.0019 18.4 43.1 17 5.6 0.1 14.1 9 4 3 16 16 16 0 Cyclic-di-AMP receptor INTS5_C PF14838.6 OPL21239.1 - 0.057 12.0 5.6 46 2.4 0.0 7.4 8 3 2 10 10 10 0 Integrator complex subunit 5 C-terminus Fasciclin PF02469.22 OPL21240.1 - 3.2e-56 189.0 0.0 2.2e-28 99.0 0.0 2.0 2 0 0 2 2 2 2 Fasciclin domain EIIC-GAT PF03611.14 OPL21241.1 - 0.022 13.8 1.3 0.047 12.8 0.3 1.9 2 1 0 2 2 2 0 PTS system sugar-specific permease component VIT PF08487.10 OPL21242.1 - 1.7e-31 108.7 0.5 2.7e-31 108.1 0.5 1.3 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.6 OPL21242.1 - 6.6e-15 54.8 0.1 1.7e-14 53.4 0.1 1.6 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain MRP-S33 PF08293.11 OPL21243.1 - 6.6e-20 71.2 0.7 8.7e-20 70.8 0.7 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Pkinase PF00069.25 OPL21244.1 - 0.0063 15.9 0.1 0.0098 15.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain MCRA PF06100.11 OPL21244.1 - 0.021 13.6 0.3 0.63 8.8 0.1 2.1 2 0 0 2 2 2 0 MCRA family eIF-5a PF01287.20 OPL21245.1 - 2e-22 79.0 5.6 2.9e-22 78.5 5.6 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 OPL21245.1 - 0.0016 18.4 0.0 0.0042 17.1 0.0 1.7 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain PRT_C PF08372.10 OPL21246.1 - 9.7e-07 28.7 3.4 4e-05 23.4 0.0 2.1 1 1 1 2 2 2 2 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 OPL21246.1 - 5.5e-06 26.0 2.4 1.8e-05 24.3 1.5 1.8 1 1 1 2 2 2 1 Plant protein of unknown function (DUF639) Pex24p PF06398.11 OPL21246.1 - 0.00013 21.1 3.9 0.0058 15.7 1.4 2.0 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin DUF3292 PF11696.8 OPL21246.1 - 0.076 11.4 1.2 0.13 10.6 0.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3292) MaAIMP_sms PF16951.5 OPL21246.1 - 2.2 8.1 5.9 0.42 10.4 0.2 2.1 2 0 0 2 2 2 0 Putative methionine and alanine importer, small subunit PAN_1 PF00024.26 OPL21247.1 - 1.5e-06 28.0 0.0 3.6e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 OPL21247.1 - 0.013 15.4 0.2 0.034 14.1 0.2 1.7 1 0 0 1 1 1 0 PAN domain DUF968 PF06147.11 OPL21248.1 - 0.02 15.1 0.2 0.036 14.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF968) DUF4535 PF15054.6 OPL21249.1 - 0.18 11.6 1.0 5.4 6.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4535) NID PF07292.13 OPL21250.1 - 3.7e-05 24.3 0.7 1.6 9.4 0.0 4.1 4 0 0 4 4 4 2 Nmi/IFP 35 domain (NID) RRM_occluded PF16842.5 OPL21250.1 - 0.0059 16.4 0.0 6 6.8 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_1 PF00076.22 OPL21250.1 - 0.0078 16.0 5.0 21 5.0 0.0 4.4 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NCBP3 PF10309.9 OPL21250.1 - 0.013 15.3 0.4 0.084 12.7 0.1 2.4 2 0 0 2 2 2 0 Nuclear cap-binding protein subunit 3 MHB PF16525.5 OPL21250.1 - 0.13 12.6 0.0 13 6.1 0.0 2.4 2 0 0 2 2 2 0 Haemophore, haem-binding OAS1_C PF10421.9 OPL21251.1 - 8.7e-20 71.0 0.1 1.1e-19 70.7 0.1 1.1 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Utp13 PF08625.11 OPL21251.1 - 0.016 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain DUF3688 PF12461.8 OPL21251.1 - 0.028 12.9 0.1 0.032 12.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3688) Thioredoxin PF00085.20 OPL21252.1 - 2.7e-05 24.1 0.1 6.7e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin SCIMP PF15050.6 OPL21252.1 - 0.045 14.2 0.0 0.088 13.3 0.0 1.4 1 0 0 1 1 1 0 SCIMP protein Glutaredoxin PF00462.24 OPL21252.1 - 0.16 12.2 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin DUF2613 PF11021.8 OPL21252.1 - 0.22 11.7 0.1 0.61 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) PDZ PF00595.24 OPL21253.1 - 3.2e-27 94.7 0.2 8.2e-17 61.3 0.2 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 OPL21253.1 - 4.3e-23 80.9 0.0 3.2e-10 39.7 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 OPL21253.1 - 9.6e-16 57.9 0.1 7.4e-07 29.4 0.0 2.3 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 OPL21253.1 - 3.4e-05 23.7 0.1 0.29 11.1 0.1 2.4 2 0 0 2 2 2 2 Tricorn protease PDZ domain PDZ_4 PF17816.1 OPL21253.1 - 0.077 13.4 0.0 10 6.5 0.0 2.7 2 0 0 2 2 2 0 PDZ domain PDZ_1 PF12812.7 OPL21253.1 - 0.086 12.9 0.0 1.2 9.2 0.0 2.6 2 0 0 2 2 2 0 PDZ-like domain zf-C2H2 PF00096.26 OPL21254.1 - 0.00041 20.7 1.4 0.00041 20.7 1.4 2.4 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 OPL21254.1 - 0.0077 16.6 1.2 0.0077 16.6 1.2 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 OPL21254.1 - 0.0079 17.0 1.2 0.0079 17.0 1.2 2.4 3 0 0 3 3 3 1 C2H2-type zinc finger zf-AN1 PF01428.16 OPL21254.1 - 0.024 14.8 7.3 0.066 13.4 7.3 1.8 1 1 0 1 1 1 0 AN1-like Zinc finger XPA_N PF01286.18 OPL21254.1 - 0.035 14.2 0.4 0.035 14.2 0.4 1.7 2 0 0 2 2 2 0 XPA protein N-terminal Spo12 PF05032.12 OPL21254.1 - 1.3 9.0 4.9 12 5.9 0.5 2.7 3 0 0 3 3 3 0 Spo12 family FYDLN_acid PF09538.10 OPL21254.1 - 2.7 8.7 5.7 3.2 8.5 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) ESCRT-II PF05871.12 OPL21255.1 - 6.2e-25 88.1 0.1 8.5e-25 87.6 0.1 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit DUF2555 PF10742.9 OPL21255.1 - 0.052 13.4 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) VWD PF00094.25 OPL21256.1 - 4.1e-06 27.2 0.3 1.2e-05 25.7 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type D domain EGF_2 PF07974.13 OPL21256.1 - 0.00056 20.2 14.5 0.00056 20.2 14.5 2.5 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.7 OPL21256.1 - 0.24 12.1 5.7 1.2 9.8 5.7 2.4 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_Tenascin PF18720.1 OPL21256.1 - 0.72 10.0 22.5 0.043 13.9 15.1 2.5 2 0 0 2 2 2 0 Tenascin EGF domain DNA_primase_S PF01896.19 OPL21257.1 - 7.7e-16 58.6 0.1 1.3e-15 57.9 0.0 1.4 2 0 0 2 2 2 1 DNA primase small subunit PsaM PF07465.13 OPL21258.1 - 0.064 13.0 0.4 0.087 12.6 0.4 1.2 1 0 0 1 1 1 0 Photosystem I protein M (PsaM) C1q PF00386.21 OPL21259.1 - 5.4e-07 29.9 0.1 6.8e-07 29.6 0.1 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL21259.1 - 0.02 14.8 0.2 0.035 14.0 0.2 1.3 1 1 0 1 1 1 0 BclA C-terminal domain Sod_Cu PF00080.20 OPL21260.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Copper/zinc superoxide dismutase (SODC) MFS_1 PF07690.16 OPL21261.1 - 7.7e-30 104.0 2.1 9.1e-30 103.8 2.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 OPL21261.1 - 5.7e-05 22.1 2.9 0.00015 20.8 2.9 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 OPL21261.1 - 0.011 15.1 1.0 0.013 14.9 0.2 1.4 2 0 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB DUF3980 PF13140.6 OPL21261.1 - 1 9.9 4.9 1.4 9.4 1.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3980) Usp PF00582.26 OPL21262.1 - 1.4e-18 67.8 0.0 1.6e-18 67.6 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family UvrB PF12344.8 OPL21264.1 - 0.061 13.2 1.0 0.2 11.6 0.4 1.9 2 0 0 2 2 2 0 Ultra-violet resistance protein B Formyl_trans_N PF00551.19 OPL21265.1 - 2.8e-25 89.1 0.1 6.2e-25 88.0 0.0 1.5 2 0 0 2 2 2 1 Formyl transferase Formyl_trans_C PF02911.18 OPL21265.1 - 0.059 13.6 0.0 0.068 13.4 0.0 1.5 1 1 0 1 1 1 0 Formyl transferase, C-terminal domain AIRS_C PF02769.22 OPL21266.1 - 4.2e-30 104.9 0.1 1.3e-14 54.6 0.0 2.2 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain WHIM1 PF15612.6 OPL21266.1 - 0.093 12.3 21.5 2.4e+02 1.4 0.0 11.9 13 1 1 14 14 14 0 WSTF, HB1, Itc1p, MBD9 motif 1 F-box PF00646.33 OPL21266.1 - 3.2 7.7 17.3 47 4.0 0.1 9.3 12 2 2 14 14 14 0 F-box domain Hydrolase_4 PF12146.8 OPL21267.1 - 7.7e-08 31.9 0.1 8.7e-08 31.7 0.1 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 OPL21267.1 - 6.7e-07 29.2 0.1 7.4e-07 29.1 0.1 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.12 OPL21267.1 - 7.4e-06 24.9 0.1 0.018 13.8 0.0 2.1 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) DUF1057 PF06342.12 OPL21267.1 - 9.3e-06 24.9 0.1 1.1e-05 24.7 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_6 PF12697.7 OPL21267.1 - 3e-05 24.8 0.0 3.1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 OPL21267.1 - 7e-05 22.8 0.2 0.00015 21.7 0.2 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 OPL21267.1 - 0.0012 18.3 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF818 PF05677.12 OPL21267.1 - 0.0026 16.8 0.0 0.0032 16.5 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) BAAT_C PF08840.11 OPL21267.1 - 0.014 15.4 0.0 0.034 14.0 0.0 1.5 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase_3 PF01764.25 OPL21267.1 - 0.029 14.2 0.0 0.029 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.16 OPL21267.1 - 0.032 14.0 0.0 1.4 8.6 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DLH PF01738.18 OPL21267.1 - 0.051 13.1 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydro_lipase PF04083.16 OPL21267.1 - 0.1 12.2 0.1 0.17 11.5 0.1 1.4 1 1 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region PAF-AH_p_II PF03403.13 OPL21267.1 - 0.16 10.5 0.1 0.3 9.5 0.0 1.5 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II RUN PF02759.19 OPL21268.1 - 8.7e-06 25.7 0.0 1.1e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 RUN domain ADAM_spacer1 PF05986.14 OPL21269.1 - 5.5e-26 90.8 0.0 7.3e-26 90.4 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 OPL21269.1 - 0.037 14.2 22.1 0.12 12.6 10.7 2.9 2 1 0 2 2 2 0 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 OPL21270.1 - 0.014 15.9 0.9 0.015 15.8 0.9 1.1 1 0 0 1 1 1 0 ADAM cysteine-rich domain IRS PF02174.17 OPL21271.1 - 2.5e-10 40.1 0.0 9.6e-10 38.3 0.0 2.0 2 0 0 2 2 2 1 PTB domain (IRS-1 type) zf-B_box PF00643.24 OPL21271.1 - 4.7e-07 29.9 28.9 2.9e-05 24.1 5.1 2.6 2 0 0 2 2 2 2 B-box zinc finger DUF3879 PF12995.7 OPL21271.1 - 0.003 17.3 0.4 0.0054 16.5 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3879) HycH PF07450.11 OPL21271.1 - 0.071 13.5 1.9 0.24 11.8 0.0 2.3 1 1 0 2 2 2 0 Formate hydrogenlyase maturation protein HycH PP-binding_2 PF14573.6 OPL21271.1 - 0.082 13.2 0.3 0.64 10.3 0.2 2.4 2 0 0 2 2 2 0 Acyl-carrier vATP-synt_E PF01991.18 OPL21271.1 - 0.096 12.1 10.8 0.042 13.2 8.1 1.7 1 1 1 2 2 2 0 ATP synthase (E/31 kDa) subunit AvrM-A PF18241.1 OPL21271.1 - 0.13 12.7 2.2 0.25 11.7 2.2 1.5 1 0 0 1 1 1 0 Flax-rust effector AvrM-A FYVE PF01363.21 OPL21271.1 - 0.15 12.2 12.9 0.82 9.8 3.0 2.4 2 0 0 2 2 2 0 FYVE zinc finger ACP_PD PF04336.12 OPL21271.1 - 0.41 11.1 1.5 1.2 9.6 0.9 2.0 1 1 0 1 1 1 0 Acyl carrier protein phosphodiesterase DUF4279 PF14106.6 OPL21271.1 - 1.3 9.2 6.4 5.1 7.3 0.5 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4279) Peptidase_S64 PF08192.11 OPL21273.1 - 0.0002 20.0 0.2 0.00047 18.8 0.1 1.6 2 0 0 2 2 2 1 Peptidase family S64 DUF3472 PF11958.8 OPL21273.1 - 0.0022 18.5 0.4 0.0039 17.7 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3472) DUSP PF06337.12 OPL21274.1 - 2.2e-23 82.7 3.9 1.9e-22 79.7 2.3 2.8 2 1 0 2 2 2 1 DUSP domain Ubiquitin_3 PF14836.6 OPL21274.1 - 6.9e-08 32.4 0.3 1.7e-07 31.1 0.3 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain TP6A_N PF04406.14 OPL21274.1 - 0.13 12.3 0.2 0.29 11.1 0.2 1.6 1 0 0 1 1 1 0 Type IIB DNA topoisomerase F5_F8_type_C PF00754.25 OPL21275.1 - 5.1e-10 39.6 0.0 7.4e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain SAM_1 PF00536.30 OPL21276.1 - 0.016 15.6 0.0 0.032 14.7 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 OPL21276.1 - 0.09 12.9 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) bVLRF1 PF18826.1 OPL21277.1 - 7.3e-58 194.7 0.0 1.7e-57 193.5 0.0 1.6 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 OPL21277.1 - 3.5e-07 30.3 0.0 0.00025 21.3 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL21277.1 - 0.0023 18.5 0.0 0.017 15.7 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 OPL21277.1 - 0.056 13.9 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat MAM PF00629.23 OPL21278.1 - 3.9e-10 39.9 1.6 6.4e-10 39.2 1.6 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu DUF5534 PF17686.1 OPL21278.1 - 5.7 7.2 5.6 2.8 8.1 3.6 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5534) MAM PF00629.23 OPL21279.1 - 1e-21 77.5 0.0 1.2e-21 77.3 0.0 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu LRAT PF04970.13 OPL21281.1 - 3e-22 79.3 0.1 3.5e-22 79.1 0.1 1.0 1 0 0 1 1 1 1 Lecithin retinol acyltransferase HycH PF07450.11 OPL21281.1 - 0.095 13.1 0.0 0.11 12.9 0.0 1.1 1 0 0 1 1 1 0 Formate hydrogenlyase maturation protein HycH Dynein_AAA_lid PF17852.1 OPL21282.1 - 3.1e-20 72.6 0.4 4.4e-20 72.1 0.4 1.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_7 PF12775.7 OPL21283.1 - 9.8e-28 96.9 0.0 1.7e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_1 PF17857.1 OPL21283.1 - 1.5e-13 50.8 0.2 4.5e-13 49.3 0.2 1.8 1 0 0 1 1 1 1 AAA+ lid domain Luciferase_3H PF10284.9 OPL21283.1 - 0.12 12.5 0.3 0.56 10.4 0.0 2.3 2 0 0 2 2 2 0 Luciferase helical bundle domain Promethin PF16015.5 OPL21284.1 - 4.6e-22 77.9 7.7 5.2e-22 77.8 7.7 1.1 1 0 0 1 1 1 1 Promethin YlaC PF10777.9 OPL21284.1 - 0.26 11.1 1.2 0.37 10.6 0.7 1.4 1 1 0 1 1 1 0 Inner membrane protein YlaC DUF4191 PF13829.6 OPL21284.1 - 3.8 6.8 5.3 5 6.4 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) TIG PF01833.24 OPL21285.1 - 3.2e-10 39.9 1.9 8.3e-07 29.0 0.4 2.8 3 1 0 3 3 3 2 IPT/TIG domain Sulfotransfer_1 PF00685.27 OPL21286.1 - 2.2e-23 83.1 5.0 2.4e-23 83.0 5.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 OPL21286.1 - 0.00054 20.4 0.1 0.00077 19.9 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family ArsA_HSP20 PF17886.1 OPL21287.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Sld5 PF05916.11 OPL21288.1 - 2.6e-07 31.1 0.1 3.7e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 GINS complex protein KapB PF08810.10 OPL21288.1 - 0.072 13.3 0.0 0.39 10.9 0.0 2.0 2 0 0 2 2 2 0 Kinase associated protein B BssS PF13991.6 OPL21288.1 - 0.13 12.3 0.0 1.8 8.7 0.0 2.2 2 0 0 2 2 2 0 BssS protein family MFS_1 PF07690.16 OPL21289.1 - 1.5e-35 122.7 18.5 2.7e-23 82.4 2.0 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 OPL21289.1 - 0.0021 16.9 14.6 0.081 11.7 2.1 2.3 2 0 0 2 2 2 2 LacY proton/sugar symporter zf-LITAF-like PF10601.9 OPL21289.1 - 3.1 8.1 5.3 0.97 9.8 0.1 2.8 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain HEPN_DZIP3 PF18738.1 OPL21290.1 - 6.4e-29 100.5 0.0 7.5e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN EHN PF06441.12 OPL21292.1 - 0.0013 19.1 0.3 0.0013 19.1 0.3 1.9 2 1 1 3 3 3 1 Epoxide hydrolase N terminus Glyco_hydro_4C PF11975.8 OPL21292.1 - 0.031 14.3 0.5 0.031 14.3 0.5 1.4 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase C-terminal domain RNase_E_G PF10150.9 OPL21292.1 - 0.063 12.7 6.1 1.4 8.2 1.1 2.1 2 0 0 2 2 2 0 Ribonuclease E/G family MRPL52 PF18699.1 OPL21292.1 - 0.13 12.5 0.2 0.13 12.5 0.2 2.6 3 0 0 3 3 3 0 Mitoribosomal protein mL52 Cytomega_UL84 PF06284.11 OPL21292.1 - 0.43 9.0 1.3 0.54 8.7 1.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein CENP-B_dimeris PF09026.10 OPL21292.1 - 0.54 10.7 8.7 2 8.9 8.2 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain HSP70 PF00012.20 OPL21293.1 - 2.6e-12 45.8 0.3 5.8e-05 21.5 0.0 3.0 1 1 1 2 2 2 2 Hsp70 protein StbA PF06406.11 OPL21293.1 - 1.7e-05 24.3 1.1 0.0029 16.9 0.1 2.6 3 0 0 3 3 3 2 StbA protein DDR PF08841.10 OPL21293.1 - 0.078 12.0 2.0 9.5 5.1 0.1 3.2 3 0 0 3 3 3 0 Diol dehydratase reactivase ATPase-like domain DUF4423 PF14394.6 OPL21293.1 - 0.088 12.5 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Spond_N PF06468.13 OPL21293.1 - 0.15 12.2 0.0 25 4.9 0.0 2.4 2 0 0 2 2 2 0 Spondin_N Pkinase PF00069.25 OPL21295.1 - 6.6e-27 94.5 0.0 1.6e-26 93.3 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL21295.1 - 4.2e-12 45.9 0.0 7.2e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase MBT PF02820.18 OPL21296.1 - 2.3e-50 168.8 0.2 1.8e-24 85.9 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SAM_1 PF00536.30 OPL21296.1 - 8.1e-10 39.0 0.2 1.4e-09 38.2 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 OPL21296.1 - 0.00031 20.8 0.0 0.00054 20.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 OPL21296.1 - 0.00073 19.5 0.1 0.0017 18.3 0.1 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 OPL21296.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif HSP70 PF00012.20 OPL21299.1 - 2.7e-05 22.6 0.0 3e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein Ras PF00071.22 OPL21300.1 - 7.4e-39 133.0 0.0 9.9e-39 132.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL21300.1 - 8.9e-13 48.5 0.0 2.9e-12 46.8 0.0 1.8 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 OPL21300.1 - 0.00044 19.8 0.0 0.00061 19.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 OPL21300.1 - 0.0011 18.4 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family HD PF01966.22 OPL21301.1 - 6.3e-10 39.3 2.3 1.4e-09 38.3 2.3 1.5 1 1 0 1 1 1 1 HD domain DUF4371 PF14291.6 OPL21302.1 - 0.022 14.4 0.1 0.025 14.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) Neur_chan_LBD PF02931.23 OPL21303.1 - 3.1e-07 30.1 0.5 3.5e-07 29.9 0.5 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF1996 PF09362.10 OPL21303.1 - 0.0068 16.4 0.1 0.0082 16.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) zf-CCCH_2 PF14608.6 OPL21304.1 - 0.65 10.6 3.6 2.3 8.8 3.6 2.0 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger VASP_tetra PF08776.11 OPL21305.1 - 0.045 13.3 0.3 0.14 11.7 0.1 2.0 2 0 0 2 2 2 0 VASP tetramerisation domain Activator-TraM PF11657.8 OPL21305.1 - 2.6 7.9 6.4 12 5.8 0.4 2.5 2 1 0 2 2 2 0 Transcriptional activator TraM VASP_tetra PF08776.11 OPL21306.1 - 0.075 12.6 0.8 0.16 11.6 0.1 1.9 2 0 0 2 2 2 0 VASP tetramerisation domain Activator-TraM PF11657.8 OPL21306.1 - 2.6 7.9 5.4 15 5.4 0.2 2.3 2 0 0 2 2 2 0 Transcriptional activator TraM Defensin_2 PF01097.18 OPL21308.1 - 4.8e-11 42.4 16.4 9e-11 41.5 16.4 1.5 1 0 0 1 1 1 1 Arthropod defensin Myticin-prepro PF10690.9 OPL21308.1 - 0.0016 18.6 5.1 0.0021 18.2 5.1 1.2 1 0 0 1 1 1 1 Myticin pre-proprotein from the mussel DHC_N2 PF08393.13 OPL21309.1 - 6.7e-35 120.9 4.6 4.3e-20 72.2 0.1 2.0 2 0 0 2 2 2 2 Dynein heavy chain, N-terminal region 2 Neil1-DNA_bind PF09292.10 OPL21310.1 - 2.9e-19 68.7 8.8 4.3e-14 52.2 0.5 2.9 2 1 1 3 3 3 2 Endonuclease VIII-like 1, DNA bind Fapy_DNA_glyco PF01149.24 OPL21310.1 - 4e-10 40.3 0.0 4e-10 40.3 0.0 3.0 2 1 1 3 3 3 1 Formamidopyrimidine-DNA glycosylase N-terminal domain Cu_amine_oxidN1 PF07833.11 OPL21310.1 - 0.24 11.9 1.7 0.37 11.3 0.3 2.0 2 0 0 2 2 2 0 Copper amine oxidase N-terminal domain GREB1 PF15782.5 OPL21310.1 - 0.28 8.3 4.7 0.36 7.9 4.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LAP1C PF05609.12 OPL21310.1 - 2.5 7.1 15.2 0.18 10.9 9.9 1.6 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) PEN-2 PF10251.9 OPL21311.1 - 3.4e-14 53.0 4.8 1.1e-12 48.2 1.8 2.0 1 1 1 2 2 2 2 Presenilin enhancer-2 subunit of gamma secretase Mab-21 PF03281.14 OPL21313.1 - 3.9e-15 55.9 0.1 8.6e-15 54.8 0.0 1.5 2 0 0 2 2 2 1 Mab-21 protein Exo_endo_phos PF03372.23 OPL21320.1 - 1.4e-06 28.1 0.0 1.5e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BRI3BP PF14965.6 OPL21321.1 - 0.055 13.0 0.7 0.068 12.7 0.7 1.1 1 0 0 1 1 1 0 Negative regulator of p53/TP53 I-set PF07679.16 OPL21322.1 - 1.1e-14 54.3 0.1 1.4e-14 53.9 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL21322.1 - 6.6e-11 42.7 0.0 9.8e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 OPL21322.1 - 4.4e-07 30.0 0.1 5.6e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL21322.1 - 2.7e-06 27.6 0.1 8.2e-06 26.1 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_4 PF16680.5 OPL21322.1 - 0.0033 17.7 0.8 0.11 12.8 0.2 2.2 1 1 1 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 OPL21322.1 - 0.052 13.1 0.0 0.08 12.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Ig_5 PF16681.5 OPL21322.1 - 0.073 13.5 0.2 0.35 11.3 0.2 2.0 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 OPL21322.1 - 0.089 12.9 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Kazal_1 PF00050.21 OPL21324.1 - 9.6e-18 63.9 35.2 5.9e-07 29.4 8.8 3.8 1 1 2 3 3 3 3 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 OPL21324.1 - 3.2e-09 36.8 45.7 0.03 14.4 15.5 4.5 3 1 1 4 4 4 3 Kazal-type serine protease inhibitor domain Metallothio_5 PF02067.15 OPL21324.1 - 6.1 7.1 53.7 0.37 10.9 14.9 3.6 3 1 0 3 3 3 0 Metallothionein family 5 ABC_tran PF00005.27 OPL21325.1 - 1.7e-33 116.1 0.0 2.5e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 OPL21325.1 - 3.5e-09 36.4 2.0 2.4e-07 30.4 0.3 2.2 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 OPL21325.1 - 0.00043 19.6 0.0 0.025 13.9 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 OPL21325.1 - 0.00047 20.5 0.1 0.003 17.8 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 OPL21325.1 - 0.0016 18.8 0.2 0.0044 17.4 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 OPL21325.1 - 0.0021 17.8 0.4 0.013 15.2 0.2 2.3 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 OPL21325.1 - 0.0038 17.0 0.1 0.15 11.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 OPL21325.1 - 0.0057 16.6 0.3 0.026 14.4 0.1 2.1 1 1 1 2 2 2 1 RsgA GTPase IstB_IS21 PF01695.17 OPL21325.1 - 0.011 15.5 0.5 1.1 8.9 0.1 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_15 PF13175.6 OPL21325.1 - 0.012 15.3 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ABC_ATPase PF09818.9 OPL21325.1 - 0.016 14.0 0.2 0.052 12.3 0.2 1.7 2 0 0 2 2 2 0 Predicted ATPase of the ABC class G-alpha PF00503.20 OPL21325.1 - 0.02 14.0 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit SbcCD_C PF13558.6 OPL21325.1 - 0.024 14.8 0.7 0.51 10.6 0.7 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA PF00004.29 OPL21325.1 - 0.029 14.8 2.1 0.85 10.1 2.1 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 OPL21325.1 - 0.03 14.0 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.17 OPL21325.1 - 0.037 14.1 0.2 11 6.0 0.2 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_21 PF13304.6 OPL21325.1 - 0.043 13.6 0.3 5.4 6.7 0.1 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 OPL21325.1 - 0.043 13.8 0.0 0.47 10.4 0.0 2.3 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 OPL21325.1 - 0.05 13.5 0.0 3 7.7 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain RNA_helicase PF00910.22 OPL21325.1 - 0.19 12.1 0.3 1.1 9.7 0.1 2.3 2 1 1 3 3 3 0 RNA helicase Ank_2 PF12796.7 OPL21326.1 - 1.3e-21 77.0 8.8 3e-09 37.4 0.5 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL21326.1 - 7.1e-18 64.7 4.1 2e-05 25.1 0.1 4.6 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 OPL21326.1 - 1.1e-15 57.4 4.2 6e-06 26.4 0.1 4.4 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 OPL21326.1 - 1.4e-14 53.8 7.6 6.8e-06 26.3 0.2 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 OPL21326.1 - 1.5e-13 49.6 3.6 0.0072 16.8 0.0 5.8 6 0 0 6 6 6 3 Ankyrin repeat Ank_2 PF12796.7 OPL21327.1 - 3.5e-19 69.2 0.1 7.6e-18 64.9 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 OPL21327.1 - 2.9e-15 55.9 1.1 0.00069 19.9 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 OPL21327.1 - 3.1e-14 51.7 0.1 0.0024 18.2 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 OPL21327.1 - 6.1e-14 52.2 0.5 1.6e-05 25.4 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 OPL21327.1 - 1.2e-11 44.6 0.4 2.6e-07 30.8 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL21328.1 - 2.2e-12 47.4 0.0 2.7e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL21328.1 - 1.9e-11 44.2 0.6 6e-09 36.3 0.1 2.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 OPL21328.1 - 1.3e-10 41.3 0.2 5.4e-09 36.1 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 OPL21328.1 - 1.9e-09 37.6 0.2 1.6e-07 31.4 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 OPL21328.1 - 7.4e-08 32.1 0.1 0.0001 22.4 0.0 2.5 3 0 0 3 3 3 2 Ankyrin repeat Plasmid_RAQPRD PF09686.10 OPL21328.1 - 0.15 12.3 0.3 1.2 9.4 0.3 1.9 1 1 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) RabGAP-TBC PF00566.18 OPL21329.1 - 4.8e-09 36.2 0.2 1.2e-08 34.9 0.0 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Neur_chan_LBD PF02931.23 OPL21330.1 - 2e-30 105.8 0.1 2.5e-30 105.5 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 OPL21330.1 - 0.18 11.8 0.8 3.4 7.7 0.1 2.1 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Y_phosphatase PF00102.27 OPL21331.1 - 2.5e-30 105.8 1.4 4.3e-30 105.0 1.4 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase EphA2_TM PF14575.6 OPL21331.1 - 0.0048 17.8 0.3 0.0086 16.9 0.3 1.8 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF2613 PF11021.8 OPL21331.1 - 0.019 15.1 0.2 0.039 14.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) DUF1616 PF07760.11 OPL21331.1 - 0.06 12.7 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) Arm PF00514.23 OPL21332.1 - 1.9e-10 40.4 0.0 0.00019 21.4 0.0 3.2 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 OPL21332.1 - 4e-05 23.2 2.4 0.0017 17.9 2.3 2.2 1 1 0 1 1 1 1 Armadillo-like DUF3361 PF11841.8 OPL21332.1 - 0.0059 16.6 1.2 0.0073 16.3 0.3 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) RICTOR_V PF14668.6 OPL21332.1 - 0.016 15.4 0.1 2.4 8.5 0.1 2.4 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_N PF03224.14 OPL21332.1 - 0.02 14.2 0.7 0.12 11.6 0.7 2.1 1 1 0 1 1 1 0 V-ATPase subunit H DUF5578 PF17741.1 OPL21332.1 - 0.021 14.2 0.5 0.024 14.0 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5578) UNC45-central PF11701.8 OPL21332.1 - 0.041 13.9 0.4 0.083 12.9 0.2 1.7 1 1 0 1 1 1 0 Myosin-binding striated muscle assembly central Tn7_Tnp_TnsA_C PF08721.11 OPL21332.1 - 0.066 13.9 0.4 8.4 7.1 0.1 3.0 1 1 2 3 3 3 0 TnsA endonuclease C terminal DUF937 PF06078.11 OPL21332.1 - 0.087 13.4 0.0 0.098 13.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF937) DUF61 PF01886.16 OPL21332.1 - 0.12 12.4 2.7 0.85 9.7 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF61 IRK_C PF17655.1 OPL21333.1 - 4.9e-75 250.9 0.0 7.7e-75 250.3 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 OPL21333.1 - 1.9e-62 209.3 1.8 2.9e-62 208.7 1.8 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 OPL21333.1 - 0.00021 21.2 0.6 0.00036 20.4 0.6 1.4 1 0 0 1 1 1 1 Ion channel FG-GAP PF01839.23 OPL21334.1 - 2e-16 59.8 12.8 6.8e-08 32.5 4.4 3.5 4 0 0 4 4 4 2 FG-GAP repeat VCBS PF13517.6 OPL21334.1 - 9.4e-10 38.9 5.5 0.0001 22.8 0.2 2.5 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 OPL21334.1 - 0.0022 18.2 9.8 0.83 10.0 0.1 3.7 4 0 0 4 4 4 2 FG-GAP repeat HisK_sensor PF18698.1 OPL21334.1 - 0.051 14.0 0.2 0.63 10.4 0.0 2.3 2 0 0 2 2 2 0 Histidine kinase sensor domain HMMR_N PF15905.5 OPL21335.1 - 0.015 14.8 1.8 0.021 14.3 0.5 1.7 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF4686 PF15742.5 OPL21335.1 - 0.02 14.0 1.3 0.033 13.3 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) TSC22 PF01166.18 OPL21335.1 - 0.021 15.1 1.8 0.12 12.7 0.1 2.4 2 1 0 2 2 2 0 TSC-22/dip/bun family CdvA PF18822.1 OPL21335.1 - 0.021 14.6 2.5 2.9 7.7 0.9 2.2 2 0 0 2 2 2 0 CdvA-like coiled-coil domain YabA PF06156.13 OPL21335.1 - 0.027 15.1 0.5 0.23 12.1 0.2 2.1 2 0 0 2 2 2 0 Initiation control protein YabA FliD_N PF02465.18 OPL21335.1 - 0.028 15.1 0.0 1.8 9.3 0.1 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus TPR_MLP1_2 PF07926.12 OPL21335.1 - 0.051 13.6 2.7 0.41 10.7 0.5 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein HAP1_N PF04849.13 OPL21335.1 - 0.078 12.2 2.8 0.54 9.4 0.7 2.0 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Sec2p PF06428.11 OPL21335.1 - 0.079 12.9 3.3 0.14 12.2 1.4 2.1 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF3972 PF13118.6 OPL21335.1 - 0.081 13.4 0.8 0.13 12.7 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) DUF1664 PF07889.12 OPL21335.1 - 0.084 12.9 1.2 6.9 6.7 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SOGA PF11365.8 OPL21335.1 - 0.11 13.6 0.9 0.11 13.6 0.9 1.9 2 0 0 2 2 2 0 Protein SOGA Csm1_N PF18504.1 OPL21335.1 - 0.11 12.8 4.6 5.6 7.4 1.4 2.9 2 1 1 3 3 3 0 Csm1 N-terminal domain YkyA PF10368.9 OPL21335.1 - 0.35 10.5 4.2 0.28 10.9 1.4 1.9 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Tropomyosin_1 PF12718.7 OPL21335.1 - 0.45 10.7 7.8 3.3 7.9 1.8 2.2 2 0 0 2 2 2 0 Tropomyosin like ATG16 PF08614.11 OPL21335.1 - 0.69 10.1 6.0 0.72 10.0 3.5 1.9 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) PspB PF06667.12 OPL21335.1 - 1.2 9.3 3.1 2.6 8.2 0.7 2.2 2 0 0 2 2 2 0 Phage shock protein B Atg14 PF10186.9 OPL21335.1 - 1.2 8.1 5.4 4.1 6.4 5.6 1.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 OPL21335.1 - 1.5 8.6 4.3 9.1 6.1 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Helicase_C PF00271.31 OPL21336.1 - 3.1e-14 53.2 0.0 1.4e-13 51.1 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RIG-I_C PF18119.1 OPL21336.1 - 3.4e-06 27.1 0.4 9.4e-06 25.7 0.3 1.9 1 1 0 1 1 1 1 RIG-I receptor C-terminal domain ResIII PF04851.15 OPL21336.1 - 6.5e-06 26.3 0.0 3.4e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 OPL21336.1 - 0.00049 19.9 0.0 0.003 17.3 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase RIG-I_C-RD PF11648.8 OPL21336.1 - 0.011 16.0 0.3 0.4 10.9 0.1 2.5 2 0 0 2 2 2 0 C-terminal domain of RIG-I ET PF01684.16 OPL21336.1 - 0.16 12.3 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 ET module Ribosomal_L24e PF01246.20 OPL21336.1 - 0.47 10.7 4.6 10 6.4 0.0 3.6 4 0 0 4 4 4 0 Ribosomal protein L24e Prenyltrans PF00432.21 OPL21337.1 - 0.069 12.9 0.0 0.08 12.7 0.0 1.4 1 1 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat BIR PF00653.21 OPL21338.1 - 5.1e-31 107.1 6.8 4e-18 65.8 0.2 3.2 3 0 0 3 3 3 2 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 OPL21338.1 - 1.8e-11 43.7 10.6 1.8e-11 43.7 10.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL21338.1 - 0.00046 20.0 10.5 0.00046 20.0 10.5 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 OPL21338.1 - 0.056 13.8 12.5 0.28 11.6 12.5 2.3 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 OPL21338.1 - 0.8 9.7 15.4 0.16 12.0 10.8 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Tir_receptor_N PF07490.11 OPL21338.1 - 5.8 6.7 10.1 1.7 8.4 2.0 2.4 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) N-terminus Ldl_recept_a PF00057.18 OPL21339.1 - 9.2e-07 29.0 8.2 9.2e-07 29.0 8.2 1.8 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A TMIE PF16038.5 OPL21339.1 - 0.052 13.4 0.1 0.094 12.6 0.1 1.5 1 0 0 1 1 1 0 TMIE protein Bee_toxin PF17454.2 OPL21339.1 - 0.86 9.7 5.3 0.11 12.6 0.8 1.8 2 0 0 2 2 2 0 Honey bee toxin CMAS PF02353.20 OPL21340.1 - 4.6e-10 39.3 0.1 7.5e-10 38.6 0.1 1.4 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase BIR PF00653.21 OPL21341.1 - 1e-20 74.1 0.1 1e-20 74.1 0.1 2.6 2 1 1 3 3 3 1 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 OPL21341.1 - 5.5e-10 39.0 8.1 7.4e-10 38.5 6.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL21341.1 - 0.0002 21.2 7.6 0.00048 19.9 7.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_7 PF02591.15 OPL21341.1 - 0.32 11.2 2.8 20 5.4 0.0 3.3 3 0 0 3 3 3 0 C4-type zinc ribbon domain Vps39_2 PF10367.9 OPL21341.1 - 0.95 9.9 4.5 0.13 12.7 0.5 1.7 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 DUF3176 PF11374.8 OPL21342.1 - 0.02 15.1 0.3 0.026 14.7 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3176) ApoC-I PF04691.12 OPL21343.1 - 0.004 17.0 0.1 0.086 12.8 0.0 2.9 3 0 0 3 3 3 1 Apolipoprotein C-I (ApoC-1) Ion_trans PF00520.31 OPL21344.1 - 3.3e-08 33.1 8.4 3.6e-08 33.0 8.4 1.1 1 0 0 1 1 1 1 Ion transport protein DUF423 PF04241.15 OPL21344.1 - 1.2 9.4 3.7 4.4 7.6 2.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF423) Ldl_recept_b PF00058.17 OPL21345.1 - 3.2e-09 37.1 1.4 4.5e-08 33.5 0.2 2.3 2 0 0 2 2 2 1 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 OPL21345.1 - 2.7e-08 33.9 7.2 4.6e-08 33.2 7.2 1.4 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site cEGF PF12662.7 OPL21345.1 - 0.00016 21.5 0.8 0.00036 20.4 0.8 1.7 1 0 0 1 1 1 1 Complement Clr-like EGF-like EGF PF00008.27 OPL21345.1 - 0.076 13.3 6.5 0.2 12.0 6.5 1.7 1 0 0 1 1 1 0 EGF-like domain TIL PF01826.17 OPL21345.1 - 0.13 12.6 2.8 0.26 11.6 2.8 1.4 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain RabGAP-TBC PF00566.18 OPL21346.1 - 5.9e-26 91.5 0.0 9.7e-26 90.7 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 OPL21346.1 - 6.7e-10 38.9 0.0 1.4e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Insulin_TMD PF17870.1 OPL21347.1 - 0.24 11.5 3.1 0.61 10.2 3.1 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DZR PF12773.7 OPL21348.1 - 2.4e-09 37.0 13.4 2e-06 27.7 7.3 2.5 2 0 0 2 2 2 2 Double zinc ribbon zinc_ribbon_2 PF13240.6 OPL21348.1 - 2.9e-06 26.8 21.8 0.015 15.0 2.1 3.7 3 0 0 3 3 3 3 zinc-ribbon domain zf-NADH-PPase PF09297.11 OPL21348.1 - 0.0072 16.0 1.8 0.0072 16.0 1.8 3.2 3 0 0 3 3 3 1 NADH pyrophosphatase zinc ribbon domain DUF2574 PF10836.8 OPL21348.1 - 0.04 13.8 0.6 0.32 10.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2574) zinc_ribbon_15 PF17032.5 OPL21348.1 - 0.16 12.7 20.9 0.48 11.2 1.6 4.2 3 0 0 3 3 3 0 zinc-ribbon family zf-TRM13_CCCH PF11722.8 OPL21348.1 - 0.23 11.3 7.4 11 5.9 0.7 3.6 3 0 0 3 3 3 0 CCCH zinc finger in TRM13 protein zf-ribbon_3 PF13248.6 OPL21348.1 - 0.49 9.9 21.5 0.79 9.2 1.7 3.9 3 1 0 3 3 3 0 zinc-ribbon domain UPF0547 PF10571.9 OPL21348.1 - 0.75 9.9 19.5 0.8 9.8 1.9 3.5 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 DHHC PF01529.20 OPL21348.1 - 0.77 9.9 2.7 16 5.6 1.4 2.5 1 1 1 2 2 2 0 DHHC palmitoyltransferase Nudix_N_2 PF14803.6 OPL21348.1 - 2.6 8.0 13.3 5.7 7.0 2.0 3.7 3 0 0 3 3 3 0 Nudix N-terminal DENN PF02141.21 OPL21349.1 - 3.3e-53 180.4 6.4 6e-53 179.6 6.4 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 OPL21349.1 - 3.6e-18 65.3 0.6 3.6e-18 65.3 0.6 2.3 2 0 0 2 2 2 1 dDENN domain uDENN PF03456.18 OPL21349.1 - 5.4e-07 30.3 0.1 1.6e-06 28.8 0.1 1.9 1 0 0 1 1 1 1 uDENN domain Lectin_C PF00059.21 OPL21350.1 - 5.1e-14 52.9 5.2 6e-14 52.7 5.2 1.1 1 0 0 1 1 1 1 Lectin C-type domain Death PF00531.22 OPL21351.1 - 0.00029 20.9 0.1 0.00064 19.8 0.1 1.6 1 0 0 1 1 1 1 Death domain Fer4_23 PF18009.1 OPL21351.1 - 0.063 13.7 0.2 0.16 12.4 0.2 1.6 1 0 0 1 1 1 0 4Fe-4S iron-sulfur cluster binding domain TIR PF01582.20 OPL21352.1 - 1.5e-13 51.0 0.1 3.1e-13 49.9 0.1 1.5 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 OPL21352.1 - 8.4e-12 45.7 0.0 2.2e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 TIR domain Phage_TAC_12 PF12363.8 OPL21352.1 - 0.028 14.8 0.3 0.081 13.3 0.1 1.8 1 1 0 2 2 2 0 Phage tail assembly chaperone protein, TAC PABP PF00658.18 OPL21353.1 - 4.9e-21 74.7 1.3 5.8e-20 71.2 0.2 2.4 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain TIMP PF00965.17 OPL21354.1 - 1.1e-11 44.8 0.8 1.6e-11 44.4 0.8 1.2 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase DHNA PF04038.12 OPL21356.1 - 0.18 12.4 0.0 0.3 11.6 0.0 1.4 1 0 0 1 1 1 0 Dihydroneopterin aldolase Sec7_N PF12783.7 OPL21357.1 - 2.9e-05 24.0 0.1 4.6e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF4045 PF13254.6 OPL21357.1 - 0.0027 17.4 8.9 0.0034 17.1 8.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4045) DUF1045 PF06299.12 OPL21357.1 - 0.0068 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1045) Plasmodium_Vir PF05795.11 OPL21357.1 - 7.7 5.8 7.5 15 4.8 7.4 1.6 1 1 0 1 1 1 0 Plasmodium vivax Vir protein F-box-like PF12937.7 OPL21358.1 - 1.9e-06 27.7 0.4 4.9e-06 26.3 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 OPL21358.1 - 1.2e-05 25.1 0.3 1.2e-05 25.1 0.3 2.1 3 0 0 3 3 3 1 F-box domain IBR PF01485.21 OPL21358.1 - 9.1e-05 22.6 6.6 9.1e-05 22.6 6.6 2.4 3 0 0 3 3 3 1 IBR domain, a half RING-finger domain ARTD15_N PF18084.1 OPL21358.1 - 0.025 14.8 0.0 0.072 13.3 0.0 1.8 1 0 0 1 1 1 0 ARTD15 N-terminal domain MAM PF00629.23 OPL21360.1 - 3.7e-55 186.2 6.5 4.9e-26 91.6 0.2 4.0 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu Roc PF08477.13 OPL21362.1 - 3.3e-07 30.6 1.7 5.8e-07 29.7 0.3 2.2 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 OPL21362.1 - 5.8e-05 23.0 0.1 0.00017 21.4 0.0 1.8 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain SH3_1 PF00018.28 OPL21363.1 - 0.00032 20.2 0.2 0.00067 19.2 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 OPL21363.1 - 0.02 14.7 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.17 OPL21363.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain MRFAP1 PF15155.6 OPL21363.1 - 0.26 11.8 11.3 1 9.9 0.2 3.5 2 2 1 3 3 3 0 MORF4 family-associated protein1 Lectin_N PF03954.14 OPL21363.1 - 0.74 9.6 7.7 0.25 11.1 3.1 2.3 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF4404 PF14357.6 OPL21363.1 - 2.1 9.0 9.0 0.26 12.0 1.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) CHD5 PF04420.14 OPL21363.1 - 2.3 8.0 11.9 1.3 8.8 8.9 2.1 2 0 0 2 2 2 0 CHD5-like protein AATF-Che1 PF13339.6 OPL21363.1 - 9.3 6.9 15.2 8.3 7.1 8.2 3.1 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor START PF01852.19 OPL21364.1 - 3.2e-08 33.3 0.0 4.8e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 START domain EGF_3 PF12947.7 OPL21367.1 - 0.0014 18.8 5.0 0.0014 18.8 5.0 2.8 3 1 0 3 3 3 2 EGF domain EB PF01683.18 OPL21367.1 - 0.0018 18.6 6.1 0.0018 18.6 6.1 2.2 1 1 1 2 2 2 1 EB module RANK_CRD_2 PF18278.1 OPL21367.1 - 0.023 14.8 2.4 4 7.7 0.4 2.6 2 0 0 2 2 2 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 HTH_10 PF04967.12 OPL21367.1 - 0.029 14.2 0.0 0.59 10.0 0.0 2.1 2 0 0 2 2 2 0 HTH DNA binding domain hEGF PF12661.7 OPL21367.1 - 0.039 14.6 12.4 0.28 11.9 1.9 3.8 4 0 0 4 4 4 0 Human growth factor-like EGF cEGF PF12662.7 OPL21367.1 - 0.054 13.4 16.2 0.55 10.2 2.7 2.6 2 1 0 2 2 2 0 Complement Clr-like EGF-like ISP1_C PF18161.1 OPL21367.1 - 0.11 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 ISP1 C-terminal Scs3p PF10261.9 OPL21367.1 - 0.12 11.8 1.6 0.13 11.7 1.6 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM EGF_CA PF07645.15 OPL21367.1 - 2.2 8.5 13.1 5.4 7.3 5.8 2.5 2 1 0 2 2 2 0 Calcium-binding EGF domain Plasmod_Pvs28 PF06247.11 OPL21367.1 - 2.4 8.5 15.8 18 5.8 0.3 3.0 2 1 0 2 2 2 0 Pvs28 EGF domain EGF PF00008.27 OPL21367.1 - 3.2 8.2 15.5 0.16 12.3 1.4 3.0 4 1 0 4 4 3 0 EGF-like domain GDP_Man_Dehyd PF16363.5 OPL21368.1 - 2.6e-12 46.8 0.0 3.3e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 OPL21368.1 - 1.1e-11 44.7 0.0 1.4e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 OPL21368.1 - 0.13 11.3 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Peptidase_C48 PF02902.19 OPL21369.1 - 0.004 17.0 0.0 0.0067 16.3 0.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain zf-C2HC_2 PF13913.6 OPL21369.1 - 0.036 14.0 0.9 0.036 14.0 0.9 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-Dof PF02701.15 OPL21369.1 - 0.14 12.3 6.4 0.36 11.0 6.4 1.7 1 1 0 1 1 1 0 Dof domain, zinc finger Zf_RING PF16744.5 OPL21369.1 - 0.34 11.0 11.0 4 7.6 11.4 2.1 1 1 1 2 2 2 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 OPL21369.1 - 4.5 7.3 13.4 0.61 10.1 5.8 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 SNF2_N PF00176.23 OPL21370.1 - 4.1e-36 124.4 0.8 5.8e-36 123.9 0.8 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain CLTH PF10607.9 OPL21370.1 - 0.088 12.7 2.3 0.15 11.9 2.3 1.5 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain TNF PF00229.18 OPL21376.1 - 5.9e-08 32.7 0.4 1e-07 31.9 0.0 1.6 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family OSTMP1 PF09777.9 OPL21376.1 - 3.8 6.8 7.9 0.3 10.5 0.8 2.5 2 2 0 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor ThiF PF00899.21 OPL21377.1 - 6.7e-14 51.8 0.0 7.5e-14 51.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family Hydantoinase_A PF01968.18 OPL21377.1 - 0.085 12.1 0.0 0.6 9.3 0.0 1.9 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase E1_DerP2_DerF2 PF02221.15 OPL21378.1 - 2.7e-17 63.4 0.1 3.5e-17 63.1 0.1 1.1 1 0 0 1 1 1 1 ML domain Ank_2 PF12796.7 OPL21380.1 - 1.3e-32 112.2 0.4 3e-17 63.0 0.1 2.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL21380.1 - 5.1e-21 74.8 0.4 3.5e-10 40.2 0.0 3.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL21380.1 - 1.5e-18 64.9 0.2 0.0027 18.1 0.0 4.2 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 OPL21380.1 - 4e-17 62.1 1.0 0.00024 21.3 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 OPL21380.1 - 6.2e-17 61.2 0.2 0.0008 19.7 0.0 4.2 4 0 0 4 4 4 4 Ankyrin repeat M20_dimer PF07687.14 OPL21381.1 - 8.8e-09 35.3 0.0 1.2e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase dimerisation domain Transglut_core PF01841.19 OPL21382.1 - 0.0018 18.7 0.0 0.0041 17.5 0.0 1.6 1 1 0 1 1 1 1 Transglutaminase-like superfamily HSP70 PF00012.20 OPL21383.1 - 2.4e-11 42.5 0.1 6.2e-10 37.9 0.1 2.1 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL21383.1 - 0.032 13.0 0.5 2.1 7.1 0.1 2.4 2 0 0 2 2 2 0 MreB/Mbl protein DeoC PF01791.9 OPL21383.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 DeoC/LacD family aldolase CHB_HEX_C_1 PF13290.6 OPL21384.1 - 1.9e-10 40.6 0.0 4.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 OPL21384.1 - 1.5e-05 25.1 0.0 3.7e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Fn3 associated fn3 PF00041.21 OPL21384.1 - 0.013 15.9 0.0 1.1 9.7 0.0 2.7 2 1 0 2 2 2 0 Fibronectin type III domain ShK PF01549.24 OPL21385.1 - 7.2e-07 29.6 20.1 0.0021 18.5 4.4 2.4 2 0 0 2 2 2 2 ShK domain-like DUF4119 PF13494.6 OPL21386.1 - 0.0096 16.0 1.7 0.013 15.6 0.6 1.9 2 1 0 2 2 2 1 Domain of unknown function, B. Theta Gene description (DUF4119) DUF16 PF01519.16 OPL21386.1 - 1.7 9.1 8.7 13 6.3 8.6 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF5383 PF17355.2 OPL21386.1 - 6.7 7.1 10.7 0.43 11.0 0.2 3.0 2 1 2 4 4 4 0 Family of unknown function (DUF5383) Helicase_C PF00271.31 OPL21387.1 - 6.2e-19 68.4 0.0 1.3e-18 67.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 OPL21387.1 - 0.0024 17.1 1.1 0.0064 15.7 0.2 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 MFS_1 PF07690.16 OPL21389.1 - 6.4e-23 81.2 4.2 1.1e-21 77.2 3.3 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4118 PF13493.6 OPL21389.1 - 1 9.2 7.4 0.18 11.6 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) IncF PF17626.2 OPL21389.1 - 2.3 8.6 5.4 2 8.8 0.6 2.6 3 0 0 3 3 3 0 Inclusion membrane protein F EF-hand_7 PF13499.6 OPL21390.1 - 1.6e-06 28.5 0.7 3.3e-06 27.4 0.7 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 OPL21390.1 - 1.1e-05 24.9 1.5 0.0056 16.5 0.5 2.5 2 0 0 2 2 2 2 EF-hand domain AAA PF00004.29 OPL21390.1 - 6.7e-05 23.3 0.0 7.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) EF-hand_1 PF00036.32 OPL21390.1 - 0.00019 20.7 8.6 0.039 13.5 0.4 2.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 OPL21390.1 - 0.0075 16.1 2.6 0.013 15.4 1.3 2.0 1 1 1 2 2 2 1 EF-hand domain pair NRBF2 PF08961.10 OPL21390.1 - 0.068 12.8 0.1 0.083 12.5 0.1 1.1 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator EF-hand_5 PF13202.6 OPL21390.1 - 5.6 6.6 6.2 1.1 8.9 0.3 2.5 2 1 0 2 2 2 0 EF hand VOMI PF03762.17 OPL21391.1 - 1.1e-32 113.5 0.3 1.4e-32 113.2 0.3 1.1 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) DSPc PF00782.20 OPL21392.1 - 4.8e-14 52.3 4.1 4.2e-12 46.0 0.0 3.1 2 1 1 3 3 3 2 Dual specificity phosphatase, catalytic domain DUF596 PF04591.12 OPL21392.1 - 0.066 13.4 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF596 DUF4817 PF16087.5 OPL21392.1 - 0.07 12.9 0.1 0.26 11.1 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) HEPN_DZIP3 PF18738.1 OPL21393.1 - 0.00062 19.5 0.1 0.001 18.8 0.1 1.4 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN DUF72 PF01904.18 OPL21393.1 - 0.022 14.9 0.1 0.51 10.4 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF72 HisKA_2 PF07568.12 OPL21393.1 - 0.027 14.5 0.6 0.049 13.7 0.6 1.4 1 0 0 1 1 1 0 Histidine kinase PG_binding_4 PF12229.8 OPL21393.1 - 0.031 14.6 0.6 0.04 14.2 0.6 1.2 1 0 0 1 1 1 0 Putative peptidoglycan binding domain TBCC_N PF16752.5 OPL21393.1 - 0.082 13.4 2.8 3.1 8.3 0.2 2.2 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain PLC-beta_C PF08703.10 OPL21393.1 - 0.11 12.5 4.4 0.4 10.6 4.7 1.7 1 1 1 2 2 2 0 PLC-beta C terminal AAA_11 PF13086.6 OPL21394.1 - 0.00063 19.6 0.0 0.00087 19.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 OPL21394.1 - 0.00069 18.9 0.0 0.00075 18.8 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_19 PF13245.6 OPL21394.1 - 0.029 14.7 0.0 0.045 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 OPL21394.1 - 0.061 13.3 0.0 0.094 12.7 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AIP3 PF03915.13 OPL21395.1 - 0.0067 15.6 3.4 0.007 15.5 3.4 1.0 1 0 0 1 1 1 1 Actin interacting protein 3 CENP-B_N PF04218.13 OPL21395.1 - 0.013 15.1 0.4 0.028 14.1 0.4 1.6 1 1 0 1 1 1 0 CENP-B N-terminal DNA-binding domain AAA_11 PF13086.6 OPL21395.1 - 0.013 15.3 2.6 0.013 15.3 2.6 1.0 1 0 0 1 1 1 0 AAA domain DUF1542 PF07564.11 OPL21395.1 - 0.038 14.1 7.7 0.049 13.7 7.6 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1542) Ketoacyl-synt_C PF02801.22 OPL21395.1 - 0.04 13.9 0.2 0.045 13.8 0.2 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain Mago_nashi PF02792.14 OPL21395.1 - 0.057 13.5 2.2 0.064 13.4 2.2 1.1 1 0 0 1 1 1 0 Mago nashi protein MmgE_PrpD PF03972.14 OPL21395.1 - 0.084 11.4 0.6 0.093 11.3 0.6 1.0 1 0 0 1 1 1 0 MmgE/PrpD family SpoOE-like PF09388.10 OPL21395.1 - 1.6 8.7 6.6 9.4 6.2 5.6 2.6 2 1 0 2 2 2 0 Spo0E like sporulation regulatory protein PLA2_B PF01735.18 OPL21396.1 - 2.6e-20 72.3 0.8 8e-20 70.7 0.8 1.7 1 1 0 1 1 1 1 Lysophospholipase catalytic domain fn3 PF00041.21 OPL21397.1 - 0.0087 16.4 0.0 40 4.6 0.0 4.1 3 1 1 4 4 4 3 Fibronectin type III domain AAA_12 PF13087.6 OPL21398.1 - 8.2e-21 74.5 0.4 8.2e-21 74.5 0.4 1.5 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 OPL21398.1 - 5.4e-05 22.9 0.1 0.00014 21.6 0.1 1.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 OPL21398.1 - 0.033 13.9 0.2 0.069 12.9 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase CAML PF14963.6 OPL21398.1 - 0.63 10.1 2.8 0.87 9.7 2.8 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand AAA_12 PF13087.6 OPL21399.1 - 5.7e-21 75.1 0.0 6.1e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.6 OPL21399.1 - 0.022 14.1 0.0 0.024 14.0 0.0 1.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain C2 PF00168.30 OPL21400.1 - 5.2e-16 58.8 0.0 6.4e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 C2 domain Cadherin PF00028.17 OPL21401.1 - 1.7e-13 50.8 1.6 8.9e-06 26.1 0.1 3.0 3 0 0 3 3 3 2 Cadherin domain Big_9 PF17963.1 OPL21401.1 - 0.00087 20.0 2.7 0.00087 20.0 2.7 3.2 3 1 0 3 3 3 2 Bacterial Ig domain OTU PF02338.19 OPL21402.1 - 8.4e-07 29.5 0.0 2.4e-06 28.1 0.0 1.7 1 1 0 1 1 1 1 OTU-like cysteine protease TDH PF03347.13 OPL21403.1 - 0.065 12.8 0.1 0.42 10.1 0.0 2.0 2 0 0 2 2 2 0 Vibrio thermostable direct hemolysin TPP_enzyme_C PF02775.21 OPL21404.1 - 0.039 13.7 0.0 0.039 13.7 0.0 1.0 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Peptidase_C14 PF00656.22 OPL21406.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Caspase domain Cas1_AcylT PF07779.12 OPL21407.1 - 1.6e-60 205.4 8.1 9.2e-52 176.5 4.6 2.3 1 1 1 2 2 2 2 10 TM Acyl Transferase domain found in Cas1p SHR-BD PF06650.12 OPL21408.1 - 2.3e-14 53.5 0.1 2.9e-14 53.1 0.1 1.2 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 SHR-BD PF06650.12 OPL21409.1 - 2e-25 89.7 0.0 2.1e-25 89.6 0.0 1.0 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 Ground-like PF04155.18 OPL21410.1 - 0.012 16.2 0.0 0.013 16.1 0.0 1.1 1 0 0 1 1 1 0 Ground-like domain Peptidase_C14 PF00656.22 OPL21411.1 - 1.5e-19 71.0 0.0 1.8e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Lipocalin_7 PF14651.6 OPL21412.1 - 6e-10 39.2 0.1 6.7e-10 39.0 0.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family HECT PF00632.25 OPL21414.1 - 3.1e-24 86.0 0.0 4.2e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.25 OPL21417.1 - 5.1e-34 117.8 0.7 1.9e-33 116.0 0.7 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL21417.1 - 3e-27 95.5 0.0 5.1e-27 94.8 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 OPL21417.1 - 3.1e-05 23.5 0.0 3.6e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 OPL21417.1 - 0.011 14.5 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 OPL21417.1 - 0.074 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 OPL21417.1 - 0.11 12.4 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family SIL1 PF16782.5 OPL21417.1 - 0.13 11.4 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 Fungal_lectin_2 PF18647.1 OPL21417.1 - 0.14 12.6 0.3 0.14 12.6 0.3 2.3 2 1 1 3 3 3 0 Alpha-galactosyl-binding fungal lectin DUF3808 PF10300.9 OPL21419.1 - 2.5e-08 33.1 0.2 2.8e-08 32.9 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) PLA2_B PF01735.18 OPL21424.1 - 0.029 12.8 0.0 0.037 12.4 0.0 1.2 1 0 0 1 1 1 0 Lysophospholipase catalytic domain LRR_1 PF00560.33 OPL21425.1 - 0.0021 18.3 1.7 3.8 8.4 0.1 4.1 3 1 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.6 OPL21425.1 - 0.1 12.7 10.3 1.3 9.3 0.2 4.4 5 1 1 6 6 6 0 Leucine Rich repeat GAS PF13851.6 OPL21427.1 - 5.3e-82 274.0 33.1 5.3e-82 274.0 33.1 3.1 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 OPL21427.1 - 0.0014 17.6 25.0 0.0014 17.6 25.0 3.8 1 1 2 4 4 4 2 Spc7 kinetochore protein ERM PF00769.19 OPL21427.1 - 0.0053 16.6 24.8 0.0053 16.6 24.8 3.0 2 1 1 3 3 3 1 Ezrin/radixin/moesin family Flg_hook PF02120.16 OPL21427.1 - 0.015 15.2 2.2 2.7 7.9 0.3 3.4 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK DUF3584 PF12128.8 OPL21427.1 - 0.15 9.6 61.3 0.23 8.9 61.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Metal_resist PF13801.6 OPL21427.1 - 0.62 10.3 0.1 0.62 10.3 0.1 4.8 3 3 0 4 4 4 0 Heavy-metal resistance CD225 PF04505.12 OPL21428.1 - 0.00043 20.3 6.1 0.021 14.9 3.0 2.3 1 1 1 2 2 2 2 Interferon-induced transmembrane protein AIG1 PF04548.16 OPL21429.1 - 3.7e-57 193.1 0.4 4.4e-57 192.8 0.4 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 OPL21429.1 - 5.1e-11 42.7 0.2 2.4e-10 40.5 0.1 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 OPL21429.1 - 1.4e-06 28.4 3.8 0.026 14.6 0.1 3.1 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 OPL21429.1 - 1.3e-05 25.1 0.5 0.0011 18.9 0.1 2.4 2 1 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 OPL21429.1 - 0.001 19.2 2.7 0.11 12.6 0.1 2.1 2 0 0 2 2 2 2 Helicase HerA, central domain FeoB_N PF02421.18 OPL21429.1 - 0.0013 18.3 0.1 0.0021 17.6 0.1 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 OPL21429.1 - 0.0038 17.7 2.2 0.022 15.2 0.0 2.1 1 1 1 2 2 2 1 ABC transporter IIGP PF05049.13 OPL21429.1 - 0.0047 16.0 0.1 0.0087 15.1 0.0 1.4 1 1 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Septin PF00735.18 OPL21429.1 - 0.009 15.3 0.1 0.009 15.3 0.1 2.0 2 0 0 2 2 2 1 Septin DUF1837 PF08878.11 OPL21429.1 - 0.011 15.5 1.5 0.015 15.1 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1837) RNA_helicase PF00910.22 OPL21429.1 - 0.011 16.1 0.0 0.027 14.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Gtr1_RagA PF04670.12 OPL21429.1 - 0.047 13.0 0.0 0.077 12.3 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Sigma54_activat PF00158.26 OPL21429.1 - 0.07 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 OPL21429.1 - 0.14 12.5 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2833 PF11090.8 OPL21429.1 - 0.16 12.4 0.1 12 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2833) FtsK_SpoIIIE PF01580.18 OPL21429.1 - 0.39 10.0 1.5 2.2 7.6 0.3 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family FerB PF08150.12 OPL21430.1 - 9.9e-22 77.3 0.1 1.8e-21 76.5 0.1 1.4 1 0 0 1 1 1 1 FerB (NUC096) domain FerA PF08165.11 OPL21430.1 - 4.5e-15 55.4 0.6 1.2e-14 54.0 0.6 1.8 1 0 0 1 1 1 1 FerA (NUC095) domain RE_AlwI PF09491.10 OPL21430.1 - 0.0014 17.5 1.2 0.0021 16.9 1.2 1.2 1 0 0 1 1 1 1 AlwI restriction endonuclease SHE3 PF17078.5 OPL21430.1 - 0.0068 16.1 0.1 0.012 15.4 0.1 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 NACHT_N PF17100.5 OPL21430.1 - 0.0073 16.2 0.1 0.011 15.6 0.1 1.2 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase AAA_15 PF13175.6 OPL21430.1 - 0.055 13.2 0.2 0.073 12.8 0.2 1.1 1 0 0 1 1 1 0 AAA ATPase domain DUF5344 PF17279.2 OPL21430.1 - 0.13 12.8 0.4 1.6 9.3 0.1 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5344) Pkinase PF00069.25 OPL21431.1 - 0.0016 17.9 0.0 0.0024 17.3 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL21431.1 - 0.0038 16.6 0.0 0.0041 16.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RYDR_ITPR PF01365.21 OPL21432.1 - 1.9e-55 187.4 0.3 3e-55 186.8 0.3 1.3 1 0 0 1 1 1 1 RIH domain RyR PF02026.16 OPL21432.1 - 6.3e-39 132.1 0.1 9.1e-27 93.1 0.2 3.1 3 0 0 3 3 3 2 RyR domain Propeptide_C25 PF08126.11 OPL21433.1 - 0.038 13.1 0.1 0.066 12.3 0.1 1.3 1 0 0 1 1 1 0 Propeptide_C25 Toxin_21 PF08091.11 OPL21433.1 - 0.096 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Spider insecticidal peptide Amnionless PF14828.6 OPL21434.1 - 0.00047 19.1 0.7 0.009 14.9 0.0 2.0 2 0 0 2 2 2 1 Amnionless DUF2627 PF11118.8 OPL21434.1 - 0.011 16.3 0.0 0.034 14.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) Orf78 PF06024.12 OPL21434.1 - 0.015 15.6 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF4064 PF13273.6 OPL21434.1 - 0.039 14.2 0.1 0.061 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) SPOR PF05036.13 OPL21434.1 - 0.062 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Sporulation related domain PepSY_TM PF03929.16 OPL21434.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.4 1 1 0 1 1 1 0 PepSY-associated TM region FH2 PF02181.23 OPL21435.1 - 1.3e-07 31.2 0.8 1.8e-07 30.6 0.8 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Mito_fiss_reg PF05308.11 OPL21435.1 - 0.019 15.1 7.5 0.024 14.8 7.5 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator BRX_N PF13713.6 OPL21435.1 - 0.049 13.4 0.1 0.093 12.5 0.1 1.5 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain CAP_N PF01213.19 OPL21435.1 - 4.3 6.7 12.3 5.7 6.3 12.3 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Aminotran_3 PF00202.21 OPL21437.1 - 4.5e-28 98.0 0.0 5.2e-28 97.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III DNA_ligase_IV PF11411.8 OPL21437.1 - 0.0017 18.5 0.3 0.003 17.7 0.3 1.4 1 0 0 1 1 1 1 DNA ligase IV Ank_5 PF13857.6 OPL21438.1 - 1.3e-08 35.0 0.1 2.2e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 OPL21438.1 - 6.5e-06 26.6 0.0 5.6e-05 23.6 0.0 2.4 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 OPL21438.1 - 2.1e-05 24.7 0.9 0.00054 20.3 0.1 2.9 3 1 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 OPL21438.1 - 5e-05 23.8 0.0 6.6e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 OPL21438.1 - 0.0003 21.0 0.0 0.0036 17.7 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeat ATP-gua_PtransN PF02807.15 OPL21440.1 - 1.2e-24 86.4 0.1 2e-24 85.8 0.1 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain ATP-gua_Ptrans PF00217.19 OPL21440.1 - 1.7e-10 40.8 0.0 3.6e-10 39.7 0.0 1.6 2 0 0 2 2 2 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ParG PF09274.10 OPL21440.1 - 0.084 13.0 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 ParG SRI PF08236.11 OPL21441.1 - 2.4e-25 88.5 6.2 3.6e-25 87.9 6.2 1.3 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain WW PF00397.26 OPL21441.1 - 1.1e-10 41.4 4.9 2e-10 40.6 4.9 1.4 1 0 0 1 1 1 1 WW domain Sedlin_N PF04628.13 OPL21441.1 - 0.016 15.3 0.0 0.03 14.4 0.0 1.5 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region Y_phosphatase PF00102.27 OPL21442.1 - 1.4e-31 109.9 5.8 1.9e-31 109.5 5.8 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Imm6 PF14434.6 OPL21442.1 - 0.01 15.8 1.1 0.029 14.3 0.1 2.2 2 1 0 2 2 2 0 Immunity protein Imm6 CHAP PF05257.16 OPL21442.1 - 0.13 12.9 1.1 0.23 12.0 1.1 1.8 1 1 0 1 1 1 0 CHAP domain Sushi PF00084.20 OPL21444.1 - 1.3e-06 28.9 0.2 2.3e-06 28.1 0.2 1.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) p450 PF00067.22 OPL21445.1 - 9.9e-46 156.4 0.9 1.1e-45 156.3 0.9 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF5600 PF18150.1 OPL21445.1 - 0.0031 18.1 0.7 0.008 16.7 0.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) Sec23_trunk PF04811.15 OPL21445.1 - 0.0065 16.1 0.2 0.0065 16.1 0.2 1.6 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain OSCP PF00213.18 OPL21445.1 - 0.011 15.9 0.7 3.1 7.9 0.1 3.1 2 1 0 2 2 2 0 ATP synthase delta (OSCP) subunit 7tm_1 PF00001.21 OPL21448.1 - 3.1e-07 30.0 1.3 4.5e-07 29.5 1.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 OPL21448.1 - 0.0038 16.6 5.4 0.0053 16.1 5.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF2162 PF09930.9 OPL21448.1 - 0.069 12.5 1.8 0.1 12.0 1.8 1.4 1 0 0 1 1 1 0 Predicted transporter (DUF2162) Ig_3 PF13927.6 OPL21449.1 - 1e-11 45.3 0.0 1.5e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL21449.1 - 3.8e-11 42.9 0.0 5.3e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL21449.1 - 4.3e-10 39.8 0.0 6.5e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 OPL21449.1 - 5.8e-05 23.2 0.0 0.0001 22.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 OPL21449.1 - 0.00037 20.6 0.2 0.072 13.3 0.0 2.2 1 1 1 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 OPL21449.1 - 0.0021 18.1 0.0 0.0032 17.5 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 OPL21449.1 - 0.035 14.4 0.0 0.08 13.2 0.0 1.7 1 1 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.8 OPL21449.1 - 0.091 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 EGF_2 PF07974.13 OPL21450.1 - 1.5e-09 38.0 50.0 0.00054 20.3 14.4 3.1 3 0 0 3 3 3 3 EGF-like domain EGF PF00008.27 OPL21450.1 - 1.4e-08 34.9 41.3 0.00034 20.9 10.2 3.5 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 OPL21450.1 - 1.6e-05 25.3 34.0 0.0017 18.9 3.9 4.2 4 1 0 4 4 4 3 Human growth factor-like EGF Laminin_EGF PF00053.24 OPL21450.1 - 0.092 12.9 38.9 1.6 8.9 13.5 3.2 1 1 2 3 3 3 0 Laminin EGF domain EB PF01683.18 OPL21450.1 - 0.65 10.3 35.7 19 5.7 3.9 3.7 1 1 2 3 3 3 0 EB module cEGF PF12662.7 OPL21450.1 - 3.4 7.7 35.0 2.1 8.3 5.7 4.4 3 3 0 3 3 3 0 Complement Clr-like EGF-like Pentapeptide_4 PF13599.6 OPL21453.1 - 0.0024 18.0 0.8 0.16 12.1 0.1 3.0 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) LRR_1 PF00560.33 OPL21453.1 - 0.021 15.3 0.9 27 5.8 0.0 3.8 3 1 0 3 3 3 0 Leucine Rich Repeat Pentapeptide PF00805.22 OPL21453.1 - 0.059 13.0 0.1 1.7 8.4 0.0 2.9 3 0 0 3 3 3 0 Pentapeptide repeats (8 copies) Kazal_3 PF18434.1 OPL21453.1 - 0.088 12.6 7.0 7 6.5 0.1 3.9 1 1 2 3 3 3 0 Kazal-type serine protease inhibitor domain SAM_Ste50p PF09235.10 OPL21453.1 - 0.12 12.6 1.3 1.1 9.6 0.3 2.4 1 1 1 2 2 2 0 Ste50p, sterile alpha motif adh_short PF00106.25 OPL21454.1 - 6.1e-13 48.7 0.0 8.4e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL21454.1 - 5.2e-05 22.9 0.0 7e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 OPL21454.1 - 0.014 15.3 0.0 0.017 15.1 0.0 1.1 1 0 0 1 1 1 0 KR domain DNA_pol_B_exo1 PF03104.19 OPL21455.1 - 1.1e-23 84.0 0.1 1.6e-23 83.4 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain WD40 PF00400.32 OPL21456.1 - 3e-40 135.4 16.8 4e-10 40.1 0.0 6.4 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 OPL21456.1 - 5.3e-18 65.1 0.1 0.014 15.7 0.0 5.7 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 OPL21456.1 - 1.1e-06 27.6 0.1 0.0081 14.9 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 OPL21456.1 - 7.6e-05 22.2 2.8 0.2 10.9 0.1 3.8 2 1 3 5 5 5 4 WD40-like domain Ge1_WD40 PF16529.5 OPL21456.1 - 8.2e-05 21.7 4.1 2.8 6.8 0.0 4.8 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 OPL21456.1 - 0.00031 19.4 0.6 0.44 9.0 0.0 3.1 1 1 3 4 4 4 2 Cytochrome D1 heme domain HPS3_N PF14761.6 OPL21456.1 - 0.00038 20.1 0.0 2.1 7.9 0.0 3.2 3 0 0 3 3 3 2 Hermansky-Pudlak syndrome 3 PALB2_WD40 PF16756.5 OPL21456.1 - 0.0046 15.9 1.5 0.5 9.2 0.3 2.4 3 0 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain BBS2_Mid PF14783.6 OPL21456.1 - 0.013 15.5 0.8 4.6 7.3 0.1 4.0 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region PD40 PF07676.12 OPL21456.1 - 0.071 13.1 1.4 26 4.9 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Frtz PF11768.8 OPL21456.1 - 0.14 10.5 0.0 2.8 6.2 0.0 2.1 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz LRR_6 PF13516.6 OPL21458.1 - 2.2e-07 30.4 1.4 0.0041 17.1 0.3 3.2 3 0 0 3 3 3 2 Leucine Rich repeat Amnionless PF14828.6 OPL21459.1 - 0.0005 19.0 0.0 0.00078 18.4 0.0 1.3 1 0 0 1 1 1 1 Amnionless PhoR PF11808.8 OPL21459.1 - 0.007 16.8 0.2 0.014 15.8 0.0 1.5 2 0 0 2 2 2 1 Phosphate regulon sensor protein PhoR fn3 PF00041.21 OPL21459.1 - 0.038 14.3 0.2 0.12 12.7 0.1 1.8 1 1 1 2 2 2 0 Fibronectin type III domain PMP1_2 PF08114.11 OPL21459.1 - 0.09 12.5 0.8 0.09 12.5 0.8 2.1 2 0 0 2 2 2 0 ATPase proteolipid family CsrA PF02599.16 OPL21459.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Global regulator protein family ShK PF01549.24 OPL21460.1 - 2.7e-06 27.8 27.9 0.00017 22.1 10.5 4.6 4 1 0 4 4 4 2 ShK domain-like VWC PF00093.18 OPL21461.1 - 1.9e-07 31.3 60.1 6.5e-05 23.2 12.8 4.2 4 0 0 4 4 4 3 von Willebrand factor type C domain DUF1496 PF07383.12 OPL21461.1 - 0.069 12.7 4.5 15 5.3 0.4 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1496) Pep_M12B_propep PF01562.19 OPL21462.1 - 2.3e-08 34.3 0.9 6.6e-08 32.9 0.1 2.0 1 1 1 2 2 2 1 Reprolysin family propeptide LRR_8 PF13855.6 OPL21463.1 - 4.5e-14 52.0 17.8 3e-08 33.3 4.9 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 OPL21463.1 - 3.1e-10 40.1 18.1 6.5e-05 23.2 0.9 3.1 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 OPL21463.1 - 0.0028 18.0 12.1 19 6.3 0.0 5.0 5 0 0 5 5 5 2 Leucine Rich Repeat C1q PF00386.21 OPL21464.1 - 1.1e-19 71.0 0.1 1.7e-19 70.3 0.1 1.3 1 0 0 1 1 1 1 C1q domain TIR_2 PF13676.6 OPL21466.1 - 3.5e-07 30.8 0.0 5.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 OPL21466.1 - 2.2e-05 24.4 0.0 3.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 TIR domain NepR PF18557.1 OPL21466.1 - 0.11 12.1 0.8 0.2 11.4 0.1 1.8 2 0 0 2 2 2 0 Anti-sigma factor NepR Lectin_C PF00059.21 OPL21467.1 - 0.0047 17.7 1.0 0.0051 17.5 1.0 1.0 1 0 0 1 1 1 1 Lectin C-type domain UCH PF00443.29 OPL21468.1 - 5.6e-36 124.3 0.8 7.7e-36 123.9 0.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 OPL21468.1 - 2.7e-08 33.8 5.2 0.0018 18.0 0.5 2.3 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RCC1_2 PF13540.6 OPL21469.1 - 8.5e-09 35.0 0.2 4.2e-06 26.4 0.0 2.8 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 OPL21469.1 - 1.5e-06 28.7 3.2 0.00078 20.0 0.0 3.8 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 OPL21470.1 - 3.3e-26 91.6 6.4 1.4e-14 54.5 0.2 3.1 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 OPL21470.1 - 3.5e-19 68.1 5.5 5.2e-10 38.9 1.4 2.2 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat Peptidase_C58 PF03543.14 OPL21470.1 - 0.089 12.5 1.2 7.4 6.2 0.0 2.4 3 0 0 3 3 3 0 Yersinia/Haemophilus virulence surface antigen NHL PF01436.21 OPL21470.1 - 0.093 12.8 0.8 7.8 6.7 0.3 2.7 2 0 0 2 2 2 0 NHL repeat PapC_C PF13953.6 OPL21470.1 - 0.1 12.4 1.1 5.2 7.0 0.2 2.3 2 0 0 2 2 2 0 PapC C-terminal domain Eapp_C PF10238.9 OPL21470.1 - 0.15 12.1 0.0 0.74 9.9 0.0 1.8 2 0 0 2 2 2 0 E2F-associated phosphoprotein OAD_gamma PF04277.13 OPL21470.1 - 0.23 12.1 0.6 0.39 11.3 0.6 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain HEPN_DZIP3 PF18738.1 OPL21471.1 - 1e-34 119.3 0.1 1.3e-34 118.9 0.1 1.2 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN DUF5129 PF17173.4 OPL21472.1 - 0.039 13.1 0.0 0.044 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) PLAT PF01477.23 OPL21473.1 - 8.5e-07 29.6 0.0 1.8e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain GPS PF01825.21 OPL21473.1 - 0.0032 17.9 0.1 0.0074 16.8 0.1 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Mnd1 PF03962.15 OPL21474.1 - 3.5e-26 91.3 1.5 3.5e-26 91.3 1.5 2.0 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 OPL21474.1 - 5.1e-23 80.9 1.3 5.1e-23 80.9 1.3 2.7 3 0 0 3 3 3 1 Leucine zipper with capping helix domain Penicillinase_R PF03965.16 OPL21474.1 - 0.00018 21.8 0.8 0.00037 20.8 0.8 1.5 1 0 0 1 1 1 1 Penicillinase repressor FapA PF03961.13 OPL21474.1 - 0.027 13.1 4.5 0.03 12.9 4.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A ABC_tran_CTD PF16326.5 OPL21474.1 - 0.029 14.6 10.4 0.061 13.6 9.7 2.0 1 1 1 2 2 2 0 ABC transporter C-terminal domain DivIC PF04977.15 OPL21474.1 - 0.17 11.6 3.8 0.84 9.4 1.1 2.4 1 1 1 2 2 2 0 Septum formation initiator YccF PF03733.13 OPL21475.1 - 0.27 12.0 5.2 0.4 11.4 5.2 1.2 1 0 0 1 1 1 0 Inner membrane component domain ESM4 PF15952.5 OPL21476.1 - 0.0012 19.4 1.0 0.0014 19.1 1.0 1.1 1 0 0 1 1 1 1 Enhancer of split M4 family RapH_N PF18801.1 OPL21476.1 - 0.015 15.3 1.8 0.11 12.6 0.1 2.1 1 1 1 2 2 2 0 response regulator aspartate phosphatase H, N terminal RecG_N PF17190.4 OPL21476.1 - 0.032 14.9 4.7 0.076 13.7 1.3 2.0 1 1 1 2 2 2 0 RecG N-terminal helical domain ISG65-75 PF11727.8 OPL21476.1 - 0.065 12.5 3.9 0.082 12.1 3.9 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein RPT PF13446.6 OPL21476.1 - 0.078 12.9 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein DUF29 PF01724.16 OPL21476.1 - 0.085 13.1 2.4 0.11 12.7 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF29 IL2 PF00715.17 OPL21476.1 - 0.13 12.2 0.9 0.17 11.8 0.9 1.4 1 1 0 1 1 1 0 Interleukin 2 NPR1_interact PF15699.5 OPL21476.1 - 0.13 12.9 1.5 0.16 12.6 0.4 1.9 1 1 1 2 2 2 0 NPR1 interacting RsbRD_N PF14361.6 OPL21476.1 - 0.16 12.7 1.9 1.7 9.4 0.3 2.0 1 1 1 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain SIMPL PF04402.14 OPL21476.1 - 0.2 12.1 3.2 0.44 11.0 2.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF541) LMBR1 PF04791.16 OPL21476.1 - 0.24 10.3 3.0 0.29 10.0 3.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3010 PF11215.8 OPL21477.1 - 0.19 12.0 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3010) TPR_12 PF13424.6 OPL21478.1 - 7.2e-31 106.3 4.3 6.3e-17 61.6 0.4 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 OPL21478.1 - 2e-20 72.0 7.2 1.4e-07 31.2 0.0 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 OPL21478.1 - 6.5e-12 44.7 5.6 4e-05 23.5 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 OPL21478.1 - 3.8e-11 42.3 14.4 0.00061 19.5 0.3 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 OPL21478.1 - 2.9e-10 39.4 9.3 0.0057 16.6 0.1 5.7 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 OPL21478.1 - 1.9e-09 36.9 9.2 0.02 15.0 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 OPL21478.1 - 6.5e-09 35.6 3.5 2.4e-08 33.7 3.9 1.7 1 1 1 2 2 2 1 MalT-like TPR region TPR_11 PF13414.6 OPL21478.1 - 7.8e-07 28.7 5.9 0.024 14.3 0.0 3.8 4 0 0 4 4 4 2 TPR repeat TPR_14 PF13428.6 OPL21478.1 - 5.1e-05 23.8 5.7 0.057 14.3 0.0 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 OPL21478.1 - 0.00032 20.9 7.5 0.2 12.1 0.1 4.9 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 OPL21478.1 - 0.003 18.2 8.5 0.052 14.2 0.1 3.8 2 1 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 OPL21478.1 - 0.0038 16.6 2.8 0.046 13.2 0.5 3.4 3 1 0 3 3 3 1 SHNi-TPR SNAP PF14938.6 OPL21478.1 - 0.017 14.6 0.2 0.043 13.2 0.2 1.6 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 OPL21478.1 - 0.07 13.6 10.8 5.1 7.7 1.6 3.7 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 OPL21478.1 - 0.19 12.5 4.3 1.8 9.4 0.9 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 OPL21478.1 - 6.7 7.6 11.2 7.7 7.4 0.1 4.8 6 0 0 6 6 5 0 Tetratricopeptide repeat Fer4_7 PF12838.7 OPL21479.1 - 0.047 14.3 1.9 0.083 13.5 1.9 1.4 1 1 0 1 1 1 0 4Fe-4S dicluster domain Kringle PF00051.18 OPL21480.1 - 1.3e-09 38.3 2.7 1.3e-09 38.3 2.7 2.0 1 1 1 2 2 2 1 Kringle domain MMS22L_C PF14911.6 OPL21481.1 - 1.8e-31 109.6 0.3 6.1e-21 74.9 0.2 2.3 1 1 1 2 2 2 2 S-phase genomic integrity recombination mediator, C-terminal DUF2288 PF10052.9 OPL21481.1 - 0.05 13.7 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2288) Usp PF00582.26 OPL21482.1 - 4.8e-18 66.0 0.1 7.4e-18 65.4 0.1 1.3 1 1 0 1 1 1 1 Universal stress protein family DAGK_cat PF00781.24 OPL21482.1 - 0.075 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF3798 PF12683.7 OPL21482.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3798) WD40 PF00400.32 OPL21483.1 - 3e-10 40.5 0.0 0.28 12.1 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 OPL21483.1 - 0.00099 19.4 0.0 1.5 9.2 0.0 2.7 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 OPL21483.1 - 0.015 14.0 0.0 2.4 6.7 0.1 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 OPL21483.1 - 0.017 14.1 0.1 0.35 9.8 0.1 3.1 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RAB3GAP2_N PF14655.6 OPL21483.1 - 0.029 13.6 0.1 0.057 12.7 0.0 1.5 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus VID27 PF08553.10 OPL21483.1 - 0.071 12.1 0.0 8.1 5.4 0.0 2.5 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain PQQ PF01011.21 OPL21483.1 - 0.13 12.3 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 PQQ enzyme repeat Nckap1 PF09735.9 OPL21484.1 - 2.5e-67 227.8 0.4 2.7e-67 227.7 0.4 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein zf-B_box PF00643.24 OPL21485.1 - 2.5e-14 53.2 26.8 1.6e-09 37.7 7.5 2.8 3 0 0 3 3 3 2 B-box zinc finger zf-C3HC4_3 PF13920.6 OPL21485.1 - 0.011 15.6 6.5 0.011 15.6 6.5 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Sec34 PF04136.15 OPL21485.1 - 0.049 13.5 8.1 0.039 13.8 5.6 1.9 1 1 1 2 2 2 0 Sec34-like family IBR PF01485.21 OPL21485.1 - 1.6 9.0 23.6 2 8.7 4.4 3.2 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 OPL21485.1 - 2.6 8.1 24.7 2.4 8.2 8.1 2.9 1 1 1 2 2 2 0 zinc-RING finger domain Minor_capsid_1 PF10665.9 OPL21486.1 - 0.0033 17.6 0.3 0.0092 16.2 0.3 1.8 1 0 0 1 1 1 1 Minor capsid protein Sulfotransfer_1 PF00685.27 OPL21487.1 - 6e-07 29.2 0.2 7.6e-07 28.9 0.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain GTP_EFTU PF00009.27 OPL21488.1 - 6.3e-05 22.6 0.1 9e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 OPL21488.1 - 0.00037 19.9 0.6 0.00064 19.2 0.6 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 OPL21488.1 - 0.00085 18.8 0.8 0.0018 17.7 0.8 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family cobW PF02492.19 OPL21488.1 - 0.027 14.1 0.2 0.046 13.3 0.2 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 OPL21488.1 - 0.034 14.2 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase NOG1 PF06858.14 OPL21488.1 - 0.039 13.7 0.4 0.098 12.4 0.4 1.7 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) ATP_bind_1 PF03029.17 OPL21488.1 - 0.045 13.5 0.4 0.061 13.1 0.4 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein NAD_binding_1 PF00175.21 OPL21489.1 - 3.2e-17 63.2 0.0 5.2e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PhoU PF01895.19 OPL21489.1 - 0.0088 16.5 0.3 0.02 15.3 0.3 1.5 1 0 0 1 1 1 1 PhoU domain Phage_TAC_12 PF12363.8 OPL21489.1 - 0.076 13.4 0.2 0.15 12.4 0.2 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC Ank_2 PF12796.7 OPL21490.1 - 1.3e-28 99.4 1.2 4.1e-18 65.8 0.4 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL21490.1 - 1.1e-25 89.6 2.9 8.2e-11 42.2 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL21490.1 - 4.4e-24 81.9 0.1 8.2e-05 22.7 0.2 5.3 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 OPL21490.1 - 3.9e-23 81.2 0.7 2.7e-08 33.9 0.0 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 OPL21490.1 - 2.3e-19 68.9 0.5 0.00056 20.2 0.4 5.2 5 0 0 5 5 5 4 Ankyrin repeat DUF4477 PF14780.6 OPL21491.1 - 1e-25 90.5 3.2 1.6e-25 89.9 3.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) fn3 PF00041.21 OPL21492.1 - 0.011 16.0 0.8 0.025 14.9 0.8 1.6 1 1 0 1 1 1 0 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 OPL21492.1 - 0.012 16.2 0.2 0.021 15.4 0.2 1.4 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Podoplanin PF05808.11 OPL21492.1 - 0.032 14.3 0.1 0.049 13.7 0.1 1.3 1 0 0 1 1 1 0 Podoplanin fn3_4 PF16794.5 OPL21492.1 - 0.039 13.9 0.0 0.19 11.6 0.0 2.0 1 1 0 1 1 1 0 Fibronectin-III type domain HTH_24 PF13412.6 OPL21492.1 - 0.17 11.5 0.3 3.8 7.1 0.1 2.4 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Lipocalin PF00061.23 OPL21494.1 - 4.5e-09 36.6 0.8 5.6e-09 36.4 0.8 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 OPL21494.1 - 0.068 13.1 0.0 0.1 12.5 0.0 1.3 1 1 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family FAM176 PF14851.6 OPL21495.1 - 0.0029 17.3 0.0 0.004 16.8 0.0 1.2 1 0 0 1 1 1 1 FAM176 family CopC PF04234.12 OPL21495.1 - 0.0075 17.3 0.2 0.011 16.8 0.2 1.3 1 0 0 1 1 1 1 CopC domain G6B PF15096.6 OPL21495.1 - 0.0076 16.1 0.0 0.0096 15.7 0.0 1.1 1 0 0 1 1 1 1 G6B family EphA2_TM PF14575.6 OPL21495.1 - 0.021 15.7 0.0 0.033 15.1 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Myc_target_1 PF15179.6 OPL21495.1 - 0.029 14.3 0.8 0.063 13.2 0.5 1.5 1 1 1 2 2 2 0 Myc target protein 1 TRSP PF12500.8 OPL21495.1 - 0.033 14.1 0.0 0.042 13.7 0.0 1.2 1 0 0 1 1 1 0 TRSP domain C terminus to PRTase_2 Shisa PF13908.6 OPL21495.1 - 0.072 13.3 0.0 0.094 12.9 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator MFS_1 PF07690.16 OPL21496.1 - 3.4e-21 75.6 5.1 3.8e-15 55.7 0.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4118 PF13493.6 OPL21496.1 - 0.29 10.9 5.6 0.056 13.2 1.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) IncF PF17626.2 OPL21496.1 - 4.2 7.8 6.1 2.4 8.6 0.9 2.6 3 0 0 3 3 3 0 Inclusion membrane protein F Glyco_transf_22 PF03901.17 OPL21497.1 - 5.7e-33 114.8 8.9 6.6e-33 114.5 8.9 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.6 OPL21497.1 - 0.024 14.9 6.3 0.032 14.4 6.3 1.2 1 0 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF4789 PF16033.5 OPL21500.1 - 0.17 12.4 3.4 1.3 9.6 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4789) Neur_chan_LBD PF02931.23 OPL21501.1 - 3.6e-30 105.0 0.9 1.2e-22 80.5 0.0 3.0 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 OPL21501.1 - 1.3e-15 58.1 2.7 2.1e-15 57.4 2.7 1.4 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PBP1_TM PF14812.6 OPL21501.1 - 0.88 10.0 3.9 1.9 8.9 3.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 OPL21501.1 - 1.1 9.0 4.5 0.39 10.4 1.3 1.9 2 0 0 2 2 2 0 FAM176 family Lectin_C PF00059.21 OPL21502.1 - 0.0022 18.7 0.4 0.0022 18.7 0.4 1.3 1 1 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 OPL21503.1 - 1.8e-10 41.5 0.1 2e-10 41.3 0.1 1.0 1 0 0 1 1 1 1 Lectin C-type domain V-set PF07686.17 OPL21504.1 - 0.029 14.5 0.2 0.064 13.4 0.2 1.5 1 1 0 1 1 1 0 Immunoglobulin V-set domain HEPN_DZIP3 PF18738.1 OPL21505.1 - 7.7e-20 71.1 0.0 1e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN HEPN_RiboL-PSP PF18735.1 OPL21505.1 - 3.6e-05 23.8 0.1 5.6e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 RiboL-PSP-HEPN DUF4145 PF13643.6 OPL21505.1 - 0.15 12.2 0.2 0.56 10.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) MRP-S32 PF10210.9 OPL21506.1 - 4.7e-24 84.8 0.2 6.9e-24 84.2 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 HMG_box PF00505.19 OPL21507.1 - 1.7e-05 25.1 0.1 3.6e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 OPL21507.1 - 0.045 14.4 0.2 0.13 12.8 0.1 1.9 1 1 0 1 1 1 0 HMG-box domain PSI PF01437.25 OPL21508.1 - 0.017 15.7 0.6 0.026 15.0 0.6 1.3 1 0 0 1 1 1 0 Plexin repeat zf-LITAF-like PF10601.9 OPL21509.1 - 3.5e-24 84.9 10.5 6.6e-24 84.0 10.5 1.5 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Glyc_hyd_38C_2 PF18230.1 OPL21509.1 - 0.0059 16.7 0.2 0.0099 16.0 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal sub-domain Lipocalin PF00061.23 OPL21509.1 - 0.1 12.8 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Zn_Tnp_IS1595 PF12760.7 OPL21509.1 - 0.24 11.4 5.4 2.1 8.4 0.2 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain PHM7_cyt PF14703.6 OPL21510.1 - 7.8e-17 62.1 0.0 1.1e-16 61.6 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_7TM PF02714.15 OPL21510.1 - 3.3e-08 33.2 5.9 5.7e-08 32.4 5.9 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate Phtf-FEM1B_bdg PF12129.8 OPL21510.1 - 0.55 10.1 4.7 0.99 9.2 4.7 1.4 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor VWD PF00094.25 OPL21512.1 - 0.0018 18.6 0.0 0.0034 17.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain AGH PF17558.2 OPL21512.1 - 0.26 11.4 3.4 0.16 12.1 0.5 2.0 2 1 1 3 3 3 0 Androgenic gland hormone COR PF16095.5 OPL21513.1 - 6.6e-22 78.3 0.7 6.6e-22 78.3 0.7 1.6 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain HEPN_DZIP3 PF18738.1 OPL21513.1 - 9.2e-06 25.5 0.0 2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN Lig_C PF18330.1 OPL21513.1 - 0.098 12.7 0.5 2.1 8.4 0.0 2.7 2 0 0 2 2 2 0 Ligase Pab1020 C-terminal region Ion_trans_2 PF07885.16 OPL21514.1 - 1.6e-11 44.0 1.2 1.6e-11 44.0 1.2 1.8 2 0 0 2 2 2 1 Ion channel Integrin_alpha PF00357.20 OPL21514.1 - 0.0011 18.8 1.8 0.0026 17.6 1.8 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region MBOAT PF03062.19 OPL21516.1 - 1.8e-39 136.1 28.7 2.7e-39 135.5 28.5 1.4 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Presenilin PF01080.17 OPL21517.1 - 0.032 13.0 2.8 0.031 13.0 2.8 1.1 1 0 0 1 1 1 0 Presenilin eIF-4B PF06273.11 OPL21517.1 - 0.1 11.6 9.1 0.12 11.4 9.1 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B CEND1 PF15677.5 OPL21517.1 - 0.16 12.5 10.5 0.19 12.2 10.5 1.1 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 Zip PF02535.22 OPL21517.1 - 0.27 10.4 3.3 0.29 10.3 3.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 OPL21517.1 - 0.72 9.8 6.2 0.83 9.6 6.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RAP1 PF07218.11 OPL21517.1 - 0.87 7.8 6.8 1 7.6 6.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Hamartin PF04388.12 OPL21517.1 - 1.3 7.6 9.1 1.4 7.5 9.1 1.0 1 0 0 1 1 1 0 Hamartin protein Dicty_REP PF05086.12 OPL21517.1 - 1.6 6.7 8.3 1.8 6.5 8.3 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Menin PF05053.13 OPL21517.1 - 4.1 5.6 6.0 4.5 5.5 6.0 1.0 1 0 0 1 1 1 0 Menin GREB1 PF15782.5 OPL21517.1 - 6.9 3.7 8.5 7.4 3.5 8.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DDHD PF02862.17 OPL21519.1 - 9.2e-18 65.2 5.7 1.5e-17 64.5 0.1 2.5 2 1 1 3 3 3 1 DDHD domain Neur_chan_LBD PF02931.23 OPL21520.1 - 4.4e-23 81.9 0.3 1.3e-22 80.3 0.3 1.8 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain CARD_2 PF16739.5 OPL21522.1 - 1.1e-06 28.5 4.4 1.4e-05 25.0 0.2 3.4 3 1 1 4 4 4 1 Caspase recruitment domain CARD PF00619.21 OPL21522.1 - 5e-06 26.5 5.7 5.4e-06 26.3 0.2 3.5 3 1 1 4 4 4 1 Caspase recruitment domain FKBP_N_2 PF18023.1 OPL21522.1 - 0.023 14.8 0.2 0.12 12.4 0.1 2.2 2 0 0 2 2 2 0 BDBT FKBP like N-terminal DUF4490 PF14892.6 OPL21523.1 - 9.7e-40 134.8 0.6 1e-39 134.7 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4490) FHA PF00498.26 OPL21524.1 - 1.2e-11 44.8 0.1 1.6e-11 44.3 0.1 1.2 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 OPL21524.1 - 0.00071 19.8 0.0 0.001 19.4 0.0 1.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF459 PF04311.13 OPL21524.1 - 0.0019 17.3 0.0 0.0021 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF459) 7tm_2 PF00002.24 OPL21525.1 - 4.1e-16 59.0 10.1 2.1e-11 43.6 5.5 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) Baculo_11_kDa PF06143.11 OPL21525.1 - 0.023 14.3 3.9 0.037 13.6 3.0 1.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF1201 PF06716.11 OPL21525.1 - 0.29 11.2 5.1 5.8 7.0 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) F5_F8_type_C PF00754.25 OPL21526.1 - 0.00012 22.2 0.0 0.00015 21.9 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain BRE PF06113.12 OPL21528.1 - 4.2e-86 288.7 1.6 5.1e-86 288.4 1.6 1.0 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) SH3_9 PF14604.6 OPL21531.1 - 0.069 13.0 0.2 0.28 11.1 0.0 2.0 2 0 0 2 2 2 0 Variant SH3 domain ResIII PF04851.15 OPL21532.1 - 8e-19 68.3 0.3 1.5e-18 67.4 0.3 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 OPL21532.1 - 3.6e-15 56.2 0.0 5.8e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase I-set PF07679.16 OPL21532.1 - 2.2e-09 37.2 0.0 5.4e-09 36.0 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL21532.1 - 1.1e-08 35.6 0.0 2.6e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain AAA_19 PF13245.6 OPL21532.1 - 0.0035 17.7 0.6 0.19 12.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain Ig_2 PF13895.6 OPL21532.1 - 0.013 15.9 0.0 0.043 14.1 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain Zot PF05707.12 OPL21532.1 - 0.013 15.2 0.1 0.069 12.8 0.0 2.2 1 1 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_22 PF13401.6 OPL21532.1 - 0.04 14.2 0.2 0.37 11.1 0.1 2.4 1 1 0 1 1 1 0 AAA domain ig PF00047.25 OPL21532.1 - 0.088 13.0 0.2 0.4 10.9 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 OPL21532.1 - 0.16 12.2 0.0 0.86 9.8 0.0 2.2 1 1 1 2 2 2 0 Immunoglobulin V-set domain FRG1 PF06229.12 OPL21533.1 - 1.5e-61 207.5 0.0 2e-61 207.1 0.0 1.1 1 0 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 OPL21533.1 - 3.1e-08 33.8 0.0 2.2e-07 31.1 0.0 2.0 1 1 1 2 2 2 1 Fascin domain Ig_3 PF13927.6 OPL21535.1 - 1.3e-19 70.5 0.4 1.8e-14 54.1 0.2 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL21535.1 - 5.6e-19 68.0 0.1 2e-12 47.0 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL21535.1 - 2.3e-11 43.8 0.0 1.2e-08 35.2 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL21535.1 - 1.8e-10 40.9 0.0 5.7e-05 23.2 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 OPL21535.1 - 6.5e-08 32.7 0.1 0.0039 17.3 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL21535.1 - 0.036 13.6 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain YaiA PF16362.5 OPL21535.1 - 0.078 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 YaiA protein EF-hand_7 PF13499.6 OPL21536.1 - 5.5e-25 87.6 1.2 1.6e-15 57.3 0.6 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 OPL21536.1 - 1.3e-24 83.8 0.9 5.3e-08 31.9 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 OPL21536.1 - 5.9e-23 80.5 2.8 7.9e-11 41.6 0.0 4.3 3 2 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 OPL21536.1 - 1.4e-17 62.1 0.9 5.2e-08 32.2 0.0 4.4 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 OPL21536.1 - 6.6e-12 44.4 0.1 0.0001 21.6 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 OPL21536.1 - 1.1e-07 32.1 0.0 0.0037 17.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 OPL21536.1 - 0.00046 20.1 0.1 0.006 16.5 0.0 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.10 OPL21536.1 - 0.00052 20.1 0.0 0.0012 18.9 0.0 1.8 1 1 0 1 1 1 1 Ca2+ insensitive EF hand SPARC_Ca_bdg PF10591.9 OPL21536.1 - 0.0036 17.6 0.0 0.0067 16.7 0.0 1.7 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_3 PF13624.6 OPL21536.1 - 0.0054 16.5 0.4 2.8 7.7 0.1 2.1 1 1 1 2 2 2 2 SurA N-terminal domain EF-hand_11 PF08976.11 OPL21536.1 - 0.012 16.5 0.2 0.091 13.6 0.0 2.2 2 1 1 3 3 2 0 EF-hand domain DUF3349 PF11829.8 OPL21536.1 - 0.015 16.0 0.3 1.3 9.8 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) UPF0154 PF03672.13 OPL21536.1 - 0.1 12.7 0.0 8.7 6.5 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) Pex24p PF06398.11 OPL21538.1 - 0.47 9.4 4.9 0.61 9.0 4.9 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Ion_trans PF00520.31 OPL21539.1 - 4.7e-05 22.7 8.4 6.9e-05 22.2 8.4 1.2 1 1 0 1 1 1 1 Ion transport protein Hormone_recep PF00104.30 OPL21541.1 - 2.2e-16 60.1 3.1 3.7e-16 59.3 3.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 OPL21541.1 - 0.014 15.8 2.3 0.014 15.8 2.3 2.0 2 0 0 2 2 2 0 Zinc finger, C4 type (two domains) Fibrinogen_C PF00147.18 OPL21542.1 - 3.2e-44 151.4 8.7 3.8e-44 151.1 8.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ATG16 PF08614.11 OPL21543.1 - 2.4e-07 31.2 59.2 0.00019 21.7 19.8 4.4 1 1 3 4 4 4 2 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 OPL21543.1 - 7.8e-07 29.0 51.5 0.026 14.5 5.0 6.4 2 1 5 7 7 7 4 TATA element modulatory factor 1 DNA binding ADIP PF11559.8 OPL21543.1 - 1.3e-06 28.6 65.5 0.004 17.2 21.2 4.5 1 1 3 4 4 4 2 Afadin- and alpha -actinin-Binding KASH_CCD PF14662.6 OPL21543.1 - 1.7e-06 28.0 55.6 0.0029 17.5 13.5 4.4 1 1 2 4 4 4 3 Coiled-coil region of CCDC155 or KASH CENP-F_leu_zip PF10473.9 OPL21543.1 - 1.1e-05 25.4 52.1 0.0011 19.0 7.5 4.7 1 1 4 5 5 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 OPL21543.1 - 0.00013 22.3 52.0 0.00072 20.0 1.0 6.6 2 1 2 4 4 3 3 Cell division protein ZapB LPP PF04728.13 OPL21543.1 - 0.00022 21.6 31.7 0.0017 18.7 1.7 7.3 4 3 2 6 6 6 2 Lipoprotein leucine-zipper Spc7 PF08317.11 OPL21543.1 - 0.00022 20.2 55.4 0.0012 17.8 17.1 3.9 1 1 4 5 5 5 4 Spc7 kinetochore protein DUF724 PF05266.14 OPL21543.1 - 0.00042 20.2 4.4 0.00042 20.2 4.4 4.0 1 1 2 3 3 2 2 Protein of unknown function (DUF724) Fez1 PF06818.15 OPL21543.1 - 0.0005 20.6 47.9 0.003 18.0 9.6 3.4 1 1 2 3 3 3 2 Fez1 APC_N_CC PF16689.5 OPL21543.1 - 0.00066 19.7 1.3 0.00066 19.7 1.3 4.4 3 2 1 4 4 4 1 Coiled-coil N-terminus of APC, dimerisation domain AAA_13 PF13166.6 OPL21543.1 - 0.00097 17.9 21.1 0.00097 17.9 21.1 2.2 1 1 1 2 2 2 1 AAA domain FPP PF05911.11 OPL21543.1 - 0.0013 17.1 27.2 0.0013 17.1 27.2 2.1 1 1 1 2 2 2 1 Filament-like plant protein, long coiled-coil DivIC PF04977.15 OPL21543.1 - 0.0026 17.5 57.3 0.055 13.2 0.7 7.8 3 1 4 8 8 8 3 Septum formation initiator bZIP_1 PF00170.21 OPL21543.1 - 0.0034 17.5 11.2 0.016 15.3 2.0 7.5 4 2 5 9 9 8 2 bZIP transcription factor ERM PF00769.19 OPL21543.1 - 0.0049 16.7 33.8 0.66 9.7 2.9 3.2 1 1 2 3 3 3 2 Ezrin/radixin/moesin family PspA_IM30 PF04012.12 OPL21543.1 - 0.0052 16.4 7.8 0.0052 16.4 7.8 4.9 2 1 2 5 5 5 2 PspA/IM30 family TACC_C PF05010.14 OPL21543.1 - 0.0055 16.5 11.4 0.0055 16.5 11.4 3.7 1 1 2 3 3 3 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal GAS PF13851.6 OPL21543.1 - 0.0062 15.9 50.8 0.031 13.6 10.0 4.8 1 1 3 4 4 4 3 Growth-arrest specific micro-tubule binding Pox_A_type_inc PF04508.12 OPL21543.1 - 0.0075 16.1 0.0 18 5.4 0.0 3.9 1 1 3 4 4 4 0 Viral A-type inclusion protein repeat Cnn_1N PF07989.11 OPL21543.1 - 0.011 15.8 4.8 0.011 15.8 4.8 6.8 2 2 4 6 6 4 0 Centrosomin N-terminal motif 1 HMMR_C PF15908.5 OPL21543.1 - 0.013 15.7 0.9 0.013 15.7 0.9 4.7 1 1 3 5 5 4 0 Hyaluronan mediated motility receptor C-terminal BRE1 PF08647.11 OPL21543.1 - 0.021 14.9 5.9 0.021 14.9 5.9 5.3 1 1 4 5 5 5 0 BRE1 E3 ubiquitin ligase CENP-H PF05837.12 OPL21543.1 - 0.032 14.6 48.2 0.45 11.0 11.3 4.8 1 1 3 4 4 4 0 Centromere protein H (CENP-H) TMF_TATA_bd PF12325.8 OPL21543.1 - 0.036 14.3 46.4 0.88 9.8 9.2 5.2 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding TSC22 PF01166.18 OPL21543.1 - 0.052 13.9 46.2 0.29 11.5 0.2 9.3 5 2 3 9 9 9 0 TSC-22/dip/bun family Shugoshin_N PF07558.11 OPL21543.1 - 0.063 13.2 0.1 0.063 13.2 0.1 6.8 4 2 3 7 7 5 0 Shugoshin N-terminal coiled-coil region GIT_CC PF16559.5 OPL21543.1 - 0.08 12.8 0.1 0.08 12.8 0.1 8.0 3 3 7 10 10 10 0 GIT coiled-coil Rho guanine nucleotide exchange factor Filament PF00038.21 OPL21543.1 - 0.088 12.4 47.9 2.2 7.8 4.7 4.8 1 1 5 6 6 5 0 Intermediate filament protein APG6_N PF17675.1 OPL21543.1 - 0.2 12.2 50.1 0.038 14.5 16.7 4.4 1 1 3 4 4 4 0 Apg6 coiled-coil region FAM76 PF16046.5 OPL21543.1 - 0.26 10.6 49.4 0.34 10.2 14.4 3.6 1 1 2 3 3 2 0 FAM76 protein YabA PF06156.13 OPL21543.1 - 0.3 11.7 43.6 0.059 14.0 5.5 5.5 1 1 4 5 5 5 0 Initiation control protein YabA Atg14 PF10186.9 OPL21543.1 - 0.4 9.7 49.3 0.21 10.6 10.4 3.3 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4618 PF15397.6 OPL21543.1 - 0.41 10.0 46.4 0.068 12.6 3.0 4.3 1 1 2 3 3 2 0 Domain of unknown function (DUF4618) FlaC_arch PF05377.11 OPL21543.1 - 0.6 10.5 32.3 0.19 12.2 2.7 7.0 3 2 5 8 8 8 0 Flagella accessory protein C (FlaC) Tropomyosin_1 PF12718.7 OPL21543.1 - 0.84 9.8 55.9 0.27 11.4 20.7 4.7 1 1 3 4 4 4 0 Tropomyosin like HAP1_N PF04849.13 OPL21543.1 - 1 8.5 56.1 0.097 11.9 21.3 2.2 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Yuri_gagarin PF15934.5 OPL21543.1 - 1.1 9.1 45.6 1.1 9.0 2.4 3.6 1 1 2 3 3 3 0 Yuri gagarin HALZ PF02183.18 OPL21543.1 - 1.1 9.5 32.3 2.1 8.6 0.4 7.4 6 2 2 8 8 8 0 Homeobox associated leucine zipper MAD PF05557.13 OPL21543.1 - 1.3 7.3 52.2 2.7 6.2 5.6 3.1 1 1 2 3 3 3 0 Mitotic checkpoint protein UPF0242 PF06785.11 OPL21543.1 - 1.6 8.8 60.5 1.4 9.0 13.0 4.6 1 1 2 3 3 2 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 OPL21543.1 - 1.9 9.2 48.7 1.2 9.8 0.3 6.8 1 1 4 6 6 6 0 SlyX Cast PF10174.9 OPL21543.1 - 2.1 6.4 57.4 0.35 9.1 27.9 2.5 1 1 2 3 3 3 0 RIM-binding protein of the cytomatrix active zone Lebercilin PF15619.6 OPL21543.1 - 2.2 7.9 56.1 1.2 8.8 7.9 4.4 1 1 3 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease CALCOCO1 PF07888.11 OPL21543.1 - 2.5 6.9 49.9 0.15 10.9 31.5 2.7 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.12 OPL21543.1 - 2.6 8.1 51.5 0.064 13.3 4.4 4.6 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 OPL21543.1 - 2.9 7.9 39.1 0.38 10.8 6.2 5.0 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Rop-like PF05082.13 OPL21543.1 - 3.1 7.7 8.0 9.1 6.2 0.3 4.3 3 1 1 4 4 3 0 Rop-like HAUS5 PF14817.6 OPL21543.1 - 3.3 6.4 36.8 0.28 9.9 8.7 3.2 1 1 1 3 3 3 0 HAUS augmin-like complex subunit 5 Rootletin PF15035.6 OPL21543.1 - 3.8 7.5 53.4 3.5 7.6 8.6 4.2 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion DUF812 PF05667.11 OPL21543.1 - 4.5 6.0 46.9 84 1.8 41.0 3.1 1 1 1 2 2 1 0 Protein of unknown function (DUF812) Jnk-SapK_ap_N PF09744.9 OPL21543.1 - 4.8 7.4 52.7 1.9 8.7 17.7 4.3 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 DUF4795 PF16043.5 OPL21543.1 - 7.1 6.2 51.7 3.5 7.2 10.8 4.6 1 1 1 3 3 2 0 Domain of unknown function (DUF4795) YtxH PF12732.7 OPL21543.1 - 7.6 7.1 13.0 9.2e+03 -2.7 13.0 4.1 1 1 0 1 1 0 0 YtxH-like protein DUF3450 PF11932.8 OPL21543.1 - 8.2 5.6 51.7 2.3 7.4 9.8 4.6 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) JIP_LZII PF16471.5 OPL21543.1 - 9.3 6.5 36.6 0.58 10.4 4.8 5.4 2 1 3 5 5 5 0 JNK-interacting protein leucine zipper II Phage_GP20 PF06810.11 OPL21543.1 - 10 5.9 56.5 0.66 9.8 12.1 5.1 1 1 4 5 5 5 0 Phage minor structural protein GP20 A_deamin PF02137.18 OPL21544.1 - 4.8e-80 269.5 0.4 7.9e-79 265.5 0.4 2.0 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain BDHCT PF08072.11 OPL21544.1 - 0.1 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 BDHCT (NUC031) domain MFS_1 PF07690.16 OPL21545.1 - 2.3e-32 112.3 50.3 2e-19 69.7 6.0 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_4 PF06779.14 OPL21545.1 - 3.5e-06 26.6 21.2 1e-05 25.0 9.6 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Fasciclin PF02469.22 OPL21546.1 - 3.9e-26 91.8 6.0 4.4e-13 49.6 0.1 3.0 2 1 1 3 3 3 3 Fasciclin domain Lectin_C PF00059.21 OPL21548.1 - 3.4e-09 37.4 0.9 1.4e-08 35.5 0.0 2.0 2 0 0 2 2 2 1 Lectin C-type domain AIG1 PF04548.16 OPL21549.1 - 0.003 16.9 0.5 0.0035 16.7 0.5 1.1 1 0 0 1 1 1 1 AIG1 family tRNA-synt_1c PF00749.21 OPL21550.1 - 0.091 11.6 2.6 0.11 11.4 2.6 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain TraC PF07820.12 OPL21550.1 - 0.27 11.6 4.0 0.33 11.3 3.4 1.5 1 1 0 1 1 1 0 TraC-like protein zf-B_box PF00643.24 OPL21551.1 - 9.8e-11 41.6 25.3 1.4e-07 31.5 12.2 4.3 4 1 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 OPL21551.1 - 1.7e-06 27.9 5.5 1.7e-06 27.9 5.5 4.7 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 OPL21551.1 - 7e-06 26.1 6.8 7e-06 26.1 6.8 4.4 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 OPL21551.1 - 0.0001 22.1 5.8 0.0001 22.1 5.8 4.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) CEBP_ZZ PF16366.5 OPL21551.1 - 0.0051 17.0 3.3 0.0051 17.0 3.3 3.6 3 0 0 3 3 3 1 Cytoplasmic polyadenylation element-binding protein ZZ domain DUF4335 PF14233.6 OPL21551.1 - 0.086 12.7 0.4 0.21 11.5 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) NHL PF01436.21 OPL21551.1 - 0.14 12.3 0.0 0.39 10.8 0.0 1.8 1 0 0 1 1 1 0 NHL repeat 3HCDH_N PF02737.18 OPL21552.1 - 2.3e-44 151.4 0.0 2.9e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 OPL21552.1 - 3.4e-05 23.3 0.0 8.4e-05 22.0 0.0 1.6 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 OPL21552.1 - 0.00011 22.2 0.0 0.00024 21.1 0.0 1.6 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 OPL21552.1 - 0.00014 21.5 0.0 0.0002 21.0 0.0 1.4 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 OPL21552.1 - 0.00091 18.6 0.0 0.00097 18.5 0.0 1.2 1 1 0 1 1 1 1 FAD binding domain NAD_binding_2 PF03446.15 OPL21552.1 - 0.0028 17.8 0.0 0.0059 16.8 0.0 1.4 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox PF00070.27 OPL21552.1 - 0.004 17.7 0.0 0.0068 16.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 OPL21552.1 - 0.0067 15.7 0.0 0.0083 15.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 OPL21552.1 - 0.017 15.3 0.0 0.039 14.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 OPL21552.1 - 0.035 13.8 0.0 0.052 13.2 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 OPL21552.1 - 0.061 13.9 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short_C2 PF13561.6 OPL21552.1 - 0.087 12.4 0.0 0.19 11.2 0.0 1.5 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 OPL21552.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase LRR_adjacent PF08191.11 OPL21553.1 - 0.026 14.7 0.1 3.1 8.1 0.0 2.7 2 0 0 2 2 2 0 LRR adjacent DUF1374 PF07118.11 OPL21553.1 - 0.4 11.2 1.9 5.4 7.6 0.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1374) MFS_1 PF07690.16 OPL21554.1 - 1.3e-08 34.2 1.0 2e-07 30.2 1.4 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TMEM154 PF15102.6 OPL21555.1 - 2.5e-06 27.4 6.5 2.5e-06 27.4 6.5 1.4 1 1 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.6 OPL21555.1 - 0.00013 21.8 0.3 0.00014 21.7 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF3377 PF11857.8 OPL21555.1 - 0.00084 19.2 0.7 0.0022 17.9 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3377) COX2_TM PF02790.15 OPL21555.1 - 0.00089 19.4 2.4 0.0036 17.4 0.1 2.4 1 1 2 3 3 3 1 Cytochrome C oxidase subunit II, transmembrane domain DUF5305 PF17231.2 OPL21555.1 - 0.003 17.0 5.3 0.003 17.0 5.3 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5305) Protocadherin PF08374.11 OPL21555.1 - 0.011 15.8 1.1 0.011 15.8 1.1 2.0 1 1 1 2 2 2 0 Protocadherin Mucin PF01456.17 OPL21555.1 - 0.027 14.5 7.9 0.039 14.0 7.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF1120 PF06551.12 OPL21555.1 - 0.029 14.5 0.9 0.047 13.9 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1120) RIFIN PF02009.16 OPL21555.1 - 0.033 14.1 5.2 0.04 13.8 5.2 1.1 1 0 0 1 1 1 0 Rifin Trp_oprn_chp PF09534.10 OPL21555.1 - 0.038 13.8 0.0 0.048 13.4 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TNFR_16_TM PF18422.1 OPL21555.1 - 0.038 13.9 0.3 0.074 13.0 0.3 1.4 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain PRIMA1 PF16101.5 OPL21555.1 - 0.059 13.4 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Insulin_TMD PF17870.1 OPL21555.1 - 0.086 12.9 2.8 0.18 11.9 2.8 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment AMA-1 PF02430.15 OPL21555.1 - 0.092 11.7 0.2 0.094 11.7 0.2 1.1 1 0 0 1 1 1 0 Apical membrane antigen 1 DUF4519 PF15012.6 OPL21555.1 - 0.13 12.4 2.5 0.16 12.1 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Orf78 PF06024.12 OPL21555.1 - 0.14 12.4 1.5 0.18 12.1 0.6 1.7 1 1 1 2 2 2 0 Orf78 (ac78) FancD2 PF14631.6 OPL21558.1 - 5.4e-102 342.3 1.0 9.1e-85 285.2 0.3 2.0 1 1 1 2 2 2 2 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.6 OPL21558.1 - 2e-05 25.0 0.0 5.1e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 FANCI solenoid 2 Bromo_TP_like PF17027.5 OPL21558.1 - 0.021 15.0 0.2 0.097 12.8 0.0 2.3 3 1 0 3 3 3 0 Histone-fold protein betaPIX_CC PF16523.5 OPL21560.1 - 7.8e-17 60.9 0.4 9.3e-17 60.6 0.4 1.0 1 0 0 1 1 1 1 betaPIX coiled coil AdoHcyase PF05221.17 OPL21560.1 - 0.033 13.3 0.0 0.033 13.3 0.0 1.0 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase Serine_protease PF18405.1 OPL21561.1 - 0.0004 19.6 3.1 0.038 13.2 0.1 2.6 1 1 1 2 2 2 2 Gammaproteobacterial serine protease Fructosamin_kin PF03881.14 OPL21562.1 - 2e-22 79.8 0.2 1.1e-21 77.3 0.2 1.8 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.23 OPL21562.1 - 0.0028 17.6 0.0 0.004 17.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family K1377 PF15352.6 OPL21564.1 - 3.7e-07 28.9 1.2 3.7e-07 28.9 1.2 5.8 3 2 1 4 4 4 2 Susceptibility to monomelic amyotrophy C1q PF00386.21 OPL21565.1 - 1.3e-15 57.7 3.7 1.9e-15 57.2 3.7 1.3 1 0 0 1 1 1 1 C1q domain Sugarporin_N PF11471.8 OPL21565.1 - 0.006 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension GP41 PF00517.17 OPL21565.1 - 0.0096 15.8 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Retroviral envelope protein Arch_flagellin PF01917.16 OPL21565.1 - 0.088 13.0 0.6 0.1 12.8 0.6 1.2 1 0 0 1 1 1 0 Archaebacterial flagellin HSP70 PF00012.20 OPL21566.1 - 8.2e-11 40.8 0.2 7.4e-09 34.3 0.2 2.1 1 1 0 1 1 1 1 Hsp70 protein HEPN_RiboL-PSP PF18735.1 OPL21566.1 - 0.034 14.1 2.1 0.28 11.1 0.1 2.3 2 0 0 2 2 2 0 RiboL-PSP-HEPN MreB_Mbl PF06723.13 OPL21566.1 - 0.063 12.1 0.2 0.28 10.0 0.2 2.0 2 1 0 2 2 2 0 MreB/Mbl protein Lectin_C PF00059.21 OPL21567.1 - 2.1e-05 25.2 3.4 2.7e-05 24.8 3.4 1.1 1 0 0 1 1 1 1 Lectin C-type domain p450 PF00067.22 OPL21568.1 - 3.1e-29 102.0 0.2 3.8e-29 101.8 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 FPL PF09758.9 OPL21569.1 - 1.5e-25 90.0 3.6 1.5e-25 90.0 3.6 1.7 2 0 0 2 2 2 1 Uncharacterised conserved protein JHD PF17811.1 OPL21569.1 - 0.032 14.7 0.0 0.063 13.8 0.0 1.5 1 0 0 1 1 1 0 Jumonji helical domain Cep57_CLD_2 PF14197.6 OPL21570.1 - 0.00031 20.8 3.2 0.00031 20.8 3.2 2.5 1 1 1 2 2 2 1 Centrosome localisation domain of PPC89 FAM76 PF16046.5 OPL21570.1 - 0.15 11.4 15.4 1.6 8.0 15.4 2.0 1 1 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 OPL21570.1 - 0.39 10.0 3.3 0.44 9.9 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 OPL21570.1 - 1.2 8.7 8.1 1.7 8.1 8.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ras PF00071.22 OPL21571.1 - 4.2e-24 85.0 0.1 5e-24 84.7 0.1 1.0 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 OPL21571.1 - 3.2e-09 36.9 0.0 4.6e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 OPL21571.1 - 7.1e-08 32.7 0.0 1.3e-07 31.9 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 OPL21571.1 - 3.7e-06 26.5 0.0 4.5e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.23 OPL21571.1 - 0.00045 20.3 0.1 0.31 11.1 0.0 2.3 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 OPL21571.1 - 0.0013 18.2 0.1 0.0021 17.5 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 OPL21571.1 - 0.005 16.4 0.1 1.5 8.3 0.0 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 OPL21571.1 - 0.0053 16.7 0.6 0.55 10.1 0.1 2.7 2 1 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 OPL21571.1 - 0.015 14.7 0.1 0.018 14.4 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 OPL21571.1 - 0.023 14.2 0.9 0.12 11.9 0.9 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Autophagy_C PF10381.9 OPL21571.1 - 0.027 14.0 1.2 0.051 13.1 1.2 1.5 1 0 0 1 1 1 0 Autophagocytosis associated protein C-terminal Septin PF00735.18 OPL21571.1 - 0.033 13.5 0.1 0.083 12.2 0.1 1.6 1 1 0 1 1 1 0 Septin AAA_29 PF13555.6 OPL21571.1 - 0.04 13.7 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain XRN1_D2_D3 PF18334.1 OPL21571.1 - 0.054 13.7 0.0 2 8.7 0.0 2.6 1 1 1 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain KR PF08659.10 OPL21572.1 - 5.6e-50 169.8 0.0 1e-49 168.9 0.0 1.4 1 0 0 1 1 1 1 KR domain PP-binding PF00550.25 OPL21572.1 - 5.2e-07 29.9 0.2 1.3e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 OPL21572.1 - 3e-06 26.9 0.0 6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 OPL21572.1 - 3.4e-06 26.7 0.0 8.6e-06 25.3 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase DELLA PF12041.8 OPL21572.1 - 0.042 13.7 0.1 0.19 11.6 0.0 2.2 2 0 0 2 2 2 0 Transcriptional regulator DELLA protein N terminal bPH_5 PF10882.8 OPL21572.1 - 0.2 11.8 0.9 0.87 9.7 0.1 2.2 2 0 0 2 2 2 0 Bacterial PH domain Cadherin PF00028.17 OPL21573.1 - 1.4e-38 131.2 23.6 5.4e-11 42.8 0.2 6.6 6 1 0 6 6 6 6 Cadherin domain DMAP1 PF05499.12 OPL21574.1 - 0.012 15.5 4.5 0.018 15.0 4.5 1.3 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) CytochromB561_N PF09786.9 OPL21574.1 - 0.037 13.0 0.5 0.043 12.8 0.5 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal PDZ PF00595.24 OPL21575.1 - 0.1 13.0 0.1 0.2 12.0 0.1 1.5 1 0 0 1 1 1 0 PDZ domain POR_N PF01855.19 OPL21575.1 - 0.14 11.9 0.7 0.24 11.1 0.7 1.3 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg AMP-binding PF00501.28 OPL21576.1 - 7.7e-17 61.0 0.7 3.4e-16 58.8 0.7 1.8 1 1 0 1 1 1 1 AMP-binding enzyme LPMO_10 PF03067.15 OPL21578.1 - 8.2e-28 98.4 0.2 8.2e-28 98.4 0.2 1.5 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Mucin PF01456.17 OPL21578.1 - 0.0011 18.9 16.3 0.0019 18.2 16.3 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein C1q PF00386.21 OPL21579.1 - 4.3e-05 23.7 0.5 0.00013 22.1 0.0 1.9 2 0 0 2 2 2 1 C1q domain RapA_C PF12137.8 OPL21579.1 - 0.0011 18.1 2.2 0.0014 17.7 2.2 1.2 1 0 0 1 1 1 1 RNA polymerase recycling family C-terminal Mitofilin PF09731.9 OPL21579.1 - 0.012 14.4 1.6 0.015 14.2 1.6 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Imm58 PF15581.6 OPL21579.1 - 0.028 14.5 0.1 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Immunity protein 58 DUF2357 PF09823.9 OPL21579.1 - 0.052 12.8 1.0 0.076 12.3 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) AKNA PF12443.8 OPL21579.1 - 0.067 13.9 1.1 0.13 12.9 0.4 1.8 1 1 1 2 2 2 0 AT-hook-containing transcription factor DUF1690 PF07956.11 OPL21579.1 - 0.069 13.6 3.1 0.12 12.7 3.1 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Ribosomal_S28e PF01200.18 OPL21580.1 - 1.8e-31 107.9 0.7 2.8e-31 107.3 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S28e DpnI_C PF17726.1 OPL21581.1 - 0.033 14.3 0.0 0.066 13.4 0.0 1.5 1 0 0 1 1 1 0 Dam-replacing HTH domain RhoGEF PF00621.20 OPL21582.1 - 6.7e-16 59.1 0.2 1.1e-15 58.4 0.2 1.3 1 0 0 1 1 1 1 RhoGEF domain Histone PF00125.24 OPL21582.1 - 0.07 13.5 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 LRR19-TM PF15176.6 OPL21583.1 - 0.055 13.5 1.1 0.1 12.6 0.2 1.9 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain TMEM132D_C PF15706.5 OPL21583.1 - 0.12 12.2 0.2 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4690 PF15756.5 OPL21583.1 - 0.21 12.2 0.0 0.33 11.6 0.0 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage PRIMA1 PF16101.5 OPL21583.1 - 3.9 7.5 5.4 0.37 10.8 0.6 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 zf-CCCH_3 PF15663.5 OPL21587.1 - 3.4e-28 98.0 8.6 3.7e-28 98.0 8.6 1.0 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 OPL21587.1 - 6.5e-05 23.3 26.3 0.4 11.2 5.3 4.1 3 1 0 3 3 3 3 RNA-binding, Nab2-type zinc finger Torus PF16131.5 OPL21587.1 - 0.016 15.9 6.9 0.1 13.3 6.9 2.1 1 1 0 1 1 1 0 Torus domain zf_CCCH_4 PF18345.1 OPL21587.1 - 0.31 11.1 25.7 0.19 11.8 7.1 4.9 4 1 0 4 4 4 0 Zinc finger domain DBD_Tnp_Mut PF03108.15 OPL21587.1 - 1.6 8.8 10.0 3.3 7.8 0.6 3.2 3 0 0 3 3 3 0 MuDR family transposase zf-CCCH PF00642.24 OPL21587.1 - 6.5 6.8 24.5 0.15 12.0 1.8 4.1 3 1 1 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HAUS-augmin3 PF14932.6 OPL21588.1 - 0.057 13.0 6.2 0.085 12.4 6.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 MU117 PF15474.6 OPL21588.1 - 0.55 11.1 4.2 1.6 9.5 4.2 1.9 1 1 0 1 1 1 0 Meiotically up-regulated gene family Sema PF01403.19 OPL21589.1 - 3.9e-08 32.5 0.2 5.2e-08 32.1 0.2 1.1 1 0 0 1 1 1 1 Sema domain TusA PF01206.17 OPL21589.1 - 0.15 11.9 0.0 7.3 6.5 0.0 2.5 2 0 0 2 2 2 0 Sulfurtransferase TusA DUF5313 PF17240.2 OPL21590.1 - 8.4e-12 45.6 11.3 1.1 9.8 0.0 6.7 5 2 2 7 7 7 5 Family of unknown function (DUF5313) TSP_1 PF00090.19 OPL21590.1 - 0.00043 20.4 19.5 1.6 9.0 0.1 6.7 7 0 0 7 7 7 3 Thrombospondin type 1 domain IBV_3C PF03620.13 OPL21590.1 - 0.58 10.7 2.4 47 4.5 0.0 4.1 5 1 1 6 6 6 0 IBV 3C protein Polyketide_cyc2 PF10604.9 OPL21590.1 - 0.71 10.1 10.2 33 4.7 0.1 5.2 4 2 0 6 6 6 0 Polyketide cyclase / dehydrase and lipid transport Ank_4 PF13637.6 OPL21591.1 - 7e-08 32.9 0.4 8.6e-05 23.0 0.1 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL21591.1 - 2.3e-05 24.4 3.0 0.0052 17.2 0.2 3.9 4 0 0 4 4 4 1 Ankyrin repeat Ank_2 PF12796.7 OPL21591.1 - 0.00073 20.1 0.1 0.0029 18.2 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) SOCS_box PF07525.16 OPL21591.1 - 0.00099 19.4 0.0 0.0022 18.3 0.0 1.6 1 0 0 1 1 1 1 SOCS box Ank PF00023.30 OPL21591.1 - 0.03 14.8 0.4 11 6.7 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat FliC PF12445.8 OPL21592.1 - 0.091 13.1 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 Flagellin protein Fascin PF06268.13 OPL21594.1 - 4.8e-72 239.3 9.6 2.6e-26 92.0 0.3 4.1 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.12 OPL21594.1 - 3.9e-18 65.9 1.5 0.0057 16.4 0.0 6.3 2 2 3 6 6 6 4 FRG1-like domain RicinB_lectin_2 PF14200.6 OPL21594.1 - 7.4e-05 23.4 6.8 0.25 12.1 0.2 4.7 3 1 0 4 4 4 2 Ricin-type beta-trefoil lectin domain-like DUF569 PF04601.13 OPL21594.1 - 0.00062 19.5 1.3 0.16 11.7 0.0 4.1 4 1 2 6 6 6 1 Domain of unknown function (DUF569) Mito_carr PF00153.27 OPL21596.1 - 5.8e-29 99.9 0.1 1.2e-19 70.0 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein CBM_15 PF03426.14 OPL21596.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 15) Ephrin_rec_like PF07699.13 OPL21597.1 - 6e-06 25.9 9.7 6e-06 25.9 9.7 7.3 5 3 2 7 7 7 3 Putative ephrin-receptor like TNFR_c6 PF00020.18 OPL21597.1 - 0.035 14.5 6.4 0.035 14.5 6.4 7.8 6 2 2 8 8 8 0 TNFR/NGFR cysteine-rich region TMEM154 PF15102.6 OPL21599.1 - 0.00014 21.7 0.6 0.00014 21.7 0.6 3.1 1 1 1 3 3 3 1 TMEM154 protein family Adeno_E3_CR2 PF02439.15 OPL21599.1 - 0.017 14.9 6.7 0.029 14.1 6.7 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SUIM_assoc PF16619.5 OPL21599.1 - 0.25 11.5 12.4 0.062 13.4 7.7 2.4 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Myc_target_1 PF15179.6 OPL21599.1 - 0.54 10.1 6.4 3 7.7 0.0 2.3 1 1 1 2 2 2 0 Myc target protein 1 Neur_chan_memb PF02932.16 OPL21599.1 - 1.4 8.9 16.2 0.067 13.2 9.3 1.9 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region EphA2_TM PF14575.6 OPL21599.1 - 2 9.4 13.5 33 5.5 13.5 3.0 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Cadherin_C_2 PF16492.5 OPL21599.1 - 5 7.9 5.2 25 5.7 5.2 2.5 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal BLACT_WH PF17778.1 OPL21600.1 - 7.1e-06 25.9 0.3 9.3e-06 25.5 0.3 1.2 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain RE_NgoPII PF09521.10 OPL21600.1 - 0.0063 15.7 0.1 0.0072 15.5 0.1 1.1 1 0 0 1 1 1 1 NgoPII restriction endonuclease DUF1398 PF07166.11 OPL21600.1 - 0.042 13.9 0.0 0.049 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1398) GCP_N_terminal PF17681.1 OPL21601.1 - 8.8e-49 166.8 0.6 8.4e-37 127.4 0.1 2.1 1 1 1 2 2 2 2 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 OPL21601.1 - 3.7e-20 72.6 2.0 4e-20 72.5 0.5 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal Phage_TAC_5 PF08890.11 OPL21601.1 - 0.12 12.4 0.4 0.33 11.0 0.4 1.7 1 1 0 1 1 1 0 Phage XkdN-like tail assembly chaperone protein, TAC Ion_trans_2 PF07885.16 OPL21602.1 - 4.7e-22 77.8 13.7 4e-15 55.5 6.8 2.2 2 0 0 2 2 2 2 Ion channel Robl_LC7 PF03259.17 OPL21603.1 - 4e-28 97.0 0.0 4.4e-28 96.9 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 OPL21603.1 - 0.0002 21.2 0.0 0.00026 20.8 0.0 1.2 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 UPF0176_N PF17773.1 OPL21603.1 - 0.0094 16.3 0.0 0.012 16.0 0.0 1.1 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain PMSI1 PF15322.6 OPL21604.1 - 0.0039 16.7 0.3 0.004 16.7 0.3 1.0 1 0 0 1 1 1 1 Protein missing in infertile sperm 1, putative Toxin_11 PF07473.11 OPL21604.1 - 0.15 12.2 7.5 0.23 11.6 7.5 1.3 1 0 0 1 1 1 0 Spasmodic peptide gm9a; conotoxin from Conus species DASH_Hsk3 PF08227.11 OPL21606.1 - 0.26 11.7 0.2 0.26 11.7 0.2 1.9 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like C1q PF00386.21 OPL21607.1 - 5.1e-17 62.3 0.2 7.2e-17 61.8 0.2 1.2 1 0 0 1 1 1 1 C1q domain Tup_N PF08581.10 OPL21607.1 - 0.032 14.5 0.1 0.048 14.0 0.1 1.2 1 0 0 1 1 1 0 Tup N-terminal PA14 PF07691.12 OPL21607.1 - 0.051 13.4 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 PA14 domain WAP PF00095.21 OPL21608.1 - 2.3e-05 24.7 16.7 2.3e-05 24.7 16.7 2.3 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Death PF00531.22 OPL21609.1 - 6.4e-11 42.3 0.4 0.00041 20.5 0.0 2.3 2 0 0 2 2 2 2 Death domain M16C_assoc PF08367.11 OPL21609.1 - 0.12 11.5 0.1 0.2 10.8 0.1 1.3 1 0 0 1 1 1 0 Peptidase M16C associated C1q PF00386.21 OPL21611.1 - 1.8e-19 70.2 0.5 2.2e-19 69.9 0.5 1.1 1 0 0 1 1 1 1 C1q domain SH3_2 PF07653.17 OPL21611.1 - 0.091 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain TrkA_TMD PF18613.1 OPL21611.1 - 0.15 11.5 0.1 0.25 10.8 0.1 1.3 1 0 0 1 1 1 0 Tyrosine kinase receptor A trans-membrane domain Lig_chan PF00060.26 OPL21612.1 - 2e-20 73.2 0.1 2.7e-20 72.7 0.1 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 OPL21612.1 - 0.00071 19.1 0.0 0.00085 18.8 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Antimicrobial_8 PF08103.11 OPL21613.1 - 0.15 12.2 1.2 0.41 10.9 1.2 1.7 1 0 0 1 1 1 0 Uperin family SMODS PF18144.1 OPL21615.1 - 4.6e-06 26.9 0.0 5.3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain NTP_transf_2 PF01909.23 OPL21615.1 - 0.0001 22.6 0.1 0.00013 22.2 0.1 1.2 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF2312 PF10073.9 OPL21615.1 - 0.00075 19.1 0.1 0.015 15.0 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2312) Defensin_big PF14862.6 OPL21616.1 - 0.00023 21.4 0.0 0.00037 20.7 0.0 1.3 1 0 0 1 1 1 1 Big defensin TraL PF07178.11 OPL21616.1 - 0.013 15.9 0.7 0.016 15.7 0.7 1.1 1 0 0 1 1 1 0 TraL protein zf-PARP PF00645.18 OPL21616.1 - 0.8 10.6 4.7 1.2 10.1 4.4 1.5 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region SEA PF01390.20 OPL21617.1 - 1.4e-15 57.3 1.1 1.4e-15 57.3 1.1 3.1 2 0 0 2 2 2 1 SEA domain EphA2_TM PF14575.6 OPL21617.1 - 0.047 14.6 0.0 0.11 13.4 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Mucin-like PF16058.5 OPL21617.1 - 0.062 13.4 44.1 0.4 10.8 5.3 5.3 2 2 2 4 4 4 0 Mucin-like DAP10 PF07213.11 OPL21617.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 DAP10 membrane protein Drf_FH1 PF06346.12 OPL21617.1 - 3.8 7.2 25.6 0.17 11.6 0.6 4.6 2 1 2 5 5 5 0 Formin Homology Region 1 BTB PF00651.31 OPL21618.1 - 2.2e-13 50.4 0.9 4.8e-13 49.3 0.9 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 OPL21618.1 - 7.8e-05 22.9 3.3 0.0023 18.3 1.8 8.2 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 OPL21618.1 - 0.0013 19.4 62.7 0.042 14.7 2.3 8.7 8 0 0 8 8 8 4 C2H2-type zinc finger zf-Di19 PF05605.12 OPL21618.1 - 0.0031 17.8 25.1 0.54 10.6 0.6 5.3 3 2 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 OPL21618.1 - 0.016 15.7 3.3 0.016 15.7 3.3 8.4 8 0 0 8 8 8 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 OPL21618.1 - 0.2 11.7 32.3 0.42 10.7 0.3 7.4 8 0 0 8 8 8 0 C2H2-type zinc finger RbsD_FucU PF05025.13 OPL21619.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 RbsD / FucU transport protein family Kringle PF00051.18 OPL21622.1 - 1.3e-09 38.3 2.7 1.3e-09 38.3 2.7 2.0 1 1 1 2 2 2 1 Kringle domain KH_1 PF00013.29 OPL21624.1 - 2.1e-07 30.7 0.0 4.2e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 KH domain DUF5600 PF18150.1 OPL21624.1 - 0.083 13.5 0.2 0.4 11.3 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5600) BAR_2 PF10455.9 OPL21624.1 - 0.25 10.4 2.7 0.45 9.6 2.8 1.6 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking COR PF16095.5 OPL21625.1 - 2.3e-17 63.4 0.2 5.8e-17 62.1 0.2 1.7 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain CARD PF00619.21 OPL21625.1 - 7.1e-10 38.8 0.2 2.1e-09 37.3 0.2 1.7 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 OPL21625.1 - 1.3e-07 31.5 0.1 3.7e-07 30.0 0.1 1.7 1 0 0 1 1 1 1 Caspase recruitment domain DrrA_P4M PF14860.6 OPL21625.1 - 3.5 7.5 5.5 2.4 8.1 0.3 3.1 4 0 0 4 4 4 0 DrrA phosphatidylinositol 4-phosphate binding domain eIF_4EBP PF05456.11 OPL21626.1 - 0.00088 19.2 0.0 0.00088 19.2 0.0 3.3 3 1 0 3 3 3 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Mtc PF03820.17 OPL21627.1 - 5.8e-48 163.5 0.6 6.5e-48 163.4 0.6 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier SAM_1 PF00536.30 OPL21628.1 - 1.2e-13 51.2 0.0 2.6e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 OPL21628.1 - 7e-11 42.1 0.1 1.6e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF5128 PF17170.4 OPL21629.1 - 0.0081 15.3 0.0 0.017 14.3 0.0 1.6 1 1 0 1 1 1 1 6-bladed beta-propeller Coatomer_WDAD PF04053.14 OPL21629.1 - 0.041 12.9 0.1 0.69 8.9 0.0 2.0 2 0 0 2 2 2 0 Coatomer WD associated region PND PF17949.1 OPL21629.1 - 0.094 13.0 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 FANCM pseudonuclease domain cobW PF02492.19 OPL21631.1 - 4.3e-31 107.9 0.0 5.2e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 OPL21631.1 - 4e-06 26.0 0.1 0.0044 16.0 0.1 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 OPL21631.1 - 0.021 15.3 0.0 0.034 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 OPL21631.1 - 0.026 15.0 0.0 0.21 12.0 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 OPL21631.1 - 0.033 14.2 0.0 0.055 13.5 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 OPL21631.1 - 0.044 14.2 0.0 18 5.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.6 OPL21631.1 - 0.049 14.0 0.0 0.088 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 OPL21631.1 - 0.05 12.8 0.0 0.08 12.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain ABC_tran PF00005.27 OPL21631.1 - 0.16 12.5 0.0 0.39 11.2 0.0 1.7 2 0 0 2 2 2 0 ABC transporter Ion_trans_2 PF07885.16 OPL21632.1 - 7.1e-13 48.3 7.9 7.1e-13 48.3 7.9 1.9 2 1 0 2 2 2 1 Ion channel Ion_trans PF00520.31 OPL21632.1 - 0.0026 17.0 15.2 0.0049 16.1 15.2 1.4 1 1 0 1 1 1 1 Ion transport protein Lig_chan PF00060.26 OPL21632.1 - 0.24 11.2 2.7 0.3 10.9 2.0 1.5 1 1 0 1 1 1 0 Ligand-gated ion channel BK_channel_a PF03493.18 OPL21633.1 - 7e-13 48.6 0.0 1.5e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit GMC_oxred_N PF00732.19 OPL21634.1 - 1.5e-34 119.8 0.0 1.7e-34 119.5 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 OPL21634.1 - 0.0011 19.1 0.7 0.0024 18.1 0.7 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 OPL21634.1 - 0.017 14.2 0.1 0.023 13.8 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 OPL21634.1 - 0.082 11.6 0.1 0.12 11.0 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein DAO PF01266.24 OPL21634.1 - 0.11 12.1 0.6 0.14 11.8 0.6 1.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase HSP70 PF00012.20 OPL21635.1 - 1.1e-94 317.8 0.7 1.3e-94 317.5 0.7 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL21635.1 - 9.2e-07 28.0 0.0 1.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Ppx-GppA PF02541.16 OPL21635.1 - 0.00048 19.7 0.0 0.00084 18.9 0.0 1.4 1 0 0 1 1 1 1 Ppx/GppA phosphatase family DDR PF08841.10 OPL21635.1 - 0.011 14.8 0.1 0.043 12.8 0.1 1.9 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain FtsA PF14450.6 OPL21635.1 - 0.13 12.7 0.0 0.38 11.2 0.0 1.8 1 1 0 1 1 1 0 Cell division protein FtsA DUF641 PF04859.12 OPL21635.1 - 4.8 7.5 6.6 0.67 10.3 1.1 2.3 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) FadA PF09403.10 OPL21635.1 - 5.9 7.4 8.5 18 5.9 2.0 3.0 2 0 0 2 2 2 0 Adhesion protein FadA Cys_Met_Meta_PP PF01053.20 OPL21636.1 - 1.3e-132 441.9 0.3 1.6e-132 441.7 0.3 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.11 OPL21636.1 - 5.6e-08 31.7 0.1 8e-08 31.2 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_1_2 PF00155.21 OPL21636.1 - 1.4e-07 31.1 0.3 2e-07 30.5 0.3 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II GDC-P PF02347.16 OPL21636.1 - 0.0023 16.8 0.3 0.0032 16.3 0.3 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein RHH_5 PF07878.11 OPL21636.1 - 0.17 11.8 0.0 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 Ig_3 PF13927.6 OPL21637.1 - 0.0027 18.3 0.1 0.016 15.8 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin domain Peptidase_M13 PF01431.21 OPL21638.1 - 1.5e-22 80.2 0.0 1.6e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 EF-hand_6 PF13405.6 OPL21639.1 - 5.1e-05 22.9 1.1 0.11 12.5 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 OPL21639.1 - 0.00027 20.3 0.0 1.1 8.9 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 OPL21639.1 - 0.00064 20.1 0.3 0.0026 18.2 0.3 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 OPL21639.1 - 0.0035 16.8 0.6 1.9 8.1 0.1 2.8 2 1 0 2 2 2 2 EF hand EGF PF00008.27 OPL21640.1 - 2.8e-10 40.3 38.8 4.9e-07 29.9 7.1 4.0 4 0 0 4 4 4 3 EGF-like domain EGF_CA PF07645.15 OPL21640.1 - 4.4e-08 33.2 42.9 7.2e-07 29.3 11.4 3.5 2 1 1 3 3 3 2 Calcium-binding EGF domain FXa_inhibition PF14670.6 OPL21640.1 - 3.3e-05 24.1 6.9 3.3e-05 24.1 6.9 3.9 2 1 1 3 3 3 1 Coagulation Factor Xa inhibitory site hEGF PF12661.7 OPL21640.1 - 6e-05 23.5 17.2 9.5e-05 22.9 5.0 5.8 5 1 1 6 6 6 3 Human growth factor-like EGF EGF_3 PF12947.7 OPL21640.1 - 0.00021 21.4 32.5 0.0022 18.2 7.0 3.8 2 1 1 3 3 3 2 EGF domain EGF_2 PF07974.13 OPL21640.1 - 0.0013 19.1 9.3 0.0013 19.1 9.3 3.9 3 1 0 3 3 3 2 EGF-like domain AAA_21 PF13304.6 OPL21641.1 - 0.001 18.9 0.0 0.0016 18.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF870 PF05912.11 OPL21641.1 - 0.071 13.1 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF870) CelTOS PF18659.1 OPL21641.1 - 0.079 13.4 0.1 0.33 11.4 0.0 1.9 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites FlgN PF05130.12 OPL21642.1 - 0.043 14.3 0.1 0.49 10.9 0.0 2.0 1 1 1 2 2 2 0 FlgN protein Spectrin PF00435.21 OPL21642.1 - 0.083 13.4 0.9 9.3 6.8 0.1 2.9 2 1 1 3 3 3 0 Spectrin repeat IL4 PF00727.18 OPL21642.1 - 0.086 13.1 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Interleukin 4 Methyltransf_33 PF10017.9 OPL21643.1 - 1.2e-52 179.0 0.3 1.6e-52 178.6 0.3 1.1 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_25 PF13649.6 OPL21643.1 - 0.064 14.0 0.0 0.2 12.4 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Atrophin-1 PF03154.15 OPL21643.1 - 0.12 10.6 1.3 0.16 10.2 1.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.6 OPL21643.1 - 3.8 7.5 6.3 4 7.4 5.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) MIEAP PF16026.5 OPL21644.1 - 1.1e-17 64.9 0.0 1.2e-17 64.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondria-eating protein SNF PF00209.18 OPL21647.1 - 6.6e-26 91.1 5.4 7.6e-26 90.9 5.4 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Rapsyn_N PF10579.9 OPL21647.1 - 0.14 12.3 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region C2-set_2 PF08205.12 OPL21648.1 - 1.3e-07 31.6 0.2 0.016 15.2 0.1 3.2 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 OPL21648.1 - 1.2e-05 25.6 0.3 0.00046 20.5 0.1 2.2 1 1 1 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 OPL21648.1 - 2.4e-05 24.8 0.1 0.026 15.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL21648.1 - 3.1e-05 24.1 0.0 0.011 15.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Stanniocalcin PF03298.13 OPL21650.1 - 0.0015 17.9 6.8 0.0021 17.4 6.8 1.1 1 0 0 1 1 1 1 Stanniocalcin family CNH PF00780.22 OPL21651.1 - 4.9e-12 46.0 0.2 7.3e-12 45.5 0.2 1.1 1 0 0 1 1 1 1 CNH domain PH PF00169.29 OPL21651.1 - 0.0035 17.8 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 PH domain DUF2332 PF10094.9 OPL21651.1 - 0.012 15.0 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2332) DUF5096 PF17019.5 OPL21651.1 - 0.036 13.9 0.1 0.073 12.8 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5096) Glyco_hydro_106 PF17132.4 OPL21651.1 - 0.19 9.9 0.0 0.38 9.0 0.0 1.4 2 0 0 2 2 2 0 alpha-L-rhamnosidase Snapin_Pallidin PF14712.6 OPL21653.1 - 0.0092 16.4 1.2 0.02 15.3 1.2 1.6 1 0 0 1 1 1 1 Snapin/Pallidin ArnB_C PF18677.1 OPL21653.1 - 0.088 12.9 3.2 0.16 12.1 3.2 1.6 1 1 0 1 1 1 0 Archaellum regulatory network B, C-terminal domain Fzo_mitofusin PF04799.13 OPL21653.1 - 4 7.0 6.7 23 4.5 6.7 2.1 1 1 0 1 1 1 0 fzo-like conserved region fn3 PF00041.21 OPL21654.1 - 9.9e-06 25.8 0.0 2.7e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain Mntp PF02659.15 OPL21654.1 - 0.05 13.4 0.0 0.088 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative manganese efflux pump Pur_ac_phosph_N PF16656.5 OPL21654.1 - 0.073 13.7 0.3 0.073 13.7 0.3 2.6 2 2 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain SPOC PF07744.13 OPL21655.1 - 3.8e-33 114.5 0.0 1.3e-32 112.8 0.0 1.8 2 0 0 2 2 2 1 SPOC domain RRM_1 PF00076.22 OPL21655.1 - 3.5e-29 100.4 0.0 9.8e-14 50.9 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 OPL21655.1 - 8.4e-08 32.2 0.0 0.044 13.9 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif RRM_3 PF08777.11 OPL21655.1 - 6.8e-05 22.9 0.0 0.012 15.7 0.0 3.1 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 OPL21655.1 - 0.039 13.9 0.6 0.36 10.9 0.0 2.6 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif DUF2689 PF10894.8 OPL21655.1 - 0.4 10.5 1.4 51 3.8 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2689) MMS1_N PF10433.9 OPL21656.1 - 1.9e-35 122.5 0.0 4.8e-35 121.1 0.0 1.7 3 0 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 OPL21656.1 - 1.5e-30 106.7 0.0 2.5e-30 105.9 0.0 1.4 1 0 0 1 1 1 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 OPL21656.1 - 0.067 13.5 0.0 1.8 8.9 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ATP-synt_ab_N PF02874.23 OPL21656.1 - 0.11 13.1 0.0 0.33 11.5 0.0 1.8 1 0 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain PHR PF08005.12 OPL21657.1 - 2.8e-17 63.8 0.2 7.9e-17 62.3 0.0 1.8 2 0 0 2 2 2 1 PHR domain BTB PF00651.31 OPL21657.1 - 5.5e-10 39.5 3.7 4.5e-05 23.7 0.3 3.3 1 1 2 3 3 3 2 BTB/POZ domain BACK PF07707.15 OPL21657.1 - 1.7e-05 24.9 0.9 5.4e-05 23.2 0.9 1.9 1 1 0 1 1 1 1 BTB And C-terminal Kelch DUF4082 PF13313.6 OPL21657.1 - 0.086 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) CBFD_NFYB_HMF PF00808.23 OPL21657.1 - 0.16 12.2 0.7 0.4 11.0 0.7 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone MIB_HERC2 PF06701.13 OPL21658.1 - 2.9e-14 53.1 9.4 2.3e-07 30.9 6.9 3.1 2 1 0 2 2 2 2 Mib_herc2 PhyH PF05721.13 OPL21659.1 - 0.024 14.9 0.0 0.026 14.8 0.0 1.1 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) Ofd1_CTDD PF10637.9 OPL21659.1 - 0.078 12.3 0.0 0.093 12.1 0.0 1.0 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term PhyH PF05721.13 OPL21660.1 - 6e-10 39.7 0.0 8.2e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 OPL21660.1 - 0.0042 17.5 0.0 0.0068 16.8 0.0 1.3 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 OPL21660.1 - 0.07 14.0 0.0 0.099 13.5 0.0 1.2 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily RCDG1 PF15725.5 OPL21660.1 - 0.084 13.3 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Ank_2 PF12796.7 OPL21661.1 - 4.1e-40 136.2 4.0 7.3e-18 64.9 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL21661.1 - 7.3e-30 103.0 4.0 1.5e-08 35.0 0.0 4.6 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL21661.1 - 1.8e-29 98.5 5.8 2.1e-06 27.6 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 OPL21661.1 - 1.1e-28 98.9 8.7 5.2e-08 33.0 0.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 OPL21661.1 - 4e-23 80.8 11.6 0.00011 22.4 0.0 5.9 5 1 1 6 6 6 5 Ankyrin repeat UPF0180 PF03698.13 OPL21661.1 - 0.067 13.4 0.0 0.24 11.6 0.0 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0180) ApeC PF16977.5 OPL21662.1 - 6.1e-59 199.4 7.0 9.5e-59 198.8 7.0 1.3 1 0 0 1 1 1 1 C-terminal domain of apextrin SAM_PNT PF02198.16 OPL21663.1 - 9.2e-18 64.0 0.6 5.6e-10 39.0 0.2 2.3 2 0 0 2 2 2 2 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 OPL21663.1 - 0.068 13.0 3.2 4 7.3 0.1 3.0 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 OPL21663.1 - 0.11 12.9 2.3 0.87 10.1 0.3 3.1 3 1 0 3 3 3 0 SAM domain (Sterile alpha motif) DUF3450 PF11932.8 OPL21664.1 - 0.098 11.9 1.7 0.26 10.6 1.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) THF_DHG_CYH_C PF02882.19 OPL21664.1 - 0.11 11.8 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain MPS2 PF17060.5 OPL21664.1 - 0.17 11.1 2.8 0.2 10.9 2.8 1.3 1 1 0 1 1 1 0 Monopolar spindle protein 2 AOX PF01786.17 OPL21665.1 - 1e-23 84.1 0.1 1.1e-23 84.0 0.1 1.0 1 0 0 1 1 1 1 Alternative oxidase Complex1_LYR PF05347.15 OPL21666.1 - 1e-17 63.9 0.1 1.8e-17 63.1 0.1 1.4 1 1 1 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 OPL21666.1 - 0.00029 21.4 0.1 0.0005 20.6 0.1 1.4 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.6 OPL21666.1 - 0.00056 20.6 0.3 0.00066 20.4 0.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like RSS_P20 PF11757.8 OPL21666.1 - 0.023 15.1 0.1 0.028 14.8 0.1 1.2 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain zf-CCCH_6 PF18585.1 OPL21666.1 - 0.1 12.5 0.2 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 DUF3490 PF11995.8 OPL21668.1 - 0.14 11.9 0.9 1.8 8.4 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3490) Tubulin PF00091.25 OPL21669.1 - 4.7e-66 222.8 0.0 7.4e-66 222.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 OPL21669.1 - 4.2e-43 146.5 0.1 7.2e-43 145.8 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 OPL21669.1 - 7.7e-05 23.0 0.0 0.0002 21.6 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 OPL21669.1 - 0.008 15.4 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 OPL21669.1 - 0.0087 15.8 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain TrmK PF04816.12 OPL21669.1 - 0.072 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase DUF948 PF06103.11 OPL21670.1 - 0.012 15.8 0.9 0.059 13.6 0.4 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) GST_C_3 PF14497.6 OPL21671.1 - 2.2e-18 66.3 0.2 2.6e-18 66.0 0.2 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 OPL21671.1 - 7.7e-12 45.3 0.1 1.1e-11 44.8 0.1 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 OPL21671.1 - 0.00029 20.6 0.1 0.0014 18.4 0.1 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 OPL21671.1 - 0.0012 18.8 0.0 0.0023 17.9 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ChAPs PF09295.10 OPL21671.1 - 0.14 11.2 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) AAA_16 PF13191.6 OPL21673.1 - 3.3e-07 30.8 0.0 4.2e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 OPL21673.1 - 9.3e-07 29.3 0.5 1.5e-06 28.6 0.5 1.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 OPL21673.1 - 3.2e-05 24.2 0.4 4.6e-05 23.7 0.4 1.3 1 1 0 1 1 1 1 AAA domain Ku_N PF03731.15 OPL21673.1 - 0.0024 17.6 0.8 0.0027 17.5 0.8 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain AAA_7 PF12775.7 OPL21673.1 - 0.0057 16.2 0.0 0.02 14.4 0.0 1.8 1 1 1 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 OPL21673.1 - 0.0076 16.4 0.2 0.016 15.4 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 OPL21673.1 - 0.0084 16.1 2.0 0.04 13.9 2.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 OPL21673.1 - 0.0094 16.5 0.2 0.014 15.9 0.2 1.4 1 1 0 1 1 1 1 ABC transporter NACHT PF05729.12 OPL21673.1 - 0.018 15.0 1.5 0.037 14.0 1.5 1.5 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 OPL21673.1 - 0.018 15.6 0.4 0.037 14.6 0.4 1.6 1 1 0 1 1 1 0 AAA domain PhosphMutase PF10143.9 OPL21673.1 - 0.026 14.4 0.5 0.046 13.6 0.5 1.5 1 1 0 1 1 1 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase AAA_23 PF13476.6 OPL21673.1 - 0.029 14.9 3.2 0.049 14.1 3.2 1.3 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 OPL21673.1 - 0.064 12.4 1.4 0.49 9.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 OPL21673.1 - 0.082 12.8 0.8 0.26 11.2 0.1 2.0 1 1 2 3 3 3 0 RsgA GTPase HipN PF18253.1 OPL21673.1 - 0.096 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Hsp70-interacting protein N N-terminal domain RNA_helicase PF00910.22 OPL21673.1 - 0.12 12.8 0.2 0.26 11.7 0.1 1.9 1 1 1 2 2 2 0 RNA helicase Methyltransf_31 PF13847.6 OPL21674.1 - 5.2e-27 94.5 0.0 7.1e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 OPL21674.1 - 1.8e-19 70.3 0.0 3.6e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 OPL21674.1 - 2.5e-18 66.6 0.0 3.9e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 OPL21674.1 - 1.7e-16 60.6 0.0 2.9e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 OPL21674.1 - 1.2e-14 54.5 0.0 1.5e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 OPL21674.1 - 5e-12 45.7 0.0 7.5e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 OPL21674.1 - 1.3e-09 37.7 0.0 1.7e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 OPL21674.1 - 4.5e-09 36.1 0.0 5.8e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 OPL21674.1 - 9.2e-08 31.7 0.0 7.7e-07 28.7 0.0 2.2 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 OPL21674.1 - 2.7e-07 30.2 0.0 5e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 Putative methyltransferase GCD14 PF08704.10 OPL21674.1 - 2.9e-07 30.4 0.0 4e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_32 PF13679.6 OPL21674.1 - 6.2e-06 26.3 0.0 7.7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 OPL21674.1 - 1.9e-05 24.6 0.0 0.00017 21.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 OPL21674.1 - 2e-05 23.8 0.0 2.5e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase NodS PF05401.11 OPL21674.1 - 2.7e-05 23.9 0.0 3.9e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_16 PF10294.9 OPL21674.1 - 5.8e-05 22.9 0.0 7.6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase FtsJ PF01728.19 OPL21674.1 - 7e-05 23.0 0.0 8.8e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 OPL21674.1 - 7.9e-05 22.0 0.0 0.00011 21.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltr_RsmB-F PF01189.17 OPL21674.1 - 0.00049 19.8 0.0 0.0011 18.6 0.0 1.5 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F MetW PF07021.12 OPL21674.1 - 0.00057 19.5 0.0 0.00096 18.8 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Spermine_synth PF01564.17 OPL21674.1 - 0.00093 18.7 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain UPF0020 PF01170.18 OPL21674.1 - 0.0041 16.8 0.0 0.006 16.3 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 TehB PF03848.14 OPL21674.1 - 0.0071 15.8 0.0 0.01 15.3 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_15 PF09445.10 OPL21674.1 - 0.0075 15.9 0.0 0.016 14.7 0.0 1.6 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase ADH_zinc_N PF00107.26 OPL21674.1 - 0.01 15.8 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase rRNA_methylase PF06962.12 OPL21674.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.5 2 0 0 2 2 1 0 Putative rRNA methylase DREV PF05219.12 OPL21674.1 - 0.028 13.5 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Ribos_L4_asso_C PF14374.6 OPL21674.1 - 0.03 14.4 0.1 0.09 12.9 0.0 1.8 2 0 0 2 2 1 0 60S ribosomal protein L4 C-terminal domain PCMT PF01135.19 OPL21674.1 - 0.056 13.2 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CheR PF01739.18 OPL21674.1 - 0.057 12.9 0.0 0.23 10.9 0.0 1.8 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain FmrO PF07091.11 OPL21674.1 - 0.077 12.5 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_5 PF01795.19 OPL21674.1 - 0.092 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 MraW methylase family DUF938 PF06080.12 OPL21674.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) GidB PF02527.15 OPL21674.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G TIR_2 PF13676.6 OPL21675.1 - 4.6e-20 72.4 0.1 7.1e-20 71.8 0.1 1.3 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 OPL21675.1 - 3.8e-16 59.4 0.7 5.2e-16 58.9 0.7 1.1 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.11 OPL21675.1 - 6.8e-05 23.2 1.3 0.00027 21.2 1.3 1.9 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) CUB PF00431.20 OPL21676.1 - 1.1e-18 67.5 0.0 1.5e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 CUB domain IU_nuc_hydro PF01156.19 OPL21677.1 - 7.7e-81 272.0 0.2 8.7e-81 271.8 0.2 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase adh_short PF00106.25 OPL21678.1 - 1.2e-35 122.8 0.0 1.5e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL21678.1 - 7.9e-26 91.0 0.0 9.8e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 OPL21678.1 - 1.3e-08 35.0 0.0 1.6e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 OPL21678.1 - 0.0017 17.7 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DUF745 PF05335.13 OPL21679.1 - 2.1e-05 24.3 12.8 2.1e-05 24.3 12.8 3.3 2 1 0 3 3 3 1 Protein of unknown function (DUF745) EzrA PF06160.12 OPL21679.1 - 0.00051 18.4 16.7 0.00051 18.4 16.7 2.5 2 1 1 3 3 3 1 Septation ring formation regulator, EzrA ATG16 PF08614.11 OPL21679.1 - 0.0042 17.3 22.4 0.0042 17.3 22.4 3.4 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Tropomyosin PF00261.20 OPL21679.1 - 0.006 16.0 18.5 0.006 16.0 18.5 3.0 2 1 0 2 2 2 1 Tropomyosin APS_kinase PF01583.20 OPL21679.1 - 0.48 10.3 3.7 0.24 11.3 0.8 2.0 2 1 0 2 2 2 0 Adenylylsulphate kinase Laminin_II PF06009.12 OPL21679.1 - 6.3 6.8 36.1 0.61 10.1 9.3 3.7 2 1 2 4 4 4 0 Laminin Domain II Exonuc_VII_L PF02601.15 OPL21679.1 - 6.9 6.1 37.8 0.13 11.8 18.1 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit KxDL PF10241.9 OPL21680.1 - 0.0018 18.5 1.3 0.0064 16.7 1.3 2.0 1 0 0 1 1 1 1 Uncharacterized conserved protein DDHD PF02862.17 OPL21680.1 - 0.026 14.7 2.5 0.24 11.5 0.6 2.1 2 0 0 2 2 2 0 DDHD domain GntR PF00392.21 OPL21680.1 - 0.071 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Connexin PF00029.19 OPL21680.1 - 0.26 11.0 2.1 0.37 10.5 2.1 1.3 1 0 0 1 1 1 0 Connexin Kelch_6 PF13964.6 OPL21680.1 - 0.27 11.6 0.6 1.9 8.9 0.0 2.6 3 0 0 3 3 3 0 Kelch motif DUF1043 PF06295.12 OPL21680.1 - 2.2 8.3 10.6 1.7 8.6 8.3 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) Jak1_Phl PF17887.1 OPL21680.1 - 5.7 6.9 9.1 15 5.5 9.1 1.7 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain TPR_2 PF07719.17 OPL21681.1 - 3.2e-25 86.1 0.0 8.5e-07 28.6 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 OPL21681.1 - 1.8e-22 77.6 0.0 0.00011 22.1 0.0 5.7 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 OPL21681.1 - 2.2e-21 74.7 1.3 6.3e-08 32.1 0.0 5.7 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 OPL21681.1 - 6.7e-20 70.0 4.0 4.1e-07 29.9 0.0 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 OPL21681.1 - 3.4e-19 68.2 0.1 3e-11 42.8 0.0 6.1 4 1 2 6 6 6 3 TPR repeat TPR_19 PF14559.6 OPL21681.1 - 3e-16 59.7 0.0 7.3e-09 36.0 0.0 4.2 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 OPL21681.1 - 2.5e-14 53.6 0.0 7e-09 36.2 0.0 4.0 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 OPL21681.1 - 1.4e-13 50.4 0.0 0.023 15.5 0.0 6.1 2 1 4 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 OPL21681.1 - 3.6e-13 49.2 0.0 0.0077 16.8 0.0 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 OPL21681.1 - 6.2e-12 45.4 1.0 0.023 14.8 0.0 5.5 4 2 2 6 6 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 OPL21681.1 - 2.3e-10 40.6 0.0 3.7e-05 23.9 0.0 4.2 3 2 1 4 4 4 1 Tetratricopeptide repeat Coatomer_E PF04733.14 OPL21681.1 - 2.2e-08 33.8 0.1 2.5e-05 23.8 0.0 2.3 1 1 1 2 2 2 2 Coatomer epsilon subunit TPR_9 PF13371.6 OPL21681.1 - 3.8e-07 30.1 0.0 0.006 16.7 0.0 3.6 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 OPL21681.1 - 5.4e-05 22.9 0.1 0.17 11.8 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 OPL21681.1 - 7.3e-05 22.5 0.3 0.15 12.2 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 OPL21681.1 - 0.00044 19.3 0.6 0.0069 15.3 0.1 2.8 1 1 2 3 3 3 1 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 OPL21681.1 - 0.00069 18.9 0.1 2.2 7.4 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 OPL21681.1 - 0.00078 19.1 0.0 0.22 11.2 0.0 2.2 1 1 1 2 2 2 2 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC3 PF12895.7 OPL21681.1 - 0.0037 17.4 0.1 4.4 7.6 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 OPL21681.1 - 0.035 13.8 0.0 0.26 11.0 0.0 2.3 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain DUF1491 PF07372.12 OPL21681.1 - 0.16 12.3 0.0 0.5 10.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) CFTR_R PF14396.6 OPL21682.1 - 0.0034 17.0 0.7 0.0066 16.0 0.7 1.4 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain DUF445 PF04286.12 OPL21682.1 - 0.32 10.7 9.5 0.78 9.5 9.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Chalcone_3 PF16036.5 OPL21682.1 - 0.37 10.9 2.9 0.63 10.1 0.4 2.4 2 2 1 3 3 3 0 Chalcone isomerase-like Phage_prot_Gp6 PF05133.14 OPL21682.1 - 1.4 8.0 12.0 0.02 14.0 4.4 1.7 2 0 0 2 2 2 0 Phage portal protein, SPP1 Gp6-like DUF1640 PF07798.11 OPL21682.1 - 8.4 6.4 12.2 4.9 7.2 2.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1640) DUF4834 PF16118.5 OPL21683.1 - 0.12 13.3 0.1 0.12 13.3 0.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Peptidase_S49_N PF08496.10 OPL21683.1 - 0.18 11.8 0.0 0.25 11.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Gly-zipper_YMGG PF13441.6 OPL21683.1 - 0.35 10.7 6.1 0.58 9.9 6.1 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 OPL21683.1 - 0.75 9.8 6.8 1.7 8.7 6.8 1.5 1 1 0 1 1 1 0 Glycine zipper Roc PF08477.13 OPL21684.1 - 2.2e-14 53.7 0.1 1.7e-07 31.5 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL21684.1 - 4.6e-05 23.1 0.1 0.12 11.9 0.0 2.3 2 0 0 2 2 2 2 Ras family Pox_A32 PF04665.12 OPL21684.1 - 8e-05 22.2 0.5 0.00016 21.2 0.1 1.7 2 0 0 2 2 2 1 Poxvirus A32 protein G-alpha PF00503.20 OPL21684.1 - 0.00071 18.8 0.2 0.00092 18.5 0.2 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 OPL21684.1 - 0.00078 18.9 0.0 0.0016 17.9 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.23 OPL21684.1 - 0.0031 17.6 0.2 0.005 16.9 0.2 1.6 1 1 0 1 1 1 1 Dynamin family ABC_tran PF00005.27 OPL21684.1 - 0.0042 17.6 1.9 0.025 15.1 1.9 2.0 1 1 0 1 1 1 1 ABC transporter AAA_24 PF13479.6 OPL21684.1 - 0.01 15.6 0.1 0.03 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 OPL21684.1 - 0.012 15.8 0.1 0.018 15.2 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 OPL21684.1 - 0.015 15.7 0.2 0.036 14.4 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 OPL21684.1 - 0.016 15.3 1.0 0.042 13.9 1.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 OPL21684.1 - 0.031 14.2 0.4 0.052 13.5 0.4 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 OPL21684.1 - 0.033 14.1 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain SRPRB PF09439.10 OPL21684.1 - 0.049 13.1 0.1 0.12 11.8 0.1 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 OPL21684.1 - 0.085 13.1 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 OPL21684.1 - 0.09 11.9 1.1 0.14 11.3 0.4 1.6 1 1 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Gtr1_RagA PF04670.12 OPL21684.1 - 0.092 12.1 0.3 2.9 7.2 0.0 2.9 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region MobB PF03205.14 OPL21684.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF2791 PF10923.8 OPL21684.1 - 0.15 10.9 0.1 0.37 9.6 0.0 1.6 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) Hormone_recep PF00104.30 OPL21685.1 - 7.4e-16 58.3 1.2 7.4e-16 58.3 1.2 2.1 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 OPL21685.1 - 6.7e-10 39.3 3.9 1.3e-09 38.4 3.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) DUF4806 PF16064.5 OPL21685.1 - 0.043 14.1 0.4 0.043 14.1 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4806) Y_Y_Y PF07495.13 OPL21686.1 - 0.028 14.4 0.1 45 4.1 0.0 3.9 4 0 0 4 4 4 0 Y_Y_Y domain Arfaptin PF06456.13 OPL21687.1 - 0.00064 19.4 0.1 0.0011 18.6 0.1 1.3 1 0 0 1 1 1 1 Arfaptin-like domain HeLo PF14479.6 OPL21687.1 - 0.011 15.6 0.9 0.021 14.7 0.9 1.4 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF4495 PF14906.6 OPL21688.1 - 2.9e-13 49.6 0.9 5.1e-13 48.8 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4495) TetR_C_20 PF17925.1 OPL21688.1 - 0.13 12.6 0.0 38 4.6 0.0 3.1 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain EF-hand_1 PF00036.32 OPL21689.1 - 1.5e-15 55.5 5.0 6e-06 25.4 0.2 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 OPL21689.1 - 1.3e-14 54.4 5.6 3e-13 50.0 1.7 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 OPL21689.1 - 6.8e-13 47.4 0.9 7.5e-05 22.4 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 OPL21689.1 - 6.3e-10 38.1 6.2 1.6e-05 24.1 0.2 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 OPL21689.1 - 6.4e-09 35.5 4.7 3e-05 23.8 0.6 3.1 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_4 PF12763.7 OPL21689.1 - 0.00015 21.7 3.6 0.088 12.8 0.2 2.8 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 OPL21689.1 - 0.002 18.4 0.0 0.13 12.6 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 OPL21689.1 - 0.018 15.3 0.1 0.37 11.1 0.0 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_C97 PF05903.14 OPL21690.1 - 0.014 15.3 0.5 0.018 14.9 0.5 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain UIM PF02809.20 OPL21692.1 - 0.00037 20.2 1.8 0.00037 20.2 1.8 5.1 5 0 0 5 5 5 4 Ubiquitin interaction motif PUA_2 PF14306.6 OPL21693.1 - 1.1e-47 161.7 0.0 3e-47 160.2 0.0 1.7 2 0 0 2 2 2 1 PUA-like domain ATP-sulfurylase PF01747.17 OPL21693.1 - 7.9e-47 159.5 0.0 1.1e-33 116.5 0.0 2.2 1 1 1 2 2 2 2 ATP-sulfurylase APS_kinase PF01583.20 OPL21693.1 - 9.1e-25 87.4 0.0 1.4e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase COMM_domain PF07258.14 OPL21694.1 - 2.6e-16 59.5 0.3 7.1e-16 58.1 0.3 1.8 1 0 0 1 1 1 1 COMM domain EF-hand_1 PF00036.32 OPL21695.1 - 2.2e-06 26.8 0.1 0.02 14.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 OPL21695.1 - 0.00014 21.5 0.0 0.41 10.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 OPL21695.1 - 0.0064 16.9 0.0 0.066 13.7 0.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair Kringle PF00051.18 OPL21696.1 - 1.1e-42 144.3 24.1 3.6e-22 78.5 8.7 2.2 2 0 0 2 2 2 2 Kringle domain Tubulin PF00091.25 OPL21697.1 - 3.4e-30 105.7 0.0 4.2e-30 105.4 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Macro PF01661.21 OPL21699.1 - 9.9e-20 70.8 0.2 9.2e-08 32.2 0.0 3.3 2 1 0 2 2 2 2 Macro domain Coagulin PF02035.15 OPL21699.1 - 0.071 13.0 0.0 0.35 10.7 0.0 2.0 2 0 0 2 2 2 0 Coagulin Glyco_hyd_65N_2 PF14498.6 OPL21699.1 - 0.11 12.4 0.0 0.29 11.0 0.1 1.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, N-terminal domain SRCR PF00530.18 OPL21700.1 - 7.5e-05 23.2 0.8 7.5e-05 23.2 0.8 2.2 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain SKG6 PF08693.10 OPL21700.1 - 0.00012 21.4 5.7 0.00028 20.2 5.7 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 OPL21700.1 - 0.0069 16.2 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF3139 PF11337.8 OPL21700.1 - 0.074 13.7 0.2 0.28 11.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) ORC3_N PF07034.11 OPL21703.1 - 0.017 14.3 0.2 0.02 14.0 0.2 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus zf-RING_11 PF17123.5 OPL21704.1 - 0.00045 19.9 1.0 0.00094 18.9 1.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 OPL21704.1 - 0.0039 17.0 1.1 0.0039 17.0 1.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL21704.1 - 0.071 13.5 1.9 0.071 13.5 1.9 2.0 2 0 0 2 2 2 0 Ring finger domain BK_channel_a PF03493.18 OPL21705.1 - 2.3e-18 66.2 0.4 1.4e-13 50.8 0.0 3.3 2 1 1 3 3 3 2 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 OPL21705.1 - 2e-13 50.1 4.9 4.5e-13 49.0 4.9 1.6 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 OPL21705.1 - 0.0005 19.4 6.8 0.0005 19.4 6.8 1.6 1 1 1 2 2 2 1 Ion transport protein Peptidase_C14 PF00656.22 OPL21707.1 - 1.5e-07 31.6 0.5 1.3e-06 28.5 0.5 2.1 1 1 0 1 1 1 1 Caspase domain SIL1 PF16782.5 OPL21707.1 - 0.0048 16.2 0.1 0.01 15.1 0.1 1.5 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 Coagulase PF08764.10 OPL21707.1 - 0.015 15.5 0.8 0.03 14.5 0.8 1.4 1 0 0 1 1 1 0 Staphylococcus aureus coagulase GerD PF17898.1 OPL21707.1 - 0.12 12.3 0.9 18 5.3 0.0 3.1 3 0 0 3 3 3 0 Spore germination GerD central core domain EF-hand_1 PF00036.32 OPL21708.1 - 2e-13 48.9 10.5 7e-06 25.2 1.8 3.7 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 OPL21708.1 - 4.6e-11 41.7 1.8 0.00013 21.3 0.9 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 OPL21708.1 - 4.5e-10 38.6 9.9 0.0007 19.3 0.3 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 OPL21708.1 - 4.3e-09 36.7 8.1 0.00011 22.5 4.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 OPL21708.1 - 1.9e-06 27.6 8.2 0.013 15.4 0.4 3.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 OPL21708.1 - 0.0092 16.3 0.0 3.7 7.9 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_10 PF14788.6 OPL21708.1 - 0.061 13.2 0.5 0.061 13.2 0.5 2.7 3 0 0 3 3 3 0 EF hand EF-hand_4 PF12763.7 OPL21708.1 - 0.08 12.9 1.3 1.4 8.9 0.2 2.3 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand BIR PF00653.21 OPL21709.1 - 5.6e-36 123.0 5.3 9.4e-21 74.3 2.3 3.3 4 0 0 4 4 4 2 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 OPL21709.1 - 6.5e-13 48.3 7.2 6.5e-13 48.3 7.2 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL21709.1 - 0.00037 20.3 7.9 0.00037 20.3 7.9 2.6 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 OPL21709.1 - 0.0011 18.8 8.7 0.003 17.5 7.0 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 OPL21709.1 - 0.0015 18.4 5.7 0.0015 18.4 5.7 3.1 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL21709.1 - 0.007 16.7 9.5 0.007 16.7 9.5 3.2 3 0 0 3 3 3 1 Ring finger domain Wtap PF17098.5 OPL21710.1 - 0.0019 18.1 11.2 0.015 15.3 7.9 2.1 1 1 1 2 2 2 2 WTAP/Mum2p family Saw1 PF11561.8 OPL21710.1 - 0.021 14.3 3.8 0.028 14.0 3.8 1.2 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Peptidase_S49_N PF08496.10 OPL21710.1 - 0.35 10.9 7.5 0.65 10.1 7.5 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Dicty_REP PF05086.12 OPL21710.1 - 0.64 7.9 6.8 0.85 7.5 6.5 1.3 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein Mgr1 PF08602.10 OPL21710.1 - 1.3 7.8 5.9 1.7 7.4 5.9 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit PH PF00169.29 OPL21711.1 - 2.1e-10 41.1 0.3 2.8e-10 40.6 0.3 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 OPL21711.1 - 0.0001 22.7 1.6 0.00067 20.1 1.6 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 OPL21711.1 - 0.0017 18.7 0.3 0.011 16.1 0.3 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain ABA_GPCR PF12430.8 OPL21711.1 - 0.067 12.9 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor TraC_F_IV PF11130.8 OPL21711.1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer UPF0556 PF10572.9 OPL21712.1 - 0.067 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0556 COR PF16095.5 OPL21713.1 - 6.3e-22 78.3 3.0 1.5e-21 77.2 0.6 2.2 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain HEPN_DZIP3 PF18738.1 OPL21713.1 - 1.5e-05 24.8 0.0 3.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN DUF4422 PF14393.6 OPL21713.1 - 0.025 14.4 1.3 0.15 11.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4422) NKWYS PF10364.9 OPL21713.1 - 0.036 14.2 0.7 0.15 12.2 0.7 2.1 1 0 0 1 1 1 0 Putative capsular polysaccharide synthesis protein DUF4296 PF14129.6 OPL21713.1 - 0.096 13.3 0.6 2.4 8.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) SSPI PF14098.6 OPL21714.1 - 0.0042 17.2 0.1 0.02 15.0 0.1 2.2 1 0 0 1 1 1 1 Small, acid-soluble spore protein I CLP1_P PF16575.5 OPL21714.1 - 0.027 14.3 1.2 0.078 12.8 0.3 2.0 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Androgen_recep PF02166.16 OPL21715.1 - 0.72 8.6 8.3 0.96 8.2 8.3 1.2 1 0 0 1 1 1 0 Androgen receptor ARS2 PF04959.13 OPL21715.1 - 0.95 9.8 6.2 2.7 8.3 0.2 2.1 2 0 0 2 2 2 0 Arsenite-resistance protein 2 RNase_HII PF01351.18 OPL21716.1 - 4.3 7.1 8.0 0.97 9.2 4.8 1.5 2 0 0 2 2 2 0 Ribonuclease HII PcfK PF14058.6 OPL21717.1 - 0.00065 20.0 3.5 0.0011 19.2 3.5 1.3 1 0 0 1 1 1 1 PcfK-like protein Cid2 PF09774.9 OPL21717.1 - 0.0093 16.4 3.6 0.014 15.8 3.6 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Peptidase_S49_N PF08496.10 OPL21717.1 - 0.071 13.2 3.9 0.1 12.6 3.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3464 PF11947.8 OPL21717.1 - 2 8.1 4.5 3.4 7.4 4.5 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 FAM176 PF14851.6 OPL21717.1 - 2.1 8.0 7.3 0.21 11.2 2.8 1.6 2 0 0 2 2 2 0 FAM176 family Cation_efflux PF01545.21 OPL21718.1 - 0.058 13.1 0.6 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 Cation efflux family zf-3CxxC_2 PF17180.4 OPL21719.1 - 0.0029 18.3 0.2 0.0038 17.9 0.2 1.2 1 0 0 1 1 1 1 Zinc-binding domain Laminin_EGF PF00053.24 OPL21719.1 - 0.099 12.8 4.1 2.9 8.1 0.2 2.3 1 1 1 2 2 2 0 Laminin EGF domain Myosin_head PF00063.21 OPL21722.1 - 4.7e-72 243.2 0.1 5.5e-72 243.0 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 OPL21722.1 - 0.00037 20.8 0.1 0.0033 17.7 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 OPL21722.1 - 0.014 15.8 0.0 0.022 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 OPL21722.1 - 0.018 15.4 0.1 0.04 14.3 0.1 1.5 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 OPL21722.1 - 0.026 14.5 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 OPL21722.1 - 0.053 13.3 0.1 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_6 PF12774.7 OPL21722.1 - 0.055 12.4 0.1 0.63 9.0 0.0 2.3 3 0 0 3 3 3 0 Hydrolytic ATP binding site of dynein motor region Lipid_bd PF12888.7 OPL21723.1 - 0.11 12.9 0.1 1.3 9.5 0.0 2.1 2 0 0 2 2 2 0 Lipid-binding putative hydrolase Plasmod_Pvs28 PF06247.11 OPL21723.1 - 0.98 9.8 11.4 0.14 12.4 3.9 2.7 3 0 0 3 3 3 0 Pvs28 EGF domain EGF_2 PF07974.13 OPL21723.1 - 1.6 9.2 9.1 5.8 7.4 9.1 2.0 1 0 0 1 1 1 0 EGF-like domain DUF4064 PF13273.6 OPL21725.1 - 0.021 15.1 0.3 0.021 15.1 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) SRCR PF00530.18 OPL21726.1 - 1.7e-09 38.1 0.1 3.4e-09 37.1 0.1 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.18 OPL21726.1 - 1.3e-05 25.3 1.3 2.4e-05 24.4 1.3 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Mucin PF01456.17 OPL21726.1 - 0.023 14.7 4.7 0.023 14.7 4.7 1.5 2 0 0 2 2 2 0 Mucin-like glycoprotein 7tm_1 PF00001.21 OPL21727.1 - 2e-11 43.7 6.1 2.6e-11 43.4 6.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 OPL21727.1 - 2.6e-05 23.7 11.5 5.1e-05 22.7 6.2 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw DUF898 PF05987.13 OPL21727.1 - 0.002 17.2 0.5 0.0026 16.9 0.5 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) OAD_gamma PF04277.13 OPL21727.1 - 0.39 11.3 0.1 0.39 11.3 0.1 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Glycophorin_A PF01102.18 OPL21727.1 - 0.58 10.4 6.7 0.52 10.6 0.5 2.7 1 1 2 3 3 3 0 Glycophorin A Oxidored_q3 PF00499.20 OPL21727.1 - 1.6 8.4 9.1 52 3.5 9.1 2.3 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF2304 PF10066.9 OPL21727.1 - 1.9 8.7 9.6 0.81 9.9 2.3 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) DED PF01335.21 OPL21728.1 - 0.00085 19.6 0.3 0.00085 19.6 0.3 2.1 2 1 0 2 2 2 1 Death effector domain RFX5_DNA_bdg PF14621.6 OPL21728.1 - 0.032 14.0 0.7 0.24 11.2 0.6 1.9 2 0 0 2 2 2 0 RFX5 DNA-binding domain WD40 PF00400.32 OPL21730.1 - 1.4e-05 25.8 3.0 0.018 15.9 0.1 4.3 3 1 0 3 3 3 2 WD domain, G-beta repeat EF-hand_1 PF00036.32 OPL21731.1 - 7.6e-27 90.8 0.6 1.1e-06 27.8 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 OPL21731.1 - 1.7e-23 82.9 2.4 9.5e-12 45.2 0.0 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 OPL21731.1 - 6e-20 69.8 1.6 0.00024 20.4 0.0 4.5 3 1 2 5 5 5 4 EF hand EF-hand_6 PF13405.6 OPL21731.1 - 4.7e-18 63.5 0.1 0.00069 19.4 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 OPL21731.1 - 9.9e-16 57.3 5.6 5.5e-07 29.3 0.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 OPL21731.1 - 8.8e-06 26.0 0.0 0.001 19.4 0.0 2.5 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 OPL21731.1 - 5.7e-05 23.2 6.3 0.2 11.9 0.7 3.6 1 1 3 4 4 4 4 Dockerin type I domain EF-hand_9 PF14658.6 OPL21731.1 - 0.0066 16.7 0.0 2.3 8.6 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 OPL21731.1 - 0.0079 16.1 0.6 0.046 13.7 0.2 2.2 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Sigma54_CBD PF04963.13 OPL21731.1 - 0.044 13.6 0.1 0.087 12.7 0.1 1.5 1 1 0 1 1 1 0 Sigma-54 factor, core binding domain Excalibur PF05901.11 OPL21731.1 - 2.2 9.0 6.6 61 4.3 0.1 3.9 4 0 0 4 4 4 0 Excalibur calcium-binding domain V-set PF07686.17 OPL21732.1 - 1e-18 67.5 1.3 1.1e-09 38.4 0.4 2.1 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 OPL21732.1 - 8.6e-14 51.9 1.4 1.9e-08 34.7 1.5 2.5 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL21732.1 - 4.5e-11 42.8 3.6 3.1e-08 33.7 1.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL21732.1 - 1.5e-08 34.6 0.0 9.8e-05 22.4 0.1 3.1 2 2 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL21732.1 - 0.00022 21.5 8.1 0.00082 19.7 3.8 3.3 2 2 0 2 2 2 1 Immunoglobulin domain Ig_6 PF18452.1 OPL21732.1 - 0.0028 17.2 0.0 0.23 11.1 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Cass2 PF14526.6 OPL21732.1 - 0.082 13.1 0.2 0.4 10.8 0.1 2.0 1 1 1 2 2 2 0 Integron-associated effector binding protein Adeno_E3_CR1 PF02440.15 OPL21732.1 - 0.094 12.5 3.2 9.8 6.0 0.3 3.1 2 2 0 2 2 2 0 Adenovirus E3 region protein CR1 Ig_4 PF16680.5 OPL21732.1 - 0.1 12.9 0.9 28 5.1 0.0 2.9 2 1 1 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 OPL21732.1 - 0.16 12.1 0.2 7 6.8 0.0 2.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 OPL21732.1 - 0.3 11.5 1.6 23 5.4 0.1 3.3 3 1 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain MT PF12777.7 OPL21733.1 - 5.1e-181 601.2 11.3 7.3e-181 600.7 11.3 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.7 OPL21733.1 - 1.6e-97 325.9 0.0 2.8e-97 325.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_lid_1 PF17857.1 OPL21733.1 - 1.9e-38 130.7 10.5 4.3e-37 126.3 4.5 3.5 2 1 0 2 2 2 1 AAA+ lid domain AAA_9 PF12781.7 OPL21733.1 - 6.2e-35 120.3 0.0 6.2e-35 120.3 0.0 2.8 3 1 0 3 3 3 1 ATP-binding dynein motor region Spc7 PF08317.11 OPL21733.1 - 0.018 13.9 25.5 0.038 12.9 3.3 2.7 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 OPL21733.1 - 0.035 13.4 16.6 0.37 10.1 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ERM PF00769.19 OPL21733.1 - 0.042 13.7 20.7 0.089 12.6 6.6 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family zf-C4H2 PF10146.9 OPL21733.1 - 0.055 13.8 4.7 8.6 6.6 3.7 2.4 2 0 0 2 2 2 0 Zinc finger-containing protein UPF0242 PF06785.11 OPL21733.1 - 0.13 12.3 0.1 0.13 12.3 0.1 2.8 2 1 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus Fez1 PF06818.15 OPL21733.1 - 0.46 10.9 17.5 0.22 12.0 0.9 2.5 2 0 0 2 2 2 0 Fez1 Baculo_PEP_C PF04513.12 OPL21733.1 - 1.2 9.1 14.5 9 6.3 0.8 4.5 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 OPL21733.1 - 1.4 9.4 12.1 17 5.9 2.0 4.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein ADIP PF11559.8 OPL21733.1 - 3.9 7.5 24.5 3.2 7.8 3.5 2.7 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3584 PF12128.8 OPL21733.1 - 6.3 4.2 19.2 0.34 8.4 6.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) DUF724 PF05266.14 OPL21733.1 - 8.4 6.2 19.5 0.88 9.4 1.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 OPL21733.1 - 8.9 4.1 8.6 7.5 4.3 4.8 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Sec3_C PF09763.9 OPL21734.1 - 3e-45 154.9 1.3 3.3e-45 154.7 1.3 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 TPR_6 PF13174.6 OPL21734.1 - 0.16 12.6 0.1 32 5.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat UTP25 PF06862.12 OPL21735.1 - 6.2e-84 282.5 15.1 1.2e-41 143.0 2.0 5.0 1 1 3 4 4 4 4 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 OPL21735.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase EKR PF10371.9 OPL21736.1 - 0.087 12.6 1.0 9.3 6.1 0.0 3.8 1 1 2 4 4 4 0 Domain of unknown function Pkinase PF00069.25 OPL21737.1 - 0.0014 18.0 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HEPN_DZIP3 PF18738.1 OPL21738.1 - 2.6e-08 33.7 0.9 7.5e-07 29.0 0.9 2.5 1 1 0 1 1 1 1 DZIP3/ hRUL138-like HEPN CAMP_factor PF07373.11 OPL21738.1 - 0.0046 16.6 0.3 0.0066 16.1 0.3 1.2 1 0 0 1 1 1 1 CAMP factor (Cfa) FlaC_arch PF05377.11 OPL21738.1 - 0.0099 16.2 4.8 0.18 12.2 1.0 2.4 1 1 1 2 2 2 1 Flagella accessory protein C (FlaC) SKA2 PF16740.5 OPL21738.1 - 0.02 14.7 1.4 0.045 13.5 1.3 1.7 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 NPV_P10 PF05531.12 OPL21738.1 - 0.038 14.4 5.4 0.16 12.4 3.3 2.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 OPL21738.1 - 0.093 12.8 3.3 0.36 10.9 3.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Sec2p PF06428.11 OPL21738.1 - 0.13 12.3 1.1 0.69 9.9 0.3 2.3 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Laminin_II PF06009.12 OPL21738.1 - 0.15 12.1 2.7 0.62 10.1 2.7 1.9 1 1 0 1 1 1 0 Laminin Domain II DUF948 PF06103.11 OPL21738.1 - 0.2 11.9 5.6 0.56 10.5 5.6 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) COG2 PF06148.11 OPL21738.1 - 0.53 10.4 3.0 13 5.8 0.6 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DASH_Duo1 PF08651.10 OPL21738.1 - 3.1 7.6 5.8 4.5 7.1 0.9 2.6 2 1 1 3 3 3 0 DASH complex subunit Duo1 BIR PF00653.21 OPL21739.1 - 5.6e-35 119.8 5.5 5.1e-20 71.9 0.1 3.6 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain HYR PF02494.16 OPL21740.1 - 2.8e-27 94.9 2.3 3.2e-19 69.0 0.2 2.4 2 0 0 2 2 2 2 HYR domain VWA PF00092.28 OPL21740.1 - 1.7e-14 54.4 0.0 2.4e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Sushi PF00084.20 OPL21740.1 - 2.5e-13 50.4 11.8 3.3e-09 37.2 1.3 3.5 3 1 1 4 4 4 2 Sushi repeat (SCR repeat) IL17R_D_N PF16742.5 OPL21742.1 - 0.02 15.0 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D DUF2682 PF10909.8 OPL21742.1 - 0.057 13.9 0.2 0.12 12.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2682) UvrD_C_2 PF13538.6 OPL21743.1 - 2.3e-06 27.4 0.0 0.029 14.2 0.0 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C PF13361.6 OPL21743.1 - 3.7e-05 23.3 1.8 0.0025 17.3 0.0 2.8 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain Sigma54_activ_2 PF14532.6 OPL21743.1 - 0.093 12.9 0.0 4.9 7.3 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_22 PF13401.6 OPL21743.1 - 0.1 12.9 0.1 1.9 8.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 OPL21743.1 - 0.12 12.1 0.1 2.9 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Transposase_21 PF02992.14 OPL21745.1 - 0.00065 19.0 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 Transposase family tnp2 zf-C2H2_4 PF13894.6 OPL21745.1 - 0.36 11.8 0.3 0.36 11.8 0.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Crust_neurohorm PF01147.17 OPL21745.1 - 0.57 10.0 4.6 1.4 8.8 2.2 2.4 2 0 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family DNA_pol_B_N PF18094.1 OPL21746.1 - 0.072 13.6 0.3 0.18 12.4 0.0 1.8 2 1 0 2 2 2 0 DNA polymerase beta N-terminal domain fn3 PF00041.21 OPL21747.1 - 6.4e-49 164.2 13.5 6e-14 52.2 0.3 4.5 4 0 0 4 4 4 4 Fibronectin type III domain Neogenin_C PF06583.12 OPL21747.1 - 1.7e-14 54.4 4.6 2.7e-14 53.7 4.6 1.3 1 0 0 1 1 1 1 Neogenin C-terminus Pur_ac_phosph_N PF16656.5 OPL21747.1 - 1.7e-10 41.3 10.0 0.0046 17.5 0.2 5.3 4 2 0 4 4 4 3 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 OPL21747.1 - 1e-07 32.2 0.1 0.22 11.9 0.0 4.3 4 0 0 4 4 4 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 OPL21747.1 - 1.1e-05 25.7 0.5 6.1 7.2 0.1 4.6 4 1 0 4 4 4 2 Interferon-alpha/beta receptor, fibronectin type III EphA2_TM PF14575.6 OPL21747.1 - 0.0013 19.5 0.0 0.0041 18.0 0.0 1.8 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 OPL21747.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family GPI-anchored PF10342.9 OPL21747.1 - 0.031 15.0 5.0 0.052 14.3 0.1 3.5 4 1 0 4 4 4 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF1410 PF07198.11 OPL21747.1 - 0.55 10.8 4.4 31 5.1 0.2 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1410) Insulin_TMD PF17870.1 OPL21747.1 - 1.1 9.4 6.9 2.6 8.2 6.9 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment HSP70 PF00012.20 OPL21748.1 - 1.4e-06 26.8 0.0 4.5e-06 25.2 0.0 1.8 1 1 0 1 1 1 1 Hsp70 protein DDR PF08841.10 OPL21748.1 - 0.18 10.8 0.0 0.47 9.4 0.0 1.7 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain BTB PF00651.31 OPL21749.1 - 2.2e-27 95.5 0.4 7.2e-26 90.6 0.0 2.5 1 1 1 2 2 2 1 BTB/POZ domain PHR PF08005.12 OPL21749.1 - 3.3e-07 31.1 0.8 7.7e-07 29.9 0.1 2.0 2 0 0 2 2 2 1 PHR domain BACK PF07707.15 OPL21749.1 - 3.1e-06 27.2 1.9 6.4e-06 26.2 0.6 2.2 2 1 0 2 2 2 1 BTB And C-terminal Kelch SAM_PNT PF02198.16 OPL21749.1 - 0.12 12.3 0.2 0.41 10.7 0.0 1.9 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain RICTOR_M PF14666.6 OPL21750.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain Baculo_11_kDa PF06143.11 OPL21750.1 - 2.6 7.7 5.4 1.4 8.6 0.1 2.3 1 1 0 2 2 2 0 Baculovirus 11 kDa family AAA_16 PF13191.6 OPL21751.1 - 8.9e-05 22.9 0.0 0.00023 21.6 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 OPL21751.1 - 0.00042 20.4 0.0 0.00079 19.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 OPL21751.1 - 0.0012 19.3 0.3 0.0018 18.8 0.3 1.5 1 1 0 1 1 1 1 ABC transporter Septin PF00735.18 OPL21751.1 - 0.0013 18.0 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 Septin DUF815 PF05673.13 OPL21751.1 - 0.0036 16.5 0.0 0.006 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IIGP PF05049.13 OPL21751.1 - 0.006 15.7 0.0 0.0092 15.1 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_15 PF13175.6 OPL21751.1 - 0.012 15.3 0.8 0.017 14.9 0.8 1.2 1 0 0 1 1 1 0 AAA ATPase domain KAP_NTPase PF07693.14 OPL21751.1 - 0.015 14.6 0.0 0.017 14.3 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain RsgA_GTPase PF03193.16 OPL21751.1 - 0.019 14.9 0.1 0.036 14.0 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase SMC_N PF02463.19 OPL21751.1 - 0.038 13.4 0.1 0.059 12.8 0.1 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_7 PF12775.7 OPL21751.1 - 0.055 13.0 0.0 0.16 11.4 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region PRK PF00485.18 OPL21751.1 - 0.067 12.9 0.1 0.088 12.5 0.1 1.4 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family FtsK_SpoIIIE PF01580.18 OPL21751.1 - 0.067 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 OPL21751.1 - 0.073 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Dynamin_N PF00350.23 OPL21751.1 - 0.077 13.1 0.5 0.24 11.4 0.3 2.0 2 0 0 2 2 2 0 Dynamin family AAA_28 PF13521.6 OPL21751.1 - 0.078 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 OPL21751.1 - 0.08 13.2 0.0 0.14 12.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 OPL21751.1 - 0.097 11.8 0.1 0.68 9.1 0.1 2.1 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 OPL21751.1 - 0.11 12.9 0.1 0.21 12.0 0.1 1.7 1 1 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 OPL21751.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain zf-B_box PF00643.24 OPL21752.1 - 1.4e-13 50.8 17.7 1.3e-08 34.8 4.8 2.3 2 0 0 2 2 2 2 B-box zinc finger DUF4404 PF14357.6 OPL21752.1 - 0.08 13.6 8.1 0.19 12.4 0.8 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) Tox-HDC PF15656.6 OPL21752.1 - 0.098 12.8 0.3 0.22 11.7 0.3 1.6 1 0 0 1 1 1 0 Toxin with a H, D/N and C signature Kri1 PF05178.12 OPL21752.1 - 2.8 8.5 10.8 5.9 7.5 8.0 2.7 2 1 0 2 2 2 0 KRI1-like family CRR7 PF12095.8 OPL21752.1 - 3.9 8.0 7.5 2.9 8.4 0.6 3.2 1 1 2 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 Forkhead PF00250.18 OPL21754.1 - 4.8e-42 142.1 0.1 9.4e-42 141.2 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain ATG_C PF09333.11 OPL21754.1 - 0.066 13.6 1.6 0.12 12.7 0.4 2.1 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain Linker_histone PF00538.19 OPL21754.1 - 0.11 12.8 0.0 0.35 11.3 0.0 1.8 1 0 0 1 1 1 0 linker histone H1 and H5 family fn3 PF00041.21 OPL21755.1 - 7e-06 26.3 0.8 0.51 10.7 0.1 3.3 3 0 0 3 3 3 3 Fibronectin type III domain PET117 PF15786.5 OPL21757.1 - 0.084 13.2 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial PSI PF01437.25 OPL21758.1 - 0.018 15.6 3.0 0.024 15.2 3.0 1.2 1 0 0 1 1 1 0 Plexin repeat MTBP_C PF14920.6 OPL21759.1 - 1.8e-12 47.6 7.9 1.8e-12 47.6 7.9 1.7 1 1 1 2 2 2 1 MDM2-binding Peptidase_C2 PF00648.21 OPL21761.1 - 1.6e-26 93.0 0.0 2.3e-26 92.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 OPL21761.1 - 4.1e-14 53.0 0.0 8.9e-14 51.9 0.0 1.6 2 0 0 2 2 2 1 Calpain large subunit, domain III DHBP_synthase PF00926.19 OPL21761.1 - 0.17 11.4 0.0 0.23 11.0 0.0 1.1 1 0 0 1 1 1 0 3,4-dihydroxy-2-butanone 4-phosphate synthase HSP70 PF00012.20 OPL21762.1 - 1.3e-12 46.7 0.6 1.8e-12 46.3 0.6 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL21762.1 - 0.0031 16.4 0.3 0.0047 15.8 0.3 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Vinculin PF01044.19 OPL21763.1 - 8.1e-143 477.8 13.2 1.4e-82 278.5 0.9 2.0 1 1 1 2 2 2 2 Vinculin family GARP PF16731.5 OPL21763.1 - 0.011 15.4 7.7 0.55 9.9 0.3 3.3 4 0 0 4 4 4 0 Glutamic acid/alanine-rich protein of Trypanosoma SLX9 PF15341.6 OPL21763.1 - 0.074 13.4 0.6 0.16 12.4 0.6 1.5 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Calici_coat PF00915.20 OPL21763.1 - 0.095 11.6 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Calicivirus coat protein DUF3140 PF11338.8 OPL21763.1 - 0.1 13.0 0.3 0.68 10.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3140) Hormone_1 PF00103.20 OPL21763.1 - 0.15 11.8 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Somatotropin hormone family Fes1 PF08609.10 OPL21763.1 - 0.55 11.1 3.4 2 9.4 0.2 3.2 2 1 1 4 4 4 0 Nucleotide exchange factor Fes1 I_LWEQ PF01608.17 OPL21763.1 - 1.8 8.8 8.4 0.93 9.7 0.5 3.4 3 1 1 4 4 4 0 I/LWEQ domain C1q PF00386.21 OPL21765.1 - 8.7e-20 71.2 0.1 1.5e-19 70.5 0.1 1.4 1 0 0 1 1 1 1 C1q domain DUF2729 PF10870.8 OPL21765.1 - 0.099 12.5 0.5 0.25 11.2 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2729) Pox_A_type_inc PF04508.12 OPL21765.1 - 0.13 12.2 0.2 0.26 11.2 0.2 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat CPSase_L_D3 PF02787.19 OPL21766.1 - 0.39 11.1 6.7 0.4 11.0 1.3 3.2 3 1 0 3 3 3 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain TIMP PF00965.17 OPL21767.1 - 7.3e-13 48.7 0.1 8.3e-13 48.5 0.1 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 OPL21767.1 - 2.5e-05 24.0 0.0 4.1e-05 23.3 0.0 1.4 1 1 0 1 1 1 1 UNC-6/NTR/C345C module Fibrinogen_C PF00147.18 OPL21768.1 - 2.7e-47 161.4 4.3 2.7e-47 161.4 4.3 1.4 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 OPL21768.1 - 0.049 12.9 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain I-set PF07679.16 OPL21769.1 - 3.2e-06 27.1 0.0 4.8e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL21769.1 - 5.2e-05 23.8 0.0 9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 OPL21769.1 - 0.0024 18.0 0.0 0.0038 17.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL21769.1 - 0.0037 17.5 0.0 0.0084 16.4 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 OPL21769.1 - 0.051 13.7 0.1 0.1 12.8 0.1 1.6 1 1 0 1 1 1 0 Immunoglobulin V-set domain EF-hand_1 PF00036.32 OPL21770.1 - 5.5e-16 56.8 0.5 8.5e-09 34.3 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 OPL21770.1 - 2.5e-14 53.4 1.2 3.4e-14 53.0 1.2 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 OPL21770.1 - 3.7e-12 45.1 0.7 4.1e-05 23.2 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 OPL21770.1 - 5e-12 45.5 2.3 2.7e-11 43.2 0.9 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 OPL21770.1 - 1.9e-08 34.5 0.2 2.3e-08 34.3 0.2 1.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 OPL21770.1 - 3.4e-06 26.3 2.2 0.00032 20.1 0.1 2.8 2 1 1 3 3 3 2 EF hand EF-hand_4 PF12763.7 OPL21770.1 - 0.027 14.4 0.5 0.033 14.1 0.5 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Thrombin_light PF09396.10 OPL21770.1 - 0.068 12.9 0.6 0.068 12.9 0.6 1.8 2 0 0 2 2 2 0 Thrombin light chain EF-hand_11 PF08976.11 OPL21770.1 - 0.11 13.3 0.0 0.19 12.6 0.0 1.4 1 1 0 1 1 1 0 EF-hand domain DED PF01335.21 OPL21770.1 - 0.18 12.1 2.1 11 6.5 0.1 2.1 1 1 1 2 2 2 0 Death effector domain DUF3008 PF11450.8 OPL21770.1 - 0.22 11.7 0.0 0.48 10.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) FERM_C PF09380.10 OPL21772.1 - 2.6e-18 66.2 0.1 6.7e-18 64.9 0.1 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 OPL21772.1 - 4.9e-18 65.6 0.3 1.1e-17 64.5 0.3 1.6 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 OPL21772.1 - 2.7e-11 43.2 0.0 7.3e-11 41.9 0.0 1.8 1 0 0 1 1 1 1 FERM N-terminal domain C1q PF00386.21 OPL21774.1 - 2.7e-21 76.1 0.7 3.3e-21 75.8 0.7 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL21774.1 - 0.0048 16.8 0.3 0.0065 16.4 0.3 1.2 1 0 0 1 1 1 1 BclA C-terminal domain PCB_OB PF17092.5 OPL21774.1 - 0.16 12.7 0.0 0.2 12.4 0.0 1.2 1 0 0 1 1 1 0 Penicillin-binding protein OB-like domain dCache_1 PF02743.18 OPL21775.1 - 5.1e-08 33.0 0.0 7.4e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Cache domain dCache_2 PF08269.11 OPL21775.1 - 0.043 13.0 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 Cache domain EphA2_TM PF14575.6 OPL21776.1 - 0.017 16.0 0.2 0.023 15.6 0.2 1.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PgaD PF13994.6 OPL21776.1 - 0.085 12.9 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 PgaD-like protein Cadherin_C_2 PF16492.5 OPL21776.1 - 0.2 12.5 1.0 0.28 12.0 1.0 1.4 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal VIR_N PF15912.5 OPL21777.1 - 0.84 9.2 5.7 1 8.9 5.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal ABC_tran PF00005.27 OPL21778.1 - 3.7e-09 37.2 0.0 4e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 ABC transporter ADAM_spacer1 PF05986.14 OPL21780.1 - 6.7e-18 64.8 0.0 8.1e-18 64.5 0.0 1.1 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 OPL21781.1 - 1.1e-05 25.5 37.0 0.00074 19.7 12.6 4.0 3 2 0 3 3 3 2 Thrombospondin type 1 domain Fungus-induced PF10917.8 OPL21782.1 - 0.22 11.9 0.2 0.22 11.9 0.2 2.3 2 1 0 2 2 2 0 Fungus-induced protein Collagen PF01391.18 OPL21782.1 - 1.1 9.0 44.1 2 8.2 44.1 1.4 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) CARD PF00619.21 OPL21783.1 - 1.9e-15 56.6 0.3 6.8e-15 54.9 0.0 2.1 2 0 0 2 2 2 1 Caspase recruitment domain CARD_2 PF16739.5 OPL21783.1 - 1.7e-05 24.7 0.2 8.5e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 Caspase recruitment domain PhyH PF05721.13 OPL21784.1 - 1.6e-11 44.9 0.1 3.3e-11 43.9 0.1 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TIMP PF00965.17 OPL21785.1 - 0.03 14.1 1.0 0.053 13.3 1.0 1.4 1 1 0 1 1 1 0 Tissue inhibitor of metalloproteinase Toxin_3 PF00537.18 OPL21785.1 - 0.14 12.4 6.0 0.11 12.6 4.2 1.8 2 1 0 2 2 2 0 Scorpion toxin-like domain Defensin_2 PF01097.18 OPL21786.1 - 0.072 13.0 10.1 0.12 12.3 10.1 1.3 1 0 0 1 1 1 0 Arthropod defensin Ank_2 PF12796.7 OPL21858.1 - 3.4e-74 245.5 10.6 4.3e-17 62.5 0.2 5.8 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 OPL21858.1 - 1.4e-46 151.0 1.5 0.00031 20.9 0.0 10.1 10 0 0 10 10 9 9 Ankyrin repeat Ank PF00023.30 OPL21858.1 - 1.1e-45 152.2 1.2 3.4e-05 24.1 0.1 10.1 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 OPL21858.1 - 8.1e-44 147.1 5.6 1.8e-07 31.3 0.1 9.5 2 2 8 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 OPL21858.1 - 6.2e-43 144.6 2.7 1.9e-07 31.4 0.0 7.1 2 2 6 8 8 8 8 Ankyrin repeats (many copies) HEPN_DZIP3 PF18738.1 OPL21858.1 - 2.5e-18 66.2 0.4 8.7e-18 64.4 0.1 2.2 2 0 0 2 2 2 1 DZIP3/ hRUL138-like HEPN RNA_helicase PF00910.22 OPL21858.1 - 0.00016 22.0 0.0 0.00045 20.6 0.0 1.8 1 0 0 1 1 1 1 RNA helicase Rad17 PF03215.15 OPL21858.1 - 0.00019 21.4 0.1 0.00085 19.3 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 OPL21858.1 - 0.00067 19.9 0.1 0.0022 18.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain PhoH PF02562.16 OPL21858.1 - 0.00084 18.9 0.2 0.86 9.0 0.0 3.0 2 1 0 3 3 3 2 PhoH-like protein ATPase_2 PF01637.18 OPL21858.1 - 0.0011 18.9 0.1 0.0051 16.7 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 OPL21858.1 - 0.0012 19.3 0.0 0.0027 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 OPL21858.1 - 0.0032 18.0 0.2 0.017 15.6 0.0 2.4 1 1 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 OPL21858.1 - 0.013 15.3 0.1 0.056 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 OPL21858.1 - 0.019 14.9 0.2 0.16 11.9 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_5 PF07728.14 OPL21858.1 - 0.052 13.5 0.0 0.65 10.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 OPL21858.1 - 0.11 12.3 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 OPL21858.1 - 0.11 11.8 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 OPL21858.1 - 0.11 13.0 0.6 1.8 9.1 0.1 3.0 2 1 0 2 2 2 0 AAA domain Tnp_22_dsRBD PF17490.2 OPL21858.1 - 0.12 12.4 0.2 4.2 7.4 0.0 3.3 3 0 0 3 3 3 0 L1 transposable element dsRBD-like domain Tn7_Tnp_TnsA_C PF08721.11 OPL21858.1 - 0.22 12.2 1.6 1 10.1 0.1 3.0 3 0 0 3 3 2 0 TnsA endonuclease C terminal SMC_N PF02463.19 OPL21858.1 - 0.25 10.8 0.4 2.6 7.4 0.0 2.3 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain C2 PF00168.30 OPL21870.1 - 1e-22 80.3 0.1 8.1e-12 45.3 0.0 2.4 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 OPL21870.1 - 0.032 13.8 0.0 5.2 6.6 0.0 2.4 2 0 0 2 2 2 0 CEP76 C2 domain Roc PF08477.13 OPL21887.1 - 2.3e-05 24.6 0.1 3.1e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL21887.1 - 0.0023 17.6 0.1 0.0027 17.3 0.1 1.2 1 0 0 1 1 1 1 Ras family Vmethyltransf PF01660.17 OPL21887.1 - 0.0067 15.3 0.0 0.0067 15.3 0.0 1.0 1 0 0 1 1 1 1 Viral methyltransferase PduV-EutP PF10662.9 OPL21887.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 OPL21887.1 - 0.012 15.7 0.1 0.018 15.1 0.1 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Arf PF00025.21 OPL21887.1 - 0.013 15.0 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Dynamin_N PF00350.23 OPL21887.1 - 0.019 15.0 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Dynamin family ABC_tran PF00005.27 OPL21887.1 - 0.028 14.9 0.0 0.033 14.7 0.0 1.2 1 0 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.18 OPL21887.1 - 0.029 13.7 0.0 0.04 13.3 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_14 PF13173.6 OPL21887.1 - 0.036 14.1 0.2 0.078 13.0 0.1 1.8 1 1 1 2 2 2 0 AAA domain GTP_EFTU PF00009.27 OPL21887.1 - 0.049 13.2 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 OPL21887.1 - 0.051 13.8 0.0 0.051 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 OPL21887.1 - 0.061 12.7 0.0 0.074 12.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 OPL21887.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.5 1 1 0 1 1 1 0 Bacterial TniB protein Septin PF00735.18 OPL21887.1 - 0.12 11.6 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Septin MobB PF03205.14 OPL21887.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B OTU PF02338.19 OPL21918.1 - 8.5e-10 39.2 0.0 1.7e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 OPL21918.1 - 0.0091 15.5 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase C65 Otubain Herpes_IE68 PF02479.16 OPL21918.1 - 0.026 14.1 0.1 2 8.0 0.0 2.4 2 0 0 2 2 2 0 Herpesvirus immediate early protein SAM_2 PF07647.17 OPL21964.1 - 2.9e-05 24.1 0.1 5.9e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 OPL21964.1 - 0.01 16.3 0.1 0.023 15.1 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) CIDE-N PF02017.15 OPL22014.1 - 8e-30 102.7 0.0 1.6e-29 101.8 0.0 1.5 1 0 0 1 1 1 1 CIDE-N domain DFF-C PF09033.10 OPL22014.1 - 8.5e-16 58.3 0.3 1.4e-15 57.6 0.3 1.3 1 0 0 1 1 1 1 DNA Fragmentation factor 45kDa, C terminal domain KHA PF11834.8 OPL22014.1 - 0.0053 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel ClpB_D2-small PF10431.9 OPL22014.1 - 0.026 14.6 0.9 0.6 10.2 0.3 2.4 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Jag_N PF14804.6 OPL22014.1 - 0.1 13.0 0.2 6.7 7.1 0.1 2.3 2 0 0 2 2 2 0 Jag N-terminus GMC_oxred_N PF00732.19 OPL22018.1 - 2.8e-34 118.9 0.2 2.2e-33 115.9 0.2 1.9 1 1 0 1 1 1 1 GMC oxidoreductase PH PF00169.29 OPL22021.1 - 3.1e-07 30.9 0.0 3.6e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 PH domain MyTH4 PF00784.17 OPL22022.1 - 4.4e-33 114.0 2.2 9.5e-32 109.7 2.2 2.0 1 1 0 1 1 1 1 MyTH4 domain SH3_9 PF14604.6 OPL22034.1 - 1.9e-09 37.2 2.3 5.9e-07 29.3 0.0 3.4 3 1 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.17 OPL22034.1 - 1.3e-06 27.9 1.5 4.1e-05 23.2 0.0 2.6 3 0 0 3 3 3 1 Variant SH3 domain SH3_1 PF00018.28 OPL22034.1 - 0.0022 17.6 4.4 0.45 10.2 0.0 3.0 3 0 0 3 3 3 2 SH3 domain PIEZO PF15917.5 OPL22055.1 - 0.012 15.1 0.0 0.014 14.9 0.0 1.0 1 0 0 1 1 1 0 Piezo TMEM215 PF15746.5 OPL22055.1 - 0.056 12.9 0.1 0.061 12.8 0.1 1.1 1 0 0 1 1 1 0 TMEM215 family IstB_IS21 PF01695.17 OPL22107.1 - 0.0043 16.8 0.0 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 OPL22107.1 - 0.0078 16.6 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain PhoH PF02562.16 OPL22107.1 - 0.0089 15.5 0.1 0.018 14.5 0.0 1.5 2 0 0 2 2 2 1 PhoH-like protein AAA_7 PF12775.7 OPL22107.1 - 0.01 15.4 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 OPL22107.1 - 0.02 14.6 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 OPL22107.1 - 0.024 15.0 0.1 0.066 13.6 0.0 1.8 2 1 0 2 2 2 0 RNA helicase ATPase PF06745.13 OPL22107.1 - 0.026 13.9 0.4 0.073 12.4 0.1 1.9 1 1 1 2 2 2 0 KaiC AAA_22 PF13401.6 OPL22107.1 - 0.027 14.7 0.3 0.11 12.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 OPL22107.1 - 0.029 13.9 0.0 0.049 13.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 OPL22107.1 - 0.033 13.5 0.1 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin KTI12 PF08433.10 OPL22107.1 - 0.034 13.6 0.6 0.2 11.0 0.0 2.1 1 1 1 2 2 2 0 Chromatin associated protein KTI12 AAA_5 PF07728.14 OPL22107.1 - 0.047 13.7 0.0 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 OPL22107.1 - 0.064 13.2 0.2 0.67 9.8 0.0 2.4 3 0 0 3 3 3 0 NTPase AAA_18 PF13238.6 OPL22107.1 - 0.068 13.7 0.1 0.41 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 OPL22107.1 - 0.074 12.2 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) APS_kinase PF01583.20 OPL22107.1 - 0.08 12.8 0.0 0.57 10.1 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_19 PF13245.6 OPL22107.1 - 0.098 13.0 0.1 0.25 11.6 0.0 1.7 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 OPL22107.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.6 OPL22107.1 - 0.11 12.7 0.1 0.27 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 OPL22107.1 - 0.12 11.4 0.0 0.17 10.9 0.0 1.3 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 OPL22107.1 - 0.13 12.7 0.3 0.3 11.5 0.0 1.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 OPL22107.1 - 0.13 12.4 0.0 0.38 10.9 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain YabA PF06156.13 OPL22107.1 - 0.14 12.8 3.6 0.2 12.3 3.6 1.3 1 0 0 1 1 1 0 Initiation control protein YabA Hpr_kinase_C PF07475.12 OPL22107.1 - 0.24 10.9 2.3 1.2 8.6 0.0 2.1 1 1 1 2 2 2 0 HPr Serine kinase C-terminal domain ABC_tran PF00005.27 OPL22107.1 - 1.2 9.6 3.2 2.2 8.8 0.1 2.2 1 1 1 2 2 2 0 ABC transporter Nramp PF01566.18 OPL22169.1 - 1e-13 51.1 0.1 1.4e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein DUF4264 PF14084.6 OPL22201.1 - 0.086 12.5 0.0 0.3 10.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) E1_DerP2_DerF2 PF02221.15 OPL22353.1 - 2.6e-06 27.9 0.0 4.5e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 ML domain RSN1_7TM PF02714.15 OPL22367.1 - 1.7e-20 73.5 10.8 1.7e-20 73.5 10.8 1.8 1 1 1 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate DUF2206 PF09971.9 OPL22367.1 - 0.0064 15.3 2.8 0.0064 15.3 2.8 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2206) Birna_VP3 PF01767.16 OPL22369.1 - 0.069 13.2 0.0 0.077 13.1 0.0 1.0 1 0 0 1 1 1 0 Birnavirus VP3 protein Vinculin PF01044.19 OPL22478.1 - 6.1e-55 187.0 0.5 7.2e-55 186.7 0.5 1.1 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.17 OPL22478.1 - 0.11 12.7 2.7 0.85 9.8 0.4 2.0 2 0 0 2 2 2 0 I/LWEQ domain TelA PF05816.11 OPL22478.1 - 0.44 9.6 3.7 0.3 10.1 0.8 1.9 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) LSDAT_euk PF18139.1 OPL22675.1 - 1.1e-05 24.9 0.1 2.1e-05 24.1 0.1 1.4 1 1 0 1 1 1 1 SLOG in TRPM TctC PF03401.14 OPL22675.1 - 0.044 12.8 0.0 0.06 12.4 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor Plk4_PB1 PF18190.1 OPL23072.1 - 0.066 13.4 0.8 0.089 13.0 0.8 1.1 1 0 0 1 1 1 0 Polo-like Kinase 4 Polo Box 1 M20_dimer PF07687.14 OPL23484.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase dimerisation domain Peptidase_M20 PF01546.28 OPL23484.1 - 0.014 15.1 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 NmrA PF05368.13 OPL23484.1 - 0.13 11.8 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 NmrA-like family Vinculin PF01044.19 OPL23517.1 - 8.6e-154 514.2 17.9 1.4e-136 457.2 15.4 2.7 1 1 1 2 2 2 2 Vinculin family OmpH PF03938.14 OPL23517.1 - 0.00019 21.8 6.9 0.39 11.0 0.2 3.6 3 0 0 3 3 3 3 Outer membrane protein (OmpH-like) Apolipoprotein PF01442.18 OPL23517.1 - 0.0081 16.1 1.8 0.0081 16.1 1.8 2.1 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain EH_Signature PF15611.6 OPL23517.1 - 0.047 13.1 0.2 0.073 12.5 0.2 1.3 1 0 0 1 1 1 0 EH_Signature domain I_LWEQ PF01608.17 OPL23517.1 - 0.097 12.9 2.3 0.42 10.9 0.2 2.8 1 1 0 2 2 2 0 I/LWEQ domain Metal_resist PF13801.6 OPL23517.1 - 0.11 12.7 4.2 0.58 10.4 0.4 2.8 2 0 0 2 2 2 0 Heavy-metal resistance YtxH PF12732.7 OPL23517.1 - 0.18 12.4 0.3 1.3 9.6 0.3 2.5 1 1 0 1 1 1 0 YtxH-like protein DUF1090 PF06476.12 OPL23517.1 - 0.29 11.3 5.6 0.12 12.6 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) DENN PF02141.21 OPL24518.1 - 1.9e-52 177.9 0.0 2.7e-52 177.4 0.0 1.2 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 OPL24518.1 - 4.8e-10 40.1 0.6 1.3e-09 38.7 0.6 1.8 1 0 0 1 1 1 1 uDENN domain Avl9 PF09794.9 OPL24518.1 - 0.00038 19.3 0.2 0.03 13.0 0.2 2.8 1 1 1 2 2 2 1 Transport protein Avl9 SPA PF08616.10 OPL24518.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Stabilization of polarity axis COR PF16095.5 OPL24965.1 - 4.6e-09 36.4 0.1 7.8e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Ank_2 PF12796.7 OPL25171.1 - 2.4e-31 108.1 0.6 1.2e-12 48.2 0.3 3.3 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL25171.1 - 3e-26 91.5 0.7 2.3e-08 34.4 0.1 5.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL25171.1 - 4.8e-22 75.7 0.2 0.0024 18.2 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 OPL25171.1 - 5.5e-22 77.2 2.1 0.0044 17.4 0.0 6.8 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 OPL25171.1 - 1.5e-21 76.2 2.0 1.6e-07 31.4 0.1 5.5 1 1 4 6 6 6 5 Ankyrin repeats (many copies) PEGA PF08308.11 OPL25171.1 - 0.035 14.0 0.0 0.93 9.4 0.0 2.3 2 0 0 2 2 2 0 PEGA domain Pep_M12B_propep PF01562.19 OPL27350.1 - 2.5e-12 47.2 1.2 3.6e-12 46.7 1.0 1.3 1 1 0 1 1 1 1 Reprolysin family propeptide Aldo_ket_red PF00248.21 OPL28211.1 - 2.7e-19 69.5 0.0 4e-12 45.9 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family An_peroxidase PF03098.15 OPL28700.1 - 8e-26 90.7 0.1 9.2e-26 90.5 0.1 1.0 1 0 0 1 1 1 1 Animal haem peroxidase RBD-FIP PF09457.10 OPL28909.1 - 0.061 13.3 1.1 0.14 12.1 1.1 1.6 1 0 0 1 1 1 0 FIP domain DUF4175 PF13779.6 OPL28909.1 - 0.098 10.5 0.9 1 7.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) SKG6 PF08693.10 OPL28935.1 - 0.0034 16.7 4.5 0.0066 15.8 4.5 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.12 OPL28935.1 - 0.014 15.3 0.2 0.028 14.3 0.2 1.6 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor SEA PF01390.20 OPL28935.1 - 0.042 13.9 0.3 0.064 13.4 0.3 1.2 1 0 0 1 1 1 0 SEA domain FOLN PF09289.10 OPL28935.1 - 0.047 13.9 0.7 0.047 13.9 0.7 1.8 2 0 0 2 2 2 0 Follistatin/Osteonectin-like EGF domain MLANA PF14991.6 OPL28935.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A PspB PF06667.12 OPL28935.1 - 0.23 11.6 0.0 0.36 10.9 0.0 1.2 1 0 0 1 1 1 0 Phage shock protein B VWD PF00094.25 OPL29176.1 - 7.9e-14 52.2 0.3 9.2e-14 52.0 0.3 1.0 1 0 0 1 1 1 1 von Willebrand factor type D domain AAA_11 PF13086.6 OPL29395.1 - 1.2e-22 81.0 0.4 1.2e-22 81.0 0.4 1.5 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 OPL29395.1 - 2.9e-20 72.8 0.3 5.2e-20 71.9 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 OPL29395.1 - 5e-05 23.1 0.0 7.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain Bunya_G1 PF03557.15 OPL29395.1 - 0.015 13.4 0.1 0.02 12.9 0.1 1.1 1 0 0 1 1 1 0 Bunyavirus glycoprotein G1 AAA_19 PF13245.6 OPL29395.1 - 0.018 15.4 0.0 0.028 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 OPL29395.1 - 0.1 12.1 0.1 0.16 11.4 0.1 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AA_permease_2 PF13520.6 OPL29633.1 - 2.1e-24 86.1 20.3 2.3e-24 86.0 20.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 OPL29633.1 - 5.7e-11 41.7 18.7 6.6e-11 41.5 18.7 1.0 1 0 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.13 OPL29633.1 - 0.038 13.0 14.4 0.054 12.5 14.4 1.2 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family EGF_2 PF07974.13 OPL29717.1 - 0.0011 19.3 13.1 0.0023 18.3 13.1 1.6 1 0 0 1 1 1 1 EGF-like domain DUF1921 PF09081.10 OPL29717.1 - 0.16 12.2 0.2 0.52 10.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1921) EGF PF00008.27 OPL29717.1 - 8.2 6.8 16.8 0.83 10.0 11.2 2.3 2 0 0 2 2 2 0 EGF-like domain IFRD PF05004.13 OPL29755.1 - 7.9e-41 140.1 0.2 1.2e-40 139.6 0.2 1.3 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 OPL29755.1 - 3.3e-21 75.6 0.8 1.9e-19 70.0 0.0 2.3 2 0 0 2 2 2 1 Interferon-related protein conserved region MIEAP PF16026.5 OPL29878.1 - 1.7e-10 41.4 0.1 5.4e-05 23.5 0.0 2.7 1 1 1 2 2 2 2 Mitochondria-eating protein Gal_Lectin PF02140.18 OPL30451.1 - 5e-17 62.1 8.3 8.1e-17 61.4 8.3 1.4 1 0 0 1 1 1 1 Galactose binding lectin domain MFS_1 PF07690.16 OPL30757.1 - 5e-13 48.7 8.9 1.6e-08 33.9 4.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PRRSV_2b PF07069.11 OPL30757.1 - 0.043 14.3 0.1 0.13 12.8 0.1 1.8 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b YrhC PF14143.6 OPL30757.1 - 0.17 12.0 2.2 0.39 10.9 0.1 2.6 3 0 0 3 3 3 0 YrhC-like protein UME PF08064.13 OPL31024.1 - 3.5e-06 26.9 0.1 0.00011 22.0 0.0 2.8 2 0 0 2 2 2 1 UME (NUC010) domain RPAP3_C PF13877.6 OPL31024.1 - 0.036 14.6 0.2 3.3 8.3 0.0 3.0 3 0 0 3 3 3 0 Potential Monad-binding region of RPAP3 HEAT PF02985.22 OPL31558.1 - 5.8e-12 44.8 5.7 0.077 13.3 0.6 5.3 5 0 0 5 5 5 4 HEAT repeat HEAT_EZ PF13513.6 OPL31558.1 - 3.1e-11 43.5 0.4 0.39 11.3 0.0 4.9 5 0 0 5 5 5 4 HEAT-like repeat HEAT_2 PF13646.6 OPL31558.1 - 9.8e-11 41.9 0.9 0.00044 20.6 0.1 4.6 2 1 2 4 4 4 3 HEAT repeats Arm PF00514.23 OPL31558.1 - 9.4e-06 25.5 7.1 0.81 9.8 0.0 5.9 6 1 1 7 7 7 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 OPL31558.1 - 0.0044 17.1 2.6 0.027 14.5 1.4 2.6 1 1 2 3 3 3 1 non-SMC mitotic condensation complex subunit 1 NS3 PF17530.2 OPL31558.1 - 0.041 13.4 0.1 0.078 12.5 0.1 1.4 1 0 0 1 1 1 0 Non-structural protein NS3 HEAT_PBS PF03130.16 OPL31558.1 - 0.058 14.1 2.3 1e+02 4.0 0.0 4.6 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.7 OPL31558.1 - 0.059 14.0 0.7 10 6.8 0.1 3.4 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region PDZ_6 PF17820.1 OPL32171.1 - 3.3e-10 39.6 0.1 8.2e-10 38.4 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 OPL32171.1 - 7.2e-09 35.9 0.2 7.2e-09 35.9 0.2 2.4 3 0 0 3 3 3 1 PDZ domain PDZ_2 PF13180.6 OPL32171.1 - 2e-05 24.8 0.1 4.2e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 OPL32171.1 - 7.9e-05 23.1 1.9 9.2e-05 22.9 0.3 1.9 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 OPL32171.1 - 0.015 15.7 0.9 0.015 15.7 0.9 2.9 4 0 0 4 4 4 0 Pleckstrin homology domain Tricorn_PDZ PF14685.6 OPL32171.1 - 0.14 12.2 0.1 0.51 10.3 0.0 1.9 2 0 0 2 2 2 0 Tricorn protease PDZ domain MMS1_N PF10433.9 OPL32228.1 - 2.4e-74 250.7 0.0 3.7e-72 243.5 0.0 2.6 2 1 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 OPL32228.1 - 0.017 14.5 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 CPSF A subunit region ATP-synt_ab_N PF02874.23 OPL32228.1 - 0.11 13.0 0.0 0.39 11.3 0.0 1.9 1 0 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain XhlA PF10779.9 OPL32228.1 - 2.6 8.3 5.4 2.3 8.5 1.4 2.3 2 0 0 2 2 2 0 Haemolysin XhlA Ank_5 PF13857.6 OPL32597.1 - 0.00027 21.1 0.0 0.00037 20.7 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 OPL32597.1 - 0.0005 20.4 0.3 0.018 15.5 0.1 2.3 2 1 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 OPL32597.1 - 0.00086 19.8 0.0 0.0015 19.1 0.0 1.5 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL32597.1 - 0.0063 17.1 0.0 0.0074 16.8 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 OPL32597.1 - 0.0099 16.3 0.1 0.05 14.2 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeat AIRS_C PF02769.22 OPL32597.1 - 0.082 13.0 0.0 0.093 12.9 0.0 1.2 1 0 0 1 1 1 0 AIR synthase related protein, C-terminal domain Clathrin PF00637.20 OPL32598.1 - 2.7e-12 46.8 9.5 4.1e-10 39.7 3.7 2.9 3 1 0 3 3 3 2 Region in Clathrin and VPS Vps39_2 PF10367.9 OPL32598.1 - 0.00038 20.9 0.7 0.00086 19.7 0.1 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 OPL32598.1 - 0.00071 19.5 0.9 0.0021 18.0 0.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 OPL32598.1 - 0.0046 16.8 1.7 0.0046 16.8 1.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 OPL32598.1 - 0.0068 16.0 0.2 0.0068 16.0 0.2 1.8 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type SCO1-SenC PF02630.14 OPL32598.1 - 0.0082 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 SCO1/SenC zf-RING_11 PF17123.5 OPL32598.1 - 0.01 15.6 3.2 0.037 13.8 3.2 2.0 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_2 PF13639.6 OPL32598.1 - 0.015 15.6 0.7 0.015 15.6 0.7 2.3 3 0 0 3 3 3 0 Ring finger domain zf-C3HC4 PF00097.25 OPL32598.1 - 0.017 15.0 0.7 0.066 13.1 0.7 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PspA_IM30 PF04012.12 OPL32598.1 - 0.018 14.6 0.2 0.018 14.6 0.2 2.3 3 0 0 3 3 3 0 PspA/IM30 family zf-rbx1 PF12678.7 OPL32598.1 - 0.039 14.2 0.7 0.039 14.2 0.7 2.0 2 0 0 2 2 1 0 RING-H2 zinc finger domain zf-C3H2C3 PF17122.5 OPL32598.1 - 0.041 13.9 1.6 0.12 12.5 1.6 1.8 1 0 0 1 1 1 0 Zinc-finger zf-ANAPC11 PF12861.7 OPL32598.1 - 0.052 13.6 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Fib_alpha PF08702.10 OPL32598.1 - 0.14 12.3 6.5 24 5.1 0.3 3.5 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 OPL32598.1 - 0.27 11.3 3.2 0.16 12.0 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TolA_bind_tri PF16331.5 OPL32598.1 - 0.31 11.2 4.3 12 6.1 0.1 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation zf-RING_UBOX PF13445.6 OPL32598.1 - 0.31 11.1 3.7 0.12 12.4 0.6 2.0 2 0 0 2 2 2 0 RING-type zinc-finger Peptidase_C14 PF00656.22 OPL32600.1 - 1.3e-07 31.9 0.1 0.00097 19.2 0.0 2.8 1 1 1 2 2 2 2 Caspase domain adh_short_C2 PF13561.6 OPL32601.1 - 1.5e-34 119.6 0.0 1.9e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 OPL32601.1 - 4.1e-24 85.1 0.0 6.3e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase DUF1776 PF08643.10 OPL32601.1 - 0.088 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DTW PF03942.15 OPL32602.1 - 4.8e-24 85.2 0.0 5.8e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 DTW domain Lep_receptor_Ig PF06328.11 OPL32604.1 - 0.03 14.3 0.1 0.11 12.5 0.1 2.0 1 0 0 1 1 1 0 Ig-like C2-type domain fn3 PF00041.21 OPL32605.1 - 2.2e-12 47.2 0.3 8.2e-12 45.3 0.1 2.2 2 0 0 2 2 1 1 Fibronectin type III domain Septin PF00735.18 OPL32605.1 - 8.2e-09 35.1 0.2 1.8e-08 34.0 0.2 1.5 1 0 0 1 1 1 1 Septin Tissue_fac PF01108.17 OPL32605.1 - 2.9e-05 23.9 0.0 0.00012 21.9 0.0 2.0 1 0 0 1 1 1 1 Tissue factor MMR_HSR1 PF01926.23 OPL32605.1 - 4.8e-05 23.4 0.2 0.00016 21.7 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 OPL32605.1 - 0.00037 20.1 0.1 0.00093 18.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 OPL32605.1 - 0.00062 19.5 0.2 0.0015 18.2 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 OPL32605.1 - 0.00089 19.8 7.2 0.21 12.1 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 OPL32605.1 - 0.0023 18.1 0.0 0.0059 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 OPL32605.1 - 0.0056 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 OPL32605.1 - 0.0099 15.8 2.7 0.016 15.1 0.2 2.7 3 1 0 3 3 3 1 RsgA GTPase TrwB_AAD_bind PF10412.9 OPL32605.1 - 0.014 14.3 1.7 0.19 10.6 0.1 2.6 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 OPL32605.1 - 0.029 14.4 0.2 0.083 12.9 0.2 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 OPL32605.1 - 0.034 13.9 1.0 0.28 10.9 0.4 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation T2SSE PF00437.20 OPL32605.1 - 0.044 12.8 0.0 0.085 11.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 OPL32605.1 - 0.055 14.0 0.0 0.055 14.0 0.0 2.5 3 0 0 3 3 3 0 ABC transporter SRP54 PF00448.22 OPL32605.1 - 0.066 12.8 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 OPL32605.1 - 0.074 12.6 0.1 0.16 11.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 OPL32605.1 - 0.084 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AMP-binding_C_2 PF14535.6 OPL32605.1 - 2.6 8.4 6.4 0.25 11.6 0.5 2.3 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Golgin_A5 PF09787.9 OPL32606.1 - 0.0058 16.1 21.4 0.007 15.9 21.4 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 5 NPV_P10 PF05531.12 OPL32606.1 - 0.21 12.1 10.8 1.1 9.8 0.3 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 OPL32606.1 - 1.4 9.1 16.8 3.1 8.0 12.2 2.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family GIT_CC PF16559.5 OPL32606.1 - 3.1 7.7 15.0 0.95 9.4 1.2 3.4 3 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor SlyX PF04102.12 OPL32606.1 - 5.5 7.7 15.9 0.48 11.1 0.5 3.7 2 2 1 3 3 3 0 SlyX YlqD PF11068.8 OPL32606.1 - 7.4 7.0 21.4 8 6.8 10.1 2.3 1 1 1 2 2 2 0 YlqD protein Ribosomal_L20 PF00453.18 OPL32607.1 - 2.1e-06 27.8 0.4 2.7e-06 27.4 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L20 SSF PF00474.17 OPL32608.1 - 3.8e-30 105.1 4.2 3.8e-30 105.1 4.2 1.6 3 0 0 3 3 3 1 Sodium:solute symporter family VWA PF00092.28 OPL32609.1 - 5.4e-19 69.1 0.2 6.5e-19 68.8 0.2 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL32609.1 - 2.4e-10 41.0 0.2 3.7e-10 40.4 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF1194 PF06707.11 OPL32609.1 - 1.9e-06 27.3 0.2 6.6e-06 25.5 0.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1194) VWA_CoxE PF05762.14 OPL32609.1 - 8.7e-06 25.3 0.1 1.4e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein CD34_antigen PF06365.12 OPL32610.1 - 0.033 13.8 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family FrhB_FdhB_C PF04432.13 OPL32611.1 - 0.026 14.4 0.0 0.045 13.6 0.0 1.3 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus Fibrinogen_C PF00147.18 OPL32613.1 - 2.4e-67 227.0 13.5 3.5e-67 226.4 13.5 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COG2 PF06148.11 OPL32613.1 - 0.079 13.1 2.4 0.12 12.4 2.4 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3781 PF12636.7 OPL32613.1 - 0.44 10.5 3.9 0.53 10.2 0.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3781) CARD PF00619.21 OPL32614.1 - 1.7e-11 44.0 0.0 4.3e-11 42.7 0.0 1.7 1 1 1 2 2 2 1 Caspase recruitment domain Mito_carr PF00153.27 OPL32615.1 - 9.3e-37 124.8 1.4 7.4e-17 61.1 0.0 3.3 4 0 0 4 4 4 3 Mitochondrial carrier protein I-set PF07679.16 OPL32619.1 - 0.0004 20.4 0.0 0.0006 19.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain E1-E2_ATPase PF00122.20 OPL32620.1 - 7.9e-38 129.8 0.0 1.4e-37 129.0 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 OPL32620.1 - 2.7e-14 54.0 0.0 2e-13 51.2 0.0 2.3 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 OPL32620.1 - 1.7e-06 28.0 0.0 3.8e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) RDD PF06271.12 OPL32620.1 - 0.018 15.3 0.1 0.035 14.3 0.1 1.4 1 0 0 1 1 1 0 RDD family IQ PF00612.27 OPL32621.1 - 0.0081 15.9 3.2 0.024 14.4 3.2 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF4041 PF13250.6 OPL32621.1 - 0.023 14.6 0.0 0.071 13.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) CM1 PF03026.15 OPL32622.1 - 0.068 12.5 0.1 0.081 12.3 0.1 1.1 1 0 0 1 1 1 0 Influenza C virus M1 protein DUF2730 PF10805.8 OPL32624.1 - 0.043 13.9 0.4 2 8.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) TolA_bind_tri PF16331.5 OPL32624.1 - 0.082 13.0 0.5 4.4 7.4 0.1 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation Syntaxin-6_N PF09177.11 OPL32624.1 - 0.31 11.6 1.5 7.9 7.1 0.2 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal MIEAP PF16026.5 OPL32625.1 - 5.5e-26 92.0 0.3 9e-25 88.0 0.3 2.1 1 1 0 1 1 1 1 Mitochondria-eating protein Xpo1 PF08389.12 OPL32625.1 - 0.00023 21.2 1.2 0.00068 19.7 1.2 1.8 1 1 0 1 1 1 1 Exportin 1-like protein Cep57_CLD_2 PF14197.6 OPL32625.1 - 0.087 12.9 0.4 0.21 11.7 0.4 1.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 AMP-binding_C PF13193.6 OPL32626.1 - 1.3e-07 32.4 0.0 2.2e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain fn3 PF00041.21 OPL32627.1 - 2.3e-27 95.2 8.2 3.3e-13 49.8 0.3 3.0 3 0 0 3 3 3 2 Fibronectin type III domain F5_F8_type_C PF00754.25 OPL32627.1 - 4.2e-08 33.4 4.6 0.0016 18.6 0.2 2.5 3 0 0 3 3 2 2 F5/8 type C domain Pur_ac_phosph_N PF16656.5 OPL32627.1 - 1.1e-05 26.0 12.3 0.0073 16.9 0.4 3.6 4 0 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain DUF4998 PF16389.5 OPL32627.1 - 1.1e-05 25.1 0.7 0.097 12.3 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function CHB_HEX_C PF03174.13 OPL32627.1 - 0.00014 21.7 0.5 0.79 9.7 0.1 2.6 2 0 0 2 2 2 2 Chitobiase/beta-hexosaminidase C-terminal domain DUF3244 PF11589.8 OPL32627.1 - 0.00019 21.5 0.4 0.41 10.8 0.1 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF3244) PKD PF00801.20 OPL32627.1 - 0.00022 21.0 4.3 0.044 13.6 0.8 2.5 2 0 0 2 2 2 2 PKD domain CarboxypepD_reg PF13620.6 OPL32627.1 - 0.00039 20.6 0.4 0.55 10.5 0.1 2.6 2 0 0 2 2 2 2 Carboxypeptidase regulatory-like domain FlgD_ig PF13860.6 OPL32627.1 - 0.0011 18.8 0.5 2.7 7.9 0.1 3.3 4 0 0 4 4 4 2 FlgD Ig-like domain Y_Y_Y PF07495.13 OPL32627.1 - 0.002 18.0 7.4 0.14 12.1 0.1 3.0 3 0 0 3 3 3 2 Y_Y_Y domain Tissue_fac PF01108.17 OPL32627.1 - 0.0025 17.7 0.0 0.56 10.1 0.0 2.5 2 0 0 2 2 2 1 Tissue factor He_PIG PF05345.12 OPL32627.1 - 0.0078 16.4 6.9 0.43 10.8 1.1 2.4 2 0 0 2 2 2 2 Putative Ig domain PFU PF09070.11 OPL32627.1 - 0.01 16.1 0.5 3.8 7.8 0.1 2.3 2 0 0 2 2 2 0 PFU (PLAA family ubiquitin binding) Lipoprotein_18 PF06804.11 OPL32627.1 - 0.05 12.6 1.5 4.7 6.2 0.1 2.2 2 0 0 2 2 2 0 NlpB/DapX lipoprotein PKD_3 PF16820.5 OPL32627.1 - 0.2 11.4 4.0 2.6 7.8 0.6 2.8 2 0 0 2 2 2 0 PKD-like domain DUF5512 PF17631.2 OPL32627.1 - 0.29 11.2 3.4 2.5 8.1 0.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5512) Peptidase_C14 PF00656.22 OPL32628.1 - 3e-33 115.8 0.1 3.7e-33 115.5 0.1 1.1 1 0 0 1 1 1 1 Caspase domain Pkinase PF00069.25 OPL32630.1 - 1.8e-48 165.2 0.0 3e-48 164.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL32630.1 - 8.4e-30 103.9 0.0 1.5e-29 103.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TBK1_ULD PF18396.1 OPL32630.1 - 9.9e-08 31.8 0.1 2.7e-07 30.4 0.1 1.8 1 1 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Kinase-like PF14531.6 OPL32630.1 - 0.00025 20.5 0.0 0.00046 19.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 OPL32630.1 - 0.0042 15.9 0.0 0.0079 15.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase ubiquitin PF00240.23 OPL32630.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family APH PF01636.23 OPL32630.1 - 0.15 11.9 0.0 0.39 10.6 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Choline_transpo PF04515.12 OPL32631.1 - 7e-43 147.1 11.9 7.8e-43 146.9 11.9 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter KxDL PF10241.9 OPL32632.1 - 0.0089 16.3 1.1 0.0089 16.3 1.1 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein MAP7 PF05672.11 OPL32632.1 - 0.01 15.6 24.0 0.01 15.6 24.0 1.9 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family DDHD PF02862.17 OPL32632.1 - 0.012 15.8 4.1 0.077 13.1 0.9 2.2 2 0 0 2 2 2 0 DDHD domain Dynactin_p62 PF05502.13 OPL32632.1 - 0.038 12.8 5.8 0.07 11.9 5.8 1.4 1 0 0 1 1 1 0 Dynactin p62 family DUF1664 PF07889.12 OPL32632.1 - 0.1 12.6 6.0 1.2 9.1 1.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Connexin PF00029.19 OPL32632.1 - 0.49 10.1 4.6 0.8 9.4 4.6 1.3 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 OPL32632.1 - 1.4 7.6 4.1 2.1 7.0 4.1 1.2 1 0 0 1 1 1 0 Presenilin CAF-1_p150 PF11600.8 OPL32632.1 - 5.8 6.6 39.0 0.16 11.7 32.6 1.6 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal TLD PF07534.16 OPL32633.1 - 8.1e-12 45.5 0.0 1.7e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 TLD MMR_HSR1 PF01926.23 OPL32633.1 - 3.1e-06 27.3 0.0 8e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 OPL32633.1 - 9.1e-06 25.3 0.0 0.0011 18.5 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Septin PF00735.18 OPL32633.1 - 2.5e-05 23.7 0.0 4.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Septin ATP_bind_1 PF03029.17 OPL32633.1 - 0.0018 18.1 0.0 1.6 8.5 0.1 2.2 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 OPL32633.1 - 0.0018 18.2 0.1 0.38 10.6 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 OPL32633.1 - 0.003 17.2 0.3 0.28 10.7 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 OPL32633.1 - 0.014 14.6 0.3 0.096 11.8 0.2 2.2 1 1 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.6 OPL32633.1 - 0.016 15.1 0.1 0.032 14.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Gtr1_RagA PF04670.12 OPL32633.1 - 0.028 13.8 0.1 3 7.1 0.1 2.4 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_5 PF07728.14 OPL32633.1 - 0.043 13.8 0.0 0.28 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.11 OPL32633.1 - 0.089 11.7 0.0 0.2 10.5 0.0 1.5 2 0 0 2 2 2 0 PrkA AAA domain MCM PF00493.23 OPL32633.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain ABC_tran PF00005.27 OPL32633.1 - 0.13 12.7 0.1 0.47 11.0 0.0 1.8 2 0 0 2 2 2 0 ABC transporter TSP_1 PF00090.19 OPL32635.1 - 1.1e-12 47.9 6.7 1.1e-12 47.9 6.7 1.4 2 0 0 2 2 2 1 Thrombospondin type 1 domain TSP_1 PF00090.19 OPL32636.1 - 7.3e-24 83.7 22.0 8.7e-14 51.5 4.5 3.0 3 0 0 3 3 3 2 Thrombospondin type 1 domain CxC6 PF18721.1 OPL32636.1 - 1.3 9.3 10.1 76 3.7 9.5 3.1 1 1 1 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases Avidin PF01382.17 OPL32637.1 - 1.5e-08 35.1 1.2 1.9e-08 34.8 1.2 1.2 1 0 0 1 1 1 1 Avidin family TRAPPC9-Trs120 PF08626.11 OPL32638.1 - 2.3e-18 65.1 0.0 1.5e-17 62.4 0.0 1.9 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF725 PF05267.12 OPL32638.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF725) MIB_HERC2 PF06701.13 OPL32639.1 - 2e-16 60.0 2.9 2e-16 60.0 2.9 2.0 2 1 0 2 2 2 1 Mib_herc2 WWE PF02825.20 OPL32639.1 - 1.3e-06 28.9 0.4 2.3e-06 28.1 0.4 1.5 1 0 0 1 1 1 1 WWE domain SKI PF01202.22 OPL32641.1 - 1.4e-29 103.3 0.0 2e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase Thr_synth_N PF14821.6 OPL32641.1 - 2.2e-19 69.4 0.0 6.3e-19 68.0 0.0 1.7 2 0 0 2 2 2 1 Threonine synthase N terminus AAA_18 PF13238.6 OPL32641.1 - 2e-06 28.4 0.0 4.5e-05 24.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 OPL32641.1 - 0.015 15.7 0.0 0.034 14.6 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) dNK PF01712.19 OPL32641.1 - 0.027 14.3 0.0 9.4 6.0 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase Imm70 PF15601.6 OPL32641.1 - 0.042 13.4 0.0 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 70 AAA_17 PF13207.6 OPL32641.1 - 0.056 13.9 0.0 2.1 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain PALP PF00291.25 OPL32641.1 - 0.17 11.2 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme AAA_33 PF13671.6 OPL32641.1 - 0.21 11.7 0.0 1.5 9.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF3040 PF11239.8 OPL32642.1 - 0.02 15.1 0.1 0.03 14.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) CwsA PF10814.8 OPL32642.1 - 0.071 13.3 0.0 0.098 12.8 0.0 1.2 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA SEA PF01390.20 OPL32642.1 - 0.14 12.3 0.0 0.34 11.0 0.0 1.7 2 0 0 2 2 2 0 SEA domain PALP PF00291.25 OPL32644.1 - 2.3e-31 109.3 0.0 2.7e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme RanGAP1_C PF07834.11 OPL32645.1 - 2e-55 187.2 3.1 2.4e-55 186.9 3.1 1.0 1 0 0 1 1 1 1 RanGAP1 C-terminal domain Pkinase_Tyr PF07714.17 OPL32646.1 - 3.2e-10 39.7 0.3 9.3e-05 21.8 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase PolyG_pol PF01518.16 OPL32646.1 - 0.14 10.9 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Sigma NS protein TMEM154 PF15102.6 OPL32647.1 - 0.0013 18.6 2.0 0.0013 18.6 2.0 9.1 1 1 2 3 3 3 1 TMEM154 protein family SNF2_N PF00176.23 OPL32648.1 - 1.4e-28 99.6 0.3 6.7e-27 94.1 0.1 2.2 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 OPL32648.1 - 1e-13 51.6 0.0 2.4e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 OPL32648.1 - 1.9e-10 40.4 12.2 5e-10 39.0 12.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 OPL32648.1 - 1.5e-09 37.5 8.0 3.7e-09 36.3 8.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 OPL32648.1 - 2.2e-08 33.8 11.5 4.7e-08 32.8 11.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL32648.1 - 2.2e-07 31.1 11.1 2.2e-07 31.1 11.1 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 OPL32648.1 - 4.9e-07 29.8 9.6 9.1e-07 28.9 9.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 OPL32648.1 - 1.6e-06 28.1 10.8 3.5e-06 26.9 10.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 OPL32648.1 - 2.2e-06 27.4 9.2 4.5e-06 26.4 9.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 OPL32648.1 - 5e-06 26.4 9.5 1.3e-05 25.0 9.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 OPL32648.1 - 0.0013 18.5 4.4 0.0029 17.4 4.4 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 OPL32648.1 - 0.0013 18.5 3.2 0.0029 17.4 3.2 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 OPL32648.1 - 0.0026 17.8 5.1 0.0063 16.5 5.1 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 OPL32648.1 - 0.0063 16.5 0.1 0.011 15.6 0.1 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_10 PF16685.5 OPL32648.1 - 0.011 15.8 4.6 0.027 14.6 4.6 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF1644 PF07800.12 OPL32648.1 - 0.035 14.2 3.5 0.067 13.3 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) zf-rbx1 PF12678.7 OPL32648.1 - 0.04 14.2 11.2 0.17 12.2 11.2 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 OPL32648.1 - 0.051 13.3 7.3 0.15 11.8 7.3 1.9 1 0 0 1 1 1 0 RING-like zinc finger RIH_assoc PF08454.11 OPL32649.1 - 9.1e-21 73.6 3.9 1.2e-20 73.2 0.2 2.3 2 0 0 2 2 2 1 RyR and IP3R Homology associated AbiJ_NTD5 PF18865.1 OPL32649.1 - 0.031 14.1 0.1 0.11 12.4 0.1 1.9 1 0 0 1 1 1 0 AbiJ N-terminal domain 5 Fibrinogen_C PF00147.18 OPL32650.1 - 3e-51 174.3 10.2 3e-51 174.3 10.2 2.0 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain SF-assemblin PF06705.11 OPL32650.1 - 0.03 13.7 14.5 0.15 11.3 14.5 1.8 1 1 0 1 1 1 0 SF-assemblin/beta giardin DUF4407 PF14362.6 OPL32650.1 - 0.038 13.4 5.6 0.075 12.4 5.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Corona_S2 PF01601.16 OPL32650.1 - 0.1 11.1 5.1 0.095 11.2 3.8 1.5 1 1 0 1 1 1 0 Coronavirus S2 glycoprotein Baculo_PEP_C PF04513.12 OPL32650.1 - 0.21 11.7 12.8 2.6 8.1 12.8 2.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 OPL32650.1 - 0.21 11.5 10.1 0.84 9.5 4.5 2.1 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain XhlA PF10779.9 OPL32650.1 - 0.22 11.7 8.1 4.1 7.7 2.5 2.5 2 0 0 2 2 2 0 Haemolysin XhlA XPG_I_2 PF12813.7 OPL32650.1 - 0.98 8.8 6.4 1.1 8.7 4.3 1.9 1 1 1 2 2 2 0 XPG domain containing ApoO PF09769.9 OPL32650.1 - 2.1 8.3 5.4 13 5.7 0.6 2.5 1 1 1 2 2 2 0 Apolipoprotein O OmpH PF03938.14 OPL32650.1 - 5.1 7.4 16.5 5.5 7.3 14.4 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Fib_alpha PF08702.10 OPL32650.1 - 5.2 7.2 18.4 3.1 8.0 7.0 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 OPL32650.1 - 5.9 7.0 10.8 2.5 8.1 2.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fibin PF15819.5 OPL32650.1 - 6.2 6.5 8.7 1.5 8.6 3.9 2.1 1 1 1 2 2 2 0 Fin bud initiation factor homologue Prominin PF05478.11 OPL32650.1 - 8.2 4.2 15.1 7 4.5 11.5 1.9 1 1 1 2 2 2 0 Prominin Arf PF00025.21 OPL32651.1 - 3.6e-69 231.7 0.1 4e-69 231.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 OPL32651.1 - 2.8e-14 53.4 0.0 3.9e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL32651.1 - 4e-13 49.3 0.1 4.6e-13 49.1 0.1 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 OPL32651.1 - 2.6e-10 40.0 0.0 2.8e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 OPL32651.1 - 5.8e-10 38.9 1.3 1.6e-08 34.1 0.3 2.3 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 OPL32651.1 - 5.7e-09 35.7 0.0 6.9e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 OPL32651.1 - 0.00012 22.1 0.0 0.00021 21.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 OPL32651.1 - 0.0087 16.0 0.2 0.5 10.2 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Tk-SP_N-pro PF18237.1 OPL32651.1 - 0.0092 16.0 0.1 0.021 14.9 0.1 1.6 1 1 0 1 1 1 1 Tk-SP N-propeptide domain AAA_18 PF13238.6 OPL32651.1 - 0.073 13.6 0.0 0.098 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 OPL32651.1 - 0.081 12.5 0.3 9.4 5.8 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CD20 PF04103.15 OPL32652.1 - 0.00021 21.4 2.3 0.00021 21.4 2.3 2.2 1 1 1 2 2 2 1 CD20-like family DPM2 PF07297.12 OPL32652.1 - 0.23 11.8 0.2 0.23 11.8 0.2 2.6 3 0 0 3 3 3 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) CAMSAP_CH PF11971.8 OPL32654.1 - 1.5 8.7 4.0 13 5.7 0.1 3.0 2 1 1 3 3 3 0 CAMSAP CH domain RAP80_UIM PF18282.1 OPL32654.1 - 9.6 6.1 6.3 6.2 6.7 2.3 2.2 1 1 1 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif fn3 PF00041.21 OPL32655.1 - 5.7e-06 26.6 0.2 0.0053 17.1 0.1 3.5 2 1 0 2 2 2 2 Fibronectin type III domain I-set PF07679.16 OPL32656.1 - 8.2e-09 35.4 3.1 0.058 13.5 0.1 3.9 4 0 0 4 4 4 3 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL32656.1 - 3.7e-08 33.8 6.3 0.083 13.5 0.4 3.8 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 OPL32656.1 - 9.6e-05 22.6 7.2 0.034 14.5 1.8 3.2 2 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 OPL32656.1 - 0.00054 20.1 3.3 0.75 10.0 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain MIB_HERC2 PF06701.13 OPL32659.1 - 2.4e-19 69.3 9.7 3.8e-14 52.7 2.0 2.5 2 0 0 2 2 2 2 Mib_herc2 DUF4314 PF14192.6 OPL32659.1 - 0.0007 19.5 3.0 0.7 9.8 0.2 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4314) PUB PF09409.10 OPL32660.1 - 0.00037 20.4 0.1 0.00086 19.2 0.1 1.6 1 0 0 1 1 1 1 PUB domain VWA PF00092.28 OPL32661.1 - 1.5e-28 100.3 1.9 2.1e-28 99.8 1.9 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL32661.1 - 3.5e-08 34.0 0.3 5.6e-08 33.4 0.3 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 OPL32661.1 - 0.00046 20.4 0.4 0.00071 19.7 0.4 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_3 PF13768.6 OPL32661.1 - 0.0023 17.9 0.1 0.034 14.1 0.1 2.6 1 1 0 1 1 1 1 von Willebrand factor type A domain GATA-N PF05349.12 OPL32661.1 - 0.2 12.0 0.2 0.67 10.2 0.1 1.7 2 0 0 2 2 2 0 GATA-type transcription activator, N-terminal CTD_bind PF04818.13 OPL32662.1 - 0.085 13.7 0.1 33 5.4 0.2 2.8 2 0 0 2 2 2 0 RNA polymerase II-binding domain. tRNA_m1G_MT PF01746.21 OPL32663.1 - 1e-16 61.2 0.0 1.3e-16 60.9 0.0 1.0 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Amnionless PF14828.6 OPL32665.1 - 0.013 14.3 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 Amnionless Insulin_TMD PF17870.1 OPL32665.1 - 0.024 14.7 0.9 0.041 13.9 0.9 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment LPG_synthase_TM PF03706.13 OPL32665.1 - 0.068 12.7 0.0 0.086 12.4 0.0 1.0 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region EphA2_TM PF14575.6 OPL32665.1 - 0.12 13.3 0.4 0.38 11.7 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Tetraspanin PF00335.20 OPL32665.1 - 0.32 10.7 4.8 0.55 9.9 4.8 1.3 1 0 0 1 1 1 0 Tetraspanin family Adeno_E3_CR2 PF02439.15 OPL32665.1 - 1.7 8.4 7.7 2.9 7.7 7.7 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Protocadherin PF08374.11 OPL32665.1 - 3.8 7.4 5.2 1.3 9.0 2.3 1.7 1 1 1 2 2 2 0 Protocadherin Syndecan PF01034.20 OPL32665.1 - 7.2 6.6 6.5 0.45 10.5 0.5 2.1 2 0 0 2 2 2 0 Syndecan domain Phosducin PF02114.16 OPL32666.1 - 0.00034 19.6 3.9 0.00038 19.5 3.6 1.3 1 1 0 1 1 1 1 Phosducin Cu-oxidase_3 PF07732.15 OPL32667.1 - 0.00023 21.1 0.0 0.00032 20.7 0.0 1.2 1 0 0 1 1 1 1 Multicopper oxidase Cadherin PF00028.17 OPL32668.1 - 7.4e-61 202.6 4.2 1.5e-18 67.0 0.2 4.5 4 0 0 4 4 4 4 Cadherin domain Laminin_G_2 PF02210.24 OPL32668.1 - 2.2e-21 76.7 0.0 5.3e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 OPL32668.1 - 1.3e-15 57.7 0.0 2.9e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain Cadherin_3 PF16184.5 OPL32668.1 - 4.5e-07 29.8 6.3 0.00026 21.0 0.9 4.0 4 0 0 4 4 4 2 Cadherin-like Cadherin_2 PF08266.12 OPL32668.1 - 3.6e-05 23.5 0.0 0.069 13.0 0.0 3.3 3 0 0 3 3 3 2 Cadherin-like Big_9 PF17963.1 OPL32668.1 - 0.00064 20.4 6.8 0.52 11.1 0.1 3.6 3 0 0 3 3 3 2 Bacterial Ig domain Cadherin_4 PF17803.1 OPL32668.1 - 0.0025 18.4 14.5 0.17 12.6 0.2 4.0 4 0 0 4 4 4 2 Bacterial cadherin-like domain RET_CLD1 PF17756.1 OPL32668.1 - 0.064 13.6 0.0 0.52 10.6 0.0 2.4 2 0 0 2 2 2 0 RET Cadherin like domain 1 Laminin_EGF PF00053.24 OPL32668.1 - 3.9 7.7 10.0 12 6.2 10.0 1.8 1 0 0 1 1 1 0 Laminin EGF domain AAA_6 PF12774.7 OPL32669.1 - 6.7e-99 331.0 0.0 5.1e-98 328.1 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 OPL32669.1 - 4.6e-70 234.8 0.7 8.8e-66 220.9 0.0 2.6 3 0 0 3 3 3 2 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 OPL32669.1 - 3.8e-18 65.8 0.1 8.1e-18 64.8 0.1 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 OPL32669.1 - 7.9e-16 58.3 0.0 7.7e-08 32.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA PF00004.29 OPL32669.1 - 0.00022 21.6 0.0 0.13 12.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 OPL32669.1 - 0.0024 17.6 0.0 0.14 11.8 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 OPL32669.1 - 0.0045 17.4 0.1 2.1 8.7 0.0 2.8 2 1 0 3 3 3 1 AAA ATPase domain TsaE PF02367.17 OPL32669.1 - 0.016 15.2 0.3 3.3 7.7 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 OPL32669.1 - 0.034 14.4 0.1 14 6.0 0.1 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TrwB_AAD_bind PF10412.9 OPL32669.1 - 0.052 12.5 0.2 0.052 12.5 0.2 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ABC_tran PF00005.27 OPL32669.1 - 0.06 13.9 0.0 8.6 6.9 0.0 2.7 3 0 0 3 3 3 0 ABC transporter AAA_19 PF13245.6 OPL32669.1 - 0.11 12.9 0.1 2.5 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 OPL32669.1 - 0.13 11.6 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF853 PF05872.12 OPL32669.1 - 0.13 10.8 0.1 0.35 9.4 0.0 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) AAA_22 PF13401.6 OPL32669.1 - 0.2 11.9 0.1 9.5 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 OPL32669.1 - 0.25 11.0 0.2 12 5.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_6 PF12774.7 OPL32670.1 - 2.4e-37 128.7 2.9 2.5e-37 128.6 0.1 1.9 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 OPL32670.1 - 2.2e-10 40.2 2.3 5.1e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA PF00004.29 OPL32670.1 - 0.037 14.5 0.8 0.15 12.5 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 OPL32670.1 - 0.063 13.3 0.3 0.45 10.5 0.0 2.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) PSP1 PF04468.12 OPL32670.1 - 0.86 9.9 4.4 9 6.7 0.0 2.9 2 1 0 2 2 2 0 PSP1 C-terminal conserved region Pkinase PF00069.25 OPL32671.1 - 1.2e-58 198.6 0.0 1.3e-58 198.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL32671.1 - 7e-34 117.3 0.0 8.5e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 OPL32671.1 - 4.8e-09 36.0 0.0 1.9e-08 34.0 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 OPL32671.1 - 0.00088 18.7 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_2 PF07719.17 OPL32672.1 - 0.0003 20.7 6.4 0.7 10.2 0.4 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 OPL32672.1 - 0.0022 18.7 0.2 3.6 8.7 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 OPL32672.1 - 0.003 17.8 3.1 0.41 11.0 0.5 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 OPL32672.1 - 0.0034 17.6 0.9 0.9 9.8 0.1 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 OPL32672.1 - 0.0076 16.7 0.1 0.32 11.5 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 OPL32672.1 - 0.062 13.2 2.2 1 9.3 0.6 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 OPL32672.1 - 0.24 11.7 2.5 7.8 7.0 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 OPL32672.1 - 0.25 11.2 1.2 31 4.6 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CH PF00307.31 OPL32674.1 - 1.1e-15 57.7 0.1 1.4e-15 57.4 0.1 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 OPL32674.1 - 7.2e-05 22.5 0.0 0.00011 22.0 0.0 1.2 1 0 0 1 1 1 1 CAMSAP CH domain DUF3069 PF11269.8 OPL32674.1 - 0.19 12.0 0.4 0.39 11.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3069) FoP_duplication PF13865.6 OPL32674.1 - 6.1 7.5 7.1 6.9 7.3 6.2 1.5 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Spc29 PF17082.5 OPL32675.1 - 0.0022 17.9 6.4 0.0042 17.0 6.4 1.5 1 0 0 1 1 1 1 Spindle Pole Component 29 SlyX PF04102.12 OPL32675.1 - 0.019 15.6 1.9 0.019 15.6 1.9 2.4 2 0 0 2 2 2 0 SlyX DUF2587 PF10759.9 OPL32675.1 - 0.021 14.3 1.5 0.028 13.9 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2587) SKICH PF17751.1 OPL32675.1 - 0.067 13.7 0.2 0.26 11.8 0.0 2.1 2 0 0 2 2 2 0 SKICH domain MFAP1 PF06991.11 OPL32675.1 - 0.47 10.3 9.5 1.3 8.9 9.5 1.8 1 1 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing DUF16 PF01519.16 OPL32675.1 - 1.5 9.4 10.1 0.25 11.8 5.3 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Glycos_transf_2 PF00535.26 OPL32676.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 TFIIA PF03153.13 OPL32676.1 - 4.1 7.3 27.8 2 8.3 0.7 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Lectin_C PF00059.21 OPL32677.1 - 2.6e-16 60.3 7.9 2.6e-16 60.3 7.9 1.8 1 1 1 2 2 2 1 Lectin C-type domain DUF2206 PF09971.9 OPL32677.1 - 0.011 14.6 2.1 0.017 13.9 2.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) DUF1962 PF09227.10 OPL32677.1 - 0.069 13.5 1.2 0.24 11.8 0.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1962) Rootletin PF15035.6 OPL32677.1 - 0.084 12.9 1.1 0.7 9.9 0.2 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion SRCR PF00530.18 OPL32678.1 - 0.00077 19.9 0.1 0.0071 16.8 0.0 2.3 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain SKG6 PF08693.10 OPL32678.1 - 0.73 9.3 10.4 1.4 8.4 10.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Paramecium_SA PF01508.16 OPL32678.1 - 4.6 7.7 8.5 0.43 11.0 2.9 2.0 1 1 1 2 2 2 0 Paramecium surface antigen domain C2 PF00168.30 OPL32679.1 - 1.1e-20 73.8 0.0 1.5e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain MLVIN_C PF18697.1 OPL32679.1 - 0.38 10.9 2.0 1 9.5 0.0 2.5 3 1 0 3 3 3 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain fn3 PF00041.21 OPL32680.1 - 1.5e-06 28.4 1.6 0.00016 21.9 0.0 2.6 3 0 0 3 3 3 2 Fibronectin type III domain GATase_3 PF07685.14 OPL32680.1 - 0.14 11.7 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain LSDAT_euk PF18139.1 OPL32682.1 - 2.7e-13 49.9 1.3 6.9e-12 45.3 1.3 2.2 1 1 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 OPL32682.1 - 0.0016 17.7 0.1 0.0044 16.3 0.1 1.6 2 0 0 2 2 2 1 SLOG in TRPM, prokaryote LDcluster4 PF18306.1 OPL32682.1 - 0.079 12.5 0.1 0.41 10.2 0.0 2.0 2 0 0 2 2 2 0 SLOG cluster4 family PBP PF01161.20 OPL32684.1 - 5.9e-10 39.6 0.0 7e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein bZIP_1 PF00170.21 OPL32685.1 - 0.00031 20.8 2.8 0.00031 20.8 2.8 2.0 1 1 1 2 2 2 1 bZIP transcription factor DivIC PF04977.15 OPL32685.1 - 0.00097 18.9 1.8 0.00097 18.9 1.8 2.1 1 1 2 3 3 3 1 Septum formation initiator ADIP PF11559.8 OPL32685.1 - 0.0036 17.4 6.7 0.0048 17.0 6.7 1.3 1 1 0 1 1 1 1 Afadin- and alpha -actinin-Binding Wtap PF17098.5 OPL32685.1 - 0.0076 16.2 4.6 0.013 15.4 4.5 1.3 1 1 0 1 1 1 1 WTAP/Mum2p family K-box PF01486.17 OPL32685.1 - 0.011 15.8 1.0 0.011 15.8 1.0 1.9 1 1 0 1 1 1 0 K-box region GIT_CC PF16559.5 OPL32685.1 - 0.014 15.3 0.3 0.058 13.3 0.0 2.0 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor HAUS6_N PF14661.6 OPL32685.1 - 0.016 14.8 5.0 0.018 14.6 5.0 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF4201 PF13870.6 OPL32685.1 - 0.016 15.0 7.0 0.021 14.6 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) KLRAQ PF10205.9 OPL32685.1 - 0.019 15.2 3.0 0.025 14.8 2.9 1.3 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein YabA PF06156.13 OPL32685.1 - 0.026 15.1 3.7 0.031 14.9 3.7 1.3 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 OPL32685.1 - 0.043 14.3 6.3 0.11 13.0 6.3 1.8 1 1 0 1 1 1 0 Cell division protein ZapB bZIP_2 PF07716.15 OPL32685.1 - 0.047 13.8 1.1 0.23 11.5 0.5 2.1 1 1 2 3 3 3 0 Basic region leucine zipper CENP-H PF05837.12 OPL32685.1 - 0.049 14.0 5.1 0.061 13.7 5.0 1.3 1 1 0 1 1 1 0 Centromere protein H (CENP-H) NYD-SP28_assoc PF14775.6 OPL32685.1 - 0.062 13.4 1.6 5.6 7.1 0.5 2.5 1 1 1 2 2 2 0 Sperm tail C-terminal domain APG6_N PF17675.1 OPL32685.1 - 0.08 13.5 8.9 0.1 13.1 8.9 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Ax_dynein_light PF10211.9 OPL32685.1 - 0.084 12.8 9.6 0.094 12.7 9.6 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Seryl_tRNA_N PF02403.22 OPL32685.1 - 0.12 12.7 6.8 0.15 12.3 6.8 1.3 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HALZ PF02183.18 OPL32685.1 - 0.13 12.5 6.8 0.14 12.4 1.0 3.1 2 1 1 3 3 3 0 Homeobox associated leucine zipper Prefoldin_2 PF01920.20 OPL32685.1 - 0.36 10.8 9.8 0.1 12.6 4.9 2.0 1 1 1 2 2 2 0 Prefoldin subunit SOGA PF11365.8 OPL32685.1 - 0.42 11.8 5.8 0.79 10.9 1.0 2.4 1 1 1 2 2 2 0 Protein SOGA VWA PF00092.28 OPL32686.1 - 5.5e-05 23.5 0.0 7.1e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL32686.1 - 0.00076 20.1 0.0 0.00094 19.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain MIB_HERC2 PF06701.13 OPL32687.1 - 0.00011 22.4 0.7 0.00022 21.4 0.7 1.5 1 0 0 1 1 1 1 Mib_herc2 PrgU PF09627.10 OPL32689.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 PrgU-like protein SPAR_C PF11881.8 OPL32691.1 - 5.2e-14 52.7 20.1 7.4e-14 52.3 7.6 4.0 1 1 1 2 2 2 1 C-terminal domain of SPAR protein ATG16 PF08614.11 OPL32691.1 - 0.00016 21.9 5.4 0.00016 21.9 5.4 2.8 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) Rootletin PF15035.6 OPL32691.1 - 0.00032 20.8 1.2 0.00071 19.7 1.2 1.7 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion UPF0242 PF06785.11 OPL32691.1 - 0.0019 18.4 2.7 0.0051 16.9 2.7 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus PI3K_P85_iSH2 PF16454.5 OPL32691.1 - 0.0026 17.4 3.5 0.0039 16.8 2.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain BRE1 PF08647.11 OPL32691.1 - 0.0062 16.6 2.2 0.021 14.9 2.2 1.9 1 0 0 1 1 1 1 BRE1 E3 ubiquitin ligase APG6_N PF17675.1 OPL32691.1 - 0.0071 16.9 5.7 0.019 15.5 5.7 1.7 1 0 0 1 1 1 1 Apg6 coiled-coil region NRBF2 PF08961.10 OPL32691.1 - 0.014 15.0 2.7 0.037 13.6 2.7 1.7 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Spc7 PF08317.11 OPL32691.1 - 0.015 14.2 4.1 0.024 13.5 4.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 OPL32691.1 - 0.016 15.4 3.6 0.048 13.9 3.6 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF4164 PF13747.6 OPL32691.1 - 0.022 15.0 3.7 0.053 13.8 3.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) YabA PF06156.13 OPL32691.1 - 0.028 15.0 2.2 0.12 13.0 2.2 2.0 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 OPL32691.1 - 0.03 14.7 10.3 0.11 12.9 10.3 2.0 1 0 0 1 1 1 0 Cell division protein ZapB FlaC_arch PF05377.11 OPL32691.1 - 0.055 13.9 2.6 0.13 12.7 2.6 1.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) USP8_interact PF08941.10 OPL32691.1 - 0.074 12.9 1.5 0.14 11.9 1.5 1.4 1 0 0 1 1 1 0 USP8 interacting DUF2968 PF11180.8 OPL32691.1 - 0.084 12.5 6.6 0.18 11.5 6.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) OmpH PF03938.14 OPL32691.1 - 0.11 12.8 3.8 0.24 11.7 3.8 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CENP-H PF05837.12 OPL32691.1 - 0.15 12.4 4.0 0.56 10.6 4.0 1.9 1 0 0 1 1 1 0 Centromere protein H (CENP-H) bZIP_2 PF07716.15 OPL32691.1 - 0.19 11.8 10.1 0.16 12.1 6.3 2.5 1 1 1 2 2 2 0 Basic region leucine zipper bZIP_1 PF00170.21 OPL32691.1 - 0.26 11.4 6.2 1.6 8.9 2.8 2.6 1 1 1 2 2 2 0 bZIP transcription factor TolA_bind_tri PF16331.5 OPL32691.1 - 0.47 10.6 9.2 0.17 12.0 6.2 1.8 2 0 0 2 2 1 0 TolA binding protein trimerisation DivIC PF04977.15 OPL32691.1 - 0.98 9.2 8.8 2 8.3 7.3 2.0 1 1 1 2 2 2 0 Septum formation initiator DUF16 PF01519.16 OPL32691.1 - 1.1 9.7 4.8 0.38 11.3 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 SKA1 PF07160.12 OPL32691.1 - 2.4 8.0 7.8 0.17 11.7 1.5 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 ADIP PF11559.8 OPL32691.1 - 3.6 7.6 10.7 0.26 11.4 4.3 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Peptidase_C14 PF00656.22 OPL32692.1 - 6.1e-11 42.7 2.2 1.1e-09 38.6 2.2 2.3 1 1 0 1 1 1 1 Caspase domain Neur_chan_memb PF02932.16 OPL32692.1 - 0.65 10.0 7.6 0.21 11.6 5.1 1.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RP-C_C PF11800.8 OPL32692.1 - 1.7 8.7 9.6 3.8 7.5 9.6 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region SLC12 PF03522.15 OPL32692.1 - 3.1 6.7 15.3 5.8 5.8 15.3 1.4 1 0 0 1 1 1 0 Solute carrier family 12 DUF4407 PF14362.6 OPL32692.1 - 3.3 7.0 11.2 5.2 6.3 11.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_22 PF13401.6 OPL32693.1 - 1.5e-05 25.3 0.0 3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 OPL32693.1 - 6.6e-05 23.3 0.0 0.00017 22.0 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 OPL32693.1 - 9.6e-05 22.8 0.0 0.00019 21.9 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 OPL32693.1 - 0.0001 21.6 0.0 0.00018 20.9 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_7 PF12775.7 OPL32693.1 - 0.00039 20.0 0.0 0.00062 19.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 OPL32693.1 - 0.00044 20.8 0.4 0.0014 19.2 0.1 2.0 1 1 1 2 2 2 1 ABC transporter AAA_25 PF13481.6 OPL32693.1 - 0.00085 19.0 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 OPL32693.1 - 0.001 19.1 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 OPL32693.1 - 0.0014 18.8 0.0 0.003 17.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 OPL32693.1 - 0.0029 17.5 0.7 0.12 12.3 0.2 2.3 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 OPL32693.1 - 0.0033 18.0 0.2 0.0094 16.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 OPL32693.1 - 0.0042 17.0 0.1 0.01 15.7 0.0 1.7 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 OPL32693.1 - 0.0045 17.3 0.0 0.009 16.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase ParA PF10609.9 OPL32693.1 - 0.0074 15.8 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase IstB_IS21 PF01695.17 OPL32693.1 - 0.0099 15.6 0.1 0.016 14.9 0.1 1.5 1 1 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.16 OPL32693.1 - 0.011 15.2 0.7 0.04 13.4 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.6 OPL32693.1 - 0.011 15.5 0.1 0.02 14.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 OPL32693.1 - 0.019 14.1 0.2 0.045 12.9 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF815) KTI12 PF08433.10 OPL32693.1 - 0.022 14.2 1.8 0.11 12.0 0.0 2.1 1 1 1 2 2 2 0 Chromatin associated protein KTI12 Phage_30_8 PF06019.11 OPL32693.1 - 0.024 14.5 0.1 0.049 13.5 0.1 1.5 1 0 0 1 1 1 0 Phage GP30.8 protein AAA_19 PF13245.6 OPL32693.1 - 0.028 14.8 0.1 0.062 13.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 OPL32693.1 - 0.029 13.7 0.5 0.15 11.4 0.0 2.0 1 1 1 2 2 2 0 KaiC Mg_chelatase PF01078.21 OPL32693.1 - 0.03 13.7 0.0 0.053 12.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 OPL32693.1 - 0.038 14.1 0.1 0.1 12.7 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF836 PF05768.14 OPL32693.1 - 0.087 13.2 0.5 0.42 11.0 0.0 2.0 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) Sigma54_activat PF00158.26 OPL32693.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Ploopntkinase3 PF18751.1 OPL32693.1 - 0.14 12.1 0.2 0.49 10.3 0.0 2.0 3 0 0 3 3 2 0 P-loop Nucleotide Kinase3 YHYH PF14240.6 OPL32694.1 - 8.8e-11 42.1 0.5 2.1e-06 27.9 0.1 2.4 1 1 1 2 2 2 2 YHYH protein DUF4234 PF14018.6 OPL32694.1 - 0.093 12.9 2.1 0.096 12.8 0.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) MIF PF01187.18 OPL32695.1 - 6.8e-11 42.5 0.0 9.4e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) EF-hand_1 PF00036.32 OPL32696.1 - 1.2e-39 130.9 11.4 3.6e-09 35.5 0.1 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 OPL32696.1 - 1.1e-34 118.7 2.2 2.5e-16 59.9 0.3 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 OPL32696.1 - 1.8e-30 102.2 6.1 6.4e-08 31.9 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 OPL32696.1 - 2.7e-26 91.2 8.6 5.1e-12 45.5 0.4 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 OPL32696.1 - 7.4e-26 88.5 7.2 1.3e-08 33.9 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 OPL32696.1 - 2.9e-11 43.5 0.0 3.5e-07 30.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 OPL32696.1 - 3.7e-11 42.9 0.1 6.1e-05 23.0 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.7 OPL32696.1 - 2.9e-08 33.6 0.2 0.036 14.0 0.1 2.9 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 OPL32696.1 - 1.7e-06 28.3 0.0 0.029 14.7 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 OPL32696.1 - 1.2e-05 25.5 0.6 0.025 14.9 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain Armet PF10208.9 OPL32696.1 - 0.00024 21.0 0.9 0.26 11.2 0.6 2.7 1 1 0 2 2 2 2 Degradation arginine-rich protein for mis-folding EF-hand_10 PF14788.6 OPL32696.1 - 0.00062 19.6 0.4 0.029 14.2 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 OPL32696.1 - 0.0008 20.3 0.2 0.41 11.6 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 OPL32696.1 - 0.0034 17.5 1.2 4.5 7.6 1.1 3.2 1 1 0 1 1 1 1 Dockerin type I domain DUF4756 PF15948.5 OPL32696.1 - 0.004 17.0 0.5 0.01 15.7 0.3 1.8 2 1 1 3 3 3 1 Domain of unknown function (DUF4756) Caleosin PF05042.13 OPL32696.1 - 0.016 15.2 0.6 28 4.6 0.0 3.4 1 1 3 4 4 4 0 Caleosin related protein ExbD PF02472.16 OPL32696.1 - 0.024 14.8 0.2 0.054 13.7 0.2 1.8 1 1 0 1 1 1 0 Biopolymer transport protein ExbD/TolR HTH_Tnp_Tc3_2 PF01498.18 OPL32696.1 - 0.025 14.8 0.0 6.1 7.2 0.0 2.3 2 0 0 2 2 2 0 Transposase RNA_binding PF01877.17 OPL32696.1 - 0.043 14.1 0.2 4.5 7.6 0.0 2.2 2 1 0 2 2 2 0 RNA binding DUF3349 PF11829.8 OPL32696.1 - 0.046 14.5 0.0 5.4 7.9 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3349) DUF327 PF03885.13 OPL32696.1 - 0.052 13.5 2.2 0.84 9.6 1.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF327) HTH_21 PF13276.6 OPL32696.1 - 0.068 13.3 0.0 0.61 10.3 0.0 2.1 2 0 0 2 2 2 0 HTH-like domain ClpS PF02617.17 OPL32696.1 - 0.08 12.7 0.1 1.5 8.6 0.0 2.3 1 1 0 2 2 2 0 ATP-dependent Clp protease adaptor protein ClpS T3SS_HrpK1 PF16937.5 OPL32696.1 - 0.1 12.2 0.1 0.34 10.5 0.0 1.8 1 1 1 2 2 2 0 Type III secretion system translocator protein, HrpF B5 PF03484.15 OPL32696.1 - 0.26 11.6 1.9 2 8.8 0.3 2.4 1 1 1 2 2 2 0 tRNA synthetase B5 domain Fmp27_WPPW PF10359.9 OPL32697.1 - 0.0025 16.7 1.3 0.0037 16.2 1.3 1.2 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF3130 PF11328.8 OPL32697.1 - 0.005 17.1 1.3 6.2 7.1 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF3130 Thioredoxin_8 PF13905.6 OPL32697.1 - 0.034 14.5 0.6 8.8 6.7 0.0 3.5 4 0 0 4 4 4 0 Thioredoxin-like FapA PF03961.13 OPL32697.1 - 0.064 11.9 4.4 0.11 11.1 4.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMF_TATA_bd PF12325.8 OPL32697.1 - 0.69 10.2 11.7 0.85 9.9 7.3 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding CLZ PF16526.5 OPL32697.1 - 0.79 10.1 8.1 13 6.2 8.0 2.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Nucleoside_tran PF01733.18 OPL32698.1 - 6e-43 147.4 0.6 6.6e-43 147.2 0.6 1.0 1 0 0 1 1 1 1 Nucleoside transporter DUF2070 PF09843.9 OPL32698.1 - 0.0028 16.0 1.1 0.0033 15.8 1.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) DUF5344 PF17279.2 OPL32699.1 - 1.2 9.7 4.0 0.96 10.1 1.3 2.1 3 0 0 3 3 3 0 Family of unknown function (DUF5344) Phospholip_A2_3 PF09056.11 OPL32700.1 - 0.0067 17.1 1.0 0.0099 16.5 0.5 1.5 1 1 0 1 1 1 1 Prokaryotic phospholipase A2 Folliculin PF11704.8 OPL32700.1 - 0.12 12.2 0.1 0.15 12.0 0.1 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Reprolysin_2 PF13574.6 OPL32701.1 - 1.2e-28 100.3 2.2 1.9e-28 99.7 2.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 OPL32701.1 - 1.3e-26 94.0 3.6 2.3e-26 93.2 3.6 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 OPL32701.1 - 1.6e-19 70.6 1.1 2.6e-19 70.0 1.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 OPL32701.1 - 7.7e-09 35.5 5.1 1.9e-08 34.2 5.1 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 OPL32701.1 - 6.8e-06 26.1 0.9 3.9e-05 23.7 0.1 2.2 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Disintegrin PF00200.23 OPL32701.1 - 0.001 19.8 8.3 0.002 18.9 8.3 1.5 1 0 0 1 1 1 1 Disintegrin Pep_M12B_propep PF01562.19 OPL32701.1 - 0.066 13.4 0.3 0.14 12.4 0.3 1.5 1 0 0 1 1 1 0 Reprolysin family propeptide Macro PF01661.21 OPL32702.1 - 2.5e-37 127.5 1.5 6.4e-29 100.4 1.2 2.3 2 0 0 2 2 2 2 Macro domain Pcc1 PF09341.10 OPL32703.1 - 3e-25 88.1 0.0 3.4e-25 88.0 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 LSDAT_euk PF18139.1 OPL32704.1 - 2.6e-18 66.4 0.0 1.7e-09 37.5 0.0 2.2 2 0 0 2 2 2 2 SLOG in TRPM LSDAT_prok PF18171.1 OPL32704.1 - 3.7e-06 26.3 0.0 6.9e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote MIP PF00230.20 OPL32705.1 - 6.9e-52 176.4 19.2 1.1e-48 165.9 14.7 2.4 2 0 0 2 2 2 2 Major intrinsic protein DUF3397 PF11877.8 OPL32705.1 - 0.027 14.7 2.3 8.2 6.7 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3397) PDZ PF00595.24 OPL32706.1 - 1.7e-24 85.9 0.0 9.7e-14 51.5 0.0 2.4 2 1 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 OPL32706.1 - 7.4e-22 77.0 0.0 2.9e-10 39.8 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 OPL32706.1 - 1.7e-08 34.6 0.0 8.5e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 PDZ domain THEG PF14912.6 OPL32707.1 - 9.4e-32 109.3 17.5 1.2e-10 41.6 1.0 5.2 2 2 2 5 5 5 5 Testicular haploid expressed repeat zf-C2H2_jaz PF12171.8 OPL32708.1 - 3.8e-07 30.2 1.5 6.9e-07 29.4 1.5 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 OPL32708.1 - 1.4e-06 28.5 1.4 2.2e-06 27.9 1.4 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 OPL32708.1 - 0.0002 21.0 1.1 0.00038 20.2 1.1 1.4 1 0 0 1 1 1 1 U1 zinc finger DUF5446 PF17522.2 OPL32708.1 - 0.037 14.2 2.2 0.037 14.2 2.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5446) zf-C2H2 PF00096.26 OPL32708.1 - 0.11 13.1 1.0 0.23 12.0 1.0 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type TIMP PF00965.17 OPL32710.1 - 0.00049 19.9 0.1 0.00052 19.9 0.1 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Yippee-Mis18 PF03226.14 OPL32711.1 - 0.21 11.8 2.7 0.13 12.5 0.6 1.8 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly WSC PF01822.19 OPL32712.1 - 1.2e-17 63.9 8.5 1.6e-17 63.4 8.5 1.2 1 0 0 1 1 1 1 WSC domain PAN_1 PF00024.26 OPL32712.1 - 0.02 14.9 6.7 0.021 14.7 0.4 2.3 1 1 1 2 2 2 0 PAN domain Sushi PF00084.20 OPL32713.1 - 2.3e-05 24.9 0.2 5e-05 23.8 0.2 1.6 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) EphA2_TM PF14575.6 OPL32713.1 - 0.003 18.4 0.0 0.01 16.7 0.0 2.0 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Mid2 PF04478.12 OPL32713.1 - 0.015 15.2 0.0 0.037 13.9 0.0 1.7 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Adeno_E3_CR2 PF02439.15 OPL32713.1 - 0.018 14.8 3.4 0.031 14.0 3.4 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Shisa PF13908.6 OPL32713.1 - 0.032 14.5 0.2 0.24 11.6 0.0 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator CD34_antigen PF06365.12 OPL32713.1 - 0.041 13.5 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Orthoreo_P10 PF07204.11 OPL32713.1 - 0.046 13.7 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Glycophorin_A PF01102.18 OPL32713.1 - 0.098 12.9 0.1 0.31 11.3 0.1 1.8 1 0 0 1 1 1 0 Glycophorin A DAP10 PF07213.11 OPL32713.1 - 0.1 12.5 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 DAP10 membrane protein SIT PF15330.6 OPL32713.1 - 0.13 12.7 0.0 0.52 10.8 0.0 2.0 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Syndecan PF01034.20 OPL32713.1 - 0.15 11.9 1.5 0.28 11.1 1.5 1.4 1 0 0 1 1 1 0 Syndecan domain Fibrinogen_C PF00147.18 OPL32714.1 - 4.3e-18 65.9 2.4 4.9e-18 65.7 2.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SDA1 PF05285.12 OPL32715.1 - 0.0019 17.7 23.2 0.0028 17.1 23.2 1.3 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.14 OPL32715.1 - 0.003 15.9 16.6 0.0041 15.5 16.6 1.2 1 0 0 1 1 1 1 CDC45-like protein Integrase_Zn PF02022.19 OPL32715.1 - 0.13 12.2 0.2 0.29 11.1 0.2 1.6 1 0 0 1 1 1 0 Integrase Zinc binding domain PPP4R2 PF09184.11 OPL32715.1 - 0.34 10.5 25.8 0.067 12.8 21.1 2.2 2 0 0 2 2 2 0 PPP4R2 Presenilin PF01080.17 OPL32715.1 - 4.1 6.1 9.2 7.1 5.3 9.2 1.3 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 OPL32715.1 - 9.4 4.3 33.2 15 3.7 33.2 1.2 1 0 0 1 1 1 0 Nop14-like family Ephrin_rec_like PF07699.13 OPL32716.1 - 3.7e-12 45.8 6.6 3.7e-12 45.8 6.6 3.9 2 1 1 3 3 3 2 Putative ephrin-receptor like SOG2 PF10428.9 OPL32716.1 - 0.0036 16.6 24.1 0.0039 16.5 24.1 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein GREB1 PF15782.5 OPL32716.1 - 1.6 5.8 14.2 1.6 5.7 14.2 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NCD3G PF07562.14 OPL32716.1 - 3.9 7.5 15.5 0.21 11.6 2.0 3.3 2 1 0 3 3 3 0 Nine Cysteines Domain of family 3 GPCR TSP_1 PF00090.19 OPL32717.1 - 9.3e-10 38.6 7.0 9.3e-10 38.6 7.0 4.2 3 1 1 4 4 4 1 Thrombospondin type 1 domain EGF PF00008.27 OPL32717.1 - 2.1e-05 24.7 30.4 0.0003 21.0 9.5 4.2 4 1 0 4 4 4 2 EGF-like domain hEGF PF12661.7 OPL32717.1 - 0.0021 18.6 2.0 0.0021 18.6 2.0 5.4 6 1 0 6 6 6 2 Human growth factor-like EGF EGF_CA PF07645.15 OPL32717.1 - 0.003 17.7 14.8 0.003 17.7 14.8 4.9 3 2 3 6 6 6 1 Calcium-binding EGF domain EGF_3 PF12947.7 OPL32717.1 - 0.013 15.7 40.3 0.65 10.2 11.3 4.2 3 0 0 3 3 3 0 EGF domain Ntox1 PF15500.6 OPL32717.1 - 3 8.2 5.4 1.6 9.1 0.8 2.3 2 0 0 2 2 2 0 Putative RNase-like toxin, toxin_1 Gal-bind_lectin PF00337.22 OPL32718.1 - 1.1e-08 34.6 0.2 1.7e-07 30.8 0.1 2.0 1 1 1 2 2 2 2 Galactoside-binding lectin Cadherin PF00028.17 OPL32719.1 - 3.1e-16 59.6 8.5 0.0015 18.9 0.0 6.1 5 1 1 6 6 6 4 Cadherin domain Cadherin_4 PF17803.1 OPL32719.1 - 0.0037 17.8 25.5 0.034 14.8 0.3 5.5 3 1 0 3 3 3 2 Bacterial cadherin-like domain Cadherin_3 PF16184.5 OPL32719.1 - 0.0064 16.5 1.6 0.33 11.0 0.1 2.9 2 1 0 2 2 2 1 Cadherin-like Big_9 PF17963.1 OPL32719.1 - 0.086 13.6 29.5 0.11 13.3 0.2 5.9 3 2 2 5 5 5 0 Bacterial Ig domain Mab-21 PF03281.14 OPL32721.1 - 3e-35 122.0 0.3 3.4e-35 121.8 0.3 1.0 1 0 0 1 1 1 1 Mab-21 protein DUF4832 PF16116.5 OPL32721.1 - 0.14 12.0 2.1 1.5 8.7 2.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4832) EGF PF00008.27 OPL32722.1 - 0.01 16.2 8.7 0.016 15.5 8.7 1.4 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 OPL32722.1 - 0.26 12.0 6.7 0.54 11.0 6.7 1.5 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.13 OPL32722.1 - 0.28 11.6 10.6 0.44 11.0 10.6 1.3 1 0 0 1 1 1 0 EGF-like domain EGF_alliinase PF04863.13 OPL32722.1 - 0.32 11.4 2.7 0.82 10.1 2.7 1.6 1 0 0 1 1 1 0 Alliinase EGF-like domain Drf_FH1 PF06346.12 OPL32722.1 - 0.66 9.7 5.7 2.4 7.9 5.5 2.1 1 1 0 1 1 1 0 Formin Homology Region 1 DcpS_C PF11969.8 OPL32723.1 - 2.7e-26 92.3 0.5 3.4e-26 91.9 0.5 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 OPL32723.1 - 5.8e-10 39.8 1.7 1.4e-09 38.6 1.7 1.6 1 1 0 1 1 1 1 HIT domain Pox_A9 PF04835.12 OPL32723.1 - 0.013 15.6 1.5 0.018 15.2 0.3 1.8 2 0 0 2 2 2 0 A9 protein conserved region cpYpsA PF12694.7 OPL32724.1 - 0.033 14.0 0.0 2.3 8.0 0.0 2.3 1 1 1 2 2 2 0 Circularly permutated YpsA SLOG family ssDBP_DBD PF18361.1 OPL32724.1 - 0.14 12.2 0.1 12 6.1 0.0 2.5 1 1 1 2 2 2 0 Single stranded DNA-binding protein ss DNA binding domain WAP PF00095.21 OPL32726.1 - 0.0011 19.4 35.1 0.019 15.3 6.7 3.2 3 0 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' Rhodanese PF00581.20 OPL32729.1 - 1.3e-10 41.7 0.1 2.4e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Ig_C19orf38 PF17737.1 OPL32729.1 - 0.068 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Ig domain in C19orf38 (HIDE1) Ank_4 PF13637.6 OPL32730.1 - 6.6e-06 26.6 0.0 1.3e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 OPL32730.1 - 0.00022 21.4 0.2 0.0004 20.6 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL32730.1 - 0.00084 19.9 0.0 0.0015 19.1 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 OPL32730.1 - 0.0023 18.3 0.0 1.2 9.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 OPL32730.1 - 0.0094 16.4 0.0 6 7.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat bPH_3 PF14470.6 OPL32731.1 - 0.0092 16.3 0.0 0.013 15.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial PH domain Myosin_TH1 PF06017.13 OPL32731.1 - 0.063 12.9 0.0 0.071 12.8 0.0 1.1 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding VPS13_C PF16909.5 OPL32732.1 - 7.1e-34 117.1 2.3 4.5e-28 98.2 0.1 2.0 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 OPL32732.1 - 2.9e-07 30.7 0.0 6.7e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_mid_rpt PF16910.5 OPL32734.1 - 0.0016 17.9 0.1 0.004 16.6 0.1 1.6 1 1 0 1 1 1 1 Repeating coiled region of VPS13 DUF4279 PF14106.6 OPL32734.1 - 0.064 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) PH PF00169.29 OPL32735.1 - 0.0017 18.8 0.0 0.0031 18.0 0.0 1.4 1 1 0 1 1 1 1 PH domain PH_6 PF15406.6 OPL32735.1 - 0.014 15.7 0.0 0.021 15.1 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain AMP-binding_C PF13193.6 OPL32736.1 - 2e-25 89.6 0.1 2.8e-25 89.1 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain T2SS-T3SS_pil_N PF13629.6 OPL32736.1 - 0.048 13.4 0.2 6.8 6.5 0.0 2.2 2 0 0 2 2 2 0 Pilus formation protein N terminal region DnaJ_CXXCXGXG PF00684.19 OPL32737.1 - 0.011 16.0 19.8 1 9.8 1.6 2.8 1 1 1 2 2 2 0 DnaJ central domain PRKG1_interact PF15898.5 OPL32738.1 - 5 8.1 16.5 0.89 10.5 10.8 2.0 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4551 PF15087.6 OPL32738.1 - 5.9 5.6 18.2 7.3 5.3 18.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MecA_N PF05223.11 OPL32740.1 - 0.017 15.4 1.6 0.027 14.7 1.6 1.4 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain SKG6 PF08693.10 OPL32740.1 - 0.036 13.5 5.1 0.085 12.3 5.1 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Syndecan PF01034.20 OPL32740.1 - 0.086 12.8 0.2 0.19 11.7 0.2 1.6 1 0 0 1 1 1 0 Syndecan domain Shisa PF13908.6 OPL32740.1 - 0.36 11.0 1.3 0.68 10.2 0.1 1.8 1 1 0 2 2 2 0 Wnt and FGF inhibitory regulator Flp1_like PF16982.5 OPL32740.1 - 0.37 10.2 3.9 0.7 9.3 3.9 1.4 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain EphA2_TM PF14575.6 OPL32740.1 - 0.47 11.4 2.5 0.99 10.3 2.5 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 OPL32740.1 - 4.2 7.3 7.5 1.2 9.1 0.2 2.2 2 0 0 2 2 2 0 TMEM154 protein family DUF1388 PF07142.12 OPL32741.1 - 1.7 8.7 8.1 4 7.5 6.1 2.5 2 1 0 2 2 2 0 Repeat of unknown function (DUF1388) EGF_CA PF07645.15 OPL32742.1 - 1e-08 35.3 5.9 1e-08 35.3 5.9 3.4 2 1 1 3 3 3 1 Calcium-binding EGF domain DUF3139 PF11337.8 OPL32742.1 - 0.02 15.5 0.2 1.6 9.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Epiglycanin_C PF14654.6 OPL32742.1 - 0.021 14.9 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region EGF_2 PF07974.13 OPL32742.1 - 0.021 15.2 9.7 0.021 15.2 9.7 3.1 2 1 0 2 2 2 0 EGF-like domain EGF_3 PF12947.7 OPL32742.1 - 0.038 14.2 4.5 0.038 14.2 4.5 2.8 2 1 0 2 2 2 0 EGF domain hEGF PF12661.7 OPL32742.1 - 0.047 14.3 20.2 0.26 12.0 4.5 3.6 2 1 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 OPL32742.1 - 0.78 10.1 26.0 6.9 7.1 7.7 3.6 2 1 0 2 2 2 0 EGF-like domain FXa_inhibition PF14670.6 OPL32742.1 - 2.4 8.5 21.5 3.7 7.9 7.1 2.7 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site SH3_1 PF00018.28 OPL32743.1 - 0.00014 21.4 0.2 0.00028 20.4 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 OPL32743.1 - 0.0077 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 OPL32743.1 - 0.023 14.3 0.2 0.059 13.1 0.2 1.7 1 0 0 1 1 1 0 Variant SH3 domain Exonuc_VII_L PF02601.15 OPL32743.1 - 0.1 12.1 7.3 0.16 11.5 7.3 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lectin_N PF03954.14 OPL32743.1 - 0.29 10.9 6.4 0.49 10.1 4.4 2.2 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain AATF-Che1 PF13339.6 OPL32743.1 - 0.56 10.9 9.6 0.37 11.5 2.2 2.8 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor MRFAP1 PF15155.6 OPL32743.1 - 0.58 10.7 8.8 4.5 7.8 0.0 3.2 2 1 1 3 3 3 0 MORF4 family-associated protein1 DUF4404 PF14357.6 OPL32743.1 - 0.79 10.4 5.2 0.79 10.4 1.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) CHD5 PF04420.14 OPL32743.1 - 0.86 9.5 7.7 1.9 8.3 7.7 1.6 1 0 0 1 1 1 0 CHD5-like protein DUF1043 PF06295.12 OPL32743.1 - 1.1 9.2 6.8 0.21 11.6 2.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) ADIP PF11559.8 OPL32743.1 - 1.3 9.1 20.9 0.32 11.1 16.2 2.4 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Pkinase PF00069.25 OPL32744.1 - 5.9e-59 199.6 0.1 3.4e-58 197.1 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL32744.1 - 8.8e-42 143.2 0.0 1.4e-41 142.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 OPL32744.1 - 5.9e-10 38.9 0.0 1.1e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 OPL32744.1 - 0.0017 17.8 0.1 0.0032 16.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 OPL32744.1 - 0.14 11.1 0.1 0.14 11.1 0.1 2.5 3 0 0 3 3 3 0 Haspin like kinase domain CEP209_CC5 PF16574.5 OPL32745.1 - 7.5e-40 136.1 20.5 7.5e-40 136.1 20.5 5.2 3 1 4 7 7 7 1 Coiled-coil region of centrosome protein CE290 Spc7 PF08317.11 OPL32745.1 - 0.00042 19.3 16.8 0.00042 19.3 16.8 4.8 2 2 3 5 5 5 2 Spc7 kinetochore protein UPF0184 PF03670.13 OPL32745.1 - 8.8 6.8 13.5 0.29 11.6 2.9 3.8 4 1 1 5 5 5 0 Uncharacterised protein family (UPF0184) Kunitz_BPTI PF00014.23 OPL32746.1 - 1.2e-35 121.5 15.5 4.4e-19 68.5 1.1 3.8 3 1 0 3 3 3 2 Kunitz/Bovine pancreatic trypsin inhibitor domain WAP PF00095.21 OPL32746.1 - 3.5e-10 40.1 44.7 3.4e-09 36.9 17.3 3.7 3 1 0 3 3 3 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' DUF4461 PF14688.6 OPL32747.1 - 9.8e-25 88.0 0.0 1e-24 87.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4461) Lectin_C PF00059.21 OPL32748.1 - 8.2e-19 68.3 0.5 8.2e-19 68.3 0.5 1.6 2 0 0 2 2 2 1 Lectin C-type domain DUF4028 PF13220.6 OPL32748.1 - 0.013 15.3 1.6 0.11 12.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4028) UL45 PF05473.12 OPL32748.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Bromo_TP PF07524.13 OPL32751.1 - 1.2e-08 34.8 0.0 2.3e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated Ldl_recept_b PF00058.17 OPL32753.1 - 1.1e-19 70.6 2.5 5.6e-08 33.1 0.0 3.8 3 1 0 3 3 3 3 Low-density lipoprotein receptor repeat class B DUF5050 PF16472.5 OPL32753.1 - 2.7e-07 30.1 0.1 4e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5050) SGL PF08450.12 OPL32753.1 - 0.0044 16.7 0.2 0.84 9.2 0.0 2.5 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 OPL32753.1 - 0.13 12.5 0.1 2.7 8.2 0.0 2.7 2 1 1 3 3 3 0 Arylesterase YoeB_toxin PF06769.14 OPL32753.1 - 0.15 12.1 0.6 6 7.0 0.2 2.9 2 1 0 2 2 2 0 YoeB-like toxin of bacterial type II toxin-antitoxin system DSL PF01414.19 OPL32754.1 - 0.02 15.1 11.5 0.02 15.1 11.5 2.8 2 1 0 2 2 2 0 Delta serrate ligand UPF0239 PF06783.11 OPL32754.1 - 0.069 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Ank_2 PF12796.7 OPL32755.1 - 1.6e-22 79.9 0.5 1.1e-10 42.0 0.5 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL32755.1 - 1.4e-21 76.6 1.7 1.1e-07 32.2 0.0 4.7 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 OPL32755.1 - 6.1e-19 67.6 8.0 4.6e-05 23.7 0.0 5.3 5 1 1 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 OPL32755.1 - 3.3e-16 57.7 6.5 0.027 15.0 0.0 6.0 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 OPL32755.1 - 5.1e-13 49.0 2.8 0.00019 21.6 0.0 4.4 2 2 3 5 5 5 3 Ankyrin repeats (many copies) SOCS_box PF07525.16 OPL32755.1 - 4.5e-08 33.3 2.8 1.1e-07 32.1 2.8 1.6 1 0 0 1 1 1 1 SOCS box DUF4099 PF13351.6 OPL32756.1 - 0.089 13.1 0.2 0.22 11.8 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4099) fn3 PF00041.21 OPL32757.1 - 8.2e-05 22.9 0.7 0.00013 22.3 0.7 1.2 1 0 0 1 1 1 1 Fibronectin type III domain Peptidase_C14 PF00656.22 OPL32758.1 - 1.9e-08 34.6 0.0 2.5e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Ig_3 PF13927.6 OPL32759.1 - 4.1e-14 52.9 4.8 0.00027 21.5 0.2 4.3 4 0 0 4 4 4 3 Immunoglobulin domain fn3 PF00041.21 OPL32759.1 - 8e-10 38.9 3.8 1.2e-08 35.1 0.5 3.2 4 0 0 4 4 4 1 Fibronectin type III domain I-set PF07679.16 OPL32759.1 - 1.1e-09 38.3 0.1 1.7e-05 24.8 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL32759.1 - 3e-06 27.5 2.2 0.056 13.8 0.2 3.8 4 0 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 OPL32759.1 - 7.2e-05 22.9 1.3 1.4 9.2 0.0 4.0 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 OPL32759.1 - 0.018 15.2 5.6 0.034 14.3 0.1 3.3 3 1 1 4 4 4 0 Immunoglobulin V-set domain F5_F8_type_C PF00754.25 OPL32759.1 - 0.055 13.6 0.3 0.12 12.5 0.3 1.6 1 0 0 1 1 1 0 F5/8 type C domain C2-set_2 PF08205.12 OPL32759.1 - 0.081 13.0 0.0 0.58 10.3 0.0 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Zona_pellucida PF00100.23 OPL32760.1 - 9.8e-06 25.5 2.5 9.8e-06 25.5 2.5 1.7 2 0 0 2 2 2 1 Zona pellucida-like domain AAA_12 PF13087.6 OPL32761.1 - 8.2e-21 74.5 0.4 8.2e-21 74.5 0.4 1.5 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 OPL32761.1 - 5.7e-05 22.9 0.1 0.00014 21.6 0.1 1.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 OPL32761.1 - 0.032 14.0 0.3 0.069 12.9 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase GNAT_acetyltran PF12746.7 OPL32761.1 - 0.096 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase Lipocalin PF00061.23 OPL32762.1 - 0.0012 19.1 0.0 0.0014 18.8 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family VDE PF07137.11 OPL32762.1 - 0.019 14.5 0.0 0.021 14.4 0.0 1.0 1 0 0 1 1 1 0 VDE lipocalin domain CENP-M PF11111.8 OPL32763.1 - 1.4e-30 105.7 0.0 5.3e-16 58.3 0.0 2.4 2 1 0 2 2 2 2 Centromere protein M (CENP-M) Ig_3 PF13927.6 OPL32764.1 - 1.6e-05 25.4 5.2 0.11 13.1 0.1 4.3 3 1 1 4 4 4 3 Immunoglobulin domain I-set PF07679.16 OPL32764.1 - 0.00019 21.5 0.5 5 7.3 0.0 4.3 3 1 2 5 5 5 2 Immunoglobulin I-set domain XendoU PF09412.10 OPL32767.1 - 4.1e-80 268.8 1.1 5e-80 268.5 1.1 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU Glyco_hydro_130 PF04041.13 OPL32767.1 - 0.0036 16.3 0.1 0.0059 15.6 0.1 1.2 1 0 0 1 1 1 1 beta-1,4-mannooligosaccharide phosphorylase TH1 PF04858.13 OPL32767.1 - 0.14 10.7 0.1 0.19 10.3 0.1 1.1 1 0 0 1 1 1 0 TH1 protein Helicase_C PF00271.31 OPL32768.1 - 5.3e-06 26.8 0.0 6.2e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CAP_N PF01213.19 OPL32771.1 - 0.96 8.9 6.1 1.5 8.3 6.1 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Actin PF00022.19 OPL32772.1 - 4.7e-12 45.2 0.0 6.2e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 Actin BIR PF00653.21 OPL32773.1 - 3.9e-52 174.8 13.0 1.8e-19 70.1 0.2 4.6 4 0 0 4 4 4 3 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 OPL32773.1 - 0.18 11.7 3.9 0.089 12.7 0.8 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF5065 PF16723.5 OPL32773.1 - 3.3 7.7 5.5 1.4 9.0 2.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5065) PyrI_C PF02748.15 OPL32773.1 - 6.4 6.8 9.4 3.1 7.8 0.1 3.9 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Ion_trans_2 PF07885.16 OPL32774.1 - 6.8e-25 86.8 11.1 3.8e-16 58.8 3.7 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 OPL32774.1 - 0.00019 20.8 4.9 0.015 14.6 4.9 2.2 1 1 0 1 1 1 1 Ion transport protein Tlr3_TMD PF17968.1 OPL32774.1 - 0.087 13.0 0.4 0.087 13.0 0.4 2.3 2 0 0 2 2 2 0 Toll-like receptor 3 trans-membrane domain Polysacc_deac_1 PF01522.21 OPL32776.1 - 0.2 11.6 1.5 0.38 10.6 0.3 2.1 2 0 0 2 2 2 0 Polysaccharide deacetylase RabGAP-TBC PF00566.18 OPL32777.1 - 0.14 11.8 0.1 0.18 11.5 0.1 1.2 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Rhamnogal_lyase PF06045.11 OPL32779.1 - 0.077 12.4 1.0 0.079 12.4 1.0 1.0 1 0 0 1 1 1 0 Rhamnogalacturonate lyase family VWA_3 PF13768.6 OPL32782.1 - 9e-13 48.4 0.0 1.6e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 OPL32782.1 - 0.015 15.6 0.1 0.025 14.8 0.1 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain TRAM_LAG1_CLN8 PF03798.16 OPL32783.1 - 5.2e-11 42.7 12.7 5.2e-11 42.7 12.7 1.8 2 0 0 2 2 2 1 TLC domain DUF805 PF05656.14 OPL32783.1 - 6.3 7.3 7.7 31 5.0 7.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF805) Lectin_C PF00059.21 OPL32784.1 - 2.1e-14 54.2 5.2 2.1e-14 54.2 5.2 1.8 1 1 1 2 2 2 1 Lectin C-type domain Baculo_PEP_C PF04513.12 OPL32784.1 - 0.00071 19.6 0.1 0.00095 19.2 0.1 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4618 PF15397.6 OPL32784.1 - 0.071 12.5 0.2 0.095 12.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) AAA_assoc_2 PF16193.5 OPL32784.1 - 0.15 12.5 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA C-terminal domain Cadherin PF00028.17 OPL32785.1 - 3e-48 162.2 7.4 8.5e-14 51.8 0.8 4.7 4 1 0 4 4 4 4 Cadherin domain Cadherin_3 PF16184.5 OPL32785.1 - 4.5e-05 23.4 5.5 0.091 12.8 0.1 3.5 3 0 0 3 3 3 3 Cadherin-like Cadherin_4 PF17803.1 OPL32785.1 - 0.0035 17.9 11.9 0.037 14.7 4.3 3.7 2 1 1 3 3 3 2 Bacterial cadherin-like domain FctA PF12892.7 OPL32785.1 - 1.3 9.9 10.3 18 6.2 2.1 3.8 1 1 1 2 2 2 0 Spy0128-like isopeptide containing domain Cadherin PF00028.17 OPL32786.1 - 3.4e-28 97.9 1.9 2.6e-13 50.2 0.0 2.4 2 0 0 2 2 2 2 Cadherin domain Cadherin_3 PF16184.5 OPL32786.1 - 0.0017 18.3 4.6 0.73 9.9 0.1 4.0 3 2 0 3 3 3 2 Cadherin-like PepSY PF03413.19 OPL32786.1 - 0.018 15.6 0.2 0.48 11.0 0.1 3.0 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain Cadherin_2 PF08266.12 OPL32786.1 - 0.026 14.4 0.0 4.3 7.2 0.0 2.4 2 0 0 2 2 2 0 Cadherin-like RET_CLD1 PF17756.1 OPL32786.1 - 0.052 13.8 0.0 3.5 7.9 0.0 2.3 1 1 1 2 2 2 0 RET Cadherin like domain 1 Peptidase_S66 PF02016.15 OPL32786.1 - 0.065 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain Cation_ATPase PF13246.6 OPL32787.1 - 0.0012 18.8 0.0 0.0017 18.4 0.0 1.2 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Toxin_31 PF08119.11 OPL32787.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Scorpion acidic alpha-KTx toxin family Rho_GDI PF02115.17 OPL32788.1 - 9.1e-58 195.2 7.8 1.5e-43 148.8 1.0 2.0 1 1 1 2 2 2 2 RHO protein GDP dissociation inhibitor Tap-RNA_bind PF09162.10 OPL32788.1 - 0.0073 16.1 0.4 2.6 7.9 0.1 2.2 1 1 1 2 2 2 2 Tap, RNA-binding VF530 PF09905.9 OPL32788.1 - 0.015 15.5 1.5 6 7.1 0.0 2.8 3 0 0 3 3 3 0 DNA-binding protein VF530 SusF_SusE PF16411.5 OPL32788.1 - 0.019 15.5 0.3 3.6 8.1 0.1 2.2 1 1 1 2 2 2 0 Outer membrane protein SusF_SusE YjcQ PF09639.10 OPL32788.1 - 0.02 15.1 0.0 0.037 14.2 0.0 1.4 1 0 0 1 1 1 0 YjcQ protein Mur_ligase PF01225.25 OPL32788.1 - 0.15 12.4 0.0 2.9 8.3 0.0 2.1 2 0 0 2 2 2 0 Mur ligase family, catalytic domain DBD_Tnp_Hermes PF10683.9 OPL32788.1 - 0.21 11.3 1.7 4.9 6.9 0.2 2.4 2 0 0 2 2 2 0 Hermes transposase DNA-binding domain Lyase_8_N PF08124.11 OPL32789.1 - 0.054 12.4 0.1 0.13 11.2 0.0 1.5 1 1 1 2 2 2 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DUF4145 PF13643.6 OPL32789.1 - 0.13 12.4 0.3 0.25 11.5 0.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4145) DUF948 PF06103.11 OPL32789.1 - 0.32 11.3 0.9 2.6 8.4 0.1 2.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) BIR PF00653.21 OPL32790.1 - 4.5e-10 40.0 3.2 8.6e-10 39.1 3.2 1.4 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain TraI_2 PF07514.11 OPL32791.1 - 0.05 12.5 0.1 0.082 11.8 0.1 1.2 1 0 0 1 1 1 0 Putative helicase Gal_Lectin PF02140.18 OPL32792.1 - 5.2e-05 23.6 2.8 7.3e-05 23.1 2.8 1.3 1 0 0 1 1 1 1 Galactose binding lectin domain Ig_2 PF13895.6 OPL32794.1 - 1.1e-12 48.1 2.3 1.6e-09 37.9 0.6 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 OPL32794.1 - 1.3e-12 48.1 4.5 2e-08 34.7 1.9 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL32794.1 - 7.9e-06 25.9 0.6 0.0026 17.8 0.1 3.1 1 1 1 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 OPL32794.1 - 0.00095 19.3 1.9 0.06 13.5 0.7 2.9 1 1 1 2 2 2 1 Immunoglobulin domain Ig_4 PF16680.5 OPL32794.1 - 0.0011 19.2 0.2 0.0011 19.2 0.2 1.6 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 OPL32794.1 - 0.015 15.7 0.1 0.039 14.4 0.1 1.6 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 OPL32794.1 - 0.17 12.3 1.3 0.95 9.9 0.2 2.3 2 0 0 2 2 2 0 Immunoglobulin C1-set domain V-set PF07686.17 OPL32794.1 - 0.21 11.8 4.7 2.6 8.3 0.3 3.0 2 1 2 4 4 4 0 Immunoglobulin V-set domain zf-RRN7 PF11781.8 OPL32794.1 - 0.22 11.2 1.6 5.9 6.7 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 VWA PF00092.28 OPL32795.1 - 7.2e-35 120.8 0.1 9.9e-35 120.3 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL32795.1 - 1.7e-13 51.2 0.0 3.1e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 OPL32795.1 - 0.0045 16.4 0.0 0.0076 15.7 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 OPL32795.1 - 0.15 12.0 0.0 0.4 10.6 0.0 1.8 1 1 0 1 1 1 0 von Willebrand factor type A domain DUF968 PF06147.11 OPL32796.1 - 0.026 14.8 0.0 0.053 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF968) Glu_cys_ligase PF04262.14 OPL32796.1 - 1.8 7.1 13.3 0.62 8.6 9.2 2.0 1 1 1 2 2 2 0 Glutamate-cysteine ligase Fibrinogen_C PF00147.18 OPL32797.1 - 3.1e-75 252.8 19.1 3.5e-75 252.6 19.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ta0938 PF11494.8 OPL32797.1 - 0.93 9.8 5.8 0.19 12.0 1.0 2.2 2 1 1 3 3 3 0 Ta0938 Death PF00531.22 OPL32798.1 - 1.1e-09 38.2 0.2 1.8e-09 37.6 0.2 1.3 1 0 0 1 1 1 1 Death domain Enkurin PF13864.6 OPL32798.1 - 0.12 12.8 0.1 0.21 12.1 0.1 1.3 1 0 0 1 1 1 0 Calmodulin-binding HSP70 PF00012.20 OPL32799.1 - 1.2e-12 46.8 1.0 2.2e-11 42.7 1.1 2.2 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL32799.1 - 0.014 14.3 0.1 0.24 10.2 0.0 2.3 2 0 0 2 2 2 0 MreB/Mbl protein PH PF00169.29 OPL32800.1 - 2.3e-12 47.3 0.1 6.7e-08 33.0 0.0 2.0 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 OPL32800.1 - 3.6e-07 30.6 0.1 0.002 18.6 0.0 2.2 1 1 1 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 OPL32800.1 - 0.00071 19.8 0.0 1.4 9.2 0.0 2.2 2 0 0 2 2 2 2 Pleckstrin homology domain DUF1367 PF07105.11 OPL32800.1 - 0.0079 15.9 0.1 1.2 8.7 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1367) PhyH PF05721.13 OPL32801.1 - 2.6e-09 37.6 0.1 7.2e-09 36.2 0.1 1.7 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Rad9 PF04139.13 OPL32801.1 - 0.055 12.9 0.0 0.079 12.4 0.0 1.2 1 0 0 1 1 1 0 Rad9 TTKRSYEDQ PF10212.9 OPL32802.1 - 2.1e-40 139.3 9.7 2.2e-40 139.1 9.7 1.0 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein ATG16 PF08614.11 OPL32802.1 - 0.00011 22.6 12.8 0.0026 18.0 5.6 2.0 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 OPL32802.1 - 0.00014 21.9 10.4 0.00017 21.6 10.4 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 OPL32802.1 - 0.00025 20.0 8.8 0.00031 19.7 8.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF1664 PF07889.12 OPL32802.1 - 0.00077 19.5 5.3 0.18 11.9 0.9 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) BID PF06393.11 OPL32802.1 - 0.00098 18.7 2.7 0.0012 18.5 2.7 1.2 1 0 0 1 1 1 1 BH3 interacting domain (BID) Fez1 PF06818.15 OPL32802.1 - 0.0031 18.0 7.1 0.0039 17.7 7.1 1.1 1 0 0 1 1 1 1 Fez1 Fib_alpha PF08702.10 OPL32802.1 - 0.0034 17.6 8.3 0.013 15.7 8.3 1.6 1 1 0 1 1 1 1 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.9 OPL32802.1 - 0.0041 16.6 10.7 0.015 14.8 10.7 1.7 1 1 0 1 1 1 1 Golgin subfamily A member 5 Lebercilin PF15619.6 OPL32802.1 - 0.0048 16.6 9.2 0.0048 16.6 9.2 1.9 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Tropomyosin PF00261.20 OPL32802.1 - 0.0051 16.2 8.4 0.0075 15.7 8.4 1.2 1 0 0 1 1 1 1 Tropomyosin HAP1_N PF04849.13 OPL32802.1 - 0.0082 15.4 10.5 0.15 11.3 1.5 2.0 1 1 1 2 2 2 2 HAP1 N-terminal conserved region MAD PF05557.13 OPL32802.1 - 0.0082 14.6 9.6 0.014 13.8 3.9 2.0 1 1 1 2 2 2 1 Mitotic checkpoint protein CC2-LZ PF16516.5 OPL32802.1 - 0.022 15.1 10.1 0.51 10.7 1.5 2.5 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator IFT57 PF10498.9 OPL32802.1 - 0.024 13.6 7.5 0.031 13.3 7.5 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 HrpB7 PF09486.10 OPL32802.1 - 0.024 15.0 4.0 0.46 10.8 1.0 2.0 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Filament PF00038.21 OPL32802.1 - 0.028 14.0 9.1 0.29 10.7 4.4 1.7 1 1 1 2 2 2 0 Intermediate filament protein SlyX PF04102.12 OPL32802.1 - 0.031 14.9 0.8 0.031 14.9 0.8 2.8 1 1 1 2 2 2 0 SlyX Troponin PF00992.20 OPL32802.1 - 0.032 14.5 7.1 0.25 11.7 5.7 2.1 1 1 1 2 2 2 0 Troponin KASH_CCD PF14662.6 OPL32802.1 - 0.034 14.0 10.0 0.045 13.6 10.0 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH PKcGMP_CC PF16808.5 OPL32802.1 - 0.039 13.8 6.4 0.047 13.6 0.2 3.1 4 0 0 4 4 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Phage_GPO PF05929.11 OPL32802.1 - 0.039 13.6 7.9 0.043 13.4 7.9 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Tropomyosin_1 PF12718.7 OPL32802.1 - 0.047 13.8 11.0 0.24 11.5 10.9 1.8 1 1 0 1 1 1 0 Tropomyosin like HrpB2 PF09487.10 OPL32802.1 - 0.05 14.0 2.2 0.33 11.4 0.5 2.1 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB2) DHR10 PF18595.1 OPL32802.1 - 0.055 13.5 11.7 0.12 12.5 11.8 1.5 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain EzrA PF06160.12 OPL32802.1 - 0.056 11.6 8.6 0.073 11.2 8.6 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA PspA_IM30 PF04012.12 OPL32802.1 - 0.071 12.7 9.9 0.16 11.5 9.9 1.5 1 1 0 1 1 1 0 PspA/IM30 family Snapin_Pallidin PF14712.6 OPL32802.1 - 0.075 13.5 7.1 0.11 13.0 3.3 2.0 1 1 1 2 2 2 0 Snapin/Pallidin R2K_2 PF18299.1 OPL32802.1 - 0.082 12.8 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Meis_PKNOX_N PF16493.5 OPL32802.1 - 0.084 13.2 1.3 9.9 6.6 0.2 2.2 2 0 0 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 DUF4407 PF14362.6 OPL32802.1 - 0.096 12.0 5.5 0.16 11.3 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1501 PF07394.12 OPL32802.1 - 0.097 11.7 3.7 0.1 11.6 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF3584 PF12128.8 OPL32802.1 - 0.11 10.0 11.1 0.12 9.9 11.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DASH_Dam1 PF08653.10 OPL32802.1 - 0.12 12.2 0.5 0.36 10.7 0.0 2.1 2 2 1 3 3 3 0 DASH complex subunit Dam1 DUF16 PF01519.16 OPL32802.1 - 0.12 12.9 5.8 0.31 11.5 4.0 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF948 PF06103.11 OPL32802.1 - 0.13 12.5 1.5 0.25 11.6 0.5 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Cep57_CLD_2 PF14197.6 OPL32802.1 - 0.17 12.0 7.8 0.22 11.7 0.2 2.9 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 DUF4618 PF15397.6 OPL32802.1 - 0.18 11.2 9.6 0.35 10.2 9.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) DUF4201 PF13870.6 OPL32802.1 - 0.19 11.5 11.1 1.1 9.0 4.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) CorA PF01544.18 OPL32802.1 - 0.19 11.0 3.0 0.21 10.9 3.0 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Bacillus_HBL PF05791.11 OPL32802.1 - 0.2 11.5 7.2 0.73 9.6 2.6 1.9 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) YabA PF06156.13 OPL32802.1 - 0.22 12.2 7.6 1.2 9.8 2.2 2.1 1 1 1 2 2 2 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 OPL32802.1 - 0.23 11.5 14.1 0.2 11.7 11.2 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein FUSC PF04632.12 OPL32802.1 - 0.27 9.7 1.5 0.31 9.5 1.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3450 PF11932.8 OPL32802.1 - 0.28 10.5 9.4 0.37 10.0 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Tup_N PF08581.10 OPL32802.1 - 0.32 11.3 9.0 1.4 9.3 1.4 3.1 1 1 2 3 3 3 0 Tup N-terminal DMPK_coil PF08826.10 OPL32802.1 - 0.32 11.1 6.8 0.76 9.9 0.1 2.8 1 1 2 3 3 3 0 DMPK coiled coil domain like XhlA PF10779.9 OPL32802.1 - 0.35 11.1 6.2 6.4 7.1 0.1 3.0 1 1 2 3 3 3 0 Haemolysin XhlA Atg14 PF10186.9 OPL32802.1 - 0.36 9.9 10.2 0.39 9.8 10.2 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Laminin_II PF06009.12 OPL32802.1 - 0.38 10.8 5.7 1.7 8.6 5.7 1.8 1 1 0 1 1 1 0 Laminin Domain II Jnk-SapK_ap_N PF09744.9 OPL32802.1 - 0.44 10.7 11.2 0.68 10.1 11.2 1.4 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 TMF_TATA_bd PF12325.8 OPL32802.1 - 0.47 10.7 10.5 1.8 8.8 10.4 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF4140 PF13600.6 OPL32802.1 - 0.52 10.8 7.4 19 5.8 7.4 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) FapA PF03961.13 OPL32802.1 - 0.65 8.5 6.3 0.74 8.3 6.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A ADIP PF11559.8 OPL32802.1 - 0.67 10.0 11.8 3.3 7.8 11.6 1.8 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 OPL32802.1 - 0.73 9.9 13.4 2.2 8.3 1.6 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Exonuc_VII_L PF02601.15 OPL32802.1 - 1 8.8 8.3 1.2 8.6 8.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med9 PF07544.13 OPL32802.1 - 1.3 9.2 8.4 21 5.3 6.1 2.8 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 UPF0242 PF06785.11 OPL32802.1 - 2 8.5 11.7 2.5 8.1 11.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Bap31_Bap29_C PF18035.1 OPL32802.1 - 2.4 8.2 14.0 1.2 9.2 1.4 3.0 1 1 2 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain TMPIT PF07851.13 OPL32802.1 - 4.1 6.6 8.1 5.8 6.1 8.1 1.3 1 1 0 1 1 1 0 TMPIT-like protein DUF2802 PF10975.8 OPL32802.1 - 5.5 7.2 9.0 2.1 8.5 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2802) Spc24 PF08286.11 OPL32802.1 - 5.5 7.3 10.8 40 4.5 2.4 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Band_7 PF01145.25 OPL32803.1 - 3e-18 66.5 7.2 3.9e-18 66.1 2.5 2.2 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 OPL32803.1 - 0.00034 20.4 0.0 0.00063 19.5 0.0 1.5 1 0 0 1 1 1 1 SPFH domain-Band 7 family HrpA_pilin PF09589.10 OPL32803.1 - 0.1 13.3 2.0 0.26 12.0 2.0 1.7 1 0 0 1 1 1 0 HrpA pilus formation protein TFIID-31kDa PF02291.15 OPL32803.1 - 0.18 11.8 1.4 0.67 10.0 0.6 2.1 1 1 1 2 2 2 0 Transcription initiation factor IID, 31kD subunit Halo_GVPC PF05465.13 OPL32803.1 - 9.5 6.6 7.8 6 7.2 0.1 3.3 4 0 0 4 4 4 0 Halobacterial gas vesicle protein C (GVPC) repeat EGF_2 PF07974.13 OPL32804.1 - 9.2e-11 41.9 55.2 0.0001 22.6 7.7 4.1 4 0 0 4 4 4 4 EGF-like domain EGF PF00008.27 OPL32804.1 - 8.8e-09 35.5 45.6 0.00046 20.4 8.7 4.8 4 1 0 4 4 4 4 EGF-like domain hEGF PF12661.7 OPL32804.1 - 0.0029 18.2 9.6 0.0029 18.2 9.6 5.8 7 0 0 7 7 7 3 Human growth factor-like EGF Laminin_EGF PF00053.24 OPL32804.1 - 0.033 14.3 44.3 0.37 11.0 7.1 4.2 1 1 3 4 4 4 0 Laminin EGF domain DUF1477 PF07346.11 OPL32805.1 - 0.038 14.2 3.7 0.06 13.6 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1477) SEFIR PF08357.11 OPL32806.1 - 5.9e-15 55.8 0.6 1e-14 55.0 0.6 1.4 1 0 0 1 1 1 1 SEFIR domain Rick_17kDa_Anti PF05433.15 OPL32806.1 - 0.25 11.3 0.0 0.39 10.6 0.0 1.2 1 0 0 1 1 1 0 Glycine zipper 2TM domain HEPN_DZIP3 PF18738.1 OPL32807.1 - 3.8e-18 65.6 0.6 8.4e-18 64.5 0.1 1.7 2 0 0 2 2 2 1 DZIP3/ hRUL138-like HEPN HEPN_RiboL-PSP PF18735.1 OPL32807.1 - 0.00016 21.7 0.4 0.00035 20.6 0.0 1.7 2 0 0 2 2 2 1 RiboL-PSP-HEPN DUF4559 PF15112.6 OPL32807.1 - 0.012 15.3 1.1 0.02 14.6 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF1664 PF07889.12 OPL32807.1 - 0.09 12.8 0.4 0.19 11.8 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Collagen PF01391.18 OPL32808.1 - 1e-47 159.7 133.3 1.5e-09 37.4 22.4 6.3 1 1 3 4 4 4 3 Collagen triple helix repeat (20 copies) Lectin_C PF00059.21 OPL32810.1 - 6.3e-30 104.1 16.0 1.3e-15 58.0 0.5 3.4 2 1 0 2 2 2 2 Lectin C-type domain UL45 PF05473.12 OPL32810.1 - 0.00068 19.3 2.1 0.11 12.1 1.2 2.6 2 1 0 2 2 2 2 UL45 protein, carbohydrate-binding C-type lectin-like DUF4490 PF14892.6 OPL32811.1 - 3.4e-39 133.0 0.6 4.7e-39 132.6 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4490) Abhydrolase_9_N PF15420.6 OPL32812.1 - 0.03 14.3 0.8 0.04 13.9 0.8 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Death PF00531.22 OPL32813.1 - 1e-10 41.6 0.0 1.7e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Death domain RHIM PF12721.7 OPL32813.1 - 0.00015 22.2 5.0 0.00015 22.2 5.0 1.8 2 0 0 2 2 2 1 RIP homotypic interaction motif C1q PF00386.21 OPL32814.1 - 9.3e-22 77.6 1.1 2.2e-21 76.4 1.1 1.7 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL32814.1 - 0.0025 17.7 0.8 0.0042 17.0 0.8 1.3 1 0 0 1 1 1 1 BclA C-terminal domain Dynein_C PF18199.1 OPL32814.1 - 0.0097 15.2 1.6 0.015 14.5 1.6 1.3 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain Focal_AT PF03623.13 OPL32814.1 - 0.034 14.1 1.6 0.06 13.3 0.7 1.8 1 1 0 1 1 1 0 Focal adhesion targeting region C2-set_2 PF08205.12 OPL32815.1 - 2.3e-16 59.6 0.1 9.6e-12 44.8 0.1 2.6 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 OPL32815.1 - 5.1e-10 39.8 0.1 3.5e-05 24.3 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 OPL32815.1 - 2.4e-06 27.8 0.2 0.00018 21.8 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin domain C1-set PF07654.15 OPL32815.1 - 8.3e-05 22.9 0.1 0.00027 21.3 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain ig PF00047.25 OPL32815.1 - 0.00024 21.2 0.2 0.0035 17.5 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin domain PKD_3 PF16820.5 OPL32815.1 - 0.2 11.4 0.8 1.4 8.7 0.1 2.5 3 0 0 3 3 3 0 PKD-like domain C1q PF00386.21 OPL32816.1 - 4.5e-10 39.8 0.1 6.8e-10 39.2 0.1 1.3 1 0 0 1 1 1 1 C1q domain Tape_meas_lam_C PF09718.10 OPL32816.1 - 0.036 14.2 0.4 0.1 12.7 0.2 1.8 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF4945 PF16303.5 OPL32817.1 - 0.022 14.7 0.7 0.047 13.6 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4945) Vps5 PF09325.10 OPL32817.1 - 0.029 13.9 5.2 0.038 13.5 5.2 1.1 1 0 0 1 1 1 0 Vps5 C terminal like TolA PF06519.11 OPL32817.1 - 0.077 13.2 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 TolA C-terminal DUF4140 PF13600.6 OPL32817.1 - 0.1 13.0 0.9 0.3 11.6 0.9 1.7 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) SET PF00856.28 OPL32819.1 - 2.9e-08 34.3 0.0 4.2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 SET domain Chitin_synth_2 PF03142.15 OPL32820.1 - 4.3e-15 55.3 1.7 2.1e-06 26.7 0.1 3.3 2 1 1 3 3 3 3 Chitin synthase Glyco_trans_2_3 PF13632.6 OPL32820.1 - 1.7e-07 31.3 1.9 0.00014 21.9 0.9 2.4 1 1 1 2 2 2 2 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 OPL32820.1 - 2.4e-05 24.2 0.0 7.8e-05 22.5 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 OPL32820.1 - 0.0073 16.2 2.7 0.12 12.3 0.3 2.4 1 1 1 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 OPL32820.1 - 0.0091 15.5 0.6 0.058 12.9 0.1 2.4 2 1 1 3 3 3 1 Glycosyl transferase family 21 MIEAP PF16026.5 OPL32821.1 - 8e-26 91.5 1.8 8e-26 91.5 1.8 2.7 2 1 0 2 2 2 1 Mitochondria-eating protein ZapB PF06005.12 OPL32821.1 - 5.6e-05 23.5 22.2 0.0015 19.0 0.5 2.9 2 0 0 2 2 2 1 Cell division protein ZapB Spc7 PF08317.11 OPL32821.1 - 0.00087 18.3 21.0 0.00087 18.3 21.0 1.7 2 0 0 2 2 2 1 Spc7 kinetochore protein TMF_DNA_bd PF12329.8 OPL32821.1 - 0.0032 17.4 8.2 0.0032 17.4 8.2 3.1 3 0 0 3 3 3 1 TATA element modulatory factor 1 DNA binding HOOK PF05622.12 OPL32821.1 - 0.0032 15.7 20.8 0.0061 14.8 20.8 1.4 1 0 0 1 1 1 1 HOOK protein DivIC PF04977.15 OPL32821.1 - 0.0067 16.2 6.4 0.0067 16.2 6.4 3.1 2 1 1 3 3 3 1 Septum formation initiator Macoilin PF09726.9 OPL32821.1 - 0.011 14.3 16.1 0.016 13.8 16.1 1.1 1 0 0 1 1 1 0 Macoilin family YabA PF06156.13 OPL32821.1 - 0.11 13.1 18.2 0.039 14.6 5.0 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Prominin PF05478.11 OPL32821.1 - 0.12 10.3 6.4 0.19 9.7 6.4 1.3 1 0 0 1 1 1 0 Prominin PIN_8 PF18476.1 OPL32821.1 - 0.15 11.9 17.6 0.043 13.7 8.7 3.3 3 1 0 4 4 4 0 PIN like domain AAA_13 PF13166.6 OPL32821.1 - 0.21 10.2 14.0 0.37 9.4 14.0 1.3 1 0 0 1 1 1 0 AAA domain GAS PF13851.6 OPL32821.1 - 0.22 10.8 28.7 0.018 14.4 23.8 1.6 2 0 0 2 2 1 0 Growth-arrest specific micro-tubule binding RP-C_C PF11800.8 OPL32821.1 - 0.58 10.2 7.4 1.6 8.8 6.3 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF719 PF05334.13 OPL32821.1 - 0.65 10.2 13.3 0.35 11.0 11.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF719) Cnn_1N PF07989.11 OPL32821.1 - 0.73 10.0 22.3 0.15 12.3 8.4 2.9 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Atg14 PF10186.9 OPL32821.1 - 0.74 8.8 26.6 1.1 8.3 22.5 2.6 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.22 OPL32821.1 - 0.82 9.9 23.7 3.4 7.9 21.8 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Mod_r PF07200.13 OPL32821.1 - 0.87 9.7 26.4 0.33 11.1 21.4 2.5 2 1 1 3 3 2 0 Modifier of rudimentary (Mod(r)) protein Baculo_p24 PF05073.12 OPL32821.1 - 1 9.1 10.7 0.44 10.3 7.0 2.0 2 0 0 2 2 2 0 Baculovirus P24 capsid protein DUF1465 PF07323.12 OPL32821.1 - 1.1 9.1 12.0 0.58 10.0 7.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) PHM7_cyt PF14703.6 OPL32821.1 - 1.1 9.4 13.8 0.73 10.0 11.4 1.8 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter HSP70 PF00012.20 OPL32821.1 - 1.2 7.3 12.1 1.9 6.5 12.1 1.3 1 0 0 1 1 1 0 Hsp70 protein AKNA PF12443.8 OPL32821.1 - 1.7 9.3 18.7 0.11 13.1 7.3 2.4 1 1 1 2 2 1 0 AT-hook-containing transcription factor FapA PF03961.13 OPL32821.1 - 1.7 7.1 15.6 0.13 10.9 10.7 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A GAIN_A PF18619.1 OPL32821.1 - 1.8 8.9 6.1 3.6 7.9 1.5 2.7 2 0 0 2 2 2 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A TMCO5 PF14992.6 OPL32821.1 - 1.8 8.1 22.3 0.51 9.9 18.2 1.9 2 0 0 2 2 2 0 TMCO5 family ERM PF00769.19 OPL32821.1 - 2.4 7.9 32.2 3.6 7.3 32.2 1.3 1 1 0 1 1 1 0 Ezrin/radixin/moesin family TMPIT PF07851.13 OPL32821.1 - 2.8 7.1 12.7 5.5 6.1 12.7 1.5 1 0 0 1 1 1 0 TMPIT-like protein FokI_N PF02981.15 OPL32821.1 - 3 8.0 5.1 2.2 8.4 0.6 2.6 2 1 1 3 3 3 0 Restriction endonuclease FokI, recognition domain GNAT_acetyltr_2 PF13718.6 OPL32821.1 - 3.4 7.0 10.1 11 5.3 6.8 2.5 2 1 0 2 2 2 0 GNAT acetyltransferase 2 DUF641 PF04859.12 OPL32821.1 - 3.9 7.8 17.9 4.7 7.6 15.6 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CorA PF01544.18 OPL32821.1 - 3.9 6.7 12.2 2.2 7.5 10.0 1.6 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein 5_nucleotid PF05761.14 OPL32821.1 - 4 6.2 12.9 5 5.9 10.3 2.1 2 0 0 2 2 2 0 5' nucleotidase family PIN_12 PF16289.5 OPL32821.1 - 4 7.9 14.4 5.9 7.4 8.8 3.0 3 0 0 3 3 3 0 PIN domain NPV_P10 PF05531.12 OPL32821.1 - 4.8 7.7 7.6 31 5.1 0.5 2.8 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein GvpL_GvpF PF06386.11 OPL32821.1 - 6.8 6.6 10.3 10 6.0 10.3 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF HemX PF04375.14 OPL32821.1 - 7 5.8 17.7 15 4.8 16.9 1.7 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase PCRF PF03462.18 OPL32821.1 - 7.7 6.3 19.6 1.2 9.0 15.2 1.8 2 0 0 2 2 2 0 PCRF domain Fez1 PF06818.15 OPL32821.1 - 8.6 6.8 27.5 24 5.3 9.0 2.2 1 1 1 2 2 2 0 Fez1 DUF948 PF06103.11 OPL32821.1 - 8.9 6.7 7.4 3.3 8.0 1.4 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Borrelia_P83 PF05262.11 OPL32821.1 - 9.6 4.6 17.6 3.2 6.1 15.1 1.3 2 0 0 2 2 2 0 Borrelia P83/100 protein FOXP-CC PF16159.5 OPL32823.1 - 0.2 12.3 6.3 0.27 11.9 2.9 2.3 1 1 1 2 2 2 0 FOXP coiled-coil domain LPMO_10 PF03067.15 OPL32824.1 - 5.8e-24 85.8 0.2 9e-24 85.2 0.2 1.3 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading TSP_1 PF00090.19 OPL32825.1 - 2.9e-20 72.2 21.6 7.2e-12 45.3 5.5 2.3 2 0 0 2 2 2 2 Thrombospondin type 1 domain EphA2_TM PF14575.6 OPL32825.1 - 0.0047 17.8 0.1 0.014 16.3 0.1 1.8 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Tmemb_9 PF05434.11 OPL32825.1 - 0.015 15.2 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 TMEM9 SKG6 PF08693.10 OPL32825.1 - 0.021 14.2 1.2 0.021 14.2 1.2 1.7 2 0 0 2 2 2 0 Transmembrane alpha-helix domain ODV-E18 PF10717.9 OPL32825.1 - 0.048 13.5 0.0 0.095 12.6 0.0 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Adeno_E3_CR2 PF02439.15 OPL32825.1 - 0.048 13.4 0.2 0.048 13.4 0.2 1.9 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 TRP PF06011.12 OPL32825.1 - 0.08 11.6 0.0 0.095 11.4 0.0 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF2207 PF09972.9 OPL32825.1 - 0.093 11.5 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Comm PF15957.5 OPL32825.1 - 0.13 12.6 0.5 0.24 11.7 0.0 1.7 2 0 0 2 2 2 0 Commissureless Viral_RdRp_C PF17501.2 OPL32825.1 - 1.2 9.6 5.2 1.7 9.2 1.3 2.4 2 0 0 2 2 2 0 Viral RNA-directed RNA polymerase Syndecan PF01034.20 OPL32825.1 - 2.5 8.1 5.5 4.5 7.2 5.4 1.5 1 1 0 1 1 1 0 Syndecan domain FtsA PF14450.6 OPL32828.1 - 0.0067 16.8 0.1 0.0091 16.4 0.1 1.2 1 0 0 1 1 1 1 Cell division protein FtsA FtsQ PF03799.15 OPL32828.1 - 0.011 16.5 0.6 0.015 16.1 0.6 1.2 1 0 0 1 1 1 0 Cell division protein FtsQ RPW8 PF05659.11 OPL32828.1 - 0.02 14.6 4.6 0.028 14.1 4.6 1.3 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Sec2p PF06428.11 OPL32828.1 - 0.17 11.9 6.8 2.5 8.1 0.6 2.3 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p KELK PF15796.5 OPL32828.1 - 0.25 11.8 11.1 0.44 11.0 11.1 1.4 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase TMPIT PF07851.13 OPL32828.1 - 0.62 9.3 5.7 0.71 9.1 5.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 OPL32828.1 - 2.2 8.3 6.7 4.9 7.2 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) fn3 PF00041.21 OPL32829.1 - 4.6e-12 46.1 0.1 1.7e-11 44.3 0.1 2.1 1 0 0 1 1 1 1 Fibronectin type III domain Septin PF00735.18 OPL32829.1 - 1.1e-08 34.7 0.3 2.4e-08 33.6 0.3 1.5 1 0 0 1 1 1 1 Septin Tissue_fac PF01108.17 OPL32829.1 - 1.4e-05 24.9 0.1 5.7e-05 22.9 0.1 2.0 1 0 0 1 1 1 1 Tissue factor MMR_HSR1 PF01926.23 OPL32829.1 - 5.8e-05 23.2 0.0 0.00023 21.2 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 OPL32829.1 - 0.00053 19.6 0.1 0.0013 18.3 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 OPL32829.1 - 0.002 17.8 0.3 0.005 16.6 0.3 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 OPL32829.1 - 0.003 17.7 0.0 0.0081 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 OPL32829.1 - 0.0042 17.0 1.9 0.012 15.6 0.3 2.6 3 1 0 3 3 2 1 RsgA GTPase Mg_chelatase PF01078.21 OPL32829.1 - 0.0047 16.3 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TrwB_AAD_bind PF10412.9 OPL32829.1 - 0.016 14.2 1.4 0.19 10.6 0.1 2.6 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain AAA_23 PF13476.6 OPL32829.1 - 0.018 15.6 10.6 0.33 11.4 0.0 3.1 4 0 0 4 4 2 0 AAA domain TsaE PF02367.17 OPL32829.1 - 0.021 14.8 0.3 0.055 13.5 0.3 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 OPL32829.1 - 0.046 14.2 0.0 0.046 14.2 0.0 2.6 3 0 0 3 3 2 0 ABC transporter PduV-EutP PF10662.9 OPL32829.1 - 0.049 13.4 0.8 0.35 10.6 0.3 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 OPL32829.1 - 0.057 12.9 0.4 0.19 11.2 0.1 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 OPL32829.1 - 0.062 12.4 0.1 0.12 11.4 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 OPL32829.1 - 0.069 12.8 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain FtsK_SpoIIIE PF01580.18 OPL32829.1 - 0.09 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AMP-binding_C_2 PF14535.6 OPL32829.1 - 3 8.2 6.0 0.35 11.2 0.4 2.2 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain VWA_3 PF13768.6 OPL32830.1 - 8.2e-13 48.6 0.0 1.3e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 OPL32830.1 - 1.1e-06 29.0 0.2 1.9e-06 28.2 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Dynein_heavy PF03028.15 OPL32830.1 - 0.093 12.8 0.0 1.8 8.7 0.0 2.2 2 0 0 2 2 2 0 Dynein heavy chain region D6 P-loop domain TGF_beta PF00019.20 OPL32831.1 - 1.9e-23 83.4 7.0 4.7e-23 82.1 2.2 2.2 1 1 1 2 2 2 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 OPL32831.1 - 6.5e-07 29.3 0.3 9.2e-07 28.8 0.3 1.2 1 0 0 1 1 1 1 TGF-beta propeptide DUF5319 PF17252.2 OPL32831.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5319) Imm17 PF15562.6 OPL32831.1 - 0.17 11.7 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 17 MFS_1 PF07690.16 OPL32832.1 - 1.1e-30 106.8 24.7 5.2e-23 81.5 12.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_U4 PF03419.13 OPL32832.1 - 2.2e-05 23.9 1.0 2.2e-05 23.9 1.0 2.3 2 1 0 2 2 2 1 Sporulation factor SpoIIGA SBF PF01758.16 OPL32832.1 - 0.84 9.3 7.8 0.052 13.2 2.6 1.7 2 0 0 2 2 2 0 Sodium Bile acid symporter family Fibrinogen_C PF00147.18 OPL32833.1 - 4.1e-13 49.6 0.3 4.1e-13 49.6 0.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Prok-RING_4 PF14447.6 OPL32834.1 - 0.04 13.8 2.3 0.04 13.8 2.3 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 Glyco_transf_10 PF00852.19 OPL32834.1 - 1.5 8.5 7.0 7.1 6.3 0.1 2.8 3 0 0 3 3 3 0 Glycosyltransferase family 10 (fucosyltransferase) C-term DNA_pol_B_palm PF14792.6 OPL32835.1 - 2.3e-34 118.0 0.0 5.4e-34 116.8 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 OPL32835.1 - 1.8e-22 78.9 0.1 1.6e-20 72.6 0.0 2.4 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 OPL32835.1 - 1.6e-16 60.4 3.2 3.8e-14 52.8 0.8 3.2 3 1 1 4 4 4 2 Helix-hairpin-helix domain HHH_5 PF14520.6 OPL32835.1 - 7.8e-09 36.0 0.2 1.5e-05 25.5 0.0 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix domain Cdd1 PF11731.8 OPL32835.1 - 2e-05 24.8 0.4 0.013 15.7 0.0 3.2 1 1 2 3 3 3 1 Pathogenicity locus HHH PF00633.23 OPL32835.1 - 0.0021 17.9 0.2 0.55 10.2 0.0 2.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif NTP_transf_2 PF01909.23 OPL32835.1 - 0.0039 17.4 0.0 0.0083 16.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_2 PF12826.7 OPL32835.1 - 0.0046 17.0 0.5 0.25 11.5 0.1 3.0 2 1 1 3 3 3 1 Helix-hairpin-helix motif HHH_3 PF12836.7 OPL32835.1 - 0.022 15.0 0.4 1.4 9.2 0.1 2.9 1 1 1 2 2 2 0 Helix-hairpin-helix motif 5_3_exonuc PF01367.20 OPL32835.1 - 0.026 15.1 2.5 0.094 13.3 0.1 2.5 1 1 1 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold PAPS_reduct PF01507.19 OPL32836.1 - 4.7e-20 72.3 0.4 9.7e-19 68.1 0.1 2.0 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family AhpC-TSA PF00578.21 OPL32837.1 - 0.015 15.3 0.1 0.027 14.4 0.1 1.4 1 0 0 1 1 1 0 AhpC/TSA family PIRT PF15099.6 OPL32838.1 - 0.0029 17.2 0.0 0.0044 16.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family DUF3377 PF11857.8 OPL32838.1 - 0.096 12.6 4.3 0.32 11.0 4.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3377) DUF4448 PF14610.6 OPL32838.1 - 0.1 12.4 0.2 0.2 11.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF2613 PF11021.8 OPL32842.1 - 0.067 13.3 0.1 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) MacB_PCD PF12704.7 OPL32842.1 - 0.13 12.6 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 MacB-like periplasmic core domain TRAM PF01938.20 OPL32842.1 - 0.59 10.2 2.3 32 4.6 0.7 3.1 1 1 1 2 2 2 0 TRAM domain Glyco_transf_7N PF13733.6 OPL32843.1 - 4.3e-45 152.6 0.5 5.7e-45 152.2 0.5 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 BRF1 PF07741.13 OPL32844.1 - 0.024 15.0 7.0 0.037 14.4 7.0 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Ribosomal_L50 PF10501.9 OPL32844.1 - 0.037 14.2 2.3 0.051 13.7 0.3 2.2 1 1 2 3 3 3 0 Ribosomal subunit 39S TPP_enzyme_C PF02775.21 OPL32846.1 - 9.6e-23 80.7 0.1 1.2e-22 80.3 0.1 1.1 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.10 OPL32846.1 - 0.087 11.6 0.1 0.3 9.9 0.0 1.7 2 0 0 2 2 2 0 XFP N-terminal domain Gelsolin PF00626.22 OPL32847.1 - 7.8e-20 70.6 0.0 1.4e-09 37.7 0.0 2.4 2 0 0 2 2 2 2 Gelsolin repeat PIRT PF15099.6 OPL32847.1 - 0.035 13.7 0.1 0.47 10.0 0.0 2.1 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family Vps53_N PF04100.12 OPL32848.1 - 0.014 14.4 0.1 0.016 14.2 0.1 1.0 1 0 0 1 1 1 0 Vps53-like, N-terminal Lectin_C PF00059.21 OPL32849.1 - 3.5e-05 24.5 0.1 3.5e-05 24.5 0.1 1.2 1 1 0 1 1 1 1 Lectin C-type domain Imm27 PF15590.6 OPL32849.1 - 0.12 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 27 Fibrinogen_C PF00147.18 OPL32851.1 - 1.7e-34 119.6 6.0 5.4e-34 117.9 1.2 2.5 2 1 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain Apolipoprotein PF01442.18 OPL32851.1 - 0.2 11.5 24.3 8.1 6.3 17.9 3.2 1 1 1 3 3 3 0 Apolipoprotein A1/A4/E domain Fibin PF15819.5 OPL32851.1 - 2.9 7.6 23.9 3.7 7.3 1.3 3.7 1 1 1 3 3 3 0 Fin bud initiation factor homologue Sec3_C_2 PF15278.6 OPL32851.1 - 7.8 6.9 24.9 6.9 7.1 0.2 5.4 3 1 2 6 6 6 0 Sec3 exocyst complex subunit Phasin PF05597.11 OPL32851.1 - 8.7 6.4 26.8 6.7 6.7 1.6 4.9 1 1 3 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF1310 PF07006.11 OPL32852.1 - 0.012 15.5 1.2 0.22 11.5 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1310) Spore_II_R PF09551.10 OPL32852.1 - 0.91 10.0 5.8 0.4 11.1 2.4 2.0 2 1 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) Lectin_C PF00059.21 OPL32853.1 - 2e-05 25.3 0.0 3.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain PTR2 PF00854.21 OPL32855.1 - 2.1e-31 109.1 6.0 1.9e-12 46.8 0.4 3.8 3 1 1 4 4 4 3 POT family DTC PF18102.1 OPL32856.1 - 3.9e-31 107.9 0.1 1e-30 106.6 0.0 1.8 2 0 0 2 2 2 1 Deltex C-terminal domain zf-C3HC4_2 PF13923.6 OPL32856.1 - 2e-09 37.1 13.6 4.2e-09 36.1 13.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL32856.1 - 8.1e-09 35.7 11.4 1.8e-08 34.5 11.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 OPL32856.1 - 2.6e-07 30.4 12.8 5.6e-07 29.3 12.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 OPL32856.1 - 2.2e-06 27.6 5.7 2.2e-06 27.6 5.7 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 OPL32856.1 - 3.1e-06 26.9 8.7 5.2e-06 26.2 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 OPL32856.1 - 3.9e-06 26.7 10.2 7.5e-06 25.8 10.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 OPL32856.1 - 6.6e-06 25.9 5.1 1.7e-05 24.6 5.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 OPL32856.1 - 8.3e-05 22.4 6.2 0.00019 21.2 5.7 1.9 2 0 0 2 2 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 OPL32856.1 - 9e-05 22.5 7.3 0.00024 21.2 7.3 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 Macro PF01661.21 OPL32856.1 - 0.00022 21.2 0.3 0.00066 19.7 0.0 1.8 2 0 0 2 2 2 1 Macro domain Prok-RING_4 PF14447.6 OPL32856.1 - 0.0016 18.3 10.4 0.0031 17.3 10.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 OPL32856.1 - 0.0025 18.1 5.9 0.0025 18.1 5.9 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger domain VHS PF00790.19 OPL32856.1 - 0.022 14.6 0.0 0.059 13.2 0.0 1.7 1 0 0 1 1 1 0 VHS domain zf-C3HC4_4 PF15227.6 OPL32856.1 - 0.091 12.9 13.4 0.24 11.6 13.4 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING GCR1_C PF12550.8 OPL32856.1 - 0.49 10.8 2.4 18 5.7 0.0 3.1 2 1 0 2 2 2 0 Transcriptional activator of glycolytic enzymes zf-RING_4 PF14570.6 OPL32856.1 - 1.6 8.6 8.6 3.7 7.4 8.6 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 OPL32856.1 - 1.9 8.3 8.3 4.4 7.1 8.3 1.6 1 0 0 1 1 1 0 RING-like zinc finger TSP_1 PF00090.19 OPL32857.1 - 4.8e-18 65.1 68.2 2e-08 34.3 6.6 5.2 4 2 0 4 4 4 4 Thrombospondin type 1 domain CCDC14 PF15254.6 OPL32858.1 - 8.4e-20 71.1 16.7 2.2e-19 69.7 16.7 1.6 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 14 TSP_1 PF00090.19 OPL32859.1 - 1.7e-05 24.9 8.1 1.7e-05 24.9 8.1 2.5 2 1 0 2 2 2 1 Thrombospondin type 1 domain Paf67 PF10255.9 OPL32860.1 - 2.2e-146 488.0 6.2 3.5e-146 487.4 6.2 1.2 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 ANAPC3 PF12895.7 OPL32860.1 - 0.0095 16.1 0.6 0.12 12.6 0.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 OPL32860.1 - 0.013 15.3 0.0 0.43 10.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 OPL32860.1 - 0.019 15.1 0.1 0.37 11.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 OPL32860.1 - 0.034 14.4 0.0 2.2 8.6 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2428 PF10350.9 OPL32860.1 - 0.09 12.0 0.9 27 3.9 0.0 3.0 2 1 1 3 3 3 0 Putative death-receptor fusion protein (DUF2428) TPR_19 PF14559.6 OPL32860.1 - 0.097 13.2 0.2 0.61 10.6 0.0 2.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 OPL32860.1 - 0.16 12.7 0.5 3.7 8.4 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat adh_short_C2 PF13561.6 OPL32861.1 - 3.6e-48 164.2 0.0 1e-31 110.4 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 OPL32861.1 - 1.3e-46 158.5 0.4 2.7e-25 89.0 0.0 2.0 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 OPL32861.1 - 7e-09 35.8 0.0 3.5e-07 30.3 0.0 2.2 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 OPL32861.1 - 1e-05 25.1 0.0 0.00012 21.6 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 OPL32861.1 - 0.0019 17.4 0.0 0.003 16.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 OPL32861.1 - 0.0042 17.0 0.0 0.0064 16.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 OPL32861.1 - 0.016 15.2 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 OPL32861.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Rdx PF10262.9 OPL32861.1 - 0.18 12.0 0.0 0.27 11.5 0.0 1.6 1 1 0 1 1 1 0 Rdx family SWIM PF04434.17 OPL32863.1 - 0.0026 17.4 3.2 0.0061 16.2 3.2 1.6 1 0 0 1 1 1 1 SWIM zinc finger Ish1 PF10281.9 OPL32863.1 - 2.9 8.3 0.0 2.9 8.3 0.0 2.8 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein DNA_RNApol_7kD PF03604.13 OPL32865.1 - 0.039 13.6 0.1 0.072 12.8 0.1 1.4 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Ribosomal_S27e PF01667.17 OPL32865.1 - 0.08 12.7 0.3 0.14 11.9 0.3 1.3 1 0 0 1 1 1 0 Ribosomal protein S27 Baculo_PEP_C PF04513.12 OPL32866.1 - 6.7e-05 23.0 16.7 0.062 13.3 0.2 4.7 2 2 3 5 5 5 3 Baculovirus polyhedron envelope protein, PEP, C terminus Helo_like_N PF17111.5 OPL32866.1 - 0.01 15.3 0.3 0.01 15.3 0.3 3.5 1 1 0 3 3 3 1 Fungal N-terminal domain of STAND proteins DUF1664 PF07889.12 OPL32866.1 - 0.051 13.6 21.8 0.056 13.5 0.8 4.6 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 OPL32866.1 - 0.11 12.7 20.9 1.6 8.9 5.2 4.0 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family DUF3724 PF12521.8 OPL32866.1 - 0.16 12.0 0.0 0.43 10.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3724) Apolipoprotein PF01442.18 OPL32866.1 - 0.16 11.8 17.3 0.57 10.0 3.2 3.4 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF842 PF05811.13 OPL32866.1 - 0.23 11.2 8.2 9.6 5.9 0.1 3.7 2 1 0 3 3 3 0 Eukaryotic protein of unknown function (DUF842) PEP-utilisers_N PF05524.13 OPL32866.1 - 0.35 11.1 12.6 5.2 7.3 0.1 4.0 2 2 1 3 3 3 0 PEP-utilising enzyme, N-terminal DUF3213 PF11491.8 OPL32866.1 - 0.35 11.1 2.6 0.32 11.2 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3213) DUF5082 PF16888.5 OPL32866.1 - 0.78 10.0 18.8 4 7.7 3.0 4.3 3 2 1 4 4 4 0 Domain of unknown function (DUF5082) Phasin PF05597.11 OPL32866.1 - 2 8.4 16.2 0.88 9.6 0.2 4.4 3 2 2 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) PRKCSH PF07915.13 OPL32867.1 - 6e-09 36.8 4.1 6e-09 36.8 4.1 2.5 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 OPL32867.1 - 1.4e-08 34.6 1.6 2.9e-08 33.5 1.6 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein EF-hand_1 PF00036.32 OPL32867.1 - 7.9e-05 21.9 2.7 0.19 11.4 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 OPL32867.1 - 0.0002 20.7 2.3 0.015 14.7 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 OPL32867.1 - 0.00045 19.9 0.8 0.15 12.0 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 OPL32867.1 - 0.00084 19.7 0.3 0.15 12.5 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain pair DUSP PF06337.12 OPL32867.1 - 0.004 17.7 1.1 0.14 12.8 0.1 2.3 2 0 0 2 2 2 1 DUSP domain MIEAP PF16026.5 OPL32868.1 - 1.5e-05 25.3 0.0 3.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Mitochondria-eating protein PKcGMP_CC PF16808.5 OPL32868.1 - 0.074 12.9 0.8 0.79 9.6 0.8 2.5 1 1 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MPS2 PF17060.5 OPL32868.1 - 1.3 8.2 5.8 2 7.6 0.1 2.3 1 1 1 2 2 2 0 Monopolar spindle protein 2 PhyH PF05721.13 OPL32869.1 - 1.6e-14 54.6 0.0 3.1e-14 53.7 0.0 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Lamp PF01299.17 OPL32870.1 - 4.2e-21 75.3 3.1 3.2e-18 66.0 0.3 2.2 2 0 0 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 OPL32870.1 - 1.9e-06 27.8 7.3 0.005 16.7 0.4 3.1 2 1 0 3 3 3 2 Vacuolar ATP synthase subunit S1 (ATP6S1) AAA_34 PF13872.6 OPL32871.1 - 2.6e-94 315.5 0.0 3.8e-94 315.0 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 OPL32871.1 - 1.3e-86 290.7 0.6 2.2e-86 289.9 0.6 1.4 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue Helicase_C PF00271.31 OPL32871.1 - 0.0015 18.8 0.0 0.0066 16.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 OPL32871.1 - 0.0034 17.4 0.0 0.0034 17.4 0.0 2.3 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit Tropomodulin PF03250.14 OPL32871.1 - 0.034 14.2 0.9 0.034 14.2 0.9 2.1 2 0 0 2 2 2 0 Tropomodulin zf-NOSIP PF15906.5 OPL32871.1 - 0.053 13.7 0.4 3 8.0 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein SR-25 PF10500.9 OPL32871.1 - 0.14 11.8 22.5 0.35 10.5 22.5 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MecA PF05389.12 OPL32871.1 - 0.16 11.6 5.1 1.6 8.3 0.2 2.4 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF4692 PF15763.5 OPL32871.1 - 2.1 8.8 5.9 5.7 7.4 5.9 1.7 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Smg8_Smg9 PF10220.9 OPL32871.1 - 4.8 5.4 7.3 6.7 4.9 7.3 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Proteasome PF00227.26 OPL32874.1 - 3.3e-10 39.8 0.0 3.9e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Roc PF08477.13 OPL32875.1 - 2.6e-11 43.8 0.3 1.1e-07 32.0 0.1 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 OPL32875.1 - 0.003 18.1 0.4 0.0069 16.9 0.4 1.7 1 1 0 1 1 1 1 ABC transporter Presenilin PF01080.17 OPL32875.1 - 0.038 12.7 1.3 0.046 12.5 1.3 1.1 1 0 0 1 1 1 0 Presenilin Ras PF00071.22 OPL32875.1 - 0.063 12.9 0.4 3.5 7.2 0.1 2.2 2 0 0 2 2 2 0 Ras family NTPase_1 PF03266.15 OPL32875.1 - 0.13 12.2 0.4 0.22 11.4 0.0 1.6 2 0 0 2 2 2 0 NTPase AAA_16 PF13191.6 OPL32875.1 - 0.13 12.6 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain HD PF01966.22 OPL32876.1 - 2.6e-06 27.6 1.0 5.7e-06 26.6 1.0 1.8 1 1 0 1 1 1 1 HD domain PDEase_I PF00233.19 OPL32876.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase CNTF PF01110.17 OPL32876.1 - 0.076 12.4 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Ciliary neurotrophic factor CENP-B_dimeris PF09026.10 OPL32876.1 - 1 9.8 7.9 1.6 9.2 7.9 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BROMI PF14961.6 OPL32877.1 - 2.2e-05 22.1 0.0 2.3e-05 22.1 0.0 1.0 1 0 0 1 1 1 1 Broad-minded protein BROMI PF14961.6 OPL32878.1 - 2.3e-20 71.8 1.1 2.6e-20 71.6 1.1 1.0 1 0 0 1 1 1 1 Broad-minded protein DUF4806 PF16064.5 OPL32878.1 - 0.027 14.8 0.6 0.19 12.0 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4806) bZIP_1 PF00170.21 OPL32880.1 - 5.3e-18 64.9 15.2 9.7e-18 64.0 15.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.17 OPL32880.1 - 1e-14 53.7 1.7 1e-14 53.7 1.7 2.0 2 0 0 2 2 2 1 pKID domain bZIP_2 PF07716.15 OPL32880.1 - 2e-07 31.0 13.1 4.6e-07 29.8 13.1 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 OPL32880.1 - 0.0045 17.5 4.6 0.01 16.3 4.6 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor ig PF00047.25 OPL32881.1 - 8.5e-06 25.9 4.2 2e-05 24.7 0.5 2.2 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 OPL32881.1 - 1.2e-05 25.3 0.4 1.2e-05 25.3 0.4 1.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 OPL32881.1 - 0.00027 21.1 2.8 0.00028 21.0 0.6 2.0 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 OPL32881.1 - 0.00082 19.9 2.7 0.0011 19.5 0.2 2.1 2 0 0 2 2 2 1 Immunoglobulin domain zf-RRN7 PF11781.8 OPL32881.1 - 0.016 14.9 1.1 0.16 11.7 0.1 2.6 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Xrn1_D3 PF18194.1 OPL32881.1 - 0.033 14.3 0.2 1.5 9.0 0.0 2.3 1 1 1 2 2 2 0 Exoribonuclease 1 Domain-3 A2M_recep PF07677.14 OPL32881.1 - 0.21 12.3 1.9 11 6.8 0.2 2.3 2 0 0 2 2 2 0 A-macroglobulin receptor binding domain HEAT PF02985.22 OPL32882.1 - 0.00023 21.2 0.1 0.0018 18.3 0.0 2.5 2 0 0 2 2 2 1 HEAT repeat TIR_2 PF13676.6 OPL32884.1 - 2.5e-23 82.9 0.0 4.1e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 OPL32884.1 - 0.0035 17.2 0.1 0.0083 15.9 0.0 1.7 2 0 0 2 2 2 1 TIR domain TIR-like PF10137.9 OPL32884.1 - 0.13 12.2 0.0 0.77 9.7 0.0 2.1 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain ssDBP PF17878.1 OPL32884.1 - 0.17 12.2 0.2 0.33 11.2 0.2 1.4 1 0 0 1 1 1 0 Single-stranded DNA-binding protein IgGFc_binding PF17517.2 OPL32885.1 - 6.9e-33 114.2 4.1 6.9e-33 114.2 4.1 1.8 2 0 0 2 2 2 1 IgGFc binding protein EB PF01683.18 OPL32885.1 - 5.7 7.3 28.4 0.22 11.9 10.0 2.7 1 1 1 2 2 2 0 EB module WSC PF01822.19 OPL32886.1 - 2.1e-06 27.8 6.6 4.3e-06 26.8 6.6 1.6 1 0 0 1 1 1 1 WSC domain Phage_cap_P2 PF05125.12 OPL32886.1 - 0.18 10.7 0.4 0.27 10.2 0.4 1.2 1 0 0 1 1 1 0 Phage major capsid protein, P2 family HCO3_cotransp PF00955.21 OPL32887.1 - 5.6e-27 94.7 7.2 7.2e-27 94.4 7.2 1.1 1 0 0 1 1 1 1 HCO3- transporter family DUF229 PF02995.17 OPL32888.1 - 1.3e-48 165.9 5.1 1.3e-48 165.9 5.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF229) CC2-LZ PF16516.5 OPL32888.1 - 0.0077 16.6 13.7 0.0077 16.6 13.7 3.0 3 1 0 3 3 3 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF1011 PF06237.12 OPL32888.1 - 0.11 12.8 0.3 0.56 10.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) KELK PF15796.5 OPL32888.1 - 0.35 11.4 48.9 0.67 10.5 9.4 4.5 1 1 3 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Cas6b_C PF17262.2 OPL32888.1 - 1 9.5 9.3 5 7.3 3.6 3.0 1 1 1 2 2 2 0 Cas6b C-terminal domain TMF_TATA_bd PF12325.8 OPL32888.1 - 2.1 8.6 37.8 1.2 9.4 23.6 3.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding HAP1_N PF04849.13 OPL32888.1 - 4.4 6.4 44.4 0.54 9.4 38.0 2.5 1 1 0 1 1 1 0 HAP1 N-terminal conserved region VCBS PF13517.6 OPL32889.1 - 1.1e-05 25.9 1.7 3.2e-05 24.4 1.3 2.1 1 1 1 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 OPL32889.1 - 2.5e-05 24.3 0.7 2.5e-05 24.3 0.7 2.1 2 0 0 2 2 2 1 FG-GAP repeat PliI PF16743.5 OPL32889.1 - 0.025 14.3 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Periplasmic lysozyme inhibitor of I-type lysozyme MAM PF00629.23 OPL32890.1 - 3e-12 46.8 1.4 3.9e-12 46.4 0.0 1.8 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu Trypan_PARP PF05887.11 OPL32890.1 - 1.4 8.9 31.5 10 6.1 31.4 2.0 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MAM PF00629.23 OPL32891.1 - 1.3e-18 67.4 4.7 3.6e-09 36.7 0.8 3.5 3 1 0 3 3 3 2 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.18 OPL32891.1 - 1.3e-08 34.9 13.2 1.3e-08 34.9 13.2 2.0 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Interfer-bind PF09294.10 OPL32891.1 - 0.062 13.6 0.2 0.3 11.4 0.0 2.2 2 1 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III Med3 PF11593.8 OPL32892.1 - 0.011 15.0 2.2 0.014 14.6 2.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF812 PF05667.11 OPL32892.1 - 0.03 13.2 27.6 0.037 12.9 27.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Spc7 PF08317.11 OPL32892.1 - 2.4 7.0 32.4 0.16 10.8 24.3 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein TMPIT PF07851.13 OPL32892.1 - 3.4 6.8 20.3 0.18 11.0 11.9 2.1 1 1 1 2 2 2 0 TMPIT-like protein Lectin_C PF00059.21 OPL32893.1 - 2.2e-17 63.7 4.4 2.2e-17 63.7 4.4 1.6 1 1 1 2 2 2 1 Lectin C-type domain Fzo_mitofusin PF04799.13 OPL32893.1 - 0.051 13.1 0.1 0.076 12.6 0.1 1.2 1 0 0 1 1 1 0 fzo-like conserved region Baculo_PEP_C PF04513.12 OPL32893.1 - 0.096 12.7 0.2 0.14 12.2 0.2 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus LRAT PF04970.13 OPL32894.1 - 0.00027 21.2 0.2 0.35 11.2 0.1 2.5 2 1 0 2 2 2 2 Lecithin retinol acyltransferase CDC48_2 PF02933.17 OPL32894.1 - 0.092 12.5 0.1 3.7 7.4 0.0 2.6 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 Cu_bind_like PF02298.17 OPL32894.1 - 0.44 10.6 1.9 1.9 8.6 0.0 2.8 2 1 0 3 3 3 0 Plastocyanin-like domain DnaJ PF00226.31 OPL32895.1 - 3.4e-26 91.2 1.3 4.9e-26 90.6 1.3 1.2 1 0 0 1 1 1 1 DnaJ domain DUF3810 PF12725.7 OPL32895.1 - 0.018 14.4 0.3 0.018 14.4 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DUF5411 PF17424.2 OPL32897.1 - 0.053 13.5 0.3 0.069 13.1 0.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5411) SP_C-Propep PF08999.10 OPL32898.1 - 0.12 12.1 1.3 0.2 11.4 1.3 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide OSTbeta PF15048.6 OPL32898.1 - 0.13 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF4834 PF16118.5 OPL32898.1 - 0.87 10.6 6.2 5.2 8.1 6.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Macro PF01661.21 OPL32900.1 - 9.6e-08 32.1 0.0 2.4e-07 30.8 0.0 1.7 2 1 0 2 2 2 1 Macro domain Spermine_synth PF01564.17 OPL32900.1 - 0.084 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Spermine/spermidine synthase domain A_amylase_inhib PF01356.19 OPL32900.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Alpha amylase inhibitor VitD-bind_III PF09164.10 OPL32901.1 - 0.12 12.3 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Vitamin D binding protein, domain III MIP PF00230.20 OPL32902.1 - 2.3e-49 168.1 15.3 3.8e-49 167.4 15.3 1.3 1 1 0 1 1 1 1 Major intrinsic protein adh_short PF00106.25 OPL32903.1 - 5.1e-13 48.9 0.7 6.3e-13 48.6 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL32903.1 - 4.5e-07 29.7 0.4 5.1e-07 29.5 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 OPL32903.1 - 3.5e-06 27.1 0.2 4.3e-06 26.7 0.2 1.1 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 OPL32903.1 - 0.00015 21.8 0.2 0.00019 21.5 0.2 1.1 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 OPL32903.1 - 0.0014 18.1 0.1 0.0016 17.8 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 OPL32903.1 - 0.0014 18.9 0.4 0.0018 18.5 0.4 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 OPL32903.1 - 0.0068 15.6 0.1 0.0081 15.3 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 OPL32903.1 - 0.0068 16.3 0.1 0.0082 16.0 0.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 OPL32903.1 - 0.015 14.8 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 OPL32903.1 - 0.022 14.1 0.1 0.028 13.7 0.1 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TIR_2 PF13676.6 OPL32903.1 - 0.025 15.2 0.0 0.034 14.8 0.0 1.2 1 0 0 1 1 1 0 TIR domain ThiF PF00899.21 OPL32903.1 - 0.029 13.7 0.1 0.044 13.1 0.1 1.3 1 0 0 1 1 1 0 ThiF family IlvN PF07991.12 OPL32903.1 - 0.038 13.6 0.2 0.051 13.1 0.2 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 OPL32903.1 - 0.044 14.4 0.2 0.062 13.9 0.2 1.3 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TRAM PF01938.20 OPL32903.1 - 0.049 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 TRAM domain RmlD_sub_bind PF04321.17 OPL32903.1 - 0.11 11.6 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain Glyco_tran_WecB PF03808.13 OPL32903.1 - 0.13 12.2 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family SEA PF01390.20 OPL32905.1 - 0.00051 20.1 0.2 0.0014 18.7 0.2 1.7 2 0 0 2 2 2 1 SEA domain mRNA_decap_C PF16741.5 OPL32905.1 - 0.063 12.6 0.0 0.15 11.3 0.0 1.7 1 0 0 1 1 1 0 mRNA-decapping enzyme C-terminus SAM_PNT PF02198.16 OPL32906.1 - 0.074 13.0 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Ank_4 PF13637.6 OPL32907.1 - 1.9e-21 76.1 0.0 7.2e-10 39.2 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL32907.1 - 9.6e-21 74.2 0.0 3.3e-13 50.0 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 OPL32907.1 - 4.9e-19 68.1 0.1 1.7e-09 37.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 OPL32907.1 - 2.5e-16 59.3 0.1 2.3e-06 27.8 0.0 3.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 OPL32907.1 - 8.9e-14 50.3 0.0 0.00017 21.7 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ldh_2 PF02615.14 OPL32908.1 - 8.6e-67 225.6 0.1 1.1e-66 225.3 0.1 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Herpes_gE PF02480.16 OPL32908.1 - 0.12 11.1 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E zf-B_box PF00643.24 OPL32909.1 - 3.2e-05 24.0 4.9 3.2e-05 24.0 4.9 1.8 3 0 0 3 3 3 1 B-box zinc finger DUF2583 PF10762.9 OPL32911.1 - 0.18 12.3 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2583) DUF1128 PF06569.11 OPL32912.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) AAA_30 PF13604.6 OPL32915.1 - 0.036 13.8 0.0 0.75 9.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain TFIIA PF03153.13 OPL32915.1 - 0.28 11.1 7.9 0.34 10.8 7.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit S_100 PF01023.19 OPL32916.1 - 0.74 9.6 3.3 0.33 10.7 0.4 2.0 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain BIR PF00653.21 OPL32917.1 - 1.5e-19 70.4 0.3 1.5e-19 70.4 0.3 2.0 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 OPL32917.1 - 1.6e-12 47.0 5.6 1.6e-12 47.0 5.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL32917.1 - 2.9e-05 23.8 6.5 2.9e-05 23.8 6.5 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 OPL32917.1 - 0.0058 16.9 8.5 0.0058 16.9 8.5 1.9 2 0 0 2 2 2 1 Ring finger domain Methyltransf_23 PF13489.6 OPL32917.1 - 0.025 14.4 0.1 18 5.1 0.1 3.0 1 1 2 3 3 3 0 Methyltransferase domain WIYLD PF10440.9 OPL32917.1 - 0.033 14.0 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-binding WIYLD domain DUF3843 PF12954.7 OPL32917.1 - 0.054 12.5 0.9 0.11 11.4 0.3 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3843) zf-RING_5 PF14634.6 OPL32917.1 - 0.11 12.5 8.6 0.066 13.2 6.0 2.1 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 OPL32917.1 - 3.1 7.9 6.8 8.6 6.5 6.8 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Tropomyosin_1 PF12718.7 OPL32918.1 - 0.002 18.3 10.7 0.002 18.3 10.7 3.0 2 1 1 3 3 3 2 Tropomyosin like ATG16 PF08614.11 OPL32918.1 - 0.0038 17.5 5.3 0.0038 17.5 5.3 2.5 1 1 0 2 2 2 1 Autophagy protein 16 (ATG16) APG6_N PF17675.1 OPL32918.1 - 0.014 15.9 1.4 0.014 15.9 1.4 3.1 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF2205 PF10224.9 OPL32918.1 - 0.042 13.8 0.4 0.042 13.8 0.4 3.6 3 1 1 4 4 4 0 Short coiled-coil protein Get5_C PF18514.1 OPL32918.1 - 0.045 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Get5 C-terminal domain Cnn_1N PF07989.11 OPL32918.1 - 0.33 11.2 24.4 0.032 14.4 12.7 3.5 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 OPL32918.1 - 0.62 10.2 17.9 0.84 9.8 1.3 4.1 4 0 0 4 4 4 0 bZIP transcription factor PI3K_P85_iSH2 PF16454.5 OPL32918.1 - 0.82 9.3 27.9 2.5 7.7 15.1 3.9 2 1 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4200 PF13863.6 OPL32918.1 - 0.97 9.8 26.6 0.094 13.1 10.8 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) ZapB PF06005.12 OPL32918.1 - 1.1 9.8 33.4 7.6 7.1 15.4 4.1 1 1 0 2 2 2 0 Cell division protein ZapB bZIP_2 PF07716.15 OPL32918.1 - 1.3 9.2 28.2 0.53 10.4 1.0 4.5 5 0 0 5 5 5 0 Basic region leucine zipper FlaC_arch PF05377.11 OPL32918.1 - 2.1 8.8 15.6 22 5.5 0.4 4.3 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.11 OPL32918.1 - 2.2 8.9 15.6 14 6.3 1.8 3.7 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF4407 PF14362.6 OPL32918.1 - 2.4 7.4 18.8 2.6 7.3 0.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) OmpH PF03938.14 OPL32918.1 - 2.5 8.4 28.3 0.25 11.7 10.7 2.5 1 1 0 2 2 2 0 Outer membrane protein (OmpH-like) ShK PF01549.24 OPL32919.1 - 0.00044 20.7 9.4 0.00044 20.7 9.4 1.6 2 0 0 2 2 2 1 ShK domain-like VWC PF00093.18 OPL32920.1 - 0.0001 22.5 16.5 0.0001 22.5 16.5 2.3 2 1 0 2 2 2 1 von Willebrand factor type C domain ShK PF01549.24 OPL32920.1 - 0.0011 19.5 9.8 0.0011 19.5 9.8 3.1 2 1 0 2 2 2 1 ShK domain-like VWC PF00093.18 OPL32921.1 - 7.8e-06 26.1 9.7 1.1e-05 25.7 9.7 1.2 1 0 0 1 1 1 1 von Willebrand factor type C domain VWC PF00093.18 OPL32922.1 - 0.00016 21.9 14.5 0.00023 21.4 14.5 1.3 1 0 0 1 1 1 1 von Willebrand factor type C domain Ig_3 PF13927.6 OPL32923.1 - 0.0036 17.9 0.1 0.011 16.3 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin domain zf-B_box PF00643.24 OPL32924.1 - 5.3e-13 48.9 24.6 8.5e-11 41.8 6.9 2.6 3 0 0 3 3 3 2 B-box zinc finger HsbA PF12296.8 OPL32924.1 - 4.6e-05 23.8 2.6 8.8e-05 22.9 2.7 1.4 1 1 0 1 1 1 1 Hydrophobic surface binding protein A Syntaxin_2 PF14523.6 OPL32924.1 - 0.0025 18.1 9.0 0.0075 16.6 9.0 1.8 1 1 0 1 1 1 1 Syntaxin-like protein Lipase_chap PF03280.14 OPL32924.1 - 0.016 15.2 1.3 0.023 14.7 1.3 1.4 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein Spectrin PF00435.21 OPL32924.1 - 0.017 15.6 4.0 0.017 15.6 4.0 2.4 1 1 0 2 2 2 0 Spectrin repeat CEBP_ZZ PF16366.5 OPL32924.1 - 0.041 14.1 19.9 0.13 12.5 3.5 3.5 3 0 0 3 3 3 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Apolipoprotein PF01442.18 OPL32924.1 - 0.043 13.7 3.2 0.098 12.5 3.1 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Fungal_TACC PF12709.7 OPL32924.1 - 0.056 13.9 0.9 0.056 13.9 0.9 2.8 1 1 2 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Phasin PF05597.11 OPL32924.1 - 0.2 11.7 3.4 0.45 10.5 2.5 2.0 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Phage_Mu_Gam PF07352.12 OPL32924.1 - 0.9 9.4 10.6 0.5 10.3 2.7 3.1 1 1 2 3 3 3 0 Bacteriophage Mu Gam like protein Adhesin_P1_N PF18652.1 OPL32924.1 - 1.1 9.3 8.7 1.6 8.8 1.9 2.7 2 1 1 3 3 3 0 Adhesin P1 N-terminal domain Baculo_PEP_C PF04513.12 OPL32924.1 - 1.5 8.9 7.9 2 8.5 3.0 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Peptidase_C1 PF00112.23 OPL32925.1 - 1.7e-23 83.8 0.1 2.6e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 OPL32925.1 - 6.7e-13 48.9 0.2 1e-12 48.3 0.2 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) ApeC PF16977.5 OPL32926.1 - 6.1e-63 212.5 11.4 7.1e-63 212.3 11.4 1.0 1 0 0 1 1 1 1 C-terminal domain of apextrin DnaJ PF00226.31 OPL32927.1 - 3.9e-19 68.5 0.0 8.6e-19 67.4 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Presenilin PF01080.17 OPL32927.1 - 0.39 9.4 2.6 0.49 9.1 2.6 1.1 1 0 0 1 1 1 0 Presenilin zf-CHC2 PF01807.20 OPL32929.1 - 0.011 15.5 0.4 0.056 13.3 0.1 2.2 1 1 1 2 2 2 0 CHC2 zinc finger zf_PR_Knuckle PF18445.1 OPL32930.1 - 0.0044 16.8 0.4 0.0044 16.8 0.4 2.4 2 0 0 2 2 2 1 PR zinc knuckle motif HSP70 PF00012.20 OPL32931.1 - 3.5e-05 22.2 0.0 4.5e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein SNAP-25 PF00835.19 OPL32931.1 - 0.27 11.6 4.0 1.7 9.0 4.0 2.1 1 1 0 1 1 1 0 SNAP-25 family XhlA PF10779.9 OPL32932.1 - 0.37 11.0 4.9 0.87 9.8 2.5 2.1 1 1 1 2 2 2 0 Haemolysin XhlA ABC_tran PF00005.27 OPL32933.1 - 1.2e-17 64.7 0.0 1.4e-17 64.5 0.0 1.0 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 OPL32933.1 - 0.0022 18.0 0.0 0.0029 17.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 OPL32933.1 - 0.02 14.6 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.17 OPL32933.1 - 0.034 14.2 0.0 0.051 13.7 0.0 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain DUF815 PF05673.13 OPL32933.1 - 0.067 12.3 0.0 0.087 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_21 PF13304.6 OPL32933.1 - 0.1 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Methyltransf_12 PF08242.12 OPL32933.1 - 0.11 13.2 0.0 0.15 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain AAA_23 PF13476.6 OPL32933.1 - 0.14 12.7 0.0 0.2 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 OPL32933.1 - 0.18 12.2 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain DUF945 PF06097.11 OPL32934.1 - 0.013 14.7 1.1 0.015 14.4 1.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) 4HBT PF03061.22 OPL32935.1 - 1e-11 45.0 0.1 1.4e-11 44.6 0.1 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 OPL32935.1 - 0.00062 20.1 0.0 0.0008 19.7 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF4442 PF14539.6 OPL32935.1 - 0.0064 16.6 0.0 0.0079 16.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) DctQ PF04290.12 OPL32935.1 - 0.23 11.4 0.0 0.36 10.7 0.0 1.3 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component Roc PF08477.13 OPL32937.1 - 4.3e-10 39.9 0.1 0.00029 21.0 0.1 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL32937.1 - 0.00033 20.3 0.1 0.014 15.0 0.1 2.2 2 0 0 2 2 2 1 Ras family PduV-EutP PF10662.9 OPL32937.1 - 0.01 15.6 0.1 0.056 13.2 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 OPL32937.1 - 0.018 15.1 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Dynamin family MMR_HSR1 PF01926.23 OPL32937.1 - 0.038 14.1 0.1 0.066 13.3 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 OPL32937.1 - 0.044 13.1 0.0 0.069 12.5 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Arf PF00025.21 OPL32937.1 - 0.051 13.0 0.0 0.091 12.2 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Vmethyltransf PF01660.17 OPL32937.1 - 0.07 12.0 0.0 0.079 11.8 0.0 1.2 1 0 0 1 1 1 0 Viral methyltransferase DUF4201 PF13870.6 OPL32938.1 - 5.7e-42 143.4 23.2 5.7e-42 143.4 23.2 2.8 3 1 0 3 3 3 2 Domain of unknown function (DUF4201) LZ3wCH PF18517.1 OPL32938.1 - 0.025 14.7 1.5 0.72 10.0 0.5 2.8 2 0 0 2 2 2 0 Leucine zipper with capping helix domain EF-hand_7 PF13499.6 OPL32939.1 - 1.6e-09 38.0 9.3 2.6e-06 27.8 1.5 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 OPL32939.1 - 6e-08 32.4 5.3 1.6e-06 27.8 1.2 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 OPL32939.1 - 1.1e-07 31.2 12.1 0.0033 17.2 0.3 4.3 3 1 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 OPL32939.1 - 3.1e-07 29.5 11.0 0.0059 16.1 0.0 4.0 5 0 0 5 5 5 2 EF hand EF-hand_9 PF14658.6 OPL32939.1 - 3e-06 27.5 0.1 0.003 17.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 OPL32939.1 - 0.023 14.7 4.1 0.028 14.4 2.4 1.9 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand RNA_pol_Rpb4 PF03874.16 OPL32939.1 - 0.037 14.4 0.5 0.084 13.2 0.5 1.5 1 1 0 1 1 1 0 RNA polymerase Rpb4 POTRA_2 PF08479.11 OPL32939.1 - 0.046 13.6 0.0 0.93 9.4 0.0 2.1 2 0 0 2 2 2 0 POTRA domain, ShlB-type RRM_3 PF08777.11 OPL32939.1 - 0.075 13.1 0.3 0.24 11.5 0.1 1.9 1 1 1 2 2 2 0 RNA binding motif Lig_chan PF00060.26 OPL32940.1 - 2.4e-23 82.6 0.2 3.6e-23 82.0 0.2 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 OPL32940.1 - 3.3e-08 33.7 0.0 8.4e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 OPL32940.1 - 7.2e-08 32.1 0.0 1.3e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF3367 PF11847.8 OPL32940.1 - 0.092 10.6 0.1 0.14 10.0 0.1 1.1 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase PDR_CDR PF06422.12 OPL32940.1 - 0.1 12.5 1.7 0.35 10.8 0.1 2.2 2 0 0 2 2 2 0 CDR ABC transporter Minor_capsid_3 PF12691.7 OPL32940.1 - 0.13 12.6 0.0 0.85 10.0 0.0 2.0 2 0 0 2 2 2 0 Minor capsid protein from bacteriophage Pkinase PF00069.25 OPL32942.1 - 7.5e-11 41.9 0.9 1.2e-10 41.3 0.9 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL32942.1 - 2.1e-05 24.0 0.7 3.8e-05 23.1 0.7 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 OPL32942.1 - 3.2e-05 23.4 0.3 4.5e-05 22.9 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 OPL32942.1 - 0.033 13.8 0.2 0.057 13.0 0.2 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 OPL32942.1 - 0.055 13.4 0.0 0.074 13.0 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mlf1IP PF10248.9 OPL32943.1 - 0.51 10.3 2.4 0.66 9.9 2.4 1.2 1 1 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein Ig_3 PF13927.6 OPL32944.1 - 2e-07 31.5 0.0 3.8e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL32944.1 - 2.7e-05 24.1 0.0 4.1e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 OPL32944.1 - 0.00015 21.9 0.0 0.00027 21.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL32944.1 - 0.0032 17.8 0.0 0.01 16.2 0.0 1.8 1 1 1 2 2 2 1 Immunoglobulin domain Ig_4 PF16680.5 OPL32944.1 - 0.0049 17.1 0.3 2.1 8.6 0.0 2.6 2 1 1 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Phage_Treg PF04761.12 OPL32944.1 - 0.046 13.8 0.0 0.092 12.9 0.0 1.5 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator DUF3929 PF13066.6 OPL32944.1 - 0.15 12.1 2.2 31 4.7 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3929) LRR_4 PF12799.7 OPL32945.1 - 3.6e-17 62.2 26.4 1.3e-05 25.5 0.3 3.4 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 OPL32945.1 - 5.2e-17 61.4 6.5 4.3e-07 29.6 0.1 3.4 2 2 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 OPL32945.1 - 1.9e-08 33.7 5.1 0.068 13.8 0.2 4.6 4 1 1 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 OPL32945.1 - 2.6e-07 30.1 6.3 0.089 12.9 0.5 4.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_9 PF14580.6 OPL32945.1 - 0.00024 20.7 0.4 0.0003 20.3 0.4 1.2 1 0 0 1 1 1 1 Leucine-rich repeat zf-C3HC4_3 PF13920.6 OPL32946.1 - 4.8e-14 51.9 11.4 4.8e-14 51.9 11.4 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL32946.1 - 3.6e-06 26.7 10.0 8.5e-06 25.5 10.0 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 PMP22_Claudin PF00822.20 OPL32946.1 - 3.9e-05 23.6 10.7 6.4e-05 22.9 10.7 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family zf-RING_5 PF14634.6 OPL32946.1 - 7.3e-05 22.6 12.3 7.3e-05 22.6 12.3 2.4 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 OPL32946.1 - 8.6e-05 22.8 13.2 8.6e-05 22.8 13.2 2.3 2 1 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 OPL32946.1 - 0.0014 18.4 13.3 0.0014 18.4 13.3 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Cation_efflux PF01545.21 OPL32946.1 - 0.013 15.2 1.1 0.018 14.8 1.1 1.1 1 0 0 1 1 1 0 Cation efflux family Mem_trans PF03547.18 OPL32946.1 - 0.036 12.5 1.7 0.041 12.3 1.7 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF1129 PF06570.11 OPL32946.1 - 0.44 10.0 4.4 0.65 9.5 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Claudin_2 PF13903.6 OPL32946.1 - 0.49 10.1 11.8 0.73 9.5 11.8 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF4199 PF13858.6 OPL32946.1 - 0.73 10.2 6.9 1.1 9.6 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Na_Ala_symp PF01235.17 OPL32946.1 - 0.78 9.0 6.2 0.14 11.5 2.5 1.5 1 1 1 2 2 2 0 Sodium:alanine symporter family GPI2 PF06432.11 OPL32946.1 - 1.5 8.2 7.9 2 7.8 7.9 1.1 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase CDC37_C PF08564.10 OPL32948.1 - 0.046 13.9 0.4 0.096 12.8 0.4 1.5 1 0 0 1 1 1 0 Cdc37 C terminal domain ENT PF03735.14 OPL32948.1 - 0.048 13.7 0.2 0.087 12.9 0.2 1.4 1 0 0 1 1 1 0 ENT domain Ank_2 PF12796.7 OPL32949.1 - 6.5e-09 36.3 0.5 0.00031 21.3 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 OPL32949.1 - 2.1e-07 31.1 0.1 0.002 18.4 0.0 2.7 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 OPL32949.1 - 2.1e-07 31.3 0.1 0.013 16.0 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 OPL32949.1 - 5.1e-06 26.7 0.5 0.17 12.4 0.1 2.6 2 1 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 OPL32949.1 - 2.5e-05 24.3 0.0 0.22 12.2 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat DUF948 PF06103.11 OPL32950.1 - 0.058 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) HAD_2 PF13419.6 OPL32950.1 - 0.95 9.5 5.5 10 6.1 0.1 3.1 3 1 1 4 4 4 0 Haloacid dehalogenase-like hydrolase Ribosomal_L22 PF00237.19 OPL32951.1 - 6.4e-19 68.1 0.3 8.9e-19 67.6 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Stanniocalcin PF03298.13 OPL32952.1 - 8.3e-10 38.3 0.6 9.9e-10 38.1 0.6 1.1 1 0 0 1 1 1 1 Stanniocalcin family Conotoxin PF02950.17 OPL32952.1 - 0.011 16.7 1.7 0.023 15.7 0.0 2.1 2 0 0 2 2 2 0 Conotoxin Ifi-6-16 PF06140.13 OPL32953.1 - 2.3e-18 65.9 16.7 2.3e-18 65.9 16.7 1.6 1 1 0 1 1 1 1 Interferon-induced 6-16 family Sulfotransfer_1 PF00685.27 OPL32954.1 - 8.2e-13 48.4 0.8 4e-11 42.9 0.8 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 OPL32954.1 - 2.4e-06 28.1 0.4 9.6e-05 22.9 0.1 2.2 2 0 0 2 2 2 1 Sulfotransferase family DUF2672 PF10878.8 OPL32954.1 - 0.13 12.2 0.0 1.6 8.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2672) HSP70 PF00012.20 OPL32955.1 - 1.4e-13 50.0 0.0 3.9e-13 48.5 0.0 1.7 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL32955.1 - 0.0039 16.1 0.0 0.2 10.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein StbA PF06406.11 OPL32955.1 - 0.057 12.6 0.0 2.8 7.1 0.0 2.2 2 0 0 2 2 2 0 StbA protein CPBP PF02517.16 OPL32956.1 - 2.1e-08 34.4 3.3 3.4e-08 33.7 3.3 1.4 1 0 0 1 1 1 1 CPBP intramembrane metalloprotease AGTRAP PF06396.11 OPL32957.1 - 7.7e-09 35.5 0.3 1.5e-07 31.3 0.3 2.1 1 1 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) TMEM238 PF15125.6 OPL32957.1 - 1.1 9.6 4.5 2.5 8.4 0.6 2.4 1 1 1 2 2 2 0 TMEM238 protein family Y_phosphatase PF00102.27 OPL32958.1 - 1.9e-60 204.4 5.4 2.5e-33 115.6 0.0 2.4 3 0 0 3 3 3 2 Protein-tyrosine phosphatase DSPc PF00782.20 OPL32958.1 - 1.4e-07 31.4 0.1 5.2e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 OPL32958.1 - 0.00099 19.1 0.1 0.0023 17.9 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 OPL32958.1 - 0.0088 16.2 0.1 0.026 14.7 0.0 1.9 2 0 0 2 2 2 1 Inositol hexakisphosphate Sulfatase_C PF14707.6 OPL32959.1 - 0.09 13.5 0.1 0.19 12.5 0.1 1.5 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase BTB PF00651.31 OPL32961.1 - 9.8e-15 54.8 0.1 3.2e-14 53.1 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 OPL32961.1 - 1.1e-07 31.9 0.4 1.1e-07 31.9 0.4 6.0 6 0 0 6 6 6 1 Zinc-finger double domain zf-C2H2 PF00096.26 OPL32961.1 - 1.3e-06 28.5 54.9 0.00091 19.6 3.2 7.6 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 OPL32961.1 - 0.00028 21.5 49.7 0.032 15.1 1.9 7.5 7 0 0 7 7 7 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 OPL32961.1 - 0.00035 20.3 3.8 0.00035 20.3 3.8 4.2 4 0 0 4 4 4 1 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 OPL32961.1 - 0.22 11.9 0.1 0.22 11.9 0.1 5.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 OPL32961.1 - 3.6 8.1 27.2 0.59 10.6 0.2 5.5 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 OPL32961.1 - 5.2 7.4 10.6 6.3 7.2 7.3 2.7 1 1 1 2 2 2 0 C2H2-type zinc ribbon zinc_ribbon_4 PF13717.6 OPL32961.1 - 7.3 6.6 7.8 1.8 8.5 1.6 2.9 3 0 0 3 3 3 0 zinc-ribbon domain C1q PF00386.21 OPL32962.1 - 0.0017 18.6 0.0 0.0017 18.6 0.0 1.1 1 0 0 1 1 1 1 C1q domain FlxA PF14282.6 OPL32963.1 - 0.4 10.7 3.3 0.32 11.0 0.7 2.0 2 0 0 2 2 2 0 FlxA-like protein zf-C2H2 PF00096.26 OPL32964.1 - 1.1e-10 41.4 9.4 7.9e-06 26.0 0.8 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 OPL32964.1 - 1.8e-08 34.4 9.6 4.1e-05 23.8 1.2 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 OPL32964.1 - 6.2e-08 32.8 6.8 0.00051 20.7 0.4 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-BED PF02892.15 OPL32964.1 - 2.1e-05 24.4 7.9 7.2e-05 22.7 0.2 2.3 2 0 0 2 2 2 1 BED zinc finger zf-C2H2_2 PF12756.7 OPL32964.1 - 0.00038 20.7 8.2 0.1 12.9 0.5 2.1 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 OPL32964.1 - 0.00086 19.5 2.1 0.0013 19.0 2.1 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 OPL32964.1 - 0.00097 19.1 5.2 0.16 12.0 0.5 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger DUF4764 PF15961.5 OPL32964.1 - 0.0012 17.7 0.7 0.0012 17.7 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) OSTMP1 PF09777.9 OPL32964.1 - 0.0019 17.6 3.7 0.0024 17.3 3.7 1.0 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor zf-C2H2_jaz PF12171.8 OPL32964.1 - 0.0027 18.0 5.7 0.27 11.6 1.5 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 OPL32964.1 - 0.0031 17.9 2.9 0.17 12.3 0.4 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 OPL32964.1 - 0.0081 15.8 0.5 0.013 15.1 0.4 1.5 1 1 0 1 1 1 1 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_15 PF17032.5 OPL32964.1 - 0.017 15.9 2.9 0.017 15.9 2.9 1.5 1 1 0 1 1 1 0 zinc-ribbon family zf-C2H2_11 PF16622.5 OPL32964.1 - 0.037 13.8 0.7 0.037 13.8 0.7 1.8 2 0 0 2 2 2 0 zinc-finger C2H2-type DUF629 PF04780.12 OPL32964.1 - 0.048 12.2 4.1 1.6 7.1 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Zn-ribbon_8 PF09723.10 OPL32964.1 - 0.2 11.8 4.8 0.37 10.9 3.3 2.1 1 1 1 2 2 2 0 Zinc ribbon domain zinc_ribbon_10 PF10058.9 OPL32964.1 - 0.4 10.5 3.3 1.7 8.4 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Ribosomal_L37ae PF01780.19 OPL32964.1 - 0.72 10.0 9.3 0.14 12.3 1.2 2.3 1 1 1 2 2 2 0 Ribosomal L37ae protein family Rubredoxin_2 PF18073.1 OPL32964.1 - 1.2 9.0 4.9 2.8 7.7 0.7 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain LRR_6 PF13516.6 OPL32965.1 - 0.043 13.9 0.4 2.1 8.6 0.0 2.7 3 0 0 3 3 3 0 Leucine Rich repeat MAM PF00629.23 OPL32967.1 - 1.1e-44 152.1 1.7 1.9e-35 122.2 0.1 2.1 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu MAM PF00629.23 OPL32968.1 - 4.7e-15 55.9 0.1 8.9e-15 55.0 0.0 1.5 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu AA_permease_2 PF13520.6 OPL32969.1 - 7.6e-30 104.1 23.7 8.5e-30 103.9 23.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 OPL32969.1 - 4.5e-15 55.2 19.9 5.7e-15 54.9 19.9 1.0 1 0 0 1 1 1 1 Amino acid permease C1q PF00386.21 OPL32970.1 - 2e-10 41.0 0.0 3.5e-10 40.2 0.0 1.4 1 1 0 1 1 1 1 C1q domain HIN PF02760.15 OPL32970.1 - 0.03 14.0 0.3 0.042 13.5 0.3 1.2 1 0 0 1 1 1 0 HIN-200/IF120x domain EGF PF00008.27 OPL32971.1 - 1.5e-17 63.6 24.7 9.3e-09 35.4 10.6 2.5 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 OPL32971.1 - 4.5e-13 49.3 24.9 7.4e-07 29.6 4.1 3.2 3 0 0 3 3 3 2 Human growth factor-like EGF EGF_CA PF07645.15 OPL32971.1 - 2.9e-08 33.8 29.6 0.00032 20.8 9.8 2.2 2 0 0 2 2 2 2 Calcium-binding EGF domain EGF_2 PF07974.13 OPL32971.1 - 4.8e-06 26.8 27.8 0.0015 18.9 7.5 2.5 2 1 0 2 2 2 2 EGF-like domain Plasmod_Pvs28 PF06247.11 OPL32971.1 - 0.00026 21.2 24.4 0.04 14.2 7.5 2.3 2 0 0 2 2 2 2 Pvs28 EGF domain FXa_inhibition PF14670.6 OPL32971.1 - 0.0016 18.7 24.2 0.05 13.9 10.4 2.7 1 1 1 2 2 2 2 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 OPL32971.1 - 0.0017 18.5 29.2 0.14 12.4 10.7 2.7 2 1 0 2 2 2 2 EGF domain Laminin_EGF PF00053.24 OPL32971.1 - 0.04 14.0 23.6 0.53 10.5 8.0 2.4 1 1 1 2 2 2 0 Laminin EGF domain cEGF PF12662.7 OPL32971.1 - 0.048 13.6 2.9 0.048 13.6 2.9 5.3 5 1 0 5 5 5 0 Complement Clr-like EGF-like EGF PF00008.27 OPL32972.1 - 9.8e-23 80.1 51.7 8e-08 32.4 8.8 5.5 5 0 0 5 5 5 5 EGF-like domain hEGF PF12661.7 OPL32972.1 - 1.1e-14 54.4 56.3 2.3e-07 31.2 9.5 5.6 6 0 0 6 6 6 3 Human growth factor-like EGF EGF_CA PF07645.15 OPL32972.1 - 1.6e-10 41.0 55.1 3.8e-05 23.8 7.9 5.1 4 1 1 5 5 5 4 Calcium-binding EGF domain cEGF PF12662.7 OPL32972.1 - 4.7e-06 26.4 48.1 0.00062 19.6 2.6 7.2 6 1 0 6 6 6 3 Complement Clr-like EGF-like EGF_2 PF07974.13 OPL32972.1 - 0.0074 16.6 57.3 0.089 13.2 8.8 5.1 3 1 2 5 5 5 3 EGF-like domain FXa_inhibition PF14670.6 OPL32972.1 - 0.011 16.0 51.5 0.072 13.4 12.2 5.0 2 2 3 5 5 5 0 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 OPL32972.1 - 1.6 9.1 39.3 4.1 7.8 3.4 4.8 4 1 0 4 4 4 0 Pvs28 EGF domain EGF_3 PF12947.7 OPL32972.1 - 2.6 8.3 45.9 0.22 11.7 8.2 5.3 2 2 3 5 5 5 0 EGF domain VWA PF00092.28 OPL32973.1 - 4.9e-24 85.5 2.3 5.7e-24 85.3 2.3 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL32973.1 - 2.3e-12 47.5 0.2 3.5e-12 46.9 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Sec23_trunk PF04811.15 OPL32973.1 - 0.00029 20.5 1.6 0.0054 16.3 0.2 2.3 1 1 1 2 2 2 1 Sec23/Sec24 trunk domain VWA_CoxE PF05762.14 OPL32973.1 - 0.067 12.6 0.3 0.14 11.6 0.3 1.5 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein Glyco_transf_7N PF13733.6 OPL32977.1 - 5.8e-39 132.8 0.2 7.7e-39 132.4 0.2 1.1 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 DUF3978 PF13123.6 OPL32977.1 - 0.042 13.6 0.0 0.054 13.2 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3978) Lig_chan PF00060.26 OPL32978.1 - 4.4e-40 137.0 1.4 6e-40 136.5 1.4 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 OPL32978.1 - 6.5e-22 77.9 0.2 4.5e-15 55.8 0.0 2.3 1 1 1 2 2 2 2 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 OPL32978.1 - 2.5e-14 53.2 0.0 5.1e-14 52.2 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 TMEM132D_C PF15706.5 OPL32978.1 - 0.065 13.0 0.3 3.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Shisa PF13908.6 OPL32978.1 - 0.11 12.7 0.1 12 6.1 0.0 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator CLN3 PF02487.17 OPL32979.1 - 2.9e-35 122.1 1.8 3.4e-35 121.9 1.8 1.0 1 0 0 1 1 1 1 CLN3 protein Acetyltransf_1 PF00583.25 OPL32980.1 - 1.1e-14 54.7 0.0 1.5e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 OPL32980.1 - 2e-09 37.5 0.1 2.4e-09 37.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 OPL32980.1 - 6.4e-09 36.1 0.0 9.5e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 OPL32980.1 - 4.4e-07 29.8 0.0 7.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 OPL32980.1 - 0.00086 19.4 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 OPL32980.1 - 0.0063 16.5 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 OPL32980.1 - 0.02 14.4 0.1 0.031 13.7 0.1 1.6 1 1 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_3 PF13302.7 OPL32980.1 - 0.023 15.4 0.0 0.033 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 OPL32980.1 - 0.041 13.6 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ MAM PF00629.23 OPL32981.1 - 2.2e-42 144.7 12.5 2.3e-36 125.1 0.6 2.0 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu AlphaC_N PF08829.10 OPL32981.1 - 0.033 14.2 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 Alpha C protein N terminal An_peroxidase PF03098.15 OPL32982.1 - 6.8e-38 130.5 0.0 8.1e-38 130.3 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Macro PF01661.21 OPL32983.1 - 1.6e-22 79.8 0.1 3.7e-22 78.6 0.1 1.6 1 0 0 1 1 1 1 Macro domain HSP20 PF00011.21 OPL32983.1 - 0.12 12.6 0.6 1.1 9.5 0.2 2.6 3 0 0 3 3 3 0 Hsp20/alpha crystallin family DUF3917 PF13055.6 OPL32983.1 - 0.13 12.7 0.0 1.3 9.5 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3917) Tcp10_C PF07202.13 OPL32983.1 - 0.27 11.2 1.3 11 5.9 0.6 2.4 2 0 0 2 2 2 0 T-complex protein 10 C-terminus RRM_1 PF00076.22 OPL32984.1 - 0.0058 16.4 0.6 0.24 11.2 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NID PF07292.13 OPL32984.1 - 0.0066 17.1 5.6 1.3 9.7 0.0 4.4 3 2 1 4 4 4 1 Nmi/IFP 35 domain (NID) RRM_Rrp7 PF17799.1 OPL32984.1 - 0.015 15.1 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain Nup35_RRM_2 PF14605.6 OPL32984.1 - 0.042 13.9 0.1 0.16 12.0 0.1 2.0 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF257 PF03192.13 OPL32984.1 - 0.064 13.0 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Pyrococcus protein of unknown function, DUF257 Pkinase_Tyr PF07714.17 OPL32985.1 - 6.3e-20 71.5 1.3 1.7e-13 50.5 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 OPL32985.1 - 4.5e-07 29.5 0.6 2.4e-05 23.8 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain fn3 PF00041.21 OPL32985.1 - 0.00026 21.3 0.6 0.00055 20.2 0.6 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DUF3309 PF11752.8 OPL32985.1 - 0.0055 16.7 0.1 0.011 15.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3309) Protocadherin PF08374.11 OPL32987.1 - 0.0082 16.2 0.3 0.013 15.5 0.3 1.3 1 0 0 1 1 1 1 Protocadherin Flocculin PF00624.18 OPL32987.1 - 0.051 13.8 5.8 0.051 13.8 5.8 2.9 3 0 0 3 3 3 0 Flocculin repeat Syndecan PF01034.20 OPL32987.1 - 0.053 13.4 3.5 0.088 12.7 3.5 1.3 1 0 0 1 1 1 0 Syndecan domain TSP_1 PF00090.19 OPL32988.1 - 8.5e-14 51.5 5.3 8.5e-14 51.5 5.3 3.2 2 1 0 2 2 2 1 Thrombospondin type 1 domain Ephrin_rec_like PF07699.13 OPL32988.1 - 1e-11 44.4 8.0 1e-11 44.4 8.0 4.5 5 1 1 6 6 6 1 Putative ephrin-receptor like EGF PF00008.27 OPL32988.1 - 2.6e-10 40.4 25.4 2.3e-05 24.6 3.7 4.3 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.7 OPL32988.1 - 1.2e-05 25.7 17.3 0.0005 20.6 3.9 5.2 5 0 0 5 5 5 2 Human growth factor-like EGF DUF3827 PF12877.7 OPL32988.1 - 0.0088 14.5 2.7 0.013 13.9 2.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) TMEM154 PF15102.6 OPL32988.1 - 0.016 15.1 0.1 0.038 13.9 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family EGF_CA PF07645.15 OPL32988.1 - 0.023 14.9 9.6 0.023 14.9 9.6 4.9 3 2 1 4 4 4 0 Calcium-binding EGF domain EphA2_TM PF14575.6 OPL32988.1 - 0.37 11.7 2.0 0.45 11.4 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Protocadherin PF08374.11 OPL32988.1 - 2.1 8.2 5.2 0.32 11.0 0.2 2.0 2 0 0 2 2 2 0 Protocadherin HCO3_cotransp PF00955.21 OPL32989.1 - 1.8e-94 317.4 2.5 3.1e-94 316.6 2.5 1.2 1 0 0 1 1 1 1 HCO3- transporter family MFS_MOT1 PF16983.5 OPL32989.1 - 3.3 8.2 7.0 2 8.9 2.1 2.2 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Neur_chan_memb PF02932.16 OPL32990.1 - 5.3e-12 46.3 1.1 5.3e-12 46.3 1.1 1.3 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region SLAC1 PF03595.17 OPL32990.1 - 0.003 16.9 2.5 0.023 14.0 1.6 1.9 2 0 0 2 2 2 1 Voltage-dependent anion channel SfLAP PF11139.8 OPL32990.1 - 0.011 15.2 1.0 0.011 15.2 1.0 1.7 2 0 0 2 2 2 0 Sap, sulfolipid-1-addressing protein Orf78 PF06024.12 OPL32990.1 - 0.055 13.8 0.2 11 6.4 0.2 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Alk_phosphatase PF00245.20 OPL32991.1 - 1.9e-91 307.1 5.6 5.4e-70 236.4 1.2 2.0 1 1 1 2 2 2 2 Alkaline phosphatase Metalloenzyme PF01676.18 OPL32991.1 - 0.0023 17.3 0.0 0.0045 16.4 0.0 1.5 2 0 0 2 2 2 1 Metalloenzyme superfamily Ldl_recept_a PF00057.18 OPL32992.1 - 6e-15 55.2 38.8 3.3e-08 33.6 8.6 3.9 2 1 0 3 3 3 2 Low-density lipoprotein receptor domain class A SRCR PF00530.18 OPL32992.1 - 3.8e-13 49.8 0.7 3.8e-13 49.8 0.7 2.1 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 OPL32992.1 - 5.2e-06 26.9 0.5 5.2e-06 26.9 0.5 1.7 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain PRKCSH-like PF12999.7 OPL32992.1 - 8.9 6.1 25.7 3.7 7.3 19.9 2.1 1 1 1 2 2 2 0 Glucosidase II beta subunit-like HEPN_DZIP3 PF18738.1 OPL32993.1 - 3.7e-27 94.8 0.1 4.4e-27 94.6 0.1 1.1 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN DUF3176 PF11374.8 OPL32993.1 - 0.053 13.7 0.0 0.077 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3176) PMSI1 PF15322.6 OPL32994.1 - 1.9 7.9 4.9 0.5 9.8 0.4 2.1 2 0 0 2 2 2 0 Protein missing in infertile sperm 1, putative C1_1 PF00130.22 OPL32995.1 - 5.1e-11 42.3 11.5 8.3e-11 41.6 11.5 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DMPK_coil PF08826.10 OPL32995.1 - 3.3e-07 30.3 11.1 3.3e-07 30.3 11.1 1.8 2 0 0 2 2 2 1 DMPK coiled coil domain like LdpA_C PF12617.8 OPL32995.1 - 0.038 13.6 0.2 0.14 11.8 0.1 1.7 2 0 0 2 2 2 0 Iron-Sulfur binding protein C terminal TIR-like PF10137.9 OPL32995.1 - 0.046 13.7 0.6 0.078 12.9 0.6 1.4 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain V_ATPase_I PF01496.19 OPL32995.1 - 0.18 9.7 3.4 0.18 9.7 3.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 OPL32995.1 - 2.5 8.0 8.7 12 5.8 8.4 2.1 1 1 1 2 2 2 0 Septum formation initiator Tho2 PF11262.8 OPL32995.1 - 5.6 6.1 9.4 3.5 6.8 7.6 1.5 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF2951 PF11166.8 OPL32995.1 - 6.6 7.0 10.0 5 7.4 2.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) Peptidase_C14 PF00656.22 OPL32996.1 - 4.9e-09 36.5 0.5 7.3e-09 35.9 0.5 1.3 1 0 0 1 1 1 1 Caspase domain MSA-2c PF12238.8 OPL32996.1 - 0.98 9.4 5.5 2.4 8.1 5.5 1.8 1 1 0 1 1 1 0 Merozoite surface antigen 2c FG-GAP PF01839.23 OPL32999.1 - 4.6e-08 33.1 2.0 8.6e-08 32.2 2.0 1.5 1 0 0 1 1 1 1 FG-GAP repeat FG-GAP_2 PF14312.6 OPL32999.1 - 0.06 13.6 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 FG-GAP repeat C1q PF00386.21 OPL33000.1 - 0.0024 18.1 0.0 0.0039 17.4 0.0 1.3 1 0 0 1 1 1 1 C1q domain TPR_2 PF07719.17 OPL33001.1 - 2.3e-31 105.3 0.0 3.6e-06 26.7 0.0 7.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 OPL33001.1 - 3.1e-30 101.8 0.1 2.4e-05 24.2 0.0 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 OPL33001.1 - 4e-27 92.9 1.2 3.1e-07 29.9 0.0 7.2 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 OPL33001.1 - 3.4e-24 83.4 4.0 1.9e-06 27.8 0.1 8.8 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 OPL33001.1 - 3e-23 82.1 0.2 7.5e-09 36.0 0.0 5.1 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 OPL33001.1 - 2.9e-19 68.5 4.0 8.9e-12 44.5 0.1 7.3 7 1 2 9 9 8 3 TPR repeat TPR_12 PF13424.6 OPL33001.1 - 1.2e-16 60.7 0.0 9.6e-06 25.8 0.0 6.8 4 2 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 OPL33001.1 - 2.1e-16 59.4 0.0 0.01 16.4 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 OPL33001.1 - 1e-14 54.9 0.0 3.6e-09 37.1 0.0 4.4 3 2 2 5 5 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 OPL33001.1 - 2.6e-14 52.7 0.0 0.035 14.9 0.0 7.9 3 2 5 8 8 8 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 OPL33001.1 - 1.1e-10 41.4 1.3 0.65 10.1 0.0 5.4 3 2 2 5 5 5 3 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 OPL33001.1 - 1e-08 35.2 0.0 0.00068 19.7 0.0 5.0 4 2 2 6 6 6 2 Tetratricopeptide repeat Coatomer_E PF04733.14 OPL33001.1 - 1e-07 31.7 0.2 7.9e-05 22.2 0.0 2.6 1 1 2 3 3 3 2 Coatomer epsilon subunit HrpB1_HrpK PF09613.10 OPL33001.1 - 1.5e-07 31.1 0.0 0.00051 19.7 0.0 3.2 2 1 1 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_7 PF13176.6 OPL33001.1 - 7.4e-07 28.8 0.1 0.0046 16.9 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 OPL33001.1 - 1.7e-06 27.7 4.8 0.49 10.3 0.0 6.4 6 1 1 7 7 7 1 Tetratricopeptide repeat NARP1 PF12569.8 OPL33001.1 - 1e-05 24.7 0.9 8.6e-05 21.6 0.2 2.5 2 1 1 3 3 3 1 NMDA receptor-regulated protein 1 TPR_21 PF09976.9 OPL33001.1 - 3e-05 23.8 0.1 0.032 14.0 0.0 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 OPL33001.1 - 0.0002 20.7 0.1 0.25 10.5 0.0 3.3 2 1 2 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 OPL33001.1 - 0.0002 21.5 0.3 0.32 11.2 0.0 3.5 3 2 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 OPL33001.1 - 0.023 14.4 0.5 0.08 12.6 0.5 2.0 1 1 0 1 1 1 0 26S proteasome subunit RPN7 TPR_MalT PF17874.1 OPL33001.1 - 0.038 13.4 0.0 0.48 9.7 0.0 2.3 2 0 0 2 2 2 0 MalT-like TPR region SNAP PF14938.6 OPL33001.1 - 0.047 13.1 0.9 2.7 7.3 0.0 3.2 2 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP DUF1491 PF07372.12 OPL33001.1 - 0.096 13.1 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) APP_E2 PF12925.7 OPL33001.1 - 0.13 12.0 0.5 6 6.5 0.3 3.0 2 1 0 2 2 2 0 E2 domain of amyloid precursor protein Filamin PF00630.19 OPL33002.1 - 3.6e-05 24.5 0.0 0.00023 22.0 0.0 1.9 2 0 0 2 2 2 1 Filamin/ABP280 repeat Y_Y_Y PF07495.13 OPL33002.1 - 0.058 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Y_Y_Y domain Filamin PF00630.19 OPL33003.1 - 1.4e-13 51.6 0.3 1.8e-08 35.1 0.0 2.3 2 1 0 2 2 2 2 Filamin/ABP280 repeat Phenol_monoox PF04663.12 OPL33003.1 - 0.0068 16.5 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 Phenol hydroxylase conserved region Filamin PF00630.19 OPL33004.1 - 2.6e-15 57.1 0.0 3.6e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Filamin/ABP280 repeat G-patch_2 PF12656.7 OPL33007.1 - 2.6e-23 81.9 0.5 2.6e-23 81.9 0.5 2.5 2 0 0 2 2 2 1 G-patch domain G-patch PF01585.23 OPL33007.1 - 1.5e-09 37.6 1.2 3.2e-09 36.5 1.2 1.6 1 0 0 1 1 1 1 G-patch domain KOW PF00467.29 OPL33007.1 - 3.7e-09 36.2 0.0 0.00049 20.0 0.0 2.9 2 0 0 2 2 2 2 KOW motif KN17_SH3 PF18131.1 OPL33007.1 - 8.2e-09 35.5 1.1 5.6e-06 26.4 0.1 2.6 2 0 0 2 2 2 2 KN17 SH3-like C-terminal domain PGP_phosphatase PF09419.10 OPL33007.1 - 0.033 13.8 0.1 0.055 13.1 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase CDC45 PF02724.14 OPL33007.1 - 0.16 10.2 15.2 0.24 9.7 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Sclerostin PF05463.11 OPL33007.1 - 0.18 11.5 3.4 0.35 10.5 3.4 1.5 1 0 0 1 1 1 0 Sclerostin (SOST) Zip PF02535.22 OPL33007.1 - 0.59 9.3 4.5 0.74 9.0 4.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 OPL33007.1 - 0.61 8.8 5.4 0.8 8.4 5.4 1.2 1 0 0 1 1 1 0 Presenilin ATP11 PF06644.11 OPL33007.1 - 3.4 7.4 12.0 6.1 6.6 12.0 1.3 1 0 0 1 1 1 0 ATP11 protein Atrophin-1 PF03154.15 OPL33007.1 - 3.4 5.8 11.2 4.5 5.4 11.2 1.1 1 0 0 1 1 1 0 Atrophin-1 family HEPN_DZIP3 PF18738.1 OPL33008.1 - 3.2e-22 78.8 0.1 3.8e-22 78.6 0.1 1.1 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN Cadherin PF00028.17 OPL33009.1 - 1.9e-22 79.5 6.4 1e-06 29.1 0.0 4.4 4 0 0 4 4 4 4 Cadherin domain DUF5011 PF16403.5 OPL33009.1 - 5.2 7.3 8.1 2.5 8.3 0.5 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF5011) CHRD PF07452.12 OPL33010.1 - 0.29 12.1 4.7 0.18 12.8 1.8 2.1 1 1 1 2 2 2 0 CHRD domain Lantibiotic_a PF14867.6 OPL33010.1 - 8.7 6.2 6.6 6.7 6.6 0.1 3.0 3 0 0 3 3 3 0 Lantibiotic alpha DEAD PF00270.29 OPL33011.1 - 7.5e-10 38.9 0.0 8.4e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 OPL33011.1 - 3.3e-05 24.0 0.0 4e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SoxE PF06525.11 OPL33011.1 - 0.14 11.6 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Sulfocyanin (SoxE) domain BIR PF00653.21 OPL33012.1 - 3.5e-43 146.1 13.6 3.5e-20 72.4 0.3 3.6 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain DUF642 PF04862.12 OPL33013.1 - 0.095 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF642) HSP70 PF00012.20 OPL33015.1 - 8.9e-09 34.1 0.0 3e-08 32.3 0.0 1.8 1 1 1 2 2 2 1 Hsp70 protein StbA PF06406.11 OPL33015.1 - 0.071 12.3 3.0 2 7.6 0.4 2.4 1 1 1 2 2 2 0 StbA protein DUF503 PF04456.12 OPL33015.1 - 0.12 12.2 1.9 0.17 11.7 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF503) DDR PF08841.10 OPL33015.1 - 0.13 11.2 0.3 0.42 9.5 0.0 1.8 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Myb_DNA-bind_5 PF13873.6 OPL33015.1 - 0.15 12.2 1.2 0.25 11.4 0.2 1.9 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Hydantoinase_A PF01968.18 OPL33015.1 - 0.2 10.9 0.0 2.2 7.5 0.1 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Pex24p PF06398.11 OPL33016.1 - 5.9e-07 28.8 21.7 0.00023 20.3 2.1 3.1 2 1 1 3 3 3 3 Integral peroxisomal membrane peroxin NPR1_interact PF15699.5 OPL33016.1 - 3.4 8.3 5.8 6.9 7.3 5.8 1.6 1 1 0 1 1 1 0 NPR1 interacting MIEAP PF16026.5 OPL33017.1 - 6.4e-09 36.3 0.2 6.4e-09 36.3 0.2 2.5 2 1 1 3 3 3 1 Mitochondria-eating protein V_ATPase_I PF01496.19 OPL33017.1 - 0.069 11.1 9.5 0.078 10.9 9.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Octopine_DH PF02317.17 OPL33017.1 - 0.22 11.6 3.9 2.3 8.3 1.2 2.3 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Golgin_A5 PF09787.9 OPL33017.1 - 0.23 10.9 24.7 0.18 11.2 23.6 1.4 1 1 0 1 1 1 0 Golgin subfamily A member 5 DUF3450 PF11932.8 OPL33017.1 - 0.63 9.3 15.3 1.1 8.5 14.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 OPL33017.1 - 1 9.9 28.1 0.25 11.9 24.1 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region Atg14 PF10186.9 OPL33017.1 - 1.2 8.1 14.0 1.7 7.7 14.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FapA PF03961.13 OPL33017.1 - 1.9 7.0 12.3 2.7 6.5 12.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A CENP-H PF05837.12 OPL33017.1 - 3.9 7.9 18.4 1.1 9.6 12.2 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Nup54 PF13874.6 OPL33017.1 - 5.8 7.0 13.1 1.1 9.4 8.0 2.3 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 SlyX PF04102.12 OPL33017.1 - 8 7.2 10.7 13 6.5 1.5 3.2 1 1 0 2 2 2 0 SlyX DTC PF18102.1 OPL33018.1 - 4.6e-38 130.4 0.3 5.6e-36 123.6 0.3 2.5 1 1 0 1 1 1 1 Deltex C-terminal domain Macro PF01661.21 OPL33018.1 - 3.4e-10 40.0 0.0 1.1e-09 38.4 0.0 1.9 1 0 0 1 1 1 1 Macro domain zf-RING_2 PF13639.6 OPL33018.1 - 3.9e-07 30.3 20.4 8e-07 29.3 13.1 2.9 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 OPL33018.1 - 6.6e-07 29.2 18.2 5.5e-06 26.2 13.1 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 OPL33018.1 - 5.2e-06 26.2 14.1 5.2e-06 26.2 14.1 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 OPL33018.1 - 7e-06 25.8 13.7 9e-06 25.5 10.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 OPL33018.1 - 0.00012 21.9 15.1 0.00012 21.9 15.1 3.2 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 OPL33018.1 - 0.00015 21.5 9.4 0.012 15.4 5.1 2.8 2 0 0 2 2 2 2 RING-like zinc finger zf-rbx1 PF12678.7 OPL33018.1 - 0.00019 21.7 13.8 0.0031 17.8 8.7 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 OPL33018.1 - 0.00048 20.1 6.3 0.00048 20.1 6.3 3.7 3 1 0 3 3 3 1 RING-type zinc-finger zf-RING_6 PF14835.6 OPL33018.1 - 0.0014 18.4 6.1 0.0049 16.7 6.1 1.9 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 OPL33018.1 - 0.0018 18.4 11.6 0.002 18.3 8.9 2.2 2 0 0 2 2 2 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 OPL33018.1 - 0.0076 16.1 18.0 0.2 11.5 14.5 3.5 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-C2H2_3 PF13878.6 OPL33018.1 - 0.22 11.4 2.4 0.92 9.4 0.5 2.9 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO Endonuclease_7 PF02945.15 OPL33018.1 - 0.26 11.3 2.7 0.61 10.1 2.7 1.5 1 0 0 1 1 1 0 Recombination endonuclease VII zf-C3HC4_5 PF17121.5 OPL33018.1 - 0.32 10.9 9.2 1.1 9.1 9.2 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 OPL33018.1 - 0.33 11.0 9.3 1.5 8.9 8.7 2.2 2 0 0 2 2 2 0 Double zinc ribbon zf-ANAPC11 PF12861.7 OPL33018.1 - 4.5 7.4 9.7 6 7.0 4.1 2.8 3 0 0 3 3 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger MIB_HERC2 PF06701.13 OPL33019.1 - 1.4e-18 66.9 3.3 6.2e-17 61.6 2.2 2.4 2 0 0 2 2 2 2 Mib_herc2 DUF4314 PF14192.6 OPL33019.1 - 0.014 15.3 0.5 0.49 10.4 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4314) Endonuc-dimeris PF09124.10 OPL33019.1 - 0.045 13.9 0.2 0.081 13.1 0.2 1.3 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation Glyco_transf_11 PF01531.16 OPL33020.1 - 1.3e-34 119.8 0.4 1.7e-34 119.4 0.4 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 11 O-FucT PF10250.9 OPL33020.1 - 0.00054 19.8 0.1 0.00078 19.2 0.1 1.3 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Ig_3 PF13927.6 OPL33021.1 - 3.5e-07 30.7 3.5 4.4e-05 24.0 1.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 OPL33021.1 - 2.8e-06 27.3 0.5 6.8e-06 26.1 0.1 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 OPL33021.1 - 2.4e-05 24.3 0.8 0.0017 18.4 0.1 2.5 1 1 1 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL33021.1 - 0.076 13.4 8.2 0.53 10.6 2.4 2.9 2 2 1 3 3 3 0 Immunoglobulin domain Ig_3 PF13927.6 OPL33022.1 - 3.1e-08 34.1 1.0 0.015 15.9 0.6 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 OPL33022.1 - 2.8e-06 27.3 0.3 0.37 10.9 0.1 3.9 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 OPL33022.1 - 0.039 14.1 0.9 0.14 12.3 0.9 2.0 1 1 0 1 1 1 0 Immunoglobulin domain VPS9 PF02204.18 OPL33024.1 - 0.0042 17.3 0.0 0.007 16.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Phospholip_A2_1 PF00068.19 OPL33025.1 - 1.5e-18 67.3 4.5 2e-18 66.9 4.5 1.2 1 0 0 1 1 1 1 Phospholipase A2 SH2 PF00017.24 OPL33026.1 - 9.9e-13 48.0 0.0 1.4e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 SH2 domain Fibrinogen_C PF00147.18 OPL33027.1 - 1.9e-22 80.1 2.1 2.2e-22 80.0 2.1 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Kringle PF00051.18 OPL33028.1 - 3.2e-52 174.8 34.2 3.3e-21 75.4 7.1 3.9 2 1 1 3 3 3 3 Kringle domain Lectin_C PF00059.21 OPL33028.1 - 2.1e-14 54.1 0.3 2.1e-14 54.1 0.3 2.2 2 1 0 2 2 2 1 Lectin C-type domain Toxin_18 PF08087.11 OPL33028.1 - 0.48 10.5 2.6 3.3 7.8 0.2 2.8 2 0 0 2 2 2 0 Conotoxin O-superfamily Toxin_5 PF05294.13 OPL33028.1 - 3.7 8.0 16.5 0.61 10.6 0.3 4.8 4 1 1 5 5 5 0 Scorpion short toxin Peptidase_C2 PF00648.21 OPL33029.1 - 5e-60 203.0 0.0 6.5e-60 202.7 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 OPL33029.1 - 3.4e-19 69.5 0.1 2.6e-13 50.5 0.0 2.2 2 0 0 2 2 2 2 Calpain large subunit, domain III RNB PF00773.19 OPL33030.1 - 6.8e-86 288.5 0.4 3.8e-52 177.6 0.2 2.1 1 1 1 2 2 2 2 RNB domain OB_Dis3 PF17849.1 OPL33030.1 - 3.5e-21 75.0 0.0 6.4e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 OPL33030.1 - 5.1e-08 33.0 0.0 1.1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Cold shock domain Rrp44_S1 PF17215.3 OPL33030.1 - 0.00014 21.7 0.1 0.00025 20.9 0.1 1.4 1 0 0 1 1 1 1 S1 domain Dis3l2_C_term PF17877.1 OPL33030.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal DUF1207 PF06727.11 OPL33030.1 - 0.13 11.2 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1207) ADAM17_MPD PF16698.5 OPL33031.1 - 7.9e-12 45.4 18.2 7.9e-12 45.4 18.2 2.9 3 0 0 3 3 3 1 Membrane-proximal domain, switch, for ADAM17 DUF2499 PF10693.9 OPL33031.1 - 0.025 14.8 0.0 0.041 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2499) GST_C_2 PF13410.6 OPL33032.1 - 9.4e-11 41.6 0.0 2e-10 40.5 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 OPL33032.1 - 4e-06 26.9 0.1 1.3e-05 25.3 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 OPL33032.1 - 0.00035 20.7 0.1 0.00099 19.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 OPL33032.1 - 0.064 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain LeuA_dimer PF08502.10 OPL33032.1 - 0.19 11.6 0.5 85 3.0 0.0 4.4 3 1 3 6 6 6 0 LeuA allosteric (dimerisation) domain Slx4 PF09494.10 OPL33032.1 - 7.5 6.6 22.8 63 3.6 0.4 5.9 1 1 3 4 4 4 0 Slx4 endonuclease RAB3GAP2_N PF14655.6 OPL33033.1 - 1.6e-43 149.6 0.0 1.6e-43 149.5 0.0 1.0 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus RAB3GAP2_C PF14656.6 OPL33034.1 - 1.1e-35 123.0 0.4 1.5e-35 122.5 0.4 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus Suppressor_P21 PF11479.8 OPL33034.1 - 0.087 13.0 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 RNA silencing suppressor P21 C-terminal domain DUF5399 PF17377.2 OPL33035.1 - 0.059 13.2 0.4 0.12 12.2 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5399) Herpes_U44 PF04533.13 OPL33035.1 - 0.35 10.5 4.1 7.6 6.1 0.5 2.2 2 0 0 2 2 2 0 Herpes virus U44 protein C1q PF00386.21 OPL33036.1 - 2.7e-13 50.2 0.0 3.3e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 C1q domain FIT1_2 PF17357.2 OPL33036.1 - 0.018 15.1 0.4 0.032 14.3 0.4 1.4 1 0 0 1 1 1 0 Facilitor Of iron transport 1 and 2 TNF PF00229.18 OPL33036.1 - 0.04 13.9 0.0 0.05 13.5 0.0 1.3 1 1 0 1 1 1 0 TNF(Tumour Necrosis Factor) family LRR_9 PF14580.6 OPL33037.1 - 7.5e-11 41.8 0.1 1.8e-10 40.6 0.1 1.6 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 OPL33037.1 - 5.4e-10 39.4 1.2 4.1e-05 23.8 0.3 3.8 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 OPL33037.1 - 2.7e-07 30.2 0.3 1.8e-06 27.6 0.2 2.5 2 1 0 2 2 2 1 Leucine rich repeat LRR_6 PF13516.6 OPL33037.1 - 0.0022 17.9 5.6 2.1 8.6 0.1 4.2 4 0 0 4 4 4 1 Leucine Rich repeat DUF424 PF04242.13 OPL33037.1 - 0.065 13.5 1.0 17 5.8 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF424) PMT2_N PF17987.1 OPL33037.1 - 0.095 12.9 0.6 0.45 10.7 0.2 2.2 2 0 0 2 2 2 0 Phosphoethanolamine N-methyltransferase 2 N-terminal C1q PF00386.21 OPL33038.1 - 2.6e-19 69.7 0.5 3.8e-19 69.1 0.5 1.3 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL33038.1 - 0.0064 16.4 0.1 0.0092 15.9 0.1 1.2 1 0 0 1 1 1 1 BclA C-terminal domain zf-C4 PF00105.18 OPL33040.1 - 1.3e-25 89.6 11.7 3.1e-25 88.4 11.7 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 OPL33040.1 - 0.016 14.8 0.0 0.045 13.3 0.0 1.7 1 0 0 1 1 1 0 Ligand-binding domain of nuclear hormone receptor Pox_J1 PF03338.15 OPL33040.1 - 0.057 13.3 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Poxvirus J1 protein Helicase_C PF00271.31 OPL33041.1 - 1e-14 54.8 0.0 2.1e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SIKE PF05769.11 OPL33041.1 - 0.062 13.2 0.5 0.091 12.7 0.5 1.2 1 0 0 1 1 1 0 SIKE family COG5 PF10392.9 OPL33041.1 - 0.11 12.7 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF5623 PF18536.1 OPL33041.1 - 0.19 12.0 0.9 16 5.8 0.1 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF5623) tRNA-synt_1b PF00579.25 OPL33042.1 - 8.3e-20 71.3 0.0 1.2e-13 51.1 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (W and Y) Invas_SpaK PF03519.14 OPL33042.1 - 0.083 13.0 0.0 0.26 11.4 0.0 1.8 2 0 0 2 2 2 0 Invasion protein B family RRM_1 PF00076.22 OPL33043.1 - 6.1e-16 58.0 0.0 9.5e-07 28.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 OPL33043.1 - 5.1e-11 42.2 0.4 5.9e-05 22.7 0.0 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 OPL33043.1 - 1.2e-10 41.5 0.1 1.1e-09 38.3 0.0 2.0 2 0 0 2 2 2 1 RRM-like domain RL PF17797.1 OPL33043.1 - 2.2e-05 24.3 0.0 0.016 15.1 0.0 2.4 2 0 0 2 2 2 2 RL domain RRM_3 PF08777.11 OPL33043.1 - 3.1e-05 24.0 0.0 0.029 14.4 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 OPL33043.1 - 8.3e-05 22.4 0.0 0.45 10.4 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif OmpA_like PF16961.5 OPL33043.1 - 0.0073 16.0 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Putative OmpA-OmpF-like porin family Limkain-b1 PF11608.8 OPL33043.1 - 0.0097 16.0 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 Limkain b1 DUF4523 PF15023.6 OPL33043.1 - 0.015 15.1 0.0 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Glycos_transf_2 PF00535.26 OPL33044.1 - 0.16 11.8 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 2 Chitin_synth_2 PF03142.15 OPL33044.1 - 0.16 10.5 0.0 0.16 10.5 0.0 1.0 1 0 0 1 1 1 0 Chitin synthase zf-C3HC4_3 PF13920.6 OPL33045.1 - 3.8e-12 45.9 4.4 3.8e-12 45.9 4.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 OPL33045.1 - 2.6e-07 30.5 5.7 6.9e-07 29.1 5.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 OPL33045.1 - 1.1e-05 25.2 6.2 2.9e-05 23.8 6.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 OPL33045.1 - 0.0001 22.1 6.7 0.00024 20.9 6.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL33045.1 - 0.0004 20.2 5.3 0.0004 20.2 5.3 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 OPL33045.1 - 0.0004 20.7 6.0 0.0012 19.2 6.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 OPL33045.1 - 0.0005 20.0 5.8 0.0014 18.6 5.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 OPL33045.1 - 0.055 13.6 4.5 0.15 12.2 4.5 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 OPL33045.1 - 0.11 12.2 3.0 0.15 11.9 0.7 2.4 2 1 0 2 2 2 0 RING-like zinc finger AAA_28 PF13521.6 OPL33046.1 - 2.3e-15 57.2 0.0 3.9e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF4111 PF13427.6 OPL33047.1 - 0.13 12.4 0.0 0.45 10.7 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4111) zf_C2H2_13 PF18508.1 OPL33047.1 - 4 7.1 5.2 8.7 6.0 0.1 2.8 2 0 0 2 2 2 0 Zinc finger domain zinc_ribbon_2 PF13240.6 OPL33047.1 - 6.8 6.5 8.1 19 5.1 0.0 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Ig_3 PF13927.6 OPL33048.1 - 2.5e-10 40.8 0.6 3.8e-07 30.6 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL33048.1 - 1e-07 32.0 0.4 9.6e-07 28.9 0.2 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 OPL33048.1 - 1.3e-06 28.6 0.2 0.00029 21.1 0.1 2.5 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 OPL33048.1 - 7e-06 26.0 0.0 0.00063 19.8 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_4 PF16680.5 OPL33048.1 - 0.0006 20.0 4.4 0.081 13.2 0.7 3.1 3 1 1 4 4 4 2 T-cell surface glycoprotein CD3 delta chain AvrPto PF11592.8 OPL33048.1 - 0.1 12.6 1.2 0.19 11.8 1.0 1.5 1 1 0 1 1 1 0 Central core of the bacterial effector protein AvrPto V-set PF07686.17 OPL33048.1 - 0.25 11.5 4.9 3.5 7.8 0.1 3.2 3 1 1 4 4 4 0 Immunoglobulin V-set domain Acyl-CoA_dh_1 PF00441.24 OPL33049.1 - 8.3e-25 87.7 0.0 1.1e-24 87.4 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 OPL33049.1 - 7.2e-15 55.0 0.0 1.2e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 OPL33049.1 - 3e-07 30.8 0.0 3.9e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HTH_Tnp_Tc3_1 PF11427.8 OPL33049.1 - 0.14 12.1 0.0 0.27 11.1 0.0 1.5 1 1 0 1 1 1 0 Tc3 transposase DndE PF08870.11 OPL33050.1 - 0.039 14.2 0.1 0.046 14.0 0.1 1.1 1 0 0 1 1 1 0 DNA sulphur modification protein DndE GMC_oxred_N PF00732.19 OPL33051.1 - 1.4e-51 175.6 0.0 2.1e-51 175.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 OPL33051.1 - 1.1e-33 116.8 0.0 1.8e-33 116.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase SAM_2 PF07647.17 OPL33052.1 - 8.3e-10 38.6 0.1 1.8e-09 37.6 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 OPL33052.1 - 8.3e-08 32.6 0.5 1.9e-07 31.4 0.5 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CABIT PF12736.7 OPL33052.1 - 2.2e-07 30.5 0.4 0.025 13.9 0.0 3.2 2 1 1 3 3 3 3 Cell-cycle sustaining, positive selection, Phage_term_smal PF05944.12 OPL33054.1 - 0.035 14.1 0.2 1.2 9.2 0.0 2.7 2 0 0 2 2 2 0 Phage small terminase subunit BIR PF00653.21 OPL33055.1 - 2e-26 92.5 7.3 4.4e-14 52.9 5.0 2.2 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain p450 PF00067.22 OPL33056.1 - 1.4e-23 83.4 0.1 1.5e-23 83.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M14 PF00246.24 OPL33057.1 - 9.9e-63 212.6 0.8 1.1e-62 212.5 0.8 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase BTB PF00651.31 OPL33058.1 - 2.9e-16 59.7 0.5 1.9e-15 57.0 0.1 2.5 1 1 1 2 2 2 1 BTB/POZ domain Ank_2 PF12796.7 OPL33058.1 - 1.3e-09 38.5 0.2 5.8e-05 23.6 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL33058.1 - 2.3e-07 31.2 0.5 2.8e-05 24.6 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL33058.1 - 0.00023 21.3 0.0 2.4 9.0 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 OPL33058.1 - 0.00063 20.0 0.1 1.8 9.0 0.0 3.0 1 1 0 2 2 2 2 Ankyrin repeats (many copies) BACK PF07707.15 OPL33058.1 - 0.0022 18.1 1.5 0.17 12.0 0.1 2.8 2 1 0 2 2 2 1 BTB And C-terminal Kelch Ank PF00023.30 OPL33058.1 - 0.024 15.1 0.0 2.9 8.5 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeat C1q PF00386.21 OPL33059.1 - 1.6e-17 63.9 0.1 2.1e-17 63.5 0.1 1.2 1 0 0 1 1 1 1 C1q domain TPR_2 PF07719.17 OPL33060.1 - 3.3e-23 79.9 16.0 6.1e-05 22.8 0.1 7.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 OPL33060.1 - 2e-17 62.2 20.7 2.7e-07 30.1 0.2 7.9 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 OPL33060.1 - 4.7e-15 55.0 3.1 0.00044 19.9 0.0 6.4 6 1 1 7 7 7 3 TPR repeat TPR_12 PF13424.6 OPL33060.1 - 2.4e-13 50.2 13.1 9.8e-07 29.0 0.1 6.3 2 2 5 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 OPL33060.1 - 2.3e-12 47.3 3.2 0.009 16.6 1.2 5.2 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 OPL33060.1 - 3.6e-11 42.3 2.9 1.5 9.3 0.0 6.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 OPL33060.1 - 7.5e-08 32.4 7.3 0.51 10.5 0.1 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 OPL33060.1 - 2e-07 31.2 9.3 1.8 9.6 0.2 7.2 6 2 3 9 9 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 OPL33060.1 - 7.1e-07 29.4 9.0 0.0066 16.6 1.3 3.7 3 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 OPL33060.1 - 9.4e-07 28.4 7.2 0.11 12.6 0.0 6.0 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 OPL33060.1 - 4.2e-06 26.8 3.6 12 6.5 0.1 6.6 7 0 0 7 7 6 0 Tetratricopeptide repeat NARP1 PF12569.8 OPL33060.1 - 1.2e-05 24.4 6.9 0.55 9.1 0.0 3.9 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 OPL33060.1 - 2.4e-05 24.8 12.1 0.0042 17.6 0.2 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat Com_YlbF PF06133.11 OPL33060.1 - 0.014 15.9 0.1 0.036 14.7 0.1 1.7 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA TPR_10 PF13374.6 OPL33060.1 - 0.17 11.8 5.0 99 3.0 0.0 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF5588 PF17826.1 OPL33060.1 - 0.34 9.8 1.7 19 4.0 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5588) TPR_6 PF13174.6 OPL33060.1 - 8.2 7.3 6.9 1.2e+02 3.6 0.2 5.1 6 0 0 6 6 4 0 Tetratricopeptide repeat MMR_HSR1 PF01926.23 OPL33061.1 - 5.8e-08 32.8 0.2 1.3e-07 31.7 0.2 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 OPL33061.1 - 1.8e-07 30.7 0.1 2.8e-07 30.1 0.1 1.3 1 0 0 1 1 1 1 Septin AIG1 PF04548.16 OPL33061.1 - 2.4e-06 27.0 2.1 3e-05 23.5 2.1 2.1 1 1 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 OPL33061.1 - 7.4e-06 26.1 0.4 0.11 12.6 0.0 2.4 1 1 1 2 2 2 2 Dynamin family AAA_29 PF13555.6 OPL33061.1 - 5.4e-05 22.8 0.0 0.00025 20.7 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.27 OPL33061.1 - 0.00073 20.1 0.2 0.0058 17.2 0.0 2.1 2 0 0 2 2 2 1 ABC transporter GTP_EFTU PF00009.27 OPL33061.1 - 0.0014 18.2 0.0 0.0031 17.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 OPL33061.1 - 0.0014 19.2 1.6 0.0034 17.9 1.6 2.0 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 OPL33061.1 - 0.0018 18.2 0.5 0.0097 15.8 0.5 2.1 1 1 0 1 1 1 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 OPL33061.1 - 0.0084 15.5 0.1 0.016 14.6 0.1 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family SMC_N PF02463.19 OPL33061.1 - 0.0095 15.4 0.0 0.022 14.2 0.0 1.7 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 OPL33061.1 - 0.012 15.8 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 OPL33061.1 - 0.024 13.7 0.0 0.039 13.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 OPL33061.1 - 0.034 14.3 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 OPL33061.1 - 0.037 13.8 0.2 0.078 12.8 0.2 1.7 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 OPL33061.1 - 0.044 14.2 0.0 0.16 12.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_21 PF13304.6 OPL33061.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system CLP1_P PF16575.5 OPL33061.1 - 0.089 12.6 1.0 1.3 8.8 0.0 2.7 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 OPL33061.1 - 0.12 12.0 0.0 0.35 10.5 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 OPL33061.1 - 0.12 12.9 0.0 0.26 11.8 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_22 PF13401.6 OPL33061.1 - 0.13 12.5 0.1 0.43 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain fn3 PF00041.21 OPL33062.1 - 0.018 15.4 0.0 0.042 14.2 0.0 1.7 1 0 0 1 1 1 0 Fibronectin type III domain zf-B_box PF00643.24 OPL33062.1 - 0.11 12.7 28.0 2.5 8.3 15.4 3.3 1 1 0 2 2 2 0 B-box zinc finger zf-MYST PF17772.1 OPL33062.1 - 6.2 6.5 10.7 1.2 8.8 1.3 2.7 2 0 0 2 2 2 0 MYST family zinc finger domain Somatomedin_B PF01033.17 OPL33063.1 - 4.1e-15 55.9 43.4 1.4e-07 31.7 20.2 2.9 1 1 1 2 2 2 2 Somatomedin B domain TMEM154 PF15102.6 OPL33063.1 - 0.0017 18.3 0.4 0.0032 17.4 0.4 1.5 1 0 0 1 1 1 1 TMEM154 protein family Protocadherin PF08374.11 OPL33063.1 - 0.0042 17.1 0.5 0.0071 16.3 0.5 1.4 1 0 0 1 1 1 1 Protocadherin EphA2_TM PF14575.6 OPL33063.1 - 0.018 15.9 0.1 0.066 14.1 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain O-antigen_lig PF13425.6 OPL33063.1 - 0.055 12.3 0.7 0.078 11.8 0.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SID-1_RNA_chan PF13965.6 OPL33063.1 - 0.11 10.9 2.9 0.16 10.4 2.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4834 PF16118.5 OPL33063.1 - 0.64 11.0 3.8 0.38 11.7 1.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) I-set PF07679.16 OPL33064.1 - 1.6e-45 153.1 0.6 7.6e-16 58.0 0.1 3.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33064.1 - 2.7e-40 136.8 6.2 4.6e-16 59.2 0.2 3.1 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 OPL33064.1 - 1e-25 89.9 2.8 1.5e-08 34.8 0.1 3.1 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 OPL33064.1 - 2.6e-24 85.2 1.3 1.4e-07 31.6 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 OPL33064.1 - 1.4e-17 63.8 7.0 4.7e-05 23.5 0.1 5.9 3 3 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 OPL33064.1 - 1.2e-07 31.7 1.2 0.011 15.8 0.0 3.3 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 OPL33064.1 - 5.2e-06 26.4 0.2 0.049 13.7 0.0 2.6 2 0 0 2 2 2 2 C17orf99 Ig domain Ig_6 PF18452.1 OPL33064.1 - 1.2e-05 24.7 0.0 0.067 12.8 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 OPL33064.1 - 1.3e-05 25.4 0.2 0.81 10.0 0.0 3.5 3 1 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 OPL33064.1 - 4.5e-05 23.8 0.5 0.038 14.4 0.0 3.5 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 OPL33064.1 - 0.0088 16.1 0.0 4.2 7.5 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain DUF2807 PF10988.8 OPL33064.1 - 0.095 12.5 0.1 1.3 8.8 0.0 2.5 2 1 0 2 2 2 0 Putative auto-transporter adhesin, head GIN domain Ig_3 PF13927.6 OPL33065.1 - 7.8e-12 45.6 0.1 1.2e-08 35.4 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL33065.1 - 1.2e-11 44.5 0.0 4.1e-05 23.6 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL33065.1 - 5.2e-08 33.1 0.2 0.002 18.4 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL33065.1 - 2e-05 24.6 0.1 0.00031 20.9 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 OPL33065.1 - 0.0014 18.8 0.3 0.068 13.3 0.3 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 OPL33065.1 - 0.038 14.0 0.0 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 OPL33065.1 - 0.11 12.6 0.1 0.24 11.5 0.0 1.6 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Ig_3 PF13927.6 OPL33066.1 - 7.6e-09 36.1 0.1 9.9e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL33066.1 - 2e-07 31.2 0.0 2.3e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL33066.1 - 3.2e-06 27.1 0.0 5.3e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 OPL33066.1 - 0.00032 20.8 0.0 0.0016 18.5 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 OPL33066.1 - 0.0045 17.1 0.5 0.029 14.6 0.1 2.0 1 1 1 2 2 2 1 Immunoglobulin V-set domain COR PF16095.5 OPL33067.1 - 1e-12 48.3 1.4 1e-12 48.3 1.4 2.7 3 1 0 3 3 3 1 C-terminal of Roc, COR, domain Death PF00531.22 OPL33067.1 - 1e-07 32.0 1.9 3.7e-05 23.8 0.4 3.0 2 1 0 2 2 2 2 Death domain DUF1786 PF08735.10 OPL33067.1 - 0.072 12.4 0.2 0.27 10.5 0.1 1.9 2 0 0 2 2 2 0 Putative pyruvate format-lyase activating enzyme (DUF1786) Y_phosphatase PF00102.27 OPL33068.1 - 1.1e-61 208.5 1.8 1e-45 156.1 0.1 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 OPL33068.1 - 0.00024 20.9 0.3 0.014 15.2 0.0 2.8 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Vps51 PF08700.11 OPL33071.1 - 0.0039 17.3 10.3 0.012 15.7 4.4 3.7 2 1 1 3 3 3 1 Vps51/Vps67 DUF4494 PF14902.6 OPL33071.1 - 0.0039 17.0 2.2 0.0075 16.1 2.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4494) Fzo_mitofusin PF04799.13 OPL33071.1 - 0.012 15.2 4.7 0.033 13.8 4.7 1.8 1 1 0 1 1 1 0 fzo-like conserved region Exonuc_VII_L PF02601.15 OPL33071.1 - 0.014 15.0 2.0 0.02 14.5 2.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med3 PF11593.8 OPL33071.1 - 0.067 12.4 3.0 0.1 11.8 3.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF2203 PF09969.9 OPL33071.1 - 0.077 13.7 0.7 0.077 13.7 0.7 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fib_alpha PF08702.10 OPL33071.1 - 0.12 12.6 10.2 7.4 6.8 8.0 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Mt_ATP-synt_D PF05873.12 OPL33071.1 - 0.13 12.1 4.2 0.2 11.5 2.6 2.0 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) PHD_2 PF13831.6 OPL33071.1 - 0.18 11.4 0.2 0.33 10.6 0.2 1.4 1 0 0 1 1 1 0 PHD-finger DUF1664 PF07889.12 OPL33071.1 - 0.19 11.7 10.6 6.4 6.8 10.6 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Apolipoprotein PF01442.18 OPL33071.1 - 0.29 11.0 4.2 0.57 10.0 4.2 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain HSBP1 PF06825.12 OPL33071.1 - 0.44 10.4 8.6 3.7 7.5 0.4 3.8 4 0 0 4 4 3 0 Heat shock factor binding protein 1 ABC_tran_CTD PF16326.5 OPL33071.1 - 0.47 10.7 6.9 0.97 9.7 0.5 2.9 1 1 2 3 3 3 0 ABC transporter C-terminal domain DUF5082 PF16888.5 OPL33071.1 - 0.76 10.1 12.2 0.29 11.4 8.4 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Phasin PF05597.11 OPL33071.1 - 0.87 9.6 6.1 1.5 8.9 5.0 1.9 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) zf-RING_9 PF13901.6 OPL33071.1 - 0.92 9.4 6.0 0.67 9.9 1.2 2.3 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Allexi_40kDa PF05549.11 OPL33071.1 - 1.2 8.6 10.0 0.3 10.6 5.4 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein Snapin_Pallidin PF14712.6 OPL33071.1 - 1.7 9.2 9.0 1.5 9.3 5.8 2.3 1 1 1 2 2 2 0 Snapin/Pallidin DUF948 PF06103.11 OPL33071.1 - 2 8.7 6.3 12 6.2 5.0 2.5 2 1 0 2 2 1 0 Bacterial protein of unknown function (DUF948) HR1 PF02185.16 OPL33071.1 - 2.4 8.3 9.0 2.8 8.1 0.9 3.4 1 1 2 3 3 3 0 Hr1 repeat Baculo_PEP_C PF04513.12 OPL33071.1 - 4.2 7.4 7.4 11 6.0 5.8 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YojJ PF10372.9 OPL33071.1 - 4.2 7.5 6.1 1.2 9.3 1.3 2.7 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus Shugoshin_N PF07558.11 OPL33071.1 - 7.5 6.5 7.6 1.6 8.7 0.2 3.1 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region WSC PF01822.19 OPL33072.1 - 0.031 14.4 0.0 0.042 14.0 0.0 1.2 1 0 0 1 1 1 0 WSC domain Pkinase PF00069.25 OPL33073.1 - 7.7e-59 199.2 0.0 4.5e-58 196.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL33073.1 - 1e-41 143.0 0.0 1.5e-41 142.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 OPL33073.1 - 8.5e-10 38.4 0.0 1.5e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 OPL33073.1 - 0.0014 18.0 0.1 0.0026 17.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 OPL33073.1 - 0.11 11.4 0.1 0.11 11.4 0.1 2.1 3 0 0 3 3 3 0 Haspin like kinase domain DTC PF18102.1 OPL33074.1 - 9.1e-40 135.9 0.0 1.2e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Deltex C-terminal domain zf-C3HC4_2 PF13923.6 OPL33074.1 - 2.7e-09 36.7 13.9 3.9e-09 36.2 13.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 OPL33074.1 - 3.6e-08 33.6 11.6 5.3e-08 33.1 11.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 OPL33074.1 - 7e-08 32.2 13.2 1.1e-07 31.6 13.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 OPL33074.1 - 2.4e-06 27.4 10.5 3.6e-06 26.8 10.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 OPL33074.1 - 2.7e-06 27.3 8.4 3.5e-06 26.9 5.3 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 OPL33074.1 - 6.2e-06 26.0 9.1 8.6e-06 25.5 9.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 OPL33074.1 - 5.1e-05 23.1 5.9 8.5e-05 22.4 5.9 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 OPL33074.1 - 0.00027 21.1 7.4 0.00045 20.4 7.4 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 OPL33074.1 - 0.00033 20.7 7.5 0.00051 20.1 7.5 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 OPL33074.1 - 0.0016 18.2 10.0 0.0025 17.6 10.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 OPL33074.1 - 0.0026 17.5 7.1 0.0044 16.8 7.1 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 OPL33074.1 - 0.013 15.6 10.8 0.04 14.1 11.0 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Glyco_hydro_56 PF01630.18 OPL33074.1 - 0.039 13.0 0.3 0.082 11.9 0.1 1.5 1 1 1 2 2 2 0 Hyaluronidase Adap_comp_sub PF00928.21 OPL33075.1 - 1.1e-33 116.7 0.1 1.6e-33 116.2 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family DUF3658 PF12395.8 OPL33076.1 - 0.045 13.7 0.1 0.066 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function Ank_2 PF12796.7 OPL33077.1 - 3.3e-33 114.1 3.7 1.1e-09 38.7 0.2 4.2 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 OPL33077.1 - 1.6e-31 107.4 10.3 5e-05 23.5 0.6 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 OPL33077.1 - 1.3e-29 102.2 5.0 2e-07 31.4 0.2 5.6 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 OPL33077.1 - 3.3e-27 94.2 7.9 4.1e-06 27.0 0.0 5.2 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL33077.1 - 7.5e-26 87.4 3.5 0.0009 19.5 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat Xan_ur_permease PF00860.20 OPL33078.1 - 2.7e-06 26.3 0.1 2.9e-06 26.2 0.1 1.0 1 0 0 1 1 1 1 Permease family Myco_arth_vir_N PF09610.10 OPL33078.1 - 9.6 6.4 6.6 0.78 9.9 1.8 1.6 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Xan_ur_permease PF00860.20 OPL33079.1 - 0.0022 16.8 0.3 0.0029 16.4 0.3 1.2 1 0 0 1 1 1 1 Permease family Nif11 PF07862.11 OPL33079.1 - 0.082 13.2 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Nif11 domain Hydrolase PF00702.26 OPL33080.1 - 2.9e-14 53.9 0.0 3.7e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 OPL33080.1 - 5.8e-14 52.9 0.0 7.9e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 OPL33080.1 - 2.4e-06 27.2 0.0 3.7e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.6 OPL33080.1 - 0.0064 16.6 0.0 0.62 10.1 0.0 2.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 OPL33080.1 - 0.052 13.1 0.0 0.08 12.5 0.0 1.3 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_3 PF08282.12 OPL33080.1 - 0.054 13.2 0.0 0.14 11.9 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase ACT_7 PF13840.6 OPL33080.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 ACT domain Ank_4 PF13637.6 OPL33081.1 - 6.3e-20 71.3 0.0 2.3e-09 37.6 0.0 2.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL33081.1 - 8.4e-15 55.1 0.0 2.6e-06 27.9 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 OPL33081.1 - 2e-14 52.2 0.0 3e-05 24.1 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 OPL33081.1 - 2.6e-13 49.9 0.0 1.7e-06 28.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 OPL33081.1 - 6.4e-11 42.2 0.0 8.3e-05 22.9 0.0 3.1 4 0 0 4 4 4 2 Ankyrin repeat TMCO5 PF14992.6 OPL33082.1 - 0.0017 18.0 4.9 0.0033 17.1 4.9 1.5 1 1 0 1 1 1 1 TMCO5 family SlyX PF04102.12 OPL33082.1 - 0.0018 18.8 8.4 0.0038 17.8 2.4 2.3 1 1 1 2 2 2 1 SlyX TTc_toxin_rep PF18807.1 OPL33082.1 - 0.058 13.2 0.4 0.28 11.0 0.1 2.1 2 0 0 2 2 2 0 Tripartite Tc toxins repeat Cdh1_DBD_1 PF18196.1 OPL33082.1 - 0.06 13.7 1.6 0.091 13.1 1.6 1.3 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 EspF PF04806.12 OPL33082.1 - 0.17 12.3 1.2 1.1 9.7 0.7 2.2 2 0 0 2 2 2 0 EspF protein repeat fn3 PF00041.21 OPL33083.1 - 1.2e-05 25.6 0.1 0.0085 16.4 0.1 3.5 2 1 0 2 2 2 1 Fibronectin type III domain Herpes_UL37_1 PF03970.13 OPL33083.1 - 0.15 11.2 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL37 tegument protein Stevor PF17410.2 OPL33083.1 - 0.38 10.3 2.8 0.76 9.3 2.8 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame CBM_14 PF01607.24 OPL33084.1 - 0.054 13.7 0.4 8.8 6.6 0.1 2.7 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain Baculo_VP91_N PF08475.10 OPL33084.1 - 0.82 9.3 4.3 0.63 9.7 0.6 2.1 1 1 1 2 2 2 0 Viral capsid protein 91 N-terminal Rax2 PF12768.7 OPL33086.1 - 0.0027 17.2 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Neurensin PF14927.6 OPL33086.1 - 0.0047 16.6 0.1 0.0069 16.1 0.1 1.3 1 0 0 1 1 1 1 Neurensin Tweety PF04906.13 OPL33086.1 - 0.0058 15.4 0.7 0.075 11.7 0.0 2.0 2 0 0 2 2 2 1 Tweety Syndecan PF01034.20 OPL33086.1 - 0.088 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain EphA2_TM PF14575.6 OPL33086.1 - 0.088 13.7 0.1 0.17 12.8 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 OPL33086.1 - 0.13 12.6 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Shisa PF13908.6 OPL33086.1 - 0.24 11.6 0.1 0.24 11.6 0.1 2.0 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Mucin15 PF15672.5 OPL33086.1 - 6 6.3 16.4 0.12 11.9 1.5 2.2 1 1 1 2 2 2 0 Cell-membrane associated Mucin15 Nop PF01798.18 OPL33087.1 - 2.1e-81 272.8 0.1 2.1e-81 272.8 0.1 2.5 2 1 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 OPL33087.1 - 3.8e-21 75.3 0.4 3.8e-21 75.3 0.4 3.1 3 0 0 3 3 3 1 NOP5NT (NUC127) domain EVE PF01878.18 OPL33087.1 - 4 7.4 10.1 40 4.2 10.1 2.4 1 1 0 1 1 1 0 EVE domain SAPS PF04499.15 OPL33087.1 - 9.6 4.9 15.5 17 4.0 15.5 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ank_2 PF12796.7 OPL33089.1 - 5.2e-93 305.8 34.0 2.5e-16 60.0 0.3 7.4 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL33089.1 - 9.3e-81 265.2 24.2 2.6e-10 40.6 0.1 11.2 3 1 10 13 13 13 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL33089.1 - 1.6e-77 246.1 10.8 7.9e-05 22.8 0.0 15.4 15 0 0 15 15 15 13 Ankyrin repeat Ank PF00023.30 OPL33089.1 - 1.6e-75 246.5 24.1 6.3e-06 26.4 0.2 15.2 13 1 2 15 15 15 14 Ankyrin repeat Ank_5 PF13857.6 OPL33089.1 - 7.2e-72 236.5 24.4 6.5e-11 42.3 0.1 12.1 1 1 13 14 14 14 13 Ankyrin repeats (many copies) DUF3447 PF11929.8 OPL33089.1 - 0.69 9.9 5.1 15 5.6 0.1 4.9 4 1 1 5 5 5 0 Domain of unknown function (DUF3447) Ion_trans PF00520.31 OPL33091.1 - 0.032 13.4 0.8 0.039 13.2 0.8 1.1 1 0 0 1 1 1 0 Ion transport protein ADPrib_exo_Tox PF03496.14 OPL33092.1 - 0.02 14.2 1.1 0.089 12.1 0.1 2.2 2 0 0 2 2 2 0 ADP-ribosyltransferase exoenzyme Arylesterase PF01731.20 OPL33092.1 - 0.094 12.9 0.0 6.1 7.1 0.0 2.6 1 1 1 2 2 2 0 Arylesterase SBBP PF06739.11 OPL33092.1 - 0.097 12.7 0.0 0.4 10.7 0.0 2.2 2 0 0 2 2 2 0 Beta-propeller repeat Fibrinogen_C PF00147.18 OPL33093.1 - 1.2e-66 224.7 6.3 1.5e-66 224.4 6.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain AGTRAP PF06396.11 OPL33094.1 - 1.1e-08 34.9 1.4 1.6e-08 34.5 1.0 1.5 1 1 1 2 2 2 1 Angiotensin II, type I receptor-associated protein (AGTRAP) Baculo_PEP_C PF04513.12 OPL33096.1 - 0.00098 19.2 2.5 0.0013 18.7 2.5 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus FAM184 PF15665.5 OPL33096.1 - 0.005 16.7 1.3 0.0067 16.2 1.3 1.1 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B EzrA PF06160.12 OPL33096.1 - 0.015 13.5 0.6 0.02 13.1 0.6 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Syntaxin-6_N PF09177.11 OPL33096.1 - 0.015 15.8 0.7 0.021 15.4 0.7 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF1722 PF08349.11 OPL33096.1 - 0.015 15.5 0.2 0.023 15.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) Med26 PF08711.11 OPL33096.1 - 0.02 14.9 0.5 0.052 13.6 0.3 1.8 1 1 0 1 1 1 0 TFIIS helical bundle-like domain SesA PF17107.5 OPL33096.1 - 0.023 14.9 1.2 0.038 14.2 1.2 1.3 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases IFT57 PF10498.9 OPL33096.1 - 0.024 13.6 2.4 0.029 13.4 2.4 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 OPL33096.1 - 0.042 12.7 1.0 0.05 12.5 1.0 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4618 PF15397.6 OPL33096.1 - 0.061 12.7 2.6 0.12 11.7 2.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) RmuC PF02646.16 OPL33096.1 - 0.063 12.4 2.8 2.9 7.0 0.3 2.0 1 1 1 2 2 2 0 RmuC family Pannexin_like PF12534.8 OPL33096.1 - 0.066 12.3 0.6 0.075 12.1 0.6 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 TMPIT PF07851.13 OPL33096.1 - 0.067 12.4 0.7 0.088 12.0 0.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein Pou PF00157.17 OPL33096.1 - 0.078 13.0 0.1 0.17 11.9 0.1 1.5 1 1 0 1 1 1 0 Pou domain - N-terminal to homeobox domain Fib_alpha PF08702.10 OPL33096.1 - 0.13 12.5 2.1 0.18 12.0 2.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family XhlA PF10779.9 OPL33096.1 - 0.16 12.2 2.1 7.5 6.8 1.1 2.7 1 1 1 2 2 2 0 Haemolysin XhlA DUF948 PF06103.11 OPL33096.1 - 0.32 11.3 4.3 1.4 9.2 3.7 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Tweety PF04906.13 OPL33096.1 - 0.43 9.2 4.3 0.18 10.4 0.7 1.8 1 1 1 2 2 2 0 Tweety KxDL PF10241.9 OPL33096.1 - 0.6 10.4 4.1 7.8 6.9 0.4 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein Conotoxin PF02950.17 OPL33097.1 - 3.4 8.7 5.8 5.1 8.2 0.0 3.3 3 1 0 3 3 3 0 Conotoxin BIR PF00653.21 OPL33098.1 - 7.2e-10 39.4 2.3 5.6e-08 33.3 0.1 2.3 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 OPL33098.1 - 0.19 11.8 0.1 0.19 11.8 0.1 1.8 1 1 1 2 2 2 0 C3HC zinc finger-like LigB PF02900.18 OPL33099.1 - 4.6e-08 32.5 0.0 6.5e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Memo PF01875.17 OPL33099.1 - 0.16 11.1 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Memo-like protein AAA_23 PF13476.6 OPL33101.1 - 4.1e-16 60.1 0.5 4.1e-16 60.1 0.5 1.9 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 OPL33101.1 - 1.3e-14 54.2 0.6 1.8e-14 53.7 0.6 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 OPL33101.1 - 2.9e-09 37.1 0.6 2.9e-09 37.1 0.6 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 OPL33101.1 - 0.0012 18.5 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 OPL33101.1 - 0.0013 18.7 0.4 0.0013 18.7 0.4 1.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF2075 PF09848.9 OPL33101.1 - 0.004 16.4 0.4 0.0068 15.7 0.4 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) RsgA_GTPase PF03193.16 OPL33101.1 - 0.02 14.8 0.1 0.028 14.3 0.1 1.2 1 0 0 1 1 1 0 RsgA GTPase FtsK_SpoIIIE PF01580.18 OPL33101.1 - 0.03 13.7 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.27 OPL33101.1 - 0.035 14.6 0.4 0.052 14.1 0.4 1.5 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 OPL33101.1 - 0.039 13.2 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 OPL33101.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HBM PF16591.5 OPL33102.1 - 0.00033 20.2 0.5 0.00035 20.1 0.5 1.0 1 0 0 1 1 1 1 Helical bimodular sensor domain Fib_alpha PF08702.10 OPL33102.1 - 0.026 14.7 2.7 0.13 12.4 1.8 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3213 PF11491.8 OPL33102.1 - 0.031 14.4 2.0 3.7 7.8 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3213) Vps52 PF04129.12 OPL33102.1 - 0.037 12.8 1.2 0.047 12.4 1.2 1.1 1 0 0 1 1 1 0 Vps52 / Sac2 family DUF5446 PF17522.2 OPL33102.1 - 0.075 13.2 0.9 0.075 13.2 0.9 2.2 1 1 0 2 2 2 0 Family of unknown function (DUF5446) TMCO5 PF14992.6 OPL33102.1 - 0.085 12.4 5.3 0.089 12.4 5.3 1.1 1 0 0 1 1 1 0 TMCO5 family XhlA PF10779.9 OPL33102.1 - 0.6 10.4 5.8 0.31 11.3 3.0 1.8 2 0 0 2 2 2 0 Haemolysin XhlA C1q PF00386.21 OPL33103.1 - 3.6e-21 75.7 0.0 4.5e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL33103.1 - 0.0074 16.2 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 BclA C-terminal domain Podoplanin PF05808.11 OPL33105.1 - 0.0045 17.1 3.0 0.0053 16.9 3.0 1.3 1 0 0 1 1 1 1 Podoplanin DUF4448 PF14610.6 OPL33105.1 - 0.089 12.6 0.1 0.095 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) LRR19-TM PF15176.6 OPL33105.1 - 0.1 12.6 0.8 0.16 12.0 0.8 1.3 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Marek_A PF02124.15 OPL33105.1 - 0.16 11.8 2.2 0.2 11.5 2.2 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A SKG6 PF08693.10 OPL33105.1 - 0.34 10.4 21.2 0.056 12.9 16.9 2.0 1 1 1 2 2 2 0 Transmembrane alpha-helix domain Shisa PF13908.6 OPL33105.1 - 1.3 9.2 2.9 1.6 8.9 2.9 1.3 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator I-set PF07679.16 OPL33107.1 - 8.3e-14 51.4 0.0 5.6e-10 39.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33107.1 - 1.3e-09 38.5 3.0 6.6e-06 26.6 0.2 2.7 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 OPL33107.1 - 2.2e-06 27.9 0.1 0.016 15.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL33107.1 - 7e-06 26.1 2.8 0.0047 17.1 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 OPL33107.1 - 3.3e-05 24.0 0.2 0.00066 19.8 0.1 2.5 1 1 1 2 2 2 1 Immunoglobulin V-set domain HYR PF02494.16 OPL33108.1 - 0.008 16.5 0.4 0.049 14.0 0.1 2.4 1 1 1 2 2 2 1 HYR domain V-set PF07686.17 OPL33108.1 - 0.057 13.6 1.6 0.1 12.8 0.1 2.0 2 1 0 2 2 2 0 Immunoglobulin V-set domain DUF5011 PF16403.5 OPL33108.1 - 0.065 13.4 0.1 0.065 13.4 0.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5011) DUF3768 PF12599.8 OPL33109.1 - 0.057 13.4 0.1 2.5 8.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3768) CRAL_TRIO_N PF03765.15 OPL33110.1 - 7.8e-05 22.8 1.5 0.00013 22.1 1.5 1.5 1 1 0 1 1 1 1 CRAL/TRIO, N-terminal domain Blt1_C PF17183.4 OPL33110.1 - 0.075 12.6 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Get5 carboxyl domain DUF2462 PF09495.10 OPL33110.1 - 0.078 13.7 0.1 0.12 13.2 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2462) Ephrin_rec_like PF07699.13 OPL33111.1 - 0.01 15.6 5.8 0.01 15.6 5.8 2.9 2 0 0 2 2 2 0 Putative ephrin-receptor like PD-C2-AF1 PF09310.10 OPL33111.1 - 0.098 12.1 0.5 7.5 5.9 0.0 2.1 2 0 0 2 2 2 0 POU domain, class 2, associating factor 1 Annexin PF00191.20 OPL33112.1 - 1.6e-82 271.5 4.1 2e-23 82.2 0.0 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 OPL33112.1 - 0.0013 18.6 1.6 6.2 6.8 0.2 3.4 3 0 0 3 3 3 3 Myb DNA-binding like Sigma70_ner PF04546.13 OPL33112.1 - 0.0016 18.4 2.3 0.0024 17.8 2.3 1.3 1 0 0 1 1 1 1 Sigma-70, non-essential region Mer2 PF09074.10 OPL33113.1 - 0.011 15.5 3.1 0.011 15.5 3.1 2.7 4 0 0 4 4 4 0 Mer2 Phe_ZIP PF08916.11 OPL33113.1 - 0.059 14.1 0.4 2 9.2 0.0 3.4 3 0 0 3 3 3 0 Phenylalanine zipper TRADD_N PF09034.10 OPL33113.1 - 4.1 7.5 7.6 0.31 11.1 0.2 3.0 4 0 0 4 4 4 0 TRADD, N-terminal domain COR PF16095.5 OPL33115.1 - 2.5e-18 66.6 0.4 6.2e-18 65.3 0.4 1.6 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain HSP70 PF00012.20 OPL33116.1 - 9.9e-12 43.8 1.1 4.7e-10 38.3 1.1 2.7 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL33116.1 - 0.0048 15.8 0.6 0.11 11.3 0.1 2.7 2 2 0 2 2 2 1 MreB/Mbl protein pRN1_helical PF13010.6 OPL33116.1 - 0.11 12.4 0.7 0.92 9.5 0.2 2.5 1 1 1 2 2 2 0 Primase helical domain EGF PF00008.27 OPL33118.1 - 4e-32 110.1 70.4 4.5e-08 33.3 11.6 4.3 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 OPL33118.1 - 3.1e-27 94.2 60.6 4.2e-07 30.4 7.9 5.5 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_CA PF07645.15 OPL33118.1 - 7e-16 58.2 67.2 9.6e-05 22.5 10.7 4.1 3 1 1 4 4 4 4 Calcium-binding EGF domain FXa_inhibition PF14670.6 OPL33118.1 - 3.2e-08 33.7 56.6 0.0063 16.8 10.0 4.7 1 1 3 4 4 4 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 OPL33118.1 - 7.2e-06 26.1 67.3 0.15 12.3 9.1 5.0 3 2 1 4 4 4 4 EGF domain cEGF PF12662.7 OPL33118.1 - 0.00029 20.7 70.3 0.0082 16.1 1.4 8.2 6 2 1 7 7 7 4 Complement Clr-like EGF-like EGF_2 PF07974.13 OPL33118.1 - 0.0004 20.7 72.2 0.13 12.7 11.3 4.2 4 0 0 4 4 4 4 EGF-like domain Plasmod_Pvs28 PF06247.11 OPL33118.1 - 0.022 15.0 59.8 0.16 12.3 11.9 4.2 4 0 0 4 4 4 0 Pvs28 EGF domain Laminin_EGF PF00053.24 OPL33118.1 - 0.076 13.2 56.3 2 8.6 8.9 4.4 1 1 3 4 4 4 0 Laminin EGF domain TROVE PF05731.11 OPL33119.1 - 3.7e-62 210.8 0.0 1.1e-31 110.4 0.0 3.2 1 1 1 2 2 2 2 TROVE domain VWA_2 PF13519.6 OPL33119.1 - 0.00076 20.1 0.0 0.0019 18.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain TROVE PF05731.11 OPL33120.1 - 7.6e-39 134.0 2.3 8.4e-37 127.2 1.2 2.9 1 1 1 2 2 2 2 TROVE domain AlbA_2 PF04326.14 OPL33121.1 - 7.3e-11 42.5 0.0 4.7e-10 39.8 0.0 2.1 1 1 0 1 1 1 1 Putative DNA-binding domain Pkinase_Tyr PF07714.17 OPL33122.1 - 2.3e-32 112.3 0.0 3e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 OPL33122.1 - 7.1e-12 45.3 0.0 8.7e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DDE_Tnp_1_7 PF13843.6 OPL33123.1 - 1.9e-17 63.6 0.0 1.9e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 Transposase IS4 DUF749 PF05370.11 OPL33124.1 - 0.0042 17.1 0.2 0.0042 17.1 0.2 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF749) zf-C3HC4_5 PF17121.5 OPL33124.1 - 0.18 11.7 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TENA_THI-4 PF03070.16 OPL33125.1 - 5.7e-08 32.8 0.0 7.3e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Sugar_tr PF00083.24 OPL33126.1 - 2.2e-11 43.3 4.0 2.6e-11 43.1 4.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1604 PF07713.13 OPL33126.1 - 2.6 7.9 7.8 8.1 6.3 2.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1604) Pacs-1 PF10254.9 OPL33127.1 - 8.9e-54 183.0 3.3 9.7e-54 182.9 3.3 1.0 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein DUF2924 PF11149.8 OPL33127.1 - 0.0046 17.3 0.1 0.0058 17.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2924) GMC_oxred_C PF05199.13 OPL33129.1 - 3.8e-38 131.2 0.1 4.9e-38 130.9 0.1 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 OPL33130.1 - 1.5e-15 57.4 0.0 1.7e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Sulfotransfer_1 PF00685.27 OPL33131.1 - 0.00014 21.4 0.1 0.00021 20.9 0.1 1.5 1 1 0 1 1 1 1 Sulfotransferase domain XendoU PF09412.10 OPL33132.1 - 1.7e-92 309.4 0.5 2.1e-92 309.1 0.5 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU Glyco_hydro_130 PF04041.13 OPL33132.1 - 0.0045 16.0 0.1 0.0071 15.3 0.1 1.2 1 0 0 1 1 1 1 beta-1,4-mannooligosaccharide phosphorylase Macro PF01661.21 OPL33134.1 - 1.5e-17 63.7 0.0 2.6e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Macro domain Macro PF01661.21 OPL33135.1 - 8.7e-15 54.8 0.4 4.9e-08 33.0 0.4 2.8 2 0 0 2 2 2 2 Macro domain WWE PF02825.20 OPL33135.1 - 0.029 15.0 0.0 0.087 13.4 0.0 1.9 1 0 0 1 1 1 0 WWE domain PARP PF00644.20 OPL33136.1 - 1.9e-19 70.0 0.8 5.3e-18 65.3 0.8 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.10 OPL33136.1 - 0.0062 16.3 0.0 0.0079 16.0 0.0 1.2 1 0 0 1 1 1 1 Exotoxin A catalytic SH3_2 PF07653.17 OPL33137.1 - 5.3e-21 74.1 1.1 2e-09 37.0 0.2 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 OPL33137.1 - 6.9e-21 73.9 0.0 8.5e-10 38.3 0.0 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 OPL33137.1 - 3.1e-19 68.3 0.1 4.1e-09 35.9 0.0 2.2 2 0 0 2 2 2 2 SH3 domain SH3_10 PF17902.1 OPL33137.1 - 0.00067 19.7 0.0 0.67 10.1 0.0 2.2 2 0 0 2 2 2 2 SH3 domain CFIA_Pcf11 PF11526.8 OPL33137.1 - 0.0037 17.7 1.8 0.0092 16.5 1.8 1.5 1 0 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 RTT107_BRCT_6 PF16771.5 OPL33137.1 - 0.058 13.6 0.1 0.093 12.9 0.1 1.4 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Peptidase_S41 PF03572.18 OPL33137.1 - 0.072 12.7 0.7 0.11 12.0 0.7 1.4 1 1 0 1 1 1 0 Peptidase family S41 TGF_beta PF00019.20 OPL33138.1 - 6.6e-25 88.1 2.6 8.2e-25 87.8 0.6 2.1 2 0 0 2 2 2 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 OPL33138.1 - 1.1e-11 44.9 2.2 1.9e-11 44.2 2.2 1.3 1 0 0 1 1 1 1 TGF-beta propeptide fn3 PF00041.21 OPL33140.1 - 0.0015 18.9 1.1 0.0023 18.3 1.1 1.2 1 0 0 1 1 1 1 Fibronectin type III domain SdrD_B PF17210.3 OPL33140.1 - 0.1 12.8 0.1 0.53 10.5 0.1 1.8 1 1 1 2 2 2 0 SdrD B-like domain CARD PF00619.21 OPL33142.1 - 5.9e-21 74.3 5.7 9.9e-11 41.5 0.7 2.5 2 0 0 2 2 2 2 Caspase recruitment domain CARD_2 PF16739.5 OPL33142.1 - 3.5e-16 59.0 2.3 1.5e-07 31.3 0.1 2.9 3 0 0 3 3 3 2 Caspase recruitment domain COR PF16095.5 OPL33142.1 - 2e-13 50.6 0.8 4.6e-13 49.4 0.1 2.0 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain Death PF00531.22 OPL33142.1 - 0.0005 20.2 0.9 0.0013 18.9 0.1 2.1 2 0 0 2 2 2 1 Death domain IL10 PF00726.17 OPL33142.1 - 0.034 13.6 0.3 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 Interleukin 10 Ephrin_rec_like PF07699.13 OPL33143.1 - 0.0025 17.5 3.6 1.3 8.8 0.4 2.6 2 0 0 2 2 2 2 Putative ephrin-receptor like MBR1 PF17058.5 OPL33143.1 - 0.021 15.1 2.5 0.032 14.5 2.5 1.4 1 0 0 1 1 1 0 Mitochondrial biogenesis regulation protein 1 Peptidase_S49_N PF08496.10 OPL33143.1 - 2.4 8.2 11.4 3.8 7.6 11.4 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal V_ATPase_I PF01496.19 OPL33143.1 - 3 5.7 8.2 3.4 5.5 8.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GCD14 PF08704.10 OPL33143.1 - 3.4 7.3 6.4 5.8 6.5 6.4 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit YabA PF06156.13 OPL33143.1 - 9.7 6.9 13.3 2.2 9.0 9.2 1.9 2 0 0 2 2 2 0 Initiation control protein YabA fn3 PF00041.21 OPL33144.1 - 6.9e-06 26.3 5.7 0.45 10.9 0.0 4.7 4 0 0 4 4 4 3 Fibronectin type III domain CheC PF04509.12 OPL33144.1 - 0.06 13.3 1.5 1.6 8.7 0.1 2.9 3 0 0 3 3 3 0 CheC-like family Y_phosphatase PF00102.27 OPL33147.1 - 5.1e-21 75.3 4.5 4.9e-10 39.4 0.3 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase RNA_pol_Rpb5_C PF01191.19 OPL33147.1 - 0.11 12.3 0.1 0.65 9.9 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain Nucleoside_tran PF01733.18 OPL33148.1 - 3.2e-40 138.4 0.4 3.7e-40 138.2 0.4 1.0 1 0 0 1 1 1 1 Nucleoside transporter DUF2070 PF09843.9 OPL33148.1 - 0.0029 16.0 1.5 0.0034 15.8 1.5 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) Nucleoside_tran PF01733.18 OPL33149.1 - 4.4e-14 52.6 2.2 4.4e-14 52.6 2.2 2.0 2 0 0 2 2 2 1 Nucleoside transporter SP_C-Propep PF08999.10 OPL33149.1 - 0.16 11.7 2.9 0.55 10.1 0.0 2.8 3 0 0 3 3 3 0 Surfactant protein C, N terminal propeptide Ldl_recept_b PF00058.17 OPL33150.1 - 3e-21 75.6 0.2 1.4e-08 35.0 0.1 3.7 4 0 0 4 4 4 3 Low-density lipoprotein receptor repeat class B DUF5050 PF16472.5 OPL33150.1 - 2.6e-07 30.2 0.1 4.3e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5050) SGL PF08450.12 OPL33150.1 - 0.0014 18.3 0.3 0.17 11.5 0.3 2.7 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 OPL33150.1 - 0.088 13.0 0.1 3.4 7.9 0.0 2.9 2 1 0 2 2 2 0 Arylesterase Pkinase_Tyr PF07714.17 OPL33151.1 - 0.00031 20.1 0.0 0.00048 19.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 OPL33151.1 - 0.049 13.0 0.1 0.17 11.3 0.0 1.8 1 1 1 2 2 2 0 Protein kinase domain Papo_T_antigen PF02380.15 OPL33151.1 - 0.074 13.2 0.9 0.11 12.6 0.9 1.2 1 0 0 1 1 1 0 T-antigen specific domain Pkinase_Tyr PF07714.17 OPL33152.1 - 4e-67 226.2 0.0 4.8e-67 226.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 OPL33152.1 - 1.8e-29 102.9 0.0 2e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 OPL33152.1 - 0.027 13.8 0.0 0.035 13.4 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 OPL33152.1 - 0.028 13.4 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Ig_2 PF13895.6 OPL33154.1 - 3.1e-14 53.1 2.5 1.7e-07 31.5 0.5 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 OPL33154.1 - 2e-13 50.7 4.3 8.5e-06 26.3 0.3 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL33154.1 - 1.3e-06 28.4 5.3 0.0016 18.4 0.5 3.8 2 2 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 OPL33154.1 - 0.0076 16.4 8.4 0.76 10.0 1.0 3.6 2 2 0 2 2 2 2 Immunoglobulin domain Ig_C17orf99 PF17736.1 OPL33154.1 - 0.0081 16.2 0.2 0.97 9.5 0.0 3.0 3 0 0 3 3 3 1 C17orf99 Ig domain V-set_CD47 PF08204.11 OPL33154.1 - 1.4 8.9 7.1 0.99 9.4 1.3 2.7 2 2 1 3 3 3 0 CD47 immunoglobulin-like domain RCR PF12273.8 OPL33155.1 - 0.034 14.8 0.1 0.053 14.2 0.1 1.3 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Insulin_TMD PF17870.1 OPL33155.1 - 0.097 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment HEPN_DZIP3 PF18738.1 OPL33156.1 - 1.9e-11 43.9 0.1 2.7e-11 43.4 0.1 1.3 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN NAD_binding_1 PF00175.21 OPL33157.1 - 9.5e-18 64.8 0.1 1.5e-17 64.2 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PhoU PF01895.19 OPL33157.1 - 0.015 15.7 0.1 0.034 14.6 0.1 1.5 1 0 0 1 1 1 0 PhoU domain Atu4866 PF11512.8 OPL33157.1 - 0.055 13.9 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 Agrobacterium tumefaciens protein Atu4866 XPA_C PF05181.12 OPL33157.1 - 0.058 13.4 0.5 0.21 11.6 0.2 2.1 2 0 0 2 2 2 0 XPA protein C-terminus CARD PF00619.21 OPL33158.1 - 1.2e-05 25.2 0.0 2.3e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Caspase recruitment domain PA28_alpha PF02251.18 OPL33158.1 - 0.033 14.2 0.2 0.06 13.4 0.2 1.5 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit HCO3_cotransp PF00955.21 OPL33159.1 - 3.8e-61 207.5 3.7 4.2e-61 207.3 3.7 1.0 1 0 0 1 1 1 1 HCO3- transporter family HCO3_cotransp PF00955.21 OPL33160.1 - 7.9e-69 232.8 4.2 9.6e-62 209.4 0.3 2.2 1 1 1 2 2 2 2 HCO3- transporter family DUF5035 PF16438.5 OPL33161.1 - 0.013 15.4 4.6 0.013 15.4 4.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5035) TSC22 PF01166.18 OPL33161.1 - 1.6 9.1 15.4 0.46 10.8 1.9 4.5 4 0 0 4 4 4 0 TSC-22/dip/bun family NACHT PF05729.12 OPL33162.1 - 4.8e-06 26.6 0.6 1.1e-05 25.4 0.6 1.6 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 OPL33162.1 - 0.00012 22.5 4.0 0.00042 20.7 1.1 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 OPL33162.1 - 0.0078 16.6 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 OPL33162.1 - 2.7 8.0 7.3 20 5.2 2.6 3.0 2 1 1 3 3 3 0 AAA domain HeLo PF14479.6 OPL33163.1 - 0.031 14.1 1.6 0.054 13.3 1.6 1.4 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF4364 PF14277.6 OPL33163.1 - 0.052 13.3 1.0 0.11 12.3 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) CDC45 PF02724.14 OPL33163.1 - 1.2 7.4 10.2 1.3 7.3 10.2 1.2 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 OPL33163.1 - 3 7.1 9.0 5.1 6.4 9.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Rootletin PF15035.6 OPL33164.1 - 0.049 13.7 2.6 0.07 13.1 2.6 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion R3H-assoc PF13902.6 OPL33164.1 - 0.076 13.4 1.5 0.11 12.9 1.5 1.5 1 1 0 1 1 1 0 R3H-associated N-terminal domain C1q PF00386.21 OPL33165.1 - 8.6e-17 61.5 0.1 1.4e-16 60.9 0.1 1.3 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL33165.1 - 0.0023 17.9 1.4 0.0036 17.2 1.4 1.3 1 0 0 1 1 1 1 BclA C-terminal domain CHD5 PF04420.14 OPL33167.1 - 5e-21 75.2 0.7 6.6e-21 74.8 0.7 1.3 1 0 0 1 1 1 1 CHD5-like protein DUF2207 PF09972.9 OPL33167.1 - 0.12 11.1 1.0 0.36 9.5 0.0 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ctr PF04145.15 OPL33167.1 - 0.98 10.0 2.9 1.5 9.4 2.9 1.5 1 1 0 1 1 1 0 Ctr copper transporter family Ig_3 PF13927.6 OPL33168.1 - 5.2e-16 59.0 10.0 3e-07 30.9 0.5 3.9 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 OPL33168.1 - 6.8e-14 51.7 2.8 2.6e-06 27.4 0.0 4.1 3 1 1 4 4 4 3 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL33168.1 - 7.8e-11 42.2 9.5 1.1e-07 32.1 0.1 3.4 3 1 1 4 4 4 2 Immunoglobulin domain ig PF00047.25 OPL33168.1 - 2.8e-08 33.8 3.7 0.023 14.9 0.1 4.1 3 1 0 3 3 3 2 Immunoglobulin domain fn3 PF00041.21 OPL33168.1 - 1.2e-06 28.8 0.1 7.2e-06 26.3 0.1 2.2 2 0 0 2 2 2 1 Fibronectin type III domain V-set PF07686.17 OPL33168.1 - 0.00048 20.3 0.9 1.7 8.8 0.1 3.6 3 1 1 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.6 OPL33169.1 - 5.4e-23 81.4 14.0 5.8e-07 30.0 0.7 4.2 3 1 1 4 4 4 4 Immunoglobulin domain ig PF00047.25 OPL33169.1 - 7.2e-20 71.0 8.3 4.2e-05 23.6 0.6 4.3 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 OPL33169.1 - 8e-20 71.0 9.4 0.00058 20.2 0.3 4.1 3 1 1 4 4 4 4 Immunoglobulin domain C2-set_2 PF08205.12 OPL33169.1 - 2.9e-17 62.5 12.2 2.9e-05 24.0 0.3 4.7 3 2 1 4 4 4 4 CD80-like C2-set immunoglobulin domain I-set PF07679.16 OPL33169.1 - 2.1e-12 46.9 0.3 0.0098 15.9 0.0 4.2 3 1 1 4 4 4 3 Immunoglobulin I-set domain GFO_IDH_MocA_C PF02894.17 OPL33170.1 - 2.2e-07 30.9 0.0 6.8e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain Mak10 PF04112.13 OPL33170.1 - 0.067 12.7 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase EcoRI PF02963.16 OPL33170.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease EcoRI Ank_2 PF12796.7 OPL33171.1 - 1.5e-11 44.8 0.0 1.6e-05 25.4 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL33171.1 - 1.9e-10 41.1 2.1 6.6e-06 26.6 0.2 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL33171.1 - 4.9e-09 35.7 0.2 0.013 15.9 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 OPL33171.1 - 6.2e-08 32.8 0.0 0.0078 16.6 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 OPL33171.1 - 6e-05 23.3 1.2 0.11 12.9 0.2 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ig_3 PF13927.6 OPL33172.1 - 0.018 15.6 0.8 0.24 12.0 0.2 2.3 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 OPL33172.1 - 0.034 14.2 0.5 0.89 9.7 0.4 2.7 2 1 0 2 2 2 0 Immunoglobulin I-set domain LPMO_10 PF03067.15 OPL33173.1 - 8.8e-37 127.7 2.4 1.2e-36 127.3 2.4 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading MGC-24 PF05283.11 OPL33173.1 - 0.18 12.2 11.1 0.29 11.6 11.1 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin START PF01852.19 OPL33174.1 - 2.6e-11 43.3 0.0 3.5e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 START domain VWC PF00093.18 OPL33175.1 - 6.5e-09 36.0 33.2 0.0001 22.5 15.3 2.1 2 0 0 2 2 2 2 von Willebrand factor type C domain fn1 PF00039.18 OPL33175.1 - 0.032 14.4 7.3 0.032 14.4 7.3 3.1 2 1 0 2 2 2 0 Fibronectin type I domain PSI PF01437.25 OPL33176.1 - 0.009 16.5 16.1 0.021 15.4 16.1 1.6 1 0 0 1 1 1 1 Plexin repeat Tat PF00539.18 OPL33176.1 - 0.02 15.0 1.9 0.035 14.3 1.9 1.4 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) Tubulin_C PF03953.17 OPL33178.1 - 3.9e-21 75.5 0.2 7.2e-21 74.7 0.2 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain SEFIR PF08357.11 OPL33179.1 - 0.0098 16.2 0.1 0.034 14.4 0.1 1.9 1 1 0 1 1 1 1 SEFIR domain GPI2 PF06432.11 OPL33180.1 - 9.4e-27 94.2 2.2 1.1e-26 93.9 2.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase PaaX_C PF08223.11 OPL33180.1 - 0.081 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain HSP70 PF00012.20 OPL33181.1 - 1.3e-10 40.2 2.9 6.6e-10 37.8 0.4 2.5 2 1 0 2 2 2 2 Hsp70 protein DDR PF08841.10 OPL33181.1 - 0.074 12.0 0.8 0.21 10.5 0.8 1.8 1 1 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain C1q PF00386.21 OPL33182.1 - 3.2e-06 27.4 0.0 4.4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 C1q domain TNF PF00229.18 OPL33182.1 - 0.14 12.1 0.0 19 5.2 0.0 2.3 1 1 1 2 2 2 0 TNF(Tumour Necrosis Factor) family Fascin PF06268.13 OPL33183.1 - 2.6e-58 195.0 0.1 9.3e-20 70.9 0.0 4.4 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.12 OPL33183.1 - 1.2e-15 57.7 0.4 4.3e-05 23.3 0.0 4.1 2 1 2 4 4 4 4 FRG1-like domain DUF5060 PF16586.5 OPL33183.1 - 0.11 12.9 0.0 0.33 11.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5060) Flagellin_N PF00669.20 OPL33185.1 - 0.078 13.1 0.1 0.089 12.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region ZapD PF07072.11 OPL33185.1 - 0.12 12.1 1.0 0.14 11.9 1.0 1.0 1 0 0 1 1 1 0 Cell division protein Rho_GDI PF02115.17 OPL33186.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor Shisa PF13908.6 OPL33187.1 - 0.0013 19.0 7.3 0.25 11.6 0.9 2.5 1 1 1 2 2 2 2 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 OPL33187.1 - 0.021 15.7 0.0 11 7.0 0.0 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Death PF00531.22 OPL33188.1 - 4.1e-06 26.9 0.2 7.2e-06 26.1 0.2 1.4 1 0 0 1 1 1 1 Death domain B5 PF03484.15 OPL33188.1 - 0.15 12.4 0.0 1.1 9.6 0.0 2.2 2 1 0 2 2 2 0 tRNA synthetase B5 domain dCMP_cyt_deam_1 PF00383.23 OPL33189.1 - 1.3e-09 37.8 0.0 1.4e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Tet_JBP PF12851.7 OPL33190.1 - 4.5e-94 315.5 24.5 1.7e-92 310.4 24.5 2.3 1 1 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily Lectin_C PF00059.21 OPL33191.1 - 1.4e-15 58.0 5.4 1.4e-15 58.0 5.4 2.0 1 1 1 2 2 2 1 Lectin C-type domain Baculo_PEP_C PF04513.12 OPL33191.1 - 0.00047 20.2 0.1 0.00064 19.8 0.1 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1351 PF07083.11 OPL33191.1 - 0.053 13.3 0.0 0.075 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) DUF4618 PF15397.6 OPL33191.1 - 0.085 12.3 0.3 0.11 11.8 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) CdvA PF18822.1 OPL33191.1 - 0.13 12.1 0.2 0.19 11.6 0.2 1.3 1 0 0 1 1 1 0 CdvA-like coiled-coil domain HSP70 PF00012.20 OPL33192.1 - 5.1e-12 44.8 0.4 2.6e-11 42.4 0.1 2.1 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 OPL33192.1 - 0.00036 19.5 0.0 0.00084 18.2 0.0 1.6 1 0 0 1 1 1 1 MreB/Mbl protein Fibrinogen_C PF00147.18 OPL33193.1 - 7.5e-28 97.8 9.6 5.1e-21 75.5 3.4 3.5 2 2 0 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain EcoR124_C PF12008.8 OPL33193.1 - 0.0012 18.6 7.9 0.0019 17.9 7.9 1.2 1 0 0 1 1 1 1 Type I restriction and modification enzyme - subunit R C terminal Endonuc_Holl PF10107.9 OPL33193.1 - 0.002 18.0 2.1 0.0029 17.5 2.1 1.2 1 0 0 1 1 1 1 Endonuclease related to archaeal Holliday junction resolvase Phage_int_SAM_3 PF14659.6 OPL33193.1 - 0.0024 18.1 5.2 4.7 7.5 0.3 3.4 2 1 1 3 3 3 1 Phage integrase, N-terminal SAM-like domain DUF2207 PF09972.9 OPL33193.1 - 0.0029 16.4 0.9 0.0041 15.9 0.9 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) GlutR_dimer PF00745.20 OPL33193.1 - 0.026 15.0 0.7 0.041 14.3 0.7 1.4 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF2797 PF10977.8 OPL33193.1 - 0.028 14.3 1.3 0.043 13.7 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Mt_ATP-synt_B PF05405.14 OPL33193.1 - 0.036 13.7 4.8 0.052 13.2 4.8 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) NADH_dhqG_C PF09326.11 OPL33193.1 - 0.037 14.7 2.7 0.97 10.2 0.3 3.3 1 1 2 3 3 3 0 NADH-ubiquinone oxidoreductase subunit G, C-terminal ApoLp-III PF07464.11 OPL33193.1 - 0.038 14.1 6.9 0.067 13.3 6.9 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.7 OPL33193.1 - 0.051 14.1 10.1 9 6.9 10.1 2.4 1 1 0 1 1 1 0 YtxH-like protein Z1 PF10593.9 OPL33193.1 - 0.054 13.0 2.1 0.094 12.2 2.1 1.3 1 0 0 1 1 1 0 Z1 domain MHB PF16525.5 OPL33193.1 - 0.067 13.5 3.9 0.63 10.3 0.6 2.6 1 1 1 2 2 2 0 Haemophore, haem-binding Apolipoprotein PF01442.18 OPL33193.1 - 0.067 13.1 0.6 0.1 12.5 0.6 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain AAA_32 PF13654.6 OPL33193.1 - 0.073 11.8 3.5 0.11 11.3 3.5 1.1 1 0 0 1 1 1 0 AAA domain Pox_polyA_pol_N PF12630.7 OPL33193.1 - 0.096 13.1 6.5 11 6.5 1.7 3.1 1 1 2 3 3 3 0 Poxvirus poly(A) polymerase N-terminal domain Inositol_P PF00459.25 OPL33193.1 - 0.12 11.9 3.5 0.57 9.7 3.5 2.0 1 1 0 1 1 1 0 Inositol monophosphatase family QIL1 PF15884.5 OPL33193.1 - 0.14 12.7 0.8 1.2 9.8 0.3 2.4 1 1 1 2 2 2 0 MICOS complex subunit MIC13, QIL1 Carbpep_Y_N PF05388.11 OPL33193.1 - 0.16 12.5 3.5 3.3 8.3 0.3 2.1 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide Spore_GerAC PF05504.11 OPL33193.1 - 0.17 12.1 10.7 1 9.6 5.0 2.6 1 1 1 2 2 2 0 Spore germination B3/ GerAC like, C-terminal RapH_N PF18801.1 OPL33193.1 - 0.17 12.0 9.9 1.3 9.1 4.8 3.1 1 1 1 2 2 2 0 response regulator aspartate phosphatase H, N terminal DUF2120 PF09893.9 OPL33193.1 - 0.24 11.5 2.0 0.64 10.1 1.3 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Tox-HNH-HHH PF15637.6 OPL33193.1 - 0.28 11.4 3.4 25 5.1 0.1 3.1 1 1 2 3 3 3 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif SLS PF14611.6 OPL33193.1 - 0.3 10.9 4.5 2.7 7.8 4.5 2.1 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Spore_III_AB PF09548.10 OPL33193.1 - 0.49 10.5 3.2 3 7.9 2.5 2.3 2 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) DUF3848 PF12959.7 OPL33193.1 - 0.55 10.3 6.1 1.1 9.4 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3848) Ca_chan_IQ PF08763.11 OPL33193.1 - 0.56 10.4 3.3 12 6.2 0.5 3.1 1 1 2 3 3 3 0 Voltage gated calcium channel IQ domain DUF883 PF05957.13 OPL33193.1 - 0.73 10.5 1.9 2.1 9.0 1.9 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) RB_A PF01858.17 OPL33193.1 - 1.6 8.5 4.8 5.4 6.8 4.8 2.0 1 1 0 1 1 1 0 Retinoblastoma-associated protein A domain HU-CCDC81_bac_2 PF18175.1 OPL33193.1 - 1.8 8.5 4.4 46 4.0 0.1 3.3 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 DUF5442 PF17514.2 OPL33193.1 - 1.9 8.7 7.1 11 6.3 0.1 3.0 1 1 2 3 3 3 0 Family of unknown function (DUF5442) DUF1947 PF09183.10 OPL33193.1 - 2.1 8.7 9.2 32 4.9 0.4 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF1947) ATP-synt_B PF00430.18 OPL33193.1 - 6.6 6.8 7.3 2.2 8.4 0.8 1.8 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) THP2 PF09432.10 OPL33193.1 - 8.6 6.4 8.0 46 4.1 0.2 2.9 1 1 1 2 2 2 0 Tho complex subunit THP2 Dynein_light PF01221.18 OPL33193.1 - 9.9 6.6 7.4 14 6.0 1.3 2.6 1 1 1 2 2 2 0 Dynein light chain type 1 Peptidase_M14 PF00246.24 OPL33194.1 - 4.7e-45 154.6 0.0 5.2e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase Alpha_TIF PF02232.15 OPL33194.1 - 0.032 13.4 0.0 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 Alpha trans-inducing protein (Alpha-TIF) ApeC PF16977.5 OPL33195.1 - 3.3e-36 125.2 3.0 4.2e-35 121.6 3.0 1.9 1 1 0 1 1 1 1 C-terminal domain of apextrin TSC22 PF01166.18 OPL33196.1 - 1.7 9.0 21.4 1.1 9.6 6.1 4.6 3 2 1 4 4 4 0 TSC-22/dip/bun family Fcf1 PF04900.12 OPL33196.1 - 4.5 7.7 6.6 33 5.0 4.7 2.7 2 1 0 2 2 2 0 Fcf1 Ctr PF04145.15 OPL33197.1 - 0.0083 16.8 0.1 0.023 15.3 0.0 1.8 2 0 0 2 2 2 1 Ctr copper transporter family TNF PF00229.18 OPL33197.1 - 0.015 15.2 0.2 0.046 13.7 0.0 1.9 2 0 0 2 2 2 0 TNF(Tumour Necrosis Factor) family AP3B1_C PF14796.6 OPL33197.1 - 0.024 14.9 0.5 0.069 13.4 0.3 1.8 2 0 0 2 2 2 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal ABC_tran PF00005.27 OPL33198.1 - 2.1e-18 67.2 0.0 3.2e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 OPL33198.1 - 1.1e-05 25.0 0.0 1.2e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 OPL33198.1 - 0.024 14.9 0.3 0.22 11.8 0.3 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Caveolin PF01146.17 OPL33199.1 - 3.4e-30 104.7 0.3 6.7e-30 103.8 0.0 1.5 2 0 0 2 2 2 1 Caveolin Ank_4 PF13637.6 OPL33203.1 - 2.9e-07 30.9 0.0 5.6e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL33203.1 - 1.2e-05 25.8 0.0 1.9e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 OPL33203.1 - 2.3e-05 24.4 0.0 0.12 13.0 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 OPL33203.1 - 0.0013 19.0 0.1 0.0023 18.2 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Imm5 PF14423.6 OPL33203.1 - 0.024 14.9 0.0 0.031 14.5 0.0 1.2 1 0 0 1 1 1 0 Immunity protein Imm5 Lectin_legB PF00139.19 OPL33203.1 - 0.047 13.2 0.2 0.057 12.9 0.2 1.1 1 0 0 1 1 1 0 Legume lectin domain Ank PF00023.30 OPL33203.1 - 0.17 12.4 0.1 1.9 9.1 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat fn3 PF00041.21 OPL33204.1 - 5.9e-10 39.4 0.1 1.2e-09 38.4 0.1 1.5 1 1 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 OPL33204.1 - 0.1 13.2 0.1 0.29 11.7 0.1 1.8 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Ras PF00071.22 OPL33205.1 - 1.1e-22 80.3 0.2 1.3e-22 80.2 0.2 1.1 1 0 0 1 1 1 1 Ras family T2SSF PF00482.23 OPL33205.1 - 0.18 11.8 0.1 0.21 11.6 0.1 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Calpain_III PF01067.22 OPL33206.1 - 5.3e-27 94.8 0.0 5.7e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 Calpain large subunit, domain III Peptidase_C2 PF00648.21 OPL33207.1 - 3.7e-40 137.8 0.0 4.1e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C15 PF01470.17 OPL33208.1 - 1.6e-18 67.6 0.0 1.9e-18 67.4 0.0 1.0 1 0 0 1 1 1 1 Pyroglutamyl peptidase PgaPase_1 PF06162.12 OPL33208.1 - 4.7e-07 29.7 0.3 6.4e-07 29.3 0.3 1.1 1 0 0 1 1 1 1 Putative pyroglutamyl peptidase PgaPase_1 I-set PF07679.16 OPL33209.1 - 3.3e-10 39.9 0.0 8.9e-05 22.5 0.0 3.1 2 2 1 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33209.1 - 1.7e-09 38.1 0.0 0.0019 18.7 0.0 2.7 2 1 1 3 3 3 2 Immunoglobulin domain fn3 PF00041.21 OPL33209.1 - 2.6e-06 27.7 0.1 8.9e-06 26.0 0.0 1.9 2 0 0 2 2 2 1 Fibronectin type III domain Ig_2 PF13895.6 OPL33209.1 - 0.00085 19.6 1.3 0.13 12.6 0.0 2.7 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 OPL33209.1 - 0.036 14.2 0.1 0.39 10.9 0.0 2.4 3 0 0 3 3 3 0 Immunoglobulin domain Phage_tail_3 PF08813.11 OPL33209.1 - 0.1 12.2 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Phage tail tube protein, TTP Ig_3 PF13927.6 OPL33210.1 - 0.0015 19.1 1.4 0.0033 18.0 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain UPF0489 PF12640.7 OPL33212.1 - 1.2e-12 48.4 0.2 4.2e-12 46.7 0.2 1.9 1 1 0 1 1 1 1 UPF0489 domain MFS_1 PF07690.16 OPL33213.1 - 2e-34 119.1 11.1 1.4e-31 109.7 2.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 OPL33213.1 - 3.5e-09 36.1 12.9 2.7e-08 33.1 6.3 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 OPL33213.1 - 0.002 17.1 9.4 0.0067 15.3 3.9 3.2 1 1 0 2 2 2 1 MFS_1 like family OATP PF03137.20 OPL33213.1 - 0.0066 14.8 0.2 0.0066 14.8 0.2 2.4 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 OPL33213.1 - 0.014 14.7 6.4 0.025 13.9 6.4 1.4 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 OPL33213.1 - 2.1 6.6 9.5 1.7 6.9 1.0 2.9 1 1 2 3 3 3 0 Transmembrane secretion effector DUF2371 PF10177.9 OPL33213.1 - 2.5 8.3 4.0 1.1 9.4 0.1 2.3 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) EGF_2 PF07974.13 OPL33214.1 - 2e-05 24.9 9.0 8.8e-05 22.8 9.0 2.2 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 OPL33214.1 - 5.7 7.1 13.2 0.13 12.3 6.3 2.0 2 0 0 2 2 2 0 Tenascin EGF domain Ras PF00071.22 OPL33215.1 - 1.2e-51 174.6 0.0 1.3e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL33215.1 - 2e-20 73.2 0.0 2.8e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 OPL33215.1 - 5.9e-09 35.6 0.0 7e-09 35.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 OPL33215.1 - 0.00085 18.9 0.0 0.0023 17.5 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain DAP3 PF10236.9 OPL33215.1 - 0.0058 15.8 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 RsgA_GTPase PF03193.16 OPL33215.1 - 0.0075 16.2 0.1 0.49 10.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 OPL33215.1 - 0.023 14.2 0.1 0.056 13.0 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 OPL33215.1 - 0.056 13.8 0.0 0.091 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 OPL33215.1 - 0.085 12.6 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 OPL33215.1 - 0.1 12.3 0.1 0.78 9.4 0.2 2.0 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 OPL33215.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Y_phosphatase PF00102.27 OPL33216.1 - 2.2e-59 200.9 5.3 2.9e-30 105.6 2.2 2.2 1 1 1 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 OPL33216.1 - 2.3e-05 24.2 0.7 5.1e-05 23.1 0.6 1.9 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 OPL33216.1 - 0.00022 21.3 0.1 0.0019 18.2 0.0 2.1 1 1 1 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 OPL33216.1 - 0.0016 18.6 0.6 0.0039 17.3 0.1 1.9 1 1 1 2 2 2 1 Inositol hexakisphosphate Ribosomal_L18_c PF14204.6 OPL33216.1 - 0.12 13.3 2.4 0.3 12.0 0.8 2.4 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region Roc PF08477.13 OPL33217.1 - 9.5e-06 25.8 0.0 2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 OPL33217.1 - 0.00025 21.3 0.0 0.00035 20.8 0.0 1.3 1 1 0 1 1 1 1 AAA domain Ras PF00071.22 OPL33217.1 - 0.00034 20.2 0.1 0.00068 19.3 0.0 1.5 1 1 0 1 1 1 1 Ras family ABC_tran PF00005.27 OPL33217.1 - 0.0007 20.1 2.4 0.0011 19.5 2.4 1.3 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 OPL33217.1 - 0.0053 17.2 0.0 0.0071 16.8 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 OPL33217.1 - 0.0089 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DAP3 PF10236.9 OPL33217.1 - 0.009 15.2 0.0 0.019 14.1 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 MMR_HSR1 PF01926.23 OPL33217.1 - 0.01 15.9 0.1 0.016 15.3 0.1 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Arf PF00025.21 OPL33217.1 - 0.02 14.4 0.0 0.036 13.5 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_33 PF13671.6 OPL33217.1 - 0.031 14.4 0.2 0.047 13.9 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 OPL33217.1 - 0.037 14.5 4.7 0.056 13.9 4.5 1.4 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 OPL33217.1 - 0.039 14.0 0.5 0.48 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 OPL33217.1 - 0.04 13.9 0.5 0.1 12.6 0.5 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 OPL33217.1 - 0.041 13.6 0.0 0.092 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 OPL33217.1 - 0.042 13.7 1.1 0.35 10.6 0.0 2.0 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 OPL33217.1 - 0.058 12.9 0.3 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 OPL33217.1 - 0.06 12.5 0.3 0.11 11.7 0.3 1.5 1 1 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 OPL33217.1 - 0.063 13.2 0.1 0.12 12.3 0.0 1.5 2 0 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 OPL33217.1 - 0.066 13.6 0.1 0.16 12.4 0.1 1.9 1 1 0 1 1 1 0 RNA helicase AAA_15 PF13175.6 OPL33217.1 - 0.079 12.7 7.4 0.19 11.4 7.4 1.6 1 1 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 OPL33217.1 - 0.096 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 OPL33217.1 - 0.11 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 OPL33217.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 OPL33218.1 - 1.3e-08 35.0 0.1 5e-08 33.2 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL33218.1 - 0.0003 20.4 0.1 0.0006 19.4 0.1 1.7 1 1 0 1 1 1 1 Ras family Neur_chan_LBD PF02931.23 OPL33219.1 - 5.3e-49 166.6 2.6 6.7e-49 166.3 2.6 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain FRD2 PF03197.13 OPL33219.1 - 0.2 12.0 0.4 0.58 10.5 0.1 1.8 1 1 1 2 2 2 0 Bacteriophage FRD2 protein DUF4599 PF15371.6 OPL33220.1 - 0.034 14.7 2.2 0.051 14.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4599) Hairy_orange PF07527.13 OPL33221.1 - 3.3e-14 52.8 0.0 6.3e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.26 OPL33221.1 - 1.3e-13 50.7 4.2 2.4e-13 49.8 4.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Band_7 PF01145.25 OPL33222.1 - 1.2e-29 103.6 2.4 1.2e-29 103.6 2.4 2.0 2 1 1 3 3 3 1 SPFH domain / Band 7 family Band_7_C PF16200.5 OPL33222.1 - 4e-25 87.7 3.8 4e-25 87.7 3.8 2.2 2 0 0 2 2 2 1 C-terminal region of band_7 Band_7_1 PF13421.6 OPL33222.1 - 0.0062 16.3 0.2 0.025 14.3 0.1 2.1 2 0 0 2 2 2 1 SPFH domain-Band 7 family DUF4865 PF16157.5 OPL33222.1 - 2.2 8.2 4.9 0.78 9.7 0.3 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4865) PDZ PF00595.24 OPL33223.1 - 4.7e-12 46.1 0.5 1.2e-11 44.8 0.5 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 OPL33223.1 - 2.8e-05 24.3 0.9 0.009 16.3 0.1 2.8 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 OPL33223.1 - 5.6e-05 22.9 0.0 0.00041 20.1 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 OPL33224.1 - 2.9e-15 56.4 0.5 3.1e-06 27.4 0.1 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 OPL33224.1 - 1.9e-05 24.4 0.2 0.00059 19.6 0.1 2.3 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 OPL33224.1 - 0.00076 19.8 0.2 1.8 9.0 0.1 3.0 3 0 0 3 3 3 2 PDZ domain Ank_2 PF12796.7 OPL33225.1 - 5.3e-16 59.0 0.6 1.1e-07 32.4 0.2 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 OPL33225.1 - 2.4e-11 43.7 0.7 0.00032 20.9 0.3 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 OPL33225.1 - 8.9e-11 42.1 2.0 5.8e-05 23.6 0.2 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL33225.1 - 1e-10 40.8 3.3 0.0083 16.6 0.1 5.1 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 OPL33225.1 - 9.7e-09 35.3 0.8 0.019 15.4 0.1 4.9 4 0 0 4 4 4 2 Ankyrin repeat RNA_helicase PF00910.22 OPL33225.1 - 0.019 15.3 0.0 0.06 13.7 0.0 1.9 1 0 0 1 1 1 0 RNA helicase TPR_MLP1_2 PF07926.12 OPL33225.1 - 0.022 14.8 1.1 0.042 13.9 1.1 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein AAA PF00004.29 OPL33225.1 - 0.083 13.3 0.4 0.32 11.4 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 OPL33225.1 - 0.091 13.1 0.0 0.33 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 OPL33225.1 - 0.093 13.1 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain C1q PF00386.21 OPL33227.1 - 2.2e-10 40.8 0.1 3.9e-10 40.0 0.1 1.4 1 1 0 1 1 1 1 C1q domain BsuPI PF12690.7 OPL33227.1 - 0.019 15.0 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Intracellular proteinase inhibitor Spa1_C PF18218.1 OPL33228.1 - 0.17 12.3 1.9 14 6.2 0.4 2.9 2 1 1 3 3 3 0 Lantibiotic immunity protein Spa1 C-terminal domain Biopterin_H PF00351.21 OPL33229.1 - 1.2e-19 70.6 0.7 1.3e-19 70.4 0.1 1.4 2 0 0 2 2 2 1 Biopterin-dependent aromatic amino acid hydroxylase Ribosomal_L27A PF00828.19 OPL33230.1 - 1.1e-24 87.5 0.0 1.4e-24 87.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RTC4 PF14474.6 OPL33230.1 - 0.055 13.6 1.3 0.29 11.3 0.2 2.0 1 1 1 2 2 2 0 RTC4-like domain DDE_2 PF02914.15 OPL33230.1 - 0.062 13.0 0.0 0.083 12.6 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage Mu transposase fn3 PF00041.21 OPL33231.1 - 4e-15 55.9 0.1 1.1e-14 54.6 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain fn3_2 PF16893.5 OPL33231.1 - 0.011 15.8 0.0 0.034 14.3 0.0 1.8 1 0 0 1 1 1 0 Fibronectin type III domain RAM PF15320.6 OPL33231.1 - 3.3 8.4 10.5 3.9 8.2 9.0 1.9 1 1 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Acetyltransf_1 PF00583.25 OPL33232.1 - 3.7e-12 46.5 0.0 5.1e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 OPL33232.1 - 1.8e-08 34.3 0.0 2.5e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 OPL33232.1 - 3.1e-08 33.9 0.0 4.2e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 OPL33232.1 - 0.0018 18.3 0.1 0.0038 17.3 0.0 1.6 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 OPL33232.1 - 0.013 15.7 0.0 0.018 15.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1246 PF06849.12 OPL33232.1 - 0.2 11.7 0.0 0.96 9.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1246) Mito_fiss_reg PF05308.11 OPL33232.1 - 0.75 9.8 7.8 1.2 9.1 7.8 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Ribosomal_L50 PF10501.9 OPL33233.1 - 0.022 14.9 3.3 0.037 14.2 0.1 2.6 1 1 2 3 3 3 0 Ribosomal subunit 39S p450 PF00067.22 OPL33234.1 - 1.4e-15 57.0 2.9 1.7e-12 46.9 0.1 2.0 1 1 1 2 2 2 2 Cytochrome P450 OAS1_C PF10421.9 OPL33236.1 - 1.9e-13 50.3 4.3 9.6e-13 48.0 4.3 2.0 1 1 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus SMODS PF18144.1 OPL33236.1 - 0.0001 22.5 0.3 0.00024 21.3 0.1 1.6 2 0 0 2 2 2 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain NTP_transf_2 PF01909.23 OPL33236.1 - 0.0046 17.2 0.1 0.014 15.7 0.1 1.9 1 1 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D5 PF17406.2 OPL33236.1 - 0.028 14.2 0.1 0.053 13.3 0.1 1.4 1 0 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 TEX13 PF15186.6 OPL33236.1 - 0.15 11.7 0.5 0.35 10.5 0.5 1.6 1 1 0 1 1 1 0 Testis-expressed sequence 13 protein family HSCB_C PF07743.13 OPL33236.1 - 0.24 11.9 3.7 2.5 8.7 3.5 2.3 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain Spectrin PF00435.21 OPL33237.1 - 0.0042 17.5 0.6 0.0075 16.7 0.2 1.6 1 1 1 2 2 2 1 Spectrin repeat TACC_C PF05010.14 OPL33237.1 - 0.063 13.1 1.1 0.089 12.6 1.1 1.3 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Lipoprotein_6 PF01441.19 OPL33237.1 - 0.067 13.2 0.4 0.079 13.0 0.4 1.1 1 0 0 1 1 1 0 Lipoprotein WW PF00397.26 OPL33239.1 - 1.6e-09 37.7 15.1 4e-06 26.8 4.7 3.2 3 0 0 3 3 3 2 WW domain ORC6 PF05460.13 OPL33240.1 - 5.9e-06 25.8 0.2 0.0066 15.8 0.0 2.1 2 0 0 2 2 2 2 Origin recognition complex subunit 6 (ORC6) Carb_anhydrase PF00194.21 OPL33241.1 - 6.5e-80 268.3 0.1 7.4e-80 268.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase BIR PF00653.21 OPL33242.1 - 1.8e-27 95.8 10.7 2.1e-15 57.1 0.7 2.5 2 1 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 OPL33242.1 - 1.8e-05 24.8 2.5 0.0011 19.0 0.0 2.2 2 0 0 2 2 2 2 C3HC zinc finger-like SNF PF00209.18 OPL33244.1 - 7e-15 54.7 0.2 7.7e-15 54.6 0.2 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Met_gamma_lyase PF06838.11 OPL33246.1 - 0.14 10.7 0.0 0.16 10.4 0.0 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase Pkinase_Tyr PF07714.17 OPL33247.1 - 1.2e-13 50.9 0.0 2.1e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 OPL33247.1 - 5.8e-05 22.6 0.0 9.1e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF155 PF02582.14 OPL33248.1 - 1.3e-41 142.6 0.6 2.5e-41 141.7 0.6 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Cu2_monoox_C PF03712.15 OPL33249.1 - 7.8e-14 51.5 0.1 1.2e-13 50.9 0.1 1.3 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 OPL33249.1 - 3.1e-05 24.2 0.4 7.1e-05 23.1 0.4 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain DASH_Dad3 PF08656.10 OPL33250.1 - 0.0045 17.0 3.3 0.0066 16.5 2.4 1.8 2 0 0 2 2 2 1 DASH complex subunit Dad3 BCAS2 PF05700.11 OPL33250.1 - 0.0095 15.7 2.1 0.012 15.4 2.1 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) COG2 PF06148.11 OPL33250.1 - 0.016 15.3 1.6 0.021 14.9 1.6 1.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF5344 PF17279.2 OPL33250.1 - 0.056 14.0 1.7 1.3 9.7 0.1 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5344) FapA PF03961.13 OPL33250.1 - 0.18 10.3 3.0 0.19 10.3 3.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 OPL33250.1 - 0.25 11.8 3.3 1.9 8.9 0.5 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 OPL33250.1 - 0.42 10.8 4.4 0.54 10.4 1.0 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Mid2 PF04478.12 OPL33251.1 - 0.0077 16.1 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor ETRAMP PF09716.10 OPL33251.1 - 0.047 13.8 0.0 0.12 12.5 0.0 1.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) ThrE PF06738.12 OPL33251.1 - 0.055 12.8 0.5 0.098 12.0 0.0 1.7 2 1 0 2 2 2 0 Putative threonine/serine exporter Rax2 PF12768.7 OPL33251.1 - 0.084 12.3 0.0 0.17 11.3 0.0 1.5 2 0 0 2 2 2 0 Cortical protein marker for cell polarity tRNA_edit PF04073.15 OPL33251.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain DUF2273 PF10031.9 OPL33251.1 - 0.19 11.8 0.0 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 Small integral membrane protein (DUF2273) C1q PF00386.21 OPL33252.1 - 8e-18 64.9 0.1 1e-17 64.5 0.1 1.1 1 0 0 1 1 1 1 C1q domain C1q PF00386.21 OPL33253.1 - 1.9e-23 83.0 0.1 2.5e-23 82.6 0.1 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL33253.1 - 2.2e-05 24.4 0.6 3e-05 23.9 0.6 1.2 1 0 0 1 1 1 1 BclA C-terminal domain Aft1_HRA PF11786.8 OPL33253.1 - 0.097 13.0 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Aft1 HRA domain Phage_base_V PF04717.12 OPL33253.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Type VI secretion system, phage-baseplate injector CALCOCO1 PF07888.11 OPL33254.1 - 0.024 13.5 0.1 0.028 13.3 0.1 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like FH2 PF02181.23 OPL33255.1 - 1.1e-16 60.9 0.5 1.2e-16 60.8 0.5 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain FH2 PF02181.23 OPL33256.1 - 0.00024 20.4 5.3 0.00024 20.3 5.3 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain Gp-FAR-1 PF05823.12 OPL33256.1 - 0.01 16.2 1.7 0.012 16.0 1.1 1.4 1 1 0 1 1 1 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Mt_ATP-synt_D PF05873.12 OPL33256.1 - 0.016 15.0 3.2 0.024 14.5 3.2 1.4 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Apolipoprotein PF01442.18 OPL33256.1 - 0.02 14.8 0.1 0.023 14.6 0.1 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DHR10 PF18595.1 OPL33256.1 - 0.022 14.8 3.5 0.043 13.9 3.3 1.4 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain Lipoprotein_6 PF01441.19 OPL33256.1 - 0.03 14.3 3.8 0.035 14.1 3.8 1.0 1 0 0 1 1 1 0 Lipoprotein MtrG PF04210.13 OPL33256.1 - 0.034 14.0 2.9 0.13 12.1 0.6 2.1 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Jnk-SapK_ap_N PF09744.9 OPL33256.1 - 0.04 14.1 3.8 0.044 14.0 3.8 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TMPIT PF07851.13 OPL33256.1 - 0.048 12.9 2.4 0.048 12.9 2.4 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 OPL33256.1 - 0.064 13.3 0.9 0.078 13.0 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 OPL33256.1 - 0.1 12.8 1.3 0.29 11.4 1.3 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF2524 PF10732.9 OPL33256.1 - 0.12 12.6 1.3 5.7 7.3 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) YtxH PF12732.7 OPL33256.1 - 1.4 9.6 4.7 6.8 7.3 4.7 1.9 1 1 0 1 1 1 0 YtxH-like protein DUF3295 PF11702.8 OPL33258.1 - 0.28 10.5 0.0 0.4 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Roc PF08477.13 OPL33259.1 - 7.4e-05 22.9 0.1 0.00015 22.0 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 OPL33259.1 - 0.00051 19.5 0.0 0.0009 18.7 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family ABC_tran PF00005.27 OPL33259.1 - 0.0035 17.9 0.0 0.0055 17.2 0.0 1.3 1 1 0 1 1 1 1 ABC transporter G-alpha PF00503.20 OPL33259.1 - 0.0075 15.5 0.9 0.011 14.9 0.9 1.3 1 1 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 OPL33259.1 - 0.01 15.9 0.1 0.02 15.0 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 OPL33259.1 - 0.017 15.2 0.1 0.026 14.6 0.1 1.5 1 1 0 1 1 1 0 Dynamin family AAA_24 PF13479.6 OPL33259.1 - 0.021 14.6 0.1 0.026 14.2 0.1 1.3 1 1 0 1 1 1 0 AAA domain Ras PF00071.22 OPL33259.1 - 0.023 14.3 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Ras family SRPRB PF09439.10 OPL33259.1 - 0.023 14.1 0.0 0.045 13.2 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DAP3 PF10236.9 OPL33259.1 - 0.03 13.5 0.2 0.045 12.9 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 OPL33259.1 - 0.038 14.3 0.2 0.07 13.4 0.2 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 OPL33259.1 - 0.06 13.1 0.1 0.15 11.8 0.1 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 OPL33259.1 - 0.06 13.2 0.1 0.12 12.3 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase DUF4576 PF15144.6 OPL33259.1 - 0.082 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) AAA_14 PF13173.6 OPL33259.1 - 0.1 12.6 0.3 0.19 11.7 0.3 1.6 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 OPL33259.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 OPL33259.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Tmp39 PF10271.9 OPL33260.1 - 0.042 12.8 0.1 0.043 12.8 0.1 1.0 1 0 0 1 1 1 0 Putative transmembrane protein Acyl-CoA_dh_N PF02771.16 OPL33262.1 - 2.2e-27 96.0 0.0 3.9e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 OPL33262.1 - 2.4e-26 91.8 0.0 4.2e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 OPL33262.1 - 1.9e-22 80.1 0.2 3e-22 79.4 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 OPL33262.1 - 9.5e-11 42.1 0.2 1.5e-10 41.5 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 OPL33262.1 - 0.079 12.6 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Thioredoxin_8 PF13905.6 OPL33263.1 - 4.4e-31 107.1 0.0 5.9e-31 106.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 OPL33263.1 - 9.7e-10 38.9 0.0 1.3e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.20 OPL33263.1 - 1.2e-09 38.1 0.0 3.1e-06 27.1 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin AhpC-TSA PF00578.21 OPL33263.1 - 2.1e-07 30.9 0.0 2.9e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 OPL33263.1 - 0.00018 21.3 0.0 0.00023 20.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.6 OPL33263.1 - 0.018 14.8 0.0 0.94 9.3 0.0 2.1 1 1 0 1 1 1 0 Thioredoxin Methyltransf_7 PF03492.15 OPL33263.1 - 0.086 12.0 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase TraF PF13728.6 OPL33263.1 - 0.12 12.2 0.0 0.34 10.7 0.0 1.6 1 1 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 OPL33263.1 - 0.16 12.1 0.0 0.39 10.9 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like EB1 PF03271.17 OPL33264.1 - 4.9e-15 55.5 0.5 1.3e-14 54.2 0.5 1.7 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 OPL33264.1 - 4.8e-08 33.1 0.3 2.5e-07 30.8 0.0 2.1 2 1 1 3 3 3 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 OPL33264.1 - 0.0017 18.1 0.0 0.0048 16.7 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain Ank_2 PF12796.7 OPL33266.1 - 1.8e-47 159.9 2.4 1.9e-16 60.4 0.0 4.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL33266.1 - 3.4e-40 135.9 11.4 1e-07 32.3 0.1 6.8 3 1 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL33266.1 - 1.1e-35 117.6 2.6 2.4e-06 27.5 0.0 8.2 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 OPL33266.1 - 8.4e-34 115.2 1.9 3.4e-07 30.4 0.0 7.3 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 OPL33266.1 - 2.3e-30 103.7 5.2 6.7e-07 29.5 0.0 8.5 9 0 0 9 9 9 7 Ankyrin repeat C1q PF00386.21 OPL33267.1 - 1.2e-08 35.2 4.0 5e-07 30.0 4.0 2.1 1 1 0 1 1 1 1 C1q domain C1q PF00386.21 OPL33268.1 - 6.1e-17 62.0 0.2 7.8e-17 61.7 0.2 1.1 1 0 0 1 1 1 1 C1q domain FeoB_associated PF12669.7 OPL33268.1 - 0.064 13.7 6.2 0.12 12.8 6.2 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Pico_P1A PF02226.16 OPL33269.1 - 0.18 11.8 2.7 5.3 7.2 0.4 2.8 1 1 2 3 3 3 0 Picornavirus coat protein (VP4) Helicase_C PF00271.31 OPL33270.1 - 3.3e-14 53.2 0.0 1.3e-13 51.3 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RIG-I_C PF18119.1 OPL33270.1 - 1.6e-06 28.2 0.6 4e-06 26.9 0.6 1.8 1 0 0 1 1 1 1 RIG-I receptor C-terminal domain ResIII PF04851.15 OPL33270.1 - 7e-06 26.1 0.0 4.5e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 OPL33270.1 - 0.0007 19.4 0.0 0.0035 17.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Ribosomal_L24e PF01246.20 OPL33270.1 - 7.6 6.8 6.9 16 5.8 0.1 3.4 4 1 0 4 4 4 0 Ribosomal protein L24e I-set PF07679.16 OPL33271.1 - 1.1e-09 38.2 0.1 1.7e-09 37.6 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33271.1 - 6.2e-07 29.9 0.1 1e-06 29.2 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 OPL33271.1 - 3.8e-06 27.0 0.1 6.8e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL33271.1 - 0.0017 18.6 0.1 0.0029 17.9 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 OPL33271.1 - 0.002 18.3 0.8 0.013 15.6 0.8 2.0 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_5 PF16681.5 OPL33271.1 - 0.016 15.6 0.6 0.11 12.9 0.5 2.4 1 1 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF2118 PF09891.9 OPL33271.1 - 0.022 14.7 0.6 0.042 13.8 0.1 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) DUF727 PF05303.12 OPL33271.1 - 0.081 13.0 0.5 1.8 8.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF727) Invasin_D3 PF09134.10 OPL33271.1 - 0.098 13.0 0.2 0.36 11.2 0.1 1.8 2 0 0 2 2 2 0 Invasin, domain 3 Ig_3 PF13927.6 OPL33273.1 - 1.6e-18 67.0 2.8 3.6e-10 40.3 0.3 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL33273.1 - 3.3e-15 55.9 0.4 1.9e-08 34.2 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 OPL33273.1 - 8.4e-13 48.3 0.5 9.5e-08 32.1 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 OPL33273.1 - 4.7e-09 36.5 1.9 2.2e-06 27.9 0.3 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 OPL33273.1 - 2.7e-08 34.0 1.4 6.9e-05 23.0 0.5 2.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain Adeno_E3_CR1 PF02440.15 OPL33273.1 - 0.001 18.8 2.5 0.0013 18.4 0.4 2.0 2 1 0 2 2 2 1 Adenovirus E3 region protein CR1 C1-set PF07654.15 OPL33273.1 - 0.052 13.9 0.2 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Ig_6 PF18452.1 OPL33273.1 - 0.071 12.7 0.0 0.93 9.1 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain Ig_4 PF16680.5 OPL33273.1 - 3.3 8.0 4.9 22 5.4 1.3 2.9 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Y_Y_Y PF07495.13 OPL33274.1 - 5.8e-06 26.2 0.4 2.2e-05 24.3 0.4 2.0 1 0 0 1 1 1 1 Y_Y_Y domain Ank_5 PF13857.6 OPL33275.1 - 2.8e-13 49.8 0.0 2.6e-06 27.6 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 OPL33275.1 - 4.5e-13 49.4 0.0 1.2e-05 25.8 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL33275.1 - 2e-12 47.5 0.0 0.00015 22.2 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 OPL33275.1 - 1.8e-11 43.2 0.0 0.0016 18.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 OPL33275.1 - 3.3e-07 30.5 0.0 0.02 15.3 0.0 3.3 4 0 0 4 4 4 2 Ankyrin repeat AAA_assoc_2 PF16193.5 OPL33275.1 - 0.041 14.2 0.3 0.083 13.2 0.3 1.4 1 0 0 1 1 1 0 AAA C-terminal domain LepB_N PF18640.1 OPL33275.1 - 0.089 12.4 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 LepB N-terminal domain Neur_chan_memb PF02932.16 OPL33277.1 - 6.5e-23 82.0 0.1 8e-23 81.7 0.1 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2207 PF09972.9 OPL33277.1 - 0.043 12.6 0.8 0.56 8.9 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF2304 PF10066.9 OPL33277.1 - 1.2 9.3 9.2 0.07 13.4 1.9 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) WBP-1 PF11669.8 OPL33279.1 - 0.00033 21.3 1.0 0.00033 21.3 1.0 3.2 3 1 1 4 4 4 1 WW domain-binding protein 1 EphA2_TM PF14575.6 OPL33279.1 - 0.00039 21.3 0.0 0.0018 19.1 0.0 2.2 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain LapA_dom PF06305.11 OPL33279.1 - 0.032 14.1 0.1 0.075 12.9 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PhoR PF11808.8 OPL33279.1 - 0.033 14.6 0.0 0.059 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR Vpu PF00558.19 OPL33279.1 - 0.12 12.1 2.2 0.27 11.0 2.2 1.5 1 0 0 1 1 1 0 Vpu protein Syndecan PF01034.20 OPL33279.1 - 0.27 11.2 1.1 0.54 10.2 1.1 1.4 1 0 0 1 1 1 0 Syndecan domain TMIE PF16038.5 OPL33279.1 - 0.46 10.4 5.1 1.2 9.0 5.1 1.7 1 0 0 1 1 1 0 TMIE protein FAM163 PF15069.6 OPL33279.1 - 2.4 8.6 6.3 0.35 11.3 0.2 2.4 2 2 0 2 2 2 0 FAM163 family RIFIN PF02009.16 OPL33279.1 - 6.3 6.6 8.0 0.52 10.1 1.6 2.0 2 0 0 2 2 2 0 Rifin HEPN_DZIP3 PF18738.1 OPL33281.1 - 3.1e-26 91.8 0.0 9e-26 90.3 0.0 1.7 2 0 0 2 2 2 1 DZIP3/ hRUL138-like HEPN Zeta_toxin PF06414.12 OPL33281.1 - 0.0035 16.7 0.0 0.0085 15.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 OPL33281.1 - 0.0057 16.9 0.0 0.015 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 OPL33281.1 - 0.0071 15.4 0.5 0.013 14.6 0.5 1.4 1 1 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 OPL33281.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 OPL33281.1 - 0.029 14.1 0.1 0.065 12.9 0.0 1.5 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 OPL33281.1 - 0.039 13.5 3.2 0.37 10.3 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 OPL33281.1 - 0.044 13.3 0.3 0.1 12.1 0.1 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region DEAD PF00270.29 OPL33281.1 - 0.052 13.3 0.2 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF853 PF05872.12 OPL33281.1 - 0.054 12.1 0.0 0.078 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) AAA_11 PF13086.6 OPL33281.1 - 0.066 13.0 0.6 11 5.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 OPL33281.1 - 0.092 13.1 0.0 0.26 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF3450 PF11932.8 OPL33281.1 - 0.14 11.5 3.0 0.21 10.8 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) mCpol PF18182.1 OPL33281.1 - 0.18 12.2 1.1 0.28 11.5 0.1 1.8 2 0 0 2 2 2 0 minimal CRISPR polymerase domain PI_PP_I PF18363.1 OPL33281.1 - 0.57 10.4 4.4 4.1 7.6 0.9 2.7 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain Death PF00531.22 OPL33282.1 - 1.1e-08 35.2 3.0 6.1e-06 26.3 0.0 3.1 3 0 0 3 3 3 2 Death domain Big_3_3 PF13750.6 OPL33283.1 - 0.031 13.9 0.2 1.8 8.2 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) MIEAP PF16026.5 OPL33284.1 - 9.4e-14 52.1 0.0 1.5e-13 51.4 0.0 1.4 1 1 0 1 1 1 1 Mitochondria-eating protein DUF2205 PF10224.9 OPL33285.1 - 1.2e-25 89.3 2.1 1.8e-25 88.7 2.1 1.2 1 0 0 1 1 1 1 Short coiled-coil protein HALZ PF02183.18 OPL33285.1 - 0.00053 20.2 7.6 0.029 14.6 2.6 2.3 1 1 1 2 2 2 2 Homeobox associated leucine zipper KASH_CCD PF14662.6 OPL33285.1 - 0.00063 19.6 1.7 0.00077 19.3 1.7 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Myosin_tail_1 PF01576.19 OPL33285.1 - 0.0017 16.3 0.9 0.0019 16.1 0.9 1.0 1 0 0 1 1 1 1 Myosin tail CENP-H PF05837.12 OPL33285.1 - 0.0021 18.5 1.5 0.0029 18.0 1.5 1.2 1 0 0 1 1 1 1 Centromere protein H (CENP-H) DUF812 PF05667.11 OPL33285.1 - 0.0022 17.0 0.5 0.0024 16.9 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) YabA PF06156.13 OPL33285.1 - 0.0035 18.0 1.2 0.005 17.4 1.2 1.2 1 0 0 1 1 1 1 Initiation control protein YabA FlaC_arch PF05377.11 OPL33285.1 - 0.0035 17.7 1.7 0.006 16.9 1.7 1.4 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) Taxilin PF09728.9 OPL33285.1 - 0.0061 15.8 1.4 0.0078 15.4 1.4 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein FliT PF05400.13 OPL33285.1 - 0.02 15.7 0.1 0.03 15.1 0.1 1.3 1 0 0 1 1 1 0 Flagellar protein FliT RasGAP_C PF03836.15 OPL33285.1 - 0.031 14.4 0.7 0.046 13.9 0.7 1.3 1 0 0 1 1 1 0 RasGAP C-terminus DASH_Dad4 PF08650.10 OPL33285.1 - 0.034 14.1 0.5 0.061 13.3 0.5 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad4 bZIP_1 PF00170.21 OPL33285.1 - 0.053 13.6 2.2 0.096 12.8 2.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor ZapB PF06005.12 OPL33285.1 - 0.058 13.8 4.1 0.087 13.3 4.1 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Sas10_Utp3 PF04000.15 OPL33285.1 - 0.097 13.3 1.3 0.16 12.6 1.3 1.4 1 0 0 1 1 1 0 Sas10/Utp3/C1D family Cep57_CLD_2 PF14197.6 OPL33285.1 - 0.098 12.8 3.5 0.18 11.9 3.5 1.5 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 Roc PF08477.13 OPL33286.1 - 3.5e-15 56.3 2.1 2.8e-08 34.0 0.6 2.8 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL33286.1 - 6.6e-07 29.1 0.2 0.041 13.5 0.0 2.5 2 0 0 2 2 2 2 Ras family AAA_18 PF13238.6 OPL33286.1 - 0.0011 19.5 0.2 0.005 17.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 OPL33286.1 - 0.003 18.1 1.9 0.003 18.1 1.9 2.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 OPL33286.1 - 0.007 16.1 0.1 0.35 10.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 OPL33286.1 - 0.0092 15.9 0.2 0.028 14.3 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 OPL33286.1 - 0.012 15.7 0.1 0.078 13.1 0.0 2.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase Arf PF00025.21 OPL33286.1 - 0.027 13.9 1.3 0.54 9.7 0.0 3.2 3 1 1 4 4 4 0 ADP-ribosylation factor family Inhibitor_I29 PF08246.12 OPL33286.1 - 0.029 14.8 1.2 0.1 13.0 1.2 1.9 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) AAA PF00004.29 OPL33286.1 - 0.035 14.5 0.0 0.31 11.5 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 OPL33286.1 - 0.04 13.7 0.0 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 OPL33286.1 - 0.065 13.6 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 OPL33286.1 - 0.078 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 OPL33286.1 - 0.089 13.1 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain TMEM154 PF15102.6 OPL33287.1 - 5.1e-05 23.2 0.4 9e-05 22.4 0.4 1.3 1 0 0 1 1 1 1 TMEM154 protein family Rax2 PF12768.7 OPL33287.1 - 0.00079 18.9 0.1 0.001 18.6 0.1 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Podoplanin PF05808.11 OPL33287.1 - 0.0023 18.1 2.1 0.0035 17.5 2.1 1.4 1 0 0 1 1 1 1 Podoplanin DAG1 PF05454.11 OPL33287.1 - 0.0026 17.2 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF2207 PF09972.9 OPL33287.1 - 0.0037 16.1 0.1 0.0044 15.8 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Amnionless PF14828.6 OPL33287.1 - 0.011 14.5 0.0 0.018 13.9 0.0 1.3 1 1 0 1 1 1 0 Amnionless Stevor PF17410.2 OPL33287.1 - 0.032 13.8 0.4 0.043 13.4 0.4 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Syndecan PF01034.20 OPL33287.1 - 0.032 14.2 0.5 0.062 13.2 0.5 1.4 1 0 0 1 1 1 0 Syndecan domain Mid2 PF04478.12 OPL33287.1 - 0.039 13.8 1.4 0.076 12.8 1.4 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF5305 PF17231.2 OPL33287.1 - 0.062 12.7 0.8 0.092 12.1 0.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Peptidase_M56 PF05569.11 OPL33287.1 - 0.062 12.5 0.1 0.086 12.0 0.1 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 EphA2_TM PF14575.6 OPL33287.1 - 0.085 13.7 0.0 0.16 12.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3377 PF11857.8 OPL33287.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) S1FA PF04689.13 OPL33287.1 - 0.13 12.4 2.7 0.14 12.3 0.2 2.1 2 0 0 2 2 2 0 DNA binding protein S1FA Insulin_TMD PF17870.1 OPL33287.1 - 0.13 12.4 0.2 0.13 12.4 0.2 1.6 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Chordopox_A13L PF05961.11 OPL33287.1 - 0.15 12.4 0.1 0.15 12.4 0.1 2.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein MGC-24 PF05283.11 OPL33287.1 - 0.23 11.9 5.2 0.5 10.8 5.2 1.6 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF3439 PF11921.8 OPL33287.1 - 1.1 9.3 11.6 1.9 8.5 11.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) C1q PF00386.21 OPL33288.1 - 5e-11 42.9 0.2 1.7e-10 41.2 0.2 1.9 1 0 0 1 1 1 1 C1q domain Macoilin PF09726.9 OPL33288.1 - 1.7 7.1 28.9 2.4 6.6 28.9 1.1 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 OPL33288.1 - 5.3 5.2 17.5 7.6 4.7 17.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Fibrinogen_C PF00147.18 OPL33289.1 - 2.6e-36 125.5 8.4 3.2e-36 125.2 8.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Peptidase_C48 PF02902.19 OPL33290.1 - 3.4e-11 43.4 0.6 3.4e-11 43.4 0.6 3.2 3 1 1 4 4 4 2 Ulp1 protease family, C-terminal catalytic domain VPS11_C PF12451.8 OPL33290.1 - 1.4 9.2 5.8 3.6 7.9 0.2 2.4 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal zf-CpG_bind_C PF12269.8 OPL33291.1 - 0.022 14.6 4.6 0.025 14.3 4.6 1.1 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Fmp27_WPPW PF10359.9 OPL33291.1 - 0.18 10.6 10.4 0.23 10.3 10.4 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Conotoxin PF02950.17 OPL33291.1 - 0.9 10.6 5.4 1.4 9.9 0.3 2.1 2 0 0 2 2 2 0 Conotoxin ALMT PF11744.8 OPL33291.1 - 1.7 7.4 8.0 1.6 7.5 8.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 OPL33291.1 - 9.1 4.9 8.9 10 4.8 8.9 1.0 1 0 0 1 1 1 0 Presenilin MOSC_N PF03476.16 OPL33292.1 - 4.4e-23 81.4 0.0 2e-22 79.3 0.0 1.9 2 0 0 2 2 2 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 OPL33292.1 - 1.2e-18 67.4 0.0 5.2e-16 58.9 0.0 2.4 1 1 0 1 1 1 1 MOSC domain MTD PF01993.18 OPL33292.1 - 0.12 11.6 0.0 0.29 10.4 0.0 1.5 2 0 0 2 2 2 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase COR PF16095.5 OPL33293.1 - 1.1e-08 35.2 0.0 3.5e-08 33.5 0.0 1.8 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Death PF00531.22 OPL33293.1 - 0.078 13.1 0.0 0.35 11.1 0.0 2.0 2 0 0 2 2 2 0 Death domain DUF3155 PF11352.8 OPL33293.1 - 0.093 13.2 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3155) CBM_14 PF01607.24 OPL33293.1 - 0.44 10.8 2.5 0.9 9.8 2.5 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Death PF00531.22 OPL33294.1 - 0.0049 17.0 0.0 0.0075 16.4 0.0 1.4 1 0 0 1 1 1 1 Death domain Transglut_core PF01841.19 OPL33295.1 - 0.031 14.7 1.1 1 9.8 0.0 2.5 1 1 1 2 2 2 0 Transglutaminase-like superfamily PPC PF04151.15 OPL33295.1 - 0.055 14.6 0.0 0.11 13.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain Kringle PF00051.18 OPL33298.1 - 3.4e-59 197.1 44.1 1.2e-21 76.7 9.8 4.8 3 0 0 3 3 3 3 Kringle domain Claudin_3 PF06653.11 OPL33299.1 - 6.3e-05 23.0 8.0 0.0012 18.8 8.0 2.3 1 1 0 1 1 1 1 Tight junction protein, Claudin-like Claudin_2 PF13903.6 OPL33299.1 - 0.00023 21.0 5.6 0.039 13.7 1.6 2.4 2 1 0 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction DUF308 PF03729.13 OPL33299.1 - 0.00059 20.1 5.5 0.75 10.2 0.0 3.2 3 1 0 3 3 3 2 Short repeat of unknown function (DUF308) Ldl_recept_b PF00058.17 OPL33300.1 - 7.3e-21 74.4 9.8 4.6e-09 36.6 0.0 5.2 5 1 1 6 6 6 4 Low-density lipoprotein receptor repeat class B SGL PF08450.12 OPL33300.1 - 1.4e-05 24.8 0.8 0.0032 17.1 0.7 3.7 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region FXa_inhibition PF14670.6 OPL33300.1 - 0.00065 19.9 0.8 0.0012 19.1 0.8 1.5 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Glu_cyclase_2 PF05096.12 OPL33300.1 - 0.14 11.6 0.3 2.4 7.5 0.0 2.1 2 0 0 2 2 2 0 Glutamine cyclotransferase LSDAT_euk PF18139.1 OPL33301.1 - 3.4e-13 49.6 0.0 6e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM Mem_trans PF03547.18 OPL33301.1 - 0.014 13.8 0.0 0.014 13.8 0.0 1.1 1 0 0 1 1 1 0 Membrane transport protein HCO3_cotransp PF00955.21 OPL33302.1 - 4.9e-08 32.2 1.2 7e-08 31.7 1.2 1.2 1 0 0 1 1 1 1 HCO3- transporter family MFS_3 PF05977.13 OPL33302.1 - 0.22 9.9 0.0 0.23 9.8 0.0 1.2 1 0 0 1 1 1 0 Transmembrane secretion effector fn3 PF00041.21 OPL33303.1 - 0.0037 17.6 0.6 1.2 9.5 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain DUF642 PF04862.12 OPL33305.1 - 0.0041 16.9 0.0 0.0086 15.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF642) DUF5605 PF18310.1 OPL33305.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) C2-set_2 PF08205.12 OPL33306.1 - 0.0012 18.8 0.0 0.82 9.8 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain CBM_14 PF01607.24 OPL33306.1 - 0.0022 18.1 2.5 0.0054 16.9 2.5 1.7 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain TLD PF07534.16 OPL33307.1 - 1.5e-15 57.6 1.8 2.1e-15 57.1 1.3 1.5 2 0 0 2 2 2 1 TLD Coprogen_oxidas PF01218.18 OPL33307.1 - 0.06 12.1 0.0 0.084 11.6 0.0 1.2 1 0 0 1 1 1 0 Coproporphyrinogen III oxidase APG6_N PF17675.1 OPL33308.1 - 0.00039 21.0 30.3 0.0069 16.9 26.2 2.3 1 1 1 2 2 2 1 Apg6 coiled-coil region ATG16 PF08614.11 OPL33308.1 - 0.017 15.4 16.4 0.017 15.4 16.4 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DNA_methylase PF00145.17 OPL33308.1 - 0.071 12.4 9.6 0.1 11.9 9.6 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Tropomyosin_1 PF12718.7 OPL33308.1 - 0.085 13.0 34.3 0.12 12.6 22.5 3.3 1 1 1 3 3 3 0 Tropomyosin like GAS PF13851.6 OPL33308.1 - 0.087 12.2 31.1 0.26 10.6 2.9 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 OPL33308.1 - 0.53 9.5 22.9 2.2 7.5 9.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TolA_bind_tri PF16331.5 OPL33308.1 - 2.2 8.4 20.1 0.11 12.6 4.7 3.4 2 1 2 4 4 4 0 TolA binding protein trimerisation PRKG1_interact PF15898.5 OPL33308.1 - 4 8.4 31.6 8.8 7.3 16.6 3.5 1 1 3 4 4 4 0 cGMP-dependent protein kinase interacting domain V_ATPase_I PF01496.19 OPL33308.1 - 5 4.9 21.3 0.25 9.2 9.1 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF724 PF05266.14 OPL33308.1 - 9.3 6.0 22.8 36 4.1 12.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HCO3_cotransp PF00955.21 OPL33309.1 - 6.8e-85 285.8 14.2 7.6e-50 170.2 3.9 2.0 1 1 1 2 2 2 2 HCO3- transporter family T4_Rnl2_C PF18043.1 OPL33309.1 - 0.018 15.2 0.9 0.81 9.9 0.1 2.9 2 1 1 3 3 3 0 T4 RNA ligase 2 C-terminal Sulfate_transp PF00916.20 OPL33309.1 - 0.037 12.8 0.1 0.037 12.8 0.1 2.4 3 0 0 3 3 3 0 Sulfate permease family Na_Ca_ex PF01699.24 OPL33309.1 - 3.5 7.6 14.1 0.042 13.8 4.6 2.3 2 1 0 2 2 2 0 Sodium/calcium exchanger protein Pkinase_Tyr PF07714.17 OPL33310.1 - 7.2e-27 94.3 0.0 1.1e-26 93.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 OPL33310.1 - 2e-26 92.9 0.1 4e-26 92.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF1444 PF07285.11 OPL33310.1 - 0.0092 15.6 3.0 0.0092 15.6 3.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1444) DUF2371 PF10177.9 OPL33310.1 - 0.021 15.0 0.3 0.088 13.0 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) UPF0147 PF03685.13 OPL33310.1 - 0.08 13.0 2.1 34 4.6 0.7 3.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0147) RGS PF00615.19 OPL33310.1 - 0.29 11.4 2.0 1.6 9.0 0.1 2.7 2 0 0 2 2 2 0 Regulator of G protein signaling domain DUF4436 PF14494.6 OPL33311.1 - 0.0016 17.8 0.1 0.0022 17.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4436) Ras PF00071.22 OPL33312.1 - 1.3e-34 119.1 0.0 1.5e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL33312.1 - 2.5e-27 95.5 0.0 3.2e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 OPL33312.1 - 2.6e-07 30.2 0.0 3.3e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 OPL33312.1 - 0.0035 17.3 0.1 0.27 11.1 0.0 2.7 1 1 1 3 3 3 1 RsgA GTPase PduV-EutP PF10662.9 OPL33312.1 - 0.007 16.1 0.0 0.029 14.1 0.0 1.9 1 1 1 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 OPL33312.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 OPL33312.1 - 0.03 14.0 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 OPL33312.1 - 0.047 13.8 0.0 0.091 12.8 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 OPL33312.1 - 0.068 12.7 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 OPL33312.1 - 0.073 12.5 0.0 0.097 12.1 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit UPF0262 PF06793.12 OPL33312.1 - 0.093 12.8 0.0 0.72 9.9 0.0 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0262) AAA_22 PF13401.6 OPL33312.1 - 0.13 12.6 0.0 0.25 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 OPL33312.1 - 0.13 12.6 0.0 0.16 12.4 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain MFS_1 PF07690.16 OPL33313.1 - 4.5e-05 22.5 0.1 4.5e-05 22.5 0.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Osw5 PF17062.5 OPL33313.1 - 0.054 13.6 0.1 0.086 12.9 0.1 1.3 1 0 0 1 1 1 0 Outer spore wall 5 PUCC PF03209.15 OPL33313.1 - 0.062 12.3 0.8 0.077 12.0 0.8 1.1 1 0 0 1 1 1 0 PUCC protein DUF5631 PF18645.1 OPL33313.1 - 0.09 13.2 0.0 0.12 12.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5631) BTB PF00651.31 OPL33316.1 - 6.9e-10 39.1 0.0 1.1e-07 32.1 0.0 2.5 1 1 0 1 1 1 1 BTB/POZ domain PAN_1 PF00024.26 OPL33316.1 - 0.0009 19.2 0.2 0.0018 18.2 0.2 1.4 1 0 0 1 1 1 1 PAN domain Methyltransf_FA PF12248.8 OPL33316.1 - 0.031 14.6 0.0 0.49 10.8 0.0 2.4 2 0 0 2 2 2 0 Farnesoic acid 0-methyl transferase Reeler PF02014.16 OPL33317.1 - 6.8e-32 110.9 0.9 1.1e-31 110.3 0.9 1.3 1 0 0 1 1 1 1 Reeler domain PCNA_N PF00705.18 OPL33317.1 - 0.085 12.6 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain DUF3683 PF12447.8 OPL33318.1 - 0.029 14.5 1.3 0.029 14.5 1.3 2.6 2 2 1 3 3 3 0 Protein of unknown function (DUF3683) Rx_N PF18052.1 OPL33318.1 - 1.1 9.5 10.1 0.13 12.5 4.1 2.2 2 0 0 2 2 2 0 Rx N-terminal domain RGS PF00615.19 OPL33319.1 - 4.1e-19 69.0 1.2 4.1e-19 69.0 1.2 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain PX PF00787.24 OPL33319.1 - 0.023 14.7 0.0 0.069 13.1 0.0 1.8 1 0 0 1 1 1 0 PX domain Eco57I PF07669.11 OPL33319.1 - 0.028 14.9 0.5 0.11 13.0 0.2 2.1 1 1 0 1 1 1 0 Eco57I restriction-modification methylase TMEM95 PF15203.6 OPL33319.1 - 1.4 8.5 4.8 3.1 7.4 0.8 2.7 2 1 1 3 3 3 0 TMEM95 family Noelin-1 PF12308.8 OPL33319.1 - 7.4 6.6 7.0 2.9 8.0 2.2 2.4 2 0 0 2 2 2 0 Neurogenesis glycoprotein Y_phosphatase PF00102.27 OPL33321.1 - 2.1e-111 371.1 11.6 1.3e-72 244.2 6.3 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 OPL33321.1 - 6.4e-08 32.5 0.3 0.0062 16.4 0.0 2.9 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 OPL33321.1 - 7.4e-07 29.4 0.1 0.00015 21.9 0.0 3.1 2 1 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 OPL33321.1 - 6.1e-05 23.1 0.5 0.04 13.9 0.0 3.1 3 0 0 3 3 3 2 Tyrosine phosphatase family Integrin_beta PF00362.18 OPL33321.1 - 0.00056 19.6 1.8 0.39 10.3 0.0 2.4 2 0 0 2 2 2 2 Integrin beta chain VWA domain HEPN_DZIP3 PF18738.1 OPL33322.1 - 4.7e-31 107.5 0.0 1.5e-30 105.8 0.0 1.8 1 1 0 1 1 1 1 DZIP3/ hRUL138-like HEPN CARD PF00619.21 OPL33322.1 - 1.6e-07 31.3 0.9 5e-07 29.7 0.9 1.9 1 0 0 1 1 1 1 Caspase recruitment domain Spc7 PF08317.11 OPL33322.1 - 0.013 14.4 4.7 0.019 13.9 4.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1043 PF06295.12 OPL33322.1 - 0.063 13.3 2.8 0.13 12.3 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) MRP-S26 PF14943.6 OPL33322.1 - 0.12 12.2 8.3 6.8 6.6 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 DUF724 PF05266.14 OPL33322.1 - 0.54 10.1 4.0 1.2 9.0 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Shisa PF13908.6 OPL33323.1 - 0.0012 19.1 1.9 0.0014 18.9 1.9 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator CYYR1 PF10873.8 OPL33323.1 - 0.0039 17.6 9.5 0.0052 17.3 9.5 1.2 1 0 0 1 1 1 1 Cysteine and tyrosine-rich protein 1 SARAF PF06682.12 OPL33323.1 - 0.42 10.2 2.4 0.68 9.5 2.4 1.4 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Mito_fiss_reg PF05308.11 OPL33323.1 - 0.44 10.6 7.4 0.52 10.4 7.4 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 OPL33323.1 - 0.88 9.0 9.8 1.1 8.7 9.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TMEM174 PF15029.6 OPL33323.1 - 2.5 7.7 6.6 3.6 7.2 6.6 1.3 1 1 0 1 1 1 0 Transmembrane protein 174 FYVE PF01363.21 OPL33325.1 - 1.9e-17 63.2 15.8 3.8e-17 62.2 15.8 1.5 1 0 0 1 1 1 1 FYVE zinc finger Arm PF00514.23 OPL33325.1 - 0.00047 20.1 11.1 2.1 8.5 0.1 5.5 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat Sec7_N PF12783.7 OPL33325.1 - 0.11 12.4 1.2 0.22 11.4 0.2 2.0 2 0 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Methyltransf_25 PF13649.6 OPL33327.1 - 2.8e-06 27.9 0.0 3.4e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 OPL33327.1 - 0.00015 21.6 0.0 0.00016 21.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 OPL33327.1 - 0.00055 20.5 0.0 0.00064 20.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 OPL33327.1 - 0.0013 18.3 0.0 0.0014 18.2 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 OPL33327.1 - 0.0056 15.8 0.0 0.006 15.7 0.0 1.1 1 0 0 1 1 1 1 DREV methyltransferase RrnaAD PF00398.20 OPL33327.1 - 0.0062 15.6 0.0 0.0065 15.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_PK PF05891.12 OPL33327.1 - 0.0093 15.5 0.0 0.0093 15.5 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_12 PF08242.12 OPL33327.1 - 0.012 16.4 0.0 0.014 16.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 OPL33327.1 - 0.091 12.6 0.0 0.099 12.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain MgsA_C PF12002.8 OPL33328.1 - 0.13 12.2 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal HEPN_DZIP3 PF18738.1 OPL33329.1 - 7.8e-07 28.9 0.2 1.3e-06 28.2 0.2 1.5 1 1 0 1 1 1 1 DZIP3/ hRUL138-like HEPN Nudix_N PF12535.8 OPL33329.1 - 0.054 13.1 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal EGF_2 PF07974.13 OPL33331.1 - 6.6e-12 45.6 67.5 0.00015 22.0 8.4 4.1 4 0 0 4 4 4 4 EGF-like domain EGF PF00008.27 OPL33331.1 - 2.6e-08 34.0 58.1 0.00051 20.3 9.7 4.9 4 1 0 4 4 4 4 EGF-like domain hEGF PF12661.7 OPL33331.1 - 0.00027 21.4 69.1 0.0057 17.2 9.6 6.0 7 0 0 7 7 7 4 Human growth factor-like EGF Laminin_EGF PF00053.24 OPL33331.1 - 0.71 10.1 51.1 0.86 9.8 8.0 4.3 1 1 3 4 4 4 0 Laminin EGF domain EGF PF00008.27 OPL33332.1 - 7.3e-06 26.2 23.7 0.00014 22.1 5.2 6.8 6 1 0 6 6 6 4 EGF-like domain EGF_2 PF07974.13 OPL33332.1 - 0.00012 22.3 10.3 0.00012 22.3 10.3 6.7 7 2 0 7 7 7 3 EGF-like domain Y_phosphatase PF00102.27 OPL33334.1 - 1.2e-49 169.0 5.4 1.5e-49 168.7 5.4 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 OPL33334.1 - 2.1e-05 24.4 0.5 4e-05 23.4 0.5 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 OPL33334.1 - 0.00032 20.9 0.5 0.00081 19.5 0.1 2.0 2 1 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 OPL33334.1 - 0.00037 20.5 1.8 0.0013 18.7 0.1 2.1 1 1 1 2 2 2 1 Tyrosine phosphatase family TT1725 PF18324.1 OPL33334.1 - 0.014 15.5 1.5 0.29 11.2 0.2 2.3 2 0 0 2 2 2 0 Hypothetical protein TT1725 Myosin_head PF00063.21 OPL33336.1 - 9.5e-68 229.0 12.1 4.2e-67 226.9 12.1 1.9 1 1 0 1 1 1 1 Myosin head (motor domain) Methyltransf_22 PF13383.6 OPL33337.1 - 4.2e-09 36.3 0.3 6.2e-09 35.8 0.3 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 OPL33337.1 - 0.00065 19.8 0.1 0.0028 17.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase FkbM domain TetR_C_23 PF17931.1 OPL33338.1 - 0.022 14.9 0.6 0.072 13.2 0.1 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain RRM_occluded PF16842.5 OPL33338.1 - 0.054 13.4 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif Stevor PF17410.2 OPL33338.1 - 4.8 6.6 12.6 11 5.5 12.6 1.5 1 1 0 1 1 1 0 Subtelomeric Variable Open Reading frame ApoC-I PF04691.12 OPL33339.1 - 0.016 15.2 0.7 0.73 9.8 0.0 3.4 4 0 0 4 4 4 0 Apolipoprotein C-I (ApoC-1) Baculo_PEP_C PF04513.12 OPL33339.1 - 0.053 13.6 0.2 0.3 11.1 0.0 2.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vps4_C PF09336.10 OPL33339.1 - 0.12 12.4 0.0 0.38 10.8 0.0 1.8 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain GPDPase_memb PF10110.9 OPL33340.1 - 0.31 9.8 0.8 0.41 9.4 0.8 1.1 1 0 0 1 1 1 0 Membrane domain of glycerophosphoryl diester phosphodiesterase HEPN_DZIP3 PF18738.1 OPL33341.1 - 4.3e-09 36.3 0.1 1.4e-07 31.3 0.1 2.6 1 1 0 1 1 1 1 DZIP3/ hRUL138-like HEPN Glyco_hydro_1 PF00232.18 OPL33341.1 - 0.0052 15.3 0.0 0.0066 14.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 DUF948 PF06103.11 OPL33341.1 - 0.029 14.6 0.1 0.055 13.7 0.1 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Lectin_C PF00059.21 OPL33342.1 - 0.00011 22.8 0.2 0.00017 22.3 0.0 1.4 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.12 OPL33342.1 - 0.0024 17.5 0.1 0.0029 17.3 0.1 1.1 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Ldl_recept_a PF00057.18 OPL33343.1 - 2.4e-17 62.8 39.7 2.4e-11 43.7 13.3 2.2 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 OPL33343.1 - 4.8e-08 33.0 16.3 6.4e-08 32.6 16.3 1.1 1 0 0 1 1 1 1 Glucosidase II beta subunit-like DED PF01335.21 OPL33344.1 - 5.6e-13 49.0 1.7 1.1e-12 48.1 1.7 1.4 1 0 0 1 1 1 1 Death effector domain PYRIN PF02758.16 OPL33344.1 - 0.08 13.1 0.6 0.14 12.4 0.6 1.4 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain Tom37_C PF11801.8 OPL33344.1 - 0.12 12.4 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 Tom37 C-terminal domain Cadherin PF00028.17 OPL33345.1 - 1.1e-07 32.2 9.9 0.0011 19.3 0.1 4.5 4 2 1 5 5 5 2 Cadherin domain Cadherin_3 PF16184.5 OPL33345.1 - 0.0006 19.8 4.3 0.019 15.0 0.1 3.1 3 1 0 3 3 3 2 Cadherin-like Cadherin_pro PF08758.11 OPL33345.1 - 0.0034 17.5 0.2 2.2 8.5 0.1 3.9 4 0 0 4 4 4 1 Cadherin prodomain like Cadherin PF00028.17 OPL33346.1 - 3.6e-08 33.8 1.1 4.5e-08 33.4 1.1 1.2 1 0 0 1 1 1 1 Cadherin domain Cadherin_2 PF08266.12 OPL33346.1 - 0.06 13.2 0.0 0.093 12.6 0.0 1.3 1 0 0 1 1 1 0 Cadherin-like Methyltransf_25 PF13649.6 OPL33347.1 - 1.8e-12 47.8 0.0 5.6e-12 46.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 OPL33347.1 - 5.6e-12 46.2 0.1 1.4e-10 41.7 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 OPL33347.1 - 6.2e-08 33.3 0.0 7.8e-07 29.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 OPL33347.1 - 1.1e-06 28.5 0.1 4.6e-06 26.5 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 OPL33347.1 - 0.00032 20.6 0.0 0.00042 20.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 OPL33347.1 - 0.00057 19.3 0.0 0.0009 18.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.20 OPL33347.1 - 0.0036 16.4 0.0 0.0062 15.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DREV PF05219.12 OPL33347.1 - 0.0039 16.3 0.1 0.024 13.7 0.1 1.9 1 1 0 1 1 1 1 DREV methyltransferase FtsJ PF01728.19 OPL33347.1 - 0.037 14.2 0.0 0.1 12.7 0.0 1.7 2 0 0 2 2 2 0 FtsJ-like methyltransferase Rho_GDI PF02115.17 OPL33348.1 - 0.068 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor P2X_receptor PF00864.19 OPL33349.1 - 5.7e-69 232.9 1.0 6.8e-69 232.7 1.0 1.0 1 0 0 1 1 1 1 ATP P2X receptor G0-G1_switch_2 PF15103.6 OPL33349.1 - 0.14 12.6 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 Recep_L_domain PF01030.24 OPL33350.1 - 8.5e-16 58.1 0.0 1.4e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Receptor L domain Pox_G9-A16 PF03003.16 OPL33350.1 - 0.024 14.3 0.8 4.9 6.9 0.0 2.2 2 0 0 2 2 2 0 Pox virus entry-fusion-complex G9/A16 Pkinase PF00069.25 OPL33352.1 - 9.7e-34 116.9 0.1 1.3e-33 116.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 OPL33352.1 - 3.4e-28 98.6 0.1 5.4e-28 98.0 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase RVT_1 PF00078.27 OPL33352.1 - 1.9e-05 24.3 0.0 3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Kdo PF06293.14 OPL33352.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DEP PF00610.21 OPL33353.1 - 9.1e-18 64.1 0.0 2.1e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FYVE PF01363.21 OPL33353.1 - 7e-17 61.3 12.5 7e-17 61.3 12.5 1.7 2 0 0 2 2 2 1 FYVE zinc finger Zip PF02535.22 OPL33354.1 - 1.5e-60 205.2 19.1 3e-60 204.2 19.1 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter Nup160 PF11715.8 OPL33354.1 - 0.22 10.1 0.0 0.35 9.5 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 HSP70 PF00012.20 OPL33355.1 - 5.6e-15 54.5 0.0 1.8e-14 52.9 0.0 1.6 1 1 0 1 1 1 1 Hsp70 protein StbA PF06406.11 OPL33355.1 - 0.029 13.6 0.1 0.7 9.1 0.0 2.2 2 0 0 2 2 2 0 StbA protein Tyr-DNA_phospho PF06087.12 OPL33355.1 - 0.093 11.6 0.2 0.14 11.0 0.2 1.2 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase MFS_1 PF07690.16 OPL33357.1 - 3.3e-10 39.4 1.0 3.7e-10 39.3 1.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily LacY_symp PF01306.19 OPL33357.1 - 0.0014 17.5 1.0 0.002 17.0 1.0 1.3 1 0 0 1 1 1 1 LacY proton/sugar symporter CmcI PF04989.12 OPL33357.1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Cephalosporin hydroxylase Macro PF01661.21 OPL33359.1 - 1.6e-47 160.4 5.7 8.8e-30 103.2 0.3 3.4 3 0 0 3 3 3 2 Macro domain SLS PF14611.6 OPL33359.1 - 0.0033 17.3 12.7 0.098 12.5 0.4 3.6 2 1 1 3 3 3 2 Mitochondrial inner-membrane-bound regulator Alba PF01918.21 OPL33359.1 - 0.023 14.5 1.3 3.2 7.6 0.1 4.0 2 1 1 3 3 3 0 Alba SAM_Exu PF18609.1 OPL33359.1 - 0.038 14.1 3.3 0.049 13.7 0.1 2.9 3 0 0 3 3 3 0 Exuperantia SAM-like domain DED PF01335.21 OPL33359.1 - 0.061 13.6 3.2 7 7.0 0.8 3.0 2 0 0 2 2 2 0 Death effector domain DUF5082 PF16888.5 OPL33359.1 - 0.33 11.2 5.9 0.36 11.1 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) C1q PF00386.21 OPL33360.1 - 5.9e-16 58.8 0.2 6.9e-16 58.6 0.2 1.1 1 0 0 1 1 1 1 C1q domain TNF PF00229.18 OPL33360.1 - 0.064 13.2 0.1 0.11 12.5 0.1 1.4 1 1 0 1 1 1 0 TNF(Tumour Necrosis Factor) family Aldedh PF00171.22 OPL33362.1 - 6.1e-98 328.3 0.0 7.3e-98 328.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RNB PF00773.19 OPL33363.1 - 2.9e-75 253.6 0.2 2.2e-41 142.3 0.1 2.1 1 1 1 2 2 2 2 RNB domain Rrp44_S1 PF17215.3 OPL33363.1 - 2.1e-08 34.0 0.3 4.6e-08 32.9 0.3 1.5 1 0 0 1 1 1 1 S1 domain Dis3l2_C_term PF17877.1 OPL33363.1 - 0.014 15.7 0.0 0.035 14.4 0.0 1.7 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal DUF1207 PF06727.11 OPL33363.1 - 0.062 12.2 0.0 0.2 10.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1207) Y_phosphatase PF00102.27 OPL33367.1 - 2.1e-69 233.7 12.9 5.6e-30 104.7 2.9 3.4 2 1 1 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 OPL33367.1 - 0.00012 21.8 2.4 0.00024 20.9 0.4 2.5 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 OPL33367.1 - 0.0022 18.0 0.1 0.0067 16.4 0.0 1.9 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 OPL33367.1 - 0.0029 17.7 0.5 0.015 15.4 0.0 2.5 1 1 1 2 2 2 1 Inositol hexakisphosphate RecG_N PF17190.4 OPL33368.1 - 0.013 16.2 2.3 0.021 15.5 1.5 1.8 2 0 0 2 2 2 0 RecG N-terminal helical domain WAP PF00095.21 OPL33370.1 - 1 9.8 35.8 0.49 10.8 7.7 3.2 3 0 0 3 3 3 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' WAP PF00095.21 OPL33371.1 - 0.0014 19.0 35.2 0.086 13.2 9.1 3.2 3 0 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' Orthopox_F7 PF05813.12 OPL33372.1 - 0.016 15.3 0.2 0.026 14.6 0.2 1.4 1 0 0 1 1 1 0 Orthopoxvirus F7 protein BCHF PF07284.11 OPL33372.1 - 0.12 12.4 1.6 0.17 11.9 1.6 1.2 1 0 0 1 1 1 0 2-vinyl bacteriochlorophyllide hydratase (BCHF) DUF1361 PF07099.11 OPL33372.1 - 0.28 11.1 1.2 0.36 10.8 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1361) PhyH PF05721.13 OPL33374.1 - 0.015 15.6 0.0 0.033 14.5 0.0 1.6 1 1 1 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) UvrD-helicase PF00580.21 OPL33375.1 - 4.7e-08 32.9 2.6 4.7e-08 32.9 2.6 3.2 2 1 0 2 2 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 OPL33375.1 - 2.2e-07 30.6 0.0 8.9e-05 22.0 0.0 3.6 2 2 1 3 3 2 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 OPL33375.1 - 3e-07 30.2 0.0 0.0056 16.5 0.0 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 OPL33375.1 - 0.00039 20.8 0.0 0.0017 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain TPR_1 PF00515.28 OPL33375.1 - 0.0011 18.7 14.6 0.036 13.9 0.0 5.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 OPL33375.1 - 0.0017 19.0 3.0 13 7.0 1.0 5.0 4 2 2 6 6 6 0 Tetratricopeptide repeat Acetyltransf_19 PF18015.1 OPL33375.1 - 0.0069 16.6 1.2 1.6 9.0 0.2 2.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Clathrin PF00637.20 OPL33375.1 - 0.012 15.4 9.6 0.14 12.0 2.9 4.1 2 1 2 4 4 4 0 Region in Clathrin and VPS TPR_2 PF07719.17 OPL33375.1 - 0.021 14.9 15.0 2.2 8.6 0.0 6.0 3 1 2 6 6 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 OPL33375.1 - 0.03 14.3 3.6 2 8.6 0.1 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 OPL33375.1 - 0.28 11.5 5.3 23 5.4 0.8 4.1 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 OPL33375.1 - 1.5 9.2 17.5 8 7.0 0.0 6.0 4 1 3 7 7 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 OPL33375.1 - 3 8.4 5.5 38 4.9 0.2 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat Vps39_1 PF10366.9 OPL33375.1 - 5.3 7.4 8.9 2.1 8.7 1.9 3.5 2 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 1 TPR_6 PF13174.6 OPL33375.1 - 9.1 7.2 9.4 42 5.1 1.0 5.3 4 1 1 6 6 6 0 Tetratricopeptide repeat FAD_binding_3 PF01494.19 OPL33376.1 - 1.3e-10 41.1 0.0 1.9e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 OPL33376.1 - 0.00055 19.1 0.1 0.00093 18.3 0.1 1.4 1 0 0 1 1 1 1 Squalene epoxidase Helicase_C PF00271.31 OPL33377.1 - 3.3e-19 69.3 0.5 1.6e-18 67.1 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HA2 PF04408.23 OPL33377.1 - 3.1e-07 30.7 1.0 7.5e-07 29.4 0.1 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) DEAD PF00270.29 OPL33377.1 - 1.1e-05 25.3 1.8 0.076 12.8 0.1 3.1 2 1 1 3 3 3 2 DEAD/DEAH box helicase AAA_22 PF13401.6 OPL33377.1 - 1.3e-05 25.4 0.0 4.2e-05 23.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 OPL33377.1 - 0.0026 17.1 0.0 0.0098 15.3 0.0 1.9 1 0 0 1 1 1 1 KaiC AAA_14 PF13173.6 OPL33377.1 - 0.0058 16.7 2.3 0.011 15.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 OPL33377.1 - 0.015 15.2 0.0 0.039 13.9 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 OPL33377.1 - 0.025 14.9 0.2 0.14 12.4 0.2 2.3 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 OPL33377.1 - 0.031 14.8 0.0 0.031 14.8 0.0 3.1 2 1 1 3 3 2 0 AAA domain ABC_tran PF00005.27 OPL33377.1 - 0.13 12.8 2.4 0.26 11.8 0.0 2.6 2 1 0 2 2 2 0 ABC transporter AAA_11 PF13086.6 OPL33377.1 - 0.6 9.8 0.0 0.6 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain PP1_bind PF15276.6 OPL33378.1 - 1.3e-14 54.3 4.9 1.3e-14 54.3 4.9 13.9 12 3 4 17 17 17 2 Protein phosphatase 1 binding Kunitz_BPTI PF00014.23 OPL33379.1 - 5.1e-19 68.3 8.3 8.8e-19 67.5 8.3 1.4 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain MFS_1 PF07690.16 OPL33380.1 - 5.2e-07 28.9 18.2 5.2e-07 28.9 18.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily P_proprotein PF01483.20 OPL33382.1 - 1.6e-18 66.5 0.0 1.8e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Proprotein convertase P-domain SEFIR PF08357.11 OPL33383.1 - 0.0056 17.0 0.1 0.015 15.6 0.1 1.7 1 1 0 1 1 1 1 SEFIR domain TIR_2 PF13676.6 OPL33383.1 - 0.17 12.5 0.0 0.33 11.6 0.0 1.5 1 0 0 1 1 1 0 TIR domain CUB PF00431.20 OPL33384.1 - 0.00069 19.9 0.0 0.0015 18.9 0.0 1.6 1 1 0 1 1 1 1 CUB domain fn3 PF00041.21 OPL33385.1 - 1.5e-09 38.1 2.7 2e-08 34.5 0.2 2.9 3 0 0 3 3 3 1 Fibronectin type III domain Ig_3 PF13927.6 OPL33385.1 - 0.0018 18.8 0.4 0.072 13.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain F5_F8_type_C PF00754.25 OPL33385.1 - 0.098 12.8 0.6 0.25 11.5 0.2 1.9 2 0 0 2 2 2 0 F5/8 type C domain DUF3299 PF11736.8 OPL33385.1 - 0.1 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3299) I-set PF07679.16 OPL33385.1 - 0.11 12.6 0.1 1.1 9.4 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin I-set domain C8 PF08742.11 OPL33386.1 - 0.01 16.3 0.1 0.01 16.3 0.1 2.2 2 1 1 3 3 3 0 C8 domain E3_UbLigase_RBR PF18091.1 OPL33387.1 - 5.8e-31 106.5 0.3 2.2e-30 104.6 0.2 2.0 2 0 0 2 2 2 1 E3 Ubiquitin Ligase RBR C-terminal domain IBR PF01485.21 OPL33387.1 - 1.2e-06 28.7 10.6 1.2e-06 28.7 10.6 2.5 2 1 1 3 3 3 1 IBR domain, a half RING-finger domain zinc_ribbon_4 PF13717.6 OPL33387.1 - 0.023 14.6 8.0 0.52 10.3 0.0 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Tyrosinase PF00264.20 OPL33388.1 - 1e-29 104.5 4.0 2.9e-15 57.1 0.0 2.6 1 1 1 2 2 2 2 Common central domain of tyrosinase Pentapeptide_2 PF01469.18 OPL33388.1 - 0.39 10.6 46.1 1.1 9.2 46.1 1.8 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) Fibrinogen_C PF00147.18 OPL33389.1 - 1.7e-24 86.9 5.4 2e-24 86.6 5.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CENP-F_leu_zip PF10473.9 OPL33390.1 - 7e-07 29.4 14.5 1.8e-05 24.8 4.9 2.3 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 OPL33390.1 - 3.4e-06 27.1 13.7 0.00014 21.9 2.1 3.4 1 1 2 3 3 3 2 Protein of unknown function (DUF1664) Tropomyosin PF00261.20 OPL33390.1 - 8.1e-06 25.4 7.9 0.00077 18.9 7.9 2.4 1 1 0 1 1 1 1 Tropomyosin Laminin_II PF06009.12 OPL33390.1 - 2.9e-05 24.1 14.8 0.047 13.7 0.5 3.7 1 1 1 3 3 3 2 Laminin Domain II Snapin_Pallidin PF14712.6 OPL33390.1 - 0.00012 22.5 9.9 0.028 14.8 0.6 4.2 1 1 4 5 5 5 1 Snapin/Pallidin Tropomyosin_1 PF12718.7 OPL33390.1 - 0.0026 17.9 11.1 0.048 13.8 3.8 2.5 1 1 1 2 2 2 1 Tropomyosin like PspA_IM30 PF04012.12 OPL33390.1 - 0.0026 17.4 4.4 0.0062 16.1 1.3 2.9 1 1 1 2 2 2 1 PspA/IM30 family DUF1515 PF07439.11 OPL33390.1 - 0.0076 16.3 3.6 0.013 15.6 0.2 2.7 1 1 2 3 3 3 1 Protein of unknown function (DUF1515) HemX PF04375.14 OPL33390.1 - 0.008 15.5 2.0 0.18 11.1 0.0 2.9 1 1 2 3 3 3 1 HemX, putative uroporphyrinogen-III C-methyltransferase Baculo_PEP_C PF04513.12 OPL33390.1 - 0.0086 16.1 11.9 0.054 13.5 1.1 3.2 1 1 1 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus Myosin_tail_1 PF01576.19 OPL33390.1 - 0.011 13.6 9.2 0.018 12.9 9.2 1.2 1 0 0 1 1 1 0 Myosin tail BST2 PF16716.5 OPL33390.1 - 0.015 15.9 7.0 0.061 13.9 0.1 3.5 1 1 2 4 4 4 0 Bone marrow stromal antigen 2 TPR_MLP1_2 PF07926.12 OPL33390.1 - 0.016 15.3 9.3 0.46 10.6 1.0 4.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Nup88 PF10168.9 OPL33390.1 - 0.024 12.4 9.1 0.027 12.3 1.2 2.1 2 0 0 2 2 2 0 Nuclear pore component DUF16 PF01519.16 OPL33390.1 - 0.027 14.9 17.5 1.5 9.4 0.4 4.4 1 1 2 3 3 3 0 Protein of unknown function DUF16 Lectin_N PF03954.14 OPL33390.1 - 0.033 13.9 11.5 1.5 8.6 1.1 4.0 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain Macoilin PF09726.9 OPL33390.1 - 0.04 12.5 6.6 0.052 12.1 6.6 1.2 1 0 0 1 1 1 0 Macoilin family XhlA PF10779.9 OPL33390.1 - 0.043 14.0 15.7 9.4 6.5 0.0 5.5 1 1 3 5 5 5 0 Haemolysin XhlA Exonuc_VII_L PF02601.15 OPL33390.1 - 0.045 13.3 9.2 5 6.6 9.3 2.2 1 1 0 1 1 1 0 Exonuclease VII, large subunit Sigma70_r1_1 PF03979.14 OPL33390.1 - 0.052 13.6 1.7 0.16 12.1 1.7 1.8 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 HAP1_N PF04849.13 OPL33390.1 - 0.055 12.7 11.5 0.11 11.6 1.3 2.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Laminin_I PF06008.14 OPL33390.1 - 0.063 13.0 10.4 2.2 7.9 5.2 3.1 2 1 1 3 3 3 0 Laminin Domain I Fib_alpha PF08702.10 OPL33390.1 - 0.063 13.5 15.9 0.36 11.0 4.2 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF724 PF05266.14 OPL33390.1 - 0.084 12.7 13.2 0.53 10.1 0.1 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF724) BRE1 PF08647.11 OPL33390.1 - 0.11 12.6 0.1 0.11 12.6 0.1 3.6 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase NB PF04159.13 OPL33390.1 - 0.13 12.3 0.1 6 7.0 0.0 2.5 2 0 0 2 2 2 0 NB glycoprotein NPV_P10 PF05531.12 OPL33390.1 - 0.16 12.5 17.0 2.3 8.7 0.4 4.9 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 OPL33390.1 - 0.17 12.3 13.8 10 6.6 0.1 5.1 3 3 2 5 5 5 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 OPL33390.1 - 0.18 12.4 8.3 24 5.5 1.3 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region Filament PF00038.21 OPL33390.1 - 0.24 10.9 12.9 2.4 7.7 12.9 2.5 1 1 0 1 1 1 0 Intermediate filament protein LPP PF04728.13 OPL33390.1 - 0.25 11.8 12.1 0.46 10.9 0.0 4.2 6 0 0 6 6 4 0 Lipoprotein leucine-zipper PI3K_P85_iSH2 PF16454.5 OPL33390.1 - 0.27 10.8 10.7 0.084 12.5 1.2 2.8 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Fzo_mitofusin PF04799.13 OPL33390.1 - 0.31 10.6 6.5 3.5 7.2 1.5 3.4 2 1 1 3 3 3 0 fzo-like conserved region ERM PF00769.19 OPL33390.1 - 0.33 10.7 8.5 0.6 9.9 7.0 2.1 1 1 0 1 1 1 0 Ezrin/radixin/moesin family CLZ PF16526.5 OPL33390.1 - 0.34 11.3 7.1 2.5 8.5 0.2 4.0 3 2 2 5 5 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF948 PF06103.11 OPL33390.1 - 0.46 10.8 7.6 1.2 9.4 0.4 3.9 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Uds1 PF15456.6 OPL33390.1 - 0.91 9.7 5.2 30 4.8 5.2 2.8 1 1 0 1 1 1 0 Up-regulated During Septation DUF1319 PF07028.11 OPL33390.1 - 1.1 9.5 9.9 14 6.0 0.1 4.0 1 1 2 4 4 4 0 Protein of unknown function (DUF1319) DHR10 PF18595.1 OPL33390.1 - 1.2 9.2 8.2 3.6 7.7 2.2 3.1 2 2 1 3 3 3 0 Designed helical repeat protein 10 domain Jnk-SapK_ap_N PF09744.9 OPL33390.1 - 3.1 8.0 11.8 2.7 8.2 0.3 3.3 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 COG5 PF10392.9 OPL33390.1 - 5.1 7.3 8.7 5.1 7.3 0.8 3.1 2 1 1 3 3 3 0 Golgi transport complex subunit 5 DUF2408 PF10303.9 OPL33390.1 - 9.2 6.8 10.5 3.4e+02 1.8 10.4 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) CHCH PF06747.13 OPL33391.1 - 4.2e-07 29.9 4.4 6.3e-07 29.4 4.4 1.3 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.9 OPL33391.1 - 0.00067 19.8 3.0 0.00079 19.5 3.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) GTP_EFTU PF00009.27 OPL33392.1 - 2.7e-23 82.5 0.0 5.9e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 OPL33392.1 - 2.1e-07 31.2 0.2 6.7e-07 29.6 0.2 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 OPL33392.1 - 0.00016 21.9 0.3 0.0012 19.2 0.1 2.5 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 OPL33392.1 - 0.00064 19.8 0.0 0.0025 17.9 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 OPL33392.1 - 0.02 14.6 0.0 7.3 6.3 0.0 3.2 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 OPL33392.1 - 0.048 13.6 0.1 6 6.7 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 OPL33392.1 - 0.21 11.6 2.6 0.7 9.9 0.1 2.7 2 1 0 3 3 3 0 Dynamin family ABC_tran PF00005.27 OPL33392.1 - 0.3 11.6 0.0 0.3 11.6 0.0 2.2 2 1 0 2 2 2 0 ABC transporter TssO PF17561.2 OPL33393.1 - 0.0022 18.1 0.2 0.0035 17.4 0.2 1.3 1 0 0 1 1 1 1 Type VI secretion system, TssO DUF3972 PF13118.6 OPL33393.1 - 0.0054 17.2 0.9 0.008 16.6 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3972) CemA PF03040.14 OPL33393.1 - 0.086 12.8 0.4 0.11 12.4 0.4 1.1 1 0 0 1 1 1 0 CemA family HMMR_C PF15908.5 OPL33393.1 - 0.18 12.1 0.8 0.25 11.6 0.9 1.3 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal F5_F8_type_C PF00754.25 OPL33394.1 - 0.05 13.7 0.0 0.083 13.0 0.0 1.2 1 0 0 1 1 1 0 F5/8 type C domain INTS5_N PF14837.6 OPL33395.1 - 0.025 14.2 0.2 0.028 14.0 0.2 1.1 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus MFS_1 PF07690.16 OPL33396.1 - 5.5e-45 153.8 23.5 2.5e-34 118.8 8.7 2.7 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 OPL33396.1 - 7.8e-11 41.5 10.6 7.8e-11 41.5 10.6 3.6 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.6 OPL33396.1 - 2.7e-06 26.2 9.7 0.0001 21.0 2.3 3.4 4 0 0 4 4 4 2 MFS/sugar transport protein BT1 PF03092.16 OPL33396.1 - 0.00089 17.6 7.9 0.085 11.1 0.0 3.1 3 0 0 3 3 3 3 BT1 family DUF4231 PF14015.6 OPL33396.1 - 0.12 12.9 2.9 1.2 9.6 0.0 3.3 2 2 2 4 4 4 0 Protein of unknown function (DUF4231) MIB_HERC2 PF06701.13 OPL33397.1 - 0.006 16.8 5.3 0.4 10.9 1.5 2.5 2 1 0 2 2 2 2 Mib_herc2 Big_4 PF07532.11 OPL33397.1 - 0.91 9.3 6.3 9.4 6.1 0.4 3.1 2 1 1 3 3 3 0 Bacterial Ig-like domain (group 4) MIEAP PF16026.5 OPL33398.1 - 2.3e-09 37.8 0.0 2.3e-09 37.8 0.0 2.2 2 0 0 2 2 2 1 Mitochondria-eating protein GIT_CC PF16559.5 OPL33398.1 - 0.057 13.3 0.6 0.057 13.3 0.6 2.6 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor S1-P1_nuclease PF02265.16 OPL33398.1 - 0.082 12.7 2.1 0.15 11.8 2.1 1.5 1 0 0 1 1 1 0 S1/P1 Nuclease UPF0242 PF06785.11 OPL33398.1 - 0.14 12.3 19.4 0.25 11.4 19.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GIDA_assoc PF13932.6 OPL33398.1 - 0.21 11.7 9.2 0.22 11.7 8.1 1.5 2 0 0 2 2 2 0 GidA associated domain Cnn_1N PF07989.11 OPL33398.1 - 0.44 10.7 15.8 1.1 9.5 14.4 2.4 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF1465 PF07323.12 OPL33398.1 - 0.48 10.3 7.4 1.1 9.0 7.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1465) DUF1664 PF07889.12 OPL33398.1 - 1.7 8.7 11.8 1 9.4 7.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) RPAP1_C PF08620.10 OPL33399.1 - 1.4e-26 92.4 0.1 3.2e-26 91.2 0.1 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 OPL33399.1 - 1.9e-15 56.4 0.5 4.2e-15 55.2 0.5 1.6 1 0 0 1 1 1 1 RPAP1-like, N-terminal HEAT PF02985.22 OPL33399.1 - 0.019 15.2 0.5 8.2 7.0 0.4 2.8 2 0 0 2 2 2 0 HEAT repeat MIP-T3 PF10243.9 OPL33399.1 - 0.081 12.9 0.2 0.3 11.1 0.2 1.9 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CH-like domain Arm PF00514.23 OPL33399.1 - 0.6 10.2 6.7 0.15 12.1 0.9 3.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat VWA PF00092.28 OPL33400.1 - 4.8e-58 196.3 5.0 9.7e-30 104.1 0.8 2.6 3 0 0 3 3 3 2 von Willebrand factor type A domain Ig_3 PF13927.6 OPL33400.1 - 1.2e-27 96.3 2.9 8.5e-13 48.7 0.2 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL33400.1 - 1.2e-20 73.4 0.2 1.7e-09 37.6 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 OPL33400.1 - 4e-20 71.8 1.5 3.8e-10 39.8 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain VWA_2 PF13519.6 OPL33400.1 - 1.9e-19 70.3 3.1 7.4e-09 36.2 0.3 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain V-set PF07686.17 OPL33400.1 - 5.3e-14 52.3 2.9 1.5e-05 25.1 0.2 4.0 2 2 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 OPL33400.1 - 1.3e-13 51.1 1.2 5.5e-06 26.6 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain VWA_3 PF13768.6 OPL33400.1 - 0.00026 21.0 0.1 0.067 13.1 0.0 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain Adeno_E3_CR1 PF02440.15 OPL33400.1 - 0.00039 20.1 0.0 0.026 14.3 0.0 2.3 2 0 0 2 2 2 1 Adenovirus E3 region protein CR1 Izumo-Ig PF16706.5 OPL33400.1 - 0.0012 18.8 0.0 1.1 9.3 0.0 3.4 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 OPL33400.1 - 0.0013 18.3 0.0 0.3 10.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain C2-set PF05790.15 OPL33400.1 - 0.0077 16.4 0.2 4.9 7.4 0.0 3.4 4 0 0 4 4 4 1 Immunoglobulin C2-set domain Toprim_3 PF13362.6 OPL33400.1 - 0.011 16.1 1.2 5.6 7.4 0.1 2.8 3 0 0 3 3 2 0 Toprim domain DUF1533 PF07550.11 OPL33400.1 - 0.041 13.8 0.0 0.13 12.1 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1533) Ig_C17orf99 PF17736.1 OPL33400.1 - 0.063 13.3 0.0 7.7 6.6 0.0 2.7 2 0 0 2 2 2 0 C17orf99 Ig domain Receptor_2B4 PF11465.8 OPL33400.1 - 0.073 13.3 0.0 1.2 9.3 0.0 2.6 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 C2-set_2 PF08205.12 OPL33400.1 - 0.089 12.9 0.1 2.8 8.1 0.0 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Kunitz_BPTI PF00014.23 OPL33402.1 - 8.2e-20 70.8 9.7 1e-19 70.5 9.7 1.2 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain VWA PF00092.28 OPL33403.1 - 1.8e-25 90.2 2.8 1.8e-25 90.2 2.8 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL33403.1 - 4.1e-13 49.9 0.3 8.1e-13 49.0 0.3 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Ig_3 PF13927.6 OPL33403.1 - 2.3e-07 31.3 0.3 7.1e-07 29.7 0.3 1.9 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 OPL33403.1 - 1e-05 25.6 0.1 2.6e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL33403.1 - 1.4e-05 25.3 0.4 4e-05 23.9 0.4 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL33403.1 - 0.00035 20.6 0.2 0.0017 18.4 0.2 2.1 1 1 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 OPL33403.1 - 0.039 14.1 0.7 1.8 8.8 0.4 2.5 1 1 1 2 2 2 0 Immunoglobulin V-set domain VWA_CoxE PF05762.14 OPL33403.1 - 0.049 13.0 0.2 0.09 12.2 0.2 1.4 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein Ig_4 PF16680.5 OPL33403.1 - 0.34 11.2 1.4 0.48 10.7 0.1 2.0 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Transglut_N PF00868.20 OPL33405.1 - 6e-33 113.7 0.0 1.1e-32 112.9 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.19 OPL33405.1 - 2.4e-14 53.8 0.2 4.4e-14 52.9 0.2 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily FYVE PF01363.21 OPL33406.1 - 0.036 14.2 2.1 0.093 12.9 2.1 1.7 1 0 0 1 1 1 0 FYVE zinc finger Opy2 PF09463.10 OPL33406.1 - 0.046 14.0 4.1 0.1 12.9 4.1 1.6 1 0 0 1 1 1 0 Opy2 protein zf-B_box PF00643.24 OPL33406.1 - 0.057 13.6 6.2 0.15 12.2 6.2 1.8 1 0 0 1 1 1 0 B-box zinc finger U1snRNP70_N PF12220.8 OPL33406.1 - 0.061 14.0 4.5 35 5.1 1.3 3.8 3 1 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Allexi_40kDa PF05549.11 OPL33406.1 - 0.93 8.9 10.7 0.029 13.9 2.9 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein Mt_ATP-synt_D PF05873.12 OPL33406.1 - 1.1 9.1 6.5 2.2 8.1 2.9 2.6 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) C1_4 PF07975.12 OPL33406.1 - 9.2 6.6 9.9 62 3.9 9.9 2.5 1 1 0 1 1 1 0 TFIIH C1-like domain Tmem26 PF09772.9 OPL33407.1 - 4.3e-55 187.1 0.5 5.7e-55 186.7 0.5 1.1 1 0 0 1 1 1 1 Transmembrane protein 26 DUF4885 PF16226.5 OPL33407.1 - 0.051 12.6 0.0 0.078 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4885) Acetyltransf_1 PF00583.25 OPL33408.1 - 1e-10 41.8 0.0 1.2e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 OPL33408.1 - 3.4e-09 37.0 0.1 4.5e-09 36.6 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 OPL33408.1 - 1.2e-07 31.7 0.0 1.6e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Kringle PF00051.18 OPL33409.1 - 2.2e-19 69.5 5.0 3.5e-19 68.9 5.0 1.3 1 0 0 1 1 1 1 Kringle domain HSP70 PF00012.20 OPL33410.1 - 2.8e-14 52.2 0.2 3.9e-14 51.8 0.2 1.2 1 0 0 1 1 1 1 Hsp70 protein StbA PF06406.11 OPL33410.1 - 0.025 13.8 0.0 0.11 11.7 0.0 2.0 2 0 0 2 2 2 0 StbA protein MreB_Mbl PF06723.13 OPL33410.1 - 0.078 11.8 1.2 0.18 10.6 0.1 2.0 2 1 1 3 3 3 0 MreB/Mbl protein FtsA PF14450.6 OPL33410.1 - 0.24 11.9 0.4 0.74 10.3 0.4 1.8 1 0 0 1 1 1 0 Cell division protein FtsA DUF1857 PF08982.11 OPL33411.1 - 0.087 12.7 0.0 0.11 12.3 0.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1857) I-set PF07679.16 OPL33412.1 - 1.7e-28 98.5 0.1 9e-14 51.3 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33412.1 - 1.5e-21 76.7 0.4 1.2e-09 38.6 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL33412.1 - 3.1e-18 65.7 1.3 3.7e-09 36.6 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 OPL33412.1 - 3e-12 46.7 0.2 9.1e-05 22.7 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 OPL33412.1 - 3.5e-12 46.4 1.8 0.0098 16.1 0.2 4.1 2 2 1 3 3 3 3 Immunoglobulin V-set domain C1-set PF07654.15 OPL33412.1 - 0.00032 21.0 0.2 0.24 11.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin C1-set domain NID PF07292.13 OPL33412.1 - 0.00085 19.9 0.1 0.5 11.1 0.0 2.2 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) Me-amine-dh_L PF02975.14 OPL33412.1 - 0.001 19.6 0.0 0.3 11.6 0.0 2.2 2 0 0 2 2 2 1 Methylamine dehydrogenase, L chain Receptor_2B4 PF11465.8 OPL33412.1 - 0.0034 17.6 0.1 3.6 7.8 0.0 2.3 2 0 0 2 2 2 2 Natural killer cell receptor 2B4 Pox_G9-A16 PF03003.16 OPL33412.1 - 0.0098 15.6 0.8 0.31 10.8 0.2 2.3 2 0 0 2 2 2 1 Pox virus entry-fusion-complex G9/A16 Izumo-Ig PF16706.5 OPL33412.1 - 0.018 15.1 4.4 2.5 8.2 0.3 3.4 2 2 0 2 2 2 0 Izumo-like Immunoglobulin domain ComP_DUS PF16732.5 OPL33412.1 - 0.096 13.6 0.9 4.3 8.3 0.1 2.2 2 0 0 2 2 2 0 Type IV minor pilin ComP, DNA uptake sequence receptor nos_propeller PF18764.1 OPL33412.1 - 0.13 12.2 0.0 6.4 6.8 0.0 2.5 2 0 0 2 2 2 0 Nitrous oxide reductase propeller repeat Tudor-knot PF11717.8 OPL33412.1 - 0.16 11.9 0.2 2.1 8.3 0.0 2.3 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain DUF4304 PF14137.6 OPL33412.1 - 0.17 12.0 2.1 1.1 9.5 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4304) PALP PF00291.25 OPL33413.1 - 3.1e-48 164.7 0.2 3.7e-48 164.4 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Mab-21 PF03281.14 OPL33414.1 - 1.8e-05 24.2 0.2 3.8e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 Mab-21 protein RlaP PF10127.9 OPL33414.1 - 0.00099 18.8 0.0 0.0024 17.5 0.0 1.6 2 0 0 2 2 2 1 RNA repair pathway DNA polymerase beta family NTP_transf_2 PF01909.23 OPL33414.1 - 0.0047 17.2 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain HEPN_Toprim_N PF18871.1 OPL33414.1 - 0.08 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 HEPN/Toprim N-terminal domain 1 Ig_3 PF13927.6 OPL33415.1 - 0.00011 22.8 2.2 0.00012 22.6 1.1 1.7 2 0 0 2 2 2 1 Immunoglobulin domain GPI-anchored PF10342.9 OPL33415.1 - 0.0034 18.1 0.1 0.0086 16.8 0.1 1.6 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family V-set PF07686.17 OPL33415.1 - 0.014 15.6 2.7 0.024 14.8 0.9 2.0 1 1 1 2 2 2 0 Immunoglobulin V-set domain I-set PF07679.16 OPL33415.1 - 0.04 14.0 1.2 0.16 12.1 0.5 2.2 2 1 0 2 2 2 0 Immunoglobulin I-set domain EVC2_like PF12297.8 OPL33416.1 - 0.021 13.5 0.1 0.028 13.1 0.1 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein BPD_transp_2 PF02653.16 OPL33416.1 - 0.074 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component PARP PF00644.20 OPL33417.1 - 4.3e-09 36.2 0.1 6.7e-09 35.6 0.1 1.4 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Macro PF01661.21 OPL33417.1 - 5.1e-05 23.3 0.0 0.00017 21.6 0.0 1.9 2 0 0 2 2 2 1 Macro domain Macro PF01661.21 OPL33418.1 - 2.5e-08 34.0 0.0 0.00012 22.1 0.1 2.3 2 0 0 2 2 2 2 Macro domain GFO_IDH_MocA PF01408.22 OPL33419.1 - 0.00027 21.7 0.0 0.0004 21.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 OPL33419.1 - 0.12 13.0 0.0 0.21 12.3 0.0 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 OPL33419.1 - 0.16 12.6 0.0 0.26 11.9 0.0 1.3 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent WSC PF01822.19 OPL33420.1 - 3.5e-05 23.9 0.2 5.4e-05 23.3 0.2 1.3 1 0 0 1 1 1 1 WSC domain PAN_1 PF00024.26 OPL33420.1 - 0.0058 16.6 0.6 0.011 15.6 0.6 1.5 1 0 0 1 1 1 1 PAN domain PAN_2 PF08276.11 OPL33420.1 - 0.037 14.2 0.2 0.067 13.3 0.2 1.4 1 0 0 1 1 1 0 PAN-like domain PB1 PF00564.24 OPL33421.1 - 0.0046 16.9 0.6 0.0046 16.9 0.6 2.0 3 0 0 3 3 3 1 PB1 domain CLCA PF08434.11 OPL33422.1 - 4e-18 65.7 1.6 4.9e-18 65.4 1.6 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal Pkinase_Tyr PF07714.17 OPL33423.1 - 4.3e-09 36.0 0.0 1.9e-06 27.4 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase fn3 PF00041.21 OPL33423.1 - 9.3e-07 29.1 1.5 4.9e-05 23.6 0.0 3.5 3 0 0 3 3 3 1 Fibronectin type III domain Pkinase PF00069.25 OPL33423.1 - 0.071 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain LptF_LptG PF03739.14 OPL33423.1 - 0.078 11.8 0.7 0.14 11.0 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG GBS_Bsp-like PF08481.10 OPL33423.1 - 4.8 7.4 6.6 2.7 8.2 0.7 3.2 3 0 0 3 3 3 0 GBS Bsp-like repeat OAS1_C PF10421.9 OPL33424.1 - 1.8e-12 47.1 0.3 6.5e-12 45.3 0.3 1.7 1 1 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus tRNA_NucTransf2 PF09249.11 OPL33424.1 - 0.0045 17.2 0.0 0.0095 16.2 0.0 1.6 1 1 0 1 1 1 1 tRNA nucleotidyltransferase, second domain BIR PF00653.21 OPL33425.1 - 9.9e-36 122.2 7.5 6.9e-20 71.5 1.5 3.0 3 0 0 3 3 3 2 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 OPL33425.1 - 7.7e-13 48.1 6.8 7.7e-13 48.1 6.8 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL33425.1 - 0.00057 19.7 8.2 0.00057 19.7 8.2 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 OPL33425.1 - 0.008 16.1 6.9 0.008 16.1 6.9 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 OPL33425.1 - 0.009 16.3 9.6 0.009 16.3 9.6 2.6 3 0 0 3 3 3 1 Ring finger domain Pkinase_Tyr PF07714.17 OPL33427.1 - 5.8e-80 268.3 0.0 7.9e-80 267.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 OPL33427.1 - 1.6e-42 145.7 0.0 2.3e-42 145.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 OPL33427.1 - 6.2e-20 71.1 0.0 1.3e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Fructosamin_kin PF03881.14 OPL33427.1 - 0.0023 17.2 0.0 0.0035 16.6 0.0 1.2 1 0 0 1 1 1 1 Fructosamine kinase Haspin_kinase PF12330.8 OPL33427.1 - 0.014 14.4 0.0 0.023 13.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain OPA3 PF07047.12 OPL33428.1 - 2.9e-27 94.9 1.7 2.1e-26 92.1 1.7 1.9 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Fibrinogen_C PF00147.18 OPL33429.1 - 2.5e-34 119.0 1.8 3.1e-34 118.7 1.8 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Lectin_C PF00059.21 OPL33430.1 - 0.055 14.2 3.0 0.81 10.4 1.3 3.0 2 0 0 2 2 2 0 Lectin C-type domain Orf78 PF06024.12 OPL33431.1 - 0.061 13.6 1.3 0.078 13.3 1.3 1.2 1 0 0 1 1 1 0 Orf78 (ac78) TMEM154 PF15102.6 OPL33431.1 - 0.3 11.0 1.5 0.43 10.5 1.5 1.2 1 0 0 1 1 1 0 TMEM154 protein family HSP70 PF00012.20 OPL33432.1 - 5e-15 54.7 0.2 3e-13 48.9 0.1 2.3 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 OPL33432.1 - 3.8e-06 25.9 0.1 0.0047 15.8 0.0 3.1 1 1 2 3 3 3 2 MreB/Mbl protein Borrelia_lipo_1 PF05714.11 OPL33432.1 - 0.02 14.7 1.2 0.02 14.7 1.2 1.9 2 0 0 2 2 2 0 Borrelia burgdorferi virulent strain associated lipoprotein AAA PF00004.29 OPL33433.1 - 5.9e-10 39.7 0.0 0.00074 20.0 0.0 3.1 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 OPL33433.1 - 8.9e-08 32.2 0.1 2.5e-05 24.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 OPL33433.1 - 3.3e-06 26.8 0.1 0.073 12.6 0.0 2.8 2 0 0 2 2 2 2 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 OPL33433.1 - 0.00011 22.3 0.3 0.024 14.8 0.0 3.3 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_16 PF13191.6 OPL33433.1 - 0.00029 21.2 0.1 0.077 13.4 0.0 3.8 3 0 0 3 3 3 1 AAA ATPase domain ABC_tran PF00005.27 OPL33433.1 - 0.00037 21.0 0.1 0.018 15.5 0.0 3.0 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 OPL33433.1 - 0.00078 19.7 0.0 0.31 11.3 0.0 3.5 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 OPL33433.1 - 0.0045 17.0 0.0 0.086 12.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 OPL33433.1 - 0.012 16.0 0.0 2.8 8.4 0.0 3.3 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 OPL33433.1 - 0.018 14.9 0.6 0.72 9.7 0.0 3.7 5 0 0 5 5 5 0 NACHT domain AAA_18 PF13238.6 OPL33433.1 - 0.081 13.5 0.1 0.98 10.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 OPL33433.1 - 0.092 12.4 0.0 0.81 9.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain C1q PF00386.21 OPL33434.1 - 1e-05 25.7 0.0 5.6e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 C1q domain DUF4986 PF16375.5 OPL33434.1 - 0.048 14.3 0.0 0.062 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function zf-CHC2 PF01807.20 OPL33435.1 - 0.026 14.3 1.0 0.084 12.7 0.1 2.3 2 0 0 2 2 2 0 CHC2 zinc finger Chordopox_A13L PF05961.11 OPL33437.1 - 0.0019 18.4 0.4 0.0071 16.6 0.4 1.9 1 0 0 1 1 1 1 Chordopoxvirus A13L protein TMEM154 PF15102.6 OPL33437.1 - 0.0023 17.9 0.2 0.0036 17.2 0.2 1.5 1 0 0 1 1 1 1 TMEM154 protein family ABC2_membrane_3 PF12698.7 OPL33437.1 - 0.0064 15.6 1.6 0.0089 15.2 1.6 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein Mucin15 PF15672.5 OPL33437.1 - 0.0096 15.5 6.7 0.0096 15.5 6.7 1.8 1 1 1 2 2 2 1 Cell-membrane associated Mucin15 DUF1035 PF06281.12 OPL33437.1 - 0.012 15.6 3.8 0.023 14.7 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) Mid2 PF04478.12 OPL33437.1 - 0.013 15.4 1.2 0.024 14.5 1.2 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF5305 PF17231.2 OPL33437.1 - 0.021 14.2 0.5 0.032 13.6 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Podoplanin PF05808.11 OPL33437.1 - 0.023 14.8 1.5 0.038 14.1 1.5 1.3 1 0 0 1 1 1 0 Podoplanin DUF2207 PF09972.9 OPL33437.1 - 0.028 13.2 0.0 0.036 12.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) BPD_transp_1 PF00528.22 OPL33437.1 - 0.037 13.8 1.1 0.054 13.2 1.1 1.1 1 0 0 1 1 1 0 Binding-protein-dependent transport system inner membrane component Rax2 PF12768.7 OPL33437.1 - 0.048 13.1 0.2 0.08 12.4 0.2 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity SIT PF15330.6 OPL33437.1 - 0.057 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT OppC_N PF12911.7 OPL33437.1 - 0.06 13.3 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Gypsy PF07253.11 OPL33437.1 - 0.062 11.8 0.0 0.087 11.4 0.0 1.1 1 0 0 1 1 1 0 Gypsy protein Herpes_gE PF02480.16 OPL33437.1 - 0.068 11.9 0.0 0.12 11.1 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E MGC-24 PF05283.11 OPL33437.1 - 0.12 12.8 5.0 0.039 14.4 2.0 1.7 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Syndecan PF01034.20 OPL33437.1 - 0.12 12.3 1.9 0.24 11.4 1.9 1.4 1 0 0 1 1 1 0 Syndecan domain Ly49 PF08391.10 OPL33437.1 - 0.22 11.9 1.4 0.45 10.9 1.4 1.7 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region MAM PF00629.23 OPL33439.1 - 1.6e-05 24.9 0.0 0.0074 16.2 0.0 2.1 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu MAM PF00629.23 OPL33440.1 - 7.6e-11 42.2 4.3 2.1e-10 40.8 0.4 2.1 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu MFS_1 PF07690.16 OPL33441.1 - 1.1e-07 31.1 17.7 1.1e-07 31.1 17.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TLD PF07534.16 OPL33442.1 - 4.5e-13 49.6 0.9 7.6e-13 48.9 0.4 1.7 2 0 0 2 2 2 1 TLD RsgA_GTPase PF03193.16 OPL33442.1 - 0.0063 16.4 0.0 0.59 10.0 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase TYW3 PF02676.14 OPL33442.1 - 0.017 14.5 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase TYW3 MMR_HSR1 PF01926.23 OPL33442.1 - 0.021 14.9 0.0 0.049 13.7 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 OPL33442.1 - 0.025 14.4 0.3 0.064 13.0 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PRK PF00485.18 OPL33442.1 - 0.049 13.4 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AIG1 PF04548.16 OPL33442.1 - 0.2 11.0 0.6 0.43 9.9 0.1 1.7 2 0 0 2 2 2 0 AIG1 family Gtr1_RagA PF04670.12 OPL33442.1 - 0.21 10.9 0.5 1.5 8.1 0.1 2.0 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Cadherin PF00028.17 OPL33445.1 - 1.2e-13 51.3 3.0 0.00073 19.9 0.0 3.6 2 1 0 3 3 3 3 Cadherin domain Mem_trans PF03547.18 OPL33447.1 - 3.6e-07 28.9 1.4 4.7e-07 28.6 1.4 1.2 1 0 0 1 1 1 1 Membrane transport protein FKBP_C PF00254.28 OPL33448.1 - 1.3e-30 105.5 0.0 2e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase LSM PF01423.22 OPL33449.1 - 1.4e-08 34.3 0.1 2.3e-08 33.6 0.1 1.4 1 1 0 1 1 1 1 LSM domain RVT_connect PF06815.13 OPL33449.1 - 0.096 13.0 0.3 8.7 6.7 0.1 2.1 1 1 1 2 2 2 0 Reverse transcriptase connection domain DUF2986 PF11661.8 OPL33449.1 - 6.2 7.4 8.6 0.25 11.9 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) Ribosomal_L30_N PF08079.12 OPL33450.1 - 0.05 13.8 0.5 0.094 13.0 0.5 1.4 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Peptidase_C14 PF00656.22 OPL33451.1 - 3.8e-23 82.7 1.4 4.7e-23 82.4 1.4 1.2 1 0 0 1 1 1 1 Caspase domain Vps4_C PF09336.10 OPL33452.1 - 4.9e-21 74.5 0.0 1.4e-20 73.0 0.1 1.8 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA PF00004.29 OPL33452.1 - 1.4e-19 70.8 0.0 2.2e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 OPL33452.1 - 1.3e-05 24.9 0.0 0.00016 21.4 0.0 2.6 3 0 0 3 3 2 1 AAA+ lid domain AAA_16 PF13191.6 OPL33452.1 - 2e-05 25.1 0.0 0.00015 22.2 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 OPL33452.1 - 3.5e-05 23.8 0.0 7.5e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 OPL33452.1 - 0.00012 22.3 0.0 0.0066 16.7 0.0 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 OPL33452.1 - 0.00014 21.6 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 OPL33452.1 - 0.00015 21.0 0.0 0.00025 20.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 OPL33452.1 - 0.00018 22.0 0.0 0.00033 21.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 OPL33452.1 - 0.00029 20.8 0.0 0.0011 19.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 OPL33452.1 - 0.00033 20.4 0.0 0.00058 19.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 OPL33452.1 - 0.00094 18.9 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 OPL33452.1 - 0.0011 19.3 0.0 0.0026 18.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 OPL33452.1 - 0.0012 18.9 0.0 0.0044 17.0 0.0 2.1 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 OPL33452.1 - 0.01 15.6 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 OPL33452.1 - 0.013 15.8 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 OPL33452.1 - 0.016 14.4 0.0 0.098 11.9 0.0 1.9 2 0 0 2 2 2 0 KAP family P-loop domain MMR_HSR1 PF01926.23 OPL33452.1 - 0.018 15.1 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 OPL33452.1 - 0.028 14.6 0.0 0.05 13.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 OPL33452.1 - 0.042 13.8 0.0 0.14 12.1 0.0 1.9 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_7 PF12775.7 OPL33452.1 - 0.044 13.3 0.0 0.11 12.0 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 OPL33452.1 - 0.046 12.9 0.0 0.076 12.2 0.0 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain MCM PF00493.23 OPL33452.1 - 0.058 12.5 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain ABC_tran PF00005.27 OPL33452.1 - 0.064 13.8 0.0 0.28 11.7 0.0 1.9 2 1 0 2 2 2 0 ABC transporter AAA_25 PF13481.6 OPL33452.1 - 0.083 12.5 0.0 1 8.9 0.0 2.1 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 OPL33452.1 - 0.087 12.2 0.1 2.6 7.3 0.0 2.2 1 1 1 2 2 2 0 KaiC AAA_11 PF13086.6 OPL33452.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.15 OPL33452.1 - 0.13 11.0 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_29 PF13555.6 OPL33452.1 - 0.16 11.7 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 OPL33452.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 OPL33452.1 - 0.17 11.6 0.0 0.37 10.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain Vps4_C PF09336.10 OPL33453.1 - 1.3e-13 50.7 0.3 1.3e-13 50.7 0.3 2.1 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 OPL33453.1 - 8.5e-09 35.1 0.0 1.8e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 OPL33453.1 - 2.9e-08 34.2 0.0 5.8e-08 33.2 0.0 1.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CcdB PF01845.17 OPL33453.1 - 0.052 13.8 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 CcdB protein AIG1 PF04548.16 OPL33455.1 - 3.7e-12 46.0 0.4 6e-12 45.3 0.4 1.3 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 OPL33455.1 - 0.00043 20.3 0.3 0.00067 19.7 0.3 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 OPL33455.1 - 0.00054 19.9 0.0 0.0006 19.8 0.0 1.1 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 OPL33455.1 - 0.0093 16.5 0.5 0.013 16.0 0.4 1.3 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 OPL33455.1 - 0.011 15.5 0.2 0.015 15.0 0.2 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 OPL33455.1 - 0.017 14.6 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 OPL33455.1 - 0.021 15.1 0.1 0.029 14.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 OPL33455.1 - 0.022 14.5 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 OPL33455.1 - 0.025 14.6 0.1 0.035 14.1 0.1 1.3 1 0 0 1 1 1 0 Dynamin family DUF87 PF01935.17 OPL33455.1 - 0.029 14.5 0.1 0.038 14.1 0.1 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain PduV-EutP PF10662.9 OPL33455.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 OPL33455.1 - 0.15 11.4 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family ADAM_spacer1 PF05986.14 OPL33456.1 - 8.1e-05 22.6 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 C1q PF00386.21 OPL33457.1 - 2.1e-22 79.7 0.5 2.6e-22 79.4 0.5 1.1 1 0 0 1 1 1 1 C1q domain zf_CCCH_4 PF18345.1 OPL33457.1 - 0.01 15.9 2.4 0.01 15.9 2.4 1.7 2 0 0 2 2 2 0 Zinc finger domain Torus PF16131.5 OPL33457.1 - 0.014 16.0 0.2 0.034 14.8 0.0 1.6 2 0 0 2 2 2 0 Torus domain zf-CCCH PF00642.24 OPL33457.1 - 0.1 12.5 0.9 0.19 11.7 0.9 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DEAD PF00270.29 OPL33458.1 - 1.3e-47 161.9 0.0 2e-47 161.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 OPL33458.1 - 8.1e-26 90.6 0.0 4.1e-25 88.3 0.0 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 OPL33458.1 - 9.4e-05 22.5 0.0 0.00018 21.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ferritin PF00210.24 OPL33458.1 - 0.011 15.7 0.5 0.019 14.9 0.5 1.4 1 0 0 1 1 1 0 Ferritin-like domain ERCC3_RAD25_C PF16203.5 OPL33458.1 - 0.037 13.2 0.1 0.078 12.2 0.1 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Ig_2 PF13895.6 OPL33459.1 - 6.5e-09 36.0 0.0 0.00029 21.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 OPL33459.1 - 2.6e-07 31.2 0.0 0.00062 20.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 OPL33459.1 - 0.00077 19.5 0.0 0.63 10.1 0.0 2.2 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 OPL33459.1 - 0.0036 17.5 0.0 1.2 9.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 OPL33459.1 - 0.012 15.6 0.0 2.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin I-set domain VirK PF06903.12 OPL33459.1 - 0.015 15.3 0.0 5 7.3 0.0 2.2 2 0 0 2 2 2 0 VirK protein GP70 PF17429.2 OPL33459.1 - 0.058 13.2 1.0 11 5.9 0.1 2.3 2 0 0 2 2 2 0 Gene product 70 PARP PF00644.20 OPL33461.1 - 5.5e-27 94.6 0.5 5.5e-27 94.6 0.5 2.6 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Ig_3 PF13927.6 OPL33462.1 - 1.3e-42 144.2 16.5 1.7e-10 41.3 0.6 5.6 6 0 0 6 6 6 5 Immunoglobulin domain I-set PF07679.16 OPL33462.1 - 1.1e-40 137.6 2.2 3e-08 33.6 0.0 6.1 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL33462.1 - 4.1e-27 94.3 17.6 4.7e-06 26.8 0.7 6.1 6 0 0 6 6 6 5 Immunoglobulin domain ig PF00047.25 OPL33462.1 - 2.7e-26 91.6 11.3 1.6e-06 28.2 0.3 5.5 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 OPL33462.1 - 1.4e-18 67.0 15.1 1.9e-05 24.8 0.1 8.8 5 5 0 5 5 5 4 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL33462.1 - 3.9e-08 32.7 1.6 0.21 11.2 0.0 5.7 6 0 0 6 6 6 2 Immunoglobulin domain Ig_5 PF16681.5 OPL33462.1 - 2.9e-06 27.6 1.6 7.4 7.1 0.0 6.2 6 2 0 6 6 6 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 OPL33462.1 - 4.4e-05 23.7 1.6 12 6.3 0.0 6.1 5 2 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Ig_C17orf99 PF17736.1 OPL33462.1 - 0.00022 21.2 6.5 5.9 7.0 0.0 5.8 6 0 0 6 6 6 1 C17orf99 Ig domain Adeno_E3_CR1 PF02440.15 OPL33462.1 - 0.00068 19.4 0.3 0.00068 19.4 0.3 3.9 4 0 0 4 4 4 1 Adenovirus E3 region protein CR1 Receptor_2B4 PF11465.8 OPL33462.1 - 0.00087 19.5 2.0 8.5 6.6 0.0 4.7 4 1 1 5 5 5 1 Natural killer cell receptor 2B4 PBP-Tp47_c PF14888.6 OPL33462.1 - 0.0074 16.2 0.1 0.021 14.7 0.1 1.8 1 0 0 1 1 1 1 Penicillin-binding protein Tp47 domain C zf-CHC2 PF01807.20 OPL33462.1 - 0.011 15.5 0.1 2.2 8.1 0.0 4.0 5 0 0 5 5 5 0 CHC2 zinc finger AbiH PF14253.6 OPL33464.1 - 0.14 12.0 2.1 0.17 11.7 2.1 1.1 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH LMBR1 PF04791.16 OPL33464.1 - 0.41 9.5 2.4 0.47 9.3 2.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Ribosomal_S15 PF00312.22 OPL33466.1 - 0.041 14.1 1.1 0.041 14.1 1.1 1.8 2 0 0 2 2 2 0 Ribosomal protein S15 IMD PF08397.11 OPL33466.1 - 0.37 10.1 6.9 0.45 9.8 6.9 1.1 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF3287 PF11690.8 OPL33466.1 - 0.49 10.1 4.8 0.9 9.3 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) Prominin PF05478.11 OPL33466.1 - 1.4 6.8 5.2 1.6 6.6 5.2 1.0 1 0 0 1 1 1 0 Prominin SLT PF01464.20 OPL33468.1 - 4.5e-05 23.1 0.0 0.007 16.0 0.0 2.1 2 0 0 2 2 2 2 Transglycosylase SLT domain SH3_2 PF07653.17 OPL33469.1 - 1.6e-33 114.1 1.4 1.4e-09 37.4 0.1 3.1 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 OPL33469.1 - 6.5e-31 105.7 0.3 7.5e-11 41.5 0.0 3.2 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 OPL33469.1 - 7.8e-29 99.3 0.0 7.2e-10 38.6 0.0 3.2 3 0 0 3 3 3 3 Variant SH3 domain MIEAP PF16026.5 OPL33470.1 - 4.3e-33 115.2 0.1 4.3e-33 115.2 0.1 1.6 2 0 0 2 2 2 1 Mitochondria-eating protein F-box-like PF12937.7 OPL33472.1 - 2.3e-10 40.2 1.7 4.2e-10 39.4 1.7 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 OPL33472.1 - 2.3e-08 33.7 3.3 4.1e-08 32.9 3.3 1.5 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.6 OPL33472.1 - 0.0077 16.2 1.7 0.028 14.4 1.7 2.0 1 1 0 1 1 1 1 F-box-like domain F-box_4 PF15966.5 OPL33472.1 - 0.012 15.5 3.3 0.081 12.8 2.1 2.3 1 1 1 2 2 2 0 F-box BIR PF00653.21 OPL33473.1 - 7.6e-31 106.6 1.6 2.2e-15 57.1 0.1 2.1 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 OPL33473.1 - 0.00019 21.5 0.6 0.46 10.5 0.1 2.3 2 1 0 2 2 2 2 C3HC zinc finger-like BIR PF00653.21 OPL33474.1 - 1e-35 122.2 6.9 5e-19 68.7 0.9 2.1 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 OPL33474.1 - 2.1e-06 27.8 2.4 0.003 17.6 0.0 2.2 2 0 0 2 2 2 2 C3HC zinc finger-like Ras PF00071.22 OPL33475.1 - 1.8e-19 69.9 0.6 2.1e-19 69.7 0.6 1.0 1 0 0 1 1 1 1 Ras family DUF4611 PF15387.6 OPL33475.1 - 0.01 16.0 2.3 0.014 15.6 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Beta_propel PF09826.9 OPL33475.1 - 0.016 14.0 0.2 0.017 14.0 0.2 1.0 1 0 0 1 1 1 0 Beta propeller domain BRE1 PF08647.11 OPL33475.1 - 0.017 15.2 0.7 0.02 14.9 0.7 1.2 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase F-box-like PF12937.7 OPL33475.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 F-box-like Atg31 PF09795.9 OPL33475.1 - 0.26 11.3 5.6 0.18 11.8 1.3 1.9 1 1 1 2 2 2 0 Autophagy-related protein 31 Fasciclin PF02469.22 OPL33476.1 - 8.8e-23 80.9 1.2 3.6e-13 49.9 0.1 2.1 2 0 0 2 2 2 2 Fasciclin domain Ig_3 PF13927.6 OPL33477.1 - 2e-30 105.2 0.8 1.8e-13 50.9 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 OPL33477.1 - 1.2e-29 102.2 0.0 7.8e-11 41.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL33477.1 - 5.1e-17 62.0 1.1 3.8e-06 27.2 0.2 4.7 4 1 0 4 4 4 2 Immunoglobulin domain ig PF00047.25 OPL33477.1 - 2.4e-16 59.7 2.3 0.00034 20.7 0.3 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 OPL33477.1 - 1.5e-14 54.1 2.6 7.8e-05 22.8 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL33477.1 - 9e-05 22.0 0.2 0.054 13.1 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain V-set_CD47 PF08204.11 OPL33477.1 - 0.00011 22.2 0.9 0.028 14.4 0.2 3.1 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 OPL33477.1 - 0.002 18.1 1.6 0.031 14.3 0.0 3.0 3 1 0 3 3 3 1 Izumo-like Immunoglobulin domain TSP_1 PF00090.19 OPL33478.1 - 3.1e-42 142.6 49.5 9.4e-13 48.2 6.0 4.1 4 0 0 4 4 4 4 Thrombospondin type 1 domain CxC6 PF18721.1 OPL33478.1 - 0.039 14.2 25.7 0.24 11.7 2.6 4.3 2 1 2 4 4 4 0 CxC6 like cysteine cluster associated with KDZ transposases Fibrinogen_C PF00147.18 OPL33479.1 - 7.9e-65 218.7 9.7 8.9e-65 218.6 9.7 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Helicase_C PF00271.31 OPL33480.1 - 6.9e-10 39.3 0.1 2e-09 37.7 0.0 1.8 1 1 1 2 2 2 1 Helicase conserved C-terminal domain Sgf11 PF08209.11 OPL33480.1 - 0.013 15.0 0.1 0.024 14.2 0.1 1.4 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) PqqD PF05402.12 OPL33481.1 - 0.01 16.1 1.3 1.3 9.4 0.0 2.6 1 1 1 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) DUF1028 PF06267.12 OPL33481.1 - 0.042 13.6 0.1 0.085 12.6 0.1 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF1028) MIEAP PF16026.5 OPL33483.1 - 3.2e-10 40.5 0.0 3.8e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondria-eating protein Tmemb_9 PF05434.11 OPL33483.1 - 0.15 12.0 2.9 0.27 11.1 2.2 1.8 1 1 1 2 2 2 0 TMEM9 FhuF PF06276.12 OPL33483.1 - 0.19 12.1 0.0 0.25 11.7 0.0 1.2 1 0 0 1 1 1 0 Ferric iron reductase FhuF-like transporter fn3 PF00041.21 OPL33484.1 - 0.0032 17.8 0.1 0.075 13.4 0.0 2.5 2 1 0 2 2 2 1 Fibronectin type III domain FAD_binding_1 PF00667.20 OPL33485.1 - 1.7e-19 70.3 0.0 2.5e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 OPL33485.1 - 1.2e-14 54.7 0.0 2.1e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Macro PF01661.21 OPL33486.1 - 1.7e-18 66.8 0.1 2.4e-18 66.3 0.1 1.2 1 0 0 1 1 1 1 Macro domain Macro PF01661.21 OPL33487.1 - 5.2e-11 42.6 0.0 8.4e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Macro domain An_peroxidase PF03098.15 OPL33488.1 - 1.8e-58 198.4 0.0 1.9e-42 145.6 0.0 2.0 1 1 1 2 2 2 2 Animal haem peroxidase Y_phosphatase PF00102.27 OPL33489.1 - 3.6e-21 75.8 0.1 4.2e-21 75.6 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 OPL33489.1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.3 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Peptidase_S76 PF13611.6 OPL33489.1 - 0.045 14.1 0.1 0.065 13.6 0.1 1.3 1 1 0 1 1 1 0 Serine peptidase of plant viral polyprotein, P1 Y_phosphatase PF00102.27 OPL33490.1 - 9.9e-05 22.0 0.3 0.00017 21.2 0.3 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase YfiO PF13525.6 OPL33490.1 - 0.0082 15.9 2.7 0.016 15.0 0.5 1.9 1 1 0 2 2 2 1 Outer membrane lipoprotein TetR_C_9 PF14514.6 OPL33490.1 - 0.073 13.2 0.0 0.08 13.1 0.0 1.1 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Fibrinogen_C PF00147.18 OPL33492.1 - 1.3e-33 116.7 2.4 1.5e-33 116.4 2.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain CABIT PF12736.7 OPL33493.1 - 0.00025 20.4 0.2 0.002 17.5 0.1 2.1 2 0 0 2 2 2 1 Cell-cycle sustaining, positive selection, SAM_2 PF07647.17 OPL33493.1 - 0.00034 20.7 0.1 0.00094 19.2 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 OPL33493.1 - 0.00057 20.3 0.2 0.0012 19.2 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MA3 PF02847.17 OPL33493.1 - 0.071 13.1 0.1 0.18 11.8 0.1 1.6 1 0 0 1 1 1 0 MA3 domain EphA2_TM PF14575.6 OPL33494.1 - 0.015 16.1 0.0 0.016 16.1 0.0 1.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 OPL33494.1 - 0.066 13.1 0.1 0.099 12.5 0.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family SKG6 PF08693.10 OPL33494.1 - 0.75 9.3 5.6 1.2 8.6 5.6 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Sfi1 PF08457.10 OPL33495.1 - 6.9e-11 41.4 114.7 2.3e-05 23.1 25.9 5.4 2 1 3 5 5 5 5 Sfi1 spindle body protein DUF4407 PF14362.6 OPL33496.1 - 0.32 10.3 0.8 0.46 9.8 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COR PF16095.5 OPL33497.1 - 6.1e-14 52.3 2.1 1.6e-13 50.9 2.1 1.7 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 OPL33497.1 - 3e-05 24.2 0.1 0.00012 22.3 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase CARD PF00619.21 OPL33498.1 - 8.1e-24 83.5 4.5 3.8e-13 49.3 0.3 2.4 2 0 0 2 2 2 2 Caspase recruitment domain CARD_2 PF16739.5 OPL33498.1 - 6.3e-18 64.6 1.3 4.9e-09 36.1 0.1 2.3 2 0 0 2 2 2 2 Caspase recruitment domain COR PF16095.5 OPL33499.1 - 1e-14 54.8 1.4 9.6e-14 51.6 0.3 2.5 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain Roc PF08477.13 OPL33499.1 - 3.4e-08 33.7 1.5 1.4e-07 31.7 0.8 2.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MCR_C PF04609.12 OPL33499.1 - 0.021 13.9 0.0 0.037 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C C1q PF00386.21 OPL33500.1 - 1.7e-12 47.6 0.6 2.4e-12 47.2 0.6 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL33500.1 - 0.049 13.5 0.6 0.062 13.2 0.6 1.2 1 0 0 1 1 1 0 BclA C-terminal domain Man-6-P_recep PF02157.15 OPL33501.1 - 1.5e-29 102.8 0.4 1.8e-29 102.6 0.4 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.18 OPL33501.1 - 0.07 13.2 0.0 0.26 11.3 0.0 1.7 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat Sushi PF00084.20 OPL33502.1 - 4.7e-24 84.7 10.9 2.5e-08 34.4 0.1 3.2 2 1 1 3 3 3 3 Sushi repeat (SCR repeat) HRM PF02793.22 OPL33502.1 - 0.00013 22.2 6.4 0.35 11.2 0.3 3.3 2 1 1 3 3 3 2 Hormone receptor domain Gla PF00594.20 OPL33502.1 - 0.0028 17.8 1.6 19 5.5 0.1 3.3 3 0 0 3 3 3 3 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Prenyltrans PF00432.21 OPL33502.1 - 0.017 14.8 0.6 8.7 6.2 0.1 3.1 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat MIEAP PF16026.5 OPL33503.1 - 2.3e-31 109.6 2.2 3.4e-31 109.0 0.1 2.1 2 0 0 2 2 2 1 Mitochondria-eating protein AreA_N PF07573.11 OPL33504.1 - 0.05 14.3 1.2 0.077 13.6 1.2 1.4 1 0 0 1 1 1 0 Nitrogen regulatory protein AreA N terminus Lectin_C PF00059.21 OPL33505.1 - 9.5e-20 71.3 7.3 1.8e-19 70.4 7.3 1.5 1 0 0 1 1 1 1 Lectin C-type domain GH114_assoc PF14741.6 OPL33505.1 - 0.11 12.7 2.3 0.13 12.4 1.5 1.4 1 1 0 1 1 1 0 N-terminal glycosyl-hydrolase-114-associated domain LRR_6 PF13516.6 OPL33507.1 - 2.7e-24 83.1 14.8 0.00016 21.4 0.1 9.4 8 1 1 9 9 9 7 Leucine Rich repeat LRR_1 PF00560.33 OPL33507.1 - 5.4e-10 38.4 3.2 2 9.3 0.0 7.4 7 0 0 7 7 7 2 Leucine Rich Repeat EF-hand_1 PF00036.32 OPL33507.1 - 3.3e-09 35.6 4.0 0.00039 19.8 0.8 3.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 OPL33507.1 - 1.4e-07 31.2 4.1 1.8e-06 27.7 1.3 3.7 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.6 OPL33507.1 - 2.2e-06 27.2 4.3 0.032 14.2 0.1 3.9 3 1 1 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 OPL33507.1 - 5.5e-05 23.5 8.5 0.00096 19.6 2.0 3.9 2 1 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 OPL33507.1 - 0.012 15.1 0.8 0.012 15.1 0.8 3.8 4 0 0 4 4 3 0 EF hand LRR_4 PF12799.7 OPL33507.1 - 0.017 15.6 12.8 0.73 10.3 0.7 5.5 4 3 2 6 6 6 0 Leucine Rich repeats (2 copies) EF-hand_11 PF08976.11 OPL33507.1 - 0.093 13.6 0.1 0.2 12.5 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_4 PF12763.7 OPL33507.1 - 0.11 12.5 0.2 0.4 10.6 0.2 2.0 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand LRR_8 PF13855.6 OPL33507.1 - 0.43 10.4 13.7 17 5.2 0.7 5.7 3 3 1 5 5 5 0 Leucine rich repeat C1q PF00386.21 OPL33508.1 - 4.1e-10 40.0 0.1 8.5e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 C1q domain Spc7 PF08317.11 OPL33508.1 - 0.0011 17.9 0.4 0.0013 17.6 0.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein FemAB PF02388.16 OPL33508.1 - 0.0014 17.6 1.8 0.13 11.2 1.3 2.1 2 0 0 2 2 2 1 FemAB family YkyA PF10368.9 OPL33508.1 - 0.0024 17.5 4.6 0.0024 17.5 4.6 1.4 2 0 0 2 2 2 1 Putative cell-wall binding lipoprotein Apolipoprotein PF01442.18 OPL33508.1 - 0.0078 16.1 0.2 0.012 15.5 0.2 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DASH_Duo1 PF08651.10 OPL33508.1 - 0.015 15.0 0.7 0.26 11.1 0.2 2.6 2 0 0 2 2 2 0 DASH complex subunit Duo1 IMD PF08397.11 OPL33508.1 - 0.019 14.4 0.3 0.028 13.8 0.3 1.4 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF4407 PF14362.6 OPL33508.1 - 0.022 14.1 1.0 0.029 13.7 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Vps51 PF08700.11 OPL33508.1 - 0.03 14.4 3.2 0.054 13.6 2.2 1.9 1 1 1 2 2 2 0 Vps51/Vps67 Baculo_PEP_C PF04513.12 OPL33508.1 - 0.031 14.3 2.4 0.063 13.3 2.1 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HIP1_clath_bdg PF16515.5 OPL33508.1 - 0.034 14.8 2.7 0.058 14.0 2.7 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-K PF11802.8 OPL33508.1 - 0.047 13.3 1.4 0.077 12.6 1.4 1.3 1 0 0 1 1 1 0 Centromere-associated protein K DUF1690 PF07956.11 OPL33508.1 - 0.057 13.8 1.3 0.09 13.2 1.3 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) SKA2 PF16740.5 OPL33508.1 - 0.058 13.2 1.0 0.098 12.4 1.0 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Hormone_1 PF00103.20 OPL33508.1 - 0.059 13.1 0.5 0.13 12.0 0.4 1.5 1 1 0 1 1 1 0 Somatotropin hormone family Mce4_CUP1 PF11887.8 OPL33508.1 - 0.076 12.5 0.5 0.11 11.9 0.5 1.2 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative GAS PF13851.6 OPL33508.1 - 0.078 12.3 5.6 0.33 10.3 4.9 1.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TolA_bind_tri PF16331.5 OPL33508.1 - 0.085 12.9 0.3 0.15 12.1 0.3 1.4 1 0 0 1 1 1 0 TolA binding protein trimerisation Nup54 PF13874.6 OPL33508.1 - 0.099 12.8 0.6 0.16 12.1 0.6 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 WXG100 PF06013.12 OPL33508.1 - 0.1 12.8 0.9 0.38 11.0 0.5 2.0 1 1 1 2 2 2 0 Proteins of 100 residues with WXG UPF0242 PF06785.11 OPL33508.1 - 0.14 12.2 2.6 0.21 11.7 2.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ZapB PF06005.12 OPL33508.1 - 0.29 11.6 3.4 1.6 9.2 3.4 2.1 1 1 0 1 1 1 0 Cell division protein ZapB DUF883 PF05957.13 OPL33508.1 - 0.32 11.6 1.3 0.75 10.4 0.7 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) YabA PF06156.13 OPL33508.1 - 0.36 11.5 2.7 0.53 11.0 1.3 1.9 2 1 0 2 2 1 0 Initiation control protein YabA DUF1664 PF07889.12 OPL33508.1 - 0.37 10.8 2.9 0.95 9.5 2.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 OPL33508.1 - 0.54 10.5 4.4 0.82 9.8 0.8 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family I-set PF07679.16 OPL33509.1 - 3.8e-13 49.3 0.0 5.3e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33509.1 - 4e-09 37.0 0.0 7.1e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 OPL33509.1 - 8.6e-07 29.0 0.0 1.5e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL33509.1 - 5.1e-05 23.5 0.1 0.00017 21.9 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 OPL33509.1 - 0.023 14.9 0.1 0.17 12.1 0.1 2.1 1 1 0 1 1 1 0 Immunoglobulin V-set domain I-set PF07679.16 OPL33510.1 - 1.3e-19 70.1 0.4 2.6e-13 49.8 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33510.1 - 3.7e-19 69.1 0.4 2.1e-14 53.9 0.3 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 OPL33510.1 - 9.3e-12 45.1 0.1 4.2e-09 36.6 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL33510.1 - 2.3e-10 40.5 0.0 6.1e-05 23.1 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 OPL33510.1 - 4.9e-08 33.1 0.3 0.005 17.0 0.0 2.5 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL33510.1 - 0.032 13.8 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Lectin_C PF00059.21 OPL33511.1 - 6.9e-11 42.8 1.2 6.9e-11 42.8 1.2 1.8 1 1 1 2 2 2 1 Lectin C-type domain DUF1664 PF07889.12 OPL33511.1 - 0.015 15.3 1.4 0.025 14.6 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) OSTMP1 PF09777.9 OPL33511.1 - 0.016 14.6 3.1 0.021 14.2 3.1 1.2 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor DUF2829 PF11195.8 OPL33511.1 - 0.17 12.2 3.7 0.17 12.1 2.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2829) Lectin_C PF00059.21 OPL33512.1 - 7e-17 62.1 4.0 7e-17 62.1 4.0 1.9 2 0 0 2 2 2 1 Lectin C-type domain SLR1-BP PF07333.12 OPL33512.1 - 5.4 7.5 12.2 4 8.0 5.4 2.6 2 1 0 2 2 2 0 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP) Roc PF08477.13 OPL33513.1 - 1.3e-09 38.4 0.0 1.7e-06 28.3 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL33513.1 - 0.066 12.8 0.0 0.41 10.2 0.0 2.2 2 0 0 2 2 2 0 Ras family AlbA_2 PF04326.14 OPL33514.1 - 1e-07 32.3 0.5 1e-07 32.3 0.5 2.7 2 1 0 2 2 2 1 Putative DNA-binding domain Sod_Cu PF00080.20 OPL33515.1 - 2.2e-31 108.9 0.0 2.6e-31 108.7 0.0 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DUF4423 PF14394.6 OPL33516.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Death PF00531.22 OPL33517.1 - 2.9e-07 30.5 0.1 0.00037 20.6 0.0 2.7 2 0 0 2 2 2 2 Death domain TIR_2 PF13676.6 OPL33517.1 - 5.5e-05 23.7 0.1 0.0003 21.4 0.0 2.3 3 1 0 3 3 3 1 TIR domain CARD PF00619.21 OPL33517.1 - 0.00045 20.2 1.3 0.012 15.6 0.0 2.7 2 0 0 2 2 2 1 Caspase recruitment domain TIR PF01582.20 OPL33517.1 - 0.00091 19.1 0.1 0.0035 17.1 0.1 2.0 1 0 0 1 1 1 1 TIR domain DUF2852 PF11014.8 OPL33517.1 - 0.0042 17.2 1.3 0.011 15.9 1.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2852) OmpH PF03938.14 OPL33517.1 - 0.0091 16.3 0.6 0.0091 16.3 0.6 2.4 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) CARD_2 PF16739.5 OPL33517.1 - 0.014 15.3 0.3 0.33 11.0 0.1 2.7 2 0 0 2 2 2 0 Caspase recruitment domain DUF3972 PF13118.6 OPL33517.1 - 0.27 11.7 4.7 0.77 10.2 4.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3972) Shugoshin_N PF07558.11 OPL33517.1 - 0.61 10.0 8.1 0.05 13.5 2.5 2.1 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region FlxA PF14282.6 OPL33517.1 - 1.4 8.9 18.2 2.5 8.1 3.0 2.7 2 1 0 2 2 2 0 FlxA-like protein LAGLIDADG_1 PF00961.19 OPL33517.1 - 1.7 9.6 11.0 0.35 11.9 1.6 3.7 3 2 1 4 4 4 0 LAGLIDADG endonuclease zf-RING_2 PF13639.6 OPL33520.1 - 1.5e-07 31.6 10.2 2.8e-07 30.7 10.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 OPL33520.1 - 6.7e-07 29.2 9.5 1.5e-06 28.1 9.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 OPL33520.1 - 0.00011 22.1 8.7 0.00019 21.3 8.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 OPL33520.1 - 0.00013 21.7 9.9 0.00026 20.8 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 OPL33520.1 - 0.016 14.9 3.8 0.032 14.0 2.7 1.9 1 1 1 2 2 2 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 OPL33520.1 - 0.1 12.4 11.2 0.13 12.1 8.9 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 OPL33520.1 - 0.13 12.4 9.4 0.44 10.8 9.4 1.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 OPL33520.1 - 0.37 10.6 12.6 0.11 12.3 9.4 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF1272 PF06906.11 OPL33520.1 - 0.41 10.8 8.4 0.81 9.8 8.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Prok-RING_4 PF14447.6 OPL33520.1 - 0.61 10.0 8.1 1.6 8.7 8.0 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 BIR PF00653.21 OPL33521.1 - 4.1e-34 117.1 7.6 6.8e-19 68.3 1.1 3.0 3 0 0 3 3 3 2 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 OPL33521.1 - 6.9e-13 48.2 6.8 6.9e-13 48.2 6.8 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 OPL33521.1 - 0.00052 19.8 8.2 0.00052 19.8 8.2 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 OPL33521.1 - 0.0072 16.3 6.9 0.0072 16.3 6.9 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 OPL33521.1 - 0.0081 16.5 9.6 0.0081 16.5 9.6 2.8 3 0 0 3 3 3 1 Ring finger domain RNA_pol_N PF01194.17 OPL33521.1 - 0.36 11.2 3.2 6.1 7.2 0.1 3.3 3 0 0 3 3 3 0 RNA polymerases N / 8 kDa subunit Aldo_ket_red PF00248.21 OPL33522.1 - 8.7e-29 100.6 0.0 1.2e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1408 PF07193.11 OPL33522.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1408) Glyco_transf_7N PF13733.6 OPL33524.1 - 0.021 14.5 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 LRAT PF04970.13 OPL33525.1 - 1.5e-34 119.1 0.1 1.9e-34 118.7 0.1 1.2 1 0 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 OPL33525.1 - 0.0013 18.7 0.0 0.0024 17.9 0.0 1.5 1 0 0 1 1 1 1 NlpC/P60 family Peptidase_C97 PF05903.14 OPL33525.1 - 0.054 13.3 0.1 0.11 12.3 0.0 1.6 1 1 1 2 2 2 0 PPPDE putative peptidase domain GSH-S_ATP PF02955.16 OPL33527.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain DcuA_DcuB PF03605.14 OPL33528.1 - 0.11 11.4 0.1 0.11 11.3 0.1 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter PDCD7 PF16021.5 OPL33529.1 - 2.4e-56 191.1 23.3 2.4e-56 191.1 23.3 1.4 1 1 0 1 1 1 1 Programmed cell death protein 7 MMPL PF03176.15 OPL33529.1 - 0.79 8.6 1.4 1.3 7.9 1.4 1.3 1 0 0 1 1 1 0 MMPL family Roc PF08477.13 OPL33531.1 - 8.4e-06 26.0 0.1 1.6e-05 25.1 0.1 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 OPL33531.1 - 0.00049 19.6 0.0 0.0012 18.4 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family DAP3 PF10236.9 OPL33531.1 - 0.00072 18.8 0.0 0.00088 18.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 MMR_HSR1 PF01926.23 OPL33531.1 - 0.00082 19.4 0.0 0.0011 19.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 OPL33531.1 - 0.0012 18.5 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Ras family AAA_22 PF13401.6 OPL33531.1 - 0.0013 19.0 0.0 0.0016 18.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 OPL33531.1 - 0.003 18.1 0.3 0.0039 17.7 0.3 1.3 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 OPL33531.1 - 0.0031 17.9 0.3 0.0038 17.6 0.3 1.3 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 OPL33531.1 - 0.0067 15.9 0.0 0.011 15.2 0.0 1.4 1 1 0 1 1 1 1 Bacterial TniB protein NACHT PF05729.12 OPL33531.1 - 0.0094 15.9 0.1 0.014 15.3 0.1 1.3 1 0 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 OPL33531.1 - 0.016 15.2 0.1 0.019 14.9 0.1 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Septin PF00735.18 OPL33531.1 - 0.018 14.3 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Septin RsgA_GTPase PF03193.16 OPL33531.1 - 0.027 14.4 0.1 0.049 13.5 0.1 1.4 1 1 0 1 1 1 0 RsgA GTPase AAA_14 PF13173.6 OPL33531.1 - 0.038 14.0 0.1 0.051 13.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 OPL33531.1 - 0.038 14.5 0.1 0.048 14.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 OPL33531.1 - 0.043 13.3 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_24 PF13479.6 OPL33531.1 - 0.056 13.2 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 OPL33531.1 - 0.06 12.9 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 OPL33531.1 - 0.073 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_33 PF13671.6 OPL33531.1 - 0.079 13.1 0.1 0.16 12.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 OPL33531.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain SGL PF08450.12 OPL33532.1 - 1.4e-05 24.8 0.1 0.0095 15.5 0.0 3.4 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 OPL33532.1 - 0.00064 19.6 1.3 7.4 6.8 0.0 3.9 3 0 0 3 3 3 2 NHL repeat SBBP PF06739.11 OPL33532.1 - 0.08 13.0 0.6 4 7.5 0.0 2.8 2 0 0 2 2 2 0 Beta-propeller repeat E3_binding PF02817.17 OPL33532.1 - 0.2 12.1 0.0 0.4 11.1 0.0 1.5 1 0 0 1 1 1 0 e3 binding domain DUF1464 PF07318.12 OPL33533.1 - 0.18 10.9 0.0 0.25 10.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) Y_Y_Y PF07495.13 OPL33535.1 - 0.031 14.2 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Y_Y_Y domain BRICHOS PF04089.14 OPL33540.1 - 0.0072 16.5 0.2 0.027 14.7 0.1 1.8 1 1 1 2 2 2 1 BRICHOS domain DUF2206 PF09971.9 OPL33540.1 - 0.03 13.1 0.8 0.037 12.8 0.7 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2206) Fve PF09259.11 OPL33540.1 - 0.08 13.1 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Fungal immunomodulatory protein Fve LRRNT PF01462.18 OPL33542.1 - 6.8e-06 25.6 3.2 1.3e-05 24.7 3.2 1.5 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 OPL33542.1 - 0.00026 20.7 0.1 0.00033 20.3 0.1 1.2 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 OPL33542.1 - 0.0052 17.2 0.4 0.0078 16.6 0.4 1.3 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 OPL33542.1 - 0.16 12.1 0.7 0.26 11.4 0.1 1.7 2 0 0 2 2 2 0 Leucine Rich repeat Peptidase_C14 PF00656.22 OPL33543.1 - 7.2e-32 111.3 0.4 1.2e-31 110.6 0.1 1.5 2 0 0 2 2 2 1 Caspase domain CARD PF00619.21 OPL33543.1 - 2e-18 66.2 0.2 5.2e-18 64.8 0.2 1.8 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 OPL33543.1 - 0.0037 17.2 0.0 0.0086 16.0 0.0 1.6 1 0 0 1 1 1 1 Caspase recruitment domain Peptidase_C1 PF00112.23 OPL33544.1 - 1.2e-62 211.8 7.3 1.7e-62 211.4 7.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 OPL33544.1 - 2.7e-12 46.9 0.2 5.3e-12 46.0 0.2 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Ig_3 PF13927.6 OPL33545.1 - 3.1e-38 130.2 4.4 4.6e-15 56.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 OPL33545.1 - 3.5e-33 113.5 5.3 7.4e-13 48.4 0.8 3.9 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 OPL33545.1 - 4.9e-29 100.3 0.7 2.6e-08 33.9 0.1 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 OPL33545.1 - 5.3e-24 84.4 9.3 2.8e-10 40.4 0.0 4.6 3 2 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 OPL33545.1 - 5.8e-20 71.5 7.9 2e-07 31.1 0.5 3.7 3 1 0 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 OPL33545.1 - 4.4e-09 36.3 0.9 0.0098 15.9 0.1 3.4 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 OPL33545.1 - 0.0041 16.7 0.1 4 7.1 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.5 OPL33545.1 - 0.057 13.5 0.8 27 4.9 0.0 3.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Peptidase_M14 PF00246.24 OPL33546.1 - 1.4e-74 251.5 0.4 1.6e-74 251.3 0.4 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase YfiO PF13525.6 OPL33548.1 - 0.019 14.7 0.3 0.024 14.4 0.3 1.2 1 1 0 1 1 1 0 Outer membrane lipoprotein SmpA_OmlA PF04355.13 OPL33548.1 - 0.093 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 SmpA / OmlA family C1q PF00386.21 OPL33549.1 - 4.2e-05 23.8 0.1 4.2e-05 23.8 0.1 2.8 2 1 0 4 4 4 1 C1q domain SF-assemblin PF06705.11 OPL33549.1 - 0.0059 16.0 13.5 0.0059 16.0 13.5 2.0 1 1 1 2 2 2 1 SF-assemblin/beta giardin Tape_meas_lam_C PF09718.10 OPL33549.1 - 0.023 14.8 2.8 0.095 12.8 0.1 2.9 3 0 0 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Apolipoprotein PF01442.18 OPL33549.1 - 0.29 11.0 12.1 2.7 7.8 10.7 2.2 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 OPL33549.1 - 0.36 11.5 5.5 8.7 7.0 0.1 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) TetR_C_13 PF16925.5 OPL33549.1 - 0.48 10.4 2.8 12 5.8 0.1 2.9 1 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain OmpH PF03938.14 OPL33549.1 - 0.61 10.4 24.9 0.17 12.2 18.1 2.5 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 OPL33549.1 - 0.77 9.1 9.5 1.2 8.5 9.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 OPL33549.1 - 0.78 9.8 10.3 0.55 10.3 1.3 2.7 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Goodbye PF17109.5 OPL33549.1 - 0.8 10.2 7.5 1.6 9.2 0.6 2.8 2 1 0 2 2 2 0 fungal STAND N-terminal Goodbye domain YtxH PF12732.7 OPL33549.1 - 1.8 9.1 6.4 2.6e+02 2.2 6.4 3.3 1 1 0 1 1 1 0 YtxH-like protein GlcNAc-1_reg PF18440.1 OPL33549.1 - 2.2 8.6 6.3 19 5.5 1.0 3.2 2 1 1 3 3 3 0 Putative GlcNAc-1 phosphotransferase regulatory domain Ank_2 PF12796.7 OPL33550.1 - 4e-08 33.7 0.1 4.5e-08 33.6 0.1 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL33550.1 - 5e-07 30.1 0.1 9.8e-07 29.2 0.1 1.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 OPL33550.1 - 2.5e-06 27.6 0.2 4.3e-06 26.9 0.2 1.5 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 OPL33550.1 - 1.8e-05 25.0 0.0 3.7e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 OPL33550.1 - 0.00012 22.2 0.0 0.00023 21.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 OPL33551.1 - 1.2e-10 41.8 0.1 9.1e-07 29.4 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 OPL33551.1 - 7.3e-08 32.5 0.0 0.0024 18.2 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 OPL33551.1 - 5e-07 30.2 0.5 0.0047 17.5 0.1 3.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL33551.1 - 1.6e-06 28.0 0.3 0.0062 16.9 0.0 3.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 OPL33551.1 - 5.3e-06 26.6 1.1 0.00017 21.8 0.2 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DUF4796 PF16044.5 OPL33551.1 - 0.03 13.9 0.1 0.065 12.8 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4796) COR PF16095.5 OPL33552.1 - 4.6e-13 49.4 0.1 8.6e-13 48.5 0.2 1.7 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain MAM PF00629.23 OPL33553.1 - 3.9e-27 95.1 0.4 2.8e-26 92.3 0.1 2.5 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu PBP-Tp47_a PF14889.6 OPL33553.1 - 0.0068 16.1 0.6 0.02 14.5 0.6 1.8 1 0 0 1 1 1 1 Penicillin-binding protein Tp47 domain a EphA2_TM PF14575.6 OPL33553.1 - 0.07 14.0 0.5 34 5.4 0.0 3.0 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Phage_holin_2_1 PF04971.12 OPL33553.1 - 0.17 11.9 0.1 0.4 10.7 0.1 1.6 1 0 0 1 1 1 0 Bacteriophage P21 holin S TTKRSYEDQ PF10212.9 OPL33554.1 - 6.7e-92 309.2 15.5 6.7e-92 309.2 15.5 2.1 2 0 0 2 2 2 1 Predicted coiled-coil domain-containing protein KLRAQ PF10205.9 OPL33554.1 - 4.8e-26 90.9 4.5 4.8e-26 90.9 4.5 3.6 4 1 0 4 4 4 1 Predicted coiled-coil domain-containing protein Tropomyosin_1 PF12718.7 OPL33554.1 - 6.7e-05 23.1 19.6 6.7e-05 23.1 19.6 4.0 3 1 1 4 4 4 1 Tropomyosin like KASH_CCD PF14662.6 OPL33554.1 - 0.038 13.8 36.5 0.034 14.0 19.9 3.5 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH YscO PF07321.12 OPL33554.1 - 0.21 11.5 0.0 0.21 11.5 0.0 5.1 4 1 0 5 5 5 0 Type III secretion protein YscO DHR10 PF18595.1 OPL33554.1 - 0.21 11.6 42.7 0.041 13.9 7.6 4.5 4 1 0 4 4 4 0 Designed helical repeat protein 10 domain TACC_C PF05010.14 OPL33554.1 - 1 9.1 33.8 5.4 6.7 18.5 3.5 2 1 0 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Tropomyosin PF00261.20 OPL33554.1 - 2.1 7.7 36.3 0.3 10.4 29.9 2.6 3 1 0 3 3 3 0 Tropomyosin XhlA PF10779.9 OPL33554.1 - 5 7.4 21.5 0.76 10.0 0.5 4.2 4 1 1 5 5 5 0 Haemolysin XhlA zf-B_box PF00643.24 OPL33555.1 - 6.5e-08 32.6 35.2 6.8e-05 22.9 8.4 2.8 2 0 0 2 2 2 2 B-box zinc finger SGL PF08450.12 OPL33555.1 - 5e-07 29.6 0.3 0.00023 20.8 0.1 2.5 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 OPL33555.1 - 7.8e-05 22.6 1.6 0.00025 21.0 1.6 1.9 1 0 0 1 1 1 1 Beta-propeller repeat NHL PF01436.21 OPL33555.1 - 0.035 14.1 1.5 0.035 14.1 1.5 3.3 3 0 0 3 3 3 0 NHL repeat Glyco_hydro_4C PF11975.8 OPL33555.1 - 0.09 12.8 0.8 0.19 11.8 0.8 1.6 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain HTH_11 PF08279.12 OPL33555.1 - 0.13 12.2 0.3 1.3 9.1 0.1 2.3 2 0 0 2 2 2 0 HTH domain Thioredoxin_10 PF17991.1 OPL33555.1 - 0.2 12.2 1.1 5.3 7.6 0.0 2.8 3 0 0 3 3 3 0 Thioredoxin like C-terminal domain Lectin_N PF03954.14 OPL33555.1 - 0.55 10.0 14.0 0.24 11.2 7.1 2.6 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DLP_helical PF18709.1 OPL33555.1 - 0.57 9.3 18.0 0.25 10.5 7.6 2.2 1 1 1 2 2 2 0 Dynamin-like helical domain Exonuc_VII_L PF02601.15 OPL33555.1 - 1.2 8.7 8.9 1.9 8.0 8.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 OPL33555.1 - 2.2 8.6 19.8 48 4.3 19.8 2.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Baculo_PEP_C PF04513.12 OPL33555.1 - 3.5 7.7 12.9 1.1 9.3 7.0 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 OPL33555.1 - 3.9 6.8 8.2 5.5 6.2 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ChW PF07538.11 OPL33556.1 - 0.16 12.0 0.1 0.31 11.0 0.0 1.5 2 0 0 2 2 2 0 Clostridial hydrophobic W DUF5582 PF17819.1 OPL33557.1 - 3.4e-14 53.5 0.8 5.5e-14 52.8 0.8 1.5 1 1 0 1 1 1 1 Family of unknown function (DUF5582) Toxin_YhaV PF11663.8 OPL33557.1 - 0.0097 16.0 0.9 0.017 15.2 0.8 1.5 1 1 0 1 1 1 1 Toxin with endonuclease activity, of toxin-antitoxin system Bap31_Bap29_C PF18035.1 OPL33557.1 - 0.033 14.2 1.0 0.046 13.7 0.1 1.7 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Dpy-30 PF05186.13 OPL33557.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Dpy-30 motif DUF3486 PF11985.8 OPL33557.1 - 5.1 7.5 7.1 11 6.4 2.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3486) Pkinase_Tyr PF07714.17 OPL33559.1 - 1.6e-16 60.4 0.0 1.7e-16 60.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 OPL33559.1 - 1.9e-12 47.1 0.0 2.2e-12 46.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain ABC1 PF03109.16 OPL33559.1 - 0.035 14.3 0.0 0.045 13.9 0.0 1.2 1 0 0 1 1 1 0 ABC1 family TPR_14 PF13428.6 OPL33560.1 - 0.016 16.0 0.1 15 6.7 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Lectin_C PF00059.21 OPL33561.1 - 3.6e-16 59.8 0.2 3.6e-16 59.8 0.2 2.0 3 0 0 3 3 3 1 Lectin C-type domain adh_short PF00106.25 OPL33564.1 - 1.6e-15 57.1 0.1 2.4e-15 56.5 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 OPL33564.1 - 2.5e-13 50.1 0.1 3.3e-13 49.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase MIF PF01187.18 OPL33565.1 - 2.9e-20 72.7 0.0 3.6e-20 72.4 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) DUF1241 PF06840.11 OPL33565.1 - 0.15 11.7 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) SNF PF00209.18 OPL33567.1 - 1.7e-65 221.7 12.2 4.2e-65 220.4 12.2 1.6 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 OPL33568.1 - 1.6e-65 221.8 4.3 1.8e-65 221.6 4.3 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 OPL33569.1 - 8.3e-26 90.8 5.4 9.4e-26 90.6 5.4 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family CCDC154 PF15450.6 OPL33570.1 - 5e-15 55.1 7.4 6.4e-15 54.7 7.4 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 154 BLOC1_2 PF10046.9 OPL33570.1 - 0.0091 16.3 1.5 0.0091 16.3 1.5 2.1 2 1 0 2 2 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 SKA1 PF07160.12 OPL33570.1 - 0.015 15.1 0.6 0.015 15.1 0.6 3.3 2 2 1 3 3 2 0 Spindle and kinetochore-associated protein 1 DivIC PF04977.15 OPL33570.1 - 0.016 15.0 4.1 0.097 12.5 0.4 2.7 1 1 1 2 2 2 0 Septum formation initiator Ax_dynein_light PF10211.9 OPL33570.1 - 0.025 14.6 4.0 0.025 14.6 4.0 1.8 2 0 0 2 2 2 0 Axonemal dynein light chain PI3K_P85_iSH2 PF16454.5 OPL33570.1 - 0.034 13.7 7.0 0.026 14.1 5.1 1.7 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Mto2_bdg PF12808.7 OPL33570.1 - 0.071 13.4 2.9 0.33 11.3 2.9 2.2 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF2730 PF10805.8 OPL33570.1 - 0.23 11.6 3.1 0.6 10.2 1.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) TMF_TATA_bd PF12325.8 OPL33570.1 - 0.24 11.6 7.9 0.61 10.3 5.2 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Laminin_II PF06009.12 OPL33570.1 - 0.33 11.0 8.9 0.39 10.7 7.1 1.9 1 1 1 2 2 2 0 Laminin Domain II STAT_alpha PF01017.20 OPL33570.1 - 0.37 10.6 9.7 4.9 7.0 0.3 2.6 1 1 0 2 2 2 0 STAT protein, all-alpha domain ABC_tran_CTD PF16326.5 OPL33570.1 - 0.39 11.0 2.9 1.7 9.0 2.4 2.2 1 1 1 2 2 2 0 ABC transporter C-terminal domain Vps53_N PF04100.12 OPL33570.1 - 0.44 9.5 4.7 4.4 6.2 1.0 2.1 1 1 1 2 2 2 0 Vps53-like, N-terminal CENP-F_leu_zip PF10473.9 OPL33570.1 - 0.62 10.1 9.7 2.2 8.3 9.7 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Muted PF14942.6 OPL33570.1 - 0.64 10.4 8.7 0.17 12.2 4.4 2.1 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein FlaC_arch PF05377.11 OPL33570.1 - 0.7 10.3 8.9 3.9 7.9 0.1 3.9 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) HalX PF08663.10 OPL33570.1 - 1.1 9.7 3.3 1.8 8.9 2.0 2.1 2 1 0 2 2 1 0 HalX domain TMPIT PF07851.13 OPL33570.1 - 1.1 8.5 4.4 1.6 7.9 4.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein NPV_P10 PF05531.12 OPL33570.1 - 1.8 9.1 11.1 1.7e+02 2.7 0.2 3.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 OPL33570.1 - 2.6 8.1 7.7 16 5.5 5.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 OPL33570.1 - 3.5 7.7 10.1 24 4.9 10.1 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CENP-H PF05837.12 OPL33570.1 - 3.5 8.1 10.9 8.3 6.9 8.6 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF3086 PF11285.8 OPL33570.1 - 7 5.7 12.8 0.5 9.4 0.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3086) Plk4_PB2 PF18409.1 OPL33571.1 - 0.16 12.7 0.1 0.16 12.7 0.1 3.1 3 2 0 3 3 3 0 Polo-like Kinase 4 Polo Box 2 Ldl_recept_a PF00057.18 OPL33572.1 - 4.3e-77 254.0 175.5 1.4e-12 47.6 9.3 9.7 9 1 1 10 10 9 8 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 OPL33572.1 - 1.7e-31 108.4 8.4 4.6e-09 36.6 0.0 5.5 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 OPL33572.1 - 1.1e-12 48.0 38.5 7.6e-08 32.5 9.6 7.0 6 3 1 7 7 3 3 Coagulation Factor Xa inhibitory site SGL PF08450.12 OPL33572.1 - 8.8e-05 22.2 2.2 0.0091 15.6 0.2 3.0 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 OPL33572.1 - 0.00066 19.5 0.3 0.00066 19.5 0.3 7.2 7 1 0 7 7 7 2 Complement Clr-like EGF-like EGF_3 PF12947.7 OPL33572.1 - 0.0033 17.6 8.4 0.0033 17.6 8.4 10.1 10 2 1 11 11 4 3 EGF domain MLANA PF14991.6 OPL33572.1 - 0.026 14.8 0.0 0.06 13.6 0.0 1.6 1 0 0 1 1 1 0 Protein melan-A Arylesterase PF01731.20 OPL33572.1 - 0.035 14.3 0.1 0.86 9.9 0.0 2.8 3 0 0 3 3 3 0 Arylesterase SKG6 PF08693.10 OPL33572.1 - 0.046 13.1 2.4 0.098 12.1 2.4 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TMEM132D_C PF15706.5 OPL33572.1 - 0.076 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF5050 PF16472.5 OPL33572.1 - 0.11 11.7 0.2 0.21 10.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) Syndecan PF01034.20 OPL33572.1 - 0.21 11.5 0.2 0.39 10.7 0.2 1.4 1 0 0 1 1 1 0 Syndecan domain Ephrin_rec_like PF07699.13 OPL33573.1 - 2.3e-12 46.5 18.7 6.7e-12 45.0 11.7 2.4 1 1 1 2 2 2 2 Putative ephrin-receptor like NCD3G PF07562.14 OPL33573.1 - 0.0028 17.6 1.2 0.0028 17.6 1.2 2.4 1 1 2 3 3 3 2 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 OPL33573.1 - 0.055 13.9 0.3 0.055 13.9 0.3 2.6 1 1 1 2 2 2 0 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 OPL33574.1 - 1.1e-12 47.5 5.4 1.1e-12 47.5 5.4 3.7 2 1 1 3 3 3 2 Putative ephrin-receptor like TSP_1 PF00090.19 OPL33574.1 - 8e-11 42.0 8.2 8e-11 42.0 8.2 3.8 4 0 0 4 4 4 2 Thrombospondin type 1 domain VWA PF00092.28 OPL33575.1 - 2.3e-06 28.0 0.0 3.1e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain LRAT PF04970.13 OPL33576.1 - 2e-07 31.3 0.1 4.2e-07 30.3 0.1 1.6 1 0 0 1 1 1 1 Lecithin retinol acyltransferase DUF5305 PF17231.2 OPL33577.1 - 0.065 12.6 0.0 0.094 12.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) EphA2_TM PF14575.6 OPL33577.1 - 0.079 13.8 0.0 0.15 13.0 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5385 PF17359.2 OPL33578.1 - 0.002 17.8 0.5 0.0035 16.9 0.5 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5385) TMEM154 PF15102.6 OPL33578.1 - 0.0022 17.9 0.3 0.0033 17.3 0.3 1.3 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 OPL33578.1 - 0.0032 18.3 0.0 0.0095 16.8 0.0 1.7 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 OPL33578.1 - 0.0046 17.2 0.0 0.0087 16.3 0.0 1.4 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Sigma_reg_N PF13800.6 OPL33578.1 - 0.013 15.7 0.1 0.12 12.6 0.1 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal SIT PF15330.6 OPL33578.1 - 0.013 15.9 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT EGF PF00008.27 OPL33578.1 - 0.016 15.5 0.8 0.016 15.5 0.8 1.6 2 0 0 2 2 1 0 EGF-like domain SID-1_RNA_chan PF13965.6 OPL33578.1 - 0.02 13.4 0.0 0.028 12.8 0.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FeoB_associated PF12669.7 OPL33578.1 - 0.023 15.1 0.9 0.059 13.8 0.9 1.7 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein EGF_2 PF07974.13 OPL33578.1 - 0.028 14.8 0.7 0.067 13.6 0.7 1.7 1 1 0 1 1 1 0 EGF-like domain ECSCR PF15820.5 OPL33578.1 - 0.032 14.0 0.1 0.057 13.2 0.1 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator 7TM_GPCR_Sru PF10322.9 OPL33578.1 - 0.045 13.1 0.2 0.045 13.1 0.2 1.3 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru Herpes_gE PF02480.16 OPL33578.1 - 0.055 12.2 0.3 0.055 12.2 0.3 2.0 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E DUF3328 PF11807.8 OPL33578.1 - 0.063 13.0 0.7 3.6 7.3 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3328) DUF4446 PF14584.6 OPL33578.1 - 0.068 13.2 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) PRA1 PF03208.19 OPL33578.1 - 0.081 12.5 0.0 4.4 6.9 0.0 2.1 2 0 0 2 2 2 0 PRA1 family protein Cadherin_C_2 PF16492.5 OPL33578.1 - 0.082 13.7 0.1 2.5 8.9 0.0 2.1 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Laminin_EGF PF00053.24 OPL33578.1 - 0.094 12.9 1.7 0.2 11.8 1.7 1.6 1 1 0 1 1 1 0 Laminin EGF domain MRAP PF15183.6 OPL33578.1 - 0.16 11.9 0.1 0.89 9.5 0.0 1.9 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family Stevor PF17410.2 OPL33578.1 - 1.9 8.0 8.8 0.43 10.1 4.8 1.8 1 1 1 2 2 2 0 Subtelomeric Variable Open Reading frame Glyco_transf_92 PF01697.27 OPL33579.1 - 2.1e-16 60.4 1.0 2.9e-16 59.9 1.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase family 92 DUF2407_C PF13373.6 OPL33580.1 - 0.065 13.4 1.3 2.7 8.2 1.2 2.4 1 1 0 1 1 1 0 DUF2407 C-terminal domain DUF1609 PF07753.11 OPL33580.1 - 0.089 12.3 0.0 0.26 10.8 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1609) RE_AlwI PF09491.10 OPL33580.1 - 0.4 9.4 9.6 0.39 9.4 5.6 2.3 1 1 1 2 2 2 0 AlwI restriction endonuclease DUF1917 PF08939.10 OPL33582.1 - 1.5e-16 61.1 1.1 5.1e-15 56.1 0.0 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF1917) VOMI PF03762.17 OPL33583.1 - 3.5e-34 118.4 0.5 3.8e-34 118.3 0.5 1.0 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) Toprim_C_rpt PF13368.6 OPL33583.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat VOMI PF03762.17 OPL33584.1 - 1.6e-46 158.5 0.7 2.4e-46 158.0 0.7 1.2 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) BIR PF00653.21 OPL33585.1 - 3.9e-11 43.4 2.3 3.9e-11 43.4 2.3 2.4 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain Glyco_hydro_2_C PF02836.17 OPL33586.1 - 0.076 12.1 1.1 0.085 11.9 1.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain fn3 PF00041.21 OPL33587.1 - 1.8e-13 50.6 0.3 9.6e-13 48.3 0.1 2.1 2 0 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 OPL33587.1 - 0.039 14.5 0.7 0.097 13.2 0.7 1.8 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain DUF3169 PF11368.8 OPL33587.1 - 0.12 11.8 0.2 0.23 10.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Macro PF01661.21 OPL33588.1 - 4.5e-51 171.9 3.2 1.1e-29 102.9 0.3 3.6 3 0 0 3 3 3 2 Macro domain PARP PF00644.20 OPL33588.1 - 3.1e-08 33.4 7.9 1e-07 31.7 2.4 3.7 2 2 1 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain SLS PF14611.6 OPL33588.1 - 0.00028 20.8 5.6 0.57 10.0 0.1 3.8 3 1 1 4 4 4 2 Mitochondrial inner-membrane-bound regulator Cas_APE2256 PF09651.10 OPL33588.1 - 0.1 12.5 0.1 1.4 8.9 0.0 2.9 2 1 1 3 3 3 0 CRISPR-associated protein (Cas_APE2256) MIS13 PF08202.11 OPL33588.1 - 0.69 9.2 9.2 0.021 14.1 0.8 2.5 3 0 0 3 3 3 0 Mis12-Mtw1 protein family RRM_1 PF00076.22 OPL33589.1 - 0.025 14.4 0.0 0.054 13.3 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 OPL33591.1 - 1.2e-25 90.0 0.0 1.4e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL33591.1 - 8.3e-14 51.8 0.0 9.3e-14 51.7 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 OPL33591.1 - 2e-05 24.1 0.0 2.1e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 OPL33591.1 - 0.098 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 OPL33591.1 - 0.11 11.9 0.0 0.12 11.8 0.0 1.0 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Y_phosphatase PF00102.27 OPL33592.1 - 5.5e-78 261.8 3.0 1.3e-56 191.9 0.4 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 OPL33592.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.20 OPL33592.1 - 0.02 14.7 0.2 0.051 13.4 0.0 1.9 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain p450 PF00067.22 OPL33593.1 - 8.1e-30 104.0 0.4 1.8e-28 99.5 0.1 2.1 2 0 0 2 2 2 2 Cytochrome P450 Dimerisation PF08100.11 OPL33595.1 - 0.18 11.8 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain WWE PF02825.20 OPL33596.1 - 4e-11 43.3 1.5 4e-11 43.3 1.5 2.0 2 0 0 2 2 2 1 WWE domain MIB_HERC2 PF06701.13 OPL33596.1 - 2.3e-09 37.4 4.4 5.9e-09 36.1 4.4 1.7 1 0 0 1 1 1 1 Mib_herc2 ADAM_CR_2 PF17771.1 OPL33598.1 - 8.3e-16 58.3 8.2 8.3e-16 58.3 8.2 2.9 4 0 0 4 4 4 1 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 OPL33598.1 - 1.4e-08 35.2 0.3 1.4e-08 35.2 0.3 2.4 3 0 0 3 3 3 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 OPL33598.1 - 4.1e-06 27.3 0.2 1.1e-05 26.0 0.1 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 OPL33598.1 - 7.5e-06 26.0 0.3 1.8e-05 24.7 0.3 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 OPL33598.1 - 0.0001 22.0 0.4 0.0001 22.0 0.4 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 OPL33598.1 - 0.00014 21.8 0.0 0.00029 20.8 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease YjbE PF11106.8 OPL33598.1 - 0.059 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Exopolysaccharide production protein YjbE CSM2 PF16834.5 OPL33599.1 - 0.029 14.0 0.5 0.043 13.4 0.5 1.2 1 0 0 1 1 1 0 Shu complex component Csm2, DNA-binding YpmT PF17431.2 OPL33599.1 - 0.086 12.9 0.0 2.3 8.3 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized YmpT-like I-set PF07679.16 OPL33600.1 - 0.086 12.9 0.1 0.19 11.8 0.0 1.6 2 0 0 2 2 2 0 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33601.1 - 2.4e-22 79.3 6.8 1.8e-09 38.1 0.2 3.4 2 1 1 3 3 3 3 Immunoglobulin domain I-set PF07679.16 OPL33601.1 - 1.1e-17 63.9 2.2 2.2e-06 27.6 0.0 4.1 2 1 1 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 OPL33601.1 - 1.7e-17 63.4 2.3 4.1e-06 26.9 0.2 4.0 2 1 1 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 OPL33601.1 - 1e-16 61.0 10.5 1.1e-09 38.5 0.1 3.5 2 2 1 3 3 3 3 Immunoglobulin domain V-set PF07686.17 OPL33601.1 - 2.8e-13 50.0 7.8 2.8e-07 30.7 0.8 4.5 3 2 1 4 4 4 3 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL33601.1 - 1.4e-05 24.6 1.0 0.043 13.4 0.0 3.6 4 0 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 OPL33601.1 - 0.054 13.6 0.4 0.41 10.7 0.2 2.2 1 1 1 2 2 2 0 CD80-like C2-set immunoglobulin domain C2-set PF05790.15 OPL33601.1 - 0.071 13.3 0.0 13 6.0 0.0 2.8 2 0 0 2 2 2 0 Immunoglobulin C2-set domain UL141 PF16758.5 OPL33601.1 - 0.14 11.8 0.4 8 6.1 0.0 3.1 3 1 1 4 4 4 0 Herpes-like virus membrane glycoprotein UL141 LptC PF06835.13 OPL33602.1 - 0.048 13.2 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide-assembly, LptC-related HEPN_DZIP3 PF18738.1 OPL33603.1 - 0.0011 18.8 0.6 0.0017 18.1 0.1 1.6 2 0 0 2 2 2 1 DZIP3/ hRUL138-like HEPN Borrelia_REV PF03978.13 OPL33603.1 - 0.0054 16.7 0.9 0.0065 16.4 0.9 1.2 1 0 0 1 1 1 1 Borrelia burgdorferi REV protein RFC1 PF08519.12 OPL33603.1 - 0.077 13.2 0.4 0.12 12.6 0.2 1.4 1 1 0 1 1 1 0 Replication factor RFC1 C terminal domain Lipoprotein_20 PF13942.6 OPL33603.1 - 0.082 12.8 1.6 0.089 12.7 0.5 1.5 2 0 0 2 2 2 0 YfhG lipoprotein DUF1655 PF07868.11 OPL33603.1 - 0.083 13.0 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1655) zf-HC5HC2H_2 PF13832.6 OPL33604.1 - 2.9e-32 111.1 9.6 2.9e-32 111.1 9.6 2.1 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 OPL33604.1 - 5.2e-27 93.9 6.4 5.2e-27 93.9 6.4 3.0 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 OPL33604.1 - 1.3e-12 47.0 7.0 1.3e-12 47.0 7.0 4.1 5 0 0 5 5 5 1 PHD-finger PHD PF00628.29 OPL33604.1 - 3.3e-09 36.5 13.3 3.3e-09 36.5 13.3 3.6 3 2 1 4 4 4 2 PHD-finger zf-PHD-like PF15446.6 OPL33604.1 - 0.0046 16.6 9.3 0.0046 16.6 9.3 3.1 2 2 0 2 2 2 1 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 OPL33604.1 - 0.0061 16.4 9.8 0.0061 16.4 9.8 3.8 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 OPL33604.1 - 2.7 8.4 32.1 1.3 9.4 4.8 3.9 3 1 0 3 3 3 0 C1 domain baeRF_family7 PF18849.1 OPL33605.1 - 0.073 13.3 0.1 0.16 12.2 0.1 1.7 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 7 DUF3929 PF13066.6 OPL33605.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3929) ZZ PF00569.17 OPL33606.1 - 1.3e-09 37.7 9.5 3.2e-09 36.5 9.5 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type SSF PF00474.17 OPL33607.1 - 1e-12 47.7 5.5 1.2e-12 47.5 5.5 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family Bacteriocin_IIc PF10439.9 OPL33607.1 - 0.064 13.4 0.5 0.12 12.5 0.5 1.5 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide DUF2613 PF11021.8 OPL33607.1 - 0.22 11.6 0.1 0.22 11.6 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) Na_K-ATPase PF00287.18 OPL33607.1 - 0.22 10.6 2.3 0.32 10.1 0.1 2.0 2 0 0 2 2 2 0 Sodium / potassium ATPase beta chain ABC2_membrane_5 PF13346.6 OPL33607.1 - 4.1 6.9 16.2 51 3.3 16.3 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein TNFR_c6 PF00020.18 OPL33609.1 - 0.029 14.8 12.3 0.029 14.8 12.3 4.4 4 0 0 4 4 4 0 TNFR/NGFR cysteine-rich region HSDR_N PF04313.14 OPL33612.1 - 0.0011 18.9 0.2 0.0017 18.3 0.2 1.2 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) Laminin_I PF06008.14 OPL33612.1 - 0.032 13.9 6.2 1.4 8.5 6.2 2.4 1 1 0 1 1 1 0 Laminin Domain I YtxH PF12732.7 OPL33612.1 - 0.046 14.3 5.8 1.9 9.1 0.1 3.1 3 1 0 3 3 3 0 YtxH-like protein SelB-wing_2 PF09106.11 OPL33612.1 - 0.15 12.3 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 Elongation factor SelB, winged helix BSD PF03909.17 OPL33612.1 - 0.2 11.7 1.7 21 5.2 0.3 3.3 2 1 1 3 3 3 0 BSD domain DDE_Tnp_IS66 PF03050.14 OPL33612.1 - 0.21 11.0 0.9 1 8.7 0.0 2.0 2 0 0 2 2 2 0 Transposase IS66 family hDGE_amylase PF14701.6 OPL33612.1 - 0.41 9.7 3.0 0.52 9.3 3.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain PBD PF00786.28 OPL33612.1 - 1.6 9.2 0.0 1.6 9.2 0.0 2.8 4 0 0 4 4 4 0 P21-Rho-binding domain DUF1664 PF07889.12 OPL33612.1 - 4.8 7.2 12.2 2.3 8.3 1.7 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Orthopox_F14 PF06076.12 OPL33612.1 - 5.1 7.4 10.2 3.6 7.9 0.3 3.8 2 2 2 4 4 4 0 Orthopoxvirus F14 protein EGF PF00008.27 OPL33613.1 - 0.00065 20.0 2.1 0.00065 20.0 2.1 1.8 2 0 0 2 2 2 1 EGF-like domain Laminin_EGF PF00053.24 OPL33613.1 - 0.0029 17.7 2.0 0.0068 16.5 2.0 1.6 1 0 0 1 1 1 1 Laminin EGF domain EGF_2 PF07974.13 OPL33613.1 - 0.011 16.1 1.9 0.028 14.8 1.9 1.7 1 1 0 1 1 1 0 EGF-like domain Asp_decarbox PF02261.16 OPL33613.1 - 0.21 11.6 0.0 0.29 11.1 0.0 1.2 1 0 0 1 1 1 0 Aspartate decarboxylase HEPN_DZIP3 PF18738.1 OPL33614.1 - 3.1e-13 49.7 4.3 2e-07 30.8 3.0 3.2 2 1 0 2 2 2 2 DZIP3/ hRUL138-like HEPN I-set PF07679.16 OPL33615.1 - 1.4e-08 34.6 0.0 2.1e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33615.1 - 1.3e-06 28.9 0.0 2.1e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 OPL33615.1 - 2.2e-05 24.6 0.1 3.7e-05 23.8 0.1 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 OPL33615.1 - 0.0037 17.5 0.0 0.0062 16.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 OPL33615.1 - 0.0097 16.1 0.1 0.18 12.0 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ctr PF04145.15 OPL33616.1 - 0.051 14.2 0.3 0.079 13.6 0.3 1.3 1 0 0 1 1 1 0 Ctr copper transporter family ThrE PF06738.12 OPL33616.1 - 0.099 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Putative threonine/serine exporter TENA_THI-4 PF03070.16 OPL33617.1 - 0.0022 17.8 0.3 0.0034 17.2 0.3 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family UCH PF00443.29 OPL33617.1 - 0.017 14.6 1.6 0.021 14.3 1.6 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PP2C_C PF07830.13 OPL33617.1 - 1.1 9.8 4.0 1 9.9 1.6 1.9 1 1 1 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain Tetraspanin PF00335.20 OPL33619.1 - 2e-30 106.2 12.7 3.4e-29 102.2 0.9 2.0 1 1 1 2 2 2 2 Tetraspanin family DpnI PF06044.12 OPL33619.1 - 0.13 11.9 1.4 0.19 11.4 1.4 1.2 1 0 0 1 1 1 0 Dam-replacing family Claudin_2 PF13903.6 OPL33619.1 - 0.17 11.6 1.4 0.52 10.0 0.0 2.0 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction LysE PF01810.18 OPL33619.1 - 0.3 10.5 7.1 0.083 12.3 2.7 1.9 2 0 0 2 2 2 0 LysE type translocator TMEM238 PF15125.6 OPL33619.1 - 3.8 7.8 10.8 0.17 12.1 4.7 1.8 2 0 0 2 2 2 0 TMEM238 protein family DUF2614 PF11023.8 OPL33619.1 - 9.1 6.4 6.7 3.8 7.6 3.9 1.7 2 0 0 2 2 2 0 Zinc-ribbon containing domain Arf PF00025.21 OPL33620.1 - 2.3e-42 144.4 0.0 3.4e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 OPL33620.1 - 8.6e-17 61.2 0.0 1.4e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 OPL33620.1 - 1.9e-15 57.1 0.0 3e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 OPL33620.1 - 1.5e-08 34.3 0.0 1.9e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 OPL33620.1 - 1.4e-07 31.2 0.0 1.9e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 OPL33620.1 - 2e-07 30.5 0.1 0.00012 21.4 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 OPL33620.1 - 2e-05 24.6 0.0 3.8e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ApeC PF16977.5 OPL33621.1 - 3.9e-63 213.1 8.6 4.7e-63 212.8 8.6 1.1 1 0 0 1 1 1 1 C-terminal domain of apextrin ApeC PF16977.5 OPL33622.1 - 3e-28 99.2 7.4 3.4e-21 76.1 1.4 2.0 1 1 1 2 2 2 2 C-terminal domain of apextrin LRR_8 PF13855.6 OPL33623.1 - 1.1e-10 41.1 5.9 7e-06 25.7 2.4 2.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 OPL33623.1 - 2.3e-06 27.8 2.0 0.0053 17.1 0.2 2.8 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 OPL33623.1 - 0.11 13.1 2.0 84 4.3 0.1 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat DUF1563 PF07599.11 OPL33623.1 - 0.14 12.3 0.9 0.4 10.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1563) MFS_1 PF07690.16 OPL33624.1 - 0.006 15.5 0.5 6.3 5.6 0.0 2.8 1 1 2 3 3 3 3 Major Facilitator Superfamily MIB_HERC2 PF06701.13 OPL33625.1 - 1.4e-21 76.5 14.0 1.7e-12 47.4 3.4 3.1 2 0 0 2 2 2 2 Mib_herc2 WWE PF02825.20 OPL33625.1 - 1.4e-12 48.0 1.4 5.5e-12 46.1 1.4 2.2 1 0 0 1 1 1 1 WWE domain VWA_2 PF13519.6 OPL33625.1 - 3.5e-09 37.3 0.0 1.2e-08 35.6 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 OPL33625.1 - 4.4e-09 36.8 3.7 5.5e-09 36.5 0.0 2.9 3 1 0 3 3 3 1 von Willebrand factor type A domain DUF4314 PF14192.6 OPL33625.1 - 0.044 13.7 4.2 2.7 8.0 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4314) SH3_15 PF18346.1 OPL33625.1 - 0.066 13.6 4.1 4.4 7.7 4.1 2.9 1 1 0 1 1 1 0 Mind bomb SH3 repeat domain pXO2-34 PF17362.2 OPL33625.1 - 0.12 12.3 2.7 3 7.8 0.3 2.9 3 0 0 3 3 3 0 Family of unknown function Dopey_N PF04118.14 OPL33626.1 - 0.042 13.0 1.8 0.27 10.3 1.8 1.8 1 1 0 1 1 1 0 Dopey, N-terminal DUF1664 PF07889.12 OPL33626.1 - 0.045 13.8 0.3 0.047 13.7 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sema PF01403.19 OPL33627.1 - 2.9e-21 75.8 0.0 3.2e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 Sema domain COR PF16095.5 OPL33629.1 - 4.3e-17 62.6 0.5 1.2e-16 61.2 0.5 1.8 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 OPL33629.1 - 2.8e-11 43.7 0.1 0.00018 21.7 0.0 3.4 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL33629.1 - 3.9e-05 23.3 1.0 0.22 11.1 0.0 3.5 2 1 1 3 3 3 2 Ras family FRD2 PF03197.13 OPL33629.1 - 0.011 16.0 0.1 0.058 13.7 0.1 2.3 1 0 0 1 1 1 0 Bacteriophage FRD2 protein MMR_HSR1 PF01926.23 OPL33629.1 - 0.022 14.8 0.8 2.1 8.4 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase DAPG_hydrolase PF18089.1 OPL33630.1 - 0.012 15.1 0.4 0.021 14.3 0.1 1.5 2 0 0 2 2 2 0 DAPG hydrolase PhiG domain Sugar_tr PF00083.24 OPL33632.1 - 1.5e-28 99.9 12.2 1.9e-28 99.5 12.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 OPL33632.1 - 1.5e-18 66.9 25.9 7.3e-11 41.6 2.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TIMP PF00965.17 OPL33633.1 - 5e-10 39.5 0.0 6.2e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase VP40 PF07447.12 OPL33633.1 - 0.086 11.9 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Matrix protein VP40 AIG1 PF04548.16 OPL33634.1 - 1.9e-55 187.5 0.0 4.3e-55 186.3 0.0 1.7 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 OPL33634.1 - 2.2e-09 37.4 0.0 6.3e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 OPL33634.1 - 0.00022 20.8 0.0 0.00052 19.6 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 OPL33634.1 - 0.00042 20.2 0.1 0.0014 18.6 0.1 1.9 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 OPL33634.1 - 0.0029 18.1 0.0 0.0029 18.1 0.0 2.6 2 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 OPL33634.1 - 0.11 12.8 0.1 0.41 10.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 OPL33634.1 - 2.2 8.8 7.5 2 9.0 0.1 3.5 3 1 0 3 3 3 0 AAA domain AAA_33 PF13671.6 OPL33634.1 - 2.5 8.3 5.3 27 4.9 0.0 3.9 3 1 0 4 4 4 0 AAA domain V-set PF07686.17 OPL33635.1 - 1.5e-06 28.3 2.2 0.011 15.9 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 OPL33635.1 - 0.021 15.0 2.9 1.3 9.2 0.2 2.7 2 1 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 OPL33636.1 - 7.1e-39 131.8 3.5 1.8e-10 40.7 0.0 4.5 4 1 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33636.1 - 2.8e-38 130.4 7.5 4.8e-12 46.3 0.2 4.2 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 OPL33636.1 - 1.1e-31 109.0 5.2 2.1e-07 31.2 0.1 4.2 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 OPL33636.1 - 1.5e-25 89.2 8.0 8.1e-09 35.5 0.3 5.0 4 1 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 OPL33636.1 - 3.9e-14 52.7 13.6 0.00044 20.4 0.3 7.3 4 4 2 6 6 6 4 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL33636.1 - 4.2e-09 35.8 0.1 0.24 11.0 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain Ig_5 PF16681.5 OPL33636.1 - 2e-06 28.1 6.4 0.055 13.9 0.1 4.9 5 2 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Receptor_2B4 PF11465.8 OPL33636.1 - 3.3e-06 27.3 1.1 0.19 12.0 0.0 4.1 4 0 0 4 4 4 2 Natural killer cell receptor 2B4 Izumo-Ig PF16706.5 OPL33636.1 - 2.6e-05 24.2 2.1 7.1 6.8 0.1 4.7 5 1 0 5 5 5 3 Izumo-like Immunoglobulin domain Lep_receptor_Ig PF06328.11 OPL33636.1 - 4.3e-05 23.4 4.1 0.13 12.2 0.0 4.0 4 0 0 4 4 4 2 Ig-like C2-type domain Ig_4 PF16680.5 OPL33636.1 - 0.00018 21.7 4.3 0.075 13.3 0.2 5.1 4 3 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 OPL33636.1 - 0.0029 17.9 8.5 0.14 12.6 0.2 4.3 4 3 0 4 4 4 2 Immunoglobulin C1-set domain V-set_CD47 PF08204.11 OPL33636.1 - 0.0039 17.2 16.2 0.23 11.4 0.6 5.3 2 1 2 4 4 4 2 CD47 immunoglobulin-like domain I-set PF07679.16 OPL33637.1 - 7.7e-33 112.4 0.3 8.2e-12 45.0 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33637.1 - 4.6e-30 104.0 0.8 1.6e-10 41.5 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 OPL33637.1 - 2e-18 66.5 2.9 3.1e-07 30.6 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 OPL33637.1 - 5.3e-15 55.4 0.6 2e-06 27.9 0.0 4.0 3 2 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 OPL33637.1 - 1.8e-10 41.0 8.3 3.1e-05 24.1 0.2 4.4 3 2 0 3 3 3 3 Immunoglobulin V-set domain Ig_5 PF16681.5 OPL33637.1 - 0.00041 20.7 0.5 4 7.9 0.2 4.3 3 2 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 OPL33637.1 - 0.0037 17.3 0.0 4 7.6 0.0 2.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 OPL33637.1 - 0.0041 16.6 0.1 2.9 7.5 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain Ig_C17orf99 PF17736.1 OPL33637.1 - 0.092 12.8 0.0 1.8 8.6 0.0 2.5 2 0 0 2 2 2 0 C17orf99 Ig domain Ig_4 PF16680.5 OPL33637.1 - 0.097 12.9 5.2 12 6.2 0.2 4.1 3 3 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.8 OPL33637.1 - 0.11 12.8 0.0 1.6 9.0 0.0 2.4 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 V-set_CD47 PF08204.11 OPL33637.1 - 0.12 12.4 3.7 0.7 9.9 0.1 3.2 3 1 0 3 3 3 0 CD47 immunoglobulin-like domain C2 PF00168.30 OPL33638.1 - 6.8e-16 58.4 0.0 3.1e-05 24.2 0.0 3.3 3 0 0 3 3 3 3 C2 domain Ion_trans PF00520.31 OPL33640.1 - 0.0051 16.1 4.9 0.0076 15.5 4.9 1.3 1 0 0 1 1 1 1 Ion transport protein 7TM_GPCR_Srh PF10318.9 OPL33640.1 - 0.81 8.7 6.9 0.036 13.1 1.3 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh Ion_trans_2 PF07885.16 OPL33641.1 - 5e-32 109.7 12.1 7.6e-16 57.8 4.3 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 OPL33641.1 - 2.4e-07 30.2 2.0 0.02 14.1 0.0 2.2 1 1 1 2 2 2 2 Ion transport protein Tlr3_TMD PF17968.1 OPL33641.1 - 0.1 12.8 0.4 0.1 12.8 0.4 2.3 2 0 0 2 2 2 0 Toll-like receptor 3 trans-membrane domain Ig_3 PF13927.6 OPL33642.1 - 1.4e-08 35.2 5.6 9.8e-05 22.9 2.9 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 OPL33642.1 - 5.1e-08 33.1 3.1 7.3e-05 23.0 0.6 2.6 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 OPL33642.1 - 5.5e-07 29.6 2.2 0.0041 17.1 1.2 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain ig PF00047.25 OPL33642.1 - 7e-05 22.9 0.6 0.12 12.6 0.2 2.5 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 OPL33642.1 - 9.3e-05 22.4 0.8 0.04 14.0 0.3 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain C6 PF01681.17 OPL33642.1 - 0.11 13.1 7.1 0.19 12.3 0.6 3.0 2 1 1 3 3 3 0 C6 domain p450 PF00067.22 OPL33643.1 - 2.8e-106 356.1 0.0 3.1e-106 355.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PDCD7 PF16021.5 OPL33643.1 - 0.013 14.6 0.8 0.023 13.9 0.8 1.3 1 0 0 1 1 1 0 Programmed cell death protein 7 zf-B_box PF00643.24 OPL33645.1 - 9.1e-09 35.3 26.9 0.0002 21.4 4.6 2.2 2 0 0 2 2 2 2 B-box zinc finger zf-C4pol PF14260.6 OPL33645.1 - 0.032 14.7 21.7 0.12 12.9 16.6 3.1 1 1 2 3 3 3 0 C4-type zinc-finger of DNA polymerase delta zf-RRPl_C4 PF17026.5 OPL33645.1 - 0.41 10.8 18.5 8 6.6 0.5 2.3 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type SAM_1 PF00536.30 OPL33646.1 - 2.9e-05 24.4 0.0 6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ion_trans PF00520.31 OPL33647.1 - 0.0087 15.3 0.4 0.011 14.9 0.4 1.2 1 0 0 1 1 1 1 Ion transport protein Anophelin PF10731.9 OPL33647.1 - 0.053 13.4 0.0 0.079 12.8 0.0 1.3 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Shisa PF13908.6 OPL33647.1 - 0.16 12.2 0.4 0.17 12.1 0.4 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Glyco_transf_92 PF01697.27 OPL33648.1 - 1.9e-16 60.5 0.4 2.8e-16 60.0 0.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 92 DUF816 PF05674.12 OPL33649.1 - 0.0024 17.8 1.0 0.0035 17.3 0.1 1.7 2 1 0 2 2 2 1 Baculovirus protein of unknown function (DUF816) Kdo PF06293.14 OPL33649.1 - 0.084 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 OPL33649.1 - 0.2 11.0 2.0 0.28 10.5 0.6 1.8 1 1 1 2 2 2 0 Protein kinase domain Lectin_C PF00059.21 OPL33650.1 - 6.8e-08 33.2 2.5 7.4e-08 33.1 2.5 1.1 1 0 0 1 1 1 1 Lectin C-type domain Pelovaterin PF17859.1 OPL33650.1 - 0.007 16.6 0.1 0.013 15.8 0.1 1.4 1 0 0 1 1 1 1 Pelovaterin Ig_3 PF13927.6 OPL33651.1 - 8.9e-10 39.0 9.0 6.9e-05 23.4 0.9 3.5 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 OPL33651.1 - 5.1e-07 30.0 6.3 5.6e-05 23.4 0.4 3.0 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 OPL33651.1 - 4.2e-06 26.9 8.3 6.7e-05 23.0 0.2 3.3 4 1 0 4 4 4 2 Immunoglobulin domain I-set PF07679.16 OPL33651.1 - 5.5e-06 26.4 1.9 0.16 12.1 0.1 3.6 3 1 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 OPL33651.1 - 0.0026 17.9 0.7 0.19 11.9 0.1 2.9 3 0 0 3 3 3 1 Immunoglobulin V-set domain fn3 PF00041.21 OPL33654.1 - 0.0028 18.0 0.0 0.011 16.0 0.0 2.0 1 1 0 1 1 1 1 Fibronectin type III domain DUF2369 PF10179.9 OPL33654.1 - 0.01 16.2 0.0 0.024 15.0 0.0 1.7 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 OPL33654.1 - 0.02 15.5 0.0 0.053 14.1 0.0 1.8 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain AAA_27 PF13514.6 OPL33654.1 - 0.21 11.2 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF5607 PF18355.1 OPL33656.1 - 0.15 12.5 0.0 0.24 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5607) EF_assoc_2 PF08356.12 OPL33658.1 - 8.5e-35 118.6 0.0 1.7e-34 117.7 0.0 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 OPL33658.1 - 4.6e-08 32.8 0.0 7.5e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Ras family EF-hand_1 PF00036.32 OPL33658.1 - 9e-08 31.1 0.0 0.00042 19.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 OPL33658.1 - 1.5e-07 30.7 0.0 0.00068 19.4 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 OPL33658.1 - 1.2e-06 28.9 0.0 0.073 13.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 OPL33658.1 - 0.00091 19.5 0.0 0.77 10.1 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 OPL33658.1 - 0.02 14.4 0.1 0.091 12.3 0.0 2.0 2 0 0 2 2 2 0 EF hand EF_assoc_1 PF08355.12 OPL33658.1 - 0.083 12.5 1.7 1.3 8.7 0.4 2.4 2 0 0 2 2 2 0 EF hand associated EF-hand_10 PF14788.6 OPL33658.1 - 0.14 12.0 0.4 1.9 8.4 0.1 2.3 2 0 0 2 2 2 0 EF hand EF_assoc_1 PF08355.12 OPL33659.1 - 2.5e-12 46.2 0.1 3.1e-12 45.9 0.1 1.1 1 0 0 1 1 1 1 EF hand associated OPA3 PF07047.12 OPL33660.1 - 6.7e-25 87.3 0.0 1.1e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) SOGA PF11365.8 OPL33660.1 - 0.0014 19.7 1.7 0.0024 18.9 1.7 1.3 1 0 0 1 1 1 1 Protein SOGA RIC3 PF15361.6 OPL33660.1 - 0.029 14.8 0.9 0.047 14.1 0.9 1.3 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Pox_A_type_inc PF04508.12 OPL33660.1 - 0.082 12.8 0.2 0.21 11.5 0.2 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat TSC22 PF01166.18 OPL33660.1 - 0.2 12.0 2.0 0.44 10.9 0.3 2.4 3 0 0 3 3 3 0 TSC-22/dip/bun family HSP70 PF00012.20 OPL33661.1 - 1.1e-10 40.4 0.1 1.7e-09 36.5 0.1 2.1 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL33661.1 - 0.018 13.9 0.8 0.06 12.2 0.1 2.1 2 1 0 2 2 2 0 MreB/Mbl protein StbA PF06406.11 OPL33661.1 - 0.025 13.8 1.6 0.87 8.8 0.3 2.4 2 1 0 2 2 2 0 StbA protein BcrAD_BadFG PF01869.20 OPL33661.1 - 0.052 13.0 0.1 0.18 11.3 0.0 1.8 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.10 OPL33661.1 - 0.27 10.2 1.0 9.4 5.1 0.3 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain PEN-2 PF10251.9 OPL33662.1 - 0.042 14.3 0.1 0.082 13.3 0.1 1.4 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase Ig_3 PF13927.6 OPL33663.1 - 0.00097 19.7 0.9 0.14 12.8 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 OPL33663.1 - 0.007 16.5 1.2 1.7 8.8 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 OPL33663.1 - 0.0074 16.5 0.7 0.52 10.5 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain ComX PF05952.12 OPL33663.1 - 0.013 15.5 0.1 4.6 7.2 0.0 2.5 2 0 0 2 2 2 0 Bacillus competence pheromone ComX 5_nucleotid_C PF02872.18 OPL33664.1 - 3.2e-10 40.4 0.1 2.6e-09 37.5 0.0 2.2 1 1 1 2 2 2 1 5'-nucleotidase, C-terminal domain Plexin_cytopl PF08337.12 OPL33665.1 - 1.3e-10 40.6 0.1 1.4e-10 40.5 0.1 1.0 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Rax2 PF12768.7 OPL33666.1 - 0.0067 15.9 2.3 0.011 15.2 2.4 1.3 1 1 0 1 1 1 1 Cortical protein marker for cell polarity Herpes_gE PF02480.16 OPL33666.1 - 0.04 12.7 0.4 0.047 12.4 0.4 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E TIG PF01833.24 OPL33667.1 - 8.6e-10 38.6 3.0 7.3e-06 26.0 0.1 2.2 2 0 0 2 2 2 2 IPT/TIG domain Profilin PF00235.19 OPL33668.1 - 0.0032 17.7 0.1 2 8.7 0.0 3.2 3 0 0 3 3 3 2 Profilin Cu-oxidase_3 PF07732.15 OPL33669.1 - 6.9e-06 26.1 0.1 0.088 12.8 0.0 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 OPL33669.1 - 4.7e-05 23.1 0.1 0.0036 17.0 0.1 2.6 3 0 0 3 3 3 2 Multicopper oxidase Ig_3 PF13927.6 OPL33670.1 - 7.6e-13 48.9 1.8 0.00074 20.1 0.1 3.3 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 OPL33670.1 - 1e-08 35.1 0.1 2.4e-07 30.7 0.1 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 OPL33670.1 - 1.4e-06 28.5 2.1 0.0037 17.6 0.0 3.9 3 1 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 OPL33670.1 - 5.4e-06 26.4 2.4 0.005 16.9 0.1 3.8 3 2 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 OPL33670.1 - 9.1e-06 25.8 3.2 0.35 11.1 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 OPL33670.1 - 0.022 15.1 1.1 0.39 11.1 0.1 3.2 4 0 0 4 4 4 0 Immunoglobulin C1-set domain V-set PF07686.17 OPL33670.1 - 0.11 12.7 0.3 25 5.1 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin V-set domain Syndecan PF01034.20 OPL33670.1 - 1.9 8.4 6.1 4.1 7.4 6.1 1.5 1 0 0 1 1 1 0 Syndecan domain AAA_12 PF13087.6 OPL33671.1 - 1.3e-39 135.9 2.0 8.6e-38 130.0 0.2 3.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 OPL33671.1 - 7e-30 104.7 5.2 7e-30 104.7 5.2 4.5 4 2 0 4 4 4 1 AAA domain AAA_30 PF13604.6 OPL33671.1 - 2.7e-06 27.2 0.0 0.0072 16.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 OPL33671.1 - 4e-06 27.2 0.0 7.3e-05 23.1 0.0 2.5 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 OPL33671.1 - 0.00045 19.7 0.0 0.0011 18.5 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein ResIII PF04851.15 OPL33671.1 - 0.00056 19.9 2.0 0.0013 18.7 0.2 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA PF00004.29 OPL33671.1 - 0.0062 17.0 0.0 0.031 14.7 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) BRD4_CDT PF17105.5 OPL33671.1 - 0.037 13.6 0.1 0.24 11.0 0.0 2.4 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 AAA_5 PF07728.14 OPL33671.1 - 0.053 13.5 0.0 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 OPL33671.1 - 0.079 13.2 0.0 0.7 10.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain 7tm_1 PF00001.21 OPL33673.1 - 8e-24 84.4 7.4 9.8e-24 84.1 7.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 OPL33673.1 - 4.3e-08 32.8 6.4 6e-08 32.4 6.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 OPL33673.1 - 6.4e-05 22.5 4.7 8.6e-05 22.0 3.7 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx NCD1 PF04904.13 OPL33674.1 - 1.2e-06 28.4 0.0 6.4e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 NAB conserved region 1 (NCD1) DDE_Tnp_ISAZ013 PF07592.11 OPL33675.1 - 0.076 12.0 0.4 0.11 11.5 0.4 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain Ribosomal_S19e PF01090.19 OPL33675.1 - 0.079 12.7 0.3 0.17 11.6 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein S19e UPF0236 PF06782.11 OPL33675.1 - 0.15 10.7 2.2 0.21 10.2 2.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) C1q PF00386.21 OPL33678.1 - 4.3e-20 72.2 0.1 5.9e-20 71.8 0.1 1.2 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 OPL33678.1 - 0.0001 22.2 0.0 0.00013 21.8 0.0 1.1 1 0 0 1 1 1 1 BclA C-terminal domain TNF PF00229.18 OPL33678.1 - 0.011 15.7 0.1 0.84 9.6 0.0 2.3 1 1 1 2 2 2 0 TNF(Tumour Necrosis Factor) family Fibrinogen_C PF00147.18 OPL33679.1 - 2.4e-69 233.5 15.1 2.4e-69 233.5 15.1 1.3 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 OPL33679.1 - 0.019 14.2 0.0 0.039 13.3 0.0 1.6 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain PDZ_6 PF17820.1 OPL33682.1 - 1.3e-12 47.4 0.1 4.1e-12 45.8 0.1 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 OPL33682.1 - 9e-12 45.2 0.0 1.7e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DIL PF01843.19 OPL33682.1 - 9.3e-12 45.2 0.0 2.2e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 DIL domain PDZ_2 PF13180.6 OPL33682.1 - 6.6e-05 23.1 0.0 0.00012 22.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain HEPN PF05168.14 OPL33684.1 - 6.1e-15 55.4 0.2 3.4e-13 49.7 0.1 2.8 2 0 0 2 2 2 1 HEPN domain DnaJ PF00226.31 OPL33684.1 - 0.0014 18.7 0.1 0.015 15.4 0.0 2.5 2 0 0 2 2 2 1 DnaJ domain HATPase_c_3 PF13589.6 OPL33684.1 - 0.018 14.9 0.1 1 9.2 0.0 3.2 2 1 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase S-methyl_trans PF02574.16 OPL33685.1 - 9.8e-35 120.7 0.0 1.2e-34 120.3 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase F5_F8_type_C PF00754.25 OPL33686.1 - 9.6e-08 32.2 0.0 4.3e-06 26.9 0.0 2.4 3 0 0 3 3 3 2 F5/8 type C domain Fibrinogen_C PF00147.18 OPL33687.1 - 6.8e-68 228.8 9.7 8.2e-68 228.5 9.7 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain SGP PF17228.2 OPL33688.1 - 0.17 12.7 5.8 0.22 12.4 5.8 1.2 1 0 0 1 1 1 0 Sulphur globule protein DUF126 PF01989.16 OPL33689.1 - 0.054 13.3 0.2 0.33 10.8 0.0 2.3 2 0 0 2 2 2 0 Aconitase X swivel domain V-set PF07686.17 OPL33690.1 - 0.00026 21.1 0.0 0.00034 20.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 OPL33690.1 - 0.016 15.8 0.0 0.02 15.5 0.0 1.4 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 OPL33690.1 - 0.023 14.7 0.0 0.032 14.3 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.25 OPL33690.1 - 0.026 14.7 0.0 0.041 14.1 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Sema PF01403.19 OPL33691.1 - 2.2e-12 46.6 0.1 2.3e-12 46.5 0.1 1.0 1 0 0 1 1 1 1 Sema domain Sema PF01403.19 OPL33692.1 - 1.6e-22 79.9 0.0 1.7e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 OPL33692.1 - 0.0096 16.4 0.6 0.017 15.7 0.6 1.4 1 0 0 1 1 1 1 Plexin repeat Lipocalin_7 PF14651.6 OPL33693.1 - 2.7e-07 30.5 0.9 5.6e-07 29.5 0.9 1.5 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family TIR_2 PF13676.6 OPL33694.1 - 3.2e-21 76.1 0.0 1.4e-20 74.1 0.0 2.0 2 0 0 2 2 2 1 TIR domain TIR PF01582.20 OPL33694.1 - 2.9e-10 40.2 1.7 4e-10 39.8 1.1 1.5 2 0 0 2 2 2 1 TIR domain DUF1863 PF08937.11 OPL33694.1 - 0.00012 22.4 1.0 0.0006 20.1 0.9 1.9 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) TIR-like PF10137.9 OPL33694.1 - 0.049 13.6 0.1 0.08 12.9 0.1 1.4 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Sld3_N PF18523.1 OPL33694.1 - 0.061 13.4 0.2 0.15 12.2 0.2 1.6 1 0 0 1 1 1 0 Sld3 N-terminal domain Exo_endo_phos_2 PF14529.6 OPL33697.1 - 0.00084 19.2 0.1 0.0013 18.5 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase HSP70 PF00012.20 OPL33700.1 - 2.2e-12 46.0 0.0 2.8e-11 42.3 0.0 2.1 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL33700.1 - 0.001 18.0 0.3 0.19 10.5 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein BcrAD_BadFG PF01869.20 OPL33700.1 - 0.0044 16.6 0.0 0.0078 15.7 0.0 1.4 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family TPR_1 PF00515.28 OPL33701.1 - 1.5e-10 40.4 0.1 3.5e-05 23.4 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 OPL33701.1 - 1.7e-08 33.9 0.3 0.028 14.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 OPL33701.1 - 4e-07 30.2 0.1 1.6e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 OPL33701.1 - 1.2e-05 25.2 0.7 0.014 15.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 OPL33701.1 - 0.001 19.7 0.0 1.3 10.0 0.1 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat NYD-SP12_N PF15015.6 OPL33701.1 - 0.0025 16.3 0.0 0.0034 15.8 0.0 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated, N-terminal TPR_10 PF13374.6 OPL33701.1 - 0.015 15.2 0.5 0.25 11.3 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.6 OPL33701.1 - 0.019 14.2 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 OPL33701.1 - 0.026 15.2 0.1 7.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 OPL33701.1 - 0.078 13.1 0.3 0.53 10.4 0.0 2.5 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 OPL33701.1 - 0.1 13.0 0.0 0.36 11.3 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Ank_5 PF13857.6 OPL33701.1 - 0.15 12.4 0.1 4.7 7.7 0.0 2.9 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank PF00023.30 OPL33701.1 - 0.28 11.7 0.1 0.28 11.7 0.1 2.5 3 0 0 3 3 2 0 Ankyrin repeat TPR_2 PF07719.17 OPL33702.1 - 3.8e-07 29.7 3.0 0.047 13.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 OPL33702.1 - 5.5e-07 29.1 3.0 0.11 12.3 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 OPL33702.1 - 0.018 14.7 0.9 6.3 6.6 0.2 2.6 2 0 0 2 2 2 0 TPR repeat TPR_6 PF13174.6 OPL33702.1 - 0.024 15.2 0.4 2.4 9.0 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.20 OPL33702.1 - 0.028 14.3 0.4 0.051 13.4 0.1 1.6 2 0 0 2 2 2 0 Region in Clathrin and VPS TPR_8 PF13181.6 OPL33702.1 - 0.04 14.1 0.9 3.8 8.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3730 PF12530.8 OPL33702.1 - 0.045 13.3 0.2 0.054 13.1 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3730) TPR_16 PF13432.6 OPL33702.1 - 0.16 12.7 0.4 24 5.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DED PF01335.21 OPL33703.1 - 1.7e-13 50.7 0.9 1.7e-13 50.7 0.9 3.5 3 0 0 3 3 3 1 Death effector domain Nucleic_acid_bd PF13820.6 OPL33703.1 - 0.029 14.2 0.1 0.21 11.4 0.0 2.4 1 1 0 2 2 2 0 Putative nucleic acid-binding region MlaD PF02470.20 OPL33703.1 - 0.095 13.0 0.1 0.27 11.6 0.1 1.7 1 0 0 1 1 1 0 MlaD protein FlgM PF04316.13 OPL33703.1 - 0.12 12.8 0.1 0.4 11.1 0.1 1.9 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM PYRIN PF02758.16 OPL33703.1 - 0.15 12.3 2.0 0.73 10.0 0.3 3.2 3 0 0 3 3 3 0 PAAD/DAPIN/Pyrin domain DAG_kinase_N PF14513.6 OPL33703.1 - 1.4 9.1 8.4 0.58 10.4 0.4 3.1 3 0 0 3 3 3 0 Diacylglycerol kinase N-terminus OEP PF02321.18 OPL33703.1 - 2.5 7.9 10.0 4.8 6.9 0.1 2.6 2 0 0 2 2 2 0 Outer membrane efflux protein C1q PF00386.21 OPL33704.1 - 7.6e-16 58.5 0.3 1.2e-15 57.8 0.3 1.3 1 0 0 1 1 1 1 C1q domain DUF669 PF05037.13 OPL33704.1 - 0.0019 18.4 0.0 0.0031 17.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF669) PPC PF04151.15 OPL33704.1 - 0.095 13.8 0.9 0.22 12.6 0.2 2.0 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain AKNA PF12443.8 OPL33706.1 - 0.085 13.5 5.1 0.29 11.8 1.3 2.1 1 1 1 2 2 2 0 AT-hook-containing transcription factor Shugoshin_N PF07558.11 OPL33706.1 - 0.28 11.1 3.7 5 7.1 0.5 2.6 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region BIR PF00653.21 OPL33707.1 - 1.4e-38 131.4 5.7 4.5e-20 72.1 2.2 2.4 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain Fibrinogen_C PF00147.18 OPL33708.1 - 1.4e-116 388.0 24.9 2.2e-69 233.7 8.9 3.1 2 1 1 3 3 3 3 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 OPL33708.1 - 4.5e-05 22.9 0.3 0.093 12.0 0.0 2.3 2 0 0 2 2 2 2 Fibrillar collagen C-terminal domain DUF5104 PF17117.5 OPL33708.1 - 0.053 14.0 5.7 0.54 10.7 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5104) Osmo_CC PF08946.10 OPL33708.1 - 0.4 11.0 2.5 2.2 8.6 0.7 2.3 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Lectin_C PF00059.21 OPL33708.1 - 1.1 10.0 8.3 2 9.2 0.2 3.4 3 1 1 4 4 4 0 Lectin C-type domain Excalibur PF05901.11 OPL33708.1 - 4.1 8.1 7.1 43 4.8 1.3 4.0 3 1 0 3 3 3 0 Excalibur calcium-binding domain Lectin_C PF00059.21 OPL33709.1 - 3.3e-08 34.2 0.0 3.5e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Lectin C-type domain SnoaL_2 PF12680.7 OPL33709.1 - 0.062 14.0 0.0 0.072 13.7 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain Chitin_synth_2 PF03142.15 OPL33710.1 - 5.1e-12 45.2 0.7 1e-08 34.3 0.4 2.2 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 OPL33710.1 - 1.4e-08 34.9 0.3 2.7e-07 30.7 0.2 2.2 1 1 1 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 OPL33710.1 - 0.0002 21.2 0.0 0.00031 20.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 OPL33710.1 - 0.00039 20.4 0.0 0.0011 18.9 0.1 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 OPL33710.1 - 0.08 12.4 0.0 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 21 VWD PF00094.25 OPL33711.1 - 1.4e-12 48.1 0.1 2.4e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain DUF3377 PF11857.8 OPL33712.1 - 0.00017 21.4 0.7 0.00039 20.3 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) Shisa PF13908.6 OPL33712.1 - 0.00066 20.0 0.7 0.001 19.3 0.7 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF4448 PF14610.6 OPL33712.1 - 0.0012 18.7 0.1 0.0017 18.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 OPL33712.1 - 0.0059 16.5 0.2 0.0099 15.8 0.2 1.3 1 0 0 1 1 1 1 TMEM154 protein family AMA-1 PF02430.15 OPL33712.1 - 0.012 14.6 0.6 0.017 14.1 0.6 1.1 1 0 0 1 1 1 0 Apical membrane antigen 1 Protocadherin PF08374.11 OPL33712.1 - 0.019 15.0 0.1 0.028 14.4 0.1 1.2 1 0 0 1 1 1 0 Protocadherin Mycobact_memb PF05423.13 OPL33712.1 - 0.024 14.5 0.1 0.041 13.8 0.1 1.3 1 0 0 1 1 1 0 Mycobacterium membrane protein PRIMA1 PF16101.5 OPL33712.1 - 0.038 14.0 0.2 0.064 13.3 0.2 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EGF_2 PF07974.13 OPL33712.1 - 0.18 12.2 2.3 0.52 10.7 2.3 1.8 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.27 OPL33713.1 - 2.4e-26 91.7 45.4 2.4e-09 37.3 8.4 3.3 3 1 0 3 3 3 3 EGF-like domain hEGF PF12661.7 OPL33713.1 - 2.4e-21 75.5 43.6 2.7e-07 30.9 7.9 4.1 4 0 0 4 4 4 3 Human growth factor-like EGF EGF_CA PF07645.15 OPL33713.1 - 4e-11 42.9 48.7 5.8e-05 23.2 10.7 3.1 2 1 1 3 3 3 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 OPL33713.1 - 2.8e-07 30.7 40.6 0.00099 19.3 7.9 3.6 1 1 2 3 3 3 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 OPL33713.1 - 6.6e-06 26.2 46.3 0.063 13.5 8.6 4.3 2 2 1 3 3 3 3 EGF domain EGF_2 PF07974.13 OPL33713.1 - 0.00011 22.5 49.6 0.048 14.0 9.1 3.3 3 0 0 3 3 3 3 EGF-like domain Plasmod_Pvs28 PF06247.11 OPL33713.1 - 0.00025 21.3 42.9 0.063 13.6 12.0 3.2 3 0 0 3 3 3 3 Pvs28 EGF domain cEGF PF12662.7 OPL33713.1 - 0.071 13.1 3.7 0.071 13.1 3.7 7.0 5 2 1 6 6 6 0 Complement Clr-like EGF-like Laminin_EGF PF00053.24 OPL33713.1 - 0.17 12.1 42.6 0.63 10.2 8.2 3.4 2 1 1 3 3 3 0 Laminin EGF domain TSP_1 PF00090.19 OPL33715.1 - 3.4e-16 59.2 34.7 1.5e-09 37.9 8.1 4.1 4 0 0 4 4 4 2 Thrombospondin type 1 domain CBM_14 PF01607.24 OPL33715.1 - 6.9e-12 45.3 7.3 6.9e-12 45.3 7.3 6.5 7 2 0 7 7 7 1 Chitin binding Peritrophin-A domain Sushi PF00084.20 OPL33715.1 - 4.3e-10 40.0 8.3 1e-08 35.7 2.2 6.4 5 0 0 5 5 5 2 Sushi repeat (SCR repeat) EGF PF00008.27 OPL33715.1 - 2.3e-08 34.2 19.6 7.5e-06 26.2 6.9 7.4 7 2 1 8 8 8 2 EGF-like domain DUF3011 PF11218.8 OPL33715.1 - 3.7e-07 30.3 7.9 3.7e-07 30.3 7.9 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF3011) hEGF PF12661.7 OPL33715.1 - 0.00039 20.9 21.1 0.00084 19.9 6.2 7.0 7 1 0 7 7 7 2 Human growth factor-like EGF GMC_oxred_N PF00732.19 OPL33716.1 - 4.9e-13 49.1 0.0 6.3e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 OPL33716.1 - 7.9e-05 21.9 0.1 9.9e-05 21.5 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 OPL33716.1 - 8.2e-05 22.0 0.0 9e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 OPL33716.1 - 0.00011 22.4 0.1 0.00019 21.6 0.1 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 OPL33716.1 - 0.0025 17.5 0.1 0.0031 17.1 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 OPL33716.1 - 0.0026 17.1 0.1 0.0035 16.6 0.1 1.1 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 OPL33716.1 - 0.012 14.8 0.1 0.015 14.4 0.1 1.1 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 OPL33716.1 - 0.033 14.4 0.1 0.046 14.0 0.1 1.2 1 0 0 1 1 1 0 TrkA-N domain Trp_halogenase PF04820.14 OPL33716.1 - 0.037 12.9 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase HI0933_like PF03486.14 OPL33716.1 - 0.069 11.8 0.0 0.082 11.6 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.19 OPL33716.1 - 0.18 11.0 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Kunitz_BPTI PF00014.23 OPL33717.1 - 3.1e-18 65.8 10.2 3.8e-18 65.5 10.2 1.1 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain zf_CCCH_5 PF18384.1 OPL33717.1 - 0.049 13.8 0.3 0.049 13.8 0.3 2.0 2 0 0 2 2 2 0 Unkempt Zinc finger domain 1 (Znf1) Rho_GDI PF02115.17 OPL33719.1 - 0.048 13.4 0.2 0.08 12.7 0.2 1.4 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor Pox_J1 PF03338.15 OPL33721.1 - 0.055 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Poxvirus J1 protein C2 PF00168.30 OPL33722.1 - 4.3e-21 75.1 0.0 7e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.9 OPL33723.1 - 1.5e-10 41.4 9.0 1.2e-05 25.5 0.2 3.3 3 1 1 4 4 4 2 Munc13 (mammalian uncoordinated) homology domain CAMSAP_CH PF11971.8 OPL33723.1 - 0.067 13.0 0.0 0.27 11.1 0.0 2.1 1 0 0 1 1 1 0 CAMSAP CH domain CARD PF00619.21 OPL33724.1 - 2.7e-11 43.3 0.0 6.1e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 OPL33724.1 - 8.1e-05 22.5 0.0 0.00023 21.1 0.0 1.8 1 0 0 1 1 1 1 Caspase recruitment domain TDRP PF15683.5 OPL33725.1 - 0.065 13.2 1.0 0.099 12.6 1.0 1.4 1 1 0 1 1 1 0 Testis development-related protein PRP1_N PF06424.12 OPL33725.1 - 0.11 12.8 3.6 0.15 12.4 3.6 1.3 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Neur_chan_LBD PF02931.23 OPL33726.1 - 4.5e-24 85.1 1.9 6.2e-23 81.4 0.1 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain DUF1509 PF07420.11 OPL33726.1 - 0.0061 15.6 0.2 0.0078 15.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1509) Macro PF01661.21 OPL33727.1 - 4.9e-23 81.4 0.3 2.1e-22 79.4 0.1 2.2 2 0 0 2 2 2 1 Macro domain RRM_1 PF00076.22 OPL33727.1 - 6.3e-06 25.9 0.2 0.099 12.5 0.0 3.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 OPL33727.1 - 0.042 13.6 0.4 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain NID PF07292.13 OPL33727.1 - 0.076 13.7 16.9 0.19 12.4 0.2 6.2 6 2 0 6 6 6 0 Nmi/IFP 35 domain (NID) SLS PF14611.6 OPL33727.1 - 0.26 11.1 6.8 0.52 10.1 1.9 3.1 3 1 0 3 3 3 0 Mitochondrial inner-membrane-bound regulator DUF2067 PF09840.9 OPL33727.1 - 1.5 8.4 5.8 2 7.9 0.4 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2067) Macro PF01661.21 OPL33728.1 - 8.5e-07 29.0 0.0 2e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 Macro domain Gaa1 PF04114.14 OPL33728.1 - 0.13 11.3 0.1 0.16 11.0 0.1 1.1 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component HMMR_C PF15908.5 OPL33729.1 - 0.01 16.1 1.3 0.012 15.9 1.3 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal Transmemb_17 PF09799.9 OPL33730.1 - 3.1e-26 92.1 16.7 4.3e-26 91.6 16.7 1.2 1 0 0 1 1 1 1 Predicted membrane protein PARP PF00644.20 OPL33731.1 - 1.6e-28 99.7 3.1 1e-26 93.8 3.1 2.2 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 OPL33731.1 - 0.00041 20.9 0.7 0.00085 19.9 0.1 1.9 2 0 0 2 2 2 1 WWE domain RNase_P_pop3 PF08228.11 OPL33731.1 - 0.11 12.5 0.2 0.22 11.5 0.0 1.5 2 0 0 2 2 2 0 RNase P subunit Pop3 SLS PF14611.6 OPL33731.1 - 0.15 11.8 2.2 0.57 10.0 2.2 2.0 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator bZIP_1 PF00170.21 OPL33732.1 - 1.1e-06 28.6 13.4 1.8e-06 27.9 13.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 OPL33732.1 - 1.2e-06 28.4 14.7 1.8e-06 28.0 14.2 1.5 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 OPL33732.1 - 8.9e-05 22.9 8.6 0.00015 22.2 8.6 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF3811 PF11656.8 OPL33732.1 - 0.076 13.4 4.5 0.047 14.1 2.5 1.7 1 1 0 1 1 1 0 YjbD family (DUF3811) HH_signal PF01085.18 OPL33732.1 - 0.11 12.2 0.2 0.14 11.8 0.2 1.1 1 0 0 1 1 1 0 Hedgehog amino-terminal signalling domain DUF641 PF04859.12 OPL33732.1 - 0.18 12.2 3.6 0.25 11.7 3.6 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) bZIP_1 PF00170.21 OPL33733.1 - 1.5e-08 34.6 13.4 2.9e-08 33.7 13.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 OPL33733.1 - 1.1e-07 31.8 11.5 1.1e-07 31.8 11.5 2.6 1 1 2 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.17 OPL33733.1 - 5.8e-05 23.5 12.6 7.1e-05 23.3 12.1 1.4 1 1 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 OPL33734.1 - 2.5e-09 37.1 10.6 2.5e-09 37.1 10.6 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 OPL33734.1 - 5.9e-09 35.9 9.6 5.9e-09 35.9 9.6 2.6 2 1 0 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.17 OPL33734.1 - 0.00026 21.5 11.8 0.00026 21.5 11.8 1.9 2 0 0 2 2 2 1 bZIP Maf transcription factor Snapin_Pallidin PF14712.6 OPL33734.1 - 0.015 15.7 2.6 0.015 15.7 2.6 2.2 2 1 0 2 2 2 0 Snapin/Pallidin HeLo PF14479.6 OPL33734.1 - 0.023 14.5 4.4 0.03 14.1 4.4 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation TMF_DNA_bd PF12329.8 OPL33734.1 - 0.23 11.5 13.2 0.086 12.9 5.1 2.7 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF5320 PF17253.2 OPL33734.1 - 0.67 11.1 3.7 2.4 9.3 1.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5320) XhlA PF10779.9 OPL33734.1 - 1 9.6 9.3 0.12 12.6 4.2 2.0 2 0 0 2 2 2 0 Haemolysin XhlA FlaC_arch PF05377.11 OPL33734.1 - 2 8.9 8.2 0.47 10.9 1.8 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) C1q PF00386.21 OPL33735.1 - 1.1e-13 51.5 0.1 1.4e-13 51.1 0.1 1.2 1 0 0 1 1 1 1 C1q domain C1q PF00386.21 OPL33736.1 - 2.9e-17 63.1 0.0 3.5e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 C1q domain MazE_antitoxin PF04014.18 OPL33736.1 - 0.04 13.9 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin BclA_C PF18573.1 OPL33736.1 - 0.08 12.9 0.4 0.091 12.7 0.4 1.1 1 0 0 1 1 1 0 BclA C-terminal domain TNF PF00229.18 OPL33736.1 - 0.084 12.8 0.0 0.71 9.8 0.0 2.1 1 1 0 1 1 1 0 TNF(Tumour Necrosis Factor) family Roc PF08477.13 OPL33737.1 - 1.9e-15 57.1 0.3 3.2e-08 33.8 0.1 3.1 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 OPL33737.1 - 3.9e-15 56.2 3.6 5.6e-15 55.7 1.8 2.1 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain Ras PF00071.22 OPL33737.1 - 5.2e-06 26.1 0.1 0.076 12.6 0.0 2.7 2 0 0 2 2 2 2 Ras family AAA_21 PF13304.6 OPL33737.1 - 0.0059 16.5 1.3 0.0091 15.8 0.1 2.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 OPL33737.1 - 0.008 16.1 0.1 0.023 14.6 0.1 1.8 1 0 0 1 1 1 1 RsgA GTPase DUF1322 PF07032.11 OPL33737.1 - 0.019 15.5 0.2 0.065 13.8 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1322) baeRF_family5 PF18846.1 OPL33737.1 - 0.021 15.0 0.2 0.098 12.9 0.2 2.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 5 MMR_HSR1 PF01926.23 OPL33737.1 - 0.028 14.5 0.0 0.26 11.4 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 OPL33737.1 - 0.043 13.5 0.7 0.22 11.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 OPL33737.1 - 0.063 13.7 0.1 2.8 8.4 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 OPL33737.1 - 0.08 13.5 3.7 0.15 12.6 1.7 2.6 2 1 0 2 2 2 0 ABC transporter PduV-EutP PF10662.9 OPL33737.1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 OPL33737.1 - 0.17 12.2 0.0 0.75 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain DUF2624 PF11116.8 OPL33737.1 - 2.1 9.3 10.0 0.65 10.9 0.6 3.7 4 0 0 4 4 3 0 Protein of unknown function (DUF2624) EGF PF00008.27 OPL33738.1 - 3e-07 30.6 16.9 7.9e-05 22.9 2.7 5.1 4 1 1 5 5 5 2 EGF-like domain hEGF PF12661.7 OPL33738.1 - 4.7e-07 30.2 18.0 9.3e-05 22.9 5.2 4.7 5 0 0 5 5 5 2 Human growth factor-like EGF EGF_CA PF07645.15 OPL33738.1 - 0.00012 22.2 4.6 0.00012 22.2 4.6 4.3 4 1 0 4 4 4 1 Calcium-binding EGF domain VWC PF00093.18 OPL33738.1 - 0.00037 20.8 18.0 0.00037 20.8 18.0 3.3 2 2 0 2 2 2 1 von Willebrand factor type C domain Pacifastin_I PF05375.13 OPL33738.1 - 0.00055 19.6 9.3 0.00055 19.6 9.3 3.6 4 0 0 4 4 4 1 Pacifastin inhibitor (LCMII) EGF_alliinase PF04863.13 OPL33738.1 - 0.0026 18.1 2.1 0.0026 18.1 2.1 3.7 4 1 0 4 4 4 1 Alliinase EGF-like domain Y_phosphatase PF00102.27 OPL33739.1 - 0.05 13.2 0.3 0.095 12.2 0.3 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Trp_dioxygenase PF03301.13 OPL33741.1 - 1.3e-34 120.1 0.1 1.5e-34 119.8 0.1 1.0 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase Bromodomain PF00439.25 OPL33744.1 - 3.3e-09 36.7 0.1 8.7e-09 35.3 0.1 1.8 1 0 0 1 1 1 1 Bromodomain 7tm_2 PF00002.24 OPL33748.1 - 2.4e-20 72.9 12.1 3.5e-20 72.3 12.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 OPL33748.1 - 2.5e-09 37.5 1.0 2.5e-09 37.5 1.0 2.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif stn_TNFRSF12A PF12191.8 OPL33748.1 - 0.077 13.2 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain GAIN PF16489.5 OPL33749.1 - 4e-11 42.7 1.8 5e-11 42.4 1.3 1.4 2 0 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain HRM PF02793.22 OPL33749.1 - 3e-08 33.8 2.6 3e-08 33.8 2.6 1.8 2 0 0 2 2 2 1 Hormone receptor domain EGF PF00008.27 OPL33749.1 - 0.0012 19.1 4.6 0.0034 17.7 4.6 1.8 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 OPL33749.1 - 0.13 12.7 11.7 0.45 10.9 11.7 2.0 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 OPL33749.1 - 0.85 10.3 8.4 0.15 12.7 3.1 2.5 2 0 0 2 2 2 0 Human growth factor-like EGF 7tm_1 PF00001.21 OPL33751.1 - 5.9e-27 94.6 13.3 7.6e-27 94.3 13.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3404 PF11884.8 OPL33751.1 - 0.23 10.6 0.6 0.45 9.7 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3404) Git3 PF11710.8 OPL33751.1 - 0.81 9.4 17.2 1.6 8.5 17.2 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 HATPase_c_3 PF13589.6 OPL33752.1 - 0.0053 16.6 0.1 0.091 12.6 0.1 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Abi_2 PF07751.11 OPL33752.1 - 0.093 13.0 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Abi-like protein HEPN PF05168.14 OPL33753.1 - 2.7e-09 37.2 2.9 1.3e-07 31.8 0.0 3.9 5 0 0 5 5 5 1 HEPN domain HATPase_c_3 PF13589.6 OPL33753.1 - 0.001 18.9 0.0 0.0032 17.3 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DnaJ PF00226.31 OPL33753.1 - 0.017 15.3 0.0 0.063 13.4 0.0 2.0 1 0 0 1 1 1 0 DnaJ domain WWE PF02825.20 OPL33755.1 - 3.5e-12 46.7 0.3 4.2e-12 46.5 0.3 1.1 1 0 0 1 1 1 1 WWE domain MIB_HERC2 PF06701.13 OPL33756.1 - 4.2e-21 75.0 4.7 2.4e-11 43.7 0.1 3.0 2 1 0 2 2 2 2 Mib_herc2 SH3_15 PF18346.1 OPL33756.1 - 0.48 10.8 4.5 2.1 8.7 2.7 2.7 2 1 0 2 2 2 0 Mind bomb SH3 repeat domain Cadherin PF00028.17 OPL33757.1 - 1.3e-16 60.8 2.5 2e-10 41.0 0.1 2.3 2 0 0 2 2 2 2 Cadherin domain Cadherin_3 PF16184.5 OPL33757.1 - 0.00049 20.1 1.0 0.25 11.4 0.2 2.3 2 0 0 2 2 2 2 Cadherin-like fn3 PF00041.21 OPL33759.1 - 8.7e-14 51.6 0.0 1.6e-05 25.1 0.0 2.2 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 OPL33759.1 - 0.00087 19.8 1.1 0.57 10.8 0.2 2.4 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain TRI5 PF06330.11 OPL33759.1 - 0.011 14.6 1.3 0.03 13.2 0.0 2.1 3 0 0 3 3 3 0 Trichodiene synthase (TRI5) Mig-14 PF07395.11 OPL33759.1 - 0.016 14.6 0.0 0.86 8.9 0.0 2.1 2 0 0 2 2 2 0 Mig-14 DUF2290 PF10053.9 OPL33759.1 - 0.033 13.7 0.2 2.7 7.4 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2290) zf-CSL PF05207.13 OPL33759.1 - 0.036 13.8 0.4 7.5 6.4 0.0 2.5 2 0 0 2 2 2 0 CSL zinc finger NTase_sub_bind PF08780.11 OPL33759.1 - 0.037 14.0 1.9 5.8 6.9 0.1 2.1 2 0 0 2 2 2 0 Nucleotidyltransferase substrate binding protein like Lar_restr_allev PF14354.6 OPL33759.1 - 0.12 12.8 0.2 13 6.3 0.0 2.4 2 0 0 2 2 2 0 Restriction alleviation protein Lar SEFIR PF08357.11 OPL33760.1 - 5.1e-30 104.7 0.1 9.2e-30 103.9 0.1 1.5 1 0 0 1 1 1 1 SEFIR domain E1_4HB PF16191.5 OPL33760.1 - 0.072 13.3 0.2 3.8 7.8 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin-activating enzyme E1 four-helix bundle Fibrinogen_C PF00147.18 OPL33761.1 - 1.9e-34 119.4 2.6 2.1e-34 119.2 2.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 OPL33762.1 - 1.4e-57 195.1 6.0 1.8e-57 194.7 6.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain PI_PP_I PF18363.1 OPL33763.1 - 0.00038 20.6 0.1 0.0034 17.5 0.1 2.6 2 0 0 2 2 2 1 Phosphoinositide phosphatase insertion domain LIDHydrolase PF10230.9 OPL33763.1 - 0.0088 15.6 0.0 0.02 14.5 0.0 1.6 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase C8 PF08742.11 OPL33764.1 - 3.6e-09 36.9 1.7 3.6e-09 36.9 1.7 2.6 3 0 0 3 3 3 1 C8 domain TIL PF01826.17 OPL33764.1 - 4.3e-08 33.3 29.7 2.8e-05 24.3 11.0 4.3 4 1 1 5 5 5 3 Trypsin Inhibitor like cysteine rich domain VWD PF00094.25 OPL33764.1 - 0.0029 17.9 3.0 0.01 16.1 0.6 2.7 2 0 0 2 2 2 1 von Willebrand factor type D domain Phospholip_A2_1 PF00068.19 OPL33765.1 - 4.7e-24 85.0 10.4 4.7e-24 85.0 10.4 1.5 2 0 0 2 2 2 1 Phospholipase A2 FANCI_HD2 PF14680.6 OPL33765.1 - 0.098 11.9 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 FANCI helical domain 2 Phospholip_A2_2 PF05826.12 OPL33765.1 - 8.2 6.7 14.4 34 4.7 14.4 2.0 1 1 0 1 1 1 0 Phospholipase A2 Arm_3 PF16186.5 OPL33766.1 - 1e-09 37.8 0.1 1.7e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 Atypical Arm repeat Arm PF00514.23 OPL33766.1 - 5.2e-07 29.5 7.3 0.0013 18.7 0.0 4.5 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 OPL33766.1 - 0.0099 16.4 0.0 0.033 14.7 0.0 2.0 2 0 0 2 2 2 1 HEAT-like repeat DUF4704 PF15787.5 OPL33766.1 - 0.048 12.9 0.6 0.076 12.2 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4704) VWA PF00092.28 OPL33767.1 - 4.8e-28 98.6 7.5 4.2e-16 59.7 3.4 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 OPL33767.1 - 2.8e-13 50.5 1.4 1.3e-06 29.0 0.2 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain MNSV_P7B PF06692.11 OPL33767.1 - 0.012 15.6 0.0 0.036 14.1 0.0 1.8 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein Ion_trans PF00520.31 OPL33768.1 - 4.3e-08 32.7 10.2 5.5e-08 32.3 10.2 1.1 1 0 0 1 1 1 1 Ion transport protein Peptidase_C14 PF00656.22 OPL33769.1 - 0.00053 20.0 0.1 0.0012 18.8 0.1 1.6 1 1 1 2 2 2 1 Caspase domain ResIII PF04851.15 OPL33770.1 - 2.2e-06 27.8 0.2 5.2e-06 26.6 0.1 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit WAK PF08488.11 OPL33770.1 - 0.055 14.0 0.3 0.1 13.1 0.0 1.6 2 0 0 2 2 2 0 Wall-associated kinase RIG-I_C-RD PF11648.8 OPL33771.1 - 0.0046 17.2 0.3 0.011 16.0 0.3 1.6 1 0 0 1 1 1 1 C-terminal domain of RIG-I Herpes_glycoH_C PF17488.2 OPL33771.1 - 0.018 14.9 0.2 0.024 14.4 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein H C-terminal domain Arc_trans_TRASH PF08394.10 OPL33771.1 - 0.026 14.9 0.1 0.045 14.1 0.1 1.5 1 0 0 1 1 1 0 Archaeal TRASH domain DOMON PF03351.17 OPL33772.1 - 5.3e-12 46.0 1.3 2e-10 40.9 0.4 2.0 1 1 1 2 2 2 2 DOMON domain DUF3188 PF11384.8 OPL33773.1 - 0.034 13.9 0.3 0.051 13.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) Gram_pos_anchor PF00746.21 OPL33773.1 - 0.22 11.5 0.8 0.36 10.8 0.8 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif PLA2_B PF01735.18 OPL33774.1 - 9.2e-18 63.9 0.0 1.2e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Lysophospholipase catalytic domain PLA2_B PF01735.18 OPL33775.1 - 9e-11 40.8 0.1 1.1e-10 40.5 0.1 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain ISK_Channel PF02060.15 OPL33775.1 - 0.0019 17.9 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Slow voltage-gated potassium channel DNase_II PF03265.15 OPL33776.1 - 3e-06 26.8 0.0 6.3e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 Deoxyribonuclease II Peptidase_C2 PF00648.21 OPL33777.1 - 1e-78 264.4 0.0 2.4e-76 256.6 0.0 2.0 1 1 1 2 2 2 2 Calpain family cysteine protease Calpain_III PF01067.22 OPL33777.1 - 3.3e-08 33.9 0.0 7.5e-08 32.7 0.0 1.6 2 0 0 2 2 2 1 Calpain large subunit, domain III Pox_A28 PF04584.14 OPL33778.1 - 0.0062 16.7 0.8 0.0074 16.5 0.8 1.1 1 0 0 1 1 1 1 Poxvirus A28 family Pilin_N PF07790.11 OPL33778.1 - 0.032 15.2 0.2 0.033 15.1 0.2 1.2 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal SUR7 PF06687.12 OPL33778.1 - 0.071 12.7 0.5 0.069 12.8 0.5 1.1 1 0 0 1 1 1 0 SUR7/PalI family DUF3819 PF12842.7 OPL33779.1 - 0.0099 15.8 1.7 0.016 15.2 1.7 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3819) DUF3145 PF11343.8 OPL33779.1 - 0.035 13.7 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3145) Spike_torovirin PF17072.5 OPL33779.1 - 0.085 10.0 0.0 0.094 9.8 0.0 1.0 1 0 0 1 1 1 0 Torovirinae spike glycoprotein DASH_Ask1 PF08655.10 OPL33779.1 - 0.11 12.4 0.1 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 DASH complex subunit Ask1 Anthrax_toxA PF03497.16 OPL33780.1 - 0.022 14.9 0.1 0.032 14.4 0.1 1.2 1 0 0 1 1 1 0 Anthrax toxin LF subunit ParG PF09274.10 OPL33780.1 - 0.023 14.8 0.1 0.048 13.8 0.1 1.5 1 0 0 1 1 1 0 ParG Destabilase PF05497.12 OPL33781.1 - 1.2e-28 99.8 15.1 1.9e-28 99.2 15.1 1.3 1 0 0 1 1 1 1 Destabilase Syndecan PF01034.20 OPL33782.1 - 0.00059 19.7 3.4 0.00091 19.1 3.4 1.2 1 0 0 1 1 1 1 Syndecan domain Protocadherin PF08374.11 OPL33782.1 - 0.0027 17.7 0.0 0.0033 17.4 0.0 1.1 1 0 0 1 1 1 1 Protocadherin SKG6 PF08693.10 OPL33782.1 - 0.0039 16.6 4.5 0.0063 15.9 4.5 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.12 OPL33782.1 - 0.013 15.3 1.8 0.023 14.5 1.7 1.4 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Amnionless PF14828.6 OPL33782.1 - 0.1 11.4 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Amnionless TMEM210 PF15195.6 OPL33782.1 - 0.1 13.0 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 TMEM210 family RIFIN PF02009.16 OPL33782.1 - 0.54 10.1 2.9 0.72 9.7 2.9 1.1 1 0 0 1 1 1 0 Rifin RcsD_ABL PF16359.5 OPL33783.1 - 0.081 13.1 0.2 14 5.8 0.0 2.4 2 1 0 2 2 2 0 RcsD-ABL domain DDE_Tnp_IS240 PF13610.6 OPL33783.1 - 0.099 12.9 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 DDE domain DUF4975 PF16346.5 OPL33784.1 - 0.0054 16.8 0.5 0.013 15.6 0.5 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4975) DUF3244 PF11589.8 OPL33784.1 - 0.016 15.3 2.9 1.9 8.6 0.5 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF3244) PPC PF04151.15 OPL33784.1 - 2.2 9.4 7.2 1.2 10.3 3.9 2.0 1 1 1 2 2 2 0 Bacterial pre-peptidase C-terminal domain VWA_2 PF13519.6 OPL33785.1 - 5.3e-07 30.3 0.0 6.1e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 OPL33785.1 - 0.0015 18.8 0.0 0.0019 18.5 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain CobT_C PF11775.8 OPL33785.1 - 0.0056 16.3 0.0 0.0062 16.2 0.0 1.1 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT VWA domain Glyco_hydro_59 PF02057.15 OPL33786.1 - 0.027 13.7 0.0 0.053 12.8 0.0 1.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 59 Methyltransf_11 PF08241.12 OPL33786.1 - 0.077 13.7 0.0 0.29 11.8 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 OPL33786.1 - 0.097 13.4 0.0 1.2 9.9 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase domain Ninjurin PF04923.12 OPL33787.1 - 0.069 13.1 2.0 2.1 8.3 0.0 2.7 2 0 0 2 2 2 0 Ninjurin EphA2_TM PF14575.6 OPL33787.1 - 0.81 10.6 4.5 12 6.9 1.1 2.8 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Peptidase_M56 PF05569.11 OPL33787.1 - 1.4 8.1 4.8 1.4 8.0 0.1 2.5 3 0 0 3 3 3 0 BlaR1 peptidase M56 Cadherin PF00028.17 OPL33788.1 - 1.7e-14 54.0 0.8 0.00039 20.8 0.2 3.2 3 0 0 3 3 3 3 Cadherin domain Big_9 PF17963.1 OPL33788.1 - 0.00064 20.4 19.3 0.16 12.8 1.8 3.8 3 1 0 3 3 3 2 Bacterial Ig domain Cadherin_3 PF16184.5 OPL33788.1 - 0.0034 17.4 2.6 8.2 6.5 0.1 3.6 2 1 1 3 3 3 2 Cadherin-like Cadherin_4 PF17803.1 OPL33788.1 - 0.012 16.3 17.6 0.67 10.6 3.7 4.2 3 2 0 3 3 3 0 Bacterial cadherin-like domain E1_DerP2_DerF2 PF02221.15 OPL33789.1 - 2.9e-21 76.3 0.3 3.4e-21 76.1 0.3 1.0 1 0 0 1 1 1 1 ML domain Dak1 PF02733.17 OPL33790.1 - 3e-118 394.2 3.2 4e-118 393.8 3.2 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 OPL33790.1 - 1.2e-39 136.0 0.7 4.1e-39 134.3 0.3 1.9 2 0 0 2 2 2 1 DAK2 domain SRCR PF00530.18 OPL33791.1 - 7.7e-20 71.3 3.7 4.2e-11 43.2 0.7 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 OPL33791.1 - 0.0016 19.0 0.2 0.003 18.1 0.2 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 OPL33791.1 - 0.032 14.7 0.1 0.055 14.0 0.1 1.4 1 0 0 1 1 1 0 Hepsin, SRCR domain SRCR PF00530.18 OPL33792.1 - 2.5e-19 69.6 3.6 1.2e-10 41.8 0.3 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 OPL33792.1 - 0.00034 21.1 0.3 0.00067 20.2 0.3 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 OPL33792.1 - 0.016 15.7 0.1 0.026 15.0 0.1 1.4 1 0 0 1 1 1 0 Hepsin, SRCR domain SRCR PF00530.18 OPL33793.1 - 1.6e-19 70.2 3.9 6.5e-11 42.6 0.6 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 OPL33793.1 - 0.00064 20.2 0.9 0.0013 19.2 0.9 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 OPL33793.1 - 0.015 15.8 0.2 0.025 15.1 0.2 1.4 1 0 0 1 1 1 0 Hepsin, SRCR domain Roc PF08477.13 OPL33794.1 - 9.2e-08 32.3 0.7 2.8e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 OPL33794.1 - 1.5e-05 24.9 0.7 0.00037 20.4 0.0 3.1 3 1 1 4 4 4 1 C-terminal of Roc, COR, domain Ras PF00071.22 OPL33794.1 - 0.053 13.1 0.5 0.26 10.9 0.3 2.1 1 1 0 1 1 1 0 Ras family AAA_22 PF13401.6 OPL33795.1 - 0.0007 19.9 0.0 0.0023 18.2 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 OPL33795.1 - 0.0015 18.8 0.0 0.0046 17.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 OPL33795.1 - 0.0019 17.7 0.5 0.0067 15.9 0.1 2.0 2 0 0 2 2 2 1 PhoH-like protein AAA_30 PF13604.6 OPL33795.1 - 0.0029 17.3 0.0 0.0058 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Peptidase_S41 PF03572.18 OPL33795.1 - 0.008 15.8 0.2 0.075 12.6 0.0 2.2 2 0 0 2 2 2 1 Peptidase family S41 CbiA PF01656.23 OPL33795.1 - 0.012 15.6 0.9 0.082 13.0 0.0 2.4 2 1 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain DEAD PF00270.29 OPL33795.1 - 0.017 14.9 2.8 2.3 7.9 0.0 2.3 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_28 PF13521.6 OPL33795.1 - 0.021 15.1 0.1 0.093 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 OPL33795.1 - 0.036 14.4 0.0 0.087 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 OPL33795.1 - 0.041 13.9 0.0 0.29 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TrwB_AAD_bind PF10412.9 OPL33795.1 - 0.043 12.7 0.1 1.2 7.9 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RecG_N PF17190.4 OPL33795.1 - 0.048 14.4 2.8 0.66 10.7 0.1 2.6 2 0 0 2 2 2 0 RecG N-terminal helical domain AAA_33 PF13671.6 OPL33795.1 - 0.049 13.8 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 OPL33795.1 - 0.057 13.4 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 OPL33795.1 - 0.07 13.7 0.6 0.37 11.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain PRANC PF09372.10 OPL33795.1 - 0.085 13.2 1.9 0.23 11.8 1.7 1.9 1 1 0 1 1 1 0 PRANC domain Mg_chelatase PF01078.21 OPL33795.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 OPL33795.1 - 0.15 11.7 0.0 0.15 11.7 0.0 2.5 2 1 0 3 3 3 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 OPL33795.1 - 0.19 11.6 3.1 3.9 7.3 0.0 3.1 3 0 0 3 3 3 0 NTPase Phage_Mu_Gp45 PF06890.12 OPL33795.1 - 0.21 11.3 1.8 8 6.3 0.1 2.4 2 1 0 2 2 2 0 Bacteriophage Mu Gp45 protein Spc29 PF17082.5 OPL33795.1 - 0.25 11.2 4.0 0.097 12.5 0.8 1.9 2 1 0 2 2 2 0 Spindle Pole Component 29 EF-G-binding_N PF07299.11 OPL33795.1 - 2.1 8.9 5.9 3 8.4 0.9 2.6 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal AAA_24 PF13479.6 OPL33795.1 - 7.7 6.2 8.2 2.6 7.7 0.1 2.7 1 1 1 2 2 2 0 AAA domain TMEM173 PF15009.6 OPL33796.1 - 1.3e-16 60.6 0.4 2.4e-16 59.8 0.4 1.3 1 1 0 1 1 1 1 Transmembrane protein 173 TMEM173 PF15009.6 OPL33797.1 - 5.4e-14 52.0 1.7 1e-11 44.6 1.7 2.2 1 1 0 1 1 1 1 Transmembrane protein 173 TIR_2 PF13676.6 OPL33797.1 - 0.049 14.2 0.1 0.11 13.1 0.1 1.6 1 0 0 1 1 1 0 TIR domain Death PF00531.22 OPL33799.1 - 1.1e-14 54.4 4.0 2.9e-07 30.6 0.0 2.6 2 0 0 2 2 2 2 Death domain COR PF16095.5 OPL33799.1 - 1.6e-09 37.9 1.9 3.8e-09 36.6 1.9 1.6 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 OPL33799.1 - 2.3e-07 31.0 0.0 1.1e-06 28.9 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL33799.1 - 0.0038 16.8 0.0 0.34 10.5 0.0 2.8 1 1 0 1 1 1 1 Ras family COR PF16095.5 OPL33800.1 - 9.8e-21 74.4 2.5 1.1e-20 74.2 0.6 2.0 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain ig PF00047.25 OPL33800.1 - 5.1e-09 36.2 0.2 3.1e-08 33.7 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 OPL33800.1 - 1.1e-06 29.1 0.2 2.8e-06 27.8 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL33800.1 - 9e-06 25.7 0.0 2.5e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 OPL33800.1 - 0.00074 19.7 2.4 0.0013 18.8 0.6 2.5 2 1 0 2 2 2 1 Immunoglobulin V-set domain Amidase PF01425.21 OPL33800.1 - 0.028 13.4 0.0 0.044 12.7 0.0 1.2 1 0 0 1 1 1 0 Amidase Fasciclin PF02469.22 OPL33800.1 - 0.1 12.8 0.0 3 8.1 0.0 2.4 2 0 0 2 2 2 0 Fasciclin domain Ig_2 PF13895.6 OPL33800.1 - 0.19 12.1 0.7 0.43 10.9 0.2 1.9 2 0 0 2 2 2 0 Immunoglobulin domain Roc PF08477.13 OPL33801.1 - 3.2e-09 37.0 0.2 8.2e-09 35.7 0.2 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 OPL33801.1 - 9.7e-06 25.3 0.3 2.3e-05 24.1 0.1 1.7 2 0 0 2 2 2 1 Ras family Arf PF00025.21 OPL33801.1 - 0.0012 18.3 1.5 0.0013 18.2 0.5 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_14 PF13173.6 OPL33801.1 - 0.0015 18.6 0.4 0.0032 17.5 0.2 1.7 1 1 1 2 2 2 1 AAA domain ATPase_2 PF01637.18 OPL33801.1 - 0.0033 17.4 0.3 0.0039 17.1 0.3 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 OPL33801.1 - 0.011 15.9 0.7 0.016 15.3 0.4 1.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.6 OPL33801.1 - 0.014 15.9 0.0 0.021 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4446 PF14584.6 OPL33801.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Dynamin_N PF00350.23 OPL33801.1 - 0.02 14.9 0.4 0.031 14.3 0.4 1.3 1 0 0 1 1 1 0 Dynamin family PduV-EutP PF10662.9 OPL33801.1 - 0.026 14.3 0.1 0.047 13.4 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 OPL33801.1 - 0.068 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_35 PF14516.6 OPL33801.1 - 0.092 11.6 0.1 0.14 11.0 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain DUF4168 PF13767.6 OPL33802.1 - 0.064 14.4 0.4 0.35 12.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4168) DUF1180 PF06679.12 OPL33803.1 - 6.2e-05 23.5 4.0 9.5e-05 22.9 4.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) SID-1_RNA_chan PF13965.6 OPL33803.1 - 0.00094 17.7 2.6 0.00094 17.7 1.6 1.4 1 1 0 1 1 1 1 dsRNA-gated channel SID-1 Podoplanin PF05808.11 OPL33803.1 - 0.0013 18.9 7.0 0.0025 17.9 7.0 1.4 1 0 0 1 1 1 1 Podoplanin DUF4448 PF14610.6 OPL33803.1 - 0.0028 17.5 0.1 0.0047 16.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Orf78 PF06024.12 OPL33803.1 - 0.0041 17.4 0.2 0.01 16.1 0.1 1.7 2 0 0 2 2 2 1 Orf78 (ac78) Mucin PF01456.17 OPL33803.1 - 0.0045 17.0 17.6 0.0085 16.1 17.6 1.6 1 0 0 1 1 1 1 Mucin-like glycoprotein RIFIN PF02009.16 OPL33803.1 - 0.0068 16.3 0.1 0.013 15.4 0.1 1.4 1 0 0 1 1 1 1 Rifin EphA2_TM PF14575.6 OPL33803.1 - 0.0096 16.8 0.0 0.02 15.7 0.0 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 OPL33803.1 - 0.078 12.9 19.0 1.9 8.4 19.0 2.2 1 1 0 1 1 1 0 TMEM154 protein family ECSCR PF15820.5 OPL33803.1 - 0.079 12.8 1.8 0.12 12.2 1.0 1.7 1 1 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator NB PF04159.13 OPL33803.1 - 0.097 12.7 0.2 0.097 12.7 0.2 1.8 2 0 0 2 2 2 0 NB glycoprotein Kei1 PF08552.11 OPL33803.1 - 0.14 12.0 0.6 0.2 11.5 0.6 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4330 PF14221.6 OPL33803.1 - 1.3 9.3 4.8 0.42 10.8 0.3 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4330) MAP17 PF15807.5 OPL33803.1 - 8.9 6.6 6.1 4.2 7.6 3.5 1.8 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 bZIP_2 PF07716.15 OPL33804.1 - 2.9e-06 27.2 12.0 6.4e-06 26.2 12.0 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 OPL33804.1 - 3e-05 24.4 10.6 4.3e-05 23.9 8.6 1.9 2 0 0 2 2 2 1 bZIP Maf transcription factor bZIP_1 PF00170.21 OPL33804.1 - 3.5e-05 23.8 8.9 8.2e-05 22.6 8.9 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 OPL33805.1 - 4.3e-06 26.7 7.0 4.3e-06 26.7 7.0 3.6 4 1 0 4 4 4 2 Basic region leucine zipper bZIP_1 PF00170.21 OPL33805.1 - 6.3e-05 23.0 15.4 6.3e-05 23.0 15.4 2.3 3 0 0 3 3 3 1 bZIP transcription factor bZIP_Maf PF03131.17 OPL33805.1 - 0.0021 18.5 13.2 0.0028 18.1 12.3 1.7 1 1 0 1 1 1 1 bZIP Maf transcription factor ALMT PF11744.8 OPL33805.1 - 2.3 7.0 6.3 2.5 6.8 6.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Lectin_C PF00059.21 OPL33807.1 - 3.3e-18 66.4 6.8 7e-18 65.3 6.8 1.6 1 0 0 1 1 1 1 Lectin C-type domain Chordopox_A33R PF05966.12 OPL33807.1 - 0.00096 18.5 4.1 0.002 17.4 4.1 1.5 1 0 0 1 1 1 1 Chordopoxvirus A33R protein RecO_N_2 PF13114.6 OPL33807.1 - 0.025 14.3 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 RecO N terminal UL45 PF05473.12 OPL33807.1 - 0.055 13.1 0.2 0.095 12.3 0.2 1.4 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like SAA PF00277.18 OPL33808.1 - 4.5e-11 43.1 4.5 1.1e-08 35.5 0.4 2.5 2 1 1 3 3 3 2 Serum amyloid A protein DASH_Duo1 PF08651.10 OPL33808.1 - 0.0024 17.6 0.9 0.009 15.8 0.9 1.9 1 1 0 1 1 1 1 DASH complex subunit Duo1 YtxH PF12732.7 OPL33808.1 - 0.059 13.9 8.5 5.2 7.7 8.5 2.2 1 1 0 1 1 1 0 YtxH-like protein CAF-1_p150 PF11600.8 OPL33808.1 - 0.14 11.8 8.0 0.29 10.8 8.0 1.5 1 1 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF1690 PF07956.11 OPL33808.1 - 0.41 11.1 7.0 0.54 10.7 7.0 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) HAUS6_N PF14661.6 OPL33808.1 - 0.56 9.7 4.0 0.67 9.5 4.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus SR-25 PF10500.9 OPL33808.1 - 2.4 7.7 16.9 2.2 7.8 16.0 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Antimicrobial12 PF08107.11 OPL33808.1 - 2.6 7.9 3.8 3.7 7.4 3.8 1.2 1 0 0 1 1 1 0 Pleurocidin family Toxin_38 PF14866.6 OPL33808.1 - 5.7 7.3 5.4 1.7 9.0 1.2 2.1 2 1 1 3 3 3 0 Potassium channel toxin RRM_1 PF00076.22 OPL33809.1 - 1.1e-28 98.9 0.6 7.9e-20 70.5 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 OPL33809.1 - 0.0039 17.2 0.0 0.33 11.0 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Cauli_AT PF03233.13 OPL33809.1 - 0.039 13.9 0.6 0.039 13.9 0.6 2.4 3 0 0 3 3 3 0 Aphid transmission protein Imm30 PF15565.6 OPL33809.1 - 0.06 13.4 0.3 0.23 11.6 0.3 2.0 1 0 0 1 1 1 0 Immunity protein 30 Roc PF08477.13 OPL33810.1 - 1.3e-05 25.4 0.1 0.0017 18.6 0.0 3.0 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 OPL33810.1 - 0.038 13.7 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 OPL33810.1 - 0.1 12.7 0.0 0.39 10.8 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase ABC_tran PF00005.27 OPL33810.1 - 0.11 13.1 2.9 0.91 10.0 1.8 2.5 2 1 0 2 2 2 0 ABC transporter DUF4175 PF13779.6 OPL33810.1 - 2.3 6.0 8.3 3.2 5.6 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RIG-I_C PF18119.1 OPL33811.1 - 7.2e-07 29.3 0.7 2.1e-06 27.8 0.1 2.1 2 0 0 2 2 2 1 RIG-I receptor C-terminal domain ResIII PF04851.15 OPL33811.1 - 0.0012 18.9 1.6 0.0033 17.5 0.8 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 OPL33811.1 - 0.016 15.0 1.8 0.038 13.8 1.3 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase Ig_3 PF13927.6 OPL33812.1 - 4.9e-25 87.9 4.1 0.00014 22.4 0.0 5.7 6 0 0 6 6 6 5 Immunoglobulin domain ig PF00047.25 OPL33812.1 - 1.3e-14 54.1 7.1 0.032 14.4 0.1 6.3 4 2 1 5 5 5 5 Immunoglobulin domain I-set PF07679.16 OPL33812.1 - 9e-13 48.1 0.7 0.0033 17.5 0.0 5.3 5 1 0 5 5 5 3 Immunoglobulin I-set domain Ig_2 PF13895.6 OPL33812.1 - 4.5e-12 46.1 7.9 0.047 14.0 0.0 6.1 3 2 1 5 5 5 5 Immunoglobulin domain C2-set_2 PF08205.12 OPL33812.1 - 2.6e-11 43.5 0.4 1.2e-05 25.3 0.1 3.3 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 OPL33812.1 - 6.1e-08 32.8 2.8 0.017 15.3 0.0 4.2 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL33812.1 - 0.0045 16.5 1.6 0.47 10.1 0.3 2.9 2 0 0 2 2 2 1 Immunoglobulin domain C1-set PF07654.15 OPL33812.1 - 0.018 15.4 0.0 0.14 12.6 0.0 2.6 1 0 0 1 1 1 0 Immunoglobulin C1-set domain O-antigen_lig PF13425.6 OPL33812.1 - 0.066 12.0 1.0 0.1 11.4 1.0 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TRAP_alpha PF03896.16 OPL33812.1 - 0.076 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PAN_1 PF00024.26 OPL33813.1 - 2.3e-05 24.3 0.2 2.4e-05 24.2 0.2 1.2 1 0 0 1 1 1 1 PAN domain Guanylate_cyc PF00211.20 OPL33813.1 - 0.11 12.1 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain DUF778 PF05608.12 OPL33814.1 - 0.017 15.5 0.4 0.03 14.7 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF778) Efg1 PF10153.9 OPL33814.1 - 0.091 13.1 0.6 0.16 12.3 0.6 1.4 1 0 0 1 1 1 0 rRNA-processing protein Efg1 DUF5421 PF17458.2 OPL33815.1 - 0.0013 18.2 0.7 1.2 8.5 0.0 2.5 3 0 0 3 3 3 2 Family of unknown function (DUF5421) DUF1722 PF08349.11 OPL33815.1 - 0.063 13.6 0.0 1.8 8.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1722) Dicty_spore_N PF04562.12 OPL33815.1 - 6.9 7.4 21.3 0.44 11.3 11.9 2.1 1 1 1 2 2 2 0 Dictyostelium spore coat protein, N terminus Fibrinogen_C PF00147.18 OPL33817.1 - 2.1e-56 191.2 3.4 2.5e-56 190.9 3.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 OPL33817.1 - 0.016 14.5 0.1 0.022 14.0 0.1 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain Lipase_GDSL PF00657.22 OPL33821.1 - 1.8e-06 28.0 0.4 4.2e-06 26.9 0.1 1.7 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 OPL33821.1 - 0.00047 20.6 1.8 0.0061 17.0 1.5 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Syndecan PF01034.20 OPL33821.1 - 0.029 14.3 0.1 0.097 12.6 0.1 1.9 1 0 0 1 1 1 0 Syndecan domain Glycophorin_A PF01102.18 OPL33821.1 - 0.057 13.7 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Glycophorin A TMEM51 PF15345.6 OPL33821.1 - 0.057 13.2 0.1 0.098 12.5 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 CD34_antigen PF06365.12 OPL33821.1 - 0.082 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family Y_phosphatase PF00102.27 OPL33822.1 - 8.4e-89 297.2 8.1 1.6e-44 152.2 0.1 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 OPL33822.1 - 1.5e-09 37.8 0.5 0.00081 19.2 0.2 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 OPL33822.1 - 7.8e-06 26.1 0.2 5.1e-05 23.5 0.1 2.4 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 OPL33822.1 - 0.0005 20.1 0.3 0.0014 18.7 0.2 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family Methyltransf_PK PF05891.12 OPL33822.1 - 0.037 13.5 0.6 0.085 12.4 0.0 1.9 2 0 0 2 2 2 0 AdoMet dependent proline di-methyltransferase Torsin PF06309.11 OPL33825.1 - 5.8e-36 123.4 2.8 6e-36 123.3 1.2 1.8 2 0 0 2 2 2 1 Torsin AAA PF00004.29 OPL33825.1 - 1.6e-08 35.0 0.0 3e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 OPL33825.1 - 5.2e-07 30.0 0.5 5.6e-05 23.4 0.5 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 OPL33825.1 - 0.00011 22.3 0.0 0.00024 21.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 OPL33825.1 - 0.00011 21.7 0.1 0.00029 20.4 0.1 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_19 PF13245.6 OPL33825.1 - 0.0011 19.3 0.3 0.0075 16.6 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.6 OPL33825.1 - 0.0015 18.5 0.0 0.0033 17.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 OPL33825.1 - 0.016 14.5 0.3 0.054 12.7 0.3 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_2 PF07724.14 OPL33825.1 - 0.019 15.1 0.0 0.034 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 OPL33825.1 - 0.023 15.1 0.1 0.96 9.8 0.0 2.1 1 1 1 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 OPL33825.1 - 0.025 15.0 0.0 0.073 13.5 0.0 1.9 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 OPL33825.1 - 0.032 13.4 0.0 0.053 12.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_28 PF13521.6 OPL33825.1 - 0.061 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain STALD PF18185.1 OPL33825.1 - 0.078 12.3 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Sir2- and TIR-associating SLOG family Viral_helicase1 PF01443.18 OPL33825.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF2785 PF10978.8 OPL33825.1 - 0.11 12.3 0.0 0.29 10.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2785) AAA_30 PF13604.6 OPL33825.1 - 0.24 11.1 0.0 0.4 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain V-set PF07686.17 OPL33827.1 - 8.1e-12 45.3 0.1 1.7e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 OPL33827.1 - 9e-06 25.8 0.2 2e-05 24.7 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 OPL33827.1 - 3e-05 24.5 0.0 0.0001 22.8 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL33827.1 - 0.00011 22.2 0.0 0.00027 20.9 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_5 PF16681.5 OPL33827.1 - 0.0014 19.0 0.1 0.054 13.9 0.1 2.4 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Sarcoglycan_2 PF05510.13 OPL33827.1 - 0.006 15.4 0.1 0.0092 14.8 0.1 1.2 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon Otopetrin PF03189.13 OPL33827.1 - 0.021 13.7 0.0 0.044 12.6 0.0 1.7 1 1 0 1 1 1 0 Otopetrin GxGYxYP_C PF14323.6 OPL33827.1 - 0.031 14.1 0.1 0.065 13.1 0.1 1.5 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain DUF3377 PF11857.8 OPL33827.1 - 0.035 14.0 0.1 0.11 12.4 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Ig_2 PF13895.6 OPL33827.1 - 0.053 13.9 0.1 0.65 10.4 0.1 2.3 1 1 0 1 1 1 0 Immunoglobulin domain Izumo-Ig PF16706.5 OPL33827.1 - 0.058 13.5 0.1 0.18 11.9 0.0 1.8 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Sulf_transp PF04143.14 OPL33827.1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Sulphur transport TMEM154 PF15102.6 OPL33827.1 - 0.41 10.6 5.9 0.093 12.6 0.5 2.2 2 0 0 2 2 2 0 TMEM154 protein family VWD PF00094.25 OPL33828.1 - 2.4e-30 105.9 2.7 2.4e-30 105.9 2.7 2.0 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 OPL33828.1 - 1.9e-11 44.2 3.1 1.9e-11 44.2 3.1 2.3 3 0 0 3 3 3 1 C8 domain TA_inhibitor PF17574.2 OPL33828.1 - 0.63 10.1 4.4 1.9 8.6 0.3 2.7 2 1 0 2 2 2 0 Inhibitor of toxin/antitoxin system (Gp4.5) WSC PF01822.19 OPL33829.1 - 4.6e-30 103.6 34.0 2.4e-23 82.1 7.6 3.1 3 0 0 3 3 3 2 WSC domain SAP PF02037.27 OPL33829.1 - 0.018 14.8 0.1 1.2 8.9 0.0 3.2 3 0 0 3 3 3 0 SAP domain ComC PF03047.14 OPL33829.1 - 0.17 11.7 1.2 11 6.0 0.1 2.3 2 0 0 2 2 2 0 COMC family EGF_3 PF12947.7 OPL33829.1 - 9.3 6.5 22.0 0.13 12.5 9.9 3.8 2 2 0 2 2 2 0 EGF domain WSC PF01822.19 OPL33830.1 - 2e-08 34.3 0.3 2e-08 34.3 0.3 2.5 2 1 0 2 2 2 1 WSC domain EGF_Tenascin PF18720.1 OPL33830.1 - 0.0059 16.6 1.2 0.013 15.5 1.2 1.6 1 0 0 1 1 1 1 Tenascin EGF domain EGF_3 PF12947.7 OPL33830.1 - 0.21 11.8 15.8 0.29 11.4 10.6 3.1 2 1 0 2 2 2 0 EGF domain EGF_Tenascin PF18720.1 OPL33831.1 - 2.4e-06 27.4 8.6 0.0066 16.5 1.0 2.2 2 0 0 2 2 2 2 Tenascin EGF domain EGF_3 PF12947.7 OPL33831.1 - 0.00024 21.2 29.6 0.12 12.5 9.8 4.2 1 1 2 3 3 3 2 EGF domain EB PF01683.18 OPL33831.1 - 0.43 10.9 25.7 3.2 8.1 8.6 2.3 1 1 1 2 2 2 0 EB module EGF_2 PF07974.13 OPL33831.1 - 0.46 10.9 25.3 2.2 8.7 8.8 2.6 2 0 0 2 2 2 0 EGF-like domain A_deamin PF02137.18 OPL33832.1 - 2e-42 145.8 0.0 2.5e-42 145.5 0.0 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain HEPN PF05168.14 OPL33833.1 - 2.4e-11 43.8 0.3 1.6e-09 37.9 0.0 3.7 4 0 0 4 4 4 1 HEPN domain HATPase_c_3 PF13589.6 OPL33833.1 - 0.0011 18.8 0.0 0.0031 17.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DnaJ PF00226.31 OPL33833.1 - 0.014 15.5 0.0 0.061 13.5 0.0 2.1 1 0 0 1 1 1 0 DnaJ domain DUF4942 PF13708.6 OPL33833.1 - 0.028 14.4 2.7 0.046 13.7 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4942) Cornifin PF02389.15 OPL33835.1 - 3.8e-16 59.5 17.0 0.014 15.6 0.0 7.1 4 1 3 7 7 7 5 Cornifin (SPRR) family EZH2_N PF18601.1 OPL33835.1 - 3.4 8.0 5.0 6.8 7.1 5.0 1.4 1 0 0 1 1 1 0 EZH2 N-terminal domain CUB PF00431.20 OPL33837.1 - 2.8e-29 101.6 0.1 3.3e-29 101.4 0.1 1.1 1 0 0 1 1 1 1 CUB domain CUB PF00431.20 OPL33838.1 - 5.8e-16 58.8 0.0 6.5e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 CUB domain BIR PF00653.21 OPL33839.1 - 1.8e-30 105.4 3.5 2.4e-15 56.9 3.6 2.8 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain DNase_II PF03265.15 OPL33841.1 - 0.00068 19.0 0.0 0.00078 18.8 0.0 1.1 1 0 0 1 1 1 1 Deoxyribonuclease II Zip PF02535.22 OPL33842.1 - 0.00068 19.0 0.0 0.00082 18.7 0.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Dicty_REP PF05086.12 OPL33842.1 - 0.21 9.5 4.5 0.21 9.5 4.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 OPL33842.1 - 1.2 7.1 12.7 1.4 7.0 12.7 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PRR18 PF15671.5 OPL33842.1 - 1.5 8.6 13.8 2 8.3 13.8 1.1 1 0 0 1 1 1 0 Proline-rich protein family 18 SOG2 PF10428.9 OPL33842.1 - 2.6 7.1 15.5 3.4 6.8 15.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF1067 PF06362.11 OPL33843.1 - 0.071 13.9 0.2 0.21 12.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1067) HEPN_DZIP3 PF18738.1 OPL33844.1 - 3.4e-22 78.7 0.1 7.7e-22 77.6 0.1 1.6 1 0 0 1 1 1 1 DZIP3/ hRUL138-like HEPN AAA_22 PF13401.6 OPL33844.1 - 0.14 12.4 0.8 0.7 10.2 0.1 2.5 2 1 1 3 3 3 0 AAA domain DUF4441 PF14536.6 OPL33844.1 - 0.28 11.4 0.1 0.28 11.4 0.1 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4441) DERM PF14704.6 OPL33845.1 - 1.3e-34 119.8 4.4 1.5e-34 119.6 4.4 1.0 1 0 0 1 1 1 1 Dermatopontin Meleagrin PF08189.11 OPL33845.1 - 0.0028 17.3 1.7 0.003 17.2 0.1 2.0 2 0 0 2 2 2 1 Meleagrin/Cygnin family Gamma_PGA_hydro PF05908.11 OPL33845.1 - 0.22 10.9 0.0 0.29 10.5 0.0 1.1 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase Peptidase_C14 PF00656.22 OPL33846.1 - 1.4e-55 189.0 0.4 1.2e-33 117.1 0.1 2.2 2 0 0 2 2 2 2 Caspase domain TIL PF01826.17 OPL33847.1 - 5.8 7.3 21.9 16 5.9 7.5 2.4 1 1 1 2 2 2 0 Trypsin Inhibitor like cysteine rich domain F5_F8_type_C PF00754.25 OPL33848.1 - 0.063 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 F5/8 type C domain Fibrinogen_C PF00147.18 OPL33849.1 - 4.9e-70 235.8 10.9 5.9e-70 235.5 10.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 OPL33850.1 - 7.4e-57 192.7 5.3 1e-56 192.2 5.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 OPL33851.1 - 7.7e-69 231.9 8.4 9.6e-69 231.5 8.4 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain TFB6 PF17110.5 OPL33852.1 - 0.0017 18.2 0.6 0.0026 17.6 0.6 1.2 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH SHE3 PF17078.5 OPL33852.1 - 0.0021 17.8 4.9 0.0033 17.2 4.9 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 MRP-S27 PF10037.9 OPL33852.1 - 0.0021 17.0 2.1 0.0034 16.3 2.1 1.3 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 EzrA PF06160.12 OPL33852.1 - 0.0082 14.4 4.7 0.012 13.8 4.7 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA APG17 PF04108.12 OPL33852.1 - 0.013 14.7 5.9 0.018 14.2 5.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Exonuc_VII_L PF02601.15 OPL33852.1 - 0.024 14.2 0.8 0.031 13.9 0.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3813 PF12758.7 OPL33852.1 - 0.026 14.8 3.8 0.072 13.4 3.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3813) HEPN_DZIP3 PF18738.1 OPL33852.1 - 0.059 13.1 4.6 0.25 11.1 0.9 3.0 2 2 1 3 3 3 0 DZIP3/ hRUL138-like HEPN DUF1525 PF07511.11 OPL33852.1 - 0.099 12.8 1.3 0.2 11.8 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) DUF1664 PF07889.12 OPL33852.1 - 0.14 12.2 4.3 0.34 11.0 4.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) HsbA PF12296.8 OPL33852.1 - 0.21 12.0 2.5 0.61 10.5 2.5 1.7 1 0 0 1 1 1 0 Hydrophobic surface binding protein A DUF3490 PF11995.8 OPL33852.1 - 0.26 11.1 3.0 1.3 8.8 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3490) DUF5595 PF18077.1 OPL33852.1 - 0.49 10.5 4.1 15 5.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) DUF4795 PF16043.5 OPL33852.1 - 1.2 8.7 9.5 7.7 6.1 9.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) VWA PF00092.28 OPL33853.1 - 1.4e-33 116.6 8.0 4.3e-21 75.9 1.3 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 OPL33853.1 - 1.2e-20 74.2 2.0 7.7e-13 49.0 0.4 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain EGF PF00008.27 OPL33853.1 - 4.8e-12 45.9 21.1 1.2e-07 31.9 6.7 3.1 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 OPL33853.1 - 3.6e-08 33.7 26.2 1.2e-06 28.9 6.8 3.9 3 0 0 3 3 3 2 Human growth factor-like EGF VWA_CoxE PF05762.14 OPL33853.1 - 1.9e-06 27.5 1.1 0.16 11.3 0.0 3.2 1 1 2 3 3 3 2 VWA domain containing CoxE-like protein VWA_3 PF13768.6 OPL33853.1 - 0.0028 17.6 0.1 0.12 12.3 0.0 2.5 2 1 0 2 2 2 1 von Willebrand factor type A domain DUF1863 PF08937.11 OPL33853.1 - 0.0089 16.3 1.0 0.1 12.9 0.3 2.3 2 0 0 2 2 2 1 MTH538 TIR-like domain (DUF1863) EGF_CA PF07645.15 OPL33853.1 - 2.7 8.3 42.4 0.049 13.8 10.3 3.6 2 1 1 3 3 3 0 Calcium-binding EGF domain VWA PF00092.28 OPL33854.1 - 1.4e-23 84.0 1.5 1.5e-23 83.9 1.5 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 OPL33854.1 - 1.9e-13 51.0 0.1 2.7e-13 50.5 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Sec23_trunk PF04811.15 OPL33854.1 - 5e-05 23.0 0.5 0.0034 17.0 0.1 2.3 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain VWA_CoxE PF05762.14 OPL33854.1 - 0.16 11.3 0.3 0.36 10.2 0.3 1.5 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein EGF PF00008.27 OPL33855.1 - 3.3e-18 65.6 41.4 4.8e-08 33.2 8.8 4.4 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 OPL33855.1 - 4.8e-14 52.4 27.0 8.8e-08 32.5 9.5 4.5 4 2 0 4 4 4 2 Human growth factor-like EGF EGF_CA PF07645.15 OPL33855.1 - 2e-10 40.7 42.1 2.2e-05 24.5 7.9 4.1 3 1 1 4 4 4 3 Calcium-binding EGF domain cEGF PF12662.7 OPL33855.1 - 3.5e-08 33.2 37.9 0.0004 20.3 2.6 5.5 5 1 0 5 5 5 3 Complement Clr-like EGF-like FXa_inhibition PF14670.6 OPL33855.1 - 4.5e-05 23.6 40.0 0.063 13.6 13.3 4.0 1 1 3 4 4 4 3 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 OPL33855.1 - 0.0012 19.2 43.2 0.043 14.2 8.5 3.9 3 1 1 4 4 4 3 EGF-like domain Plasmod_Pvs28 PF06247.11 OPL33855.1 - 0.23 11.8 30.6 0.4 11.0 7.0 3.9 3 1 1 4 4 4 0 Pvs28 EGF domain Laminin_EGF PF00053.24 OPL33855.1 - 1.1 9.5 35.5 13 6.0 5.4 3.4 1 1 2 3 3 3 0 Laminin EGF domain EGF_3 PF12947.7 OPL33855.1 - 1.7 8.9 38.3 0.15 12.3 6.2 4.3 3 2 1 4 4 4 0 EGF domain 7tm_1 PF00001.21 OPL33856.1 - 4.9e-12 45.7 3.4 5.2e-12 45.6 3.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 OPL33856.1 - 0.0033 16.8 2.1 0.0038 16.6 2.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 OPL33856.1 - 0.012 15.4 1.5 0.015 15.0 1.5 1.2 1 0 0 1 1 1 0 Olfactory receptor DUF3404 PF11884.8 OPL33856.1 - 0.053 12.7 0.2 0.062 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) Dynamin_N PF00350.23 OPL33857.1 - 1.2e-17 64.4 0.2 2.3e-17 63.5 0.2 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 OPL33857.1 - 2.6e-08 33.9 0.1 1.4e-07 31.6 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 OPL33857.1 - 0.0024 17.8 1.5 0.055 13.4 0.2 2.5 2 1 0 2 2 2 1 RsgA GTPase Septin PF00735.18 OPL33857.1 - 0.018 14.3 2.1 0.41 9.9 2.1 2.2 1 1 0 1 1 1 0 Septin ACT_4 PF13291.6 OPL33857.1 - 0.069 13.8 0.2 0.17 12.5 0.2 1.7 1 0 0 1 1 1 0 ACT domain ABC_tran PF00005.27 OPL33857.1 - 0.16 12.5 0.3 0.43 11.1 0.2 1.5 1 1 0 1 1 1 0 ABC transporter AIG1 PF04548.16 OPL33857.1 - 0.21 10.9 2.4 1.5 8.1 0.4 2.8 3 1 0 3 3 3 0 AIG1 family Baculo_PEP_C PF04513.12 OPL33858.1 - 4e-05 23.7 0.5 5e-05 23.4 0.5 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Lectin_C PF00059.21 OPL33858.1 - 0.0038 17.9 0.1 0.022 15.5 0.0 2.0 1 1 1 2 2 2 1 Lectin C-type domain CdvA PF18822.1 OPL33858.1 - 0.012 15.4 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 0 CdvA-like coiled-coil domain DUF4618 PF15397.6 OPL33858.1 - 0.012 15.0 0.3 0.015 14.7 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Prefoldin_2 PF01920.20 OPL33858.1 - 0.025 14.5 0.3 0.18 11.8 0.2 2.1 1 1 1 2 2 2 0 Prefoldin subunit Apolipoprotein PF01442.18 OPL33858.1 - 0.028 14.3 0.1 0.035 14.0 0.1 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain YkyA PF10368.9 OPL33858.1 - 0.055 13.1 0.1 0.081 12.6 0.1 1.2 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein SF-assemblin PF06705.11 OPL33858.1 - 0.063 12.6 0.1 0.087 12.1 0.1 1.2 1 0 0 1 1 1 0 SF-assemblin/beta giardin Lectin_C PF00059.21 OPL33859.1 - 3.3e-15 56.7 5.9 3.3e-15 56.7 5.9 1.8 1 1 1 2 2 2 1 Lectin C-type domain Baculo_PEP_C PF04513.12 OPL33859.1 - 0.011 15.8 0.1 0.016 15.3 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 OPL33859.1 - 0.03 14.4 0.4 0.045 13.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 OPL33859.1 - 0.036 14.0 1.0 0.066 13.2 1.0 1.4 1 0 0 1 1 1 0 Prefoldin subunit XhlA PF10779.9 OPL33859.1 - 0.05 13.8 1.0 0.094 12.9 1.0 1.5 1 0 0 1 1 1 0 Haemolysin XhlA CdvA PF18822.1 OPL33859.1 - 0.062 13.1 0.8 0.091 12.6 0.8 1.2 1 0 0 1 1 1 0 CdvA-like coiled-coil domain FliD_C PF07195.12 OPL33859.1 - 0.15 11.5 1.5 0.2 11.1 1.5 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus DUF948 PF06103.11 OPL33859.1 - 0.15 12.3 0.0 0.22 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Lectin_N PF03954.14 OPL33859.1 - 0.27 11.0 2.4 0.48 10.2 2.4 1.4 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Death PF00531.22 OPL33860.1 - 0.036 14.2 0.0 0.061 13.5 0.0 1.4 1 0 0 1 1 1 0 Death domain TonB_N PF16031.5 OPL33862.1 - 0.0025 18.3 1.6 0.0025 18.3 1.6 1.4 2 0 0 2 2 2 1 TonB polyproline region COMM_domain PF07258.14 OPL33864.1 - 9.7e-20 70.5 0.4 9.7e-20 70.5 0.4 1.7 2 0 0 2 2 2 1 COMM domain DHquinase_I PF01487.15 OPL33864.1 - 0.035 14.3 0.0 0.059 13.6 0.0 1.4 1 0 0 1 1 1 0 Type I 3-dehydroquinase PAP_central PF04928.17 OPL33864.1 - 0.15 11.0 0.3 1.8 7.5 0.1 2.0 1 1 0 2 2 2 0 Poly(A) polymerase central domain Rad50_zn_hook PF04423.14 OPL33864.1 - 1.3 8.9 3.9 27 4.7 0.2 3.0 3 1 0 3 3 3 0 Rad50 zinc hook motif V-set PF07686.17 OPL33865.1 - 1.8e-05 24.9 0.1 2.3e-05 24.5 0.1 1.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 OPL33865.1 - 0.00024 21.4 0.0 0.00038 20.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL33865.1 - 0.0003 20.8 0.0 0.00044 20.2 0.0 1.3 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 OPL33865.1 - 0.00039 20.9 0.0 0.00054 20.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 OPL33865.1 - 0.00052 20.1 0.0 0.00074 19.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_4 PF16680.5 OPL33865.1 - 0.067 13.5 0.1 0.15 12.3 0.1 1.5 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain Ig_3 PF13927.6 OPL33866.1 - 1e-29 102.9 7.0 8.4e-10 39.1 0.1 4.2 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 OPL33866.1 - 2.7e-24 85.3 1.3 1.3e-10 41.4 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 OPL33866.1 - 2.1e-20 72.6 1.9 4e-06 26.8 0.1 5.3 3 2 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 OPL33866.1 - 1.8e-16 60.0 11.7 8.5e-06 25.9 0.0 5.8 3 2 1 4 4 4 3 Immunoglobulin domain Ig_5 PF16681.5 OPL33866.1 - 2.4e-07 31.1 0.7 0.18 12.2 0.1 3.5 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 OPL33866.1 - 9.3e-07 29.0 0.4 0.005 17.1 0.0 3.6 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 OPL33866.1 - 1.6e-06 28.2 7.3 0.087 13.0 0.0 5.5 4 3 2 6 6 6 2 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL33866.1 - 6.8e-06 25.6 0.4 0.35 10.5 0.2 4.0 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 OPL33866.1 - 1.5e-05 25.0 0.2 0.052 13.6 0.0 3.5 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Shisa PF13908.6 OPL33866.1 - 0.039 14.2 0.5 0.07 13.4 0.5 1.5 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator LRR_adjacent PF08191.11 OPL33866.1 - 0.057 13.6 0.2 2.4 8.4 0.0 2.6 2 0 0 2 2 2 0 LRR adjacent EGF PF00008.27 OPL33868.1 - 0.0062 16.8 5.5 0.021 15.1 5.5 2.0 1 1 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 OPL33868.1 - 0.01 16.2 2.9 0.046 14.1 2.9 2.1 1 1 0 1 1 1 0 EGF-like domain cEGF PF12662.7 OPL33868.1 - 0.088 12.8 4.6 0.21 11.5 4.6 1.7 1 0 0 1 1 1 0 Complement Clr-like EGF-like Anophelin PF10731.9 OPL33868.1 - 1.5 8.7 3.4 23 5.0 0.2 3.3 2 1 1 3 3 3 0 Thrombin inhibitor from mosquito CUB PF00431.20 OPL33869.1 - 0.00023 21.5 0.0 0.00032 21.0 0.0 1.2 1 0 0 1 1 1 1 CUB domain Ninjurin PF04923.12 OPL33870.1 - 0.0042 17.0 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 Ninjurin zf-C2H2 PF00096.26 OPL33871.1 - 0.00041 20.6 3.1 0.0011 19.3 2.7 1.9 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 OPL33871.1 - 0.00042 20.9 1.7 0.0011 19.6 1.7 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger Fibrinogen_C PF00147.18 OPL33872.1 - 6.4e-66 222.3 12.6 1.1e-65 221.6 12.6 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Laminin_EGF PF00053.24 OPL33872.1 - 6.1e-10 39.1 28.1 8.3e-07 29.1 11.3 4.6 3 3 1 4 4 4 2 Laminin EGF domain TSP_1 PF00090.19 OPL33872.1 - 3.4e-07 30.4 11.8 3.4e-07 30.4 11.8 4.2 4 1 1 5 5 5 1 Thrombospondin type 1 domain DUF1257 PF06868.11 OPL33873.1 - 0.0012 19.0 0.4 0.0024 18.1 0.4 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1257) DUF4800 PF16057.5 OPL33873.1 - 0.0016 17.8 0.1 0.0017 17.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) UNC45-central PF11701.8 OPL33873.1 - 0.045 13.7 0.1 0.074 13.0 0.1 1.3 1 1 0 1 1 1 0 Myosin-binding striated muscle assembly central HSP70 PF00012.20 OPL33874.1 - 2.9e-06 25.8 0.0 4.9e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 OPL33874.1 - 0.025 13.4 0.0 0.04 12.7 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein DDE_Tnp_4 PF13359.6 OPL33875.1 - 1.2e-13 51.1 0.0 1.4e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 OPL33875.1 - 0.0002 21.0 0.0 0.00023 20.8 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 OPL33875.1 - 0.0041 16.8 0.2 0.0048 16.6 0.2 1.1 1 0 0 1 1 1 1 Transposase DDE domain CENP-B_dimeris PF09026.10 OPL33876.1 - 2.2 8.7 8.1 0.39 11.1 0.8 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain LSDAT_euk PF18139.1 OPL33877.1 - 1.2e-18 67.5 0.1 2.4e-10 40.3 0.1 2.3 1 1 1 2 2 2 2 SLOG in TRPM LSDAT_prok PF18171.1 OPL33877.1 - 3.9e-10 39.3 0.0 4.8e-07 29.2 0.0 2.3 1 1 1 2 2 2 2 SLOG in TRPM, prokaryote VHS PF00790.19 OPL33877.1 - 0.00024 21.0 1.4 0.00064 19.6 0.2 2.1 2 0 0 2 2 2 1 VHS domain REGB_T4 PF10715.9 OPL33877.1 - 0.0023 18.2 0.5 0.0038 17.4 0.5 1.3 1 0 0 1 1 1 1 T4-page Endoribonuclease RegB FliD_C PF07195.12 OPL33877.1 - 0.024 14.1 2.1 0.18 11.2 0.1 2.6 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus Ion_trans PF00520.31 OPL33878.1 - 0.035 13.3 8.8 0.048 12.9 8.8 1.2 1 0 0 1 1 1 0 Ion transport protein Cadherin PF00028.17 OPL33879.1 - 2.1e-14 53.7 0.1 3.6e-12 46.6 0.0 3.1 3 1 0 3 3 3 1 Cadherin domain Flavi_glycop_C PF02832.16 OPL33879.1 - 0.0063 16.6 0.4 0.047 13.8 0.1 2.3 3 0 0 3 3 3 1 Flavivirus glycoprotein, immunoglobulin-like domain Cadherin_4 PF17803.1 OPL33879.1 - 0.043 14.4 4.7 0.15 12.7 0.3 2.5 2 1 0 2 2 2 0 Bacterial cadherin-like domain SRCR PF00530.18 OPL33880.1 - 6e-06 26.7 0.1 1.6e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain CD34_antigen PF06365.12 OPL33880.1 - 0.0023 17.6 0.0 0.0053 16.4 0.0 1.6 1 0 0 1 1 1 1 CD34/Podocalyxin family MLANA PF14991.6 OPL33880.1 - 0.0037 17.5 0.0 0.0085 16.4 0.0 1.6 1 0 0 1 1 1 1 Protein melan-A DUF2561 PF10812.8 OPL33880.1 - 0.0042 17.1 0.0 0.0067 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2561) DUF3377 PF11857.8 OPL33880.1 - 0.029 14.3 0.3 0.068 13.1 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Claudin_2 PF13903.6 OPL33880.1 - 0.038 13.8 0.1 0.07 12.9 0.1 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction EphA2_TM PF14575.6 OPL33880.1 - 0.052 14.4 0.6 0.1 13.5 0.1 2.0 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain LapA_dom PF06305.11 OPL33880.1 - 0.21 11.5 0.9 0.47 10.3 0.9 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Y_phosphatase PF00102.27 OPL33882.1 - 0.018 14.6 0.0 0.02 14.4 0.0 1.0 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase PF00102.27 OPL33883.1 - 0.0036 16.9 0.2 0.0061 16.2 0.2 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF4683 PF15735.5 OPL33884.1 - 0.069 12.8 0.0 0.084 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) Y_phosphatase PF00102.27 OPL33884.1 - 0.13 11.8 0.1 0.25 10.9 0.0 1.5 2 0 0 2 2 2 0 Protein-tyrosine phosphatase DUF325 PF03804.13 OPL33885.1 - 0.035 14.1 1.1 0.22 11.5 0.2 2.2 2 0 0 2 2 2 0 Viral proteins of unknown function Laminin_EGF PF00053.24 OPL33886.1 - 3.1e-06 27.2 85.6 0.00037 20.6 17.6 6.2 3 2 3 6 6 6 2 Laminin EGF domain EphA2_TM PF14575.6 OPL33886.1 - 0.0036 18.1 0.0 0.013 16.3 0.0 2.0 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain PspB PF06667.12 OPL33886.1 - 0.0052 16.8 0.5 0.88 9.7 0.0 2.3 2 0 0 2 2 2 2 Phage shock protein B Adeno_E3_CR2 PF02439.15 OPL33886.1 - 0.008 15.9 2.2 0.014 15.1 2.2 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 EGF_2 PF07974.13 OPL33886.1 - 0.015 15.6 11.9 0.015 15.6 11.9 8.3 8 1 0 8 8 8 0 EGF-like domain Syndecan PF01034.20 OPL33886.1 - 0.028 14.3 0.0 0.066 13.1 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain FAM176 PF14851.6 OPL33886.1 - 0.093 12.4 0.3 0.58 9.8 0.0 2.2 2 0 0 2 2 2 0 FAM176 family Laminin_EGF PF00053.24 OPL33887.1 - 1.1e-06 28.6 89.1 0.002 18.3 18.5 6.1 2 2 4 6 6 6 4 Laminin EGF domain SKG6 PF08693.10 OPL33887.1 - 0.028 13.8 0.7 0.05 13.0 0.7 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 OPL33887.1 - 0.061 13.1 1.4 0.1 12.4 1.4 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Ank_4 PF13637.6 OPL33890.1 - 1.3e-05 25.6 2.4 4 8.1 0.0 4.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) TPR_16 PF13432.6 OPL33890.1 - 0.00041 20.9 0.0 0.0029 18.2 0.0 2.3 2 1 1 3 3 3 2 Tetratricopeptide repeat Ank_5 PF13857.6 OPL33890.1 - 0.00046 20.4 0.1 2.1 8.8 0.0 4.1 4 1 0 4 4 4 2 Ankyrin repeats (many copies) TPR_1 PF00515.28 OPL33890.1 - 0.0044 16.8 1.0 11 6.0 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat Ank PF00023.30 OPL33890.1 - 0.0088 16.5 0.0 1 10.0 0.0 3.5 2 0 0 2 2 2 1 Ankyrin repeat TPR_2 PF07719.17 OPL33890.1 - 0.017 15.2 1.0 2.6 8.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 OPL33890.1 - 0.079 13.2 1.4 0.38 11.0 0.9 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 UvrD_C_2 PF13538.6 OPL33891.1 - 5.8e-07 29.2 0.0 0.0093 15.8 0.0 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 OPL33891.1 - 8.1e-07 29.5 0.0 0.00059 20.2 0.0 2.8 3 0 0 3 3 3 2 AAA domain UvrD_C PF13361.6 OPL33891.1 - 1.2e-06 28.2 0.0 0.00012 21.6 0.0 3.0 2 1 1 3 3 3 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 OPL33891.1 - 0.00011 21.8 14.7 0.00011 21.8 14.7 3.5 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 OPL33891.1 - 0.0002 21.6 0.0 0.41 10.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain Acetyltransf_19 PF18015.1 OPL33891.1 - 0.00092 19.4 2.4 1.2 9.4 0.2 2.7 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Focal_AT PF03623.13 OPL33891.1 - 0.022 14.8 0.3 1.3 9.0 0.0 2.7 2 0 0 2 2 2 0 Focal adhesion targeting region PhoH PF02562.16 OPL33891.1 - 0.061 12.8 0.0 2.8 7.3 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein AAA_12 PF13087.6 OPL33892.1 - 4.1e-36 124.5 1.3 4.1e-36 124.5 1.3 2.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 OPL33892.1 - 1.1e-22 81.1 16.9 7e-21 75.2 13.5 3.2 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 OPL33892.1 - 1.1e-05 25.8 1.8 0.00062 20.1 0.0 3.2 3 1 1 4 4 4 1 AAA domain AAA_30 PF13604.6 OPL33892.1 - 5.3e-05 23.0 0.0 0.005 16.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 OPL33892.1 - 0.00036 20.6 0.9 0.001 19.1 0.9 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_5 PF07728.14 OPL33892.1 - 0.012 15.6 1.2 0.95 9.5 0.0 3.8 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF4164 PF13747.6 OPL33892.1 - 0.027 14.7 0.6 0.11 12.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) PhoH PF02562.16 OPL33892.1 - 0.084 12.3 0.0 0.56 9.6 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 OPL33892.1 - 0.096 13.0 0.0 0.55 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 OPL33892.1 - 0.1 13.0 0.0 0.41 11.1 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 OPL33892.1 - 0.11 12.9 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 OPL33892.1 - 0.18 11.3 0.0 0.45 10.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Reprolysin PF01421.19 OPL33893.1 - 0.00014 21.9 0.6 0.00016 21.7 0.6 1.1 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 OPL33893.1 - 0.0012 19.1 0.9 0.0015 18.7 0.8 1.3 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 OPL33893.1 - 0.0025 17.5 0.7 0.0034 17.1 0.7 1.3 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 OPL33893.1 - 0.0059 16.5 0.5 0.0084 16.0 0.5 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M64 PF09471.10 OPL33893.1 - 0.028 14.0 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 IgA Peptidase M64 IL12 PF03039.14 OPL33893.1 - 0.037 13.4 0.1 0.044 13.1 0.1 1.1 1 0 0 1 1 1 0 Interleukin-12 alpha subunit Peptidase_M91 PF14891.6 OPL33893.1 - 0.14 12.5 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Effector protein ADAM_CR_2 PF17771.1 OPL33894.1 - 2.1e-13 50.6 0.8 3.1e-13 50.0 0.8 1.2 1 0 0 1 1 1 1 ADAM cysteine-rich domain TMEM154 PF15102.6 OPL33895.1 - 0.0032 17.4 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 OPL33895.1 - 0.0098 16.8 0.1 0.022 15.6 0.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain BatD PF13584.6 OPL33895.1 - 0.038 12.8 0.0 0.045 12.6 0.0 1.0 1 0 0 1 1 1 0 Oxygen tolerance DAP10 PF07213.11 OPL33895.1 - 0.048 13.6 0.1 0.1 12.6 0.1 1.5 1 0 0 1 1 1 0 DAP10 membrane protein LST1 PF05083.13 OPL33895.1 - 0.1 12.9 0.8 0.1 12.9 0.8 1.9 2 0 0 2 2 2 0 LST-1 protein Fibrinogen_C PF00147.18 OPL33897.1 - 7.1e-54 182.9 10.4 9.6e-54 182.5 10.4 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_C PF00147.18 OPL33898.1 - 1.3e-54 185.4 6.9 1.6e-54 185.0 6.9 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Y_phosphatase PF00102.27 OPL33899.1 - 6.7e-15 55.3 1.2 1.2e-14 54.4 1.2 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Ig_3 PF13927.6 OPL33899.1 - 7.3e-13 48.9 0.6 2.6e-12 47.2 0.6 2.0 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 OPL33899.1 - 7.7e-11 41.9 0.2 2.7e-10 40.1 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 OPL33899.1 - 6.8e-09 35.8 1.3 1.2e-08 35.0 0.2 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 OPL33899.1 - 7.2e-07 29.5 0.4 1.5e-06 28.4 0.4 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 OPL33899.1 - 0.00042 20.5 2.5 0.011 15.9 0.6 3.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 OPL33899.1 - 0.018 14.6 0.0 0.048 13.2 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain C1-set PF07654.15 OPL33899.1 - 0.19 12.1 2.3 0.42 11.0 0.4 2.5 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Y_phosphatase PF00102.27 OPL33901.1 - 2.3e-56 191.0 12.0 7.1e-45 153.4 1.5 3.5 3 1 0 3 3 3 3 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 OPL33901.1 - 0.0068 16.5 0.2 0.025 14.7 0.0 2.0 2 0 0 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.20 OPL33901.1 - 0.033 14.0 0.8 0.16 11.8 0.0 2.6 3 0 0 3 3 3 0 Dual specificity phosphatase, catalytic domain Laminin_G_3 PF13385.6 OPL33902.1 - 7e-05 23.0 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Ldl_recept_a PF00057.18 OPL33906.1 - 1.4e-07 31.6 20.0 1.3e-05 25.3 10.4 2.8 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A Hormone_5 PF00184.17 OPL33906.1 - 0.00059 20.6 7.2 0.001 19.9 7.2 1.4 1 1 0 1 1 1 1 Neurohypophysial hormones, C-terminal Domain Ig_3 PF13927.6 OPL33907.1 - 1.5e-13 51.2 14.7 3.1e-06 27.7 1.7 4.2 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 OPL33907.1 - 2.8e-08 34.0 15.5 2.9e-06 27.5 3.5 4.0 3 1 1 4 4 4 2 Immunoglobulin domain I-set PF07679.16 OPL33907.1 - 2.7e-06 27.3 5.3 0.12 12.4 0.4 5.5 3 2 1 4 4 4 1 Immunoglobulin I-set domain Ig_6 PF18452.1 OPL33907.1 - 8.4e-06 25.3 1.0 0.0024 17.4 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 OPL33907.1 - 8.4e-05 22.7 1.8 2.4 8.3 0.2 3.8 2 1 2 4 4 4 2 Immunoglobulin V-set domain ig PF00047.25 OPL33907.1 - 0.00015 21.9 10.5 0.081 13.1 0.7 4.6 4 1 0 4 4 4 2 Immunoglobulin domain Ig_4 PF16680.5 OPL33907.1 - 0.011 16.0 4.7 1.5 9.1 0.3 3.5 4 0 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 OPL33907.1 - 0.022 15.2 2.3 0.33 11.4 0.1 3.1 3 0 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DSL PF01414.19 OPL33907.1 - 0.023 15.0 5.3 0.51 10.7 0.1 3.3 4 0 0 4 4 4 0 Delta serrate ligand Adeno_E3_CR1 PF02440.15 OPL33907.1 - 0.23 11.2 5.3 0.67 9.8 0.3 3.1 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Ig_2 PF13895.6 OPL33908.1 - 2.6e-08 34.1 9.5 2.5e-06 27.7 0.9 3.8 2 1 1 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.6 OPL33908.1 - 5e-08 33.4 7.5 0.00054 20.5 3.2 4.1 2 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 OPL33908.1 - 1.4e-07 31.5 0.3 0.0014 18.7 0.2 3.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 OPL33908.1 - 0.011 15.9 3.5 3.5 7.9 0.2 3.7 4 0 0 4 4 4 0 Immunoglobulin domain Ig_6 PF18452.1 OPL33908.1 - 0.018 14.6 0.0 0.042 13.4 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 OPL33908.1 - 0.095 12.9 1.5 0.34 11.1 0.0 2.5 3 0 0 3 3 3 0 Immunoglobulin V-set domain DUF4199 PF13858.6 OPL33909.1 - 0.0033 17.9 1.8 0.0033 17.9 1.8 1.8 1 1 1 2 2 2 2 Protein of unknown function (DUF4199) SSF PF00474.17 OPL33910.1 - 4.7e-13 48.8 4.3 5.1e-13 48.7 4.3 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family SSF PF00474.17 OPL33911.1 - 3.6e-13 49.2 5.2 5.6e-13 48.5 5.2 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family Pox_A14 PF05767.12 OPL33911.1 - 1.4 9.1 7.6 1.5 9.0 0.1 3.7 4 0 0 4 4 4 0 Poxvirus virion envelope protein A14 DUF4064 PF13273.6 OPL33911.1 - 8.2 6.8 12.8 5 7.4 5.2 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Peptidase_C14 PF00656.22 OPL33913.1 - 1.1e-07 32.1 0.7 1.1e-05 25.6 0.2 2.1 2 0 0 2 2 2 2 Caspase domain Peptidase_C14 PF00656.22 OPL33914.1 - 9.9e-15 55.2 6.9 9.6e-05 22.5 0.0 4.3 2 2 1 3 3 3 3 Caspase domain Ldh_1_N PF00056.23 OPL33914.1 - 0.13 12.4 0.0 2.8 8.0 0.0 2.5 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain SprT-like PF10263.9 OPL33914.1 - 0.19 11.6 1.0 9.6 6.1 0.1 2.4 2 0 0 2 2 2 0 SprT-like family Peptidase_C13 PF01650.18 OPL33914.1 - 1.3 8.5 8.5 41 3.6 0.0 3.8 4 1 0 4 4 4 0 Peptidase C13 family Ank_4 PF13637.6 OPL33915.1 - 1.3e-09 38.4 0.1 2.5e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 OPL33915.1 - 8.8e-08 32.6 1.2 1.2e-07 32.2 0.6 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 OPL33915.1 - 0.0012 19.1 0.0 0.0029 18.0 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 OPL33915.1 - 0.0013 19.1 0.1 0.016 15.6 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Nup54_C PF18437.1 OPL33915.1 - 0.017 15.0 1.1 0.03 14.2 1.1 1.4 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain Ank_5 PF13857.6 OPL33915.1 - 0.05 13.9 0.1 0.094 13.1 0.1 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) GMC_oxred_N PF00732.19 OPL33919.1 - 1.5e-31 109.9 0.0 1.9e-31 109.6 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 OPL33919.1 - 0.00011 22.3 0.9 0.00021 21.4 0.4 1.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 OPL33919.1 - 0.0009 18.4 0.1 0.0012 18.0 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 OPL33919.1 - 0.0031 16.8 0.0 0.0033 16.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 OPL33919.1 - 0.0082 15.3 0.1 0.011 14.9 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 OPL33919.1 - 0.0094 14.7 0.0 0.013 14.3 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 OPL33919.1 - 0.0098 15.2 0.0 0.012 14.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 OPL33919.1 - 0.012 15.2 0.4 0.013 15.1 0.4 1.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 OPL33919.1 - 0.028 13.7 0.0 0.043 13.0 0.0 1.2 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 OPL33919.1 - 0.26 10.3 0.0 0.32 10.0 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A GMC_oxred_N PF00732.19 OPL33920.1 - 1.1e-24 87.4 0.0 1.6e-24 86.8 0.0 1.3 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 OPL33921.1 - 1.2e-05 25.9 0.0 1.5e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 OPL33922.1 - 3.6e-24 85.9 0.3 4.3e-24 85.7 0.3 1.0 1 0 0 1 1 1 1 GMC oxidoreductase NHL PF01436.21 OPL33923.1 - 0.073 13.2 0.4 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 NHL repeat MFS_1 PF07690.16 OPL33924.1 - 1.5e-13 50.4 1.0 1.9e-13 50.1 1.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 OPL33924.1 - 1.9e-05 23.8 2.1 2.5e-05 23.3 2.1 1.2 1 1 0 1 1 1 1 Sugar (and other) transporter V-set PF07686.17 OPL33925.1 - 0.056 13.6 0.2 0.13 12.5 0.1 1.7 1 1 1 2 2 2 0 Immunoglobulin V-set domain Ig_3 PF13927.6 OPL33926.1 - 0.0014 19.2 0.6 0.0056 17.2 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 OPL33926.1 - 0.03 14.6 0.5 0.1 12.9 0.1 2.1 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 OPL33926.1 - 0.043 14.0 0.7 0.1 12.8 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain TIM21 PF08294.11 OPL33926.1 - 0.12 12.3 1.9 2 8.3 0.3 2.5 2 0 0 2 2 2 0 TIM21 VWD PF00094.25 OPL33929.1 - 1.5e-10 41.5 4.7 2.3e-10 41.0 2.8 2.1 2 0 0 2 2 2 1 von Willebrand factor type D domain EGF_2 PF07974.13 OPL33930.1 - 0.00011 22.5 12.6 0.00034 20.9 12.6 1.9 1 0 0 1 1 1 1 EGF-like domain DUF3827 PF12877.7 OPL33930.1 - 0.00018 20.0 1.4 0.00025 19.6 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) hEGF PF12661.7 OPL33930.1 - 0.0036 17.9 6.2 0.013 16.1 6.2 2.1 1 0 0 1 1 1 1 Human growth factor-like EGF EGF PF00008.27 OPL33930.1 - 0.0053 17.0 8.2 0.0053 17.0 8.2 2.3 2 0 0 2 2 2 1 EGF-like domain DUF3377 PF11857.8 OPL33930.1 - 0.013 15.4 0.2 0.029 14.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) EGF_Tenascin PF18720.1 OPL33930.1 - 0.021 14.9 9.7 0.048 13.7 9.7 1.7 1 0 0 1 1 1 0 Tenascin EGF domain TMEM154 PF15102.6 OPL33930.1 - 0.023 14.6 0.1 0.046 13.6 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF2333 PF10095.9 OPL33930.1 - 0.12 11.4 0.1 0.16 10.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) Ank_2 PF12796.7 OPL33931.1 - 0.00012 22.5 0.0 0.00035 21.1 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 OPL33931.1 - 0.00059 20.3 0.1 0.032 14.8 0.0 2.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 OPL33931.1 - 0.008 16.6 0.0 0.026 15.0 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 OPL33931.1 - 0.025 15.0 0.1 0.18 12.3 0.0 2.2 2 1 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 OPL33932.1 - 3.2e-05 24.4 0.1 9.5e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 OPL33932.1 - 0.00086 19.6 0.0 0.0023 18.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 OPL33932.1 - 0.0092 16.5 0.0 0.027 15.1 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 OPL33932.1 - 0.014 15.8 0.5 0.041 14.3 0.0 2.1 3 0 0 3 3 3 0 Ankyrin repeat Y_phosphatase PF00102.27 OPL33933.1 - 2.1e-108 361.3 0.0 3e-73 246.3 0.0 3.0 3 0 0 3 3 3 2 Protein-tyrosine phosphatase Ig_3 PF13927.6 OPL33933.1 - 1.5e-25 89.6 12.9 2e-11 44.3 2.1 4.1 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 OPL33933.1 - 1.1e-23 83.0 1.8 8.9e-09 35.3 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 OPL33933.1 - 3.6e-19 68.7 14.1 3.2e-08 33.6 1.7 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 OPL33933.1 - 3.9e-19 68.8 9.9 5.6e-08 33.0 0.8 3.9 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 OPL33933.1 - 2.8e-11 43.5 7.8 0.0017 18.5 1.3 5.6 4 1 0 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.5 OPL33933.1 - 6.3e-07 29.7 2.5 0.0019 18.5 0.1 4.2 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 OPL33933.1 - 9.3e-06 25.8 0.5 0.0012 19.1 0.2 2.9 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 OPL33933.1 - 0.00033 20.6 0.2 2.9 8.0 0.0 4.2 3 1 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 OPL33933.1 - 0.0014 18.2 0.0 0.28 10.8 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin domain PTPlike_phytase PF14566.6 OPL33933.1 - 0.002 18.3 0.1 0.01 15.9 0.0 2.3 2 0 0 2 2 2 1 Inositol hexakisphosphate Receptor_2B4 PF11465.8 OPL33933.1 - 0.003 17.7 0.1 3.1 8.0 0.0 3.3 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Y_phosphatase3 PF13350.6 OPL33933.1 - 0.007 16.4 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 OPL33933.1 - 0.01 15.7 0.0 0.042 13.7 0.0 2.1 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain ECSCR PF15820.5 OPL33933.1 - 0.085 12.7 0.3 0.33 10.8 0.3 2.0 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 OPL33933.1 - 0.092 13.6 0.1 0.33 11.9 0.1 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain G6B PF15096.6 OPL33933.1 - 0.13 12.1 0.0 0.36 10.6 0.0 1.7 1 0 0 1 1 1 0 G6B family Syndecan PF01034.20 OPL33933.1 - 0.16 11.9 0.2 0.43 10.5 0.2 1.7 1 0 0 1 1 1 0 Syndecan domain WSC PF01822.19 OPL33936.1 - 0.075 13.2 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 WSC domain SIT PF15330.6 OPL33937.1 - 0.3 11.5 1.4 1.1 9.8 1.4 1.8 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.6 OPL33937.1 - 0.58 11.1 2.2 1.7 9.5 2.2 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ion_trans PF00520.31 OPL33939.1 - 0.00014 21.2 0.2 0.00018 20.8 0.2 1.3 1 0 0 1 1 1 1 Ion transport protein Pinin_SDK_memA PF04696.13 OPL33941.1 - 0.081 13.0 7.4 0.1 12.6 7.4 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region WSC PF01822.19 OPL33942.1 - 1e-08 35.2 25.9 1.1e-08 35.2 8.1 4.0 4 0 0 4 4 4 2 WSC domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Mollusca/Mytilus_galloprovincialis-ASM167691v1/GCA_001676915.1_ASM167691v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Mollusca/Mytilus_galloprovincialis-ASM167691v1/GCA_001676915.1_ASM167691v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Mollusca/Mytilus_galloprovincialis-ASM167691v1/GCA_001676915.1_ASM167691v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Mollusca/Mytilus_galloprovincialis-ASM167691v1/GCA_001676915.1_ASM167691v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 16:47:59 2019 # [ok]